<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ECV0</accession>
    <name>A0A232ECV0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01014488">
        <property type="protein sequence ID" value="OXU16216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ECV0"/>
    <dbReference type="STRING" id="543379.A0A232ECV0"/>
    <dbReference type="OrthoDB" id="7549404at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="769" mass="87905" checksum="B042469DE59AF43A" modified="2017-10-25" version="1">MANKRGNYFNYLRDPNIPVPHSTLQSREQQRVDDEDRNNVNREVDPIVENIEMNIGDIDENDTVQSNASSNDNSDNVDNISVENGEPNENLNEIFNDPEINEMYHDVIDDDVEDDNQEDQVGENNHADINAEVNVILNVDNDNEAVQVQINEEVREPIFEGVSLTKEESDLLIMSYVVRHSLSDVALEDLLELINCHLPEKLNYSKYRFLKRFPKLSELKSYYYCPDCLELLTFGNASHTRCTSCGKVFLLNSLKRNGHFFLHIPLKSQLINLFSSPLFNQLNRNHANETLSDVTSGAVYKFLKENNIISNYDISLQWNADGVQTFKSSKVSMCPIQVAVNELKYSIRNQNILLAGLWAAVEKPDLNLFMKPFVDELKDLHENGFQCLPPNSDEPVTVKVHTILAPVDSVERCALQNLHQYNGVCGCTFCLNPGEHIPVGRGYARIYSGGEGVKRTKDQHFRDAIQAEQEQNTINGVKGVSVLMLLPVFNIIRSFPPEYMHSVLLGVVKLFLSNWIDPKNCNESWYIGTKSAIIDDRLTQILPPSEVTRTPQSTANLKQWKASEYKNFLLYYSLPTLKDILPSNFYKHWSLFVYAVNIFNSDNIEERAFLKATSAIKLFVTKTEILYGKQIMKYNLHLMLHIPDAVKDFGALWAWSAFPFESYNFVLRNMLHSSQAGKTLYLNMMEKYKSRTGQRAFDENRLVLFGEGTMVTLSLIEKLSIEALIHESIKECSYTQDLKVYNSRCLKVYSQLSTITPNASELKPNQFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDN2</accession>
    <name>A0A232EDN2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006056">
        <property type="protein sequence ID" value="OXU16469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDN2"/>
    <dbReference type="STRING" id="543379.A0A232EDN2"/>
    <dbReference type="OrthoDB" id="5979489at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF21">
        <property type="entry name" value="CAPSID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="437" mass="49652" checksum="F0BD327CC83ECD41" modified="2017-10-25" version="1">MESHLTSGLWYADTPGKWGSPPNIKRTDVNANIGQCNRQYFTQNGKTVDLLGHLHCDVFNQNKFLLNGVELRLRLVKSKDAFCLMDFTDDDKFTIRIKEASLIVRRVKISPGVILAHANALTKATAKYPINRVEVKAFTMHRVILGDTLDNVILGQIPKRIIIGFVDNKAFNGNRKFNPFNFQHFNINYISLYVDGVQIPSKPLQPRFSGESQLFIDSFHTPPNIKRTDVNANIGQCNRQYFTQNGKTVDLLGHLHCDVFNQNKFLLNGVELRLRLVRSKDAFCLMDFTDDDKFTIRIKEASLIVRRVKISPGVILAHANALTKATAKYPINRVEVKAFTMHRGILGDTLDNVILGQIPKRIIIGFLDNKAFNGNRKFNPFNFQHFNINYISLYVDGVQIPSKPLQPRFSGESQLFIDSFHTLYSGTGIHFLNEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEG7</accession>
    <name>A0A232EEG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_000684</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71587"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71599"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71591"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71603"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71595"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005338">
        <property type="protein sequence ID" value="OXU16743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEG7"/>
    <dbReference type="STRING" id="543379.A0A232EEG7"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000013">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="66"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="154"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="233"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="333"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU16743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="427" mass="47438" checksum="34BB77D55809CF10" modified="2017-10-25" version="1">MTSAEQRRNYKSVVDAFARIVREEGVSTLWRGSVATMGRAAIVNVSQLATYSQAKIIIASEFDVPEGVQLHFYASMLSGVITAFNSMPFDITKTRIQNRKNTDGKLPGMLGVMFDIARTEGFRALWKGFWPTYCRIGPHTVITFMFNEQFARLYRLMAATLFVQPLDLIKNRMQLSGKKTSTVSVISSIMKNEGLLAMYSGLSAGLMRQATYTTTRLGIYTWLFETVSKDGPPNFITKAGLGMLAGCVGAFVGTPAEVALIRMTADGRLPLAERRNYKNVFDALFRITREEGLFTLWRGAIPTMGRAMVVNAAQLASYSQAKQALLDTGYFEENITLHFASSMISGLVTTAASMPVDIAKTRIQNMKTINGKPEFTGAIDVLTKVVRNEGLFALWKGFFPYYARLGPHTVLTFIFLEQMTSAYKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EES5</accession>
    <name>A0A232EES5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005260">
        <property type="protein sequence ID" value="OXU16812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EES5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="11050" checksum="E77947403AD66A6C" modified="2017-10-25" version="1">MSSFFTFYLDSVYLDGFRLTSVGASVVVSWTPSGPGGSWRLRLSHADVAGCSGPLDDGGGLAGFLPLVGMVAGSSGRWHFRVPTRCTCNTLAHSRTLLGDSPNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFN5</accession>
    <name>A0A232EFN5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004969">
        <property type="protein sequence ID" value="OXU17157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFN5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="199" mass="21741" checksum="EF3477E2EC6B331E" modified="2017-10-25" version="1">MYTQSCSWKSPSKEALEQHHQNPQYSPTNTTTTMPYSPQFVQLNNDMSIDDDDDEILFSTFDLEYYNRVLKMTVGVSNDETNDYDEILKSLPTPSAPEPCSSSKSESSPNPSVPITPSCITPALSFPILYDALTNPLTKSSPTNIPLPNNNNKNELLIAGCSPLSSSSDFSDVENEDKFLGAAFLCLVGSSHTGVITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHM1</accession>
    <name>A0A232EHM1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004467">
        <property type="protein sequence ID" value="OXU17856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHM1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="197" mass="22543" checksum="35EAC22C86E842A3" modified="2017-10-25" version="1">MKNKLKKLEKAEAKENEASSLTMKTLQCDNVHATINYDTEQSICSIEPPCTIPSAKRTLDNLVALGHQSSSDLPYELSEPFRQTALDGTRNENYDFGKQSICSIEPPCTIPNAKRKLDNLVALGPQILIYLMNYQSLFDKQHWMEHVMKIMILEPFRQTALDGTRNENYDFGSTLLEDYSVDDSFYQSLTDMLHMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI41</accession>
    <name>A0A232EI41_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01004334">
        <property type="protein sequence ID" value="OXU18037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI41"/>
    <dbReference type="STRING" id="543379.A0A232EI41"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="324"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="685"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU18037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="750" mass="85290" checksum="60612294839BA576" modified="2017-10-25" version="1">MSSTTVDRPAKTGMTNKKENENNTKARRISNASHKKHKHEENRHFKFGRKRLQSFTGNGKFCPPYKRRKKEGAIIPPTKFLLGGNICDPLNLNSMQDEEINRAMNAVTPKSSPLPTPKHRKEAIEVIIPPNICDPLNLINCNDNDEYEKQLISPVKKPSKKRNRKRKRPSSAGRDDTNKESAEIKDSISIEEAKVVENVEANVVVEPAKNESPSKPPPLPPLPSQEPQQTKMEKPPPKEKVKLRLKGLDEIKDKRIKKLDVKDKIVSPVIPQPGAWKPRLPHRPNQDKKKKAQQQPKFNSKNARFQFGNYNRYYGYRNQHQNLDTRLTVFTQRKELFYGKDILDIGCNIGHITLSVARDFSARSVTGIDIDKKLINIARKNVKHYVNCVQSPASTEDGERKEYDANYFPTSMLINYGPVDIPGFTKHNDHKGFPYNVTFVQGNYILEDDALLSSEQPQFDTIICLSITKWIHLNFGDAGLKQSFKRMHAQLRPGGVLILEPQSWNSYSKKKALTEKIYKNYQSIEFFPQKFTQYLLSAEVGFRKCEVVSVPPHPSRGFQRPIYLYTKADDVTSPAATATTSETAASASTTTPSATNDSAMDVSIEDCSTSTAARNERRQSLEQQEYQRREYERELFSVEPRKEPWETEISPNEQSTSQRSGESFGHYENLENVYAPSVTPCYDTPIHNVDSNPPDPEKMCYLDVKIEHDQSESNHVAENGNKTSPTAEEDQQQRPDGGSSELTEQQEDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIK5</accession>
    <name>A0A232EIK5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004251">
        <property type="protein sequence ID" value="OXU18148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIK5"/>
    <dbReference type="STRING" id="543379.A0A232EIK5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16985" checksum="0CA74FA451885F76" modified="2017-10-25" version="1">MKFISVILQRYTYLLAGLTLGLRISRNEEQLTTVVRRGGRVIRDANPTIIKAELPTFSTAACDRPMHFLSSLSKYLEIVDPSGINYKFIISQAMKGPALDWLKHIEARVDSVNKFRERFTSRYWNSSIQAAFRRELEFGFGICYSAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ44</accession>
    <name>A0A232EJ44_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_010302</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004090">
        <property type="protein sequence ID" value="OXU18387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ44"/>
    <dbReference type="STRING" id="543379.A0A232EJ44"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="787"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="420"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1019"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1019"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1049"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU18387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="127336" checksum="1DAA251D1C7E5446" modified="2017-10-25" version="1">MGVLGLWRLLDATGKPVPLETLEGKVLAIDISIWIHQVIQGYQDRRGNAVPNAHLIGLFNRICKLMYFKIKPVFVFDGGVPLLKKNTIATRRKLKSIAASKAQKLKNDLINNLIKHTAVKGALEKGNNDGESSVAQQFKDATAIPGSSKVQDMYKLPEMPSTSTCGDSDDYMDSDDELQTQLSPRKQTKWMGNIHSVDVNTEEFKNLPADVRYDILTDLKETRKQNSWGRMHELPAGSNNYSGFQVKRLLKRRYVQESLEVAEKEMGGKTLTLEELDRLLTDQGIETTQKQDAAFRIASDSTTRVVYVKDKPALQNNEESNDSSKSSTSKPKEQEDNTNDVHVDSMSIRSDGSLTIVNDIGAYDLDEDWNSDEDFTETSINDSHLLAKNGISKSVMNPALSYMLENSGFTREEILKIVEQSKKNKKKSDTNSSHSSTKRGKRTPSRLSLRNKSKKKKLFGSTIAESPKTRKEIINEPETIQIEESNSESDDFVEVPESLTNVSKDKIKKDENDDTERTIIEQSSSESESDDFIEIKDVPIPKSLGNKNVNNAFEITIKADEELQDDIFADIFVNVNPVKDNNVKIENVSIIDETVHNPSHNSSPEKSIKKQESIEVEVKMNKSIDEHDENGSFSMQFSSDNLQLDSGIMSLPTTPQKICLVVEEKSSPHSENFAHEENCIENKTETEVQKTSIETVNDKSPVKSQNISKIDDVTLFSDDFQEISDKEEAGVEKLPTLVLPTDEKELESMKNQLESEQQKITGSLGKLERQAIDITDQMRLEAQELLRLFGVPYIVAPMEAEAQCAYLEQIKLTDGTITDDSDIWLFGGHCVYKNFFDNNKRVLQFLSQDIEHHFKLSRREMIQLALLVGSDYTNGLAGVGPVTALEILAAFPTEGEDILRGFPSQAVVQAYLSPTINESKEPFSWSKPNLVLLADYAKQKFGWTKLKFEEIMNPVMKRLMESKSQMGIASYFKVHSVPKSIEAVLSKRVQTAVQKLGGKIDDAEVSDGEASSTITLGKAKRVKKTTGKKGKKSSDESSELPTIAEAGNDESKAKATEDTAEQTKDTISIKVKPRKFVVVDEEVIPQRERDKANALKSKLRAIEIFRKSKAGLNRVQKKKKVVKKIKEDAELSESSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ84</accession>
    <name>A0A232EJ84_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004060">
        <property type="protein sequence ID" value="OXU18427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ84"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="8839" checksum="9DB74E58128743F4" modified="2017-10-25" version="1" fragment="single">MENLIELSSNDTLSNISKSFDYYYKRDTLQVATQILGQTVTQYKLDTEIITDAILFASQGAINPRFLSPDLIYKSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJB6</accession>
    <name>A0A232EJB6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004074">
        <property type="protein sequence ID" value="OXU18412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJB6"/>
    <dbReference type="STRING" id="543379.A0A232EJB6"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000002">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="26703" checksum="B28625FC0B63BA9F" modified="2017-10-25" version="1">MPKSKRDKKISLTKTSKKGLELKQQIVQDVRTCAEKYKNIILFSVENMRNSKLKDLRVEWRGSRFFFGKNKIVALALGTTKESEIAEGIHILSSNLQGQCGLFFTNEKKIKVLQWMREYGEDDYARSGFVTSETIELPAGPLPDFSHSIEPHLRQLGMPTSLQKGVVTLLKDYTVCTEGQTLTPEQARILKLLGRPLATFKLTPLGIYTKKSGYTQLADQLVQSNGKENSEQDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJX2</accession>
    <name>A0A232EJX2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003914">
        <property type="protein sequence ID" value="OXU18660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJX2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="11666" checksum="3C6A7FF293DD485E" modified="2017-10-25" version="1">MGFCYDDKKSQVFCYYCGVIISPLQNEEEIWTNHAFLTTDCCILRNQMGEKAIQEAREKYKRHSNETGRKREKTRDGEIERDFSKLTTTKLNNQQQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELC0</accession>
    <name>A0A232ELC0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001554</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01003583">
        <property type="protein sequence ID" value="OXU19153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELC0"/>
    <dbReference type="STRING" id="543379.A0A232ELC0"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="498" mass="58453" checksum="DB1C44EB6CA19507" modified="2017-10-25" version="1">MYQARDKVFWFAILSRITVLVLQMVFNAICPDHNADAFRMPIDPTEKHSYLDDIVTFIFGGLTRWDAQYYLHIAKYGYTYENTLAFFPLFPMLMRFVAMVFQVEPPILNYTSTIVISGFVINFVCFVKAALILYDLSELVFKNTKVAYRAAILFCINPASIFFTALYSESMFAYFTFYSILESLNNNPCVFFPLGLSSLVRSNGLINIGFPVYVWIKSMLVTSIPNFMLEFIHYHGNNSSLFFDLRHIFISIAHVFFMFIFSVLPFLYLQMYNYVRFCKLETNDTMLPYHVQQYAVDNNLLILGKTEFPWCNSKIPIAYSYIQDKYWNVGFLRYYQLKQIPNFVLAFPILYLMLKCSIEFFKEHKSKFGTSEFFTGIAKKQKSDNEKYPLEMFVFVVHGLFLTIFCIFFVHIQVSTRLLCSASPLLYWFCALVTMPKSKLSKAIKEIEYDSQENIFSKWKVFFLTQQEYSSVEKIIFGYFSAYVIAGCFMYSNFLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELR0</accession>
    <name>A0A232ELR0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED8</name>
        <name evidence="13" type="ORF">TSAR_002751</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003517">
        <property type="protein sequence ID" value="OXU19289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELR0"/>
    <dbReference type="STRING" id="543379.A0A232ELR0"/>
    <dbReference type="OrthoDB" id="150687at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1710:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU19289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="255" mass="28187" checksum="D93177D7E35D53E2" modified="2017-10-25" version="1">MQREEKQLDSALEAIIMRVNDLKSAIASMIFKVEHEYETLNWPNFLDNFALISGHLTSLSKILSNEKAPNLRNLTVLPLHLSPEKDEELLRMTEGRISTFAHDLVPDYLRTKPDPLVESKMLAYEAKVANLTYDAAHKQVAQYNKVINHVWDIANKAREEWESETGSRTTQTQTSSSADTHLLVYAVGNGKGLKSDAVQMVQPGVNQVGGNMMVGRPGGQPQQPGQGPMVGQMGKAPSAIKTNIKAASQIHPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM50</accession>
    <name>A0A232EM50_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_008425</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003450">
        <property type="protein sequence ID" value="OXU19398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM50"/>
    <dbReference type="STRING" id="543379.A0A232EM50"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06086">
        <property type="entry name" value="KOW_Spt5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000013">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000016">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000017">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000003">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041980">
        <property type="entry name" value="KOW_Spt5_6_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057934">
        <property type="entry name" value="KOW_Spt5_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23288">
        <property type="entry name" value="KOW6_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23287">
        <property type="entry name" value="KOW7_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="13">
        <location>
            <begin position="256"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="15">
        <location>
            <begin position="869"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="1108"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="760"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="853"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="869"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="942"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU19398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1160" mass="126510" checksum="D638638866B3B6C8" modified="2017-10-25" version="1">MSDSEESVYSANESNHGGRRGEGSDSEYHSVKSGNASEAGSAAGSPARSRSRSRSRSVSRSRSRSVTSRSRSQSRFRSGSRSRSGSRSRSRSRSRSCSGSRSGSTRDDEAEEANSEEEPEPEEEPEGEDLDEYDEEEEEDEDRPRRKKKKKGQVYDFIIQEAEVDDEPEDDEEWEEGAQEIGIVGNEIDEIGLTAREIEGRRRGTNLWDSQKEDEIEEYLKKKYANESAAAHRFGDGGEEMGDEITQQTLLPGVKDPNLWMVKCRIGEEKATVLLLMRKFLTYQFSGEPLQIKSVVAPEGVKGYIYIEAYKQPHVKAAIENVGNLRMGIWKQQMVPIKEMTDVMRVVKEQTGLKAKQWVRLKRGIYKDDIAQVDYVDLAQNQVHLKLLPRIDYTRPRGALRTAQSESEAMKRKKKRRPPAKPFDPEAIRAIGGEVTSDGDFLIFEGNRYSRKGFLYKNFTTSAIIAEGVKPTLSELEKFEEAPEGVDLELSGAPVTGVSAGKEDSITHTFSTGDNVEVCEGELLNLQGKIVSIDGNMIMVMPKHEDLKEALEFQASELRKYFTMGDHVKVVAGRYEGDTGLIVRVEQNRVVLFSDLSMHELEVLPRDLQLCSDMATGVDSLGQFQWGDLVQLDPQTVGVIVRLERENFHVLSMHGKVVEARPQGLTKRRENRNTVALDSQQNTIQKKDIVKVVDGPHSGRGGEIKHLYRSFAFLHSRMFIDNGGIFVCKTRHLQLAGGNKINAASAMAPMISGFMSPRIASPMHPSGTPAGRGGGGLGSGSGGAGGRGRGRGGPRRDRDLIGTTIKITSGPYKGNVGIVKDATETTARVELHSTCQTISVDRSHIANVGVPTKDGGFSSYSRTPGYGAGSQTPMYSGSKTPMHGSQTPMYETGSRTPHYGSMTPSHDAGSRTPGQSGAWDPTVTNTPARTSDFDGYNIEETGSPGYAPGYPSGGPFTPQTPGTMYGSEQSFGPYQPSPSPVASATASPSPAAYGSTPSPAGTGYTTSPHGAFASPSPMGYSPMTPGGVGSPYNPQTPGSIVDAGHSGVFGQEWHTTDIEVRVRDSNQDADLAGQQGYITTISGGMCTVFLPREDRSVNILCDQLEPVVPSQNDRVKVIIGEDRESVGTLLSIDNQEGVFKSNAGEVKMLQLRFLCKMRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMB4</accession>
    <name>A0A232EMB4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003383">
        <property type="protein sequence ID" value="OXU19503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMB4"/>
    <dbReference type="OrthoDB" id="10670627at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="580" mass="62517" checksum="AEED56CF4CC54BF5" modified="2017-10-25" version="1" fragment="single">VIFIAVVVAAEASRAPRAFDSEYREFPPYIESPTPPPRPSFLRSFSRHESSSPTFYSRPQSLSDRESDIFGEGPPSRPPYREGRIFLADSPFSSSYFLSSRPESFDWEGPTDFREGQVITYEYKGPPPPLPTKDSRKQAFGPADKQASGDPNNEHRATKPKEDQNNQQQEHRTITETRQPLSFGGHSSHLSFGNHGLGFASVADVTSVDINPLAVAQLTATTKAAAATALRTSASTVSMQSSSTSGIEVSRQHPSTNPTSSESPTSAAATSPSLKIAGAASSQAAQSTFNEVASTTPTTTTSKNPSVTPKFNFDSGHRINGATVKYYVSPKTAYDLRAIAHELPAPTHGLLPIESGKQQLQLSGIKQNLFFYDTKNSQPFSNEQLQQIQQQLHGQNSDSNVSPVRFSIPTSLIPTNPPGTGQMKLTYSPVDFARSPLSLPAVPNAYTSGQNHIDMTQLKLNSAGTSGPSNPSYYFIQPQGQAKPAAQIGSTIPLGSFYLLPNNVQAKQPIQQAVQVNPGISPGLQLQLSGFGGIEYLVSSSNPEQMRPAGIDAGKGIALQEQYRPAETMLTKIGFGQNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMM2</accession>
    <name>A0A232EMM2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="1"/>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003334">
        <property type="protein sequence ID" value="OXU19605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMM2"/>
    <dbReference type="OrthoDB" id="7648950at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="255" mass="27725" checksum="64FE60AE18FABF7B" modified="2017-10-25" version="1">MAAAQNAQDEIPYSLDSVFDDLTDKDKTVEMMGYICSMTATQTVGNGYSLMKFVTNGNKKVTCLLWGQSLIDIHVSNLIINKKMHLDGAHCKMAILKFNQEQDNFVPFELNIQASTVVNYMGMHEPEEAAAVDLQPEEVTFETINRATGLMAINGFVKMKFISMPSRFENACYGCGSITDGVYKITVNISNFVPKDDLSKGDAVSIIGNVNVPNNAMLNISCSDMNSITSSENVPAMSESDLAIGSSTVKSTSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMP7</accession>
    <name>A0A232EMP7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003317">
        <property type="protein sequence ID" value="OXU19635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMP7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="81" mass="9352" checksum="0229CF613BA45E51" modified="2017-10-25" version="1">MSTNIPARLRFVVRYNTVNEEVLRLYEEMPLYLTCYDSEFTDSQVKPAKIQCLLNNRADIDLENDDANARSPSSTLARTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMQ6</accession>
    <name>A0A232EMQ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (32-2'-O)-methyltransferase regulator THADA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003311">
        <property type="protein sequence ID" value="OXU19645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EMQ6"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF7">
        <property type="entry name" value="THYROID ADENOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="5">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="4">
        <location>
            <begin position="359"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="6">
        <location>
            <begin position="656"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1322" mass="152303" checksum="6F4A7E07331A42A4" modified="2017-10-25" version="1">MNCETLKNTNDLTILLAYKQRKKNGTLDLDEHLKGQETKWRNEVEYHLLEHWLTCDCEELRISSLETLAISKKSTLTFTEQEIGLIKASVKNNLGERGEYVPLIKKILKRLNDSYAVLKRQLEKEIKLKELQKVHPDLVIPTDELNAQALAPCYQEFVSFLHNICLDNIYPEAVNVRKKASLQILSLMDEFLGKDLKDGLWSQDQFRKLFECLLLDTYELNKEMAFKLIKSYNLVESYMDKQKLVELVDVAIQLGNSIRPLDSITAAYMLKISMLSSNIEEILYNKINLENNSCTQEKVAFYMVTLLKENLEKPVKLATENIVIASSKHSLYGYVFCIHSILSTINLKSKVNEECWRNVLADVINMCFDLNKAVSQIVNNSSPEGHLPMDLNPRHLDGMIECMDEVVITPQMVLLCSWRTVKEISLLFGHLTSNATIFNEKAGTGLLSEAQIKEIGNQLVTLLCETKHRGAFEQAHVGFGQLCSRLWHLDKGEAYLKELPKMWLQQLLLAVIGFTSENSKLCATRRSAGVPFMVQALVTSQIKKKCDLQALVFHSVMRILLKLVNVGNDFDLNEVENILFSETLFNGHRKPQLFNGLEKLEETSKLNEITEIKSHALNILRALYRHCLLGDLVKDYIAEGFIVAFKCYDGESWAERNAATLLLSALVVRVFGVQRTKDHVNLTLHNRMTGKKFFEKFPTLLPFLLNELEIFINDPEKQIKPKIQSILLILSRLYPSVSSDDSDEEAKKGRSDEGWKIDEFIDLVSKCGKSKVYKTRELAARALVPLLTDDNILSIASNLIDSMTTNEIPLNLLHGYSLQLLEIVRCPEFQNVQLSTEQIRTFINFLTKNVLHNLESTNCGPACFPVASVTLEIVIQFSLMEKYCRFYEQDWILNLIDKVQLHLTDNKILKRRPEIQRYEHTAVNLMVIAINNFYYKGPLLVNEYMAAQFWESVLKHTNTDVLTTCWTKLMIIIKKTRSPMLYDLAFMTAVRSLDKLVEDPDLQDSIYAFLYSVVQRMHETYDYMQYTFSKEEEKKYMCMHIFNKLSSQLKMETFYPRGEFFKLFGKTFGLLLEYYKDTEISTESKMIIYDAFLSQSSMESNFDCRLGVSEVLFDLYLDISKKDDIYYILNWWTTVLNLLYDDNAEIRRNAAEMACRLPPESRLMSHVIMTDTFFGKFTSVVGQNLEALVAAFFVWSITSAAVVLEEMDETDVFNKSCNYETFEPVQITNYCVKYLNTVISRDNLPTTLSKPIKAWLQKQLNLDYEFDTLSELIVKYKSQIPSTEKPLKRILDPTYPAKLVKEIAYNELKNVLMRENGLAPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN50</accession>
    <name>A0A232EN50_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003238">
        <property type="protein sequence ID" value="OXU19751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN50"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="19844" checksum="EECCD662A87BBC8D" modified="2017-10-25" version="1">MASEYNSTLYNKRRKWTFPSEDDRAPDAPETDTSAQTSSESGKAHSPLVVHRAFYNKCIRKTIFVAYEVDREWRCPILIDTRKYLVKEVLNRKNARNQDCRILRMKSNNDLRFDLESVFKRQWKERKILRSKQWSLISDMLCLYFKGNFNRYRYKFGVQDPQLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN86</accession>
    <name>A0A232EN86_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003191">
        <property type="protein sequence ID" value="OXU19833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN86"/>
    <dbReference type="STRING" id="543379.A0A232EN86"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="631" mass="71883" checksum="1B8ADA2017E2E0AD" modified="2017-10-25" version="1">MANEEAIEELLRSFHDMAIDPYNASYIKKYDRMLHGALRDIYLKNFRNFARVELRAELRNILDQEVIVSSFFKDQFERLPILWIAVLGCYQKSAKLLVRTKIVNINEPFPLPETYYAHVELNPGTTILHAQLQMYPSWLSDSIVRHLVMEGADVHAQDNLRRAPLHYAMRSGRTSDLIKIFLDRRVNINVTDYRRETPLLLAIDNIRADDRVVPLLLRYGADVLAQDERGYNVLHRIAETTKRDPQRAADLARVLMDKGASLQDTTVTYRDTPLHLAIKMTDVNLELIQAFLERGADVNIANRSRLPPLHLAVGCNQAEKLVKLLLRYGANVSAKGAKRFNLLHQLAIAPREHVELANFLIGQGVSVFDTDEEYLCQPIHLAAFQGKYDLVKFFLDLGVDPNVTAAEGVFPLWLAAESNATDVLIILLQRGADYEKKTSNGRTALHKACLSHHADSIKLFLCIGANIFAEDNAGATPFAVMMEHSQGNLNTRLIMLKELALKKMMLSIDRLKDESIINNDPVLLENFQKCIAQLEEMRNTRRILLTVLTKSHRKLALLVRNADFVAEFRSVDLGPFPMYAKEITLAFERAQCHHLKMLEQEEVIDQAFYKTLPDVLTRKLIGYIFNDVVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENL4</accession>
    <name>A0A232ENL4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diacylglycerol kinase</fullName>
            <shortName evidence="7">DAG kinase</shortName>
            <ecNumber evidence="7">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01003124">
        <property type="protein sequence ID" value="OXU19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ENL4"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.110:FF:000008">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000003">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.110">
        <property type="entry name" value="Diacylglycerol kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029477">
        <property type="entry name" value="DAG_kinase_typeI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038199">
        <property type="entry name" value="DGK_typeI_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF48">
        <property type="entry name" value="DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14513">
        <property type="entry name" value="DAG_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="9">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="604" mass="66358" checksum="5B8C19D5E9D63E0F" modified="2017-10-25" version="1">MALQWDKLSPAEFQQLQDLAAYSSRKLQDVLLEFCAASTPGGVPKYHPDGDIDYEGFRKFLDTYLDVTTPDELSRHLFLSFVKRGPRGVDGRAFKEMAVLSSTTACAAITSHTTSSSNVNSTGMGSGAXXXXGGAESHGSSLADKIHGLTEKLQALGHHRTDSEASSRIRTGSVHPMLLVTHTSYSCHDVLEKKSTDSSPSHSQMSRNSSRKSNNSLLVNNGKLEAASPLPPSXXXXXXXXLSTGPSAQQPAMSFQITPLPNTTPLLVFINPKSGGRQGERMLRKFQYILNPRQVHNLAIGGPMQGLQMFKDVENFKVICCGGDGTVGWVLETMDRVQFEHQPAVAVIPLGTGNDLARCLRWGGGYEGEAIHKVLKKIEKATPVMMDRWQIEVADQSDEEKKPNQDSIPYNIINNYFSVGVDAAICVKFHLEREKNPEKFNSRMKNKLWYFEYATTEQFAASCKNLHEDLEIICDGVPLDLAHGPSLQGVALLNIPFTHGGSNLWGEHHARHRIGKRKKRPDKELSTSSFNSVDLTAAIQDIGDNLIEVIGLENCLHMGQVKTGLRASGRRLAQCSSVQITTAKRFPMQIDGEPWMQGPCTVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENM9</accession>
    <name>A0A232ENM9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003127">
        <property type="protein sequence ID" value="OXU19937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENM9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33333" checksum="CB8D8B628C69748C" modified="2017-10-25" version="1">MSTYQKKLRMIKMYISYGDQQETLRLIKRLVPTMLPTEMTMIIYQCILGEKIKIIEYCLDNPYELRLLRLCTNLVDLAVESGSAKSVETILSRKINDINATDGKGQNALLIAYKTNNYDKINLLLRYGAECYPPKKNKLFQRDRILTRSSYLEKPVNRVKPDRNDYEDFVDKYVRVLNGETPSQVLELNALLWQFDIDLTYQRVRDNIKIIEYCLDNLYEPRLLRHCSWEGTNLVHLAVESESVKAVETILSREINDINATDGKGQNALLIAYKTNNYNNMNLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPQ5</accession>
    <name>A0A232EPQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002927">
        <property type="protein sequence ID" value="OXU20286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPQ5"/>
    <dbReference type="STRING" id="543379.A0A232EPQ5"/>
    <dbReference type="OrthoDB" id="10025511at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000060">
        <property type="entry name" value="Protein phosphatase 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="701"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="957"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="968"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111224" checksum="862581FF920F4797" modified="2017-10-25" version="1">MPLSIGVNLRVTGHCNQGGRKYMEDMFSVAYQQSSNDRELEYAFFGIFDGHGGGEAATFAKENLMDIIVKQKNFWSDNDEDVLKAIRDGYVNTHYAMWRELDKWPRTASGLPSTAGTTASIAFIRKGKIYIGHVGDSGIILGYQEKGDPLWKSKALTRDHKPECCTEMTRIQESGGKVVSKSGVPRVVWNRPRLGHKGPVRRSTHIDEIPFLAVARSLGDLWSYNSELDTFVVSPEPDVKVVKIDVKSHRCLIFGTDGLWNMLSPQAAVAIVQAAEKHNEKHLIASQQTGNGQNDAQMWINPSKSLVDRALDRWSSTRLRADNTSVVTLMLDPPGPTHSEILLSQKRDGVRPSVPIVEPEMVHNSFPSPQIRPPFAKPEPEIYNPFPRSPMTATKLPSYSELQKHPDSSNHLFENSTATTNLTNLESTSSGCSKYAAYLSKEEASTSNIIPNQSFVEPPQLEESIQVAEISSSNFSDEHSTTTTVTVSVEETTMLVSETEGTIVESTLCTEETRTTVESAAAGDIDVALEMAETEFLLEKESWLQKVPEAEKFTDEVENTDLQPIKFSEPPSGPRLRRGVHEPSGNSTKSTTTVTTPTNGPALTTRCMGSVAPISGIVIRQTSNSRRRHSTGAPPNNQRQQQRQRRSLTPKSSSAATTYLASSASASSNRLKRGSKVLLIGESGFDESRVGVGTRNTTECKYEAKDNSGNSDSGEPCLKRRTRSEDVRKMQDENDPANQKVDQQLSRLRWPGNESSISRTNGVLNSSTGSIQERRLSSPNSFKRRNLEKKVTPVKTIRRPSINRSTNRIQMRDSFWEQQGRASRTGASCSSSRRQTVVGIISSIAESVSASTSNSSSSSAPKRWLRSDTIAATPIKTLRSRNVDIAGHTVSAQVAHQHGAVKTNRIIEHATKLKQTTTPASTTGAAGSPVTPQTPVVAKVKSTNCVSTPVSIATPNRTKQSCSVSPVGGTSTSCASTGGTSTTPSATTSTVLISKRAKTPYNPSAISLSTRSRIKRFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPX1</accession>
    <name>A0A232EPX1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002868">
        <property type="protein sequence ID" value="OXU20415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPX1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="41" mass="4908" checksum="131417F8038ADF68" modified="2017-10-25" version="1">MLYWSRELTFKLFNLVHQYYAIKFGALDKKNQLGSRVSRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQB0</accession>
    <name>A0A232EQB0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002809">
        <property type="protein sequence ID" value="OXU20528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQB0"/>
    <dbReference type="STRING" id="543379.A0A232EQB0"/>
    <dbReference type="OrthoDB" id="10033734at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049041">
        <property type="entry name" value="RalBP1-like_Ral-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20924">
        <property type="entry name" value="RLIP76_Ral-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="163"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="675" mass="76860" checksum="01E0F48C1E906DF9" modified="2017-10-25" version="1">MDFESPDVEKEFPGLYASDAAKKSESDFSDDGVHDKHSKKELLGGSKKKDKKDKKDRGYATLEGESSADEEETKSPSKSKSKTKAFKFPSKSREKREKSREKDVKEKDSDKEKKKKDKDVDKEVDKEKRKEKDKVKQKHKDRKKGKHGDDALDIGEEEPIFGVSLHLAVERSRCHDGVELPLVVRDCIDYLEEHGMSVEGLYKVPGNKSKVQHLKKLYNQREPVNMSEFEPNVATSLLLHFIKELPEPVLESSELISRFEQAASTKELAQRESQLADLANHQLAECNRVLLAWITLHLDHVTTCEKTTKMNAQTIAMTLSPALQMSHRLLLALLFHCKALFPEVKLTKYVPPLPAGSTRLPETPQGIAAELAKQESLLSQIHMLMNAGYVNKSREEQLWEVQRMITQLKRKYKLVQKLEGSIQKSLDEEVPKPTEESQSHVPERQPHLQEKQPQLQERQSQLPESQPTKIAVKTEDESDRLKVSETSKEAPRRLSTENINHSAPLAEKDIVDKVSKISTDTTDSKTEAVHVASNKPEENAVAVESEKVEEPVVENETDRLRESLIYEELLNMQASLKTRISQERHEIERLNEMLLERISSGKSKAPVIDRTHSPSEAEMTAMIQLVSENQLLEKKMTTLIRSIVEEKDTCVELRVQLALHQLLMAQKNKNSIKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQB6</accession>
    <name>A0A232EQB6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002794">
        <property type="protein sequence ID" value="OXU20553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQB6"/>
    <dbReference type="OrthoDB" id="7664046at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="484" mass="54180" checksum="AEC2F324421504C6" modified="2017-10-25" version="1">MEVDPILSDDDIQILEVRDVNASTSHQSPKPEVKRQVAPKSNPVEQNIAKQLNYVNDLLTRTKNNIKIIEDVTDSILNNISVKTSYQEGSSSSESDSDCYSSTGEPVIKKRKNQLHEKQQVIKVNKVWQLVVHDKWIIGVVLQNTTTCDGFPERIDGSGGGRRSVLAGQGENEEGEHARGQERTAQTGKDVPAYRHLLLWYTAALSSILIPDCRQDKLQEPTIYICHNNEEDSNGVFVFWTLLDDKIWIPTDEIGPQEEVIATVVLDLPSFDEKPVIQAHGTVFCQFDDKLFQTSLPDLELGVENTVDGSCDIDFEDENRARASVLALKVRCFDFARVSGLTINASSLFPMHQAISVDRVVLLPMQVNAGTRKRLTKFLDAYSFTEVCKVCVMRNVGALQYCLLEVLPIEDADIRVLLSARSEAQLSAIVQLMHEYLPELLDVEKQQAVDEAADALQQELLLYLTCNSTAELQRAKIRSDLLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQE7</accession>
    <name>A0A232EQE7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002810">
        <property type="protein sequence ID" value="OXU20526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQE7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10573" checksum="6D65674FD20B937C" modified="2017-10-25" version="1">MRKTREKYRVFEANVILTVMLVVWQGAARRCLCSSGQRTGQSYQFRHQQQQQQLHLSRGSVADKLERYQLADNRLSYAWERKQKINQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQF2</accession>
    <name>A0A232EQF2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002775">
        <property type="protein sequence ID" value="OXU20580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQF2"/>
    <dbReference type="OrthoDB" id="6819088at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="234" mass="26058" checksum="CF1295605BE926DF" modified="2017-10-25" version="1">MSALTLVLQQLPGVDADEFRNLRSYYACGKSYREALNGKRRTRSSPSTSSTKSSSGVSSPSDEDIDKPSATTTSKSLTSSRKSDSGVSSPSDEDIDKPSSTTTSKSLTSSSKSDSDDSSPSDEEVAESSTTTSEIHIDDEKEAPLKVKISKESDKPKETCTNNLRIMYRGRDILNLERNAQPYKWQLTSPLFGFYQKFSIYKNFSRHQNFESFEEYKMNACGICDFYEPVSDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQJ5</accession>
    <name>A0A232EQJ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002771">
        <property type="protein sequence ID" value="OXU20597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQJ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8061" checksum="72DA3FDCC5AC6BF7" modified="2017-10-25" version="1" fragment="single">SEVTTRRRLALLQTGALEPPKNPGPLKQRRFSEDYRRDSKHLAVTDRPVSLSALRVTLKIRGVKLLEGVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER88</accession>
    <name>A0A232ER88_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_015234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01002641">
        <property type="protein sequence ID" value="OXU20883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER88"/>
    <dbReference type="STRING" id="543379.A0A232ER88"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090433">
        <property type="term" value="F:palmitoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000026">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="109"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU20883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="707" mass="78898" checksum="15FDDD2324011159" modified="2017-10-25" version="1">MDNLWVTGAVSAVKALSYVYDLFTFPVYLILQRPWDKRKASRRIKAKPVHKDEQSILYRNVDPIGQMHATLVREKIDTLEKMLKYVASIHGNKRCLGTRQIFAEEDELQPNGRVFKKYKMGEYRWKSFVEIEKLATTVSRGMKELGLTVKKNVVIFAETRAEWMVAAHACFKQNLTIVTIYSTLGDDAIAHGINETEVDTVITSYDLLPKFKRILQKVPEVKNIVFMEDQLKEADVTGFKEGVRIIPFQEVVKVGSTSTATLSPPTSDDTAIIMYTSGSTGVPKGVILSHKNVITTLKGYCDAVVIENDDVFLGYLPLAHVFELLSESVCLLNGVPIGYSSSLTMIDSSSKIQKGCKGDASVLHPTCLTAVPLILDRISKGIAEKVKKSGPFRQAIFNFAYQYKLKWTRRGYDTPIFDKFIFGAAKQVLGGRVRLILSGGAPLSPETHMQVKLCLCVTVTQGYGLTETCSGATVMDPYDRSYGRVGAPTTVCDICLENWEEAGYRVTDVPHPRGEIIVGGDNISAGYYKLPDKTKEDFFFKDGKQWFRTGDIGEFHPDGAIKIIDRKKDLVKLQFGEYVSLGKVESELKTCQLVENICVYGDSSKNFTVALVVPNHHHLEELASSIGVTATSFEDLCNNSQIEKAVLQTLVEHSKKCNLQKFEVPGAVKLVTESWSPDMGLVTAAFKLKRKAVQERYKNEISRMYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERN5</accession>
    <name>A0A232ERN5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_011316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002575">
        <property type="protein sequence ID" value="OXU21018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERN5"/>
    <dbReference type="STRING" id="543379.A0A232ERN5"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF34">
        <property type="entry name" value="PR_SET DOMAIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="311" mass="37122" checksum="A0BA0BF0558BF99D" modified="2017-10-25" version="1">METESKNVNFYQTDEKISKKLYKCSFEGCKLKFSKPSSLKFHINVHLKEKPFKCTHDDCDKAYSNPSHLKRHVLLTHDNALKLKIRCEHCQEYFSNTSNLKRHIQRTHSDTAKFCKLCSRRFKSPSLLNEHMILHKEKGKELNSFDCDQCGKELKSWYSLIKHKRRHLKNKLQCPFEHCLVEFDTGTALKDHKVYFHAKEHADHKEIHKNYTCADCGKVFYAKNNLRVHVPTHLVQEKEFSCTYKNCDKIYQFKRNLKKHIQISHLGRRFTCEVCNREFKSNQKLNQHKQNFHQGPTKSRRRRSKIKVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESG6</accession>
    <name>A0A232ESG6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002423">
        <property type="protein sequence ID" value="OXU21303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESG6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12047" checksum="8F6BB115E8796481" modified="2017-10-25" version="1" fragment="single">ITLLKSSNDRVLSCARANAFHHSTLWPGSHRFSFSALKVTLKIRGVKLLERVVAPQIALSIRAYESQMTEKRSYRINTLHLLLSLVALGYVRNKLYNGILVGKPDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESP4</accession>
    <name>A0A232ESP4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_015105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, RPL24.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002392">
        <property type="protein sequence ID" value="OXU21378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESP4"/>
    <dbReference type="SMR" id="A0A232ESP4"/>
    <dbReference type="STRING" id="543379.A0A232ESP4"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="171" mass="20425" checksum="297D91970B0A91ED" modified="2017-10-25" version="1">MRIETCYFCSSRIYPGHGIQFVRNDCKIFRFCRSKCHAAFKKKKNPRKVKWTKAYRKTVGKELAIDPTFEFEKRRNTPVKYNRELWTKTVEAMKKVESIRQKRVNAHIMQRLRKGRELEKERDIKEVQRDLALIRSPAAGLKERKKLEEEEEEDMKVDSDVEMEAQAIEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETB2</accession>
    <name>A0A232ETB2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002295">
        <property type="protein sequence ID" value="OXU21599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ETB2"/>
    <dbReference type="OrthoDB" id="5872154at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15729">
        <property type="entry name" value="FYVE_endofin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000084">
        <property type="entry name" value="Zinc finger, FYVE domain-containing 9b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.220">
        <property type="entry name" value="Domain of unknown function (DUF3480), N-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.720.10">
        <property type="entry name" value="Smad anchor for receptor activation, Smad-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022557">
        <property type="entry name" value="SARA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024608">
        <property type="entry name" value="SARA-like_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037145">
        <property type="entry name" value="SARA_Smad-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319:SF3">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11409">
        <property type="entry name" value="SARA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11979">
        <property type="entry name" value="SARA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01421">
        <property type="entry name" value="DUF3480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01422">
        <property type="entry name" value="SARA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="838"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="734"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1578" mass="174891" checksum="D6A9C6C6F576F8D6" modified="2017-10-25" version="1">MEKFAVDKVLDEFDFNSDRAEQMPSASAPPMHPSMLPAMHSSMHPVMHPQMHQPMQGLPMQYGIPNVYHQPPMPAVNSELGMMNMMVDPSGLKGNEMNLMKEQEYLAAGNMDNLRKSELLVDNLDSINHFYTHDSLLDDKLQHKLNVNVGEAEPSALTIHNDISQKLPQKQPNDHVLINSYEKKLNQSHMQLGVGNVFNNFNEYMSAPSVSLLSLDDENVASNMYNTIPCEGMVNMTDSCMSSFVKHEKCSIDDLLTTEVQDMMDDKKDHNAAPPKYQNILLPIKLDTCNKSSETKTDGIEPDLEFPDLMTDTNQAVSAGFDKPDKVVKSILDEPEHVYENVYIGTDIPKTQQVFNNPLNKQRKVDPEIEHTYENVSFGTQSISSVPQDKDGVYECIYISNRDNLPETNTELEIAAKKMADHLNLKESESQNVCPIPSAASTNIKPVFQNVQLDSVQVPEPKSVIGFTEIDDMSEEELSKYLADLEAEERANERAAAVYENIAVDNNRENLKTSSLPIQQQDDEDANEAPIFEAVTIGELPQVPQQDLAEKAKKFPVIDYNIGTSSSSSSGEISNEFSCPKKPETAKISLNQVKADDESKVKKSKKTNEKVRKSSDNTEPTSQASSQSEQMSNNEDKDTEKDEENGNYVTTNESDDKQNNLDAKTLALAEENKNFNCTESTTSEQLDNTDVKNLQNNDQNIIITSDDNKLANTRTPVRNTETISRFSVTRNVDVNDKLGGRPIPSQSHNIVKHTEHSNSELDESSDDDPNRPSRPQTLNVVSTVNTSDSSAGACCNQETSDVEGDKDSGRVPSPDVSENSSMESGTVLGKQPPFWVPDSDAPNCMLCDMKFTVVKRRHHCRACGKVFCNKCCSNKLRLEYQKTIDSRVCIPCYLVLTKPESDTGSGDYAGFSTMNSTGINSPQGRPPNPNNPMEYCSKIPPLEQLAGGLPPAPPTVMVPVGVLKREGSSKQRSEGPKSVMFSDGIRPGCDLTELDTSWDWKGPSAAARNPVPRRTIGAGYVASSSNKKQNCPPIDAKTNSYIPQDPAALPPTVTIHKGQITYHQVTDPVSLCASLKNECEPPVMFAIQRNLFALVKIINLNCCVNRICWNVTSKGLACVGQDEIVFLVETLPDETQVPKDLLLHINLIYHEAAKGNTIPEYGMSIHQEGNLLGSREHVGFLFIRQTLQCLQKVIVPPAPFLVGLLVHRWETPWAKVFPLRLVLRLGAEYRYYPCPLVSVRLRNSVYLEIGHTIMKVLADFRNFAYTLPKVQGMTIHMEGNSTNVRFPKNRYNQVIKGLNNSNDHVLAFASNFSIQADSHLVCIQVAVNNEEDSGYQTQAINIQNKPRKVTGASFIVINGALKSSMGLSAKSSIVEDGLMVQIMPEKMEALKAALKNMQDFTIGCGKQGAPEPDEIVNIKWVENDTQFNLGVKSPIDGKPMDGIPSIRVHNGINYVGTSRFIRWTEVFIIKSDDDQPFGMHYPVDINKLSESIARATCTALVKLLDLLANAGLVKIAVRATIQPDNVGYEAGSEGTRLPPIYMNSLDNELVQVLQKAVQGCEDTQIVLELVFYVLETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETH3</accession>
    <name>A0A232ETH3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002272">
        <property type="protein sequence ID" value="OXU21660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETH3"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="375" mass="43517" checksum="B9D1561D44DCCB1D" modified="2017-10-25" version="1">MIVNKFTNKLVTIVPVTLIDIISYIDYLFYNFKVLKLFARLCALYPLDSGCSKLEIFYDNFVWYYIQFNLWTALVATFTAMYKARSDLSSWLNSFSESIIFIEIILLMILYRLQRPHLQILLQIFDDLIKDPDDFKLLLIRQSARKHLKGFSTVAVLFTMLAVIYVYKSFSTKPIQFILSGYYPYTSNSMMLWIIVLYHQLTILLYVPSIFASDFIVTLFVHKVNYVIRFFILKTIFCLGALQLGVGVILLRVCMHIKAIKKYDKNPDIPAITRIQFLVIFAITISRIYIYAHCAEILTKSGSDLGFAVYSSRWYIQRHNMVLAKSMIICRCQKPLVISVAGIIPALGMGYLGRFLYLIFSYIIALQAITKNHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETQ2</accession>
    <name>A0A232ETQ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002246">
        <property type="protein sequence ID" value="OXU21733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETQ2"/>
    <dbReference type="STRING" id="543379.A0A232ETQ2"/>
    <dbReference type="OrthoDB" id="3046016at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052267">
        <property type="entry name" value="N-DRC_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14690:SF0">
        <property type="entry name" value="IQ MOTIF CONTAINING WITH AAA DOMAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="600"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="866" mass="100015" checksum="5CD2356642724B7C" modified="2017-10-25" version="1" fragment="single">NEFLHGNIVEQQALPSSLATPALIQYKCSKKKKSNLAMSNTTYDELWREAQTLLEDVVQIDSSVQSIRSVRERAEARSQLADLYIRYIGIGNKLEECYDQVVQPQKRPLLRRLLDSTYGRVLELKHELVEVELSEYNYCDDALLRRRLTPDESELRVPRYFRREREKEIESRRKFIEETLRSLGELEEKPEPKKMTELEAIRSLQAHERARQGRVRFQFMKEILEMKERSTIRSEPKEPDTPTGIAAAVKIQKVWRGYVTRRKIRQRKLDEMLLIGMLQPCQSISENTKRLEKIEKERYEKQREFQEVFDAYTVEAKERIKLEKSAIMEENMRIEIRNWISTYYQQTGKIPELPSAESGGSRMIFSRQDTESSMSKSTGVSSSKESKRSKKSGKANKKESETEQQSEPESEIGFKPIPSNFLPELVQANLEYQEIWRDKDESANLEQEPYYDMIDAEKTREVENEIRVGVDQALRADIEALQAALDRDKGYKGKRAKKAQKRVRRSGKKNKRKKEKDLTPDRTTESLFEELLQQGIIKLYPEVRIDSFKGQNSFANFDLREKGKDPLPAIGDVRQIINEYCILPLSNETLRELTPLVRSVLIAGPRGSGKKMLVQAICTELGATLFDITPANVAGKYPGKSGLIMLLHLISKVSRLLQPSVIFMEGAEKPFVKKVPKTDKTDPKRLKKDLPKLVKNITNEDRVILIGTSRSPWEGDQKLLYQTYDKVVFIPRPDYGSMSLIWKNLLYKYSGISRQFDTSGMAKICDGFTIGTVMSAISEVMTTKRMVQLRVQPLTHIELINALSLKDPVYREEEDAFLNWYSKTPTCKKKQKAIEAELAKLEEANEKRKKGKKNNAKVKSRIPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETX5</accession>
    <name>A0A232ETX5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 2-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDK2AP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002209">
        <property type="protein sequence ID" value="OXU21801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETX5"/>
    <dbReference type="STRING" id="543379.A0A232ETX5"/>
    <dbReference type="OrthoDB" id="9628807at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017266">
        <property type="entry name" value="DOC_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607:SF3">
        <property type="entry name" value="CDK2-ASSOCIATED PROTEIN 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607">
        <property type="entry name" value="DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09806">
        <property type="entry name" value="CDK2AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU21801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17499" checksum="931CA93C59DAA697" modified="2017-10-25" version="1">MTECVDNFVADASAVIQGYNFSDALFRKKESDMQNDSDIKMEVTPKKIVEPLLTIPKPRPQIHQQLQQQQQNNHQQQQIHHQQSPKNSNGTTNMIHGTSKYNELLYVIGELGQHIRPSYTGHRGSSEKIRHGIIKARALVRECLIETEKSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUP5</accession>
    <name>A0A232EUP5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_006629</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01002107">
        <property type="protein sequence ID" value="OXU22064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUP5"/>
    <dbReference type="STRING" id="543379.A0A232EUP5"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07838">
        <property type="entry name" value="STKc_CDK4_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF472">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="133"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="HIT" evidence="16">
        <location>
            <begin position="476"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="11 12">
        <location>
            <begin position="568"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="10">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU22064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="584" mass="64239" checksum="7628CC6AC56747CE" modified="2017-10-25" version="1">MAGRARPANAEIDPDLSTPTAAKRSKLGATTDSSASQEDDSLKQTPLGSELGDLETSEVLPSSDESFGEDDDKGKIRIGAEVEAKEEGDSTAASSSTVTRVKKTQPSREATSGGAMGREAGLQSSLMGEHALYQELALIGDGAYGTVYKAKDATNGQVVALKKVRVPITEDGLPTSTLREIAILKQLDRFENPQIVKLLDVCQGNYLQLPAVDGMTDRITRGLTLWLVFEHVERDLSSFLTACQSRRLPPQLVKQMSREILLGVDFLHTHRIVHRDLKPQNLLVTKDGHIKIADFGLAKTYDFEMKLTSVVVTLWYRAPEVLLACPYATPIDIWSVGCILAELNELKPLFPGNSEADQLDQIFRIIGTPPESEWPQKVSLGWSAFPFRHSKPMETIFPNLSNAGLDLIKNMLIFNPHKRFTAARALQHPFLLKAVASASKQLRHVDKSFLGSVSNVRKMASEVEKAQTATPGGDTIFGKILRKEIPCKFIYEDDQCVAFHDINAQAPVHFLVIPRKPISQLSKAEDEDEAVLGHLMNVARKVAKQEGLDDGFRLVINDGKHGAQSVFHLHLHVLGGRQLQWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV10</accession>
    <name>A0A232EV10_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thyroglobulin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002067">
        <property type="protein sequence ID" value="OXU22177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV10"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF24">
        <property type="entry name" value="THYROGLOBULIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="148"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="237"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="452" mass="51098" checksum="A5336A32FC7C493F" modified="2017-10-25" version="1">MYILSSYFYFHYRIILISTLPLQCHFVVIYSFVSSSFFCKIMNLLIFAFIQLSLRSISTISSDEVDDYKCTKKFCEDFKETAACRAMSMTCRKNPNSTHLPFPDTCSCCDYCLKNLEEKDRCTVGRPGAVSPLEVCGPGLQCKTSKYETTCEEIESACTNAQKAYDKRKEEGTLGMAEIRPKCDTDGLYQTVHCIPGSICYCLSPDGHRIFGEIPYLDYEDEKKMTCGCSINAWKALNTLDPKHEISVARCTEIGTFDQLQCVKGENSTCFCVDSQSGSPISNTDIVFEEYINVNMPVCFDLSRHRPGTYSTSCEIEREVYLSYKEDEENAKTSLLIINEPFCQPDGKYDRIQIAGSKKVCTDMDGRQIDSYEADIADKTIDCNCARTRLVLSNAGVVELPTCCPNGNFEAWQYRRKQYFCVDNNGNQVGREYSSSELSKLDCYKKNEGSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVC5</accession>
    <name>A0A232EVC5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_001676</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01002030">
        <property type="protein sequence ID" value="OXU22268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVC5"/>
    <dbReference type="STRING" id="543379.A0A232EVC5"/>
    <dbReference type="OrthoDB" id="2107370at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000003">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000095">
        <property type="entry name" value="Adenylate cyclase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="20">
        <location>
            <begin position="483"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU22268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="685" mass="77104" checksum="913EDA2F78A922DD" modified="2017-10-25" version="1">MRTGSEDFLSLIPQQRFVREATGFNVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGLPGKVHVTKATLLQLGDRFEVEPGNGGSREAYLAEHKVETFLIIPPKKNKEDGELENGKLNRGPGPIPSRSRPSSKMTKYVECWGADKPFANIAEATLAKNIGLTSIAMIESNLLNNNSTCFDVKQWCGRREGMSSLTYWFKDTGQEHQYREQRDEQYPWYVLVSTLLYLIMFFVQTVYMPGNITIYGCFGAGLLCLSMLSAISWLASRNGKGRSSNDDSHIVSSSNIGEERVLLSRGIRISVYLITAVLAVASSVVSLVDVNPNWEKSMAPMYVECAAIALIVAWTHLRVGSLLKLSVMIISILTLLSIFSQCQVIQDYYYDPRNEFFKVHYLVQIGFLLALVGLVLHVLDRRIEYTSRTDFLWKNKLKVEQDEVETMRGINKILLENILPAHVAGHFLATRENQDLYHESYSSIAVMFASIPNYKEFYDETDINKQGLECLRLLNEIICDFDKLLLKPKYSSIEKIKTIGSTYMLACGLSPGKEDGDGLIDLTKQREHNVIVLVEFAISLMTLLDQINRESFQRFKLRIGLNHGPVIAGVVGAQKPQYDIWGNTVNVASRMDSCGEMGKIQVTEDTAKILRNAGYELICRGPTYVKGKGTLTTYFVKTPFDNKEDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVG7</accession>
    <name>A0A232EVG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002002">
        <property type="protein sequence ID" value="OXU22340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7701518at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="473" mass="53931" checksum="36EA629E5897836C" modified="2017-10-25" version="1">MASEKEDHQLQSSSPIPNASGNKSSPVSYSKITQINEFRKFTLTDYACAIGEIVKPINILNASKISNNRVRRYLSSQELLKKLTNNYKYVEINGIKVTIRPLITKLQRIIISNVCPSIPHFVLEEAIDNMKIKRNSTITSLRAAISKDGYSHILSDRRQMFINPEDVKKLPEIIKINFDETIYYVYPTTDAIRCFVSKREGHVAKQCPSINYNEITVPTXNMKIKRNSPITSLRAAISKDGYSHILSDRRQMFINPEDVKKLPEIIKINFDETIYYVYPTTDAIRCFVCKCEGHVAKQCPSINYNEITVPTQQVNRPEPIALENNANTINSSQIIDSTKDIERSANIATVPDNSNQLDTFFLAPNNFENQTRKPNKRPLSLSTTSSSLLGKTDFFSSSQSSLDAFSDEKSTQKHLKTKLDVKSQRNNTKKPKKDSEQLSDIEKEFNLIKTDIENPENKFPLNYTTLKEFLEKX</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW44</accession>
    <name>A0A232EW44_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001923">
        <property type="protein sequence ID" value="OXU22553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW44"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="140" mass="15496" checksum="FF54D5A5B1391730" modified="2017-10-25" version="1">MLELQAPMLESLSNRSLNGHLNDSNNNDDQDDDEESSVQQLTPRRLRGRLLQRKFKAKAAAAKAHLHQRAQNRSSAIARVWDTLATVRWSNSSGNNVKSTPVVQSEEAILARLELLRNAAEAGYRNDAGSNGTDDYLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWI6</accession>
    <name>A0A232EWI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01001855">
        <property type="protein sequence ID" value="OXU22709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWI6"/>
    <dbReference type="STRING" id="543379.A0A232EWI6"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF114">
        <property type="entry name" value="CARBONIC ANHYDRASE 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU22709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="274" mass="31756" checksum="D81ECCBF3B6B4212" modified="2017-10-25" version="1">MATENQLKTLSRKRQSPIDLRDDVARLKYLPPLTLIGHWLNDGEATLTNSGDYAVIELSGERIPSIVKCGPLNDEYEFHNAHFHWAEDDCRGSEHTINSTWFSMEAHVVHWNRKYRTFDECLKHADGLCILAYLFMVKDGKYCRSHSMLEKITDNLEDVVSFGATTNIPANSLCWMREAVRCDYYYFYHGSYNKGDFPECALWIVFPNVISIRSDQVGHLISFNEKENAQNFLLLKVAEFRKLQDAKGREIKSNGRKLQLLGDRRIYKVFPCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWJ6</accession>
    <name>A0A232EWJ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001854">
        <property type="protein sequence ID" value="OXU22716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWJ6"/>
    <dbReference type="STRING" id="543379.A0A232EWJ6"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15890">
        <property type="entry name" value="SNARE_Vti1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF89">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12647" checksum="98FA58AE8266E2C7" modified="2017-10-25" version="1">MTADQRRVLLESRAAIERGNQSVAKSQAIAIETEQIGTEVIGELGEQRETLLRAKSRLNQTDQELDKSKKILNTMKKRILTNKFVLILIILLEIAILGCTVYIKYFEKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWK7</accession>
    <name>A0A232EWK7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001849">
        <property type="protein sequence ID" value="OXU22732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EWK7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="966"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1224" mass="139167" checksum="04F3F54511DB99B0" modified="2017-10-25" version="1">MTTEKLRRNLRSSTPFALTMPKFNQIEKIETIKTPIYHGLTSTLRSGRSNYKKEIARINRLEQDFSVNEYISALNKQQLAKACQLNDLLWQSDTETAVKARNARSTRFFLKKGSNGSVITRKATDLFYEAIARGDEKVLYVIIEMGVKPSKNVCPFIIDLENKKANFIPILWTHGFKPSDPVEALRSAIRREDVLGFRWLYTRETPEGPMGFLHEAVRQGVSVEVIQQLIDLGYDYNERTPHGRTALQIAISGKHEHLVKYLIYRGEDVSDHVDNDGESNLFLALRMQNILASIMLLQNELSTKYMNRWEEKNREGENLVFQAVKARNARSTRFFLKKGSNGSVITRKATDLFYEAIARGDEKVLYVIIEMGVKPSKNVCPFIIALENKKANFIPILWTHGFKPSDPVEALQSAIRREDVLGIRWLAVKARNARSTRFFIKKGSNGSVITRKGTDLFYEAIARGDEKVLYVIIEMGVKPSKNVCPFIIDLENKKANFIPILWTHGFKPSDPVEALRSAIRREDVLGFRWLYTRETPEGPMGFLHEAVRQGVSVEVIQQLIDLGYDYNERTPHGRTALQIAISGKHEHLVKYLIYRGEDVSDHVDNDGESNLFLALRMQNILASIMLLQNGASLQEVNGKGYTIVYRAALDNDEELLVLTWRFGAPLYGPTGNPILDPRGGNESQRAIVRRMALINHLKGDVHPEDMATINSQVALLSYYHYCRQRTPHGRTALQIAISGKHEHLVKYLIYRGEDVSDHVDNDGESNLFLALRMQNILASIMLLQNGASLQEANGKGDTIVYRAALDNDEELLVLTWSFGAPLYGPTGNPILNPRGGNESQRAIVRRMALINHLKGDVHPEDMATINSQVALLSYYHYCRQVLEQMRIEERQNTGRRGIYSLLVGPRRDTVFEQAVNEQLGDLQKKLLDKNLSITFGEVQLRLLEESKSPTRIIPVRQEDIXERTPHGRTALQIAISGKHEHLVKYLIYRGEDVSDHVDNDGESNLFLALRMQNILASIMLLQNGASLQEANGKGDTIVYRAALDNDEELLVLTWSFGAPLYGPTGNPILNPRGGNESQRAIVRRMALINHLKGDVHPEDMATINSQVALLSYYHYCRQVLEQMRIEERLNTGRRGIYSLLVGPRRDTVFEQAVNEQLGDLQKKLLDKNNPYRLELKMNLSITFGEVQLRLLEERKSPTRIIPVRQEDIVRLLYKDCAIRQCVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWU6</accession>
    <name>A0A232EWU6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001819">
        <property type="protein sequence ID" value="OXU22823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWU6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7870" checksum="6C01B8667D3B9807" modified="2017-10-25" version="1">MEKANARNPRYFHDYDIIRDCIGHLVMISVVAFFFSLLFEAPVRTLECMIFRRRAVSKFSKIKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY50</accession>
    <name>A0A232EY50_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell morphogenesis protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_013010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001718">
        <property type="protein sequence ID" value="OXU23138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EY50"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="240"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="3">
        <location>
            <begin position="1341"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1445" mass="161715" checksum="6DF00844DF44633F" modified="2017-10-25" version="1">MLPETEANIENMTEGGENQPSGEGGAQGGGGETAESRVVQGEGLHEGTLETTNFSGPCQDTILTHGLGQGEGSDATSVHTASTSISGNESNSSRVSIVTVVLPWGAQKETMKSQQTGDMDLRPGEFVMQSLFADFTAQAEKKMEAVMTETEKPLSKVLQRGEDLQFDQLLSAFGSVAEHCLPSILRALFNWYERQLVDHGTDQKKLAAAKEDQKGKSIMYTIVSGSVETVEKSEADLLQERRDLAVEFIFCLMLIEILRQLPFHPGHEDLVSYIENIAFKHFKYREGIQNEPNAGNIHIIADLYAEVIGVLAQSRFMSVRKRFVVELKELRAKEPGPHTTQSIISLLMGMKFFRVKMVPIEEFEASFQFMQECAQYFLEVKDKDVKHALAGLFVEILVPVAAAVKNEVNVPCLKNFVEMLYSTTLDMCTKNKHRLALFPLVTCLLCVSQKTFFLQNWHYFLAMCLSHLKNRDPKMCRVALEALYRLLWVYMIRIKCESNSATQSRLQSIVNSLFPKGSKAVVPRDTPLNIFVKIIQFIAQERLDFAMREIVFDLLSVGRPVKIILTPERMSIGLRAFLVVADSLQQKEGEPPMPRTMGVLPSGNTMRVKKTYLNKMLTEDTAKSIGMSSYFPHVRRVFVDILRALDVHYGRPLMMTSTQNVNKEPDEMITGERKPRIDLFRTCVAAVPRLIPDGMTGAELVDMLARLTVHMDEELRGLAYQSLQTLVIDFPDWRQDVVLGFTQFLARDVQDTFPQLLDNGLRMLLQLLTCWRNALANPSAKAKEQPADGVRLNSRMIVDGVTKKDTTGQKVEPVSSVFHLVEGFALVMLCNCRLYPRRLAVHILREIKLLLKTFASLEDDQPVIDVIDACCPAVLEKYYYMLPPAEKAAAASTSNVDLQWIADRSSCVWTAGFHDENSTKSSSLLNLNGADPWSSCLFAFLEKDRVLTLCPNAVAHSWPIVFNRINSLFTVVDPTPVNDNRASLLRSSTAIRKPVNERDVYMHVWKNYLTFGYRVVPPIPSPIIRCASPDLSLSGQHTVEFGVLCMSKELSQSLENLGGAQTLPGRFSVPSISGIYTRHKRTSSSPDSLSAERGDNKSPGTNASPSALYKLTVPLLRCETIDVRDAAVHAIGKVNADALKDLMEELVPYIREAVDRKQENMRRRRRRDALRLQLVRVLELIAEYGTFGICPAVLDRETQSLHPTFVEYIDGARVYLENETDKEAPAVRDIKLHFCNFIRKMLKSFSLEACHTLLKRDLRRNLFSLFASWAGPYGKPLMFAAAMPQEGDKCSELQLSALQAMSGLLCCGPCFNTQSLSEEGSILYQWLDLLLASREEKIYGLARETVVLLLEGNPDIGPLLDWVVDRCYTGLPQVADGCFLALATIFSAREYPCDHYTSIINVTLMNTGCPRAPVQDAALQLLQLLDQRFFGNVRPLPAPDSDTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY99</accession>
    <name>A0A232EY99_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytospin-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001656">
        <property type="protein sequence ID" value="OXU23303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21199">
        <property type="entry name" value="CH_CYTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000020">
        <property type="entry name" value="Cytospin-A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF69">
        <property type="entry name" value="FI18193P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="1184"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="200"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1078"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1290" mass="146237" checksum="EB9DB80402F6237A" modified="2017-10-25" version="1" fragment="single">YYFFHTKLTHPLLFLSLQEQHSLELERLAKENEALRSRLRDVVHSPLSDSEKQQLLDASRLHNSAPASIAVLQEDSCAGTGNMTQENARSATPEWDKRSSSSEVSVACLQDRILQMEETHYSTNEELQATIQELSDLQAQLTELQADNDRLAEEKGVLLESLCRQTEKLEDSRSKVDTLQGLLLRDEQPQESKGYNTEREQKLVDLLKSAQEERESLLQKQEELTSELKSLRATADASTAEVERLTKRVQFLESTIDTANVERKLLDLELTESKQEGANRSIEISRLATLLDNARAKIEELEQSRQLETKSEADEMLDAARREKDTLETQAAALQEQLARSHCDHDRLRDQYSQLQEEFKVARNNAKSAIEDLEYRLGQLKEERVSVNAELTLVRDSLSELQSQCQRHLEDKREMKAVLSEMQRREREAQNRTYELECALAEERKLRQEESAEWQQFQTDLLMTVRVANDFKTEAQSELERVVLENKAQRDKLRALEAQLDKLNNMSDDVHKPRSTILKRGRTIIKKRFEPKKSIVKSDLPRTKGILKNQVPRIKSILKTRVNNEQGNSVWFDLSEPVDFSFKSISKDKVDPKHNISKESESSNYSIDNKRSSITSHSSKEESVPMIIDSTPKLDIDQVDAVNNSNPISTSDEILNKRSNSSSLSPKEKHVPKIIDSTLKIHNGQTDKSSVNNPSTPNSKFHVSKEETCKPINSNLKEISQNDLSEKITGIQSAGRDVYSINVSNSRFFVPNNYVYTNYENSMDDLSFKVDPEITKALRKSLEEKARSTTDISEALKKSVANENLSKYDKKFNKSTDIPNAKVEPKIVQEVGKKNFQNEDNQNKEFCSVTLRKPLQSEVVVKDIPLKDKVADSSYVSKVELRRPLKNESLTKDTTSSGIKRPLTENLQLSRSNFLRNSIHETQSTSLSFKSRNTFSRNSLEITPTAASRFPTAPKLVSTIRQKFEDLPSLRLKDENTFSRQNSVNRRRYAGNFEDAVSVKPKPLPRRLIGTTQKTMPPTSRIATTPTETQQSVINSVQNEMAARRKANITRQDSRLSVKCLIESIENATKQAKAGPGSRSSSTSSLNSIGTNDVISLKAPLRDQQINNLICTTNTTNNNNKTQTANTKKTYSETKNTVPNVLSSGQLLDTAALNAKTIDFVRRNSVTDLSDRKDPLCGLVKNGGSRRNALLKWCQNKTIGYRNIDITNFSSSWNDGLALCAILHTYLPDKIPYDSLTPTEKRRNFSLAFSAAESVGIPTTLNIGDMCQLERPDWQQVMTYVTSIYKHFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ13</accession>
    <name>A0A232EZ13_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutaredoxin-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_009229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001556">
        <property type="protein sequence ID" value="OXU23611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ13"/>
    <dbReference type="STRING" id="543379.A0A232EZ13"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="11">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12133" checksum="FBB8671B33DD6CBC" modified="2017-10-25" version="1">MGSVSSTRVLKMPITREAVDQIIASDKVVIFSKTTCPYCKMAKEVFDKLKQSYTAIELDKRDDADEIQDILGEITGARTVPRVFLNKEFIGGGTDVKKLYESGELAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ57</accession>
    <name>A0A232EZ57_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001505">
        <property type="protein sequence ID" value="OXU23766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ57"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="26" mass="3022" checksum="E1B755524E81AD24" modified="2017-10-25" version="1">MCPRERLPPLNSLAWQSRTSPLAFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZJ9</accession>
    <name>A0A232EZJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001452">
        <property type="protein sequence ID" value="OXU23926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZJ9"/>
    <dbReference type="STRING" id="543379.A0A232EZJ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="13229" checksum="6BC224E81BBFD564" modified="2017-10-25" version="1">MVHSQTLQNICKVKKTIESLVSDVLFLKKVNTAATQYGTQHETHAKKEYIKLFNCDVKKVGVIVCKNNPWLCASLDGVVVEDGCVKKVVEFKCPITCKEKPIVDYQQKKCNVNYLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0K9</accession>
    <name>A0A232F0K9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001448">
        <property type="protein sequence ID" value="OXU23948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0K9"/>
    <dbReference type="STRING" id="543379.A0A232F0K9"/>
    <dbReference type="OrthoDB" id="6692707at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16899">
        <property type="entry name" value="LYZ_C_invert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001916">
        <property type="entry name" value="Glyco_hydro_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019799">
        <property type="entry name" value="Glyco_hydro_22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11407:SF63">
        <property type="entry name" value="LYSOZYME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00062">
        <property type="entry name" value="Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00135">
        <property type="entry name" value="LYZLACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00263">
        <property type="entry name" value="LYZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00128">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51348">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759823" description="lysozyme" evidence="7">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 22 (GH22)" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="184" mass="20398" checksum="BA1D6E2CDEE8D6C8" modified="2017-10-25" version="1">MARHTTLLLLLSALSAFLLQADARILAQCDAAKELARAGIERTFISNYVCVMKSESNFDTSKKTGPGHKASYSYGIFQISSDKWCSAFRPGGVCNKNCNDFLDDDIRDDIACARTIFKLEGFKHWKGWVKSCKNGNLPNVSGCIIRRDLTEEDLVGDDSDEEEFMPVAPEITDLGETGVLDDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0L8</accession>
    <name>A0A232F0L8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_015714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001402">
        <property type="protein sequence ID" value="OXU24099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F0L8"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15291">
        <property type="entry name" value="7tmC_GABA-B-R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000056">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002456">
        <property type="entry name" value="GPCR_3_GABA_rcpt_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011991528" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="463"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1439"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1516"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1554"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="756"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1446"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1471"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1516"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1558"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1614"/>
            <end position="1623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1717" mass="193011" checksum="128DE67E89450B90" modified="2017-10-25" version="1">MAGVFALGLLLGGLGLVAANQDDNVLHIGGIFPIQGKGGWQGGQACMPAANLALEDVNREKNLLPGFTLKLHSNDSECEPGLGASVMYNLLYNPPQKLMLLAGCSTVCTTVAEAAKMWNLVVLCYGASSPALSDRNRFPTLFRTHPSATVHNPTRIKLLQKFGWSRVAILQQAEEVFISTVEDLESRCKEAGIEIVTRQSFLSDPSDAVRNLRRQDARIIVGLFYVVAARRVLCEIYQNGLYGKTYVWFFIGWYEDNWFEMNLDKEGISCTKEQMRKAAEGHLTTEALMWNQNNDTTISGMTSEDFRQRLNQVLRQTYDIDNNRYPEGYQEAPLAYDAVWSIALAFNKTMEKLNKQGKSLKNFTYNDKETADEIYSAINSTQFIGVSGYVAFSSQGDRIALTQIEQVIDGKYVKLGYYDTQMDNLTWRNMEKWIGGKVPQDRTIVKKLLRTVSLPLFITMCTISSVGIVIALALIIFNIWNRHRRVIISSHPVCNTIMLVGCIACFISVFLLGIDGRFIESSQYPRICQARSWMLSIGFTLAFGAMFSKVWRVHRLNTKTKADHAKLFIAKQKISSIQKKVQPWKLYTMVSALLAIDVVLLGAWQGVDPLQRRLEVFPLEASTQGDDDARIRPELEHCESEHNSIWLGLIYGYKGVVLVFGLFLAYETRSIKVKQINDSRYVGMSIYNVVVLCLITVPVTMVIASQQDASFVFVSLAIIFCCFLSMALIFVPKVIEVIRHPKDKAESKYNPDVGMSKEDEERYQKLLNENDELQKLIAQKEEKIQAVKAKLAERDALKGGGGGGSGGGSGGGSIPKDSLIVADFVTGEGTSDSAIGKFVYNRCSGDKKRLMGDDDPYVDVGAQFKAMKEQVNLQRRLSNDDEKSKSTIRFSPPAFIQRYEAVVNVLTDKRYGGKLKKIVDFGCSELGFAIYLKRMIGVEEALFVDIDKNTLDMFKEKTRPLHTDYLHKRSTPLVFRVMEGSVTQHDKSLEGCDAVVCIELVEHLYPEPLTELPFNIFGYIRPKVAIITTPNADFNVLFTNMAKFRHWDHKFEWTRIQFQDWANNIVTRFPEYEVTFHGICDGPPGTENLGACSQMAVFHKSYDLSVEKVTGTEGLYNPVATYDYPFEIDNRSDEQKILDDAVYYIRKFSINEDGLEEEISLKYLLRFMKKYYISPDELKQILQNAGWSVVDRENGPVVLIAPSTISDDSINDRHPDDFLDHDYPPGYYDAWNEDPGPGADYFSRNDGNDVDVVGEEEWENTPWIENETHDLKAKSEMWDTEEENSTPSIHPDDVCLDDIVTESRSSELDNSAVDDSILISSFSETKDSDNSENTKNSCVQAQASSIDIDNKIEESSTSLLPRQPIQANDSMTDFTEDSFTKHTSICSMYLEPSQISRGLYLEDLTDPLLESDLASPLPNKPNKKLKLNHNEAFNNVSENTFEDPKYTSSPHVPSSLTSEKRKISKLRTRRSNSNSSSSSNDGLLLCTNESSNDVLTENGSQQNKSSACSNESVIAESNFSSGNSPQTNYSESPEKLRHYTGTIPKSFNGKIPEMRINTQKETKLERISPDTPESPANSWSPEIMDSGYPNSNSPPDLSPEYDLSSIANDHSSDSDSPSIADAPRIGWNFDVPEVENRDLANNNLDDEGNHMEADGNQHINDLRPLINVLENDLENENDIYVVRNGFPMWLLRILQRFDAEGMGINLPMLHPPNENYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0N5</accession>
    <name>A0A232F0N5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_007772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001391">
        <property type="protein sequence ID" value="OXU24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0N5"/>
    <dbReference type="STRING" id="543379.A0A232F0N5"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="184"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="635" mass="72610" checksum="13CBA3DBC02FF67A" modified="2017-10-25" version="1">MVKKGSETKIMKFDPPIKSRYLPGEIDQDIEKVDFENYKGHRLYCANMKAVIDNKAPKFDVEIYYDREKLLADARAAKMNYKENLEITKNINTIFRMGGKVDCWNFREKRHKTDQLEKKEMYKRIMRDNRALYEKVNALSSEYSPRVMAKHWKVLKEQIESKSSANAIRPLGEQSGRRPRCFFDLELAQSNLPLGRIVIELYADYVPLICANFEAFCKGHNGLSYRGTPFHRILSGYWCQGGDVTKFNGIGGASIYEDNTLLDDISYTLQHSRPGVLSTCSDDKKTFDSKFNLTFRPLRTMDDKKIVFGRVVKGIQNLFKLEAYGTKFGKPLEKVIVSKCGILQLKRRHSSKRQSNRNSRRWLIRMINEDESSVTVWKPTKILTCPADYKFAIVVLNQPILLEHEYVLSLWKKAQVTVTVDGGTNQWMDYLGSEANNIWNGTSDNYLPNLVVGDMDSISSDLLEKLKLTKSNIIYTPDVMETDYTKSLIQLGQYTLKNNIKLNGIHVLAETSGRLDQIVSNINTLYKSHKIFNDVPVIQIAGESLTWLLKPGMHKIIIPEEIVKSKTWCALIPFGNANSCVSTTGLKWNLNKTCMQFGELVSTSNTYDGHPEVTVDTNVNLVWCMGIKPLTRVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1A7</accession>
    <name>A0A232F1A7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (34-2'-O)-methyltransferase regulator WDR6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001286">
        <property type="protein sequence ID" value="OXU24481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1A7"/>
    <dbReference type="STRING" id="543379.A0A232F1A7"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="943" mass="107341" checksum="9BBDE9ECCE632339" modified="2017-10-25" version="1">MNFSDLSTDVLAVKCISNYVFIGIGCKLYAICKTDYKIKIKIDALHPDNIHGIVVKSNSKLIVYGGKSLCVFDLNISDNDVSINILDKIHRFNDWIIDVDWLGSLRDSTLTILFAHNNVYNYDLSDQNFTNTACKEICLLYAGTISGQNYENAIIFSGTVFQEILIWSINNKRDNQYSEVLHRLKGHKGVIFSVFYNPTNNLICSTSDDRTVRLWKVSSENMDDQNPINWVNAKISLQTTMYGHLARVWRAVLFKSVIISIGEDSRICFWNLFGELIHKIEAHQGAPIWCIDISEDDIVYTGGADGYVNFWPLGSIKSYMENHILLENKDIIPKNVNFIDDGDVFIFINCDSSNKILHFCKKQYQLKHTYDVSDYSSTYCIMELSLNRQRIALASIKGEVTLYDSIQVLSKHILPPSRERWTTSACMHKNLLICGDRMGSIFIYRLDNNSKNPLQSFKKIHGRLGVQSCSIIDSNLISTGRDGTLRFYKFSNVDSITPTVNFLYTKSTPMDWASRLLKIENNYYVLGFKEEDFVIYDVRLKRILLKIHCGGGHRSWDCIIKDKLIKFVYIQKRKVCTVTIPLNKICIPPLLSGFHKKEIYCIKTLPLLSKHHNILISGGEDCSLHINYINSSTSKLKPNFKLINNFDGHLSSIKCISILSLTIYENMSKFLIFSGGGRAQLKIWEIIINFSESAFVNEDLSCKDLLSYMLHGPDKERNKIWVGKELMYNADPETRYMDISTLRNPDHTCDILIFIACSDGYLRTLNYNVESNEIKLIDTLAYKTSNKIVSIRNLPIDDKLNISLHQSGINSFDIKVVNDSEYILVTGGDDNLLSILIFEITLTSSENLFIRTKSSWKSTSSHHAQITGLKLLNDNRLVSVGADQKLLVHKYSVDGSKISSVLVEEKTLCISDVQGLTLCENQMNSTELFCIYGKGLQLLKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1M3</accession>
    <name>A0A232F1M3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001289">
        <property type="protein sequence ID" value="OXU24473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1M3"/>
    <dbReference type="STRING" id="543379.A0A232F1M3"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="272" mass="31428" checksum="A9262C4EDAE1B8B6" modified="2017-10-25" version="1">MELHPANKWPWVLRPRRNKRVTTASKDVQTMEQDSSEMSFLGLPLDVQLEILKYLGPRDLLVLRKLSKGFEKLLQNRTIWKAYEIWMNDTSTADVIEDLKRMPLLRSISIRNRVSCDLILRQISVSNKRVEHLAVIDCTGDGRINLASGYLTRILERCLKLRSFRLKGAYFCGIKFYRLLGAAVPRLREFHVDGISYNQLVAFVRQIESRTVVESADCPYSLKFETYLECARQTFRDGTFSLCNSFDFVVEKRDTLLSLYKGCVLCATLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1W5</accession>
    <name>A0A232F1W5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Intraflagellar transport protein 20 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_015671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001298">
        <property type="protein sequence ID" value="OXU24438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1W5"/>
    <dbReference type="SMR" id="A0A232F1W5"/>
    <dbReference type="STRING" id="543379.A0A232F1W5"/>
    <dbReference type="OrthoDB" id="10254896at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028172">
        <property type="entry name" value="FT20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14931">
        <property type="entry name" value="IFT20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15240" checksum="EF2890A9A62AC275" modified="2017-10-25" version="1">MADSLKKHGLFLDDLAKIRVLEPEVASQTDKLREECQNFVTRIGDFHKAAEEFIKIMSHLADRVEQEKMRAIGMRNLLHSLTKEHDAEKQQLEALVLEKQMELERLRVEYESLKKIEQEQLETIEHLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1Y3</accession>
    <name>A0A232F1Y3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013124</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001206">
        <property type="protein sequence ID" value="OXU24735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1Y3"/>
    <dbReference type="STRING" id="543379.A0A232F1Y3"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12198">
        <property type="entry name" value="MELK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14341">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000271">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="513"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="366"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="583" mass="65667" checksum="FEF0A861366F8794" modified="2017-10-25" version="1">MVRYSALKGLYELEKTVGCGGFAKVKLATHVATGEKVAIKIMEKAALGEDLPRVGLEISAMKNLLHQHICKLYQVIETEDHYFMVLEYCSGGELFDHIVEKSKLSESESRRFFRQIVSAVAYLHSLGYVHRDLKPENVLLDKDQNLKLIDFGLCAKPKGGMQSPLYTSCGSPAYAAPELILGNKYLGSEIDIWSLGVLLYALLCGFLPFDDNNIENLYKKILNGQYDEPSWMSQSSRRLIRAMLQIDPRKRITIKELCSHPWIIAGFLNPITFMKNTTVERDEEILKALKAVCTKCNDEIWKRIIENDRSDYVTATYLLLLDRKRRGLSLCLSSKLKLQFDKANKQEEPVGQTLILETPIVNLSQSPRGRKRLRNKDSDDISSPVPSKRLADEERQSTPASKSASSRDTQSTPRTGKVISEIGKHLNKVRCVLTPKRMKNETTDNSDEPITYSGKGLCNISSTSSDSPKHVLSQLRYALQCKGIVCKQKRFVLYGETEISNTSAINNKSSTKPFPLKNSCSFELEVCLIKSMTEAKPMVGIRRKRLKGDAWVYKRVCEEVLALAAQEIPKDAPDTNDPQQCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2I6</accession>
    <name>A0A232F2I6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001243">
        <property type="protein sequence ID" value="OXU24627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2I6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="113" mass="13110" checksum="D325C3493A267B52" modified="2017-10-25" version="1" fragment="single">SLTITLGEEYNTFVSYGNLNPNVDPSNQFVKSAMNWLPIDWKKKISNNYCEFHEVNGMCTRIYDATVTSDLKLFAESRKKARNAITRPHLINIAVKSRYWYNTTSSKNVRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2P9</accession>
    <name>A0A232F2P9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_016417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001176">
        <property type="protein sequence ID" value="OXU24862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2P9"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="194"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="663"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="891"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="579"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1362"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU24862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1383" mass="159602" checksum="C99799C6D7D1ACC7" modified="2017-10-25" version="1">MHLLRYTGLYGFIRRRETVRRCIVGMLGSSRMIIIHIPVLDDCAGEILFTVISLLMIDRLVFVNNFADDVAACMSALSSTRPGLVYSSEVLSETLLQLDRSCGRLMWCIKMSAPEGDSASHKQHRERNAGRKADKKKIKKKDPSHIIEDPKQKNPKAFTFNSAIKAERNFRRKQDIDTKKQHIPVVDRTPLEPPPILVAVVGPPKVGKSLVIQCLIKSYTKNPLTSITGPVTLVSGKRRRITFIECNNDINSMIDIAKVADLVLLLIDASFGFEMEIFEFLNICQVHGMPKIMGVLTHLDQIKNAKQMRKTKKLLKHRFWTEVYSGAKLFYLSGLLHDEYLRMEVKNLARFISVMKFRPLTWRTTHPYLLVDRVEDLTDPELIRQNSKVDRTVSVYGYVRGVPLNKQSSIHIPGCGDLKIKDISFLPDPCPLPEQLKKRALVERERLIYAPFSGVGGIVYDKDAVYVELGGSHSHTKDDTGLLSQLLQTHETLDHKLEQSELQLFTNSAPIKSQDVNQIFTEENVFDQGRIRRKVVFNDSEKDKNEDEEDDESDEEMDLEGELNELTAQKTKASKDKTEEEEGEDDDDDDGDEEDDEDEEMEDGSDDEDGQSKDEIGKSRKRKAVEKSAKKKMKLDPDSKNPELYRELRINQDKHVKDKISEALGLIGDTNLKAFNSMEKGTKDKTRGDDGNDESFDELSEDEDMDFELKLDNDDDDDDDDDIKGNKDDNNKDDGENEEDDDKDDENESEEDEDDQENLKWKENIAEKAREAFLSRQQTNINVMRLVYGVFDGDRNYQEDKQEEPEKEEVGGIFHVVQAKQKQKIEERELKNQEESVFFSKELPRDWLAEDNKCLLVNRFVTGKWKESEDAEELLKLDDLKDDDEEVYGDFEDLETGEKHKASEKQPTTSEPTPKVPKEMTSDELDERKRLLEKKRKLKEQFDADYDTTDKTYYEDLKLEVERQAELNKSEFEGLDDNVRVTLEGYRPGMYVRLEIDNVPCELIVNLDPTYPMIVGGLLPGEENIGYVQTRVKKHRWYSRILKSKDPLILSVGWRRFQTMAIFSKLEDNLRNRMLKYTPEHVACMAHFWGPITPQNTGVLAVQDVSKREPGFRIAATGTIVELDKSTKVVKKLKLTGVPYKIYKKTAFIKDMFTSALEVAKFEGAKIKTVSGIRGQIKKAVSRPEGCFRATFEDKIQLSDIVFCRTWYRVDVPKFYNPVTSLLLPPEQKSQWKGMKTTGQLKRELNLKATPNTDNLYTPVLREPKVFKPLVVPRTLQKDLPYRDKPKLQPVLGKRKTKFEEKRVAVVREPREENVARMMKMIRTNYSYKQEKLKEATHKRITEYQKRVDEETAKKMKRQREMKKQVFRDLSKLEAKANKKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2S3</accession>
    <name>A0A232F2S3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thymosin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001103">
        <property type="protein sequence ID" value="OXU25126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2S3"/>
    <dbReference type="STRING" id="543379.A0A232F2S3"/>
    <dbReference type="OrthoDB" id="2151618at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.520:FF:000001">
        <property type="entry name" value="Thymosin beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14406" checksum="3B54943503B90A28" modified="2017-10-25" version="1">MSDPVSPSLKNLPKVAVDLKSELEGFKTSCMKKAETAEKNVLPSAKDVADEKTQQTLIAGIEHFDTSRLKHTETQEKNPLPDKDAILQEKGKQQLISGIENFDPAKLKHAETLEKNPLPTKEAIDAEKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2S7</accession>
    <name>A0A232F2S7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001203">
        <property type="protein sequence ID" value="OXU24753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2S7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="11266" checksum="DFF8BEEA176ABBFF" modified="2017-10-25" version="1">MCKPPYTWCTDLRHVHNKELRTKEGQGAPHLTTKYLETIASLDERRCFVYYRGACQIRRYATCKPLHWSNYPLIVTSIRQRGAVRKLEALDKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4Q4</accession>
    <name>A0A232F4Q4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc finger protein ZPR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_007742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001054">
        <property type="protein sequence ID" value="OXU25327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4Q4"/>
    <dbReference type="STRING" id="543379.A0A232F4Q4"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000003">
        <property type="entry name" value="zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="7">
        <location>
            <begin position="249"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="443" mass="49865" checksum="96192D6B225775C5" modified="2017-10-25" version="1">MAEDKHTEIKKSQPIFRELNADDPEPEATVIESLCMNCGKNGVTRIFLTKIPFYKDVMIMSFECEDCGYQNNEIQNAGKIEDKGVKIVLQMKSKSDINRQVVKSDYTSVSIPHLEFEIPSQSQKGEVTTIEGIINRSITGLEQDQNRRRKENPEAAEQIDQFINKLKALKEVAEPYTIIFEDISGNTNVQNPKAPQKDDGCEVHYFKRTTQQNHTLGIYIENEETILQPINEEEYTLEEIEGEVMTFPTNCPECNSPCQTNMKMTKIPYFKEVVIMATVCDTCGHKTNEVKSGSGIEPHGVKIEVKVTGKEDFSRDLLKSETCHMNIPELDLEVGPTTLGGRFSTVEGIISAMKDQLSTSTALTGDSADPEIAKRMDNFISQLDEILQGKKQVTLVLDDPAGNSYIQSLADNGTDDRLKITKYTRTFEQNDELGINDMKVENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F526</accession>
    <name>A0A232F526_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000992">
        <property type="protein sequence ID" value="OXU25580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F526"/>
    <dbReference type="STRING" id="543379.A0A232F526"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="436" mass="50165" checksum="E5781425B2BF3E39" modified="2017-10-25" version="1">MKNEKMNEDLAPIPFRILKFCGWWRPLNLSTWSRAVYSCFTVVMLTLLVTITLTVLIGVTQMSATDDLFADNVFLMFALINSVFKATNVLLSRRRFIKMLEIVQDTRWRDLRNDEEIEIQDRYRKTIRKISVYFTTAVFIAIVLRVVAPLLDLSDEIKLPVDAYCPCDIRHSSCYWTLYWHQAFGTGVATLTHAAKDCLISALLLQTCAQLEILKNRLLSIADTCVVAGNKTGAADRVEKLEQKLIGECVRDHESIFEFAKILNDSLNVMLFGQIAVTIPNLCLSIYLLSTQKIASMDFMMTTQFFSAVVIELFFFCWYGNEVTLNSLDVENAISEMNWTLLSTRSKKDLLMMMVRTSRPILFRVGPIMNMNIDSFLSVSLNMRTFSTNLGEFVSYMIVLSDHENILFCLQRFAVYWRLANVYKMIIKDKVLVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F654</accession>
    <name>A0A232F654_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Neutral ceramidase</fullName>
            <ecNumber evidence="2 7">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="2 7"/>
    <dbReference type="EMBL" id="NNAY01000885">
        <property type="protein sequence ID" value="OXU26062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F654"/>
    <dbReference type="STRING" id="543379.A0A232F654"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="9">
        <location>
            <begin position="547"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="713" mass="78883" checksum="332E6DA2FC20B48B" modified="2017-10-25" version="1">MDSLRNRLRPRKCGLIMTFLLIGILVPNVVSSYSIGVGISDTTGPVAEIVFMGYAKMDQKGSGLHLRTFARSFIIDDGQHRFVFVTVDSAMVGHDVKAAVLRNLQSHYGDLYTESNVMISATHTHSAPGGFMMDVLFDISTYGFVKESFTALVNGITKSIDKAHNAVVPGRIFITRGEVLEANINRSPLAYLNNPEEERNKYKYDVDKDLVQLQFIAANGKPLGVINWFAVHPTSMNNTNHLVSSDNVGFASVLFEKRINKNAMVGKGDFVAAFASTNLGDVSPNTRGPKCEFSGQHCTAQYTCPGKKEMCFASGPGKDMFESTSIIANKILDEAWKLWGSGSVTEVKGPVRIVHRFVDMPKQSATFYNATTQKVEEVHGCLPAMGYSFAAGTTDGPGSFAFEQGTTTSNPFWNTVRNFLAKPTDQDVRCHGAKPILLATGRMKLPYQWQPKIVSTHLALIGNVAIAGVPGEFTTMSGRRLRDTVKTAIVEADKSFENANVILAGLCNTYSDYVATPEEYQIQRYEGASTIFGPHTLTIYLKQYAELAKHAVLDETVEPGPNPPDLSKEKLISLVPPVIYDAPKWGREFGDCVKQPMRTARPGDVVTARFISGHPRNNFMTGSTYLTVERLEEDETWTPVATDADWETKFIWERTSSILGSSQVITSWEVPENVIPGEYRIRHNGYYRYILGGVYPYQGVTNHFQVKTPNLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6X2</accession>
    <name>A0A232F6X2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ras-related protein Rab-43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004406</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Lipid-anchor</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000847">
        <property type="protein sequence ID" value="OXU26220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6X2"/>
    <dbReference type="STRING" id="543379.A0A232F6X2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000803">
        <property type="entry name" value="Ras-related protein Rab-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="224" mass="25690" checksum="4347A14A5F80BFD3" modified="2017-10-25" version="1">MSSRDPNNLMTTTSNDEGFDYLFKIVLIGDCGTGKTCIVQKFRSGNFIQRHGNTIGVDFSMKTVLVDGKRVKLQIWDTAGQERFRTITQSYYRSANGVILVYDMTKRSSFLSLQRWIDEIRRYTSSHLFLCFLYNPGNKCDLEDAREVQKAEAEAVCEYLPEVFRIVETSAKENTNIDSIFFCLASELKRRHENRQVNTEENDTVKLGNGRNLSSCSTCSFKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F737</accession>
    <name>A0A232F737_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox protein engrailed-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_003301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Engrailed homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000807">
        <property type="protein sequence ID" value="OXU26412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F737"/>
    <dbReference type="STRING" id="543379.A0A232F737"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000345">
        <property type="entry name" value="Homeobox protein engrailed-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000747">
        <property type="entry name" value="HD_engrailed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019549">
        <property type="entry name" value="Homeobox-engrailed_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019737">
        <property type="entry name" value="Homeobox-engrailed_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10525">
        <property type="entry name" value="Engrail_1_C_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00026">
        <property type="entry name" value="ENGRAILED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00033">
        <property type="entry name" value="ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU510713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="132" mass="15169" checksum="F2561D162C970D9E" modified="2017-10-25" version="1">MPFGERTLKVRNSVPGPRTRRPKRTADRPPAATPEEKRPRTAFSAEQLARLRDEFTENKYLTEQRRQTLSKELGLNEAQIKIWFQNKRAKIKKASGQKNPLALQLMAQGLYNHSTVPLSKEEMEQAAELQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7T6</accession>
    <name>A0A232F7T6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fascin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fascin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000754">
        <property type="protein sequence ID" value="OXU26662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7T6"/>
    <dbReference type="SMR" id="A0A232F7T6"/>
    <dbReference type="STRING" id="543379.A0A232F7T6"/>
    <dbReference type="OrthoDB" id="10259868at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23351">
        <property type="entry name" value="beta-trefoil_singed_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000008">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000010">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000015">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000064">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010431">
        <property type="entry name" value="Fascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024703">
        <property type="entry name" value="Fascin_metazoans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551">
        <property type="entry name" value="FASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551:SF9">
        <property type="entry name" value="FASCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06268">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005682">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="147"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="285"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="426"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="517" mass="57614" checksum="C6F58C1ADE7E909E" modified="2017-10-25" version="1">MQSNGTEHSENGVDKTGWTIGLINGKFKYLTAETFGFKINANGASLKKKQLWTLEGNEHQVYLRSHLDRYLAVDQFGNVTCEAEDPSDPGCAFQIQLACDGSGRWALKNVQRGYFLGSSQDELKCTAKAPGESEYWLVHLAARPQVNLRSAGRKRFAHLSASQDEIHVDAPVPWGEDTLFTLEFRGPSEHVDARGKPEGGHYALHTCNNKYLARDGKLLETCTRDCLYAAEFHAGLLALRDISGGYLAPIGSKAVLKSRSTTVTRDELFSLEDSLPQASFVAALNQRYVSVKQGVDVTANQDEISGHETFQLEFDRTTKRWYVRTMQDRYWSLESGGGIQASEHKRSSNGLFDLLWQPEDGTVALRANNGKYLATKRSGHLYANADNVNVENDACKYYFYLMNRPVLVLRCEQGFVGPKSAASPKLECNKAGYETIRVERCERGVVRFKGQNGKYWHADSEGVTVDSDVPACGFYLELREPSRLCIKATDGRYLSAGKNGALRLGETDYASATKWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Y9</accession>
    <name>A0A232F7Y9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Timeless C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000746">
        <property type="protein sequence ID" value="OXU26712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Y9"/>
    <dbReference type="STRING" id="543379.A0A232F7Y9"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26019">
        <property type="entry name" value="HTH_TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012036924" description="Timeless C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Timeless C-terminal" evidence="4">
        <location>
            <begin position="393"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="757" mass="86944" checksum="95AA0E51876CB3C5" modified="2017-10-25" version="1">MSRGRLFLIIIELAYFFSVPDDVPGTQGSGNQVEGLLNYEDEEDDDEENEEEEEETRFEETSFKFMDFLQRFANLRVVSNLAILLKNFEKNTPELNHYVLKMFHRIALDCKMPAMMYQASIFRVFQRVFQSDSRVHKELASFARFVFRGFAEVASRNPKAYMELLFWKSTKQATEMVDGYDAEPHAKKSKSAWSEEEEDELRTLFMEHQTNKPSQDVVDYILSNLISQDRTRRGVMKKLKEMYLIVNSKSVRSEVSKRLPKEWSEEEVAQLTELWEQVREEDDPVGLIYDSLRIKRSKPKIKEKLLELNLAEDAKQLRKKRTKKSSGPKSSWENASASEDEDGSGSDEDEDDDGGVSGSDAGKKKKKKEKSRKERKKSKQPAIVYTDAQLSGLLKDVIANNLQEALQWLKESLEESLEDRDEESHEGLALVPLTAETSAAMDSPNFQRFLRGVGIEPPDLEEAYWRIPASMLVTTVKKRIEIIDKALKGEFVEEVVVASRRRDESESDEDDDDFFERLKKYSKRNDDDAESAPLTSQKSASSKSAVRKVHENPESPKSDKENHGTENEILLNGNAKRSDSEKEEDKTSPTTKSPDEERKSKPKRIKTVLDLSDSEDERQPSQEENNDDAIRTDSSQDKTNKSKRVLESDSEEERMETESQSQTDVRSKIEPKEGSAKSSRIRKVLDSDSEEEAEKLPQDADESSLEAKRTRSENSDSETPMQKKRRVLDSDEEDDFVKKAEKPVEKKQSRVLSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8A7</accession>
    <name>A0A232F8A7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_012581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000752">
        <property type="protein sequence ID" value="OXU26683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8A7"/>
    <dbReference type="STRING" id="543379.A0A232F8A7"/>
    <dbReference type="OrthoDB" id="10054259at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF25">
        <property type="entry name" value="TEKTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="415" mass="48924" checksum="C80DA38803002863" modified="2017-10-25" version="1">MINSLKINQPIEQHNTSRQNPKFTIKDWYYNNHLRNHSSEIHQELARQIIAKSNQVCQFTTEKVISNRDQTNHCLNERINEIEFCKQELIRNRNELPLEIDALISYKNRLLDSLSSLRQNALDICEKCLSARERRLGIDLVNDNVEKQLRQECKGIKCADQLMTKTLEQTIEQIRRLKSTLYHIDHDLEHKENNLRIDRHNSTLKETNLNLSIHHGKSTLDASSITLEEWEMKTKKNIDESTKEIQTAKKIRSHIDLVLKQIINDLMNKKNLTNEAFRQRIKETKEAKEKLELQHSEIMRQANEMTRNITSLQKKIAEKEGFIALAHTRLGNRCQRPGLELTCDHVEKSLSKEIFDLREVVTRLQQTLFEAQALLRFLLKMQIQLEEDINIKTNTLKIDEVECMTMRQSIDYHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8B8</accession>
    <name>A0A232F8B8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transcription initiation factor TFIID 18 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_008389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TBP, and more strongly with TAF10 and TAF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000669">
        <property type="protein sequence ID" value="OXU27084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8B8"/>
    <dbReference type="SMR" id="A0A232F8B8"/>
    <dbReference type="STRING" id="543379.A0A232F8B8"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000028">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="127" mass="14769" checksum="934C6F791006CB12" modified="2017-10-25" version="1">MAQEETFEQFEDEESEIPIGGSLTSGRKRLFSKELRCMMYGFGDDQNPYTESVDLLEDLVIEYITEMTHRAMEIGRTGRVQVEDIVFLVRKDARKYARVKDLLTMNEELKKARKAFDEVKYAGNVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8U0</accession>
    <name>A0A232F8U0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000741">
        <property type="protein sequence ID" value="OXU26737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8U0"/>
    <dbReference type="STRING" id="543379.A0A232F8U0"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039508">
        <property type="entry name" value="KASH5_EF-hand-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14658">
        <property type="entry name" value="EF-hand_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="148" mass="16449" checksum="550B7BBF319DBE5D" modified="2017-10-25" version="1">MRKAFQMFDTTKSGFIDTIKISTILNTMGQLFDDAELNAIIEENDPEGLGKVNFDGFCRIAGRFLEEEDSEAMQEELKEAFRLYDREGNGYITTATLKEILAALDDKLTNTDLDGIIAEIDTDGSGTVDFDGSFSSLLVFFFVCEPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F904</accession>
    <name>A0A232F904_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_013829</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000694">
        <property type="protein sequence ID" value="OXU26939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F904"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="102"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="420"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="703"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU26939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1313" mass="147577" checksum="23BC50F8BA849E55" modified="2017-10-25" version="1">MDEGEQKREENPRQGASRLSVITFAWLFKTFRTGFRRELDLSDLYYPLNEHSSHNVGKRISAEWKREQARCKDLNKGLSPNLMRVLFTCFGKEIMLAGLVQAMLEFFIRLSRPYILLQLLHYSSERSDMAKIEAYGWAAALVAGVFIDCVVCHLCVQSLMHTGMKIRVACSSLLYRKILSVPITFTENETSVGQVLNLLSNDVSRLDHAVFYLHYIWMAPLQAILVFYFLYREVDLAAGSGILLQLLFIPILGLFGRLTNRLSSKYATRTDERLRLTNEIIKGIKAIKMYAWEKPFSALVDRARKKEVQIVKQDSIMTDMSLASEFYIPRLCIFITVLSYVLLGSSVNAEKVYVVTALYDVLRMSMYTLFPMCLHDAVEALVSVRRIQKFMLIEEIPCLPTTTSNHVNNAEPIIPKDPAIHLKNLGAQWTSKVKVLKNISLQIHPMTLTAVVGQVGSGKTSLLHAILGELPHVSGESLTRGRVSYASQEAWIFASTVRQNILFGRPLDEARYARVIDVCQLRRDLDIFPHGDATIVGEKGINLSGGQCARLNLARAIYRDTDIYLLDDPLSAVDAAVGRKIFQDCIKTQLKDKTVVLVTHQFQYLEEVDRVLVLKDGTIEADGTLAELQNAGVNLVKVMQVSNEFDEVKLPQEPATELASSENLSDGLEEKSDKLTEKKIGGSITLRTYVSYFLASRNMPLVVLVVFTSFLHQLAASGGDYFLAYWVNAEENATTHKNESCPEHVCDARDWYIYLYGGITTATIVMCLLQSWTFFEMSMRIANNLHAKMFVSVICATMEFFSTNPLGRIMNRFSKDMSIVDTEVSRAMIDVIQNAIHIFAAFVVVTTVNPWLIIPAIFVGFVFYFFSLFFIKTSRSIKRLEAITRSPVFGHVSDSLQGLTTIRALRAREILIDEFDDHQDLHSSAWFIFFSGSRGLGMYLDLFCAFFLTCVILTLMSVDKTTLAGDIGLAITQCMLLINTLQWGVRQFAELENQMTSVERVLEYSKLPSEPYDRSSAERRLEEVTEASPLTDAKLEIQTPMNAVAAVGAWPDNGRIEFRNVYLRYDKQGPPVLRGLNFSIEPREKIGIVGRTGAGKSSLINSLFRLAYLEGEILIDGVSTSQLGLHELRSHISIIPQEPILFTGSLRKNLDPFGEFSDNDLWQTLDDIGVKSSLDPNTGLNTRVAEAGSNFSVGQRQLLCLARALARKNRILVLDEATANVDPCTDELIQRAVKRKFEDCTVLTIAHRLHTVIDSDRILVMDSGTIAEFDHPYILLTEKKGLLYDIVQQSGSGAAQLLLQIAKLSYDKKTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9D8</accession>
    <name>A0A232F9D8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000672">
        <property type="protein sequence ID" value="OXU27068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9D8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="143" mass="15731" checksum="BFC5E76085D97BB9" modified="2017-10-25" version="1">MLTSISNSFCHWLTIEAASRESIATAISAISAISAISAGVSTVADGASSITAVSKATGTVAETSCVTWLWLWVGADECHQDNGEYEEFEEHAARVTFWKYMKLIQEQLRNSVVPVFQTTLHKKPMADFFQAEHKGKALTMMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9P3</accession>
    <name>A0A232F9P3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000649">
        <property type="protein sequence ID" value="OXU27190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9P3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="9220" checksum="D263612396ACA906" modified="2017-10-25" version="1" fragment="single">KKTAQITRNCNNYKYNISDNESNAATQGVCLVFILFYDNYIGHHKINFSETYIKNDETATRTTIFLVLGNTICVCRKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA78</accession>
    <name>A0A232FA78_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000580">
        <property type="protein sequence ID" value="OXU27565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA78"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="31" mass="3433" checksum="9E87C7D85AE27C41" modified="2017-10-25" version="1">MRCVIDALLASSAEMILPARADSRSQRPMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAJ9</accession>
    <name>A0A232FAJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000591">
        <property type="protein sequence ID" value="OXU27510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAJ9"/>
    <dbReference type="STRING" id="543379.A0A232FAJ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393966" description="Peptidase M12B domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="426"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU27510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1038" mass="117135" checksum="2E3BBB8C682F68DD" modified="2017-10-25" version="1">MLLSIVLAVCLISSIHGEKLHEHMTNDEILSVFNVHHDAVKGLDYQLVNIIHLDPRNVSEGRRVRTRMSQPNLHLKAFSQNYTLYLEENDNVLLGSSTPVFIANASPRKRSPFSDDSNNIVYSRIQYPLPASFKMYHDVENRAAVTLEHEDDKFHVNGIVGDDIVIRSLPKRVHDEVLSKYSTRSKRSSIFDDDSFYFDNPFADPNSVFKDTYKTTHHVIIKPNVNDNRPVFGSLDTAWNEIKNNYFKNNEDDSFGGYVPWKNLHKTYNFSGPIYNRHNDPSTRFVSWQGSYKPYNSSGSTYVSHVTWRPMYEPFNWRQTTKAPFTWRPTTRLPFTWWRQPTIPTVTWYQPSINDPASWIFPTTKKPFADYTLPTRKPTPDSRLPIYTRLPPRIPATKKPVTSTTQNRISVIPAPAGPGTKRSDTVYPQLLIAVDYDTFKAHGSDVEEVSKYMAAFWNAVDLRYRELNSPNVRLNIAGLIIPKQPNSASYMEEHKVGAESALADETLITIGKYFAKNLKEFPKDMYDIVIGMTTSDLGSVNKTGKFEGGTTGIAFFKGACKLEYGIASGLVRDKGGFNGITTAAHEVAHALGAPHDGKESADVKGGPCSWEEGYLMSYNRKDKKGMHFSKCSVQAMQDYFSNPEAKCLKNKPNTGSPYPKLLPGKVLSRDEQCRRTMGNTWTSYVGYESNCATLWCKETDTTNIITHYRPPAEGTYCGEGASELVPIFHFRKSTGKAHKTLHIPTTTQNYTLYLKGNNYLVGTATPVYKAQPDPTLQLYHDVANEAALAVHTDHKNRQYIDGIIGEKLIRSLPSRIHDFVLAEYKNVLASSYEDDVYQSFVNESTDDPTIDRPVFYVAIDSIIGKVNTSTFEFYSDDSDDKVGDSSLSYDRSTVDLRFRELKNPKVRLNTAGLIIPESNKTFPYDTYDFIAFMSKAMYGIDLDEGGFQTGMNEGANIDGACGHLRPNEKVNVTAVINDVGFSELAHLFGTPHDDRTSASIPGGPCSWYGGYLMTYQRLDIRGIKWSKCSKKAMEIFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB38</accession>
    <name>A0A232FB38_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000584">
        <property type="protein sequence ID" value="OXU27547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB38"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19303" checksum="9466BE0D01A42DC8" modified="2017-10-25" version="1">MCSLKKLVRKGEKPLQQITRRLTEYESIVDIRQQENVQKIEFCASKTHYNGNLAGNRKYCSQYKILSNNIININVADTRNNCVMLKDNTIVNVVNIAKSNGSLYLIGRRCVKQKGLFTLGKFHSGTVSVNLVIESTFLEDWKCNMNRAKVFKISCSTVFITYPLSHTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB43</accession>
    <name>A0A232FB43_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Laminin EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_006836</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000483">
        <property type="protein sequence ID" value="OXU28064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB43"/>
    <dbReference type="STRING" id="543379.A0A232FB43"/>
    <dbReference type="OrthoDB" id="8545473at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000069">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000082">
        <property type="entry name" value="Laminin subunit alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000033">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF428">
        <property type="entry name" value="LAMININ SUBUNIT ALPHA-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="13">
        <location>
            <begin position="196"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="427"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="539"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="584"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="12">
        <location>
            <begin position="631"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU28064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75658" checksum="505EEF5BEB2B1230" modified="2017-10-25" version="1">MCDRCCPMYNQVPWQPGTSGKGFHCEKCNCNGHATACRYDHEVAEMKLSMDVRGKYRGGGVCLNCSDYTTGINCEKCEAGYYRPNGIPPDDPEPCVPCDCHPRGSTGLCIPDDSFTSLGKFPDCLPCPCDARGILPSHDCEGDCLCKAHVTGEYCDQCKPGYFALARDHIEGCLPCFCSGQSDECAVAKISLSMVSTLAGWQVSDINGSRAVSPSLQGEHGWPTIAAFEVEYRSPYWLAPKIYAGNHLSSYGSNLTFLVSWIVMRGDTSGKPTSEPDVVLIGKNGMRIAYGEDSHMGQQAEITVPMLEHGWFHVQVSPEIIDGVTRFRRTDYRGDPVTRQQMLEILADVEHLLFRAQFHTEQIEGSLKSAILPVGEVSMDDGENSVVEMCSCPVGYTGLSCEQCDWGYVKVPINSTDHHVRHKCVKCDCNGHAGSCDLMMPECSTCEHHTIGPKCDRCAVGYFGDATRGTPEDCHRCACPLDIPTNNFSPSCQLDDPYDSEGDYVCTQCPLGYTGDHCETCDIGFFGDPLTPGRTCEPCPCFGGPCDQDTGRCLECRGNTEGWKCEKCKEAHYGNPAELNCLPCACDPLGSTSMLCESRTGQCTCRPLFDGRDCSICIEGYGNVTAGCIECDCGIGAEDVQCDPVSGLCSCSPGAVGPRCDHCDIDHYGLSFDGCSGKSLLLNYENFFICLERGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBC7</accession>
    <name>A0A232FBC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000566">
        <property type="protein sequence ID" value="OXU27637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBC7"/>
    <dbReference type="STRING" id="543379.A0A232FBC7"/>
    <dbReference type="OrthoDB" id="7698356at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="94"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="211" mass="24551" checksum="A61109DDE8221033" modified="2017-10-25" version="1">MLSLHGSRSGQHTPNKLRLSKPNRVRAGKSLLFLAPLPLQLPGVFTRGRGKEILTLSVLKWPHIPRGLRVILHDALERLSIDLYSRFDPRPYVRNTFNQIPIAPEDIEKTAITTPFGLFEFLFMPFGLRTASQTFQLYINRALGDLDFVYIYIDDILIASDSLEQHHKHLRAVFERLKKFHLRLNVDQRVFMVEELEFFRYLINTQGIKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBI8</accession>
    <name>A0A232FBI8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_006577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000463">
        <property type="protein sequence ID" value="OXU28191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBI8"/>
    <dbReference type="STRING" id="543379.A0A232FBI8"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="457"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="923" mass="101379" checksum="F66FEEC8BE271EA1" modified="2017-10-25" version="1">MGPEVLKKSKQASDIKSHVQWIATFGVFLLMFQVGINIGWASPNLARFASEDSPIQMTTDEISWVLACTGIGGFFGSILFSIGLEFFGGRKIVLVIFITISLSWIFLIVANSVVWIYIARILGGITCAGSYASFSIYLGEVVQSGIRGTVVAVATGGNALGILVGIVTETYITSMKVSCPIYLVFCVISILLFIWLKDSPYYCAKKGDFKSARKSIAFYFPGCDVEEELKPIQAFVEANANNTFKGKLKQLKEPVVRKSLLIIFIIFGLPHVSGQVNIMSYMEIILRNGKSDLIKPQEFVIYANIISIIATLVSIRFSDRFGRKAALIFSSIGCAIGMVCLGIHFFLLTENVDAQSLQWLPIFSIVFYLITYAVGYSPVPSTVLSELFPESIKSIAACFAALGASFFGTIVTKSFQPVVDTFGDAYIFWLHAALSLVTIPCALLLLPETKVNVESCKKWIPTFGAFMLLIQLGINLGWPSPNLVKLTAPNSTIPVTASEASWVISSARLGGFAGAIVALICVAFVGSKKTILLTLAIISTSWACVIIANSVDWLYTSRFLSGLTQSTTFSSFPLYLGEVSPPKIRGALMCLAMVGAPVGIFFGTIAESYLSMKISSSIYLALCWIAMIIFIWLPDSPYHLVKTGDHKRARKSINWYFSNCDVDKELDEIRNFVEANIGQSMKVQLYELNSPHIRKSLFVLLTLYILSELCGAVNLLAYMETILIHAKCNFVSPKVFVIFASSSGIFTIGLTMKLIDKCGRRFLMMISSIGTSLGMVGLATHFCLLNANVDPVVIQWLPFISIMLFLMTFAVGYSCIPHTVLSELFPDNAKNVAAFLATLTSSIFGFVITKAYQPMVDFMGEAFVFWIHAGFSIMAVPCIVFLMPETKGKTLLEIQNLLVKKKDALSVETNIPYLNKVEMITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD20</accession>
    <name>A0A232FD20_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000414">
        <property type="protein sequence ID" value="OXU28575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD20"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9016" checksum="EFA4CC2699D2F581" modified="2017-10-25" version="1">MTDSSYTDSAVVRPFRTVFRFVGALFDAVYYFVESLINPSAGRYSRGRLTGSGRPSGPRIGTLRPSGSGGNAPNMSIGGCRSCAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDF1</accession>
    <name>A0A232FDF1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dopamine beta-hydroxylase</fullName>
            <ecNumber evidence="7">1.14.17.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSAR_012952</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Alberta</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O</text>
            <dbReference type="Rhea" id="RHEA:19117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:72587"/>
            <dbReference type="EC" id="1.14.17.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19118"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer; composed of two disulfide-linked dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Chromaffin granule lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Chromaffin granule membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.1" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000390">
        <property type="protein sequence ID" value="OXU28715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDF1"/>
    <dbReference type="STRING" id="543379.A0A232FDF1"/>
    <dbReference type="OrthoDB" id="129121at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.310:FF:000003">
        <property type="entry name" value="Dopamine beta-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020611">
        <property type="entry name" value="Cu2_ascorb_mOase_CS-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF29">
        <property type="entry name" value="DOPAMINE BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00084">
        <property type="entry name" value="CU2_MONOOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0186">Copper</keyword>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013031393" description="Dopamine beta-hydroxylase" evidence="23">
        <location>
            <begin position="20"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="24">
        <location>
            <begin position="37"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OXU28715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="604" mass="68128" checksum="74DC3710A394F00A" modified="2017-10-25" version="1">MKFSVVLVLVSHILIAVSGRWHQSESTLAVHSVPLGSEASFHWRVELTTEQIVAEVHYAAEEYSWFAVGFSNYGELKQADYCVLWVDWHRETHLEDASSDVDSKLNTDEQQDCTNFEWKKHGNVTKFTFTRKFDTCDERDYVIEVDNRTISQFLLTLITVYYLIASVQRGTTHLVWLKGSGPLTSVAGLQVADAKSSGMSRTELLRIHHPKPQFPADAWQHEIRADRVQVPNVETTYWCHVQKLPSSMRRKHHVLQFGPAIQQGNEHLVHHMEVFHCAGPADVDVPLYNGPCDAPNRPERTQICKKVLAAWAMGADAFVYPEEAGLPIGGENFNRFVMLEVHYNNPELLAGNVDSSGIRFIFTKSLRKYDAGVIELGLEYTDKMAIPPGQEAFLLSGHCISECTGVGLPQSGIKIFGSQLHTHLTGRRVVTRHIRDGEELPMLNYDNHYSTHFQEIRLLPQPVTVLPGDSLITTCTYETLDRENVTLGGFAISDEMCVNYIHYYPNSKLEVCKSAISDDALRTYFRYMKEWESQRTSGDKGISDNYKSIEWTKVRVAALHDLYEVAPLGMQCNGSDGSRLPGLWDNIASTPVRLPLAPMARGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDK4</accession>
    <name>A0A232FDK4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000414">
        <property type="protein sequence ID" value="OXU28573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDK4"/>
    <dbReference type="STRING" id="543379.A0A232FDK4"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14477">
        <property type="entry name" value="SPX_XPR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF127">
        <property type="entry name" value="LD30826P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="9">
        <location>
            <begin position="422"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="630"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="77001" checksum="F207150314BCAEA1" modified="2017-10-25" version="1">MKFAEHLSAHITPEWRKQYISYEEMKAMLYTAVEEAPSAESVEPEVITRHFASFDEVFFTFCDRELKKINTFYSEKMAEATRKYAALQSELKTAQDLQHGGGKNKGKAFKSQLPTRKMRELKLAFSEFYLSLILLQNYQNLNYTGFRKILKKHDKATLGLLSVDTGSKWRVECVETSHFYTSKDIDKLIQDTEATVTNGLEGGDRQRAMKRLRVPPLGEHQSPWTTFKVGLFSGSFIVLFVAVVLSAIFHDNGDNLKIAFRLYRGPLLIIQFLFLIGVNVYGWRSSGVNHVLIFELDPRNHLSEQHLMELAAVLGVVWTLSLLSFLYSASLSIPPYVNPLALVIIMTAFLLNPLKVFRHEARFWLLRIVWRVLIAPFAYVNFADFWLADQLNSLATALLDFQFLTCFYITNGNWLEASDTRQCTSGSLIIRPLVNCLPAWFRFAQCIRRYRDSKEAFPHLVNAGKYSTTFLVVITSTLRIYHADKYQGTWESPWLWLWLVSCFINSIYSYTWDIKMDWGLLDGNAGENRFLREEVSFYYFAIIEDFLLRFVWILSFVLVEYGFIGNDLMTSIVAPLEVFRRFVWNFFRLENEHLNNCGKFRAVRDISIAPLESSDQIQILRMMDEENGVLNRGKRKGGGKKQSGSKEEKRMLLKDETVDIDMSNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FED9</accession>
    <name>A0A232FED9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000362">
        <property type="protein sequence ID" value="OXU28880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FED9"/>
    <dbReference type="STRING" id="543379.A0A232FED9"/>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013053835" description="Peptidase M12B domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="232"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="456" mass="52382" checksum="9B4B6C027C23DB77" modified="2017-10-25" version="1">MMAYRVAFLSLCFFSVSTALLKTNEIESTLYQDEGTVTEVKTSQENRYRRNLRPVEFDINGEKAKLNLVLSKRKVFSPSAPIWLVRSHQGHTPNYTYELLKNVTIDITLTLHYQCQFITRLILLFQRKDILDGDFYVDNKNKAVILVRYDHEKNTMLYDGVFGEGSARRIIHSLPENSKVRSKRANELNYNHIVYALPEVDELADSVFDTQQIVIERNGVLLDKLDVPLDTLYPKLLVVVDYHLFKLLGKDVTRTVRYIATFWNIVDQKYERLETPKVQVIVTGIVIVEDEKALNFIYRSRNETEKADIDQLMEYSRLYFSQDFVNDTSFKNYDAAILMTGLKMNLIEGFFEISGLAAKLGGICIRQYNVAIVTDSGAYRNTLIAIHELGHLLNLSHDFADECNGISYLFGSLKTSVMSSPTNGSEIYWSDCSLRLLKEFSTLKAAKCLATRHRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGU7</accession>
    <name>A0A232FGU7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_008301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000216">
        <property type="protein sequence ID" value="OXU29964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGU7"/>
    <dbReference type="STRING" id="543379.A0A232FGU7"/>
    <dbReference type="ESTHER" id="9hyme-a0a232fgu7">
        <property type="family name" value="Pancreatic_lipase"/>
    </dbReference>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="61"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="369" mass="41090" checksum="EEC29C714AFA9FC5" modified="2017-10-25" version="1">MKTTVGLILISLILVAGDMSMLMRQQPEDFLLEEVILDSLVKLMSPLLEDRAFLPNLADPVTDREIGFFLYSRSNPAEPVALRIGDVATFKTSNFSVDKPMKVLIHGWTDTGSSSWIQDFRKNYLKAGDYNVVVVDWSVASLQDYLTASRLSRQVGDHVSKFLEFLMMENIVASEDIHVLGHSLGAHIAGFIGSNLSGKIARITGMDPARPDFEYPFLREPNDRLDPTDAKFVDVIHTCAGTVGFVRPIGHVDFYPNGGSFRQPGCPVLMTRNYSQASNDKNKKIGCLNRRFSSIPEYCSHGRSHQFMSESIVNPTGFPAVECNGWKEFKANRCGSNRIVYMGEKLDTEARGVYFLETNAGVPFGRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH64</accession>
    <name>A0A232FH64_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000223">
        <property type="protein sequence ID" value="OXU29903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH64"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11327" checksum="E86E5535B7EAD133" modified="2017-10-25" version="1" fragment="single">CRLELTLYSLNAAENSGPLKQKRFPEDYRRDSKPHVPARTPLGTGLSGLAVTDRSFSLSALKVTFKIRGVNSLLRSWQSRNDYKSTPNRIGLKPGIALSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHS2</accession>
    <name>A0A232FHS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000211">
        <property type="protein sequence ID" value="OXU29998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHS2"/>
    <dbReference type="STRING" id="543379.A0A232FHS2"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016028">
        <property type="term" value="C:rhabdomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016060">
        <property type="term" value="P:negative regulation of phospholipase C-activating phototransduction signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000002">
        <property type="entry name" value="Arrestin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF16">
        <property type="entry name" value="PHOSRESTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="193"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="381" mass="42513" checksum="D6E0DB580F507F08" modified="2017-10-25" version="1">MVVNFKVFKKCSPNGKIAVYLGKRDFIDYLSGVEPVDGVILLDPGYIDTQRKIWVQLICSFRYGREEDEVMGLNFQKELYLASEQLYPRVKKMEQNLTKLQERLLRKLGPNAVPFTFEFPQSAPSSVTLQPGADETGEPCGVSYTVKVYAGETETDITHKRSTVSMGIRKIQYAPTKQGRQPCTVVRKDFLLSPGELELEVTLDKQLYHHGERIAVSVCVKNNSNKVVKKIKALVQQGIDVVIFQNGQFRTVIDAVETQDGCPINPGSNLQKVLYLKPQLEGNRQRRGIALDGQIKGDVGELASSTLLTSPDVRDTFGIVVSYAVKVKLYLGALGGELSAELPFILMRQKPTDRFKLVTADENMAVEDIPSEEKGKENYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIS2</accession>
    <name>A0A232FIS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable oligoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_013553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000155">
        <property type="protein sequence ID" value="OXU30483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIS2"/>
    <dbReference type="STRING" id="543379.A0A232FIS2"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="45"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="224" mass="25911" checksum="D46C12AA18A0EFE9" modified="2017-10-25" version="1">MSILRSFSRCLKRFTQPAFSHYYCTNVPDSNADSEDVSVTQNRNGIVWIDMEMSGLDVDKNRILEIACLITDENLNVISDEFQAVLYQPDTELDTMNDWCQNNHGKTGLIDACKKSAETEDAVDINLLYFMMKYIPKGKCPLAGNSVYVDRLFLRKYMPVSNDYIHYRIIDVSSIKEVVKRWKPEIHSNIPKKEFNHRALDDIKESILELKFYKDNVFNASTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJW3</accession>
    <name>A0A232FJW3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000110">
        <property type="protein sequence ID" value="OXU30873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJW3"/>
    <dbReference type="STRING" id="543379.A0A232FJW3"/>
    <dbReference type="OrthoDB" id="10265679at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016939">
        <property type="term" value="C:kinesin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008658">
        <property type="entry name" value="KAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605:SF2">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15605">
        <property type="entry name" value="KINESIN-ASSOCIATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05804">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01297">
        <property type="entry name" value="KAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="98953" checksum="DE6640B5BD0C1967" modified="2017-10-25" version="1">MDEAKYLKRKIRSGNLDVHPTEKALVVNYDVEALILGELGDPMLGDRKECQKIIRLKSLNADTNVTLLAKEVIDKCSLIHESKLHEVEQLIYYLQNRKNTIEDFENDGHPPRPVSSISTESGDSERAVISSIDSYMELLYDEIPDKIKGSSLILQLARVPDNLQELTKNESLLSVLARVLREDWRKSIELSINIIYIFFCFSTYSQFHSVVLECRIGSLCMEIIDYELMRYDQWKDDLEKRRRYFENTTGLCLLPVMNADGSDKKMKIMDDIWSADGPLDLQMRKRSIDGSLNVPKEEIDRLKDDLEKSRKKFKNLTKKQEQLLKVAFYLLLNIAENTEVEKKIRKKNVIGMLMKTLDRTNTDLLILVVTFLKKLSIFRENKDVMAEGNIIEKLPKLLHNTNPDLVSSTLKLLFNLSFDTKLRGKMIRVGLLPKLIKLLTQDDVNRSTILGLLYHASMDDKVKAMFTNSECIPLMMDMLLASDDEQIMPELIALCVNLATNNKNAELMVQNNRLRGLVEKAFKNQNAVLMKIVRNISQHESTKENFVEFVGDFAMALTQSDCEEFVLEIVGVMGNLSLPDLDYSQILQRCNLIPWIRNTLVPGKAQDDLVLEAVIFLGTAAADEDCAQVMCKADMLLSLIELLKAKQEDDEMVLQIIYVFYQVSKHDSTREYLIRETGNEAPGYLIDLMHDKNPAIRKVCDACLDVIAICDKDWAVRIKVEKFRSHNQQWLDMVESINIDTVAASLPPPEEEDDDSLGVFTSGDLLKHTVLFPSGSNTRLNLDEGESMTKAFTDSIETISRPVSRYSRDLDEICELMASSKSRLSMGSGIEDLYHSSKLKFDLALLTQTIFKKIALHRKRITASIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK71</accession>
    <name>A0A232FK71_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000100">
        <property type="protein sequence ID" value="OXU30983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK71"/>
    <dbReference type="STRING" id="543379.A0A232FK71"/>
    <dbReference type="OrthoDB" id="7701288at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="291" mass="32329" checksum="BD026182572D9D49" modified="2017-10-25" version="1">MKVIRSSIPQFFYLYHFTFYAYQYRFNGQYSSLALVTSWLFIEHSMLYFFHHYELPMILQQAQLQQLLYRNHAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQPQQPSNTATSTAATSSAGSTGTTSTAATSTTSAQEQRQPDQRTQHDYISDLSRIENLSDLHYTELARLMANVDLEVSDQHPEATTNPSTTESTVSSSESTTSADSTSTAKTTTTAASVTSSSSSSHAAVATGGAESSSLSEASSNESFEVIESAEATSTSAVADDEAEKSSVSRQTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK86</accession>
    <name>A0A232FK86_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mago nashi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000103">
        <property type="protein sequence ID" value="OXU30950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK86"/>
    <dbReference type="SMR" id="A0A232FK86"/>
    <dbReference type="STRING" id="543379.A0A232FK86"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17274" checksum="5DD5A0A2BBF79D2C" modified="2017-10-25" version="1">MPTDFYIRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDTMIRKEAYVHQCVMEELKRIIQDSEIMQEDDSLWPQPDRVGRQELEIVIGDEHISFTTSKTGSLLDVNQSRDPEGLRCFYYLVQDLKCLVFSLIGLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKB4</accession>
    <name>A0A232FKB4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein THEM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000095">
        <property type="protein sequence ID" value="OXU31033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKB4"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU31033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="204" mass="23842" checksum="CE9EFC1F814EF282" modified="2017-10-25" version="1">MLSYFTLACIAILYVLFDVNYFLRIAFTIGYGRLFQSKKKIFEKTTIYGICLSMDVDIFLKHMNNARYLRELDFARFHYYDRSGIYGEIAKKGGGAVQGASSTRYRRAIPIFTPYKVTTQLIYWDDRNFYLEHEFISLSDNFVRAVVLSKQSVTGLKVPVSEIIEKVEQGARRPELTKELRLWLDSMEESSLRYKKSREDAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLI6</accession>
    <name>A0A232FLI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLI6"/>
    <dbReference type="STRING" id="543379.A0A232FLI6"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13576" checksum="78DD309E638E29FA" modified="2017-10-25" version="1" fragment="single">YESFNDYVSTEILDGDNKYDAGEHGLQEAEKGVIFSSFPPVLHLHLMRFQYDPITDCSVKFNDRFEFYEKISLGQYLKSSKELTNADYTLHAVLVHSGDNHGGHYVVFINPSGDGKVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLU1</accession>
    <name>A0A232FLU1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_017003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000055">
        <property type="protein sequence ID" value="OXU31479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLU1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="218" mass="24772" checksum="9A88F737E6C69C03" modified="2017-10-25" version="1">MHSGILFKIIIVIPQNNDVSKHISTTADFSSEKQRGIRYDPTTTTPLLVAIKASMCAPSLAKEKYDHALILDPSNRTNFVYPDANGTISLLESQAVFLSCPGANNNLNVPESHRSSNFNGRESEYRRSEIGFYTVGEEYFLKVIDIYYDRSSTSTMYAKSVVSKWIAGRQKPTKQHRYDQTHCCEQKRYRLDVDKIYGAVTLDRSFAELLYNAVFVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLV4</accession>
    <name>A0A232FLV4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000054">
        <property type="protein sequence ID" value="OXU31490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLV4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="7268" checksum="B9AB6C93AB9A199E" modified="2017-10-25" version="1">MSVWVCVYHNISGTIPSIAIKFDLHIYFWILNSGKTVIFLFSQLYFLWSFFIFYVPYYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM43</accession>
    <name>A0A232FM43_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000047">
        <property type="protein sequence ID" value="OXU31579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM43"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="9374" checksum="39D3389883D40D59" modified="2017-10-25" version="1" fragment="single">ANQRAPIRGTLSARTESQLSASKKRVLDGRDRKVSARTSGKSASSRSTTMFARVTCSPLLVDIGSTIRGKLEESPECARVHESQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMX6</accession>
    <name>A0A232FMX6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000008">
        <property type="protein sequence ID" value="OXU32086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMX6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="113" mass="12963" checksum="FE2216BFACD2E686" modified="2017-10-25" version="1">MTARSSLVFFFRGTNGKRRARISTLARKILARARELWNCVGDYCGGGNSKTRGIKGSKIFEVTRCIQFYSGFRKTMFHLFKCLVASKIRTFIEKRISDLQPAKNKISIEFSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNW4</accession>
    <name>A0A232FNW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8577" checksum="63D7A201D549D721" modified="2017-10-25" version="1" fragment="single">ENKFRTLFSHRTPHSRKLQISESAFPTPIYQISKMQPLLPQGDFTANFTGLLSVRESLPCARSRMRAIAAKFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDG6</accession>
    <name>A0A232EDG6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DAZ-associated protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Deleted in azoospermia-associated protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline-rich transcript in brain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_005377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes. Plays a role in stress granule formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006392">
        <property type="protein sequence ID" value="OXU16399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDG6"/>
    <dbReference type="STRING" id="543379.A0A232EDG6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022730">
        <property type="entry name" value="DAZ_assoc-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638:SF3">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11029">
        <property type="entry name" value="DAZAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU16399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="11731" checksum="6B40044A2BE01145" modified="2017-10-25" version="1">MLKKFDLQSTYGPLQYYPPLAAATAYYHTAMQPAPVRPTIMQNGFDGARFDGISQPALPPPPPGVPANAAQLAAMAGHSVALSQKRFVLGRRNGGWLHLLVNRMASQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDP7</accession>
    <name>A0A232EDP7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006056">
        <property type="protein sequence ID" value="OXU16471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDP7"/>
    <dbReference type="STRING" id="543379.A0A232EDP7"/>
    <dbReference type="OrthoDB" id="8194903at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="510" mass="58953" checksum="1A84409EF565FCA3" modified="2017-10-25" version="1" fragment="single">MSKHGPYKNYLDRYSTNVTIPRTTKLAQNYKETQRKKNSKLKENLKQHDEYQSTMQGQSSSSSVADAAFQIDKDLNESIIYNNELKSVNFTTEKREHLLRRTVCKCTTVNVAEILLLCTQLVTKHSLTWIALIDIFKVNFTTEKREHFDINSLPTTKYMINNLMNVTTNCLSYHIICHECNAYLGKKLDFKDTVTCTCGCQLSSSKMGTFFIEINVRDQLKNLFSDQIVTNRNPNNLSYTFNTDGCQAEDHSKVTIWPVYLMLHELPVRMRKKNMLLAGLWVAKEEPDMNIFLEPLVTQANELSDKGFQWIHNGIKITSKLFPLGCCVDSVARCSVVNMKKFNGYNGCTYCEHPAQLVNNICKYPMQNDVPPDRSDESIKRQMFKAYQQNSGDVQGVWGPSSLMNMKHFDLARGMILDFMHSCLLGVTELYTRILLENAQKKYYIGSPARIDIINNRLMSIRPPTCIAKTPRSIKERNMWKASDWMNWLLFYCMICFKGILKLKYYNHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE80</accession>
    <name>A0A232EE80_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Retropepsins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_009614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005488">
        <property type="protein sequence ID" value="OXU16660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE80"/>
    <dbReference type="STRING" id="543379.A0A232EE80"/>
    <dbReference type="OrthoDB" id="7615906at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retropepsins" evidence="7">
        <location>
            <begin position="134"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU16660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="264" mass="30548" checksum="892F354D62D3B323" modified="2017-10-25" version="1">MELSEKEVGAFKQNSVSVDYLHANERPNRKQPKSNFNQKFEKSSTNTNTSKPQSKRKVTCYRCGDNHTIPHCQVSPRITCNFCGRQGHMERICLKKREETHYVDEENSEEEYIDIVEICPVDEPKLRDKIYTVLNIQGKPIKMEVDTGAAVTLMWHHQATKLFPEIQIKKTTLRLVTFCKNTVNVNGYLTVKVTYENKDYQAKLYLTEVERAPLLGREWIRCLITGGSASGLFSEILQVNFNVQDVNKEVFIKKLFNKYTNVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF63</accession>
    <name>A0A232EF63_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_013027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005096">
        <property type="protein sequence ID" value="OXU17006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EF63"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="701"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="945"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131097" checksum="F27B243F6C5A5178" modified="2017-10-25" version="1" fragment="single">MCSSVNIDELLLRAVAEKNEEKIWRCIQAGADVNHRDLMSDLTPLFIIATCGSRFIRATDDEELAQLRARIATLLIESGADLDSLTWFEGEYFADYMTALQAAVYFRNVVLKMCSSVNIDELLLRAVEEKNEEKIWRCIQAGADVNHRDLMSDLTPLFIIATCDSRFTRATDDEEAQLRARIAVLLIESGADLDSLTCSVNIDELLLRAVAEKNEEKIWRCIQAGADVNHRDLMSDLTPLFIIATCGSRFIRATDDEELAQLRARIATLLIESVSCSTTAPTSTLSHDTTALPRFTTPXEKNEEKIWRCIQAGADVNHRDLMSDLTPLFIIATCDSRFTRATDDEEAQLRARIAVLLIESGADLDSLTWFEGEYFADYMTALQAAVYFRNVVVVSVLLDYGADVNAVSRYNGFTSLHYALDDKFSDVDIVKKLLRVQGIQVSSGCRKHGNTPLHLAVMREKDSKELVELLLKHGADTEKKNRRGMNPVQEYLENAISLRTRNLHFRGIKPALLKLIPPSESDTSQLHLACVFHGTSEVRKMAIADRGTINARDRFGHTPLSYAVLARGASTTDRNSTVRLLLNLGTDISQQFGRYQPDANDGLDQDEEGSYSILDIAILLGDHQVSLILLQHLAKLDALMQSDYEEETLSEFNLDLIHWRDEQQRMSDLWRYXDDKFSDVDIVKKLLRVQGIQVSSGCRKHGNTPLHLAVMREKDSKELVELLLKHGADTEKKNRRGMNPVQEYLENALSLRTRNLHFRGIEPALLKLIPPSESDTSQLHLACVFHGTSEVRKMAIADRGTINAQDRFGHTPLSYAVLARGPSTTDRNSTVRLLLNLGADISQQFGRYQPDANDGLDQDEEGSYSILDIAILLGDHQVSLILLQHLAKLDALMQSDYEEETLSEFNLDLIHWRDEQQRMSDLWRYCVDCREELRAMKRSKVGESPXNTPLHLAVMREKDSKELVELLLKHGADTEKKNRRGMNPVQEYLENAISLRTRNLHFRGIKPALLKLIPPSESDTSQLHLACVFHGTSEVRKMAIADRGTINARDRFGHTPLSYAVLARGASETDRNSTVRLLLNLGADISQQFGRYQPDANDGLDQDEEGSYSILDIAILLGDHQVSLILLQHLAKLDALMQSDYEEETLSEFNLDLIHWRDEQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFJ2</accession>
    <name>A0A232EFJ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005001">
        <property type="protein sequence ID" value="OXU17126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFJ2"/>
    <dbReference type="STRING" id="543379.A0A232EFJ2"/>
    <dbReference type="OrthoDB" id="7697313at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="408" mass="46013" checksum="8220967A868073B7" modified="2017-10-25" version="1">MMSRGSSSSSTSYYRPSTCTPRAVSPPRNYRPCHLKLPQLLAAASNAFSPRCSEIDYPTTSWTGCCSSARTSLSVGEEPFAQSRRIGKTDQMPLTCRSQSGSPYYTKYLEGKVTTIQEKHQTVLAENTNLNNQLSKATARTQELEEKAAQLEEALRKEKQQSHVALHHRAVNTAGVASSLEESTSTMAHSFVDLSIQTISLEEVQQTIVDCSNTDDADLISISKSELDALENDMKSLRDAVRAKEELWDQAVAREQSYREHLARLSIELITIRQLSDSRLDELQRVEKKLTENNDELRATQKDLALAKKAIVKLQKRQRQAEGSGINQEQPSDDLENKQQLNPQVRSPLSKQRSPKKMHQVQVKDARCTAPIQQRHPPRDYSPRIETMRTKETTADKDFNDLRNNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG31</accession>
    <name>A0A232EG31_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_009346</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004879">
        <property type="protein sequence ID" value="OXU17306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG31"/>
    <dbReference type="STRING" id="543379.A0A232EG31"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03706">
        <property type="entry name" value="mtEFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="14 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="17">
        <location>
            <begin position="61"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU17306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="473" mass="52470" checksum="FFE67E63C6F546A1" modified="2017-10-25" version="1">MALVSARTVLYPALRQTVRQLNFTRQLAKYQRRNQLCSRLYLPEVTVQRLYAEKVVFARDKPHVNIGTIGHVDHGKTTLTAAITKVLSEKELAKAKNYNEIDNAPEEKARGITINVAHIEYQTENRHYSHTDCPGHADYIKNMITGTAQMDGAILVVAATDGAMPQTKEHLLLAKQIGIEHIVVFINKVDAADAEMVELVEMEIRELMSEMGYDGDKIPVIKGSALSALEGKSPEIGSEAIMKLLEQIDGYVPVPVRDLDKPFLLPVEGTYSIPGRGTVVSGRLERGKLKKGQEVEFVGYNKQFKTTVTGIEMFHKILETAEAGDQLGALIKGVKREDIRRGMIMAKPGSVKAYDHVEAQAYILTGEEGGRKKAVQDHIQLQMYSKTWDCPAQVTIPGKNLAMPGEDAKLDLKLLKNMVCEKGQRFTLRDGSVTVGTGVITNLLAPLTEDEKMVLVEGKKGLRKLERKQQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGC3</accession>
    <name>A0A232EGC3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004794">
        <property type="protein sequence ID" value="OXU17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGC3"/>
    <dbReference type="OrthoDB" id="7549643at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="245" mass="27890" checksum="06E580B502A37A03" modified="2017-10-25" version="1">MEQLKFHLQVAKVAIRVFTRGHDNWRYLETVLSHINNTRDCAINQAYLLRKCLHSIAEDITQDSAQKFSDALYCKLHSSVRTAATSIYSGRGSNGIIGQWIKRASTVRSHISTILWCSQMISQEKNLGNVHSVNVLFAMIQLNDIVQPRLQNILPNMLLSTTYAVNKSNSKRISLSLECHQGSFRPVVKCSTATGSFKSIKFDVASWKDLIDSFSWGFQDAYRFQSEYGRPTKICMENHDLMFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHQ1</accession>
    <name>A0A232EHQ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004438">
        <property type="protein sequence ID" value="OXU17897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHQ1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="14868" checksum="ECF84F0458F8C839" modified="2017-10-25" version="1" fragment="single">APDNANERNKWLGFKITPTASINVKLLRPRLNPEELPYEHDKCLEPPRKVIKLCDKETHKASTSATSTSASIHEAIDIHCDSSTVVADASNVVENKEDSFIENILEIQILPEIVRNGMLSFDEVSVITSIEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI23</accession>
    <name>A0A232EI23_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004382">
        <property type="protein sequence ID" value="OXU17972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI23"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="359" mass="41087" checksum="727ADDBD40CC5738" modified="2017-10-25" version="1" fragment="single">MKLAMRQLIFLVSVNSKLFIEYYIKIKIKKHSQSNKLPRKSISLSQSFGHFAVKLDDSSRNQDEHFYDFYLRLQNIVRIANNQLERSKPQLSNLFIRQLDVLAGMVFVRKLRNYLYENVYKLASETLDDVAKLAIYIHSSNTTGIKSLRGEYSNSPTEIREEMKNYFIALRFKNVYTVLKQYDYQKSIPSAENDKNCECDRAPGNSATVSDHNSISDSEGTSKFSVSSERSKRLLHKSNRPRESDLTDSERTKDTVTENDGETNHPVLRHYCIRIVSRVSSNSDKLNKRSYVLSKAAEAGLGQYPDCRLPFGYHWGPVNDLNSWMEPNRFRKAGESVCPRSITPSQGPSLSVSLLTTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIH8</accession>
    <name>A0A232EIH8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_011769</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004275">
        <property type="protein sequence ID" value="OXU18118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIH8"/>
    <dbReference type="STRING" id="543379.A0A232EIH8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850580" description="ABC transmembrane type-1 domain-containing protein" evidence="12">
        <location>
            <begin position="23"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="110"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="385"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU18118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71879" checksum="B6D3E5452A1BF7CE" modified="2017-10-25" version="1">MFAALAITVTLVISSTTHPLHATMTKKQHELRNHKNLRLVIPGSGDSNVVLQHPVKNIDYRKEAHEANGEKNQISAEPEEKGEKEATIEPITFFKLFQFTTGFEKMLMCLGVICGIISGLAIPGNIYIFGKLVGSMVKAEMGSGINPQNVSIAGDMNITNGFVMEAVTEFAIGNSAIGVILLVFTYFGVMLFNYVAHKQSFRLRTMYLRSVLHQDIAWYDLSKSGEVASRLTEDVIKFEDGVGEKVPMFLHNVFAFIGSLGLAFFTGWQLTLVCMASVPVMTLVLACIVRVSSTLTRREVEVYAVAGSIAEEVIAGVRTVVAFAGQAKELTRYTASLDMTYRNNIKKGLLSGVGQGVLWLSMYASYALSFWYGVTLIIDERAKLLEEQTYNATTMITVFFSIMMGSINLGAATPFVEAFGISKAAASKVFSVIRRKPAINSLTDEGRRPGDIQGSIQFKDICFEYPSRTDVKISIDGHDLKEFNVKWLRNCFGIVGQEPVLFDTTIAENIRFGDLDAPMEKIVQAAKEANAHNFIMKLPNKYDTLVGERGAQISGGQKQRIAIARALIKNPRILLLDEATSALDTRSESKVQAALDKAHKGRTTIIVAHRLTTIKGADKIIVISEGGVVEEGKHDELMERQGHYYSLVTAQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIS2</accession>
    <name>A0A232EIS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BLOC-1-related complex subunit 6 C-terminal helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004198">
        <property type="protein sequence ID" value="OXU18211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIS2"/>
    <dbReference type="STRING" id="543379.A0A232EIS2"/>
    <dbReference type="OrthoDB" id="21270at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019314">
        <property type="entry name" value="BORCS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046465">
        <property type="entry name" value="BORCS6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13440:SF7">
        <property type="entry name" value="BLOC-1 RELATED COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10157">
        <property type="entry name" value="BORCS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-1-related complex subunit 6 C-terminal helix" evidence="2">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="270" mass="30008" checksum="FE2C54B1B0C3F624" modified="2017-10-25" version="1">MNVDVSENGKPNQLANRTEAHPSETTDYDDDRLQEMTASYSEISFDSPSSPPASDIRSLIDSPDLSNGMYLTDKTNRPDCLDLKNTDELEISNSGCDPVSYEKAMGYLQSEGTVMKEGDMVLFVAEDLENKIKLSSPITKKGETSFLDSRNSTPCLYRQALTPQLPALDHNILNELENEARKVATSVDSITENLAAILHSASALTVGCLETYRDAVCKTCDAVDYNIKSMYQLMAKCEELSKSMSVLYKLSEKVKDMKKMLELFENTMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIS3</accession>
    <name>A0A232EIS3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004172">
        <property type="protein sequence ID" value="OXU18245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIS3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="18897" checksum="332E4C1A0A2A0803" modified="2017-10-25" version="1">MKLDPLSRKQTTTSVWKTLALAKKIWEKIREKLHSVDMFVSVAMNIHKIFENDVATIIGLVKRPEDEQVAPNKSTESLELMLSQTVRTLILAKPPTTMMLVKSGLMPKNGRKCLQAIGGKTKDSHKKQRKIMRKLLRHVHLNPQCKILKNKGKCRGRRLPRGKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIY1</accession>
    <name>A0A232EIY1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004131">
        <property type="protein sequence ID" value="OXU18327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIY1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="14454" checksum="B9782363C11C3F8C" modified="2017-10-25" version="1" fragment="single">TDRSGAIQGGGTANNNTLETTAIKINCNNNSLTIVSVYAAGHNKVSDLNASSAEWDDAATNSRCGYINGWLNTKSIVLRLRALPPAEPTVSRSNSFLDIYLADSRITFSNTVNNKISVIDYYSDHKALFMHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIZ5</accession>
    <name>A0A232EIZ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004123">
        <property type="protein sequence ID" value="OXU18337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIZ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="35" mass="3748" checksum="9EDE8CE7BAE12C01" modified="2017-10-25" version="1">MVSVHSAGAFDGDEEEPVPLISSCSNERDLITLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ62</accession>
    <name>A0A232EJ62_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004121">
        <property type="protein sequence ID" value="OXU18341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ62"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="139" mass="15639" checksum="1459963AFF57B402" modified="2017-10-25" version="1">MGSTVIPRIESTISHEPRKPRDAPHTIQEFDSSERAANSRINSIIAGRSSRAHKSRARLSANARRSQNSSRFRSPATCLFSRSRCDESRCVRHSYIASISKFDRLSKRENCFRKLIPTTNNNASDGENNTLAVTCDFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ75</accession>
    <name>A0A232EJ75_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004095">
        <property type="protein sequence ID" value="OXU18372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ75"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="14161" checksum="5033E20C1897D84A" modified="2017-10-25" version="1">MVLTRTGKGKDISKMTDPQVIEELREQIARLSAAQTRNLLTIAEPIKITLEQYYMDVEQFGAVWSIFVSNQKFAALRRRPGSRSPGKDIVNLAVETWLRFRRTRNTDPKASQRANATTPCTEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJS0</accession>
    <name>A0A232EJS0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003943">
        <property type="protein sequence ID" value="OXU18609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJS0"/>
    <dbReference type="STRING" id="543379.A0A232EJS0"/>
    <dbReference type="OrthoDB" id="7700376at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="216" mass="24640" checksum="6A1F7F6560A52907" modified="2017-10-25" version="1">MWYPLISISEITTSNGKKLVVQDKNVIMKHIPVKTLLKNLLEINGLFNALTEYMEFLNNDKTAKTNVIQGQLWQKQISTFHKNGIVIPLFGYFDDVETGNSLGSHAENNEVGSVYVMLPSLPPNFTSKFESIVLSDIFYTNDRKQYSNDVIFKRFINKLNDLRENGIELVIEDKNESRTVKEYFITTLILGTTLELIVSLDSHRISRKLAGAEFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKA1</accession>
    <name>A0A232EKA1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003859">
        <property type="protein sequence ID" value="OXU18752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKA1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="27242" checksum="F65A69A65990DAC5" modified="2017-10-25" version="1">MYLFNHLSKKNKRVVISNANPSIPNEVLLKVLKDIGIVAVFQMHYIRASSSKPGRSHIYSFRRQIELNEYTSTRNLRIVPHVNKRDIEVCPEFRTLTNSSNHPQELEDNASTDTPVQLNSIPKPTENSTNDRPNLKRPSASTSSEGTLTTNRLVNSGEKQIQHKPKEQPFRKHATKKFKLNTDQQVQDEVVVQTDNIEESLLPVKKRIEDNPHKYVLNYYDIQSVIEKTFGQRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKJ1</accession>
    <name>A0A232EKJ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003779">
        <property type="protein sequence ID" value="OXU18879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKJ1"/>
    <dbReference type="STRING" id="543379.A0A232EKJ1"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032072">
        <property type="entry name" value="DUF4807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36693:SF1">
        <property type="entry name" value="GH02722P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16065">
        <property type="entry name" value="DUF4807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="259" mass="30256" checksum="AD508FCF6CEA7735" modified="2017-10-25" version="1">MNCQVRLLIYKKAFIYDDLLVSSGFVYDYKQDYMKEQIKLQESTIDDNLVQQKINFQPISLRKRGLNAYLVSVYTYTMHWSNVYRKSAVDLLLRFAKANATVLNTTNFVILIKLRTPKYQYLDYGWNERITQMVLERQEIDHAMSWLSTLGGAFSALGDQFNHCAQVAGKISVQQFRLSVRLGDPQLVARCKLYAALSLLQQGYLKVTKHMVRDIYKFAIADKDTRLQKMCQGVWAKLTYCYSQRKVSKRQSSRYISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKX6</accession>
    <name>A0A232EKX6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003714">
        <property type="protein sequence ID" value="OXU18968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKX6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012918003" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="21320" checksum="0175DA446FCEF5A2" modified="2017-10-25" version="1">MNSLSVSLFIAFAIFTQSYECRKVEPQVKVVDTDTWYYNKEYVNALKYIVTKGNATYNHITLHWDLKKDLPADLRLISKVYVTDSSYKTGHLLLIDDTPVCVKSDHYELLPKVLIVDESLLNGKCIKKGVYDMEDMGQLRFEQLVPDLHKEGNYYKVDYRLGTDTETVLIATFYTEWGYLKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELK5</accession>
    <name>A0A232ELK5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_001960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01003564">
        <property type="protein sequence ID" value="OXU19192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELK5"/>
    <dbReference type="SMR" id="A0A232ELK5"/>
    <dbReference type="STRING" id="543379.A0A232ELK5"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045495">
        <property type="term" value="C:pole plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="63"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="244"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU19192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="405" mass="46389" checksum="CBFFF79A6AD34A33" modified="2017-10-25" version="1">MAEGRSRRVPAAQNEDLSNVEFETSEDVEVIPTFDNMGLRDELLRGIYAYGFEKPSAIQQRSIKPIMKGRDVIAQAQSGTGKTATFSIAILQSLDTQLRETQVLVLSPTRELATQIQKVILALGDFMNVQCHACIGGTNLGEDIRKLDYGQHVVSGTPGRVFDMIKRRVLRTRAIKMLVLDESDEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPHEILEMTSKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLAEKMRESNFTVCSMHGDMPQKERDNIMKEFRSGQSRVLITTDVWARGIDVQQVSLVINYDLPNNRELYIHRIGRSGRFGRKGVSINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELV6</accession>
    <name>A0A232ELV6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mesencephalic astrocyte-derived neurotrophic factor homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">MANF/CDNF-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_007526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARMET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003488">
        <property type="protein sequence ID" value="OXU19340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELV6"/>
    <dbReference type="STRING" id="543379.A0A232ELV6"/>
    <dbReference type="OrthoDB" id="5597848at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000003">
        <property type="entry name" value="Mesencephalic astrocyte-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.30:FF:000003">
        <property type="entry name" value="Mesencephalic astrocyte-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045333">
        <property type="entry name" value="ARMET-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019345">
        <property type="entry name" value="ARMET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045332">
        <property type="entry name" value="ARMET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990">
        <property type="entry name" value="ARMET-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12990:SF5">
        <property type="entry name" value="MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10208">
        <property type="entry name" value="ARMET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20145">
        <property type="entry name" value="ARMET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU19340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="161" mass="18738" checksum="AA8B4500251E36EA" modified="2017-10-25" version="1" fragment="single">FKDCYFSKIYFLFTVCVATVNKFANTLSDDVKKDHKKIETEFRKFCKGTKSKENRFCYYLGGLEESATGILGELSKPLSWSLPADKICEKLKKKDAQICDLRFEKQIDLNTVDLKKLKVRDLKKILNDWDETCDGCIEKSDFINRIEELKSKYSKSTKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM10</accession>
    <name>A0A232EM10_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003459">
        <property type="protein sequence ID" value="OXU19377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM10"/>
    <dbReference type="OrthoDB" id="7680010at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="270" mass="31400" checksum="2EEB8FF8108500C2" modified="2017-10-25" version="1" fragment="single">VCIIDFSRQHHRKVDSRNYIGRKTKPKFCSANKKLKSSSARTLSSLDYLEVDFEGYRIFYMRLLFTFLENNLMCKCGDGNYSITCDKCLHEKNFHNTKKIGKKSNIFEINRRSVLTMRLVGGGLESLRTFSGVMDFLPPIQNATFTKIRNVLFEIISRVADKFMSEAVDEELRLTRTNSQNEICEPESVNPEAISQLSIEDLDENMLNNKSDVTNTPYEIVACKREIGIQGTWQRRSHRSCNGFFFVTAYNATSMKKFMDQKQFLREYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN28</accession>
    <name>A0A232EN28_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_010398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003246">
        <property type="protein sequence ID" value="OXU19738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN28"/>
    <dbReference type="STRING" id="543379.A0A232EN28"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07567">
        <property type="entry name" value="biotinidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012101">
        <property type="entry name" value="Biotinidase-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="706" mass="78381" checksum="B6BFD2410C68CCC6" modified="2017-10-25" version="1">MFLTKNSTMLPNLLRVGILLTLSKPSLQTSAANSSSYIGAVVEYHPVTDGDDGQMIAEANANNYRTIIKNASAYHADIIVFPEFGLTSLPKDGDAERQFNASAYRAYYRDVASRIPGPNEAVVLCDTDSKYAKSLQSISCAAREYRMYVAVNHHERVDCDPKKPNCAPDGFLLYNTNVVFDRSGRVAARYRQYNSLVDDGVNTTSQPEQSIFKTDFGVTFGQFVCVDLLFQKPATFFASNPNVTDVIFSTHWFNYPPFLESTQIQAAWAYAADVNFLASGYNDVLTASGGSGIYAGKSGPIKTYRPSQTSNALLVAEIPKLNRRQRIEDIHAGKSTIHKFRQAEVPTISGIPPKANLTTEFRDNLRPYTSALIQTGEASSHITTLCDRGLCCDFHVETSYDKEVAAKPGAKQYRYRVVVFNGVTNYVTYSGNRSTAGVEVCALVSCAGDSLEDCGKRYPEGTDVVSPTRLESLIITRRANRNAPTFYMPTTMERTNREPLSSSDFAYLVSGQRNSSLLLMYLVRPRSDLETFGIYGRRFDKDGLPATKANGVGSVESTSAVLFCTMVFWKIDTCELYEKYQALLADSNFTVISNWIIGVYDRYRKLVNMVEASYITDPKDNVVPIERVKDTTAEPELSTFKTDFEVTFGSGIYIGRVGYNQFVSEEKASNVLVVSEIPKMKRANKFKTAEIDITDPILALENGFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP83</accession>
    <name>A0A232EP83_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 protein zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002997">
        <property type="protein sequence ID" value="OXU20148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP83"/>
    <dbReference type="STRING" id="543379.A0A232EP83"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00068216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU20148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="326" mass="37039" checksum="69348621D850A83E" modified="2017-10-25" version="1">MSVDKEELVQRAKLAEQAERYDDMAAAMKSVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEGSERKQQMAKEYREKVEKELREICYDVLGLLDKYLIPKASNAESKVFYLKMKGDYFRYLAEVATGETRNAVVEDSQKAYQDAFEISKAKMQPTHPIRLGLALNFSVFYYEILNSPDKACQLAKQVHTRTHDNDDAALCVQLERNNRGDTVVEDSQKAYQEAFDIAKAKMQPTHPIRLGLALNFSVFYYEIINSPARACHLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDTQGDGDEPQEGADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPG5</accession>
    <name>A0A232EPG5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002951">
        <property type="protein sequence ID" value="OXU20231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPG5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="11151" checksum="6B85C514BC25DE55" modified="2017-10-25" version="1">MAWRHPIEDLREQLIYEEDDEYDEYANDNEFMGFQDPVINVQNRLQEMLIADEVGEEIHLRIILIITQTVLTVKIMLHNLLVNRIIPHVVVLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQI7</accession>
    <name>A0A232EQI7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002754">
        <property type="protein sequence ID" value="OXU20625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQI7"/>
    <dbReference type="OrthoDB" id="7634903at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="100230" checksum="3710347A2BEE812E" modified="2017-10-25" version="1" fragment="single">FEWAFGLNRICLNFIGVWPNEVDANAARVKDSSIKYLRIPAMLILILVGLIVPQMYAITKVYKRLQLVLDNLTLSYCTITSFIKLFFLWKSRGVYGPMLRSALLDWQSSQGSLWEYEIMRKQARRAQIFTLSGYIVMLFSFIVFIIFPIFGLSIRIINNITDTAGEDRFLPIQTYYPFDVNRSPYFEMIFVSHVIICSGAASCFSIPDYFFGALVFHASAQCEILAVKVQQLFPPQVEAGISNTFLENKFFRTKIKQLVQRHVHLISFVETIESSFNLIILAQTICLTLIICCLGFNIIMEKQINYFQKHNEQKYYSQSLGTESNDSPILPVVSLGGSTLTILMHMLVYCFASEILAMHSEGISEAAYDCDWYTLPVNCAREIIPIMVRASYPLKLSAGKFFYLSLNAFLSIVKTSFGYVSVLLALAPERSESAERRVKLNHLSQECRIEFYRTFLIKVVLIYTVRLAHECDKHDFEWAFSLNRICLKAVGVWPSELDELDTRGVSNNRNHLRIPIMLFTMWFGLITPQLYALAKVYRQLQLVLDNLTLTYCTFTSFIKLCFLWRSRRESCPTVYGPILRSALIDWSGSRSSDWKYETMYKQAYRAQIFTLGGYLVMTFSFACFMFFPFFGLSIRIINNITDPGGEYRFLPIQAHYPFRYDRSPYFEITYATQMLIGCCAASTFTIPDYFFGALVFHASAQCEILAAGIRELCLEELDTSSTEKPRELGIFRTRLRHIVRRHVHLIRFVNNIEKSFNMVILAQTLNLATENNSESLPILPIVTLGGSTITMMCHMLVYCFASEVLAMHSESIGTACYGSDWHLLTADCARNVIPIIARAQHPLQLSAGKFFYLSLNAFLSVVKTSFGYVSVLLAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER26</accession>
    <name>A0A232ER26_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01002678">
        <property type="protein sequence ID" value="OXU20791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER26"/>
    <dbReference type="STRING" id="543379.A0A232ER26"/>
    <dbReference type="OrthoDB" id="430238at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="7">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="346" mass="39409" checksum="024750F3547C57C8" modified="2017-10-25" version="1">MADITRETGNQIIKTIMGIKTTEVAAVLRHIVGGGCIRTDPKKVEAAAKYPIPTTTKKVRQAVAFFAYYRIYIKDFAKIAEPLYDLLRKNVKFHWEEEQQTAFDKLKEILCSEPVLAASDLSQPFVVTCDASDYGLGAVIGQGKIGQDRQCAYTSRPLKGSELRYSTYDKELLAIVFAKEQFRHWLYGRKCSVVTDHEPLKHIGSTKKVDLRFNRLKAALRGYEFNVVYRPGRTNVNADALSRNLIIPEGEKNPELPRAQLYKLSSEQEYGNSDLDEKSPPARLFVIKANDENIITKLQNKKRPHPDSENSLTNIPRKRDKETNILFRKGEVLAVRNEEDTFFCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER64</accession>
    <name>A0A232ER64_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002671">
        <property type="protein sequence ID" value="OXU20807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER64"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15265" checksum="BBC400B6564CFED6" modified="2017-10-25" version="1">MLGETLGAGNGRGYPRAGNGETNPNDEYDYEPEYSTHNTSQKVVSERLSQGETKLEGYSVYSRNKDTIINGHQELRGVVKDSVRGTNSIETDGIEIQREGGAHSCVYTQRAQVVTAEPLPRHEKTMKRDTTEFKLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERI8</accession>
    <name>A0A232ERI8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002612">
        <property type="protein sequence ID" value="OXU20942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERI8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="11835" checksum="D4244FD96BD3D6A3" modified="2017-10-25" version="1">MQLIALYGAFYACDVAARANQKPAISSKEVRKNKPKGDAAKKREKERKLLEQSSKNCNKIDELFSQQTKLKNNAFPKSQNETEINDTSISNDSIEQEKERNSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERU0</accession>
    <name>A0A232ERU0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002580">
        <property type="protein sequence ID" value="OXU21006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERU0"/>
    <dbReference type="STRING" id="543379.A0A232ERU0"/>
    <dbReference type="OrthoDB" id="7779986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="79" mass="8711" checksum="1F6571AB4CEED606" modified="2017-10-25" version="1">MGIFLGEAEARRKILRGRKTITRRYYKGTAIPAWSIAVISGLSMLVVGAGLYLLLKKLVIDSVEVSEVPSYQPAMQDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESU9</accession>
    <name>A0A232ESU9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002374">
        <property type="protein sequence ID" value="OXU21422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESU9"/>
    <dbReference type="STRING" id="543379.A0A232ESU9"/>
    <dbReference type="OrthoDB" id="4713066at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="8">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="13630" checksum="335A269762494E12" modified="2017-10-25" version="1">MNKNGPPPPYDPPPTAPPSYAQCVGGVPPASPFTPAETYFQNVNGPTIVTTIVPLGPGSTHTICPHCYAEIDTATRTEPGMVAYISGFIIALLGCWAGCCLIPCCIDDCMDVHHTCPNCKAYLGRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET80</accession>
    <name>A0A232ET80_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002344">
        <property type="protein sequence ID" value="OXU21506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET80"/>
    <dbReference type="STRING" id="543379.A0A232ET80"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="187"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="641"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1279" mass="147969" checksum="30AB0EA9C1BB1617" modified="2017-10-25" version="1">MYYRDPPKTEEENDPCCQHGDFQTLPTSVVLSSFSVTDNYKEIEDIRISNKKITLLQEPNESLSLSCQIHHDGFVKTGSLYVCNLELSFDNDLHHISQSYCYDISLKAMISKRGIVFHVPLSTDRLIRKENKISSYVNFFLNTDNIDSSQDCHMCCSINRINLATSSADPELPLGEALLLQKRYALPNARLLVDNYELTAHRSVLAQYDSVFYDMFSREDSAECRTGVVEIHDFEAPEIRAMLQYLYTRRTNGFISEFPVKLMKVAHEYKITGLIAKCQEAMMFEMRQDNVIEFLELAKSCELEELKRSATTFIAEHEEEMLGDPRYLLFLQRDLSVDNLAKTLKAIAKHGELSSIKDKTFEFAKENSAELAENDDYLGLFESHPQFMKEITDHDSAKISDKKRWAFSLTFPLRCPLESLVAFERSESEVLIYNKIQSSTVYFIQTVTMETVATRKILEITKNKTKPTKKSADNCTDCHEGGFPLVALKTEHNFVSWEFVCPRKVTLKECPKESLILDLKRNHCNEYNLIIQFENKLHEVSEDYYYEINLRVHYSQDKRLYHVPMFSFTELRGTDSVIFEDFQLDIRVNSTGFTNIVTYNNIFCLQRAKPLHICCSIRRSNTIFKKSELPRDTLLRENLLSDVCLKVKDREFQVHRAILAMHSTVFRAMFSHAVTSESRTGLVEINDIEAPVLEEMLRYIYTGNLNEDGPKFPVKLLKAAHKYDIDGLVSRCEEALLFQIRFTNVVEFLDLANLYDLKTLKRGAISFISKHEEELIMDPIYQEFLRRDLNVDTFVNTLKLCSKYELPEVKSAAFEFVKRCGKEIMNHEEYLKLLQAHSDFTQEMLSHARLSNIAIDGSNSIFSAKIHPRCCFTASIASKPQVRQLIRDSMTEPCNTAGLSESSSKPYTWLVYDDESVNDACVAFALPGIALRQEPSESLDLEYTSRYYCDVDDEHHLNKYSLRLVFRNNLHELARDYGYEVVGSALLPPRDATDDEAAVTERPYHQLLFAHRRRRLTGSIEIKEIFSVRRSRLLHLCFGIRRFRDRDDQDVEEPAEPHAAMLLRTGLYSDVKLKVNGRVFPVHKHLLSSRSPVFRAMFGHGEVFPENRANGCVVIDDLDPEVVEQLLVHVYTGEAPKLASMSRQLFEAAHRYELAELRRACEEFFVFGLSRDNVIEILDMAGLYELKELRQRALEFVRNHETEMATEQNFRSFLCRDLRINGVADTLRMCDKYGMEEVKAKVMEFVKEHSRELAESEGFLGLFRTHPDLMREIFVYVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETE5</accession>
    <name>A0A232ETE5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002300">
        <property type="protein sequence ID" value="OXU21587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETE5"/>
    <dbReference type="OrthoDB" id="6740702at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="144" mass="16970" checksum="37E41D9234079C35" modified="2017-10-25" version="1">MFVSIKIELRLISRLKSRFNQGSINLDIFERVLTVTPGGLDEEVTKTEEEEEESVNGEGEEETAEEEEEDHRDDEEMDVEQNDFIRLPGERFIIHGHETHYVAKYRLDGRRLLLKIHSLSKKNINPTIWLELAIRHLCIFNFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU19</accession>
    <name>A0A232EU19_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterile alpha motif domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_005061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts promiscuously (via SAM domain) with EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3 and EPHB4 (via SAM domain) (in vitro).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002207">
        <property type="protein sequence ID" value="OXU21807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU19"/>
    <dbReference type="STRING" id="543379.A0A232EU19"/>
    <dbReference type="OrthoDB" id="10047268at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000055">
        <property type="entry name" value="Sterile alpha motif domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058666">
        <property type="entry name" value="SASH1/NUB1_homeodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF8">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26285">
        <property type="entry name" value="SASH1_Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="775"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="850"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="730"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="949"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="992" mass="110513" checksum="8E7702EED82E0CF9" modified="2017-10-25" version="1">MSEPPEENVSPSPSAWKMSIASNIVVEWLHSLHLGEYAESFLDNGYDDLEICKQISEPDLDAIGVFKQSHRLRLLQSVKRLREEGAASVYFSLEESSACLCSASQQDCSSQELLSAAPTPDKEEQAAPKPPTKFIDEYEEGKAELVRIPRMQLRLLLQDKLRTDGIRLACQPYTTPEGERGYLEGLASRYADLLRTHYGDVLEPLEELRRRETDANLRMTSTQLTTSHSQPIYVPGKYSPSSCLSDKEEDEIYGFGYGVFGRQMMQQRQQKLALATQHLTLANHSMQQQQQQSLYQSCLSPRSAFFYEFPPNEQGQNTSKKKTTFSRILRGLKTVRKDKHNQAQSSPRHNPPRSGVPQRVDTPDSVLQSGLGLTPDTGHTVLRSMVDPRDYDRLKYLQANGSQANTFEETIHRLKVQEALRKKERFNKEHEDILKDIRQGLMLLGREDKCQYPDDTYMYDEEARCGDMHTLEVVGGGIQHWYDEPPYESDPEDFLMVCNTGEAAADGGSNARIENGSRLCYRMNVEPDNRKESVISLRTAGDISLPKDRSRKLSSSTMRGLIVPQGHNNPPTIIPLTHSRTSRESGEYASSDVQSRSSGEEDENEESPRSQSTDYEDPDPAEEEANKAWRAQQYTAPPPLDRNCGSTRICAPAPTVAVGVAAGPGAGIAATSAVRARVGLGEGAAAVGIAGRARTLRQDVQRKINRLRQQRGSISEAGFPCSASSLESLPSGSASSSTQALVRAGSNHSSISCEEREPGSPQTSNITPNALGAVNVLCRARALVDCMPSPYDKDALAFKKGDIIDVLQMNNTGLWKGMVHNRLGHFKFINVEIINERFPRRGKWSQKYKQKPGSVPELLQRMNLQEYISVFLLNGYEDLELFRELEPADLDYLRIQHPEHRAKILTAVQLLHDLQSESDVDELAASSSENDEMAALGFNISRLGIGRKQSQRSENNLDAEPADSQPTEFQANLPLRLATNSTITRISTSVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU51</accession>
    <name>A0A232EU51_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_001486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002190">
        <property type="protein sequence ID" value="OXU21847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU51"/>
    <dbReference type="STRING" id="543379.A0A232EU51"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="259"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="554" mass="63002" checksum="E4AD2804FF41E1DD" modified="2017-10-25" version="1">MTKIVDLRPDKKLLNSKFEKYQFCSDTATPKCEKELKTEVLRLELNSSQDSWLEARLFAFHNHLFKNSYDSTCCFIDKNGGIWKFANDGSLDLIYTSKNIDSKSSDCLYNPSLAFASKNIIIICNGGGKLEFLIKKDESFNNFTFDIETAVVLDARFVKENSKIVVALYKIDEEKGKKFSRLIYLSYIYDENSEDQSQALKLLRTENLRVKGAVEHVYIEKNGYFSHIISQDHVEFDYDSLNPIKNKDEPNQSTNESQIKIPQYCWSQDEDSITVYTKISEKYSKVTAKVEATPTSLTISVGDVVLLSGETPHRLESDLTTWKRKEDTLEVELSKSENGLMWSELIKGDTGGEYLPNDALAAEIHSRLSHLCSSEQESNTQGQPAIGFNSEQLEECDLSGSENILQRIDLNAHNITHMAMLGSSNRVLFTEKQSSGQIICLRHDHDGCTWLMRESDGEDWDLEHIYTFPGFGYVEASKTNKKFCVSPPDGSYIAIIEHTRHAFLYEKPEKNATTGRQRILDFGSEMSPILGATTLKKYLIILTKDALYQLQVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU89</accession>
    <name>A0A232EU89_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002167">
        <property type="protein sequence ID" value="OXU21887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU89"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="8093" checksum="289CA87E69C683D6" modified="2017-10-25" version="1">MSRSLHVGRFQMYKICRNDNISTNLFSIIVKKTNEVVSINVSSIMKKCIMVALENDKWYVVPLVNNLETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUM9</accession>
    <name>A0A232EUM9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002113">
        <property type="protein sequence ID" value="OXU22044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUM9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="376" mass="41518" checksum="B7639C20FCDA010D" modified="2017-10-25" version="1">MSTSQKKQNYEVCGDCNLPIQIKDPKRCEMCTNYYHATCIKFRSLLVEGLQTFTCSICAEEYLRKKSGPLSNSLGTSTTVNSPTSMMNASLKAILSDIQKALKDIELKQDEALESHRQMTTRVAEIELRLGPIQTRLKAVDQLPQIVTRMTAAEATIAELQSQFSELTSKGSSTNQPSSQELSCSKATDPAEIAYLMGQLREIKKQQATSSTSNVAVLTGLQYGHDTALRLLVFAVLSALDPTVLRRDIISVRIMGRLDNRAADSKMPPLAVTLSSHALVYSSIASKIKRGKLHTSELSVETLREANANSPWHTTLLLKSVRESVLLFVIWDDIQLRHIILNVINKNCDRAFCTSREGKIAEHGEPLATAKLPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUS5</accession>
    <name>A0A232EUS5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002104">
        <property type="protein sequence ID" value="OXU22077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUS5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="31" mass="3683" checksum="AD658D597F712781" modified="2017-10-25" version="1">MKNKHDISYQQKALMSFITHDPVRYSTRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUY5</accession>
    <name>A0A232EUY5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002074">
        <property type="protein sequence ID" value="OXU22156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUY5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28146" checksum="4C345195EDD2B1E0" modified="2017-10-25" version="1">MDLRSLFTTDEELADLEDRDATTNIVGFIDTITAPHESGQNNDILFKFTVSNNNKRIEVLMWDTILIDKYQKDILSNRVININGAYCRATTKSKVKEEKNMVPFEIIIKENTVISFQGYHTLKNTSNIKLQKVTFDNIHAVEGLIEISGFIRTPFSLIHNRSGNMTYGLGAITDKARKITVQIKQFTASDLEIGDFVTVSGIVKDQDSLVTIYCDSMNNIKLDPDVESLTPEIVQRGGRPVKRIRTVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVU6</accession>
    <name>A0A232EVU6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_002850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001951">
        <property type="protein sequence ID" value="OXU22472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVU6"/>
    <dbReference type="STRING" id="543379.A0A232EVU6"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000028">
        <property type="entry name" value="Putative calcium-binding mitochondrial carrier protein scamc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000320">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU22472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="184" mass="21026" checksum="5D6C93D7C33EE5BD" modified="2017-10-25" version="1">MPSSNLARGAQMAGAAVTGTPPPAHYLHELPAQDEERLGTLFKKLDLDGNGRIDVHDLSKALHEAGVHERYAQKFLARSDQTKSGDISLAEFIHYVREHEKNLRLQFTDLDKNKDGKIDLEELIKAFKELGIEMERAEAKKLLQRMDKDGSLNISFNEWRDFLLYAPTTDIHELIQYWRHSTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVZ7</accession>
    <name>A0A232EVZ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001929">
        <property type="protein sequence ID" value="OXU22529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8192917at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="747"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="935"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1701"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1766"/>
            <end position="1779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1879" mass="215860" checksum="04AC325C52D27CC8" modified="2017-10-25" version="1">MVLSNQEVRLIIDNEQPSSDGSAITRFLNHSENLLSMYSSSLKDEINAQLVQHLVNNEIIRDVNKVFDNENPFLDLKTFEQQMKALHENSDYIDPIEIPLGRRVDSRLNKTTLSYVSKEVVESYQYIPVIKVLKMVLSNQEVRLIIDNEQPSSDGSLESFIDGNHFKNHVFFQKYKKALRLKLYYDEKELVGPLGSKTGVHKVGVFYYQISNLPAHMNSALNSIHVLIVAHHVDVQKYGFEKILSPFMKELAQLESDAGITLKFGDENFILRASIESFCGDALALHDQIYFVHCVCIIDKIYTIVAHHVDVQKYGFEKILSSFMKELAQLESDAGITLKFGDENFILRASIESFCGDALALHDVFNLLIRTKNVYNHHLELLKSTNFSDASKTATGMKECFKNLFPNVNIINKFHHAMHYSECVLWSGPLENNELAKRAQAVNNFKNIPKTIIRVSQCIQCEKWSSGNVKINHHEVVTGKTKFVCSTLTRQYLLRLGFEGNNSVCVTKSVLVNGVEFRPKLFVILEKASSRNDSLHLFVRIEEIIVTEDNKIFLLIIECHTVLXWLLTRALPFLLAGKIEEGDEHMYLIILLLRIMEIIFSPKLQKPLLSLYDNLLQEFVECFKNLFPNVNIINKFHHAMHYSECVLWSGPLVHFYCMRFEGKHNVLAKQAQAVNNFKNIPKTIIRVSQCIQCEKWSSGNIKINHHEVVTGKTKFVCSTLSRQYLLRLGFEECHTVLDDTDLLAWGFCIGRNDSPTRFLQVKDLPYYKPVCYRSKPNNEGISGKTFLDLTQADLKEMSIRMGSRKELLQVIKMYKDESNLLQPDIMEMFTLDVDGNTLIPLNKETDKQEHLENHECHTVLDDTDLLAWGFCIGRNDSPIRFLQVKDFPYYKPSKPNNEGISGKTFLDLTQADLKEMSIRMGQSNLLQSDIMEIFTLDVDGNTSIPLNKETDKQENLENHGISGKTFLDLTQADLKEMSIRMGSRKELLQVIKMYKDESNLLQPDIMEMFTLDVDGNTLIPLNKETDKQEHLENHDEGISGKTFLDLTQADLKEMSIRMGQSNLLQSDIMEIFTLDVDGNTSIPLNKETDKQENLENHGNGKRTLDETIQLSTIDNNTECSSIGIKRRKLASIPCSSTCLESAADKENHEKNNSEEKTTKSSSGSQKFTSAKPHEFMEHFYDPRTRYGFIPFRVAEVQKKLKAEDKKYVLKKKSKVLTTETSSNIAMLSPEELAEKEHFCDPRTRYGFITFRVAEVQKKLKAEDKKYVLKKKSKVLTTKTSSNIAMLSPEELSEKISYMEHKYPSPEHKESITATLKETFFNRRNWILGESPTIAEVLQKYPRLQDYNGDMIIAEFELMFPEKCDDFLSKFGPYYVPRIFEYTRICNYDLWKKHKAITDDVLKTLLLLITLLPVSNAVKNKSKKKVDKPMDSSQKKKVKMIEPYRFMIENINAGANVQEFVKSKRSECTSAIQPYIIQVDDETPXKISSPARLQWRYAQFLKNTFFQIIAEFELMFPEKCDDFLSKFGPYYVPRIFEYTRICNYDLWKKYKAITDVSNAVKNKSKKKVDKPMDSSQKKKVKMIEPYRFMIENINKKVDKPMDSSQKKKVKMIEPYRFMIENINAGANVQEFVKSKRSECTSAIQPYIIQVDDETPHFYYPVSLQNVYTFIESYVYRLIEKKSISIVASLYVNLKNMNLTHDSNSSDISNAVKNKSKKKVDKPMDSSQKKKVKMIEPYRFMIENINAVAVGTASGCEVTPSWGPEATEPPKRVKNNDRTSQKVSLRDVEGMLPRFSGKDPAYPVKAWTDSMDQLAVVYGCSALETLVAAKKSLDGTAKTWLQRHGHLASWDVFKTTIGDDFAEQTSSRAIHEMLEKTKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWD6</accession>
    <name>A0A232EWD6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016244</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001876">
        <property type="protein sequence ID" value="OXU22668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWD6"/>
    <dbReference type="STRING" id="543379.A0A232EWD6"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="13">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="14">
        <location>
            <begin position="121"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="12">
        <location>
            <begin position="226"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="15">
        <location>
            <begin position="460"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU22668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="613" mass="67933" checksum="CDA52A89CF89C0C1" modified="2017-10-25" version="1">MTLPKIANVEKEAKFGYVYAVSGPVVTAEKMSGSAMYELVRVGYDELVGEIIRLEGDMATIQVYEETSGVTVGDPVLRTGKPLSVELGPGILGSIFDGIQRPLKDINELTGSIYIPKGVNTPALSRTIAWEFNPLYIKNGSHITGGDMYGIVHENTLVKHKMILPPKAKGTVTYVAPAGNYTVEDVVLETEFDGEKTKYTMLQVWPVRQPRPVTEKLPANHPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQALSKYSNSDVIIYVGCGERGNEMSEVLRDFPELTVEIDGVTESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCLGNPDREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYLRALDDFYDKNFQEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKITLEVAKLLKDDFLQQNSYSPYDRFCPFYKTVGMLRNMIAFYDMARHAVESTAQSDNKITWNVIRDSMGNILYQLSSMKFKDPVKDGEAKIRTDFDQLHEDIQQAFRNLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXP2</accession>
    <name>A0A232EXP2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001719">
        <property type="protein sequence ID" value="OXU23132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXP2"/>
    <dbReference type="OrthoDB" id="8117927at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012918019" evidence="2">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="20659" checksum="CF8BE760B424BA0B" modified="2017-10-25" version="1" fragment="single">TLQLTLLGLLISAAVIGTADASPLARIHVKFVQPPHVQEYGLKTEGARVISQQSYLSIGRRQSPANLRTGSPVMGGYYYPRPRTIPRAFAPVEQNDINLSNREYSHRTPDFSNGLDYPDPLLLTGEAALRTVRYIYGRGELFFSDVPHMRAILRNQQERRENGLNGNILRSIRPNSPFYDHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY01</accession>
    <name>A0A232EY01_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001694">
        <property type="protein sequence ID" value="OXU23203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY01"/>
    <dbReference type="STRING" id="543379.A0A232EY01"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009449">
        <property type="term" value="P:gamma-aminobutyric acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF10">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61806" checksum="CF92B39D4DB7A0A4" modified="2017-10-25" version="1">MDNVNVQMIGTKITAIKEYLYNFARTHSPTRLMSSENTYSLSKEHGNLKYSDILPQNAEGFPATKEFLMKVVDILLDYIKTQSDRNSKVLEFHHPNEMLRLLDLEIPDTGVTLQQLLVDCSTTLKYQVKTGHPHFFNQLSCGLDLVSMAGEWLTATANTNMFTYEIAPVFILMEHVVLQKMREIIGWPNGAGDSILAPGGSISNLYAFLAARHKMFPQYKERGLAAVGGQLVMFTSDQCHYSVRSCASVGGLGTDNCVMVPSDERGRMIPQRLEELILERKAKGHIPFFVNATAGTTVIGAFDPIQEIADICQKYNCWLHVDAAWGGGLLLSKKYRHPRLTGIERADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQMSAEYLFMTDKLYDVKYDTGDKVIQCGRHNDIFKLWLQWRAKGSEGFEKHMDRLMELTEYMVRRIKQMPDKYYLILEPELVNCCFWYLPTRLRNVPHTADRERALGEICPILKNRMMESGTLMVGYQPDDRRPNFFRNIISSAAVTEADVDFLLAEMDRLGHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY07</accession>
    <name>A0A232EY07_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001692">
        <property type="protein sequence ID" value="OXU23205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EY07"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8145" checksum="D0A0A028F8512736" modified="2017-10-25" version="1">MAKEAFASRNYRLALEMYERCLKQQGPNFEVLFGYGDSLARCGRIRXXXXXXXXXPVRPRPARPGTRPTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ22</accession>
    <name>A0A232EZ22_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001558">
        <property type="protein sequence ID" value="OXU23605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ22"/>
    <dbReference type="SMR" id="A0A232EZ22"/>
    <dbReference type="STRING" id="543379.A0A232EZ22"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU23605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="13576" checksum="6950C69594C29458" modified="2017-10-25" version="1">MDGGGYSGDGDLGARSNDQPTVSNKKLQQTQAKVDEVVGIMRVNVDKVLERDQKLSELDNRADALQIGAAQFEQQAGKLKRKYWWKNLKMMIIIGVICAIILIIIIASTVSSSSSDDPPAGGNGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZF5</accession>
    <name>A0A232EZF5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="4 17">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_009082</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="17">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="17">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Peripheral membrane protein</topology>
            <orientation evidence="1 17">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4 17"/>
    <dbReference type="EMBL" id="NNAY01001525">
        <property type="protein sequence ID" value="OXU23687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZF5"/>
    <dbReference type="STRING" id="543379.A0A232EZF5"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="15 17" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="70"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU23687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="330" mass="38309" checksum="FA2B0F897284D3DB" modified="2017-10-25" version="1">MLQYIRILPSNKILWKWKSTATSIHLKTQYKAFSFTNKDGLRGNINTQISHLEQKSCANIFMIQKEPFIKIVKIYRWNPEKPTTKPYLQKFEVDLNKCGSMVLDILHYIKAELDPTLSFRRSCREGICGSCSVNINGINTLACITKVTRDQEKSLLIYPLPHTYTIRDLIPDMSHFLEQYKKIDPYLKRPEEHDFVGMRQLMQSERDRAKIDGLYECILCGCCSYACPPYWWAGEKYLGPAVLMQAYRWIIDSRDQTHEERLGKLRDFFSVFRCHTIFNCTKTCPKGLNPGRAIAELKRLVTGLTDKEKPDMETPVPSRCRGESVTTQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZY2</accession>
    <name>A0A232EZY2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001463">
        <property type="protein sequence ID" value="OXU23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZY2"/>
    <dbReference type="STRING" id="543379.A0A232EZY2"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="15225" checksum="3DE0817722DD56AD" modified="2017-10-25" version="1" fragment="single">YLCLQNAEAAEEAFTSFINQHPKIEKQPPFILPLLNFSFFLLKIIQFGKMSMFTILCDQYFTSLSRDPCFLQYLEKIGQIFFDVQPSQIYSRRGLFSSFLQSFFNDINEEENSDDQQHINLKSIITAEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F032</accession>
    <name>A0A232F032_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001440">
        <property type="protein sequence ID" value="OXU23972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F032"/>
    <dbReference type="OrthoDB" id="7699272at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF94">
        <property type="entry name" value="AT20289P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012195518" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="268"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="531" mass="58837" checksum="C22DDDDE1791BC7E" modified="2017-10-25" version="1">MCYAVYVLLLQCVLIYELSHAEPSVGVNVQQLKENKYPFVVSIGDNRDPDQIKHFCTGALISNRHVLTSEHCVEDLEYKDIHVLVGSFDLLEGRKIGVKSWLTYDDWADKNGYTSEFANNDIAVLTLSTEVEGINPAVLSNLKNFKLKNTEAIVAGWGVSNSGDIPRFMQTARVRVVPSTECIERIQKVQGKRIILPSKLYLCTAATPYALIQGGDSGGPLFNDKLEIIGVNDSSSPKRYRPEQQSDVMNVHVSVDYYRNDLSLADPLVGTNINQANAGQFPFVVSIGNNSETDQIKHICTGALISDRHVLTAEHCLEDDVGGLLDYNDHDLFVLAGTQDLLKGGRRVEIDSWITYKEWALKYGKELLRYISEEYDVAVLKLSSPVRGIKPGTLSALTEEQIVGTETILAGWGAINTNRVPRIMQTSRVTVVSSKKCQNNFHVFNPKAKLFDHVFMCTGSTPPTFLGDGDSGGPLMNDKLEIVAVNMATWPGRTETAGDHGYSVGQEDLVMNLHTRIEFFESFIEAAKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0L0</accession>
    <name>A0A232F0L0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001408">
        <property type="protein sequence ID" value="OXU24073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0L0"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371207" evidence="5">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="254" mass="29086" checksum="5FD53BE941551C1A" modified="2017-10-25" version="1">MAKFVLSCCLAVVLLVGAASCFEDSKVERREIGSANKSYDYFVFAQMWPQTTCWNENRQWTDSQDTCTRCRIPVDSWTIHGFWPSSRHGGHPSNCQGNAFQANALSSELREQLARKWPTYKNKVRLESFWGYEYKKHGSCALDNNSMDSVTKYFAKTLELLSKYDVGKALEKSNIRPGGQYNVREMAQALKRAFGKNTYLQCKTNPQTHEQYIVQAQVCFDKSFHLIDCSADKSRISNCSNKKDVIYPENLKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0P7</accession>
    <name>A0A232F0P7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_001325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001365">
        <property type="protein sequence ID" value="OXU24231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0P7"/>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="4">
        <location>
            <begin position="131"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="504" mass="55803" checksum="0FA47AB2B733D847" modified="2017-10-25" version="1">MALGVEASAEEDAVISVKHTIRDERTMDEPIGTMPDNAGRSRPPTPPPMPSTPRTVICRPCELRREKPTYLRDRGNMMTLSVRAAKCAALMTEPDELYPERILYPRNTRTLAKTPVTGGTPIDEETCMALRMLVFGSCASPPKTEWARTGLTLRPVGQNLSFGLRAPRNSTRGLITAVQAIMLKHFLFKLTKQEIRCSPDVLLKPSYEKQVEVLTASIAEIIWRCAGGFAVQNASASFNSATSSLNMPKAVVVLPQETPYLQHSVQYFQDGLTETLHLFEFTTLDDLEIFIKRYLYLFQDEGGPGAKLLLYSAILSRGLSKVRNDMEDPRASILGGCPEEGPLSLVVLAITGRASPHLHNGVIHVGDENTYAIPQWGVLVRSEIGFLVHEGDTTASKQPGSRLKTPSLPIWVTLCLGHHGVLFNTNRELLRNYHAERRFDLQYYTCGGSHATLTVDTRARENASGIEGSSARETMDIAATPLEKLIHSKRWQDAQIQWNGTPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0T9</accession>
    <name>A0A232F0T9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001345">
        <property type="protein sequence ID" value="OXU24294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0T9"/>
    <dbReference type="OrthoDB" id="10037961at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="12817" checksum="2ACA073168251CE5" modified="2017-10-25" version="1">MVQISKGQKEQDYVHPPAIPKTILNEIEDGFKKLSEPEFLRKCLGGQTQNANESFNNILWNISPKTGWKGLLFLMSNLDIVPGKNALSAAVIKGQLRIKEAEKQTEINSKKHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F173</accession>
    <name>A0A232F173_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001295">
        <property type="protein sequence ID" value="OXU24451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F173"/>
    <dbReference type="STRING" id="543379.A0A232F173"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000664">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="422" mass="45471" checksum="09ACA0260C5EC9B1" modified="2017-10-25" version="1">MGIEGPKSPTPSRRRSSSIAVARPTPDLHRFLQAEAGPWGHLSPSPRSPTRTPALSPGAVSQTSQHLSPGASPGGPSPTSPGGPAAAGGSSRLPPQSRHRGRTSSMPAVPRHRPMLAETRRGGVGNNGGHGDDDTEDGVEYYRLRSFSITANGVFNLGDSLKSRRSRSINSVTSSGTSCSSSRDARLLSSASQLSGIETGADGEHQAEDGGSRVASYKVGMLGASGVGKTALTAQFTTSEYICAYDASLDDEYGQKSVSVMIDGQETELEIIDHPATEMSVEAFCSTYNVDVYVVVYSVVDRRSLKFAEETLLHLWKSDYMAGHGVILVGNKVDLERKREVPAMMGRRLANSCGCKFIETSSGLAHHVDELLVGILAQIKLNPQRDRDQVTRRRRSKQRRKILKHLLGFKRKTKSCENLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F292</accession>
    <name>A0A232F292_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001259">
        <property type="protein sequence ID" value="OXU24588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F292"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="55"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="237" mass="27819" checksum="A140574DD727AC3F" modified="2017-10-25" version="1">MYPEMCFYYPENKEVYNIFKDVIAIPSISSGICAVALMNENTATHKFMLTFTKIVRMLLCMSNLRQPQRSDRRILFVVLIYLTIVLNSYFQSRLSAMHIVPNSDPTIDSREDMENSNLLVYGKQDYKEDCINKSPGMHVSNYVIKEIFEVMYTRRDWPLRFKFDKIIHYLHQAGIIQFHENMDNQVFAKHEPKHEQYSHLTIKRLGVAFYVLISGFVVDLRFGGGTSRFTNSDIDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2F9</accession>
    <name>A0A232F2F9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001222">
        <property type="protein sequence ID" value="OXU24689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2F9"/>
    <dbReference type="STRING" id="543379.A0A232F2F9"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="645" mass="73514" checksum="967E8C5DF2FAE3D3" modified="2017-10-25" version="1">MAEGSNAQIIAIPDDVCRKAGTAATWVGPNKLALFGYKHVNVHSKDAPSSFSPCEAKVHFLRPEVILFSPSLRKLVNESNGVFLSIQKLNCSPTSNDSRPEMLKYSKQYRSILRACIEELQDLAEKCPQEKKNLYENFQTIFYNIECVWHLTEILYVDVIPGDVVLPQLLEWVRFHFPSREIMAMKILAKKKIGADLENNEYWEAVMGCALHGKLDIVRALLALHSKADHSAFIAAENSLRNMPVYNVYGGYSVKEFTIRWKQWQMSLSQSIDSKAFGVEENLEALMRLVVGNEFWEFSKYTEAWYELLAAKLFYSAPCCKQPELARHANSVAIKWQSNRQTSLITLDNIILALMESDLHQVIKEIQYMNDNGWFAAHLTDLLYHCGRLNIMDKHQINVTDLLHESLILDYGSTLMDHHSLWQCGASYLEHCPTQGLARLETLLQTIPLGSEARIHKIIDLANEKNMHNVVNSICKIQGIKCINQGRLGNALAWALKARDILFASHIADRFLKHYVEHAEIQCRDLLENLGPCMLVSDRLTFLGKYCEFHQMYGIGEFKEAARLLISLIVSELTPNYFWSMLLTDAIPLLETDDLVFSSEDTFELLHAIEEHGDDPKFEDKVMIFRLAAARNLARALIIEGSMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2M2</accession>
    <name>A0A232F2M2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_015668</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001156">
        <property type="protein sequence ID" value="OXU24945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2M2"/>
    <dbReference type="STRING" id="543379.A0A232F2M2"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000037">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU24945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="307" mass="34413" checksum="D2BC3F42DB0DF665" modified="2017-10-25" version="1">MSSQQSPAALQATIDREKVYNWIIELSNPETRQNALLELSKKREVVPDLAPMLWHSFGTVASLLQEIINIYPAINPATLTAHQSNRVCNALALLQCFASHPDTRSAFLQAHIPLFLYPFLHTVNKTRPFEYLRLTSLGVIGALVKTDEQEVVTFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDSGLSYICQTYDRFSHVAMILGKMVLSLAKEPSARLLKHVIRCYLRLSDNPRALLALRQCLPDQLRDNTFTTCLQEDVSTEHWLNQLLKNLETGPPQGPPTQPGQPDPRTIGMSPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2M9</accession>
    <name>A0A232F2M9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_013127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001206">
        <property type="protein sequence ID" value="OXU24738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2M9"/>
    <dbReference type="STRING" id="543379.A0A232F2M9"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="151"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="324" mass="37175" checksum="6F2DF89D5F18A634" modified="2017-10-25" version="1">MDNKKYKIEYPNNSLIILEAILVFDEWLLMKARWLLINFFQIVVPILKFCFILLMGAGLLMAYCLANAKFAIPDHSRYFNCKNSKLSDKYLQLNDDSMPSAMSVRKELIQIKNMKMSIKKSLLKMNFHLQHLYDQQKLANLADFASEAVGGIVIDTPGTQSYYNPSSNQMTLFGIPIFKPNYFTPRKVIQPWTQAGECWAFRGSQGKIEIQLAYAVIIERVTLEHITATASLTGNIDSAPKAFNVLGQIDNQYVMIDTFVYKNNGQSLQSFAVTKPETKSFPFKKVILEILSNWGNPDYTCIYRFKVHGKMYDVFKEEANMKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F346</accession>
    <name>A0A232F346_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001167">
        <property type="protein sequence ID" value="OXU24910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F346"/>
    <dbReference type="STRING" id="543379.A0A232F346"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="494" mass="56997" checksum="86D8C80FF4310DB7" modified="2017-10-25" version="1">MPIPPDVVKCYKHIDTCSKNYVNELKQIVKIPNVSSDPDAKNHLSTLIKWISSRMKKLGFNILLKQPYHETYKGHIPLVVVGSLGNDTKKKTLLYYCHLDVLKVQKGQWITDPFELTEKDGKLYGRGTAKMKGPLLCFIHAIECHRELGIELPVNIKIICESMYECKSKGLRSILEDLKATFLPNIDCVLLTESHWLGKDYPCIVYGMRGVCYFNLTVEGPRMDLSSGDFGGVIREPMQDLLFILNSLIDPFGRINIPHFYDDVVKVTPDEEEFYKKIKIDIEEYRNNVSVNRLGHDEKLKTVLMHVWRYPWFNMHYINTSCEGSNLLDIPKKVVARFSIRTVPNQKHEKVSTQMINYVKELIKRSKTPNRIDINAEHALDPWYENHLHWNYEAANKATKQVYKEEASFIREGNGFPTLLKIRDALPKRNILILPIVDCEAKAHSEEENISLRCYIEGTKLLVSYFHELASTARQHSSSKGSSLGRRDVCRDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3F3</accession>
    <name>A0A232F3F3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001064">
        <property type="protein sequence ID" value="OXU25271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F3F3"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353269" description="Superoxide dismutase copper/zinc binding domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="686"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1348" mass="151723" checksum="7BE391724037810C" modified="2017-10-25" version="1">MANNRLWFLPLLLLVTCVATGNAVRLAAYISSGGLHGEIRFEPANNNNVRIRLALKTTLQYPDQQWHWYLTEFPVDYTLIENRCDSRNLGKSVVDLTELVGPLDFPGNETGSIEVSGLSLSGEKGLWGKGILMRDTYSNRVICASVTVLDRNTEKLAEARFNGDIAGSVWMRWLGGSASEDSTDTIIHTNLQHTSNRNFLNESFSEHHWKIYVTDIFDTGKERTSCSILQTVFDPDNSGSGKSIGDIDARLGKIRVASRVNSNFRQAYRDPGLAILPADLIGPHHVLYLVIFHPTHNDIILGCAKIKPRKAITAKAIVDSRGIKGEVTLIQETPFDPTWVNVSLSPINDLETRIRYETKVVSYSIHELPKEPEKLLQDTIEPCLTTKNLYDPLKINENTVPPAGLGTQDQYAVGDLTGKLQGRKEGSHHLDILPGSAKLSGLYWDAYLPLSGINSVVHRSLVIHKYNESDNDATSVIPWVCSTFSLQLPNNAGQMPMITAEVTFRYPIVGKVIFRQPRNEPEMDTTIIIEHLIHADGSSLNDSVDHRWMIHDEPPGQDYYNWTSRCLSAGAPYNPYKIEWDDKQPQFCSEHTVPFCRMGDFTRHGNLNIAGRKKDGLRLTRKLFTDTLLTLSGPTAIFGKSLVIYDDHGPKARGERLACSIITGLYRRKAVAKDWFGNGEEISLGGKLEFIQESAYDVTDVEVNLEGLDGKMSGYHVHMTPVEIDLTFPCEGTSLYGHWNPLNVDPSTSPPSTSGTSDQYEMGDLSGKFGTLDGRRRYMSVYNDTQLPLFGPRSILGRSIIVHKKEKNARWACTTIERGYAPSEARELRAIASFHHPQGYAYGYIRMTQLIYKDGSQSDTVMEVKLRHPGRQDRNVTRNHNWAIYVNPVGVDATVQIKDTRCVAGGYRWNPYFTQLADPLNEDLYRQECGPDLPLRCDVGDVSARVGPIDIGVERRVFSDPNFPLEGKVTALGKSIVILDKDFGSSRFACANIEPDNDIVKYANIRKPPRFVAAQFLEDVRQVMGIPEWMLSIDNRKTKILHDGACIQFLLHFKGPIANKLEQDFSKLMTTGRLDAPSLPIPGYVPTKRKNTLGHRQCGTRDYSDKTQPKTVEEHFKLIMTDGSYIDTANKKVNFNDLPDWFDEELFKKFYKSVNVIRWKHSMNSKRAIDNGLTGISQRDMVLTQFGFVGYVLTHPDVMGLSDTTEERQAINHLWRVVGHLLGIPERLNLCRRNEYETTLLCNMLLDALYIKNLKEPTQEFHTLTIAAVKGIGSIDPLVDLDAFLSFFYEINGIKYEKKISAFSRFNYLFRKANFYVIGFTGICTFDVSTGCIKNFPFSAISDTENKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3L5</accession>
    <name>A0A232F3L5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_008836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001112">
        <property type="protein sequence ID" value="OXU25099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3L5"/>
    <dbReference type="STRING" id="543379.A0A232F3L5"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="7">
        <location>
            <begin position="173"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="307" mass="35041" checksum="AEDB958DBF9A63FE" modified="2017-10-25" version="1">MFDPKITKKKKKKKTGFDLDSAIADQSNEATENSNPDKENVDVDAAAPEDEESLDLENFGKKKRKKKKFNLEELDAALPETKKEDVAEPQAEEQEIEDFDLSLDFSKNLKKKKKKKKDLDELMAEEKKESEANDNEEPSQWVGSDRDYTYDELLARVFNIMKEKNPDMVAGKKQKFVMRPPQVVRIGTKKTSFSNFTEICKTLHRQPKHLLDFLLAELGTSGSVDGNSQLIIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLFFLQCETCGSRCSVASIKSGFQAVTGKRAAIRAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5G7</accession>
    <name>A0A232F5G7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta'-coat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_004244</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000931">
        <property type="protein sequence ID" value="OXU25852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5G7"/>
    <dbReference type="STRING" id="543379.A0A232F5G7"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000008">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="319"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="588"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="880"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="880"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU25852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="927" mass="104643" checksum="A1CAA82469AC1BFB" modified="2017-10-25" version="1" fragment="single">PLRLDIKRKLTARSDRVKCVDLHPTEPWMLCSLYQGNVNIWNHESQTLVKTFEVCDLPVRSAKFVPRKNWVVTGSDDMQIRVFNYNTLERVHSFEAHSDYVRCIAVHPTQPFILTSSDDMLIKLWNWEKSWLCQQVFEGHTHYVMQIVFNPKDNNTFASASLDRTVKVWQLGSSTANFTLEGHEKGVNCVDYYHGGEKPYLISGADDRYVKIWDYQNKTCVQTLEGHTQNITAVCFHPELPIVLTGSEDDTVRIWHAGTYRLESPLNYGFERVWTIACMKGSNNVAIGYDEGSVLVKVGREEPAVSMDSSGGKIVWAKHSEIQQVNLKALGEEAQDGEKLPLVVKDMGACEIYPQTIQHNPNGRFLVVCGDGEYIIYTSMALRNKAFGQAFEFVWAADSSQYAVRESSTTVKVFKNFKEKKSFKPDFGADSIFGGYLLGIYSSSGLSFYDWDTLKLVRRIDIQPTHVYWAENASLVALATADQYFILKYRAEAVQNAPENAEDIEDAFEMVAEMSEVVKTGLWVGDCFIYTNSVNRINYFVGGEVVTISHLDRPMYLLGYVPKDNRLYLCDKELSVVSYSLLLSVLEYQTAVMRKDFDTANKVLPTVPKEHRTRVAHFLEKQGFKKQALAVSTDPEHRFELALSLEDLETAHELAKEANSQQKWRQLASLATQQGELDLVQECLHKAEDAAGLLLLATSTGDAEMVEKLAVSCDESGKNNISFLSYFLLGDVDKCLDILIKTDRIPEAAFFARTYAPSKISPIVKLWKEKLSAVSEKAGQSLADPEQYENLFPGYRESLEIEKHMREEYKKKIPAHEYRNITPKIERNAREEMLAAQGASTSQPPDELKERKPVGDDVATVTQRLMDVDINKSMQAPIAPTAAPAKPTGAHNTSSTSRPLTVDDEDLDLDLDIDDNIDTSLNTRIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F679</accession>
    <name>A0A232F679_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_003471</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000818">
        <property type="protein sequence ID" value="OXU26344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F679"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902850">
        <property type="term" value="P:microtubule cytoskeleton organization involved in mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000996">
        <property type="entry name" value="Cytoplasmic dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="1046"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="1327"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="1644"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2184"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2417"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2745"/>
            <end position="2779"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="3561" mass="397643" checksum="1A6576C46B429453" modified="2017-10-25" version="1" fragment="single">VANFHNTIGDRMIPSQRPLMLATALELAGAVREQSGVAWSDPRAVDVFTNRLRELVKKFARQNSELAAKHAALRDLVCSLLKGDAINLVANQNTWKDTLRSMRDIVGSVEVDYGNTKVWKLHWDRQLLKALGIAYRAALPQLLKKLPEIRVELTFRDESLQWRPSLEDIRMKLYSGIRRFLAIPTNFRGVGDQVDGHFQTLIPRSAYLFGALYKEAEILLNALESLRVKWLPLVAPAKIDIGETLKGKQPQDWEKAFKDAKQWAQEVGKLRANEVKISCIVVDTGTIRNDLESLSRRYWERLALDLRAEASSRLVSIVDFLFSASKKLSHRARTIEEIGEAYEAYSHIQTQSDEIAKELEDVSGLGRILAAWTREKLDGLSNAHTAWDSLKERLDNYHGVMLHQLEEAKLNLRHQVLAVHDEQERWNAKWSTRPEVITRDWIELMREKWTNLTEQRDTLVSDCKRLNLPVDEIFESDERMIAQIEAELEAEELNSKFQNEFIEELQRHEEEEWSVARRRLHKLHDWLDSWESRIQLQSRSQLEDQPSLQEETAKLQANSFIGRKITELREAVDCAQLLRGDELAEEHWNELKEIIELTRIKRMNEITLGHLLQKAGLIKANAERIKDVTKRAAAESGIRQAITELEAWESYTSLPLQESRDSKNEGVYIIGDYSTLLARAGELRLILEGAKGAAGYERFASRAARCEASLYELEERIKVLSVVQRKWIYLDPVYGSGAAPSDSGRWARADKEFRYLMGEIARDPKIPSLKNLPFHALANLKDLMDRCQRSLDDFLEEKRSAYPRLYFLSDEDLLELVSGKGKGLDVHLSKLYQGVGSVEKENGCITSVVSPEGERLKLSERVSLSESFPRWLLTLEEGIRNALQQSLNTCLLEQTPDIAAYPTQILLLCERIRFTEKCEMAIDDDTVGLKNLLKFLENQRTRYRGLEDPDDALKSLKAKNLLLETVHHLHIVRNLLDVVAEKEKLAWNWSRQLRTYKSGGGAIIRCAKAEFPYRFEYQGAAVGLVRTALTEKCYLALTQAMKLGLGGSPTGPAGTGKTESVKALGSILGRRVLVFNCDEGMDSGSMRRILSGLAQAGAWGCFDEFNRLEEGTMSAVAMLIRPLQEAVRDGASKANLGGLEIPVDPHCCLFITMNPAGDDYGGRRKLPDSLARLFRPIGMAHPNKANIVKSLLECAGFTNASTLADQLVETFDTAEKLLSKQPHYDWGLRALRSVLSAIPASSDEINENTRMLAAIQSSTMPKLIDKDASKFLTLLNDIFPSASSASSGVVIKEKENLQSILSEFCVSQGLHDSLISRCVQLHDQLQTRSGAAIVGPPGSGKSLIIRSLAEALSRTGEPVKLFSIYPGAISKSKLLGSVDPQTREFKEGLLSSAISNCGSQPLWIILNGDVEPEWAEALNSALDDNRILTLPNGVGIKLGYETRFIFESHKLSGASPATVSRLGIVYLGTVSAATLLKAPLMKDLPSVASNIVASHLCSLIDQVLKVKKDQKSASGLLHSALVHFRYAHTQASCTYALLNSMCGQIEDATSREDLARSIYQLTGIYCPDSGAPYDVLYNKQKDALDQFTIDARTIETEDGSVYLSGLQGLHSYTISCVICGKCTMKRVSGSMQRGMNASSPWIISGQAVIFRGPTGCGKNAMLSAILTLVKNESGESFMMVKASSLYGSKDLITRLKRSCIKLDSSAGGRTYKPKNGSKLILVVEDLHLASKSLQELIRQLIQEGGFYEDDLEFAKIPLTIVSTGDASTKLHPRLDSLLASHYVPSLKAKELDSIVELHLRESLKSDEIMIKAWITKMSPTIVEAFNEITADKTSVKWTPRDLMMWIDSLKYYPKPENEAQITSYLIDASRRLFRPKLLLKQQRRLESTVYSRSSAAPTTGDNVYVWNRTNSGLALLSESHWKSELENAVTKCIREGDTMSTTVSSYLLEISAGISWGLGCEQRGILLTGRPGAGRKSATKIVSVISSLRLVDSGPGKGKSAVKAAVQAAGIDGEPTILLLEEHHLREEGFAVLASAIIFNGELPGLYTTEELDGLVAPLADLAAREEFSGNLEQYLYHRLRKHLKVALIVDANDLKEPWLSRSNLLRHCVQTTGQSLGSEWWLMEGPLTELASLYRDPSKDVDEEFSGVKEVIQAHLNASSSQQAPARFLALLHKWKELREQWLEEILSKLKNLNAGIERLKEAGDRVAKLEEDVTKQRRELEVERGRANAALEQITATMRGATGQRGEMAALKTETERESAELARRKADIEGELGKVEPLVEQASQAVAGISSDALSEVRSLRAPPAPVRDVLEGVLRLMGIRDTSWNSMKTFLAKRGIKEEIRNWDARRSTAASLEAVSKLVKERPESFEEKTAKRASVAAAPLAAWVLANLQYGQILQQVAPLEREQRVLADRLAAAEAQIGKLESGLNSVESKVAQLQEELAAHSRGAAELQLRTEATESSLATARALLGKLDAEHADWQTQSQMLSKRKNRIGIEAANAAALLVYQNPPKNDEKRKQVVDLLISERDRLQWRGQGLPVDTESFVGAARSVRGNLVPLFLDPSGVAVNWLRTHVGETRLETTRPGDSRFLTSVELAVRFGKPLLVEEIVQLPAILLPLLRKRPLRIGDRSLPAQLGFQLFLATRQESLAEELPSEADATLVKISLGSGSRSLAERLVEKAILQETPEVEVRRREALEREEKLSGEIESARLDLLVQLGAARGQDILQEAQSQQGGGLLATLELTQSKAKEIARALEESRRDLEDINKRSKEHERLAKFTAILYKFVRSFAALSSLYVFTAEAITEIFLEAEKLRNGVHSASRDEREKVLEKSVITLTLHHCTKAVYRKHRLPLALHLAMSLSSVPEEQRGLLLSGESAYISGNSDLDAPSYVPAEQKSAMVQKLKQSWVSNIVSIYAEESMSHFEKILVIQALHPEHLHTALSKWAAQQLGVKNLTPPSWTLKQIAEENEKRPVLLLLSPGADPEPELSGLVANQMVTATGFNEVSLGQGHVAQAEAALETACKQGSWLLLSNLQLALNWLPRLEAILRSPSCTTNRNPNTRIWMTTEECSGFYTGLSGLCLKLAYEPPEGVKRNVKRSLQQLQQRQPAIPDPCKSLLISWLHAILQERRKFVPQGWIKAYSWSEADLEAACELVVRRNPRDSLKKTEDWEADRGILDVAVYGGLLQDEYDMRMLRAILRQVWSKDTYTGRRKLGGAVSVPKANSENPIYMIDRLDDADSLQVYFGLPANAHRAWEKSAAELTLRYLNDILRKNAKVRKDNADGRMSSSVLKIVKDLKLIIDQQRIDDPRSGKKENREFRDDPLKRFFVDEVTTTRQLLRLVRYDLDSLRSADDLKTPAKWISEWQSGPREILPFVNRLIARYQSLASLSGLPNKVELCWFARPDAFLSALKQYTARESGRPFENLRLRTKWTEDSDSRDGGWKTAVYVEGLLLTGARIENGILEEVTANASSVVTAPPCLIAFVDDTANNSSGEKQAGTEWRDADMELTTDYCALQVPVYTDSFRSHLICSLPVPYVKEQRDVWHQRGISFHLRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6Z7</accession>
    <name>A0A232F6Z7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_006259</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000772">
        <property type="protein sequence ID" value="OXU26601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6Z7"/>
    <dbReference type="STRING" id="543379.A0A232F6Z7"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14338">
        <property type="entry name" value="UBA_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="29"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="17">
        <location>
            <begin position="886"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="506"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="605"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU26601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="935" mass="102190" checksum="5FD4C33DE9648D2B" modified="2017-10-25" version="1">MASASSTAGNQPQQQQQFPVNKLIRVGYYELEKTIGKGNFAVVKMATHVVTKSKVAIKIIDKTKLNEENLAKIFREVHIMKRLRHPHIIRLYQVMETEKMIYLVTEYAPGGEIFDHLVRNGRMVEPEARRIFRQIVQAVRYLHQQRVVHRDLKAENLLLDADNNIKLADFGFSNEFKPGVPLSTWCGSPPYAAPEIFEGRQYDGPRADVWSLGVVLYVLVCGVLPFDGPTMQSLRSVVISGKFRIPFFMSAECEWLIRHMLVVEPERRLSISQILSHQWMFGEGGQPTEAESESISPNGDSLVPQQLNQLVIESMLKLPGLDIDTLLQAVQGNAFNHVSAIYNLLCDQLENAVTSVPSIQNVPGGYVPDDAHQLEKFGETEGVEMEERSGLQLPIGTPYHATRRHTVGPGDTAHQPANAAYPCGYPMGYAPLHLLPNLQLNADPQLLPHTNLALNLPLVQNQPPQNFQIKDQHLLKPPSAMGATSSFGRRASDGGANLHVFYQQQHGSNSGEEGSWSQPGSREHLQPPGSPALSPCSPSLSSGTNGGDSSAGSSSSSGSDRRRRSGLTTVMQRPVLNPEVVVEVEKRMNRCYLPPRLLPNHLKGAGGPTMPHHRKTSIYPTSTAGPRDSYKEPSVHVTNAERYSPVRRASEGSGPQGPNIQALQQEYQQLQKLASPLHSPASIPGSPVHERGIAAITQGLSGLSTAPVQGSIVHGTPTQQSATPLDLSPLRHHRSPATTPVSYSPSNSPALDMIQEEHPVDVLRVPPPPQISVTDVLGGQVTLVGCSPSPSPSPDSLEDILPHYSPLPSFIISEPCDPLRPSITRGIGRPLSGTPVPTEVEVTLSDESSRLNSEAILGRVKQIIDARAPPKGFIFSRQEMDGSGLSLEYPGGVQIELRVCESEEKESKGIKMRRISGDQLQYSQLCQQLISCITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F849</accession>
    <name>A0A232F849_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000716">
        <property type="protein sequence ID" value="OXU26835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F849"/>
    <dbReference type="OrthoDB" id="7701229at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="670" mass="72439" checksum="FD3324014612ECAC" modified="2017-10-25" version="1">MPQNTLKYQLGGCKEIFQRTRYPNFDQNDKTAIEMATRFSILLVCALLAVAAQAVPLNTADAQTCAELCSSCKGVASFDGDRCECNIEGHTNEEVECVSRMKRQAEERGLNLLSCDLSSDKRSTRCTLGLKHKLGRNNIDQVAKYFMQDGPITGNIFRAPPLMGKSSDCVGAARIVTQPAETYELRPVQPQYIAIQRNYMDTQPLVSNPEPQQFVSSPNSDCVGAQQMVSSPTPKQYSAPKEVVSSPPQGQKLSSPKSDDTVGDIHKIITQPQETMPEEKEESTPQVSQKSYSDCGPAVGQAASGVGAVDPLKILGVPSITPTLLQILGQQLSHPMLGIPQAIQTISKTPGLNDLVSAPGHLLTGIAHRLGLPAQTLRTASDAPKFSDDDNVGMPKMEDSKPSGDCGSTLGSENPASNMPTISYLNPGYGTQYISLFNPTVGAPWNPTVGAAAPGQISYMNPTVGAPAPTHISYVHQLPAYTAIPMIPSTMMSSYVPQMPATTYIVGSPMSMPFYNTASSPMGMQQSDTTLEETFKYEPDQHVGKAKSAETPALKQQKKICKKSNQEEAARKITRDVKGFPASITDEELEKQSKMIEAANKQAKQNTTELPKIDRTTTQRPAIEKSSGPKTKVERSAARTDKAKSEMIGKIKPAKEITKKLKGDKKLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8L6</accession>
    <name>A0A232F8L6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000649">
        <property type="protein sequence ID" value="OXU27184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8L6"/>
    <dbReference type="STRING" id="543379.A0A232F8L6"/>
    <dbReference type="OrthoDB" id="8188202at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="686" mass="79051" checksum="8C7C5E15D9C64B83" modified="2017-10-25" version="1">MLPNPHLESNWFDLQIQRASDQIQTIKQIKSIENPTTTGIMNVQDVTYQYHNFMKDHSQTSISEQYYDKKPDKCLSEIDLPSNLMEISKDLQIYADNSYVPYNQNRVSAFQEKYENNSTNINKHSKSNIKIAKCSTKIGKAVSHPHLLYRDQSNNTNKSLTVMNYQNKTFVTDVTTNNDKCKMFMKEMQIERIQKKNVASENIDLCTPESSLEISTSVKQMSLDERLELEKAKKTLPENCEDNCETISTKSQKDSYMEHTNKIIQNCGQDEQKSFFVTDTSEFAKKAQQTDVTKKRTLYNKFTNFKNYDKIKLNADQFKVHQQDADSDYEKTEQCSSIIDSGRGSVACSSEKKCSAEEFDCLKGQDAEWIDIVESELSNILGPNNIPTINRSNFSDSVSSVTPPLPPVTPPENSRVAHNKFGNSLDYSENLYYDDYIRNLETQHHRNVIKKRDITGYKKKEINNYKDRMEAGYLTSTTTGLDLDSMLDRSDSDFSINDARTIKKQLDGLEYMYSEVLKLLGNGSKQRRKKRGMASYGSVSSLPTSSVSSRPLTKHYDKKKSHFIEDRTKKTEHVKNINKRFQRLESHVVTLARSVAHLSSEMRTQHLMIQEMENIRGEISNLRTQTNMAMIRSQSQPVLKDSDLPALSNPSRVKKLTKFFGVEPPLLRLFLRELGYEFMQQIRKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F971</accession>
    <name>A0A232F971_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000613">
        <property type="protein sequence ID" value="OXU27401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F971"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="21099" checksum="5E72DAF1D3098DEB" modified="2017-10-25" version="1" fragment="single">IETIRAAAVSATTTAYNFARRSCRKVLASKESETRRAERSRETIINIFYVHAWHLTAASARARVIYLCVRTNARRERERERRVARKIFPYGNVTMYKIGLRLDSRVTFIPRRQMYSYMKRFAPARARAHMLLQSAERAEKAIPFYPSTQHRDITHPHPSTYTQTHCKYIYIYLKVDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9C0</accession>
    <name>A0A232F9C0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000678">
        <property type="protein sequence ID" value="OXU27033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9C0"/>
    <dbReference type="OrthoDB" id="7554657at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012104650" evidence="2">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="316" mass="34867" checksum="34114288BF7EB238" modified="2017-10-25" version="1">MATKLFVLGTILLIGIATESSAQYWNRQYSYSNGRYPQQVYPGYQQQRPNYQQSNGWQNAGSFQLPPGVSVADAEWICKSPKTGDMMIIATEDGPAPNTGGNSQGQWQQPSYPKQPSNPQPTLPQVNPSQPTYPQMIIASEDGPVPNRVNGQQQWHQVYPQQPGNNQPNYPQPQQPVYPQPQQPAYPQTQAPPVTNAPTTTTEDTNRPIWGSGGNDNRYPQTQAPVTVKPTTTTTEDTNRPIWGDNNKQPNFPEVKPSFPTSTTQKPVDPLWPEGGSSNKPGFTVIEPTRKPKPHKTTKAPIDDDDDDGPLDIVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9G6</accession>
    <name>A0A232F9G6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000665">
        <property type="protein sequence ID" value="OXU27110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9G6"/>
    <dbReference type="STRING" id="543379.A0A232F9G6"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000110">
        <property type="entry name" value="methyltransferase-like protein 13 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF78">
        <property type="entry name" value="EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="664" mass="75299" checksum="F0B7D4FCB66937C1" modified="2017-10-25" version="1">MNLLPKSHQEFSKADYWNTFFKKRGKKAFEWYGEFPELSSYLLKYIKPKDEILIVGCGNSTLGMDLYDAGYKNVVNIDVSQVVIKQMQDLNRVKRPNLVFEQMDATKMTYDDGKFSVVLDKGTLDALMPDSEEATMTLITKYLEETKRVLRNSGRYICISLLQEHILRTLVTSFSSTFAFRAVRCHDAEIKAKEKDESPMPVFMAVATKFIKLPQPILEIVLTDGPPMRLSNVDEIVNNVISTQESASLCNSLYKSSVANDGEVSLDLYKPGDKDPRYTIYILDQLMVKERKSYAAFIVPQGREMDWLFSTKEGRQQLLKSAQHDRLAIVILRRGQIFESLEAVKNELGDSIKNFAPAGLSKSQIPFLSLGSDIGQRKIIYEGKSDFSGQFVVEEIETESGLYRRLVFLNNQFVIQSEAKLKQVTSRRKKTKYIVDPHYVACDHHLYMSVGLKTALKNKSNGEAVIIGLGGGGLCTFIQQYIPQTTITAVEIDPAILKIATDHFDLVQDEKLKVDIADGIEYLIHSSKQGKKFDTILFDVDSKDSSVGMSCPPKQFVEPDFLKTVDSCLSDEGLFILNLVARNKKLRDETVDDLKKIYKFVASYKTEEDVNEIIFCSKNSKDFKEWKDSMQESAKALNELAKTKNNTDELIELSTLLSSFKIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9L2</accession>
    <name>A0A232F9L2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit Tim23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000619">
        <property type="protein sequence ID" value="OXU27365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9L2"/>
    <dbReference type="STRING" id="543379.A0A232F9L2"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21869" checksum="95874DC93A717989" modified="2017-10-25" version="1">MIDLRSENASSSPISNSRQRDNTSTSVASQPGLSSLSPYLNYDPVYFPPSQPEFIFPEGAVKQRGRFELAFSQIGAACIIGAGIGGATGFYRGLRSTTLAGQTGKLRRTQMINHVMKHGSSLANTFGVVSLMYSGFGVLFSWARGEDDSFNTLAAATATGMLFKSTAGLRKCAVGGGIGLGLAAAYCLWNSKDVFEIRHHRMNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9N7</accession>
    <name>A0A232F9N7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000626">
        <property type="protein sequence ID" value="OXU27322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9N7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="71" mass="8244" checksum="A5DFD4E71900E2D8" modified="2017-10-25" version="1">MSVYREKPTRNTGDGISFLLFPSVRAVFGRFLPEPPPGESLSFFLPPLAFRINYIRLDIFCFYCLFPVCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9V9</accession>
    <name>A0A232F9V9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000667">
        <property type="protein sequence ID" value="OXU27097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9V9"/>
    <dbReference type="STRING" id="543379.A0A232F9V9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="610" mass="66877" checksum="972BD8F03CA8C616" modified="2017-10-25" version="1">MSCNCPLTTAVGPTLASTCGGPSFMLFMGLLEVFLRSQCDLEDPCNRPIPQKRVNSRYDFVVIGGGSGGATVASRLSEEKRFSVLLLEAGLDEPTGTQIPSFFFNFLGSDIDWKYSTESEDEACLNKEDRKCYWPRGKVLGGTSVMNGMTYMRGSRKDYDDWARLGNPGWSYDDVLPYFIKSEDNLQVNDMDYGYHGVGGPLTVTQFPYHPPLSHALLQAGKEMAAIILKNIPGYPTVDLNGRTHTGFAIAQTTSRNGSRLSTARAFLRPARNRRNLHIMLNSTATRILFDRSKKAVGVEFVHDGQLHRVSVDKEVIVSGGAVNSPQILLNSGVGPREELEAVGVPVVHDLPGVGRNLHNHAAYAIAFTINDTDTTPLNWATAMEYLLFRDGLMSGTGISEVTAMINTKYADTSEDHPDIQLIFGGYLADCSETGMVGEKKGSNRVILIIPTILHPKSRGYLRLRSNDPLAKPMIYAKYLTHPDDVGALIEGIKFSVALTETEALKKYGFTLDRTPVKNCEHLKFGCDAYWECAIKHDTAPENHQAGSCMMGPADDPMAVVDHQLRVRGVLGVRVADTSVMPRVTSGNTNAPAIMIGERAADFVKRTWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA69</accession>
    <name>A0A232FA69_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000647">
        <property type="protein sequence ID" value="OXU27207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA69"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="160" mass="18619" checksum="EF78CE95566CFDBD" modified="2017-10-25" version="1">MYVSGLRIYDLFIYSPVTNGSCLIQCEHFYFNYYLPAVRDKMRKSLTSVQNTSSKEVQNVHCQVQMYVSGLTICDLFIYSSVTNGSCLIQVHRNETFLENIIYKCEHFYFNYYLSAVRDKMRKSLTSVQNTSSKEVQNVHVINNDIRSFTGKDISNIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAJ4</accession>
    <name>A0A232FAJ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000601">
        <property type="protein sequence ID" value="OXU27453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAJ4"/>
    <dbReference type="STRING" id="543379.A0A232FAJ4"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="286" mass="32765" checksum="C8FC92A9BAC7EBDF" modified="2017-10-25" version="1">MFTFNFSKNNSSQENETDKNGDKTNQLNWLPAKEIEIPQQYFKKNHESIHYVTNSAIPDFTLKLVDSDKVVIKLTEENCENIIEAESQHSDLLPAKYEGGLKIWECTYDLANYLLTENISLRDKAVLDLGCGSGIIGLVAFLRGSTVHFQDYNSEVIESVTIPNVILNCDERDAVKERCKFFCGDWESFANLLTKGNDDLKYDFIFTSETIYNPDNHHKLYEVFKQKLSINGFGFIAGKTYYFGVGGGMRQFEELILKDGIFDVKVVWKSDEGLQREVLKLERKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAQ3</accession>
    <name>A0A232FAQ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000590">
        <property type="protein sequence ID" value="OXU27518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAQ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="39" mass="4704" checksum="A0E64C8161687A9D" modified="2017-10-25" version="1">MNQTKKKLSNCRRALVVVLWDSKIIVKRTRFFFLYACLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB61</accession>
    <name>A0A232FB61_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000481">
        <property type="protein sequence ID" value="OXU28076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB61"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012398583" evidence="1">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="18437" checksum="D2D855C36D18A8B1" modified="2017-10-25" version="1" fragment="single">ICLQNLVLAVTLSLAGFAAADLQNIQNANPLNIDLSDPSQTQLATNDADDPKFGGYRPLYPPYFLRESTNVGEQQPNDQTYYDKEYYTRGTQHDKRLDRNLRIVPQQQQQQVASATPTVTIVRPSSGFARAFPNFNHQIKSFASSSSSSSHVASSYSFSSVRFPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBK8</accession>
    <name>A0A232FBK8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Gamma-tubulin complex component 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000552">
        <property type="protein sequence ID" value="OXU27717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FBK8"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="386"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="843"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1243"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="684"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1664" mass="191649" checksum="09A2EECA561C7F83" modified="2017-10-25" version="1">MRGEMEPEPQDNDVYGLVRGLCENLFRKHHQAEEHPYLPQQDNEKHLRRFKAKAYEILLNKSGQDYAKHREPCDPIVELLKHAYVLKVGVGRVSQAAELEKYLDEFIGSHLEPDSVVYRTLQFLNCLKSVDFEDETSLDIFYYGRPHPSLPEMLYDEGGIPPFQVYPCEAFHLPKKFETMFKQEQGGVIRYNAAEPGSKLALLNRFTSPNSHVQNTRHNYHFDTKMSNIPRRTTQLLNGTDVTLSSYFIPQIKDVCSSEDQFQVCKEGIVTEPESPWQCPDPLQWFAEQNRAAADNPTEIREIEDNDADEELAKLDKVWEQMDKFSSLSSHRTWETLGSSDPSKEPPFVSESVEATLHLVNVAQSDLFPDQIVQVSRGEFISNMKLLLLGVESTMFMFNPATGFELKKNLAVQGVSARSLENLSYEVCRWGTCFRNLSDLTVPDSRSGKLRVEGLIFKALCSSIKEFLLFYHAAILKVSLTDASSDAGLLSFLNKVRPLGGLILRVAELCRCDSNRASPLGEGIGILTHIYKEVTKVTEQRVALVFYSILRECCEVYFRFLQHWIFEGVCADIYEEFMIRVRPQYLRTQGHRFWTRAFSINRASVPGFLSRLTDTILQCGKAVTLLKICDPQNPVCRVSASSQPRVKVCLSVGMLREQARFYEAYEARGEHEQGEEVSLSSAIRDEKEAERRRAELVIAAQQDTLQRLRREREDALRKISKEKSDLLEQLKDQAEEAAQRRIRDRDKELMEDKLLLEDAMKMDEEAKNAERIERESTIKYYEELAEEAKRHRIHADWRIRRMKLFDERVAAIASMRREFINTPEEPKDFLAAEKDEVDPAEGIVVSQPISDKPVAQEQVLSEDENSNPTSVKLDDPPVQKNKVKSMVKKLNAMSKAEDRKNQNVVEPAQTTSKPVRPTVLDISSPHRKLSMELTDNLSAAQRNKLKVLQSEFGIITPNNNAPATILRAMENEESRTELTETQMNRLRNTKHLTNLNWENIEGNENLKKHLESAEIQEGDQTEIQLNRLRNTQHLTHLNWENIESIENLKKHLESGEIQQGDQTEIQLNRLRNTQHLTHLNWENIEENENLKKHDLGEIPEGDKTEIQMNRLRNTQHLTHLNWNDVEGNEQNINLATDDNTPLTDAQINRNRVMSHFYSRMDELEEHIGQPKSENLTACQKNRNRNMAHNTDQFDFEINRFTEREQQQHHLKETPMSTNTDHFTISTHSGSGQVHSCGNTPFSEITNHSDMLRSTDGMSTDETSQRSRGSRYFQETPAYPEFIGLGSAANTPSIENQQQQLTVDDVEMIDSTSLQVYLEKSVIIPLRVQSRLVNNAIIKVELGNTKRTFSLPIYLLNEHKMLSHLHSLRSYFFLLNGEFAKTLTQSLFRRLYEVSSPLELFNSSTLSNFLEKALVSSLSGSYANSELLSLSAADVPTYLQTSNPEILSCLSLNYKISWPLNIVFNDVVMQQYSRVFKFLLMVGRVLWVLQEDFQILKIERKAAITENHHKLQLYRHSMMQFMNALHTYLTCSVLHASWSEFERELESATTLDEVYETHVSYIKKILSRCMLNVRGEKMRTCLCNIFMVVLKFHNRIRAQDWSGAHPSSTGPNYENLEKMYVTFCEQRTYLAHVAEKLANSGYQPHLMQFLHALNINHRYDLASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC95</accession>
    <name>A0A232FC95_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000483">
        <property type="protein sequence ID" value="OXU28069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC95"/>
    <dbReference type="STRING" id="543379.A0A232FC95"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU28069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="272" mass="31585" checksum="99E753093A18BE66" modified="2017-10-25" version="1">MSLGKLFSHVKFYLKYALYYSYCGIVSSILLPYALLHPMDVLNHLLFARMSMPLIPVLGLSYEIRGQEHLALDRACIIVANHQSAFDFMGTIRVWPIMRKCALVAKKLLFYGWPTGLSAWLSGTIFIDKKNWHKYGRILEDAIRTYKEQKVKVWIFPEGTRYHEGGIHEFKRGAFYMAIKFQLPILPVVYSEYYFLSIKEKRFDSAALNRVDSFEGKIIMKALPAIPTEGLELEDVPELMAKTRLLMTETYDSLNEELRASLRLQESHRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCQ5</accession>
    <name>A0A232FCQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peregrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_009487</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000455">
        <property type="protein sequence ID" value="OXU28273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCQ5"/>
    <dbReference type="STRING" id="543379.A0A232FCQ5"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15670">
        <property type="entry name" value="ePHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15572">
        <property type="entry name" value="PHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05839">
        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="559"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="15">
        <location>
            <begin position="865"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="661"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="754"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU28273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="988" mass="109529" checksum="E343A898258296BF" modified="2017-10-25" version="1">MRNSTAPHSSKKKGRNRSKIGKLAEAQATSPNAAGSADATPVQESNNYGNKNLNPLREDGNKPFKVNFNDSIPILSQEEFDADEKNTSFKSNSSAAADREKEDKAILSSLPTAVAKELDGYESQIGEAEPLPNSYVRFMERSGEELDGEVEYDLDEEDSAWLSIVNERRAASGLTPNLEPDTFELLMDRLEKESYFQQQSNGGGAAGALVTAADEDAVCCICMDGECQNSNAILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNRGGAFKQTDRPATWAHVVCALWIPEVRFANTVFLEPIDSIESIPAARWRLTCCVCKRRGVGACIQCHKSNCYAAFHVTCAQQAGLCMRMRTVQPANGEPMLVQKTAYCETHAPPDYQPSTNPADARRRAIANKKSSSAPVISIPTIPPERIREIANLADGLPKKNQLIQRLIAYWTLKRQYRNGVPLLRRLQSTHPHPRAPPSLGDASSPTPDAEIRNEMYKQLKYWQCLRQDLERARLLCELVRKREKLKKELFKVKEKCMWFELRPLESVLRVLLETLKLRDPNDVFGQPVNIEEVPDYLDIVTHPMDLSTMEAKIDRSEYDSISAFEADFNLMVNNCLAYNRKDTMFYRAGVKMREQGGVLIEQARKDYPELDGGHITEESAEEAEAESEEPQQHVNSTPAAGGAKSRKRDRSARVRNDSESKANNEKDTSSTSIMSTSPGGTSAANISGSSTGGGAISGGVNRRTAVLFTRKAKARASRGQLHRTSPENEQKKQSDSFRVYRSGATDSDIGERESQSSSCSSCSTSRSTSPERDDDLDADGDDTAHEDSPTHKPKSAKHTNDDVSANEANSKMETDSNGALTALQLVWAKCRGYPWYPALIIDPNTPRGTVHKGVPIPSPPDDVLALASNYKDRVYLVLFFDTKRTWQWLPGEKLEPLGVSQELDDGKLIESRKPTDRKAVKKAYQDALLYQKQTRNSTLSVSAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD00</accession>
    <name>A0A232FD00_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000440">
        <property type="protein sequence ID" value="OXU28380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FD00"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1508" mass="175229" checksum="891CCDC2D3D16B32" modified="2017-10-25" version="1">MELHKHFMSIAELESSIFEIIGSTPILQESIDVIASKYIEDCFEALKSTGTSKKKLELLRFLLCQQYKLNYEHPRESKAKFQTKLNHFLEFLLNSKLYTQKENQSILNDVMVLQVVLFEDQKYFVKFFEDFRASCTADRTETANKLSIGWYLKMLNCFLSAWEVLNFLNDKLNVGAANKAHLECCKKVLLSSVMYDLQTWIQCNENNELRALHLLLSKVVTIAKNNRILSPYLHEILDKQFALTIICILCDFVFPIETSNMDVDYSLIHHANLWCMVQNKLVSEILQERKQALYLFKRLIDFIDLNEEKIKKTISLNLMPNKINPFICTENESSKLGIKLIRTNFVLIMEALEEKQKHLVIPSLSLVDSLIEGYREHVSCGNCFDFGWLYCIFARILKHDNNAVVKWGLLKSLKLNREVYYYDHFILLVVKTLNNTFLYEKNYEEVQPEIVTALTTWFNQFQSECLRLMEKFIVTFYESSWAPVPLFYILQSLSSTSDKLNNIVDLQYEELDVLRIVLDRNIKLHPPMLRTMSQVLLIKILSRFSQNPKLMDITKLLSVFSKRDIIEPCSWHALTSWLAKSQYNDTISFINQVCDELMFDDNTVGIKMSTFSIIIQALFEGGIICQSEQCSITQKLTTLFLCLDKIDIRPYVKVSLVVKIIDLFTNWFNLQHEVPAFVYKILINYKQTIFKFILKLFHNEDFDSDDILIFTMFLQNIEYFSNGKLNTICIVDSSNRKELATKCLQVLSNTNKHNKVQLLFALETLSNISNHYKYDNKLLLENIKDLIQTCKSQERSNEMTGEIASNYYFALSKLIKNHVKTLNFDDLMANDEWLKILSLVVDTAGNQVLIHFCDVIYQVSSAVVNDSEKLEELTVLTKSLWNCNFGSRRDKVFWLVSQKLTKCINSSNFLNSPCLKDVSEEFTSRMLSEGESLPVLKYILLIFSEIKQNFSYFIDIVLNGLLHGQVMRRDQRINMQTFVEAKKYLKAYTLKDETIDSLEVYEFINRQCNIDAAIRAAAVLQLIKALQNDNKNAALLLPLILKKLLAIQKKRYFADSQLHRLKHRLMQILLILQPYLDQQSTVMLYHTLRDSIVYDSDQHSVRLMKEWLLVRIYLSNRELLSDLWSFFEKICNERPGSASSIIGIIWHISLQLDRNHVSEFIKKALEKLGVCCMGQQFGIRLFGQVFFIKLYELLDENSDLRQEYANFHKSVLASLNCGNFKKNPIKIDEDFFYSTFNPIQHYTLETIYHQLPRLSNVSNEEWITKENFEEQLLLDNGTINFDIKNTDCSLNAASIPYSILKSNENYKPEEVECSENITDMQKKITPWKTMLPNEEELSEIADLSNYRKECNNKQDIVVVASLIEKSQNLGGIARTCEIFGVKQLVVSNLKQIEDKEFQVLSVSADKWIKIIEVKSFSLANYLLELKDCGWTLIGAEQTANSVNLYDLKYPKQTVLVLGNEKNGIPANIIPLLDMCVEISQFGVIRSLNVHVTSAICIWEYVKQYQFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDQ3</accession>
    <name>A0A232FDQ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000399">
        <property type="protein sequence ID" value="OXU28650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDQ3"/>
    <dbReference type="SMR" id="A0A232FDQ3"/>
    <dbReference type="STRING" id="543379.A0A232FDQ3"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="221" mass="24418" checksum="EB0A556139C33291" modified="2017-10-25" version="1">MNRLFGRAKPKEPPPSINDCIAGVDSRADSAEKKIARLDAELKKFKDQMAKMRDGPAKNAVKAKAMRVLKQRKMYENQVDNLRQQAFNMEQANYATQTLKDTQATVVAMKDGVKQMQKEFKNINIDHIEDIQDDLADMLEQADEVQEAMGRSYGMPEIDDDELAAELDALGDDLALDTDTSYLDDAIKAPSAPDKEPGAASVTNKDGVLVDEFGLPQIPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE96</accession>
    <name>A0A232FE96_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_004271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000337">
        <property type="protein sequence ID" value="OXU29104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE96"/>
    <dbReference type="STRING" id="543379.A0A232FE96"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000182">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000411">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001071">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="9">
        <location>
            <begin position="184"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="389"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="791"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="802"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU29104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="100190" checksum="BB1999546EE38F0A" modified="2017-10-25" version="1">MLLANKIQDKMEPEPHYVFHNEEDLLYEEEILRNAYSVKHWWRYIDHLRTTQSPNLNVVYERALKELPGSYKLWYAYLRHRVKQLVGRPINDPLYEVVNNAFERALVFMHKMPRIWMDYCTLMTEQGYITQTRHIFDRALRALPITQHHRIWPLYIDFVKRHNVHEMAVRVFRRYLKLAPEETEEYIDYLISIERLDEAAMKLAYIVNQDDFVSKHGKSKHQLWNELCDLISKNPTKIKSLNVDAIIRGGLRRYTDQAGPLWNALADYYVRSGLFERARDIYEEAIQTVTTVRDFSQVFDAYAQFEELSLKKRMEEAAENPTEDDDIDLELRLARFENLMERRLLLLNSVSLRQNPHNVLDWHKRVELYEGQPHEIINTYTEAVQTIQPQLAVGKLHSLWVAFAKFYEKNEQISDARTVFEKAVMVPYLKVDDLASVWCEWAEMEIRHGFYKEALRLMHRATAMPSRKVAYHDESETVQKRVYKNLKVWSMYADLEESFGTFKTCKAVYDKIIELKIATPQIIINYGLFLEENNYFEEAFRAYEKGISLFKWPNVFDIWNTYLTKFLKRYGGTKLERTRDLFEQCLEHCPPKHAKALYLLYAKLEEEHGLARHAMSVYERATGAVLPEERFEMFNIYIKKAADIYGVPKTRQIYEKAIEVLSEENTREMCLRFAEMEKKLGEVDRARAIYAHCSQICDPRITNNFWQTWKDFEVSHGNEDTMREMLRIKRSVQAMYNTQINMMAAQMLNNQTNDSMDAMKLLDNRASESALANDVIRPSQTINFVRGATEGGKGASKVVNPDEIDIDMDVDDEDGEENDNDSEGGEMEEDVPIEKQIIPSEVFGSLKNEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEV2</accession>
    <name>A0A232FEV2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_005337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000324">
        <property type="protein sequence ID" value="OXU29212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEV2"/>
    <dbReference type="STRING" id="543379.A0A232FEV2"/>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13582">
        <property type="entry name" value="Reprolysin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013302846" description="Peptidase M12B domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="239"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="593" mass="67594" checksum="E255B85613BD9DA4" modified="2017-10-25" version="1">MFLLFLSFVILAVSSHGSKIHEQMTAEEVHSIFRTTHDEVPEYEVVPIAHAIHENSPKDSIHRILQIKSFKRDMRLYLEPTEGILAASDLPMWTAEGDEDSPWGIKYTKISKGMKERMYFYQDPYNLAAFTSTHDEHGEILFDGTIGDDFVVRPLPARLRKVFSRAKRSIHEEDFPQFNRTVYHPNLKDTYHHVIYKKKEVSFDGIREKIGSYVLKNKTESESSRTKRSTKKTYNPKIVYPQILVIVDYNEYFRSLHNFAEVKRYIISFWNAVDLRYRVFVNPEVRLNIAGIIVATDPDGTPYTQNHRTRPVDGPIIDADKALDNMAEYFFEELMNKDLDRFAIDRDYDMVMLMTQLDLCNLEPNDHDFDCTTLGYAVRGGACTVNIRETKMEAVGLVEDNGGYVGIIPAAHEVGHLLGAPHDGHEQEDKTTCPAYGGYIMTGMLMLTKNVFMWSSCSMEYFEDFFHSQRAQCLVDTPRKVKASPRHLPGQILSVDEQCDRIKGTYACNKDETACVHLDCFVPDSGGQCLPVAPAAEGSSCGKGRYCINGQCVRRNTSEVLLQFAPPPEEERPYSNNIGVDVGLNIPFNIERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFF2</accession>
    <name>A0A232FFF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_007486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000320">
        <property type="protein sequence ID" value="OXU29250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFF2"/>
    <dbReference type="STRING" id="543379.A0A232FFF2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="63"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="412"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="680" mass="75837" checksum="BBB6251739AC8A9E" modified="2017-10-25" version="1" fragment="single">YCSSINYLPGISRHASLDLLLLHNARDSFLVYCCGLIMALVCTRASAATKIIKLSSGHDMPVVGLGTWQIKPDDVDRAVTAALENGYKHIDTAFVYYNEEAIGKSLKKYFDNGGKREDLFITTKLPSFGNRADDVEPMLKSSLEKLGLQYVDMYLIHFAAGFKRDPSKLEPAKDKDGNLIVDLDTDHLAIWKAMEAQVKAGRAKSIGLSNFNVAQIENIMKNAEIKPSNLQVELQAYNQQKQLRETCAKHNIAVTSYSTLGSPGSDADKKTNATLALPKILDHPVVQKIAKNHNKSTAQVLLRHVVQNGMIVIPKSTNPERIKQNIDIFDFELTADEMKELNDLDRGEEGRIFDFSIFKGEGPSSVSFRQNQLMRAFLGIVCLVVLAVLLPGGQAVEKLKLSSGHEIPAVGLGTSTIKLDEMDKAISSALENGYRHIDTAFSYDNEAAIGKILKKWFDKGGKREDIFITSKLPSQGNRPESVEKYLKRSLKDLGLDYVDMYLIHTPFAVKEGENLSSKQDKDGNDLFDDVNHKALWKAMERQVKEGRAKSIGLSNFNQSQVLNVYNNAEIKPSNLQVETHAYLQQKELRKFCKEHNIVMTAYAPLGSHSARLNLHRGTPKELPALVELPLIKSLAAKYNKSPGQILLRHTIQEGLVAIPKSSNAQRQNLDKNPEYPWHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFP4</accession>
    <name>A0A232FFP4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000271">
        <property type="protein sequence ID" value="OXU29581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFP4"/>
    <dbReference type="STRING" id="543379.A0A232FFP4"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000203">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="38"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="416"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="735" mass="85132" checksum="BF5862FAFD8D81F4" modified="2017-10-25" version="1">MNFSFRKPTPSSNWLALAKKLEYVQQYNFPYIDDVSKFSEMFIIGEGTFGRVFKARNKHTEKFVALKLIMVLNEEGFPITAIREIKILQRLDHVNIVHLIEICKSRGEQVVGFTIFVFRNTYMLNAVHKEKVKIPLYSAASPENYFKANFFLVMEFCEHDLAAFLLNKNVTLKLEELKMMLKMMLNGLFYLHSNKILHRDLKPANILLTKTGILKLADFGLARPFSTSTAAKRNCMTGKVVTLWYRAPEIHLGDRDYGPPIDMWSVGCIMAELWTRRPLMIAESEQMHLQMISGLCGSINTEVWPDVNKLPLFKVVKLPQHCDRKICKLLRHRINNDKALDLLDKLLILDPKKRIDANNALDHDFLWTNPLPCDLSPLMSQYDRTTPSPRSLANQDPNQKYGQEYNFPFVEGINTYRDIVKIGEGTFGEVFKARNKYTQQIVAMKMIRVNRATKDLSIMAIREIAILQRVHHENMIRLIEICKYHADFFLIMDFCDHDLAAFLSNKNVTFKLEEIKTMLKMLLNGLFYLHFNKVLHRDLKPANILLTRTGILKLADFGLARPFSTSTAAKRNCMSSRVATLWYRAPELLLGDRNYGPPIDMWSVGCIMAEFWIRHPLMPGTSEQGQLNMITRLCGSINRIVWPDVTRLPLFNVVKLPQCGYDWKVYADLWYCVNNNEAFHLLFQLLCLDPSKRISAYTALYHCFFRTNPLPCDLGAMMSRYNDRPNLTFFVNRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG26</accession>
    <name>A0A232FG26_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000248">
        <property type="protein sequence ID" value="OXU29716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG26"/>
    <dbReference type="STRING" id="543379.A0A232FG26"/>
    <dbReference type="OrthoDB" id="7610695at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="14882" checksum="0CBBC47E87500AA0" modified="2017-10-25" version="1">MTSTQQWTKWTKRTRNISTKGPNQPASPLALSQPRHTTLCKSKIDEVTGNSKEEAGGMQEGGSRVSKRAKPLDPEEEDYYYEDEVDERNNPTNEAPVVPPGFLSPSVREYLDLGKSIPGEKLELQQQQGSTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGW0</accession>
    <name>A0A232FGW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_007865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000255">
        <property type="protein sequence ID" value="OXU29679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGW0"/>
    <dbReference type="STRING" id="543379.A0A232FGW0"/>
    <dbReference type="OrthoDB" id="9836210at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU29679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45638" checksum="63AAAD2C2B98B62A" modified="2017-10-25" version="1">MSYISILPRRSSQSVNNEIARFFLRRPQNWETRFGCWAAMSLTVLEVKRLLLLTLEMLVNSRAIRFAGALMPIIFAFVDVGLGFPAAVAAVYAIRKHKVRPCQPKIKRALRRVLLSLTVCSILNVATVALIGLYVNGNASLIEKMFRASMKAYAKNAYYKVSIDELQLDLQCCGFSSYSDWFAIDWQLDYDDSDEGEPVNEQSVPFSCCNRRAMMPCIHMEMGASDERTVNARGCADIISRILFKIALVGYTMTGLIVSTQILMIVFFVRIIQRVLPEICPSDCSCWESTCQLKAPIINYSSDDCTSASPEKHVPEKRQSRNVVKWKTSSRCFSSSDSDSETSSCERLTSSPSFSELADRRVGLASIEPSAQQQHRLPAPAQCRNNSKAKNARKRRRKNSMTKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHM6</accession>
    <name>A0A232FHM6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_008296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000216">
        <property type="protein sequence ID" value="OXU29959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHM6"/>
    <dbReference type="STRING" id="543379.A0A232FHM6"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28041" checksum="33C987B888CDE79C" modified="2017-10-25" version="1">MRRCSQISFTRCCIVRYDHEGIGLSRSRHVNVNFVTITENLFFAIFGQKDTDDFTIALRENTQPGWTLFLFKITFSVYMLVTVIVLINLLIAMMSDTYQTIQAQSDIEWKYGLSKLIRNMQKTTMAPVPLNLITSWALHLHKTCKTRQETKKRMSVMNGFIGRRLPKSPFAQDNKLQPMSSARDGLGISLLQPSPLGSQLSFRNAPNINTIVDWDVVRHKYRVRFGGEVEKPASSSPLIFGSEIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHV7</accession>
    <name>A0A232FHV7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor AP-2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000221">
        <property type="protein sequence ID" value="OXU29917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHV7"/>
    <dbReference type="STRING" id="543379.A0A232FHV7"/>
    <dbReference type="OrthoDB" id="6252992at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU29917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="188" mass="20961" checksum="CAC4DC580181CCEF" modified="2017-10-25" version="1" fragment="single">AKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEAIHLARDFGYVCETEFPAKQVAEYLSRQHCEPQDSYRRKELLHATKQITKELMDLLNQDRSPLCNTRPQHILDPSIQRHLTHFSLISHGFGSPAIVAALTAIQKFLSESLNHLEKMYPGNGSGVTSSQQSSLDVKNKDGSLMNDMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ51</accession>
    <name>A0A232FJ51_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein max</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myc-associated factor X</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013558</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000155">
        <property type="protein sequence ID" value="OXU30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ51"/>
    <dbReference type="STRING" id="543379.A0A232FJ51"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11406">
        <property type="entry name" value="bHLHzip_Max"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000023">
        <property type="entry name" value="MAX isoform 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002418">
        <property type="entry name" value="Tscrpt_reg_Myc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00044">
        <property type="entry name" value="LEUZIPPRMYC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="186" mass="21463" checksum="1B908047A3BED030" modified="2017-10-25" version="1">MSDDDRDIDIESDEGDDSDSRQRHSNNQQYFSQAEKRAHHNALERKRRDHIKDSFSSLRDSVPSLQNEKVASRAQILKKAAEYIQFMRRKNTSHQQDIDDLKRQNSLLESQSESLYKYLQHTALFHEVRTLEKAKITGNFAAESCEVSKSDSIGMGNYNETESESSDSDTGRTIRHSKKLKTNSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ63</accession>
    <name>A0A232FJ63_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000120">
        <property type="protein sequence ID" value="OXU30784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ63"/>
    <dbReference type="STRING" id="543379.A0A232FJ63"/>
    <dbReference type="OrthoDB" id="9991832at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000270">
        <property type="entry name" value="Blast:Tyrosine-protein kinase Src-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000222">
        <property type="entry name" value="SH3 domain-containing protein Dlish"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043539">
        <property type="entry name" value="Grb2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46037">
        <property type="entry name" value="PROTEIN ENHANCER OF SEVENLESS 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="67"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="216"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="326"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="392" mass="43434" checksum="6114790F8BB58FF0" modified="2017-10-25" version="1">MAFLCPVRIRRGKKKKPGTHNFTLEKDGLGPGMGLSSRLPLPPGRITGSASIETLVRVGIEKENGLSPDSKMVIIHDFTPCVDDELQVKRGQVVNILYRENDWVYVIAADTRMEGFVPHSYCAPYTSQLAETTLALMNNVKKKLPRSMDDTDLVSSGRSGGMDNVHTDTGSASDCESYARNITTADINVNQSISQSQNSIQTTQSQPDVHPFFKDPSAGRYIVLYTFVARDENDVSVERGEFVTVLNRDDPDWFWVLRHCDGNEGFVPSGFVYPGHVLHSYATTGTTTTTTTTVSGEPHNLGAGNGNAMSNEQLQQKDTRDFRDETTGTELVVLYDYKAQAPDDLSVRRADWIYADLGNQTVDGWLWAYAPKTRKYGFIPKAYARPPAMTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKC3</accession>
    <name>A0A232FKC3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein VAC14 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000078">
        <property type="protein sequence ID" value="OXU31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKC3"/>
    <dbReference type="STRING" id="543379.A0A232FKC3"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="9">
        <location>
            <begin position="450"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="695" mass="78770" checksum="F9BA0443D6DFE5AB" modified="2017-10-25" version="1">MSDKDYAPLSAACVKSLNDKMYEKRKAAAHEIEKMVKEFAAHNNTVQIKRLLKVLGQDFVLSHNPHSRKGGLIGLAAIAVGLGSANTGKYTEDLIHPILACFNDADSRVRYYACESLYNVVKVARGAILPLFTDIFGVLSKLACDTEQTVKTATELLDRLMKDIVTESGLFDLVSFIPILRERIYTKNPFARQFIVSWISVLDAVPDIDLVEFLPDILDGLFKILEDPIPEIKKSADTVFAEFLHSIKANPSKVDFPGMMNILILHAQSPDEILQLTAIMWIDEFVRLSGPQLLPYTSGIFTAILPCLSYEGDTRKTIKDTASRVNNSLLKLLISKDEETSAADNLDLASIIEVLTKHLMLQQIPVQTKVAVLKWIYHLFTNLPDKMHLHIEELFPVLMKVLSDNSEEVVQQTLVVMAELIGTKPADGGENKYFTKFMVNLLRVFSSDRHLLEDRGAFIIRELCVLLNSEKIFKVLAEILLEEQNLRFSCIMVQSLNTILLTSSELFELRNKLKDMKTDESVEVFLGLYKSWCHNPVATVALCLLTQNYDHACDLVKAFGNIEVTVEFLVEIDKLIQLIESPIFTYLRLELLERERNESLVRTLYGLLMILPQSEAFSLLLRRLSAIPPSSMNTSVSKSEHSQTQTTSSESKRNKINFKELFEYFNNIQDKHKEQKHKQKQILLTNTNELTHSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKG6</accession>
    <name>A0A232FKG6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GGA protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000075">
        <property type="protein sequence ID" value="OXU31231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKG6"/>
    <dbReference type="STRING" id="543379.A0A232FKG6"/>
    <dbReference type="OrthoDB" id="447025at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027422">
        <property type="entry name" value="GGA1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041198">
        <property type="entry name" value="GGA_N-GAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45905:SF1">
        <property type="entry name" value="GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18308">
        <property type="entry name" value="GGA_N-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="299"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="8">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU31231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="428" mass="48980" checksum="E7EF6A3CA67F8323" modified="2017-10-25" version="1" fragment="single">MSRKKRRRLLGQVSKYQEIRSSPSKELRAKSQERFIAAGDVTRRTRNLKDVQEEKNIFEKKKKFCLEEEEKLCEEKCCRRKKFCRRGGKREEQVGGHVTLDGWPDDAIKELRNTAFVNVVKLMEQEDVEDVQGVLARDGRKELVTKNNIVVTLIPAREVGVMNGDVEVVDFAEPKVNLATLDEVSDSTDRGLAASEKTILEGRAIFGSTLAIIRDTRRRITDRLRAVNDVTVLQRAISKIEKILNEGIDNQLEKKKIVKSTITGRVLKEDLGDQSEKKEVIGSMIKSGREDTFEPLRELLDTCMQRCGPLFVSEVGKFRFLNEMIKLVSPKYLGTKTSISVRDKQWIISFPRETKIKEAYDMLKKQGVIKDDHCNFINCSGILNQSNKIKNPIFDDEEKAKLLQNLLKSKNPSDLHAANRLIKTMVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKX9</accession>
    <name>A0A232FKX9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000075">
        <property type="protein sequence ID" value="OXU31243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKX9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="10098" checksum="4822D71875A65ACA" modified="2017-10-25" version="1" fragment="single">SAFNCDITQLSAKNRSECSDLWVSTPRVRERRLQGVRVDPLWRVLIGLLRSLSSKFHNCVNRYRDFKNPGADPRSAFLRSDLLTGGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLF2</accession>
    <name>A0A232FLF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000067">
        <property type="protein sequence ID" value="OXU31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLF2"/>
    <dbReference type="STRING" id="543379.A0A232FLF2"/>
    <dbReference type="OrthoDB" id="9942861at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF15">
        <property type="entry name" value="PROTEIN-ASSOCIATING WITH THE CARBOXYL-TERMINAL DOMAIN OF EZRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70298" checksum="C0CD3E226415513A" modified="2017-10-25" version="1">MGNEKSSLSGLEIDDKAVEITDFWTHHSSNIHGSNPQNLSVFISEPSLHSDCSFGKPSPLEKAAKNLMLHRHPCILKYVSSWSKGSKFFLATEEVKPLVQVIGSQTTLQICVGLYSVLRALLFLHENASGSHNNVCSSSIYITSEGCWKLGGLEYFCRKSELNVAYFRKIKTYRYENAISPDEDTLMQSISDDPSAIDKYAFAVLAEEVLKLKDEDDVPGLAEFRELCKQKLDDVTLSSLTNHPFFTHDFMKIYAFLTELPLKSESEKEKFFLNLVSQLQNFPEKIVAEQLGKLLLSRMVLLDSTAQSKLLPFILKPKEKDDDSGLLSVSTFQACLVPKLLQMFCVRDAPIRLLLLTHLNSFMKTFQIDDLKHRILPELLVGIKDTDDCLVSTTLRALADLVPILGAATVIGGNRGKLFTDGRPNKVQRIKKIHHVTFGTPSETINTLNVPIAPDIPAALYLPERPSPDGGEDKTEVNHSFPEEENWSDWEGQENETSIVQNGKLEDAPDTIVIEEEFATIPLSLPTSSAVKNYKKKPIISDISELDIKHSKSMSEPVEEIDFFTDMEPVIQKTQVLHVEEISTTTTEMETKSIFNVNLAPVATEDGDDAGDGWGDDDLDDWDVESPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLU7</accession>
    <name>A0A232FLU7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_017004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000055">
        <property type="protein sequence ID" value="OXU31480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLU7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15772" checksum="37618E4A2C62AB4D" modified="2017-10-25" version="1">MAKYLQKDLVVYTGVHNRLKLKDTGDGGRQKMMFLCASSNNDKSITIPLYFWKPDYEPLNNPYVDPTTEDYYVCEKPMFSKDGALMPRQWKPRNVAKGYSYMNNEILLHDFSAAMVTDLLYVTRKPGDESVDGKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMF1</accession>
    <name>A0A232FMF1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000018">
        <property type="protein sequence ID" value="OXU31904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMF1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14955" checksum="BEE85A0665012E9A" modified="2017-10-25" version="1">MSGFYRLHMYEYPRLIISSFYDGRAKNRLERKAARLYRGSYRRVLYFYFCVSLQMDVRAMENFRSFTRSLLPRVANNNESKFSNKNRLNQSLEIDKTNNRIFAASVSETFLLSIITHSAYRPALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNF9</accession>
    <name>A0A232FNF9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pro-resilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000010">
        <property type="protein sequence ID" value="OXU32059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNF9"/>
    <dbReference type="STRING" id="543379.A0A232FNF9"/>
    <dbReference type="OrthoDB" id="6425109at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF98">
        <property type="entry name" value="CUTICULAR PROTEIN 56F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="709"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU32059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="956" mass="89731" checksum="77FF9F8EC0CB798A" modified="2017-10-25" version="1">MEKRKNKLSQPICRQSSVCTARAKSSFATINQHACLQEYTYKRIVPSCEMRQAYLLVEAEEAAAVASAAAYLAQYQVICLIAVLTLCAARPEPPVNSYLPPGQGGGFGGGRPSGASPSDQYGPPDFQGAGGRGGQAAGGNFGGGGNGFGGAPSSSYGPPGFGSNEPNKFGGVGGGGAGRPQDSYGPPAGGNGFGGSAGAGNGGRPGGAAAAGRPSDSYGPPQGGGNAGRPSDSYGPPSAGGGGFGGGSPGGGFGGGNQGAPQSSYGPPASGFGGQGGAGQGRPSDSYGPPGGGSGGRPSQGGNGFGGGNAGRPSESYGPPAAGGGGFGGNAGGNGGGNGFGGGRPSGSPGGFGGQGGGGRPSDSYLPPSGGSEFGGGNGRQPGGFGQQGGNGAGQQNGGGGAGRPSSSYGPPSNGNGGGFGGQTGGRGSPSNGGGFGGAGGSPSSSYGPPAGGSGFGNNGGAGGRPSSSYGPPSSGGNGFGSGGQGSQGGQGGQGGRPSSSYGPPSSGNGGFGGGNGGRPSSNGYPQGQGNGNGGFGGQGASGGRPSSSYGPPGGDSGYPSGGPSGNFGGSNAGGGGGGFGGQVQDSYGPPPSGAVNGNGNGYSSGGPGGNGLDEGNDEPAKYEFSYEVKDDQSGSNFGHTEMRDGDRAQGEFNVLLPDGRKQIVEYEADQDGFKPQIRYEGEANTGAGGAGGYPSGGGGDSGYPSGPSGAGGNAGYPSGGGGGAGGFGGNGGGGNGYPSGGPSGGQGQFGGQQGGNGGYPSGPQGGSGFGGGSQGSGSGGYPSGGPAGNGGNNNFGGGNGGYPSGGPSGGNGFNQGGRNQGGSGGGYPSGSGGDAAANVGIRSEPQGPGYLPPSGGGAPRPNQGHPDEWAGDPVNYEFSYEVQDAQAGLDFGHREMRKDDEATGSYHVLLPDGRTQYVDYVADGGGYRPMIRYEGTASYPAHSPGGSEGYKYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNS7</accession>
    <name>A0A232FNS7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear envelope membrane protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear rim protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nurim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000002">
        <property type="protein sequence ID" value="OXU32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNS7"/>
    <dbReference type="OrthoDB" id="10050858at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033580">
        <property type="entry name" value="Nurim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040">
        <property type="entry name" value="NURIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040:SF1">
        <property type="entry name" value="NURIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="248" mass="29060" checksum="EF89BE89C8475103" modified="2017-10-25" version="1">MISKALRIAVCTTSFLYTFYVLCNFTYFLSKPIEYDSSVLQQEESLVLKTLWILLINASLLSAFILQHSAMASDSVKNFYYKFNIEDIERSVYNASSAAVLHILISEWQPLPWASIWNFSTSENSKLWFLISAFHVIGWCIVYSGCVMMDISELAGIKQVYYKMSGRPRPMAVKSRELQRYFMHMRHPSFTGFLLVLWIYPLMSLDRLLLASLLTMYMIMMWTIDQDDYNYHSIVIARKQRELSNKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FPB2</accession>
    <name>A0A232FPB2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_007064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000002">
        <property type="protein sequence ID" value="OXU32288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FPB2"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16270">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1790:FF:000001">
        <property type="entry name" value="roquin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000047">
        <property type="entry name" value="Roquin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048968">
        <property type="entry name" value="Apc5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041523">
        <property type="entry name" value="ROQ_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048575">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052249">
        <property type="entry name" value="Roquin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139">
        <property type="entry name" value="RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13139:SF54">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21371">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18386">
        <property type="entry name" value="ROQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21206">
        <property type="entry name" value="Roquin_1_2-like_ROQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="722"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU32288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1504" mass="167007" checksum="65B0176176D3AE52" modified="2017-10-25" version="1">MNKEYLSLDGSGKKSQKECLTPYKVAVVICIKIYTGSSIAEKTVIEKRDFCIAALKMIQSPDLDKKGLFSLINSSEFALERLSCQLKIDLDHTCEQGVKELLDLFDNLGNLIKPLIDNPHVALLNKHSVLGLYVRRTIVMFEKLSFYQIVALFEDIKEFNDADLFGPPLPLSSKNQRPFLQSDNNIWGGRQAELLVAQQAHALLTDEHKALPPAELQALVKDLLSSSPYYAEAHYLSYLNCLRVNEYSGALDSLYHCFDRLTPLENRPSADDKLRTFRYAALNLAALHAQFGYKELAQLALKEAIMLAQEAGDNVCLQLAHSWVYYLTNKNKGPLIERSIAKSTTLNMLHTSSLALIASAHNAAMEGKNPQLVFETLTKSDVLNRQGAMIDLMSMIYAERTALWAYYGKTVMSSVCGQLLLLANSGEKKKIMFNGPSTCQAVVTVANILHEMGEFALASVVLSHAKDRFPNQPSSRIWALADQLHEFTRLMRNEKWSAAEGIAVQISSLDPVESKFRQAEALFGRHDYPGALKIAYELEAMEDLTPQQKVRVKLQISEIKCGSVATGTPMSATSSILLLNSALDIATSNHLSYYAALVNMHIVNVQLLLRMPYQAMRNVREPIIQILAHGGLYDQARAHITYAKCLSANAANHTNNEHKRQIMLEAINQLLKAKKILERLEANDRLKSTLYLLSVFYHEIGMSEERNRMPIQAPQWTEFLSCPVCCHDFDVAIRGPISLGCGHTICRTCLANLHRKQCPFDQSAINTEIEKLPVNEALLQLVGNSVPSNNAATTFQALLSPEDFTHYLVAKRCIEELALYLKPCQATPNNATGIGLVSRPMQRKLVTLVGCQLVEPEGRARAIRAARSLGERSVTELILQHQNPQQLSANLWAAVRARGCQFLGPGMQEEVLKLVLLALEDGSALSRKVLVMFVVQRLEPHFPQASKTSIGHVVQLLYRASCFKVSKREGDSSLMQLKEEFRTYEALRREHDAQIVQIATEAGLRIAPDQWSALLYGDTGHKSHMQSIIDKLQTPQSFAQSVQELVIALQRTPDPGQLSSLRPQLELLASIDPSPESEPPSWTECRSALEAIKIVVSALVEFIQQHGNRKSQDGAHNSSQSKYKVSMCRDLALRGSCPRATSCTFAHSDLELDKYRSKNRKLGTRSSMPINGNADVKSEKALIVSTGGGGGGGGTNKGFKQCKDATNNFNKNHDNSHRENFNQINKSNQAQHTSTNNENFIGSLTNYMLPGTQNVSRIIPQKDIQCGHYIVPTGTGSLDYAAANLHLWDPTQIGPGMQTIFPNNNNNNNKKSRTAAKTLAVLLQRRMEIINQLENMVSKQAPSQMKANYYDIQSDSLYPNFSIWTNAPTNQSNPGNINFTNNFICNDSILYDDEFIPFDASSANKYGPISRLSKSILRPTNGVQQNGLYNDGVANSISTLRPVPASSPMASRFYNQPFTAIGTNGGMQQISNSGLNDAYVTLNRNLPETASQMQIPRQDCMSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ECX3</accession>
    <name>A0A232ECX3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01011722">
        <property type="protein sequence ID" value="OXU16220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="201" mass="22770" checksum="038307D25BB5353A" modified="2017-10-25" version="1">MVLDEQISEKHIENQRSXLHEINSWAFSTTQTETLFIQCPKSAHEIIEIRNAGILRLKPGCTAHTNNARLTASREFRMYSSEIAVIRQDLNLTSVISNYAGIHNFSTLIRNVVKSEISQKARNLHGIHIDSLKTDTSNNPTDTARSEPTVRYIARPPQHTITNLTWDDQINPMPRRGTQTARLLDLSAPQEAWLRAIEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDF1</accession>
    <name>A0A232EDF1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cyclosome subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_007343</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006739">
        <property type="protein sequence ID" value="OXU16364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDF1"/>
    <dbReference type="STRING" id="543379.A0A232EDF1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28672:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="16">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU16364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="306" mass="34586" checksum="B7D82939334203C1" modified="2017-10-25" version="1">MDSQVCGDGRLLDLIDEEWRKDKLPIDEILVPISELPDPESDNGDSHMTLKELEQKWNNLALGTLSVQCFIKECNQLDFLPLDCKYCKNIFCKNHFNTASHSCPQLAENVAENTGKANLFHCSQMQCTTKSAVEMTCDTRQSELERWSKPKEEFLETKKIVDTELRNKLKKSKNSALAIKVQLMKLKNKSVGPSIVPVGDRCYFSVHPPINNGSKIFDGSRGAYVSVNWSIGKVIDSISNSLNIPNSNNLANVQKLRMFHYLNGNIVTSQMDIILSELFRIGSLVDGQDIILEYSTNDRVDFSLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDW5</accession>
    <name>A0A232EDW5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005823">
        <property type="protein sequence ID" value="OXU16545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDW5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="400" mass="44390" checksum="1A8F3D6B2752223E" modified="2017-10-25" version="1">MDSQKPVDDGARSVSMPDNRPAMTDTNTQCPATASLLAMTSLKLLSTRECVTYLKDNIVHFVPKDLNLSTSTNKLLTDIEAIYRDDLTKAKADVGDVSNPAVYINEEWNIENASSFVPERKAKSLSPSPSKPADGLPEDLIKTNKNNSVPSSTVRERMLEHAQKYASPIRAKSPLKNTNACSTALHGELTENLSTIEQKDSEEESEEETFVFQNLSEKLIEENERLEQADNMDSQKPVDDGARSVSMPDNRSAITDTNKQCPEVVPLLGIAEHIAAMTSLKLLSTRECVIYLKDNIVHFVPKDLNLSTSTNKLLTDIEAIYRDDLTKAKADVGDVSNPAVYIKKKLRSFRIARTGELTDTLPRRVLVQTFKNSFRNVKIAITFCYGTCKVLAPEYCLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDY7</accession>
    <name>A0A232EDY7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005825">
        <property type="protein sequence ID" value="OXU16538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDY7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="192" mass="20660" checksum="6A5E5DC6E34E5AD4" modified="2017-10-25" version="1">MTSQHIRAGPTCPDQVRKDKSGMPQHTSEYKISQGHSMGYKITLKLNTIELEWLESRSAGPAPTNVGLQALRVQCDIPLNSLGLFQSRRPALPLKSDVTVSSSELSKPSALGVQCDIPLNSLGLFQSRRPALPLKSDVTVSSSELSKPSALGVQCDIPLNSLGLFQSRRPALPLKSDVTVSSSELSKHFALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF40</accession>
    <name>A0A232EF40_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005106">
        <property type="protein sequence ID" value="OXU16986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF40"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="68" mass="7816" checksum="44D1EE22A5E8E7C3" modified="2017-10-25" version="1">MFTHWLLRNSLNISHRYLMAIGLGVVDLMSSFAVDTGYTLCDLQLAQVLISSRHYHTYDCVMHTVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF71</accession>
    <name>A0A232EF71_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005136">
        <property type="protein sequence ID" value="OXU16962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF71"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="20020" checksum="7D4F31B3E3B637E6" modified="2017-10-25" version="1" fragment="single">MEARLVKESDANREKTCPSFIHCMINENFHVVFCIKANVNHTICSVHLDSKVRCINARAVEPPRATARQIYPSKQQKSFDISRHSIKTLVSHSGKSSKEPGHAGRSRSSSQSHRRRAEPVSSVCMRTKRRKLKELRQGRKSSGCFEAEGLSFAGQKQLADLPRLDACYELIKMIAGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG15</accession>
    <name>A0A232EG15_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004890">
        <property type="protein sequence ID" value="OXU17291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG15"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="15330" checksum="24778151E34F5C2D" modified="2017-10-25" version="1">MEDLRSPVHKKQTVRTQETATSNLMVDLQRTQAENPKLFQMLQKSPVHQHPNDITRKNSTPNINKQPNKHQATNSSRHLSRLDENIPQAMSNLMADLQRTQAENPKLFQMLQKSPVHQHPNDITRKNSTPNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGG9</accession>
    <name>A0A232EGG9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004767">
        <property type="protein sequence ID" value="OXU17441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGG9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="132" mass="15378" checksum="D2925ED46D772FDA" modified="2017-10-25" version="1">MTRDVWNEYRIRKQREQINIEQYDLLDYRKCINEASIRVLKETLTTKPDIVDPLFKDERTQRNSTPLILNKPDYESFQLELQILRRAKSNANVDVVTNHSLPNGIPNATKLLSDAHIRTRGTPLSNRPDCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH44</accession>
    <name>A0A232EH44_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_014645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004607">
        <property type="protein sequence ID" value="OXU17665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH44"/>
    <dbReference type="STRING" id="543379.A0A232EH44"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08824">
        <property type="entry name" value="LOTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09972">
        <property type="entry name" value="LOTUS_TDRD_OSKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="5">
        <location>
            <begin position="225"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU17665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="584" mass="67096" checksum="B82D21E27277E934" modified="2017-10-25" version="1">MAPSLATLDGIKSDIRCLLISRNSKNITLEKLNKMYKDVVDEDIPYKDFYFTSLEKFLRSMPDVLSLRLNQANELCAYHIDTEKSQHISSLVAREKPEADSSLRSKFKVYHANPIDPRILSEVLQELKNSPLHEKKKITDVLSAVVKHVGRYAFYTIKDLNSQLNECTHLLTHDDNYIHFKDNTPASNNVISLKNMQTKNAGSKLKDISNQMTKIVDLSSVGNLIKESTKIRLRKLIEKHVEGIWCSELPQIYQREYGISLEYSDLGFNSIVDFASALPDIFQIVKPLNSKRLMLLNSKICKGISENHNASTSTFNKCIEETPYESGIISTPMLDKYYKALIPDDVMAFNDSVDQIRVNELLINPIENSYHVLVSEVHNPSFFWVTLCQNKKKISCLINKLQNFYARENHNYKIPHEILKPGLNVTCIFAEAWHRGIIKKFKSDGLVVVHFYDYGTSSSFDPDQLYFLNKQFSTLPAQAIPCCLNNVKPLGTVMWSKKINKIFTEKVFDKSFSAHIIHTDDKNNSLVVDLVDKNNDINERYMSLWMIANKLAEHGKFICQIKNTSFTHYKECWNQNPNEKLNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH91</accession>
    <name>A0A232EH91_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004574">
        <property type="protein sequence ID" value="OXU17703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH91"/>
    <dbReference type="OrthoDB" id="7700376at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17378" checksum="C4816446038CAC47" modified="2017-10-25" version="1">MKFLNNDKTAITNFIQDQLWHKQISAFDKNGIILPLFGYFDDVELGNSLESHAKNNEVGAVYVTLPSLPPNFTSKLESIVLSDIFYTNDRKQYGSGVIFKRFITELNDLRKNGIELVINEKNESRTVKVYFITTLILGDNLGINSIFGFISSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHZ7</accession>
    <name>A0A232EHZ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004411">
        <property type="protein sequence ID" value="OXU17938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHZ7"/>
    <dbReference type="STRING" id="543379.A0A232EHZ7"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="226" mass="25485" checksum="7C90ACF05B101F76" modified="2017-10-25" version="1">MSRSRYIPRTFRQRAPSEFEWPGVFFANSENQVFHARCQLPGHRDKREYEYITHTRTRLVIFSSYNIRCAELIEFPLLRVSRAMRPLLSSPLPFLSAGESDSPLAFSTARSSRPTYIAVPAISLSLDQQSTGSYLAIMSLDENFNKAAEDVKELASSPADADLLELYALYKQATVGDCNTSRPGMLDFKGKAKWDAWNGKKGMSQEEAKKLYIEKVEALIASIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EII6</accession>
    <name>A0A232EII6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004236">
        <property type="protein sequence ID" value="OXU18163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EII6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="14904" checksum="B92133B688177F88" modified="2017-10-25" version="1" fragment="single">NSKIDVNRRDCNGNTALRIAYWNNNYIKVKTLIDAGAVLYPPLAISIILPLLARETEKGQTVNREDIPILENIYPEYYEDYIEACQEWQRMQQTLQRRYFDCQNNDYYLATKEPIRFIRNSLFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIT9</accession>
    <name>A0A232EIT9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004182">
        <property type="protein sequence ID" value="OXU18228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIT9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127319" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7696" checksum="F66C03EE6836287B" modified="2017-10-25" version="1">MSIWMCVYTVIFLELLTNMHLKENNITYFAPFSPRDRPLCSADKMKKGCRCTSLKSIPINLCQNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIX9</accession>
    <name>A0A232EIX9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase kurz</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004159">
        <property type="protein sequence ID" value="OXU18268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIX9"/>
    <dbReference type="STRING" id="543379.A0A232EIX9"/>
    <dbReference type="OrthoDB" id="10025033at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000046">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000895">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="287"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="582"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU18268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1219" mass="139016" checksum="14336488F11B2684" modified="2017-10-25" version="1">MGRKKGYNHKARSATNIEIDNSTTNKIAIDISHRQDEFDSCNALVLPNEKRKTKNKDKPLTVTRLLSRKKRKQLEKIVEKKKKKKDRAALVEELSKTTIPEDELKQYTSLTSVQTKGLKRHLRETQLEELINKAEISNRDESKETIVNSLKGAKRLRIAILNKAKEQNATNDPNTLGLEESSESEDEDNNEDQEEKNENDIEEEEENEKSVEQEEKHENVIAEDTKTEIPTVSEKTKVSAKVEKSSKLIEKKVYEKKPAVFVTLDRKPEVQEARLKLPILAEEQAVVEAINENPVVIITGETGSGKTTQVPQFLYEAGYTRDKMIGITEPRRVAAISMSKRVAEEMNLTDKEVSYLIRFEGNVNPDTKIKFMTDGVLLKEVQNDFLLTKYSVIILDEAHERSVYTDILVGLLTRIVSLRTKKGDPLKLIIMSATLRVEDFINNPRLFKEKPPVINVESRQFPVTIHFNRRTPEDYVKEAVRKAAKIHTQLPEGGILIFLTGQREVNTVVKQLRKAFPFRQKKWAKESKGKSKKKGSSKDAKENQEQKDDDESDANSEDEFFAKSSKNKRKKMPKPLKLPEVDLDVYSAVPPDDGQDDLIDLENSRLEDENELDEEDEEAIDLSGASNLQPLWVLPLYSLLPSHKQARVFEPPPEGCRLCVVSTNVAETSLTIPNVKYVVDSGKSKIRMYDKVTGVTTFMVTYASKAAANQRAGRAGRMGPGHCYRLYSSAVFNDQFEQFSEPEIRRKPVDDLLLQMKSMNIDKVVNFPFPTPPGEEQLRVAERRLCILGALQQPNIMDKKNLYSSKITDLGRSIAAFPVLPRYGKMLALSQQHDLIQYTVCMVAALSVQELLVENLGMEENVKNKWTQTRRFWAGHGNSFLLGDPMVLIRAVGAAEYASTKGKLTKFCEEHGLREKAMVEIRKLRHQLTNEILLGVPNLDLVINPEMPPPTDVQAKLLRQIVLAGMVDQIAHKLSSEEIKEYSSKEEGSNIKWKYAYKTLEMEDPVFMHSMCVLRKSAPEWVVYQEVYETNKTYMRGITVIEPEWLPKFAPSLCSLSEPLLEPPPRYDKETGKVLCHRTGTFGPAAWELPMVEVEFPNNLEGIKWFARFLLEGEIFPKLKKFTPSLLTSPSSLNKTWAKLLPRVELITKLLLSKGIMTKDKLIEIWEDDSKFLLSAYQKWLPESAHAEAMLMWPPFFIKKLKQTCIITGYLIIDYFELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ90</accession>
    <name>A0A232EJ90_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_006328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004060">
        <property type="protein sequence ID" value="OXU18423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ90"/>
    <dbReference type="STRING" id="543379.A0A232EJ90"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU18423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="88886" checksum="04C480767A01EB78" modified="2017-10-25" version="1">MNIKEVLLHFRILVQSLIYHNSLPPQHIIRAPYRHITHGIPLSGYEIQSPFIPISSIQKTQQPHTTKLLNRLTTIYESAPSIDDNDRIYRNRTANSEALQHFTFGLRSPLDHQVRSDHPKSLGEAIRLAIEYECKQSARINKYQNTNNQNAPHAQLNFTTAKQAQSKNEPTNGNKNSNTNVKEKEALSFTCNYCGSKGHLQPACEKRKKEKGFGNNCGSIGHTIEICRTKEYELNNGRNNNNPNTNNGRRNDNDNQNNYNNYGNQDNGDTCSIQSSSVEQTGCMVLNNKKLSHEPEFPQRHHAAGNLKPCREPTDTVSRSGLSDKKSSCHSYKLPPSTAQNNSTWVQRVAENKSENTATNSCKQPNTAVIRWARAGRSPPLISLQSEYIIRNKADIYIDTGAEISVVKRKYVNENISQIRKNTILAIRSVVSGKCTTLGTLNMDIGHGITCNLHIVPDSFPIDVAGLIGCDIIREYNREETFTIPARSRQIIFAKATNPEVKLGYVPIQNVGPNILFGNFLATNKNNMLYAYCYNTGHCPVKIPVPHVELIECLTPRHPSGHVIYEDHIDAYNYVSIRKLFFNTKEPIDVAVKNRILAENPDLGEERIDKIMFIIDTEGCTEEEIKHVRDLIKDFSGVFGLDGEPLPATNVLQHVIKLQTGKVVDAKRFRLPVEELRNNQIVEPLYSDFCSNLWIFSKKPDANGNQRWRLVVDFTQLNDDTEGTTWILPFTSDILELLASANVITVVDFKQGFHQIPIYPDSAPYTAFSTPVGTNGFQHLQLKECLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJB2</accession>
    <name>A0A232EJB2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004082">
        <property type="protein sequence ID" value="OXU18398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJB2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="11915" checksum="86A5334DAED91F98" modified="2017-10-25" version="1">MIIGSKTGQLTNLTWNKHECGCGVVRKSMCAMRHVMESKQPRFGATTAKHEVSSRNDHVGHSRTPAHYLAHSYGLENKQTSILELEHCRSTKCDIDSCSYQNPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJT3</accession>
    <name>A0A232EJT3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003948">
        <property type="protein sequence ID" value="OXU18605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJT3"/>
    <dbReference type="STRING" id="543379.A0A232EJT3"/>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263205" description="Peptidase M12B domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="91"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU18605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="386" mass="42021" checksum="4EC0CADB948C16BE" modified="2017-10-25" version="1">MNKHSLLIVSVLGLAVSVLSSNEFFIGSNTPVWFLESNSADSESPRLSIIPNALEEAGLSENNATLHFLDNRNDEDSHKLLKKQTKGLDELFLEILVVVDHGLYRKLAENIADALNYVVSFWNGVNLRYELITSPTVYVNIAGIILSKDPNALYYVQQSKNSRGYVNANKVLFEGGKYFLYEKRLKNYDIAVTMTTEDICSVGAADICYSNIVGLSLLGKTCHSHLNTAIIEDNGGFGGIIVATHEIAHLLGVPHDGTGEAIRCLIRDGYIMTPSASVGENNFKWSTCSQKILHKFSLSSGASCLKNAPNVGSTIIPGLSGKLMSASQQCARARYSTPCFNGKRICNALSCFRTDYKYCDADGPAAEGTTCGENLYCRGGKCVPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJV8</accession>
    <name>A0A232EJV8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003918">
        <property type="protein sequence ID" value="OXU18654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJV8"/>
    <dbReference type="STRING" id="543379.A0A232EJV8"/>
    <dbReference type="OrthoDB" id="6622877at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033545">
        <property type="entry name" value="CEP89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36170">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 89 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36170:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 89 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="405"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="573" mass="67536" checksum="3D8C3259784D3243" modified="2017-10-25" version="1">MSYFFGNAGTSGLIKTRRKKHVRHRSLSNDRGLEPVHGITHRRRHSSDKKCISKAKSVLKESQSHNYDGDNASIKNKNKRCLHKEIVRLVEENRLLTAKLEGTKVDLGNLSIVKERDELLATLEKKYHKLQQNYYELQTSRDKVNALLAQRENEFRQLHMHNEESALIIRNNEQQRNTFIATIQRIKNENVQMHEDVNLLKNLVYRLNLEIEKYQDKLRTIGQTADNQAVVNIIDEVRTNFNNKNVLKAWGKVNFHALGPLLDAYQENVNEKDELIQKYKKEIDEFSGKLKDIISENENLHIEVENMRAKYDRYVEEAKVLEKDAAIVKEQNELLIKQSAMQKQKIQEIHSIYEHKVESMSQDNNKLYKEYLTCKTELSTLKGKYEILNEGYEKLKNISEKTMPISVHNAAIDECKRLFEELKQQYESEKKKSSTCMKQLEEILRENEKQLITITAERDQLRIQARNLEKNLKRTHNKLEHLQSTVQSIQVSRDSFKRQLNKTTLYCEELVKEQEKLAIEKNKLSRLLEEKEKENENIQYLGNNITHRMGTLKNQLKARPNFYLILSSKKQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKB9</accession>
    <name>A0A232EKB9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003849">
        <property type="protein sequence ID" value="OXU18768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKB9"/>
    <dbReference type="OrthoDB" id="6287170at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39075">
        <property type="entry name" value="FI19908P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39075:SF1">
        <property type="entry name" value="FI19908P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="442" mass="48961" checksum="2A7BF137CF1E4763" modified="2017-10-25" version="1">MISEERRVESRPAKEVAKPLERNAGGSSDPTTSSTARTGNKGRKSRRRRTRNSTADSKRKSMASLVDYRKEAQKNTSQTSCSSAPLPSTSLSAVQCLNPAPIRPRSLYTTHTYHAQPEESNFQRYNEFVKYLEAPPSEQWGGMVGNGYANSATTLWRQSRNQKPMGAPPFYPTEDACIYTENVNWREHDAETGIGIGGAIATPHGTISLRLHNKIRVDMTIDRAVRVLNFKNNIVLSLSGSGSASALLHPNGRIYQYGSRVEILAHDVHGNNKYAKMWHKGVSFTSEQCALVYLVDTAGTRTTTDSFSDMSQDFSVNVFYAESRHGPACIQEAAAALAAAQYWITDEGVENWIINNVRISQTPDGLVRIARNSNKYQLRTSPSNGTASITTPFLHCTASLGQTSHLFVRRGERRMHYDGTSFIVRNAGHSAGFDDDNQLKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKC7</accession>
    <name>A0A232EKC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003812">
        <property type="protein sequence ID" value="OXU18816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKC7"/>
    <dbReference type="STRING" id="543379.A0A232EKC7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="507" mass="55268" checksum="A7733306E2B029B7" modified="2017-10-25" version="1">MFSRLCTIQGTITKSSKLLNQSMSTNKNLAYVDGKWVGATSGKTFPVMNPADCSTIDCVPDMNVTDTRLAIDAAAKSFETFQKTLAKERSEMLRAWYNLLVKHSEELAEIMTKENGKSLEESRAEVRYGNSFVEWFSEEARRINGEVLQSPFKNREMFLIKRPVGVAAFITPWNFPHAMITRKAGAAIAAGCTCVIKPSEDTPLTALALAHLAEEAGFPAGVMNILTTSLENSVAVGQELCHNPKVRALSFTGSTAVGKILYQQCASTMKRLSLELGGNAPYIVFDTADVNLAVTGAMASKFRNSGQTCISANRFFIHSKVYDEFVCKFLTRIESEIKMGDGSKKGNTHGPLIKESQLKIVSNLVNDAKTKGATIHCGGKPLPDVGSLFYAPTVITDVTRDMEIYGKEIFGPVAVIHKFDDEEEVLQRANETPVGLAGYFYSGDISQIFRVARNLQVGMIGVNEGLISCTEAAFGGIKESGIGREGSSHGIDEYVDIKYVCIGNVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKD3</accession>
    <name>A0A232EKD3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003810">
        <property type="protein sequence ID" value="OXU18824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKD3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="157" mass="17173" checksum="D85F18E639F55DB0" modified="2017-10-25" version="1">MEKQVSVSKSLTTVKIILHIFYLLSRFPHFILNTSNISTRVTSYDCFEGYEFKARSSANNNSPLATSNSTDVESSCDVDIVASALVEKYPRWWLAVEVGQYKCRGLYDTGASSSVLGPTRISLAASLNRRIRPHVGPGGATAIDGPYVPIIGSVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKD9</accession>
    <name>A0A232EKD9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003809">
        <property type="protein sequence ID" value="OXU18827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKD9"/>
    <dbReference type="STRING" id="543379.A0A232EKD9"/>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF52">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="227"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU18827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46551" checksum="4847EB66D1D6521F" modified="2017-10-25" version="1">MKLTCNVEVYNRLANLAPNIARRKPQRSCLAIGRQSVKNQEIHLLLQTSTNKNGTKYKVDNNIEKVFTRCINEGKATIRLKEPPHDINISCDPIQLKSFLHVLKLGLSKKLDPAVLTLSNLNAKPIKAPPKTKIVIKQTSEYPVLQGFPRTTEELCLAGLQRKSFDRQILKLQSLRILNLSDNNITSLPQELGTLAKLQELNVSGNQLGKAPISKWSWLSCSNIAKNLRLLNLSNNQMSQVPEQINKLGGLVTLYLDNNLISYLPPGIGSLNRLKFLYLSKNNLSHLPGSMRNLRLSELDVCDNKFDNNDNKTLSVCNIKVPSLVDWAARIVLQSRTFYDASIIPYTLIQYLDKAKYCMCGAPCFDCFIRRFMSMNLSLIAQSFKFSGTAGNDILFDCYFCSIRCVRKFKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL60</accession>
    <name>A0A232EL60_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003623">
        <property type="protein sequence ID" value="OXU19090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL60"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="10957" checksum="E7584DC2BC9FD21E" modified="2017-10-25" version="1">MVGVIARTTYPTQRPSPIRARMNALCRYTAVSLIFGPPAPPIRYGGDYSAGVSEIEEPPTRDVDFRVAAVQRDMINAQKNRFINSQNYLEILKTAIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELA7</accession>
    <name>A0A232ELA7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="15">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_013587</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01003584">
        <property type="protein sequence ID" value="OXU19149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELA7"/>
    <dbReference type="STRING" id="543379.A0A232ELA7"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="16">
        <location>
            <begin position="15"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="17">
        <location>
            <begin position="361"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="304"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU19149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="512" mass="56682" checksum="C61040F712C17610" modified="2017-10-25" version="1">MLTRLLSIDSFVFRKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGQSLSFDCNYFIEYFALDLLMEDGECRGVIALCLEDGTLHRFHAKNTVLATGGYGRAYFSCTSAHTCTGDGTAMVSRANLPNQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLVNSEGERFMERYAPVAKDLASRDVVSRSMTIEIREGRGVGPEKDHIYLQLHHLPPEQLAARLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGIPTNYRGQVLTSKNNQDSVVPGLYACGESACASVHGANRLGANSLLDLVVFGRACAKTISEENKPGEKIGSLRTNAGEESVANLDKIRNAKGNISTAELRLTMQKTMQTHAAVFRQADTLQEGCKKMSALYKKLDDLKITDKSLIWNSDLIETLELQNLMVNAMQTINAAENRKESRGAHAREDFKDRIDEYDYSKPLEGQQPKPLDQHWRKHTLTHVDINTGDVKIDYRPVIDHTLDDKECKTVPPAIRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELX8</accession>
    <name>A0A232ELX8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cyclin-dependent kinase 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cell division protein kinase 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_003270</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003487">
        <property type="protein sequence ID" value="OXU19341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELX8"/>
    <dbReference type="SMR" id="A0A232ELX8"/>
    <dbReference type="STRING" id="543379.A0A232ELX8"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07845">
        <property type="entry name" value="STKc_CDK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000289">
        <property type="entry name" value="cyclin-dependent kinase 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000256">
        <property type="entry name" value="cyclin-dependent kinase 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044093">
        <property type="entry name" value="STKc_CDK10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="65"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU19341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="408" mass="46109" checksum="78849C7FE9ACE44A" modified="2017-10-25" version="1">MTKVLLDDKKGNDANDTEKKSSLDAGPDPTAPITRKGVLTSFLTGKPMDIPEQDILGKCRFVSEFEKLNRIGEGTYGIVYRARDTKSDKVVALKKVRMEHEKDGLPVSGLREISVLLSCRHENIVHLKEVVVGRSLESIFLAMEYCEQDLASLLDNMQAPFSESQVKCIMLQVLKGLRYLHHNFVVHRDLKVSNLLMTDKGCVKIADFGLARWFGLPLKPMTPRVVTLWYRAPELLLQAKTQTTSVDMWAAGCILGELLGHRPLLPGRSEIQQLELIVDLLGTPSEAIWPEFNALPALQNFTLKQQPYNNLKQRFPWLSAAGLRLLNFLFMYDPKKRATAEECLQSSYFKEAPLPCDPKLMPTFPQHRNMKKSAKEVREQEPVVSDQTNNLPAISDLLGSLVKKRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN03</accession>
    <name>A0A232EN03_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003262">
        <property type="protein sequence ID" value="OXU19716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EN03"/>
    <dbReference type="OrthoDB" id="7741006at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759817" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="952"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="960"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1388" mass="157427" checksum="488ADC07855AF258" modified="2017-10-25" version="1">MTGNARFLRCLILLLIAFRSSDAGESTTLSTASTIGGIATKIVNIINHATDGVRYLNRKLSDPAYKGDNTKRLIDQVGSNVLDELRYLSQRRDQFRVDVENFKNNVISKIDKVVPALVELNRRFSVVFVDSMNVDKAYDTFYEYLKNPGKYKSDVLVKFALDSVAEDNCGLLHLLTEIDSLLTLEETSTPSTIKLLNQHIQLFLRLTNVAQSPQQFLYNFLVSVLYTQMKAYITMKYSFEVLESHETVAVTTTIISGLITAGVFVAKQVRNNERRLSDPAHRGENVRRLFDRLENNVLDQLQYLSKRRDQFKIDVEHYKNEEIEKITENIPPIVELLRRLSVVFVDSITIDKSYDSFLEYLTKPEKYNRDMILKFAMDSLSENNCGLKHLITEIRTLLLESAVSSPSALTLFVRNSELFFQQFEFSQSPQQFLHNLLISLLLTETKAYLTMRFSYDVLELYSKKVSKKRTCLSLNHVGQYSGHIKRLEQDVAIRINKTISTFKLAMANVPREIWENNPPQHEEDVTFTELKNVFQSYVINEADFKNDGSCGNTCKDFKLALAAVDCYYDKEFCNKHQRCSGILHDCVHQFDEEMFVCLEEKNSTRRYQYIDVGYQRYGLEDQKCSSKAIELDRHYSSHNMAYCDPCMCLCDDDAHPKTERYFSLIPSIAAVKENYVLTGARLVKLKRTIHIQIQQGKLLPYGHVNESTVEWVPIKVDVLAKDEIYKIKWLGSRTVFLDDIEVPRNNVVVGLGFKALQQNNIKVLRLVAYSAPMNYSAGVLTDDTYERHSSEESSDEVDLKDLDIPTRRSSRIVQKSTNHQYVKFRTTSLLSDVGQSTIPFLDTQSVTTNPASPMSGAGIYHRRSPGDGGFLALKLFTFNVEPELRADIVDTQLELNGLWGNRWFVQSDVARMADYRASGFAGEMFSLRDASSSSGNDEDSFGWWIGVESRPSKSESELQPSSDCPSSATASTDDSALRARDLSQTETTVSADEEQIELRSLDGAEAALDSGFGSSNSEARIAVCYTPERLVKSEDFRIVTPSPTFYPTLADLVSSRLASSKAFRSLPADSWLSDGKIECAKPTGVEHLAALLRSPYYESSSSSRSSCGRCCCIRYGGGEVLLHTERCPRNDEERVDPEQEREPVPLFSSTPVTENKDQQLADDTSGVSSVSCSATEEDDEDRLPRRLSDELAYVSFEYALAARESQGDKTSDINEVVSILAGLDSDPRRVEELLLDEDRFREATQSGHDSLTRLALAIEPDVLPIIPIIKVNSSDDRGGGVRSRHRYMPCHAETELEQLRERIERLQGSSKDLHQDISSLRRDFTIDEWKVNHLSEDINKLRTEVYELRYLDDLLKLLKGELERIANRNWPFTVGRTKHGTEEINLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN38</accession>
    <name>A0A232EN38_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01003241">
        <property type="protein sequence ID" value="OXU19746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN38"/>
    <dbReference type="STRING" id="543379.A0A232EN38"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011831308" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU19746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="421" mass="47915" checksum="77181BAD3F82DB93" modified="2017-10-25" version="1">MIFCTVRYIFVFSFFIASTFAKQGFGPGQQEWGYVEVRPKAHMFWWLYYTTANVSSKYETRPLVIWLQGGPGGSSTGIGNFREIGPLDANLNPRNHTWTKDYNVLFIDNPVGTGFSYVESLDLLVTTNAQIASDLVQCIKGFFDNVTIFSKTPTYILAESYGGKMGVEFANLWYKEQLNGGIKSNLKGVGLIDSSISAIDNYSFFASYLLHMRLFEQGFVDNNGYRIVDEIAKKLEAAGEAGDWNEVIHFTQKIENLIVNITNNMDWYNILKKVETASVNSTDELVGLMNDKVKKALSLENRWGVQSLYVFLSLLEDNMKPVIHQVENLLNESSLKVYVLTGQLDFIINTPGTLQWIDKMRWRHAVEWSKAPMVPLVINNVIEGYSKSYDRFKLFWVNRSGHMIPVDNPIAMKSILQDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPH9</accession>
    <name>A0A232EPH9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002922">
        <property type="protein sequence ID" value="OXU20289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPH9"/>
    <dbReference type="STRING" id="543379.A0A232EPH9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="266" mass="31230" checksum="890AC902F539108A" modified="2017-10-25" version="1">MQTLNVARFMYTKSNLLYGFPLTPVNPKGYLEVYKNRFQLVIIRVDQVLQGHGTTNTGNLARRCFNDPSKFSQALEIDFVLVNNIALILQLLRSKQEINIEKFVTLCAETYNRNYTVYPWSRMCPLVHKLLKHSSDIIQNFPLPIPFYSEDANPLIPIMYINNRLKGQLKNQTLPEMSKYFKESEQMEYEEPSNELRHGCFRDNLHRFKVEDNPNCPVYLETSKDAEHVFCNCLRYKMERKELERYLQTRVTSESMMTAMPSSKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPI0</accession>
    <name>A0A232EPI0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002935">
        <property type="protein sequence ID" value="OXU20270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPI0"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF39">
        <property type="entry name" value="IONOTROPIC RECEPTOR 56A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU20270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="87617" checksum="694040EFB4F5A28D" modified="2017-10-25" version="1">MEFIDLKTVLRLSYTLITFLVIPAVSLDGLNWIDHVVDSMVNDMNVQHTTIITPSPNEISPVSSSFNSHILDLMKHVKLVSALKIRAGSKPNILIFFINGNYKFDVQRFFKEMWSTVYYLYITIIEVMDQARSSKQLSTSRCKTQMNISVHQHNPFNDSYEVAPWSENSKLYNEKLRNLHGYVLRAVQRDRHFAVIPFKYYTKNVKRDSFSQAVSNTEYTVMKTIAETLNFTMNTTIISEEPNVIAQFDNILRANFDLYVNSIQSGVLDGVPGVPYLHETTHMLIKQYGYYDIRVPWNLILATSALLVIIILTKYSLHLFRSNSEFASAYNIAMIVFGLSTPVEPQKLKEKIIYASLLIISAVFSAELLEYIINVSISRKQYYVFNTLQDVIDSGIHITMERRTHIGILESINITVIPNEHQECINLMTENDTVNACMSDIIVIDDMIEKYSKPQDGWIISKVRENLQANNVIRFMLARHSPYANDFSKMIQRLVESGIPIYWLKSAVRMLALKNNDTIDSRSSFADINIDENQINDYFNDERPLAVRLIYVLVVGHVLSTLIFMIETVTQKLRNQKHKKLCSRALEKKEKLEFTEQEKERAKTLLRVDGEPSPTYTKRKISSDTLDGRRCHFADIDIIPDALHTNAAQPNGNVDVREGKKRLCWNYRVMEMPVGSIIDVTRNFRNYHQAGDTLAKFDDDLWEIKAKKPDPIQERNIKKVSRNLREVAADAMMTFLPTPRPLIRIAWGCIEYLVTGADENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPJ3</accession>
    <name>A0A232EPJ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002931">
        <property type="protein sequence ID" value="OXU20274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPJ3"/>
    <dbReference type="STRING" id="543379.A0A232EPJ3"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="151" mass="16954" checksum="CFF7746D6EDE411F" modified="2017-10-25" version="1">MKHMPVEYCGYTAMDRRCAAPMIPWIISEIRKKNVPQKVNLLVASGFVSAYVTNKEQPLFKHPLRGTLKPQVAPPSCQDPKAGTFLYMIKGDEGLYYYHLFRAKDADAIILSCYARKKIYSTQKENTCIKVHHATRDISGAGELDTLAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPQ8</accession>
    <name>A0A232EPQ8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002916">
        <property type="protein sequence ID" value="OXU20318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPQ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="212" mass="23850" checksum="886776CDE30C6375" modified="2017-10-25" version="1">MHIKLVVLTTTGCTHASGRLGFLAVKLIVLDTIRCNRTIALVILVARVSCVSVSLLDFEYLIINSRNNSFQREEREPVQHDTDEEDEEYYFSTTDECDESESSDNNLSDTDADDDDDEYEDDDLCIKNARKPLYPGATINVAEHVLSVLSLMLRLKMTGVLIAQIFSLIRLHCIQPNYCIKSIPLCDDISIAKSAIQNEKMAKKLNAMSVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQN0</accession>
    <name>A0A232EQN0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear receptor coactivator 6 TRADD-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002737">
        <property type="protein sequence ID" value="OXU20663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EQN0"/>
    <dbReference type="OrthoDB" id="5967287at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026638">
        <property type="entry name" value="NCOA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032715">
        <property type="entry name" value="NCOA6_TRADD-N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15690">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15690:SF0">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13820">
        <property type="entry name" value="NCOA6_TRADD-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear receptor coactivator 6 TRADD-N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1414"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1714"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1950"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2003"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2087"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2302"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2340"/>
            <end position="2386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2415"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2549"/>
            <end position="2706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="833"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1491"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1771"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1806"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2020"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2033"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2092"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2116"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2135"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2163"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2191"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2304"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2563"/>
            <end position="2575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2576"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2598"/>
            <end position="2623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2697"/>
            <end position="2706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2706" mass="287758" checksum="40923F3DE25C233D" modified="2017-10-25" version="1">MAADSDGDLIETVITCEGDIGDPEFPEKFQVIVDQLKSLVCKDKEQDLRVDKVEPWNSVRVTFSIPKEAALRLRELAAQGSASLKQLGILSVQVEGDQVISLRIAGRYGGEAQEIVLQSGPSTESGSKTQSDTTNSAASIDNNATPVPGPSNASSIAATLCNVAQMIAAGPSTEKQPQFRSPNVVAPTDCEPIPPFLTKSVQPSVAGGSGVVGGIASNQQQVANASGSSPRTSYNGPFPFASMTHAAQAIHSREASQAQGQTAAGIKSTVQFKHHNQPPPPYPAQDGMATVTSPQAIHMTPQTVSAVGPSNQYKSPNVMASSPSPNGNIAISANPVIGGATTSGGNQVVLSSPLLVNLLQNDGSTSSSATSSAVHVNAQQQQQQKMLPPAVVDGANSMTNRMRPQKKPTVRRKDLVVSPSVSPPSLDSLRTEDLIVSSGVVADLGHGPSAFATVNAGQTSTVPQQQQLMQAPQQQQLLVQQQPQQMQQQQTLVPAAVHTQVQIQQKFPVRQELAYRPAIAAGVSQQQIQMQNQLTARFPVNGQQVRTPLQQRQQLLLQQQQQQQQQQQQQQQQLSQQVLPVQTQLMPQQQIVTSQSMQASAGAGQLLQQQQQQQQHQQQQQQVLQNASVGVNVNQQRLAYMGPQQARPMQAAANLVGQQTPPPYPRISQQQPQLQQQQQPQAQHLGSQQQQLPQPQLNQGMNVQQQLHHNQLQKMNVNTGATNDFRYGQSQNILSRNYQGQSATVTASSIGGESNGTTEAATPAWGTQNIPISQGAQVNTAQRVPVASGSVVSSAASVATTASTSQATPGACTVQSSSSMPLSHVANHITTTATTASLAPTSTTTTLAKPSETSSGEATKTTTTEEAPIEPEFTSSGKPRQYLINPLTGLLEPMPSDTSDSEPESALETQDDFFSFPSPFNDRSNSIFSDDDADSNFSRRNDTTTNTDQSDSENTAKSTASESSLKHNRLKPNRDSNSPMPTEKIKLRLKLEKSEPVTPAYKVDVSFVNTPPVRKADKSTSKSAFSTSSNLPNVSVPSTGNTGTPLVPTTSTTPTTAIATGGSSPGVGGTGSTSAEEPRVPPLHISLRGRNASVVQIGKKEKKLLKESTSTAELDSASVKRRGKLKKIKDGTDGNKLLQKKSLNTIIGTSSASKLPLSNSTMVNSANALVKMNNTVQTTLVTKTNALKQESSSSTSSSGSSGNASPMEVEPRLQQSSTTTVSTATIATTTTTTSATKQQPQQQPQQPASKVGGASDVDDLPLNSRIPSPIKHKSSVLNQQATQNAQQQATGESDVPNHTSEHKIGGGKTKRRDSKKKAEPSEGMHREQNLLTGGRLVDNQAKWRKLGYKGGEAVAVSTGQTVKKTIAVMGATTGAPTTTPTSGNDLNVVKRVGELRRTSDGDIVSGRVAGEKASAAALNTRQPEPNGVRKDLVSHQEKRRRLSLLDEKDLHTIESQSVETMQLMSQKSMSDKVSQQKATLTTVQSTGAKINSNSPFENENSNSSNSPVPPKITSLAPQPVISTSLDSKITTSTTTTPMLAEMPSLPSKTTVTQSLISTTITTTTTAAVKTTLVSKQLKTEVVDVSKSQNVIAQTQKLKNHSLIATKNDINRLASAALQMKKLAQNHHVLGKQTNIVPNVIETVQRVSLLKTNPAIEKISEQMISKQEPTSNIVQQLVTGKPILPIGDINVTEAKVKQKLLESESSSNPAALTNIVEQNPNNNVVVGGTGNGGNSSNTGGEDSGIESMDALSEKSPNQGESPLHRPAASQESVTTTSSVNKSSSSLQQQSQPQQRTEVQASAPQQQTTNKNNVPSSTVSNSSNDMCSNLRSAESKDSYENYLDNESEKTVSVAPSTTELTIVTTTVTTATTTTIAPIPVEAVVTEEKPEKVQEKPNNPLVTAAPTTISALVKVKDDDQSKCAKDSKDSVSSVSPKLTAPVVAEKVKVKCEVETEPESSNPHKCDPSSSSVGVSSEIAIEAPASTMKTTTTKDVKVENAGAEVAVEDKKPAVTTSADTLTRLADEEPARNPREQSNNNNSVNNNNNSNNNGVPVIQNHVATNVVKIEKSECNVDKAEVSGSSTATLMTATSPKLELKSSLEPKVEVKEEEPKIDDTRQQQQQQQQQQQQQPPQQPKVENKEVKKEVKKEEPSKSELVTVDQSQKSNVQSQQHSSESSVNPSKVADDSAKKVTASEGTSSSTSASTNTTSTSTTSSSCDLNVQSPLAGDDPQPIRITPPLYTYSNPVVLQRDDTPSPAPQTPTEAEPAEAVVAAAAAAAEHLKRKRRRKQELEGRQDVICLEENDEGTTNAAQFNSVEEYGTGKQLRGPAKSLLEQLLIEIPNDSGTNSEKRSLRTRSQKSSTALNSPDVVKTKCSPHERRSISPYAKAKLQPAAAAGATTKLSPVTAANVSVATGVTATKTTGKRKRQESESSVASNNEEQHQLTQPRPGKRKCSENAAGLIKACMGVDESAGGPVKRQLATGKDETSKKGFNILSKSKKGVYLDESEMKSCKEDSLIGVRAQGPMLVDIESSDEEHSIEISGKVKIRASDELCTGSPKPKDQKSSGGAASGGHLHSNAVTYNSGNGRTQRESRMLTNKQLQQQQQQQQHSQQQQQSQSQQQQQQSGGGAATAGGPTIVKERLRGSSVSSNESVGLGEMTTRRSVRQSTASPLAAPACNTRGASRSMEDVNRRKTRSGAADKDAEEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQZ7</accession>
    <name>A0A232EQZ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PRANC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002717">
        <property type="protein sequence ID" value="OXU20706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQZ7"/>
    <dbReference type="STRING" id="543379.A0A232EQZ7"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58706" checksum="8BC3A149275C92AD" modified="2017-10-25" version="1">MEEDQEPERRRMDPRAIPLLFSLKGVNINQKTDDGETMLHVAVRMRDKEVAFVLLEAGASVNIKDAEGNTPLSSAIEIESSDMVDLLLKYNPDFDIDIVRDKFYTSLMGSSSDDEKIVRSMIKHGFTVKETDNFSTTLLWAVVLLGLEDFAISIINYKTNFIESIKVWYRSFLLMTQPFTEKQTEILGIITKIIEHFLPGQKVDMLGNHNQLLFKILLSQCDIELINVCVMSLGGSFNDNEESDIVAITKDVLLNCYDGDNPILDKYGRTGLHYAAKVGNVGVIQALLDMHLDVNVTDEDGKTPLNYIHDRISEYSKSDNSNEVINNEKHFDLEFNCDFTLLDLKIGAVLLIKHVSKLITSNSYITLKNLKTVKSLLTMMTKDTEMAPYYLSICSFIEQCEDEINLMKNQKLVELTYFDFLKKNYNQIALYTRRKEVIEAFQSDNKFLKDLEIYGPMLERRFQVSNIRRGLIENVESIVFDILKWRQLSLVVVREILSNLNNEELTFIVLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER59</accession>
    <name>A0A232ER59_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002653">
        <property type="protein sequence ID" value="OXU20859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER59"/>
    <dbReference type="STRING" id="543379.A0A232ER59"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012918009" description="Carboxylesterase type B domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="23"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="572"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125308" checksum="B98C41957E6CA1EC" modified="2017-10-25" version="1">MLWTSLVVLLASVILVNCKDDYPKVKTTLGAIRGYYKKSENGKLYEAYEGIPYAYPPIGKLRFRPPKKIPAWTGELQATKVSDACLQYMHIPAVENERVEGSEDCLYLNIYAPLRKADTSPLPVILWIHGGCFQFGSGNIYGSRYLADKDVIFVNINYRLGSLGFLSTEDEVVPGNMGLKDQSMALRWVYDNIEYFGGDPKKITLTGLSAGGASVHYHYLSPLSAGLFQNGISFSGTALLCWAQTENAREKAKKLGALLGCPTDNTKDMIQCLRYRPARTVVQATSQFMPWLYNPYTPFGPVVEKSGKDYFINKPPVELIASGNVQDVPWITGVVSEEGLYPVAEFITNKKHLKDLDDNWDLVAKYLLDYNYTLPKDKHAEVAEKIKKHYFGSKPIDRLNTRPLTLMVGDRLFSVDAEKAARMQAKINKSPVWFYYYSHRAADSLSDAMSGTKENFGVSHGDDALMVIESPYTNPTKTQEDRALQRDLLNFWVSVATKGKPELGTEWTEVNPTKKELNYLHISGPGKYAMETNDNLGEKNLWNSIDFNENKPASLFLVVTAFCLAVRSDDDAPRVKTLLGSIKGYHKISEHGRLYEAYEGVPYALPPIGKLRFKAPQPMKAWEGELQATKQAHACLQYNHKSGWLKDVELVEGAEDCLYLNIYVPDREGDTSLLPVFFWIHGGAFTHGTANGFGAKYLVDKDFIVVAINYRLGPLGFLSTEDDVVPGNMGLKDQSMALRWVHDNIEHFGGDPKRISLAGISAGGASVHYHYFSPLSAGLFQNGISFSGTALNCWTQTENSREKAKRLGALMGCPTENTKEMVDCLRHRPARPIVQAVQEFMPWLYNPYTPFGPVVEKVGNKPFIDRPPVEILASGDVADVPWITSITSEEGLYPVAEFAANEPLLKELDENWESLAPHLLDFNYTIPLKERAEVALKIRRHYMGNNPINRQNVRPITKMVGDRLFVVDAEKAARMQAKANKSPVWFYYYSYKAAGGSLADALSGTKENFGVSHTDDIYLLFENLFFDPTTTESDRSMQSYMLNMCSAFIEKTKEVFPKEWKKVDPSEKDFQYLHISGPDKYKMDSHDNLGDKQFWRTINFEENVLESSGSAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERS7</accession>
    <name>A0A232ERS7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002555">
        <property type="protein sequence ID" value="OXU21059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERS7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU21059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="11653" checksum="69F00FE8738FAE15" modified="2017-10-25" version="1">MDEESLLTAKIATARVYIERSNQRIKTFKILGSILPSTLMPLIEDIFIVICGTVNMSAPIALISAVFPTIGHFISNKATGFLFFMSTSSASVILLVSLETIGSCLPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERT6</accession>
    <name>A0A232ERT6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002550">
        <property type="protein sequence ID" value="OXU21074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERT6"/>
    <dbReference type="STRING" id="543379.A0A232ERT6"/>
    <dbReference type="OrthoDB" id="10045204at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="337" mass="39063" checksum="7E484DADC65D4DEC" modified="2017-10-25" version="1" fragment="single">YHDLVMALENEISSSDTLERSNVTSLQSDDRSTKIQKSPELNSHNTNLNPQQSCFCQQHTLGKVKLIPCPVLNSNFEPTRQCLCQQFQLGAYYPPNQNVDGNERKEKRRFNLKWPRQSYVNKKDKSYEAKFKNRPYFRNDKPFACYDVLEGMPRKKTSQFKYVIGSSAKHKLNPYNDVDSDQPEKIEIYYFDHGNSGYYHTTDLPPILKTEKFAEETSSKITRFWAEIFGYVHIIFSVITALVLQFLRCILFSLIRPLTVGVIQLVADYFIKPLLSITFNGLIQPFLILFYNVATSLRDCCEPLATALGYYMRELAMLFRSCRLIEINHGHRGNANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESF3</accession>
    <name>A0A232ESF3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002428">
        <property type="protein sequence ID" value="OXU21288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESF3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="180" mass="18900" checksum="22CC3E8414ACFAC2" modified="2017-10-25" version="1">MEGINDSIKAAFEKVNGYRTIVHLFNVMWQLMSWTSNGINDDFILRKSLPAELTAAMKQLNESAAASPGSQQQQRVPSIGVMQQMFKSITSLSEMHHQQQLPQEQNSQQQAAVAAEVASAAKATTAARAKAKARTPAVATKAATEAKAAVAAKAAAEAATAAKPATTAAATAPARKKPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET92</accession>
    <name>A0A232ET92_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Anaphase-promoting complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_008256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002304">
        <property type="protein sequence ID" value="OXU21573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET92"/>
    <dbReference type="SMR" id="A0A232ET92"/>
    <dbReference type="STRING" id="543379.A0A232ET92"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000019">
        <property type="entry name" value="Anaphase-promoting complex subunit 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="189" mass="21525" checksum="5F35CA66B1DAC125" modified="2017-10-25" version="1">MSSKANASGASDPVQEELAGRVREVGNHAIWSLSSCKPGFGVDQLRDDITETYWQSDGQLPHLVNIQFRRKTTIRDICIYTDYKLDESYTPSRISIRAGTNFNDLQEVEVMDLSEPSGWVVIPIRDDNDRPIRTFMIQIAVISNHQNGRDTHMRQIKVHSPAEDILGPHSQLVPGRFLTNEFQRYATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETI3</accession>
    <name>A0A232ETI3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002272">
        <property type="protein sequence ID" value="OXU21661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETI3"/>
    <dbReference type="STRING" id="543379.A0A232ETI3"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="387" mass="45069" checksum="B8832D2EA4EF7119" modified="2017-10-25" version="1">MINKKVTDKLVTIVSTLLNIFLHIDYLFHSFKILKVFSRLFALYPLNSDCTKLEILYDNFVWLFIHFDFWVAAAATLVAIYKARSDLSLWLIAFSELIIIIEIIVAMILYRLQRSRLKILVHIFEDFVKDSDDSKLHLIRRNAKEHIKVFSILALLFIIVAIMYVYRALSTRPYQLLLSGYYPCTPDSLIIWLCILVIYSPSIFASDSIVAVLIFAAIIKLKKIRPRFRNIENHAQLVGCINEHQHIIWFVQEINYVIRLFVFKSIFCLAALQLGVGVILFMPNISVLTRIQFLLLFNVTIFRIYIYSYCAEILTKSGLDLGFAVYSSRWYDQRRKMVLAKSIIICRCQKPLLIAINDIIPALGMRYLACVVFVLDIFIYYHSTSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUK3</accession>
    <name>A0A232EUK3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002122">
        <property type="protein sequence ID" value="OXU22021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="11111" checksum="D4C3A23FCBA17A74" modified="2017-10-25" version="1">MMGSALCNPYRXXXXXXXXXXXXXXXXXFFFFFFQLKRCNRRKLMRSTITNGALTLRLSCLFITYICCSLKLSVCVTIIFRHVNSTRLPLISNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUP0</accession>
    <name>A0A232EUP0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2 5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2 5"/>
    <dbReference type="EMBL" id="NNAY01002103">
        <property type="protein sequence ID" value="OXU22080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUP0"/>
    <dbReference type="STRING" id="543379.A0A232EUP0"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU22080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="12983" checksum="18DFF60C6E081A87" modified="2017-10-25" version="1" fragment="single">PFSGCYNKFNGKGTYCCIVCEQELFSSKTKYDSGCGWPAFNEVLDQGRVKLIKDTSLVGGNLLLLMTNPQMIRTEVTCSKCNAHLGHVFNDGPKPNKKRFCINSAAIDFHAEIVNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVE2</accession>
    <name>A0A232EVE2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_007649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002007">
        <property type="protein sequence ID" value="OXU22329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVE2"/>
    <dbReference type="STRING" id="543379.A0A232EVE2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="140"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="612" mass="69762" checksum="10FCECC5C88A9F41" modified="2017-10-25" version="1" fragment="single">MDNKKRVQKENPANGANPLSTLFLWYTRHIFWESNRRDLTFDDIYDPLEADESERLGNQLERTRITMNQIQQVDLVGRKSYITEWNRELEKRRQLEYALNSEGKKILPKHAKASLSKALVRMFFWQNAWLALIQIVNFLVFVVVQPIFLGWVIDYFKVGQDVSTAARDKALLYVTWMILAKLGNVVMIHHGYRVSWLMGMRARVACCTLIYRKTLRLNKSVLDQTAAGQVVNLMSNDVSRFDQFFMFFNNVWITPIQIILIVYVMWDSIGVLLMVGIAILVVIAVPLQSIVIYTSKILRSKIAVLTDTRVQLMSELVAGIQVVKMYAWEKPFEKIVNKTRLAEMRKITATSHVRSIFLSSMVYTERTTLFATLVLFVLMGHHLTADISFVMATYFNILQLSIIYMMPSGLIAVGEASVSIKRIQEFLLLDEITTSKVEVLKIAERSTKDEIILTEKIKEVLQRDDARANLPVEINFHRVSANWVSGQLPPTLNELSFKVEAGSLCALAGTVGSGKSAILNLLLRELPLGAGIVSLRQKLDEEFSASKQQSGFHMDNANLKISYASQDAWMFSGTVRENILFGQEFDAERYGEVTEACALRRDFEQLPKGDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVN2</accession>
    <name>A0A232EVN2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001977">
        <property type="protein sequence ID" value="OXU22400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVN2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12477" checksum="8FA185C0C3094B15" modified="2017-10-25" version="1">MEADDETPPSVVQRHKLIKPKKQAFPRKPGFRFFGSMCKESIMDDSWSHARNVPNDCLDLEFGIYVYYKIKQFNVDLRKLLKDNKEKNITLVVKGEEFPANRAILMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVX0</accession>
    <name>A0A232EVX0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001936">
        <property type="protein sequence ID" value="OXU22508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVX0"/>
    <dbReference type="STRING" id="543379.A0A232EVX0"/>
    <dbReference type="OrthoDB" id="6628944at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="284" mass="32679" checksum="9FB6D41C1D9F744E" modified="2017-10-25" version="1">MPICSVNCCKNSKNTKDCEIQFHRFPKDQQIRDHWIKACNRESLNLENARICSIHFNQNCYVKKPDHLIVPGDTNVFVLSKTAAPTLHISDARDGIREANKVASEEIPVDSSKIFVTSDLEAIQYVAIDSEDREKNCFQHENEHLKKENADLKSDIEALNTANTQLKKKNDDLIIEMNKMTKKMQMHDRMIQNQVKEKVYEILQPIFTIGQIKKLLNLKVNEKSIKWNSDDIATAIALRSVTPKGYRYLRKKNYPLPALSTLRKKVAEIMIEPGVLEEVLSVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWS5</accession>
    <name>A0A232EWS5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001823">
        <property type="protein sequence ID" value="OXU22803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWS5"/>
    <dbReference type="STRING" id="543379.A0A232EWS5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF24">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="75136" checksum="0676CC4BE8188F94" modified="2017-10-25" version="1">MMSTKFGFYSRIIKLATKTYSHSKYDFKLQNSSHLPLACIYTLRKSSQKTHILSTTNDAQSQVSPSLKYSTKPIQVPPLMPEPPPPETDVFGSLGGLKYEKVELDEEELKEEERLKNIHGKVPRKFKPTPGQYAKMIKTYVEKGDLKSAEEVIEECKRNRDKPTDYMFSLLIRTFAIQGDIKKCYKYFSEMKARQYKIKPNVFTSLFNACANSPESDKALNYLERVQSYMNYKNVPLGHAHYNCLVKAYGRHNKLEMSYKILEEMMQKKLKIGISTINSLMYAANSDKESGLKHVLRIWQMMRHQRVPPDIFSYNLLFRAIRDCKFGNSTVNELLLESKEHNAIIVNNNRPDLLLYPPILSDLPLENIHRKDVPKIEGLISAPKDESSTSTHSESSDSTVSDVTDDYKEPLPASITSLDLDAILKQNKLILFGGLESLFEKMKNDRIEPTVKTLTYLIEIVPDSTTAEEMVIRYAKKNKIPLDVDFFNMLIKKRCIRGSKAAAKTVVDEIHKADLKPNIVTYGVLALSCSTSKESRDLLSTMKSTGHTINKYVADALLNNAFYKLDFGFILELMEHMRWERVRLDEETFEKLDQFQKKMSELIISKHRYAQTERFKLGFSKFNMRYKSWQEQMGRKIVAERDYKMETEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXP7</accession>
    <name>A0A232EXP7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001722">
        <property type="protein sequence ID" value="OXU23125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXP7"/>
    <dbReference type="STRING" id="543379.A0A232EXP7"/>
    <dbReference type="OrthoDB" id="9990815at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016028">
        <property type="term" value="C:rhabdomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13193">
        <property type="entry name" value="FERM_C_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17098">
        <property type="entry name" value="FERM_F1_FARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01220">
        <property type="entry name" value="PH1_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13235">
        <property type="entry name" value="PH2_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000040">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000046">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041788">
        <property type="entry name" value="FARP1/FARP2/FRMD7_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF5">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="48"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="9">
        <location>
            <begin position="602"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="842"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU23125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1122" mass="128439" checksum="B5CFFBE8143636D0" modified="2017-10-25" version="1">MSSDHEGRYGMSGGIGGKMPHSHSTPAGVDGGGSRTPPTTPRKAGKMLAFRVQMLDDSITMFQVQAKALGRVLFDQVCKQLHLLEADYFGLEYQEPNGTKYWLDLEKPVCRQVGLSLVDPLLRFCVKFYTPDPAQLEEEFTRYLFCLQIKRDLAQGLLQCNDNTAALMASYIVQAECGDYVIEDYPDHTYLSTYKFVPHQDNELERRIMENHKKHAGQSPAEADLNLLETARRCELYGMKMHPAKDHENVPLNLAVAHMGIIVFQHYTKINTFSWAKIRKISFKRKKFLIKLHPEGYGYYKDTVEFFFEGRNECKNFWKKCVENHGFFRCSVVKRVMRQKTRVLSRGSSFRYSGKTQKQIVEFVRDNYVKRQTFQRSNSFRQTSSGRALQGSEGGGYRGATSSSSLLGSSSISAHPLLPLGDPALETPALSLSCGSMTLDSPTTVTSVSMGGTNHRRDDTAMSYRTLTSIDVHSTATPYGQGQVASHATSHHQQQSQYQQQQQQTRISSTEDAEAEKPQESPKGSPQHQQQQPDTPQSTRKSENNNSVYTRGTTERRLANGSCGQEIGNLSPNELSPVKPMRNGDLGDDGDIRKTKRWPTDKAYFISKELLMTERTYKKDLEVINVWFREELSKEHESEGDYLVTLIELLADAHGPSLHEMESRLARWESNARHNIGDFLYNTLLNVLPLYDQYLENLLPVLEKFEYSIRTSKHFDQLCRDFEAQKHCYLPLTSFLLKPLQRLLHYNSIIDRLLDHYPKDHTDFEDCLAARDRLGETLLEGLTVLNQAVIYDISLYLEYLLYLVIDLNRFLWVFCHQENLVQLCELQRDISGFDNLVQEGRRFIRQGCLQKYSRKGFQQRMFFLFSDVLLYTFRSQQPTQSFRVHGQLPLKSMKIQENDNKTGSDFAFVIHGLGNQSLTVAASSEEEKERWLEDLNMAIAQTDSVEGKMPYLNLKTCILGSVDEVGDGTGMEGDRTSCGGAKASQRSNTTVHVCWHRNTSISYSDQLRAFQNQLSGFLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDDFPLASLPLLGYAVSQPADKDAINKDFVFKLQFKNHVYFFRAESDYTYGRWMEVIKSATQQSHVTTSYSLKEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYC7</accession>
    <name>A0A232EYC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-theta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014884</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. Required for correct subcellular localization of pgl-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001642">
        <property type="protein sequence ID" value="OXU23343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYC7"/>
    <dbReference type="SMR" id="A0A232EYC7"/>
    <dbReference type="STRING" id="543379.A0A232EYC7"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="552" mass="59923" checksum="B1ACC47574E85877" modified="2017-10-25" version="1">MALHVPKAPGVSQMLKDGVRYFSGLEEAVYRNITACKQFAQSVRTAYGPNGMNKMVINHLEKLFVTSDAATIIKELDVEHPAAKLLVLASEMQEAEVGDGTNFVIIFAGSLLEAAEELLRLGITTSEIVEGYEIALEKALEELPKLVVHEAKDHKDIEQIKAGIKTSIMSKQYGKEDFITELVCKACTSILPANASNIKTTFAVDNVRVCKILGSGLHSSQVVQGMVFKRQVEGELTKVLNAKIAVYTCAVDITQTETKGTVLIKSADELMNFSRGEESLLESQIKAIADSGATVVVSGGKFGDMALYYVNKYNMMAVRIPSKFDLRRLCKAIGATALPKLIQPSKEELGYADTVHVDELGDTNVVVFQLHGQESRISTVIVRGSTDNYMDDIERAIDDGVNTFKAITRDGRFLPGAGATEIELASRISAFADTIPGLEQYAVRKFSTALEVFPKTLSENSGTQAQELLSKLYAAHKEGKVNHGFDIESTGVATIVDAEKAGILDLYLTKLWAIKYAVNAACTILKIDQIIMAKRAGGPKPRAGKANSDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYF2</accession>
    <name>A0A232EYF2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001627">
        <property type="protein sequence ID" value="OXU23391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYF2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="9645" checksum="382F33BB1D905EB7" modified="2017-10-25" version="1">MFWRDFPSRPFASLLLGGDSSREQGFGVPRGVSSALADGGATVDRKELNTSISALETQLADNMEENNTLRDELQQTQQLLKVSSCSPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYN0</accession>
    <name>A0A232EYN0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L15, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001561">
        <property type="protein sequence ID" value="OXU23596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYN0"/>
    <dbReference type="STRING" id="543379.A0A232EYN0"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="7">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="296" mass="33843" checksum="2B072F633BD66286" modified="2017-10-25" version="1">MAQSGLVGRELALTMLRVLPRVCLGNLRPNPGSRTKKKRGRGQHGGDKHGFGNKGSGQRQNYMRTGYETGNTPFYLRFGFEPYYKGHHLRRQYPPMSLEQLQLLIDTNRIDTSKPIDLTTLVNTGIIPIKPDWKHYGIHLTDAGADLFQTKINIEVQWTSEPVIAAIERNGGVIRTAFYDMNSVYAAVDPERHFKRGEPIPRRMLPPADCLEYYSSAETRGYLADPEKISEERLALAQKYGYELPKIEDDPDYDMLNARKDPRQIFYGLEPGWVISLKDKAILKPKADYLKEYYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYR0</accession>
    <name>A0A232EYR0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001589">
        <property type="protein sequence ID" value="OXU23501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYR0"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9955" checksum="B85501D50A41C52D" modified="2017-10-25" version="1" fragment="single">HPQSQDQTERFPCTDCPSVFSRKCNLYYHRKYECGQPPRFQCPYCQYRTRHQSNVRAHVRRIHAGREVYFIDLGRQGFENLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ26</accession>
    <name>A0A232EZ26_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001577">
        <property type="protein sequence ID" value="OXU23537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ26"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012308291" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="8031" checksum="E6E703CB9D01D7A5" modified="2017-10-25" version="1">MFKFVILLCACIAAASAGYLGAAPIAYSAPLAYSAPLPIAAPAPILRADLPIAAPAPILRAGLPIAAPLFRAPYASVAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZK2</accession>
    <name>A0A232EZK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001516">
        <property type="protein sequence ID" value="OXU23723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EZK2"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="510"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="955" mass="107834" checksum="BE401DCDC0D041F1" modified="2017-10-25" version="1">MAETCWYNSKRMRLDDGCNNNHNSTKEKENEKWSCSGDTSLVEPEILEDMGVGMLADGEASRESLQTLKTQECTISPKNFDKLKPASTLYESQETYKSNSFEKENIDRLDPFENEDAVNFCAINNESGYASRVENDNFVEAKENFSKEDSNDAVDKPGMDQFYLFRRKKKLSVIGEDKFNKLSDEMILMILKWLPKKCLVRSMLVCKRWCQIARDEALWTRLDLGSKVLAGGTLGHILPRGVQILRLAQAEIANPAFLSNSDISFEDYTCKLQYLDLSMAVVSADFLADLLKKCKYLKKLSLEKCTLNTTSCEAISKNEDLEILNLTMCXLGSKVLAGGTLGHILPRGVQILRLAQAEIANPASLSNIVXINNESGYASRVENDNFVEAKENFSKEDSNDAVDKPGMDQFYLFRRKKKLSVIGEDKFNKLSDEMIVMILKWLPKKCLVRSMLVCKRRCQIVRDEALVENDNFVEAKENFSKEDSNDAVDKPGMDQFYLFRRKKKLSVIGEDKFNKLSDEMILMILKWLPKKCLVRSMLVCKRWCQIARDEALWTRLDLGSKVLAGGTLGHILPRGVQILRLAQAEIANPAFLSNSDISFEDYTCKLQYLDLSMAVVSADFLADLLKKCKYLKKLSLEKCTLNTTSCEAISKNEDLEILNLTMCEGMNLKCVKSIIKLTSKVLAGGTLGHILPRGVQILRLAQAEIANPASLSNSDISFEDYTCKLLYLDLSMAVVSADFMADFLKKCKYLKKLSLEKCTLNTTSCEAISKNEDLEILNLTMCEGMNLKCVKSIIKLTRLTSLNMAWCALDSESMVYLCQSLPFSIKRLNIAGCRKTLTDDNIKDLVQCCPNLVELDLSDCTMLTINTVHSLMNLGELEHLSLSRCYSIPTATHLRLALLPRLKCLDIFGLLSEEYLKTFMAKCDKVVINKFPYSAIARPTVGVRRTSIWGHRVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZL5</accession>
    <name>A0A232EZL5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001518">
        <property type="protein sequence ID" value="OXU23710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZL5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="12759" checksum="19FCB3B9274D68AB" modified="2017-10-25" version="1">MEDAWTGLVEIIGATRSVDVSCVLFSELSREPLLRAKGYYNVENVVTSFTGFIAPGYGYLRISPLATQKLVDVIHFEKKLVASFALETFPKVSALIASDRRQKAAKKNLRLREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZP0</accession>
    <name>A0A232EZP0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT and BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001458">
        <property type="protein sequence ID" value="OXU23904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZP0"/>
    <dbReference type="STRING" id="543379.A0A232EZP0"/>
    <dbReference type="OrthoDB" id="550012at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045902">
        <property type="entry name" value="SANBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021777">
        <property type="entry name" value="SANBR_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20946">
        <property type="entry name" value="SANT AND BTB DOMAIN REGULATOR OF CLASS SWITCH RECOMBINATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20946:SF0">
        <property type="entry name" value="SANT AND BTB DOMAIN REGULATOR OF CLASS SWITCH RECOMBINATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11822">
        <property type="entry name" value="BTB_SANBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT and BTB" evidence="2">
        <location>
            <begin position="270"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="849" mass="97467" checksum="E8C9AEE9C79B94DF" modified="2017-10-25" version="1">MYPNLFKQLNLPKLYNDVSKPSDISSQIEACERKLSEKMHSREEEEHYPELSVKTFFDFMRTAYQVNESFEELASTLTANSEIDWSALAKVSLNLGGKDSELKIEDGVKESKDVDTFIGKESSTLLLTSETQSDPLNADQIECSVTYQQCSDNNQSLKDEDSTEVHFINKSKSLSAISYTENKKESLLSKVMKRCLSDVLHEGLLDSVLPYMLPKPTFSQPIIKNSAITEPRKVASVTNGFENRVVNAIVGSKEKDKEKSKQKKCMETEVEIHVCDEAKNVKKDFRCPQRLLVQKMCYFADVTAGQKLEEMDISVHCDIVIFDWLMRWVKKDIIKKSEWPILEANNVVPIMVSASFLQMEPLLDNCLTYCHNNMSDILKTTTILTCLNDTLLTRLADLFTNADVEAIKDKKDKIQSRLFCKLIMTLANPKPDNKRGHFGSLATLFKCLKCEKNVVRSVSNLVPCVPSNMKIDRKGNLHSKHTRDMTWNLNDYIVNLRSELRSWRKVYWRLWGDCHFLFCRQCGIYFPINQMDWCSYHPENPQFFINEQQRATPFPLGRYPCCSQRAYRFQAITNMDGCRFREHVPEIISEKDENIINVFLAYREIISIEAPQLFFPEKITRLVARDPLLPPGKLACKETFWWEGIEIVPPRPKLGLLGKIWGGSGLRKPCQTLQKAVKKVRRQVSQITDISSAASSETFSDEDDEASHDCNSSFDEESLDSDESGDWETTEFASKKKKKTKSSILRRCEGMGSWSQHLSIRYNQDNQRDFEEKAAAQMVALLTKRTILERNLRPKSHSIGKYNIWNNNTQPIGGSYIRLEAEFLNQYAQNNKSKNTILTKGTTRIKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F089</accession>
    <name>A0A232F089_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRKCA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein interacting with C kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein kinase C-alpha-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSAR_009013</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">Alberta</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition. Interacts with SORCS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
            <location evidence="21">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001418">
        <property type="protein sequence ID" value="OXU24045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F089"/>
    <dbReference type="STRING" id="543379.A0A232F089"/>
    <dbReference type="OrthoDB" id="5917245at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098842">
        <property type="term" value="C:postsynaptic early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097062">
        <property type="term" value="P:dendritic spine maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07659">
        <property type="entry name" value="BAR_PICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06722">
        <property type="entry name" value="PDZ_PICK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000023">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000073">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037959">
        <property type="entry name" value="PICK1_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF1">
        <property type="entry name" value="PRKCA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="95"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="AH" evidence="26">
        <location>
            <begin position="217"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OXU24045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="613" mass="68431" checksum="B695C9CC25146BFE" modified="2017-10-25" version="1">MMDYEDDFLFEEDKMLMCETTPLNKPLQLSESLDGASLVDISVCKSTVPLAHVESHQLNMMEDRIPGVELVFQDQSTCLSQHHIDQMGMTITSGNVVIEKDNNNLIGISIGGGAPLCPCLYIVQVFDNTPAAQDGTLEAGDELVAVNGECLKGKTKVEVAKMIQACDTKVSIIYNKLHADVRQGRTLEIVLKKVKHRLVESMGNTTADALGLSRAILCNDTLVQRLTALERTENLYKGLVSHAKSVLHAFFDLFQIYKIFGDAFASMGVKEPQPRASEAFTKFGEAHRQMEKLGIDMLKTVKPILSDLGTYLNKAIPDTRMTISKYADAKFEYLSYCLKVKEMDDEEQSYLAIQEPLYRVETGNYEYRLVLRCRQNARTKFAKLRSDVLVKLELLDNKHVEHVVTQLQRFSAGLADYYVNISKLISENMLFPVEIDLCQSAFQYKPSGQVTAYVDEEEEEEGASGYDPSKILDFDVAEEAIPTKTSNKNANSSTEAGSSKGTESKGLSDLSDLVDLSGFSDLNEKFEKLLLLENKKISEVEPLISLEKKTKNITKTKDEKNEPLLFLDDKCKDTSLLVLESSEKSETTSKSNASESLLFLDTLDEPLINIETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0B9</accession>
    <name>A0A232F0B9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001428">
        <property type="protein sequence ID" value="OXU24003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0B9"/>
    <dbReference type="STRING" id="543379.A0A232F0B9"/>
    <dbReference type="OrthoDB" id="7543230at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF7">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="352"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="415" mass="47357" checksum="64A678B998875EA5" modified="2017-10-25" version="1">MQSALIKMPESGAVYQPTTVGYAYDTRDGSRLGIRSSFSRIMSRHKFSTRNWLEWVLFSVAVAAFIAGLTTMLVNLVSADDQASTPKKIDGTTPAKDSNTEIKEHSEDGARASIAVGAAMMLLGLLMGFIWAWLRFFRRGKSPRETVCNMEEERNSKLSNSSEASPICTTLSSDVRKYKLKLHVTTDQREFIFKFISDNPEIITHSSTKENERALWKELVTKLNYLKPERSIDNWKNFWQRWQASVGSKPESILTPLDCKLKVFIAKIMNNSETIEREDSRARYTIKEIEDTIRDIEKERSKQQLQIDENDYKIEIYKINIKRTNCTVKSNVLCLGRRKFLKNLPCNWTGGYRWSTALILSITLGGFGADRFYLGHWQEGIGKLFSFGGLGVWTLIDVMLISMRYLGPADGSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F198</accession>
    <name>A0A232F198_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001330">
        <property type="protein sequence ID" value="OXU24339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F198"/>
    <dbReference type="STRING" id="543379.A0A232F198"/>
    <dbReference type="OrthoDB" id="8948150at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU24339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="376" mass="43025" checksum="A8084DBF4B666316" modified="2017-10-25" version="1">MGKGRRCIVPSCRYLSGKNDLEKRAMFKIPKDEEKARIWAAAIPGITHPLTTYQTVCEKHFESWFIHRFYEKGTNIMRSRLHNKAVPTIFDTENVPNQNVILLRQHSEKQSRKAPKKGISSSNISEKSTLEVSSAFSNNSLSNQTASNETSLQEIVKDLSLSEKLLMDIKQEMFPFSEDGVKHEDIDERVKTESDVDTKEITAYEHLHKNFSFYITQLPENWNLTRLALSTDQVFVFSKECTVCENGALIVMNEKSIVINKHGDIHYSIHGKIVSVDSSYTPSVINDIDTLLDVVLKFDEVKVCQGICTNEFEVDKDFVLQKDDLGYSRHIHCSLIADKQQCDACWEYSQYLLALMVNNTPVLGNETARFYNQIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F299</accession>
    <name>A0A232F299_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_004287</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01001213">
        <property type="protein sequence ID" value="OXU24712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F299"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000012">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="299"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1362"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1370"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1380"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1397"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU24712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1706" mass="193170" checksum="8DAF868A5305C421" modified="2017-10-25" version="1">MSKYQKSGFRMTVKHLDPKSLTFSVFTADDIKNLSVKKITTPDSFNVLGHPLVGGLHDPALGPLTDTSDPCRTCGCNVYKCTGHFGHIDLPMPVINPLFHKALQTLLKLSCLNCFSLQIPPLAKLLLSAKLTLLQRGYFSHIEIFEQEVMSQIADSNDGQGADIEYVRDQINAGLQKVLEVTRFKKSYKIADFNTKNTNMQWHLCVDSFLKQYSAGKKCIHCHEAISKITVLKNKIMIQRVLQNADKNESQGVVHKLEQVFLMPDQTKEYMQKLWQNEEETLKVIFPCLNNLTIKNPTDVFFFEVIPVLPPIVRPVNFLDGQLIEHPQTQVYRSIIINCLTLRNIIQAIQDGDTSRLPDAGKLVYNNTRGSSAIEKLHNAWQELQANVDHLIDRDMSKTTESANCQGLKQVIEKKQGVIRMHMMGKRVNYAARSVITPDPNLNIDEIGIPEAFATKLTYPVPVTPWNVAELRQLILNGPDVHPGAVMIEGDDGFITRLTAENYVQREAIAKRLLTVTEKANKFFHGVKIVHRHLQNGDMLLLNRQPTLHKPSIMAHKARILKGEKTLRLHYANCKAYNADFDGDEMNAHFPQNELARAEGYYIANVSNQYLVPKDGTPLSGLIQDHMIAGVRLSLRGKFFEKEDYMQLVFSALSVIQGNLILLPPAIIKPIPMWSGKQVISTIIINIIPRGKALINLTAGAKIGAHEWQVTKPRPWKCGEEFKNPKTMSESEVIIRNGELLCGILDKKHYGATPFGLIHCVFELYGGTTSSRLLSAFGKVFQSYLQRIGFTLGIEDILVKQKADKKRTEIISECRKIGESIHKSILEVPEDTPMEIVTAKMEESYWSNPKFRAQVDRKYKTALDVYTNNINKTCLPAGLIKTFPENNLQLMVQSGAKGSTVNTMQISCLLGQIELEGKRPPLMISGKSLPSFPAYDPAPRAGGFIDGRFMTGIQPQEFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHMEGLMINYDATVRDSDGSLVQIYYGEDGLDILKSRFLNDEQFEFLVENRNAIADEQLLKQLKANADPQKISKLVKKIHKWEKRHGSSLVKNRTSAFTKFSAEHAKPDSSKNKIIIPACGRSKASLSLMKKWIRTDDETKNMYRSQCDRCPDPLTAKYRQDLDFGVLSEKLESLLDNYLKKKSGSFTTSIGKEELREVLCAKVMNTLCPPGEPVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMMASKNIKTPSMEIPFKQDLPNLTKQANKVRLKLTKCYIANVLKHIKVERKLVHQPQRQMQYTITVEYLPHKYYKNEFGVHPKDIITKTERLFFREIFRDIKKAAKSTGSIVYFNEEKRQTKNEDSKLDEDDAGAEDEPKSRGRFDLGEMHESSDEEEVADDADATTARSVSRHQENREYDDPEEEEEEPEEADNDNENENGKVNNAPAANKDDDDNFRVSMHGINRIQYEQRKLDIVNMYVHALDYDYDAEKNQWCKLKFWLPIKLTNIDMPTILRNVANKVVLWETPAIKRAFTFQNPSGETILKTDGINVVEMFKYNEILDLHRLYSNDIYGISQTYGIEAANRVIVKEVKDVFKMYGITVDTRHLSLIADYMTFEGRFQPLSRKGMEDSASPLQQMSFESSLNFLKNATLQGKNDDLTSPSSRLMLGQPCNSGTGAFSLMVDIQQQISQLHLQPLPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2T5</accession>
    <name>A0A232F2T5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001190">
        <property type="protein sequence ID" value="OXU24800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2T5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12325" checksum="86ED23F4D38FE0D4" modified="2017-10-25" version="1">MNHLEFFLVIIKWRGSAKKASLRNKRSRGTRDTIYFYIGVQVPQGALPSLYSCSATSKTPNQRVTTKKSLIFRETVGDDVDTAHPGHQEPSRALPSQYSCSATDLPHKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F387</accession>
    <name>A0A232F387_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001149">
        <property type="protein sequence ID" value="OXU24979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F387"/>
    <dbReference type="STRING" id="543379.A0A232F387"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="17064" checksum="4571537792F75388" modified="2017-10-25" version="1">MRLMQRLAISGLLSVMLIVLLTGTFVTRRDLTSVVDRGVGPEERNEQINPAWVQDNIVLDPEYQQQKLAFKAVTTPRSNVVVNVRHRHPPIEEPVLELEQPDAAQALGPYVVKQPNPALDDVTHQRREKVKEVRALLFVLSFFSLTGGCAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F395</accession>
    <name>A0A232F395_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001155">
        <property type="protein sequence ID" value="OXU24960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F395"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="11744" checksum="16C52FA6D7601CEA" modified="2017-10-25" version="1">MLRIDFEEARGRKKLWKWRWVAKEENFYILDKWLSIREREDRFHLVKKARELEERKTVKGEKIKVRLENEKIVEEEEGKENEKGADTNEKIEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3Q0</accession>
    <name>A0A232F3Q0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">chymotrypsin</fullName>
            <ecNumber evidence="8">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01001042">
        <property type="protein sequence ID" value="OXU25381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3Q0"/>
    <dbReference type="STRING" id="543379.A0A232F3Q0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="59"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="293"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="518" mass="56261" checksum="A940DEF6633E0202" modified="2017-10-25" version="1">MYRFVSVYAKILGEIVYKQINNRSEAHQSSSTQLTMQAFVAILLLGLTATAYAGPTSRIVGGGKAADGKYPYQVQLRDGGRFLCGGSIIGTRYILTAAHCVDGRDASKMTILAGTNILGDEKTGKVYQADALIPHPKYGALLIVKNDVALIRLTEDIEYTPKIKPIALPTSDYDQFDKTVVLSGWGKTSTADPPATNLQEIQLNVLTKLKCKLFWIFVKPGHICTLNQKGEGACNISISEILAAHWLTKVAFKSESSPSVCPVLVVHLMSSQGSSHTLTGLRLKWSSGPTSRVVGGIEAVDGKYPYQVLLKLYGDFFCSGSILDSRYILTAAHCLVGKTVYGMTVTVGTNTKSYNTGDAYEVEKLIVHEGFDRFLAINDIALIRLKKNITFSEKARAVKLPSEDVKASGTSVKLSGWGHVGKLMPSSNVLMEVELNIISNEKCNESWKKIKDTQICTLTKAGEGACNEDSGGPLTTENNVQVGIVSYGEACAVGIPDVYTRTYSFLDWIRKNSESPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F422</accession>
    <name>A0A232F422_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001063">
        <property type="protein sequence ID" value="OXU25279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F422"/>
    <dbReference type="STRING" id="543379.A0A232F422"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000351">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 27C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000427">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 27C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="305" mass="33393" checksum="434EC6B27098E28C" modified="2017-10-25" version="1">MRVKNEMDDDEKGKLFVGGLSWETTQENLQRYFSRYGEVIDCVVMKNSESGRSRGFGFVTFSDPSNVGLVLQNGPHQLDGRTIDPKPCNPRTLQKPKRSGGFPKVFLGGLPSNVTETDLRSFFQRFGKVMEVVIMYDQEKKKSRGFGFLSFEDEDAVDRCVGEHFVNLNGKQVEIKRAEPRDSSSKMNDSHQGQWGPPQQGPPMGMAGNMGPMGGPNGQMGGPMMGGPMGPPGNMMQQYQGWGTNPQTGGYAGYSTQYNAQGWGAPPGPPQQQQIPPPPPHQWGSSYNVQPAAANQAYGSYGQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4A0</accession>
    <name>A0A232F4A0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neural proliferation differentiation and control protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001060">
        <property type="protein sequence ID" value="OXU25298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4A0"/>
    <dbReference type="STRING" id="543379.A0A232F4A0"/>
    <dbReference type="OrthoDB" id="6270617at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009635">
        <property type="entry name" value="NPDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352:SF2">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06809">
        <property type="entry name" value="NPDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646948" description="Neural proliferation differentiation and control protein 1" evidence="3">
        <location>
            <begin position="29"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="60607" checksum="974C91D262F38622" modified="2017-10-25" version="1">MTRIRFKGLRLSAHLLLALAGLLGLATAELELYQDVQPKLTPKVKLERLVRFLESKSHGSGLHQQPLPLSAHQHQPLPPPHEPLPQQMALQQQEELEELEQLELHRKQQAALHRKQQQLYRKHQEHLLDLARQKQRGILRDDLPERPNIIDVLQWQAADPLEYVKELERQRLLPYLEYEPPRIKQYSLEDEARARLLPQLNKDPLLDYPETQFMDLDQRARQLQVNAPRMIQEAHRRRPAFTFRFNQPEPHRETEPKPFAFKPNDPRFYEEDIGDREPLEETHRSHAVDHHHDLVDELPMHDGHVVEDNRHVPMHFEPSSPKPRPVKPTPKRPREEHNRDHELIMPRTGVVDMSMMPEPHRRAQQDPLVVSLDNKVNNDIYFIAIVAGCSAAAMFALVLISLTWCRLQRVSKAAADVEYPAYGVTGPNKDISPSGDQRLAQSAQMYHFQHQKQQIIAMEKASATRDPGSVSEAESDEENEEGDYTVYECPGLAPTGEMEVKNPLFHDDPTPATPAKSSKRNDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F562</accession>
    <name>A0A232F562_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_010178</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000983">
        <property type="protein sequence ID" value="OXU25619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F562"/>
    <dbReference type="STRING" id="543379.A0A232F562"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="614"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="638"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU25619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="694" mass="80705" checksum="B4F7578A4BE883F6" modified="2017-10-25" version="1">MKRLVTVPEAKMEVDTNVCQILEQADEGEEIILEPEGGCEEGEEIEEIVEIIEEIEEVEENEEVEDVEELEEVEQIEQLEEEEEIQEAPIVKTTNGTYVHKENYMNNNQKNKVNTIFQQPSSSQEKSNIQVHYDASADWEDDEYEQEEQDNSEEHIVQESASNSQDFNTYATYSNGGDDEIVHTDEGTQNSQTQDSYEHSLNQENSVDSQQHKIVQNPENNLIYTVLEPKKQAKQASQDTRSSDLEFVEVQRYKDDNLPEDGTIYYAVNDDGTYVQAVEGNQQYQFVNQEQMETENQEWEAANQNAEEQPEQAEQDQIFLHEDEDGQLYFKNEHGQLQPVYLTPDGSYAIVENSSDEQDSQEGPTRMEEEPVDTDNYVLPDLDLKPYTSSKKQRLNDPSQDDDDSTVTISLIISEDENGQKRTQVIIPTAADSKCNICNKTFKTSLQLLKHNRLKHAREEDITTRNFPCDLCPKRFTDQNSLARHRKTHTEARPFQCLECHKSFPTANTLRKHLAMHNPDSQPLPCIYCGRRFSDKISLQKHEQSHLAGEKRTHVCDICQKCFSNINDLNIHKKNHDPDRKFDCEVCGREFNRLNNLQRHMMVHQQQGANEEILSCNVCGITYKFSSSLTRHMVTTHMNPEKLRQQAEEQRRKRESNYRRYLENRKTYETQQPKRPYRRSTGRLMDDQDDDEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5B0</accession>
    <name>A0A232F5B0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000907">
        <property type="protein sequence ID" value="OXU25981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5B0"/>
    <dbReference type="STRING" id="543379.A0A232F5B0"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="414"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="563" mass="65919" checksum="2AC85EDDC454D54B" modified="2017-10-25" version="1">MDLMGLVPNWESDHDKGGPKIVHDCREPPDEDEVDNLIKGNDLFSRFSRWVTRKRILSTNHYYAKACLKSSTAVKFEISRHLQDFPYMIHPFSPFRIFWDITMTIFTLASLIATPFLNAFFFNDQLRSLPFIMIIDFVMLKYIRSYFIFDILSGVPAEVFDFMAHGDEHINWYCSTFNFVKIFRVRNLICCIRQFHKSYHMSFHNVKILELTIIIIISIHWSACLVYYVPMVVQKFDGFDDAVSKSWILSASMKKRNSRLKKYILCLNRATISLVSSEHYLDVTTAEDMIMNFLLAVFGKLGFVYLLCAYCLNEINIKHSHVTLANLFSAQFLQLMTTYHSSDKERLRLLQQLQEYVQYKELPRVTQKRLMVYCNYWYKKNFNRDRRIHAQVSEPLREELILHNYTSLLEMVDLFKYLPRAAIVELVKFIRTEIHLVNDVIVKSGTRGDCLFFVGSGTVAVYTSLGKEVCHLEDGSYFGEIALVMENEQRVASVVAVETCEILVVPREAFQQVVAPYPNLLSRLQKVALERLDKTLLLDEIYKLEDPRPRYINISNIRGKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F610</accession>
    <name>A0A232F610_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="13">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_011083</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000922">
        <property type="protein sequence ID" value="OXU25888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F610"/>
    <dbReference type="SMR" id="A0A232F610"/>
    <dbReference type="STRING" id="543379.A0A232F610"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="15">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU25888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="142" mass="15478" checksum="9D6503EADEBF093C" modified="2017-10-25" version="1">MSIGVPIKVLHEAEGHIITCETNTGEVYRGKLIEAEDNMNCQMQNITVTYRDGRVAQLENVYIRGSKIRFLILPDMLKNAPMFKRPGGKGSGTAGRGKSAILRAQARGRGRGQNQRGRGTGSAPWLNQQNQTSAPQTGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F688</accession>
    <name>A0A232F688_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000811">
        <property type="protein sequence ID" value="OXU26376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F688"/>
    <dbReference type="STRING" id="543379.A0A232F688"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="91" mass="10136" checksum="0C4AAC009AB6DBA3" modified="2017-10-25" version="1">MIFYKAGLFFTNIGKEDPKALSSLSTVLHGTSRPIRSQNIKKNSMSESSSDIMELEEGILLRRSGIIKKPTSNPHYNNNIHLACLSIETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6V1</accession>
    <name>A0A232F6V1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000857">
        <property type="protein sequence ID" value="OXU26183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6V1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9503" checksum="4495AAE879E658C6" modified="2017-10-25" version="1">MKFQLLHHGTTLVHWECEGGASRTALSQMVKSNIVKSLGEIEVFFKEMPARNRYNSSANGNKWSIISGRRRSRERFPVYDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7F5</accession>
    <name>A0A232F7F5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_005548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000770">
        <property type="protein sequence ID" value="OXU26605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7F5"/>
    <dbReference type="STRING" id="543379.A0A232F7F5"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="653" mass="73315" checksum="0A28616197AB3FE9" modified="2017-10-25" version="1">MSVVNFIVVPTKNAINEAFKGREPWEIVGMTSTSVLAAVWLYNFVHDDDESIYERMRKMAMRLLRCCPKIRDKIDGELKKLNEEFERETINRTKGVPYVTSLPAQGIDREQIIKLVERSVYLGNYDWKNGRVSGCVYRNAESELKDLVKEVYSLASLTNPLHPDVFPGVCKMEAEVVRISCRLFGGDDNSCGTMTTGGTESILLACKAFRDYAREYKGIKKPEMVVPVTAHSAFDKAAQFLKIRMRLVPVNPDSLTVSIEGMKRAINRNTVLEDSLNPREDPKIRVEGDVRPDDAEATNEDTLTVRDTLRVSYVFRGTFSEVSALKISDAIIPYSGKFAKIFNIPNISRLKIQCTLFLQKLVCSAPNFPYGTMDNIERISRLGLEHDIPVHVDACLGGFLVCFMREAGYTLPDFDFRLSGVSSISADTHKYGYAPKGSSVILYRHKKYRHHQFTISTDWPGGIYGSPTVNGSRAGGIIAACWATMMYFGMEGYVKATKDIIDTTQYIERELRGMNNIYVFGTPMTSVIAVGSHDFGIYRLSQALNARGWNLNTLQFPSAIHICVTHVHTEPGVAQQFVDDVRFELEKIMQTPEEEAEGIYALYGSAQTIPDRSVVGEITKSFIDSMYYTPPYGTETLDVQLDARHQNSDSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7J9</accession>
    <name>A0A232F7J9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Runt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000835">
        <property type="protein sequence ID" value="OXU26267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7J9"/>
    <dbReference type="STRING" id="543379.A0A232F7J9"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="364" mass="39033" checksum="09964B3ED7881ABC" modified="2017-10-25" version="1">MHLPEGPIGMENHFSAIHDALRACHGDLVQTGSPAILCSPLPSHWRSNKSLPVAFKVVALDEVSDGTLVTISAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSLTIQISSVPFQVATYTKAIKVTVDGPREPRSKSNYQYGPGFPALGLLNPWLDAAYFSHAWHLPHPALAKGSIGMSHTDLFGPSFPPAVLPTGYPLTDHNVKYNSTTAADFASSMSHKSSSIHSMTPPPTTTPTVPLSNVVLPNSPSRTPPRSPSDSGSESAPEEVVRSAFAPIKSNSNASSIHVPTSSSSPDRLSNNNNSKRPIEGTRCELKAPKALISHRTKTLGKRSPSPTKIQPTSPAVKSVWRPYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8A1</accession>
    <name>A0A232F8A1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000705">
        <property type="protein sequence ID" value="OXU26885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8A1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="47" mass="5475" checksum="1C554F70462B5A73" modified="2017-10-25" version="1">MERKKEKALLVLAIYSWNNGAQRVVLTIAYLALSTEEILQYRHSIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8F3</accession>
    <name>A0A232F8F3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNAAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000730">
        <property type="protein sequence ID" value="OXU26770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8F3"/>
    <dbReference type="STRING" id="543379.A0A232F8F3"/>
    <dbReference type="OrthoDB" id="1904536at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000166">
        <property type="entry name" value="Dynein assembly factor 1, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="221" mass="26014" checksum="8A09B3731CD63E85" modified="2017-10-25" version="1" fragment="single">MADSKNNSVVKHNMLNYQEKVLKSIEKQLDSKLFRAEIENQIKKTVDFRSSEKPQNEISLFNKKKNEIRMSEDIIKKHCREHKLYETPSLNDVLYLHYKGYSFIENLENYTGLKCLWLENNCIQAIKNLDNQIQLRCLFLHHNLIKKIENLEHLKKLDTLNISYNLISKIENLGSLNNLNSLNVSHNYLQNAEDIEHVRVLDSVSILDISYNRIDDLQVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8K3</accession>
    <name>A0A232F8K3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000759">
        <property type="protein sequence ID" value="OXU26647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8K3"/>
    <dbReference type="STRING" id="543379.A0A232F8K3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34674" checksum="9DB69BABF2712FD3" modified="2017-10-25" version="1">MDSECHPNCEYDRQTKMAERNVIGSLSSVNVDNLWTINNFSNHLNAETNEFLRSPYFHVDKYKWNILLYMNDVGIGPQDFITVLINVKMERPFELRTQIKFSLINSRNEEINIKNSRHGKLVIRCNLAFLDQTVNLPSDKRTLTDVKLHTANGEDIHAHKAILAANSPVFYAMFQHDTTENQENVIKIADCDFDALTELIRFMYTGTIRNLENIAQDLLVTAGKYNMKELKLLTLKTVLDYIFMLRLHKFTDLEEDVRKYIHENIKDAIYSTEFISMKQEYPNLLLDLLCYSVEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8N7</accession>
    <name>A0A232F8N7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_008793</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000686">
        <property type="protein sequence ID" value="OXU26972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8N7"/>
    <dbReference type="STRING" id="543379.A0A232F8N7"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU26972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="284" mass="32646" checksum="5F6B63E94C3124B0" modified="2017-10-25" version="1">MASLPKRKLPTASQAEILRSHQRDNDFVLTMSETITDLLHRYDLYRNFSRFIKSEVPAKLFYFIVTSGLGNQTLGEEYTGIVQANLHARKVPSLMTRVLAAILECFGEQMLLKLLEKLQITINKPNSDLTPQAKSFLNIFLNRTRTVIPILILAHRGLFYIYGRYYSIGRRLTKVDYVKVYGPRPHSSVSWGLRILGFATVAQCLFRLWQSRNMTEEIMTEAKEFESVSSSRCQLCLEKISDTTTPCGHLFCWSCLAEWLRARNRCPLCRESVAPSRIIPLMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F932</accession>
    <name>A0A232F932_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000620">
        <property type="protein sequence ID" value="OXU27361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F932"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="486" mass="54519" checksum="AC8B7FD2CC7F1E47" modified="2017-10-25" version="1">MTEEDRSALTNDEPTVKIVKKVVQDDGENETTPKEIDIAIKVYRRRWFMLCLYIFYTALVAAQWIQYSIIANIIQRYYDVSSFAVDCTSMIFMFYYGIFIFPVSYLSDRIGLRWTIIAGSALCCVGSWIKILSVDPDKFYVALIGQSVIAVSLVFVLPLPGRVAAEWFAADELSTATSLGIFGPQLGVSVSFLLPPVVVKNHENVADIGTDLAFMFWFVAVAATLNLALILLFFQNQPKLPPNKTVALQKMKKSEKAEPFVKPMKRLMTNQSFLILCNSYGLNVGILNALGTLLNQLYLIHFKNGEEDAGRIGLLIILTGMFGSITFGIILDKTHKFKETTVIVYFLTLCGQILFAIAIFLEVKWMVYASSVFLGFFMSGYLMLGYELAAEYTYPESEFYSAGVLNITNNVYGIILVLILEVMLEHYGDVPVHVIFCVALLVGLIMTIMTKDEQRRQEAQKAGNKSLYQNVPVDEANIKEIKDIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9F6</accession>
    <name>A0A232F9F6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 5B, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000665">
        <property type="protein sequence ID" value="OXU27100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9F6"/>
    <dbReference type="STRING" id="543379.A0A232F9F6"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13956" checksum="2F056316B7E03882" modified="2017-10-25" version="1">MASLCRRAIFQVARRPLHMSACRSMEEKMADPLDHATGLEKAEMLAELAGNDDPFDTKVMKRGPGTKECPNLVGSFFKSRLVGCICEEDQLHINWMWLHKGKPRRCECGHWFKLVERTPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9U9</accession>
    <name>A0A232F9U9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000647">
        <property type="protein sequence ID" value="OXU27203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9U9"/>
    <dbReference type="STRING" id="543379.A0A232F9U9"/>
    <dbReference type="OrthoDB" id="7699767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="312"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="395" mass="45902" checksum="0E658B4B4F22E6A6" modified="2017-10-25" version="1">MLASKSHSATTNAKQGRVDDSFSKQISYQKGSRAIETNAKLVSMLAKDNLPFRTVEKEGFLEFIKALNLFYKPPSRKSITKLVEEKYEYLGGLTKEELSKVDALSLTTDICTDTLNNKSYLGFTAHYILNNEIKSVTIGVKELDQKHTSENIQKWIIEILENWAIATLLDPRFKKIHFNDRLACSKAIDKISRLFREMTTTENNSSLQEKSDKVSDLKEESFWDLHRELVQKNNSIREYRNEEELLACSKAIDKISRFLREMTTTENNSSLQEKSDKVSDLKEESFWDLHHELVQKNNSIRESRNEEELYDELKYYLNQPTIGMNESSIEYWNRNSTSLSTLAKRYMVIMVTSVPSERLFSKAGRIMTQDRSSLSPKHLQHLLFLASLRKKDWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAI2</accession>
    <name>A0A232FAI2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_002487</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000601">
        <property type="protein sequence ID" value="OXU27448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAI2"/>
    <dbReference type="STRING" id="543379.A0A232FAI2"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="12">
        <location>
            <begin position="99"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="13">
        <location>
            <begin position="227"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU27448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="281" mass="32540" checksum="090B3A5C3625968C" modified="2017-10-25" version="1">MAVRLRQSLAVSCFIIGRGRYHQLALHKIRIIPSWKMANDAQQSKNHTSHAYNVDIGGMRIKYKDKSDCFTEDHLVSKEPFDQFKHWFEIACKTPGVGEANAVFLGTATKDGIPSVRPVLLKSFGTDGFKFYTNYGSRKAKELEENPNAAMTFFWEPLRRTVRIEGTVEKTSAEDSDNYFYSRPYHSQMGSVTSRQSTVIPSRDYLIEKEKELQKQYPDKVPRPDWWGGYILIPKSVEFWQGQSDRLHDRIKFRRLQPGEKPDNVLVHEGEDGWVYERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBM8</accession>
    <name>A0A232FBM8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000524">
        <property type="protein sequence ID" value="OXU27868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBM8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="382" mass="43151" checksum="7E259B8090D0FFB5" modified="2017-10-25" version="1">MWSDSEGSLDTRQVPTHPSVPTVHRTEPSEIVEAKQQIKFCSENLPAATKSRSTEQEEAEDKDNIIARLMQQLQEERQKNRVTSVTPPAATTSNNKCNDTTISPVLSNVNLRSRKAKRKNFAAAYVATPTGSRVMISGELRSGKENPPTSPETESPSLISAKSLSRKSTMMKTPTKRKRNNSVDVTSLIDENSDALTVTPSFILRKKLSPRRVNLVAKQIAGPSGANNQSNPDKKRKNKYERKIKECLYDSDDYNSSNLPKRKSFTKWDHEEISPDGFLTKIAMFHIHYGVSVPYKSWKRAITSESSYGFLRELVVPHIWSREEFVKRAIQVTRTHDSSNRLELSPTKRESLKRGYVQYLIERRSIPSKVSTEAEKESGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBW4</accession>
    <name>A0A232FBW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000534">
        <property type="protein sequence ID" value="OXU27827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBW4"/>
    <dbReference type="OrthoDB" id="10492514at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="149" mass="16694" checksum="98A06BEE31F8F5CA" modified="2017-10-25" version="1">MLETSVPENIIKMLYIIPPHIRPISLITIYLIVTNFDSSLDGRSCKDEIYRMGLGAGYCEGNLNFATASEDDEVYTKKKVSRLINIGIRLALNATTQLVTRSGPVWRSFLFSLSSAEDSRRNSDNRANEVYDGEVVETVRLGNRVCGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCK6</accession>
    <name>A0A232FCK6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000464">
        <property type="protein sequence ID" value="OXU28189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCK6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8561" checksum="71E314E5F4A2182C" modified="2017-10-25" version="1" fragment="single">MRTLIYESMYKHDVLTDSVLFKCNYCVKSVINVLKVINDEFCTDISTTSRLVKLFRNRQRRVVLYGFGVEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDG3</accession>
    <name>A0A232FDG3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_009279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000376">
        <property type="protein sequence ID" value="OXU28801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDG3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24445" checksum="C9F25D44E05B39E9" modified="2017-10-25" version="1">MTIYGCLLTTPTINVYYEINFHIQNRNSKAALAMLKEHPLQSRFYDGDGLTHLHIAVSKGLTDVAIYLMKQGCNVNFADCEGNTALTLAMQNLPFERDTECIYYLLYYGGNLAQKNKEGLNALGIFAERNLFRKKNIHHALLLAIKSCKLSDIKIAELLHDAKWPISAVLDIQKPNVISIMEEMDDNARRRILPSQTMSSFNTPRSQYRRPQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDK9</accession>
    <name>A0A232FDK9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000414">
        <property type="protein sequence ID" value="OXU28568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDK9"/>
    <dbReference type="STRING" id="543379.A0A232FDK9"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="277"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="648" mass="71213" checksum="9EC934FD36B04FA0" modified="2017-10-25" version="1">MSRHRDVRSMNYTDEYDGYDDVYGHSVEDDYCVSPSAEQFMFDRNKSANMSSFFTEPDILEANEEEEEVAVPSSYKLPELTDLEAAKLMSCVEAVKNVIGETLPESELNKKIIEFNYNTEAVLNSILNDETRSNKDKQPAEKDLVEAQSGKRRGGAAAAKVVPQLMMPPVKVVPSASKTIVKGFDVSAENVDLLRSPRTQSPSSERSSPDPSSRDTSLRKESKKQQASGGSVIGKSSSSRSESPMASDSESQVEVRVKPEEKRDALVVYKNKREGCKEQLHLIVVGHVDAGKSTLLGRMLCDLGQVSAKLIHKYQQESKKIGKQSFAYAWVLDETGEERERGITMDVGHSKFETNTKSVTLLDAPGHRDFIPNMIMVDWSKERYNEIVNKLGAFLKQAGFRDSVTYVPCSGLSGENIVSKPESEGLSSWYTGPTLIQVIDNFKCPERPVDKPFRFSVNDVFKNIGSGFSVFGHMETGMVSVGDKVLILPRNEPAVVKGIQIDEANTSHAFAGDQASLILSGIDQQNLAIGDIVCSPLNPVPVSSCFQAHVVIFAVKTPLTNGMPVVLHQQSLVEPAVISKLVAQLNRSTGEVIKKKPRCLLKNSSAIVEITTQRPICVELHKEVKQLGRVMLRIDGATVAAGLVTKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDT2</accession>
    <name>A0A232FDT2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nucleoporin Nup37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Nup107-160 subcomplex subunit Nup37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_009804</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000356">
        <property type="protein sequence ID" value="OXU28946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDT2"/>
    <dbReference type="STRING" id="543379.A0A232FDT2"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000168">
        <property type="entry name" value="Nucleoporin Nup37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 22" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU28946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="322" mass="36348" checksum="DECE75E28D0F9C58" modified="2017-10-25" version="1">MEEAMTTQPTFKLNFAKQIQCVEWSPYEWSQHLICIALGEEIIVATIKFQEDDDIVEDIIYTALRTFHHETRVHAIAWSPETSLSVVPKIVSFCVAGADFKIRLYNSDLSESNIFEVLEGHKDYANDICYDPDGELLASVSDDHTCKLWAIKEDQKCILTFPLTAPGMTVRWHTEETGKLLVAEKNGIIRMYNVRSQQAIMSVDAGTIPLLTADWSPNPLKVACISSGELILWDMSRPSRPLEKRTLHVEGGLIMKFSPSNENLIASIGRPDNILKVVNLKSKPPILCGRVRLLGGLTWHQRIQIVCAGSDRQLLFWKVNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDY6</accession>
    <name>A0A232FDY6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000398">
        <property type="protein sequence ID" value="OXU28669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDY6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="31" mass="3537" checksum="2A98193F2D2564E8" modified="2017-10-25" version="1">MGYNGFAHSSALFSRGSVRIDNQAPYSHFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEP7</accession>
    <name>A0A232FEP7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein slit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004994</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000318">
        <property type="protein sequence ID" value="OXU29264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FEP7"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010631">
        <property type="term" value="P:epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010160">
        <property type="term" value="P:formation of animal organ boundary"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008347">
        <property type="term" value="P:glial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007498">
        <property type="term" value="P:mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022407">
        <property type="term" value="P:regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048608">
        <property type="term" value="P:reproductive structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000729">
        <property type="entry name" value="Blast:Protein slit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000142">
        <property type="entry name" value="Crumbs cell polarity complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000080">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000134">
        <property type="entry name" value="Slit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000063">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000002">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000004">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000032">
        <property type="entry name" value="Slit homolog 2 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012489160" description="Protein slit" evidence="11">
        <location>
            <begin position="46"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="939"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="976"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1053"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1093"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1140"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="13">
        <location>
            <begin position="1182"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1409"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="12">
        <location>
            <begin position="1452"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1418"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1437"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU29264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1523" mass="168997" checksum="53C368367E84C907" modified="2017-10-25" version="1" fragment="single">TCSAVRREPFAEKRQKKNKKMATGASWLLLLAAAVLLASEAGGHGSPPMDGGPDSLSGTIGNHNGVRCPWACNCGGQELDCAQRGLTQVPGNLAALTLAEKLDLQGNNISVVFKTDFEDMATLRLLQLSNNQIHTIERGAFQDLVSVERLRLNNNHIRFLPDLLFSNMMNLKRLDLSHNQITMIGPKTLRGIVSLKHLLLDDNELSCIDEAAIRELKELEILTLNNNKLTTLGKDIFTGLVHLRNLKLSDNSFMCDCHLMWLSRTLKTFSRLGQNTRCSSPAHLKGKNLVDLQEQDFKCSGLVEKPSSECSTEPQCPHPCRCADGIVDCRENSLTKVPTYLPEDTVELRLEQNGITEIPAKAFFPYRKLRRIDLSNNKIRKVAADAFHGLKFLESLVLYGNKISELPSGIFQGLTNLQLLLLNANEISCIRTDLFHDLTGLTLLSLYDNNIKSLSNGTFANLRNIKTLHLARNPFICDCNLRWLSEYLHKNPIETSGARCESPKRTIKRRIDNMRDEKFKCKGDEEVLTKRAGECILPGPCPSSCTCNGATIDCSNGKLTSIPKDLPVYTSILLLANNAIEKIKAEGIFEKLPELQHLDLRANKISRIEASAFEGAHKLTDLVLSDNKLREVHTKMFSGLTSLKNLNLHGNAITCMMPGSFDNLPHLHSINIQGNPLSCNCHLAWFAEWLKKRDSTSVSGHCHDPPRLKAAAISDIPRHEFKCNSELIVTASAASATTTARRXXXXXXXXAGSVVRCSRSRLTEIPRGIPPETTELYLDVNDIKTIQPERLAHLSILTRLDLSNNQIGMLSNDTFRNLTKLAHLIISYNKLQCVQRGALAGLKSLRILSLHGNDISVIPEGAFEDLKSVTHVALGSNPLYCDCNMRWLADWVKRDFMEPGIARCAEPASMKDKLLLTTPASSFQCKTKQQPAEVLAKCNVCYTTPCQNGGLCEALPHKQFRCKCAPGYHGDRCQHKIDACYGNPCRNAGTCKVLEEGRFSCNCAPGYEGLRCENNVDDCANHKCVNNATCVDLVESYRCDCLPGFTGEHCEAKIPFCTKEHNPCKNGGRCVDHQSHYSCECPSGFAGANCTDNLDDCDNNLCQNGATCIDGINNYECKCAPDYTGRYCEVAPSTALLYPQTSPCAHHDCQHGACFLPSPGSGADYLCQCHPGYTGKRCEYMTSLSFTDNNSLVELEPLRTRPEANVTIIFTTSQENGVLLYDGQSGEHLAVELFNGRVRVSYDVGNYPTSTMYSYEQVSDGKPHMAELIAIKKNFTMRIDRGAARSIINEGPKEYLKLTKPMYIGGVATETANVAFTEFHLRNITSFRGCISEMWINHKLVDFSNAAKMNGVTPGCGTDDEEADEANKATDVTDNMQVDNADQVVVPQQQQQQHVHEHSDFAVLSSSSNIDPCMRHECKKGSTCEPAPFGTGYTCKCQIGWQGRYCEKAPTCRKEHIREFYTANGCRSRRPVKLAKCWGSCGNSCCLPRKTKRRKIRLICNDGTRYTKDVDLVRKCTCTRKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEQ8</accession>
    <name>A0A232FEQ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMEK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000320">
        <property type="protein sequence ID" value="OXU29246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEQ8"/>
    <dbReference type="STRING" id="543379.A0A232FEQ8"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000051">
        <property type="entry name" value="Serine/threonine-protein phosphatase 4 regulatory subunit 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="819"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="843" mass="95579" checksum="AE721BBC6F519047" modified="2017-10-25" version="1">MTDTRRRVKLYALNADRQWDDRGTGHVSSSYIDRLKGTSLLVRAESDGTILLESKIQPDTAYQKQQDTLIVWSESDNYDLALSFQEKAGCDEIWEKICQVQGKDPSVEITQDIVEESEDERFDDMSDSAPPIELPACELGRLEDINELIGNCLSSPMRKEKLAMALESEGYIRKLLNLFHTCEDLGNMEGLHHLYDIFKNIFLLNKNALFEVMFSDDTIFDVVGCLEYEPTLPQPKKHRQYLQQLAKFKQAIPITNAELLAKIHQTYRVQYIQDVVLPTPSVFEDNMLSTLSSFIFFNKVEIVTLIQDDEKFLTELFRQLTDENTPDSKRRDLVLFLKEFCNFSQNLQPQGKEAFYKTLTALGILPALEITLSINDAQTKTASIDILNYIVEYSPSVIRDYTLQQINNTEQDQMLVNVIVTQLINDIDHELGGAVQLAGILRLLLDPENMMASVNKSEKADFLNYFYKNSIGTLIAPLLANTIGDRPVREDYRTIQLLGLILELLSFCVEHHTYHIKNCILNKDLLRKILVLMKSTHTFLVLCALRFMRKIIALKDEFYNRYIIKGNLFAPVFDAFTRNNGRYNLLDSAILEMFEFIKLEDIKSLCSHVVENFSKELEAIDYVQTFKALKLRYEQHQDKLKDRDRGALDSVPSILRNSRYRRDQRQLDEEEEMWFNEEEDFDEGEAVVPAATADLVPPTSAKKQPSSPNSVAGSGIVDNPNKDGSSPPHQQQHSPPQQQQQTILNNNTSNSNVSAVVAAAVTTTTVTTQQQIDSGVSSTISGTNDLPVVSVTAEAMNSSATISAVDKTGSNIFKKGLVDYEGDSDEEDEESELSPTPKRQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHI9</accession>
    <name>A0A232FHI9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_017029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000206">
        <property type="protein sequence ID" value="OXU30033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHI9"/>
    <dbReference type="STRING" id="543379.A0A232FHI9"/>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="571"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="656" mass="76709" checksum="F6FBB149DFD2ED5E" modified="2017-10-25" version="1">MASFETLRKDYSKYVQQCLKSSDIATFQKKTIEQCANDKDRKPAIDQALRDTLVIILSNNATNYTRTLESYIKFCIELCRKDLATTSMPVMLLSDMFDALTLNLCEDLFTYVENNVSTWKEDLFFGACKNNLLRMCNDLLRRLSRSQQTVFCGRILLFLAKFFPFSERSGLNIVSEFNLENITEFGSEKSEEEVIQQMEVDGEKSETKICIDYNLYRKFWALQDFFRNPNQCYNKMHWKCFSTHATNVLSTFASFKLEDQKDCIIDHLKIESLLDGRYKDNHYFAKYLTNEKLLELQLSDSNFRRFVLLQFLILFQYLNSTVKFKSETHELKPDQVEWVNTTTEQVYLLLTETPPDGTAFAEAVKHILKREEYWNSWKNEGCPAFKRPAPEPMTEADEARKPKRLRRKIGDLIRDAQAVGKYYMGNQELTKLWNLCPNNLEACKSKDRDFLPSLETYFEEAIEQLDPTAAIEDEYKKVNDGNFGWRALRLLARRSPHFFVHGNYPINKLQEYLEIMIKKIAKDRPQVQTDIKQEAGETPPSEQIEQDFNEETLKQETEAIESKPKVINRISRELVEKLAEVMKDDWETLAAKLGYTNDEIVFFGKKQTPYEQCQEMLVIWTEEDPEASIEHLKSILQELNCTEALEIVNSNTVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHK1</accession>
    <name>A0A232FHK1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_013410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000235">
        <property type="protein sequence ID" value="OXU29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHK1"/>
    <dbReference type="OrthoDB" id="6047381at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF1">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="14">
        <location>
            <begin position="427"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU29817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="672" mass="74369" checksum="BBEAA8F085216D5D" modified="2017-10-25" version="1">MSRRTAPLVSLNSCERIRPERPRNAIQRLVWVPGSQFHVGFAGGVGEDEGSNPRMALRRLLRLYEGRQYREAAGFLMRLPQYTLRAALPDIPIDLLIDTLPHSLVLLEALYARLLELGVRDAQVLRLEQLLWKVVGLLSNTQDHFHLRAWARLLSALNRAAPSARTALISRRRALERAVEGLGKHGLVPANKPCGGSSSSSGESVSPSSCSTSNLVSLPVALKEQLEMRADAYKLALHKIESLGKHAGLHKGDQGVQAASHQRLLGLKYSEVQQRLIDNQSLLNTLERTRDEELDRLLVELKARVEQDKEALRQWTALRKCEAGAHQKESNAVSESKNTQSLAARLLLFSRGCAMALQLMNGGDCTLDSNNSSIVGEYDEEEEEEEESSSSAGYHTDESCSPTPEPNRGTTQGETLQGLACPDVTVDRLRERYAALYSQANLHTLDALDSLEPLKDAPELKAKILYSIVVLSWRLAGILQASRRIEALKVLNGGNSQSQASAPPDLEDCIRRQLATVGAQSGAREVAHQVTSQLERTLHDFPCLRNSAEVRKYALSCSRLAWACLARTTPLVLDVAQGVEFRREVHARHHSSPNPNGSRIKAVLWPGLREGCQGPLSPPPLHLRSINLYSQDVCHPNEFRRMMDPSRADHKINHASQISPAQRNQSSTKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIG3</accession>
    <name>A0A232FIG3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dual-specificity kinase</fullName>
            <ecNumber evidence="4">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_002869</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000151">
        <property type="protein sequence ID" value="OXU30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIG3"/>
    <dbReference type="STRING" id="543379.A0A232FIG3"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000202">
        <property type="entry name" value="Dual specificity testis-specific protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012692057" description="dual-specificity kinase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="10"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="605" mass="66621" checksum="EA7CA8389F1118F3" modified="2017-10-25" version="1">MTPHIHQTPVKCIARLNSFFLSLFFQVTHKVTGHVMVLKMNQLPSNRPNMLKEVQLMNKLNHPNILRFMGVCVHEGQLHALTEYINGGSLEQLIMARHTPLPHLIRMKLARDTACGMAYLHSKGFFHRDLTSKNVLVKRDEATNELTAVVGDFGLAAKIPDPSTGYRLSTVGSPYWMSPECLKGQWYDHRSDVFSFGIVVCELIGRVPADPDVLPRSDNFGLDYLAVAEICAAADPPPAFLQLAFQCCTYEPRSRPTFPDIVQTLDNLIATHADDSKASMDKRQSVDQELMSSMHEISRQSRSLGRKSARLRSHSADARACAANSTPPCDKARCHSARRIAELASRRDPHYRPMTANPFHALGGVKKILGDLFSSCLELPSLEDVRSGGESSGTTGKFKAATNDCIAKILERKKPSSEPSSPTARKKWEKKVATKVGAASLFAHPLFRDGWEPRRRGSCESGFWSCVGEDLSPEPPNRRHASTLSSSAASSLFLLDDHRTSSIYTDSSEDIASLGGGDSACWEDRLDRLGPSSKTIAKIVDYFERKQAGAGKHGEHGYDVAAPSRIALLRARLEGSMPLCSISAAQRLVVCDGAVRSKLPLFDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIV3</accession>
    <name>A0A232FIV3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000132">
        <property type="protein sequence ID" value="OXU30676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIV3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8680" checksum="A9F13BC4FD31D993" modified="2017-10-25" version="1">MFRCSGLRDPRRLASAKKRAHQYQKTLTQATIKPHEALEAHRSRSRSRILSIRKLHKKPRYRSPERVLPPRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJE5</accession>
    <name>A0A232FJE5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_012655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000114">
        <property type="protein sequence ID" value="OXU30851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJE5"/>
    <dbReference type="STRING" id="543379.A0A232FJE5"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF264">
        <property type="entry name" value="MIP05773P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="10">
        <location>
            <begin position="298"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="909"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU30851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="964" mass="106810" checksum="40CC188862F7A9F5" modified="2017-10-25" version="1">MNRWRGKVAVVTGASSGIGAYVSELLVKADMKVVGLARRVEVLQQMATRMDKHHPGSFYPVKCDLRKEEDILEAFKYTEEKVGPVNVLVNNAGFIVSDRIIDSSTENFRKILDINVLAVAICIREATKLMRKHKVHGHIVNVNSVAGHEAARIQVPVNLYCASKYAVTGMTESVRNELTSLNSGIKITSLSPGPVKTDMIRAAGIPDELIDKVPILEAKDVAEAVIFALSTPSHVQINELTITPLDETVQDARDSKMKFPSSCILPIIAIISVESVPRKLRSSGSINSIPASSSDSPPNIVMIIADDMGWNDVSFHGSDQIPTPNIDALAYNGVILNSHYVSALCTPSRSALLTGKYPIHTGMQHLVILEAEPRGLPLHEKILPQYLKEAGYATHAIGKWHQGFHRREYTPTYRGFDSHFGYWQGLQDYYTHEVGSSNPKEGFLGFDMRRNMSVARDTYGKYSTDLFTDEAVRLIEEHRPESGPMFVYLAHLAPHSGNDHEPLQAPDEEVAKFSYIEDPERRIYAAMMSKLDQSVGEVVSALRRKNMLQNSIVVFMADNGAATQGIHYNRGSNYPLRGIKASAWEGAVRGAAAIWSPLIQRPKRIYNELMSIADWLPTLLSASGLRDVVRVSANIDGVDQWPAISGLAPSPPRNEILVNIDPIFNYSALRRGEFKYVLGTVGNGEEWYGETGRPENHGLEGTSPTYDPETVLMSKAGTAIAGLLTSKQVSEIRAVRKDTYGRVKDDEMATSKLLTVDELLKLRSSASLRCTVPESERVACHPLQSPCLFNIKEDPCEQRNLAASRAMILATLEEALLKYRVTALPPSNVPNDPKANPAFWNHTWVNWQDDDPYEFLTDMVGKNKLENINDRMPGSVIAVIAVLLGLAVVAIFALIGLRCNKKYHALKKKQQQSDYRNSRHFQEVQQPSETQAVLEPEESQPNGKIVESFTANETRDAPSIKNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK10</accession>
    <name>A0A232FK10_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_010494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000117">
        <property type="protein sequence ID" value="OXU30798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK10"/>
    <dbReference type="STRING" id="543379.A0A232FK10"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF39">
        <property type="entry name" value="IONOTROPIC RECEPTOR 56A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="64720" checksum="F86D84258598F365" modified="2017-10-25" version="1">MAIINHCFSIQSRNIILYEKRTLTLFPMLNQTSSLLMSIQNDKRSVNSTIVNNIYNYDDVIVNNKNSPVKSFVIIVSTRSMLSLALKKLKDSIWWNHDVTLLLVNTELSLDGCSDAYEFLHLVWIFNILSVLFVCSSNQYGVQLYTFDPFSNVAPSPWDSVKNIDSSLCQNLYFDKTRDLHGHVVNLGVFVQSSTLPFDDTKVGLDRFGGVNGEIAKEIWTKLNVNARVQFYKTMGTFDAKGNPVGFYEDLRLHRIDYVMNMIFFRYFWKLQTYPHESSAICIISYKDRSSIGSLRELLSTITSTFWIIVIIVSVILNIALKFLLNENTSSSCLELLRMIISVSSLKEPQQYSRRFFFAYIIALTMMSNFYFQSSLSSFSIAPSSKPVIDSEESLLKSDLIIYGRASMRSFLNLSDPKHKERYVNEEFSKCAKRLLQGQRVACISGCISSRYNIYEGGTVHISEEKRHTFMSFAVRDNWPLYFRVNQILRRMSEGGLIVLFRRREMRLFKRPPGFRKSIKSITMRDANFAFYVWNVGVVVSSCVFVCEIFLVKIKTKISVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKC6</accession>
    <name>A0A232FKC6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000076">
        <property type="protein sequence ID" value="OXU31206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKC6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8653" checksum="4733D21EF525486E" modified="2017-10-25" version="1">MRAHTVGVYPADEIPMTWVKLCGFVFNTQSHKRPSKKYDPTDFHWIPSTAPVIHWSHWSRHFVYKSKVEVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKG8</accession>
    <name>A0A232FKG8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000116">
        <property type="protein sequence ID" value="OXU30817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKG8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="47" mass="5455" checksum="098EAE01D528D7D9" modified="2017-10-25" version="1">MGSTTEDFGITTTPLYYLASHCTFFTRSTIRFESNWSLFENQLARVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMA3</accession>
    <name>A0A232FMA3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000036">
        <property type="protein sequence ID" value="OXU31713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FMA3"/>
    <dbReference type="OrthoDB" id="7551855at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="113"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU31713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="393" mass="43124" checksum="5AFF26109E1C9BBA" modified="2017-10-25" version="1">MEYVGRMIEEGECGSSITICSDSKAALLALSSVSIVSKKVWKCRQALTTLAARNGVKLLWVPGHSGVAGNEKADRLAGRGSCGMRAKKCKIAVPACEVSKATRKWLRRKLKEEXTEGLVHADGSKTANGVGAGAWEKGSAQEIVCSLKQHATVFQAEIRAIMEYVGRMIEEGECGSSITICSDSKAALLALSNVSTVSKEVWNCRQALTTLAARNGVKLLWVPGHSGVAGNEKADRLAGSGSCGMRAKECKIAVPACEVSKATREWLRRKLREKWKSNPGLRQAKLMMDEDPPEEWIAQIGNLSRGRLRVVVGWLTGHWQVIYHLFRIGIREEGGCRWCGEMQESTLHLLCECPAFVGMRCRMLGTPSIKVEGLRLLNLQLVYNITKWFGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMM8</accession>
    <name>A0A232FMM8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000026">
        <property type="protein sequence ID" value="OXU31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMM8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17809" checksum="4DC8B69E5214A407" modified="2017-10-25" version="1">MRLFLPILFLKKRYVTANVNNNAAKQKNAVNINERKYSFVTRGFLAILPEVPGAQGWQYQHRLLEYLMSRVDSINIISWDYLKYRTISMLSGPRNPMSLILFTVGTRYLGERCRHDILILRPQKPPSNKTGLISINIYGVLIYCLFCCTLHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMT3</accession>
    <name>A0A232FMT3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000026">
        <property type="protein sequence ID" value="OXU31829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMT3"/>
    <dbReference type="OrthoDB" id="7553161at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8466" checksum="106B668121606DF3" modified="2017-10-25" version="1">MRRPLVRHLSEGGGGEGTRRQSVKPGEDVVGNSWTCHDYRRHQSSCDLLKVPSVNPRGRLSPEPRITVTNIFNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNU0</accession>
    <name>A0A232FNU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000003">
        <property type="protein sequence ID" value="OXU32233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNU0"/>
    <dbReference type="STRING" id="543379.A0A232FNU0"/>
    <dbReference type="OrthoDB" id="5831756at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7500" checksum="5057CC3728C51BD9" modified="2017-10-25" version="1">MLEHSEAFRTNIIQIKKGIIHNNLSYIDESSQQFNTYVTLKLQNVKSTTVTVKGANPCWEQDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDZ0</accession>
    <name>A0A232EDZ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005802">
        <property type="protein sequence ID" value="OXU16553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDZ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="5880" checksum="3458E9DEE8652BAC" modified="2017-10-25" version="1">MCAKFAKICLEGQPVFSEQRLLCTQEPHFFLNPKGMRLPWLDLPMICLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEB9</accession>
    <name>A0A232EEB9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005397">
        <property type="protein sequence ID" value="OXU16695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEB9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12930" checksum="5CEC22C8C4C80B22" modified="2017-10-25" version="1">MLKSNQTQNISRAVMHIPEYNGININLKEFIQNVIKRQGKRNVERKHLRDFSSSEEPSQRLLCFLKIVWSLLSPVLLQVGKGNFHLRSSNQVFLEDVRMDFWRSTALFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EED4</accession>
    <name>A0A232EED4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005390">
        <property type="protein sequence ID" value="OXU16707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EED4"/>
    <dbReference type="OrthoDB" id="10060618at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="230" mass="25975" checksum="5C5F21CA01454E7B" modified="2017-10-25" version="1">MAKRLSTALREIVKSAKAKRITLGGKSAGALTNKVIGTLSGYYRNAIVGDKNNVRDMQKQIIATLYHSSSTDKKHNHSLCPQGKQSWCFYKRAVVVENILPIYERLSNEELLARCTQGFTQNANEAIHSVLWRKCPKNNFSSKTRVEIAAAHALSEYNLGRQRSAEILASITSSKMTSHAEKITTQKDKKKETRLTRNMNQSLKLLEFQKICQITGFDIIEIRLMLSEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEZ4</accession>
    <name>A0A232EEZ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005163">
        <property type="protein sequence ID" value="OXU16930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEZ4"/>
    <dbReference type="STRING" id="543379.A0A232EEZ4"/>
    <dbReference type="OrthoDB" id="294052at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="4">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="244"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="915"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="928"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="962"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU16930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1027" mass="117150" checksum="D95EBC54D2035526" modified="2017-10-25" version="1">MFRSRSWFGGGLWKPKNPHSLEHLKYLYNVLSKNQTVSENNRGLLVETLRSIAEILIWGDQNDSSVFDFFLEKNMLSFFLRIMKQKCGSYVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIIVHKFDFSDEEVMAYYISFLKTLSLKLNAHTIHFFYNEHTNDFPLYTEAIKFFNHSEGMVRIAVRTLTLNVYRVEDASMLTFIRDRTAAPYFSNLVWFIGNHIIELDTCVRNDADHQSQNRLSDLVAEHLDHLHYINDILCLNIEDLNKVLSEHLLHKLLVPLYVYSLTRRKDLLCQNHEERKYVSTVVALFLLSQVFLIISHGPLVQTLAAVILKSNIHIIKNGASKVLEEYEDTVSSETVAFLPPKESLEKSLENLNDLQNDSPKLQNVEEESEEEKEMGEHADKDEGDNELVNKVTLEKQKENWYSTEKVDPSEPSVSSETETSLVNSEVEKKDVANETIEDIKHLSVTDEEKEQRLALESPLEATAITADQESLSDKPFLETILNSLYCTENDYAALFALCLLYALANNQGVHPETLGLVLAPLKHPNKSRYNETLIDRIIHIITLSCQTNAKVRLVTLELAIKLLIQLVVSDNESLLQGCHLAAVEAAKEQSTALLRNFYKSEDIFLDMFEDEYSEIQKKPLKVEWLMMDSNILLPPTGTPMTGIEFSKRLPCGEVERARRAIRVFFLIRELSLTLSNEVETHLPLTDPSNCVQVNNVLDFNNSELIIACTVVWKDGQKIRRFLVIDLIQLILVEPDTRKLGWGVAKFVGFLQDIEVAGDKDDSRCLHLTIHKPLSSGASNRVPLLSAKFIFDDHIRCMAAKQRLTKGRIRARQNKMSRIARLLDITTTAPHCPTSTNYALRYLRIERTASHGQKIPKEQQQEQRMFIVNKVPGFGVQMRRESLNKSAGSSSFSGSSLKRVDNSPARTRDNSPKMPRPRSEEIPLEDMRLRKTSLTSNMSNSSGASDHHKDTTSVAQISTPNSGAEISTRKRGSEETSFTERHTHESRPRRKGQVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFM9</accession>
    <name>A0A232EFM9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004956">
        <property type="protein sequence ID" value="OXU17179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFM9"/>
    <dbReference type="STRING" id="543379.A0A232EFM9"/>
    <dbReference type="OrthoDB" id="2163395at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038792">
        <property type="entry name" value="CFAP97D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33768">
        <property type="entry name" value="MIP11318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33768:SF3">
        <property type="entry name" value="MIP11318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="12532" checksum="CE58BC973FFD5475" modified="2017-10-25" version="1">MSSTRDSKSASSRNCKSADYSWDRRSFEQHRRRVREATPTVNVKTPDRRPHVRYDAKRLQLERERQTQIARDNFILFKRLTEIMSGKLTNKYPLTQSKSKCIKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFT2</accession>
    <name>A0A232EFT2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004932">
        <property type="protein sequence ID" value="OXU17220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFT2"/>
    <dbReference type="OrthoDB" id="7697815at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10030" checksum="C6B2039237F8BB85" modified="2017-10-25" version="1">MISMKNICDKAATNSGQREFIEGKSVYQAKFIIKCGKNAVFKNSGTISFEAVCLQTTAIKDKHPHEINSGISTSGDIVHCSCTCKAGLGKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHK0</accession>
    <name>A0A232EHK0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004489">
        <property type="protein sequence ID" value="OXU17825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHK0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="37" mass="4461" checksum="07B67ACA443BF3C5" modified="2017-10-25" version="1">MELIDNNEEIFYKLKRLVRLTKNHCLIKGSVNRLYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHR7</accession>
    <name>A0A232EHR7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004448">
        <property type="protein sequence ID" value="OXU17885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHR7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9900" checksum="C71530B185DBC238" modified="2017-10-25" version="1">MFSLLRVHLTGHNRNMDKHNMEKKKKKEGSDREEVKYKPASGFQKYLPQYSSNTGSFLKKEGYRSYCPDKEANKDSKYEGYNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHV9</accession>
    <name>A0A232EHV9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_002773</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004418">
        <property type="protein sequence ID" value="OXU17933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHV9"/>
    <dbReference type="STRING" id="543379.A0A232EHV9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001499">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF6">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="454"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="542"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="641"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="691"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU17933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="782" mass="83540" checksum="E96E35AF176131AC" modified="2017-10-25" version="1">MGGELRPRGAVGGCSTPGSRVDPWWNPSSFCPSVSSPGPPRIDEGPPLDNDDYQFCSLQAGNNNNNNNHSNNNRLSSIANHYHQQQQPHHQCHNSDNGCYNNGNNNNNNNNNTSTAASLGYVDSTRSNVVVGSDNSDPYNLITSSLQQQQQQSETAGNASRVDSSQQQRQLPQLLSSSSPASSSTSATIPASPDSLNGILSSFGSGNGGRIKQEDSEDRATSSTNFSPSLLSSLLSTSRISAPSGKSYGRRDNGSSDACASNSSAEANSQENGDAGNVLLGPVKLEYPDASSDPRDEHVKVEYSLAGSPTELLLKQRATSTDITAIDMKFETQTGPPTTPSHLSSSGVEPPHSSQGNQGIVVGGSPGEVVGVENMLLSPWGATGTEFLEAHESKQTAAGLDDAWDTLLLGSSVGITANQSLAELKPLPPFTNYTGHLSINGIPGHHYHTIASSAQRPVMQSTSPSPSSNQEYYESSVVSSSTPCPQNNQKQQQQQQHHHHHHQQQQQQQQQQQQQQQLPQSTQQTVDYNIEDLAEIIGSAMADTTVPGSGNSGHGNNAGNNGASSDHDPEVSPRDWIDIADWIDTACSPKTQETSSSSPYSQMYATAATTTPSNPGQQQHGSTLQSLLTHGYSPMLQQRLQASCGETPSSTSPYPPVSPPGRVSTSCSPDHHLHSSSFVTPQHTRKRSRPSGGSHNLSKKSPGTTTATLPYGTESGLIGGKEKPVHRCSICNRGFLNKSNIKVHLRTHTGEKPFRCEVCGKAFRQKAHLIKHQQIHKRIGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EID3</accession>
    <name>A0A232EID3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004302">
        <property type="protein sequence ID" value="OXU18081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EID3"/>
    <dbReference type="STRING" id="543379.A0A232EID3"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002048">
        <property type="entry name" value="Septin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="10">
        <location>
            <begin position="36"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="340"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU18081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="420" mass="49143" checksum="AC97EAC0224596AB" modified="2017-10-25" version="1">MKNSKPCEPFTRHSTLQGHIGFDSLPYQLVNKSATQGFVFNILCIGETGIGKSTLMDSLFNTTFESHQSPHTLEKVKLKANTYELRESNVRLKLTIVNTVGYGDQVNKSNSLKDILDYIEAQFEDYLQEELKIKRSMPSYQDTRIHACLYFICPTGHGLKAIDLVCMQKLDKKVNIIPIIAKADTISSLELKHFKNKVIGELGNFGVDIYKFPTDDESVADVNMKMNAQIPFAVVGSTDFIRVGNKMMRSREYPWGVVEVENESHSDFVKLREMLIRTNMEDMRDKTHNYHYELYRRKRLQELGFEDTENEEGRFSYQRVCEMKKAAFEQETQQREDDMRKSFVIRVKDTEAELKEAQKELYDKFEQLKQDCAEEKKRLDEERQQLEKEIKEFNRLKVQATCMQYQSTYTLTLRKNKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIH7</accession>
    <name>A0A232EIH7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DAZ-associated protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Deleted in azoospermia-associated protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proline-rich transcript in brain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1. In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters. This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death. Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes. Plays a role in stress granule formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004280">
        <property type="protein sequence ID" value="OXU18111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIH7"/>
    <dbReference type="OrthoDB" id="6514304at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022730">
        <property type="entry name" value="DAZ_assoc-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31638:SF3">
        <property type="entry name" value="DAZ-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11029">
        <property type="entry name" value="DAZAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU18111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="200" mass="20904" checksum="584BB0CB7B0D2E6B" modified="2017-10-25" version="1">MASANAHSAADSGRRSILDAYYYNNNSNRAYPVAPHPPTGFVPAQAQPAAYGVPGASPYGVFPNQPQLYATQGPPPPTYDQTLTHPMMYQPMYGQGYPGGYLAGYPTAYGPLQYYPPLAAAAAYYPTAMQPAPVRPTIMVSNGFDGARFDGISQPVLPPPPPGVAANAAQLAAMAGHSVALSQKKGSFLGGGTEGGYTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIR3</accession>
    <name>A0A232EIR3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004176">
        <property type="protein sequence ID" value="OXU18235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIR3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="33" mass="3496" checksum="288723C1B2EA9300" modified="2017-10-25" version="1" fragment="single">MLPSVGTVCVCTVRPGGGDPRPSVRKKARGVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ17</accession>
    <name>A0A232EJ17_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004145">
        <property type="protein sequence ID" value="OXU18301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ17"/>
    <dbReference type="STRING" id="543379.A0A232EJ17"/>
    <dbReference type="OrthoDB" id="7612378at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="20768" checksum="CD06A75F333CFAA2" modified="2017-10-25" version="1">MDIILDNQGFKGQNGEYIIKELAYIDPNEPAAMPQLVTFQPPCSWYNLSNDVKCANLWLKYSFHGLKWSNGDVPYEKVAEVCASLLDLSPTRNVIVWVKGAQKKEWMQPYFPHIYNIEDLGCPSLKTPGYRSPVVCTHHLPGWKESCAVQNLCAINKWLRTRRQDFTFPLHVYEDYYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ55</accession>
    <name>A0A232EJ55_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_016109</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004081">
        <property type="protein sequence ID" value="OXU18399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ55"/>
    <dbReference type="OrthoDB" id="8175157at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF9">
        <property type="entry name" value="ODORANT RECEPTOR CORECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0085">Behavior</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU18399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="476" mass="53396" checksum="25A175C2F9350C05" modified="2017-10-25" version="1">MMKMKQQGLVADLLPNIRVMQGVGHFMFNYYSEGKKFPHRIYCIVTLLMLLMQYGMMAVNLMMESDDVDDLTANTITMLFFLHPIVKMIYFPVRSKIFYKTLAIWNNPNSHPLFAESNARFHALAITKMRRLLFCVAGATIFSVISWTGITFVDESVKRIVDPETNETTIIPIPRLMIRTFYPFNAMSGAGHVFALIYQFYYLIISMAVSNSLDVLFCSWLLFACEQLQHLKAIMKPLMELSATLDTVVPNSGELFKAGSADHLRDSQGVQPSGNGDNVLDVDLRGIYSNRQDFTATFRPTAGTTFNGGVGPNGLTKKQEMLVRSAIKYWVERHKHVVRLVTSVGDAYGVALLLHMLTTTITLTLLAYQATKVNGVNVYAATVIGYLLYTLGQVFLFCIFGNRLIEEVSSSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFTVSLDLFASVLGAVVTYFMVLVQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJF8</accession>
    <name>A0A232EJF8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_013668</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004011">
        <property type="protein sequence ID" value="OXU18496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJF8"/>
    <dbReference type="STRING" id="543379.A0A232EJF8"/>
    <dbReference type="OrthoDB" id="8188638at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU18496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="751" mass="86525" checksum="84289C4EF4478316" modified="2017-10-25" version="1">MEILQKLRESRKGEVSFMNKGERVHTFCDRFDQIITEHELSNDPEKLTEQEKRSTFYQVVIGVIPEIRRTDSAVITTTGKEMNMDDLRKVMVRIQEDNDANSKKPDSKEPTASRASFKNFRGDKNKCFRCNKTGHWQQDCPLTNLNRLFCYLCNCETDHKGDDYPINRLAEAEPTLEETEVKAEDSPEAIVEVLEAEQPPDELSMKMMVITGMSMTKTSKIKGVIKSANKNDFADIVIDGRGNLSLKNNISNENPIKLTNVIAAKVISENLLSLRRLIDAGFSINLDDKIFRVYNKENDKTIFEGIYEKPNWVVRFEVKKVTNKNNTMINESDNYSCIACLASVSEGDNSEYNTEASKEKESVIGREKSEEFIESNAENANSEETTTTECNACLMVIMENQPDILNSEVKQNEAMLWHIRLGHASLNYLKMLQKKEKILKHVKFDESIRDCEECILSKMEKLPFKQNKSRAERPLQIIHSDLMGPIKPTSWLGGKKYIMMFVDDYSRELSEHFMCDSGLPPSMWELAAEEAIHSYNITPHKSINYEVPTLKFSPKARCHLEQIRRFGCIAYIKLPKTETKFSSVSVKAILVMRQKHENISDMQIEFSENQSTKESQDAIECNFARYTKTSEIEEVNEDELGHILLASIQEDPISYKEGVNSEDKDLWIQAIKEELESTKKNEVWELVDRPKVQLNARLVTRGFKDRNIYDLKETYAPVSRLSLIRATISISNKEDLEICLRKKKCLWKYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJW8</accession>
    <name>A0A232EJW8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003950">
        <property type="protein sequence ID" value="OXU18601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJW8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6826" checksum="048EC24718E2768D" modified="2017-10-25" version="1" fragment="single">MRTIRAAEKNTPETDWFIHVNNAFCSKSRPPLVSGPMEADQSNFEEHGTDANLNSRRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKE2</accession>
    <name>A0A232EKE2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_009042</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003832">
        <property type="protein sequence ID" value="OXU18788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKE2"/>
    <dbReference type="STRING" id="543379.A0A232EKE2"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="212"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU18788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="635" mass="70874" checksum="9B4EEAD067CBCD64" modified="2017-10-25" version="1">MKTVYFFIKPQRRFLRKFCSLTIHPNSAAQVRYFKTDRSIKAELDRNPTLSTRIRKWIGLNTQSDSKLGELSGDEAISNAANREYRDIEKLSKLLGDKYAKLDEPQRIKVAFGEGYLAGRNQKPFGRVYKVLKFSQQIITTVIVLIIFIFFIATTEGSMFKMKLGNKSQVDPEEINVKFNDVKGVEDAKSELMDVVEFLRNPDKFSALGGKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFYAAGPEFDEIFVGQGARRVRDLFKAAKEHAPCVIFIDEIDSVGAKRTNSVIHPHANQTINQLLSEMDGFHRNEGVIVIGATNRRQDLDKALLRPGRFDSEVTVKAPDLMERKEIIDLYLGKILTRDVNAELLAKRTIGFTGADIENMINQAALRAAIEGAEYVTMDHLERAKDKVIMGPEGKKKILDEQENRLTAYHEGGHALVSYFTKDAVPLHKVTILPRGQALGYTQSLPNKDTHLMTKAQMLASMDVSMGGRAAEELIFGQDQVTSGASSDFVNATAIAEEMVRVYGMSEKFGFRVIRYPGEEGGIDYSASTKELIDNEVRRLLQESYDRAKAILKNHSKEHKILAEALLKYETLDAEDVKTLVSGKKLRHETANDVNRTVVDVPNNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKF1</accession>
    <name>A0A232EKF1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_016408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003801">
        <property type="protein sequence ID" value="OXU18837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKF1"/>
    <dbReference type="STRING" id="543379.A0A232EKF1"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000035">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF6">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU18837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="198" mass="22864" checksum="1B6044985C292916" modified="2017-10-25" version="1">MGNKVATFSEEQLEDYQDCTYFTRKEILRLHKRFREMADPGMVPRSMTPREASSLRLPLDYLARIPELKENPFRDRIGQVFTRTSLDPGQICDDDGICFEDFLEMMSVFSEHAPRDLKVFYAFRIYDFDEDGVVGINDLEHTCQQLVRGGLTDEEVSTVCQKVLEESDIDGDGALSFLEFEHVVTRAADFLSTFHIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELC5</accession>
    <name>A0A232ELC5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003580">
        <property type="protein sequence ID" value="OXU19157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELC5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="35" mass="4255" checksum="E789B66B7BA41F50" modified="2017-10-25" version="1">MPNLAELTRPLELLLKKNQRFKWGPEQDQKIQEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELF6</accession>
    <name>A0A232ELF6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003579">
        <property type="protein sequence ID" value="OXU19161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELF6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="7140" checksum="39B314C744980940" modified="2017-10-25" version="1">MRRLRMYYYFKLVNGDYFARHTNSDPYRDKAGVKSYDRIMLHQALSERCSLNSDQDKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM53</accession>
    <name>A0A232EM53_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_017048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003441">
        <property type="protein sequence ID" value="OXU19411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM53"/>
    <dbReference type="STRING" id="543379.A0A232EM53"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="28"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="306" mass="34981" checksum="C89543B454222A06" modified="2017-10-25" version="1">MSLNFNYGDDLDGTFSEEKENELSTKEYIVFLIDGTPQMYENDSPFLRSLETYRNIVRTKCSRNRKDKLGVMVFGTKDKNCDVEHLTVLQEFDVVTVDTLKTVQTILKGEANEYKKMASDAKYSLYNVLTHAYQTLLTSGSSLKTSNTIVLCTCNDNPCAEDSSERRRIQHLIATFKDTKTRLQVIGLSKSWNDEYYKDLQIIAGTFSDDFDYRRLKLNDFEQIVLNPAKSICRLPWKITPDIAVEVSVYNLVSTPTYPTKVKLEKGENEILDAVPLLQEKRSESDFLNSGPTDFVGNVCIMVDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMH0</accession>
    <name>A0A232EMH0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_008966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003367">
        <property type="protein sequence ID" value="OXU19537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMH0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="484" mass="54102" checksum="32E2BA3061D20555" modified="2017-10-25" version="1">MTEGDHYVANMEYQSLWKTRDEKIKRSATDAAFLIIFALLTVLWIGIGIHGFTNGDGIPTEVTIQVEKWMIRNKIMDALSYSKSACFGFIGFTVLLIALFFIMVRWVTKFTIFATLVVDGLGCLFVSYSFLMTRLFVIFTLSVMAWLILGVTIYALKKVGTKIVCKVLQDACKTMICFPSSLLIVLLELAIQVGVVAFTIGATVYLLFIRISTVRVEDESDEYSYLRRFGIETYRQEVIVNPPTYVRILLPVLIGTSLWITQFVGTFRSMLLHGMFSHWYRASDKKNISSTVGLRCLATTSRYHMGTVAFSSTIFAIIPVIGALFNSANSLAKLLRKRPSSLCALWFALLQSLSNASIMCISYGTSLCQSTKDGLQLVMRNPLKYIAVHAISYWVICYGLVTILLIAAGASYHYFVNQIIVDPNNFEQIQSFIFAPFIVVIISSSILAAMLIAILKNAVEAVTICFFEESNLTTTGLEDADHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMN9</accession>
    <name>A0A232EMN9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003343">
        <property type="protein sequence ID" value="OXU19588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMN9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18310" checksum="9F1CB67F9F5F2934" modified="2017-10-25" version="1">MRNLEDKKLNTEGKKLKNCNEIGGKIKNGGSKGDWRGGLTYVGDMGHSVLDLVIEIETEGISIIDEVRVITRTELDHLPVAIYLEENSIEAKIENDRNRERMERKLVWDESKRGGYWGTMKEKGRDITIEGMNTQDRWGQLYETIWETGKELGLVREGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENA6</accession>
    <name>A0A232ENA6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003200">
        <property type="protein sequence ID" value="OXU19816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ENA6"/>
    <dbReference type="OrthoDB" id="7700848at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112431" checksum="E5A2088E78C3F73C" modified="2017-10-25" version="1">MFLQVVKQEEQASSKVELVVLRQELALAEAKGESILSSIKTLIGEMLDALKKQPNVNRTIKEGLPKLQSKLDLLEEDRRSTIKAKRLLIDRVKGSLTQPPITPQIRSQKKAWERDLRQLLPHPKRGNKAFPGEIRRPGGRGQRRGGGRRVMDMASRLGLVVLNTGTTSTFRRPGCRETIIDVSFATERLVAHVRDWQVIEDYTASDHQFITFCIRDDTPLEVAPRRHCRRWNVDKMDTEKLALALERGQQTRVEIPDGSSASERAELVVGAIMRLIQRACKEAVPIKKIAXGVVKQEEQASSKVELVVLRQELALAEAKDESILSSIKTLIGETLDALKKQANVNRTIKEGLPKLQSKMDLLEEDGRSTLKAKRLLIDRTKSQGKRQNSLSPTDKPGRSKKKKKKDSSSKGESSQETQTTNEDWKKVENKKKKKNQSKEETERNPSNGQPGETISKEKDKRSATKKKAAPRKRRTEANILKPEAGKTYAEILSGIKAQVKPTDHGADIKNIRRSITGDVLIELGNTSGNKEGLANAIKTAVGTSASLRTLVPKAKLEVRGIDCCSTSQEIEEAIRKTMDYGEDLCEVRLTKPNKAAQRMATVTVTETVATKVLETARIKVGWVNCRVRRRQVIERCYSGKKPPGAHRLHAAPHAAGDLSERQHGFRRGKSTIEAVQEVVEVARSTESGNHFSRPICLLVTLDVKNSFNGPDLWNIYYDELLRLEMPEGCSLVGYADDVAVTIVARNMELAQLRLDQVMCRVRRWMGDHGLEIVLLTKKHIPKIQEVKIGELTVKIKPAVKYLGVTLDTRLTFGEQIRKAADKAGGDDTEQGDGQHWWPSPLHQASVAADCRVHYVIRRRGLGRFAAVRNPPQARRIGPAPMRTTSGSSYRTVSEPAALVVAGVIPIDLLAEERKFVHQRKEDLGHAKAKEEAREQALLSWQQRWEQETRGRWTARLIGQLSPWIGRHHGEVNFYLTQLLTGHGYFRAYLHRMGKATDPRCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPZ4</accession>
    <name>A0A232EPZ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trichohyalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002858">
        <property type="protein sequence ID" value="OXU20435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EPZ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601817" description="Trichohyalin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="69441" checksum="CEC3E5F90EB2675C" modified="2017-10-25" version="1">MARNIPRMVGMAALLLLLSGTATATSYPSDDQYSLRNHYRITRRSSDHETLPTVATDHDEDELERRRQAVSLTELLELWEPERREDERRPLQRGDIEVTTRGVERGDVPVIGKRRKLARRQAPMWGFAEDEGMLPSDEESRPAPLHPHRKHHRNPGLIETDAGNGPTRWRGPEEEMRQRTALKVDRRRFNGQRYDEEEQRRRLYEMRRTPEETQRRDAQDAGNEGETRRRQEEEQRRRPEYDLRRRQEEQRRHENPRQNDDREDETRRRQEEEVERRRADYEARRREQEQQRPNDNDRRKQPDNREDETRRRQEEEERRRADYEARRREQEQQRPNDNDRRKQPDNREDETRRRQEEEQRQRGRNPPADEGDTYEKRMQEWRKKKEEHDRLVRERELQRQQHHPQQVDPAAQRPEAQTKSQEELEKERKLQEYIRRNTPIAVPPSGSRDPASERLRENEQVRRAEHERRLEEERRRKQVQEESRRLAEXXXXXXXXRPPVPSPQPCVWAIVVCCQQRRQQVANQAMKITRCFEATNCPGASWDVDRRCSEANVRAANEEIREFYLKGQERNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ19</accession>
    <name>A0A232EQ19_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002867">
        <property type="protein sequence ID" value="OXU20422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ19"/>
    <dbReference type="STRING" id="543379.A0A232EQ19"/>
    <dbReference type="OrthoDB" id="5982705at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF273">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="239" mass="26016" checksum="7E43122C55341426" modified="2017-10-25" version="1">MESCGMTTIKYILFFFNFIFAISGLGIIIAGAVVLSDVNEFKHFLEGRILAPPIVLIIAGTIVFIIAFLGCYGAIKEHYNLLIAFAVALLVIFIIELAVGIAAAVFKNDFDGAMRQALQDSMSRYSDTSSESDKMAWDKVQMKFECCGIDSPSDWQTADPSKFSRGLPPSCCKTYTASPCSASPYESFSKGCFTELQMKVQKNAKILIGVGIGIAFVEVAGIILACFLAYAIKRENEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQL9</accession>
    <name>A0A232EQL9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_008477</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002746">
        <property type="protein sequence ID" value="OXU20638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQL9"/>
    <dbReference type="STRING" id="543379.A0A232EQL9"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10497">
        <property type="entry name" value="MH2_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="10">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="11">
        <location>
            <begin position="302"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="496" mass="54198" checksum="94534D40DA64AC6C" modified="2017-10-25" version="1">MDDEEGSSSSGPMSSLNSLFTFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGTPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSLLPFQQLTEPTMPHNVSYSSTGFNSSGTTAGLLPVLSNYLIGTGVNPTSPISSVGSVPSPGSATTNPTSPYGSNGLPETPPPAYSPPDDGSQHGPSPPPDSTVSSNSANSGGNGNAAMDTSTGSPEVAPVCYQEPLYWASIAYYELNCRVGEVFHCQSHSVIVDGFTNPSNNSDRFCLGQLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSAIFVQSRNCNHHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEVHLHGPLQWLDKVLTQMGTPHNAISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQU0</accession>
    <name>A0A232EQU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_000819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002716">
        <property type="protein sequence ID" value="OXU20711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQU0"/>
    <dbReference type="STRING" id="543379.A0A232EQU0"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="142"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="237" mass="26784" checksum="0B55837852A81E1C" modified="2017-10-25" version="1">MANDKMNTDATMQPATENKTSKRRHTSESQMEVDTVNGIEGKIKNKSSSKRVKNVEGTEVRKVPVPAHRYTPLKENWMKIFTPVVEHLQLQIRFNLKTRNVELRTAPETPDIANLQKGADFVKAFIYGFEVEDALALLRLDDLFVESFEIHDVKPLKGDHLSRAIGRLAGKGGRTKFTIENVTKTRIVLADTKIHILGSFQNIQLARRSICNLILGSPPSKVYGQLRNMAGRMAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERQ2</accession>
    <name>A0A232ERQ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002562">
        <property type="protein sequence ID" value="OXU21043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ERQ2"/>
    <dbReference type="OrthoDB" id="10028922at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1631" mass="184634" checksum="F71C26D8BF879D83" modified="2017-10-25" version="1">MGTGSYAHYGLLKGLLEQFRTLDQSKIPKEIALVLNIDGLPLSKSSSSQVWPILFKIANYPEGSCDPFVAGIFHGEGKPSNVNLFLEPTILEYIQLADDGFEYNNTVYKVFIKYFAADTVARNYVMCFPPHNSRCGKCEQVGKTVQHRRVFLENDSDRRTDENFRKDVPPQYENLLSPLEGIISLTEQVPLDPMHLLDEGVGKKHIKLLLNFYGNEPTILEYIQLYDDGFEYNNTVYKVFIKYFAADTVARNYVMCFPLRNTQCGKCEQVGKTVQHRRVFLENDSDRRTDENFRKDVPPEYENLLSPLEGIITEQVPLDPMHLLDEGLPGELVTHQVNEPTILEYIQLADDGFEYNNTVYKVFIKYFAADTVARNYVMCFPPHNSRCGKCEQVGKTVQHRRVFLENDSDRRTDENFRKDVPPQYENLLSPLEGIISLTEQVPLDPMHLLDEGVGKKHIKLLLNFYGNGADAKRRLQALNNEYIGFKVWVPSDFVRKTRTLDHINRFKATELRLAIMPILFQNKISNELMLHFNLLNCALRILYDSSDCIRNNPLAKELLTAYTIKQLVRKGSYPLAQIMNRLNEKSQLSNAKIDQSIPRGHFVLKNSIHSQLPNNYSRPPQKIQFYNFTLSNRKPDNCCYLKDDSIIVIKHICYSNDLPIILGFKYVNLTSIENYPIDSTLLGICKTNQLSTNLQAWPISSIKKKEMSGKRGRLENNDSGKNIKRARQRDNTDKQQLNAFYLDSSGNQVPTGVSFPKQQLSLISHKKIKSLSQNAFKENLKNAANRTQPTLPTGNSTAPPLTTTPFQKSSCASNNHDVQYADQLANILIGNTQNSANGNNKRQMIDLNQSFMAQHPAATSTHINQLHQNSTISVSPETALPRKKKGCPSTIVSGALLSDNKSMQSPDDTSENITKTVSNKTITNQTLQEHDSYPLSKSKSLELTTTGELVTHQVNDNGSFVPIEKLLTVNGNMLAGEVGSLPLIEDILILVQSPLMDTEEEIINNNPGTSINQDNKTITNQTLQEHDSYPLSKSKSLELTTTGELVTHQVNDNGSFVPIEKLLTVNGNMLAGKVGSLPLIEDIPILVQSPLMDTEEEIINNNPAYGDHADGTTPDKDDKRDPPYDLSDQDLSEDEEDKDTDDLSINGASNAEEGEGEGGRDSDENSDLNEQRVFHNADNRNHYQNPENQRTNNNNIAQLLEIERTTHNDNCCVGSLPLIEDILILVQSPLMDTEEEIINNNPAYGNHADGTTPDKDDKRDPPYDLRDQDLSIDEDDKNSDDLSINGASNAEEGEGEGGRDSDENSDLNEQRVVHNADNRNHYQNPENQRTNNNNIAQLLEIERTTHNDNCCVGCRNILLASVRLINENGLLLKSFLANNDRNRNRVQADNYNRLEFLPIDDTNLLKDFDKNLAKQDPENAELRKQFNNKVLDCGESDMKKLVWMIKVDEKTAIQNYNVPSIIAKIYVLRXASVRLINENGLILKSLLANNDRNKNRVQANNYNRLEFLPIDDTNLLKDFDQNLAKQDPENVELRKQFINKILNCGESDMKKAITTILPQIITDELGTKLVWIIKVDGKIAIQNYNFPSIIANKYNCVANDVKKRIKLWLQKSGDRIRANKKKMERMRELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES76</accession>
    <name>A0A232ES76_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-lysine N-trimethyltransferase SMYD5</fullName>
            <ecNumber evidence="2">2.1.1.359</ecNumber>
            <ecNumber evidence="10">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SET and MYND domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">[histone H3]-lysine20 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">[histone H4]-lysine36 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_010432</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54193"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="2"/>
    <dbReference type="EC" id="2.1.1.372" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01002479">
        <property type="protein sequence ID" value="OXU21213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES76"/>
    <dbReference type="STRING" id="543379.A0A232ES76"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10521">
        <property type="entry name" value="SET_SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044422">
        <property type="entry name" value="SMYD5_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU21213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="386" mass="44034" checksum="532CCD2117E9A36D" modified="2017-10-25" version="1">MDSNSRFQVRITDEEKGKGLFAVSSYKEGDIILEERPLVCCQFAWNADYKYLACDYCMKPLETAEENARRLSGKSDLILPFPECCETKKDSISECESCGTKYCSTECQNEAWQRYHQILCLQSRQNTEHHPLVQLKETWKQMHYPPETATIMLLARMVAMVNQATDKTAIISTFSQFCHRTINDTQEIAHNLLGEKFVGQIDVLRQMMQKTLNTELVPEWFTPNGFRSLLALVGTNGQGIGTSAFSRWVKSVSALDLPNDQRIQVDKLIDRIYDEMDEVVGTFLNNEGSGLYVLQSAINHSCAPNASVEFPHSDSRLVVRALRDIKPDEEICIAYLDECHLERSRHSRQKALSSLYLFVCKCDKCQQQASDPDVTSDEEFDDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES82</accession>
    <name>A0A232ES82_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002475">
        <property type="protein sequence ID" value="OXU21220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES82"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="45" mass="4734" checksum="068D353D682C270C" modified="2017-10-25" version="1">MAAGEAMLHLPRTAEVLYGENQSPESQQSVPKPSERAAAAAIQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESJ6</accession>
    <name>A0A232ESJ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_003960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002414">
        <property type="protein sequence ID" value="OXU21333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESJ6"/>
    <dbReference type="OrthoDB" id="7179992at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="380" mass="43828" checksum="88F0BD5721CB1ED7" modified="2017-10-25" version="1">MGGYIVPHRSFRVLRFLGTHLRIWPDDNKKCNFKTDVFFWFCVINYVLLLLPLFNALYLNRKNVVAASNTWIEVSGYAEVLAAFIYSKYKRVQLYVLLCEAEKYLLSKKVTIIKKYANTYAKIFLLVILFYLFTVFVYWSIEKPITGYEYLITTAVYPFNIRSHPIKGLIYCNQTFNLMYSSILPVFDGISVLLIFNCTHRLKILEHKFKLAKTSSDLSECVREHDDVSRTIKETNSIVRFLVFKTVFSFTSNVIPGGLQILNNVALSQSICQVCIILLVYSRIVLCAECAGNMTDAGEDLLFTIYSTLWYNEEPKIVSMKIFIIQKCQNIPAIHINGIMSGLGRKYLLTIMYSTFSYLTTLRTVTSDEKSYFATSRTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESP5</accession>
    <name>A0A232ESP5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002388">
        <property type="protein sequence ID" value="OXU21383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESP5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="141" mass="16597" checksum="736F50EE3218B378" modified="2017-10-25" version="1">MPAEDRGEEFRKPLQTRGVFDPTINHRRNLRSPMIVFPAESYITAREIDCERGNLMVLECLEEFYVFRGGERGRVYFEGTWESGFLITALTTGRYPNNEQPYSQEIRKKESICGAKIFLPSDRDHFQSVFKLMRQQKFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET96</accession>
    <name>A0A232ET96_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002312">
        <property type="protein sequence ID" value="OXU21562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET96"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="140" mass="16145" checksum="1CA2D833F0D6CBD3" modified="2017-10-25" version="1">MYFALCSLQRISSMLSNGYASAFDSTLTFRKSTQKEYYPFAFRTITTGLDQVLSEASLSSTRIYQEEETKATCGREEHPRDRLDCRAPEHFTASVSSKRMLNPFDNFLDGASWDRLMSKVISAQKMICFQNHMFELSDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETJ0</accession>
    <name>A0A232ETJ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002288">
        <property type="protein sequence ID" value="OXU21616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETJ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8906" checksum="FEA1647531794EAA" modified="2017-10-25" version="1">MCMLLRSQYIFCRMCSLSSVLVFLFKSDNLIKFQRVNVQVFINLLDDITHDLEILLFLTTTSRLSRDFWQLNIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUE9</accession>
    <name>A0A232EUE9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002136">
        <property type="protein sequence ID" value="OXU21971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUE9"/>
    <dbReference type="STRING" id="543379.A0A232EUE9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="25499" checksum="65F44CC789C70150" modified="2017-10-25" version="1">MQIEKLEKMRKCLLVQQLLLRTLINIKKLKSLKKKMILRRNVVGAYELVCNYFKVRNHEEFYQFTRMSVQNFDELLHLVGEQTCNYFKVRNHEEFYQFTRMSVQNFDELLHLVGERLQKQVCRRQPIPPEIRLTITLHYLGHGGSVSSEAVYFRVGKSTMYYIIAETRRRENGYYAQQIRELLRDAPAIIRNRFAKYFVSHVGSISWQYDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV46</accession>
    <name>A0A232EV46_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002057">
        <property type="protein sequence ID" value="OXU22216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV46"/>
    <dbReference type="OrthoDB" id="7700706at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014273" description="Peptidase M13 N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="90299" checksum="553CC6C3156F83F8" modified="2017-10-25" version="1">MAASLVLCLLLANAACLLAVPIQNVDYIDFDELLLNFFNEDMNKFIEDNNVDMLKNVQESRYECKNLYSHACDKRTETSIFSNHEFKQKTSEFYSTFKQKITDLLSNRDRNSGAPSVNLERQLYRRCMNLGSSDEQSTIKYHDDDKLSYVTDADENVRSNDIENEPVNQIFSKILKAFGHKNIFTKTWQQLDQKLAAIGFGHAFYDISVMADPYIPNKNIILLQPPSIKKWNSIKFIDTLSDIYVHFQIQLYEQCTENSSKTSDAESNELNLNDSDHESEDESEESSSKTKANFNSDEGPAFLESDETKDMALASKSYEVNSLCKPYQSLSRRDVFEKIINIEDEMILVFFNRLLKAMFDSISATNKEEFYTKLTIKEWNKKYNSINQRTTSKIDWFEVIKSEFEKVGITIDDTESIFIKNVPYFYKLAKYLKYHSNQIFDKAVRSKFIAENARYIDWDWMESVNPIDQSNFCFEQTQLYGVSQEALKSIKNDFSNLHVQIVATIINNIAHVLYHNISENVNLSDVQKTYMKAQLSAMTNHLLSNNYDTSDDHDSIFDDYYANFKATNDYFVDINMYRRTIKNSILKKLRDNRPLSYQYLPFDINEIENPRNRLVLYALSNIYIDSSKSPEFFNSSEKYYGTFGVKLAAFLYSLIVEDKFQTDVHDLHGSQWLNAHMTYSPRVVKCFVPENIVAYGYPLAYSTITEIFSVRIALEAMLNDSKVDSVHDFYKAYIESHCSSKEQKMMHKVLSNLAHVSTVFNCSDKSVEPKCDMSIFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVD6</accession>
    <name>A0A232EVD6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002009">
        <property type="protein sequence ID" value="OXU22319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVD6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="145" mass="16047" checksum="1B25CE05623B13B7" modified="2017-10-25" version="1" fragment="single">MVSFDAVNADYSNVTEDSTDENMPEAEEEEDSPPLIFRGVQILPTYMGSFPVAGFDAACRAEYLRAKLELLRAQENRAVIGSMRNRALFVSAAKYSVLLIYVLITEKNSLCVTDRESSPGGRKEKEISYTQSSVLRCGIPALGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVR9</accession>
    <name>A0A232EVR9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">hypoxia-inducible factor-proline dioxygenase</fullName>
            <ecNumber evidence="11">1.14.11.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_010868</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:48400"/>
            <dbReference type="Rhea" id="RHEA-COMP:12093"/>
            <dbReference type="Rhea" id="RHEA-COMP:12094"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01001956">
        <property type="protein sequence ID" value="OXU22458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVR9"/>
    <dbReference type="STRING" id="543379.A0A232EVR9"/>
    <dbReference type="OrthoDB" id="76265at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160082">
        <property type="term" value="F:hypoxia-inducible factor-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000005">
        <property type="entry name" value="Egl nine homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0847">Vitamin C</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="15">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="16">
        <location>
            <begin position="323"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU22458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="449" mass="51058" checksum="5387FDC8B0316088" modified="2017-10-25" version="1">MSAPAVSCAQQQQTSGSSCALNTSGCMVCGRNDKLLRCSRCKSVFYCTKEHQKLDWKHHKSVCSRLSDCTYCEKDSQNSEELLASGNHSRSKVPVQEEKSDSRKPRNNENKKAKNQSQRGGDTRNNLHTKEARDGWTSPITYEGSSEDTILGARAELLNPLQGSKILKSSANKPNTEMPEHRHHNGVKNFPEVRLRHEEEFLPSFLPRSRNNLEEIDDICRNVIRDMNLWGVCVVNNFLGTEKGLAVLDEVLSIHSAGLFRDGQLVSNKAGASDLKTIRGDQITWLDGKEKNCQNIGMLISKVDAIIMRANKMHNNGKLGDYTINGRTKAMVACYPGYGSHYVKHVDNPNRDGRCITAIYYLNRDWDITQNGGLLRIFPEGWQDQVANIEPLFDRILFFWSDRRNPHEVQPAFKTRYAITLWYFDAEERNEACRRYQRDKELNSKPGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVU2</accession>
    <name>A0A232EVU2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001950">
        <property type="protein sequence ID" value="OXU22475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVU2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="149" mass="15941" checksum="33A0F1779AC745DE" modified="2017-10-25" version="1">MLVTLQDQRSVSLGVQQVQQIALSPQLPKSLFNCVEVHCASSLGSVLPLQTRSDAGKGMSRPGSRSAYMPFKALLLFGEYGSRLAAARGTSGTVGALQRCLAGCRHPGACAREPAGGLQQQIVSKAYDFDKLEIVDTKKFSRCKKVAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVY2</accession>
    <name>A0A232EVY2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001935">
        <property type="protein sequence ID" value="OXU22510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVY2"/>
    <dbReference type="STRING" id="543379.A0A232EVY2"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15755" checksum="B90C310E808CE850" modified="2017-10-25" version="1">MHGKEEGSQMTLADQKESTVKTFNCEKNPKRGNLFPTKAVVRYLGVNIDDKLNYKQHVEIQLSKAKNAFWKVKTLLYSKHLKSRVKILCYQALIRPIITYGCPIWYNISASLMEKIRVLERKCIRACLNTYRSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW10</accession>
    <name>A0A232EW10_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GDP-mannose 4,6 dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23821"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01001926">
        <property type="protein sequence ID" value="OXU22539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW10"/>
    <dbReference type="SMR" id="A0A232EW10"/>
    <dbReference type="STRING" id="543379.A0A232EW10"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001053">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="356" mass="40125" checksum="67EFD5C12FAE096B" modified="2017-10-25" version="1">MATGDQKRVALITGITGQDGSYLAEFLIEKGYEVHGIIRRASSFNTTRIQHLYEDPNSHRQGKMKLHYGDMTDSSSLVKVISKVQPTEIYNLAAQSHVKVSFDLSEYTAEVDAVGTVRLLDAVQTCGLEKSVKFYQASTSELYGKASEVPQNEKTPFYPRSPYACAKMYSFWIVINYREAYGMHASNGILFNHESPRRGENFVTRKITRTIAKIHLGLQDVLELGNLDAKRDWGHAKDYVEAMWLMLQQDVPDDYVIATGETHSVREFVEEAFQFVGRSIKWEGKGVEEVGKDASSGQILVKVNPKYFRPTEVDLLMGDATKAKKTLGWTPTVSFQELVVDMMTADLELMRRNPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWF3</accession>
    <name>A0A232EWF3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="33">Protocadherin-like wing polarity protein stan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">TSAR_006376</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">Alberta</strain>
            <tissue evidence="31">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001867">
        <property type="protein sequence ID" value="OXU22682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EWF3"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001737">
        <property type="term" value="P:establishment of imaginal disc-derived wing hair orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016318">
        <property type="term" value="P:ommatidial rotation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048056">
        <property type="term" value="P:R3/R4 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120035">
        <property type="term" value="P:regulation of plasma membrane bounded cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035159">
        <property type="term" value="P:regulation of tube length, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15441">
        <property type="entry name" value="7tmB2_CELSR_Adhesion_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000202">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000173">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000013">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000021">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000029">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000044">
        <property type="entry name" value="Cadherin, EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000249">
        <property type="entry name" value="Starry night"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000256">
        <property type="entry name" value="Starry night, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056286">
        <property type="entry name" value="Cadherin_CELSR1-3_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF51">
        <property type="entry name" value="PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23592">
        <property type="entry name" value="Cadherin_CELSR2_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16489">
        <property type="entry name" value="GAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895592" description="Protocadherin-like wing polarity protein stan" evidence="23">
        <location>
            <begin position="29"/>
            <end position="3236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2515"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2548"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2586"/>
            <end position="2606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2618"/>
            <end position="2638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2658"/>
            <end position="2678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2699"/>
            <end position="2722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="2728"/>
            <end position="2750"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="269"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="374"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="491"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="598"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="709"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="812"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="923"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="1027"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="30">
        <location>
            <begin position="1152"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1396"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="24">
        <location>
            <begin position="1478"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1680"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="24">
        <location>
            <begin position="1720"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="1921"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="2017"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="28">
        <location>
            <begin position="2049"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="27">
        <location>
            <begin position="2317"/>
            <end position="2501"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="29">
        <location>
            <begin position="2510"/>
            <end position="2751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2807"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="3066"/>
            <end position="3091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="2817"/>
            <end position="2832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="2842"/>
            <end position="2852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="2861"/>
            <end position="2872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="2873"/>
            <end position="2901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="2929"/>
            <end position="2938"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1422"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1706"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="2017"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="2019"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="2038"/>
            <end position="2047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="OXU22682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="33">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3236" mass="355583" checksum="073C009A2FB6A3F5" modified="2017-10-25" version="1">MARRRPCSWINPLALLLLLGGFASLAQAYLAVLSSNLPAGTLVFEAGVPHLGGKRKYAASQDRTAWFALKLLKVHPHTGKVTLAKSLNCDGLQYPRLFTFYIDSTSSRLGRATIDYYSLPLRVLVTGCGGENVDLAATKGWMAETLASYAMPSTDKFTEVCLRTSQLVAALRDFLPHTALKQCETRWGGVADPRFLVEGAAGDLVSASEQCLVDPLWKISVSMTLRCGTTYLADAEHRLKIVFHHQQLDDSDLGRRVRRELRNQSPFFEQALYVAAVEEEKEPGVAVTTVKARDPEGGIVRYTMSSLIDARSQSLFNLDANSGKVTTTARLDRENVDVHYFRVLAVDDSFPPRTGTTTLQINVLDANDHAPTFESPEYEASVHESVPIGSSVISIKATDQDMGKNSEVEYSIVSTTGGGTTTLTEDQSTFRIDPRTGIVTTKTSLDREKTEVYTVIIQASDLANPESNRQTASATLVVRVLDDNDNYPQFSERTYIVSVPEDMDYTLNPVIAEIRATDADAGSNAAMRYAIIGGNTQNIFQIDSQTGDVILVKPLDYETVKNYKIIVRAQDGGMPAKSNTTQLLVRVKDVNDNVPRFHTTLFQEAVSESVSIGYSVLKVQAYDADEGPNAQIKYSIGSRDLSGGSTENFPVAVNCETGWIFTVKQLDREQCSKYQFVVVASDSGEPPKSASATVILTVTDVNDNDPYFEPKSYEAVIAEDDPPGTPVTTVTATDPDEDARIHYEISSGNTRGRFSITSQNGRGLITVAQPLDYKQEKRFVLTVTASDSGGRSDTALVYVNVSDANNYAPVFENAPYSISVFEDAPVGTTVLVVSATDSDVGQNAQITYSLSSDEDGAESQETSKFAINPQTGAITTTKPLDREVDKGYLLTITAKDGGVPPMSDTTDVEISVTDVNDNAPTFDSVQYQGAVREDVLIGTSVLKVTATDIDDGLNGRVKYVLENDGDGSFAIDPATGVIRTAKALDRESTARYNLKAVAVDRGSPALSSTVSVVIKIEDVNDSPPTFEKEKIVLYIPENSPIGSTVGEIYAHDPDEGPNAVVQYSIIGGEDANSFRLNTRPGADRAELISLVELDYESTKKKFELVVRATSVPLRSDAMVQVLVTDVNDNAPKLEDFQIIFNNFKDFFPSNSIGRVPAFDADVTDKLIYTILSGNNANIISLNKTTGEITLSPQLNTNVPRVATMDISVTDGINEAKATMTLSVRLVTDKMLLNSITVRLDEMTVEAFLSPLLGYFLDGLAAIIPCPRDNIFLFSVQEDTDVHNKILNVSFSAKRAEPGSSDEFYSTQFLQERVYLNRGILARLANVKVLPFDDNLCVTEPCLNFEECITVLKFGNASGFASSSTVLFRPIYPVTTFTCQCAKGFTGSREAYLCDTEVNLCYSNPCKNGGTCRRREGGYSCECPVGYMGNDCEVSLKQNACVPNLCKGGSTCINRVSGGFFCEKCPATPLDSVTPLCQLKSRSFGPTTFLTFPSLRQRHRLHLKLRFATEASEGLLLYNGRYNEKHDFIALEIVESQVQFSFSLGDEITRATAKIPGGVSDGQWHEVQVSYINRSVVVSLDNCDVSLALRFGERLGERWSCAGRNEQILEARCSDVTETCHRFLDLTGPLQLGGLPAIPSSFQIRNKDYVGCISDFHVDHQFVDLNSYVADNGTTAGCPEKRPFCASTPCNNGGSCREVWSGYVCECVEGYSGSQCDDEVAKPWRFRGNGLLSFNPLLKPIHLPWLTGFSLRTRDQDAFIMTIQIGQNSSIVFEIIGGRLAVLLDGADVIRSWVEIDDGNWHRVEVRWQSGQVSLDLDYRNRPIVQTLTAKMQGLYVGRTLIGRSDSTFNTELPFFSGCLQDIRVGTNQTILQRPIVQENVGSGCETDNTCTASCSESATCVTKWEESECVCTEGRVGQGCEKICDVNPCSESGSCVEKPNNKKGYECQCKSPEYSGEYCEIKAEQPCPATWWGSPVCGPCHCDESRGYDPACNKTTGECYCKENHYQPPGAKECIPCDCYATGSFGPRCDTITGQCRCRTGVIGRACTDCPNPYAEVTLKGCEVVYDGCARSFSDGLWWSRTKFGDTAIEDCPEPAEGKASRVCSDKLSGWQAPDLFNCTSEALIEQRYQLASLEANELTLNTYIAVKMAMELHKAVNATKTMYGADVLVAESLLVALLKYEDSLAGLNLTHSQDKDYVAHLVGIAGAVLQKRYADNWIRIESLTGDSPDKIMLTMAEYLKTLAVSQHDTYTSPFEVVDTNVVLGLDVVTSESLFGYEATEYKEDPSLSTARPTEADQKVILPDTSAFFVTPMHMGPSISFPKYNNYMPDPNKFDPYSKVQVPLRLLGIQSVTQGDLNVKNSLSNHKAVLSYVQYRELASILPKRFDDSVTIRWGVEVAVGSPIVTVSVLVPSETGYDTLTGIPLKSPVRIQLWLSEDDGYKTRINPQCVHWSTARGIGEWSRLGCTTEVDDTNMALGMMVNCSCIKLSTFAVLTDVLDLEYVPEPSLLEDVTSYSAFIVALPLLLTTILILALIRGGETNSNSIHKNLVLCVFFSELLYLVALKARHALIGNEFPCKLIAIGLHYAWLSTFSWTLVDTVHLYRMLTEMRDINHGQMRFYYTLGYAVPAIIVGLTIGVRADQYGNFYFCWLSIYENVIWSLIGPICLMVLVNFCILIMSVRAAFTLKEHVMGFGNLRTLLWLSVASLPLLGTTWTLAVLGASENSPTLSYMLSVSIVVHATFSLVGYCFVNGRVRRNLYLSLLKCIGKKAPLLDVSMVNGSSSQNVNNTGITRSGIAYSSTYGGTDANSKRVHVGVSTSSTTSRSTNKTGSSPYRSDTQLRNTSTSTSNYNSDRGAYMSRRSNHSTRHKRHETKQERSEQQKRRESESDSDASQRDSRGRGIDGTSSHSSEDETDKTVAQAAAAAAAVSSKNMGVSTQREPHNYLPNISGSAPQPPDSLNVLHCSSTDLFPNIKPIYAPRWSSQLPEAYLPSSNIDARGSQWSGGTMSDNEMASTKTASPNPLSYAELNLHHAKMHPDAENYSETEEKFHIADKYLYPYTSPEDELHQHQLHLQQQQQPSSHGPMSPTPYMLSVPSRILSSSMSHHSQTSNHDNFNNGYERYGSLKRGQALHKMNHDNLSYSDSRYGSLKRGGSLHGSYHDNLNTGLERYGSLKRGKITPTMLEDPSDYIMPISSRTLSGSLGHDLQQHSNELAALRQLQLQQQQLHYEHTIAETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWH6</accession>
    <name>A0A232EWH6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_009347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001864">
        <property type="protein sequence ID" value="OXU22686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EWH6"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13760">
        <property type="entry name" value="TGF_beta_BMP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000103">
        <property type="entry name" value="Bone morphogenetic protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF263">
        <property type="entry name" value="PROTEIN DECAPENTAPLEGIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="11">
        <location>
            <begin position="210"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU22686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="339" mass="38170" checksum="4014A9B8CFD62769" modified="2017-10-25" version="1">MDETERAKAIAGLETSLLTLLGFSKRPRPLQRSGQTHVPEQLKQLYRRQSASGVVDIAKRGINAGPANTVRSFVHVERPAKIGFVACVFSFLDESIDREKKKRDNEACIRFFEWDISRLFLTFFSSPRFLPTESELDDKFKSAHRFRLSFDVSSVPAGERLQAAELXXXXXXXXXIVRPGVRGKSKPLLRLIDSKILDLRSNASVSLDVRPALERWISKPPEHNQNHGLLVQDGRENCRRHPLYVDFADVGWNDWIVAPPGYDAFYCHGDCPFPLADHLNSTNHAIVQNLVYSTNPSLVPKACCVPTSLGSISMLYLDEENKVVLKNYQDMSVLGCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX36</accession>
    <name>A0A232EX36_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001791">
        <property type="protein sequence ID" value="OXU22915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX36"/>
    <dbReference type="STRING" id="543379.A0A232EX36"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38345" checksum="FACDE5288F69B9B2" modified="2017-10-25" version="1">MSLVVGYVWSIDSMYTSSCKWLINDFTFKKITNEVRSPIFHTTLLNQKYYWQLYAKNERKDDKDYLSVFLFNRSNIILNGSIRFTIFINDNPVEISSETNDCVIESNKGFGLRRFVESSTIKEAMLANFNHLVVLCEIKSNSEKTRKKKLQMNLEVQRLKEFHTWMSSLFPNPEFSDIKFTFNEPDSLPLHLHKNVMANSSPTLANIFRSRPQLRILEIKKVKCKVFIEMVWYAYTGKLPKCFEVDLFRELMLAARLYKMDRLEILCLAALCSEVSIENIFESLEIAQNYGVKQLQERASEYIAFNEIKVISEITEFPKLSNDDLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXJ7</accession>
    <name>A0A232EXJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">chymotrypsin</fullName>
            <ecNumber evidence="7">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01001736">
        <property type="protein sequence ID" value="OXU23082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXJ7"/>
    <dbReference type="STRING" id="543379.A0A232EXJ7"/>
    <dbReference type="OrthoDB" id="60866at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="259" mass="28093" checksum="09C7210EFC5EE406" modified="2017-10-25" version="1">MYWHQSALSAQSGITMKWVAGVILLCFTVAMQAAPRIVGGRDAPEGKYPYQVSLRAPTHFCGGSIINKRWILTAAHCVTGRTGNAVTVVVGSHLLNGDQGDSYKSEYIVYHEKYNGAMFVNDIGLIRVNRDIKFNDKVQSIPMPTEDFSKDDYPVVLTGWGSTRLGGAAPNNLQEINLKVISQTRCNGQMSVPITESHICTLTKAGEGACHGDSGGPLVADGVQVGIVSFGSPCARGNPDVFTRIYTFIGWMNKKMSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYS9</accession>
    <name>A0A232EYS9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001585">
        <property type="protein sequence ID" value="OXU23521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYS9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="10214" checksum="F8B98751DD3B89EB" modified="2017-10-25" version="1" fragment="single">MARAAVYIVRAGGKLRRWTPGFSVFGSERRRQSSPPEFPPGHPVAPAEDADVEDSTSVAAAAAKGCTRGVQSASCSCRRVARLNGSLSKCQGRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYV2</accession>
    <name>A0A232EYV2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_005130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GMP + ATP = GDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001595">
        <property type="protein sequence ID" value="OXU23480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYV2"/>
    <dbReference type="STRING" id="543379.A0A232EYV2"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000879">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="12">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU23480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="229" mass="26112" checksum="CA2B4DF6EC3FAE3E" modified="2017-10-25" version="1">MHILTYSQIPLSFKVLRLGLSIMLQKGPRPIVFCGPSGSGKSTLIKLLFNEFPDKFGFSVSHTTRNPRPGEEDGKHYYFTTKEDMQKQIEQGEFIETATFSGNMYGTSKRAIEDVQRAGKICVLDIETEGVKQIKTSSLNPLFIFIKPPSIPELERRLIGRKTETNESLQRRLSSARSEIEFGETPGNFDLVIENDNIDKAYQKLKDFILSEINQQNQKSEHRLITDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYX6</accession>
    <name>A0A232EYX6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001594">
        <property type="protein sequence ID" value="OXU23487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYX6"/>
    <dbReference type="STRING" id="543379.A0A232EYX6"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="301" mass="32945" checksum="70F7117F3CEF0F11" modified="2017-10-25" version="1">MSDEKKVTDQAEDSELNELLDSALKDFDKPAKTAAAQKEDASTTTVATTEEPKEETTVEEVWTEDFLKQAADQFQRNLEELMQNGGNNELGESFKKMAQTVAGAMSTDSSGGEDSAPVPDFQSAISQALKDLSATSENLQNVPNISEADLAAMFGQASLEDGGSDFLPFMQGMMQSLLSKDVLYPSLKDLVDRYPAWLDEKRSTLPPADLTRYEKQLDLMTKVCHELESEKEDDSEEVKKKRFESTLSLMQDMQSCGQPPDDLITEQQSVLQLDGEGNPAAPPALPGVLPGMDEGQNCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0H2</accession>
    <name>A0A232F0H2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="12">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_014506</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01001376">
        <property type="protein sequence ID" value="OXU24185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0H2"/>
    <dbReference type="STRING" id="543379.A0A232F0H2"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF15">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="470" mass="54092" checksum="1CB69B55390FDC39" modified="2017-10-25" version="1">MTSDSEKQPRSRKSTCSRYDDDQNLLDCYGSEGHRIRSGTDSFPNINERPVEDISIEFFYKPHTITLLLISICAVIYFAFVRDCSNVEDNLRAGLLSIVFFFLIISILTFPNGPFTRPHPVVWRIVFGCSVLYEIFLLFMLFQNYETVRKIFVWIDPSLASFHIDMDKEYGVNCSDITVKKIYDHLDVFAVAHFLGWAFKAILIRHLGILWAISVMWEVTEIAFAHLLPNFVECWWDAMILDVLVCNGLGIWVGLKICQILEMREYKWVSIRDIESTTGKFKRAVLQFTPGSWTTVRWLDPTCTHMRFVALCQLVIFWQVSELNTFFLKHVYEFPPSHPFVVSRLVLIGVIVAPSVRQYYMYVTDPSCSRVGTQCWVYGAIMMTEALLCIRHGAELFERTQALNILLWLLCQSLVSVLCVYGCVLWHQYFATDKNSSAAQQESRTEATPTGGDVGDDADDLEPEKDKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0L9</accession>
    <name>A0A232F0L9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DPY30 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dpy-30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001443">
        <property type="protein sequence ID" value="OXU23958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0L9"/>
    <dbReference type="STRING" id="543379.A0A232F0L9"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22966">
        <property type="entry name" value="DD_DYDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049630">
        <property type="entry name" value="DYDC-like_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037856">
        <property type="entry name" value="Sdc1/DPY30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356:SF16">
        <property type="entry name" value="DPY30 DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23356">
        <property type="entry name" value="DPY30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19909" checksum="8ABF54E761DA85B4" modified="2017-10-25" version="1">MSSESADKAKYKHSRDFPKQNRNDRASIELRTPAIASIRNVPTPHVYNVSSSSLHPHTRDVHICIGIQSSAAGRSERSISETDVSSAGAYLSRHLSAILPAALSEIALKKPVDPVEYLGQWLLHYRECEDRERRRREFEAELIEERLKLPRDETLVVIADDYREDQCEDSTSFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0Q3</accession>
    <name>A0A232F0Q3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001433">
        <property type="protein sequence ID" value="OXU23988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0Q3"/>
    <dbReference type="STRING" id="543379.A0A232F0Q3"/>
    <dbReference type="OrthoDB" id="8250698at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF56">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="133"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="410" mass="46569" checksum="CEA5E3E03BEA6303" modified="2017-10-25" version="1">MDDAMLRKIAKIVDTEFCEKILRKSENDPGIQVTDVLIKPATNKGDNYTSEMFRVNAEFVRAGSNDAEKKTFIVKVEPMDEGVRQDLVSKTSLFSTEIMMMTETLAKMNEVLGGNRPLNGRGLFTQKEDPPLLVIEDLAPLGFRMADRQAGLDMDHCLLAIRGLARFHASSVALCEKEPRQKELYSCGLFNMRQPVEMQSFFIEGTKQLGREIAHWPELDSNYSDKILKLADKMYEKGSAVSVCREDEFNVINHGDFWVNNMLFRYNEKNRPVGHIFVDFQMCVYTSPAIDLLYFFNTSLADDTLLAHEDTLLHEYLRVLSSTMSEVGCKTPPPTMAELKRMLRERALYGMVASFAILPVLLVDKSEAKDLGEIMGAEGDAYDNPAYKGKLYRQTMVRRLPKFDEMGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F171</accession>
    <name>A0A232F171_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001340">
        <property type="protein sequence ID" value="OXU24309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F171"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="172" mass="20146" checksum="C75D000A79F24492" modified="2017-10-25" version="1" fragment="single">MPIVLQRRRSATSRIGLELAAYRSRRRTPRHTADNGAPAARRTRDNDDVDGLSKLDWEGKKLVFVRLAIRIDTYGGMRWVLASDWKYTSIIYVSDSTIDEFRNGKHSLGVLAPLLAFRENDLLRFCGEFWVNVTKRGSSQDPVRERYRQIGWGYQQQQQQRQNKRSLFLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1I9</accession>
    <name>A0A232F1I9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001260">
        <property type="protein sequence ID" value="OXU24585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1I9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7070" checksum="811E69203B7C941A" modified="2017-10-25" version="1">MRRRRKSVVNSAKAFPTEIHPSRLRREAKNLTGGSLKQYKDDCCGDGGGEGEVGQAARAAAEQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F268</accession>
    <name>A0A232F268_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_011044</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001258">
        <property type="protein sequence ID" value="OXU24593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F268"/>
    <dbReference type="STRING" id="543379.A0A232F268"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="14">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="13">
        <location>
            <begin position="260"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="374"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU24593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="529" mass="60289" checksum="AD4B31882147843D" modified="2017-10-25" version="1">MINRTNCLIGFEKMQENHVAQMDGKSESESDDDWEEMNDEVQVLECLFCNIISNNLTDALKHLESAHNFSFAFFKSNHGLDVYSYIKLINFIRKNDIQPEELNEITVKSWESDKYLTPVIQDDPWLMLDVDELGDVPNSNEYTANSENEGVTLSEIHFAELQRTIQSLKAQLEQRDLACLLAKQQIEEMTKKAQKLVLDEDDALKPKERCVKNNTNDQGYFNTYSHFAIHHEMLTDKVRTESYRDALLTNSNIFNNCIMLDVGCGTGILSMFAAKSGCKKVISVDQSDIIYHAMDIVRENNLTNIIELKKGRLEDIDLDVEKVDAIVSEWMGYFLLFEGMLDSVIYARDHYLSPGGKLLPNRCTISLVGSGDTKRYIDLVDYWSNVYGFKMSCMKAEVVREPSIEFCNAQDIVTNVAEIQSFDLYKVTTDCVNFVSPFSLTVKRSGSLTAIIGYFDVFFDLDNPVHFSTGPHATPTHWKQTVFSLSEPISITEGEIVTGKLICRRHPKDIRGLIVTIQIKDSSQVYYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Z0</accession>
    <name>A0A232F2Z0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001155">
        <property type="protein sequence ID" value="OXU24952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2Z0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="345" mass="40602" checksum="0BC9AF94ADF8A08C" modified="2017-10-25" version="1">MYDIRRKENKIYVREDEKMKLLNKITTRKVINLRVSTLLQIPILCKHSIKRCPLQYIFNNACELKLWLNSRGRIFNLHRFKKIRFYKFLLDPLYSTSDSIGHPFVERLFLIGLASHQIVVAAQRAQFSFTSLKEKVLSRGQEKDSQTSTITTKYRCHQILPMVFDLNNSYGKIIHIELENTSVVITNFTDYAYRLDLSLATLIKHLNYWRTMRYAIRKDSGESRAKKVSYNNYCERAGCKDKLVNSENAQYTYFTAYNVECAMSDLDEMLRIFSLHSFQKVQPYRFSLHALYSTTDSIGHPLVVRLFLISLASYQNEIFLNISRRTCSTENTVLFHKSKVEVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F353</accession>
    <name>A0A232F353_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_016412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001176">
        <property type="protein sequence ID" value="OXU24857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F353"/>
    <dbReference type="STRING" id="543379.A0A232F353"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="520" mass="56930" checksum="FA69F01F3A249C7F" modified="2017-10-25" version="1">MPAPDMSANSRISKFKFQGKFDEARRRRTEVSVELRKAHKDNQLLKKRNINIEDEPLSPPSDQKSPIFNMSIDEIIAGMTSEDDQAMLQATQACRKMLSRERNPPINDMIEKGIVPLCVEFLGYHHNPMLQFEACWALTNVASGTSEQTQVVVKYGAIPKLVELLKCPAINVAEQAVWALGNIAGDGPIARDLVLREGSLSLLIALITPETSLSFVRNIVWTVSNLCRNKNPPPPFEIVKDALPLLNRLLSYPDKDVLGDACWALSYLTDGTNEKIQTVLDSGVVPKLVELLGSSEVTVLTPALRAVGNIVTGNDLQTDTIISAGALNYLGALLTHKRVNLVKEAAWTISNITAGNDQQIQRIIDAGLLPLLIHVLHMGDFKSQKEAAWAITNLTSGGTVPQLALLVQLGVLTPFCNLLESKDWKCVLVVLDGLNNILNAAEKMGEVDRVALVIEEVGGLDKLEALQTHENENVYQKAVHMIDTFFSDGEADPNLAPTTNMDGQLEFQATTTAPQGGFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F380</accession>
    <name>A0A232F380_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001060">
        <property type="protein sequence ID" value="OXU25296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F380"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556717" evidence="1">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="13977" checksum="777F2E3CE33DE529" modified="2017-10-25" version="1" fragment="single">SDLCVKFGYRVLGFLLSCFLYSDCTYAVQRGGFLGVFCECAKPRVWERTGWMIEGRTDAPGCSRVTLILHFSHTSTHVCQQCGSRLILVECLCDREGEEATSGLVNLVSGIQVAFAQRVKFYYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4C4</accession>
    <name>A0A232F4C4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000969">
        <property type="protein sequence ID" value="OXU25676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4C4"/>
    <dbReference type="STRING" id="543379.A0A232F4C4"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="65126" checksum="4F37D29800D94537" modified="2017-10-25" version="1">MESNRCKICFGETNPFNDPALLCQGECQCKIHIKCLRRGALPSNLIGDVFYDLRCTECSDSNDELLIRQKLSWLTTVILTLYNLREKSNGISRRGYFHWKSDISTFISNNWDYLFHKTVKKKKNWIGTISGTLSHYSGVFFQSGTFELGDQGWWKLIATDPPEVLVEKYYKVLEMKKQQQGKLKAKSVSSSPRSESRISNEDEYSNGAESFKPKETNPPVPAKPTYVEPINHSLPSSEVSDSIPSPCDDFADILDLDIEIPSFEFDFPSFNLAADTIAEELPFQTCNDLPDVFVSDCFQSGTSIAEEPVEDIEVTDTPIVENLQQNSEISKMEYSNEPDEQNENNDNDKTYDLPPPVPSSLVESIHRPWPWDESIKLNPDDVRPLMSEREEEYLLQKIEQYKHLLDRAPPSVQRLYRKLAVRKLKRQYGLPILNIDTFGKDLEFKALLQAKKKGNMVLDRFISEDVSIFFEQRLQGHCDPTSVHSPYTNRLLKPFIRRDTSSKPLWLRVTNELLAKVNKKNPEWTPQTNAPIDYSYIRPQHIPAINSLCSQFFWPGVDCNDRVLAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5C4</accession>
    <name>A0A232F5C4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001001">
        <property type="protein sequence ID" value="OXU25537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F5C4"/>
    <dbReference type="OrthoDB" id="10045355at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="754" mass="87697" checksum="DF2236E56112F5EB" modified="2017-10-25" version="1" fragment="single">MDEITCDICECSFIFENQAIFEPTAALFEPQSEHGMIHQPIIASFESESSDSESEESIIYDSSEEIDIKPNCLISKDLEDIVINYSAKISNFKKMPRKYVNIIISETKDLLRSIFKLLEKEVIREVDSKNADKSKNISTLLGSFSNSLDIIDSEFKRLENFRNLKAFIDPQSYHIGEREEYRNVNSIQTLIHIPIHAQFIPIRLVLEKFFELPGLYDQTIEYMKTLQSNSKIISNLVQADYWKERALTFESRIVFPLIIIVFLLIMYFDDYENNNPLGTHKGITKVGAVYINIPVLPPEYQSKVENIFLFILFNTLDRQVFKNPFIFTLNDQKISGIKETCVLHEINHFHLTQNVAVDAMHDILEGICXQKALIYDIAFLLQNFIYDRKLFTLEVLNTRLRGFDFGGRYNVNHPTELNEKSIKNGRAVMSSSEMLHFIQNLNLIIGDLITTNDEYWNMYLLLKELVNIVFSDILHPSTYKYISKNQEGKNTSQSTTSRVNITKTIAIKHQLXNDEYWNMYLLLKELVNIVFNDILHPSTYKVLESVIFEYLSVSKSLSNNFKPKHHFLIHYPTSMKLFGPLWKISCIRFESKNQEGKNTSQSTTSRVNITKTIAIKHQLNLCCRFVMKVSQPIFKSNCCKNKSIAELEDYKNILNLNQKKNIVSVKSVKYYDKIIKTDSVLVEFSFSGPIFHVVQEIIVDESKFIFITKKLKDCFYSEHFEAYQVFNVNDFDWAKVDSDVIHYCKIINMVLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5I6</accession>
    <name>A0A232F5I6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000883">
        <property type="protein sequence ID" value="OXU26074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5I6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="156" mass="18662" checksum="01EAAB8E4EF86399" modified="2017-10-25" version="1">MWRKRKKKEKSSEFIRAKERERERSESTMSQVSCDSQRCFFASATSTIPLMYFFLYFCVLRWLIQSTSLFLSCRPRVFVYTFVCVCVSDVSYTWMIVSELGQSVASVEFWQVSILNTRFPKKKIEKKNHKGFTMTDIRYTLRGMYFHGYNILLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5V6</accession>
    <name>A0A232F5V6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000910">
        <property type="protein sequence ID" value="OXU25962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5V6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646959" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8640" checksum="888D755682CE1EA4" modified="2017-10-25" version="1" fragment="single">EVRKRRRRGSLSLLLCSSLEISLLIALSLWSLDDDGSSCTHRNNGVYFWLRVYTYTYTHTRAADGSTQNILCRGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6F4</accession>
    <name>A0A232F6F4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000803">
        <property type="protein sequence ID" value="OXU26424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6F4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="11215" checksum="43A756B07E2C253A" modified="2017-10-25" version="1">MRTATMESYGLSAENKKSTIALLADEVKDILSKNQVILLACWNNASTTTRKSSCRITDELSRDFIQARAQQHCGIRRHRHARKGRPCRKFLSFFRACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F761</accession>
    <name>A0A232F761_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000750">
        <property type="protein sequence ID" value="OXU26696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F761"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="317" mass="35938" checksum="F2A322B0EC53657E" modified="2017-10-25" version="1">MADNMEEGNESDTGSSSFKIASSSISQNSPLMEDSRAQLPPHHNLLTTSSQNSDGTSTIHWPHLPKNTRSLPNSTSLEKILSQTNTGNNIVNVHSETASTESWIEPKRTAKNQKKPDTHGPQHRDSGYPQPFAQWQPNIAADHMAYTHPSRDTISWNQHILTRVKHAIAPSQRPYQDSQSLPPDRRRHQTTRRSPTARSAQEHWAKDSSKHSWRSKTEPKINHFLVQLSSNSDTNELTKIKNIAFQSKISFSRTEPKINHFLVQLNSDSDTNELTKIISIAFQKINWEPLKKERYFNAKNVRDWGTLAQTVNLGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Q0</accession>
    <name>A0A232F7Q0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000785">
        <property type="protein sequence ID" value="OXU26520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Q0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012443873" description="Kazal-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8181" checksum="D63518F08C7269FA" modified="2017-10-25" version="1">MKVVLFSVLIVVFASCFVQGEAAALDEGAGDCPCAATANIYYVCGSNGVTYTNPSLLRCAERCTRQTITKVHDGKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F874</accession>
    <name>A0A232F874_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_015680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000677">
        <property type="protein sequence ID" value="OXU27046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F874"/>
    <dbReference type="STRING" id="543379.A0A232F874"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF33">
        <property type="entry name" value="GLUTAMATE RECEPTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="282"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="11">
        <location>
            <begin position="545"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="806"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU27046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1132" mass="129799" checksum="4FA6A0177A4CDB8C" modified="2017-10-25" version="1">MEVFRGLAELDIRLSLMPISVDLDMRELMKVNYYRIGIFLDLDCEQSDFVTDQFISARLPFNESYFWLMKTIGSSAPLEMLDLLPLSINAELTLATTATAGAHRYELYDVYNPSYRHGGKLNVTRMGYWDRDEGLSLHMTQYKYKRRGDLRGMVLNFSIVVDFPPANVDMATYLTTPIQKHLDTMHRYNYALTLQLRDYYNFTMNLMRGATWGYLINGTFNGIVGDMIKGIVDVGATPFQFKPERMDVMDYTVQAYMARAAIIFRHPKRQTLNNSFLEPFSKQVWWLTAVVGLINWILLYLTIKMEQRYVGNVQGSTLFTQPESETFLITSAAICQQGLSDTPRVYSGRIVYMSLFLWALLLYQFYSASIVGSLLSEKPRFIRSIKDLAESSLEVGIEDMPYNHDFFRDTFSENEICDLQEIELFGPKHTATCTAKHSPFKKMITYGLRQIVEHGMTQRLGTVWKQKRPLCPESHSSTPTPVSLDEFSPALVMIAAAFSISIFIMLAENLVRRCLRRRRLLTPLFRRASAEKIDSCDETKVSQETDYFLHQGVKQITVFACWDLYERADFARKVVELDLKLAYSPTHPLVADMSKMLKVNYYKLGIVLDLDCPGSEEILRRVTSNRLPYNESYFWMMTTTSDVVPREILEPLPLSINAEMTVVLQGNDGFYSLYDVYNPSYRHGGKLNVTYMGNWSPENGLIVELTQYKYKRRGDLHGMYLNFSIVTSRHDASLQLCIDAAITMNLLRGTTWGYKVNGSFNGILGDMVKGIVDMENGETRRYGIYVILRHPKKNDLSNQFFKPFSREIWMLTTVVAIVNWLLLYLTMKVEQHYNKNYEKKNLGTLDTHPASETALITTAALCQQGLSDGPSLYSGRIVFISLFLWALMLYQFYSASVVGSLLAVPPRFITTPQALLESTMELGAEDIAYNYDFFATHPDPIVLELNKKKLMVNKHRKKAPYFTPEEGLKKVQKGGFAFQVDIATAYKIIEDTFDEDEICDLQEIRLLPPAHTATGTAKRSPFKKMVTYGMRQIVEKGMASRLRHVWHHRRPRCPESHSSLPTPVALKEFSPALLMFATGIAIAIFVMLSENLFRKYYYIVMRDPVHILPVQNGNQEKNERVLSARSVSDVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8F9</accession>
    <name>A0A232F8F9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000661">
        <property type="protein sequence ID" value="OXU27121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8F9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="41" mass="4561" checksum="4569383344026799" modified="2017-10-25" version="1">MLYQGTYLARSQGVGRILHAPNTNTSKHRRFTLESVVAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8I7</accession>
    <name>A0A232F8I7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000657">
        <property type="protein sequence ID" value="OXU27151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8I7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="355" mass="40616" checksum="68A19E0706F9E939" modified="2017-10-25" version="1" fragment="single">MFSNTAESIKIVDENMVFNNAEDVERLKTLSSTGNLPQRAEGLESLNDHTSSKSRNVVKKFARLYCRSCDKDVGLNVVVNSKIKTVCNECSKPMIFICNLCKINFDCLHNVYVHLKRSCKSVPAKFKCPECSYRAKRQNHLNRHIKVHMTKKCPECGKIIRNYTDFSRHQSNCLYEFDSESFVNVLTCDICGFFTKRKDNLLLTNCLLAIHKSRPYPAHAKVEENEEEEEEEDLEGKKEQPSVGPDISVTRKRKRQKGRKCQYLPLPNAQSMSSRFYNSTTTKRALNQVYINSNLRFSSTETCHADITSGTRGDSSQLREGERSLLCTELALKAWLISIRRRLAENLCAMQSSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8X0</accession>
    <name>A0A232F8X0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000633">
        <property type="protein sequence ID" value="OXU27294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8X0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="99" mass="11516" checksum="646CF354F58967DF" modified="2017-10-25" version="1">MRINTHTHGKRERKKAGDVERMQQHARNDPRAVCRASRRQSSQVRVRVTQKEEKEERTHAPTPGELLFSRSHVQLIFGLSHRSRACTHVLYACARLYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F956</accession>
    <name>A0A232F956_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_013848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000614">
        <property type="protein sequence ID" value="OXU27384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F956"/>
    <dbReference type="STRING" id="543379.A0A232F956"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="12975" checksum="6A44B641D58E8B46" modified="2017-10-25" version="1">MAENIPKPTGLDWVKLRQDMDGVSNSETPWERILRKCKENPLVPGGAAVTVGALSYGLYNFVIDRQQMQQKMMRLRVGAQLFTILAAVGGVLYSLPPEKRNLKDFIKSGERVIDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9J1</accession>
    <name>A0A232F9J1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000586">
        <property type="protein sequence ID" value="OXU27534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9J1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13533" checksum="9FB4840EF23F384B" modified="2017-10-25" version="1">MAGATNKRFQDETELDAAKDVMKQTSRIGFFRDQLLVSLGNAKGEAIMRLSPLNSLSIPYGRALRLTRMLTLFALLVATLLQRIPYAVGFLTNNFLKREYVDKSKKGKRERGREKILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9N8</accession>
    <name>A0A232F9N8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000678">
        <property type="protein sequence ID" value="OXU27027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9N8"/>
    <dbReference type="OrthoDB" id="8195753at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011968991" evidence="2">
        <location>
            <begin position="25"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="492" mass="52901" checksum="12AC7CF786B000B7" modified="2017-10-25" version="1">MRNFERVKCGLALLCAISAALVSCDDFDQQNNTKTVGLDDPGIDATVKAALENGSVSEVVVRKDLLLFPVNAPNLVIAHSQEIHAVPQQNSSNATDGKPVAAEVAEVNEYSLSQLVNNTDNDTTSQGIAIPVSSFPNGSENDSVLEPGKLLEIVSGFNLSNGVATEKVPLPSEVQDFSLPKHSIVELLSKSLPQADDAAPMIGSSSEAPSYYVGKRSVDDDDDDDEDDDSQSNGSESTEDDDDSQSDDADLEKRSAESDEKDDSSDSKSDESSATKSGSNSSTTTETVKKSTDSGDDADSSSTTENGSSSTTESATSTGIAKRSIDSDEDDSSSTTENDSSSTTESATSTGIAKRSIDSDEDDSKSDSSEESTQKTSTSTSRKETKRSAEEDHDDDGDDSSASNSTEYYDHVVSKSSKTADSQAESSSVQRSGKESLVRDSEDDMDVAEDMVFRPLFRYRQETLLRQRYPFYGRSRNYGNRYRYRADDSDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAM4</accession>
    <name>A0A232FAM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000597">
        <property type="protein sequence ID" value="OXU27488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAM4"/>
    <dbReference type="STRING" id="543379.A0A232FAM4"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="9">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="164"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="573" mass="64686" checksum="BC2B8C7B8DDAF8A7" modified="2017-10-25" version="1">MPRIRDELLEKFEFEEHSYNLLMSSIDARACYKPYEKSWFRGVRSSKFRHVYGAPAKREKCYDNIKITKNAHDSQFCAVNPKFLAIVTEVAGGGAFLVLPLDNTGRLDFNANRVTGHTGPVLDIKWNPFNDNVIASSSDDCTVKLWHIPDGGLSRNLTDWLVELQGHKRRVGYIEWHPTAENILFSAGFDHLVIVWDISKGETVSVIDRHPDVIYSMSLNRDGSLLATTCKDKKLRVFEPRSGIVVSEGVCHAGTKASKVVFLGASGRLLTTGFSRHSDRQYAVWSQHDLSAPLTCETIDSSSGIVFPFYDNDTNMVYLAGKGDGNIRYYEVVNEAPWVHYLSQFISGNPQRGLGIMPKRGVSTAICEVFRFYKLHATRGMCEPISMIVPRKSDQFQEDLYPDTVGTTPALSAKDWISGMNSPPVLISLKTGGSITTHKPRVYKPTHLASATDLNTKKKFAFLSTETVPDYRPKEYNEISEKSQKTSSNQSTKFHQLQQKFNNVALQNNIVSSTINDNKALETTDIPNNEAELRLAYLRQTDELRLVRRQLANSQLRVKELEEQIRKHQQKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBZ2</accession>
    <name>A0A232FBZ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000444">
        <property type="protein sequence ID" value="OXU28341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBZ2"/>
    <dbReference type="STRING" id="543379.A0A232FBZ2"/>
    <dbReference type="OrthoDB" id="10503496at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012692060" evidence="4">
        <location>
            <begin position="26"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="690" mass="79863" checksum="A0A4C777B2E8A65C" modified="2017-10-25" version="1">MISRMKSFVLLIFILQAIDIQPITAYHTFSSERLLRIKDSHFRPLVTKSFDQFIYVTFPMNYLEPRIRLEWEKIGYTPCEIGFNSITETEFPLSLNTLADGKLLLSLLQTTRDNSLSLEKYRGIFSLIIDPETCRFNSVLTALNNKTVKNMDIKESIFVLTGEKVFDIFLMAGHANCTEGTACRLRYDEEGKLIYATDFNLDVEDKDVDRWSVNSIRDKALSDGFFYTVLTKNETIVKRLDEELNVDGILELNDSFIFSDNNGAISRCRGLPNSELGCDLYDMNLGPRSGVAASRVEARTYKNYIRNIRMFNLPEGGAIIFLVMQVYDLPGSLPEAEMFSTYIQNIDRYGRPGRVFKFQDDICVPLSTVEFLLRHNAKIINSNHFMSDYTSCIESSIVEPLYDHVDLEMHNPNGLTAFHLAVRSDHLEALHRLFRRGADVNQRTADLIKSTPLQLAVEFASPQCVELLLQHGADVNAQDTVKYTALFRAATCFQYFNYVPDSQASKIALLLEYGADVDDVLLNSWMVETSKKLLKIMIRYVALRDQERAKWRNDSMLPYTDPELYSVYLDCQKETNRMRECIIFRDLSLYQFLKRNPRDLRGYVKNTVFVTRLMDHKLQKGFPNYQEMLMRRYQLVCKQSKLFAEAMKSLEIMLGFHYDYNHLVTEKIVACLRTRDMWNLIYATDLADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC94</accession>
    <name>A0A232FC94_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000483">
        <property type="protein sequence ID" value="OXU28068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC94"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="182" mass="20797" checksum="760F6EF39BA42B3E" modified="2017-10-25" version="1">MAEKVDMEQMVVPLTEAEYQVICGALGINNQQESTSEVQVELNEETPRAESSSDTPSEEIDIDDLLNCFSETYDAFCSKLTADNQFQQQHVPTPAYSEHCVASSLTNQQPQSQQIPSHWPTLYSVPKDADSLVFVSPKLYNCKFCRKHFLSRAALTRHMNNYHAKRHLRCWECGFFPKCIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCK2</accession>
    <name>A0A232FCK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000461">
        <property type="protein sequence ID" value="OXU28220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCK2"/>
    <dbReference type="STRING" id="543379.A0A232FCK2"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003128">
        <property type="entry name" value="Villin_headpiece"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02209">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00153">
        <property type="entry name" value="VHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51089">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HP" evidence="1">
        <location>
            <begin position="711"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="776" mass="87684" checksum="6F9D3A35644E5F4E" modified="2017-10-25" version="1" fragment="single">DDASSCSDESSGAEIFKSIPKASTAFCIWKIEGLRTISLGRTKVGTFLSDSAYLIYAASARDGALPYPGMPVTQSYKYFARNAQTKELKDSQTVRAVHFWVGVDCDSSVSGAAALRAAELDSQLGATILFREAQGRESSRFLAYFRQRLLAVEQPRADEDSRGASLHRVSGTGLPVLSELKPLDWSSFSSRDVILIDVRSRWVIESRPRFQLTHRLRISRSVVFLWLGSNSEPLHKSHALKMLDERKKNNNNEEEEETRVFVVEDGYEKTLQPEARKLLDEILEPSRRFVSPEPLVRTYPPSSSIKLYKCNEQTGKYKVAELKSGPIFRTDLESDSVFLLDRGEAGVWAWPDYMSERPRLAAECQLVDDGTGERSLWRSKHGAALEEVDDMGLLYAEACYVLRYKYGYGRRTRCIVYCWEGVHSACNEREAALEAACALAEEESAQLVRSSQGKEPAHLLQIYNGKLTILTGPHRSAPPKKYLVRVYGSTPYKSKAVERPLRASSLDSGGVFILFSTSPVVWSGSRSTGDAREASRRMAPPTAPLVCEGKEDDEFWTQLGGKGVCNMESVDYDEEEMEKHFYHLKTEKDVFIGDEILGFAQNSLLPEAAWLLDAGNVIWVWIGSYTAHKPLKEYVEEAKIFLYTHPASRDRNTIISVIKQGLEPPTFIGLFDNWNHNFLRDYRPLGALRSSVQEQDALINDIMAIKMASEFDNFVKYPLTILRNDPEKLPPGVDVSRKELHLTFDDFMSVFKMEPAEFEKLPTWRRQRLKQTAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD88</accession>
    <name>A0A232FD88_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi SNAP receptor complex member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_005362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the GOSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000410">
        <property type="protein sequence ID" value="OXU28602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD88"/>
    <dbReference type="STRING" id="543379.A0A232FD88"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24669" checksum="38695A25B018A0DD" modified="2017-10-25" version="1">METLYHQTNKLVQELQHLFSQLDKKNPNLDVAAVEHEIQTKLRNINSNCDRLDILCSKGPISQRQNAKMRVDLLKYESRHLTSALNKWKQTILSKQRKEAEREALLSRKFTTNDHVDIMIDHSLQHNTSMHNSINGVDNMLQTGFGIMDSLQSQRYTLKGAHKRLIDIGNVLGLSNTTMRLIENRARSDGFILVFGMIFTCLVIALVLIYVYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEW0</accession>
    <name>A0A232FEW0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000368">
        <property type="protein sequence ID" value="OXU28847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEW0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="328" mass="37107" checksum="DE4C44D054F8D9EE" modified="2017-10-25" version="1">MAVEEVEGVFSDDLLAAGTAVRGRLRDSMNLDEEEEEKTNNVFDIRHFLKLMWTAKYLYVSIIEIIIDQESCNKLLTASVPIKPASSIFVHQHNPFNESYDILPLTKNDQLFNAKLINLHGYTLTAGSFARDYFTIVDALSPETITWDSFSGSDFWLMKSIAQALHFTINITTASIHLTTDNVTSFILSKFKLLLSENITGIPRTGDEAYAIAQELSQPKNGWILSVMKEPILPSLSVVMLSKFSPYVNEFDQIIRNIQQSGMNIFWISDALRSYWKNKIKDGVDATNAGKFYGIIHGEQTIDYNTNEDDIVSNNNHSRMPTLMETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFE1</accession>
    <name>A0A232FFE1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">chymotrypsin</fullName>
            <ecNumber evidence="7">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_012939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000286">
        <property type="protein sequence ID" value="OXU29481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFE1"/>
    <dbReference type="STRING" id="543379.A0A232FFE1"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167139" description="chymotrypsin" evidence="9">
        <location>
            <begin position="29"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="71"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="329" mass="35955" checksum="83ABE8AE8E5307DA" modified="2017-10-25" version="1">MRGMRRSSEDYLLLVAVVIVCTWTDATARTSQRKCKEYAELVTREEVAPVLRMGVQTNLVSDCGIVETPLIVGGVKAKSNEFPHMVAVGFGKPPENSSSVDFEVSWECGGSIISENFVLTASHCLESKDRGPAIRIRAGSTLLKDPEPGYQERAVIERIKHPNYTLPARYNDIALLRLEKPLELSGAVRPACLEIEHEPVGKVAIASGFGKTAYDEAVGSNELMKVQLNYISKDDCERSYKIDIGGRQLPSGLIPSLLCAGVMEGGKDTCQGDSGGPLQRVLSEPYCMYSLVGVTSFGKFCAFENSPAMYSRVSSYVDWIESVVWPGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFF6</accession>
    <name>A0A232FFF6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_002446</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000291">
        <property type="protein sequence ID" value="OXU29432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFF6"/>
    <dbReference type="STRING" id="543379.A0A232FFF6"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000117">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase makorin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="232"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU29432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="414" mass="46964" checksum="13DFD9FA4AF7F2FC" modified="2017-10-25" version="1">MADSWTQNVVCRYFKNGICREGSNCRYKHTQGARSETTPSESGSSQGSSSSSYLHCRFFKQGTCRFGNRCRFVHSSNNQTESSSSETPSNSSLTPVEKNCSMEISLDAEEWVNAPEFVPSAANSSANASFSPENSASGTTAPLSYAQAVNPSSGQASYSSLDPLCPYAEASGICKKVNCTYLHGDICDMCSRPALHPYNEEMRKKHTNACVKQHEVNMELSFAIQRSREKSCGVCFETIMEKATREQRFGILPNCNHCFCLTCIRKWRKAKQFDNKIIRACPECRVPSDFVCPSMYWVDTKEDKDKLITDYKDALSTKDCKYFNKGRGKCPFGNKCFYLHALPDGTKTDVGPPVRQQRRNADNDIDFFRQLLLWDFMDERENFWLYNIDDLQDIVNIASDSEDSDWSEYDLYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFH0</accession>
    <name>A0A232FFH0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HDAg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000282">
        <property type="protein sequence ID" value="OXU29511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFH0"/>
    <dbReference type="STRING" id="543379.A0A232FFH0"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037517">
        <property type="entry name" value="HDAG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052828">
        <property type="entry name" value="NELF-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056557">
        <property type="entry name" value="NELF-A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328:SF4">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A NELF-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23553">
        <property type="entry name" value="NELF-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51838">
        <property type="entry name" value="HDAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDAg" evidence="2">
        <location>
            <begin position="89"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="527" mass="57910" checksum="29245F8A91641CA7" modified="2017-10-25" version="1">MANVRDSDTSLWLHNKLGTSNDSWTGSSICSQLNAEVLRNIKDCFPDLQTQVKLKLLLSFFHIPRRNVEEWRVELEEIIEVASLDSELWVSMLSEAMKTFPSTGSLNTDISDLDEHRPIFGDLVNDLRKLLKKQNDPAMLPLECHYLNKTALTSVVGNLPSPTKHFTLKRKPKSAALRSELHQKSLDAASNMKKNTAPTVPVRSRGMPRKMTDTTPLKGIPSRMPTSGFRSPALTSSPMTNRTPIASRIRKDGGIKLLDITEQPLGHAQAKRRKRMMEIEEQQKKAEEAKVAVSTTATPTTPTSEATATPDYAQGLAPISTPATPASTTAATTTSLPQPYSTPISSVPVAVVAPTPQTPATPTTPTAIVVTTQPVITPVETPPVTVQTVRPPQTVTQIRISTNTQQQANTANTRKGLSLTREQMLEAQEMFRTANKVTRPEKALILGFMAGSRDNPCPKLGNIVTVMLSENVEEVTQPDGTTVLMQVETHFQMNYTNGEWKRIKKNRRIVNDESASAATNQVDVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFX0</accession>
    <name>A0A232FFX0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000262">
        <property type="protein sequence ID" value="OXU29654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFX0"/>
    <dbReference type="STRING" id="543379.A0A232FFX0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="579" mass="66465" checksum="C9692DC94741C0F0" modified="2017-10-25" version="1">MEAYYELYYRLVDAVKSGSHSTIDLILGEEIFRSTLAWEDWHGGNRATLINTAVSRNDVETVQRLLDYGVSINVDEKRTRVIPPLIYAVVLGHERIAEILATRAKEHVDQRTCIKVHYKLVNGDSALHAASRCGFVRIAAMLLRNGATIDALNINNETPFHSMIGATITTEARLEMARYLLNQGARIDIGYKPTLLVAIEQKQLEVAHLIISMRYDAIRMTDSLGNGAMHYALKVYCPMEFMTMLVKKGMWVNEPNWAGERPLHVASRYRNYVMAKFLLDHRAYVNAISDSNETPLYLAAFNGNMPMVKLLLSRGAVINFKTNLEQTAFHAACQFGSLEMVHEMIKYGAKINGVSTYTQAPLYFACTKPSNDIVKALLESGANPNPVTDIPYETPLDYACRRGFEDTVWILLKYGVYINRLAYAYGIGTPYDYNITTMLITHALLAKHQVKCERFFTTYQDYPEFAQCQNELEVMKATEFYPKLTFYKMLVMQQQELTRMMRSVEVREAFEANFREDRFPMYKRYFTDKYADTKRMLKERDSAEEVLSSIFFTVLPFEAVTKILDYVSFDDIKFLAKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG84</accession>
    <name>A0A232FG84_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_015984</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000241">
        <property type="protein sequence ID" value="OXU29771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG84"/>
    <dbReference type="STRING" id="543379.A0A232FG84"/>
    <dbReference type="OrthoDB" id="8188861at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20101">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20102">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20103">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09582">
        <property type="entry name" value="SAM_Scm-like-3MBT3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000007">
        <property type="entry name" value="Lethal(3)malignant brain tumor-like protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF131">
        <property type="entry name" value="LD05287P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="669"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="775"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="882"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="1199"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="584"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="598"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU29771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1265" mass="141562" checksum="667D348E9D9BFF9E" modified="2017-10-25" version="1">MEEILVDDVSNKCVTEAPAAVVSTNNNNVVSVSSSSSSSSAAVDDPSTRVMSMLYIGQGKLHANQTNNNGSSQPLVHVIDKSQIAAFNQIVLQGLGQVSQTQISQPITIHRQVKTVTTPAAPQVQKHILVRKPNASGAQIMPLGTSQETQVQTQAGGLSRTTFLKRIIKPRETVVIPAAGPINAAQIPKQKLVIAPVISHVAQTPISTSSNLQNQSSKHMTNLLLPVNIPQQSASASKQSLNFKQNNINFKFSNGQLSTEPKSAITVLRESKTSNSTTNPPPLHPIAKMSLLNVSKSSSNSSESIKITENPDSAVITPIPKKEDNNLPEKRKKTISNILRGSGEKRYKKRSFSNSSSQDSGVVEVPNYTLNSPESEGEKEKKKDKESDDDITLIKVIPSEEKKMKRVLLSDDIKIEVIKQSIKKEVEVADKSEKVNGKANNEETKDQNDSNFDAAKVLDWKDGVGSLPGSTLKFCMNEFGLMEVVEEDESKQDKDENIGDKENVCFTQNSSKSSTPTIVNEKKPEDKKPRTVSADTFYCCEGCGCHGLASEFESPNSCSPSCTEYIEVLKQQKLRKEKELNKEMRAKKKRKRMLQEQQAKDRDKSKEPNSKSNDFDDKSRDSEDKSQDKEKSGTDEDTKDSTNAAAMDEESQGESESKQYRWQTGKRGFSWSKYLEHTKAKAAPIRLFKDAFPYGKNNFKVGMKLEGIDPNHPSHYCVLTIAEIIGYRLRLHFDGYAENFDFWVNADSMDIFPVGWAEKNGHKLQPPKGYVQSNFNWNAYLRICKATAAPKTLFSNKNSMIPTGFRVGMKLEAVDRKHSSLVCVASVADVMDSRILVHFDSWDDVYDYWADVSSPYIHPVGWCHHNGHSLTPPNYYKDSKSFSWDAYLRETQSVAAPARAFKQRPVCGFKRGLKLEAVDKRLPQLIRVATVEDCDAYTVKIRFDGWPENHAYWVDDDSPDIHPMGWCSKTGHPLEIPLTPDNLTDRPECGTFGCRGIGHVKGPKFATHNSASGCPYSPQNLNKIKTITDRLSLKHEANDVDEDFVAERTKYDKSERIKSERAEKRPLSYEEKSIKVENMKHEDGDSCDRMDNSERISNKWKNNSDGQTDDDEIIRKRKKRKHASDDTSLTSMLNSTQDSSAAQVSYASNIPDKQLRMELYHSVYNPGYNPLPDAPHIWAKHSNALNRVVSKQNTNPRRWSNEEVIKFIQSVPNCKEIGSIFRKHSIDGEAFLMLTQEDLVSLLGLRLGPAIKLYNSIVLLRKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGC4</accession>
    <name>A0A232FGC4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000282">
        <property type="protein sequence ID" value="OXU29508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGC4"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012466586" evidence="5">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="136" mass="14630" checksum="33CDF9E66173B78A" modified="2017-10-25" version="1">MKTFAIVLTLCIVGAYASTLKDDQKAKLREYKESCITETGADKAVIDGIIKGGPINRDEKLDCFSACMLKKIGIMRPDGSIDVESARAKAATTNVDVAKANEVIDKCKDLKGKDTCETGGSVFGCFITNKDFPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGF3</accession>
    <name>A0A232FGF3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000278">
        <property type="protein sequence ID" value="OXU29538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGF3"/>
    <dbReference type="STRING" id="543379.A0A232FGF3"/>
    <dbReference type="OrthoDB" id="6159739at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="640" mass="70789" checksum="4A1F175C226479D5" modified="2017-10-25" version="1">MTSVLPEEESNVTRLKLKSQSHAAHSSSKQRNASQDESRSFLTFSRENLSISTSDLEQGFSKPSRTRCCSRQTLLSCAALILALSCAGLELWKLRRVLENARDIESLKRDVETLKHRFLEKDLLDELRAFEEQIYKRAADGRLYGEGASDEEDLSSNPGSNNSDYDSSYDDSSGGTSSTSADYPTVTFAPNHQPSLSTISIPKLASTSSATPCTSKDLEEVLAVLRRAEAERGQAFEQSVRERERLIESERDRDQRRVVSEHRIQKGDDKPPASSGRKRKREATSAGETWRDKTFYTSHSQNCASNSTTTTKSSPHSRAELREAAAKLAASPDHVLWYQQPQKIESTAARDESRRAFHRVEYIHRRTVKVSSAAGKVAAGPLLAIPLGSSATDRYEIAGLFHQVDDLHLDIPDDRLISHQLTTGEAISIQDLPYLPRTRHAGSPILSAMTLNSIARSSPQMKLQLLVQAGAVVRADTRQLTRHKVAQKSSSGTDLRDVHEAPAGNRGAEKFVSLELTGIETESSGAFAGEILVVHLVVWFRTVGEISHTCPRYFSPNEKLKKSQFFAPPNEESLLDAELSEERLGAEEEDEADSGFPDGYRMVRTGYQVAELPGKLRVDQETTRRGDRGEAAQGVDAGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGH3</accession>
    <name>A0A232FGH3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000266">
        <property type="protein sequence ID" value="OXU29620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGH3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="26" mass="2855" checksum="B4C27893DF8812AC" modified="2017-10-25" version="1">MRSPSKIAKNGFLAVTPILSILQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHY8</accession>
    <name>A0A232FHY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000184">
        <property type="protein sequence ID" value="OXU30203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHY8"/>
    <dbReference type="STRING" id="543379.A0A232FHY8"/>
    <dbReference type="OrthoDB" id="7699712at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38617" checksum="0C67D7D5A5F7F6B7" modified="2017-10-25" version="1" fragment="single">TSSDASFIGWGAFCNGGKTNGHWIENHLVLLAAHFEINVFAKDYKNCLILLHRDSTTAISYKIQIKGVQYKNLITFTKKIRQWCEKRKIRFQATYIAAKDNKEVDTDSRCLQSNTQIEISNATFSKIPALLDQMPNTNVSWQRDPNSVAIVAFTIQHDGHLLEQDYPSGWNLVQRVLIQRGDLQPAMQISLSSMTESPYKRYKTYFRKWWAFVINYTGAAHSSISCYGSAILLLVSPEMAKDKRIKKFFKSLSKIRPFKSKYDFTWDPKIVQDYFSKSPGKIYHNIIFEKELIEIKIPDHITSSPNRNQSVLVLPIFRNNRNLRSINFTRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIL2</accession>
    <name>A0A232FIL2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000161">
        <property type="protein sequence ID" value="OXU30423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIL2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9555" checksum="58F76BD156B17A11" modified="2017-10-25" version="1">MTTSSAIQSDDGSQEISRKAGQRRRDQPRLHFARSFDSVSSSLRLAVSTASSLTAETVMRYALNDIMWTKKERFIFTTPWTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIS1</accession>
    <name>A0A232FIS1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_008934</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="NNAY01000185">
        <property type="protein sequence ID" value="OXU30197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIS1"/>
    <dbReference type="STRING" id="543379.A0A232FIS1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF175">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="981"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1045"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1088"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="867"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="820"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="841"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="844"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="845"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="845"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU30197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1170" mass="132927" checksum="A7294DEF93793720" modified="2017-10-25" version="1">MRGNSYCSAAGNRVAPTVDGTKCQGYGSSASSDYRVIELEPNNDPSDSPFPQNRITSSKYTVWNFVPKNLFEQFRRVGNFYFLVTAIVAASINSPISPLTSSLPLLFVILVTACKQGYEDLLRYRSDRRVNNLPVTVIRRKCSQEIRCQQIVVGDLVRVNRDDDVPCDLVILHSSESSGKCYVTTSNLDGETNLKTLLVPKTFADLEIEQVVSMKATITCQQPIAGLYTFEGRVQASIPREDSVEEEVRQGPLGIENIVLRGARLKDTDYVLGCAVYTGRDTKLSLNSKLSINKFSSVEKSINKYVLIFIAFLILEVCFCTVMKVIVESSARWDVYLGKLNSSIYANVHNDILSFTILFNYVVPISLYVTIGMYTLLLKFAYIIIFPKSITFMGSFFFSWDLRMYDESTEQPAIANTSDLNEDLGQVEYLFADKTGTLTENLMIFRRCFIDGYAYLEKDCNGNLYLLPPNGTETDVQKIGMWTPEIWHFMLSISICHTVHIAPDSQKAKAQMKRVEFRESFRLKKIVRLNSSLMMHPDLPEYQAASADEKALVEAAARCGVIYQGDGNKDEIKIDAKGTELRFYRLDTLEFNSDRKRMSVIVRDTTGDIWLYCKGADTTVFPLVHQGKPESAKISVDDFSMRGLRTLVIGFKKFTEDEYQRHSREISAARQTIGIDRTRRIDSAYLNVENGLTLLGVTAVEDRLQEGVPETMEKLRIAGIKIWVLTGDKAETAENIAFFCGHFKKGTKVLRLMDMKSIPMCYGVLTSFERKLKLDPFVQYGLLVDGISAGIALKNCPSLLRNVGMACEAVVCCRMSPLQKSQIVQLVKRARGRPLTAAIGDGGNDVSMIKEAHVGLGITGKEGRQAAMSADFAFAKFMHLDRALLVHGHWYYLRVAVLTQYFFYKNLVFITPQLLFSIYNGFSGQALYDSIFLMCFNIFFSSVPILVYGIIEQNYPDEKLLKFPQLYQLHKKNYLLSPSQFLLWIFMAIWQTCTIYLIAHYHYIYNPILFDGTPADHWCFSTCIFHLVTLVINLQLLVLSSYWTIPFVLSIITTELFFFAFTFFYSFWNLQYDGNMYRVFPRLVLSPTFWILTVLVITICLIPTYALVMYHNSRPLRIRGQLESREDSISEIIYSPAERISIASPVLPNRRSSTVVPWRGNFSCYDNKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJH5</accession>
    <name>A0A232FJH5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000109">
        <property type="protein sequence ID" value="OXU30896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJH5"/>
    <dbReference type="OrthoDB" id="7695469at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF144">
        <property type="entry name" value="SPINDLE AND KINETOCHORE ASSOCIATED COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU30896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1270" mass="144345" checksum="4760A72162065D3D" modified="2017-10-25" version="1">MSETKYYRSCFVPLCLNTAKNSPDKVFVSVPEDEKRCKLWFQLARRADNPTKSNIYCCQDHLNGHSSYITHLDWSLDAQYLRSNSKNYELLKKYYRSCFVPLCLNTAKNSPDKVFVSVPEDEKRRKLWFQLARRADNPTKSNVYCCQDHLNLKEDLLNYTRFTIFGGYYKLKPDVVPRFFDCQPDRKNARTLKRRSALMKLTYKRNVSEILSENELNKENPVKKVNLQSQQQFKSILGCATNVQATLPQSRSPLRDPSNDNDTLSVNENENVISDCESVQNLKEDLLNYIRFTIFGGYLKLKPDVVPRFFDCQPDRKNARPLKPRFALKKLTHKRNVAERLSENELNKENPVKKVNLQSLQQLKSILGCATNRDPSNDYDTLSVNENENVISDCESVQNVCTLTTNISSDIVSKDFLKPSVTYKDKDIQARSFYRSKYVQCDIRKPLIDSICSPIKTTFVDKATSPIRCNKPCEKVARTIVYESSSTSAIITTSPIELNDTFERLSEQFGISANYACRILSSTPDGFINFISVGYGGRVSDILLFEKCGIIDKLPSGCGVVAYRGFKGIQTLLLHKNCELIRPPSVSSNEKLSKEEALETKRIASLRIHIERVLRRLREFSMLQPCANLSSNYIKHLDNMSILGCATNVQATLPQSRSPLRDPSNDNDTLSVNENENVISDCESVQNVCTLTTNISSDIVSEDFLKPSVLYKDKVIQARSFYRSKYVQCDIRKPVIDSSCSPIKTTFVDKATSPISISPIRCNKPCEKVARTIVYESSSTSAVITTSPSEYEPSSDEKVEADKEEKSNVKMKLVNMTNYVVHANPKMHLGIVNEWFWIISVLSLETKMSSNYIKLTLMKIRLNDTFERLSEQFGISANHACRIFNSTMPKIEESIKRALPIPFRANYSHVQSIVDCFEISIHKPSNPVDQALTYSSCKGHNTIKFCISSTPDGFINFISVGYGGRVSDILLFEKCGIIDKLPSGCGVMADRGFKGIQTLLLHKNCELIHPPSVSSNEKLSKEEALETKRITSLRIHIERVIRRLREFSMLQPCANLSSNYIKHLDNMVGSVLSLETKISSDYIKLTLMKIRLNDTFERLSEQFGISANYACRILSSTPDGFINFISVGYGGRVSDILLFEKCGIIDKLPSGCGVVAYRGFKGIQTLLLHKNCELIRPPSVSSNEKLSKEEALETKRIASLRIHIERVLRRLREFSMLQPCANLSSNYIKHLDNMHSKDISPHKQIHYIGHQVMLQKWDDLLEERSHNICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJP8</accession>
    <name>A0A232FJP8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="11">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013226</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000123">
        <property type="protein sequence ID" value="OXU30760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJP8"/>
    <dbReference type="STRING" id="543379.A0A232FJP8"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="194"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="640" mass="72849" checksum="84D008960A04A510" modified="2017-10-25" version="1">MDSHQAESEKPAVSTISKKVSKLLETRPENDKDTIEALKELSTFFKENTVEDRRNLRSKIERRSLAINEEFIDAFKEVKSVLDNMHRDVAGMNECVQSMTNRLQTTKARTLQLIDQTTKLQNERFLLNLEIKKLTMQQEIANAFIKRFQLNADELAVLHGSSREDPITEEFFIVINRVQEIHSSCRILMQSGHQTLALDIMQRMTLLQEAGLERLYRWTQTQCRHIENEQLVPLLTKAMSKLQERPVLFKYILDEYCTSRRSVLVSSFIDALTLGRGHGSDSNSIEMHAHDPKRYVGDILAWLHQAIPVEKENLLTLLKACDKSDMSEQITQALSNITEGLCHPLKSRIEHIVAVEAPSTVLYSVTTLIRFYRATLKPVIHDSVLDAMFGDLLELSEKSFVSRLQRETRMALGERAEPPDTDLIPAPSVSRLLSLLNEVLSVASIAEDREKDMLQIVSCIIDPLLQEVNETASRLPTVDMAVYLLNCMHQIHSTLALYEYMDQRLERLQAQSDAQIDTLTSEQASSLVAHLNLGPIYTILQSHYQGPLSSIPGMDPLSIKEFTNKLEGFLVMPDVLLLPQISLLQSSTHRTNTQRRAFEVIGAIYKQLYDACHEPKNLYQNPGSLFGHTPEELLKMLFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJT4</accession>
    <name>A0A232FJT4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase B1, membrane-associated</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phospholipase B/lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Triacylglycerol lipase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="ORF">TSAR_010496</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="44 45" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="44 45">Alberta</strain>
            <tissue evidence="44">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40923"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:40924"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = sn-glycerol 3-phosphocholine + 2 hexadecanoate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:40975"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:40976"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40983"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
            <dbReference type="ChEBI" id="CHEBI:77619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:40984"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40979"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75585"/>
            <dbReference type="ChEBI" id="CHEBI:75688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:40980"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40915"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:34112"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:40916"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
            <dbReference type="ChEBI" id="CHEBI:77624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41104"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41107"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75558"/>
            <dbReference type="ChEBI" id="CHEBI:77623"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40971"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:40972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40919"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72841"/>
            <dbReference type="ChEBI" id="CHEBI:75158"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40920"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40911"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = 1-octadecanoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40927"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75550"/>
            <dbReference type="ChEBI" id="CHEBI:77097"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:40928"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:42605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="44">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000117">
        <property type="protein sequence ID" value="OXU30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJT4"/>
    <dbReference type="STRING" id="543379.A0A232FJT4"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01824">
        <property type="entry name" value="Phospholipase_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000005">
        <property type="entry name" value="Phospholipase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035547">
        <property type="entry name" value="Phospholipase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 43" id="KW-0472">Membrane</keyword>
    <keyword evidence="45" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 43" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 43" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="43">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00049372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00049461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="EMBL" id="OXU30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="488" mass="54415" checksum="860E2383F759D7CA" modified="2017-10-25" version="1">MATYAHTFFRRQVFYEPIASSFSSVGSRLCKQYTQTRISEKLPADRRICAAASSDRDSEVRETVDASGRKMRAYFVYLAVISLSLWTGPAGAASFTDMIRSLFQSGKNDLEAKGVFYPKVEYAVRKQRTVAPRVPFPCDLRSGRSAVPPTSVNQLRPGDIDVIAGLGDSLVAGSGALEEFAIGTFIEARGVSWCIGGQEDWRKYLTVPNLLKEYNPRLTGYSTGTGEFISREARLNIAYPVAATEDALHQAKILVQRMRSDPDIDIDNHWKMITILFGANDICSAQCYSPKEFSPIRYALHLRRALDFLRASLPRTIVNLIPAIDVTVSLRVPVRSLMCSILHPLYCACMHRGSQPDIAASKMSHMYQQAAEALVASGRYDTTDDFTVVLQPFTKLFNAPNANPRNAPPIDASLVTHDCFHFSQKGHALGANLLWNNMLEPVGNKTERGLPQIFERFLCPSERSPYIFTNRNTRHFLRTGSQEASPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK68</accession>
    <name>A0A232FK68_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000092">
        <property type="protein sequence ID" value="OXU31062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK68"/>
    <dbReference type="STRING" id="543379.A0A232FK68"/>
    <dbReference type="OrthoDB" id="6431884at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF28">
        <property type="entry name" value="SIDESTEP IV, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="223"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="322"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="412"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="578"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="907" mass="100137" checksum="967228300011DE4E" modified="2017-10-25" version="1" fragment="single">FFVEVSGVAESNVQLPCNLESEYNDVVKLVLWYKEPSNEPIYGFDMRNGRQFNDALLWSSPKALGRRAYFTTATKPAHLSIKELKLKDEGLYRCRVDFVNSPTTNQKINLTVIEPPGKPQILDGETMRPIVELEKRYNEGSDVKLICKTRGGKPPPKLTWFLENTVIDESYEHKPETGQTLNHLSYPGISRQNLKARFICQASNTNLADPLTAMLILDVNLKPLDVRILTKEPRVLADKKYEVECRSTGSKPAAVITWWKAHKQIDNLTKTYAPQNNQSLSVLSFVPSIDDDGKYLTCRAENPNIPNSALEDKWHLDVQYKPVVSLRMGVSLNPDDIKEGDDVYFECIVRANPKAYKLSWFKDAKEMKNNATLGIVLSDHSLVLQGITRHSAGDYTCLAVNSEGKTVSNPVPLRVMYAPVCKEGKSELVVGALKQETVSLICSVESHPAPLTFHWTFNNSGELMEVPQSRYTHASSTAVATGSPTTSQQQQQQQQQQQQLESQQLKEYQQFHGSRMNYTPSTEMDYGTVACWASNQVGKQRAPCLFQVIAAGRPYALHNCTATELSSAMELEELGLANKAAASLNGVAGTGLLVRCLEGYDGGLPIQAYHVEVISDEDDGPVILNKTVAASANGPTIEVAGLSTGRSYRLFLYAVNAKGRSEPAILEPVTLKGVAMYTTGNTDASAFSPLLLGLAATATLLALAVAGILAALYRKHSSRQSGSPKHAPIVCEPPNAGSTTPVHPQTKQAVDDIDPDIIPNEYERRPLTYTPVYKTPPQRRRGLRDRGGGTSPDELNSTSPEKKPMVQRSNLDLRADAALLAEHSPAPTIRFTQNHSLLGHQQQQQQQPLVGFPSGGVYGNQPTLADFKQMAFDAYNQRNHQNVRCSLSRSIFFIYSLSTTLHFSQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKB3</accession>
    <name>A0A232FKB3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein soc-2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein soc-2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">protein Sur-8 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000079">
        <property type="protein sequence ID" value="OXU31181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKB3"/>
    <dbReference type="STRING" id="543379.A0A232FKB3"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000031">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000115">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000281">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000450">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF33">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="209"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="445"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU31181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="582" mass="64923" checksum="886FD43102982BA0" modified="2017-10-25" version="1">MKEQDIPEYLEGCGLSATASDNMPEACDLLRESTNKDTSTQVKEQPKEKKLSSASISSSDTKKTVTVKHPESNKPKPTAKKGKPIQADLDVAKEFIRCRDEGFKRLDLSKSSITNLPNSVRDLTHLVEFYLYGNKLVTLPPEIGCLANLKTLALSENSLTSLPDTLENLKQLKVLDLRHNKLNEIPDVVYKLTSLTTLFLRFNRVRYVSDNIRNLTNLTMLSLRENKIKELPAGIGKLTNLVTFDVSHNHLEHLPAEIGNCDQLSTLDLQHNELLDIPETIGNLVSVTRLGLRYNRLSSIPKSLANCKLMDEFSVEGNQVSQLPDGLLSSLSNLKTITLSRNAFTAYPSGGPSQFTNVYSINLEHNKIDKIPYGIFSRAKNLTKLNMKENQLTALPLDTGTWINMVELNLGTNQLVKIPDDIQYLQNLEILILSNNLLKRIPASIASLSKLRVLDLEENKIESLPNEIGFLRDLQKLILQSNQVTSLPRAIGHLTNLTHLSVGENNLNYLPEEIGTLENLDCLYINDNANLHNLPFELALCTNLSIMSIENCPLSQIPPEIVAGGPSLVIQFLKMQGPYRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM76</accession>
    <name>A0A232FM76_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000043">
        <property type="protein sequence ID" value="OXU31609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FM76"/>
    <dbReference type="OrthoDB" id="8930856at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026163">
        <property type="entry name" value="Nckap5l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21740">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21740:SF8">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="744" mass="81682" checksum="C97E905220A8B0C8" modified="2017-10-25" version="1">MEENSRGLLQHKQRAEQLKQEKSALTLSYEARIQQYQSQVSKLQLENESMRGQLRGLEAACAGEXXXXXXXXTLETEHVALARDADAQRRQYERCLDDVANQGLREEIGALQRRIRELEAQNRALSGLLAXXXXXXXXSTMSSDVQAEGARQEPARGLEDLKEASDETEADLSPDARLVSLDAGDPDVLFLPLNLTLGLNPRHSYPPTKDLLQQGYGNYQHVMRSFSDSHLCLKLTATANIASYPIASPAGGSSSLLLVEEDGWDAEYVQQWLRLDDSRSAQQHRDLLELEYDRAELEDWSFSLSSEDLAPSDSSNTAHQWKEPALTPALPAIKEHNQLELEEDASECLWNGASYLSSKRSSAALSGCSDEPDSPSVGTDFTRDFYRLVKFESTKSLASTSSRGGKTLPDREQALQSVLSFIAEQQIYLAEMPSDPGARPFSADPADATPDAVNSDDMSDEAKDGFTEKSNQDLLDEIPVPPMAPEERIVSAVACNGGVSYTSVQPSELGAVPEEDEEAATSSTPSTVVSPARASVFVEGRDRSLSFHERATSKDVIDELNRMIRSGDDNPSRQDSHVALEKLDLACCCPTGWVHVERDIDFTDPKARANLLDVMLASSESSSATSSSGSAGSDSGDEPTDYRHLHRLHRYRRQKKASAVQAQRVLRLPSNWGSARPSIIGRGGEFFVRYGDKEREAVASFDFLNDIPVVQHRYSAVGSSDSELTSGSLPDLVDSPDRMKVSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM79</accession>
    <name>A0A232FM79_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000023">
        <property type="protein sequence ID" value="OXU31856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM79"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="39" mass="4493" checksum="42B8BE15DE180CB7" modified="2017-10-25" version="1" fragment="single">NPQVSPIVIKVVLICTVRLARERSECDKHGAKKNYFSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FME5</accession>
    <name>A0A232FME5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000037">
        <property type="protein sequence ID" value="OXU31690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FME5"/>
    <dbReference type="OrthoDB" id="6351205at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="21329" checksum="56B694463B4E0155" modified="2017-10-25" version="1">MKARSLLGLSVREGRQEKYREYLKLNNMTMRFKVRRKTLPMVFDDKMTTHSFLSLETTGMFQDGRIRLRCFAEITPVYKASASKEIVEEGPYLASSTGDASPHSRRMFVQRNPCPLRYHSNFTTRSLVAQPQWTAIPNCLRSISEQEALKMVKVIEMSLQVDNMVVLLWNLLEKQFRICLMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMR6</accession>
    <name>A0A232FMR6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000021">
        <property type="protein sequence ID" value="OXU31873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMR6"/>
    <dbReference type="STRING" id="543379.A0A232FMR6"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="355"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU31873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="535" mass="56401" checksum="FD49B8CC14EB92DB" modified="2017-10-25" version="1" fragment="single">SSSAATTPGTTSTTISISTTEQETSTPEVSTVVITESTSAATSPSTASSTISTSTTEQETTTPEVSTVVITESTSAATSPSTASSNVATSTTEQETSTPEVSTVVITESTSAATSPSTASSTISTSTTEQETSTPEVSTVVITESTSAATSASTASSTVAPSTTEEETTTPELSTVEITESTFAPTSPSTSSSSVLTSTTEGQSSTSEGSATPEADESTVSPNSSIGTTLSASTEKTTPLLPESTTVGTSGEYPSCANINTSEPVYLPHPKVCSKYYECYNGVLILRKCPNGLHFNPSTRACDYPQNAGCLKETTIATEPTSLVTSATPVSSEKTSVSTTPTSRPTTSKITSVVPSECPATNGKYAVHISHESNCSLFYTCDYGRKILQRCPPGLRFNPFKQVCDWPRNIKRPKQSPVISGVQRDLEIPSPSLSRKKETPRRFSQPRSDRIFKQHMKGIMRIRAGERKKAKLFTRVRLSSSSGSRKEANDSRSSAGEDEAHAVSQGEEKSDNRLCIMAKDILSIYLSSLDKIHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN66</accession>
    <name>A0A232FN66_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN66"/>
    <dbReference type="STRING" id="543379.A0A232FN66"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="6909" checksum="DBF29018F29FBA92" modified="2017-10-25" version="1">MYHFHQKETGSLEATKQAHILIIALIKDPDVDILQMLPKSKPASASMTSWDKSISSTIKNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNF3</accession>
    <name>A0A232FNF3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNF3"/>
    <dbReference type="STRING" id="543379.A0A232FNF3"/>
    <dbReference type="OrthoDB" id="10071877at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="714" mass="76679" checksum="6618651944C82E45" modified="2017-10-25" version="1">MSQILPVRSNSSIKLLGTSVPRVGSSRINSNTEKKTASHVTLPSNTKTTMSYTSAIMTAGRTSKIVTTNTAQTFAAKLSEIYTPPQSCSTLQSVNQCNQSSSNVINIVKQTITPNTSVALASTSSVNQVSHQQLITQSLTNAGPSVLVVSPSATSSQCSGKLKFSSNSVSLSTINSNPTNNQPCLIMTSSSSISSAKFLPTVSQAVTLQQFRSSTPIVGVTSEKCHTLSSNVPLEYSLFNDTFSKVTQQSMWGSKEIETQKSINFATIAGTGISVSSSTAPSNTFIDTSSMEVDASKAPGYRGTSMCSPTSNKSSANNAGNSTVTTSSLNSTASSPVQQVNIQSSVNYTGTHTSIKSPVNLSATKPHVTPKSMEIDVTSITPFIRPVFHGNIDTSQGITSGLKTCTISAISHNNLEANIYNESNVGYENQNLNSNLLNIIPNENQTNNQSILPIHQHIQSYPQTVAPSSVVTTTISISRLNPRAPDFSSSMHLNSKPQATMFSPVTPMHPNIFSTTSAQPSTTVIQSSNLAILGNFNFNKYQSPAQRQSNVNIPTCIQNRWPFVPPINYSSHQDSLANFPDHIANLSVQSGNLELINLENGSISPAISPSSTGQVLSQDVSQMQIEDRKIPRPIGTERTWKNYSTGIGPAGDSDNITWVTNNEKHINSWSGISSNTDRNQLYCSNTTFNRISASDTELHQIMETSYQVICYIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED25</accession>
    <name>A0A232ED25_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01009040">
        <property type="protein sequence ID" value="OXU16247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED25"/>
    <dbReference type="STRING" id="543379.A0A232ED25"/>
    <dbReference type="OrthoDB" id="7699899at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="261" mass="31248" checksum="FA1E1EBF1C6B3A3A" modified="2017-10-25" version="1">MQQMDEDAVEQIIEATPNKQLTDRRQKYRDQNREEINRRRRERYHHQKNMQQIDEDAVEIIEATPKKQQRKNDSNLDIIQEISHDFNSVIQQHNTQDFQERHNIISVHNNEGRNRLQTIVTLNAAGNSNIYSSFQSHKFAHKYFNENFISNEFGHACSICDRLWLERDLKKPLPIHENIINKIFDTPDMTILNICSTCKSALDKNKIPNFSVYNGFHYLEISHNLPKIDFLTERLLSPRIPFMQIRRLRHFCSWISYHQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDE6</accession>
    <name>A0A232EDE6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006567">
        <property type="protein sequence ID" value="OXU16379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDE6"/>
    <dbReference type="OrthoDB" id="7701518at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="225" mass="25916" checksum="AF053A023234AD1F" modified="2017-10-25" version="1">MRQLQESHTFLTVYQSVLCILQDLRHVHPDLRIKVSMENQQNDQSTQSTPKNIPTFTATVKNYASVSQKHLIPKREQGLIMDCVQDLNLTDYACTIGNIVQPKNVLYASRISINRICLYLSPKELVTDLTDKYQTVQIENKEVNIRPLVTKQKRIIFSNVSPDIPNFVFENILYKLNVKRSSPVITLRAAIAREGYSHVASFRRQVFVNPTDVELIPEIFKTTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDH3</accession>
    <name>A0A232EDH3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006390">
        <property type="protein sequence ID" value="OXU16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDH3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="13290" checksum="F308C856F8EDD77F" modified="2017-10-25" version="1">MTDLITQIWEVGTWKSDCNLGFSCNPVTAQFLAQNLVNIPVALDALRHLRVRSPDMTSPDFYLWGYLKDVVYEHETTTREDMIHRIQTACENIPRAVLLRTVEHFQQRIELCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDR5</accession>
    <name>A0A232EDR5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006056">
        <property type="protein sequence ID" value="OXU16472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDR5"/>
    <dbReference type="OrthoDB" id="7693491at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="19392" checksum="4F2EBEF7AEFB19D2" modified="2017-10-25" version="1">MCREVVNVEEMYVPNFDELKINYPGNFMCLNHGIQGINSSRDCALNHAYVLRKWLHSIAGDITQDSAQKFSDALYCKLNSRIRTATSSSIYATHEEDHRIVQHWIVKEPHRFEELATGLKRTNDYISNHFHGIRWHEGDITIEQLQYHLQQIAKVAIRIFTRGHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEV1</accession>
    <name>A0A232EEV1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxyisobutyryl-CoA hydrolase, mitochondrial</fullName>
            <ecNumber evidence="5">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_011801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01005214">
        <property type="protein sequence ID" value="OXU16873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEV1"/>
    <dbReference type="STRING" id="543379.A0A232EEV1"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="12">
        <location>
            <begin position="48"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU16873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="399" mass="43727" checksum="F816CD815B971DA1" modified="2017-10-25" version="1" fragment="single">IKNATMRLSCVSRLLGARISVRMFSAASGTAASSEESDVLLQEVGSSGVIVLNRPKALNALNLSMVQKIYPVLKEWESSKKLVVIKATGDKAFCAGGDVKSLVTALGQPGGDQLGKDFFRHEYTLNHLIGTYKKPYVALIHGITMGGGVGLSVHGKYRIATEKTLFAMPETAIGLFPDVGGTYFLSRLKGKLGLFLGLTGHRLKGVDVLLAGIATHYVPSEKLEAVTQELLENNSNVDEILKQYSSENVEQKFSLSPHIELMNECFSAPTVEDIISRQVIKQMIMLQLFQLLEANKSEWAQQIAETLNKVSPTALKVTKKAIEEGSNKTLAESLVTEYRLACACLNKDSDFAEGVRALLIDKDQNPKWNPKSLKEVTNEFVEQRFAPLPSQNELILSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFM8</accession>
    <name>A0A232EFM8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004998">
        <property type="protein sequence ID" value="OXU17128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFM8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7646" checksum="D5558630A3C08CAE" modified="2017-10-25" version="1" fragment="single">MGINADLYDYQNTETNTFYVATTSSVPYCARLRNNANVYQQYNESNVIQTKFFNPDQKTILIVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFU9</accession>
    <name>A0A232EFU9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004921">
        <property type="protein sequence ID" value="OXU17239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFU9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9696" checksum="F29431829A5D2ADE" modified="2017-10-25" version="1">MKLHLEPEQEKIDEEIPRASFKFYFDLDINFCMRQLESKNIISLYYKKISPPLSAPLFSAVVMGIAALPRNRFAFMKYFLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFY5</accession>
    <name>A0A232EFY5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004921">
        <property type="protein sequence ID" value="OXU17238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFY5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10689" checksum="07747B5DE421E0DB" modified="2017-10-25" version="1">MPMVVNIDDLQPLNFDIDEYIDQLLNSQNTNKDQGNHKINQTRQLAKQLIREKIKMFEKYIEETSEEDPYGIKRLFQEQNEKFKTKILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG26</accession>
    <name>A0A232EG26_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004870">
        <property type="protein sequence ID" value="OXU17319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG26"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="10969" checksum="F1B4A6CFAA0D5418" modified="2017-10-25" version="1">MKLCSIEKFGRLCSEYSLYSTFKRNSRKCLDRLSFPMLRAVLLSAQYVTDKGGPIIFRPTPEMVDSMKSQSFNPRNPVMPKKNKIFLRQNMGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG87</accession>
    <name>A0A232EG87_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004821">
        <property type="protein sequence ID" value="OXU17370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG87"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="643" mass="72834" checksum="512E5DB4772D478E" modified="2017-10-25" version="1">MFGDEVLITESHPITPVLFMHKVFSENEIHSGEKYGPLGHEKFPVKSAISYYMKYEFPFENENIEPDTKMKISNPSHGKTVPIQIPATKDSVVGEAYLRRITTVPGVYLGEAAVTNENRYCYAMAINTRDDQVEIEITPQYLEPFDMSDDDDFFEFPLEGEPIINQEDREKFIMDKVQQSYHTRQGLKQIQRIVTKYSHLFYLPGDPAPRTNRVRHKIRTTDEEPVRVKYKRGSTGQDEEKPGSKNAVLTVPKGMEGGQANLDVSTVAKRLKRRKADLSNIEPLITTSEFSSESRVDTSDTTLTEDNCVETSDPPPIPLSNKSILPSLVCNDSVSEVETRTEAEDNDKSLGESEVEEVIQGKSGQVSRPRPETNTYPTKRVLESPLKDSSTSSSEGELRVPQLQSTMRRSMPGQVMDNSELYELSRIDKNGTVISNDTPNQASNRGEETTLHQKSSCWDNYMEQHPESSYLREQEIEETDEEEWDIQNASSWIPPRKAKSLSPSPSKPDDAIPEEFIKSKQDRSVPSSTLREWMLEYAESKASPIRMKCPLKATKVSSTAWNEETMHTTNWHNLSTIEQEDSEEETEDESQPVKDKRLEKVAEQIVAKEGKLCVDNKTVSEESGIRGEDVIKEVPDLQSTETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG95</accession>
    <name>A0A232EG95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004807">
        <property type="protein sequence ID" value="OXU17385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG95"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8513" checksum="D402AEC28CBD7759" modified="2017-10-25" version="1">MLHIKKKSIFVKESVLTYLYTDVLRKLCKYTQQKEQEKSATKENLIKTLSGYKSKKIHATLRLDDIRKKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGU6</accession>
    <name>A0A232EGU6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004672">
        <property type="protein sequence ID" value="OXU17576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGU6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU17576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="353" mass="41367" checksum="05BD3229A95B98D4" modified="2017-10-25" version="1">MLDSSEVFSNKYFILNKKLLILIFIWPYQKKHLGIFVNTFIILAIHTMMIPQIIRAVLEWQMEVKNVEILIENFGGLLYFQGTLSKYYSSIYLQKKLQQLFEQITYDWKGMHDDNEKAVLLRSWNIGRNLTIFYMTYMFFACIAFVTLPSVVPLMLDLLLPLNESRQLKLCYFAEYFIDQQKYFVYLFMHTFFGVSFTILIVTAVDSTFVSIVHHALGLYKVLEYRMKNVLHLIENNYQFNSLLAKDELHKYIVDSVKIHKKTIEFSEIVQRIYSDCFFFVTILVLLFLSIVTIQLVMNLNNPPDFMRIGFMMMRCAVPCKLTAGPLLTMDLATSGNILRTAMSYFTVVASFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH99</accession>
    <name>A0A232EH99_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TTF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004564">
        <property type="protein sequence ID" value="OXU17711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH99"/>
    <dbReference type="STRING" id="543379.A0A232EH99"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="22218" checksum="43E3A3F551418CB6" modified="2017-10-25" version="1">MSDSRKRLSGCDYRKWAREKNEKMELICDLRETEENSQEIEKQSSCEYDADNANHTYSLSTNNFSDTNIDNIVTANISKSDLSISDDPFFWENNNYLHNGEKISGHWLIYSEITESVYCGPCLAFNGGTQFGSKNGFDDWKNIKRIEQHENSKTHKNCLLSLKARAEMKRASIISKTKQWVFQKRMIIHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHA2</accession>
    <name>A0A232EHA2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004538">
        <property type="protein sequence ID" value="OXU17736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHA2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11217" checksum="EB8C3D1302134A91" modified="2017-10-25" version="1">MKVRNSAETTINIHRRRNKQRIAKAIEEEMPLEANDTPILQTTLTEEKMTQKLANTMTDEISIEILENAVNEIDSNQLPAEITDEIWNEIDELLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI99</accession>
    <name>A0A232EI99_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004292">
        <property type="protein sequence ID" value="OXU18097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI99"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="148" mass="16341" checksum="683FD4AFC5183770" modified="2017-10-25" version="1">MAVWRERCHYIEDANAKIPKTTKYRLNINAGENDITSDDDTDGELDEHWRELIQRNDVTDSEISDSTISSNEEMSNTTSRSNEDDQQSLLYGSGINQPLSDAEQGRLQSPNVSSASAETERANGVNNNNNINTNHLSQTLSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIV1</accession>
    <name>A0A232EIV1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004150">
        <property type="protein sequence ID" value="OXU18290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIV1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="164" mass="18588" checksum="F011840289DF6BD4" modified="2017-10-25" version="1">MTGETDLKIEIQGAIFDLNARVSSVGAFLQEKYLFFQRIRPNETEANKVNTLVNLIKPSLRKTLRPVALVDFADLLSGSLQAERDEGEEMQYKPKISKPVSNDNRPAPQSSDKKTILPQCWHYPERHFHKDCAVYQAKRGSQSENWRKAADKPATDATDSIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIW1</accession>
    <name>A0A232EIW1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004168">
        <property type="protein sequence ID" value="OXU18251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIW1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="162" mass="17514" checksum="195AD88D774C8FD4" modified="2017-10-25" version="1">MTNTMISGTTSTTGVTTPTATTGVTTPTATTVATEAAVNTSITQTLMELVLITPSLISHLTWSVPFSALTLIRAQKFFRRSFPLASKCKLGFRAPVLIPNEPELWFTQFEQNLANAGITTETTKFSYLAKIQHKIMEQLRTAQPAGQFQIAAAEPAPNPAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ88</accession>
    <name>A0A232EJ88_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004060">
        <property type="protein sequence ID" value="OXU18426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ88"/>
    <dbReference type="OrthoDB" id="7697589at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="14441" checksum="807CFCC5656D4D66" modified="2017-10-25" version="1" fragment="single">IGIHAEADKIGYIQPNVLLLQNNPGLLSEKIAYMSPSNIDWKIIQKINLESYFETGNRLLIQCRTIQSLCDKTSSVCQHNQIQETNLQSEKIVELLAGLDLSKASRQSRSVLPFIGQMSRFLFGTMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJT0</accession>
    <name>A0A232EJT0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_005532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003942">
        <property type="protein sequence ID" value="OXU18613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJT0"/>
    <dbReference type="STRING" id="543379.A0A232EJT0"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF99">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU18613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="531" mass="56919" checksum="C78AAF4B8F5EEFEA" modified="2017-10-25" version="1">MTAEDEAEKKLPSRVKAMGGLVSATHSLVAQNITLSRTPQLEIWLRENLLLVLTVLGVLLGCLLGFLGRLGDFSAQTIMLVSFPGEILMRTLKMFILPLVISSLIAGMAQLDARSSGRIGVRALTYYMATTVLAALVGIAVVLLIHPGDPSIKNIVAQGAGDEAKVSTLDAILDIIRNMVPENLVQACFQQVQTTYVKKRLVLIGESPSHRSGYVLEPALVYRDGTNVMGMIVFCISFGLLAGHVGPRGKLMVDFFVALNEIVMKYSPFGIMCIIAGKIMSISNLAATAQMLGLYMLTVVLGLLVHGVVTLPLIYWLITRRNPAVFFRGIMQAWITAAGTASSAVTLPITFRCLEENNKIDPRVTRFVVSVGATVNMDGTALYEAVAAIFIAQMNGISLGLGEVITVSLTATLASIGAASIPSAALITMLLVLTALGLPTSDVSLLFAVDWFLDRIRTSVNVLGDGFGAGIVYHLSKDELDQMDGLKKLGPLETVVVPVLEQTSNDTLDFEKKDADNYIAGITESTSETKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJV2</accession>
    <name>A0A232EJV2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003944">
        <property type="protein sequence ID" value="OXU18608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJV2"/>
    <dbReference type="STRING" id="543379.A0A232EJV2"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002580">
        <property type="entry name" value="Beta transducin Trp-Asp domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="574"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="616"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="783"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="924" mass="103028" checksum="EB28DC1F7CA40E2E" modified="2017-10-25" version="1">MGLTKQYLRYVPGGNLNLIADNNCNIVFVTLEGQEGRFVAVGACEHVYIWDLRLGEKVQVLSGEKANVTCLAASPNKRQIAAGYDDGSVKTFDLRSAENVSVFVGHHSEVTSLAYDHLGHRLVSGSKDTDIIVWDVVAENGICRLVGHKGVITKVAFMRDHNIVISSSKDTFIKFWDLDNEHNFKTLIGHRSEVWGFTLVKDDEYLVSGCNDRELHIWKIYFTDALKSDSNIELPNLAIEDDGDEADMKYPLRCVKIGNIVRVGKGRINSLTADYSGQIVGCHGTDNTVELFHFLPEDQIKSKKSKRLDKLKKKAASDEKMKEKLQEAELDTILRDQINRLSVIKVCAKAKALDLIMGRGDELRICTNVSNNTIELHSLAVTEKTAEPQLLRTLSSHGHRTEVRAVCFSSDNLAFATVSGDSVKLWNRPTLTCLRTVECGYALSLTFVPGDRHLIVGLKSGKMLIIDIAAGDILEEIPAHENELWSVTLLPTLKGVVSGGGDKTVKFWQFELVEDPESESKAKVLSVIHYKTLKLEESVLCVRISPNNRFVAVALLDSTVKIFFLDTFKFFVSLYGHKLPVLCMDISSDSTLIATGSADRNIKIWGLDFGDCHKSLFAHDDSVTGIAFVPKTHYLFTCGKDGKVKEWDADNFQKIVTLQGHTGQAYNCAVSPNGVYAASCGSDKVIRIYERSSEILVLEDEAEEEREKQENELVTGETTAVQGQKNQILPTRKTVNSEKAAELILECLDICKAYKEECSTVVPPNPMPPLPLLMQAYKCNTVEEFLLETVKRVRASDFDEALFLLPYSAACEILRMLPSLLKSQYQAEIVAKLTLSLIQAHHGPIVASQELLPQIEEIKSLALQQVSSLRDTLGFNLYGMAYMQRAIEEKEGIQLFKEATKTQKKRNSKRKNKEKALKRAIMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK14</accession>
    <name>A0A232EK14_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003902">
        <property type="protein sequence ID" value="OXU18685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK14"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7222" checksum="393AD37551D9C5B9" modified="2017-10-25" version="1">MLTRRYIRVLRPRKPPSKKSRQNILLIFRGTLGDDVDTGFPGHQVPKGALPSRYSCSATLKTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKA4</accession>
    <name>A0A232EKA4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003822">
        <property type="protein sequence ID" value="OXU18796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKA4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="127" mass="13852" checksum="519FCBEDB67EF684" modified="2017-10-25" version="1">MARHGGELALHSSPVMPLTQASINNHNNSSASGASSPVTSPLSPTDSSRIPRPSPTALRRSSSLRLRGERSSYLHSQNLHRSQQHQDLFPVITENGTPTRCSSVRNIFSRSLCQSLDFVNPVARKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL04</accession>
    <name>A0A232EL04_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003662">
        <property type="protein sequence ID" value="OXU19043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL04"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11218" checksum="59C02A8D4745126E" modified="2017-10-25" version="1">MDNNKMNQNYHPQNNYQGTIVTTIMSSNNVIIGRLGLAMETEEISKYSIMTTRGLSGEERPGDRSLPTSPRPISLCGEDSSQWFRREERREPRERQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELD1</accession>
    <name>A0A232ELD1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003580">
        <property type="protein sequence ID" value="OXU19155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELD1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012737253" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20131" checksum="2ABF761AB302DB6C" modified="2017-10-25" version="1">MALKICFIAILVLFSLQKLMCQASILNPYFEDISFDFVNYSYVDSETFDVSINYKPKSRNSINVKIDLIEELPADMMASIIIIKFNVSSRVFGQEIPTGLSFESSICDNGNAKFFYDILMVPFGVKECPPEKGSYKKEDFIPDLSKVPIPLVPGTSLLIKIHMYAEGIQLLDCKAFIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EME3</accession>
    <name>A0A232EME3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003373">
        <property type="protein sequence ID" value="OXU19529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EME3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11508" checksum="93E6786F88A547D0" modified="2017-10-25" version="1">MTRMNDYWNVCNAAEVVDYYVNHHAGPKPGKMQRGVVNVLNLINRWINTNKVLILKTQQMSNKNTVTLSEATAKSAQIDSDKDRQRRINNLRGRGRGGKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMQ8</accession>
    <name>A0A232EMQ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7. The THO subcomplex interacts with DDX39B to form the THO-DDX39B complex which multimerizes into a 28-subunit tetrameric assembly. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC3, THOC5, THOC7 and DDX39B. TREX seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with POLDIP3 and ZC3H11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003316">
        <property type="protein sequence ID" value="OXU19640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EMQ8"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="401"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="9">
        <location>
            <begin position="545"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="8">
        <location>
            <begin position="918"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1239"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1501"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="941"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1246"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1271"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1299"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1374"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1431"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1501"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU19640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1524" mass="175293" checksum="39590E082F3CD8A8" modified="2017-10-25" version="1">MPAKTWNAELWKTWDKQGKAEFLKLIKLKHKEGNAAEWRRGLYELILNGIHGAVKRDGVVTTLGELVAIDGAIPSAVVDLFTLIDAEVQGENRSNFYYIVKESEKFLTDRILKERLDIDTLQDVGTLKNLNFQTKFIKVKTKLYYKQKKFNLFREESEGYSKLIVELNQERSESEVESVLEIVKSLIGYFNLDPNRVLDILLETFENRPQDAAVFIPLIRSYMSDQEVLCEVLGFKYCCTTNSTPFSLQKVTALMLQHEVINLDDILSWLVPDDKIIIRDYDNDMKQAKEYVRKMSVISTKDKEEEKDEKEPIVDKYCNNQKFGLCEALLEVGAWDVALNLFNKFPDYSLTDQKPIALALCKMIHALIEPVYRKHCIISAKLPGRKVPPLQSPLAPKPLTRLEDIHDHLLPMLVALGPNLHHDPVLMYKIMRLCHVAIKQCTLDANKLPVAKDNALYCDVLTILDVALLPSLSFMDCNCCVAEEIWNILKCYPYQNRYALYARWKNDTPLQHASLLRKRADAQKKIKNVIKRVSKETIKPVGRSIGKLTHSSPGVLFDYVIVQIQLYDNLIGPVVDSLKYLTNISYDVLGYCLIEALAGAERNRFKHDGTSISLWLQSLASFCGAIFKKYNIELTGLLQYVANMLKAQKRASCISDRNPMRIGKCRLFLLRKIFRLVLAAYDANLRAGEAVKEIARGKMTIRVRNLVSPMDIVCFLDLLILKEIVQKMAGIEAAEELTSDQLDAMAGGDLLRIEAGYFSQVRNTKKSSQRLKEALAEHDLAVALCLLMAQQKHCVVYRETEQSHLKLVGKLYDQCHDALVQFGTFLGSTMTVDEYIGRLPSIHSMLQDYHIHADVAFFLARPMFAHAIYIKYDTLRKADPNYKKMPSTMKQAKYAEAAQAVMAPVAQSVRPLHPLKVWEDISPQFLVTFWSLSMYDLYVPADSYQREINKLKQLATQAADSKDLTASKGKKEQERYTTLIEKLQDEKKKQEEHVEKVQAYLKQEKDSWFLSRSAKSAKNETITQFLQLCLFPRCTFTTVDAMYCAKFVHTIHSLKTANFSTLLCYDRLFCDITYSVTSCTENEAHRYGRFLCAMLETVMRWHSEKAIFDKECSNYPGFVTKFRVSNQFSEANDMVGFENYRHVCHKWHYKITKAIVVCLDSKDYVQIRNSLIILIKILPHFPVLAKLSQILERKVEKVRDEERNKRQDLHVLATSYCGQLKAKAPQMIRESDFHHVGDKAAKASETAGSTESNVEKVSNGVSTKEVNNGDSRADKEITKDQREKRTTSSSQAYQQHSSESSEKSRKREESREASESREKYSKKDDYKDEELPADKKDRKYYKDEHYYSGSADNFDRDLSSVSNSSTSSGPMADGPDRETTKRRKVESNPKETSSRRTEATVEKKERSSAKAKMREEQKELRREKKLGRKRDRGDDIIIPAEQKRRKDDDRAKGTATHQNGDMPEHREKHHYSKVVTVHIVYRVKNLYNVCSVYFQEKSPYAKERTHEREGRETRDKQYPFNTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMU6</accession>
    <name>A0A232EMU6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003277">
        <property type="protein sequence ID" value="OXU19693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMU6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="31" mass="3259" checksum="40530F318561D0EA" modified="2017-10-25" version="1">MIVAARSTLLLGILMHSGSSPSLSKSFYSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPC5</accession>
    <name>A0A232EPC5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002982">
        <property type="protein sequence ID" value="OXU20182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPC5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12715" checksum="FA11482249CDE737" modified="2017-10-25" version="1">MGAPRLVTRGRSIRKTRYFVQTQDLFLSSRNIILRFANIPTEIGVRRSVSLLLLFTSLILHVYFTVTENQPKIPEKESFCNCIFCPTIASNQLNNNDTHDEFYIKFDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ18</accession>
    <name>A0A232EQ18_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G patch domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002836">
        <property type="protein sequence ID" value="OXU20465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ18"/>
    <dbReference type="STRING" id="543379.A0A232EQ18"/>
    <dbReference type="OrthoDB" id="10019757at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF9">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="431" mass="48914" checksum="776F32C23C3C687C" modified="2017-10-25" version="1">MSDFAKAQLLKYGWTEGKGLGKNENGIAEALRPKLKFDTSGVGHKDLEFEWWESVYDKALKNIVLDKKSDKVSIKVAKENAFNISSTKYGLEVSKKKHSLHYGKFLKTSTLQDGNLINDSSCQPTEEEPRDIQSVTKMSDEELFKVCGGRTAHKGARHGLTLNGKLARIAEQEKQLIAAGYLKSKVESSDKNETKLKRKKKKKRDIEMEHSIFAVQNEIIAEANDDCVVLSTTKSDSDYKPSKKTCKKVKRKIHNLSQQLTKSCMIEDDAMKSEQETTEEKEPRKKCKSKKKKSKRKRDQEIAGNVINDIQLNNDTSMEPSTKKFKKHKSLLELSTSIVVDNNPSLNCVPNGDQIEPVKMHSKCKKEKGHHRSKDHKFSYCTKTEALRLNHKIKLKKSKTLKRKEKKTYGKLVESLLAVSLDADPSEESNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQX2</accession>
    <name>A0A232EQX2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002691">
        <property type="protein sequence ID" value="OXU20764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQX2"/>
    <dbReference type="STRING" id="543379.A0A232EQX2"/>
    <dbReference type="OrthoDB" id="7676095at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="157" mass="16695" checksum="9BEE166648A03662" modified="2017-10-25" version="1">MGTIIVTPSSVGYQQQEVTRTVDLAKESSNAVSKVPSTSAIGAGKGGIVLRDTILLGDYEKKFAEFTKSWPKLSAFSGAFGDASSFFRGSSLNPSISSGLARSSDNIDTSNSIGRQGYAVKEEIDEPPFDFRSNPIIASPLHIYPTPAASAFFRHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER91</accession>
    <name>A0A232ER91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase Tc5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002662">
        <property type="protein sequence ID" value="OXU20842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER91"/>
    <dbReference type="STRING" id="543379.A0A232ER91"/>
    <dbReference type="OrthoDB" id="7548347at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007350">
        <property type="entry name" value="Transposase_Tc5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04236">
        <property type="entry name" value="Transp_Tc5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc5 C-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="12252" checksum="45611FA5F251ECF0" modified="2017-10-25" version="1">MNEELNFHLRNNIIKLQSLVHNQLSSPRYINLFKYSWYKSCYTDVHPKNFENPVNFAFRSQSNILCEIAGCSNVAIVRCSWCKKSLCLKHFFDDYHYCSTYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERF4</accession>
    <name>A0A232ERF4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002612">
        <property type="protein sequence ID" value="OXU20938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERF4"/>
    <dbReference type="OrthoDB" id="7692318at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20205" checksum="7772075060668ACD" modified="2017-10-25" version="1">MSKSGKVFCSFCTDAITNKFPLVENRSCQISKEAFVTVGFNCWKNAAQTFKNHESSELHTAATKFESNEKEKLEARIVLRAIFTTASYLARPGLSFRRENDKESNFYKLLELRSHDIPQLKAWLNRKKYENSWLHHTIINEILSMMADEIKEYICKLVVYQAWLCHLLTCGQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERM7</accession>
    <name>A0A232ERM7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002575">
        <property type="protein sequence ID" value="OXU21015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERM7"/>
    <dbReference type="STRING" id="543379.A0A232ERM7"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="262" mass="29329" checksum="57909D047FA22F39" modified="2017-10-25" version="1">MSFFNKADYFSPTPFWQNGPAPGAIYNFPGPTSSSGTNGMQRTQSPMTTGTSVIGLQFKDGIVIAADVLASYGSLARFRNCERVIKVNDNIILGAGGDYADYQYLRSIIEQKILDERCLDDGFTLKPKSLHCWLTRVMYNKRSKFDPLWNNFIIGGIEDDKLFLGTVDKLGTAFTDPVIATGYGAYMASPLLNKAYEANPEMTEQEATDLIYKAMQVLFYRDARSFPKYHLGVITKEKGVEIKGPITIDHNWEVSTMGRDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERW4</accession>
    <name>A0A232ERW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002548">
        <property type="protein sequence ID" value="OXU21082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="380" mass="45125" checksum="1D9810231B596225" modified="2017-10-25" version="1">MEEFEPVKKEREFYKQCMRYGDEQAALTRGHLRFLGIMYDNLSSKWEIIDRHLYRGGFGYAFFNIRIISDPRYRDQNIILLEPPTFDHFTEVYETLKVVKLFSKKFKEPKKDIEFLLHYYVDSDRPKHVQRLIESVIQAIFESTTHFVDNGSKVTTINNWRSDFNKRYERSNVTDWEYKLSGNTALLVKNEMYFSKLFDILFETPNEVIITSIVMKAIAENLKYINWNLATKIKVMSSRHRSEFCLHSTKLYGISYGILKEFDYDVKESYLGNILQFRKIMKQKELANLKPELGESDEVNLPFSIIDLARPANRFAINVYFPSLKFNHKLKIQYLEAMSNTYGLRIVHKALQPSINSVRLFPENGLNHMRQFFHLEYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESB6</accession>
    <name>A0A232ESB6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_000688</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SH3RF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01002453">
        <property type="protein sequence ID" value="OXU21241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESB6"/>
    <dbReference type="STRING" id="543379.A0A232ESB6"/>
    <dbReference type="OrthoDB" id="2163411at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16750">
        <property type="entry name" value="RING-HC_SH3RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11786">
        <property type="entry name" value="SH3_SH3RF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11787">
        <property type="entry name" value="SH3_SH3RF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11783">
        <property type="entry name" value="SH3_SH3RF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11785">
        <property type="entry name" value="SH3_SH3RF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000077">
        <property type="entry name" value="E3 ubiquitin-protein ligase SH3RF1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000001">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035816">
        <property type="entry name" value="SH3RF1/SH3RF3_SH3_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028502">
        <property type="entry name" value="SH3RF3_RING-HC_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF51">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="490"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="891"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="287"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="427"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="559"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="333"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU21241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="950" mass="101675" checksum="B2BB6BC0B27A91BC" modified="2017-10-25" version="1">MAHPGQGLACDNTTTAMDECMLNDLLECSVCLERLDTSSKVLPCQHTFCKKCLEEIVSTHRELRCPECRVLVSAKVDDLPPNVLLMRILEGMRNATPKGNKTPQRHHAPQRLLGGHQVTPSSPSITLNPPVAIVTPESAHQINVAAKQVHLHNRPYGRAIYDYISKVPGDLSFRKGDIIILRKKIDNNWYHGECGSNHGVFPLSYVQVMTPLPPHVPQCKALYDFRMSNDEEDGCLTFNKGEVISVIRRVDENWAEGKLLDRIGIFPLAFVELNSVARALMKLSTNVQPGPSRVAPPTPTNEETTPLIPTDHTRTVQASNQPRQQAAVNPALPVSDSSSNVSSGGSSTTTSSPVITSPSSSSSSTTPSSPSSPAISPPTVANRHSTKRHSFTAVNSAHQPQPQHRHSAEILSLAVDAALAGAEAATNDPAFTSSQTSGSAGDQNPRHKRSGSSDLVLSQASSMTNSAPAGSSSASSSGATAAAASGVGSNLPAAYIALYPYKPQKADELELRKGGIYMVTERCQDGWFKGTSNRTQKCGVFPGNYVAPAKCQRGVCRSPSTVPLQNSASGTSSSASNIVPSSQPSNASSEPRIPVTYTKVKGAAPQPYKLPPPELPPRALSPGPAGSSAAWHSPRQQPNQTQSPPRLPDQTVPVAAASIGRSHSAVMPSIFTSPGKLPLVTTTAATASSLATTTSVSDASKSPINTAHAATASASASSSTATPKSTEKVKEKKEKGVSLMRRLTNIKKSKSPPPSTYSMDNPVFDDGNAGQSLSINPIHVRDLPINATELVQNDKITRSCPSQLLQVGSPQDVNASTNSHHRMYPSQGHVTTSQRVKHKERPSLPVTFLQRSGESGGIITGTMSNHHRKSNSLDAGTGKQVKQQLSSRDRERMYRFRCIVPYPPNSEFELELRVGDIIYVHKKRDDGWYKGTQQRTGRTGLFPASFVEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESQ9</accession>
    <name>A0A232ESQ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_001121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002381">
        <property type="protein sequence ID" value="OXU21403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESQ9"/>
    <dbReference type="STRING" id="543379.A0A232ESQ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="342" mass="38652" checksum="A9EBDFA6E57A5FD3" modified="2017-10-25" version="1">MPKKCCLPNCKVQRDDPEGLDLSFYIIPADENLRKKWSENIKQHYNVEFKKYSYVCSRHFEKHCFEPSFSTKMNRKLKKGSCPTIFVDFKSLKQKDTQDKENVIDNKNCNDFVSHSLSNGSINTAVGSNVIDVSTHNEEVDVLECDSDNRDTDTISSITISNLISSHEVLLAESETPESTSMSVANNVQENTDNSSSNLCSSQISLQLSSSEETPLPDIESSCFIDPNVQKSKDSSISEVTTSKVTTITSTSIHKKSLSNIDVDSIPFTMENLPIIRRILLNGKNEVIALKRKLQARRMKVYRYKKRVTDVKSLSSHMKDQKFLTDKVSKLLEVSINVNKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESR5</accession>
    <name>A0A232ESR5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002381">
        <property type="protein sequence ID" value="OXU21395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESR5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="365" mass="42541" checksum="FCAE77333583D31A" modified="2017-10-25" version="1">MISQKSADLNSSQKNSQANSTVKYALVNYLKDNVSKIVPIEYIALDRNQTKFKPLDCFDFDVKQKYYVQWFYCTKDGINCDNAECNHEYDIYSAFIKYLGETKEMIERQSQGKRLPVVNKKYVSTTESDDENDAAEINEVKEFKKEKSENKNSCSPTTPEKQTEKFSLASRNCRKRLFDNNESCDKTMASQPHDDRWTRAFENLFDKSQSESSSRDKTDINKSSQRHTNEDSNMNNHKAPSENISTIEENVMPAAKNADNVMDMAREFVENIYSDNENDIDNENQDHGDQQLDLDQGDQQENNQDNQQENHQDHEQENHQNDQQMPDTDGEVLRVKKFVLECILYYENARDGHALEEKQKRYTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET08</accession>
    <name>A0A232ET08_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002364">
        <property type="protein sequence ID" value="OXU21457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET08"/>
    <dbReference type="STRING" id="543379.A0A232ET08"/>
    <dbReference type="OrthoDB" id="6779810at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="285" mass="32432" checksum="483A6DE626A14808" modified="2017-10-25" version="1">MVADNSLPEKPSIDHSLGENVSKIISNFDVSQSSSSSSDESSKSRLDNDSREDKSYDTSAKDESNDENRQLNNTYLCYKSDCQGDFVENAALEKEEEAKDLITSIISKRSSPAKSTPRKRRNVFSLTSDFDECDWNSELGSKIETLTVDESRLADHENDESLIVRIRNYLAEYQELRGTSREEYTFSTLIKVMGQATGRCLFALFYVFLKIAPVLEVFLHILRFVLDKVIDIKSTTDVQQIIVKNAIFVFQLASIYVCLIFIFGFIISPFIRMAFGMLSKIMLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU41</accession>
    <name>A0A232EU41_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002196">
        <property type="protein sequence ID" value="OXU21837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU41"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="8445" checksum="23D6702FB5746659" modified="2017-10-25" version="1">MSEMQGTRSEIYQQISDKRMNHCYNCYIKGKKRKQEYLRRVTYHFNTRANNTKTCSGCGQRTLPKRKKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUQ7</accession>
    <name>A0A232EUQ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002106">
        <property type="protein sequence ID" value="OXU22066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUQ7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="224" mass="26182" checksum="A9EC5DD3A2EF3558" modified="2017-10-25" version="1">MIAMQKIDRHFDAMHHLLQMFDKYKNWPKNSLQNILLELAFVYFKKDRNLEESLKYFLEAIEINRDAKSLKHDKQFTNVKDTLPKSELAFKSSDVLSLVLRQPKKFVFNKRTCETAEKLRLLSQSEEKNAVKSNMPKSFWRTELSSVENTLYALDKDNSRMDPMLRFNAVYEKINAEVHGSADFHEDVDKCSTARLMMLDSDVDINNRFTNDGESETLLLESGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV23</accession>
    <name>A0A232EV23_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B-cell CLL/lymphoma 7 protein family member B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCL7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002061">
        <property type="protein sequence ID" value="OXU22201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV23"/>
    <dbReference type="STRING" id="543379.A0A232EV23"/>
    <dbReference type="OrthoDB" id="5989898at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006804">
        <property type="entry name" value="BCL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767">
        <property type="entry name" value="BCL7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12767:SF9">
        <property type="entry name" value="BCL7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04714">
        <property type="entry name" value="BCL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14716" checksum="90B8CFC7B4137B89" modified="2017-10-25" version="1">MMSRSVRAETRSRAKDDIKRVMQVVDKVRHWEKKWVTIGETTMKIYKWVPISTLDQKKKVKSSAVEKENGLARKGGIDSSNSNFGLTEDSNTCFSTVSDSQGLTDFSAHLGFSEDSNSQNSEPAPKRLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV53</accession>
    <name>A0A232EV53_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002055">
        <property type="protein sequence ID" value="OXU22223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV53"/>
    <dbReference type="STRING" id="543379.A0A232EV53"/>
    <dbReference type="OrthoDB" id="6340174at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF22">
        <property type="entry name" value="IP12060P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012782477" evidence="1">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="21174" checksum="3EA6BF203A345E7F" modified="2017-10-25" version="1">MHLLLAAVLLLSLLGEKVQSGARNSEMASILHRPIRAISYPSNSNMGIFVAIAVPLEDPVNSVSLSYFFEASYGLPDNSSYYLLPAGIERSRRKRGIDRATVYALLQSRLQSSAGFPGHECLLRSICEASEYPLEHNGLLGDVFRVVFTPSSSRPEDHLPDGIVEAELKGRNATCQDYHAGCPIGLFDLIGVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVD8</accession>
    <name>A0A232EVD8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Putative alpha-L-fucosidase</fullName>
            <ecNumber evidence="5">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alpha-L-fucoside fucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_003392</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose</text>
            <dbReference type="Rhea" id="RHEA:49308"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:91119"/>
            <dbReference type="ChEBI" id="CHEBI:91121"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:49309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose</text>
            <dbReference type="Rhea" id="RHEA:48224"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17006"/>
            <dbReference type="ChEBI" id="CHEBI:28691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48225"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01002011">
        <property type="protein sequence ID" value="OXU22311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVD8"/>
    <dbReference type="STRING" id="543379.A0A232EVD8"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018526">
        <property type="entry name" value="Glyco_hydro_29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00385">
        <property type="entry name" value="ALPHA_L_FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016196799" description="Putative alpha-L-fucosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="14">
        <location>
            <begin position="46"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="15">
        <location>
            <begin position="390"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="site" description="May be important for catalysis" evidence="13">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU22311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="477" mass="55844" checksum="A12A4B696F5FA2D4" modified="2017-10-25" version="1">MIVYKAFVLLCFFVTCTLAAESPYYYLFSAIDEKDLGEGSTPVEITVKYDPTWDSLDKRPIPIWYDDVKFGIFIHWGVFSVPSFGSEWFWINWKTGSKSIRQFMKDNYKPGFTYQEFAKDFTAEFFNATEWSELFEASGAKYVVLTSKHHEGYTLWPSKYSFSWNSMDVGPHRDLVGELAEAIRRNTEIRFGLYHSLYEWFNPLYLEDKKNNFNTDNFVLNKIIPEMKELIKQYKPEILWSDGDWEATEAYWKSKEFLAWLYNESPVKDTVLTNDRWGVGTSCKHGDFYNCQDRYNPGILQNHKWENCMTIDKKSWGYRRNAPLEEYYSLEDLVKELVITVSTGGNFLMNVGPTKDGIIPVIFQERLRGIGKWLKINGEAIYKTKPWVLQNDTIQKDVWYTHGQNGDIFATLLSWPKTNNVHLSNLVKTTEKTQISILNIQEPLIWRQESDSLKISLPLEAHKGEPAWVIRITNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVQ7</accession>
    <name>A0A232EVQ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001962">
        <property type="protein sequence ID" value="OXU22438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVQ7"/>
    <dbReference type="STRING" id="543379.A0A232EVQ7"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00045213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58153" checksum="10B7966C49D4AD41" modified="2017-10-25" version="1" fragment="single">TASTNEHYRDFLRVKTMAPNLEVVVGTYEQFLLGYTVDDVVNKYKMEQSFATHSHLASIRSVASNKHYLASSAADDTVCLYDMRTRMENGKLVHHNDTVNSVAFTPDASHIITASSDGTIGIVRCGNWQVEKHWLKPHKGLAVDTLAVHPTGKIAMTTGHDGVLRTWNLVKGRQAYATNLVPRWKLDAKNISVLKWSPTGNSYLLAANNRIDVYSVETAGIKEEFNFDAKVVCVEYLNDEYIAIGLADGKIIIHNCETGDLTKEIQAHEARVKCLASEGDMLVSASSSGEIKLWSVKSNELKLLSSTNCSARISCLTLNSCEYLKKKQDEITVLDKVPEKPSNKLRLKQCVIIEEEGGDENKTTRMSKKKRDKKKARKLLEEAEQANAEDENVKTVQTKKMKTDLPKKQKRDTSDLPSENPKKKKKLDSPNKRKSTDSVDDDITEVPAKKKKQKGIATEKAIADKSNQINANKKKRKIPLEDTENSPKKQKAVVAKVHKGEHALLKKKKKKNFKNKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW39</accession>
    <name>A0A232EW39_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Suppressor of white apricot N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001922">
        <property type="protein sequence ID" value="OXU22557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW39"/>
    <dbReference type="STRING" id="543379.A0A232EW39"/>
    <dbReference type="OrthoDB" id="5836667at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF15">
        <property type="entry name" value="SPLICING FACTOR, SUPPRESSOR OF WHITE-APRICOT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="5">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU22557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="11553" checksum="6375FE5ECCFEBA1B" modified="2017-10-25" version="1">MLANAIVCSKSELEASAELQKYSSSQQASSSVCEKMASKGQRWVVDSGILRKKTGEEEPQELLVFGYSCKLFRDDEKAKLIDQGKHLIPWMGDSTLKIDRSVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWV1</accession>
    <name>A0A232EWV1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001817">
        <property type="protein sequence ID" value="OXU22832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWV1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="43" mass="4866" checksum="732798952642863D" modified="2017-10-25" version="1">MGNSAVFRDGLPLIGFIRVPVYIIEFSTIPLSRFGNQCKFTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX13</accession>
    <name>A0A232EX13_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_007106</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="NNAY01001802">
        <property type="protein sequence ID" value="OXU22880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX13"/>
    <dbReference type="STRING" id="543379.A0A232EX13"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="344"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="434" mass="49090" checksum="462345E6521553A1" modified="2017-10-25" version="1">MDFEYTHRKLSSLRKILERSGPFCRPDFEPSSEALKFLMHDCKILVIGAGGLGCECLKNLALMGFRQMHVIDMDTIDLSNLNRQFLFRHKDIGTSKSETAAKFINDRIPGSNVIPHFCRIQDKSEEFYRQFHLVICGLDSIIARRWINGMLTSLLVYENGILDQSSIIPFVDGGTEGFKGNVRVVIPGLTPCIECTLDLYPPQITYPLCTIANTPRLPEHCIEYVKIIQWPKENPFDCCIDGDDPQHISWIYEKSNERALNFGIRGLTYRLVQGVVKHIIPAVASTNAVIAAICCTEVFKLATSCSASLNNYMVFTDTDGIYTYTYKAEKNEQCLACSQISRELHLNSINLKLKDLIELLCSQNDLQMKNPGITANIFGKTKTLYIQSVPSIEEKTRQNLSKTLFDLGLRNESEIIVADETTPNTVVFKLKFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXL7</accession>
    <name>A0A232EXL7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATPase V1 complex subunit H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001730">
        <property type="protein sequence ID" value="OXU23101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXL7"/>
    <dbReference type="STRING" id="543379.A0A232EXL7"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00256">
        <property type="entry name" value="VATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="7">
        <location>
            <begin position="376"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="521" mass="59723" checksum="3FCAE1FC8CD47178" modified="2017-10-25" version="1">MADRTNIKDMIPALPDENIDMLAATSILQQQAADIRSQRINWQSYLQSQMISKEDYDFIVAFDTSDSAAREAKLKENPGQAAKTFLNLLGHVSKDQTIQYILTMIDDMLQEHRNRVEIFREHSTRKRESIWGPFLNLLNRQDGFIMNMTSRIIAKLACWSHDPMEKTDLQFYLTWLKDQLKLSFEALQEGSMHAEIAQDANPTETGETNELHELLNPVGSNNEYIQSVARCLQMMLRIDEYRFAFVSVDGISTLLSVLSGRVNFQVQYQLIFCLWVLTFNPLLAEKMNKFNVIPILADILSDSVKEKVTRIILAVFRNLIEKVEDSQVAKEHCIAMVQCKVLKQLSILSQRKFDDEDITDDIEFLNDKLQASVQDLSSFDEYATEVKSGRLEWSPVHKSGKFWRENSSRLNEKNYELLRILVHLLETSKDPLVLSVACFDVGEYVRHYPRGKHIIEQLGGKQRVMQLLSHDDPNVRYEALLAVQKLMVHNWEYLGKQLEKEQTGSTGASGAKAGTQVPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY67</accession>
    <name>A0A232EY67_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_017015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001671">
        <property type="protein sequence ID" value="OXU23265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY67"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="14001" checksum="FFE32E57099B9596" modified="2017-10-25" version="1">MIVIIALSKYRFCGSVRLPIILSSVISHATTILRLHNVVVSKEEIYIPRADLLIDRISPYSWRTDATLQFDYTFRTAIPRWSQLDLFGRYGQRFVEFKQVETMNNRDGKSIDTDPYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYZ9</accession>
    <name>A0A232EYZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001562">
        <property type="protein sequence ID" value="OXU23591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYZ9"/>
    <dbReference type="STRING" id="543379.A0A232EYZ9"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MENG-PO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="408" mass="46734" checksum="68FBBC11C4FA0E9D" modified="2017-10-25" version="1">MILVTASQDSLQRQASSGQSQKMKLNEKKESGIHKVQEVSLEELDLSKEYQVEKTLGEGSFAKVLLATHRRTQTRVVLKAVHQELTTERDFFREFHYAYHLSPHPNILCSYAVAFKAENCYVFAQEYAPYGDLAGNVRAGGLGEEICKKIASQLASALDFLHSKQLAHRDVKLENILVFAQDMSKIKLCDFGCTRREGSLVGKIRCTWASFLPPEILDIIKNERYNCKRSADCWQFGIVLFVCLTGNPPWQSADLIQDPDYSAFQRFLKRRTTKIPSNFRRFSPRMLRYFRRVFEHKPEKRPPVTEVNKYLKDVWCVSKLSHSATSTSVDENFVRQADSLLYLNTIVDDRNNFDENKNKLKKLLNSYGLETSVDQKDMTKRIWEWVMQCDSNVGDSGLLSTNLGGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ82</accession>
    <name>A0A232EZ82_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001513">
        <property type="protein sequence ID" value="OXU23742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ82"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="10908" checksum="FA4C5A3B74F3F748" modified="2017-10-25" version="1">MIPGDDVDTVYPGHQETTLMLPTLGTGYLEERCRRDIRVQRPQKPPSDKTRHYQVHGVFTCHLNTSSQVCAETPSRGDGTRAESAENSGKEWHKNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZQ2</accession>
    <name>A0A232EZQ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_016316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001485">
        <property type="protein sequence ID" value="OXU23809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZQ2"/>
    <dbReference type="STRING" id="543379.A0A232EZQ2"/>
    <dbReference type="OrthoDB" id="10049706at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15927">
        <property type="entry name" value="7tmA_Bombesin_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF26">
        <property type="entry name" value="NEUROPEPTIDE CCHAMIDE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="53"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="437" mass="49553" checksum="5B3B916C2278225A" modified="2017-10-25" version="1">MYNITWHLNGSTSTIFSLEEEDEEDQYIPYEERPETYIVPILFFLILVVGVAGNGVLVLTLLRHANMRNIPNTYVLSLALGDLLVIVTCVPFTSILYTIESWPWGLAVCKLSECAKDISIGVSVFTLTALSAERYYAIVNPIRRHVAGLSAKPLTILTVTLIWLLASILALPAALFSHIPTEPLKGNHSITICSPFPKEFAMILNPIHILLNTLTRTKIDCISAIFEYPAKTNRAFLHVKGESYEKGMVLFKFLAYYAIPLCIISGFYLGMARHLELSTRNMPGDQPGAPHHCEQIRARKKVGKMVIAFVIIFFVCFLPYHVFMLWFHFYPASREVFDEFWHAFRIIGFCLSFINSCVNPIALYFVSGTFRKRFNEYLCCCIPSVRRAANAQGRFPRTRGEASTFYETSFNSTYRRHTQELNSSTLLNYTAGESKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZR8</accession>
    <name>A0A232EZR8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001427">
        <property type="protein sequence ID" value="OXU24006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZR8"/>
    <dbReference type="STRING" id="543379.A0A232EZR8"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="106"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="387" mass="43112" checksum="3CC48CB49EB59756" modified="2017-10-25" version="1" fragment="single">TIDLYETNDKPGDKALYRRFLFDENNAVSKKLSDSFYLRNDMWKQLLFLVILTAAPIKRIDGNNHNIIPDVSSDATTVSAVNSDDTTIFTVNSTPEKPSRNLTGRIVNGTAAYLGQFPQQVSLRRRYSQAHFCGGNIITPEWILTAGHCMFAIKTGELLEPYTIIVVAGEVALKHTSFARQWSYVSKLIVHPEYDKETLRNDVALLKLLKPFKVDEYAAPAPLARIPMKPGTLCQVSGWGYQKFEEPIVSGKLLFIDVPLVETSLCEKLLENITEINEGQICAGYMEGQRDACGGDSGGGLICEGFLTGVVSNGYNCALPLIPGWYSDVRFYTPWISKHVDLTSNFDYRVGMVRDNSAAVETLSLSTFLLSTIAVIYTQFVFSRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0R6</accession>
    <name>A0A232F0R6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001354">
        <property type="protein sequence ID" value="OXU24264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0R6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="43" mass="4957" checksum="C16714099624C672" modified="2017-10-25" version="1">MQGMHRQPLNSKYRNILLYFLEKATPICIYLCCQLHGPNTSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0U7</accession>
    <name>A0A232F0U7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_007372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001341">
        <property type="protein sequence ID" value="OXU24304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0U7"/>
    <dbReference type="STRING" id="543379.A0A232F0U7"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26302" checksum="AE8250B7B4944711" modified="2017-10-25" version="1">MVVGVFPALKLGVLFIKQISKPLSKIIVNQAKNHPVFRTYFIIPPAQFYHWAEVKAKMYLMNLGKPTKVAKLNEQMAIELGASLMGEVIIFGVAGGCLVLEYNRQAAKEAKKEEIRLMQLQKFTDDIQALNNMTKKQEAEMEYLRQSLEELAKKTKTKLPEKKTEPSEKPPSEGDKQNVINRAITYYETEVKKKEKPITIPDLSLRSLVHKTCYNLSIIDNIQSVSDCMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1A0</accession>
    <name>A0A232F1A0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001268">
        <property type="protein sequence ID" value="OXU24556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1A0"/>
    <dbReference type="STRING" id="543379.A0A232F1A0"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="6">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="578" mass="64338" checksum="11ADCBDDEE32B453" modified="2017-10-25" version="1">MASLETGAAHQSGENTSWRKDLISQLRDRNRTQTQCFYDLISLHNRLFDNANTLRGENLQLSIANEKLRCEVSSGIPGSGANAALEAKLLAQADELTMLHRRRGEHTQQIVDLNNKLQEVMKELQAKEASLAENLEVNIGLRSEISRYVTKERELENINQMLKDEHQALQLAFASLEDKLRKAQEENRQLVDRLIKYKAKDAEKMNEENDNFLNESFTSPTAFLMHTISKFGKRQVKMQKELEDAAKDTRPASPDRVSLKEGLLGLPTSVPTKVSIKFNAHEGEVNAVRWSPTDRILATGGADRRVKLWDITKGGYECKGILVGSNAGVMSVDFDSSGQHILAASNDFASRVWTVGDLRLRHTLTGHCAKVMAAKFLGEPSKVVTGSHDRTLKIWDLRSRACVETKFTGSSCNDLVTSDGSGSTIISGHFDKTIRFWDTRTESGSNDIVLQGKITSLDLSRDANYLLSCVRDDTLKLLDLRMKMIVASFSADGFKVGCDWTRATFSPDGQYAAVGSSDGSIFIWSVTTNKIETVLKDHTTAVNFFHRDAVTAVSWFPHGTYLASVDKAKWATIWGDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1I5</accession>
    <name>A0A232F1I5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001348">
        <property type="protein sequence ID" value="OXU24287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1I5"/>
    <dbReference type="STRING" id="543379.A0A232F1I5"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU24287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="309" mass="34065" checksum="18F2B309A6A0A3A8" modified="2017-10-25" version="1">MRMGSCVVFSAAGFLLVSLSNTRWLAITGVVVTSLSSGLGEVTLLSYSHRYTKNVISTWSSGTGGAGVIGAASYMGLRYFFTAADSLLLMLVVPIVQALTFWLILTHPEPNIALVVESGGIGSQEQIIEAPKMSVGEKLKLVPGLMKYMIPLGLVYLFEYFINQGLYELIQFDNTFIGHADQYRWLQTDYQIGVFLSRSSVNFISINKIWLMSVLQLANVVLLTFEAVYWYIPNIWIVFALVLWEGLLGGAAYVNTFYRMSKEVPWEQREVSMGIASMADSIGIALAGWASMPVHNAICKLPSPTRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1N6</accession>
    <name>A0A232F1N6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_007333</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001242">
        <property type="protein sequence ID" value="OXU24631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1N6"/>
    <dbReference type="STRING" id="543379.A0A232F1N6"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU24631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="401" mass="44590" checksum="553AFBA6C88D7A7A" modified="2017-10-25" version="1">MSSQICLKWNSFLNNIASSFESLWQEEGLVDVTLASDGQCLTAHKVILSASSPFFKKLFQTNPCQHPVIILQDVHFTELEALLVFIYKGEVNIEQKNLPALLKAAETLKIRGLSGGDIFPKESFKRLAELEQEVLDEAELLQEEVQPKKKQKVHKNSSLLEKALAPKLTQTEIKNNNSATSSTSSNTATTTTTTTATTVSNEVSCEATLSDALPNPIYHGLEMKVEPFEVSVEDLQSHSPIDKDALVQLDTGQEDECQGSGNTAAEEISTLSGLSGLTGLSDVKPLLYSYQQLPYADLLPSPEVISTWASSRPIDHLACDLMKILFTPEERILCNVNGKMGKQQFDSNKIHLIREVLLHFSGITPNSIEWEEAWKNCVTKIDTSNRGLKRYLFQRRSIYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1S6</accession>
    <name>A0A232F1S6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01001298">
        <property type="protein sequence ID" value="OXU24439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1S6"/>
    <dbReference type="STRING" id="543379.A0A232F1S6"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000018">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008742" description="E2 ubiquitin-conjugating enzyme" evidence="9">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="10"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="173" mass="20282" checksum="DAC35F29BB1F894D" modified="2017-10-25" version="1">MREWFLIFYLIIILLILRVTELNKNPVEGFSAGLIDDNDIYRWEVLIIGPPDTLYEGGFFKAHLQFPKEYPLRPPRMKFITEIWHPNIEKNGDVCISILHEPGDDKWGYEKASERWLPVHTVETILISVISMLADPNDESPANVDAAKEWRESYTEFKRKVARCVRKSQEECM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F313</accession>
    <name>A0A232F313_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_008928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FCHO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001095">
        <property type="protein sequence ID" value="OXU25144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F313"/>
    <dbReference type="STRING" id="543379.A0A232F313"/>
    <dbReference type="OrthoDB" id="5593455at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09265">
        <property type="entry name" value="AP_Syp1_like_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07648">
        <property type="entry name" value="F-BAR_FCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000016">
        <property type="entry name" value="FCH domain only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF15">
        <property type="entry name" value="AT02057P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="4 7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="701"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="280"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="569"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="108933" checksum="67E11050E1C7A4BC" modified="2017-10-25" version="1">MTVDFADYFWGEKNNGFDVLYHNMKHGVVASKELADFLRERSVIEENNYKLLSKVAKQASNSNSTQGTFAPLWAALRGAAEKLAGLHLQLAQRVTELIKDVAKYSDELHKKHKAVKEEESSTLEVVQSIQSITITLQKTKDTCLQRGLELEKLRKDNASQRELEKAEIKFKKAQDDYKNLVDKYTAIRNDFETKMTQSCRRFQDVEETHLRSMKEFLNTYADVLQSNHEQVGQVHIDFKRQCLDMTVDKLLEQFVQSKYTGFEKPGVIEYEEVLTSLAEMTSQTGQEKNSEAPKEISKGANGETGVAGNSQALKKIQGGKREGFYTTGRDKSKLHDKEKEKPSERENECVQAQQTKASRRTTSLLNLFMSNSQERQRQAGSGSAPVSPQENLSPAVPTPSISRNPLRGSKWFLRSRREKRKEKKAKKKKDSVETASNKEDKSDPEDKDQDSRKSGTPTPEVDEDGFCIKPKTDPWENEKGFYSSSDTDSDDERERKIRVEIKPLSNGGAPMSASVDELRATVENLSLSPAPTGRRGSSTDSDHHMKRSQSVSQQLGVKPSSDLLNLFNPSSTPSSASTPTGSHPYAPLQSPPGLSSSPIPTMPPPPQSAPPLPRFPEGDLFSELNDVTPALPPKQSATPTGSSIAIPRPPSRRGDAITRGRMSPATISRADSVASLEFRTAGVGVGSSRGPSPLTIGLADTIPLAVAFHEIIHSYFRGSDEARCQVKLCGDMMLSFPAGIVAVFATNPNPAKLTFRLKNSNRLERLVPNNTLISMDATQATADSTLFEFNMSALTALLRRQAEQNPAASYFNVDILKYQIKNKEGAGSCPFQIVAYWKCNPTHTDLKVDYKYNSRAMASPTPLLNVQVSVPIDGGFKTVQSKPNAQWLPDTNRLLWKFTELSQHTEGAGVGSLRARVELSRGPGNQGTIFTQFNCEGTTLSGVEFELGGPGYRVSLTKKRFASGKYLCDGDVDVRTRYAAPPSNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F373</accession>
    <name>A0A232F373_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001153">
        <property type="protein sequence ID" value="OXU24969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F373"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11596" checksum="F30EE99F79AFA207" modified="2017-10-25" version="1">MSVRSSSTPRASSGHCSLTAKLVRDAVKELEKRRQRVPLSLLLTHFQQRLPVQRNVELLKHEILEQATKAVKLGYLRQFADGSYCLSTLRWQATVEEFGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F452</accession>
    <name>A0A232F452_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001075">
        <property type="protein sequence ID" value="OXU25233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F452"/>
    <dbReference type="STRING" id="543379.A0A232F452"/>
    <dbReference type="OrthoDB" id="10042249at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="693" mass="78056" checksum="C8DF19CEED8FB4B8" modified="2017-10-25" version="1" fragment="single">TYTVAMTDPQLVNNNNQNNRTETSNNYNNNNHDNKNHNHYDGEPKYRHKKFKKMATSGHVIDGVISDTKTLGINADTFNSVIETRKLGYICPYCKISCAKPSVLQKHIRAHTNERPYPCVPCGFAFKTKSNLYKHCRSRAHTLKMEGPDTSKIMQTSSQLSEDSDVSLSDGTSNGTNTPPPMQYMPLLSYNSSTGMSFNSKITSSSKKYDKIYKPKFHTVLRDDFTIEKSRSDFSNDERLHGHIESIIDDNATIVKAVDPKLRKLLHRQNSLAELVDHEPEYSRKRCFSECVITDFNSEQISDCKVVSEPEKSPGPLLGNTKLIEVIKQPRLEHELSQTVRPNSLQMFGGEVKILDTKRERKTMRIDLRPTEMNSGSKSQNNSSQNPETASIVVRSSLHSGGTMLHKIINPGSQVNEADSIPTTINLSSIAPNISTPSLAPSVSCLSYLKQPAKIFHDGRMIPYVPGIPGPENLSMPLVPVDELHNESATVSIDTNYFKKLEMLKPCNSENDISTTKFLRPSSLPLKPGTFTPKRHHGITPNAHTLALISPETPRPKKSYGQLYLNGHAYTYLGLKCSTKLFYCTLNRPQPMYVRQQDGLSMYSNWKICKEALPSLELNHYDSRHRPARYTLAYTRTEDILTHSSQRRPNTPISPDSELECDGQDKSKRNILKIFSGGFESNEDYTYVRGRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4B0</accession>
    <name>A0A232F4B0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SESTD1-like spectrin repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000984">
        <property type="protein sequence ID" value="OXU25614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4B0"/>
    <dbReference type="STRING" id="543379.A0A232F4B0"/>
    <dbReference type="OrthoDB" id="2152335at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056804">
        <property type="entry name" value="Spectrin_SESTD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46607">
        <property type="entry name" value="SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46607:SF1">
        <property type="entry name" value="SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24915">
        <property type="entry name" value="Spectrin_SESTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SESTD1-like spectrin repeats region" evidence="4">
        <location>
            <begin position="382"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1133" mass="127207" checksum="F3C51597F237E915" modified="2017-10-25" version="1">MLSVSSKYEAANILEALESEIAYVPGGRDRENRALIVLDIPAGEPLPITRKNLELLIDYFLGIFSEDTQANGLTLLVDARSATWRSARSHIRQACLQLGPRAASVIAVRPDGFWDNHRVDNYCTKSHRDGQPIYVSLNRLCVYVDPNQLTYNLGGSKSYDHATWIQNRVRVDEFITDAQNLIAKMNEQKERLSSAEMICSKDSDETLASTKETNLEMMSAAQRILRTGRNLTSSMSRESAQDVLDTVQRIHKLIDSIEQKQVEIEKAWINMERNIDILKEIECLEEGVASVTNWILGPADSMLNSHYQIGFDVASSEELRREHEKLELECRETYGKYAELLHKIDSISSDYLSEDLKSQRDFMDFVCRSFATRLERRRNVLITSQRFFRLVSEYFDKTSEVFDKLIMGSRTCSFLNAGAKLAKLEKSQHKLEGLEIELVKEGEKLSDILSMPVKDALCRDVQIDYGEDIINIQDILDATNARKNIFNDSVELQKLTLKQIALIHTYESDAEQAIRWLDDLFEVLVSSHVEIGCNVAEIQTQKQEHQSFQETARGTYEYGCQLVNGARVLRISCKLDIDDNTLLTSRLRQAWRQLRSVGQEQLTRLRVCAVFHRNVTDHCSQLREMIETVSAFSPKRSRSVTPLRSASASPEAVEAPTSATTTTTTSATTSRHKAEIRDVLAKREKLLPEVGRMVRLGRLLRSRLKEPLAHQSRMSELDDSTSMEGGSGQTGGNLSAVQSISAKLLEVTRLAEKLDKRLCEAGARSQALNPAHEDDEEFCKEEDVRDASVGTTTTTRELAETSGAMEKRSDKLEETNVKETENHSRASDRSAVEDSNVEEYVTATECSTTPVPRSRSESFLSSDYEDALVSTTCESFLSSDYEDALVSTTCRKAEDEMVIKKAEVLPIAKCETTLSTNPPADEEVIEYNPDGATVIQRTIQEKGGKIVKEVTETTILRVSHNTHIGVASYKLVSNVITDHTDNLDYRELQDLNRTILNGDCPSPLPLTTHREEHTYCPSANMFVNYHKSVASGKIEELTDRPSTPQNDLLALENGRSDEPGDLLTQEEKDFLTMVKTVSNELDECTKSLMPMRMPMSIQQQRQHVAIACTSAAAAAVEELQAIMPAAISICELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F521</accession>
    <name>A0A232F521_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_012418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000993">
        <property type="protein sequence ID" value="OXU25578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F521"/>
    <dbReference type="STRING" id="543379.A0A232F521"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1152" mass="131556" checksum="68CA1D22B3DE153D" modified="2017-10-25" version="1">MNFENDLEQNPNSYDDGHDSDLEARLYAEIHFSNNIIGEETNSTTNNQPADTPSSGFKKIDNDRPTEKVVNEPVQTENSSANNGSNKSAVPPPIAIAQNESETNKNNNTSQKRPTVNDSDELNESNKKRKPSHNNESGSNKRVKEYVQPEDSNKIINPYNKNVSHTPAVGMQLLDKEFIDLLFGKRSNNKKKIKTTSKQAKQKKNVKQTNDKVQQQKKIQANTSRVVIENERTNTEVPMDKGIPQNSFLESSSVIDISSEDSTEDDSKYNTTIATDKKLGKKKAAVMESEDSLSDSEESIFEVPVPPKPAPPIIELKDSGSEIDSGSESDDDSSSSDSSISHKSMTQNKGDQSLNSTTATTDNEYNADATINEPDNIVLNCTEIQRGVSSLSKIKEMSQSSSKKQPSLNARDNTPDVEKQQSSSHGSDMCRSKEPQNQSNNSFRKEKVSSTSNKKQSESGRNSKTLSNEEYFFQPMNAAMKAFYNESWGGENFDMDKLKNKMSSDPKKWAILNDDIVASFVKRKRYFGMVCSRCHKDGHRQNQCTEIRKLPACHMCGLTGHTEVSCPEKMCLTCGQKQNMYRKTCENCRKISCSRCQSRGHLSHDCPDLWRRFHQTINKGNAEPPVNLRLIFKSRNELQCCNCARKGHVSAVCNKLRWSQHFPNPEHVTNYNGPGYFQDNEPSRNANDTIESSANRSSICDSSFNIDTTVDSSINLDSRCEASSQNQSLATSPANTVRESGKPWSFEVKPKLIDESASLKTSTLMLDMRDKNALNDYGNWTYLEKFLNSLVAVTPAEFMMQQYGKQVKIRMKCIKKYQKHITQLIQQYASRNNNERSHMLMTCERRIFKVANTLTEKLNELKDLNEDPIKLYEESKQLNWELMNKENRVLDSLDYSLKVSRLAHCQRKLLMTLYREGFLDDSLKKLRRIYKNLTTTKRYLKKPHKMMAFKNFFPYLHYFNNVFSPHEHTELNTAMRKFQEHSARCDRLKNNPLLFPQNHHGLSNESNQNVSSSNNIAALDMPSTSHIPPLLPNYNPAANLSQGRLKTTRETQQKSAEHLKYLKKHPRGLFLESVQNNKKGPKSKLTKKMNNFQEETKRLIDTAKELNLPHLHKHIDILQKKMQNEIYVYEKDVKLLQQHVNEELKRRGERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6F5</accession>
    <name>A0A232F6F5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000889">
        <property type="protein sequence ID" value="OXU26053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6F5"/>
    <dbReference type="STRING" id="543379.A0A232F6F5"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF390">
        <property type="entry name" value="CHITINASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="91"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="451" mass="51605" checksum="F785B8241A74F989" modified="2017-10-25" version="1">MVHKVLVPEADYTLLAGKQKFSCYNVVVVIVIFLLGFTSLGLLAYNFFKTAIAEEKLVHNVKVPSWMHWFWHHNATNSTAFGSTIKPIDEHFVVCYYTKRRDNSSSQLTPNNVDPHLCTHIIVGFASVVNCTLDLGEDLSIYREMVELKKFEPNLKIMVSVGGADNESGYPEMVLNHANRKTFIRSVLNATKTLNLDGLDLDWEFPAWAHKADRQKIHFVQLAYELRKEFDRSGQKLTLSAAVAAPQAIIDQSYIVPEFSEHVDFINLMSYDYHFYIWYYPVTDLNSPLYPRSLETGYLTSLNVNFSANYWVLKGMPREKIVIGIPLYGHSYKLYNPSNHKLQAPARGYGDTGHMGFVTYPEVCKFLKNGAVRVFVNDSHVPYTYKNNEWISYDDVTSVTYKATWIKSNGFKGAMVFSLNTDDWNSTCTPNHRFPLTSVVKKIFNSKPKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F759</accession>
    <name>A0A232F759_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000750">
        <property type="protein sequence ID" value="OXU26694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="417" mass="46342" checksum="237C181BEDFE6E8C" modified="2017-10-25" version="1">MAPNGVRDRVISEYCRTRLQSRPFTHIVMDMYREVVRSAQYAARKRALQHSMRSLPSVPPPPQQQHHHPLGPNVVPMRQNPPPQQQQQPRHRVKGILFKAQSRNSRSQPNLLSLSGQEERYCGGRTNTDGGSYGYVLDARNLHQRTNSQPDCCMERAGGGTTIPQVRSSGNLAVLAAVASASDARNANKPYYGDPIYAMPVKPFLSTQDVRNTNAVARQFQQKQQQQPEICSAAIGRNYGGNRGPGINGALISRLDNADGLCGPTHAPVKEDLYATSTKNGTGRPIILQRQHSSPQFPTTRCGGTQEQKLWEFANPLPESRNGNMLRAGNSEVRHQQQQQQQQPQQTQQQPQQTQQQQQKKLNPEEKIPYVPRGPPPPKPPRIITSLKKAAAAQAALDAQLRTVNVKTQRKENGKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7C5</accession>
    <name>A0A232F7C5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000817">
        <property type="protein sequence ID" value="OXU26348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7C5"/>
    <dbReference type="OrthoDB" id="6256972at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="61568" checksum="C767E1B78DFCFB49" modified="2017-10-25" version="1">MVQNFIEPFNVDVIKVTIKDKPGLPRQTSEESLRRIFQALRQHAQQEGRIRELRLAIEKKTSSRTLKRYFDVWHNRATNTRKIADSRVDGKTLNERKIELLVSAIAEKQKEIIAINEKRDNPLKRSSKSKSDVKPAVINKKTQIKGLGAKSNDVPIKACVRNRLQVQKVIIEEQRAKLAEQSKCIEDMKLKEIDKETKETSKQTISVAKKALTRCDQRTRRSIIHLMREEGCRDETLTEIPRIPSPPRFLMRMEARAEARKQRLKQAEEIRQRKREEEKKKEEMNRRKAEEEERLQQIQAMKNIKKLRKEQEERRLKEIQKNQHMEYIADRCYRRYLFRRYVLEPLNKLVEERYKRLQRADQHYMETILTKTFLAWKEEWMEQQKAKLELANKMHRHNLLWYAFDDWKSFALSMKLKYQVATDFSDMKIQAKYVKVWQALCAELRKKMKEKEAVAIKRHEGRLKLIYFTTWKQYTSMSENIKDREQRRDEWRDLIKKFIPDSPSPQSSLDIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F810</accession>
    <name>A0A232F810_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000802">
        <property type="protein sequence ID" value="OXU26437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F810"/>
    <dbReference type="STRING" id="543379.A0A232F810"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901858">
        <property type="term" value="P:regulation of mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="184" mass="21080" checksum="8CCF51B815311339" modified="2017-10-25" version="1">MSYLFRSYQKLLTRYPLGMQSFQAGVLMGLGDQIAQNFIEKRPVKDLDFMRTAKFFTIGFVIAGPATRTWYGILDRHFGSKGATAVLKKVTCDQFLFAPTFIVVLLSAIGLSQGNDMKSIKLKLEDEYLEILKNNYKLWPMVQLVNFYLVPLHHQVLVVQSVAVLWNTYVSYRTNRGTLTENTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F833</accession>
    <name>A0A232F833_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_007956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000758">
        <property type="protein sequence ID" value="OXU26650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F833"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000003">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="2050"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="2277"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2416" mass="276230" checksum="F26B99C3FEBE5CEF" modified="2017-10-25" version="1">MRPKSGRFCGPQSDGYIPVEAVPIYEYSKTLRAKRSSSSLAHLGKDANRRSDYNGRATPLRELQQQQQQQQYSNTIEVEQELRTGVNLRKDELDFRSLDREPTSILSSNYNAYSPKFPYTYGITINYSKRSLKEKTQMQKYTTIFQSTHQFTLSKVLGTPECRQKRLKSQRRSRSSDVSAQISKSESSESPTSESRRSSTFSRRVRQPPKTSLSAPSTPMRIRMDKHGRNKVQNKKLPITDIKVDTSIVARRSLLPLIKGYYQESAVPAWQQTAYPLASIYYALNADTDPTRRIGDFIENSAVRPHFKPPTLHCDPYLEEEARIRYLETKPVCYIVFGKPGLDVERLAESIAIERNSVLISASKILRDIEENGDLRKRNEFECGCDSREDIAWDIVLDRVDKRDILHKGYVLEGLPITQSCKPSIVSESVKSKRSSESVEENDHYLLIALQTESTASEETVITREAFNSQKSTSSSELSVQSTSVKSLCSMLSNNNNTDSLAISTFASESSMKSAQTCACSNQASDDTKCSSTAAASIQLEEIFNNWHLKPDVIIRVSCPDDEILEKHNVRDSNSESSAEQIERESDSLSELSDMLSNKLSNNANSETQFGNPTERLIDELRNYEENCAKSIEKVISSHNPQNVIRIDGRYSFDHCFQSIKIRLELLPLRVVIIPRRMSELASNFGSSDDETESENESEDYEHESFENFEDENLNLKRVFDEIKRSEIPSDKFQWKLSRWKFLCPVELAKGRKIEGRKKLAARFMNWVFFLSSSEAMEAFIENPRPYLLPPNPRPYCRITVIGPRYSGKTRLCFDLARNLDSVVINLRDIIARLTREATGSFDTSELVSAIVESTENLPEQDCGDFSRNRGWILDGLPLDFELCKKLLENDVHIDCVIVLFESEPYSKSMEAFFKMQDESSEQSVIEESCESSIEETSQHHIGKSFSLSQYEEQLKYFENNRKVFANKLSHIGVDVILCDLQKIDDVSDHIISQVRKDYQFTVRQLDEKDDDYLDDDDEEDQVEGSSTETNGTTSSLSSQQDSNLLLGDCNVFCPIALIEHKVLWKGKEKYRCLLDDKLFFMSSESSLHNFVNDYTKLQLPLSKPFSHIPPLRIFIVGPPGSGKSTLAKLISREYGLAHIDFYKRLEEYALSRGIDVKHLKSKYANQYEEENSSEDSFEEVESPEILDDSKYDTDKARISSFFIKYKKEGTPLPRAVANECILNFFKTPFDQCGIVVDSFPNCIEDCEMMLKLFAIPDVIVELECSYVDSEDRSLKSMMAEWKLEQETKRNEEETRFSDLMKNYLDKKDEWTRQEKLRRYKERKLDLEEHESSLSENSSADLPESLSSSYIIDFMSVITTEDEIEIEETFYKLYPEPETLDDWESEESAKQKFAMQFEADYERSSQNLIFMANFFKDENIPWIKVDASPKANKVFIKTSLILSPHIQRNASLFEITHELDNLTAENLLSSGYFFLSSFGRLCPVQSFNGTNPFQMFVPLASKGQIFSVLHRQYVYFLAGKVALSEFKKDPLKYLIGQDSQHPMIPALISIIGPPKCGKSTLANRFASTYSFEVVSRHEAINYVLDNFAATNLSSSIRKNFQNGDTATPCQLAAAIKLFLCNPKCVTQGCVFDGFPASSEEAQALASLAIIPFVVVDLKAPFEFTFECIEHDPNHVYSSPSHFQDFESWKTDAQEYRRWLAEQYGNVVEVDATRSKAAVWRRADEHVRYMFGKFFDYVREVGYEKVHDLENLCATPQEIQKRTSRFQLYCPGCAYFDKTFLSLNLSKSRKGLLQFREHFYWFCDRHSTAFAQAPHRHLRLFEKLDLPDTHPEILAHDVVDLENSFWSSRLANGGYCLVTYASQLPSRVLIRGKPSLGVLYKNRLHLFCSEACRGKFRAGFPGYSGLEIHFPRTLEQLRVKNLPTRGYLEQTLAKPLARAVSRVGELRPKLPGMSSRDTAAVFIGAYLKARSGGDDAEALRRIEARCRVFRDVTEAVKKKVNPWVVQKVGQGDERVVKIDDFAGKEVSEVDLFEFATVKVPVPDARFDYLCEYFKPASKVPAFLNVVDIAGLVKGAAEGQGLGNAFLSHISACDAIFHLCRAFEDDDVTHIEGEVNPVRDLEIISEELRLKDVEFLNVHLEKLEKLVVRGNDKKLKPEYDCLLKVKQVLVEDKNHIRFADWSANDIEVLNKYLFLTSKPMIYLVNLSEKDYIRKKNKWLIKIKEWVDKNDPGAALIPFSGAFENKFIDMDEGERAKYVEESKVSSALDKIIVQGYKALQLMYFFTAGHDEVKAWTIQKGTKAPQAAGRIHTDFEKGFIMAEVMKFEDFKNEGSESAVKAAGKYRQQGRNYVVEDGDIIFFKFNAGAGLKDAKKNAIVHLHVNNSDPHDSLRPIERQGHRNNRHNLPLFYNESFFYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F899</accession>
    <name>A0A232F899_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000750">
        <property type="protein sequence ID" value="OXU26698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F899"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="16" mass="1669" checksum="034B81081698DD37" modified="2017-10-25" version="1">MSRTGILPPTEAVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8E5</accession>
    <name>A0A232F8E5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000738">
        <property type="protein sequence ID" value="OXU26748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8E5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="13112" checksum="6DB946DFE5E94335" modified="2017-10-25" version="1">MVLFYTAQLVPERSEGAKRHVKLNHLSQEYPQTAKVRKSRLFVTKVVLICTVRLTNSLRSCANLTVQIRTTLVTNRRDLTADFSHTTEKCVTDLLTHFERCKVSQEVSTELQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8K1</accession>
    <name>A0A232F8K1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000658">
        <property type="protein sequence ID" value="OXU27146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8K1"/>
    <dbReference type="STRING" id="543379.A0A232F8K1"/>
    <dbReference type="OrthoDB" id="5959275at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023340">
        <property type="entry name" value="UMA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51497">
        <property type="entry name" value="UMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UMA" evidence="2">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="141" mass="16365" checksum="B794BF626D53288C" modified="2017-10-25" version="1">MSWFFGKKKHRDSPPDSPQEPAPSDDGEFIFIERRNQPEPNADDKPPSLYPSLSNITPYPSMPMAPFVKQGSQEGPTNYLTNIPFKFCKELERNMNEDLVIDQLRLNEIESFIKRINADNYNYEFSVERSVIAEMDSQNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAV8</accession>
    <name>A0A232FAV8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cardioactive peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000599">
        <property type="protein sequence ID" value="OXU27467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAV8"/>
    <dbReference type="OrthoDB" id="6134464at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024276">
        <property type="entry name" value="CCAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11105">
        <property type="entry name" value="CCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895594" description="Cardioactive peptide" evidence="1">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12219" checksum="F5C89E40C214CCC8" modified="2017-10-25" version="1" fragment="single">QVLKLVLSLLIIIESVEIARADDGLEIVAMKRPFCNAFTGCGRKRDPSYASGLQLPIPLYRALLRLSSLRNGAAAEVRMRQRPLGLIGPENLAQLGPQAPRLMAPVLVPSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBC0</accession>
    <name>A0A232FBC0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dihydropyrimidine dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="17">DHPDHase</shortName>
            <shortName evidence="17">DPD</shortName>
            <ecNumber evidence="17">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_002631</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="17"/>
    <dbReference type="EMBL" id="NNAY01000475">
        <property type="protein sequence ID" value="OXU28124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBC0"/>
    <dbReference type="STRING" id="543379.A0A232FBC0"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000007">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000023">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 17" id="KW-0288">FMN</keyword>
    <keyword evidence="14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="942"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="976"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU28124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111137" checksum="32B54C2943B13D84" modified="2017-10-25" version="1">MAATSSLVVSKDIPDIENLLSLNPRTKPYASVVPSSQTKQNKQHWKRNIHSKCDSCTPLTKNFDDIKHTTLSERGALYEASRCLKCADAPCQKSCPTQLDIKSFITSISNKNYYGAAKAIFSDNPLGLTCGMVCPTSDLCVGGCNLFASEEGPINIGGLQQFATDIFKQMNIPQTRIPGQTVAHANTKIAMIGCGPASLSCATFLARLGYDDITIFEKQKYVGGLSAAEIPQYRLPYDAVSFEVDLVRDLGVKIEFGRELSEKDLTIKKLQNSGYEVIFLGFGLPEPKSVPIFEGLTPEMGFYTSKNFLPAVSQGSKPGMCACKSTGLPNLYGNVVVLGAGDTAFDCATSALRCGAKKVFVVFRRGFTNIRAVPEEMELAKDEKCEFIPFASPKKVIVKGSKITAIEFYRTEQDENGEWKEDEDQLVRLKVSFVISAFGSGLYDSAVKNALEPVKLNRWGTPEVDGNSMRTTVPGVFCGGDLAGVSQTTVESVNDGKTASWYIHKYIQEKHGLTVPKEPQLPKFHTPIDDVDLSVEVCGIKFENPFGLASAPPATSCAMIRRSFEAGWGFAVTKTFSLDKDMVTNISPRIVKGTTDGYHYGPEQSSFLNIELISEKTAAYWCKGITELKRDFPEKVVIASIMCTYNKADWTELAQMAEATGCEALELNLSCPHGMGEKGMGLACGQDPELVRNIARWVRAAVKIPFFVKLTPNITDIVALAKAAYEGQADGVSAINTVQGLMSVKADGTPWPAVGSAKATTYGGVSGNATRPIALRAISKVAKALPGFPILGIGGVDSAEVSLQFLQCGARILQVGSAIQNQDFTLIDDYTTGLKALLYLKSVGHLKGWDGQSPPTFKHQKGKPVSLQHALGQSVPYFGEYQKLREKKAAEIKEQSNLLDVELKPTRPAPKPVQPIPTINDVIGKALPHIGNYTQLDNKKQVVALIDDDMCINCGKCYMACADSGYQAIQFNAETHIPKVTDDCTGCTLCLSVCPIIDCITMVPKKIPHVIKRGIPPKGITELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCP1</accession>
    <name>A0A232FCP1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_004783</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000414">
        <property type="protein sequence ID" value="OXU28571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCP1"/>
    <dbReference type="STRING" id="543379.A0A232FCP1"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="59"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="258"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU28571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="475" mass="53203" checksum="757BA5062614D202" modified="2017-10-25" version="1">MVTIIFTEYRMNRECISIHVGQAGVQIGNACWELYCLEHGIQPDGTMPSDKISGTNDCFDTFFNETSKGKMIPRAMIIDLEPTVIDEIRNGTYKQLYHPEQLISGKEDAANNYARGYYSVGQDIINLVTDRIRRFTEQCHSLQGFFIFHSFGGGTGSGFSSLLMEKLSNDYGKKSKLEFTVYPAPQVSTAVVEPYNSNLSTHATIGHSDCTFMVDNEAIYDICRRKLGIERPSYRNLNRLISQVVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLASYAPVISADKAYHEGMSVGEITSECFEPGNQMVKCDPREGKYMACCLLYRGDVVPKDVNSAIASVKSKSSVRFVDWCPTGFKVGINYQPPTVVPGGDLAKVHISLFQFIVSTCSETNIQRAVSMLCNTTAIGEAWSKLNFKFDLMFNKRAFVHWYVGEGMEEVEFIEAREDLAALERDYEEVATDSIIPSDSNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD95</accession>
    <name>A0A232FD95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000427">
        <property type="protein sequence ID" value="OXU28473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD95"/>
    <dbReference type="STRING" id="543379.A0A232FD95"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="284" mass="33582" checksum="0DCE795685B1C754" modified="2017-10-25" version="1">MHSEKNRLQNRTFSKSLVFSPTAAFPPTPVSSFISFWTFRVSGRVYLLRLYLCTSIFVLVRGKEAHILLHVVDKAFANTSTMSDDEKWMELGREMNRDRQEIRDAYDKPDVKKIEDDEHVHHDLDDLVLVANQESTGLIEVQTVEHDQYLDEIQYADLDGQLCNVDEFQHQLMNNPQILDDMSHLDQQVYVVGEKRQLDSIDDYDKHKLEELQAHITEELNLRREEHKKKMEVYTMHLQQGQEIHKERMKLLKAKLRKLQDEVHHIDYVICNRNLKRKFKSGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDA3</accession>
    <name>A0A232FDA3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000432">
        <property type="protein sequence ID" value="OXU28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDA3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="9931" checksum="3A4C718CD107304A" modified="2017-10-25" version="1">MGLMEILRGHLHDGNALGAHSHVCLQGRESQHTYPIRRTGSARTRSLLSDSSTSKILRIRASGCCEISRYTCLEPYCSRIKKSACVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDQ0</accession>
    <name>A0A232FDQ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000407">
        <property type="protein sequence ID" value="OXU28608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDQ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="15142" checksum="5D73A72D115B7BA2" modified="2017-10-25" version="1">MKRMCHQLQELEEKVKNLEMLEASQTRSPLAGAEQRRTPSANPKQTPVFSTSQKVKTKQINEPAQVPKGQTKEEVRKSVPSSNGPRLVEQVEQRQVAFLDRGVEKKLSPPSLWSIWIMLRKTNILTSIYTGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-05-29" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDS4</accession>
    <name>A0A232FDS4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000397">
        <property type="protein sequence ID" value="OXU28670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDS4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8350" checksum="8E70FA3BE43B17F0" modified="2017-10-25" version="1" fragment="single">NNYNAYNSTLRMFTCISKLNIFGHKRSVNIETKTNDQNNSQLHGLYASPAISSLHHQNYPSLGVESQVVNNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE79</accession>
    <name>A0A232FE79_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.</text>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DIPP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000371">
        <property type="protein sequence ID" value="OXU28833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE79"/>
    <dbReference type="STRING" id="543379.A0A232FE79"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000002">
        <property type="entry name" value="diphosphoinositol polyphosphate phosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="190" mass="21636" checksum="40C46530D252EB8C" modified="2017-10-25" version="1">MVKEKPNSIRIYDSEGYRRRAACICVKNDLEDEVLLVTSSRRPDSWIVPGGGVEPEEEPAVTALREVREEAGVLGQLGRCLGIFEHTIVQQNVEHKHRTQVWVMRVTEELPEWEDSRSIGRKRKWFSIPEALLQLAQHKPVQRSYLHSLHNTNPRSNNSGMPLAQYPLSPMAPIQLVNNSGSSPHFNKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEN6</accession>
    <name>A0A232FEN6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000347">
        <property type="protein sequence ID" value="OXU29013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEN6"/>
    <dbReference type="STRING" id="543379.A0A232FEN6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012737257" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="4">
        <location>
            <begin position="49"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="253" mass="28974" checksum="05FB0B7832713BD7" modified="2017-10-25" version="1">MGARIGLCLGWGPTTTTMTMLLLCGVVVRAVRQQESCQNISVAGPMTQTELLQELTNECRYDKMVRPPGELNERDPVKVWARAYIYTIKSNMAKTLQFDVHMMLQFRYLDTRLKFEDIAPHQNQIYGGQSAHDLIWTPSVYVANERSSVIMGNSVKDLLISIDPSGMVVLNTRLEAILNCGLRLEKFPFDVQECPMVFESWTHNVQDMILNWDEAPIVLADELHLTEYRLVEQWVNRSEVSYTTAQQHYGHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEX1</accession>
    <name>A0A232FEX1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytosol aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000338">
        <property type="protein sequence ID" value="OXU29093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEX1"/>
    <dbReference type="STRING" id="543379.A0A232FEX1"/>
    <dbReference type="OrthoDB" id="10041421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF48">
        <property type="entry name" value="DIPEPTIDASE B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="256"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="712" mass="76700" checksum="622596D48842D4D4" modified="2017-10-25" version="1" fragment="single">MSTRAIILLSVGRRGVGRRIFHQNLDCSKRIISSRSLHICARPNIAINRSFAACTSRLLQLRLPSSGKANCYSTYCHDMSIYLPSQLKIETNVCSPDYDGIVLVSGTPPGSEEPEPFKSVLFCAAQIDSGLFELGAVLPINLPAKRLIYSPTGSINPDYDDVRVFKEAAVKGIKRALQAGVRKPLLVLLPDSRFENTELVTLLGALEALYVPLEVREIGPERTHKAAQLAVWSPICSKKLQGVVKLAGALESGRYVARDIGGSDPERMAPPRVEEYVRELFANTRINVQVISDLPTLEKEYPLFAAVNRGASVIPRHAGRIIFLTYEPQDPSCVLETVMLVGKGVTFDTGGNDIKVSHGMVGMSRDKCGAAASVGFMQTVNLLQPPTVKVVAAIGVVRNSCGENAYVADEVVTARSGARVRVNNTDAEGRFVMADILYHVKEMAMGSVNPHIFTIATLTGHAMRTAGDGFSIAMDNSVARSVSNAYKLQACGDVVGDMFEVSIIRREDFDLHKGKMEGDDIIQSGQKSSAATNRGHQGPCAFLIMASGLDKHGKTSEKPLEYCHLDIAASAGNLPDPATGAPIAALSKRFLAKEFEENLAEANGAPLKYTHIDMAGQLGLGLNFYDGNPLLGLAYCYLVQGKCLTIYTCPPGCELISELDCKPVVAAPTRLCALRSAGSVQESLTGKMVQLVCSEEDAGVEEECARSSKSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEX3</accession>
    <name>A0A232FEX3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000341">
        <property type="protein sequence ID" value="OXU29070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEX3"/>
    <dbReference type="STRING" id="543379.A0A232FEX3"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4-LIKE WD40 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="165"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="440" mass="49617" checksum="B4924249D8C04E9A" modified="2017-10-25" version="1">MLKVRNHLSVYYRIFSCMIFQYNTTMESLKTDETSSSSIAKVHSLFYKDRPEKACKQLTGFLVDRKISEEEIRSRYEWIKTKRLKSNDTVKDQNRVTRKVYFPDTLCGLYCARFSSDGETIATTYGSGCIQLRNGETGELRVTIRSSLETSLPVTCCRFHPIQKEILYAASACGSIFICKLDNIEFWKFVEELDNEINALDVNISGDFIASGGKDASLKVYDAETGKVNTLEFIYKIKNLLKNYQKDKANLITENAVRFHHMKIFSIKCHQTNKNVIVTGGWDDTVKIWDTRVGDGSIRSMHGPHICGDAIDLQVMFPSIINRAIFKDTNILTGSWTVKDSLQIWDFSSAKLIETVNPTNREASLSGEFLYSARYFDGDPYGDHVLVGGSGTGNVEVINLKEKSIVARFMANKAVVAIDSYKSSIVYGGMDPVISIADYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFF3</accession>
    <name>A0A232FFF3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Parahox neighbor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_006561</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OHCU decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000332">
        <property type="protein sequence ID" value="OXU29159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFF3"/>
    <dbReference type="STRING" id="543379.A0A232FFF3"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3330.10:FF:000001">
        <property type="entry name" value="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU29159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="176" mass="20087" checksum="000EE84AFE25467D" modified="2017-10-25" version="1">MTSKGILSISEVNALPAENFEWLFANVIEHCPEAAPIVATKRPFSSTEDLKRAFDEYLEKLDTDEKELVLLKHPDLAGKLAEDGKLTAESQNEQKIAGLDTMTKDDRQTLSNNNYLYKEKFRFPFIICARQNKVQSILSGLETRLNNSRETELKTGIDEVKKICRVRIDDLVWPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFS8</accession>
    <name>A0A232FFS8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000267">
        <property type="protein sequence ID" value="OXU29611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFS8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19051" checksum="ECFF358A81864EBF" modified="2017-10-25" version="1">MKLVGGASLDKLENETNIANITAYFDSKLFEYDLSTIQPIIIARNAWLNDDSIDAFLNIVQEEHPQFKVHAQGNDVLDNKMVIQYAYMIPNYTGGKPVKQEKHYILQRFPSILECDINFVDIVTKQPDRYECGVYSAALLTCLILGGDPSKILQCRRVTPFPIAATGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGD0</accession>
    <name>A0A232FGD0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_016303</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000272">
        <property type="protein sequence ID" value="OXU29580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGD0"/>
    <dbReference type="STRING" id="543379.A0A232FGD0"/>
    <dbReference type="OrthoDB" id="25246at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001458">
        <property type="entry name" value="EBF transcription factor 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3180:FF:000004">
        <property type="entry name" value="Transcription factor COE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4280:FF:000001">
        <property type="entry name" value="transcription factor COE1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IPT/TIG" evidence="12">
        <location>
            <begin position="125"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU29580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="460" mass="48575" checksum="9E834345F8044EE0" modified="2017-10-25" version="1" fragment="single">RSGQVSANGAADVWHSAANYSFLLRRLALPATAARYASERKRVSFFLKFFLKCNQNCLKNAGNPRDMRRFQVIISTQVGVDGPLLAVSDNMFVHNNSKHGRRAKRLDPSDPGEYNSLYPPLQMATPCIKTMAPSEGWTSGGQSVIILGDNFFDGLQVVFGTMLVWSELLTPHAIRVQSPPRQIPGVVEVILSYKGKQFCKGAPGRFIYVSNETISPEALSEPTIAYGFERLQKLVPRHPGDPDKLPKEIILKRAADLAEAVYSMPRSSNASGITSSAPRSPGSSHAAQPPTSSSATAFNSYTGQLAVTVQENGTSSKWTDDGSTSVTTGAGSGGGNNGNNNNNANNNSGGNGPGSNGGSANANPDAYRQSSSASPRGVVSSGGGYCGSSASTPHSHSTSGSYSVANPYTGSPTLYTSPHEQYGIFYSSGDSSAFAPVVRPPTTSVPPHWSTQHHLATAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGF5</accession>
    <name>A0A232FGF5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000282">
        <property type="protein sequence ID" value="OXU29509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGF5"/>
    <dbReference type="STRING" id="543379.A0A232FGF5"/>
    <dbReference type="OrthoDB" id="9886517at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF11">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="531"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="69945" checksum="BD6B9B9BC4896843" modified="2017-10-25" version="1">MYSFPSCKLPTIVTGAFCDMKKILCFIVFCLTSNVWGEASTTVEPPTKLKTCANVTRITVAVNLLDKECMKTSGTSAILLNDDENNVEVKDIEMNAYALCLLQKSSIMNEQGKINLNFDIFKIVKNLYKRTDQRGFGLAFIIKSLEKCRQTDGPDQFSTATKIMKCLLDNQKTVIRCITFNLITLLTVRLSPDREIFRNRMALFTPKNHPWKPTTGYETTDAFPVPSLPVTSQRMLPCYIPSGMCTAPLRFPNLVDGFNRSPIHAARAALSTRYESSKWLENHNSLMEEVSANLSISQAIRDNLDNLVRQEKEKLKACKIDDEGTKNTKVATLNWLVSKVDELSSVQEKVIGENEEWQDCRRKLQACIQGIEAPLQIAQECLFHRESRNKSELVNDKVEQMLLKEVETFRQNQKDLHKYLEQCEIQLIQGRKIQSELENFLRNVQWIALVDRSDKEIKRIAESKSWMEEFQCLAKKSDQAITSSKHLRKQIDAIVNEMTQDILKTWNETNDAFSEKRTHVKQAIDEIEYGLKKIKNEIFNVEKNLKYLKTNKGIFNELQQGQDLLESLLRTKRNLESELSSKINSLFIDDKKCMTIRNCYPIIMTTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGF7</accession>
    <name>A0A232FGF7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000239">
        <property type="protein sequence ID" value="OXU29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGF7"/>
    <dbReference type="STRING" id="543379.A0A232FGF7"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20508">
        <property type="entry name" value="CYCLIN_CCNB3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="286"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="379"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="383"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="535" mass="61158" checksum="F142A63B743CC91F" modified="2017-10-25" version="1">MAPSKVLQTKTTAASQVTGVVTRRGLATRQQNAVISDPKQHALLFKDTRIKRKADASPLKDKTTKRSALGNITNAIGKSIGAQLQDAKKAAKKVTVSQPVKSVTQTTSTLRTLEKILNIPAENNVIHRHPKQVVRAKAPAKKEEERPEIPSKIANVRRSLDLEKSDDSSLYVSALETLPEENVKRLSRTGKDADKKSPVEKVQESEVEVEEKTEAPVNRNPPPERELPEGVAWDFDVENWQDPYQVPHYAMDIFDYLKERESLFPINDYMERQVCLSRWMRSLLVDWMVAVQESFELNHETLYLAVKLVDLYLTKVTVGKETLQLLGAASLFIASKFDERIPPMIEDFLYICDGAYSHRELIRMEMSVLKVMDFDLGIPLSYRFLRRYARCAKVSMPTLTLARYILEYSLMDYTTISFSDSKMAAAALFLALQMKELGGWTTTLEYYTGYKLSEFKDIVLTLNEGLHRKHKDALSTVRNKYSHKAKPLTARQLESRMRERQEKSETLLDIESRASMFLQSLCDTWLKKKTRTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIK1</accession>
    <name>A0A232FIK1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000154">
        <property type="protein sequence ID" value="OXU30502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIK1"/>
    <dbReference type="STRING" id="543379.A0A232FIK1"/>
    <dbReference type="OrthoDB" id="7679868at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624348" evidence="2">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="247" mass="26922" checksum="DB74F600957FF9B4" modified="2017-10-25" version="1">MTSRGIIVICCCLVVPGLANPMMARQAESEVDRFEARLASIMDSLNEKDTIGLYGDMVTLERVAVEEQRSATEEAEDDPLMRRIDDFLRSHKLQISFPSDGSSADLFGRALGEKNVGFELRGLIQGASEGRTKLKKILLPVLLALKLKAIIVLPIVITLIGLIGIKGLGAGVLALLLSGAVALKALLTPPAPAYPARVSYAKPYEIHHDHWHRSQEEVGLQAAGPYRAWSPEFSVDPQFSPYPEIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ23</accession>
    <name>A0A232FJ23_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01000132">
        <property type="protein sequence ID" value="OXU30675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ23"/>
    <dbReference type="STRING" id="543379.A0A232FJ23"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13093" checksum="B6F7AD4F9DC0EAF6" modified="2017-10-25" version="1">MLIAHLQVPSYSHLVTGQQAVVRELNRLGMLVDLSHVSTQTMNAALQTTKAPVIFSHSAARTLCNASRNVPDDVLQNLAKNGGVAMVPFYTYFITCNSTATIQDVIGECNYNNVWNIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK24</accession>
    <name>A0A232FK24_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000116">
        <property type="protein sequence ID" value="OXU30818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK24"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="31" mass="3688" checksum="0826A618BC2F2ACF" modified="2017-10-25" version="1">MDRFIRSTRGRKFESTRQIGLGPRKESDIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKR6</accession>
    <name>A0A232FKR6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000073">
        <property type="protein sequence ID" value="OXU31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKR6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="28" mass="3018" checksum="36A03C1D0F96E68B" modified="2017-10-25" version="1">MVLSLYLSLKYGAILKGLSGVCYAKGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLA4</accession>
    <name>A0A232FLA4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000070">
        <property type="protein sequence ID" value="OXU31290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLA4"/>
    <dbReference type="OrthoDB" id="6119432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12299" checksum="C279A5DEF2B47C5E" modified="2017-10-25" version="1" fragment="single">LKQTEVIKSRESLLKLLTCPERDVNDILTINDKILYVNWQYKDEAVTPAPHTSVVIAAYTTAQARLELYNYLRRLGDRILYYNTDSCIFVSHDVLRMSINLLLPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLG3</accession>
    <name>A0A232FLG3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000047">
        <property type="protein sequence ID" value="OXU31581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLG3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="283" mass="32747" checksum="4E2F419308D6D00B" modified="2017-10-25" version="1">MLPRTPHKQDAPAHSINNSREVDLLYLEQTNLEDTNVTGHTQSSQTPIPTTHTNVPKINNLKIQLENEHAQRKDLEVRLSQRSVEEVNISNELRRRDQDFLSEKRLRENYEEKMKHLVEDNERLQWSIEAERSDWTREQQDLERRLTELSHSNISDMYINTKQRISTELNLVDTHFAHANNKLELPPRNTIRNQSVLSTNAAIDNTILKRSESISTLRKITELNLGYFLDILEMSIKNLILQLLGSFCFRPAKFGSKDLLSEMSGFLMSSLTSLPFDGGGRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLP5</accession>
    <name>A0A232FLP5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLP5"/>
    <dbReference type="OrthoDB" id="294541at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="141"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="515" mass="57690" checksum="71222DEB3FF1F07D" modified="2017-10-25" version="1">MPEISSGEQYSTWVGLVYVFNLMVGTGALALPAVFSRAGWLLGSGVVLILAFISFITVTFVIEAIASANAIMTWRKIQQRKRVGLIQDSAFTGPELEAMQAIGESGPSNSDSEDTPLVTPSPRSPERAGSTYRYYVITEKIEMGEMASIFFSKMGVTLFYICLAIYLYGDLSIYGTAIAKSVTDVVCTYLPVNYTCNETIPDSELCWQSYGLNRMDAYRLFLTLFVMFLGPFAFFNVQKTKYLQLLTSAMRWMAFMIMIIYAIRKLIVDGPEGKPRESNFSELPGLFGVCVYSFMCHHSLPALVAPISDKSKLNKSLSFDFILISFFYLLLALTGAFAFEQLDDLYTLDFGPRNCSYGENFFIVIIQYFLALFPVFTLSTSFPIIAITLRNNLQSLFLKEGETYNLCLRKLLFPVMAVFPPYLIAMSTKNLSVLVSITGSYAGTGIQYLIPIFLVYNARKQTAEIIGQGVINKFASPFASTRWIIFIFVWAVVCMMLVSLNFIKKHLSASLGNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLX8</accession>
    <name>A0A232FLX8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLX8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="10986" checksum="B79B3D7B79220976" modified="2017-10-25" version="1">MRLCQRSHRVRGREEPLGYERDGLDTLKNLTDILDCDIKNEINSGTSGPLYKLVFNFMSSDRSSLTMTPSIANTTSTADAACSTRIGAFLSDYRIIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLZ0</accession>
    <name>A0A232FLZ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLZ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="9969" checksum="A3703BDABD454286" modified="2017-10-25" version="1">MRSYQFRGDVRVSTLLNNACKLKLRLNSHGVRGSITTTAERPFSPPYYLCKDEFSEYSPQVAKNESSCGGGLFGRSNSNVLSKIMWLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM07</accession>
    <name>A0A232FM07_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM07"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="208" mass="24483" checksum="3F31DCA3372D59F5" modified="2017-10-25" version="1" fragment="single">MTYGRECEDIAQKEIEVVTKKEIKFRGLFIDLKDRRFAASPDGIIDGLVEITNSTSKEYYQVQGQLHVTQQNYCVFVLRTPKCMEIRVVRRDDDFWNSKIEPFLSQFYENCLLPEILNSRFLRNMQIRNPRYILDAIKKQHQKISDQGVKKSSALKNMNPDDLLIQLLETEKNRRNYDKIALTDLSVTHSTHKIDRLTIATMMSFTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM68</accession>
    <name>A0A232FM68_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000024">
        <property type="protein sequence ID" value="OXU31846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM68"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="295" mass="34157" checksum="70DC2A643EC432D5" modified="2017-10-25" version="1" fragment="single">HNQTCEKRATFKYRFPLSNSIRLFTTSKTSQQAKTIKATENRIIISESPSKPSNSPQSLIKILAEAHNKTVNQNEDYCDAVPTLLNINPFTIPRRKSSLTLIRSNFSRGKDCTLTEYALKRKAQKSRRHKYMDIDGTAKVGGEVSFESYQDLEDSKLAVFIYDRNYDRIFTEHIDQSLKNLQSRECILEYVKDRTKTRICIESEWKAEEILHKYQKAEDGSLILKIAKPPLVYFNPEFRIKLQQTFDQVNKKILQEENDDRHEKSESEHFFVKLLAVILASGYTAATLAFMISIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FPA1</accession>
    <name>A0A232FPA1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000003">
        <property type="protein sequence ID" value="OXU32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FPA1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="10513" checksum="C1214385D3EAF6C2" modified="2017-10-25" version="1">MLKEDSFRMIWRKLIFVLATVHTVVLLMNLMLIAVMNHELTKIKIIFLIIIRIYQQTTLHLRKITYQMQKISQLQVLLIKLRETYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDU1</accession>
    <name>A0A232EDU1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_005115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01005912">
        <property type="protein sequence ID" value="OXU16521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDU1"/>
    <dbReference type="STRING" id="543379.A0A232EDU1"/>
    <dbReference type="OrthoDB" id="7700898at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="11">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="312"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU16521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="680" mass="78539" checksum="E18A3CB210B0DD17" modified="2017-10-25" version="1">MAYASRAVRALRKNELNYSTTERECLAIKFAIEKFRPYIEDDTFTVITDHRALQCLYKRKDPVGRLGRWAQELISYDFKIVHRKDDESVLINAIEIKEITSDKWNKKRLYQISKHPRRYRDWNVVNGNIYRYKPSKDIEDIMTDLDAWKLVTPKDKLDKILEEMHSEPSAGHSGVDKTYNRLVHFYYCPGAYKDTARFVKNCKICQQLKTEQRAQVGLMGTRDVDRPWKIIAADLMEEFPRSKASKTPAFLIFVHELHPPKLWRREVKAQIETDPEKSSSANRNANESIDKADINDSASSQSDGSVRKYNTWDRKKKKLEKLEKKRKAEKENNISETHKANDIKENENYILNNNSLKDKVNDWTERMQKLVHVHDNTLVQVDKEKREDVYTLQDINGKNLSSSCHAKALKEFTGEEKPEKSGNAAPPEKPKRKPGRPPKQRAKTKKQQSAHLPPPLSTQQQHPPIAQTTIVANSSSSESSSDSEIDPRVLKKLLKYQKLLSKEKSEKKSRKVRAKSERVNSITSAHTGNSPTDKESVKDAAETSFGARTPKHQQSSHRDKIFRELRENQQQYLAEQERRRNLETSSRMSEQERQRREDVYTLQDINGKNLSSSCHAKALKEFTGEEKPEKSGNAAPPEKPKRKPGRPPKQRAKTKKQQSAHLPPPLSTQQQHVPAPTQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDY0</accession>
    <name>A0A232EDY0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005800">
        <property type="protein sequence ID" value="OXU16557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDY0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="56" mass="6404" checksum="996938BEC6DC450B" modified="2017-10-25" version="1">MSRVYTRHGFRITIKRQAEECNVVAALARRQSVCLASQRISVQARGPSLFRCTFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEU9</accession>
    <name>A0A232EEU9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005213">
        <property type="protein sequence ID" value="OXU16875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEU9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="18581" checksum="82887BF6D2444AF4" modified="2017-10-25" version="1">MADTTITVSEAESETDPTKNNVNVTLTTQPNGILVTHSHVPQNPNGTATLGLNFNPMEDSRRIIADNLSTTIAVNTILWEKLSHVPILPKIIGEKMVRALLYSPHTSRRTGKWRCCTFPILLDHWIISYWILQRNFLLRRYHERSLETVLPVSDLLKRNSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEW6</accession>
    <name>A0A232EEW6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins. Required for ufmylation of Atg9; protects the nervous system during aging, possibly by stabilizing Atg9 and supporting its function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with Atg9; the interaction is transient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDRGK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005198">
        <property type="protein sequence ID" value="OXU16900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEW6"/>
    <dbReference type="STRING" id="543379.A0A232EEW6"/>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000143">
        <property type="entry name" value="DDRGK domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU16900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="290" mass="33008" checksum="898CCF53BE62F2A0" modified="2017-10-25" version="1">MDIVLLVSIAALLIVLIVAVTWFSKKSSKKVRQDGEGVGAPRGPAVRRAAGVRGVRQRRGAPRAAAAEEQPQEDEEDEAEEAHNAEALDAGKVGSKKRAKMEAKAERKAQREMEERDREERKKREQQQQEERDRQSVREREEEKRREEAEKAAQEEKERREHEEYLKLKAAFSVEEEGYEEKDEEQQKNLLQEFVDHIKANKVVILEDLAQHFGLKTANAIERVQQMQADGILSGVIDDRGKFIYISHKELEAVAKFVRQRGRVSIAELAEHSNNLINLNPGTACNLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF41</accession>
    <name>A0A232EF41_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_016653</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005161">
        <property type="protein sequence ID" value="OXU16932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF41"/>
    <dbReference type="STRING" id="543379.A0A232EF41"/>
    <dbReference type="OrthoDB" id="435430at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08834">
        <property type="entry name" value="ArfGap_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07604">
        <property type="entry name" value="BAR_ASAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13251">
        <property type="entry name" value="PH_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000006">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000322">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037844">
        <property type="entry name" value="PH_ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF3">
        <property type="entry name" value="ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854">
        <property type="entry name" value="ASAP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="302"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="14">
        <location>
            <begin position="423"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="620"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="697"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="919"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU16932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117596" checksum="1309F392A69ED2CA" modified="2017-10-25" version="1">MPGLIAVSDFIDETRGDYNSPTTSTFVSRMPQCRQTIAALEETLDFDREGLTKLKKAIKAIYNSGNAHVDNEMYLGRALERLGDAALKEQEPDIGAAFLKFAVVTKELSALMKTLMQNISNIVMFPLDSVLKGDLKGVKGDLKRPFDKAWKDYEAKYAKIEKEKKQHAKEAGLIRTEITAAEVADEMEKERRLFQLQMCEYLMKVNEIKTKKGIELLQHLVEYYHAQTNYFQDGLKTIEHFGSYVVDLSMKLQKIRQAQDEERRRLMELRNLLRSSGCDKELNTNTSSGYSLHQLQGDKQHGVTRTGHLLKKSEGKMRRVWQKRRCSVQAEGYLDICHADENKPPTRVNLLTCQIKLVPDDKRSFDLISYNRTYHFQAEDEADQRAWMSVLVNCKERALLRAFDASGKPEANHGNPSLVELQQAVIRCVMRLPGNDKCCDCSSQNDATWLSTNFGIIVCIECSGIHRDLGVHISRIQSLTLDNIGTSQLLLARYMTNQAFNEVMEAMLRHNFKPSPTSTMEERYEFIRAKYVEKKYITRTCVNEQDLLSDLEHAVNNRDLHHLLQVYAENVDLSASLPTSDLCETALHLAILREMGNSLHIVDFLIQNMPTGTIDKTTTEGDTALHLSAKHDKAEAMKLLLKSGADPSLRNKQGKTPLDIAQEVGHHTCQELLNHAMQRQKTLFDNVNIDWNLSHDEASTDFSDDETIIEERNGCSTPEKKLRSRPPSYAGGTESGVTDSPVTLRSRSSTCDSLQSGLSPGFCTSKEQMPPPPPPQIKKPVIVPTPVVPDVSSMNFHGSLKKRVAPPPPAGLDSSTTSGGAVGGLPGSILSPHYGTLPTASHSRTTSEPILTSHTTIQTLPYALRTLNTTTQNHKRSPSGDSSTGHGPDELLKYPVIVTTMYYTVDLVSFGIDKIGMNTSTLQRPRNPPPPAPPTVSSTTSSRVSDDPANESLVGETGGLGNPLPPPRKTFCLLLYSPRKNPPASATGYSGLRRCRALYDCEADNEDELSFHEGDVIVVTNEHTDDDNWMEGFLERAPERRGMIPISFVHMLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF72</accession>
    <name>A0A232EF72_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005097">
        <property type="protein sequence ID" value="OXU17001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF72"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="212" mass="24282" checksum="5A699202F5D78F7F" modified="2017-10-25" version="1" fragment="single">NHHASTFESAAGTDKDEEDVEEFDTICDDIEKSDTFYRNSPYYVEFNKIMTDEQTIAIKRNDKDFSAKEINPFYAPDFMEKVITKWMPYAILWSSLDLDIFAPGISRVSNAYVESSNKTMKELVLKGYSQSSIGNVVRALKTDQESTRALIAVNEKLTGSKKSRKRPLYPTVESEKKDASRETKSRNTVEQSQFKSEADEISAERKSNKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFE5</accession>
    <name>A0A232EFE5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aminopeptidase</fullName>
            <ecNumber evidence="17">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_013919</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="17"/>
    <dbReference type="EMBL" id="NNAY01005063">
        <property type="protein sequence ID" value="OXU17048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFE5"/>
    <dbReference type="STRING" id="543379.A0A232EFE5"/>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 17" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="20">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="18">
        <location>
            <begin position="237"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="19">
        <location>
            <begin position="537"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU17048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="874" mass="100403" checksum="928AA99979C9F8EB" modified="2017-10-25" version="1">MDHENVGMAQFHRLPKTVQPVNYDISIVPNLETFVYTGKEKITVNVFKSTKSIKLNSIDLLIRNVTFNSGNKYEILSSDNIVYNNSDETVTINFEKDLPVENGGILEFDFDGIINEKLNGFYRSKYVSNGVTKFAAVTQFAPTDARRCFPCWDEPAIKATFDITLTVSKGLQAISNMVIKSIKDDLNMITITFERTPIMSTYLVAFMVCDYSFLKKQLNDKIIRLYAPKDRIKDGEFSLDVAAKALSFYESYFNISYPLSKLDMITVADISFGAMENWGLVTYREAVLLVDSENSSIVNKQKVALTVAHELAHQWFGNLVTMEWWTDLWLNEGYASFMQYLSIDHLYPEYNIWIQFLMSTFIKALELDALANTHPIEVPVENPSEITEIFDQISYSKGASIIRMIHNYIGADDFQKGMTLYLNRHAYSNVQTEDLWNALEETSNKPINKIMSTWTKLPGFPLVSVTENDTNDDSKNRIFIFSQERFYINGSVDNTNTTWMIPITLSTAPNPEKVFKVIILDKKSKVIEIEDVPKNAWIKVNVGTVGFFRTLYSRELLKKLLIAIREQSLPASDRLGLLDDLFVIVQSGRKSTAEYLKLLKEFENEKEYIVWSSILNNLRKINNILSNESNINNKFKKFGRIFLSQIYSKLGWTPKPTENHLQTLLRLLVLSQLVEFEDASVISEAQRRFQMHVEKKSILPADFRSLVYRAVLSVGNSETYEKMLSLYRETSMHEEKNRILSALGSIKDVNILQKILEFSMSEEVRAQDALQAIASVTKSHQGKQLAWQYFKNNCQTFIKRYQSGTLLTRIVETITESFVAEEVIEDIQGFFKNNPVSGTERTVRQSIEIIRFNVAWLNRDKEAIEEFLNLNKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFJ6</accession>
    <name>A0A232EFJ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005023">
        <property type="protein sequence ID" value="OXU17094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFJ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="211" mass="25320" checksum="965CF34E3AE10D21" modified="2017-10-25" version="1">MGIYNNIDSYRKMEVLLQRGPSLYPIEKNVHFICNEFLPWNTPKIFIPLLAKGKVENQNINIEDELTLKECYPTLYDKYEKACLEWQLISRQNFIARVTFKQLIERPTILFLHIAKTCAFQNRQKEIYPYQFPIYGSQITQAIQQMINKRIIWKEHEERLQEITYESIPDLIIEQQISLTPRLFLSHRWQQFGKIWCIRGSHSSSRHIDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFK7</accession>
    <name>A0A232EFK7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004999">
        <property type="protein sequence ID" value="OXU17127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFK7"/>
    <dbReference type="STRING" id="543379.A0A232EFK7"/>
    <dbReference type="OrthoDB" id="7699665at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13307" checksum="FDE236C4CEC3D5C6" modified="2017-10-25" version="1">MHVEVFNGEASGGVLFGSVMDSKPVSILSSKYGNEPKVEMQRWQESSKKSILFPHCFSMYNQHMGGVDLHDQHCNALMPTIRSKKWTWCLVLRLIQASLANATVDLKSSTTSRLCTDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFU4</accession>
    <name>A0A232EFU4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004932">
        <property type="protein sequence ID" value="OXU17217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFU4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="11324" checksum="D7AB9CCA36F876BA" modified="2017-10-25" version="1">MASALSIFGYYKLPVPTVDDLTELDILEVRRYLAVMMEKEWQLSFSQSRDSSIQDNNAPVEQESWPYNKGGYLQPKDLDPIDWWFYKDLKDIPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFX0</accession>
    <name>A0A232EFX0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004932">
        <property type="protein sequence ID" value="OXU17218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFX0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="9613" checksum="A2FE9CAF1CEFE47B" modified="2017-10-25" version="1">MKNRTPARKATISNGDLPIRLAYANQHRLRTEAEWRRTVAIDEKGDAQFGGLMAHATSLSMLYPREKAAGTLDRIGLGYLVMAREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGL1</accession>
    <name>A0A232EGL1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004745">
        <property type="protein sequence ID" value="OXU17481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGL1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="997" mass="112119" checksum="AF96DB28D7CA5A0C" modified="2017-10-25" version="1">MPFDSDAVEYNVLHKKKTKKKQNAEMDNKAVSSETLKENKDPLVNPVQNNCIEENLEKSIRSDLLQEFRNARLLEKWTGDIKYEGLFDYWLSINKDYTVCNKVKPAVKSVSTLNNHKQLQSKISIALISKQATISNVNNESVDEGIYSIDSNEIAIEPYNSVPEETINVIYITTEDQTLDCYNEQMPYSNEYKDDKLELTNNLSSEDSVVSLVLEENVQKKDDTNQAQRTTDCPNSINNILEKSDVQIDKENISINQNEADASSSFSQIFTMPTEFLPKKKKAKLGKSGKPKTPAASTLEGWADIFNEKEKSRKLKEERLSHTNGTLFERANRLLRRLQGNYTAEDFIQDSDLEDDIAKRDDLCMTFVQSPSFPEELRKDVLTVIKVEEALENSLQGNAQLRSSSPHDHQKAQNMSLTITVDSRLHMRGEQHLISFKELQMPTVLNTGTPNSLAPSHAATTAVTTKIKSVPTGAHYSRSAGAPVTVTSTTPQGTSKTSQNRDVPLVRTVLPNGCRSYRTAKGFDSKRQFNKRSSTKLNNVVSNAQQQVAEDTLRNKVNGSAKSVQFQDTLDLNYYVISKLNLDETKPLNAHAPIFHSTAKDYCPNAPRAARTSLPRSLYAGAPQHPKVCLPATTICSQPVCSSWNGGIWPPPIKNSLSHLNPCATYPTTEVSPSGTWHKSSVRKPRTSLKFSCDKGVSIKEFLDQFEENRRLDNIPDEELLDSMVPMFEKPALFWFRTLRPSWQMYQDFKRAALNNYSRTKRNKWSLVIEAHLRTQGADESVRDYIYSLPPYRFKLIRPAMASARPAYRSKLTNTQEHLDKAQEAEDDEDIQWRPPPPGDQSMLPEIAYRPAVKTAKPKPVSVTSMDTKLSSLTEEDLEKHFEKFFQKKTQELGSPSCNTSGSENKAPSTKAETPPKQGTVDSNRVSTRGGGRGRGGRRGRGGWQRGGNRTERITPKSDKNKDQTAGPDGNKVLCWDCSWPGYTKFTCPECAKKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH23</accession>
    <name>A0A232EH23_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004613">
        <property type="protein sequence ID" value="OXU17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EH23"/>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053255">
        <property type="entry name" value="EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24047:SF29">
        <property type="entry name" value="EATER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24047">
        <property type="entry name" value="FI01909P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263211" description="EGF-like domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1568"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4 5">
        <location>
            <begin position="1460"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1631" mass="178459" checksum="3D408FA58B748994" modified="2017-10-25" version="1">MMLDRRLVFLLFYSTLASCILAQANNANLDYASFPANENGTCYKRVPYDEALAVNISRGIVKTPPGSQQAGVKTNSNRGWLTIIDCCEGFIRNKSTGKCETHCDEGCFGGTCTGPNVCTCEDGWRPEAGVCKPICRRGCADNAYCFSPDICTCKFGYEEEEGICKPVCRYGCRNGQCVAPRDCRCNPGYYLNETQRCEPVCEGGCPHGRCVQPGICECNRGYTNPENDPETCTPSCPDTCTSTNGRCHSPNVCTCDPGYTQTPSGTCIPECLGDCPNGRCVAPEQCECNQGFVMNRQLRRCVEGQNGRDGYYENPAVNRSRGNNYDNPTIPPETTYGGRGTYRPEDSSQLRGPDQGLKRPQNYDVQQPGRAYGTQGIVQNRNRPDSEQEDMYGTTGQYEDAVALNQTQNNSRVIGLKGGVNRQNIPGTYPTSENNNRYTGYRNNSTGGIHRPANSQGPFAPLEPYDPDGQRLNQTNPRDRNPQYETYGNSQTPRPLRPVNQQGPFPSQGPYPSQGYYNETHGSDGRYYGDRRNNQTRRPYQGPYGSQGPYPGQGPYSTPAPGQGLYPKLPPIPGQDPYAEGPYSGQGPHPTQETFPGQGPYSTPAPGQGLYPKLPRIPGQGPVSTHDPRDFESPYGPQYNGPTPDPLGAHGQNPSQRLPGNNQPYQPLGPYGIPARGQPGNPHETLGLKGGRRPWPDSSRNPGVDIAYGVNEMQNLPQNGNVNPRPGQTSVIVGLYDPYNPVAPGNDGTDNIYVLDPSMNHGFFNPYLPPGSPPQLDPGFAPFKLPGYSHYRPTCDSPCVNSVCVGNNVCQCKPGYEPDPINPNGFKCVPSCPGGCVNGVCSGPDLCICNAGFVKERGGFSRCHHSVLSSVSRWPVSEQQNMEFSAIVLFVLAVIARTESVYRFSDFVIHRNCTEVFSITTPKYVPYEESYRTRNWLGFTKWKTRTNYRIENHVSYQRRSVCCSGYTNYGSSMCIPICSKSCGSYGVCSEPETCKCFQGYSMDHSINDCRPVCSNECVNGKCTAPNTCVCNNGFHKLSDGYTCTATCNTCTSLELCVEPHICRCKPGYRRSSLDRLDWIKEASPCEPICDKPCVNADCVSPNVCKCHEGYEDLDDDVYTCEPRCSHGCGLDGYCTAPETCTCRPGYALSHPGSNICIPICTDECVNGNCVAPDRCNCKDGYAKTGSDFSHICHPVCNSRCTNGYCSEPNKCICLPGYAASNDYQTCEPVCKEPCHMGTCTAPDTCTCHKGYKLSEHSNFTCEPHCDSGCDHGLCSDPNKCICYPGYAATNEFQTCEPVCKEDCHMGTCTAPDTCTCHESYRLSEDNNFACEPICSLDCINGNCTAPNECTCDDGYEMKNGSSNNCIVICECQNGFCNDDSSTCKACSEGFDLTVVEGNSTLCQPHCEGNCSSHGQCVEPQSCDCDENYVADNDTLGNPVCLHACGGDCQHGTCEVGTGLCSCYYGWAGKFCEEAIACVLRIYNDTKISLRPSEWDGYDDSGNWTVKEDPWTGPTCHERCLHAMDNSTKCLNQTDVEANDWLTCYMSIESSCNTHSVVMANLYKSDVNVVTIIASCAIMLLTLATVVSATLIFKKKKRNQRRDTIAMTSSEQEQPEAEEDRLIENDTDGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH45</accession>
    <name>A0A232EH45_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004633">
        <property type="protein sequence ID" value="OXU17632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH45"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="111" mass="13215" checksum="0E50E5A62F9E5B50" modified="2017-10-25" version="1">MAISPRKYPEKWVVNNDRPLYCFSYHLQFKITTKQADFRSIVNLLKTNRAAHWENRAPRVKRKRSDDRYAFPPTTRETVVRKPKIKILRPVREGRLTFAFRVTDKAVGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIA1</accession>
    <name>A0A232EIA1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004307">
        <property type="protein sequence ID" value="OXU18075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIA1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="61" mass="7215" checksum="AB7F347097E19CFC" modified="2017-10-25" version="1">MRRQYAKTLSKSRSKKVRKPSLVFKRVTFDRLKALSKIIDHRIKYLLKVKEAITIIVKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIF5</accession>
    <name>A0A232EIF5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004278">
        <property type="protein sequence ID" value="OXU18114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIF5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="127" mass="14653" checksum="F4F1A46565C62FFC" modified="2017-10-25" version="1" fragment="single">MAAPTNFFGFLRPPRIRKTLGSKHLKAPIFYRASVQILLGEFNTGKMIENKPRFNFTHLVYEGAIQNRIEVSEESCNLRAARFCVFFNYPIDGNNSSNMHLRENKITYFSLFGPQDRPLCTANKMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIH9</accession>
    <name>A0A232EIH9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004233">
        <property type="protein sequence ID" value="OXU18166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIH9"/>
    <dbReference type="STRING" id="543379.A0A232EIH9"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="338"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU18166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="695" mass="77912" checksum="144010302A5486D7" modified="2017-10-25" version="1">MSDNVVKFAKLRCTPESSFWAKFAELKIDKFKLEDKIKIPLWGSYSLGLEEKGGRPLFLDYTSFNEDLEMTSHNSAVPCAGYMINTNTFETFRQTNPETFINTLGKELLDLLKTETAVKEPWRLMTFLLLCYSDLKKYRFHYWAAHPTPFNLPEMHYAKQQVFIREEFTADQVQSFEEGFRKLDAKSRSFFSVIISKESKTLEIVSLARGIAIGNSSDKENEANIYFAFYDPCSHTCPGWPLRNLLCLLFLQCPNVCFEKWMKFISVRGHNVTNSVVYTIRTKEQENREVLNESLLGGNLVGWESNARGKMGPNIADLSETMDPVKLSDRAISLNLKLMKWRLVPELDLDYISGMRCLLLGAGTLGCSVARVLLGWGVHTITFVDNSVVSPSNTVRQNLYTHEDAVNRRPKAEAAKNALLKIHPNLNAQGVVLQIPMPGHVVGQSMLESTKQALAKLEDLYSRHDVVFLLLDSREARWLPTVMCAAYGKMAINAALGFDSYTVQRHGTRIDCDSAASPDLTVQNPGGKDLGCYFCNDVTQPGNSQVDRTLDQQCTVSRPGLSYIAAGLAVELLVALTQHPDKAEARALMDDGKEQGRSSRESSGMMGLLGGVPHTVRGSLWSHETRLTITHRFPSCTACSLPVINEYRARGADFVLDACNQPNYLERLAGLEDLLKRPDLDELCYALDTSDEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ43</accession>
    <name>A0A232EJ43_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004120">
        <property type="protein sequence ID" value="OXU18342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ43"/>
    <dbReference type="OrthoDB" id="7633179at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="627" mass="67591" checksum="C4E94FC14B02EAD7" modified="2017-10-25" version="1">MAHVSCWVYSVTPPVAIDSVIHSPIHMCITYARVCAESKRRREFRKRRNRCAEASVMSRSSAPVLPTARLLLSLLLIDASSAQTVLDIGCRAQSCATLDVALLQEYVTGLRQLNDTDQRPRDELSADELRLLPFGALDSDWERLMLLQDSQPEGTALRDNLLRLSRLVLAAYFHSQDLGVPGEKTDSSPVPEAEDQQASNATLGSAAQNSGSARIDASPSQSDSAAYNNGEETSASSEKFAGNDEEDPTATTSYYADSTSANFNQAFSTPASLDNEASGSKSNETSLAAAAADNEDESTRETWPESFSHSPSPALERVSSSPESNEAVHPRSEEDFLLSRYASKEARREDDELVAKFFAEEHDDSNDSMEDLLALMELEEAELLANQSTSESPLLTSADDNDSFEFNATRSLEALLDAMEGLNESSSASPDDPELTSSQELLELIDGLSAEDNPTTPLLQMISGKLSAETASYSNEASTTDSGENGRTDRSEEYSDTTFPSLSPTTDKASSENHTRELEETPTTTVDALPADWALTLTIDATPSSYGANSEPRQPGKILAIFRHSQAAGASSSNSSSNKLTWPTEVASSEEESASLNPTSSEKGMDRQPEIAGMNKRKRGGGGEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ58</accession>
    <name>A0A232EJ58_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein cornichon homolog 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004085">
        <property type="protein sequence ID" value="OXU18396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ58"/>
    <dbReference type="STRING" id="543379.A0A232EJ58"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="16162" checksum="6F5E5ED906FFB2BF" modified="2017-10-25" version="1">MLLKTECAQCQCFFYSQQWVIPKMLAHTILLILLLINTQWILSLVNAPMTMWLLYEIFTTPRGNMGVYDPTEIHNRGQLKRHMRDCMIYLGYYLVFFFIYLYCVLINQLQLSLFSLIVSLLKGDPINRHEDDNVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJU6</accession>
    <name>A0A232EJU6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003936">
        <property type="protein sequence ID" value="OXU18626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJU6"/>
    <dbReference type="OrthoDB" id="8046116at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9339" checksum="38441BE73812925F" modified="2017-10-25" version="1">MMQERNCFFLPIFLLPHSNAEPERTFSDVNEVKDLKGNKTSTAFLNARCFLRSYNAPYNINSLTFKTPKKQLNMFTTENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJZ9</accession>
    <name>A0A232EJZ9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003902">
        <property type="protein sequence ID" value="OXU18686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJZ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="48" mass="5314" checksum="41221EBAA796B570" modified="2017-10-25" version="1">MLTIILLDSGRVPSPLGVDFAQILQDILDTQHKTHQTLHKYGANFLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKD8</accession>
    <name>A0A232EKD8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003813">
        <property type="protein sequence ID" value="OXU18813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKD8"/>
    <dbReference type="STRING" id="543379.A0A232EKD8"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000587">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="1">
        <location>
            <begin position="90"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="261" mass="30212" checksum="36EA4A6A77D9A301" modified="2017-10-25" version="1">MLLVSLASRRVSSVDNIFNGTNKIKISPNLYFKIRYKSDDVVVKINDISKKIKSPKNPEYVPRKYLLKNPNQETLRHLRWMLQKDILGQDMFLMGAPGLRRRNLAMAFLELTEREVEVIALSRDTTEADLKQRKEIQSGTAHYHDQSALRAATNGRILILEGIEKAERNVLPILNNLLENREMHLEDGRFLIPASRYDKLLKEHSQEELDTWRLVRVSEDFRVIALGIPAPRYPGHPLDPPLRSRFQARHISPPNYEVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKM9</accession>
    <name>A0A232EKM9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003740">
        <property type="protein sequence ID" value="OXU18916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKM9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013212061" evidence="1">
        <location>
            <begin position="31"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="429" mass="49412" checksum="5538B01314D22364" modified="2017-10-25" version="1">MSRRNLVASLVCSTCVLLFFYLEQLRGAKAVEFTKTWSTDFKNKPEIVKFNDEYLAVVVHKNLINLTSIDGIQKYACKFSIPPNRTVGLLSHPMVLGNGKLVVHVWAMDSNWIPGSKDPIGLWDLFIIFDPHDCSSTMTIEKDTNSIRYELQQVIPYHDTFDLFYREHTNRRVPSGRTSLGPRRYNDKGKRIAMIGYLLGPEQAMVDMKIGSLKRNDAFEGYFLANLRGDQKTLLLRYLDSNFREPREIKVLPRLSAFSFDESDVKDSLCYSQFEKVPNNQDSAQREKKWVLKCDFFDRKYPDQQTTVKLSDQPESHFDKSRFSVSILPDDSRVVLLEFKVSHLNGSYNYEYYLQRVYNNGTTDNERLLVATYTNDRAGQMRLVSLGEGEVCVIFMNKLETSYNVMLSILASLSDDITNVKGKCIKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKZ4</accession>
    <name>A0A232EKZ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003668">
        <property type="protein sequence ID" value="OXU19033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKZ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="222" mass="24218" checksum="FADB995DC5E9D48B" modified="2017-10-25" version="1">MMSELKTTFPQAGKATEPNPADDSDGEDHKILKGIITGTIEYAEGRSNVYGPIKTGLANALNELVKTEEKCMSFLKVPVLRLGGESLGSRTTSMESLASITSARSMDSTSLMAQIANYRKALQEAIEVRKEEEDYITKLEKKPPAKAGPSKNRSPEVILVKVGQNTTYAEVTRKIRKDVNPDTTGIKVLGVKQTRSGDILLKLGRESDRTAFTGKRKNGMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL71</accession>
    <name>A0A232EL71_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAGUK p55 subfamily member 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003619">
        <property type="protein sequence ID" value="OXU19097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL71"/>
    <dbReference type="STRING" id="543379.A0A232EL71"/>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000069">
        <property type="entry name" value="MAGUK p55 subfamily member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="8">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="244"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="332"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="6">
        <location>
            <begin position="459"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU19097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="78643" checksum="C9276C7B9750F45F" modified="2017-10-25" version="1">MVFLGRKEKRVGERDRRLLQSVDAVQQDVNKVAHYDNGTLPPGRLPRPGISLSAAVAARAPAGRRIRAVDDNRMRRAVVVAAAFMSSRDGIAPAAQQEEEDAQPEDSRTQLDRSPEPQDTDLLFLDAFIGDPLVRSLVQVQERLEHPPVHATPVCSSIVETVQQISRALEPSRNPESRELLLLLRGKHLRTLLETHDAVVAARLANGERELEESQKPENERQKPRPLLRTMPSNDDRPAEAVRIVGLRRKPDEPLGLTIQVDENGNLIIARILGGSTAASQGLLRAGEVILEVNGKQVRNPDELQIAISDAKENLTLKLAPGISADGSKPIKSTCYMRALFDYEPTEDSLLPCREIGLPFQKGDILQIVDQADPNWWQARRIEGNSLGPPGLVPSLELEERRKAFVPPEADFVHKISICGTRISKKKKRKMYQSKSNGEFDGAELLLYEEVARMPPFRRKTLALVGPRGVGRRTLKNRLINSDPDKFGTIVPFTSRPPRVLEENGKSYWFTERDSMETDIREHRYLEHGEHGGHLYGTKLDSVRELIRAGKMCVLDCSPAALKILHNSTEFMPYVIFIAAPGMEQLKSLYDLGRSTGASSRNLTVLSYFNPYYVLFAFDRQSSIRYSSRRARTLESLASLYEEDDLKSTVEESAALQRAYEKYIDLVIVNEDFDHTFRQVVAALDALASEDQWVPVNWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELU8</accession>
    <name>A0A232ELU8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003493">
        <property type="protein sequence ID" value="OXU19334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELU8"/>
    <dbReference type="SMR" id="A0A232ELU8"/>
    <dbReference type="OrthoDB" id="5914722at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU19334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="517" mass="58869" checksum="3FA3942F1E73A7B8" modified="2017-10-25" version="1">MALLFTSMWDSTMFLSTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLNHISPWIGGGDNGSESSSSSNVSNTNSTNQQNVPECKVWRNPINLFRGAEYQRFYWATNKEPLTYYDMNLSAQDHQTFFTCEGDTGKAEYEIMQTAWRERNPVVRIKAAHSALERNPDCAPAYILLAEEEATTILEAEKILKQALKVAENNYRKSQNTQHQGSIAEAIHRRDTNVLIYVKRRLAMCARKLGKLKEAVKMFRDLTKEVPPIMNVLNIHENLIEALLEMQAYADVQAVLAKYDDISLPKSATICYTAALLKARLVADKFSPDIASKRGLTTAEMSAVEAIHRAVEFNPHVPKYLLEMKPLILPPEHVLKRGDSEAIAYAFFHLPHWKQMEGALNLLHCTWEGTFRMLPYPLERGHLFYPYPTCTECADRELLPSFHDVSVYPKKELPFFILFTAGLCSFTALVALLTHQYPDTMGVVARAMLAWFSLPFHYVLDKLEAVLPSNLLQQLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMT0</accession>
    <name>A0A232EMT0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003297">
        <property type="protein sequence ID" value="OXU19664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EMT0"/>
    <dbReference type="OrthoDB" id="10003277at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057435">
        <property type="entry name" value="Lips"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37686">
        <property type="entry name" value="LD36006P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37686:SF1">
        <property type="entry name" value="LD36006P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25228">
        <property type="entry name" value="Lips"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1326" mass="150779" checksum="1D0AC68AD0453F59" modified="2017-10-25" version="1">MRRAMPHNLNNSSANAAAGNNSGDGGLQTAFGPLQSYSHRINQDDAFQPEKEPVEFDCRHLRGAPAEVEALVHSIKEVAQQFLYHWKTFPIVLPPSLSTSNAATATSGAPGSNNPQQQAEDSLARKKHQQYHLRDMFVAPSFDELDAVAVDTKGEPRRLTNKQLESIRERGLHKDKYGKPKKLNATQLESIRRCGEFEVDSINFAGQTHRWRLSGLLQRGRDRRRDALLKDLALATRFIVVTAKGRLVSHCFSVSESLKALLTGLLRLLDITIGVPSLQAQNLDAKISEERCRYLVAELVCRNYYRSSNPLRQPEYEDSLELLCGFIRRQLQRATMEKFEVERESQMLPVPVPFVFGTPGGAAVDLRLFNRAIIRKALPTLIVILERETRGWFLHFREKLISELRAQKKSDEEIEREVNEAVMREYLQRVYSSILSHPDIVALGEGIPQLLIQQAQSVLLMHRAVENVQRKLARTKEALRERIERDHPVLSRIGPWMRDRMREAEAKFIQECEWSAHEEALALCSQQNLQQTLYFLNRDLTFMREREPVLLKELRKVKTPTRSFQWPTQIWLPRNWIVKRSFQGQSEIIPTVLSNTPTSITTPRADPSQPVFFVEREIVHTTTTRWPMWRWINYVSRTWCWTWNAMFLFGVALPWCSPVSLRALLLMHPFTPDLELSQLNGTLFPRKSSQTPTLYSRLTTLWRHISKSRTHFETEPDTGFIGKGMTRHINRLWNYGAKGLLGTMVILFLFPVACILISCASLFIALTAFMWMPMVTLALHAFMALIMDLDSPESSRNRYLVVIEALVWNIGIQGCLQPIAALLVAAVVCPLVSFMILTVAVIRYWIRVMWDTLMFHLVIKSRGRIPASDSFVVKRIAGPGLASDYYYQIRPEQALAAFEAKLELDELLAFQQEMERLITQPQRDFTQFVEACFGPFAATLEKTKEPYKSLEKEARDLIAALHEKLDRRRKDLQTGLGVMVRSKIKLSTYDLKVVIQQAALMLERFYPTHVFSRMSSTEDDFWENKGLGVGDWAGLAGLMYADIFSLDFLQPLDDADTKFKLEPHPAVNLSRYTDMVHNTELGGGVNGPDLLGAVYAPRGNIQVHSPHLAVTTFHPRATFKNQNNSRKADKPNDTIGLLTSTRIRRRTMTNNGGGTGEGRWQPWKRQMRPYSAEKLMIPLPIPHPAHIAVTIHNRDTEDPIPLDSEICQEILRAIEESPGEMAMESVVVGRYRGGDSSFDSVASQSSISIEASLDKIEEAAQQAQEDDTADDKETETYHWTLSNWGGGMARRRNNSGSIKVDLASPEDVTLDTDSTRVMFSTYGTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENE1</accession>
    <name>A0A232ENE1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">No mechanoreceptor potential B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003168">
        <property type="protein sequence ID" value="OXU19875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENE1"/>
    <dbReference type="STRING" id="543379.A0A232ENE1"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="90978" checksum="FFB081B413ACEE88" modified="2017-10-25" version="1">MTAVDRNDIYSGYHDFSNTYSTADLDQEEFFREVLKTGYGARPIATPKYPGTGMRLGTSSGFHRGSTASGRPGTGALRPMTAVRGAGYTSASRQAFDPLNMSSALRNFPLEAEKEDTPEEKIKQAERRIMTLIEESAKAACEKNMKVALERAREASSRERALIRLQEQAGLSDSHNIDLTFAVIFNLACQYSNNELYTEAIATYQAITRNRNFTNSARLKMNIGNIYVKMGQLSQAIKMYQMALDQTTTAQKYLRIKIMHNIGMLFVQMGRLEEAANSFEWVMREKPDLKAGMHAILCHFALSHEDKMKKAFLELLDVPLYIDHDDKYSINTDDIAANILNETVKNDDLSKLERELKSSAEKTILNAANLIAPVIEETLAGGFAWCVDAIKSSAYSPLAANLEINKAMVFLHNREVRMAIDSLKVFENQDTKINSSASSVLSFIHFLRGEYDQAEKYGEAAKNADSRNAAAYVNLSACAIMKNELDNAKEYLTSALENDAAHVQALYNLGLLYKKKNMLDEALEYFLKLTNIVRYDPLTLYQIGHIYQLSNDVEQAADWYNQLLGIIPSDPGVLQKLGEMFDSMGDKQQAYQYYSDSYRFYPANFDVIDWLGSYFAQQSGLPEKALTYFQEAVVLAPEEPKWRLCVASCLRKTGQFHKALAEYQDINRRFPDNIECLKFLVRLSNDLGLKEAQTYAIELRRAEKAKETKERHGSGRPGSRRSNSGTSSRGGSGMSTLSEQRASPTLHNGDIVRSNHRLLRADSSEFNLDSSSHDLNYADPVGLLPTRPMTAAGKRDDDFGDEVLGEDLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPD2</accession>
    <name>A0A232EPD2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002977">
        <property type="protein sequence ID" value="OXU20192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPD2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8125" checksum="740D024DF9DA7649" modified="2017-10-25" version="1">MIYWPSKVLMQTGIDLFRIVRDLTTENSHKVIMGDLNADLTSASDDASVIRRLTKALSLRIVQYGPTHHNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPY1</accession>
    <name>A0A232EPY1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002887">
        <property type="protein sequence ID" value="OXU20382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPY1"/>
    <dbReference type="STRING" id="543379.A0A232EPY1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="18240" checksum="B8D3AAB500BFB9AC" modified="2017-10-25" version="1">MSRTKNIKKFNCLKSLEKPNSDIFQEDALTFNDSVQDKKIIKCSLDLKLSRTVSASSDSNASRSLTNSPQISPGLEANPGIALDKKKQVTSDYYDLRSLTTNSESMYCQPSEGSAFHTISKDNLASLHPSLGVSNTQNNIHTLQLQWLARTGMLYPQLPADITDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQF3</accession>
    <name>A0A232EQF3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002760">
        <property type="protein sequence ID" value="OXU20619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQF3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="10836" checksum="67FB8E7021CEE5C9" modified="2017-10-25" version="1" fragment="single">QEFDGVLSFLPEYNKAVASFLHRITFGIRCTSAAQPGGSTSTTTLAEGACDRSSDSLHVIHGASSPSLSLSALCVSPPPSLPQRAYVSSSDVCIARCVFLSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQJ9</accession>
    <name>A0A232EQJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002776">
        <property type="protein sequence ID" value="OXU20576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQJ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059408" description="Saposin B-type domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10559" checksum="AEA00D9937B2920F" modified="2017-10-25" version="1">MMKIALFLAVGLVAVFNSPVNAELTEEDGQKLLDAIKDEVAKQSLQCAGVESYCSHDVPNEIPATLCPNLLKAYLCDNVNSAAGINQVLVDIAKRAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQT3</accession>
    <name>A0A232EQT3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002723">
        <property type="protein sequence ID" value="OXU20692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQT3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="9976" checksum="5052C9C368203A14" modified="2017-10-25" version="1">MTFSHKLTPRTDALILVKRRRKLGPAKTKALSRGLPKGLEAVRMLLYIYSYTQAVRCPRERLPSLDSLTKSLTLKIREVKLLEAVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQY3</accession>
    <name>A0A232EQY3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002687">
        <property type="protein sequence ID" value="OXU20773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQY3"/>
    <dbReference type="STRING" id="543379.A0A232EQY3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="75"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU20773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="681" mass="75962" checksum="623ACDD996B37EE5" modified="2017-10-25" version="1">MDPSSHASSHQSVPGRRARIMRLHYNTRTRPRRLLLLLLLVVNVFLLAFEVEAQRTHARQGGSNQRDLLTVRLPSQGTIVGKEVFLSRTQRVIQYLGIPYAQPPIGQLRFSAPVTDPLPSWTGVRNATVFGPSCPQISERRKLHERNFLKLLPQNLPNPGLSEDCLFLNIFVPDSNRPAEGWPVMVWFHGGDFNGGTPAIWDASVFVTKQKVKSDACLLIDSRLYALQVLVVTVAYRLNILGFFTTTDAEAPGNYGMLDQIAALDWVKRYIELFDGSPKNIVIYGHSAGAISVSLHMMSPLSRAKFSKAIAMSGDAINSVRTPQEELPVVDQVAYKFGCLRKTSELMECLRNKDLDTLIRESAFIETWGPIVDAETNNSTEGPFLPKHPRDVGDDDFYSVPLIAGYTNNEQALAFVELLGSEHDDGRLKMQQFESFIRDEINAAVVAPDENSTCELRPELVSEAVTFFYKPHPPTKDARVLRDRYLDLQTEKNYAAGLIQLAAKVSSHPSQTKAFVYRFDYRARTPSVSGDVPEWAGVPHLLEQPFVWGLPYATGTNTQWNAADKKMSDMMMSMFSTFARTGNPSLNTIKWEPHTEINPGILIIERNIDMSDPGAVDFKALAFWNEYYPVLLEAATNNCCNVTSGAISLTGLMGEFLPRSTGFIVTAIVTALKYFADQGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER39</accession>
    <name>A0A232ER39_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyl-CpG-binding domain protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002675">
        <property type="protein sequence ID" value="OXU20801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER39"/>
    <dbReference type="STRING" id="543379.A0A232ER39"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032343">
        <property type="entry name" value="MBD2/MBD3_p55-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025884">
        <property type="entry name" value="MeCpG-bd_2/3_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396:SF0">
        <property type="entry name" value="METHYL-CPG BINDING DOMAIN PROTEIN-LIKE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14048">
        <property type="entry name" value="MBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16564">
        <property type="entry name" value="MBDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyl-CpG-binding" evidence="4">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-CpG-binding" evidence="4">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-CpG binding protein 2/3 C-terminal" evidence="3">
        <location>
            <begin position="129"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU20801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25500" checksum="363DE9B89B4DDF36" modified="2017-10-25" version="1">MNMSVEKKKYSSALPTNWPTREEQPPRKSQNQQQLTSTGKVDVFYYSRGVRNDASLVPPIRQTASIFKQPVTIYKTQEGKVKDIKHGNQEKPKQEGADKTDSKYGSRDKPKQLFWEKRLEGLRACDPDGYEFDGMDLPKSLRPVGPYITEETLLQSVATALHVSTQPVTGQTGSKSSLEKNPGVFLNPEQPLVQAVSITDEDIKRQEERVASARKKLQEALRSMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET48</accession>
    <name>A0A232ET48_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_013811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002332">
        <property type="protein sequence ID" value="OXU21531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET48"/>
    <dbReference type="STRING" id="543379.A0A232ET48"/>
    <dbReference type="OrthoDB" id="7700243at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="202" mass="22621" checksum="F51A1D60893A01D3" modified="2017-10-25" version="1">MKQVVNYKSVLLKTIRKILIENGTNSDGLTVSKQPVVQIDSKNFDTYSEDSFTFMQPTDRVHKKITSSNLSIQVITSNELKFMNKILGKGGQGTVFKIACALSYLHLQPVPIIHRNIKPNNVLVNENLLVKICDLGLANSKAIDESLQSTRNSIQGTYLFMEPEILMGREKATTQSDVWSFACTITSLYIESPIWDMDGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET90</accession>
    <name>A0A232ET90_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002304">
        <property type="protein sequence ID" value="OXU21575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET90"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="387" mass="45352" checksum="BE4287DA98B15738" modified="2017-10-25" version="1">MTPSEYRERQLANLSTNYEPPHLNTTTTYRKLKEEAVNDLLGYSQYKKQSITNSHFLNYCNVKKLDLEPFNIYYWSERQVEFWNSIQHKRLPLSFDATGSLVKKYSFYKDLDKSKLDVAHLLNTVRHWDCFDKIDPSIIDFYLRSVGYLTQVETLESFLDIVESTYEQQLNKFNADASFLESDEINENNKKKESKKGADNSLILFINNLFGKVVELCPQKFTKPFKTLCYTFPSWTYVMRNLFESPNIVATSTRSETFFKWRKAVITNPIIAQKFLLKEKTKTDGLINFGFTKLTSTDISKKKSIFNEVYELDIDLEKLQISNEINIGENSENMLMLQKSPVDDGLEFHSTQITNDIEEINYFRDQNMLQVSDTIDDDLETYELPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETT6</accession>
    <name>A0A232ETT6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Venom dipeptidyl peptidase 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002223">
        <property type="protein sequence ID" value="OXU21775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETT6"/>
    <dbReference type="STRING" id="543379.A0A232ETT6"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF154">
        <property type="entry name" value="VENOM DIPEPTIDYL PEPTIDASE 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646940" description="Venom dipeptidyl peptidase 4" evidence="7">
        <location>
            <begin position="21"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="9">
        <location>
            <begin position="106"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="568"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="774" mass="87307" checksum="C8B9391D8162CDB4" modified="2017-10-25" version="1">MVRAEILGLLCLQLIISTSGRTLDDQAKADTIRTPAPKEKKVFSLDDVISNAYTSDSFNGSWISETEIFYRIEEALLKFDVTTKQSEIIAKDGLFDDVSGLKFYLSPDRNYVLIRNLTEKVYRHSSLSVYSIYTIKNRSVSVLADGKRLSTAFWAPQGSALVYVLDNDIYYHQLASYGVETRRITFDGKQQAVYNGVPDWVYEEEVLGTDRAMWFSPNGEHLAFATMNDTEVVEAVIVKYGRPGDLKNQYTYEEKFRYPKPGTKNPQVTLNLVDLTDHGSSLISLKAPTDIVGNEPILYAVTWFDRKTVVATWTNRLQNVSQLASYSLAGQWQPLLTQEVTDGWLLSAYTGASPIYYKGYVFLVEPQPIGNKSLGEFGHVTSYRLLNGVLDHELDLTPGATWVHALHGVNDVKRVLYYTASPPGQPSQKQLYEVSLDASKDVPATPKCLSCELKTPEGNTCKYVSSVAFSKDFSNYVLTCSGPDPATVRIYDLEGKELFTWADSRVLRLMIANRVLPQQRNLEVESNGFNARVRLLLPQDFDPAKKYPMLVNVYAGPDSQRINDGFSVGFETYMSTNRHVIHAWIDGRGSSSKGTAMIYAVYRNLGSAEMEDQINVSRKLQKMFPWIDKNKTAIWGWSYGGYSTASILTKDDDSVFKCGISVAPVTNWIYYDSIYTERFMGLPTASDNLKNYQASGVMSRVEKLRGKKFMLVHGTGDDNVHYQQSMALSRALAEADILYDQVSYPDEAHHLGHVTKHLYHTMDKFWSECFGYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUX7</accession>
    <name>A0A232EUX7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002077">
        <property type="protein sequence ID" value="OXU22143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUX7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7178" checksum="F34DF08B31CC4675" modified="2017-10-25" version="1">MNDPGRRISLGVGLLTKETINKNSINIYGNKSSFATRGYLRSQNTNIATATLPEVPGAQGGQYHVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVB1</accession>
    <name>A0A232EVB1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002022">
        <property type="protein sequence ID" value="OXU22289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVB1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012737256" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10213" checksum="6C4D31FA3BDEFC05" modified="2017-10-25" version="1">MMSRYVCIAITLLVTISLYIENSHGLPADMTDTIGEWIEKVKPESQNPSEGLGPIISNILKPITPEKPADSIDKDKAFKGGQAKNDKMIKIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW26</accession>
    <name>A0A232EW26_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001930">
        <property type="protein sequence ID" value="OXU22521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW26"/>
    <dbReference type="SMR" id="A0A232EW26"/>
    <dbReference type="STRING" id="543379.A0A232EW26"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="34" mass="3982" checksum="78BFCFC1638DEEA5" modified="2017-10-25" version="1">MITDVQLAIFSNILGVTLFFLVFLFHYINANYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW55</accession>
    <name>A0A232EW55_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001912">
        <property type="protein sequence ID" value="OXU22584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW55"/>
    <dbReference type="STRING" id="543379.A0A232EW55"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="285" mass="32794" checksum="E6A6C080804A977B" modified="2017-10-25" version="1">MSQLLNLPTTDGNKFIVVDEGVDATYSVNLIIAWLQAIRKKGIEHPVYILLFSNPKYHLEKCLKSTNLTDIQVQDYFSTDVQDEEVDLFEQISHFVSQHINSIFVIDCLSTLALQIGVSKACKFVEKLYQKHRSQVFCIYRRDFHQNIPRMETLGNTYLKLKKSKKVAYDSNIHYEVSVIHKKPGGSISHWNELVKQNVETYSIETEKIPDSVTLKPEVNKPPEATVKPQASFRIEMNEHEMKQRDSVPLPYILPGNPGRESKIIYVPDDVDDLDEEDPDDDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWK3</accession>
    <name>A0A232EWK3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SDE2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_011326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001854">
        <property type="protein sequence ID" value="OXU22715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWK3"/>
    <dbReference type="STRING" id="543379.A0A232EWK3"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="10">
        <location>
            <begin position="70"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="262" mass="29145" checksum="5F4B783D24B2FE13" modified="2017-10-25" version="1">MLTIYLESGTHGKLKIAEVFHPASGEQLMEKINEFGIDCSNYFFKSNGRLVEFDDIVYNGDLSLEPRLCGGKGGFGSMLRAIGAQIEKTTNREACRDLSGRRLRDINEEKRLKAWIDKQSKREEEAAERKKRKLAKLCAEPKHEFKDKSYDEQRSALAERVEDAVEVGFAAASTSATKRAADESAKTNPKKKKKTILDLEDDIDSDDLDSSDESSDEKEADKKQTSNSKSDTENSSDSASSKSKPTNESPKSSSSHTDDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWR9</accession>
    <name>A0A232EWR9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001825">
        <property type="protein sequence ID" value="OXU22799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWR9"/>
    <dbReference type="STRING" id="543379.A0A232EWR9"/>
    <dbReference type="OrthoDB" id="538216at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF13">
        <property type="entry name" value="LD36653P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="262" mass="29285" checksum="40CE7890C17E0761" modified="2017-10-25" version="1">MRKKSASGTNEFQKAGRQAAYQRGNQREGSPHYVFLYSEDDQSEDEEVFSMKDKNSKPALPRKVEVINVKIQSDDTLQALALRYHCTISELKRINNIHKDNEIHAHRSIKVPVQAYSLLTETLGKSNETNQDSALDPAVSNQNEGTSSKENQLIDLLTTASTSSTIEINNIILNSTVEPLSQYNNESSQSGIDETETDQLINSIESINRQSSNDVVNTFKCSGADWGLSWFQLLCFSLLLGFLGPIIYVLYIAESSKHHHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX70</accession>
    <name>A0A232EX70_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001792">
        <property type="protein sequence ID" value="OXU22908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX70"/>
    <dbReference type="STRING" id="543379.A0A232EX70"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="23794" checksum="B320CC27CBCA90C9" modified="2017-10-25" version="1">MHKFNNPFNPKPSTPLTEEEGVTEVKKERKSVFVHNEEWDQIAIHLIGTQQRYRENIIIPRALGGGYIKSNEEKAVERFMESCAFKSIMSCVLEQEICTSKNFLGFGLGAALGLFTSSVNPNVAAVEKQQTAREILREMKTTTLGYAKNFAVIGFVFSGVECAIESYRGKSDWKNGTYAGGLTGGMIGLRAGVKAGIVGAAGFAAFSTAIDYYMHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXB5</accession>
    <name>A0A232EXB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001755">
        <property type="protein sequence ID" value="OXU23021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXB5"/>
    <dbReference type="SMR" id="A0A232EXB5"/>
    <dbReference type="STRING" id="543379.A0A232EXB5"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000899">
        <property type="entry name" value="RNA-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22392" checksum="C9D52F321CCFE8CB" modified="2017-10-25" version="1">MSRYPSDCKVYVGDLGNSATKQELEDAFSHYGPLKNVWVARNPPGFAFVEFEDARDAEDAVKALDGRTVCGRRARVELSNGERSRDRGGARRGGAGSNRPFHPEHRCYDCGERGHYARDCSRQRGGARRRRSLSRSRSRSRSRSRQRTKRSYSRSSSRSRSRSRSRNGRPAKSLSKSRSPSKSRTPRRSKSGTPHSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXM0</accession>
    <name>A0A232EXM0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001733">
        <property type="protein sequence ID" value="OXU23093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXM0"/>
    <dbReference type="STRING" id="543379.A0A232EXM0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="183"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39904" checksum="90492AC630AC5A9E" modified="2017-10-25" version="1">MCESENSTGLISVVKSTCKWEITDFYLNETVGQRLESPLFTTDEYQWQFWLYPKGYTQEHKDYMSLYIVARNASSVEMKYSLSILNQKNEKFFTLNFRKELFGPTENKGRHRFIKQELVTDVTNGLLVNNKLTILCEIVPDSTNYVEKHTEDVEPIREPEKKEEKQFVNLNKFEKLLNNQKFSDVKFVVNGGEFHAHKCILAANSEVFAVMFEHDNHEPEPYVIEIKDISCNVFIEMLRFVYTGRVNDMDRIVKNLLAAADKYAIEDLKVFCENNLCNRITTDNAVDYLNLADLYNADNLKTQAINFIISHGKEMIDKPEFKSIAHLHEDVIVQVFRNVFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXN5</accession>
    <name>A0A232EXN5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006645</name>
        <name evidence="2" type="ORF">TSAR_006646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001724">
        <property type="protein sequence ID" value="OXU23121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01001724">
        <property type="protein sequence ID" value="OXU23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXN5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7266" checksum="B393F5340C320DAB" modified="2017-10-25" version="1">MRHSVTFRATIAGQHKFCVRHDKVVVDKDKPLPFTDLQDTGCAIIYRDDACAFEKRSDKKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXV3</accession>
    <name>A0A232EXV3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_015898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001659">
        <property type="protein sequence ID" value="OXU23294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EXV3"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11428">
        <property type="entry name" value="bHLH_TS_NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF163">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="282" mass="31688" checksum="26FBFA02A3753C11" modified="2017-10-25" version="1">MLNMSSEYSYCSEGGFDEMSSSSDSGFDVSFESPKHDGPGDAMAFPQGKDEKRKKTRNARCKSPTQVLRIKRNRRIKANDRERHRMHTLNDALERLRMALPTFPEDTKLTKIETLRFAHNYIWALQQTLGSSAPGGEITLSVGNVTVSIGEGGNMISSXXXXXXXXXQKRLGPNGQPFIAGAGDYCPNGMTMPMPWPASSEYDCYSSDQSVSPPQHLQVHHPQPQHQLHIQAQPIQPQQPIPVAQHHQLPQTANHVAYSPPQACYDQRMYHFTERHDVYQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXX4</accession>
    <name>A0A232EXX4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001724">
        <property type="protein sequence ID" value="OXU23120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXX4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9380" checksum="0415E9F7BCDFC6B5" modified="2017-10-25" version="1">MYTCIFENAHLQCLDFQKFVAAGVLLLLVALTHMHFRQCVVSSRSRLPTPPPPSCARSDTDVAVANMLSSRNVLCVANILRCGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY53</accession>
    <name>A0A232EY53_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein-lysine N-methyltransferase SMYD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET and MYND domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_003697</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001628">
        <property type="protein sequence ID" value="OXU23384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY53"/>
    <dbReference type="STRING" id="543379.A0A232EY53"/>
    <dbReference type="OrthoDB" id="7770870at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="226"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="17">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU23384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="572" mass="65902" checksum="F10B6D4363C28513" modified="2017-10-25" version="1" fragment="single">MDDVRNLLLAKMKATGKSNEMTFKFKIMTTDESRVATALNIMEVFQILPQNKCKFKDSQTSINLRHEANRIFISNKNNVDKLLIAWELYSKAIAIAPNTSQELSLAYANRSAVLFCFKKFEESIRDINQALELNYPNHLKGKLLFRKIECLYFLSKVIDIKSTIQEAKCWIEDINLSINEKNKLEEKLQIMESKGALLIPLFKNENKKETIFPNIVYNKLIPCASDALDVKYSDRFGRHIITTRKINAGDILIIEKPYATMLIPEKAYTHCSQCLKVYWALIPCEFCVHAMYCSKRCKNEAWKQYHDIECAAAGYLLELDFNKCALFSMRLSILALRELGSVNNLRSNLEQINNCKSSHKDAISEEIFQSNKYHSLFTLVTNTGKRSISDLFERALNAAFILYYLCTNTALFGKKFESEISQIRTNKDATYVGGLILRNMQIIPSNIHSYEEECRINTIDIGVSAQPFCSLINHSCDPNVSRCSTGNGMLIYALVPIEPGSQIFDNYGSHYAVMNKFEREVKLKQYYFKCECRACKEDWPTYENLLPFDVSNFCINCFLRKLRLIFLMHILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY61</accession>
    <name>A0A232EY61_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001644">
        <property type="protein sequence ID" value="OXU23331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY61"/>
    <dbReference type="OrthoDB" id="5915502at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="5527" checksum="6DBDE75C36BBCCEF" modified="2017-10-25" version="1">MNNIEGSSNTEKSNLLKPINLCNLVEFYIPLSGIVSYATLSVNIMNPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYF7</accession>
    <name>A0A232EYF7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001651">
        <property type="protein sequence ID" value="OXU23317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYF7"/>
    <dbReference type="STRING" id="543379.A0A232EYF7"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="12129" checksum="46E1043D07F1B537" modified="2017-10-25" version="1">MIRHLTEDLGPLAEQLDITHMAEQEIDFHYFKLHDIDNNTKLDGLEIFNAIQHTLHDHSYEFFMLEEDDLDNDGYLAYIEFVLGRQKGQRDSIQSGWRKQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZH8</accession>
    <name>A0A232EZH8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_006514</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001516">
        <property type="protein sequence ID" value="OXU23729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZH8"/>
    <dbReference type="STRING" id="543379.A0A232EZH8"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="16">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU23729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="233" mass="26096" checksum="040A79692EB2DB62" modified="2017-10-25" version="1">MLSRGKGSDKTKSKPNSRSNRAGLQFPVDRIHRLLRKGRYANQIGAGAPVFGNYLAAVMEYLAAEILELAGNAAHDNKTRIIPRHLQFAIRTDEELNELLSGVTIAQGDLFISVADEFDDVEDDDNIELEQQEDDGENFELVAAGEASGGVQKSKRITTGYMTKYERARILGTRALQISMCAPVMVELEGETDPLQIAMKELKQRKIPIIIRRFLPDHSYEDWGIDELIIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0F8</accession>
    <name>A0A232F0F8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_009732</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cell membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the sodium channel (TC 1.A.1.10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001383">
        <property type="protein sequence ID" value="OXU24164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F0F8"/>
    <dbReference type="OrthoDB" id="2984333at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022843">
        <property type="term" value="F:voltage-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000150">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000047">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000019">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000039">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000053">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000370">
        <property type="entry name" value="Sodium channel protein 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001696">
        <property type="entry name" value="Na_channel_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044564">
        <property type="entry name" value="Na_chnl_inactivation_gate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF62">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN 60E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00170">
        <property type="entry name" value="NACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0691">RNA editing</keyword>
    <keyword evidence="10 17" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 17" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="15 17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="8 17" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="672"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="761"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1058"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1086"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1140"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1256"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1332"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1358"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1391"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1448"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1546"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="19">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="19">
        <location>
            <begin position="563"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="19">
        <location>
            <begin position="1025"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="19">
        <location>
            <begin position="1330"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent L-type calcium channel IQ-associated" evidence="20">
        <location>
            <begin position="1594"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="279"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="402"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="893"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1722"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1837"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="311"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="896"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1837"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1849"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU24164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1858" mass="214339" checksum="CED9FD427631BF4B" modified="2017-10-25" version="1" fragment="single">YIFLAIYTAEMVIKSIAKGFILNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFKQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRHMEPNATPVDWREMQSKQWHNTALIDYRHCNESYTCLCVGPNPNHGYTNFDNFLWSMLTTFQLITLDYWEDVYNKVLSACGPISVTFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERRKDLTDHREDSTFSFDPTKINIKTLTKEKQKKIDARKGVLLSSYSRKRTRRRKRGRSTVGHEKNNGNRSRSVTPSPSPSPRHSGIRPSHLPLQSALQQQQQQSPAENQQQQQQQQEQQQPQSEQQPQQQIQQQPLAPPRLPAESNVVHRLVPRNMLQSRQASNNSNQQSSMDDSGVVDDHDGDDVTSAEEHDRQHHPQREHRLQERQHLDKRRNLHQQQQQQPQQQQLVQQEKLGRGQEYPPPTPVTVSVRTSNREIRVLKCNGIKSKKHLYSLPPEYLSHIVVLDDLPDRNCDRCIQCCIDYEGWLRFQNCLYKVVRDPLFELTITLCIVLNTGFLAMEHHGMSESIRQALNIGNKVFTSIFTFECFLKLMALSKDFFNNGWNNFDLIIVSASLIDLTFELVDGLSVIRGLRLLRVLKLAQSWTTMKVLLSIIISSIGALGNLTFVLVIVIYIFAVIGMQLFSKDYTLDKFEPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAERDEGPGTCFAIFLPALVMGNFMVLNLFLALLLNSFNSEELKQKKEEVGEDSKLARSFDRIRSIVRKKKYKKEDSENEKNNKLEQIVREVMDKSEKDKYAIQETVLNLPKDNIYSRSYQESLNQPVFTYEPIYRQTAPVFSDETQKMTEETTKLQKEKEAQMKEEEKKQEKDEQDPETIEMTDEREKRPWHALVSYVDELTVGGRRDSQGNYVDAMESFPGFGKHKPPKVPQDCFPQHCYEKCACINKCLATNIGKKWVDVRTAVLSVVDTPAFEWMILVMIFASSITLCFEDIYLDDNPFLKKILYWTNLAFCVLFSIEMLLKWLALGYCKYFTSFWTILDFIIVFVSIFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCLDEQGMLLDISVVNTKEDCFRQNYTWENSKITFDHVGIAYLALFQVATFEGWMEVMEDAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPMNQILAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYNQPHPIFFVLEVSNAFFTTVFGLEAIVKIIGLRYHYFTVPWNLFDFLLVLASILGILMEDIMIDFPVSPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLALITFIYAIIGMSVFGHVRKQGALDDMVNFETFGRSMQLLFRLMTSAGWNDVLESLMVQPPDCDPTPTSRKLNGDCGYPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIRFSQLSDFIASLDPPLGISKPNVVALVSFNLPIAKGNKIHCLDILHALVKHVLGHVEESEDFKKLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQDKAARLIQRTFREYITSSGPTLGRQDAVETDEDVASPPMQPKRHSIRPSGTALSLNMLQRDIKEAFSRRCSSLRRRPAPAVPSTAQLASTITDGRDVSILVTEPSPESAAPPGRPPLLRQQSEATVVHVLVHRESEEYRDSHETLEEDREEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1D2</accession>
    <name>A0A232F1D2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_016547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001370">
        <property type="protein sequence ID" value="OXU24208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1D2"/>
    <dbReference type="STRING" id="543379.A0A232F1D2"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="246" mass="27363" checksum="BD026F55B99D78E3" modified="2017-10-25" version="1" fragment="single">VVRSSAGLFMLKGLSAFAMSTLKKPQVLFVLGGPGAGKGTVCQNIVKKYGYVHLSAGDLLREERAKPGSQYGDLIESHIKNGTIVPVEITCSLLDRAMQNSQTSHNKFLVDGFPRNADNLRGWTKEMSEKVEVNGVLFFECSEKTCTQRCLNRGAKGSGRSDDNAESLKKRHETYVNDTMPIVEHYKKEGLVYSFNGEKTPKAVFADVEETLKKIDNLKKGRKVIIETIYRLLDEYNNNALILCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1D7</accession>
    <name>A0A232F1D7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001275">
        <property type="protein sequence ID" value="OXU24525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1D7"/>
    <dbReference type="STRING" id="543379.A0A232F1D7"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="181"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="343" mass="39986" checksum="1A6D513AF345BBB4" modified="2017-10-25" version="1">MSIVARFCERSAYTLKPKISSYTVVRTVTKAKLPNTTSRGVDKDGFRILELVPKKAERVARVARKFESLPPREKQMPTDQDWPSVWPGQRTFHPASVPLPIRQGYPLKRQGPPGKYGNAELMKIPNFLHLTPPAIKRHCEALKQFCTEWPAGLEKDEDCAKHFPLEVITSDYCYSGPSIRDPLARIVSFRIKLSSLNLDTHAKDKMLRLLGDKYNPETDLITITTDRCPMRKQNYDYAEYLLTAVYHESWRKEAWEEEKTLADMEYYDWDKEQSRKNLVTIYTWPEIPQDYDYERIPHATEYKIAVADLMNNGEDDYSVTKYKEAVKKLLFLKPRNENPDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F236</accession>
    <name>A0A232F236_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_008048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001239">
        <property type="protein sequence ID" value="OXU24642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F236"/>
    <dbReference type="SMR" id="A0A232F236"/>
    <dbReference type="STRING" id="543379.A0A232F236"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007476">
        <property type="term" value="P:imaginal disc-derived wing morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="277"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38065" checksum="37939D4CA2F6F3B6" modified="2017-10-25" version="1">MSSETTSDEESSQEDLQRYEIDDLEMIRTIGTGTFGRVILCRHRGKPLALKILSMVDVIRLKQVDHVRNEITVLKEVKHPFIVNMLWSGRDEARVYMLLEFVAGGELFSYLRAAGRFSGRTSCFYAAEIVCALEYLHSKHIVYRDLKPENLLLDSQGHLKITDFGFSKKLTDRTWTLCGTPEYLAPEIIQSKGHNKAVDWWALGILIYEMLAGFPPFFDDNPFGIYEKILGGRIEWPKHMDPIAKDLVKKLLVADRTKRLGNMRQGADDVKRHRWFKLVDWSQVPLRALVPPISPRLKAPGDPSCFDDYPETDWRSQPPLPPDQLALFQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F287</accession>
    <name>A0A232F287_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001161">
        <property type="protein sequence ID" value="OXU24936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F287"/>
    <dbReference type="STRING" id="543379.A0A232F287"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000013">
        <property type="entry name" value="PaTched Related family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="797"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="269"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="905"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="908"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1017" mass="114916" checksum="46778E33CE67FBBF" modified="2017-10-25" version="1">MMLSITCVDDFLNKAFHKIGLIVGRHPAYFVIIPVILALLCFTGFQRIHYEIDPEYLFSPINGPGKTERAIVEEHFKLNYSEKFSLERITRPGRFGHVIVVPKDGNDNMLRRAVWDELRILDQLIKNTTAVHDGQAYTYDDICARWLGECQENSVLEMESIIEFVENGELNVTFPIFFNPESFTVHVLPLHFGGSIVKDDIILSVPAVQLGYFINVDSPRLDAIGAAWEEAFLNAVGEAEDTGRFKHISTARFASRTLELEFEANTQTIIPYFTSTFAVMAIFSVITCMMTDWVRSKPWLGLLGNISAALATISAFGLCCYLGIDFIGINLAAPFLMIGIGIDDTFVMLAAWRRTNIMDPVPLRMAHMLSEAAVSITITSVTDMVSFFIGIISPFPSVQIFCIYSGFAVVFTFLFHLTFFTGCVAISGYCEQKNLHSVVCCPVEPLSKSGHRSWLYRLLCTGGVDPDEPNNPIDNPEHGCMTWFRDYLAWALNRPLVKLLVIVVFGLYLSGALYGLTTIKEGLDRRRLSKDDSYSITFYEREEKYYREFPYRIQVVVSGQYDYSNKTVQKQMEELAVALENTEYTIAGQYTQSWLRTFLNYVEDTGELNGTIVDEKSFIDTVKREWLTETSTFTLDVAFDKSGEHIVASRFTIQPVNISGTNMEKDMVRKLRQICADSPLNASVFHPYFVFFDQFELVRPTSIQCMIFGALTMMVISFIFIPNVLCSLWVAFCIVSIECGVAGYMALWDVSLDSISMINLIMCIGFSVDFTAHICYAYMSSKKRRPEERVKECLYSLGLPIVQGAFSTILGLSALLLAGTYIFLVFFKMVFLVIFFGALHGLFLLPVLLSLFGPGSCTNFDKEDEKEKISKLPQPYVIPHPTLLYNHGKDTSPAVSLNALEDRDLGLGTSEDSNSTESGSSQSRRKQRPVEQMDQPQTRYEDWRRSVGMLSSLSQFQTTPAPPPDYPGAHIADLHQRGLRNFGFLHQPPRPHQPQIARTSHPGDYRRSRSQHNLRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3D5</accession>
    <name>A0A232F3D5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase ATM</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_000011</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001115">
        <property type="protein sequence ID" value="OXU25092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F3D5"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000023">
        <property type="entry name" value="Serine/threonine-protein kinase ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="1758"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="2459"/>
            <end position="2774"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="2788"/>
            <end position="2820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2745"/>
            <end position="2766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1439"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2748"/>
            <end position="2757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU25092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2820" mass="324835" checksum="23BCEE3395BB3EF3" modified="2017-10-25" version="1">MSCMDRLSQIASLAKSKKVTDYKKAIKQLLEFWDDNSEITLQPITEYSRDPTPNERYDFYSWNDIFIIVHELFINEIDRISKLSGNAGKLDKERVTTLVFRTSEKANYYLKPKDVVNSTLQLLRYGSLHIFSEYYEIYLHILRKYVLQERSQRILLASKHWQELLNMCVSILQKIIPNVDYAKLLETIELIVKYGCDLSTLLFETRNLLPVIANILENYEPYKIKSADILFKLTFTVCQQIATDSRLTLCKFSESIPLSMIDIKGPEEKYQLYLLFVQVHHPKGAILGKDGSYAYDNEKWKAILNLLYKMILNDLRSVLLSENFTLLACEVFRQKLLTNLPCFSHTNTFHDSIYIQPRKKRRISDDQDKMIDLINDRDPKKAWPMIQITAALYKKYPDCLKFEEFVEFLETIIKLMKEACKTFAIMENLCELATVLVQNENTYNNKDSLQIYWDKIWDAALRYISMTHEDVIQKGCLLVQNLISHKKISNPNALLKLYLTKSIQWSSLSILTLKILCEYIVLPNEIKDCDMNSTLLTNNSLKLQLMQWVLNTPTRRLTDPLSIEEFSKTLIGLTLKSWYKAHDYGFQDHFKKYYIDLDHNLYDDQKTITINDIERCYLSVNFETKLLVNNDSNKDTPLLNENNLDNPYIVEDLDFLIHNLMQMVQAEDSDKELSSFITKTSIIANIISNLQAMNMIQCNFDEFCLVNELKTCLSKIFDQIININWSKNIRITLEITKALISLYQTKYDVKVKDIILTSTQFQNLKKIYDISKIEIDEFEPNTKSSLCIINSITVLALYSCLDADGEISELQMKIASTLLKLKKYSLSIKVDVICVVTMLEIYSNIPNSVVTEEFGELLMTFVMDVFQSWHKDDKVNRCLLYFVPNILKKLVYIDENNVHIHNVLTICKLYQEKFTKGVFGQMTHLSLVQCLNNIVKHTVFHNTGIEVLTYDVFTNFVNSCNYLVRLECLNVIDSIFSNTNLSNTWKSEFFEKLNKTVYDVFLMQRQLSEDEIQEERLLRSTSAMQVLATVICSKSTFQGPALFTLARIIVDKDIEPSIVKKTLQIINASNPSTKCIVEENLNYILTAWCRVASFGKFPHGLLNCSTEMDFYDRYARAIFPVLLREGKMQEAKSFCERLGVTFEQIFKTCSANILPWALSDEAAKTLEQMQNNQGNFEGIGKLGSIIKENLQHIIVQLVQRLHDLRHFYKVFDSTIDLPESDPPHFKAEVIDACFDRLIRIINSDPRQSVFACIILRKPSIFQKILLQLTRNVYTSKISQYKAKAFHQYIYFCSKIAVELNESYCDAVATYFVRDIGCTLLNLTKEKDSFITKLACKYMHKFFKGILPRRGAQVSNILSLCVKTLIPMIQDAKETSPLAKDILVLLLKERRECLAEAIERLGTLSSFLRSSEDDDNPESQVLRENLKHFLSASENKSCSVDDLIALKRQLSSKREELEELYSELETCQGFAEHCARSVLHRLVYQLIRLTESPDTRISLEAAKCLGLLGPADLCTMILHPQETQQRELIDKANMLTHKVCWMLSEFVLSDDIELRSVSSEVFYVVLDSTWGARVGIDECADSVENVAFLREFLKPFRSSQKGHDANKVTKPQIDAVELERVFDPQNPLWSEASNDSYNKWLSTITSEVARCLDNFYSKSLIPVFQLSVQFCELTLQRLVSLLIDVNSSLAKRICHCVNRFFEHHFKDDRIDDQTLSPSTPPQMLQGCKARDAIRCMLIVVNHLRIQTREQVTLDFDYLSIAMAAQFCSAYFSSVLYTELWCRSTLKLARDFDSIPIIDQIYEQENRQGRIAQDILKEAYMKIGDSDSIHGCGSSHLHNHGSRIPYYTNFQKLDKLILSHDVELSINSSSARGMVTALRESSLHHLAKRLLLSSTSMQVDPMDDLCYDSLWRLSDWSQIMSFKASQSSSKENDFSKSHYEALKCLHENDNSSLQKNLEQAYFCVIKDLCNISLESCRAVYPKLSQLQMLREIEELSSSHSDDYEILLANWKKQQYIYNSNFQYIEPILSQRAVMFKIREPIKSSPIIKDALIDVHLETARLAQQQGHINVAARSLETLSKVDLNNESGNRLLYHEALLAWTRKDEDMARFNLRTLIKKDSIKPNLLARALRIYGNWIAENKSENPQAIINKYYKKAIDTYESIPTKLIQDELRDNCKARAALAQFAHEQYLVITEYMKSPQFESLMECLDYSRNAVLQKAPNKNDRDVERAVQINTRQSSNDSIEIENIQKDKAMYLAIAVENYLSTLQDSDEHDFLVFRLVSLWLDNTHDAQVNKRLENKLALIPSYKFIPLIPQLAPHMNDNDQVFSLKISQLLERCARDHPHHTLPVLLALKNLYNDSKYCGKKTVNEEPRVLGAQHLIQKLLSTDIRPIIQEMERLSDALVMLAYYESEKKAVSKCIIPRNQALNNIKDFQHSIIPSITISIKKNGKYNNIVSVRKYESSFGNVGGINAPKKIICTGTDGIARPQLVKGKDDLRQDAVMQQVFTVMNSLLRTKKDAKQRKLYVRTYKVMPLTQRSGVLEWCENTLPLSIILTGDGSPKAGLHQKYYPSDYTPNECRKRLCNAKTAQQKYSTFMDCCKNLHPAFHHFFTENYLSPETWFERRLAYTRSVATTSIIGYILGLGDRHVSNILLDKSTAEVIHIDFGIAFEQGKVLPTPETVPFRLTRDMEVAMGVSGVEGTMRRCCEETMTVLREQREIIVTLLRVLLYDPLYSWAITPAKAATYQSEHSSRSSENKDSNSSGTTETNKLAERALLRVQQKLQGIEEGVTSSIAGQVERLIQQARDPTNLCKLFQGWQAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3J3</accession>
    <name>A0A232F3J3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_016515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001123">
        <property type="protein sequence ID" value="OXU25050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3J3"/>
    <dbReference type="STRING" id="543379.A0A232F3J3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011831305" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="311" mass="36210" checksum="EB7B635257909ED2" modified="2017-10-25" version="1">MDVKILLLLAIVGNTEICKGCRILALYPLPKQSHFMMINQLLKGLALKGHQVDLITVNTLPKSHSNYMQIMKLPDNANPIFSRYENIKNLHYNFSMMSWMGYLRCQKMEHPEFLNLARNPPKAPPYDVIIVQDAKPITSEAFWSRGTDYTRFTDSYTKKNVPDNVLIMSWIPQEKVLQHPNVKVFIMHAGLLGTQESIYYRVPMLCVPLAFDQWSNANNYVSKKIAVKVDLASVTQTKIDEALNEMLTNPIYRENIRKYSQLFRDRPQTAIDTANYWIEYVKRNGKNSLRSATMDFTWWQIYLLDVPDRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F403</accession>
    <name>A0A232F403_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001103">
        <property type="protein sequence ID" value="OXU25127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F403"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013122067" evidence="2">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="187" mass="20937" checksum="F32DA06C633AA9B4" modified="2017-10-25" version="1">MYSKASFVFLVSLAIVQGIGIGKSTDHALEISPSTGQGVRQIILKGSELALSVIKSIMRLMLKLLVKIARTHVVQLAFTSGLYALVHALFVNIFDCRSRDNIATIRTCMAQAENFTDTHFSQEKREMMSKAVQEVLADYERYLESEPSETIQPVDIDERKDDLQIAVESHEVGEVPNEEDNETISYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4V6</accession>
    <name>A0A232F4V6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001043">
        <property type="protein sequence ID" value="OXU25377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4V6"/>
    <dbReference type="STRING" id="543379.A0A232F4V6"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="252" mass="28379" checksum="AC788978BD033396" modified="2017-10-25" version="1">MLPSAINISFSNVVKATDGLAGHTATLFLFHGSGGNGEDFKQWLDILNKQELSFRHIKIVYPTAPIQPYTPNGRMPSNVWFDRKEISISVPECKHSIDIICNKASELIHREVARGIPMNRIVIGGFSMGGCLAMQLAYRFKRSLAGCVAMSSFLNDESNVYKSLKSDNPDDLPELLQFHGVADNIVPLEWGKRTFRTLKDCGVKGTFVKLDATDHELVQCELNYFKDWLLKVLPENYTKPPDESRFSIVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4X2</accession>
    <name>A0A232F4X2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000935">
        <property type="protein sequence ID" value="OXU25844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4X2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012714627" evidence="1">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="115" mass="13194" checksum="C1CF24AD3F3BE916" modified="2017-10-25" version="1">MKFFQLFLAFALVLAIIGSNGPDLLLLANSSVIEQLLQATTDSTDFAFPYGQAALFYTSVIPSPQRRSRHQISKVAQKDDEKVYYSDAYFHYQQILRKPNSLIEYYQLLKKAVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F605</accession>
    <name>A0A232F605_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAM114A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM114 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000946">
        <property type="protein sequence ID" value="OXU25787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F605"/>
    <dbReference type="OrthoDB" id="5597648at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007998">
        <property type="entry name" value="DUF719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842:SF6">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05334">
        <property type="entry name" value="DUF719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="78598" checksum="20EB8A764780BA51" modified="2017-10-25" version="1">MATSESDDFESADEELNARTEQAARSKRYTSIGSDSDDDVDYIPVQYHTPMKGASKKEYKSPLQARDNYIDKADDKSAGQLQMETNNVLGKSDPSEKNSDGAKNKVQESKNLGSKAKLACETDATKMSKVSKSAKSEVAVSNMEKPKTVANRRERPHRQQQRKPKEVQSLGAKKLGAIKIDKLPEVETTPDEVRRKAVAEGKPPPLIQECWEEFDETNLQEELRNAELKSQKKNKALVSETTENAEDLPEELKSNLTFKDIFKPDGWEGLGEDVELPDDLTDDKYHPVLDKLTTNSIDNDSANSGWGGWGNWGVSSFINTATAGVSTLTNHVTQGLSLLEETIGVPDPQDLVKTEIPSDERKKKPSEKTEEKQHEGIKEIPKESPSQYLPSAFGFGNFMSSMSSITKLVESTSNTVISGGLDTLEKIGKKTMEVLQEGDPGLKKKRAFFLNEADKPILSQILREAKEKADVEEKSAEEKQQARKVHFESLFDDYQGLVHLEALEMLSKQCNMKIQQQLVNLDGSELTSMQETLDEVKELCDLGDEDDEDEGEEEKDLKEKLQEACKDLGVSLTYDKLIDIWNDINSQMQSLESKEISSRELFQKAISSLAQFTAYSVERFHKTAEFLLIKERRSTVNEADSLVQLTKTLSAQIGFIANLYCDQLNKVQDETQKSENKSSITTIFLEVTPPMLVHTSKKHLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F644</accession>
    <name>A0A232F644_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS35 endosomal protein sorting factor-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS35L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000889">
        <property type="protein sequence ID" value="OXU26052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F644"/>
    <dbReference type="STRING" id="543379.A0A232F644"/>
    <dbReference type="OrthoDB" id="1734063at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029705">
        <property type="entry name" value="VPS35L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673">
        <property type="entry name" value="ESOPHAGEAL CANCER ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13673:SF0">
        <property type="entry name" value="VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="987" mass="112725" checksum="1718653284643E55" modified="2017-10-25" version="1">MTDYEWFARPVDYETRRRVNLEEANDHPLKPVTVTVMDGRSAIRRGTLRSTTSTSSSTRTPTPTQTTVPVNIGSIVDPLSSHSSLDGSDPLTQFVREEMDPLSKMASDEWDYSANANAVGRKAKDKLDEMVEPWAARKAVVLNKYTTLEKLSIVTSFLPGGEKVIMKVQPSGSLVDKVKTRLEQLDDFEDGSVRQMHGLSQQEYMARIEQLNNELVHAWHSDHRVKALKIAIQCAKLLVDTSVISFYPSKYVLVTDILDIFGKLVYERLKVKAEYIKPGSKMPTSLPDNFTPDMVPENAKETCQNWFYKIASIRELVPRLYVEMAIIKSYSFLTTSEFSTILMRLTRMIRGIGDPLVAVYARCYLCRVGFALKTSDLDFVKENFYDFLYAYKQLFSTSVKGDLLKQNLCLHSYLNLYTPALDWILQVMAATASENLLNEVLLRCKQQPNSALLLNTILTSFKPIYIVSRAMEFVNLIETCQDNGYPQYLLYRSLGECLIKESPPKEDCQHILNTVWKYMKGLNNYTRFMHASEINLFLGEIINQLGPSRAFEHFYPQLQNITEKIVANTQDFDSLLTMDNFLPLIDLFQKESIKVEVCKTVVEGLSKQSSPIVDPIMINALMFIMRIMHDSVSPICMYINTLLDITDVHYSALTVEDEKRQIGQLICGLILRVDHGRDFEKQLNFYVEARAAFHNLDSVHMQLVQCVNRLSVDTRKIVRGHHTRRTSAFVRACAAFCFITIPSLTLVHTRLQLYLLSGQVALLNQCYGQADSCFKAALSLVPEMPKYFDIDGRNKSTEPYLLTYLSNFLSTLLVVPDSPEHGVLYLMRGLLNVVQRYFVEDTAAKSHLYLRVLDLLSTVTQETYPYHVDKVDSNDKLYGSDKKFISEVNKICSKVMEELLNHLKNLGETDQLKKQSALALALFERMILRADLTDSSLSHVAVNLWNLSQKHDTVNSKLRLTTLEYMVRKSQLPQFQHFAEMLKKMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F657</accession>
    <name>A0A232F657_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein AATF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000825">
        <property type="protein sequence ID" value="OXU26311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F657"/>
    <dbReference type="STRING" id="543379.A0A232F657"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="190"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="443"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU26311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="62296" checksum="0DCEDDD44D63134B" modified="2017-10-25" version="1">MSSKKKPVSLAEKICNLVTAAPTTFGSDDEAEETKAKVVDYDDEIDENDDFENDFGSSNIRRRNVGLLEDTDKRYKAKKISKKDIFNQDDSSEAEGSMEEDDEDGTEDSADEGSDGASDVDGEQESEEENESDDDEKSDENEEHDDDDDEEEEDEELDFDDSIDLSNPLRRNRADDKGIKTMTTTNVRAEIEKGNCVREQLKLWENLLEMRIKLQKCLVSSNKMPQHDIYKDYASNDDFKKNCNDAKQKISGLLNNLLDLQSNLLNNFPETKGILKNDRKRKANDGEKVSNDEEDMDEEIPSDTEDEMNGEEEEEEEEEEESGDSEEEKVEKKGPPTKKIKLSEFEDILAKNHKAYTEYRNSVIQKWNDKTRIASGVISKGVNQPAVKQIEFALANKEKLLTKTQLKRSEYDIIGKSAVSLEDNDGRRVQEHDTEIYDDDDFYHQLLRELIEYKSADITDPIQLSKQWIQLQNMRSKMKRKIDTRATKGRRIRYNVHQKLVNFMAPITVFDTWTDHAKDELYSSLFGRIKAVGEESKEAKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F776</accession>
    <name>A0A232F776_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01000798">
        <property type="protein sequence ID" value="OXU26452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F776"/>
    <dbReference type="STRING" id="543379.A0A232F776"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="8">
        <location>
            <begin position="124"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="583" mass="67168" checksum="0C1F2AC1917CE66F" modified="2017-10-25" version="1">MAASTDVYDDLYLYATPDKFYIEPVRTKILLVIDRTSHQIYTQVSNPSQIPQTASRRKIWGIIGIVRLLACPYLIVIDDAQKVGTLANQDIFKIVSTFIIPYTRSMTHLDEKQIRNNNTYLEMIKSVLSTPHFYFSYAYDLSCTMQRLHNTPPDFLQMPLHERADSRFIWNSYLLQPLAARPEHHKFCLPIIHGFVSLNTIVVNGTPFNWGIISRRSIHRAGTRLFSRGIDSNGNVSNFVETEQILEVNGSKSSFVQTRGSIPLFWQQAPNLKYKPKPQIMPNENHLVACARHFESQIFHYGKQIIVNLIDQKGAEATLERSYREIVQELKNQNIRYEAFDFHAECRKMQWHRLDILMARLAPDQEQMGYFLLTRDGVLVSVQDGIFRTNCIDCLDRTNVVQSMLAKRVLSDALSKLEILRNVDEHPSVEFLFKQVWADNADVISTQYSGTSALKTDFTRTGKRTKMGAMRDGMNSLTRYYKNNFADGFRQDSINLFLGRYMVQEGECLTVSCPLESERNWRYATFPLILLVASAMLAAQMILPTRYTTEILLYMLFWAAMVAGTFTTIVHHGKQYVDKPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7G7</accession>
    <name>A0A232F7G7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000719">
        <property type="protein sequence ID" value="OXU26806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7G7"/>
    <dbReference type="OrthoDB" id="8190439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="122" mass="14367" checksum="4CE4CBC88A20376F" modified="2017-10-25" version="1">MDLVYIPEILTFGSFRSPQYRDYEQPWNKNYFDNGKTSSYYHHRQTQQQQHRESKDSCHLCKEKKRRSLAAYIRGKTRNNSCSEICEEEEEVEEQQKQQKQEASSSGPAEPDSKNKKSPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7U3</accession>
    <name>A0A232F7U3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_005573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000698">
        <property type="protein sequence ID" value="OXU26926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7U3"/>
    <dbReference type="SMR" id="A0A232F7U3"/>
    <dbReference type="STRING" id="543379.A0A232F7U3"/>
    <dbReference type="OrthoDB" id="17010at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF8">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU26926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19375" checksum="3CEB6E8006295B80" modified="2017-10-25" version="1">MTVEKKMATYSMQRLDAALLWLCLIGVGVSYYAYVVETAKEKDKDYQPYCDISEHVSCTKAFMSEYGKGFGLIPKDSQFYLPNSLFGIVFYTTVASLSLFNNYWNTALMLIVSIISNLFSIYLSRILYLLEDVCIVCVSTYVLNALIMILSLRKIREINRVSSKKRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8J4</accession>
    <name>A0A232F8J4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000685">
        <property type="protein sequence ID" value="OXU26985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8J4"/>
    <dbReference type="OrthoDB" id="7683074at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="14711" checksum="12E09CEDCBB3FF51" modified="2017-10-25" version="1">MWRRTRRAITSCFTFFRRCGRLDWNVDEDFAEILGHLADNDANDRQGHQFVGPYLPYDNNAAQLRREQPLQHRPDVPRGRRRSSPELVQKVRVALEEMCAGCLTEQLTDHPSGGDGCFDDDDGDDDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8N0</accession>
    <name>A0A232F8N0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_008449</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000688">
        <property type="protein sequence ID" value="OXU26962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8N0"/>
    <dbReference type="STRING" id="543379.A0A232F8N0"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000310">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000359">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU26962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="621" mass="68691" checksum="FDD8F53C0267D264" modified="2017-10-25" version="1">MPRHLGAAYGAARLGYHQQPSSPSNYYHLLPASPPASPPSSGYLYQPLQQPLISTWPRTMPQDEEMLMASSQHHVGSPMVVNGPPSPAHSDSDASSSSLELGSVRGGKHAQLMCRWHSCGRWFPSLEKLAAHVSKHHAAPGPKGLFYCGWEGCQRGERGFNARYKMLVHVRIHTKEKPHTCFECNKSFSRAENLKIHNRSHTGERPYVCPVVGCNKAYSNSSDRFKHTRTHSVDKPYCCKVPGCPKRYTDPSSLRKHVKTFRHYANNNNDKLQENSVNSSAIVKEEIAPSAMETDAFELKSKGCNSSKSDSDKKDSSIESNTTSTSVCSISSDSPKATSSTSFEEQQKFVEWNNMYNNLQDRKEHHDAHATTSSSSSLSLSYEHDLHAGRYSRSSLHDDYILPDRHYNLPAHVKQPPTPYPIEMKHCLPASPPDPLMATTPRIGMQSTPIKSEDKASGVDYRNIESIVNGSTITPLKQEPYVAGSDIVRNSVIKRAVAQSPPTVEQEQSSANNSSSECCCKHKCCRHSEKDSVILEKTKILSDLILHSENPLFKHLLDSVDLQYGLKKMWSGSQQAADPEATTTAAAAAINTCAQDLRAKAAEALPTDMEQDLPLDLTINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8P9</accession>
    <name>A0A232F8P9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000718">
        <property type="protein sequence ID" value="OXU26823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8P9"/>
    <dbReference type="STRING" id="543379.A0A232F8P9"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="318" mass="36315" checksum="444DBF13D9B56EC4" modified="2017-10-25" version="1">MSDSKFQPVTHCIFDMDGLLINYTSQMNYESWANFSDTEQLYTTVFNRILSPYGKQFTWENKAVTMGFHTNQLVRYIIDTFELPMQQEELTKRLQTDYAAIFPSTQLLPDSETVYKKIYGTICEKYGFSYGGDLAFQVLGRPERVGAELIINHYKLPLSIDEFQDFYHRLQKENFTDVQMMPGAERLLRHLKKHNVPIALATSSSAESFALKTKHLTEIFDLFHHRVLGGSDPEVKQGKPNPDIFIVAAKRFPDSPDPAKCLVFEDAPNGVQAGINAGMQTVMVPDPHLPKQFTEKATLVIDSLEHFKPEDFGLPKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8Q0</accession>
    <name>A0A232F8Q0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000678">
        <property type="protein sequence ID" value="OXU27035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8Q0"/>
    <dbReference type="OrthoDB" id="10605361at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646942" evidence="2">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="143" mass="16468" checksum="4B93819B01AF3EB3" modified="2017-10-25" version="1">MKQLLSLLMCFFLVSPSRSAEDATPTLTPTTETPATSTTLNEEEHKAKELPIDLLSPDKVLLDPNVVLARVVRDTYSNYGGGWGQRQSFSKPYERRPFGIDGYYNRLINSYRRLEPPRRKAEEVRRRYEAAPKRFKVYPVFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8T4</accession>
    <name>A0A232F8T4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000706">
        <property type="protein sequence ID" value="OXU26878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8T4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="23" mass="2638" checksum="E6E5DE98E10AD4EE" modified="2017-10-25" version="1">MVRCRKSVNTIMSSIEVSYTSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8T5</accession>
    <name>A0A232F8T5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000710">
        <property type="protein sequence ID" value="OXU26853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8T5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32908" checksum="8FFB8F805FA70806" modified="2017-10-25" version="1">MELLVLADKYVMQELNKACEKYLCDNLDKTNCQAIAENKYSQHGILGCNRFHAPKGTVCYNVNMEDDDQNQDYDIKDECLINDLKGIVMELLVLSDKYGMQELKKTCEQYLCDNLNQNNLTVKQSREFNTYNMESLIVIHSKYQRVSEIHWTINNWNSIAKSNGEIKSKKFDLFNSKIVGQLILNIKDGKIAVPIRIKRESLLSLQSSISLSITGSVSSLRLRNNGVVHERFTKGLSTYYFKLPDDVQDEYTKTNESLLLDSLKRKSRELRSYYLAHLLYPSSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAG3</accession>
    <name>A0A232FAG3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tectonic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tectonic family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000599">
        <property type="protein sequence ID" value="OXU27470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAG3"/>
    <dbReference type="STRING" id="543379.A0A232FAG3"/>
    <dbReference type="OrthoDB" id="184109at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057724">
        <property type="entry name" value="TCTN1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF2">
        <property type="entry name" value="TECTONIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25752">
        <property type="entry name" value="DUF1619_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3 N-terminal" evidence="11">
        <location>
            <begin position="279"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="10">
        <location>
            <begin position="580"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU27470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="96965" checksum="6A21E295C7655994" modified="2017-10-25" version="1">MMAELHLVGTIASARNFQQPRLFCKWSFSTGSGWKIINGNGEGQTQECCDPFSNQPVWDHPVDLHFATQTLQGSPKILLQVFCRDNFNRILFVSYGVCSIPLKPGFHSIDCHTWKPIGNWQDRLKDKFLGTTLQLKSPDILVNADDRFELLTESMGTVQIDLYVLKVSTMSTIKSVTLIFLQLILLFLFTFGQEVQDSNDSCQNNTLCENSTVSGNKDEDYDINDVNIRELAGGIFKSSDSTKTTTTSTESSVNKEVDLELNLDLSKIQKVLGERSKNKFCSCDLTTSVCDINCCCDLDCTEYHFKVFSHCIDREIDKEKDNWYCHEKPFFRHNDTRFILEKIVDSLFCVASDNLPPVYSATSHLQIEDEKSFKKVINNNKPSKFKWILEQKKLIVPEFNISNSYRHGDILWKINKNSLQPLELPQTGFGKACDFKKTVKFLEDWKDSCHQNNLNNKNVFLFPTNFSNFTIVALPLKFNSQFLLQNCPNSICRAINVSYCSDSWTLCKKNITVQSYCTEKSVCYNIVKKMRYMIYHNGSEGIQNIEVQIQLANISDSFKQEFEILHKWIGLNQSLVFERSGNPGYIAGKPILIGTQTVNKTGDVEVKYVIFNKTHQHLTLPMADRTGICSEVESYPVKFLEDLKLKCSIVVKSNNFSTSACIKLQNRTFESIVNFMMFKNFEKVNFERQFVSKSGNISDNGTESWAKIFFEKIPQNVITAQITENEIQCSGLVTSVVFDIVHSLISKPGTNKNHVILGVGITFSQEVDLKWPKCTGKNCQDVLQLDLVSYVAFHDVSRPTRYHIAGGPNLDISLPYDFFYPFLSHSKSIAPILNCITIHHTFIMTFIILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAV3</accession>
    <name>A0A232FAV3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000501">
        <property type="protein sequence ID" value="OXU27974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FAV3"/>
    <dbReference type="OrthoDB" id="10029564at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="170" mass="18811" checksum="A755A41FA0FF51EB" modified="2017-10-25" version="1">MQEAQLLEEAGSGTTGSTGXXXXXXXEGGERREEDAAVVVPDHQGNLRIIVKKSKPTLGIAIEGGANTKHPLPRIINIHVDGHKVEGTWFFILMKSVEHVRRESRCAITVVWLITNEITPLCAGLHHQEVARLIAESFARRDRNEIEFLVVEAKKSNLEPKPTALIFLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBK2</accession>
    <name>A0A232FBK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Death-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000533">
        <property type="protein sequence ID" value="OXU27833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBK2"/>
    <dbReference type="OrthoDB" id="5973225at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024130">
        <property type="entry name" value="DAP1/DAPL1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15228">
        <property type="entry name" value="DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="52" mass="5816" checksum="37E760634A2E8794" modified="2017-10-25" version="1" fragment="single">PPKAMIVSGVQTKGHADFPPEAVQHYHDKPIPSHDNRSAHNSRPIVIQQPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBQ4</accession>
    <name>A0A232FBQ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000521">
        <property type="protein sequence ID" value="OXU27879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FBQ4"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="1216"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1305"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="264"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="402"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="907"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1310"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1368" mass="155987" checksum="797E78A3547D84B7" modified="2017-10-25" version="1">MNRIIQMGEKSREVERNAKRLQQDELTLVGDFRKAISKLASPEQYDLIRSALMALENESEQLQGSVEKTDSMGYDAEGKSRNEKGRDESEAKLRRRVEELEAENQSLSQSIEELDKQNAESIERVLSLKEELQKKHHSLQGAYEQLYVEYNQALGKIENLQQQQQQKPELSKAPNKSSLDTAVQTLAQLKLDKETEIRPAKEDKQTEISPSKEDKEVEVDLMPEDQQDLASELKKVNDILKNAPLEPSNEHLNDSVFVAVARQFVELKWKKETLERKLTEQSRELKETQELRDSLQIDCEDMQTNIESLLMEVQHLKSNLPSIPEASEERVASLETETESLQAEIIALRKSKADMSSELKAIKAAIREDGGGGGGVEFATRIESLLAEQNKSKSSKDPAELLQATLDENTALRRRIDVLESELRVSLERCKGLDENIELIEELKLDLENARRELKIALSNNKRLENSLTILQEAKNEVDADNEVLSREKEQLEADLKLLSSGSDLKKSDGDALAELREELKKSKEEKDDLEYDIRNMRNELDQSLEQLEANRAEIEKLQLDNERLAKENGKLLDQFSETQKENLDKVELLNTEMTLLQQELDGNKEELEKTMRYLSDMEEKILTLKNENERLKLKEQLEERSLDHTKEELDAALKKLSDLEEKASMLESENTRLQDELIRTGDVDSENKKLVEAIEEKQKELAKNEEEAANVTTKLKCTENYISSLEDENQILESKLAQVKQENESTKKEIEELRQQLESERRQKEADGNELSVTYQTELDKLKGENERLKSELDKLLVEKRDVEVNTRASSNAQVPVSEEERSQLLNQLSEKSKEIENLKATISKDKDSAQMARETVENLSQLISSKDNELIKLNATVDMFRNERDEVVKLVQEKHNESLQYHAEIQRLTQLISDQTANLQKAIAEKDATLASLQEKESQLLWTQNELQVVKQRLQNIEESNNHGERCGIAEHTLLSKHVSTLEEKNKAMEAAILQDQSNIRYLQEQLTEAQSKETIALKEVDRLRNHLVEMEANYTEEALQSEEIQRTLEARLMQAEEKLKNSSTMYTSASVRANQQVETLQQQLALIVQQRDDLQNKISSAEDKVLSYSASLTNLQLVLEQFQRDKEKDIQAATEKLRAELQQSYKKQDELVSEITSLKEQLAEAKECLRAASRLTEQLEKKSERIELLNQEVNRLTELVNTADQRIEEAKKSGEGKVDRSLVKNLLLGYISSPQNDKTSVLRVFANVLDFNETEREKSGLTDSAAKNSWFSSLVNSSPASSKEQEASLSSAFIKFLESESQPKPQLPALPISSSPISRPGHSRQHSSSSTHSTLLLSNVTLPTFPDFVPARNTGSILKEVLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBR9</accession>
    <name>A0A232FBR9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pacifastin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000516">
        <property type="protein sequence ID" value="OXU27903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBR9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375834" description="Pacifastin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7124" checksum="FB91FF912727FD8B" modified="2017-10-25" version="1">MKSLALLASVIVLMFGFVVGASTENHEKREAGKCNRPGQREWDWCGNPCFCSDDLVFLCEDVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDE7</accession>
    <name>A0A232FDE7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000391">
        <property type="protein sequence ID" value="OXU28705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDE7"/>
    <dbReference type="OrthoDB" id="7612378at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12122" checksum="28A4556E97218691" modified="2017-10-25" version="1">MLQHQEQWLEWYQGPTMEGGVQVSSIFKQSSAPYLYTFSSVLKQYTVLYVTLVEKACCSIYKMDIILDTHGFKGQNGEYTIKELAYIDPNEPAAVPQLVTFQPPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE60</accession>
    <name>A0A232FE60_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_002081</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000344">
        <property type="protein sequence ID" value="OXU29041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE60"/>
    <dbReference type="STRING" id="543379.A0A232FE60"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000147">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="134"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU29041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55030" checksum="26FE137135F59ED1" modified="2017-10-25" version="1">MIRQESYFKLKNYPNFRTEHALIYDSVKIFAEGFKRLKSATKGNLKKIVCNKTESWEHGISLNNFIKSVEIKGLTGPICFDNAGFRSNFEIGIFSLEYSGIKETGKWNSSKNVEWFINTSSGSNQDSLSLHNTTFRVLIALTKPYGMLKETVSKMSGNEQYEGFAIDIIHEISKMLGFNYTFSVQMDNVYGSLNQDTKQWNGMLRKIIDDEADLAITDLTITEEREKAVDFTMPFMNLGISILYQKPKAAPPSLMSFLLPFSTNVWLYLIGVYIVVSTLFFVIGRMCPAEWNNVYPCIEDPDELENQFTFRNSLWFCIGAVMQQGSEIAPIGNSTRMLAGCWWFFCLIIANSYTANLAAFLTVETIDRPIKNVDGLANQNIIKYGAKKGGSTLDFFKYMIANEKEVLTADNDEGKKKVLTENYAFLMESSSIEYIQERECNLSQIGGLLDQKGYGIAMKKSKFFVVSNNVYEKHLNICLPLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEB5</accession>
    <name>A0A232FEB5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_013877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000335">
        <property type="protein sequence ID" value="OXU29124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEB5"/>
    <dbReference type="STRING" id="543379.A0A232FEB5"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20504">
        <property type="entry name" value="CYCLIN_CCNA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20505">
        <property type="entry name" value="CYCLIN_CCNA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032447">
        <property type="entry name" value="Cyclin-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16500">
        <property type="entry name" value="Cyclin_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="236"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="9">
        <location>
            <begin position="329"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="333"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="459" mass="53274" checksum="4931E52C232360CB" modified="2017-10-25" version="1">MATIRVHEDQENRRLPGKENVGLAQQQNKRAVLGVLSNNFVRSAKPDACKENEKFGKAKQNNYVAPYIEPFTIYEDKKEEPTFQIYEDKLQTESSIVLRDAHETKKIEVKQSTEVKVTVEREKPILEVNPTIQSTVQPYRPVLQEIEEYKHENVLSPEEGPMSLDKSLLLTGSNQKDSRSRREICKTSRSNFYDIDEYRADIYHYFKSVEVMHRPKPGYMKKQPDITYSMRTILVDWLVEVSEEYRLQTETLYLAVSYIDRFLSYMSVVRAKLQLVGTAAMFIAAKYEEIYPPEVGEFVYITDDTYTKKQVLRMEHLILRVLSFDLTVPTPLAFLMEYCISNNLSEKTQYLAMYLCELSLLEADPYLQYLPSHLAASAIALARHTLREEVWPHELELSSGYSLQDLKECINHLQRTFKNAPNLPQQAIQEKYKSNKYGHVALLLPRSSEPFECEDSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEN5</accession>
    <name>A0A232FEN5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000321">
        <property type="protein sequence ID" value="OXU29231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEN5"/>
    <dbReference type="OrthoDB" id="7667520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="159" mass="18973" checksum="CEAFD3162C0A2BB9" modified="2017-10-25" version="1">MVAALAKEISEANGDTPKKFYFYSVTVEVLLQLDLDYFNNRQTCHFFKRFKLDIECLGQECSQWSKNKLYIKNKEKIKKKKVINDCAERAVHLCQVYVNILTKDEQQKQYLIQCVDEYNKKISDVTKKKLGQKTKKNPRVSLNCNYKYRYIFYVQKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGT0</accession>
    <name>A0A232FGT0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000279">
        <property type="protein sequence ID" value="OXU29537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGT0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="155" mass="17465" checksum="9F544599D229E95C" modified="2017-10-25" version="1">MRATRHHRLCLRHLWNALNESPRHLSAQCPSNRFRRTSSNSSNSSNDPTPGVCALATPPSSSSRRTLRTRIILLSMCIYLQGTSNINSPTVSRKRALGFGECRRRLARHPTPSSSPQLCVCVCVVYNYRCPACSSRAQRQRRDYLLIVRPGAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGV2</accession>
    <name>A0A232FGV2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_008942</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000211">
        <property type="protein sequence ID" value="OXU29996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FGV2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="861"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU29996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="105547" checksum="467D22B7372C928F" modified="2017-10-25" version="1">MDPLFWASILVISSLAYYYFKKKLDYFEELSIPYVPGWPLVGNFLGVLTRRQHLTELLKELYDSHPEAKYVGAFDFGTRPVIVLRDIELIKSVTLKHSDKFPDHMPLADRTTDPTLGANLFNITGDEWKELRNVLTPSFTSSKMKMMFHLMADCADNFLKHVKCLPPEAKKYMDTKDLKRSQRNNMDPLFWASILVISSLAYYYFKKKLDYFEELSIPYVPGWPLVGNFLGVLTRRQHLTELLKELYDSYPEAKYIGAFDFGTKPVIVLRDIELIKLVTIKHSDKFPDHMPLADRRTDPTLGDNLFNITGDEWKELRNVLTPSFTSSKLKMMFQPMADCADNFLKHVEGLPPEARKYVDTKDLFTRITTDIIASCGFGISVDSMRDRNNELYVLGKKSTHIEGIQGLKFLILKSFPWIVKLFKLKHVTEDVSKFFANLVSTTILTRDAMGISRPDMLQMMMDARKKKSEHLELDMSMMTSQCFGAFFXSKLKMMFQPMADCADNFLKHVEGLPPEARKYVDTKDLFTRITTDIIASCSMGINVDTLRDRNNELYVLGKKSTHIEGLQGLKFLIRRSLPWIVKLFKLKHVTEDVSKFFANLVSTTIRTRDAMGISRPDMLQMMMDARKKKSEHLELDMSMMTSQCFGAFFAGYESLSTFMCLMAHELAIHPDVQKKLQNEIDEVMKESNGKINYKAINKMQYLDAVFNEIARKHPQNPFIDRICVADFEFPPAFPDGEPITLEPGTSIWIPVAGIHMDPKYYENPEKXYLDAVFNEIARKHPQNPFIDRRCVADFEFPPAFPDGKPITLEPGASIWIPVAGIHMDPNYYENPEKFDPDRYYQKKVAKNDALNLSFGIGSRSCIADRFSKMLVKILFVLLLSRFNFVRNEKTCSPLKYSRKNIIITPKGGFSLDIEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH77</accession>
    <name>A0A232FH77_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000226">
        <property type="protein sequence ID" value="OXU29880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH77"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="5134" checksum="CF2F7C79CB85C78C" modified="2017-10-25" version="1" fragment="single">GGTQTAGQAERPRSVLVSSSSKSGECPQRSHPSDLGGKTLVSHMRPEGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHV0</accession>
    <name>A0A232FHV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_014921</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000172">
        <property type="protein sequence ID" value="OXU30324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHV0"/>
    <dbReference type="STRING" id="543379.A0A232FHV0"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000128">
        <property type="entry name" value="Isoleucyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000009">
        <property type="entry name" value="Isoleucyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="81"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="732"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU30324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="960" mass="109833" checksum="A888E0BE36370E63" modified="2017-10-25" version="1">MSMSLRTSLWRAKASLSSQARVLFRLYSSQREKPVEKRYTDTILLPKTNFQARITGKKRVEMDKYLQDKCGFSELYNWQRANLEGPDFVLHDGPPYANGDPHMGHTINKVLKDITIRSKVIKGQRVHYVPGWDCHGLPIELKALTSAKKRVSELTPMQIRAQARKFAEDAVNKQRQVFSSWGVMADWKDNGCYFTNTVAYIVNQLNQFYNLYEKNLVYRDFKPVHWSPSSRTALAEAELEYRDNHQSKCATVRLPIVELPSKLAAFQGKSIFGLTWTTTPWTLVANQALAYSLDADYCLAEDNEGNLYILAVELLEKNIEKIGQLNVVTTFSGNDLAGAKYSHPITGITLPFLPGDHVNTEQGTGLVHTAPAHGQEDFLVALENDIPVLSLVDEEGKYTAEAGSDFHGLKVLEQGTDAVIARINKNILHTETISHSYPYDWRTKKPIIVRASHQWFIDTNSIKDQAMKCIENVNIYPAQHRTSWTNALLTQLKQRPYWCISRQRVWGTPIPVLYYKDTGKIFITKEWIERLCEVLEKYGPDCWWELPVEKLLGKRLCAELNLSGSEFRKGDDILDIWFDSGISWSAVLPEKKANLYMEGMDQFTGWFQSSLLTSVALQDCAPYQDLFVHGFAVDEKNNKMSKSIGNVVDPEEIVKGGKDMNKKPAYGVDILRWWVASHGTQHTLVPMKNSLLQGSADTVHKLRLVFRFLLGALHTYDENKNITVEPQYHYLDKYMLHQLYHYHQEIQSLYEKYQYHNVSKTVVNFITNDVSAVYCHMIKDRIYCEKIDSPYRLGALDVIGEILSITTRSIAPILPHLAEEVWLHHPENLASVPIFHTQHRSLESWNNLEYKEIIEKALDLRSEINKLTSQNTWLSKATIKANSQDFKLLSSLQKDETSSLSELCDICQVSSITLLQDDSCDHVNVSLEDIKGQLCKRCRRHPEPAPEEICDRCTEVLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIE1</accession>
    <name>A0A232FIE1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000168">
        <property type="protein sequence ID" value="OXU30363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FIE1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="438" mass="49816" checksum="51180E67E3D3E6DA" modified="2017-10-25" version="1">MSPVRWSRRRSSSSEESERNCYNVQTSSVTTERISSSGCSGSSSQHKKDKKKIREERRKASCEKKNPLLDRVRNTRLSFLKDSNHGELCDLEPEDDLEFQRQQQFRSMCELRAADAGLARNDFRRSICENDLKQIIAKELEEDEEEEEELKKRKRRSKSQSRLPCMGQSDERFVLFGFKLNESPKPRRRRWRKSKDTLCSAKSDNEQEPPSNDEKTAGVEGKTPAGKSKFDTVTPSSCLAAKFRAMQNRYLKSSTSKLIGKIYKKDGDSKDKERKRLRSFSYGTLPGLDELRTNPLFEDHDQEPEDNDNDSGILDNDSATSSLLDDRCSSVASESLVHGSSAEXXXXXXXAEEQGAQAVPEHVAARRGRGQQRRLVLPGAEQQGVDARAEQARGHPEQRQREEDAHREAAPGDERAVPRHLHRQDARLRGLPRGPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIJ2</accession>
    <name>A0A232FIJ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIJ2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="12973" checksum="E23312328C943A07" modified="2017-10-25" version="1">MNHVTISEGFKVTFLDLLLSSAEKAAIYVRNKELVQAYDAKKALFPMYQGILDAKLSRKLERRKLVESAAVAFSDFLGFADPSDDFFERMFSYCSNGDLERLIKETSDEIDETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJD6</accession>
    <name>A0A232FJD6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_012658</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000114">
        <property type="protein sequence ID" value="OXU30854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJD6"/>
    <dbReference type="SMR" id="A0A232FJD6"/>
    <dbReference type="STRING" id="543379.A0A232FJD6"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000019">
        <property type="entry name" value="Bc1_11K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU30854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10369" checksum="8ECF84028C5DE60A" modified="2017-10-25" version="1">MSMLWSFFESLAPTVRAEEEEEAELVDPQKILREKCSATQKCSKLQEKLNTCNDRVNSRTQTAETCVEEVIDYMSCIDHCAAKTLFHHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJI0</accession>
    <name>A0A232FJI0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000129">
        <property type="protein sequence ID" value="OXU30700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJI0"/>
    <dbReference type="STRING" id="543379.A0A232FJI0"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF185">
        <property type="entry name" value="NEUROCALCIN HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="207" mass="23506" checksum="A74044616A3BF52E" modified="2017-10-25" version="1" fragment="single">AEIEDLGGVLGGSGTVGVGIRHRPEELATLAAKTRFTRKEIQMIYRGFKQECPTGYVDEDAFKHIFSQFFPQGDASQYAHYVFNTIKQKQTTGKINFEEFLTILSNISRGSVEEKLQWVFGLYDLDGDGLISKEEMLDVVGSIYEMLGRYTTPHIAEPHQAAREHVDRIFHLIDANKDGFVTIDELVQWCSKDEHLLRSFDTLDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJM7</accession>
    <name>A0A232FJM7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_007320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000153">
        <property type="protein sequence ID" value="OXU30517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJM7"/>
    <dbReference type="STRING" id="543379.A0A232FJM7"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF76">
        <property type="entry name" value="FI20010P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="6">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="654" mass="75532" checksum="B2762BED2F652C02" modified="2017-10-25" version="1">MSSLAKLEELKMDIRSLLVSRNSENITLPLLNKLYKDITDQDIPYIDFHYTSLKLFLASMPEILHLEYNKKNELCAYHVESDKSKHISILVSKEKKDTDKEKNNRRRKRNLIDPRMLNEILSELCDSSTAQHGVNKKVKKADVLSSIKSKIGEYAFYDVQDLNNQLNELTHILYYTDEFIYFKHGAPLVKKRTNNKMTDAHSRNDMDKKTEGFAQNSSVGDLIRSSTRERLQKLIEKHPNGIWCNQLPKLYQREFKLDLEYTDLGFSCIIDFVCALSDILRIVTAPNSKHYVLDARTPVDNYEYQSSNLIYENKVLEESDNVAALPANLSTSAIKSLKPDDVMYDETIDHINIPSVKYLDVIISEVHHPSFFWAHFMNNKKVVNSLMQYLQEFYRSHDLCRYKMPSILVKPKVHVACLFGNMWHRGVIKKMTPEGPMVHFYDYGTNEIYSSEDLYFLSKKFSAIPKQAIRCNLLNVKPVGDNKWSSDISYKFTQRVFNKPFVAHISSIDHEENSMVVDLVDTNHHSIDIYISRWMVKNKLAEWITPVTKTMSALNNCNQYMQKLSLGSSLDDTNSKEDTDIKHNISMESDTTSENSSTTSFLSIKSSKKLEILRKYKMKFLNNSAGLSSPCYSSDGDSSNEKESSFKGPTRFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJQ8</accession>
    <name>A0A232FJQ8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000102">
        <property type="protein sequence ID" value="OXU30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJQ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="71" mass="8364" checksum="02CD327FF57B8FAD" modified="2017-10-25" version="1">MHEYLDMTELVDKTFSTKKTFTSILKKFISKDLAVMFTAARKPRDATKMQNTAVFKDTNFFFMHVCHLPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJT5</accession>
    <name>A0A232FJT5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000123">
        <property type="protein sequence ID" value="OXU30759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJT5"/>
    <dbReference type="STRING" id="543379.A0A232FJT5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="22125" checksum="148E921A6D271BA9" modified="2017-10-25" version="1">MPAYHVLKKGTSSSFQNTERTTTFTISSIFDVVKLCSTNITEVKQGAENMIQSLTSGHRDKKLLQEAQQMLDDSRAKIEFLRMRIMKLNQAREQQHARGDGPAPNGDASGNKVRYEPNLELALEERVEELRHRLRIEAAVVEGAKNVIRLLQSAKVADKKALAEIRRCAIKVDKVYYEFEYLHVRGRYAYEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJX6</accession>
    <name>A0A232FJX6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein THEM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000095">
        <property type="protein sequence ID" value="OXU31034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJX6"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF11">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="322" mass="36755" checksum="441EAAFA2EA42FAA" modified="2017-10-25" version="1">MSTTFNHPAIKSPDLLLYSPFQATEQRTILHEESLTFSLYNPQALRISKFEEPEARQRIKEANEQKGNKETVRPVMITCWVLVGALGAMVLLHALFEVHYFLRMIITVFLARFCRKRVHILDETSVYAQLIAKQTPTGLCTTTDIDWLLYHMNNARYLRELDFARADFYERTNLYREICSQGSGVVQGASTIRYRRFLKPLSIFKITSKIIYWDEKTIFMEHRFVTPSDGFVRAIAICRQRLLDCSAEAVMGVLIDRGVKQNGSVEAGVTQVPHVRPEMPLEVARWLECNDISSANLRQQAPAAPQPQSPVPPPPQAVSTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKT8</accession>
    <name>A0A232FKT8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Solute carrier family 25 member 36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_005030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000087">
        <property type="protein sequence ID" value="OXU31120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKT8"/>
    <dbReference type="STRING" id="543379.A0A232FKT8"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000028">
        <property type="entry name" value="Solute carrier family 25 member 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="90"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU31120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23522" checksum="9DE04A02A7AB12E9" modified="2017-10-25" version="1" fragment="single">FVSCTATNPIWFVKTRLQLNHHTNQTGALECIRRVYQQSGIMGFYKGIVASYFGISETVVHFVIYEAIKAWLITNRARMPSPDNNSKTSRDFVEFMVAGALSKTVASCIAYPHEVVRTRLREEGNKYTGFWQTTNTIWKEEGHRGLYRGLATQLVRQIPNTAIMMATYEAVVYMLTNQFEHAANNNSSSIQNTQFYSDSKNKRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLN6</accession>
    <name>A0A232FLN6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000047">
        <property type="protein sequence ID" value="OXU31572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLN6"/>
    <dbReference type="STRING" id="543379.A0A232FLN6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="160" mass="19214" checksum="4D78A216350C7E05" modified="2017-10-25" version="1">MVLFKRSSFTGSLETKLLHKIQQFQYNSKKLVIKLKNCRSNSLITMKTVENLLKFIKRNQKIGEIKILYQEEKYEELTDILKDSFEMTKHSNPCLRYGEIPIDRAEQLRILLDSLWQLEQYETRKEKIFRSVHRDYRLSGETYYTAALLVYYEQGSREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLY8</accession>
    <name>A0A232FLY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="14">ITPase</shortName>
            <shortName evidence="14">Inosine triphosphatase</shortName>
            <ecNumber evidence="14">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="14">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_000713</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="14"/>
    <dbReference type="EMBL" id="NNAY01000039">
        <property type="protein sequence ID" value="OXU31672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLY8"/>
    <dbReference type="STRING" id="543379.A0A232FLY8"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU31672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="208" mass="23396" checksum="96EF17F70D3B37B3" modified="2017-10-25" version="1">MVLFTHQTSHKLQTMAAKPIVFVTGNAKKLEEFIAILGPRFPREITSRKIDLPEYQGEIDEICIKKCRTAAEIVRGPVIIEDTCLCFDALKGLPGPYIKWFLDKLGPDGLNAMLVGFDNKGAQAVCTFAYCEGKPDDPVLLFEGRTHGKIVSPRGCRDFGWDPCFQPEGKDVTYAELPKEVKNEISHRSKALEKLKEYLLKEDKKNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDS0</accession>
    <name>A0A232EDS0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005997">
        <property type="protein sequence ID" value="OXU16495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDS0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8223" checksum="9B452AA4D0A21786" modified="2017-10-25" version="1">MLTNGKLLAKVMVLRGSLANHNQLLGYFLPGITTTSRELYYLVYLVFMDLLLLLLNNLDHLGRDGLDDTGGQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEC0</accession>
    <name>A0A232EEC0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005398">
        <property type="protein sequence ID" value="OXU16693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEC0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="17794" checksum="124CD93941D89A54" modified="2017-10-25" version="1">MAVQFWGPGVEKVPELEMHESDPGSDDDGYASEVGSVGEAGEEVGLSTSPAAMDVKRMATDVQISYRVISAGDEPSPGEWIPCHREDWDAPEESCLICGQFLGDRASCLRLSGKEISYRVISAEDEPFPGGWIPCHREEWDAPEESCLHLSGKEQWIPVPCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EES0</accession>
    <name>A0A232EES0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01005238">
        <property type="protein sequence ID" value="OXU16847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EES0"/>
    <dbReference type="STRING" id="543379.A0A232EES0"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="332"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU16847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="558" mass="65083" checksum="0E6AAAEE1747A5EE" modified="2017-10-25" version="1">MSRNQYSIVEYHSKQERNSCGYCRSPNTSYSHGMTTQLLTVQHYQSLIDRGWRRSGCYCYKPMMKRTCCPHYTIKCDALDFKLSKSQKKILKRMVKFLKNELSKEEEKKASRIGCDEDIVRGMEIPDYSMFTERADTDASKMQVTSVSEELSHRLNSTVDNTNLNTSTSKPPDKNIASTPTQPMETSSNELRRANFDSTRAPQKKAKQLRIERKQQKLLAQGKTMEEINAIMKKNRPQNTGKTLEDFFDEIGKCSNKLELKLVRTSPPSDDYKKNAKESFQVYKKYQTSIHGDKLSKLSEERYARFLVRSPLRMKLVRVMSEEFLETLDKSAKLYKKYQMTIHKDKPKNCDKRAFFDFLVRSPLQQWIPEDGPPAGYGSFHEQYWLNGVLIAVAVIDILPSCVSSVYFFYDPAYSYLSLGTFSSLREVFLTRQLNKHSPDLKYYYMGYYIHSCMKMRYKAKMRPSKLLCPETYVWCDIDKCLPKLDASKYSRLNEDLEAVDENGEVDTNQVLILYHNKAMMYGVYRRHVQNEVVDNEIKEYAPLVGKQCALNMLYFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEX6</accession>
    <name>A0A232EEX6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005189">
        <property type="protein sequence ID" value="OXU16910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEX6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9709" checksum="3A428B631737FC78" modified="2017-10-25" version="1" fragment="single">KHLFQVFPITEENYTLAWDVSVKSYENKRLIISRHLSLLLHLPNQDKEGYHRGVERLADEAQQLVQSLASLDVTLSPEIIVQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFP0</accession>
    <name>A0A232EFP0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 tri-snRNP-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004979">
        <property type="protein sequence ID" value="OXU17144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFP0"/>
    <dbReference type="STRING" id="543379.A0A232EFP0"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU17144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="90885" checksum="C1672FBAF8329A00" modified="2017-10-25" version="1">MGSSKRHKSEKSRESKKKRHRSRSRSVSVERERTERHCKHHKKHKKKDRKDYDSDVEIVGVPPPPKISRTIHLSTPPPPEIYQTSREERSDYGFEDRVREERTRDNRLGEDRGREHKSREDREDRSREERLPNKRRSPSPPKSGKSQESLSIEETNKIRAKLGLKPLEVDSGPKEGGPPNLIKDDLGEFLHKPAVNAAEKAKQEKLREKLAITKQKREIQSSLAAVKTLGEGDDDDLNTEKWASKFAQIQEEKRKAAERAKMLDQMDEAFGGIGDLVKEDIHNDLKNAYTNKDLKGLKVEHSLNNFNEGTSVILTLKDQAVLAEEDDVLVNVNMIDDERYKKNVLVKSKKPGYDAYDESHYDEYGMPLGKVLDKYDEEIEGEKRDSFAIGMVDAKEIKERQVAMVKNRLANKRLESLQLAEPKIASDYYNESELEKFKKPKKKIRKLRPKKTLKADDLLTGTNDYLRDLGSRRRRHTSDVIEIDDLEGPAEDLSGVKIEEDDRDVERIIKQKWQKIKEPVVPIKPEQIALTLKQEADMTSETDSAGNIILNSTAEFCRTLGDIPTYGQAGNRDENHQELMDFEMSEVKQEYMDEEMNGKSAWNSVEMDDDSVIPVGPEAAILDAEPSLDQGVGGALKLAMSKGYLQKEDSNRPSASRFAHLKAQNYSIEDKTYGDDDKFGRRDRFSGPTSDFKEKDGFRPNVKLDYIDDDGHILNAKEAFRYLSHKFHGKGPGKNKVEKRMKKAEQEILMKRMSSTDTPLGTLNLLQAKQKETQSPFIVLSGSKHMQTASISKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFV4</accession>
    <name>A0A232EFV4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004952">
        <property type="protein sequence ID" value="OXU17192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFV4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="47" mass="5502" checksum="B1685EF6A5B9AE6A" modified="2017-10-25" version="1" fragment="single">SIIKWRGSATKASLRSRQSCGAYATIYCYIKVRIFHYKEINVFRVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG86</accession>
    <name>A0A232EG86_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004826">
        <property type="protein sequence ID" value="OXU17366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG86"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="10178" checksum="047ED013A41FA0F0" modified="2017-10-25" version="1" fragment="single">IVLCSKPARLKIYRFRLCVYIYIPEYKFCVRHDIVVVDKNKPLPFTGLQDTCSSIIYCDDLCAFKKRSDKKVTELQDSRRQKTEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG98</accession>
    <name>A0A232EG98_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004819">
        <property type="protein sequence ID" value="OXU17373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG98"/>
    <dbReference type="STRING" id="543379.A0A232EG98"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="276"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="434" mass="48510" checksum="4C46A2A85E1FDE3E" modified="2017-10-25" version="1">MAFTTNEEIKKHDADHHLCAAALTVQDNDDLSCLVDECAALTLQDGELVILHCTSEGKAVKAHKRVLARSSPVFANMLNSHRMKHRNILEILDVAYDVLVEMIRFVYAGRVGNIDALVGELATAADIYALNGLKIMCEERMIENLSLDNAIGYLHLADRLRMDGLKGRTIEFIFRNASEISDKAEFKILPDDMLCKLSIPTFIRYTSEFHAHPETRFLLIITHQYTSLNMSGIVNEETKAAEQESQEQINDANLSRFVDNFSTVCLANNKNKAAGEMIHLFCATKGKSIKVHKSLFAHKSSVFADMFVTAKKMEQDVVVIPDTEYNVLEEMVRYVYSGKVRNIDALAAQLAVVADTYGLDGLKTMCEVRMSNNFSLDNVIGRLEVAEKLKMHPVMEKAMTFIVDNAVKVSAKPEFQKLSGHILSELFSKLANAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGH8</accession>
    <name>A0A232EGH8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004751">
        <property type="protein sequence ID" value="OXU17469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGH8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="41" mass="4224" checksum="B96D6C93FC30CE48" modified="2017-10-25" version="1">MPSKALLLFGEYGSRLAIARGTSGTVGALRRYGAVGWVAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGR5</accession>
    <name>A0A232EGR5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004687">
        <property type="protein sequence ID" value="OXU17557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGR5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6941" checksum="7AFF55E94E087532" modified="2017-10-25" version="1">MQHILFRFREPLFRTSAQVCFRKLRVPGGTPPDPPQPTPILGAVNGREDEEKTRRQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHC0</accession>
    <name>A0A232EHC0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004539">
        <property type="protein sequence ID" value="OXU17734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHC0"/>
    <dbReference type="STRING" id="543379.A0A232EHC0"/>
    <dbReference type="OrthoDB" id="10007415at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06768">
        <property type="entry name" value="PDZ_NHERF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF28">
        <property type="entry name" value="GH04176P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="268" mass="28893" checksum="697012FB6D9ABCAA" modified="2017-10-25" version="1">MDHQGTPCARLCHIVKWDDFDGYGFNLHAEKGKSGQFIGKVDEGSPSEAAGLRQGDRIIEVNEINIANETHKQVVERIKAFPTETKLLVVDQQADDYFKANNLPIKASMPGVKVLKTPERSPASIAQDERDAAAMAAGIQASIPFAEYPGRLHILTILLFFSSQLQSGDTHSIGSSASDAQQENGSSGSIGVGNNGSTTRLDDDTSSNKSSSSAGKEQPQQQSNGNAAGLNLAMSAKELRAKLAMRKKYDPKKESLGFKDKFDIVQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHC2</accession>
    <name>A0A232EHC2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004540">
        <property type="protein sequence ID" value="OXU17733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHC2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8200" checksum="33A4235D32238C06" modified="2017-10-25" version="1" fragment="single">MASYAGYGTEPVKRNSLQLSAGNIVFQKTLAADTNLFGFLRPPRTRKTLVYEDTIQKCVLLGSKYQKRASICGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHS5</accession>
    <name>A0A232EHS5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004438">
        <property type="protein sequence ID" value="OXU17895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHS5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="10948" checksum="E6D742D783C61114" modified="2017-10-25" version="1" fragment="single">SLVTFWDSFLGLPSVSSQGTDLARSLGIWTDLARSNTDTSYSTTIPEKQALTLHEEIFYKRQCVDRSCSFIVSVSIHAIVMIFNTQHPATNKNLLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHY2</accession>
    <name>A0A232EHY2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004419">
        <property type="protein sequence ID" value="OXU17932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHY2"/>
    <dbReference type="STRING" id="543379.A0A232EHY2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="700" mass="87903" checksum="30FB6E5C8F5C43E3" modified="2017-10-25" version="1">MADVAKNLLTSSCNPANTLQRETSSFQPWRPWSSEPSPCQPAPVAQYPALNNPVGEFASIPANPEIDPPPYRSYRCFQLITVRYQQPVRCAELHRQQCEKLYHWCDEPGCHRETEISRGYSYGGGEQWFRDEERRYNEEVQAEHRENERKAFAAHEEFKRRYAADAQRHGQNRQYAEIQWQENKSKTFVEAREEFHKSYTEETRCLERSRQYAKAQSLKVKQKLLEDTKCQEAKEQREEETKRKEDIEQRREKEKILQRERLKWNPRRKQERMVKETKQQQDERPQTEVEGKKLRKDEQYRAEKTSRENEKGQEETKQIEYKQRREDEQLGSKEKHQQEKKLIHEDKKRREEERNRQHIEQRREKRRIKERQKRYRRQQRKIEEAKRLEDKQSRDEEEKKYREKEKQREDEQRREVQKLLEYEQYQKELKQREIEQRRVVEQRRLDNEQRQKEQRRREDEQRRVVEQRRLDNEQRQKEQKRLEEQKRLKDQQRREERKRREDEQRLKEKQRREDEQRLEEKKRREEKKRQEDKKRFEEKQQEDEKRRAERKRREDKQRTKWQQLYKEHQSEKKRHKEDLKRRIEEWKQKREKLRQEMKQEKVKDRRVKEKLRLVEKELEELLRKQEKKRILHVLRQKEEEDRLQEEQRQREFCDKLNERRIWYEQIREEMYHVSVKIEDLERTMELQDQKSAAKGELEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI47</accession>
    <name>A0A232EI47_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004369">
        <property type="protein sequence ID" value="OXU17991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI47"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8443" checksum="92075EEEC122B29F" modified="2017-10-25" version="1">MNAATLSAKKNSKPGIKSEWQRRTSKESLSMRQEYQLRQVETSLRMQLIDKKDTNDADSRNIDPGKTTDNNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIE6</accession>
    <name>A0A232EIE6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004255">
        <property type="protein sequence ID" value="OXU18140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EIE6"/>
    <dbReference type="OrthoDB" id="6119432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="533" mass="61545" checksum="6165C031795EF908" modified="2017-10-25" version="1">MQQCYCNHEDTKMREFTGTWVADELRKAVELGYRLRAVAKLCLNLFWGKFGQRSNLKQTEVVKPRESLLKLLNCPERDVNDILAINDEILYVNWQYKDEAVTPTPHTSVVIPAYTTDQARLELYNFLRRLGDRVLYYDTDSCIFVSHDDAPDEYKPFIGSKLGDMTDELCGYGENTYISNFVSGGPKFYAYTAVTPNKDDKIECCKNLINDAFANEDHESEKMNXCYCNHEDPKMREFTGTWVADELRKAVELGYRLRAVAKLCLNLFWGKFGQRSNLKQTEVVKPRESLLKLLNCPERDVNDILAINDEILYVNWQYKDEAVTPTPHTSVVIPAYTTDQARLELYNFLRRLGDRVLYYDTDSCIFVSHDGAPDEYKPFIGSKLGDMTDELCGYGPKFYAYTAVAPNKDDKIECCKVKGISLNFSNGVKINCDSIKNLINDALANQDHESEKLNDECSKIRLKFKAIRRTKMHEVVTREESKTCCVVLKKRRYLTSRSISSRESRKKIVEFHEGLPQPSDYSQDDEKKNINYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIT4</accession>
    <name>A0A232EIT4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004156">
        <property type="protein sequence ID" value="OXU18279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIT4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="31" mass="3658" checksum="AD65818969086D78" modified="2017-10-25" version="1">MRNKDDISYPQQALMSFITHDPVRYSTRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIU4</accession>
    <name>A0A232EIU4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004156">
        <property type="protein sequence ID" value="OXU18276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIU4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="17431" checksum="900D7433ABE567EC" modified="2017-10-25" version="1">MGRKQQRRRATKRVARRLAYYEKKVAELMEEILLAADERKESLISLYHEPTSPSLNSKFARPSRLPNISKQCPPPHGLTLSDSSDTPFPKEPLKEELRDDTTPEQREAVRQAFIKRYNARIKRRSDLKPDTMSIDPDVLDIQLSVSWEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ92</accession>
    <name>A0A232EJ92_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004094">
        <property type="protein sequence ID" value="OXU18378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ92"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11332" checksum="4486E203C86B1AC9" modified="2017-10-25" version="1">MSAQKLRNVVIYFPVSPFGPVNESQPVCVLVHQKPNETGMASYVFRIIVLGFFPGYLMKTSTMSLIVTFKLSNGHLDPVVKKDLQGNFKFSKILKILDVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKZ6</accession>
    <name>A0A232EKZ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rapamycin-insensitive companion of mTOR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003671">
        <property type="protein sequence ID" value="OXU19027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EKZ6"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="512"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="921"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1384"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1157"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1660" mass="186883" checksum="32935539BC8B1A5F" modified="2017-10-25" version="1">MAISSWMIWNRSLRSSTPHRRHRHDQEENCVEFDLSKDFKENIAEALSNLCQRHGVSDAKKLAYLNAIVKLVTETEVPEYGYSADELFCCLRVGLVHQATQVRAAALRAIRYMLKKEQDVVAINRLQYPYFIARSMDINIRNEMERIQALRLLRRILVLAPKHFSPTLARSLISITRGGMEEKDRAFRVFLAVLCELGVLNSNVLISCGGVGTLARAATSGQSPAITEAVVGVLLRLLCNPETRTSVSLLCLAAPYCELESVGLERSNEDWDQRFAASKHALLSVLRSYSGVIHFCHPNENSGLKAISDILYVEQLEVRGAVLELLYELLGLPLPTWTDEPDVALAAVDPSRFQNSWKLSEGFVAAEGRTILPSLTSHCPNITELHLGLLVYILLECGLHRALAETIVSSDTFISVRAAVLLGALLHLAHSLLPPEVCDMTPPLPNLLEQASVGRHQALAAVAILGRMHSLMRRRPAPASLFMDRLLQAGAWLRPTMPHNLRRQSSTRNWLRRESPMQQLLKDSQVLTNKDALAWNWAAVRSILRSQDNAFSLLHDSDHRMFIKKLIKYFKPSSNQYSRIELSTNALMARETTLAGCELINLLLEIHEPDGTRFLNELIADIADQMTSIRLAQSAHDCLFSPRHVSTTCCQKYFLFIGQLSHSLRGIATLRTFNLLEKLQDLAVTTKHDCYVKLIISSLDYMRDGPNRQVMTKVIQDSTLESTRMYATQFLRIILRARMVDAHQWAIGLLLNKLSDSSRVVALAALEVLHEACEEPEYLEVVLQKSEDKWSSNWDQWLHNLGDKGHLLKIRLYSLRSSFGNLPSAAEELERWIKPNGLAERYAGLVEGEIHDSLTRRQRGENGCYIRRSNGNSVMPKDVFVPPHLIGQLVQHDHGMQLLLRRNVLQRFARIVQRFRMECVSNGSGGQSREDRAAKEDGKVDEKKNDAEGGISRLETILDSEIADKADVHTPLKCEPMIEVRRKLSQDDSRRTTPERSWRGELDMREEYACGLEGRILKVKSALWSLGHAGTSALGVEQLTNLGIIELLTSMAESSPHYSVRATAMYALSLVSTSRAGADILTCYNWPCVRYKRGAYWPVVQPSFTSNSMPGSSQQQSASPVSVQRHHRSLSDGKPELLPEPVLRRQRNRSESAATDIEQKRYMLPERGETPSPLSSAQRLSQQDAEGYAKLRSLQRHRRPSYSHSSLEMYSLDGRLSLQSLSELESSRSWIAEIAATPTQQPTATTPEDSSSDSNPRYMGISLPRKLHAIFPEATPSEILRDKVNKSRPVFESKHTQNTSESSIMQVDTRMIARLLRPEREQQRMQEQMYEGDSDRFSPIPTIILDDRAKANVDVIASNKLSIMESDSECVLATVNIRLVLPEDSKPKQRTTSTSRQNPSDMDEESSSEYEATSDHSRICLVCFREKSVSNDSVGTDVDFRRTVDKTRREILRHTQRLANPVFSRHSQQTLLRLRQQYPNIFQDVCIYSEVASRLANNTYRITARRFLQELFLDSSFDTLYEEPTTILKMTVNAPEDSQSSNVPKTHAAVVVSPSHKQSKPSEAKVNGRLALPTDPQPEHLSVVTEETAATMAAESPSVEVIVNLQKSSTGGDKRLLAEQRRSDEKIIAEILKPEERMRISKSSDKMLVATGMNTAISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELI8</accession>
    <name>A0A232ELI8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FERM domain-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003564">
        <property type="protein sequence ID" value="OXU19191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELI8"/>
    <dbReference type="STRING" id="543379.A0A232ELI8"/>
    <dbReference type="OrthoDB" id="2142533at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051594">
        <property type="entry name" value="KRIT1/FRMD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057096">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283:SF10">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13283">
        <property type="entry name" value="KREV INTERACTION TRAPPED 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24522">
        <property type="entry name" value="KRIT1_FRMD8_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="45"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="453" mass="51371" checksum="7FFDC0D7D93EA0C0" modified="2017-10-25" version="1">MEQQEDCGRNLRNQVVCRFQHDYKHDGACPPTKQPVTQQPDRSTVCIAVYLMSEVCLTMDIERNATAQQIINTVQADPELALARTPPFTSSQPVFALWLCSSQLEVQLRPNHKPLDLATKWPRLVNKYGSQRSRDSDEEPILYFRRNVFLSRRDEEQIKEPKIMELLYAEAKKNVLDGRYPCESQARYASLGALQARIELGPYNVQAHTLAFFRKHRGRFLPHHYNSPSLLLGLGFGLGLVGGKGAPEARLLEQYKRIPNHSGTNTNPRKLVRKYLEFCWGLPCYGAAFFQGQIERPVRGLASWITNRDLPVLIAINTIGVYIVDDAQCSLLLGLRYSELNWEMAKPSDEGNPDCLPCLFLQFPVRENGARVYKILQVFSRQAIMMDTLISGFAEESRQSEAADENVNANNRLQDNSMLSNVGSFTNKLSKFTLATFDDEGHCIGQMGSWSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELK2</accession>
    <name>A0A232ELK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_014541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003560">
        <property type="protein sequence ID" value="OXU19198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELK2"/>
    <dbReference type="STRING" id="543379.A0A232ELK2"/>
    <dbReference type="OrthoDB" id="69229at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051591">
        <property type="entry name" value="UPF0224_FAM112_RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402:SF10">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="583" mass="69480" checksum="D161E66DF4C8FA10" modified="2017-10-25" version="1">MTEPSLEERQKFLDDMSKFIDDAENCMKDLCSSVGWDYNYIYNYEETEKYAICPFNDGHRVPERTMHKHLVKCEWKTLGYTKECIPLPEPVLPPDDPSTIKLDMQLQAKVLQEAKKKNPDANISLDEKFVPQTSDRLTSDFTSDERKAMYEYVIANTVGPDIGHDITEMNKPEKTLEGEIKSTPIELLLAQERNLKRRRAKHRGVHTNKKSHTEIMREIVQQQMEMYREHLSEKYGIPIPNDEANAKPSEKEQQNKKNYEDDLNENSEQSSHSKRDRKNWNSADRSDYKKRYNSKSLDEKSERVVHESRDYSSSRRYSNYNKDYDSWSSAKKHQRYDSRDKYRDEHDFRDRSRDKYDSRGKHRDTYESRNKDKDRYDSHDRNREKNDSRFEDMNKHESQDSGRDINESRDANRLKYDSRDSSRNNKHDFRDKNKDKYDSRDKSRDDYDSQGTKKDKYHKYESNQSEYATYNRSRDREECSGKKESKSIVHESRSRKREKSESIVREIIKVSECEAKKSSSHKKHKKDRKREDRSRDKEDAKKHKKSKHKKTRDRSQSLSSNLLQVIWNHDTCACKGNFPLGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELY0</accession>
    <name>A0A232ELY0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003464">
        <property type="protein sequence ID" value="OXU19365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELY0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10976" checksum="32857595BDA11A3A" modified="2017-10-25" version="1">MRDLSRAEAKIFTQLITGHGTLGYHQHIIGRVNSPTCKWCNQNEESSIHVLCHCLALAEKRYRALGMTTCEPTAIQSLTVRKEWCIPPDTLILKGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM79</accession>
    <name>A0A232EM79_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum vesicle transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003411">
        <property type="protein sequence ID" value="OXU19456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM79"/>
    <dbReference type="STRING" id="543379.A0A232EM79"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF30">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="167"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU19456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44789" checksum="0B6E87F29A978CE7" modified="2017-10-25" version="1">MLRKRNIIKVVKELDAFTKIPEDYRKQSAVGGTFSLASFCIIVYLIYAETSYFLDSRLQFKFEPDVEYDSQLQMNIDITVATPCDRIGADILDSTNQNLMTSENFHLEDTWWDLTPDQRAHFEALKHMNYYFREEYHALHELLWKSNQLTFSNEMPKRDYIPSYPPNACRIYGSLDVNKVAGNFHVTSGKSVILPRGHFHFTSFHSSTAYNFTHRINRFSFGKPSPGIIHPLEGDEKITTDNMMLFQYFIEVVSTDINMLMHKSKTYQYSVKDHQRPINHAKGSHGIPGIFFKYDTSALKIKVSQERDSIGQFLVKLCATVGCIFVTNGILNSIVQNFWCLFCYKFLQSSNGKSDEKTTVDSKGKAIGNPINLISVMAPPSIDDVDLLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENE6</accession>
    <name>A0A232ENE6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003181">
        <property type="protein sequence ID" value="OXU19856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENE6"/>
    <dbReference type="OrthoDB" id="6624682at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="143" mass="15876" checksum="FAD91D6750B48E76" modified="2017-10-25" version="1" fragment="single">LFGTREPKQPREQQQQQQQQQPTSERRSHDTGQGPLQWAAPPDYRGKSAHVSPLASPNSELMTSRPRTSLPSDVVIPETGKISRSQPRGAWGSRPLSAGPFHRPNLPEVELVRVLADSQLRPEDPAVPLIAAIKKELGKFTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENH9</accession>
    <name>A0A232ENH9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003162">
        <property type="protein sequence ID" value="OXU19887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENH9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11216" checksum="4EDB745B2C7FEBD0" modified="2017-10-25" version="1">MRRRVSDRSEGGWIVACTWHSRRSRPEESGQKAQIEREIGTERASEGYYETRDLTVNAKRKEREGCHFRETTIPMDNSTLFSGASELRAALLIKQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENY5</accession>
    <name>A0A232ENY5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003039">
        <property type="protein sequence ID" value="OXU20073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENY5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="47" mass="4904" checksum="DF31E5BA411BD890" modified="2017-10-25" version="1">MNVALPLLDGLVALGITSSAPLSSRWHTELLVALGRLSLGTMSWPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP31</accession>
    <name>A0A232EP31_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003018">
        <property type="protein sequence ID" value="OXU20110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP31"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="240" mass="26751" checksum="EA485EB251E9CFAD" modified="2017-10-25" version="1">MEQPALKAMTERDETIVVLLSQADNEELQCPLCTRVGGRSQVAHPVAVSFSVATDAASPANSTLSKQLPTPAPPTNQPITDSSRPRPTRGSPHRQQADGNRDPASEQRRLVGLLEAASIREQLKESTALAMQFLGRLTVRRPATQQRERPAPRRRANNGVEAQPLDLIRGATRLQRLYRTAKKWAVQQILTGPNGICQIDKTSVFNHFNDLAARRDYAAEMVHLGYYRLLRWLINSHLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP35</accession>
    <name>A0A232EP35_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003022">
        <property type="protein sequence ID" value="OXU20101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP35"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="91" mass="10479" checksum="1009BA090217EF7C" modified="2017-10-25" version="1">MNASKANPTNGNKNSNTNGKEKEALSFTCYYCGSKGHLQPACKKRIKEKRFCNYCDRIRHTIDICHTKKYQLNNGRYNNYPNTNKGGRNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPL1</accession>
    <name>A0A232EPL1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002921">
        <property type="protein sequence ID" value="OXU20294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPL1"/>
    <dbReference type="STRING" id="543379.A0A232EPL1"/>
    <dbReference type="OrthoDB" id="112668at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19867">
        <property type="entry name" value="DSRM_DGCR8_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19868">
        <property type="entry name" value="DSRM_DGCR8_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000018">
        <property type="entry name" value="DGCR8 microprocessor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000021">
        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000051">
        <property type="entry name" value="Microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.590:FF:000001">
        <property type="entry name" value="microprocessor complex subunit DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040375">
        <property type="entry name" value="DGCR8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482:SF3">
        <property type="entry name" value="MICROPROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13482">
        <property type="entry name" value="MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="330"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU20294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="610" mass="69201" checksum="8A83C6F159C9F2B9" modified="2017-10-25" version="1">MELDVQTSDAVVEKKSEDDVNSEEMFTQEESMDTCTATLQEVQHSQSKETENPLISEDATDDDLRQFDVLDDLERHTNQDGSDSDGCSNDSMDSDIPDDEIEAMLEEGLPDEFKGKRSDRRSDMLYEEKEKLVLDEIGHNHFDVLPEGWVQVTHNSGMPLYLHKQSRVCTLSKPYFLGPGSVRKHEVPVSAIPCLQYKRALKEEEDEKQRDKERMQAAQACSLPNAKIETIQENRATQSLDGENLRNYCQSLFRFKSIKVMRFKSWSQRRKFTKNKKQRKQLERPTLPDGTKLITFPVGKSAVHSSNSTQEDESASRPPKHWIMNPSGKSYVCILHEYVQHALKKQPTYKFKELENAATPYSAVVCINDMEYGSGFGSSKKQAKANAARKTLEILIPQMRDKISGDTTTDNSSTSSSQTIKASKVNSDADLSFFDEISINDPRVAEFCAKTTEPLPHAILITCLQRNFGLGDMEINYSVNTLKHQRNEFTMKVGKHEATVICRNKKDGKQRAAQAILQRLHPHIHSWGSLLRLYGSRSVKSFKEKKQLEQEITLLQGKAAVNQPNHAILEKLRQEMRKLSDQRQAVKPIGKFIPPDMPTGSSSNLDNVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPM2</accession>
    <name>A0A232EPM2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001778</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002918">
        <property type="protein sequence ID" value="OXU20310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPM2"/>
    <dbReference type="STRING" id="543379.A0A232EPM2"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="315" mass="33332" checksum="BF8F7254ACB665C9" modified="2017-10-25" version="1">MADVPQDAPEHCPGTQSEDAGKVSACAGCPNQNICSSGATKLPDPGIALVKERLSSVKNKLLILSGKGGVGKSTVTSLVSRALAAENPDRNVAVLDIDICGPSQPRVLGALGEQVHQSASGWSPVYIEDNLSLMSIGFLLNSSSDAVIWRGPKKNGMIKQFLSEVDWGTLDYLILDTPPGTSDEHLSAASYLKEAGITGAIIVTTPQEVALLDVRKEIDFCKKVDIPILGVVENMSIFVCPKCKTSAEIFPALTGGAKKMSDDLNVEFLGTLPLDPLLARCCDEGKNFLIEMPDSPTIVALNTIVQKIVQKCDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPU6</accession>
    <name>A0A232EPU6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002915">
        <property type="protein sequence ID" value="OXU20326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPU6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="13018" checksum="C7674146E70C8CFE" modified="2017-10-25" version="1">MATVIGDTFLDNVISRDKESVDGLPLCSAARKGWQIQVCVRARQVPGRGLIRVSYKKPSILGTTPLLAWYPYLQLQPISTLFQPKPQSLSLCTIVKKDTINFELTLVVNFREIPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ28</accession>
    <name>A0A232EQ28_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_014418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002846">
        <property type="protein sequence ID" value="OXU20448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ28"/>
    <dbReference type="STRING" id="543379.A0A232EQ28"/>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="13">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU20448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="235" mass="27096" checksum="C2AA86596AE112AC" modified="2017-10-25" version="1">MTTTESKSSGSTSSLGCRICYEDGTSEELIEPCECSGTLGLIHASCLERWLSTWNTDRCEICKYGFAVERRNKPLPQSFWQWWRTRGVYGPQGVTGDAICLVVLTPLCFATTYLCGVGVTAYSRLGFWEGTGLAVLCCMLVATYFLWFFVTIRFHYKSWRQWCKRNQDVKLLVKCKLSEEERKESKKNEDEDRDGQDSEIAQRNYGFGRVFLWLNFSFAPDTEPVYNFHQQTTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERA0</accession>
    <name>A0A232ERA0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002633">
        <property type="protein sequence ID" value="OXU20890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERA0"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="116"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="768" mass="85530" checksum="BCD608F611B69EAB" modified="2017-10-25" version="1" fragment="single">RLHGCSQRRISHPHANEPRLGPRRACQFVCYRTESAAAARCLLLCAKKGVLIIAEREREPCNEVPQSKEAVGDVQVANDLRSDSRNELELGNSVVDSIRCSNDNRVEMAESAGPILHVIVVGFHHKKGCQVEYSFPPLVPGAPNECPLGWKYLPTLALPDGSHNYDEDTVYFHLPSLNDPNRTIYGVSCFKQIPVEKLVNRTSDITRGTVQKSVCVLSTIPLYGHIQVKMALITHAYFDEGDFSKVSLLEETYHHLNSCMSGDSHMPPQVFIGLSARDFILQFRHKALLLFKLLLLEKRVVFYQSPVQPLCSAILTLLSLFPGMIETGLQQAACVRPSRPMSPIPNFEESEFDSKLDSNLTETNASSNSNLSSSAAKRISEDKLDDTSYCLNDNKTVETMEGKCIDFEINATGEDCAEVFGDEQKVDMVHRVHSVNAINVGTAGEADNNLPRDTSSDALSEARVTSSITQIANIDPELCGMPLSLFTKGYLCLPYLSLPYLDLLGDVNVRGYVVGATNVLFKQKKQLIDVLVEVESARIEANDPELRRQLHLTTEDLRFADYIVRHVSEPKKDNFFDGVGWEGGDEWIRTQFRVYLLCLLRTSLQQDPRQTDHYNAAFMNAWRATNNFKMWSDLSNAEINCVEPGHPFAGQLSVQDMKLRLSHTMQNTEGGRKLNQAMASTGRAVATTGKAVGGAISQAKGAFSNWWSTLTTVQPMDNGESKACDNQQQDVRPLPDIMRQQQHTLHLVPKVNSEDLQQTTASVMDNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERI5</accession>
    <name>A0A232ERI5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002595">
        <property type="protein sequence ID" value="OXU20968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERI5"/>
    <dbReference type="OrthoDB" id="10585363at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="14111" checksum="0701BB132E35F035" modified="2017-10-25" version="1">MIQFTYPKISLIEKLIILSLLQKNNTDLNKFMNDTRVSYKVKKNILEVMYTKVEEFHYVLLDLAYQYRYIVKQKVKEYKELFNSNGIITINNAVMSKLLFRYAEEVFYKGKYDLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESA5</accession>
    <name>A0A232ESA5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002460">
        <property type="protein sequence ID" value="OXU21238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESA5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167130" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="10692" checksum="D942AB4E2A19602E" modified="2017-10-25" version="1">MKFFAVFLLLAFLAMAYAGKLPAVEQAELKPESEAEPKTAEPRDKRGLLYSAYATPYAAAYSYPVAYSAPVAYASPLAYSAYRPAYYPSYYSSYVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESE8</accession>
    <name>A0A232ESE8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002430">
        <property type="protein sequence ID" value="OXU21283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESE8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="68" mass="7443" checksum="DD8358C2655E3C41" modified="2017-10-25" version="1">MIIVVGRERAHCRLARVSCYRLSGVPVEKSLSARASLQASLYCSVCTRVPKERPDAADADKGTPPRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EST4</accession>
    <name>A0A232EST4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pantothenate kinase</fullName>
            <ecNumber evidence="4">2.7.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_015104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type II pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01002392">
        <property type="protein sequence ID" value="OXU21377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EST4"/>
    <dbReference type="STRING" id="543379.A0A232EST4"/>
    <dbReference type="OrthoDB" id="275583at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24122">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000004">
        <property type="entry name" value="Fbl, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000025">
        <property type="entry name" value="pantothenate kinase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF30">
        <property type="entry name" value="FUMBLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU21377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="407" mass="44768" checksum="7798921CEAB7F0DE" modified="2017-10-25" version="1">MRPQSCENCLNEEVMASNGYSNAAAVSAKQSKNNSPPCESGNSMPWFGMDIGGTLCKLVYFEPKYITKDEADAEVETLKNIRQYLTKNSAYGKTGHRDAHLQMDDVCIRGRRGTLHFIRFPTSEMGNFLALARSKGMATLVTTVCATGGGAYKFEDNFKKEVNLSLAKFDELDSLIRGMLYIEMTNPCECYYWADPTDDDKCQKIPYDFSKPYPFLLVNIGSGVSILTVQGPNDYKRISGTSLGGGTFLGLCCLLTGCNTFEEAIELATSGDSTKVDKLVKDIYGGDYSRFGLPGDLVASSLTDVYSFGQMNSKDRRNTVTKEDLARATLVTITNNIGSITRMCAVTEKIERVVFVGNFLRVNPISMKLLASAMDYWSKGTLKALFLEHEGYFGAVGCLLQFTGDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUJ5</accession>
    <name>A0A232EUJ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002125">
        <property type="protein sequence ID" value="OXU22011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUJ5"/>
    <dbReference type="OrthoDB" id="7700446at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="516" mass="58931" checksum="987C31F76B116CF9" modified="2017-10-25" version="1">MTYGKFEAGVEKPKQEAACIGPLQVRRDVTDFPYILAFGVMLIVWLSVGIYAFCVGDSVFFHHFRHYTMHMEFVYMAAFFHQHINQASHIVIGFVAWSAFLLAAMAILFRYTTKIFVWVTVGLSAIMVLTIWVFLIYGMDVHGFHVLDGLLLLFFITIVYGLLVYSIVQAGTKMVCKIIRESCKVMFFFPSTLALAAAQFSLQLLIAIFSGAVYMYLTSIRQFLVTEAMDIANATDEDFTSEELNETDTSAHWFYEDEIFYRNFSSPAHIPLFHLINYCGFFWSTWFLMGAGRMVLTAAFATWYQTKDKSAIPLNLIPQCFMMIMRHHAGSLAYASSPITIVPMCIVVWKYGRDKLKEMHKRPVLMISWLTIALKFSFDAMTITAINGHTFYKSAKESYILFMKHPVSYLAMNTVTEYVIVLGTILHPILSMFSVLGYISIFDLSDYKWGVAPTAVLVVSMIAMFMSISFFMVFRSAANTIRHCYQEDAKANHESEMNLYQVQVDDLSIDDVDQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUL4</accession>
    <name>A0A232EUL4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002112">
        <property type="protein sequence ID" value="OXU22048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUL4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="23" mass="2675" checksum="07BCAF7904055C8A" modified="2017-10-25" version="1">MSLFSVKLQETTLLLITLGTRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVV9</accession>
    <name>A0A232EVV9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001942">
        <property type="protein sequence ID" value="OXU22490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVV9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012285617" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6656" checksum="AFA887EC956ECA99" modified="2017-10-25" version="1">MGGEKFKSSFMSLCVCVCDLLALRDSKEPPIHKADKFNFTIGQRVSRGETEKHTIEPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW49</accession>
    <name>A0A232EW49_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001925">
        <property type="protein sequence ID" value="OXU22546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW49"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012579191" evidence="1">
        <location>
            <begin position="23"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="408" mass="47314" checksum="644E490C91B54500" modified="2017-10-25" version="1">MRAGTKLIGSLVLLNLLLGTRSQEDRAFKNEWSGEVVRLKKSYHLQLSSNYPSSAWIFWRNDGKEDNPYLAVKRYSFDGAHYGTCEVPLNCSTYTLFYLTSLFSLDNDTEVCSVLKYQGSEIEYSGIYVINMTDCRLTSVESARDYHADYPIFAYDYHRSEFEVFHHADERKQRLCDGDVCRQSFDLARSHMSRPEPFELSRRDRPHLFYVDSVGRRSSDDGYYFVIQYGRLYYGGMYVVSTSSSGESLGSLDIYEGQCEQCAKDVSFDHNLFGTCFVAEKHPATVKCRQIDPRTKVLMNRTYDFAHKVHHLSMHNVRDGGYVLLVRYCVNEDCKKIRSHVTKASLDGVDYGRHVEFRVEQDSDCEEYPYKTTVGFFEQNGQVCMMYRCFENQDNKLYASHNVDVMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW52</accession>
    <name>A0A232EW52_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001920">
        <property type="protein sequence ID" value="OXU22567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW52"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="14880" checksum="BD6EFA054FCB57BE" modified="2017-10-25" version="1">MRRTNFHAPYAPGISYVRCRIQNCDFGLENFVFSVYSFLIASCMLNFQANQYCEVVNETTKLILNKLERRAIVFLCYLKESPSVRHYCNYNLIKMNRKSNLRFLGHLSEKNVRKASRQRNRTNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW83</accession>
    <name>A0A232EW83_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001899">
        <property type="protein sequence ID" value="OXU22615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW83"/>
    <dbReference type="OrthoDB" id="6505219at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082216" evidence="2">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="244" mass="27868" checksum="E89BDE06A12EDE07" modified="2017-10-25" version="1">MKIATTLFLFVVVGCTWREALGTCVLESDFGFTLNCAFKKSGLFRVRNLGGVKGYVGLGFSIGDELGFRDSLTNLEVSRRRSVQQNSRNGLPVVHPNVLSNREDARQVFQQQQQQSLQAQRNRMGVPPFKPLPPGASRPMAQQPERQRLVVQQNSTANAVANVPRPVYTAQQQDDILKQQQRAQLESKIMQQQKLQQEMLAMQMLKQQRQQQQEAMMKQQQQQQMVQYPQQALQQATQTRRVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWM8</accession>
    <name>A0A232EWM8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly 2 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">HESB-like domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_011867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer; forms a dimer of dimers with IBA57. Interacts with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57 complex; [2Fe-2S] cluster binding is absolutely required to promote the complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001838">
        <property type="protein sequence ID" value="OXU22754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWM8"/>
    <dbReference type="STRING" id="543379.A0A232EWM8"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="10">
        <location>
            <begin position="58"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="164" mass="18055" checksum="16CF5D639EAE7A55" modified="2017-10-25" version="1">MSIYFGMAKLTRSVWGLSSNFSSNQYFSRLLATPWISASDLRLRNSSTKVASSACEDEILISDSCVKRLKEITEEGSCLRVTVEGGGCSGFQYKFNLDSSINKDDKVFQKDGAKIVIDSTSLEYIKGSTIEYHTELIRSAFRITDNPLAEQGCSCGASFAIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWP5</accession>
    <name>A0A232EWP5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-and gamma-adaptin-binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001839">
        <property type="protein sequence ID" value="OXU22751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWP5"/>
    <dbReference type="STRING" id="543379.A0A232EWP5"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31376" checksum="F33074DDDEC91A9A" modified="2017-10-25" version="1">MEDTSTDMDLPRVLITSLQNEKAKEIASNMGAKYLSQQADIEHHLLDIDNKYYTAQILLCTTKNLSIDPTNYEAMIFYYEIETEDALHLVEEQVLPLLAQSEAEILLLVCNSIPNTAIREKVIEWCALRKFELIELEHSDPQDIMDLEEDQSKYGIDRIIEALETHMWPNINLKDSRKTNIQEPEPEVNEVGDQLENVRINNAQDISERLQMESVLDGIMNNEGADFGELFSHLRAMKEHAASMPSNQRRVAAEQLVTAFWKAIGGDPSEVDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWS3</accession>
    <name>A0A232EWS3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001824">
        <property type="protein sequence ID" value="OXU22800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWS3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="159" mass="17786" checksum="C75549A0E8753193" modified="2017-10-25" version="1">MTKCLLVMRASLLTSAREHSHHVGSERGCQFQRSGDLSLLNAGMTENTRQTRLPALVKLPPPPPFLFREDEEKLQFFQAVEPPAVSVLFAKRVSSVQADIANLSGIVTCHRSSRAEDDSSQRGVVSQTHVSAMRAVRRVCDKSPQSCSTMHSMRWHRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY79</accession>
    <name>A0A232EY79_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001638">
        <property type="protein sequence ID" value="OXU23351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY79"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="21065" checksum="0CECB25F6D5B405F" modified="2017-10-25" version="1">MAGCCKAFNKAIALVEKRISGLECSLSVQEGLSDQLLGTTTVRKCLIILYYHKVEAPIPLRNERGARVSGCGRGRGRNRVGGRGLFRTDAIEAAPNPLNVLRDEEDSPAETMEANVEVAAAKEALPVEEGQLRPRIGGREGERGRGRGRGHRRGHGRGRGRVRGRGREEGRRTEGIDAVEAVPPIAADHPLENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYF9</accession>
    <name>A0A232EYF9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L antigen family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001584">
        <property type="protein sequence ID" value="OXU23526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYF9"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10081" checksum="41679820CAF19568" modified="2017-10-25" version="1">MSDLTVDLSIPFPSEREADVAYQTLRVDAEPSRSGVKKTLTLESNTLKVNFAGSEARKIRVGLTSFFEALLLVTETMKEFGPPEPKYDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYN9</accession>
    <name>A0A232EYN9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Catalase</fullName>
            <ecNumber evidence="9">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_005131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01001595">
        <property type="protein sequence ID" value="OXU23481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYN9"/>
    <dbReference type="STRING" id="543379.A0A232EYN9"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="127"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="604" mass="68284" checksum="533F3F6605320E61" modified="2017-10-25" version="1">MFVCISRFQRYLLHYVVERQVATAAAECPHYWPERVSKSNKRSYYQSCLHRLQWHSNSSYVPVCASTVTNNKPVEYFTGCLLLNRISATNTSSRGFAHEAATMSRDPAAEQLNSYKKSVKGDPPTLLTGNGAPIANKKAALTVGPRGPMLLQDFVYLDEMSHFDRERIPERVVHAKGAGAFGYLEITHDITKYSKAKVFSAIGKKTPVAVRFSTVAGESGSADTVRDVRGFSMKFYTEEGIWDLVGNNTPIFFIKDPMFFPSFIHTQKRNPATHLKDADMFWDFITLRPESTHQVMILFSDRGIPDGHRHMNGYGSHTFKLVNDKNEWVYCKFHFKTDQKIKNLMSDKAAELSATDPDYGIRDLYNAIAKGDYPSWSFYIQVMTAREAESFRWNPFDLTKVWPHKEFPLIPVGKLVLDKNPENYFTDVEQAAFDPAHMVPGIEPSPDKMLQGRLFAYGDTHRHRLGPNHLQLPVNCPYKRDGFMCLNNQAGAPNYFPNSFSGPEECPAAKAPSFHASGDVERHEPVNEDDYGQASLFWRNVLNAEEKSRLVENIVGHLKNASNFIVERAVRNFSNVDVELGKRLTEGLRKAGLQINVSGKSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYT7</accession>
    <name>A0A232EYT7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001589">
        <property type="protein sequence ID" value="OXU23503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYT7"/>
    <dbReference type="STRING" id="543379.A0A232EYT7"/>
    <dbReference type="OrthoDB" id="6780556at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="425"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="470" mass="54924" checksum="12E2EC52E159FC95" modified="2017-10-25" version="1">MPFGLNIIGNTSDYTPDQLDFISMTMNRKLKKLESFKLINFYCPNCNKSQPRSCTDGSAIKSCSSCGQQLRYQCSRCPDKVYSVLASAQRHVHGECVNPIKLSCFLCDYQTARKYRLITHIRNKHSHENQGQPMKKKRIKKTTFKRWKLGRKCNRGETKRTLAQNDSQKKSSHQPKASTDDEPVNVIPEVHYIKEEVVYESDDSNGFNKNPETLEIDVQNIQDKTLKNILMGQPSVMEGEEVTEIEEVFVEEFEYRGPSSPSDEMLNVYCELCGRTSKKPLDYDADCELRCQDCENLLQFQCMKCNRLYRMHDSALSHVRYSCPSATTLYCSQCEFRTNRKRNLQIHIKNAHSDPSTENQHQCKQCQKKYKRRKHLQRHEKSCGKLPHIPCRFCSYKCKRNDHLLQHMQHRHPKRGVKPVSPMAYSCSKCDKKYKYQTSLRDHEPYCKGRVKQEPVDEPDKKKSKRKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYX7</accession>
    <name>A0A232EYX7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001575">
        <property type="protein sequence ID" value="OXU23543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYX7"/>
    <dbReference type="STRING" id="543379.A0A232EYX7"/>
    <dbReference type="OrthoDB" id="7412264at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03449">
        <property type="entry name" value="R_hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="256"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="498" mass="54475" checksum="B17D093A23BA18D4" modified="2017-10-25" version="1">MFSTKEQLIKKTGKHGIGRLSFLEQLVNEYKTTKSRDHKEQVLANLANFAYDPVNYEFLRRLKVLELFMITLDDSNPRLVEFAIGGICNISVEPYSREYILRNHGVRLISNLLSRSEEHIVISALTTLLYLDAKQSKKEIASPTNVKQIQKFANGTNKRLKNLALIFLEEYCGIKATSTSNSATESNKQTSTITSTAATETASKSANETLSADSTIAVNTSASGSKPSAKKYCTKVSSGSPTEALENLKIGNRVSIQRTVTENDVLGFAKLTNDYNPIHINSTRNIVHGAFLNGLLSGILGTKLPGPGTVVVEQIIRYPKPCYVGDTVEISVEITSAMMYSSTFFVLLLISIAHALDDNSITESSSSTTVTTETPVSSSTTEAPVIACTCGVFLSGQFKKGSKEQPKGNAALLHDQSDTFPCSNVGNKMCTNKCLDVIVKHLPNSPSILCGSIDRDCHKERAYLFIKNCKDEWINTNLSAGREYCCKDGLPYKCPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZG9</accession>
    <name>A0A232EZG9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SZT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001537">
        <property type="protein sequence ID" value="OXU23660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EZG9"/>
    <dbReference type="OrthoDB" id="43547at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033228">
        <property type="entry name" value="SZT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14918:SF3">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN SZT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1801"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1937"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2787"/>
            <end position="2806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3107"/>
            <end position="3139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3162"/>
            <end position="3193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="984"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1817"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1830"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1938"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1952"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2794"/>
            <end position="2806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3107"/>
            <end position="3123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3398" mass="385443" checksum="FD57DFE71CED9C49" modified="2017-10-25" version="1">MDCSENEKPTVLEADTVYLLMKKGFPISRNVRAQWVLQHLDTVIAVQNPALDCEELPDLEIVSVLPKDGIDSWCPENSYQFLYKVTSSTIIKFLAHRYRMVFSLDLSPSLATVDIQHGEIVIDEVFTSTKRCLEGLTRPFVVPGSKRVIHPEIYVTVIVHTPFFTNPAQQVLVQGWLVTKENVASLMQTIETQLNLLEEKVAQVTSLVNLQLETLRAESERLVGGLFEEGGTSIGKSNLNNNVSTIAMVLPETGFVNMLRYGMLALSLLPEHSCALTDGIVGVNDVHALESIIQQLRATTVACSFLHVGSSYHPNSANGLVPYPDLLRFFATATLGSYMTVFPATVVTEEMDMNKYHIELLCWQLYRTNHAEVASVGPNAWHTKNSLFYGHEPPQLLRKKQIDDQVTCTLNSLLCCRLREGYLIKKTAIRDGCLEICFVLPWKTHVYVEYVVTCPRFLKSLSVCNTLQYTITIEAPYEFLHDITCLSKKPLKSQYRQNMVSRFWSALTSLTESDSMLVHFSWFPGMGWTWYNVPDTIRSGMPLFYLPTSSSSSIQLSKQITYSYLNQRSDAACPQFGQIWQPVVSLEPHQWPRWLHSQRVTLILLHDRPLSKHLHQANQSGRFQSVQYRQAAAVLYGMLKTWATFVLVENHTYVQFIHKEADKPPISFSLINISCKALCVVLNVAFAGGTEGVVRHNVMTDLLERLSQLTLPSRRTEQREVPCCIILHKALEKILIRYERMPIDLSTVIFPDGSQIMSRNASIAGGSLTTTLSRYLYHARWLWLLKKPSLQTVPVITLPRLNVAAVARILSTITKIRLAEGFNFAYSAAGIINTVMEVQMKGPGSDDISYPCIVQYILFPPHVIVGPGGLEKESGSDEETDEGTADGENGVEDTETSGDFQIVMEVWIEPQCGYVQTTAAKKAAYMHFLEYHQLPEAISKIDKECINALLTLEHLSMMCQVSPLDKSHDLPGNQQQPQSSGLPTNQTSNNSNNNNGLNHGKTSRRPTYADILENPLVDDRIRPMQFDFDALGILPKCQQAELLFSMFADDYHDQLHVDNNANRILMDGLLNHIKSLHNKELILSAAESDRFTKMLLERPREDGARPQFCHYETSLLGSSKGVLYPRWRCFIKGISVTHVIVTLLPAAESDVQLMSHPDEDVDRQVLTTPVFSQQPDESTSEHIEYKQIYGDAETSHSGDTSPVQRNRAETAESTDIEYLKNALAFSTPKATDLFDKIPATASASADGTSRRGLVLPVYVYDCSLALLIDALIEKHEKPRFKDIYRDHTYRVSDNFREEFVNLKSGDNTKPSSPEPKSEDSDNVSSGDYGRTSNSLCFRFAQEDQRNLMEHCKVLSLAHCNSYVVAVYKSLILQQSISYDDIDAAVEQCEEFLMEINITDYLKAVCRHLSPQNEHDAESPCSEMRNIHNLIKDKFRKIINVAFKQVPVHPDFYYCLPAWKSCDELADAATQASSDSDDDVRFTFNSEAINGKIGNSLKKVNHISSMPWVGGSLIGHERFMLSDCSDSADSFGSDLQTDPEHNREQPLFLQLNCSIHSKSSFSTTAVKLLPTCFTEVTQKLQDFNLKDTSSLKVTLDIICLNLPKDVLEVSIDNTPAGLRTTSYCSEGSMTRADTNESSFDRLQSVEADHIYDGLNKMPRHQGNAVSNLVDEINWLLRDETAAVLLDKPSPTEDTLNFVAKHVAESNNRASCYLDKVPLHFVFSSDNSLPRFVEELKKLKIDRYCIKQEGGFFYFVKNSTDEIASDADRVSLSDFHTKQDRKGFELNSSSVFNSDDFPIATSSRVKKQDSGDPPGCHSEISSIGDNQIGTDDGYEGDSSDSEDECQWLIDLDRRRELLPNFWLILHVENNHVNVYFHCRFLELTSPEVDRYQQVQKTAVARIKAICRRVNQYLLLRDLHDKRICDPLLEPESIEDHSWKSAENNADSSVSATHNQSTSNSSGSNVSPGMFRCPIVWEVPFCLHHRLKTGPGKTGLSRGIKALQAVLNRFSVNNRSNMFVYQESNGNVFYLRLHERTSDDRPLQSSKLSESDEKLMVSRSSSIASLSQAKSLGVSVDLNSSSSTSTMDLLRPRVRSFGERESDILNKSGDSIVLMVHGISEAGPEVRYELVQVLQNRLDDAVLEVLSVMLARNPMCKLTPSDVHFIQRQYRVPESVIRLSVQQRCLRHMGALGYYLRQNILQFLYTPKYTDTRAHSHFQDYSQQDGSSKRVPESDIFLYNQSHSSGSRGIACIAIAIVNERGDIIVTENENVFDSMFPSCPEIKDFEDIVATNVYWGLNCIITKTRKLTIKFLQEKNDSKSGTKAYIEFRIWKQGRVNLEALVHKLKAAVKHANWDLITEYNFLPTPLTESFNDENDTDDHNIRNDPSELNSYELGEKGKLKEVYHTTLPYWFQFALDLAAPSMKKHIVKLERRHSLPVILKELQNLVHSHALDTTARTFVQWSRQPFIDADSTQDDLLLSKTIENVEGSIKWLQKAIEQKTADDLIFLPRDATKEDQGTYVRSILIARNFNQWKASFSSTILSEQLIPKDQKLLQKFNPLILEKTFVPRQRLLLAKVQSEHILLYMYNWSKERSEKLIKQVSSLGLWLSSRSNLYSNIIMQKLGIFHHQPVRNYEQEEQTGQQYYQITDMESLSKFPNGTQADSKEWQRVNNRGQSGKNMVFSWNQLMGQVMRDAKPSGQYPANTTDPVVKAAYDFQELRHKEKKSKDDLNKLHTMWQSRGAVPNIPISVATLNTFKQHSRLIHYCHTPLLFLPSWRLESAATRDHSLTPPPFNLAVNSQQRSRTTSDASNKRIISKWHKEICELMLAEYKQYLQVLGFNPIQIETQNKTDGENILNQAFYLKKSMLGGVLLFEIHLAEPFFVVKLRVIECSRLQAKSSSALVNQFMLSFVDACDKIKISMHLHSFTYDFHLRCIHSYISGNCHWSLRHGYHLTNFLDDFNKYYSKAPNYARNLIYSGVVTVSNLVTPAQTLYQYLLSHEKTYGMQVFSMADETDDTQHSEYVLVKLQSTPLVSYHDSQDTKYTDDFDVALIVTWTEQFAQCDSREITLKYYLMLTSKRELHPKREVENNNKIGKFRTVYSVVKSIASSQMDSPSESSPSSMTSPYLHKQTKSELVSSSSDLHAEVGNSRWDTNAAESLGSLRECDGLDSEDPENDVRSPLAPTPPPVPDSPLATNVLNASTASSSNLTQIRQESINYLGYYSSHEQLMQQLIMSQASAAQQHIKNMIEQGALHCRTHLLWNRLLESRSSMTYAEFAELRSLACVEPLSRIDPRLSPLINQPIGWYQALAKLLQNKYQEYHKQFNAPDGNVMHHLILHPNYVQAFMMLTIDLHTSRGELYAVYRKSEEITSTPFTIGDIYSLIEDFVNACCFHLWVGLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F053</accession>
    <name>A0A232F053_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001412">
        <property type="protein sequence ID" value="OXU24064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F053"/>
    <dbReference type="OrthoDB" id="6350276at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="267" mass="30482" checksum="227BB810CF0E5D9D" modified="2017-10-25" version="1">MISSSRKARRVGDYLKQDKLIVWLWISGILLTLVSSQDNFYTSGRFGKRKDSLLMSQIPLGSKFDRNNLKDSSLFSSARFGRSEDRNTGNSLRDSSSFFPARYGRSEDRSTGNSLRDSSSFFPARFGRNEDRSTGNSLKDSSSFSPARYGRSEDRSSGKFFSPGRYGRSKGHKNPKELSKFFEIKPRVDQFFIGSRYGKRSSSMLEPQAPLEALNYQRFEAAIDYLDRIKQDLAEAEEIEDETRNASRDDELVEAIYPYNYTGLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F059</accession>
    <name>A0A232F059_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001486">
        <property type="protein sequence ID" value="OXU23808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F059"/>
    <dbReference type="STRING" id="543379.A0A232F059"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="301" mass="33855" checksum="EFEE696863648EFB" modified="2017-10-25" version="1">MSNVIVDRFSPSQQPSRPSSSAIASRPHLQKRPHSKPNNSPDQDYHDHQQQHHSSQNTRRPQNGIGSSYLEKRPEEDRHHSSHSHHHHHHHGFKDKTSNSHNTLLVRLPNKNSNGQQGQSSKNQNQRPHHPRPGYGPRPSYQDSRPEEDGKTDEQAQDLTVQETVHRPSINSVDDNLSTIDFTSRTSKCIVSNHQQLRLQGASEKLNNPNINLIHTERPQWATKPASLHGRPTALEYSKPYFSVKTTPTSTTSTTTTTTTTQRPSHLAGHSSKPTTTTVSTSYYSGQSTSHYTENRKSGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0C9</accession>
    <name>A0A232F0C9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001463">
        <property type="protein sequence ID" value="OXU23888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0C9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="204" mass="23216" checksum="42B21293D16621F1" modified="2017-10-25" version="1">MRTIYLHPSSLTTRQKSSKSVCLVRATFYSTTSLCSTENASLFLQLPSKKLILGACYFQPKSDCTFFKEHSICVEQLSLRFKDHKFVIACDFYLPYLSSAEYTCSTYFTLKHIQHLPFLDSKGYSLDLLFAPNELVPSLDLQSIAHFTFESGLPSYVYSGENYAHDDMSISSAFLSHFALVYTTADLARCDDLEPVPSFLAWFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0E9</accession>
    <name>A0A232F0E9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001386">
        <property type="protein sequence ID" value="OXU24154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0E9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="7863" checksum="947496F94B647CCA" modified="2017-10-25" version="1">MLSLHGSRSGQHAPNKLRLSKPNRVRAGKSRLFLAPLSLQLPGVSTRGRGKVILIVSTQVATHTTRPTRHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1T8</accession>
    <name>A0A232F1T8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001284">
        <property type="protein sequence ID" value="OXU24493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1T8"/>
    <dbReference type="STRING" id="543379.A0A232F1T8"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="901"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="PPPDE" evidence="11">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1251" mass="138156" checksum="3F5749FF5C2D1EE1" modified="2017-10-25" version="1" fragment="single">GFPTTIVASLRSPGVATAATRLLWSGLILRAENMDDADEMGTTVELFVYDLTKGMAAVMSQMLIGRHLDGIWHTAVVAYGREYFFGPLGIQSVRPGGTELQEPQKVEKIGQTYLPYSVFWEYINGLGTSKFAPGTYNLFKHNCNCFTEEVSNFLVGTGIPKYILDLPEEILQTPVGQALFPLIENLSKGATAGFTVGQRFVEARIHREDSPEYQSLNSEIEQARLNSIALEEKRNVINEKLAKKERKKKKKDKKKRDKSSRESGSESNSTGPTNCTAMADGESTVAEMPSHANGDAQGAEMLPSDRILEMEAEEKREQEELKQRRDPPIVFRDHVDPAAELEQFRLLLQGKLDENEMLSVDELHQYVLENEGSWALGDNFLNFVGRVFYDKTLDSKARVCLLNILCIAALKDDVILLLHQDRREHTIMNFAYDIDRHPLEEQLPLAQFIANLFENLSSSEWLMYISEWQHQNQSISNIRVTTKVAVHSLLSESEDLQTRGTAIIHNLACKEKMNKNIGLRQLLPKGSISKVFDDVAVELTMALLQYFNGTPAEEQLYACMKSLARFTQISGQEVPQLIQMIGPEPAKFRGCSQRIDELIDQINKKLLTSKDSKAHAGPAPKRRRIKVSKYAPIFKWLPKYNKYRAVSDAIAGITIGLTMIPQSIAYATLAGLSAQYGLYSSFLGGFLYAIFGGVREISIGPTSLMAILTLEFTKGTNPEFAILLAFLAGCIELVMGMLDLGFLVDFISLPVTSGFTSATSVIIIVSQLKGLFGLKIQASSLLGQMYKIGENLENAKMGDTIMGLTCIVVLLCLRKLKDVKIADTSLRGVIISKTFWFLSVGRNALVVLTCSVISFYLHQGGQTPFALSGQVRSGLPGVAFPSFSTSVNNQTYSFVEMCSHLGSGIIIVPLVSVLANIAIAKVFASGSVNASQEMRTLGICNILGSCVSSMPTCGAFTRSAVSHASGIQTPFAGIYSGWSFFCPSSVFQPLSIIAELFHLTPGIMTILALSFLTPYFFYIPKTVLSAVLISAVIFLMDFRIVQQLWRGSKRDAVATIGTFIICIVFNVEAGLLLGIVSNIVYLLYLSARPSIVDTECTANMEHKYLLIRPDVGLFFPAVDFLANKITDIADDRAGPNVPVVVDCQRFRGIDYTAVKGLEKLVKDFNEKDLTLWFINLNPKVVKSIRTLGDLDKFKILKNEAEVVALLCGLDKENSVNVQIVSENARDIPMKILPSMPEVESLLAKGSNGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2U2</accession>
    <name>A0A232F2U2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001123">
        <property type="protein sequence ID" value="OXU25051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2U2"/>
    <dbReference type="STRING" id="543379.A0A232F2U2"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189573" description="UDP-glycosyltransferases domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="983"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1049" mass="120963" checksum="C6F0582FD789948C" modified="2017-10-25" version="1">MKVTNVLLFLATIGSMEICSGYRILGIYPVPIRSHFIIINQLLKGLADKGHQVDLISIFPEKEKLHPNYTQIITLPGELSEIIPRMNIATARKFGWDLSSVADFGYKICENIGNPEFLKLARNPPKDPPYDVIITHMFSYHCYAVLGHLWNIPVVLVSTTSLYPWMHAMIGNPENVAFSPNNLIPIPEGNSFWTRFYNTYVFNMLKFSFFYYSTNQDQLLRKYFGPDVPSVREIERNISLVLMNTYFPINGVKPMTTNLIEIGGLHIQNEGPELEEKLKKWLDESKDGVILFTFGSMMQVETLPKETVEIIFKTLARVAPIRVLIRIAEPQKLTVKVPNNVYHLPWIPQQKVLQHRNIKLFITHGGLLGTQESIYYGKPMLCLPIVADQWTNTRNYVSKKIALTLELMELKQEEFDYTVNELLNNPTYSENTKRLSKLFRDRPQSAMDTAAFWIEFVVRNGKNTMRSPVLDLTWWQVALLDVVLYKQQNRLKGKKGKLYFVIMSLNKTLLFVLFIKLISLSYGSRILAIFPFHGRSHMGVLEQVAKVLAKQGHHVDVISHFPLKEPFPNYTDIIALPKTGTYASMHFKTLTSTENRSDWIYDKMRNMCDYLGTSEIQELVKDQRKNVTYDLLLVHYVCGYQCFSAIGYILNLPVVAVVTTHLYSWMNTFVGNPLNLAISPNTLYGFEKKEMNFWDRLNNVVETYRSIHSYYGRADEQNYFIKKYLGSDMPDYHILERRTALIMSNSHYSYNGIMPKTPAVIQIGGIHIKNDTTKLDENLRKILDSSKDGFVYFSFGSMTLIETFSTEVIEKFYLTFRNLAPIPVIMRAWRPELMPKNLPENVFVYSWLPQQEILQHPNIKGFVTHGGGLGTQEAIYYAVPMICIPLFAEQIFNCDTLMKKNLALKLNYDTASQEDYEYAFKEILSNRVYKKKALELSAVYRDRPLKPSEEVIYWVEYVIRYGANTLRSPAVNLRWWQAELLDVYFFIFMCIALALGIGIFIAYKFLTLLSCRMSRNTKQSKAKHSNGTTASFNGKLNGTKPKSTSKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3K8</accession>
    <name>A0A232F3K8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01001048">
        <property type="protein sequence ID" value="OXU25344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3K8"/>
    <dbReference type="STRING" id="543379.A0A232F3K8"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="160"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="436"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="541"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="893"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1116" mass="126076" checksum="5CEE4718CC9D96AA" modified="2017-10-25" version="1">MKLKNPKKDIKSKKNEKTTVSLEESVESVTKENNQIQHLMAGSNKLIKIKRKLKPVTDYTTTEATTTREPTTEIPFDPVYEGTTVPHTTLTPSTTNISAIGYVTIEHIPLSTSTLTEIDNVEEEETVSLTSERNVMKERFPPRRFPEVQRALGLGQLGRISQGGFPYWLLNLVPDIKLRTNDTRYFEYAEEYLNQLLTRVKPLLRGNGGPIVMVQVENEYGSFHACDKDYMTKLKNTIQNHVGTNALLYTTDGSYRQALRCGPVSGAYATIDFGTSSNVTQNFNLMREFEPKGPLVNSEFYPGWLSHWEEPFERVETLKITKMLDEMLSLGASVNMYMFYGGTNFAFSSGANIFENYTPDLTSYDYDAPLSEAGDLTAKYHEIKKIISKYLPIPDIPIPIASKGNYGTVTMRPILNLFDPQARTLFGTVSVQAKEPPTFEALNLPNWLVLYEANLPTTETNEDQATLSAVPKDRVLIYLDGRFSGTFSRTHKAMNVALKVDGAKEVKLLVENQGRVNFGDIDVEDFKIKNYSFAIDYENDQFLLDGKPFRYVSGSFHYFRTPRQHWRDILRKMRAGGLNAVSTYVEWSMHEPEFDQWVWNGDADIVEFIKIAQEEDLEAFLIGYYLESRISNCAPKMNVGYVFYAERFLNEILRRTKPLLRGNGGPIIMVQVENEYGSFYACDDQYKSKMYEIFHRHVKNDAVLFTTDGSARSMLKCGSIPGVYATIDFGNGANVPFNYKIMREFSPKGPLVNSEYYPGWLTHWGESFQRVNSHNVAKTLDEMLAYNVSVNIYMYYGGTNFAFTSGANINENYWPQLTSYDYDAPLTEAGDPTPKYFELRDVIAKHIPLPNLKTPAVAPKRGYGVVTMTSKVDLFSKAGRNTFGTVRAEFSKPPTFESLGQNSYLVLYEADLPLIEKPENVTLVAVTKDRALVYLNNNLAGVLNRMDKTYSLPLSAKNARDIKILVENMGHVNFGSIDVEDFKGIFDVKLNGSPIASWKVTGFKLASVIDSDLGVKETSGQTGHLHNGPQFLEGHFVIDGELFDTYLNTQGWGKGVAYINGFNLGRYWPSLGPQVTLYVPATYLKKGKNSLVLLEQDYVPQSRSVEFQTKAILDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4C8</accession>
    <name>A0A232F4C8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HID1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000980">
        <property type="protein sequence ID" value="OXU25634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4C8"/>
    <dbReference type="STRING" id="543379.A0A232F4C8"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="777" mass="88119" checksum="B5218B7258C530B6" modified="2017-10-25" version="1">MGNADTKLNFRKAVVQLTSKTQVIDASDDAFWDQFWSENVSSVQDVFTLIPASEIRILREEAPSNLATLCYKAVEKLVKAVDSSCRTQSEQQTVLNCCRLLTRLLPYIFEDPDWKGFFWSSLPGKEDEESVPLAHSLLNTICDLLFCPDFTVVTNRKSGPDKAEELQSIDSCEYIWEAGVGFAQSQPRHPVLDSNRTELLKVLLTCFSETMYNPPTDLSVAPNKWIQYLTSSENRHALPMFTSLLNTVCAYDPVGFGVPYNHLLFTDSLEPLVDVALQILIVTLDHDTSCGANMEEGAVGDNLFINYLSRIHRDEDFQFVLKGITRLLNNPLMQTYLPNSTKKVHFHQELLVFFWKLCDYNKKFLYYVLKSSDVLEVLVPILYHLNDSRADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYTATVPMDIPVFTGTHADLLVTVFHKIITTGHQRLQPLFDCLLTILVNVSPYLKTLSMVASTKLLHLLEAFSTPWFLFSAPTNHHLVFFLLEIFNNIIQYQFDGNSNLVYTIIRKRQVFHALANLPSDCNTIAKSLSKRQRKHMPSSRSTENVNETAMEGSHPAQPAEPGTLKASLLETPGIENMTEKESAHPLSPASDVDVSKLNLGAEEESNDQTEENKLESIIPKGGLRVAEQSNSMNSINQWVPSADWVYQWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILKFLQHGTLVGLLPVPHPILIRRYQANAGTTAWFRTYMWGVIYLRNVEPPIWYDTDVKLFEIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4D2</accession>
    <name>A0A232F4D2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_004887</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000967">
        <property type="protein sequence ID" value="OXU25686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4D2"/>
    <dbReference type="STRING" id="543379.A0A232F4D2"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052454">
        <property type="entry name" value="TMX_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107">
        <property type="entry name" value="DUMPY: SHORTER THAN WILD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46107:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601816" description="Thioredoxin domain-containing protein" evidence="14">
        <location>
            <begin position="20"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="219"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU25686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="282" mass="31798" checksum="FC1BF255087EF0BE" modified="2017-10-25" version="1">MSRVVRSIVVLLVLALAGASIQKKTSWVDRLDEDNWDRMLTGEWMVEFYAPWCPACKALEEIWESLAFQKKELGINVGKVDVTDAPGLSGRFMVTALPTIYHVKDGVFRQYKSPRDKDSLVEFVSKKTWQKVDPVSSWKSPTSIQMSIISQFFRMSQVLRGIHNKLMEDFGLPTWGSYLIFAIATIVLGAILGLLIVCIIDFIYPPKDLMYQVKKKQKGDSGGFMTEKSSGDDELVDGVKDDLVDEDGSDSEEKSENDKTDKESKSSPNSPNVRKRRARKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5R8</accession>
    <name>A0A232F5R8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000860">
        <property type="protein sequence ID" value="OXU26176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5R8"/>
    <dbReference type="STRING" id="543379.A0A232F5R8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="13439" checksum="9A9B8D9019C4ABDC" modified="2017-10-25" version="1">MGTFYQAEVKRVGDTLLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F649</accession>
    <name>A0A232F649_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000824">
        <property type="protein sequence ID" value="OXU26314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F649"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="205" mass="22591" checksum="9A71DE31EF54B476" modified="2017-10-25" version="1">MHIDERAVGARQNLHQDTTSDDKIKMMINDNASLTEQEPADTSDDTSKVDESSAESKDDAFVDIYRCFAFSSNQISILPQIMSLYRRSRFYESLIDRSARQKENEASFEDIYDGSCFLVAQVFLLICLVAPGVTEVLILISSPQPRGAVALQAFFRKPGPVFSNRDAACCLLRHRSAFSCFILISSVTSLAQQCVASAVSSVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7F3</accession>
    <name>A0A232F7F3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000811">
        <property type="protein sequence ID" value="OXU26373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7F3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="20" mass="2414" checksum="E0C19B55E3452EBC" modified="2017-10-25" version="1">MALRCMLCQWTDLARSKHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7J1</accession>
    <name>A0A232F7J1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000777">
        <property type="protein sequence ID" value="OXU26562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7J1"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="8">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="174" mass="19551" checksum="A878CE87CA3331F5" modified="2017-10-25" version="1">MAIDRRKEDKAPLLVDEFRLEPRVMLSGEDQIDAATIEEAPKVPQSRSDEGPICDSTSCAKRSVVFLREHTFLKRASTRMTCPNCLRGVETIVERENTRTTHLSALLLLPVCLCILPYCSKLLRDTRHRCPECGIHLGARFASAREAFVVCLRISNAEPDEIFATNSVTEDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7L5</accession>
    <name>A0A232F7L5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-pass membrane and coiled-coil domain-containing protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000802">
        <property type="protein sequence ID" value="OXU26438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7L5"/>
    <dbReference type="SMR" id="A0A232F7L5"/>
    <dbReference type="OrthoDB" id="7634424at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027960">
        <property type="entry name" value="DUF4519"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644:SF2">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15012">
        <property type="entry name" value="DUF4519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6944" checksum="24EB5D1564B0C7E5" modified="2017-10-25" version="1">MRQLKGKTKETSKQKKERKKEFLENKQRVFTLVLPTVAAIFALIVAYVYVKTRPKAIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7X9</accession>
    <name>A0A232F7X9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor of white apricot N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_009775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000808">
        <property type="protein sequence ID" value="OXU26407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7X9"/>
    <dbReference type="STRING" id="543379.A0A232F7X9"/>
    <dbReference type="OrthoDB" id="10070965at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF4">
        <property type="entry name" value="CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="4">
        <location>
            <begin position="50"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="447" mass="51163" checksum="95C3592899E8FA5E" modified="2017-10-25" version="1">MSFSVKKTGGRMWHEARKQEKKIRGMLVDYRRRAERRRDYYEKIKSDPTQFLQLHGRPCKIHLDPVIAAAGDSPANMMPWQGNQDNLIDRFDVRAHLDWIPEATNATEIDVPLTSEDRHINYERYRIIVQNEFLNVTEEKFLHQIHLEEQFGSSTKPDLVKDKKKSSNNAAIGYNYETEEPIPETPKPADPAAVPEEKEDDDSDIDLDICVDVSQIEPSQAHEMNQVAQKYGLVGADYFSFLTQDFEEAETLRQARKQEEEKAMYSGRRSRRERRAFREKKMIGRVMSPPSYAARESPEYNPYRKSSSKSRSRSASPVNAGQITYITSFGGEEEAAQSSSSQVPVTNLKKVNSTSLKRKKSVEKRSISRQEVRKIQVTQSIPLVSLLLQVKVTRPKQVTILHKNSVTFTVEVEVKIAAEDKVANTIAQPFSLKKIEIAFLDNVLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8T6</accession>
    <name>A0A232F8T6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000638">
        <property type="protein sequence ID" value="OXU27254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8T6"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14267">
        <property type="entry name" value="Rif1_CTD_C-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1642"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1922"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2054"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1601"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1642"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2054"/>
            <end position="2064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2359" mass="266231" checksum="E2B11FA03E464FBF" modified="2017-10-25" version="1">MAACSNQLQSTMKQLKDATTPDSKTLALTSLRRVQLEDTKVIKTLKDEEFCELCNSVINASITENDKLHIEACRTLDIILPETRNRNFDFFQSILQINRKKRLKILVSLSILKDETVATIASKVSILDFLKNCMQSINTASMTWLLAQNADNVVELRKMESKTLTENEEFEEKVVENTLKLLGRLCSMSSFGINVRQFDTLLMETVIILAYMGLRRQRAQALIVLKEAVQNDLGVRVRLMQKEIWDSYKSSLQNIYCKRMTLLVNINDQDWAVQWETSIALVGTDLHRGSGLVNSLLKVEELAFKSADPNRRQAFVSWKVLIDNFALDQRELATNRRIKLLCVPLNAKNSKTELMVLTKLEVWWHLIYKVYPSISECIDTVVVPFLTMCFGPFGDKPLFVQKTDTNVSLGKKFPKTQVFALYTFMQLIVDKEDCAKISSSIVVQDVLPNPVSSSVFENIYKIFIHCFGEILLSLGLLSDDDVTHKSEIYSILWDGLIKRIEEYDKMKVPMYQEVVNVIVELMKHRFYKIPMIRDFLFNKILKKFDSIANSMQFTETTLMDLVQTFLQVDNFSLFRSDHYQSIETLLWHLIKPKNADAYYPQTMEMMQAILKILDDAKNFSSNMFAACEVWCILARIAKKYIEDSQNINEGTCLEHNFKTVESIISFPFTHIFTDDHAQLRRMAESWIDLYKQFDFQAELIVTVKANEIMNKTSNMLITALKKEKKCCDLATVCIDGLLTTVNYDYLSNNKEVPAIVQLLKDLTFQCLRSKSFASDKILKALCAFLLRVFSHSAEKTAQYLKVIEPVVKFLLAEIDDNNLDREIINTWSTIVGLFKKLQKYLDSELLACYRKTIVLAVLHLSKEISSLALSLLDLKDIVDEKAKKVLEEVIYELKETSAKNSFDIDDIKEKSNKKTRSPHIKPIGSFLNRKSVSSSNARKENGKENFEKTKVINIEPDSQDFVLINTDVQLDVSRLTDHQKEMLKKRRDDIPAMYNDLTVSNSQDSQELQHWFDAKTGKSPAATVKKNNSPSNNNEVPKPTSATALHFKNIADVFNIPEKVPEKPTVPVKSASPKTQTRKQQAADEDVSAIEDSQQVKVNSAPIVVKKLDFESREEFPADSEQQVSPSIIDNSKMRRRNPTEENNGAAPETIVDKNVRTTRRSLQPQQQRVTLRKSNSNEQLNTKRGRKRRNSESNSESVLNIVHEKRSRREDTPEVLNSSGESSKSNEENKNSVQEIDGKKISKRQLNEMSRLKIDMRFEPLPSRRSAGKLTENAASHAADKKSIASKDDKSKDEKTPASKAETNQQVNSTIKRRSMSKITPFTKVETSVEKETEKHKKDSGHKKPAAPENLPENNKLTTRKSLGCKTEPIITSKKNEIVAETQEETQIKEAPTQMETDDNKVEDILAKDSESPIDESESESVKSSQDSDIVESSQEPSTNSKLEKLEKCFIKIKKVEVVQVTKTIVDEIQAEKESKERKVIETTPIDLVETTPSIIQATAEPEKPTSVLHESKKIESVPVKPSIPVSHASSPKSTNSRLFRSKAFPLQGRAAQMLGLVTKQSLAEKLSSDASKSDSNCADEGTVVPISKKERVSKENDRVSSPSTGSRQEKMFSNMNNSMRQEMCLSPSITMFCNLRNDGERISPKLDKHERDSENEVMPMEKETQNGSATSNSDSSPNGKTKKELPLLEWSNANPPSLTASPSASILKRMQEVDVETPNRKKRVSFADPPVSREMGYEIMTESSSPPKLEKLPTMRSPISRKESRKHAKLRLIQMDLERTEKENNELANDVETKPTEPTVIDESAYVSTDAPMTCLSPKVMLSAILSDISLDESKIAAAESQVVVNTQDVDIFSDNNVIISNNESLGIVQTSTQNEQSSSSIKLDSINLSNILQKSSDNHNPSLEDTVDVENLSSSLEGTANLSDKAPQKSCSQQSGDSGDTLPVTDSIFSNLPHSQETQNSVVQLIEPEALDSTLPVYPSLVSCIDGVETISADLVDPLFTNDLAKHLSVKSIRSVGDLAQLTERDVNRLPIKSPKLACIKKALSRYESMKKLTRTPEKRSPTPKSSTPLGNKSRESKTKPESISFDDLMKNSSNNSDLASINVSAVYDIKRLRKRQSIDSSMQTSPMKRSKKSDEEACTELMEQCDDDFLFNAFVKRFDAGKILTGYREKMGEHSDKELKKKTLDMLGLSVEDDSEVSFKTSTKSMGLQKVLQQLPKIFDTDESFYNSVLKTYKKKLKEVIVDKFSSSEMLTILAKKLSQEKEKGEIERIPNSNDLKIVLDNVSPDSIMDQVLARNELVSSEILLNIALENSPEKLSENIKKAMYKTLTDKLDVCELADMYHETIKSGVRKMQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9N3</accession>
    <name>A0A232F9N3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000580">
        <property type="protein sequence ID" value="OXU27574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9N3"/>
    <dbReference type="OrthoDB" id="7675507at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="295" mass="33910" checksum="B3A18B82C2257155" modified="2017-10-25" version="1">MQHDQSKITAMKKAERIRNGRTPDRTDVRNLNMSMMSNNNILFLAAMSPKRKVHTSRMSMMPPPSLNTTNASRLSTMPPPASLNTTSSADLRKMQLENNNLELELMYSQYIASYAELILEKKKLKEAEESFSKTMLSLREETRVLLEKYQALKTRLKDIQAYSDLNDYMDIIQENMKEFINKLEKHGIKDKLSHLEKALSRFNVLQCENIILPSNAEEMKEFQKTLEDCSTTLQQISDPMQADGIENVAGNYEEFMRMYTEFSGVKKIVEEKICNLQADILKTCSHLLSQCNEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9N4</accession>
    <name>A0A232F9N4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000651">
        <property type="protein sequence ID" value="OXU27180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9N4"/>
    <dbReference type="STRING" id="543379.A0A232F9N4"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="211"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="369" mass="41220" checksum="E0D58410004469C8" modified="2017-10-25" version="1">MSTIVLPNGLSTFLISAGAVTLLSFGLVWGEKNRKRAARLVAERKLRDEILASPDSSWKKVGSVKEIYYYPLKSGKGKPVEECNFENVGISVSNEEFIPMRDRMLLVYEEKTGKFITGRQHSKLLLVSISAAGEGRVKLEAADMPPLILNIPMLSDPNAKVIKCTLWFGEPVKCLDCGPEASAWISKYLKGSGSDFQLGAWFPKCERFISKGASWEPYAKIYKTIRDEDMGLYSDLSSYMVLSESSVKDLNERLKNPISPLQLRPNIVVEGSDPYAEDEWEWIKVGKDAIIRNVKLCTRCSMVRVDPDTGIPDPSEPLKTLRTYRKLKNPELDALENHAPAIGIYCGLYASGVVKIGDEISVYRPDKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA48</accession>
    <name>A0A232FA48_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000621">
        <property type="protein sequence ID" value="OXU27350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA48"/>
    <dbReference type="STRING" id="543379.A0A232FA48"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28774" checksum="B60C4894FCA34A3A" modified="2017-10-25" version="1">MHRKSLLQAEMAYNLEYVAARIVDAIAAPGQGLLLFRVLSFAVQLAEATFGRLLDQVFESELEPYAFAYLEDIVIAKPSQIPQQGIPSPKKGNLRMNFDKCKFCVEFLTYLSHVINKDGIYTDSEKIRAITDLTVLTNRRALCRFLGVITWYRSVMESSSAGSVTPQSTIFYKCHPKMKVKIVICIVCEEAYHVSDFAKLNGAVKISGVLGLCPEHNLGDITSKVDPNLLTNGAKTIIAQIKLAYTETTLNPQSLSTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAD3</accession>
    <name>A0A232FAD3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_008541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000634">
        <property type="protein sequence ID" value="OXU27287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAD3"/>
    <dbReference type="STRING" id="543379.A0A232FAD3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="521" mass="60328" checksum="F21BE95829BEA682" modified="2017-10-25" version="1">MSSLGYTWNYDTKLMMACYAIPLSKFIPKDFETSNKTDLANVFYIDLNSGAGLYICSSSNQHRKINLFSDESHEDLKKPCKVDFCGKTLQIALYYKPPMTEYIMKTGNISDVAIMERITDIKIVSGFEVQFLKSLAKHFNFKIMLMNLGKGESISQQFKKGTVDLLANFLIIDHGYHIGYTASTYPLLHHETYCLVLHRSYLPQRIINLFEIFEYPVYLLLVAVSIVVSVMWLLILKLLAKLSVGNLPISSIVMDVISIVFRESISRKMHFYQERILIATFLLYILVIMSIFDGNLINMYNKLDTNPPFKNLQQFLTSNKSVLPSNTEVEMGLDKEAWEFANFDRKTVILENFTNIRGQFLIVQNYKKFLRQGYAILSFLAEARQKFVENSKDGDATDFVILTDILKDLRKKKGIIVSKRLRFLSRINRYITRLREGRITYLWCQSWNSEFRNRIKMSNKSKGFHDLALSEMQVPFICLGFGVLCSCIVLLLEIFGSKCRKFITIKSKMLYTLVKLKNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAE3</accession>
    <name>A0A232FAE3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EndoU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_002489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ENDOU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000601">
        <property type="protein sequence ID" value="OXU27450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAE3"/>
    <dbReference type="OrthoDB" id="430326at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21159">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039787">
        <property type="entry name" value="ENDOU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037227">
        <property type="entry name" value="EndoU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018998">
        <property type="entry name" value="EndoU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439:SF42">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12439">
        <property type="entry name" value="PLACENTAL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09412">
        <property type="entry name" value="XendoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142877">
        <property type="entry name" value="EndoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51959">
        <property type="entry name" value="ENDOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="EndoU" evidence="13">
        <location>
            <begin position="342"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU27450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="605" mass="64082" checksum="83DE610FEF5520F1" modified="2017-10-25" version="1">MIATINAEFRSGGVEVPWEKPRVIAVMRGRLRAWVGDIDARKSSRRGGSSGSSGWGLSKSRSTPRSKPQQQQQSHGSSGGSNPGTIGWNVPGSKPVGSGTAAGSSTYPKASAPSEHVSKTSATNVQSGYPGSSTGGHGNPPPYSPSGGYNHGAPPAYNPSSSGGYHGGPPSYSGGYHGGAPPAYSSGGYNGGANHGFNPSYGSYGTGHGFNSQPGQGYNPSYGHSSYGSQPQTVIVQGQSSRPGIGQLAKEAFVFAGVSAGVNAAVNRILPGGIYGHSPSYGASSSGVVPPVSHTQITYNNYYNNGTGEAQPGAPAGAAAVAAPQQQQQQQNAASPTGFITSDAELQKLTEDLFTKDTNNAFKHITVKVQGQKMDDSVTDDAAENLLEVKPEAWEIPTVKAVVALLDNYELDVKTKETVTSEERKEESDLLDAFIATDVMKTTMKFLADKGYVPNDEYEFKDSLKRIWFSQFKRIDGDPSSSGFETVFLAEKFDNEIIGLHDWIYFAKQEEAKKIDYLGYIKKLDLGTNGAIVKGRSKLNDVVQPITTIFVGTSPELEMALYTLCFYTRPNTVCPIKTGGADFLIVANAVNYFGKDILISAFPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAL7</accession>
    <name>A0A232FAL7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000519">
        <property type="protein sequence ID" value="OXU27886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAL7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="16781" checksum="9B2D1FB4201ED97C" modified="2017-10-25" version="1">MFKIQDIFWRTLSSEETNSQTRKMRVLCLSAIVCFLAYLECARATPYADPFAEPDPGLGNKVGEFCNSTMTTATSHKDFCKHVSKKVVDKVHGICQKAVNVVCKFFKEKSKKRKKCLKWLGENVCPTFSGNTTTESVSTETKAPLAELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB53</accession>
    <name>A0A232FB53_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000483">
        <property type="protein sequence ID" value="OXU28066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB53"/>
    <dbReference type="OrthoDB" id="8186944at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="291" mass="32441" checksum="C813384341A5EB1B" modified="2017-10-25" version="1">MVYLFGVSIALWQLGEMSDRRSYTVTVSETRTMDPARAEAVLGVLYVASAATSLISAASLVVAWQHWAWTLDVCINFDCGCILYGVNTFSTFMGGDVKLCHYGSFGLIPAIIAGIGLGFYHGYRSCIPRSLSEPRALGVARHRHSRTSLDGQVVVIGPRQRAPCKQWMPAAFIAVLICCLSLAHAVVLTDGYYKTCEQYRRNLVRLLNSTGQELQAIHNRLSCGAILDFMDYIQPDANNWRRSDAINTGLALQLAIVMSWLNFFSWVTIFLVNINMARQRFKSLNEKMCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBB6</accession>
    <name>A0A232FBB6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000542">
        <property type="protein sequence ID" value="OXU27780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBB6"/>
    <dbReference type="STRING" id="543379.A0A232FBB6"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="153"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="367" mass="40787" checksum="007907004766924C" modified="2017-10-25" version="1">MATDQKKSKMEDSLAKKKPRPILAEELIRLPELQKSFIGILKEKKGISKAIAVLGPILPSPQHLKRCSGLRIYLAPVDKMNESAEGLKKLLSDKGFDLTLFEDELEISDVVATPPRTKSQMEYASKFWPVNFHPDLNLEALISGSLFNDEQLASLEFCMRLAIAAAKDSAIGSSECNGSAVIVNPDDATILSIAASSQDKHPMWHASMLAVDLVAKVQGGGAWKLIRDSNSETDTLKRKHIDSLPLRYPESIFKIEVPKEDGLSFIAKNQKKKQESRKEFDDKCGPYLCTGYWAFLLQEPCSLCAMALLHSRVSRIFYGAANPKTGILGSRATLHSVPGLNHRYQVWSELLRNECEETLKACRTIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC66</accession>
    <name>A0A232FC66_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000510">
        <property type="protein sequence ID" value="OXU27927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC66"/>
    <dbReference type="STRING" id="543379.A0A232FC66"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="536" mass="58064" checksum="5ABEF1D54643B204" modified="2017-10-25" version="1">MRRQGQDVMQVNLAGIRRDIVNLAHNYSNAQKAVRKATSNDPWGPSSTLMAEIADLTYNVVAFTEIMQMLWKRLNDHGKNWRHVYKALVLLEYLIKTGTEKVAQQCKENIFAIQTLKDFQYMEGHKDQGINVREKAKQLVALLRDDERLRNERARALKAKERFAQSLSGFGSDGVDTASPVSSDFQEWEPCHLSESSSRPELEAARPQTVGEEELQLQLALAMSREEAEQEEQRRRSDDVRLQLALSQSQQDFKTPQEKQSHMLDLLDVNLGEPSGANAQTDPWGVPIAAPPPPRPQPQNDPWSVPTTNSATAASVDPWAPVLPQRPTATVDPWRAPAPSPATVTPAPARVVDPWAPVTATSADAKSPPPIGFNVSSSNGFNGLGSTFNSTSASNQGSNSPLGDLDEFDIISNRNKIGSSPLPMNNGNTTSPDPFDLRGLSDTMPASTGAVKKTPQSFLGENSALVNLDNLVSASSIKAPAPAPAAPVPFAANPFAPVTPPPRPSINQIRQDPWSSTSVAANSTPTPTAAANPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE38</accession>
    <name>A0A232FE38_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="4">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_007135</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000392">
        <property type="protein sequence ID" value="OXU28699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE38"/>
    <dbReference type="STRING" id="543379.A0A232FE38"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="15">
        <location>
            <begin position="132"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="14">
        <location>
            <begin position="364"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="726" mass="80929" checksum="8B5D3D8796F60E67" modified="2017-10-25" version="1">MSTIRWIETGLHRSSTNWSSLRGGYLWSPAKRTYGGLARAGIARTGVARLDHHQQIIAKREFAIFNWRSAVLRNGEKMSITVATRYPQVSNKLMVTHAAKSPSSKYETQDRIADTPVINNIGTPLAPKVRTFIEEAVRLCRPDMVYICDGSEAENEQMLKLLESKGTIEKLPKYENCWLARTNPADVARVESKTFISTPNKKDTIPTPRDGVKGLLGNWIAPNDMDQAIMERFPNCMKGRTMYVIPFSMGPVGSPLSKIGIEITDSAYVVCSMRIMTRMGEKVLQALDKRDFVKCLHSVGVPKAGSAGKIDETWPCDPERTIILHKPAKNEIVSYGSGYGGNSLLGKKCFALRIGSTIARDEGWLAEHMLILGVTNPKGKKRYIAAAFPSACGKTNLAMLQPTLPGYKIECVGDDIAWMRFDAQGKLRAINPENGFFGVAPGTSNSTNPNAMATIYKNTVFTNVAKTSDGGIFWEGLEKEVPENVQITDWHGNPWQRGSKTPAAHPNSRFCTPASQCPIIDPAWEDPEGVPIDAILFGGRRPAGVPLIYQARNWQHGVFIGATMRSEATAAAEHKGKVIMNDPFAMRPFFGYNFGHYLDHWLSMSRVENAKLPSIFHVNWFRKGPNGFLWPGFGENSRVLDWILRRIDGEDIAVDSPIGYLPKPESLNLEGLADKVDLQELFSLPKEFWKKEVSELREYLDKQVNDDLPKAILEELDNLEKNVDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF18</accession>
    <name>A0A232FF18_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid-binding serum glycoprotein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000346">
        <property type="protein sequence ID" value="OXU29029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF18"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012443867" description="Lipid-binding serum glycoprotein N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="45410" checksum="BFD490534687D0AE" modified="2017-10-25" version="1">MAFLYLVIGVLLQRILPIFASNQLACNLFDYYASHDGQVNRDRTFQGVARVDYQRSDLAIYTYEFTNFVNFLIYDFKIEFEGISVKPNGSSNKLSLSLKTDLEGVGFLSNTTRTHLTKCEIDLERNIKYRKDIPLNLQKLLVQLVSSCIRPKLCEQLGKPKQDDFLQAEIAPHDFDDNSAMCEALSAKYPNLHSEKKNKNDTIQGTINAFADFWIASALSQLPGNIPGYIDLPSLNETMDGIPLINKGYFRLYNGTFGNLRNIKRSEDIVLTNKGIHFSAVGGFYLPQARFHFDQIALKYGVISTDGKLDIDIDGIELNVRIDMNYNTNPCKVNVVRLNSTFGEVSFKLSESNVLESIVNDAISGLINKFTRNLVNFIELKLRELINVPLHNFDCEHYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFA5</accession>
    <name>A0A232FFA5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Acetylcholinesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_016097</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000297">
        <property type="protein sequence ID" value="OXU29375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FFA5"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167145" description="Acetylcholinesterase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="3518"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="14">
        <location>
            <begin position="1846"/>
            <end position="2535"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="13">
        <location>
            <begin position="3028"/>
            <end position="3473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="2414"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3137"/>
            <end position="3165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3193"/>
            <end position="3307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3146"/>
            <end position="3157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3193"/>
            <end position="3218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3226"/>
            <end position="3240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3248"/>
            <end position="3260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3274"/>
            <end position="3292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="1939"/>
            <end position="1946"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU29375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3518" mass="399068" checksum="B71F0D064D1D1CD6" modified="2017-10-25" version="1">MSAITLVVLLLALTVNGESALTSVVRTNKGPVRGEILTTVQNELEFAAFKGIPYAKPPVGHLRFKPPVEKEAWEDVLSATTEGSMCIQYNSTDSTVVGSEDCLYINVFTPHTQFDESLSKPVMVWIHGGAYRTGNSNASYYGPDFLLEEDVVVVSFNYRLGPLGFLNLNHENASGNYALKDQNLALKWVKANIANFGGNPDKITIFGQSAGSVAVDLHVLSDMSAGLFSQSISMSGAPLCLYWGFQTSLEAEKTAFLLGSKLGTNTLSKDTLLKTLVEASAVDIINKTNDIPLIPFRPTIESTAIAKKQEKFLTECSLKKYSSGNYNKGPHMMGFTSSETVAFAGSASNLLDMATAVLTSIKTATLNINLPFISEVAAMSTDAIANLTESALYQLIEETSDLLFVTGIDSKQQLLRLHNKYPIYYYRFSFNSNYSAHRTDGVDLDGVGHEDELPYVFYRPQVELPLDQPEIELTRRRMVRLWTNFAKYGNPTPDGRRDSELGVTWPDSGLLGRHLEINKDLAVGLRPTDVSVKAYEVAGLGASPILNDCSINIISGAIDGITNIFEVPYSRDVCASHPNVVHMHLNWTYSLIIQCETVYSGIRTTGALTIECKLTDIVHTETGPVQGEILQTVLNSVEYSSFKGIPYAEPPVGHLRFKPPIKKTHWSDVLRTTLEGANCVQRDFVYHNYTGSEDCLYLNVYTPQTQFNSAVPVSKPVMVWIYGGTFKSGYGNSSLYGPDFLIEEDVVLVTFNYRLGPLGFLSLNHDSATGNAGLKDQNLVLRWVNENIAKFGGDPKKITLFGQSAGGVAVDLHALSDMSKGLFHQSISMSASPLCPWSFSTPDASEKQAFALGSLLNVKTNSKEELLEALYKTPAVLLMQKTEELGSMNPPFAPTIERSDIAMDQTKFLTKCSYDKYMDGDFSDIPHITGFTKHETLLFTKSLETIMDLLNTTANYVKSIPSLSPISIPFIDTIISIVEKGTTFISESVIMQIVEETSDLLFVQGIDSKQKLLHRKSKSPLYYYHLKYETERCIHKQLYNISLNGVAHGDDFGYLFHIKVANLSLDANDLAFITRKRMVRLWANFAKYGVLKRILICTKSNPTPNGTDDDLLEGMTWPVSGSTGTHLEIGKHLIVGQRPTKLRVELYQLANGLTLPLQTGCTANTLTAIANFKFIICFSIGIIGLIINTESKSTPVILTTKGPVQGEVLNTAINSVPYSSFKGIPYAEPPLGYLRFKPPIDKKPWSNILPTVIEGANCPQKDFVYTTEYTGSEDCLYLNVYTPKLNDTASDLLPVMVWIYGGSFKSGYGNSSLYGPDYIIEENVVLVTFNYRLGPLGFLNLNHDNATGNAALKDQNLVLRWVNANIEKFGGNPKDVTLFGQSAGGVAVDLHVLSSLSQGLFHRAISMSASPLCPWAFQTPEASVSQAFDLGRRLGKTTKSADELLKTLYNTSAIEMMKITNDMGLVNPPFQPTIESTTVAQDQEKFLTECPYAKYLSDQFSKISYITGFTSNETLLFAETAEKFLDAVTFATNVVKSAPSKIPIPLPGSKKILGVLTKEVKSLSNFAVDEVIKETSDVIFVAGIDYKRKLLQERSGHPVYLYRFAYQSDDSLHKQLYNIDINGAAHGDDFAYLFHMTVVNQSTDPQDPSFITRKRMVRLWTNFAKYGNPTPEGGNDTLLQGLTWPITKKHNSYLEIEKNLSIQQDFPKHATTSLVEAADVVILPLQTGCIGNFAKKIINVKPFTDEVKSIGSTIKNTSQAIFSKIPIIELIFITKMSTESLYKKGFKVWIPHVNKVWEWAVILEDYNTDTKTLRIETGLDRETTILIINSNSDLPHLCDTEDFFIDEKKNLASLRSVHEASVLNNLRLRFEKGCVYNYCGFTTVFINPFLKPIPREADNIFKYRGQTIDDLRPHIFAVAEKIYCRLERENRDQSIIFTGKSGAGKTENAKLAILYLATISAEVDQMKDKITASSTILEAFGNAKTIDNDNSSRFGKFMEMQYDANYHIVGASIRIFLLDGSRVVNQIQNEQNYNIFYELCSVHDRFPDLHLNRQEFCYLNTNNSSEMYSNYSKRFDDSVEAFKKFGFTVQERDEILKILAAILHLGNLNFKKFENLEGSENLKGCFIAESHQLEILEKLLSLNPQSAQDMKKWMCHKKIFSNGKTDTCPMSMEEAVKARDSLAKFIYRKLFIWIVSRINYLFFSSSNFRCSVGILDVYGFEKFDVNLFEQFCINYVNEKIQQTFIQMVFKLEQEEYLRDNIGWSFIKYQDNRLCLELLEGENGIIHVIDQESNNEVPRERPWINAMFESTPCKESNHFERPKCNDSTDFIIHHFVDYVQYDSREFLEKNEDKVSQEHIAFLRDSNNEVLLMLLSDDLYRKNIPNQKKRPRSESREPLSEYPTKTTLISELKESLIDLTKELQNTTAHYVRCIKSNDERKSYEFDPVCVAHQIRKYNVLDAIQLSSMGYFSRQTYANFFNRYYCLCEFEGIQRDDLQETCRVIIYNLIEDSKSVKFGVKYIFLKEEIINHLENLRREKLNSACIIIQKAVRRILQQKRNQETRRAVLSLQSQVRNYLIRRRQARGAAEDHALVKNEARTMDEIRASAATEIQRLFRGFQARRFSKKRVRDIITIQTCIRRFLAQVAADKLRENRIGQVHSLNEGLKAKIGEFQRDINAYMDMNLTKEQLDQVQMIAGDQQCFQAKNRLINEIIIRRIQNIRDEGRKVKPVELPVISEHQDLEDVGAGHADIPVMDELQDLGEIRARSADRPAIDNEVKITRSFCFYFKIPVEFLLTHDTELSRILGSRFEMKTANLSIIDDLELEEEVEKAVDHPVLNKLQDIGAEEENSINFAVMNELDFGEEEEYSINFSVMNQLDLGEEEVKAFNPPVMNEAQYENSRKVDENSLSEVFKSLLATEEDFSLYQPLFQACFNFDQRMEKLMDACGINRREVEQARPAGRNDGQGFVLSEGMFQFEIADIESLLTHLIGLPTLTITNEKPGLPSRILFMCLRYLDRQNDFISASLMLKKYVETVESLIRQRGDLETLLVWLVNTYQLHNYLKQYARVTSHNNDIDQFQSLNTNQQTEHCLVNLNLESFCESLLHLAEALAHKAAQLMKTTIFDLAELGILEYNPASVSHSEYSDSDGERSDDSRTETNEQDEEELEDAIEIADLSDGKVQQLIYQSIQELAQNQPAPIQEQEQAQEQEQNLPQEQEQALGHKQELAQEQNQVQEQVQEPAQEQHQEPPQEQEQAPGHQQELYQEQERRSVQGHNQDPPQEQEPGQEQNQDPSQEQEPEQEQEPIQGQEQAQLLEEEYDQDFLRMKRNALLQRLTDFHLAMETSGLDANMRQQMFKKLFDFMSTILLSYILSHPQLCNVYRGAVSRVNLRAIERWARYHKLNVATIALGPIKQALRLLQMQPMEDYDVFWIDKLYDKLNSDQILRILSCYKPAYAADQPISPTLMQKLKLKLERWDGRDETVLINSEEYPVIFPFRHCSLPLEEVEIPATFDLPMLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFC4</accession>
    <name>A0A232FFC4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000295">
        <property type="protein sequence ID" value="OXU29395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFC4"/>
    <dbReference type="STRING" id="543379.A0A232FFC4"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000026">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000029">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="148"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU29395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="295" mass="33630" checksum="581BB186951C6DB5" modified="2017-10-25" version="1">MAYTADLVAQQIQERLKQIHGLVFLIEESRGHSEYNIGQIEKVQDEVTCEEKLNSIEQRKLKLVYGRAVDDAKEQEKLLRTTLDKIHEIRLIRNKRRVQARKAGNKEAIRRGTLMKMLLVTAQTLPLYVGKTPGAKPPSLCGCIPAENSYVAKMGDMVAAFVKNLEGEENWILAEVMSFNHSNNKYEVDDVDEEEQVRHIVSRRRVVPLPLMRVNPETDAHVLFPKGAIVMALYPQTTCFYKAIVNSLPTNAQEEYEVLFEDESYADGYSAPLNVPQRYVISIKEGRKRIKVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFM4</accession>
    <name>A0A232FFM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_005259</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit AP50) and a small adaptin (sigma-type subunit AP17).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000274">
        <property type="protein sequence ID" value="OXU29566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFM4"/>
    <dbReference type="STRING" id="543379.A0A232FFM4"/>
    <dbReference type="OrthoDB" id="413467at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1230:FF:000003">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000004">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 11" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="706"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU29566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="939" mass="105224" checksum="B650D5F18EEC39CD" modified="2017-10-25" version="1">MPAVRGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYSEKQIGYLFISVLVNTNSDLIKLIIQSIKNDLGSRNPIHVNLALQCIANIGSKDMAEAFGKEIPKLLVSGDTMDVVKQSAALCLLRLLRTAPDVVTDGEWTSRIVHLLNDQHLGVVTAAASLIDALVKRNPDEYKGCVALAVSRLSRIVTSSYTDLQDYTYYFVPAPWLSVKLLRLLQNYTPPTEEPGVRGRLNECLETILNKTQEPPKSKKVQHSNAKNAVLFEAISLIIHNDSEPNLLVRACNQLGQFLSNRETNLRYLALESMCHLATSEFSHEAVKKHQEVVILSMKMEKDVSVRQQAVDLLYAMCDKSNAEEIVQEMLNYLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDQRSSPSVQFQLLHSKYHLCSPMTRALLLSTYIKFVNLFPEIRSQIQDVFRQDSNLRSADAELQQRASEYLQLSIIASTDVLATVLEEMPAFPERESSILAVLKKKKPGRVPENEIRESKSPAPNTNHHTETTSATVAASAVNNSSADLLGLSTPPSSQPTGNTGVLFDVLGDIYNMPNKGTANGTQATYNAKKFVCKNNGVLFENDLIQIGVKSEFRQNLGRIGLFYGNKTQQVLLNFQPQLSWSDENQVKLAVQVKPVDTVLEAGAQIQQLINAECIDDYNDAPSMIISFMYNNILQKITMKLPLTINKFFEPTEMNGESFFARWKNLGGINQQRSQKIFKAQTPMDLAQVRTKLQGFGMQLLDGIDPNPDNFVCAGIVHMRAQQVGCLLRLEPNKQAQMFRLTVRSSKESMSIEICDLLVDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH05</accession>
    <name>A0A232FH05_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_008302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000216">
        <property type="protein sequence ID" value="OXU29965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH05"/>
    <dbReference type="STRING" id="543379.A0A232FH05"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006670">
        <property type="term" value="P:sphingosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="132"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="425" mass="48416" checksum="03B907B4420E3897" modified="2017-10-25" version="1">MWSNFVQYCKDPHLVARIQEFFGVEIHYDRQNKSKDDCSSRSERNGLNKSSFQSINGCTPQENEGTIKKRHNKVLQSSDNDASTTAKEDKPYTIKNHFWYYLFLFGTQLGDEVFYSTFIPFWFWNIDGAVGRRIVLVWAIIMTIGQALKDIICWPRPQCPPVVRLQSKWSLEYGMPSTHAMVGVSIPFSVVLFTMNRYIYSFPAGCVAAVLWCTLICVSRLYLGMHTVLDVITGLVLAILMMIPLVPLVDAMDYYFLTNSWALSALVVMSIATIIYYPCSDKWTPTRGDTTLVVSVTAGVHIGAWLNFKTGALSMPQVPPPYNIMWPSYPMFGRMVLRTILGFCCVLGTKAICKSLSYTTICAILRVNSKELMQSENSLENKNKILVDLVYKYIFCFMIGFNTVYILPNVFTMIGIERPTFYTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH79</accession>
    <name>A0A232FH79_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000193">
        <property type="protein sequence ID" value="OXU30116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH79"/>
    <dbReference type="STRING" id="543379.A0A232FH79"/>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="115"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU30116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="481" mass="54399" checksum="36351C024F78BD5D" modified="2017-10-25" version="1">MDDELEDKILYQTYLSHMKLMSKFAVGIPTAGINTFLSYFWRIARVYVFKPEVLVFGLIIFIIFLYMQAVDAWSRTLFEKIQHTLGITTSKVAKLQFLVNSSSVEKLGWEFKQDYIAAYAVQGHRAHMEDRFVVNNDINNTGVSLFAIFDGHGGEFAANYARDKLIPSISEQVVKLKDIITGKVPKNAQKSEINENINEKEDENTKTETSAMKRKKSWRKTSSTDDYAKRHNIGITDPELLEKLDSISKTITREVRPSRPNEKENLPRIDVTSYIEGREINYGRLLTDQVLAVDRLLVNAAKKNMDVAGTTALIAILEGNKLIVANVGDSRGVMCDGKGNAIPLSFDHKPQQQRERNRINKAGGVVTFNGVWRVAGILATSRALGDYPLKDKKFVIAEPDILTFDLDDHNPMFLVLASDGLWDTFSNEEAIAFIKERINEPHFGAKSITLQSYYRGSLDNITVLVINLRDRKISELKLNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHU2</accession>
    <name>A0A232FHU2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-dependent protein kinase catalytic subunit CC3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000180">
        <property type="protein sequence ID" value="OXU30252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FHU2"/>
    <dbReference type="OrthoDB" id="431717at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046803">
        <property type="entry name" value="DNAPKcs_CC1-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012582">
        <property type="entry name" value="DNAPKcs_CC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045581">
        <property type="entry name" value="DNAPKcs_CC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20502">
        <property type="entry name" value="DNAPKcs_CC1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08163">
        <property type="entry name" value="DNAPKcs_CC3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19704">
        <property type="entry name" value="DNAPKcs_CC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01344">
        <property type="entry name" value="NUC194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-dependent protein kinase catalytic subunit CC3" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2232"/>
            <end position="2259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2242"/>
            <end position="2259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2510" mass="292620" checksum="D9ED1948B0AA976A" modified="2017-10-25" version="1">MEPVESFMEMLARAWRDDDKQALRRIFGNAPGHLQTVPDKYRETVLRMIFDKNKGIFKFINSVLDIQAPCINQYDEILKQVFHLLQFIMQSFKLEYEAYILLTKVICLRCIKEHFSLAVKIEASKTFKLLIQLFHAYDLKLDEIVELYKEEKVFIIVVGAIAKYCPKTNNLESLADSIYLKLLMELNEQCKLSGRMQQHEYIKNFKNYFSMKLSDEKLSCNELSLVIYGFGYFSAVYAKYSPLELDEVFQKLSYQTISFPAKKNDVQIIQMLPCYLQAVTQISNYMPSFKTSHLDIAIKLSVFIFENFPELDDRNKCNAIKALKITFKNIYKLEQIFQRQYFDRLFYKRIVWSCSHPLFIDVELQQEIQNLSEHPVFCYKDSLQLWHGLLKTHKHDEILVKNIFKEVISVLFNFVENLNLTVKSQQNKFRPDVSLSHKALNEAHFRYFVNLVDLYVDIFKEVEVSLLQVHVERCLRDIIDETISVFEIAFKIGLKNNIPLTFHALETLEKWSSSFKVEYLHKVCKNVIVYIEPYFAMQPNFEDEKDKSVESLKKKILSLYSSLDQKILMNIINEKSIDTDLLWTKKKLLLFKLHFTDIQFEISFDKFMSRVIELTDTENRRKKISACEFLHVLVTLLLGRKVTDCCFKNLFYVVLKLGCDMDDTVWNLYHPLVIQLTHYLSSKQMIESKVSQEFINSLFDGLSQEFNPSLRDYCGICLKEFVRWMIKQSPGNDSSKSTNFSDLFNRIINFALHQSNNKKLAAVIAFNYLYIILEGSISVINTYWLEFLYAFVKCLEKCNDIRVVSALNNVESVIGVTQGILNAKSFDRRRHIEFSSETLRGATMWLFSQCGVLNAHCREKSMQLFENLCVLVTGCKYVKDFISSCGIGCVNAIALKNLDEHFESINVKNTKTFLRSLDFYIWMFKKKYLTPKCVLLVEKDSEEEGIFLRFFTKFVSKFIDNNITDIIKTTTNSYKEAEELNDSLNAVMLKIIEFTSVVLETEEERLEQILKNLWNKNLNILISRFTLCPRKLGLTSKSLQTLPSHILGNWFRLIMKKLPEPYLKELKENFFNEKTEDCKNFVNISEIISLKKDVQSLGDFVYGMMLLKNCNFYNPEKEHELSIDYSKKIILSIFEGLKVVKMNGYANTKAETNITTYLKDLLRFFLLEYKPELIECVVDLITNDPSFASSSDSTTGYYEEFYEPLKVPIFQCMLKNPPLSLRILDSKLRDSPDKLFALIENLLYFAQSYHTNQSDILANEVIKNCDNYRALLGENDRRLDRFFSLNTIAVDLNPMDVMPADGTPSGLYGWILEEFNKAENLGRKAVIIERFLICMTDETSKQNPDLTLVLWNLRPGNTETWLRELRASEIERSRAVQCLRSLLKMLLVTKSWIVFEGLIKYAAGACKLFAKESIAEHVKSYFTSIVADSIYQLLGSIYQIFQDTTIFDVNERLDILEYFLLPSLEACRVSVVGKFYEHTRVELTNILTNGLNELDQTERNQSLVSRIGSFRIFELMFGRLTSPAKGSVDLLLLDKSLEVRSFSSTATDDKEIVRLLHCAALNCCIAVVGSKGDDEKHAVVFREIPENNILFWDRIVDCERKYNFQPGLQRLTKRIINIRRTPEDLQIPIEPTFDFYFSRYDPTDIDFNKSNNPTDRRQSLSLEEDEFNEHECTAMITGAIIHLSKSMTRLPDVGDEVAETDLPLWLLCFRGAFNTSQDNVRLLLMRIVSNARNVFVPYLRSMFEELAKTVTHYLKENPLNYLVRNILFIFIECKYDLKSQQEVSIAQKLFEAVIDKSMDEDDKVCLYNVHMLEGLVNMWEERLQTPNNLETIIAREGELSIKIVLMLFRHRIDIDNLIKKREVHKLVRKLMFKWQEPTAPHAFETLGWIMRSITDEQRDVLIKDDLLDLFVDMQRLSKDICVRNFYLTFIGCPVLSIREELRQFRDPVPLENDERRAECFEIFLESMTNLTSEEIFSMLNSMNLAGLLHDRVFPCVDVGFRILYRLTFILEDPQLLPYAQVVEVYTKRETLLEHKKMAYAFFMHIYEKRTNQDNRMDVEGESGPNALLLLSRKVLINGTIDPSDEIQDLLLTFWKERLADITSTSQRLYHLFKLYTPEIHVSFAQFFCVMMLDLTTHSPVDNRILFAPLAECWFEDHEVATSRRWERRRKRNIRSAPLFAPSLTGMLECAVVEQGSRMRRLDRDERLQETPAGALAMSLDVIDRLTRPNGPIRIERAPDPSRIQTSHQNRQTSTSSHTLVDNYYERIKQESIEQRESAKINRRYRIGSYPDIEITQSDVVVTLDDLVRQDAKLANDLLVSIICAMAENIEDEAFHREYMNEVAEFCRSVLKEPNDFAPTAMRLVLQTKCTDFDVQDVTRLAKAMGHQILGILLLEMVSIERNKSKYTYQTQSMFASAIVQPLHHNLELSNLYRSIGEYDVVECISRNWILPAGLEHLREGCIEEAEGDWIAAKTRYEMAWEILDEPCRDHCVDGLLRVRTNYDTYLFKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FID7</accession>
    <name>A0A232FID7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Golgin subfamily A member 7/ERF4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_017056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000198">
        <property type="protein sequence ID" value="OXU30067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FID7"/>
    <dbReference type="OrthoDB" id="67682at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039735">
        <property type="entry name" value="CHIC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005:SF4">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="3">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="19017" checksum="C64F98C2224B29B9" modified="2017-10-25" version="1">MADFDAIYEEEEEPEQNPEEQYVTIVPDPIVVRGAGNMTVFGLSNRFESDFPNGLVSRVAPEEFKATVLRINSVLKKTLPVNVKWLFCGCVCCCCTLGCSLWPVICLSKRTQHSLNKLLEWENSRLYHKLGLHWRLTKQRCDSSSMMEYVLLIEFIPKIPIYRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIG2</accession>
    <name>A0A232FIG2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_013545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000155">
        <property type="protein sequence ID" value="OXU30475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIG2"/>
    <dbReference type="STRING" id="543379.A0A232FIG2"/>
    <dbReference type="OrthoDB" id="1867783at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU30475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="205" mass="23174" checksum="2E4F51B79A2B692C" modified="2017-10-25" version="1">MSEPAQGAQRRATSDFSIERILSKDVPSSSSSSSSASTATVGPAQSTYPSFALQNRLEWLRSFCKLRTPGEPRPSGDAATAGVLAIDNQPSKQPNKSDSTQLNSEELSWLRCTRYRPPKLPRKSSAGKIFKRKPGSHPRIPFTKYQIEILENRYRSSSYLSRDDVVNLSDLLHLPQSRIKIWFQNRRARERRESQTTEQMETTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIW8</accession>
    <name>A0A232FIW8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_003639</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000140">
        <property type="protein sequence ID" value="OXU30625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FIW8"/>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06704">
        <property type="entry name" value="PDZ1_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06703">
        <property type="entry name" value="PDZ2_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06702">
        <property type="entry name" value="PDZ3_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06701">
        <property type="entry name" value="PDZ4_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000118">
        <property type="entry name" value="Leucine rich repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000064">
        <property type="entry name" value="protein lap4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000041">
        <property type="entry name" value="protein scribble homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000074">
        <property type="entry name" value="protein scribble homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="685"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="848"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="1195"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="1286"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="376"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="990"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1115"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1389"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1483"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1673"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1741"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1862"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="992"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1067"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1117"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1392"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1578"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1755"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1776"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1871"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1934"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1949"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1993"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="2004"/>
            <end position="2017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU30625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2017" mass="219365" checksum="43FAD282E90CFADF" modified="2017-10-25" version="1">MYIQSRRVEWLMLSLLRFQIQNSVDGINIPEIPENIKNLRSLQVADFSSNPIPRLPSGFVELRNLTVLGLNDMSLQQLPPNFGGLEALQSLELRENLLKTLPDSLSQLKKLERLDLGDNIIEELPPHIGKLPSLQELWLDSNQLQHLPPEIGQLKSLVCLDVSENRLEDLPEEISGLESLTDLHLSQNVIEKLPEGLGDLINLTILKVDQNRLSVLTPNVGNCVNLQELILTENFLLELPVSIGNLVNLNNLNVDRNSLQSLPTEIGNLKKLGVLSLRDNKLQYLPTEVGQCTDLHVLDVSGNRLQYLPYSLINLNLKAVWLSENQAQPMLTFQTDVDEVTGQEVLTCFLLPQLEYHNDESSRLGMMVGTSGLRNNVAAMTGPGGEMREVGGGSSDEENWSEREQSRTHSVKFSDEPPEGDKETPFVRQNTPHPKELKAKAHKLFSKGKNDSRSTSAEEQDVSQAFGLDKLEQTQQQEMSMTMQQEPPPPPLDQSSRSFIQHEAEASSKPASEAANGSSGAPAAATVAITKPEAIGDAEMDESVTGARFRCNDDDDDKHDDIDGVESEGEETQRHVDFAITEDADYEGGGESGKPNRLHRRDTPHHLKNKRIHGSIDKDKVASIIAQALMKKTDESTTTTTTPAQTTVAATYPPYAESIENVDGHSQGALSDTEPSIEIREEQYEIHIERTTGGLGLSIAGGIGSTPFKGDDEGIFISRVTEGGPADLAGLRVGDKVLSVNGISVVNVDHYDAVEVLKACGRILILVILREVTRIVPPSEQMSIRKDSVCSSMSTSRAPSATSYVSSTTLSHNLENGDADETIKRKIPEPLSAVKQQAADPLVPVLVHTTLIRDQNGLGFSIAGGKGSPPYKPNSDAIFISRITDGGVAQRDGKLCIGDKVVSINGVEMTDARHEQAVTLLTGLERFVRLVVEREIPLSQANPANLTPSEKSPLVIGTPKPYTGLYSANSYMANRPGYSAFRRSIDADKILSPSPTSKTPPSSKTAEVSTTPPVNGIARMNGQVSDELKKSATTNPTPPPQPAPRQSINQQQQPAARPTSQPPAPPSATTSPTPTATPTPGAGEEKAMADTQEDIQVPKPITNEEFQAMIPAHFLRPSTNSSPSPDSSQKGSTVTVTIKQPDGLPGDVSFPPAPTTIGKVTETITKSTLTETVVTRVTDNQLVRPVIIEDVILIKEGSLGFSIIGGTDHSCTPFGAKEPGIFISHVVPGGIAAKSGKLRMGDRILKVNGTDITKATHQEAVMELLRPGDQIILTVQHDPLPENYQELVIIKEPGEKLGMHIKGGLKGQRGNPLDNMDEGVFISKINSGGAAKRDGRLKVGMRLLEVNGTSILGATHQEAVNILRSSGNIITLVVCKGYDKNEIEQNLSISGRESKESKTSSKESKDTITVDDAKSLSQSVSSLDRDDEEAATLRQEQEMKAELVAWEKEERERALLEHREKAEKTVPDKLLDFVKAADALVSKPNSPVDCISPIPPKSPGGTKDLKTTTIVMSKHTLAPQSPPPTPVSLTPGPRDESYGTSVDSPTPPYQQQQQQPKPRKSALTLPSPKKKRGISFASLPSPYRSKSSSSGDLSQSGRPGTGYRVSPTPEHCTLSSGSPRFKLPPTPLTSPDMTIVGEVHGPGEGCPDNAAADTAYLTRRQIARSVVPETYRGFGTTRFEPPSTPSPTPAPAKLSVSDRKRLFENAMEEHLKPSPKPDKVFSFLSQDEVEKLKQEEEKKIATLTRDELKSWAQMDENEGLDDEEPIEEQDNRRPNSRLSSRTGISTLQNVPSIVRTAKAERRLKERMIQEGLLSDEDDESHLTPAEQRALRAEKRAAWRQARLKSLEQDALQAQLVIKKMSEMMDTSAKSESAKDNVDHTEPAPEGEKVTEVETLREKIISLELSNPEEELESVMGTGASDAESESEEPSSSAVDTPSTEQSESTFADSISSAQAISQQTISPSATMTTTTTEDNNGVENKNDDEEDASTEQNNSSSTTSNNNNKKKKRKRSKKGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJB0</accession>
    <name>A0A232FJB0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000123">
        <property type="protein sequence ID" value="OXU30765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJB0"/>
    <dbReference type="STRING" id="543379.A0A232FJB0"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="339"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="501" mass="56220" checksum="B5018550A8C1D50D" modified="2017-10-25" version="1" fragment="single">YTYAVYLLLTVVYGAGNEGRHVEELGKCTTATGRILTDSYALGDAAHYAITPQVALLTTGGTKSYIHQAPLSRRLFHRLLDTRYSSITLYCLPVVSGVSTGVHEKYEQIKQVSSCTGARLIHDRLVRVIGLVVVVQRLDLESILYILGTTMADADANKELDSARKKSGRTSFHSEQFTYTWIIEEYSKCQSEQYSLEIVSPKIVVNQSNHIYEFKLSICPLRSDPIRGSSNTCIDLKVLTCPSDQTDVRVKLCFIRNDGTECNPISAIVAIKKNAVFQNYCVAPSTVYSKCLSNGNITIRCTFTFCRSVSRDKPEYSQLDAAKSIHDEFAELLYSGKFSDLTLDLGEKKFKVHKSILAARSPVFSGMFEHEMLENKENVVRITDVEPDIMSEILLFIYANKVNRIKELTAGIFAAADKYQLEALRLMCEDVFLETLSLDNLTEILQIVDQYETCPRLHDGVLQFLSINGSEVANWKNFDNVMQTLSPALLFEITKATMLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJX1</accession>
    <name>A0A232FJX1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_006541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000095">
        <property type="protein sequence ID" value="OXU31031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJX1"/>
    <dbReference type="STRING" id="543379.A0A232FJX1"/>
    <dbReference type="OrthoDB" id="432835at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF478">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU31031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="260" mass="30162" checksum="05257C2CB507C467" modified="2017-10-25" version="1">MGRTGYTCIRHVFCSLNVLIWLCACGMLGAGLWMRFSYPYAYGTLVPQHSYASSDVLVLATGCFTFVVAFFGCCGAWFQSRFLLITYFSLVILIFMAEFMLGTLAFVFKDQVGDNMKSQLRYGISEHYTEENMHESGTFSNFWDYIQSTFQCCGVDKYYDWYNIKAWPREERVPDSCCVHRERYCGKQYDNDDRQLNWYQDGCLSAIQIWLIQRLHFVGTVGLVIGFLQLFGLIASMILFCTVRHKRSTHTYKSYDTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKP1</accession>
    <name>A0A232FKP1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EML-like second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000109">
        <property type="protein sequence ID" value="OXU30897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKP1"/>
    <dbReference type="STRING" id="543379.A0A232FKP1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF50">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EML-like second beta-propeller" evidence="5">
        <location>
            <begin position="97"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="206" mass="22739" checksum="4E2117F0A9327783" modified="2017-10-25" version="1" fragment="single">MNIKNSKRILLEFSKISFFSLGYLLLVLKLKLKCCFPGGPKQYEGLTEKAVAQICAWMPQPTLHSTVSLPCTTVGLPLIVFLLKVNTLGSLGNAGVCRQIAQGSFLKDAEWATHSCIISFETIGIWHDGFDKIEINSCSRSEDGRLLAVGDSLGKVKLFSYPACQPKSLFHNYNGHFNNVTNIAFLHDDTRLISNGGTDTSILQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKS8</accession>
    <name>A0A232FKS8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000072">
        <property type="protein sequence ID" value="OXU31272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKS8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="14771" checksum="5F5975B89CB4A61C" modified="2017-10-25" version="1">MHDETAIRRSLIVANVNNATKDTLRKTATDEFLFGSKLSENLKAAKLIEQSAGELKVPKSSSTKSTKNFKPPLSTHNKQGQTGGVERGEIFNNSTCKPQTGITEVRSPEIAQQWLQVFLQEELLPEETLSLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLK4</accession>
    <name>A0A232FLK4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_014761</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01000075">
        <property type="protein sequence ID" value="OXU31227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLK4"/>
    <dbReference type="STRING" id="543379.A0A232FLK4"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="58"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU31227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="670" mass="77227" checksum="7CD1FBE8AC101296" modified="2017-10-25" version="1">MQKTRMSTSAAKAAKVKKKLTKEQMQLTILKKKDCDAAALRIVTQLLEPEVDPVWLVENLKYINKCHMEDVIEERAITKLCGYVLCQKPITVVMKQRYQISLKDKKVYDISKRKNFCSPGCFGASNFLLEQMLTSPLWMRDNEEIPKFRILTPSSLTSHGEVVDITITNPCTKDDIENLKETEDDKEEKKPSSDDTIHNMEQMIERTSHESKKGEISENIEDFVLETIKNMNIEKADMKESFDAQFVANKVKQDEKIKPNDVNSSTKVKLEDALSRNKLKDVNVETIIAESKVLEGTKSTDEMIQHKNQESDIIEQHSYFVETPKSQRNSKLNIEQEHVNKKDSINTIKPEILLHWEKTSSIDASKDVKSLKHGKNDNEIEKNRTKQLESSELQTQEIDKKFEKSKIIKKKRSEQKVDPVLNLAAKIEQNFKEWITEDTINFLFGDDSVKQKTIEKIDKQDRYKILCDKLDKLQFQDEQEDVKILEKPKLKPAPHFAFLQEEGEKLDLKVRAFYQGKTVIEEPKAPLSTEENDDTDTFLPLTDVHASKTLRQKIVLEKLDQVLPDLLRTLAGNSEVSVKASLNYTSFRCTAVKALIQTFKLSAKNIIFKTAEWTLVSLIIIKMLSLLDPWLARLLLIRRAYLSMILASYKLDPNYLDLLVASYNPNINLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM34</accession>
    <name>A0A232FM34_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000060">
        <property type="protein sequence ID" value="OXU31417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM34"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="15190" checksum="C996E50BE5D8FA2A" modified="2017-10-25" version="1">MFIALHTRQLAIVYIVIAFVFFFLCVCVYYMAVKCYTIQVDFANESYSCWLESASKEGEKFSGLYEFISTARSLALSSHAKLRDERERASSLKIYTFQFTIRPHNNESSRSLSLPLLSSRMTVAKISGGQLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMD8</accession>
    <name>A0A232FMD8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000016">
        <property type="protein sequence ID" value="OXU31916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMD8"/>
    <dbReference type="STRING" id="543379.A0A232FMD8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17854" checksum="52FC7B1CF2AE3258" modified="2017-10-25" version="1">MSNPDLSDDDASTDEETVIRDFEAEAQLVVNRDTLPKRLADRYNLVYETFQKWKVDNNATTTTESVLIVYFEDLKKRLSPTTLWSVWSMLKKTLNTRDSINIKNFHNLKILLKNNNKGYKPVKAYVLEWEKIMTFLKEEPDNIYLAAKVSTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMS4</accession>
    <name>A0A232FMS4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000014">
        <property type="protein sequence ID" value="OXU31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMS4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="56" mass="6162" checksum="0A9E198044D491B4" modified="2017-10-25" version="1">MLTALANAGDCTRRTLVCTSLCGTYLYSKGSSVYAMPRDAFSTLPRCWTDLARSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMW9</accession>
    <name>A0A232FMW9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_007838</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000008">
        <property type="protein sequence ID" value="OXU32081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FMW9"/>
    <dbReference type="OrthoDB" id="6510378at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000306">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000382">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000098">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000124">
        <property type="entry name" value="Cadherin-related family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012714638" description="Cadherin domain-containing protein" evidence="16">
        <location>
            <begin position="37"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1731"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="157"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="266"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="376"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="493"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="603"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="722"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="833"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="955"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1059"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1176"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1281"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1389"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1510"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU32081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1906" mass="212086" checksum="3ED888A706FBF766" modified="2017-10-25" version="1">MKVLRCASKTDDYSLRRAAPFLLALLLLLLPATCEARNNPPRFLTERGQTAEIVLRLKEGPETPVGSLIYRLRGVDPDGDDLTFGVRDQPGSDVISIDKFSANEANVYLKKPLDRETKDEYAIVLTLTDGKLGDNNFITQSLLLLVEDINDNTPVFKPHPTSLTVPEDAKPGVLTTVEATDLDEGAHGQVVYYLQETEGENDVFSITTVNGKGVIRLAGQLDYERKYLYQLRILAVDRAINEKVNTGSTAILVKVQDVEDQPPEFISMTPVSRISENSKVGTSVLQVRAIDGDKGINNRVTYDITRGPRHLFDIDATSGTVFTTAPLDREAPDNSDGSFILEITVKEESSVLPTPSVSTEVTIILMDVNDETPTFRSSKYIAEINENAPHNTPVNFIGDAIPEVFDHDLGSNGTFKLVIEGDQGIFEVSPTQGINEAPFLIRVKNPSKLDFEQITVVNFTLAAKEIVPNSPKQSVVPVSVYIKDQNDNYPEFTESTYEVSVLENCAAGTTVAWVQALDEDSGNFGTKGIRYTNLGGSLAHALTLNYNTGVITVKQPGVSFDRELVSRHFLTVEARDDLGKGNRNTAQLIVNITDVNDNAPAFLQNKYEAVLLENEELFDAPIVVEAFDIDLNGTRNSEIVYSIVSSDYSRNFTIDKKRGIIVPVAPMDFEALPILKDARSEPSVRALKLTIRARDKGSPSLSSDVLLVVYFKDVNDNAPAFERPVYKKNVPEDLPGGTSVLQVKAWDKDLSSPNNKVVYRIQSGAGDKFVIEPETGTIRVSPGSNLDPDLTSPKTTRYSLKVLAIDSGSEIQRSAQVLVNITIIDVNNKPPVFVDPGTVTIRENTQAGAYVHRIVANDPDIAPILRYRIDPNSSEARNEEGTLIRIQEYDYLAALELNAVDGLLRVVKLLDRERVETIRLGLVVEDLAAVKGIQTASATLNIVIEDENDNDPRFRRPFYRRYVTENSKNGVNIASIVADDADKNRTITYTFESPRELTDMVKLDSETGEVTVANKIDREVHSWLNLTVRATDSGIPPRSSLAEVFIQVIDENDNNPYFVTDVSNVTVNENSKIGTEIIALKARDPDSGDYGKVTYLLDRMSSQGKFAIHPDSGSLTVADTLDWETRSSYVLVIEAWDNYQFGYTAGESRNAFKQIEVSVIDVNDNVPKVEIPEGCATISEFHDVRESIVFVKTKDADNPLMPNGRTNIRIISGNDLGYFTLEQTDYWTARLKASESLRGRFGNYSLKLEVQDLGSPPNKVLATLDVCVTDYNDNPPVFISPQHNVTIRVPENMTVGSEIVQVQAKDADIGPNGDVHYRLKQDIAGHHRTFRIDHKTGVISLKMPLDREIQKLYEIRVEAYDMGTPTPLSSDLDLMIYVKNINDYEPQFLIDVHNVNFTEERPAGFEKVILPETIDRDEVDDLDDPPTKVCYFIVGGNDEKSFDLDTSTHELTTAVSLDRETKEVYEIIIKATEDCNTIPKNQTTFNEKDDTLLKVVITVNDINDNAPKFISETFTGGVTTDADFGTEFMQVKAVDLDIGANAIVKYYLIGSIQMTLTEGFDNIQLQPFLVDETTGGVTLNFDPQRGMKGYFDFMVLANDTNGLHDTARVFIYLLREDQRVRFVLRQHPPEIRSRIEYFREVLGNVTGAIVNVDEYKIHENQDGSVDRTRTDLYLHLVDRNDNSILEVSEVLQLVDRNIEKLDALFKDFNVLDTQPAQPQTMAQFEQAGTTLWLATLTLFLAGLLVVCVGLCLSQRASYQRQLKAANGTLGVTDSEFLRGPGRVPNTNKHSVEGSNPIWMHAYENEWFKSDESISHNSERDSLDENAVNNDEMNEVNTNEITTEDKPYYTQQRVTSIFSVETTTIDTTSDDANEGGSSSRKSPIFRGHNLVLNNVCPLGINVETTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN88</accession>
    <name>A0A232FN88_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000013">
        <property type="protein sequence ID" value="OXU31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN88"/>
    <dbReference type="STRING" id="543379.A0A232FN88"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759839" description="Receptor ligand binding region domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19390" checksum="7616A8E2F78A9C36" modified="2017-10-25" version="1">MQIKIMSVRYLIFLGIIILQYAKAKHSQTFNNPGYFKIGGMLSDGDSEAFFNETIDIILCKALQLFIFLQNLNFASQYVNKGVTYGHVVIAMDSNPIRTALNVCKFLIAQKVYAIIVSHPPVGELSPAAVSYTSGFYHIPVIGISSRDSAFSDKVSNILVRTRKGIPCLLRLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNN4</accession>
    <name>A0A232FNN4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000002">
        <property type="protein sequence ID" value="OXU32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNN4"/>
    <dbReference type="STRING" id="543379.A0A232FNN4"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012805266" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="627" mass="70250" checksum="B984F7EBFC5BD941" modified="2017-10-25" version="1">MGTYKMVSFIICLAITSSYAHRLYLGTSDSLRKNIADLFQGKLNFTDSSIPFNVEELEDITPEYDSEYDFIVIGAGSAGATIASRLSEEKKTNVLLIEAGGKEYPIMDIPRIAGALQLNAQINWMYETESSDKFCLGLTNSKCKWPRGKVMGGNSVFNYMLATRGNKRDFDGWAKSTGDASWSYKNMLTYLKKLENYRVEGIEVDDELHNKKGPLYISSAPYKTKLAEAFIEANEELGLPMNDYNGQEQMGVCYMQSNVKDGERWSANRAYLYPARFRKNLFLTRNSHVNKILIDENTKTAYGVQFTKGDKNIIVRAKKEVILSAGAINSPQILMLSGIGPAKHLGDLGIHVIRNAPVGENLMDHIAYGGLLFKVNDSATYTEENLLDPNDPTIETYITKRNGSLGIGTGFEALSYIDVDNEKLLSNEPNVELLFAGIKGMVDPILSIALGVSDEYRNRFLAENITQSVWTIWPMIMNPKSRGKLLLQSKDPNAKPKLYPNYLDHPDDIKILIGGIRAVIRLSKTKAFQRYGSEMHDVHLPCNKFQFDSDAYWECAIRTFPFTIYHQSGTCKMGRETDETAVVIGVKGLRVADASIMPKIVSAHPHIPIVAIGEKISEQIKQEWRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED16</accession>
    <name>A0A232ED16_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01009329">
        <property type="protein sequence ID" value="OXU16238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7701141at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="259"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="362" mass="41885" checksum="C355C658E204912C" modified="2017-10-25" version="1" fragment="single">SLQRAITEAYEANCKLVRGRGKYEVPWWNNRLEKLKKTTKALLKKAVKSNDYQKWIAWRSKQKEYRYAAAAFIAAHRLENYGLWREKGEHTKEQIKGKDYTVLSIRLDKTVRRYNFEKKYLIQISSREDWSEHDPGLSSGETWYTDGARKKGRAGAGVFRRRPGKRLIVPLGEHATVXITEVEPFHRTIQAAAFIAAHRLKNYGLWREKGEHTKEQIKGKDYTVLSMRLDKTVRRYNFEKRYHIQIPSREDWSEHDPGPSSGETWYTDGARKKGRAGAGVFRRRPGKRLIVPLGEHATVFQAEITAILLCAQLALEEKRQDCINICTDSRAALAALDGSSTSSRXRLAERATPKRMVRQYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDW2</accession>
    <name>A0A232EDW2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005825">
        <property type="protein sequence ID" value="OXU16540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDW2"/>
    <dbReference type="OrthoDB" id="7648950at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="15140" checksum="B1B7079D2AACA802" modified="2017-10-25" version="1">MAEAEIHLDYSNNELFDEMVDKDPTVIEGRKQVKFYFLFKFVLTNGLQRVTCLIWGDELINAYQNEIRIGRIVCLDGAKSKAPVLTQTRRQEWFIAFELIIQNNTSITYHGQHRQMDAGVEVLPQEVTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDW8</accession>
    <name>A0A232EDW8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005809">
        <property type="protein sequence ID" value="OXU16549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDW8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="10305" checksum="FA98BF7B4F2060DB" modified="2017-10-25" version="1">MAVASAEVVMGGSGGGGGGGHTDADCRLAERAFSRMLSESSGSKEKSIALLTVLCMLGKITFNRVYRRFRQAIKRTRRKRSRLIGRRQSTNGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE19</accession>
    <name>A0A232EE19_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005713">
        <property type="protein sequence ID" value="OXU16583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE19"/>
    <dbReference type="OrthoDB" id="10460776at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="12569" checksum="8A9D5ACB2B769157" modified="2017-10-25" version="1" fragment="single">MTEYVKYCVDYYEKKEEPGYKEGRNRYDIRYGNEVYLGEGVLVNLLHWELLQTHKPQIFLVELALLIWRETNLCNRTLDLTRGVKNIPNRSPVKLIEKDLLRLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEA9</accession>
    <name>A0A232EEA9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005498">
        <property type="protein sequence ID" value="OXU16652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEA9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="39" mass="5214" checksum="D92F55B524E76E85" modified="2017-10-25" version="1">MHIYFWILNLVRTVTFYFHSYFFYDHYKFFFQNTILRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFQ0</accession>
    <name>A0A232EFQ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004971">
        <property type="protein sequence ID" value="OXU17154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFQ0"/>
    <dbReference type="STRING" id="543379.A0A232EFQ0"/>
    <dbReference type="OrthoDB" id="8951118at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032452">
        <property type="term" value="F:histone demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="300"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="79415" checksum="054B0734FAD328FB" modified="2017-10-25" version="1">MVDFNPDFVRFREMADLDDAMRLMQAPTAVESDPSVYVFRNVRRRNCYRNMCAEFAKICLAGQPAFSEQRLLCTQEPDFFQNPKMRDEAALVGSPEDLFKRMGVPFRTGAPDLCSLAGTRAFFDQCVRDVASGRHSRSVEITYRLCELPWHHHPARNPDALAAFGVNEPSVYVSGRSFYDLTVTLGDSIGRLRVLGRNISVAEAFRDVRRRNCYRNMCAEFAKICLAGQPAFSEQRLLYTQELDFFLNLKKRDEAALVGSPEDLFKRMGVPFRTGAPDLCSLAGTRAFFDQCVRDAASGRLSPVYWQNTTSALVGITSRLCELPWHHYPARNPEALAAFGVNEPSVYVSGRYALTDIHVEDNYLDSANVIRFGEVGSGKVWLLVHPRSFYDLTVALGDSIGRLRVLGRDDVSDYLEGCPTPANHKNICITSEYLQARNIPHQFITQRPGDLVYVGPGIYHQVINLGISVAEAVNVPFRTGAPDLCSLAGTRAFFDQCVRDVASGRHSRSVEITYRLCELPWHHHPARNPDALAAFGVNEPSVYVSGRSFYDLTVTLGDSIGRLRVLGRNISVAEAVNVGAPRWNAGADRFVTCRCPSNAVGYVPFNPTVTSVVRDRFFRRHVCPTDGCPFTTYLLPHMWAHAQVEYDPDGSSKHHACSLCPKIYKQKCHLMRHHRIAHAPGGTPKKACRWCGDLKSASNMSKHERICSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG22</accession>
    <name>A0A232EG22_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004906">
        <property type="protein sequence ID" value="OXU17262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG22"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10074" checksum="FF55C89DA2FCFBAA" modified="2017-10-25" version="1">MAYYQDDTGPQPYSHHDEVSAQLSRHRDLEMGLNRMAETHTGASNGPVLAEIVAQECREAKIRRQNKQILISVGVSIALIVAVIWFVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGP2</accession>
    <name>A0A232EGP2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004728">
        <property type="protein sequence ID" value="OXU17508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGP2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6816" checksum="BB0D49988631DBDC" modified="2017-10-25" version="1">MKEEWRKYDPTGKLFPKGNGQSSVPILIEFPSDLYAQSRNSYYKKLRTVIKILGLLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGV7</accession>
    <name>A0A232EGV7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication protein A OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004673">
        <property type="protein sequence ID" value="OXU17573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGV7"/>
    <dbReference type="STRING" id="543379.A0A232EGV7"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="2">
        <location>
            <begin position="101"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="218" mass="25128" checksum="55B088951E3C0883" modified="2017-10-25" version="1">MNNIHVFEKLRFSSQRLRFSSQRVQKCKKFCTDHVGVGDFQNLINALVVKARVINIEPFRVYNSGKCFSMILLDNTVVTECSSEIDTKIPMLQYNFVDFTTITTLPKDTIMDVFGKIVRIGDIEFIKTKINVSKREIEISDDSNNTISLVFWNEKAKVIKYKIDDTIIVKNGKVYEFNNTKFISVIASSIIKINCENVPEVKNYESYKLNILKALTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHF9</accession>
    <name>A0A232EHF9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004521">
        <property type="protein sequence ID" value="OXU17773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHF9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14628" checksum="3A6BFE9946F45BC7" modified="2017-10-25" version="1">MVQEDKLKKSQQQVGHAYNITMAYNTPEEFENLSPVWSVTTKLLVDSYIKLYREVLNIKETAKNRIISKFLLPEDLLKGLKIQIKYERPHLELPQVDIHSENLNNLINVNTKINQGIELTITIPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ96</accession>
    <name>A0A232EJ96_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004088">
        <property type="protein sequence ID" value="OXU18392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ96"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="154" mass="17275" checksum="42BF5A2484BA0E63" modified="2017-10-25" version="1">MKKKKKSTTKAASSAVAKDIFVNYKTLFLNASIVYLHVDVLNMDRLLLDGVETFKEYFNSILLNPLYSTSDSIGHSLVARLFLIGLASHQIEHSSLSQVWNGSSLSVTRKSIRRKMVAGQKRHHDSQTQGNQTSTTTKHRCHQIIPMVFGLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJB0</accession>
    <name>A0A232EJB0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004088">
        <property type="protein sequence ID" value="OXU18391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJB0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032135">
        <property type="entry name" value="DUF4817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16087">
        <property type="entry name" value="DUF4817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4817" evidence="1">
        <location>
            <begin position="10"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="135" mass="15460" checksum="509BFEF96D4084F3" modified="2017-10-25" version="1">MADYGPNEIVDMIMILGESRNNYAAAARLYAERYPNRRHPSASDFSRHFGERWSSLLVKVLTPRRSTNDSCMIWRVLPPPPLPSSFSSTRTQHIPLSIANKKCSEIWVLNLHSWEFEAGILPLSHDYTVESILKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK89</accession>
    <name>A0A232EK89_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small VCP/p97-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003848">
        <property type="protein sequence ID" value="OXU18769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK89"/>
    <dbReference type="STRING" id="543379.A0A232EK89"/>
    <dbReference type="OrthoDB" id="10066206at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904293">
        <property type="term" value="P:negative regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904153">
        <property type="term" value="P:negative regulation of retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904240">
        <property type="term" value="P:negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055366">
        <property type="entry name" value="SVIP_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35269">
        <property type="entry name" value="SMALL VCP/P97-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35269:SF1">
        <property type="entry name" value="SMALL VCP_P97-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14543" checksum="57777658D1AAC227" modified="2017-10-25" version="1">MAQDFKTICNLYFQSSATIIKELNISCSVFFFPTALFKARNNLSRNNYLIYCCKGSSSYEDITPDRDIIRQQQAEAAERRLAEQEKRGIGNVNAVKRQQKLAEEREKRENEAGNLNNQAGLKWQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKG4</accession>
    <name>A0A232EKG4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003796">
        <property type="protein sequence ID" value="OXU18849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKG4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="83" mass="8896" checksum="B1B44DCB385ED052" modified="2017-10-25" version="1">MRFTIQADKKLSGLNGSKREGDQTLNGESGPTLPSKIGTNARQNDGHLAEVRGSWWRQSLKSEAPGGDKVCHGETAIVSCELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL53</accession>
    <name>A0A232EL53_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003662">
        <property type="protein sequence ID" value="OXU19042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10667206at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="225" mass="25877" checksum="556030B6FBF2062D" modified="2017-10-25" version="1">MQGGAPVQLKTHSNGNELDGPFPDLRWGQSLSEGSIVKGGGLRRCTSQSHDAYIVSREHLPDEPKSEKEPFCXREQDTVGDFYDEINVLLSSANNALKEEKGEEFKNETMAPLETLAVYLRIWLSEKIKPNNLREAYEETVRLKTRMEAKLIPDSRPYRGRGRYYNNQDNYNGPQNSDNYCNYGGYRHENRYPNNQQNNSDYVGYVNDRTYNGQQQNEPELSPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELB2</accession>
    <name>A0A232ELB2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003589">
        <property type="protein sequence ID" value="OXU19144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELB2"/>
    <dbReference type="STRING" id="543379.A0A232ELB2"/>
    <dbReference type="OrthoDB" id="10034606at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="791"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="944" mass="109187" checksum="F5B3DCD7530FA5E6" modified="2017-10-25" version="1">MYLEVEIFLTTFNVVLVSLAANGRLCSLKSVKKEIPKKRIPLVPYVPPHRRNSSSTNCDKLAPKQSDLNYSDHSYASNKLPKTEKMIYSTNDLSDDDLSVCSRTNTNLKEDIAVHEKQTFKFSNENIEKTSIEIKRSDSQSTIDSDDYSGIESFEMYNTAEELTSESMIFCNEEKESEINAQSPFITEYNASNIKVDLPQKYLNLPVIEKYGKTLRKVKSNDDMHNEESNLSISATHSSGKVFDNVEEVIKHNLIIERILDLANVYMNVTFKVILTELYNKKYSERIPSTVLREINFLVSVNNESKMKDVTPTNKEVVNRGPKFLTSEDIGSTFLVKIYNCKSISEIWGKIMNATNLKKLDELLEEMKKFYDSEKMVASSIKEGGFYAVFKDDFWHRVKCLKCDQSTALVLFIDQGDEYTFSLEKIFELHNKFVLIPAQAIRMSLFDLEDISDCYEAFLILNDKLLEKTVYANMLQCKDNCCNVKLYLKIYEENINIADLVIEQLFKIFLNPKSSIQTEELMPVHVSYISDNKIFVQLFKSKSYAYFTKLLRNATKYLDTKNLQRVQNLNENAIYLVQNPDQKTWYRAKILKFKSEVAVEALLIDTGANISLNKENFYHLEKLSSILTKYPEQAIEVQVHELSKFYEHKTLEHFQKLTKCPVNLFGLFITKILENNNIPTIRLFKKESDNHLIPINDKLFLNQKSEGRSTILIPLNKTESSDDDITHNYQKMLKMREMQRSLSLLSLSTVLDPPKILEHHCDVHIISADNPSNFTIQLLPSKCGSSLTVKTVKIGQLYAAKYDDNDNKWYRVYVCQLMTDTKSANVYYCDYGYYKEVNIENIVPLVSRFHQLPYQAVWAQLYGIKPIFERWTLDDASRFKDLTQLKNFVCIIKSKESFKPQSCQALIPITVETVYSLELVDTSTEDDIYIADILVEERRALKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELZ9</accession>
    <name>A0A232ELZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Daxx histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_010781</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003463">
        <property type="protein sequence ID" value="OXU19367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELZ9"/>
    <dbReference type="STRING" id="543379.A0A232ELZ9"/>
    <dbReference type="OrthoDB" id="7492809at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13150">
        <property type="entry name" value="DAXX_histone_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.810">
        <property type="entry name" value="Daxx helical bundle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046378">
        <property type="entry name" value="DAXX_histone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046426">
        <property type="entry name" value="DAXX_histone-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038298">
        <property type="entry name" value="Daxx_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766:SF7">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20920">
        <property type="entry name" value="DAXX_hist_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Daxx histone-binding" evidence="11">
        <location>
            <begin position="380"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="789" mass="89902" checksum="47A0291EC76666E4" modified="2017-10-25" version="1">MTDVICISSSEDEEDSSKQLSDICQKRKSSISLDNTRSKRCKVDDENKLSSDSNKPNENLPNTDAISPEKDSNEPPINKCISPKPGPSKQHNNEQEFQRSHSDSSSASYKSSPMIKIIKPQLIVRNIIQIPEPSENVFMKFVESCKQKNTSEETKKILSKLKKRFDKLDSHDKDDEEFQMFLKISLQKVSNDSNDKFYTYIQEVHDEVKRRSIRLQLSTSSEWESSTGAEQQTIEETKNPQDIEISKQDMKKVKKIEKTIRICLKRIRELEEKEVDFDAEENSAYLQEDRYKRKLVELCNLLSDIVGDRMLKKEIYKKQIRRKDIPGEMTGISTVDEAIISFINTNIKQVNKLKHIKHPYAIADYLLVPDYPDILDCIVKCDKEKDLKLTKKKMEQLAKTAFKSIGSYLKKQRVLESEEYISSFIDATTEPDPAAKDPELNKRLQNNKKEGDQKLEEIFKKYVDKQEGLSVEELENLNDEESAHEDESDGKSSKANEKKNNLKSEESNTSIIDVKELSSHSKDNSADRILVIEDDDDIQILSDDEEENTESKSNNESGVKSKEKLTILRNTNSSPAEDTTNIFEKEETNCAVVDITKDDNDNIHATSLSTEIRSIKNDKSISTSKSFLDKDNKTKSDDTTKKNEVVLESILPSELTTKNSKIMEINEVGVLPDGHQSSNNTEGPESAENKNSSTFIKVCSFAKPPESWKDTLSPEKAKRNMQLPIQQALQDLSKPQYHALNREKDKKLNFASTLCINPLAANRIDAPPKHVLLENNQCARPQAGNKTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM04</accession>
    <name>A0A232EM04_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomal protein of 78 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003455">
        <property type="protein sequence ID" value="OXU19389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM04"/>
    <dbReference type="STRING" id="543379.A0A232EM04"/>
    <dbReference type="OrthoDB" id="78308at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026212">
        <property type="entry name" value="Cep78"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110:SF3">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02062">
        <property type="entry name" value="CENTROSOME78"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="81956" checksum="A15991B1A216B06A" modified="2017-10-25" version="1">MAEHSFATRYLELCRQKRLRPLPMICVTLPHSLDFTTDRVKMDDWAPILNSLSFDRTLREALINRMNHVTSFRSISVRSKYQYRKLLDDANSETKARAVGKAPVVLTRFLLEWLSHSLTQCVRNSPALNSLELEGVPVPPDCLAVLCVGLAATKSLRHLSFRRCYIGDAGCEVLCRTLGEVQCIRSLDLSQCELTTTAGPALASALSRQKLALYQDAWKQSLRYREPKLESMPGLRRLTLNGNSRLGNEAVASIIEAIRDSLWFKALDLQQCGLSEETGQSILELLDHNKTLVIVDVRLNPNIQQDTLAEISRRLECNELHSKSEYRWLSLPEQKDSSGAKRVSSAGNLPARKSEPLPRPRSAMVRQVKRLPAPVAYRKQPLLQTPTPQLVKRMKTKPPVPVMERRPRLPMKPPEHARVPQPEPPPKVSLHLDLQSQIQSLSDTTQPDANLPLTSEPTPTSQPQVEEPDSSQLDFESQKLEEIAEQLLESRAECDRFLEEIRRNELIIAEERARREFAEAKLRSLQTDLEEIQQRERDSRGYLLISQKSMEEICLSFGRLLDMLERHPVPDDVIDEENNSLARLDVEAAEDRLTKEDIKRRFALIIRKTKSENLKRGYFVDENTVLSRLQLTARHGRSEGNIRNKNPTAVEPLRRFERNIGDTVETVGLPYQDFREHRYEGIRLSSLKAGDGASSPGERARTLFASIVNGDALLGLSQSHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMF7</accession>
    <name>A0A232EMF7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003391">
        <property type="protein sequence ID" value="OXU19492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMF7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="42" mass="4918" checksum="26427A0161552620" modified="2017-10-25" version="1">MCVCVYRNISGTTSSISIKFDMHIYFWILNLGKHLFFIMAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMM8</accession>
    <name>A0A232EMM8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cycle</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003326">
        <property type="protein sequence ID" value="OXU19619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMM8"/>
    <dbReference type="STRING" id="543379.A0A232EMM8"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19726">
        <property type="entry name" value="bHLH-PAS_cycle_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="279"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="600"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU19619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="886" mass="98856" checksum="AE78E6FE59AF4EEF" modified="2017-10-25" version="1">MVVQESQAHSYSEMLQQQLQHQENQEFISIEELRPRADYSGMSSSAVATSSTGGHNVYHQQQQRHHQTYYNLTPVQDIVNNSSSNNNNSSSSNIGSPEASGVPAPSAGLVVASEARPSTESSSSSNPSAAESSSQYQRMETSGPPLAVSTVMVPEQQQQQQQQQQRSAGGSRRHYHNHHHHHHHHSRNSSVSEKTPPPGGSDRSCSVQEMQQHLKKRKVFCHDGSEITDDQGDDAKSVRSNDDSKNFYSIIIYLCDLNTGFFIVIKRTINDESVRLVPWRRQNHSEIEKRRRDKMNTYITELSSMVPMCHAMSRKLDKLTVLRMAVQHLKTILGAVTSYTEGHCKPAFLSDQELKTLILQDGRYRDFVEVKSPQTCSEILIRDQPSGIQPRKVTFPAAEGFVFVVGCDRGRILYVSKSVSQTLNYSQGDLLGQSWFDILHPKDVAKVKEQLSSSDLSPRERLIDAKTMLPVKTDVPQGVSRLCPGARRSFFCRMKRKVDARCAESQIKERADTTTGCHRQKKQQNHDWKYCVIQCTGYLKSWAPAKIGLEEQESEADGEACNLSCLVAVGRIQPPLVAPTSTPRRLRLRNIEFVSRHAIDGKFLFVDQRATMVLGFLPQELQGTSMYEYYHHDDIPHLAKSHKAALQSTERVNTQVYRFRSKEASFVRLNSEWRSFRNPWTKEIEYLIAKNSAVFSDARQVESSANRSEGGSVQENYDYFAQSNGGLERLISSHVEVSKIGRQIAEEVLDLQRRSDQDSSSGSSPTLRPEPALLNAESQITTTVSPDRASDVRQATGSDNSSSNPTPSYNHRNNNVQLDIIASDQGPPGDEDMMEIIGGTTINESPNPVPTDGNDEAAMAVIMSLLEADAGLGGPVDFSGLPWPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMP1</accession>
    <name>A0A232EMP1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003322">
        <property type="protein sequence ID" value="OXU19624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMP1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="13535" checksum="49896DCF8E5D34D0" modified="2017-10-25" version="1" fragment="single">LNEFKPKGTIANQFKLPKVGAVENQVQVQNETIDKNLVKNEEIEFNNVLGSNERKNTEYRFNLKDYLQNISNEESGDESEGYAEGDFLAVEDDKQMKFVNEIRELRLKYIHIITHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMR9</accession>
    <name>A0A232EMR9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01003303">
        <property type="protein sequence ID" value="OXU19653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMR9"/>
    <dbReference type="STRING" id="543379.A0A232EMR9"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011828837" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="27"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="565" mass="63918" checksum="5DC3B7054C215E34" modified="2017-10-25" version="1">MNINVYLISACVLWKAVLASATEKNYPLVATKLATIQGYHKTSYYGRQYEAFEGIPYALPPTGNRRFRPPQPITTPSKEVISATRDPPRCIQFDYQNKETLGQEDCLYLSIYTPNLEKESKLPVILWFHEGAFQRGSGSYTKAKYLMDRDVILVTMNYRLGVFGFMSTEDEVVSGNMGLKDQNLALKWVAENIRHFGGDPKNISLLGVSAGGSSVHYHYLSKMSKGLFVNGMSFSGTALSPWAYDPQPLITAKRLASIAGCTAESTLEMVECLRRKPERALTNATSEMLRQTTSRYFYYPFFMPVAERNVKDCFVNRPPEEILKSGDVYDAPWVTGIVSEEGGSTVSGLAFNQEALSFIDEKWETLTPYMLMYNKTQPLNRHSDIALTVRSRYIGENHELKSNDSITMWGLLDMKTHESFSIVAEKSARLQAAANKNPVYAYYYSYRAAQSHSELLSKTKFDFGVIHLDDILLILENDYVDPSTTSNDKQMLDKMLDFWYSTITTGNPDLGLEWPTVEAESEKFTYMHIAGPTNSSVTSSDNFGEKIFWRKLGAKLLGYIKRYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN46</accession>
    <name>A0A232EN46_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_015734</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01003224">
        <property type="protein sequence ID" value="OXU19770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN46"/>
    <dbReference type="STRING" id="543379.A0A232EN46"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16649">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051652">
        <property type="entry name" value="MDM2_MDM4_MUL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183:SF32">
        <property type="entry name" value="MITOCHONDRIAL E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12183">
        <property type="entry name" value="MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU19770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="342" mass="39033" checksum="8BDC98ECBEF8D6ED" modified="2017-10-25" version="1">MDYLGEFIALGIDSIIFGICLKQYFYCKNSIHAVKNAEFHEVSSSLNDLVQRSPENKIDYIAIRGAVKPIGEPIRSINSRDVTGVIQKLSVKEHVVVRTTSGYWSDQEHTMQEVFNSVPFVLKKGSHQIEVVDAMAAEILDMETISDFFEPSAPNLVDYVWGFFTGHRQRGLQSTEEMLREGSIITGIGELTKSPSKPDSLILQPPVNGTPYYLTTMSLSSLLRKLDDRKKIYRWLCLMFGTIGLFIGGMVLRRYLKDKEEQRLANELRKSLEESRKERRQRVRDKDLRDDQLCVVCRTNPREIILLPCGHVCLCEDCSLDIARDCPICRNKISQKNAAYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN60</accession>
    <name>A0A232EN60_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003218">
        <property type="protein sequence ID" value="OXU19778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN60"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="167" mass="18384" checksum="3FC291D24CD2B944" modified="2017-10-25" version="1">MSLGSLIPGASSMLFSRCLAHYNPSVHPEQVTTLSLALGPRTAQHCKFNAGVDRSRSDLGWDTRQDMPYRGELRGWGDITRGGCVCLACSQSEVIQMINNRLCILHLNLRAELLTITPEPNTTASHHTLENSRIAMDYLAEPRVRATVQNIEASPFTAANPLRMPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENM3</accession>
    <name>A0A232ENM3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003118">
        <property type="protein sequence ID" value="OXU19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENM3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="11158" checksum="DFADA5DBF3AC5591" modified="2017-10-25" version="1">MHALMHDSMYKNAVLADFMMFKCNYCAESVIDILKVTKDEGLVKLFRNSLLSQFSLNSLGSALRTEPYRFGGKKYKSRGAMAKKRTKFGSRQSHSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP48</accession>
    <name>A0A232EP48_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002992">
        <property type="protein sequence ID" value="OXU20159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP48"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="234" mass="26572" checksum="27B6C5B414F50D42" modified="2017-10-25" version="1">MALPILVGNSCFSNVLRGLWITTPCEYSSENAWSIDEANKKMLKARRSISDINSLVSCKRKAHQLETDEGTLRIVREVDEIQCATVSLGERQSLANADNEETESTTVSLRETHFVEICNSLMYNAQSVTLPVIYTGVKCIMFAEWRKNYSSMAKRIVIFSNMSVDVRIFEVTIYIEEILLDVVGIKNIASVDDISRIVSYVANCVLPCQKIDETNKSPNCRECVYNRLQMFPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQZ2</accession>
    <name>A0A232EQZ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_005234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01002706">
        <property type="protein sequence ID" value="OXU20737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQZ2"/>
    <dbReference type="STRING" id="543379.A0A232EQZ2"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="858" mass="98317" checksum="2E33F8617602F6AF" modified="2017-10-25" version="1">MSQSNFQQTRIDQFYKVVSNKNTGCGVKLSPELLKQKSNSSRKSLSLLRKKRNSTKMSNFVESEVQILEQKTSKCSQSLKRTSSSELENSPKKVKSSVADSSPQNTNNQTPLKLRSPNQITSPGKVSNFTPKKSPQKNRNSSSPNKSSPRKLFFDDRINIENVQQAIENLNLLRQGSIVPNEFNLNSVYQCVEFSIVYSDAIIPNAHKFELKDIIFPQEKHADHLLMVVMDVFSNPINCGYFTREELDLIFSLFTLSPESQMLFVRLLKRKLSWHRTSSIKYPEVSSDLDPFFKELVQSGFCTSDLETTDTPVLLNMLQVDEVRTTCQKLKIDHRGNKSLLMERLLKYGNSSKSFFIGAKSPKSVLRSKALTILQPCVCLPEKIINLFDRIFTLLHPVQDPSESIADLFLTLTSVHKGEILFPPIEKQESFPIFQNRAHLISFVESKNALKEILALIEKKDWEAVRDLGQLALRQLSKADKSDCESSLPLHIRKFIPEYTWVKVLSISVDAFKKTPETIQEAVNILETLIAEKSFTQSSQGRWYSELALIEMHHRKDLERSAELTLHALQQVTLTEVDVSGLLERLRKLMRRKTGISNETKSKIQKVQEELENQGIVIQTTRSTTIFATMASRAEAGGKSTWSVTINDNDKYYGSVEMLALQHYTAEKSYHAGLHCEGSLPVTLFAVFFWDELYKTFVPGAFVSKYQDAPLDLFTAEFFNNRKKFIEEKIKFVRALDLDTFTDWMQDRFLNYKQYRSVMSNTLFKNDQHFKEIVTCLGIDGVTGICERLVLNFRLWRSGFPDLILWNSLTAKCKIVEVKGPGDTLSEKQKLWLQYLERLGIDVEVCHVEGMYLDIFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES53</accession>
    <name>A0A232ES53_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002488">
        <property type="protein sequence ID" value="OXU21199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES53"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="31" mass="3755" checksum="F454A6C0673F2900" modified="2017-10-25" version="1">MYKIRRKKKLRARAPTFVIFGFCKQKSAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESP6</accession>
    <name>A0A232ESP6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_005298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002393">
        <property type="protein sequence ID" value="OXU21375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESP6"/>
    <dbReference type="STRING" id="543379.A0A232ESP6"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09869">
        <property type="entry name" value="PIN_GEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041012">
        <property type="entry name" value="GEN_chromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF70">
        <property type="entry name" value="FLAP ENDONUCLEASE GEN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18704">
        <property type="entry name" value="Chromo_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="12">
        <location>
            <begin position="121"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU21375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="84457" checksum="5DE4A01D13E9C141" modified="2017-10-25" version="1">MGVKDLWNILSPLSERKPLFELQGKAIAIDLSCWIVDSQSVTDNIAQPKMHLRNLFFRTSYFLLHDIFPVFVLEGAAPTLKHNTIVKRNDIRHGRETKKTNKKAGRSRFNYVLKECEEMLKYMGLTCVKGYGEAEAMCAYLNEDGLVDGCISQDSDCLLYGAKVVYRNFCTSTQGNRTTSSGSIDEYSMEKIQQVFNLGRNKMIALALICGCDYDEGLSGVGKEAALKLFKIVDDDEILNRMKQWRTDTKFKRMEAELSNPDICTNCGHPGKMRSHTKVGCVDCGTKVKCSDSYKEKRTLISNELAIRKKALIIENFPNQELIDEFLVRKGPVPSELDLKWKKPMIVKFVGFMEKNVAWEPAYAFAKIFPLVTRWQLLNLIEFPIEQRLTTPGVFVPEKIKKIRNIKSVASYEILWLDRDDILEGLTLTSPESNREDDEEESPDALSELATIEPQEIVRKCYPMIVVEFDTQRNAKKKKSTRSRKNKTDENSEEPTEKKKSERKRRGKSKTAEIASNRKIIEFVKVEKQVANLEESLGRMSITPKRRKKNEPIRISSVKKRGPQFDRVMTTERMDAILNGSLEAMFNQLTPEDFASDLEDSTVDMSFIINEICSKKTNEQNICIEYQENISPNTDFHMKYDYSVVKDSEIEHESGFVKNVEENIVIEHQESVLKPADSEEELDEFDLLEKTYVPLHMRLDVDKRKSRIPIRKSLTTDNTEDRFSIGIDSLLNGTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETM4</accession>
    <name>A0A232ETM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_000505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002259">
        <property type="protein sequence ID" value="OXU21708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETM4"/>
    <dbReference type="STRING" id="543379.A0A232ETM4"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000045">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7108" checksum="E51BFE168BBC3BFC" modified="2017-10-25" version="1">MNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETP0</accession>
    <name>A0A232ETP0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002248">
        <property type="protein sequence ID" value="OXU21729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETP0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7869" checksum="C1CDD6549BCCC8AF" modified="2017-10-25" version="1">MHVYFWILNSGKTFIFYFSNYFLFYDQFLVFEKHYFAFFSIIPSLQTIQLICIFCSSGSTVFFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUD4</accession>
    <name>A0A232EUD4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002137">
        <property type="protein sequence ID" value="OXU21968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUD4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="10135" checksum="8D5997759D0E99A3" modified="2017-10-25" version="1">MVYIKEFLIECIKKRYKKLFVNDINKSLVNIIICDIAAIKLFNIDRDIYTTIIKRQNPNLRSIVTITLITPSCCRNNKATRASMNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUH0</accession>
    <name>A0A232EUH0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002126">
        <property type="protein sequence ID" value="OXU22009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUH0"/>
    <dbReference type="STRING" id="543379.A0A232EUH0"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="568" mass="64744" checksum="229936E9C8B51378" modified="2017-10-25" version="1">MALNLDRLNPLHKALLFDDHSSLQRLLKGVNVVEYREEDDSTLLHLAACAFNACFMKYLIEAGCDVNARNDNQDVPLHAIMRFSKGFTETRAPIVKLLTQAGAEMDLKNSLGQDALNLCIGGSDDCDDFYDDLVTAKILLDAGANVNIKDNSNFNDTPLHKAAYRLESKTVDLLLNYEADVNLQNYYGDTALHKVAHTDEMLYGEEDEEHSKQLCILQSLLKKGADVNIENQKGQTPFHYLLETGNQEAIELFITHGANLTIEDYKDRGPLFFAAVNSDASVMKLLIDKGCNIEERDIFDRTPLHRAVKYEYVQNVSFLCNQGADINSADEDGMTPLYSLIEYNKRRQLWWSTSIAELLVDSLIDLGADVNALVFKHKTLLELVQHPATDESRYFVIKLFAKLKFLGIEINDSQIEDIENDEDRFIEYYEKCSSELSTIQNFTFYGTTPILPIFKNNLTILKIYIKNPNLTSAFNSINFSELFPIYGNGMKNIFTIERTRYELWIDAFNTLSKSLPSRISTVVIVQEIMNYLDDKALMRLIKPFDKYYIDSHTKHVNLSSRFEIPVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV79</accession>
    <name>A0A232EV79_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_016105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM214 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002039">
        <property type="protein sequence ID" value="OXU22256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV79"/>
    <dbReference type="STRING" id="543379.A0A232EV79"/>
    <dbReference type="OrthoDB" id="10022292at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU22256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="541" mass="61049" checksum="96E2D0B25294904D" modified="2017-10-25" version="1">MTMAGTFLFFTMVNVMGLIVLYFILPETEGRMLKEIEDHYAGVYSLHAFYEFILTAMAMEMSKAVPVVGYKIFVQLMAKHDPKLSSSSIAKLTSMRNSYQNRKPVGLSLLWSFNQGGRENLAVGLKVWHEVLAPMLEAKSYASYVMKILSDLLKWHSDEETLQSDLYLSIVEDFFSGKLNISQAIIDEGIPHLQKLRTILFQNKSVNYRKLFETLLPKVTSKTPENYKNEVVSALTGCLNNDDRCFAVWKSLYMKNLYISSILLTHIDSNWDSLKPSINSKLLTDVLSAFQLSQEKSKKGKGKDDKYLYSCSNTSEALIKKMSSKKSSKGGFPWKTGCFFLLLIIGAIVAYDTHKHGSFEATSTGKFMRENGITAFAQKTWVSTKLYSAKGLEYLESTSPEYYKAVVDFSTPYVKLAGDFYLVVKNSSVKLYDNVSTYVVAKIPVIQASVEHYVPGLLDSVQKNSLKGVEIVKIYSAWIAEQTVENSVKATRWLKTNVFVGKLSPESLQSYASQAINTTHTFASQTYDWVYEKVQTLSKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVQ8</accession>
    <name>A0A232EVQ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_009504</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001960">
        <property type="protein sequence ID" value="OXU22448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVQ8"/>
    <dbReference type="STRING" id="543379.A0A232EVQ8"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="21898" checksum="486693D169082B54" modified="2017-10-25" version="1">MGSRALLLRCANRLVSGNQQCQYLSSSAALSKNLADVDKALQIHEPSRKNLNDVLVSKTAAEYEKELHGLITVESEVNAVGITSGVPDEHIKTRTVLIYKPAKNAMQSGTNNINFWQISFDTRERWENPLMGWCSSGDPLQATRVNFQTAEQAIEHCKHMGWKYVVQKENKSDPKPRSYGTNFSWDKRTRVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVR5</accession>
    <name>A0A232EVR5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001964">
        <property type="protein sequence ID" value="OXU22434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVR5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="9101" checksum="C2F743658BA9BD98" modified="2017-10-25" version="1" fragment="single">GPPHPLNRYTTNGNLRDHLLPTCEKTRAFMTPKKLQDLVVGTIFARKYVKYFGLDQIDRLLFILAEDLSTAAIQLASVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWK9</accession>
    <name>A0A232EWK9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001847">
        <property type="protein sequence ID" value="OXU22739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWK9"/>
    <dbReference type="STRING" id="543379.A0A232EWK9"/>
    <dbReference type="OrthoDB" id="7699088at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032135">
        <property type="entry name" value="DUF4817"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16087">
        <property type="entry name" value="DUF4817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4817" evidence="1">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="302" mass="35499" checksum="472605BE690A09D9" modified="2017-10-25" version="1">MQVIRTEYAEIHLVYGACNEVGHAAAAEYRQRYPNRRHPDVQTFTLLHQRLVETVSFEVRNPDGGRQRGARDEFDEAILDCFAEDPTTSLRRTARFLETSYSMCQRVMKEDGQHPHKSRCIYEIMECDRENRMIFSHLIVEEHERDPNFLDQILWTDESTHVRTGMVNPHNEHHWAHQNSFLAREDRFQHKFSINMWAELFGNRVVGPWELPDRLDGHNYLRFLREDLPMLLDEVVTPEQQQHIILMHDGAPAHFAIDVSNHLDNLFPGRWIGRGGPTPWPARSADLNPLDYFYWGNSKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXA7</accession>
    <name>A0A232EXA7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_002419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001778">
        <property type="protein sequence ID" value="OXU22947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EXA7"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000143">
        <property type="entry name" value="ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="12">
        <location>
            <begin position="681"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1816" mass="203922" checksum="D61245C3281B558E" modified="2017-10-25" version="1">MRNNSKTREMFIVRALEKILADRDVKRSHLSQLRRACEAALEDLHNEIKESPNNQGEEAPSNALPQPKSDSNFISAEKYFLPFELACQSKSPRIVVTSLDCLQKLIAYGHLTGSIPDSTDPNKLLIVRIVETICSCFMGPQTDEGVQLQIIKALLTVMTSQHVEVHEGTVLLTIRTVYNVYLASRNLVNQTTARATLTQMINVIFARMETQAEEESLKPEPELQNTSISVVPEAESEVTLNQNPDTVVQNIPDAPDIPSQSLDQDAPVMEEEQPPPPAEPVADTTSEAQLIVRSMLDDVINRIVPIDEQPELPETIIIKPVPTTEPEQQPQQQLQQPSTEAEQQPPATPTTPTAPIPPLTPTTEEQQQQQQSANSPVDETQDEAVAESDNMVTAKFTHVLQKDAFLVFRALCKLSMKPLPDGTPDPKSHELRSKILSLQLLLGILQNAGPILRSNEMFVIAIKQYLCVALSKNGVSSVPEVFELSLALFLVLLARFKVHLKMQIEVFFKEIFMNILETSSSSFEHKWMVIHALTRICADAQSVVDIYVNYDCDLAAANLFERLVNDLSKIAQGRQALELGASPNQEKSMRIRGLECLVSILKCMVEWSRDLYVNPSAGAEQQILPAEPPDPPLDSASTNSASGGGNGNGNRLLPRYGSAGSLSSANSSLVGNKEVPDSPEQYEVQKQQKEVWETGIEIFNRKPSKGVQYLQEQGLLGATVDHVARWLHVDDRLDKTAIGDFLGDHNHNQVMYNYIDQMDFADRDLVTALRYFLEGFRLPGEAQKIDRLMEKFASRYCECNPNNGLFTSADTAYILGFSIIMLTTDLHSPQVKNKMTKEQYIKLNRRISDNEDLPEEYLSKIYDEIAGNEIKMKSNPNRPGKQVISSEKKRRLLWNMEMEVISTAAKNLMESVSHVQAPFTTAKHLEHVRPMFKIAWTPFLAAFSVGLQDCDDPEIASLCLDGIRCAIRIACIFHMTLERDAYVQALARFTLLTANSPITEMKAKNIDTIKTLITVAHTDGNYLGSSWLDVVKCISQLELAQLIGTGVRPQLLGPPSKPHFPSPLANFTNLTHNNSHQSNGLNLSSLDREYIYFENTSVSNSYILTLASVKESIGETSSQSVVVAVDRIFTGSTRLDGDAIVEFVKALCQVSLEELAHPTQPRMFSLTKIVEISYYNMGRIRLQWSRIWQVIGEHFDRVGCSPRQDIAFFAVDSLRQLATKFIEKGEFANFRFQKDFLRPFEHIMKKNRSPVIRDMVVRCVAQIVHSQAPNIRSGWKNIFSVFHHAAGDRDEAVVELAFSMTGKIINELYAEDFSIMVDSFQDAVKCLSEFACNASFPDTSMEAIRLIRACASYIDANPQLFAEGMMDDNGMVSEEDRAWVRGWFPLLFELSCVVSRCKLDVRTRALTVLFDVVKTHGASFKPHWWKDLFQVLFRIFDNMKLPEQHTEVNDQNLNKDGSVHNVTFYDTLGPLLLEQLYAQLLWCVQQDNEQLARSGTNCLENLVISNGIKFDKDTWNKTTRCVLNIFTSTLPTDLLTWKPQPSNKESDLDVITGDADSHIGILKRSNSSQSLSAVETTRVKIFAALLIKCVVQLELIQTIDNVVFYPATSRKEDQENLAAAQADMLNSKSEIGVIGTGGDQQKEEQGMYCALPASHLLQLVDCLLASHRFAKSFNSNHEQRNILWKAGFRGNVKPNLLKQETQSLACALRILFKMYSDESHRTDWNLVESRLVEVASEALDYFLSLSSEAHREAWTPILLLLLARILKMPDSRFAVHASSAYAALCEIMCFDLKPELRSALRRFFLRIGPVFRITQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXF7</accession>
    <name>A0A232EXF7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001746">
        <property type="protein sequence ID" value="OXU23042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXF7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="14700" checksum="6B7A34564C4455C3" modified="2017-10-25" version="1">MAIFKHLHMTLEDLMILSRKETRTTIKNGRIKSPPKFSYANAPEPTGPISILKWTPGQARSRSVSPVPRHPSEMIQQGHYGHPYPPMMGPYPYMPPKPYCFYPLGNSGFPYPYMNPYMPYPMNRLCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY05</accession>
    <name>A0A232EY05_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">TATA sequence-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">TATA-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TATA-box factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Transcription initiation factor TFIID TBP subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_014987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001637">
        <property type="protein sequence ID" value="OXU23356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY05"/>
    <dbReference type="STRING" id="543379.A0A232EY05"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000992">
        <property type="term" value="F:RNA polymerase III cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU23356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="306" mass="34361" checksum="B8E13BB053207E95" modified="2017-10-25" version="1">MDQMLPSPGFSIPSIGTPLHQPDEDQQILPNALQQQQESQQQQQYHMQSQMHSMNVLQNNMMQTPQKTMHTYAMNQPFATPQSMMQPQTPQNIMSPLVQPSSQIAPSSMGPSTPGPMTPMTPASADPGILPQLQNIVSTVNLNCKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEDSRLAARKYARIIQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHAQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRQEIYEAFDNIYPILKSFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYY9</accession>
    <name>A0A232EYY9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001573">
        <property type="protein sequence ID" value="OXU23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYY9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="352" mass="38828" checksum="4353231C82009E78" modified="2017-10-25" version="1">MMLMARRRQNANEKNVTTVYIDPKSNDALCTYIKGQQLMKTGDMLETGAESTNCTDAGVTLYSYLLDYRESTQSPGVDSAREGGRLANNTAALLLLDNDIDLAGLCAQRDSEVCFFTCTAIALARWKQEVPLSWDPIIFQALRFVGDDGSYPVDVAVDPGEHVGIAQSAGRAPGADADLDSVGYQRHKPWPRPANVQMLLRVTLGNVSRHLSRPMIGSSMSLRLKLLGPPFCTSYVDRRVNFSSVISSRSLRYLRATPTGQKRREILLVPRILARQLDGLNLVAESRRFAQLEQRDVVVKLALDVVRMQARFASAKGETAVDEAVAADDDDEARRVVLDEAVGRREDPIAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ16</accession>
    <name>A0A232EZ16_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FRA10AC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001563">
        <property type="protein sequence ID" value="OXU23583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ16"/>
    <dbReference type="STRING" id="543379.A0A232EZ16"/>
    <dbReference type="OrthoDB" id="197967at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19447" checksum="0F6276B6F5CACF8D" modified="2017-10-25" version="1">MASHNHSFLSDDNLFKEYCIGDLTNYKHNQIALRWRTEKEVLSGKGESICGNRKCTDTENLKSWEVNFKYVENGKTNNTLVKLRLCEVCSVKLNYTRRSKSHKKGNYDGDSKTGKQDQSKDLASSAKNSNDDVESKKDSESDLWKNQNFQEIEINFDNKMDAYLHDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ17</accession>
    <name>A0A232EZ17_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_009324</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001615">
        <property type="protein sequence ID" value="OXU23418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3666223at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001529">
        <property type="entry name" value="Cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000064">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000076">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000362">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14 15" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013348263" description="Coronin" evidence="17">
        <location>
            <begin position="20"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="191"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="308"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="406"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="491"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="589"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="681"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="780"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="889"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="993"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1096"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="1283"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="1375"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="2025"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="2075"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="2124"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1646"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1887"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1652"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1724"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1771"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1786"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1839"/>
            <end position="1851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU23418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2444" mass="275040" checksum="C38695B5EC5A3A53" modified="2017-10-25" version="1">MSLKIRITLLIGIISAAVSQTAYYNEIEHRCPKPWIMFQDSCYRFIKSFRPREDARRNCLAYQSDLLSINSLDEHGNILRELFLQDPQHRKWYTGIKLQGAYWTNEDGTQLINMENAFLPEKPDNYYGKDYLVYGYSEGLKRWGLEKVNGQDAYYYICEAPAINLQYLHTDDRTYQYGIEINDPLKIPRGPTFTKQPENKVFDVTKRVVNNDVTLSCLADGYPTPTYEWFKEDFENDRLVSKKIDPLSHNRYTISGGTLIIFSPNQTEDRGTYHCKATNKFGTIRSESVELSFGYILEFNLKRPEERGDEHWGKAVYCDPPQHFPGVKYYWAREAFPYFVDDDNERLFVSNDGALYFSTLEKIDEANYSCNVQSTASDTGRNGPFFPLYVSPHLTPQHLKFPNNFPKIFPEAPIAGEQVRMECIAFGFPVPSYNWTRLGAELPRGSYLTNHNRVLIIPKVRIEDQGEYVCRARNEKISIKNSVYLSIQAAPNFTVPLDDKHMDNRGDLTWVCEAFGIPDVTYNWLKNGEILDIYTIPPEDRDRYIIQDNVLKIKSLDPERDEGMFQCEAKNQLKTRYSSAQLRVLSLKPSFKKRPLEPETYAAEGGNVTLICNPEAAPRPKFTWKKDGNVLGSGGRRRITDTGSLIISPVSRDDEGTYVCQVSNEYGNDESRGRLIVLNGPVLIESLPPTIRTAVNLNQTLRCMAYTDEMLDVAYIWMHNDMRIRDKDLKANPHIVINGGQLDIINATFAEAGDYECIVKSTVGRISSRTTITIEGPPGPPGGIQVLNVVKTSVDLSWTDGAYNGRPIDRYTISAKTNWNQTWFNLTEDFTSYTIGDRNTGRKRAHLENVLRPFTTYEFRIQAGNELGYGPPSLPSPQYSTPSDKPIVAPSNIRGGGGKLGDLTIKWDPLKSSEQYGPGIFYKVYWRRKKGESEFQSLALKEHGNVGMSVVPIQSQYYYTEYEVMVQAANDVGYGPKSEIFTIYSAEDMPQVAPQLVTAFSYNGTALNVTWNPIEQTRERVRGKLIGHRIKYWKENGREEDAVYYLSRTTRPWSLVVGLQPDTYYYVKVMAYNSAGEGPESERYLQRTFRRAPQKPPSSVNVFGRNPTSVRVTWRYVQNPNGEEPVIGFKIRVWETDQDMSTAVDTLVPPDAIVAIIENLGVGKEYFLRMLAYSNGGDGRMSSPAHRFRMGDATDYANEETKVAKGSIMAWRFKASKYKNATPIVPKPEACIRDICVGSYQTYGNNIAASAAFMAFNVDHNGSSLAVLPLEDCGRKSKTMPLLHAHADTVTDMDFSPFHDGLLATGSQDCLVKLWHIPEAGLEEPLCNPECTFSHRQRRVEVVRWHPCAEHLLTTVSYTNLSLWDVLSQKELFSNNEHKEVIQSVSWKQDGTLLATSCKDKQVRIIDPRAAKNIVQSASSHQSIKDSRIVWLGNSDRLLTTGFDAARLRQVYIRDLRNLSDPVKTLELDCSTGILMPLFDPDTNMLFLAGKGDTTIMYMEVMDKDPYLVEGIRHSGEQTKGVCLVPKRALNVMQAEVNRVLQLTSSMVIPIMYQVPRKTYRDFHADIYPETAGCVAQNTAAAWIQGHDLPVPKISLDPAKRSKGEEPITVHKGNLATLKNNQQEVKLEVRQQKAIAMSTPKGYTKAQSYIIPEKDDMIPEKNDINEEKEDYKKAEMDKMEDEKSKMQNGSQPVPPKPLPRSSRANSLSEEGAKEEPKPVARPRTTPSPGSIVTPVNPNAIGGYKPRLGPKPFQAKSASQEFSFDKVFSVPQAPSTDSNGHVNNDGYDAKDAPNNDVDKSPTYEAERTKDSEAAKSDSSSIEEDANSSDSGYKPKTPSTAERRRLFEVKDESPENEDSGNFERGGSNRNSIAERRRLYENRSASVTDGNLAEKAMGSPTSMRRRDSFKTKSDIIKEDEVKKVIPMLRQQSMDPRLEKPEPITTPTPKRTSTVFGRVSKFRHLKGTPGHKSTHIENIRNISRQISGECDGFHANSDRVAVPLSGPGGKIAVLELKKTGRLPDGVMPALVHGATVMDFQWDPFNNQRLAVACDDGMIRLWEIPSAGLTEPTNEPNYTIEAHADKIYLIKFHPLAADVLASASYDMTVKIWDLEPLKSGESIKSQITLIGHTDQIFSLAWSPCGQYLATACKAGKLRIYKPRSSDTPIREGKGPVGTRGARVVWALDGRYLVVMGFDKVSERQILVFKADNLNAPLNTVGLDVSPAILMPFYDEDSSTLFLTGRGDSTIYAFEVTEEAPYICPLSHHRCASLHQGLSFLPKNKCDVASVEFASALRLTNNTIEPLSFTVPRIKSELFQDDLFPPTKVTWKPAMTSREWFSGSNKQAPRISLKPPGMDNLTESQGQAVVTAPISAKQNSGSAPASQPYTRLSGYHPDVRAKQLDIQKNMSNLVGDVITCPLEQDYMEGVDEHEWVRLYCLYKVIYYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZA2</accession>
    <name>A0A232EZA2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rogdi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001503">
        <property type="protein sequence ID" value="OXU23772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZA2"/>
    <dbReference type="STRING" id="543379.A0A232EZA2"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32302" checksum="B4E726B07F8C90DB" modified="2017-10-25" version="1">MCRVCVCINIAARQFSNCSDMQATREQMEFEWVLHEEVHSSLSQLRNILMECAQRFPLALFGNDQQHKTDRFVFAAPHDQVKCVVVLTGDSITNAEVNFKVQRQQNANMRTSIQNDHPWKLQQIQDAANHLQQAIAHIDNVDRHYSFKTSDEVMHVLGNILGCLQRSRTSLIVPRKKNLDDLIKSRNMKSLNPNLPENLAISFYIQSYKLVLAVYQLENAHGSVKYETQQAECSVPWLNEALVLLTIALQLCQRLKDKICVFSQYKDFTVGSRVPSALGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZJ5</accession>
    <name>A0A232EZJ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_010687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01001526">
        <property type="protein sequence ID" value="OXU23680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZJ5"/>
    <dbReference type="STRING" id="543379.A0A232EZJ5"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="291"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="659"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU23680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="813" mass="91430" checksum="D54918C117214B90" modified="2017-10-25" version="1">MDNFEEDQRLERQYVDFLDDEQDQGTYTGLVKNMIEEKKYRLIVNINDLRKKNPERAASLLNSSFEELIPFQKALKICVSGIDTEYAKGNTEFFVGFEGSFGNKHTTPRTLTSKYLGNMVCVEGIVVKCSLVRPKVVRSVHYCSVTKSIVERAYSDLTSFDAFPASAVYPTQDEDGNPLETEYGLSTYKDHQTLTIQEMPEKAPAGQLPRSVDVVCDDDLVDLCKPGDRIQVVGNYRCLPAKKNGYTSGAFRTILIANNISQLSKEAELHISHDDVTLCKNLSKSKAQKNIFELLSKSLAPSIHGHEYVKKAILCLLLGGTEKILANGTRLRGDINVLLIGDPSVAKSQLLRYVLSIAPRAITTTGRGSSGVGLTAAVTSDTETGERRLEAGAMVLADRGVICIDEFDKMSDIDRTAIHEVMEQGRVTIAKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDTIDADVDHIISDFVVRMHRYRNPAEQEGEALPFNIGLEYLSTKNPDAEDLQEEETQVYETYDPLLHGKSRKKSDQILTVKFMRKYIHIARCMKPKLTEEACQCISEEYSRLRSEEGVEDNVARTQPITPRTLETLIRLSTAHAKARLSKNVTKEDARAAIALVQYAYFKKVLDKDKKRRRKDSEADSDVEDELEEAHRKPKRTKKQNPPPGEPGHDPYAYDEDDDDYSHVDQVVEQVMRDQHEPLPKGTQDAVTKVASQEIDSQRMQEFTKLLLKMFQEKRTDSLTLNDVCEHANSKMSSPFSEDEIKAALHKMSDENKIMVADDNIILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZS6</accession>
    <name>A0A232EZS6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001457">
        <property type="protein sequence ID" value="OXU23911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZS6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234834" description="TIL domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8217" checksum="EA0B4C7874D995C4" modified="2017-10-25" version="1">MNTKIFLLLLLSIVFTSSTVSAAKECSLHIPFACRVKEQCTEPCKVRLSYVYPGCLLDQPECRGSVCVCHGKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZV7</accession>
    <name>A0A232EZV7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001418">
        <property type="protein sequence ID" value="OXU24046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZV7"/>
    <dbReference type="STRING" id="543379.A0A232EZV7"/>
    <dbReference type="OrthoDB" id="8768722at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000006">
        <property type="entry name" value="uncharacterized protein C16orf52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037663">
        <property type="entry name" value="Mosmo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31186">
        <property type="entry name" value="MODULATOR OF SMOOTHENED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31186:SF1">
        <property type="entry name" value="MODULATOR OF SMOOTHENED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18800">
        <property type="entry name" value="Atthog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="168" mass="18889" checksum="33A5AED8BFF5F846" modified="2017-10-25" version="1">MMDKLTVISGTLFLAADMFAIVSLAMPDWIITDVGGDTRLGLMWSCMTLYNRPQVCYKPDLKPEWWMALVCILVGCILITTTVILLISSHWDRNVIPYARWVGFTAMVLFCLAAVIFPMGFHIDEIGGQPYQLPNSHQVGISYILFVLALWITVISELFAGKVCLPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0B7</accession>
    <name>A0A232F0B7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly factor 6 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001465">
        <property type="protein sequence ID" value="OXU23878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0B7"/>
    <dbReference type="STRING" id="543379.A0A232F0B7"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="10158" checksum="D92265A1DDCC8B36" modified="2017-10-25" version="1">MSFPNKEDRLNCWHNRDQYWHCLDEKKSEDSCNSFRKEYEKFCPAQWVKHFDKKREYLMFKERLEKEGYVPEFPQKPRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0M5</accession>
    <name>A0A232F0M5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vesicular inhibitory amino acid transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 32 member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Vesicular GABA transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_013106</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70983"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001394">
        <property type="protein sequence ID" value="OXU24130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0M5"/>
    <dbReference type="SMR" id="A0A232F0M5"/>
    <dbReference type="STRING" id="543379.A0A232F0M5"/>
    <dbReference type="OrthoDB" id="6021076at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140800">
        <property type="term" value="F:gamma-aminobutyric acid:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051939">
        <property type="term" value="P:gamma-aminobutyric acid import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000062">
        <property type="entry name" value="Vesicular inhibitory amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="20">
        <location>
            <begin position="126"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU24130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="534" mass="59517" checksum="964ACCFA53969601" modified="2017-10-25" version="1">MAYFRGFFIPSLSATMNVAWETIKAKWPENSPCMELIRGPGPGARPPPGAGYDQQGEYREGADGAEMAELNVDAGGSYNGDQRHVTMAEDSFSYQRSGDKVRTGSVSSGFSEFDEGGGEFGSGVKINEWQAAWNVTNAIQGMFIVSLPFAVLRGGYWAIAAMIGVAHICCYTGKILVECLYELDPATGQRVRVRDSYVSIAKECFGPRVGARVVNIAQIIELLMTCILYVVVCGDLMIGTFPEGAIDTRSWMMLIGIFLIPLGFLKSLHHVSVLSFWCTMAHLFINAIIIGYCILEIGDWGWSKVKWSLDMKTFPISLGVIVFSYTSQIFLPTLEGNLIDRSKFDWMLNWSHIAAAAFKSIFGWVCFLTFQNDTQQVITNNLHSAGFKGLVNFCLVVKAVLSYPLPYYAACELLERALFRGKPKTLFPTIWTLDRELKVWGLAWRVGVILFTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHLKLKRNSMETSQVAYDCFVIFLGVLFGIIGVYDSGKELIRAFEIGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0M7</accession>
    <name>A0A232F0M7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001399">
        <property type="protein sequence ID" value="OXU24109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0M7"/>
    <dbReference type="STRING" id="543379.A0A232F0M7"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="325"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="413"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="665" mass="74153" checksum="31F20110AA044108" modified="2017-10-25" version="1">MESRLPKLNFQFKVPARTVTGSTTINSIKSTTASNGTDAAESVTNKPSQTLTKTMSTTNINSKSTTDENKAPLTRAKTMTTLSRTNTATVARGVQKRPGLANNTIEPKRANLRTTMKASVARPVRPATVSGVLPRAAATAATSAAAAAAKTAGPKPNKWDFKGRLEYTSNELTALKQKHREITTEYNNMQDEITSLRESESSNRSKAEKLEKAADVLKKEIEALKMEIDTLQKENSSLVKRLQDTKDLCDQNAASLDQCKDELKVKTNLLTEQVDVITELKGQLEQEKKSNEEKETKIENLTEIVQTMDKDRRALHNYIQELKGNIRVFCRVRPKIPKEAGKNTCTINYLDECTLEVGKLEGEAGNKMKTQRQEFSFDKVFPPNTSQEDVFQELSMLVQSAIEGYNVCVFAYGQTGSGKTYTMEGFPGTDNEGMIPRTVKHIFNEMKQFEMLGWEYKIEASFLEIYNEQIVDLLDYTRKSHEIRMADSKGSDLYVSNLLVQEINSPEELNQCLLIAQENRAMAATQSNERSSRSHSVARIRLIGTHKTKQEVSIGNLNLVDLAGSERLKNEEAARVAETKNINKSLANLGHVILALLQKQDHIPYRNSKLTHLLMPSLGGNSKTLMLLNISPLEESYNETLNSLRFGSNVNNCKTGTIKKVKTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0Q2</accession>
    <name>A0A232F0Q2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001385">
        <property type="protein sequence ID" value="OXU24162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0Q2"/>
    <dbReference type="STRING" id="543379.A0A232F0Q2"/>
    <dbReference type="OrthoDB" id="7699805at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="316"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="638" mass="70863" checksum="C05F990A2432FC70" modified="2017-10-25" version="1">MPSRSSDTEEVGLDGTLAEGGETSQGEAGGVIPIQVSTRSGIVMSDLNANLLSSSQDAAFVRELACELNLKLIDHGPTHPVGDSQTWIDVIYTDDDNVVLSSNNTMAPFSSRHNLIDVEIEFATLAKPRVLHDFTYRDFKSIRQDELLTLLSSCDWLFVAGDDSVNDKLEQICSNLMKYQALAADTEQRIKEARESFIHNRIFEALENNKNVWSELRYVTLLPKVHDELHGFTPDDLNYHFASVSISGSERDANLEDILSKAGAGGFKFREVTFFNVVLAVAHFSTQAKSDEGIPQSVIAKSLPVMDVCLAGIFSTSLSSGVFPSVWKRAHLVLLKKKSIPSAVSDFRPIALLSFLAKVLEKIVYDQILEFISSHRLLDSRQSGFRQDHSTQTALLKITEDIREGIDSKQQLLTILLLFDFSKAFDKISPSKLLQKNLIGQNELLRSDSDWLTTNLGVPQGSVLGPFLFMLYINDLSEAFVKFRGPKGVLESSFDYLLYADDLQVYARVDRDHLHEGIDRLSAVARAVSAWASENVLHLNVQKTQSIIFGSDNNVSKLQEYDLLGIEVQDNVYVPFTDCITEATEIPADEIPPFTEGELIAVTLSLKGGREPGLNGMPAEVLRIVALQRPELLLEMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1E2</accession>
    <name>A0A232F1E2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the JMJD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001276">
        <property type="protein sequence ID" value="OXU24524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1E2"/>
    <dbReference type="STRING" id="543379.A0A232F1E2"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033749">
        <property type="term" value="F:histone H4R3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106140">
        <property type="term" value="F:P-TEFb complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.270:FF:000001">
        <property type="entry name" value="Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000010">
        <property type="entry name" value="bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF32">
        <property type="entry name" value="BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="152"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="398" mass="46337" checksum="A7B6E2EF38EC71BB" modified="2017-10-25" version="1">MTEEFKLDHRAKKRIKEVKKKARPVNNLFTELADKAAWSLHNYSKKFQQFWNFKDNVDRIVESEVPPEEFIRKYEKPYIPVIIKGVQNDWKAQYKWTIERLAKKYRNQKFKCGEDNEGYSVKMKMKYYIRYMQNNEDDSPLYIFDSSFGEHPRRKKLLDDYTTPKYFRDDLFQHAGEHRRPPYRWFVMGPERSGTGIHIDPLGTSAWNALISGHKRWCLFPTHTPRELLKVTGAEGGKQRDEAITWFSVIYPRTKLPTWPQDCLPIEILQNPGETVFVPGGWWHVVLNLDDTIAVTQNFCSRTNFPVVWHKTVRGRPKLSRKWLKVLREKEPELAALAETIDVKEDTGVASDSSSDSSSSSSSSGSSSQSEDSEDDSGQESLSAHKKKKRRKLNNGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1K4</accession>
    <name>A0A232F1K4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Voltage-dependent anion-selective channel protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001295">
        <property type="protein sequence ID" value="OXU24453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1K4"/>
    <dbReference type="STRING" id="543379.A0A232F1K4"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30393" checksum="10AFA696B7E2B9EC" modified="2017-10-25" version="1">MSVPDYGELGKSARDVFREGYAYDLAKLKLSAKLGVEADVAFDLRKSELTGSFLGKYSANGYGQFTGKLSSPSALTGEYKLNGFVSENVDLDVGYTFNLADKFQTCRVRGKFHNSLLHADGSITKDLDGDAVLHGSAVLKLGKLLLGYQAELKPNGSRLSKNDLTLGCEIGSSAALHLRCLRIPKELGLSGFYSVNDKLDVAVDAKLGIGDESRPWYLGAGLAYKLDNQSKLRLKLDKNIQLGTSLQMPLNEEAKVTLAMSLDLAQPASGQHKVGIGLDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F296</accession>
    <name>A0A232F296_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_015110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001179">
        <property type="protein sequence ID" value="OXU24841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F296"/>
    <dbReference type="STRING" id="543379.A0A232F296"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="81"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="576"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="89974" checksum="6EC43A7D37067628" modified="2017-10-25" version="1">MFRFINRMQRSRSAASSIGAQLARSYAPATTMRRLVVSARRCCYSGTAAASMMVLLLLGLISLAAAAYDLDAFVENVNMNPCEDFYTYICESQYKYPDGSVSSFKSLVAEAQDNVVAKLRGEFIFSTFGYYNRIPILEDDDAQNVYAAKIARIFYASCMDTETIDAQGIIPIESVLKELRGWPLTRRALDNEKLANWQDLHAFYSKINVFPLYEIAVNNDALRRTHTILVRRTDFHSIETSVRTDASLFLCRQLRQPKPVIREPLLYKAKSFYKYVDYIKSVAMVVANLSETNVSEQEVATGAKQVAAFEAELSKILEVSERLDFYRPILLGKFQNITNQLSRDKNNTLDWVKIINGMYPSTTGLVSLQQSIDISTLSYFPRLIQLLYNTPSRTVVNFIHWRFVHQFLPHTSGELRNSYFEMRNFMHEPVKNMPRWRFCGFEPTFDHVISHIFAKKHLSAKTEKYVQRVLSDIKQVTLRTIKRSSLLNEDEKRMAERKILSMSFVLGIPEPLKNLSVVNSYYKKLTISKNYFTNVLTLRKFYKLKEFEAVKKNEFKSSSDINFMKITTISSIGSAYEFFENRVLIKAENLMAPLFDPDFPEFKKYGILGFIIAYEIMHAFNDADSIEGTRPRRHLYSEETKLKYWNKMECFINQFDNYYIPDPFNVEKHVYVDGERSAMENIADSTAIQIAFQAYRERSRKQGVSSIEDDEDLFASFASLLCRPELEEFYLSRFNLALRTLPRFRVIGSLSNTNEFAKTFSCSSGARMNPETKCNFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2C8</accession>
    <name>A0A232F2C8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tonsoku-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_000170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001235">
        <property type="protein sequence ID" value="OXU24659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2C8"/>
    <dbReference type="OrthoDB" id="273147at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052311">
        <property type="entry name" value="MMS22L-TONSL_complex_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46358:SF1">
        <property type="entry name" value="TONSOKU-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1311" mass="147342" checksum="E82F5E7879480FC7" modified="2017-10-25" version="1">MDEDSLLKRKNKAQKEGNGKVLADVQKKLGDLYYDRKQYEDALKAYKGQLQACECLNDKLNCAIAHRMIGEVYADIGNFNEALNHQSLYLEIAKELQDLTEEQRAFATLGRTYLLVADSLVKDSETNKKMEVLRDAKKAFSKSIKLCDKLENKIDVTELMMMRARLLLNLGLVLEQQKDTEQALNLIKQAAGLCRKHNLHEDLHRTNIALAGLNERLGNTELALKKLDDAAKVDDIYLKVDARLLKAELLLKLGEWMEAQKLLHTLYKSKKLLEPIRQQVIKLLKIAVVLCKTEDKLLTESSPALKEKFYEKMGDAATAVKSLDKAVEYYRCMLSCAEESNSSQLGAALTSLAQTLRDAGKLQEAIPYARRELELCKDPKEACSSALYLAGLLTEANCSSPEVRQMFERALSHGKKVGPGLERTVLREFIEYLEKMEDVDLAEITRLNEELESLPKEEDDDDEEEENTPDIGVDVCLEELSDLEEEVPAVALPARNIARHVNRKGRFCIKKNEKGETQLHVACIKGNISAVEKLLEEGHPTAVRDNCGWTPLHEASNHGFVDIVGVLIRHGADVNDPGGAMSDGVTALHDASANGHTAVIQLLLNSGADANLLTKTGDTALDCLEQWRQRVGDLTPTELKEYVVAKRRLQAMTTVTGKKKKKKDLENRGWDALVDDEEEGGTTPERGKTIEDYAKREKISAGEDYKRTIAALHHPGRQQLKVQSKKMSRITAPLLDSEDMLVNDDWLEDDLGIAASKHKDKAPSYFANNGLPPPTACETNLGSTKRKSKNDVDEDDAIFEVDKNMKRQKISVERELVKKAPVIAMDEDSCDSDKTVDDWPKQKKPRQMSLLKQGFTKNVCSRSPSPTLLISPDSVFTPAVHQERHSWDSGCISETVDLDIVVDSESFELKLHLRDLRKTMSDIEELIKHKFEAKTGCRPKIKFKTVDGIVLADQVSLVEVPRDRNKLKLYGEIAQNDLLPIVDRYKKVCETLCADITDSMLKSLRSCDNTSSFRLNRLDAEKSLEPLLKCLRYQSNLRTLNLSGATFFNIGNLLNRAIAQLSRLDELHLQCCDLDFKCLSCIEALPISIRVLDLSYNPLTGRCQKILYELLKPLERLQNLALRYCELDDFRFVVTSGSLVNLDLSWNPIGGQGVANMLQRQLLSLNISNTQNFIGGRVNVIDKIFFSDSLVSFYTLESLEIGSCQATDLDVEKILSQAPNLTRINVSNNINVTKTSLCAILQRNPTMTYINLTGCRLVEEPPEANLKITSPQVCTLLVHMRHDVIDAWENLWQRKGYSKKLPHSLVMFKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Y6</accession>
    <name>A0A232F2Y6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001105">
        <property type="protein sequence ID" value="OXU25114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2Y6"/>
    <dbReference type="STRING" id="543379.A0A232F2Y6"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="686" mass="75750" checksum="29D8AAD413462305" modified="2017-10-25" version="1" fragment="single">GVECEDEVYSVRQLEARAEQLKEEPKPTAVVPPRKPLVDKPVSVTASLFQSFQERAAKQQSRNLIDVGKENDERQDTAKAKTNVPVCEVDQPKPQQQPPPAYVATTSIPDPPLYRPAPQTATASIFAPRTKDMNKGFLTFSEDQPGLTSQYIASPLLVVYYIVAVIFRNERTFHIPVLKDEPEDLTHLAPTAGDVCVPLEDPPFLSDMLDEFILNANYCPLLSPELSSAPSELTDVVRNSNSNQSSGKDVEQTILGDSLRRDDCNSSDGDPFIYRDSPSRCSLGTDLHSPTLTKSPEGSGIGDSLNSPNDSGGGLSEDEMLMLSISDVMADDELALRAPYIPMSDQDEALQMLISDDMVMWGPSQSNEKKCKWLTDAGEENANSSLAQLLTDESSSKKMKDHAGILVNPTHVLGQISLKNTTKDSTADRERANKRVHAYSKSSHESKRVKHNDVPTSNNNNNNNGNISSFENILSSSVQSSQLLQQLVSQQVPKNRSWPDQLSTTQESQRTRSNNVNGNSLYEESNLCRLNDESVGLSNPRKNVFEHDGGGRPTSQRQQQQQQQQQSNSVLMNLLVSGCDMQNIQSQLQDPTSFLSNPPLLLDQDKISPLQISVEEQLQTVPQWTNNSSTLGIEHQHLSPILMRDKQQIPQPTTVGFEALGYDDDLGFMSDAQNDDLFRALDSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F384</accession>
    <name>A0A232F384_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase subunit B14.5a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001155">
        <property type="protein sequence ID" value="OXU24950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F384"/>
    <dbReference type="STRING" id="543379.A0A232F384"/>
    <dbReference type="OrthoDB" id="10063829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009947">
        <property type="entry name" value="NDUA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07347">
        <property type="entry name" value="CI-B14_5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="53911" checksum="81AA2EEC4FA70876" modified="2017-10-25" version="1" fragment="single">KALKANSLRFANQIAARTQLQPDLPGGPYKKSTGIYYYTRDVRREVKPPITVYTANQLALSLGLSDNPQTVTDLTRSLLCVSEGHLSAERPTGRPMASTRASEAVGGVLVYALGHLRALSSAGASSVSQFSDNTRDQAKRLIDISQSSRALQLRFIFSRVTYVHNVINTVRHTLYIMYYESSQHYQPIFNLVATAGSRGYFILCNKKVTNEKNHKCPNKCRSYLQKPPCERDQTDRHVVSPHCNRIFFSQMCLLNHLKSGSFDENHTVCASLKICTRCCRMIRTLSNDTTSHICDAVFFKVCKLMQPIVHLCFMRPIAETCHQVASTTTRKQILYLFYDFETQQSEPVLEYIDEFFAEKTYASGYRPECRNDNEQAIDRYIQNFEQEEGIKLDKSRIKFNAGLRSVAKLFNSLWEKFGQRGNMTKTEIVRDPQRLFELLTSPDKVVNSILPTNDEILYISWVNNDECAGHANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5H2</accession>
    <name>A0A232F5H2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cathepsin L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000962">
        <property type="protein sequence ID" value="OXU25713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5H2"/>
    <dbReference type="STRING" id="543379.A0A232F5H2"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="157"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42669" checksum="ACDAEECDFACC8A35" modified="2017-10-25" version="1">MYNSCIHLSLHGHWTRFSEYKERMSYIAMTRGIAGVLVLLLLILDCARSAPSAANNRSFVEDDDWAAFKLRYKKNYNGDVEENFRRSVFHENQRKIAEHNQKHDLGLFTYKVRINQFGDMMFEEYKNYMHAANNTITQLKRIPRGEEFIKPKSAEDVPEHVDWRQRGAVTPVRDQGLTCGSCWAFSAAGALEAQYFKKTGVLTALSAQNLIDCTMEYGNLGCGGGSAALSFQFVVDHKGLEPEANYSYEARTKECPYNTSDDEDEQLEASFIYVNGGDETTLKVAVATVGPFSAAIDGSHDTFRFYSEGVYYQPECNEDDLDHAVLIVGYGTDNRTGQDFWLVKNSWGETWGEGGYFKVARNRRNHCGIAAAAVYPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5M7</accession>
    <name>A0A232F5M7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_003209</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000946">
        <property type="protein sequence ID" value="OXU25788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5M7"/>
    <dbReference type="STRING" id="543379.A0A232F5M7"/>
    <dbReference type="OrthoDB" id="10003593at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09232">
        <property type="entry name" value="Snurportin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Snurportin-1 m3G cap-binding" evidence="12">
        <location>
            <begin position="141"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU25788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="371" mass="43688" checksum="29DAB0DF8F0A83F2" modified="2017-10-25" version="1">MATSLAPAIGNSKGNSFDSAENENDRDRLGISSEAVDKKENFNERLAFYKKPIKKNNCKLEFDVTDTPQEIRRQRILYYQRKNRDASFNAGRKFLQNVLNSDNEEAMEESVELPEEALEDMEIDVSKKKKYKIRKDYARMFMLSEWMLEVPQDFAENWYMVPCPVGKRVLLVAQKGLTRLYTRKGIEIAVLRTYLPGGNHKRCHNSFTILDCIWIPNKKECYVLDVLAWSNQELINCDTDFRFYWLKSQIEEHPELQTIRKGVNDCSVIQLPYLSCDQPFYDCLQNGLLFYHKQIPYTNGRTPLVTWLKVYMLPEVLNIHIPEELEEKPASYVDFETHVLKVIRDEKIRLQNRQKRNEQLDNSLSELEDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5R6</accession>
    <name>A0A232F5R6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_007966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000942">
        <property type="protein sequence ID" value="OXU25803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5R6"/>
    <dbReference type="STRING" id="543379.A0A232F5R6"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012579198" description="Chitin-binding type-2 domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="319"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="429"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="526"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="588"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="697" mass="76131" checksum="AE673EA4C915E546" modified="2017-10-25" version="1">MKHSIFLLVALAISASRGANGQVKPHLSLYDEGEILPVPKECPKNHDPAYTVHIAHETDCHKFYTCSFGKPVEKTCPLGLHFNPRKQVCDNPASAGCVSGTGSSSTPTTTTTEAVPTPKPTTTTTEAAPTPKPTTTTTEAAPTPKPTTTTTEAAPTPSYPTSCPAVDPEEPIVLPHECVCEKYYKCRNREQILQQCGSGLHFNPTSHACDFPSNAGCVSTPAPTSPIPIIPGECPLVNGDYVVHLPHENKCAFFYKCDNGHKVLFECPDKLHFNPTLDVCDWPNPEMIISSLNRYKFVILALAFITLLVALAISASSQANECPKTERLLSYIPHETDCDKFYECYQGEKTVMSCPQGYHFDSKKLTCLPASIAESRHFLIQRFTLINQLYINVLAPIFLLIVTLAIDASNSQAKQYVISANEEEIVSVPTECPKIQDPEVTVCIAHETDCDKYYKCLSSGEKILMHCLPGLHFNPRKQECDWPPLVTDYSIFLLVALAIGASRGANGQVKPYFINRYEVGEILPVPTECPAEQDPKVTVHIAHETDCNKFYTCSFGKPYLKECPFGLHFNPRKQICDNPASARCVPGTTTTTKATPTPKPTSTTTKATPTPTQSTTTTLKPTTTTTEATPTPTEGITTSTTITTTEATNTSTEETTEEITIPSIPSHGIIINIFIKNSTIIFKSPLVEESFSTSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F600</accession>
    <name>A0A232F600_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_010535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000924">
        <property type="protein sequence ID" value="OXU25878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F600"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="10">
        <location>
            <begin position="123"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="10">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="10">
        <location>
            <begin position="412"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="709" mass="81392" checksum="52727EBE1F98D5E7" modified="2017-10-25" version="1">MRLSRRRFIFIFAIIILIIIVVRLLYKKKYGSATSTNARNFLRNQRFETWIDTYLSKESADLGDFGEPAYLPDSENHNGSLVYSDKAVNVVLSNKIPLRRRIRDIRDPLCKKVTYDTKLPTTSVVIIFHNEAWSLLLRTVYSVLQESPTKFLKEIILVDDNSNEEELKGILAYYIETRLPKKVKLLRLPKRQGVIRARLAGAQQATGDVLVFLDAHCEVTKGCKESADLGDFGEPAYLPDSENHNGSLVYSDKAVNVVLSNKIPLRRRIRDIRDPLCKNVTYDTKLPTTSVVIIFYNEAWSLLLRTVYSVLQESPPKFLKEIILVDDNSNEENSAISTLSGFQQKSLRVYWRITSKRVYRRKSNYCVCLSAKASYELVWQVRSRRLATFWCSLMPTAKCKSVTYETKLPTTSVVIIFYNEAWSVLLRTVYSVLQESPPKFLKEIILVDDNSNEEELKGILAYYIETRLPKKVKLLRLPKRQGVIRARLAGAQQATGDVLVFLDAHCEVTKGWLPPLLHRIKARPNAVLMPAIDLIDSKTLGYKLSARGLHTPIGGFKWNGDFTWINIEDSPMRRPTSPIDVIKTPTMSGGLFAIDRKYFWVIGSYDELMDGWGGENLEMSFRIWQCGGSIEIVPCSRVGHIYRKFFPYAFPSNKNTYLINTARAVHVWMDDYKRLFFLHHKDMEGNTKDIGDLTARKKLRERLXGASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F684</accession>
    <name>A0A232F684_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000866">
        <property type="protein sequence ID" value="OXU26145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F684"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9374" checksum="BC94001EBFA10C74" modified="2017-10-25" version="1" fragment="single">MKKQVRATEQWLLLGAFEGPRKQCHKALFECWNMVLHCSKHILSENNCKRPSNENFNNCFDGLNVIALLQAEMLSRQVGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6F0</accession>
    <name>A0A232F6F0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000849">
        <property type="protein sequence ID" value="OXU26215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6F0"/>
    <dbReference type="STRING" id="543379.A0A232F6F0"/>
    <dbReference type="OrthoDB" id="8067855at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="20255" checksum="B0136A3708BF673C" modified="2017-10-25" version="1">MQTDEALYAELDSQAASYASGSEDKHYHELDAVGLHRQHQDTLCTRHSQRCIEPDYEMYENDPTTVIPPPHLHHHHLHHHHHYEESKQQQPQPPAPAPAQPSYQNTGYTGSDAEPDGPSTLSSAPSSAYYSDLSSNSANQQLMIGPGLAIVHPEGDAPPVYEPAPHYRLTAINESTTCPSDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7A5</accession>
    <name>A0A232F7A5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_003062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01000778">
        <property type="protein sequence ID" value="OXU26555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7A5"/>
    <dbReference type="STRING" id="543379.A0A232F7A5"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="377" mass="40515" checksum="96B9F46501BD1F44" modified="2017-10-25" version="1">MADTTGKVIKCRAAVAWEAKKPLTLEVIEVAPPKAHEVRVKINAVALCHTDAYTLDGLDPEGLFPCVLGHEGAGIVESVGDDVTEFKPGDHVIPLYVPQCRDCKFCRSPKTNLCSKIRMTQGKGVMPDGTSRFTCNGQTLYHFMGCSTFSEYIVVAEIALAKINPSAPLDKVCLLGCGVSTGYGAALNTAKVEPGSTCAIWGLGAVGLAVALGCKTAGASRIIGIDINPAKFEKAKAFGCTEFVNPKDHTRPIQDVLIEMTDGGLDFTFECVGNVHTMRAALESCHKGWGVSVIVGVAAAGQEISTRPFQLVTGRTWKGTAFGGWKSKDSVPQLVHEYMTKKLILDEFITHNLPFDKINEGFELLHSGKCLRAVLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7X8</accession>
    <name>A0A232F7X8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000777">
        <property type="protein sequence ID" value="OXU26559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7X8"/>
    <dbReference type="STRING" id="543379.A0A232F7X8"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="548" mass="61210" checksum="6021B0F9AC8D44E4" modified="2017-10-25" version="1">MGSENKDAVDEFARPRRPKLKKKRSRTDSEASTASVEIKSTMLVDPIKRKRRNIYNPEEESRLERLVFGDPSDIIQNLKSDIESEAEPEPMLKHETSSDSSESEPEPEEDDDADDDDASVIIQSDKAASIITVDSKSTVTAGTAAWMDEDDEELLQDALIEQNRRLPKGRTEKKYSELLQNKYSHIVGTPKWAKLNRENDEDSDDSDSEILKHSNHIVPKKTKALSKGNIDLKVLTQINKQTHMEGPFVNSVQFHEQSTVALVAGSSGVLSLFEIDGRENNKLHTMKFHRFPIHTARFLKEGTEVLVGSMSHAFCHSYDLIGGKTQRIPLPHGITNMKKFEISPDGKLIAICGRLGEIHLLSSKTKEMIGTMKMNKKCRSLAFTPDSTKIISHGESSEIYVWDVKSRTCNNRAFDDGCLSACSIAMSPSGQFIATGSKQGAVNLYDAKSVLTERTPTPVKTVLNLVTAITKLEFNPTSEILAMASDRKANAFKMLHLPSFNVFANFPTFNTKMFNPLDIDFSPGSGYMSVSNNKGFAYLYRLKHYGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8Y3</accession>
    <name>A0A232F8Y3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000702">
        <property type="protein sequence ID" value="OXU26903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8Y3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012692050" evidence="2">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9527" checksum="AF1C03F228113F12" modified="2017-10-25" version="1">MKVLIVFAVCTLLANTYVATLDVYDDPVYGLVISSSNSITLYYAFPLLLYAYFYTCELAIVSWPAVNCIKNTCPKLEKIERANST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F907</accession>
    <name>A0A232F907_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc transporter ZIP13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000669">
        <property type="protein sequence ID" value="OXU27082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F907"/>
    <dbReference type="STRING" id="543379.A0A232F907"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="47534" checksum="8A76E96D66A2FF75" modified="2017-10-25" version="1">MAASGCLSNCTRPGIFEHEWTADELWAPWNVLADYFEYQPWFFSLLGSAMVGLSGVFPLLVIPIDEAADLKHGDSAKTLKILLSFAVGGLLGDVFLHLLPEAWENHAAANTAKGSGVNHASMGCGLWVLAGFLVFVVAEKMFSGVGNPDDEDDNAEEMGRENEAVATIVPKKTNELENNNCDGQLGDCPKLGNNGFANGDVTKINGLKNGLRKVNGIDYKKFNGYANGFAKINGVKNGFCADAREKRTCLESFFIRNSILLASVLLDFADQQLSEKSSSEEKRTRERPKPKHVIGYLNLVANCVDNFTHGLAVGGSFLVSFRLGALTTFAILIHEIPHEIGDFAILLKSGFNRWDAAKAQLMTATGGMCGAFVAVVFSGDAVESRTSWILPFTAGGFLHIGLVTVLPELLKETDPWESLKQIGALLSGISVMAFLTIMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9A5</accession>
    <name>A0A232F9A5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000640">
        <property type="protein sequence ID" value="OXU27245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9A5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="13790" checksum="46BF17F2099400F0" modified="2017-10-25" version="1" fragment="single">VVITSAGLLIDLSRFNGCQFLAIHLAGVRLSSAAETTSGESFENALSRVRPCQALALFSNLDGELLPEKEVEEHDGAQRPAAADPPNRKCPYATYRRYQRLEELKRWEKDRSRTVFCSTAANGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA79</accession>
    <name>A0A232FA79_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000546">
        <property type="protein sequence ID" value="OXU27754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA79"/>
    <dbReference type="STRING" id="543379.A0A232FA79"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="190" mass="20986" checksum="2DB96CFB3A73173C" modified="2017-10-25" version="1">MAQNKLNDFANRFGKGPAGINLGIKILAMTGAAAYGVSQSMYTVDGGHRAIIFSRLGGVQKDIMTEGLHFRIPWFHYPIIYDIRSRPRKISSPTGSKDLQMVNISLRVLSRPDAIVKIHEKEPLFNGMYSNSGGSNDNFLPKQPFLPTKAMAIMASNTLILVQTKTTLNTKTTLNMLDKMANIKLASKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAA0</accession>
    <name>A0A232FAA0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000618">
        <property type="protein sequence ID" value="OXU27368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAA0"/>
    <dbReference type="STRING" id="543379.A0A232FAA0"/>
    <dbReference type="OrthoDB" id="5804096at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF1">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082218" description="TM2 domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="185" mass="20843" checksum="316566C36CA9C01F" modified="2017-10-25" version="1">MIRFIKFCCVILLLLCVPLSNGADYKYEIDCNNLRMGQYICPHPDYDFIDPKTQQPKGCTKENKAKVVCQAADGLICSETKNNTFKKDIPCKWTNGYSFETSLLLSIFLGMFGADRFYLGYPALGLLKLSTLGFLFLGQFCDVILIATQIVGPADGSHYVMPYYGAGVTIVKSDNFTYRVPQYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAZ9</accession>
    <name>A0A232FAZ9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000494">
        <property type="protein sequence ID" value="OXU28011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAZ9"/>
    <dbReference type="STRING" id="543379.A0A232FAZ9"/>
    <dbReference type="OrthoDB" id="2436455at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1154"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1191" mass="139757" checksum="F63F047FB90A24F8" modified="2017-10-25" version="1">MDSWEALVIQWVNCLHENSNDYVRNIEELKDGRIYWNLINKLKSWSCKEYSDCQRDMVFEFLTEEYPNFACNSTSDIVDNLCVGLLVLSRLSLEPVFHKSLCVNLSYEMQIKIKSILETIYALGKNVTVDELCKTFSLSDKTDFKSLSTRSKRILEEFLNSPVVKSVQSEKKMYEQTRHIRHLRADIETLRYEKSELIEDIKVQKKQIDELQNKLQDTLSELKLLRANTADPDNYDSTQEQMDLKSIELSYKNELKSLEKYVAELQNDNCKLQDEKKDLISEVKLCKAKCRTVEEKNTNNDQIIESMLFQIEKKDDELTELKMRYEELRNYVKEKSVQLSNQSFEFDDRMISETSFNKSEALSSVIEIQLQDTKKDLVEMQNAFKDVNSVCTVLIEEYAKLKKKYDILFTLKAEVKDVEPSKCEKCDLREKEEAQKIVRDIHNIVPVELQKELKCEKCDLREKEAQKAVSDIDNIEQLEPQDDMKEQYVVAKLESNKKIVKNEIKLSFADIFKDNLSNRNNSTFVMELVNQSDKYKGIKTLKNNISFALHKNTNEDLFACKDTFYNSNNLTENSEDLEKSKTLQVYKENKNINFIDNNSIIVKFCKVLCQENWNSQLSDFVQILNRFIQTEAGVMVEENHVLSKVLDYKELVETNDRDTQTEMNVQRYSKDTQTEINVQRCSKDTQTEINVQRYSKDTQTDKECNRRLSFYKNNLEYLQSIWVSLRESAFHTFKIYKVLLLLDKNWNLVLESSEDVIDKSKAQPEYKELLEKKAIIEKELKNAHWKNLETLSLNLINSVQFVTLLNNTNDCLPANNENLEDWFSNQLSCFNLKNCEKSKKEHQTYIASKIINIKRRLDNYQYLTRLIEKKRAQSSAEPIVLEDKEKQKSADEKLIKEEDISQSKQFQNYVKDIHEKYELKLDKMKEKMKSVYNNQISAMKKEQEMLAMSKLEALQSKFEQQCFNHTEDLKMYKKHISDLSTQLWDVGEKLIIERQRKEEAVQELKKMKSKSDTIESQHPKSLRYDQENFDESMVKPEKAVNALQSIENTSVHKMQSVRGFQIMGNAFKTEDEEGEVFDTTYLADMQRSRNSVSSADLNRLSILQMRNSKCKPHLKSSYPGELQIAPIPFSEDEIKTGSTSEEVFNDSLSQSLLTGKKVKRSNRTRTGTETPRRSRRFSNIFRKPRLSMDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB80</accession>
    <name>A0A232FB80_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000511">
        <property type="protein sequence ID" value="OXU27915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB80"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="230" mass="25134" checksum="FEB418D3715286A4" modified="2017-10-25" version="1">MKNQLSESKSSLEKRMTAIEKSLEPLKEIPVLINRDVAALRAEQEEIKSKLEQLLISGAGSSSSPSNAPALCTEIIQQLREVNTRIQVQLDSVASFQAKLSAELVITGLTFSETTSLRHLAYATLWPLDAELTERDIISVRPLGRMRVARNDTVDASGASPGAASLPLSVSLSRTLMHSLISAKIKIRKLQTTQLSSKLLHKARFALPFRIRSSTSTNGCCLMSFGFAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBC4</accession>
    <name>A0A232FBC4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000474">
        <property type="protein sequence ID" value="OXU28131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBC4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="177" mass="20332" checksum="CEBBE572AFBAA18B" modified="2017-10-25" version="1">MPNIDLDSGNKISNSKGPNTKFDSIFPEKDNVIHIFTDGSKLNENNVSSVGFATWSKDTAFNSSYKILDKASIYIYTAECKALIKFIDRITDKSKCEFLIFSDSKRKMKGIFHFEQFGNIKDNKPWFNNIRLSRKAIVLINRIRCGHGEFIDNIECKILIWRRYEGNIAHVATIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBV0</accession>
    <name>A0A232FBV0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000503">
        <property type="protein sequence ID" value="OXU27960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBV0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19663" checksum="40B4AA0DB3623646" modified="2017-10-25" version="1" fragment="single">GLTKMDEKISLKKGQTFNKVFRRPIAHKFQILNPKHVKTFPNFNTNLVYTRLVDKCKFGDYVRSRGKGERATSTCRFGCKAFIKLNAFFHMLPENRLDISNVVLNDIKDKLNVRGNKKVIQSELHKQKIFLNLKDLTNIKSRMKTVNGDNLQKTVDYLIDEKNAIVEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCW8</accession>
    <name>A0A232FCW8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_003386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000453">
        <property type="protein sequence ID" value="OXU28288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCW8"/>
    <dbReference type="STRING" id="543379.A0A232FCW8"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU28288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11610" checksum="E3C70ACD2E17C605" modified="2017-10-25" version="1">MGDANNGKSLFKKMCVQCHTSEQGGKSKIGPNLFGIFGKTCGSREGFKFSDHMKNKKVSWDETNMDEYLQNPKKFIPGTRMAFAGVKKPEDRKDIIAYLKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDD6</accession>
    <name>A0A232FDD6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the muscleblind family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000375">
        <property type="protein sequence ID" value="OXU28806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDD6"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF12">
        <property type="entry name" value="PROTEIN MUSCLEBLIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU28806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="79" mass="8765" checksum="14DFFF35E20783AC" modified="2017-10-25" version="1" fragment="single">QLLDTLPVCQDFNRQLCNRPACKFIHLHDGNVEVIENRVTVCRDAVKGTCMRPQCKYYHIPVALPPAPLMAVSSSASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDP6</accession>
    <name>A0A232FDP6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01000414">
        <property type="protein sequence ID" value="OXU28579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDP6"/>
    <dbReference type="SMR" id="A0A232FDP6"/>
    <dbReference type="STRING" id="543379.A0A232FDP6"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="307" mass="35000" checksum="B819A62A6B820F55" modified="2017-10-25" version="1">MADSSDLDRQIEQLKKCEIINEAEVKALCAKAREILIEESNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVPETNYLFMGDFVDRGFFSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSNTVWRHCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRIIDRKQEVPHDGPMCDLLWSDPEETQGWGVSPRGAGYLFGSDVVAQFNSANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELNEHLQRDFTIFEAAPQESRGTPSKKPQADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE12</accession>
    <name>A0A232FE12_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000384">
        <property type="protein sequence ID" value="OXU28760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE12"/>
    <dbReference type="STRING" id="543379.A0A232FE12"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="114"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34525" checksum="BF25B5EB2F24B64F" modified="2017-10-25" version="1">MDAIKKKMQGMKLEKDNAMDRALLCEQQARDANARAEKAEEEARALQKKIQTIENELDQTQEALMQVNAKLEEKDKALQNSPKKRQPVVFRVELIRHTHGTAEKMSTQVQGTLLDVLKKKMRQTKEEMEKYKDECEDYHKRLQVEVLRREEAESEVAALNRRIQLLEEDLERSEERLATATAKLAEASQAADESERIRKALENRTNMEDDRVASLEQQLAQAKLIAEEADKKYEEILENRSLADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEAGESPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE83</accession>
    <name>A0A232FE83_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000348">
        <property type="protein sequence ID" value="OXU29005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE83"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="9154" checksum="D97E43A72BB07994" modified="2017-10-25" version="1">MGKATEPRCLHCASQKDDALHTFFVCEKWRDERVGLEDDGVRLTPDDIIPHMLAHRETWDNVARCVEKILRHKWADLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF01</accession>
    <name>A0A232FF01_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_001063</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000305">
        <property type="protein sequence ID" value="OXU29334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF01"/>
    <dbReference type="STRING" id="543379.A0A232FF01"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF40">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="15">
        <location>
            <begin position="281"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU29334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="580" mass="64564" checksum="6B1C398A1C157DF7" modified="2017-10-25" version="1">MPTLPSKPGPFIGVIDVGTRTVRFVIFNAKHVTEVHSHQIDIEQLTPQEGWVEQDPKEIQSAISTCISNVLRKMEEKGLEASSIVTIGICNSRETTLVWDSKTGEPLYNAILWSDIRTDKLVDQIIARFPDNNKNHLRPICGLPVSSYFSALKIRWLMDNVPGVRKAIRERRCMFGTLDTWLVWNFTGGKDGGLYITDVTNASRTMLMNIETVTWDITLCRYFNIPMHILPKIRSSSEIYGNIKVGQLKGIPISGILGNQQAALVGQNCLKQGQAKNTYRSGCFLLCNTGTQRVFSSHGLVTTVAYQLGPNSPVVYALEGSVAVAGLAIKWLRDNMKMMKDVHESEHLAQKVFNTGDVYFVPAFSGLYAPYWRKDARGVICGLTAFSTKDHIIRASLEAVCFQTRDILEAMFKDCGFPLTKLYTDGKMSVNSLLMQLQADISGVPVFRSTVADITALGAAKAAGNAAGIGLWELEGAGVETVITDTFLPTTSPEERDARYKKWRMAVQRSLGWASEKMSPQMTGNKKHTAGSRTEHVDSIKDSLVDTSNERYRILASIPASWFLMTSFILLRLSYYFDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF23</accession>
    <name>A0A232FF23_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000302">
        <property type="protein sequence ID" value="OXU29354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FF23"/>
    <dbReference type="OrthoDB" id="7684512at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895599" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1595"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1632"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1672"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1723"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1739"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1779"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1796"/>
            <end position="1809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1890" mass="214066" checksum="85BED423F445E539" modified="2017-10-25" version="1">MRISNDRELVILLLFYWQYIGGANLENISIESVLDQVAIPTKIINVFLQKPIRNLPSKKYVANEEVESSTIHYENANGFVPLIVSTQPYELKNNRRNLIQYDAINKTKKNTPKIIKKISIFPEETRIFFTTPNTGENRRSFQIDDNQNEFELLKVNNDTPAVATYNSFIDHSRNNYKSDRSNSEINYGKALRTKDREREKRIQNYMDSYDVAKEDSRQYTRSEVDKNNKYALYQQEKSHHYSKASTASYGTQKTSPQTNYGTITSTMSNIKAFTPKVDKNEEYRFKNPIMVDEKFRRQSLPSTAFTSNHNGDKKDEFDRATLENRESESLSQIEGTSRNYDSAGFRDFSDENLDYMEEMDKPRRVQKTSKRRPYRFDSSRKLPKEHREIYDDTYDDQGRKRANKPKSRQKQKSKPIEVVNEDDPYEKEEQFESDENNRNNQQNFNDGNTWNQVAPNVEVSHSNGYEIDQIEKPKLHIVPVNILSNFDHATALDNSQGFDITNAMFTGFVHEAPLVSTATPLISSSPNYLNRNSIPSSTSTSSMSISTPVPDVIVGQSSFNNPIQAVFMPNKLQQNMLNQYMQSTVSPTLFAVTSRPEFLGSSTISPSLQQILNQVQSSIPINQHIFNAQPTQQTYANLLQPIHSNANNQIYVNTNSDQGQNFYQFKNSQSATSTSNSETNESQQQKFNVNNGQFVASASLSVGNNQHSQTRNKNANKRNNYRINNQNQNKNNNDNIQRNQQKKGQSSSNFIQPTVVPAILHTGIGLFRNQNSQLVQNPLFIANSQSNTPIFKGTNEGLDNSMKQLQYNIKNNRYQLTSISSIDNAGGASNNVNAINNLIDPIQKAQLPLLGATNVEIVNPNLNANAYAINQVPATLVTTPIPMFTTTGFIASKQAFTSTTQEPLGADRALFNPINFVPNYDLIKSQSVLNSNVVPNNQFVQQNLNLVPVVPGGNFYKHSQGAQIDLANKPKLSSDLEKYAEEMFKESLRTIYNSHKWNNDPRSPGNISLVDNSDLAKLRNELLRIKNNIRYSKIPKDVLEAHHTENKFRTSHGQGHGPRTNFNHENSRLRPRQGVVSTKSKGQEPQASTIVDYRYSIRQHHNQPDYQSDQSYNYPTFSTSLPESDHFRSSAAYRSSEGEFYDINHQRTHNLMGLLMKNKQLPPGTQGNYYSDSQAINKAFDEENQRMQSQIRWIIVLFGVSVGSCLTLENNSTATPQNSTTNLSTLNNDLQQSIKPKRQLDEFDFDSSTFDDLPSIFPAKEITSLSTFNDDEIEDISGFIPSASFKVTRSNSESLGTHGENYESLNPPAPNYHSSPQVASQATNSQANLYSNEDSEALSQVRQTETSYNNQVTTPLYIDSYVTHPKYAAAKSSAFPRENQYKVPAKVQFNSYPTLSELAPNVPVYGPIAQVSLHSIVPNNRHQVQQSASQNTGYKAPIAHNFKNIHPTTKVYAPLHAHNQQQQYDAQFQNYAHNPYDNVQYTTTPGLEISNKKLELPVIQLQTAPNYPGYIQTLETTPLIFSSETGLQYKADPGFRLSYEFAKPKSNHPNQRSGTNSPFLGVASPIQVLPVQTASSTAQFPKFKGASIGQFPSRGFKKTDSYFPKNDDDDDDVETLPKKYFKQSELEDEEETQKQEKREKILDREQHGRRKSKGHKGRSKSYADEFEETFRRKPNKLKHSHRHSKVSKASKESNERPRISASYSASKSLKKNRHRAYRDESGEPSSRPSSLSGPTRQTFKRDYRLEESDKPKEDINSKTLPQVVWQDSYGMRVNNPEDEALRSSYSKEESAVIDSYGSTRKPSTTSRQELTTKLPYKSTTLPSQNDDKLGSSTFSPHGSWKSTGINIKPISNESYSKPSGSGLKALVNPKQNYFSPLLGRGEIFRTLKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFE7</accession>
    <name>A0A232FFE7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule-associated protein Jupiter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_009300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to all microtubule populations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAP Jupiter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000292">
        <property type="protein sequence ID" value="OXU29422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFE7"/>
    <dbReference type="STRING" id="543379.A0A232FFE7"/>
    <dbReference type="OrthoDB" id="6367565at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033335">
        <property type="entry name" value="JUPITER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34930">
        <property type="entry name" value="GEO05313P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34930:SF2">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN JUPITER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17054">
        <property type="entry name" value="JUPITER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU29422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="255" mass="26385" checksum="F6DC226CB86B9614" modified="2017-10-25" version="1">MATYAAYRHVELDNVGYGKKRVLKPPGGGSSDIFGAGGEVNSPRRAKHHNQSQLGSNFFGNGESQPSSNGSSAPETPRSNKPGNDSYKRLFGPPDARPPSTPNSKNHMRSNIALSSASSTEPNSPSRNGTALSHSSSNGSMSNGSSNAHLANGNGYHQNDVVGGSSCMPRNPVTGDGVDVKPHASRRIVRRSRDGNPVTGAGYEQPLAQQNGNANGGGSSASSDKSSTDSSPSANSNVPRMKNRVPPGGFSSGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGC1</accession>
    <name>A0A232FGC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pseudouridylate synthase 1 homolog</fullName>
            <ecNumber evidence="12">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA pseudouridine synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSAR_012937</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Alberta</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. Forms a complex with RARG and the SRA1 RNA in the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01000286">
        <property type="protein sequence ID" value="OXU29479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGC1"/>
    <dbReference type="STRING" id="543379.A0A232FGC1"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="21">
        <location>
            <begin position="239"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXU29479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="432" mass="50109" checksum="A188E76C6E42CD22" modified="2017-10-25" version="1">MLRLIRTQELLSSSKYSRTLVTQASTMTENKEIETSQGEKRPLDNDADIEAKKQKIETQPFIRIKRKNYAMMLGYCGKNYYGMQRNPGFNTIEEELIKAMLKADLITSEAFETIQNINFQRAARTDKGVSAVRQVVSLKLPEDPSKESINETLPEDIRVFAIKRVTKGFNSKSQCDARTYSYTMPTFALAPENLELFQEMAEYNDIEKRMEQLSIIDGKPFHEYRLPQERKEKLTDLLKVLEGTHNFHNFTSKVLPLDPRAKRYIMSFIAEEPFVVNNMEFITLKVKGQSFMLHQIRKMVAMVIGVIRNIVPREEFEKTVFEQAKYDITIAPSLGLMLNIVHYDYYNKRYGSDGMHDTLDWAECDQEIAEFEKNFILKHVFDTELKEKPMLEWLATLQVGAYGVRDESRDQKDDAKEDKDAKDDAKSSVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH88</accession>
    <name>A0A232FH88_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 179</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000193">
        <property type="protein sequence ID" value="OXU30111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH88"/>
    <dbReference type="OrthoDB" id="6423876at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029673">
        <property type="entry name" value="TMEM179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25055" checksum="0A76D28232158EC9" modified="2017-10-25" version="1">MAFTNVLLLSQIAGYVVALILSLCIIVPMSLHQDEFRGHCLLFSTGNWRESDGQFVPDWASQMYCNYTIFVGLILFLTAAVQIYRLSMLMYKGEDSSFLSAFVDVITSVFLTSITLIAAVIITLGFMTWCQCMTKRFPSCELAAGNDIDKADNIDTSGFHIELGAAQFGTWSSLSIWVGLSVFATLKLLRYHQLENMKVSMYRERQRLIEAASSGSGSNKHPEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI79</accession>
    <name>A0A232FI79_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Icarapin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000165">
        <property type="protein sequence ID" value="OXU30382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI79"/>
    <dbReference type="OrthoDB" id="6346805at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23204" checksum="BE598EAC37BF3D69" modified="2017-10-25" version="1">MNLSTGANRESAESSESDDKTDGVVLVLPRHNIFDDLGDDDESSMGMPGMWHPFRFDNSPFDGLFTRMQEAMNRVRAEMAAALASQLGQVGGLTPWGKIPEGANTTSTTKVIGDHQVTINETTYSDGDENSGTIFRVRVVDVKPLNETTDATEPETSSEEADAKPTKRPDDSPAEKQNEDREELTTPAPRSVESLEEFDNEIPKNQVDVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIC8</accession>
    <name>A0A232FIC8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000184">
        <property type="protein sequence ID" value="OXU30209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIC8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263231" evidence="1">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="17071" checksum="7F400BDF7701E156" modified="2017-10-25" version="1">MKFTVNWLLLPMVLNLCTCGGRTECVKRSKLAVIANLQTKRCENNVNDFFYTQDADNNLSHKYNFDYKGLTIDSAILPVLRTTLLQLIGNVATHQNVCFLIARLVISHTDPNILKTLPEDCIHSYRNIARNLINISARCKTLLLDYTVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIJ0</accession>
    <name>A0A232FIJ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000155">
        <property type="protein sequence ID" value="OXU30492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIJ0"/>
    <dbReference type="SMR" id="A0A232FIJ0"/>
    <dbReference type="STRING" id="543379.A0A232FIJ0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23733" checksum="B2FE3A43A5CE24DC" modified="2017-10-25" version="1">MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDVTNEKSFENIKNWIRNIEENASADVEKMLLGNKCELTSKRQVSKERGEALAIEYGIKFMETSAKSSINVEEAFFTLARDIKAKMEKRLEASNPPKGGGHQLKAMEPQRKPPSLFSRCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIN2</accession>
    <name>A0A232FIN2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000159">
        <property type="protein sequence ID" value="OXU30443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIN2"/>
    <dbReference type="OrthoDB" id="8192147at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="338" mass="37132" checksum="7159739A9D35CE0B" modified="2017-10-25" version="1">MGSSRPTDRSIGEATFLPQWMKGKLDTRFDYTESTFSPPADDTFFYIRYPKSSSQDASANSNAGNKEGFRPLSEIIGGVGSSKPEATASSGKLLAGTSGTEYKDAKNIDFSKHPLPCQAFIPFTADKANEPKIIIANKPKVKHLPADDEFRNDNAAECGRSIVNVANQIMSSKFGKSNSSDASSATQHQVDDAAAQQMKVSRSLPATPLASPSGTPDSSPKTRRRAYGNRFFTPAFIPDSSGEYQQQQSQRYKNGWLLSSILGQSRELIAPKIEEEDEQLGQEPIPSRALSRKKSISSQNLTYLGKEDKKQETTKSHILMQAKPSELREMNFWSPTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIV7</accession>
    <name>A0A232FIV7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000164">
        <property type="protein sequence ID" value="OXU30399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIV7"/>
    <dbReference type="STRING" id="543379.A0A232FIV7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="99" mass="11619" checksum="51DE9B07DC393E57" modified="2017-10-25" version="1">MRRMRHQLRELEEKVKRLEKPQASQRRSLFTGAEQRRTPRAKSQQKTASASSTLQKSKTNPRKRPKGQSKKDTRKSVPPSNVLRFVERVERKGERKPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ27</accession>
    <name>A0A232FJ27_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_015423</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000174">
        <property type="protein sequence ID" value="OXU30307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ27"/>
    <dbReference type="STRING" id="543379.A0A232FJ27"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000035">
        <property type="entry name" value="Kinesin-like protein KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="13"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="359"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="985"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU30307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1104" mass="125724" checksum="12CBF7AF08C0BFB0" modified="2017-10-25" version="1">MNDTRSKKDKNQHIQVFVRVRPANNAEKTSKSPVVVDVPSNKDIVVRERPQDKLTKKFTFDKVFGPLSKQIDVYNAVVSPLLEEVLAGYNCTVFAYGQTGTGKTFTMEGACNDPTLHWQADSPAGIIPRALSHLFDELRTLGAQEYSVRVSFLELYNEELFDLLSPNDDASKIRIYEDASRKGAIIIHGLEEVTVHNKSEVYKILEKGSEKRQTAATLMNAHSSRSHTVFSITVHIKENTVDGEELLKTGKLNLVDLAGSENVGRSGAVDRRAREAGNINQSLLTLGRVITALVERAPHIPYRESKLTRLLQESLGGRTKTSIIATISPANMNIEETLSTLDYAHRAKNITNRPEINQKLSKKALLKEYTEEIERLRRDLLATRERNGVYLAQESYNDMQSTIEVQSKEIEEKINHIKALEETMQNKEKLFCDLKMEFETTTNALHQTKEKLESTHNVLMTTKNQLNETVYDRDLHKHLVDKHVSTERTLLNQAKTLLSVAETATTDTQKLHEKINRKKKVEEENESLGQQFRQEMLHRFQHVEEHVGNYTQELDNFCSALKDQISSAATHQSTGIDTAIKHISNDLVNKEIAISENLTENTNNTHDEYNSWILTQIEKASDMSERERQALQSTLSKISPKIRELVETKISESLKSLHNETSLKLINLTNTMKKSVDEFCSTLLVDRDNLIKQIDEVKKAVDVSVKNKNRIMEIEQSFDKMFADMKSQIVNTLENTWKQYENDKTEKQQSYSIISNKLNEIDVAINSSNEQTINNFNNKVQQQKAIETRIEKNVEDIRNEVSSTLEENWNLADKAITQSVDVVNLLEGDINATRYALLSYNNSVEANAMELRHKNEKQKEAILSKVQEYHKMVTDISTTHSHFMEEHRAAAHNNYSEMNYKLESQSVACTEWDSKIKSQLHSIHEKVDKFVAEDLRHDVPTGTTPARRDFNYPRHLAATSPHERIIKRFREVRKVVESSEDESENTITDMMSPNVNGRDNNSLSSPIITNTNHVTSTPYSDSKLRIPVIRNSYSLIKSASTSDLPLATKAQLDSSTMSESEVVKGRNNKENGEEGFIKPEKLRPKRLSKVKNAQNRKILGSCYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJH7</accession>
    <name>A0A232FJH7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000109">
        <property type="protein sequence ID" value="OXU30894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJH7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="26" mass="2924" checksum="960809252341B0FD" modified="2017-10-25" version="1">MCPRERHPPLDSLAWQSQIGPLASPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJP1</accession>
    <name>A0A232FJP1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_002789</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000103">
        <property type="protein sequence ID" value="OXU30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJP1"/>
    <dbReference type="SMR" id="A0A232FJP1"/>
    <dbReference type="STRING" id="543379.A0A232FJP1"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000001">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="13">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="13122" checksum="246FB7B05DA30CC2" modified="2017-10-25" version="1">METVPKDLRGLRACLVCSLIKTFDQFEFDGCENCDEFLRMKNNKDNVFDCTSSNFDGMIAAMSPEDSWVCKWQRISRFTKGVYAISVSGRVPANIIREMKSRGITYRSRDTSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK07</accession>
    <name>A0A232FK07_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000090">
        <property type="protein sequence ID" value="OXU31076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK07"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082232" evidence="2">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="154" mass="17845" checksum="67BB9A2714915EEF" modified="2017-10-25" version="1">MFSRVLIFVLLGCALAFVQSSSAAEVQSKLRVRREPHGEKVAAWWHNLEDKVSKFAQNVKDKITNWWDKITGRAAYKAKQQELLKLKQEYEALKEESERAVRAKKEAWQKVLAENEKRLAELRDQAESEVEGEINGWDSKFDQLQEKAEVVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKS7</accession>
    <name>A0A232FKS7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000073">
        <property type="protein sequence ID" value="OXU31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKS7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23406" checksum="318053D2A9EE84AC" modified="2017-10-25" version="1">MKELKRLEGTAEAELKRFKDELDAEAERKCKKGLKSEVKYELGQENTVEDISKVAIEIENYIKKETDIYNGIVNNVYEDYEREVEQTQKVLACQILQNCPNVVCKRCNKKGHTIKYCKAGEGKSNFRICAICETVQNTKLNSSLSGRYAKKPVTQQNSARDLNINSKQVVIITTEVFRRNFANTENLQVMYSIQINHLADIESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM84</accession>
    <name>A0A232FM84_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_016120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000041">
        <property type="protein sequence ID" value="OXU31630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM84"/>
    <dbReference type="STRING" id="543379.A0A232FM84"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU31630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19027" checksum="50B622A2B2335F56" modified="2017-10-25" version="1">MKKSSAINEKLCQGKDVFERMNFLYQASFLLSSKNKALASYYGSIMTSCAKKAVLRVDHNLKRTVCRACQSPLIPGKTAKVRLMPKNKLIKTVCLICKTKKQIPYKGKHKLWFDQSEALLETFEYKLKKKTTNVEKNVSNGESKDSDAPESAKKQKLNDGNNATDNKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMT1</accession>
    <name>A0A232FMT1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000013">
        <property type="protein sequence ID" value="OXU31982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMT1"/>
    <dbReference type="STRING" id="543379.A0A232FMT1"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU31982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8948" checksum="AB98B69AA24D20D9" modified="2017-10-25" version="1">MELKNIHVSFLRTVPPYSHQADVWVELLRYFNYMKVIFIHSSDTDGRSLLGRFQSTSQILEDDMEVKIQLYEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMZ1</accession>
    <name>A0A232FMZ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystrophin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000019">
        <property type="protein sequence ID" value="OXU31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMZ1"/>
    <dbReference type="STRING" id="543379.A0A232FMZ1"/>
    <dbReference type="OrthoDB" id="10057795at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32690" checksum="F3564A303183C797" modified="2017-10-25" version="1">MLLGYLITVDYGGRKYSSASGYTWPGRRCWRRRSRFELPRRWEDARFVYLSYTLIAELRYFEEDLQSEIETHHDVYASLNGTGRKLLSSLASQDDAVMLQRRLDEMNQRWHHLKAKSMAIRNRLESNTEHWNALLLSLRELIEWVIRKDTELTGLGPVCGDIAALQKQQDDHRGFRRQLEDKRPIVENSLLSGRQYIANEPPLSDTSDSEGRDLDGDSRGYRSAEEQARELTRSIRREVNKLSEQWNALIERSDAWKRKLDDTASVSTTNYHFYFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNB1</accession>
    <name>A0A232FNB1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNB1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="11859" checksum="CD702187328A65DE" modified="2017-10-25" version="1">MVETKVVEYRRGNPMVTLDLTLNAFFKICDLSWFACGPWLVGKLKATGPGRESSNGTEALSCPSKALRLHPGVKVVDWILMIAKRYVVPLHLAHPVCVSGSRLHGCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNV3</accession>
    <name>A0A232FNV3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNV3"/>
    <dbReference type="STRING" id="543379.A0A232FNV3"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU32138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="460" mass="54326" checksum="C201CF68529BA261" modified="2017-10-25" version="1">MLESGSSLKSWPLYLQQQVLMQQKEDLANSIAYKVHPNERKCYECLTCQRRFSQKTTITRHLRYFCGKGHRYKCPYCDALASCSSNIYRHVRSRHDGKMPHAIKLFTSITDRLIGQRSRRHVYSIKKSYYCPRCNHGYTEKANMIRHFRHECGVPPKYQCPYCTYPSKYTHNIYAHFTDSSFSKDQPPTVTLEALNQSYWKPMPQQQVPLVRYYYCPCCNHRYTNKANMLKHYRHVCGRPPQYKCPHCEYISRYAHNVYAHVRRVHPSEKPSFTHKTHLTRITPRYKHDWLLLLLLTDPLRLVPRYTLETPGSIYRARGKFRCDICGKSYKWYSGLYRHKTYECGKLPRFQCPHCEYVAKQRPHVYSHIKSAHKNSAIYALDLEISEGLASTIISNGGTWDIASTVYQTPTVGNINDVGPLRFACPYCQFRNKRKDHIYRHIRGKHPSQAVCYIDLYLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FP31</accession>
    <name>A0A232FP31_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FP31"/>
    <dbReference type="OrthoDB" id="10460776at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12938" checksum="13E15CFE0F7E8914" modified="2017-10-25" version="1">MVYLHKPRIFYLELAVLIWGERNLSNRALDLTRTVKNIPNRSPVKLIEKDILRLLISLYNDFLNNHKYPSDEKASYLLRAFYVLRHKITDLSSTKKRNFSNQMSTLKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED09</accession>
    <name>A0A232ED09_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01009982">
        <property type="protein sequence ID" value="OXU16228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED09"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="413" mass="47673" checksum="2C111953E451EA1E" modified="2017-10-25" version="1">MLSRARKKCPVSVEHFAAHRGGQLVWASGVREHVRCRTMLLLGPTDDCLDCSRQFQVNRRKGKMSVKSAILKQLEERYVLLSSRMERASRLIQQLRDTYAELYEEREELKSALRDLENSPSVGPVNSYKPRLGDVARESQRLCFLALVKSVPCPSSISPHIAAASLFGHRVYENTLLGPTDDCLDCSRQFQVNRRKGKMSVKSAILKQLEERYVLLSSRMERASRLIQQLRDTYAELYEEREELKSALRDLENSPSVGPVNSYKPRLGDVCEMCARIMRRMTKRTQWSFCTECRSRRCTTCSRKELLCCSLQVVRRNEMAEAVIEEKMPQQQQQPKEVHADQDYLKKEKEEDDEDDEEEEEAKKMQDDSTSDTDIDVGEEFFTGYFTSNDKFSCKKWIADGCLPKNKTVNDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDH4</accession>
    <name>A0A232EDH4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006513">
        <property type="protein sequence ID" value="OXU16382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDH4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263214" evidence="2">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="7844" checksum="35C4BE3C65C3E3FD" modified="2017-10-25" version="1">MSPSSRRMAVKWLGIITITFWLGGTQTADQAERPRSVLVSSSSESGECPQRSHPSDLRGKTLVSLMRPEGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDY8</accession>
    <name>A0A232EDY8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005792">
        <property type="protein sequence ID" value="OXU16565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="35" mass="3971" checksum="B70DC2858DAC3746" modified="2017-10-25" version="1">MCAEFAKICLAGQPAFSEQRLLCTQEPDFFXYEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEJ4</accession>
    <name>A0A232EEJ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005312">
        <property type="protein sequence ID" value="OXU16767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEJ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="272" mass="30228" checksum="B7132BA4B39C5462" modified="2017-10-25" version="1">MTNLEETVEQDAAEKSKEIVELRRDITVYIRETDDRAALEDMAESSVSGIARSLGSNIRQAIGRMLAYVGMASQTAFIVGMREWPKRTITGENHAAEPVKHITADSIVRFCSTAVRNTVLSSAYLLDKLSLKDILGCPGSGKIYMSPLYPKYVYLLNKKTRKVTKNLSYALPIRQKYGELSSTPRQNHAECAQIYCHCFPNRLKQALATVQADAQAMSDWATENILSLNLAKCKVMILGSQAYISRIDTNNLQKITVNNVPLFVTEACNLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEJ5</accession>
    <name>A0A232EEJ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005318">
        <property type="protein sequence ID" value="OXU16763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEJ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="4">
        <location>
            <begin position="102"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU16763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="302" mass="35014" checksum="2D714ECA3563545C" modified="2017-10-25" version="1">MQSSMNLKKFCNNLINHENYYFLSKSSRATVARYTMRDLEFSTLRQGIWINGIVINSFVATHIDEWIDFTYVPSDDSITIAGDHSHERVNRNKYISRTTKRMKNNLLLPYLYCSHWRLLHVQRKIMLLDPYGTDPDQDRAVKAFKNFTEFCTPDSSVSKLKNIQRVTEEVINRPYQPHDDGHSCGSYVMYYLLCIGSGKSFDMNFNPSTFRNELAYRLLLKSDNMESICLNCSATTLNEAYLKCILCKRKCREACIFKAQIDTDDEEKILKNKLVKRDDVNYDVGSKLIDSIGVNTIHLASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF59</accession>
    <name>A0A232EF59_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005122">
        <property type="protein sequence ID" value="OXU16973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF59"/>
    <dbReference type="STRING" id="543379.A0A232EF59"/>
    <dbReference type="OrthoDB" id="7635422at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759813" evidence="2">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="307" mass="34266" checksum="9C19D82D7F35108D" modified="2017-10-25" version="1">MKNLKFQLIFGLVMCCGQALAAEPENQNNQQRKRGILNDGWVGLHNPYGHYGLGQPWSGVDNNPWKGLKINPVLPLDTAGWQYGGIKATVGWPIKHETHHVKTVPVVVTKHVVVEKPVAVRVPEPVLVDRPVPVEKLIPVPIEKIIHKPVPIAVPYPQAYPVPVEHAVPIPVKHPVAVPVHQPYPVPIKHPVPYPVAVPIPFPVHHHGHHHGFHFGHGHGYGGHGYSHHHGHGGFPYVQLPYHSYHGYGYPGYYGHGHGWYGDHSHGHGHYYGGPEHRHSHRSADYNKSKRSKSSSSKESLKDEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFJ3</accession>
    <name>A0A232EFJ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004984">
        <property type="protein sequence ID" value="OXU17139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFJ3"/>
    <dbReference type="OrthoDB" id="6162705at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="227" mass="25169" checksum="E696914B62EEF25D" modified="2017-10-25" version="1">MALKVLEVRNKEVKINGMATDVEESDTDEQEKPGPAKRQRLQSVTAVEASQQAPQEPVDPAEVIDEEEDRRAREKLRGWQACQVAKGFVDNTINRVLENYITSPPASYPFEDLWYRLFRGNQMEDTAITMAIRNHGLGRSLDLAQSPSLLAERVSNVPQNSENTQAPVATTSSEALLLTDSEAASNSGEGDWLDDTYDSDHQQDFLDRAVAEAIKKKGLSTLSVDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFS0</accession>
    <name>A0A232EFS0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004952">
        <property type="protein sequence ID" value="OXU17193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFS0"/>
    <dbReference type="STRING" id="543379.A0A232EFS0"/>
    <dbReference type="OrthoDB" id="7696036at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16730" checksum="BDD831EFDF870386" modified="2017-10-25" version="1">MLSIRKSINKRMAKEMGHTSTKGCTTYEFFNSVKERISKDWLKPDHFTTQFLSGHGSFKSYLFERGLSEDPDCKCGAEQSNKHILFECTEVDEIRRPLKQKVMSAGHAWPCELSVMVLDEGLFRELGAFARKYLEKEQSDPTEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFU5</accession>
    <name>A0A232EFU5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004956">
        <property type="protein sequence ID" value="OXU17182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFU5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8185" checksum="380535135F2D5E54" modified="2017-10-25" version="1">MCIPRIKVSEESINLRTGKLTMVAWAKCCLGLKIVKNHKDSQFLPSGAQIKALFFYFSLVEMTIRTGHLLGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGA7</accession>
    <name>A0A232EGA7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004836">
        <property type="protein sequence ID" value="OXU17358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGA7"/>
    <dbReference type="STRING" id="543379.A0A232EGA7"/>
    <dbReference type="OrthoDB" id="6432478at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8315" checksum="53D94B76158CEDF7" modified="2017-10-25" version="1" fragment="single">FWIIAYLHELQVRQKWLNSTATLTVGTIGIYREDNAACARWPLGLVVKVHYGSDSIARVASIKIASGLFKRNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHA7</accession>
    <name>A0A232EHA7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004531">
        <property type="protein sequence ID" value="OXU17757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHA7"/>
    <dbReference type="OrthoDB" id="7545861at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032135">
        <property type="entry name" value="DUF4817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16087">
        <property type="entry name" value="DUF4817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4817" evidence="2">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="13917" checksum="353D1E66BBFADCE2" modified="2017-10-25" version="1">MADYSPNEIVDMIIVLGECHNNYNAAAKLYAERFPDSRHPTNITIHKLVDDSLLAKADAVSTTKMMHVLLPFLQLFLFCYFCTTREDMQDRIRQACAAILRQITEHRTTFSTLFNFVPTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIB3</accession>
    <name>A0A232EIB3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004312">
        <property type="protein sequence ID" value="OXU18061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIB3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="10889" checksum="AC5BAF1A7AE9C521" modified="2017-10-25" version="1">MGCPIFLPWCIYYLSSHQNRKCKCLSRCPGRKLYYSIHVRKVSDPRTVTRVFFSGAIFAGFPIVFSAKFPAFFSADFGVGLFIDKFSLKSQNFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIJ5</accession>
    <name>A0A232EIJ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004225">
        <property type="protein sequence ID" value="OXU18173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EIJ5"/>
    <dbReference type="OrthoDB" id="7994850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="605"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="806"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116228" checksum="B12C14C5293A3B12" modified="2017-10-25" version="1" fragment="single">MFKFSTATTTDSTSVSAAASAPTSHVAAVEKIKLPTFDGKHSEWDSFKGKFTALIISDTQMAPVLKLQRLHNCLEGEALSVIRGIKSSADTFDAAWNTLLRQYDNKQVRFSKQMELLINLPVAQEESVQCLNLALKCLNSLRPQPPIQPALAQLPGTLSSDHSAPTSHVAALEKIKLPTFDGKHSEWDSFKGKFTALIISDTQMAPVLKLQRLYNCLEGEALSIIRGIKSSADTFDAAWNKLLRQYDNKQVRFSKQMELLINLPVVQEESVQCLNLALVTIDESTNVFTSLERPVKHWDDIFIYCVVSKLPPSLRLSWARIISRNHNGGFPKLKDFRKFLVERIETLLINLPVVQEESVQCLNLALVTIDESTNVFTSLERPVKHWDDIFIHCVVSKLPPLLRLSWARLISRNHNGGFPKLKDFRKFLEERIETLIAARAETDCESHDAHETNVQAQKSSNSAGKSSRGQWFKKSKGDKGVAVHAAHSRDNKNGSRSNKFALCTPEQRNAHVSAAGLCFNCLNAHHSAEKCTSKGRCLVCGGKHHTKLHSTSSRNNARTDSSSTTLTAHAAVDEASTLVATSKRCKILATACVILQSASGQSITVRALLDSGAEESLFSTRIAEALDLQKQPVRVTVSGVGGTTTAVANTSVSLKLKSPHDANFELDFSALVLPKVSTVIPRQEVRLPAWTAFESLQLADPHFXTQEQRKAHVSAAGLCFNCLNAHHSAEKCTSKRRCLVCGGKHHNKLHSSPPGNNERADSSSTTLTAHAAVDEASNLVATSKRCKILATASVILQSVSGYSINVRALLDSGADESFISTRIAEALDLQKQPVRVTVSGVDGTTTAVANTRVSLKVKSPHDSNFELDFSALALPKVSTVVLQQEVRLPALTAFKSLQLADPQIYAATFRTGFLPGPPGLRVVALNTVFGWIIKRGMGVDIAEGGDCATSLRVMTHENLSRVVTRFWKLGEVPCSSNFSPQEEAAYQLFKKTHTRNEEGRFVARLPFKRRPQISDMRAGMQVGKWAAYHEDLIRGLSAPGVDCKNTIIQEQEAVSALGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIN3</accession>
    <name>A0A232EIN3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004201">
        <property type="protein sequence ID" value="OXU18205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIN3"/>
    <dbReference type="STRING" id="543379.A0A232EIN3"/>
    <dbReference type="OrthoDB" id="6596655at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="243" mass="26724" checksum="1B6E46300256D1F4" modified="2017-10-25" version="1">MQQPVIPPEEELIRLLKFGTSRKIRDLISANPTMDLHYPLAKNLTTPLTAAVERSDSAILTTLIDKIPGNLDATLTQPCGKTALMHAACYARNSEVLLVLVKKGADPSKTDINGWNCLFYAVIGKRLQNVIALLDSQVSIESRDLQGRTPLMISAVYLSDLDMFHCLLSRGADVEALDNNGLSALHLAILRKRRECVIELSQRNAAADLLTPVSRATTQQLVEEIMSDVLPVHGKVQDFAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJX8</accession>
    <name>A0A232EJX8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003907">
        <property type="protein sequence ID" value="OXU18674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJX8"/>
    <dbReference type="STRING" id="543379.A0A232EJX8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="277" mass="31361" checksum="45A75175D5D62767" modified="2017-10-25" version="1">MKIVASQINMKNQKCSCKAAKLSSWDEVAKGTNWDQSRRCDELAIVGNFLIPEEPSQKKRKPSRLKDINKLKVPLFPEIPMTDLTIFEEVLGKVSFGTFSENVLKESQFHIIMELVNGHTLQDVIFKQNIRNKYNLTLEEKYIIALKMCKAIIFLHQHPLKVLHRDIEPGNVMLTLKDKDVKVCDLGLAKFNEINSQLRSTIGCSTPESPLFMAPEVYLLKQTTSQFTDVRALAATITELSSGHPLWKCNGGRARFNLTNLMMNGEMPSLLDVPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENY3</accession>
    <name>A0A232ENY3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003043">
        <property type="protein sequence ID" value="OXU20064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENY3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="11883" checksum="621779BA3D52BB05" modified="2017-10-25" version="1">MGREEEPTASPCTTLLVKSRCVEVSWAGEQDWLSVVGEAVGWSLTVSVQAGDWSAKSTAARRQELCLLQSKKVKSVARSRLSAGQVLHVDVLHQQPYHAVVARQQRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPG3</accession>
    <name>A0A232EPG3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002956">
        <property type="protein sequence ID" value="OXU20217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPG3"/>
    <dbReference type="STRING" id="543379.A0A232EPG3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="196"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40521" checksum="188A42D083920FAF" modified="2017-10-25" version="1">MEPMNKTSLKNFVHKSGRTTAQFNEFKYTWVLENFLYFKARKCGVCTTSPTFTVYNNQHKYEWLLKLFPNGNDEQTKGLMGVHLERVSSPAESKETIIIKLTLLSTDGKQVTVADKPRGIICPEKNIVLTFNKSWDDLRQRFIFANGELTISCSMVFDNGDHHVEVDSETISISEFDCQELLIDDLEAMLTSPRFSDVKLLVTGKEFQAHKVILAARSPVFLAMLESNMKEGQDSVIEVGDIEPDVMAELLRFIYTGKVENMDELVADLLAAADMYQLDHLRIMCEAIIAKKLSIDNVAEILKIVDRHVTCKNLRESVFKFLACNGKDVAGLKKFDEILRSLSTTLVIEVTKAVMLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPK1</accession>
    <name>A0A232EPK1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 28A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002928">
        <property type="protein sequence ID" value="OXU20284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPK1"/>
    <dbReference type="STRING" id="543379.A0A232EPK1"/>
    <dbReference type="OrthoDB" id="9977011at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400">
        <property type="entry name" value="CHEMOKINE C-C MOTIF RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 28A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25356" checksum="3E100FE021A2CB07" modified="2017-10-25" version="1">MNNNENSTCGELQQLVQQEEESEEPSSRGVDATPPSTPTKSNRPSKTEMHTSHALQQVMWESNAQASSVISKGSSSQATTSQGSTSGKAAANSSSYTTGQQSRLIYLNEKKTTRPEIPRVNKQPKEVPDVRHMEQALLQLLEDFHSGNLLDAGSLPFCENAGKDCSMEQMTEIREQQEKLARLHFEMGQRQDIHGTEQSGFRQSSANMHNLLQRLEQLSVCIEKLHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQL2</accession>
    <name>A0A232EQL2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_014391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002745">
        <property type="protein sequence ID" value="OXU20640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQL2"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6817" checksum="861B826DB46D788D" modified="2017-10-25" version="1">MSLSPQTKQKISVVLNVSKTVFHWGFIPAVLYLAYFGNKKFDSNLTMKKIEGFPARLQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQQ7</accession>
    <name>A0A232EQQ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002740">
        <property type="protein sequence ID" value="OXU20657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQQ7"/>
    <dbReference type="STRING" id="543379.A0A232EQQ7"/>
    <dbReference type="OrthoDB" id="10051896at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375825" description="Peptidase S1 domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="41"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="273" mass="30049" checksum="011CEA89776B365A" modified="2017-10-25" version="1">MKTLIASLIVINYIQMSVATWHSPLDPMFLDDKGVDPTLRIIGGNDAGIHEVPYTVSLRVFDRHFCGGSIISRNWIVSAAHCFLPVVPIALVRIRSGSSFSNFAGTMHSVSRVYSHENFTLTNRGSTIHDIAVVRVSPSFQLNKSTRRPIGMFEPGQKAPDNAVGVLSGWGVLHETDNKMSYVLQKVEIPLVPKSKCRELLRKYGGLAKGQFCAGFMSGGKDACQGDSGGPFVVGRKLYGLVSWGKGCARRYLPGAYTEISFYRQWIKKYTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER73</accession>
    <name>A0A232ER73_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002667">
        <property type="protein sequence ID" value="OXU20817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER73"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="208" mass="23722" checksum="E8CC8F508E1ABA39" modified="2017-10-25" version="1">MAHGGNNIRMFSEKNNELFAKEAGDNMHCAELINPPDTVEHQKQEEVSSDDTSNILINEVEAIEESDCNAHSSMNSTSKEIFNILTCAPIPDSSSKTVHERNFDFEKCSNFKDYEEETDKSSDVENSGTFFEQNYVNVKTLPYENIQEENEDYNYNKNGLSDTNVSNHIDIEHNSYENVAISPQNDQTTSLVEIEHQQITKKEPSYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERU4</accession>
    <name>A0A232ERU4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002548">
        <property type="protein sequence ID" value="OXU21083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERU4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12907" checksum="3A3F161A33331EA7" modified="2017-10-25" version="1">MYREFLVFVICTYAVHIEAHIKTIDGPTGCSQYDCKYLCTYFLSIYIWRDNHDQIVNYVDQSKDVCKDIYSFTCNATDEGIFSEESMRSQYVMKLIERAECNVLIIPCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES16</accession>
    <name>A0A232ES16_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002521">
        <property type="protein sequence ID" value="OXU21145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES16"/>
    <dbReference type="STRING" id="543379.A0A232ES16"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18397" checksum="C46D9AB5D9E069BE" modified="2017-10-25" version="1">MHAIAEAAAPRKYAKNEGPEKAASSVPPRLIKRVPNANYGLAKISHWALDNGLVINATKTQAMWVSSRGFISRIILDDTVITPCSSLKILGVVIDSTLSWREQCNIMARKCFAALSRLRKCRSYLTKDTRFLLIKTLIFPYLDYWASAFLDLLKKLILQLVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES26</accession>
    <name>A0A232ES26_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002546">
        <property type="protein sequence ID" value="OXU21086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES26"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013031374" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="8381" checksum="6C9B39F05A5E5D0B" modified="2017-10-25" version="1">MKFLLCSFLFALVLVGSLGDPLNVYTQATPAASIPTPPPGKTMKDVRAENLAKLCQEKCNKDDQGERVKQFCKDFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESQ1</accession>
    <name>A0A232ESQ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002393">
        <property type="protein sequence ID" value="OXU21372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESQ1"/>
    <dbReference type="STRING" id="543379.A0A232ESQ1"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="584" mass="66682" checksum="1941A0BF32D618D7" modified="2017-10-25" version="1">MAPNILKSSLENASFNIIFQIMCRFVTFFLNAFVVRHVGQNILGVMNVRLLLLESMILFLSKEPFMKACLTNTAEHNWAQVVNLLWMTVPICVAMSSIFGYIWLFVLQAPEALPPFYTFAVCAVAISCIIELSSLVVQLVASAFLFVRLRLYSKMNCLLVEEGCLFLSNKIYRFFKSYLTDLTTTFVLFVIYNPDNALLAFGVAQLVAAIFYTISHYAYFHYYIKRVKRHKLKRRLSMSDDGTEEYVESEFPFMSIKDFLPGQLENHASNPLYKSCSDTLLDEKLSTLTISFFKQGILKQVLTEGERLIMTILPVLTFAEQGVYEVVNNLGSLAARFIFRPIEESGYFYFTQMVQRDRPISRQNPANIQESTNVLRYLCSLVTSIGLIVLVFGQSYSSLLLWLYGGEKLIADLPVLLLRAHCLAVLLLGVNGVTECYTNATADSTTINKNNLMMIYQSIAFLVTSYIFATWFGSVGFIFGNCVNMILRIYHSVTFINKRYSETNYQPLLGLVPKPFFSSSLVVAALVTTCSHTYYFPDDKFLHLFIGVIVFGVVAFSWIYENYDLLKLGLNKWFERRNRDDKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET22</accession>
    <name>A0A232ET22_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">FYVE, RhoGEF and PH domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002344">
        <property type="protein sequence ID" value="OXU21504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET22"/>
    <dbReference type="STRING" id="543379.A0A232ET22"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13388">
        <property type="entry name" value="PH1_FGD1-4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF241">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="213"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="430"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="549"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="637"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="86345" checksum="4A39D82502E33201" modified="2017-10-25" version="1">MLRGQLKDFTSWMACLRPEPFEPKMFGSKTSGTSTFYTDLHITDDKDSQPASGESEKTGNRNSRLLEQQSAASEDGNSQDSDSVGGQEEQNQYPRHSFHRIASFGGFPRFRPFVMSTASAVCTEVNTTQETTIESSYTNMSHSVLEYRSSRYVVQESSYQNDYAVSESESDEESEETRSSETDSAIVADHVDDLLADQRLRARKSSIEAKRKKARHIADELLTTEKKYVNILYLIDQIFQFRVDQENRAHPMFPPDTVQQMFSNIKSIYKFHNDFLLPQLETRIEAWDADPRIGDIMKNFAPFLKMYTEYVKNFDYAINLISTLQQKVPRFAAIINEIQKLDECAKLSLAHHMLSPIQRLPRYELLLKDYLRNLVKDNPDYEDTKKALELVSTAANHTNEAMKKIDKFKKLLEIQESIYDSTDLVSATRELVKEGRIVKISARSGDHQERHMFLFSDILLLCSLRLIPGPLYRLRAKFAIESLQVIEGDNLETANTFYLRGRNKSVELYTHSATEKAAWLDALFETMQEIMRRKASLKIGNANTALLKADDVTRCMVCEVIFSVMKRKHNCRACGIVVCSKCSNQKLLFEDNKNMRVCRLCHAALTQPMSKSTSPSSPTTGSNGPVPSLLQVSAAAASVLSGYLLLKTQASKPWTRRWFALHNDFVLYTFKTESERTAMTATPMPGFTVTEGTDLPDEDALNAKDRVRAFKIHHSRKSYYLQASSQTDKERWLNALQLATKAELPQATDEVKDAQPESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETB1</accession>
    <name>A0A232ETB1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002295">
        <property type="protein sequence ID" value="OXU21598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETB1"/>
    <dbReference type="STRING" id="543379.A0A232ETB1"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061177">
        <property type="term" value="C:type Is terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900073">
        <property type="term" value="P:regulation of neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000017">
        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="19040" checksum="D4E5CBA681CB5CDB" modified="2017-10-25" version="1">MKKSLVSMNTPKQITKLRIFHRTSGDSLYAILEIPKTATPDDIKKTYRKLALKYHPDKNPNNPEAAEKFKEINRARIILTDLTKRNIYDNYGSLGLYVAEQFGEENVNAYFVITSKWTKMFFLFCGIITGCYCCCCFCCCCNFCCGKCKPTPPEDSGAYHNLQLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETP4</accession>
    <name>A0A232ETP4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002271">
        <property type="protein sequence ID" value="OXU21666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETP4"/>
    <dbReference type="STRING" id="543379.A0A232ETP4"/>
    <dbReference type="OrthoDB" id="6371642at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144665" evidence="2">
        <location>
            <begin position="21"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin N-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin middle" evidence="3">
        <location>
            <begin position="161"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="5">
        <location>
            <begin position="450"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU21666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="698" mass="83730" checksum="A57D1FD8A7155C54" modified="2017-10-25" version="1">MMRNCIVFALLVAMAAASQSYPGFYSKTADMEFLHKQKKIFDLLMYVDQNVLTDTEYFEFGRNFDIAANVDYFTNKEAVYDFLGYFKSGFLAKDALFTYYKQEHREEMMLLYRLFYFAKDFTTFYKTACWARIHINPGMFTAAFTTAVIYREDTKYIRLPAIYEIYPNLFFDAKVIRDAHRLKMTRGYGYHGYDHRMPFAKGSFENVESFYVYSNYTDVCINPTNALEYKLNYFTEDVGLNAFYYYFRMSFPFWMDSKDYDVPKSFRGDLYYFFHKQIMSRYYLERFSNELGEIEDFSWDSMSLPGFYSDVSFFNGVSMPRRDWWNVVPFYKYKYVEYIKQLETRILEAIDSGYFYDSMGKQISFYTPEGLNYLGNIIEGNCDSFNIKYYGAYDVLARDILGMNFDCKCKDYYVPSALQLFSTSMRDPAFYRLYDRILFFFHKYKSHLTRYTKTELEFPGVRFEGVEVDKLFTYFDKKEYFINNAVAVDSFKEGKSFSIKALQYNLNYKPFTYKFAVNSDKDTKAVMRVFLGPAVEGDKYDDYSYLLHYYQYFFMLDEFEVNLKSGINNFDRLSTDSFFFKGEYMTGDQFYKKVLNAIEGHAPFQYDNRMFGFPNHMMLPKGKVDGMRFKLFFYLGPYEEVKSFELPIFGNFKYYGKSFGFPLDRPMFPWFFKLDNCYFKDIFIYHLKDYDIKFSHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETR8</accession>
    <name>A0A232ETR8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_000504</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002259">
        <property type="protein sequence ID" value="OXU21707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETR8"/>
    <dbReference type="STRING" id="543379.A0A232ETR8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU21707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="59906" checksum="7AF7EDBAC46999C4" modified="2017-10-25" version="1">MTSVYLALILFGLVIFHAWIRYRRMGRIVDKVPGMRPLPFLGNMLSLMGDKDQLWNIMRSLAKEYTITRIWFFTRVWVAVRDPDDIEILLTNKANLNKRAVYELALKWLETGLLTSGGEKWIHRRKIVNTGFHFNIMKKYVKISGEHAEKFVEKIKSHGDEYVLDLVPLFSDLMLQIICESAFGVDLNKLDQKLVQQYKGALHVMYDMVIYRSTRPYIRDWMMNFLPIGWKQNRAINILHNFTNKVIQERREYYNKHASENRSYQSFVDDVDTESDDVADGRKKRLVMLDVLLSAEREGLIDAKGVREEVDIFTVAGHDTTAVTMTFMMMLLAENPEIQDRARAEVIKHFEENGGKLNITEIQKFEYLDRCIKETLRLYPPISQFVRYMDEDVQLKKYLIPAGVDVLFLTYDTQRDPRHWTEPDKFDPDRFLPENAKKRHPFAYIPFSAGLRNCIGQKFAMLELKAMLAHILYNFYVKPVDLTANMKLETYIVLQPSHPVHVKFIRRNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU25</accession>
    <name>A0A232EU25_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_012184</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01002209">
        <property type="protein sequence ID" value="OXU21796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU25"/>
    <dbReference type="STRING" id="543379.A0A232EU25"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="13">
        <location>
            <begin position="276"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="522"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="16">
        <location>
            <begin position="755"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="976"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="980"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="623"/>
            <end position="625"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="630"/>
            <end position="636"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU21796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115880" checksum="502B385742D6A611" modified="2017-10-25" version="1">MVRKKIDNRIRSLIEDGVNCGHRTMFVVIGEKAKDQVVLLHHILLKSAVKAQPTVLWCYKKDLGFSSHRKKRMKQITKKAKSGKLNFNEDDPFDLFILSTKIRYCYYSETHKILGSTYDMCILQDFEALTPNLMARTLETVQGGGIIVFLLQSMNSLKQLYTMNMDVHQRFRTEAHQDVVCRFNERFLLSLASCERCLVVDDQLQVLPISSHNLNQKPSQRTTIDTTELDLLKKSLQDTQPVGAIVNCCKTSDQAKVLLKFIEAISEKTLRSTISLTAARGRGKSAALGLAIAGAVAFGYSNIYITSPSPENLKTVFEFISKGFEALNYQEHTDYEFFQSTNPEFNQATIRVNVFRDHRQTIQYIHPTDAKGKLSLAELLVIDEAAAIPLPHVKAMLGPYLTFMASTINGYEGTGRSLTLKLLNQLRAQTVQTNSVNKQEKDLMAKAVIGRELQELVLEEPIRYRAGDSIEKWLCDLLCLDATTVSASMSSGCPTPEDCQLYYINRDTLFSYHKASEIFLQRMMALCVSSHYKNSPNDLQMMSDAPAHHLFCLLGPVNPDTKTLPEILVVVQICLEGQINKSTISDGLGRGRRAAGDLIPWTVAQQFQDEDFPSLSGARVVRIATHPDYQGMGYGSRALDLLRQYYQLCIPSLEADDVETEAQTEASQVQDSEVDLLEESIEPKSSLPPLLLKLSERKPEHLDYLGVSFGVTESLLKFWKRAKFVPVYLRQTTNEITGEHSCIMLSNLQDTSADWLKAYWKDFRRRFISLLSSSFRDYAPSLALAILTNNTIKLPSETIQKQILDTYFTSYDVGRLEKYSSNMSDYHLIMDLVPPLARLYYLNLMGSVHFSPVQSAILLSLGLQHKTVDQVVEDLNKTSTNDTNLLLASQVLGLFNRIVCKATKYLNDVIKNDVGSAFKEIKDSSENVKVDHQNGSDMQKELEAADKELKKKQKVELEKLKQTSLEQYAIKGSEAEWSNALKSNKTNKNLLSVKSLEKRANSNNEGNQSFQEKGSGNKKKGKKRKHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU26</accession>
    <name>A0A232EU26_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002187">
        <property type="protein sequence ID" value="OXU21851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU26"/>
    <dbReference type="STRING" id="543379.A0A232EU26"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7088" checksum="E7EBDFC12581EF3A" modified="2017-10-25" version="1">MKKMESDIRKEVDDAVKIAKTDNEIPLSELTTDIYAYGIEKEIRNTTPFQPLLHSNLGPAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUF9</accession>
    <name>A0A232EUF9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DPH-type MB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_016561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002130">
        <property type="protein sequence ID" value="OXU21990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUF9"/>
    <dbReference type="STRING" id="543379.A0A232EUF9"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="304" mass="35168" checksum="AB86C2E6E1DD9277" modified="2017-10-25" version="1">MTAYHDEVEIEDFEFDEDTETYYYPCPCGDQFEISRAELLAGEDEATCPSCSLVIKVIFDKDNFIAKFEEVLKIEEKELVKTTSFRRTMAGRGRGRGKSSLALPGDPGIGKGEVLPPILQPPPAYPPLDFKPLPTTITNELRYLQQRKKEFADFMHESFNNVLPIVVKKDIERYSDRYQDLSSTVKYHERYDWSRMPAELKPQVKKRKGDKTQKNAKKKKKDIDIESKLQELEKKETTANQSDAEDGDKDDDESEDKDVEDKVELEEEEIDEEMDEGTDYVNNYFDNGENYEDDEENLDDGAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUS0</accession>
    <name>A0A232EUS0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_000661</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002090">
        <property type="protein sequence ID" value="OXU22109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUS0"/>
    <dbReference type="STRING" id="543379.A0A232EUS0"/>
    <dbReference type="OrthoDB" id="426657at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16550">
        <property type="entry name" value="RING-HC_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051657">
        <property type="entry name" value="RNF168/RNF169_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328:SF0">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="461"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="532"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="655"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="852"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="763"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU22109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="894" mass="100514" checksum="B757069D56044B7E" modified="2017-10-25" version="1">MATYLKRPSKLFERLAAVSSKNSSSNSSSSEEPQRQQPQLRELICPVCRSLLREPVTLPCAHNLCLSCLRGTVEHSSLSCPLCRQRVGSWLRTATNRQDSLVNDELWQLIRRTFPEELGLAHDAPDLDLAAAPLPLAFRDYYPAKKQISAPGEIRREYEVQLQMVEEEMRRQREKDRLASEAIIRKIQQEEEQQKLVQLAQDQLLAKTLAKREVIDKTNDKPQRSAKSTTVVNSDRSNINVNTNANQSKPGSNQKMSVKSKEQNDSRKLNAALISKIRKHSSTVKSSAANSQKDSTETFSSQKPVPIHNAVTRVVTHQSRGSQPNSTIFQALGEVVATTSKIFGLQSKEELHVPSDVLSSNKKKLGVEVCVTTVEGEERIGSAESAGSHDSINQEIHHFKPIKALPRTPLRTTSDGRQVDPKLIRVVPKLKRISNAVPKPPTPTHLKKAFSCSWSAFKKITKQQQTSKKNSSNVQQQQETKKTERKGDHSRVASKSRKSLQVLERNSEVDFDSNKNYTKNVGKIVNGTKVSKKLNLDEQPNERTIKQQSRRTGKKNGQLRSNKHKSKKEPIELVELDDEEDEQQEQQSTNRIPTPDPLELAPKQQEQSRPDSPVFEMTIMENIAERIKRRKTTRTASNTENVQCAMNLVAPAVTKAKSKKTSTKIRKQTKTKKPAATVVKQKPKVEKVTSVTSQIKKLAARSAKRPRYTEDTESEDEDRIIDQQRQSQLSEEQRQLEENEGAELDKSNLDRSPTPPALPSPPKKSRKSAKTTTKSRGKSKSKSKSKKQSKAAEPVLPAPSPTLLESSLNVSEEIDDDAALQEQARLERLAAQEREDRELALKLQAEFTALERVAGRTRRGSARAPSPLIETNNEEHKSKKDSNEKRPRKRAVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVD0</accession>
    <name>A0A232EVD0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_013326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002025">
        <property type="protein sequence ID" value="OXU22278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVD0"/>
    <dbReference type="STRING" id="543379.A0A232EVD0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000086">
        <property type="entry name" value="transcription factor E4F1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000380">
        <property type="entry name" value="zinc finger protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001111">
        <property type="entry name" value="Zinc finger protein 92 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="561" mass="65347" checksum="B82D392A6D596930" modified="2017-10-25" version="1">MDRRWARHESRDVKLPIDSQVMDENIVSVVLKEEPGEKFESSYMEDICLGTFDKVFQPIDQQEVEFPDDMVKLELDGDNSHHHWAAQLASATLSENGDYSGQGDYHFLNSSAAQKFYKIQCILCKKWFLNNDSMVTHLKMHCTGNTCEVCHQSFMDSAGLHAHMLTHVGMSPVECTICQKRFAYKWCLRNHMQTHMQNKQFEYDSLQQAFLKRYGSGNDHTMRDEERPYTCEVCQASFREKGNLNRHMLIHTGEKPYRCEICFASFREKAKLNIHMPIHTGHKQFKCTMCHRSFAQKTALNNHMLAHNGEKPHACNICEKTYKRKSELIRHAMIHTGERPYECQECLMTFREKAKLNSHMLVHTGEKPHECHICHKACARKSDLNSHMLSHTGGQYDCKVCDKIFTRKSDLNRHILVHTGEKPYACDYCEMAFREKTRLNSHMVVHTGDKRHMCHICHKNFREKSMLRKHMLGHTGDRPFECYVCQKAFTQKSTLNSHILTHTTEASYECTICRKVYRERMALRKHLISHTADKNNECPICLKKFAHKAALSSHITTTHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVG5</accession>
    <name>A0A232EVG5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002015">
        <property type="protein sequence ID" value="OXU22305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EVG5"/>
    <dbReference type="OrthoDB" id="10009983at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1266"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1622" mass="178084" checksum="18E2651DF8DF2FC9" modified="2017-10-25" version="1">MTAVPNLGVCNHKFTKRRFKRGTSGPWNYLQNSTYYHVTDYGVFNRVNLKSKRLDLLSVGSLHLSAAEAAGEVTLGALDSGDNMYSEWASLSILIQQGSEDSQSVLEKFAPGVGREVTLSIVRQLATNLGIAQAAEPSPLNTDKEVRWCMEVICFGLSLPLTEHDTVRDCVNVYCEWLSALYTSPKISVPKPIADDPNYYARKIIGHFHNLFVPRKGEGADTINKQAVLCHRVLRTLQQVARISANLERETWESLLLFLIGINDALLAPPAIREDTGEQLCERVLGVLLEVWLVACERNFPSPPLWRTLRESCLRWRHRLSLIEQWNRVCLALTARLLHIMYGPMFPELKISEEDSQLVSSTMSNEAVAQAWYRLLRTIGDPVDLCRPAVISQTQAFLRYAIASPNVVDPCQHPCLQQLPYIFLKAIKGIAGQVDAQIAQRVCGDGGGGGSVNKPCFAGIAQACCWEECCVTSLGISGGGGSSSIGLTGSTVGLTSISGDRIMKDQPHPSPTPPTQRRLAKSFSVTPSAVTKGIPKASLIGLTTSRVTSTPLMSTNSGPSSTSSTTSMVSLNQDARPPLASGRPKCNSILHLFGEWLFEAAFIGTDGWSQNLPQPNNAPKRPSSVLVDGPSSLQENIGEVPPSLSIDRYESGRAEAMGTLCRIFCAKKTGEEILPAYLARFYQAMNHGLKVNRFSDVRECGETLASILSNSADLFRLDLDGVQVLVPAVLSALEVVLPEKDLRLKSNAVSKVELRRSSIHLLLSMLSLPLHFQNLQIKEIPTASLINHEKIPITFAQLKPKLMNLLINALQVEVDPQNTHMLLGGLLLSVQDSAAAEEAEQVTQPDSTISNESTTNLLSSDSAHALFVRATYLVCHRLISSWKTDLNISLAALEMLSGLARTRIRETDALECKRAVKWLCDYIAYQCWRPPPAHSKDLHSSIVAAFACLTTWLTAHPQLLQDKECLATVLEVVELGVSGSKSVGKPGEPIKMKDEKELKPASMRVRDAADALLTIILEQVGYFPSVCGAESLSSLLDEVSLLRHCNSWPGGRQVPRETAVERFRYFVADNATMLALLEEPLGNDQDPQPTVTVLIRGPFGRHAWTMQLRHLPRHRSIVRSSNTNPGRPLPLQETQPPTDYKPRFFPDNVDKIPHCKVDESIPSLEAVMNENDLVKNEHQLLHQLLDYAIGSEAKSNEENANRVASAKMNECSPPKICHEFQTARLFLSHFGFLNLESNAANNDISSAGSGGLTALDPTIAGFANDLESLDHISARTCDTVHIFYVKSGQSTPEAILANVLNESNVSSNFLEFLNSLGWQVSVTSHAGWTGHVQTSWRSTSTSSVSANAHVVQPADEEEHGGALYNGSRHVLYWADVSSEVAFVVPTWAANVTTSETADNNFSEPANGKCVSTTAAQAFSNSHAVTGQTRAMSLDLEKQSANMASSAAAAPIEPIKPSRRATKHSFPAQTDTKIMVVWLESLEDYAQFPIAGLLPHTHTGLDHSRTMQACDVHVIYLQALASGLMRIKLQGPTSRMNLATPLIDGMVVSRRALGPLVRQTALNIGRRKRLDNDSYHPPHVRRRLRIQDMVQKYKRNLQQPELLTLLFNSTQIIRKAIQSNLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVJ8</accession>
    <name>A0A232EVJ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">small monomeric GTPase</fullName>
            <ecNumber evidence="1">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01001983">
        <property type="protein sequence ID" value="OXU22382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVJ8"/>
    <dbReference type="SMR" id="A0A232EVJ8"/>
    <dbReference type="STRING" id="543379.A0A232EVJ8"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008544">
        <property type="term" value="P:epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032486">
        <property type="term" value="P:Rap protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04175">
        <property type="entry name" value="Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000182">
        <property type="entry name" value="ras-related protein Rap-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038851">
        <property type="entry name" value="Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="184" mass="20903" checksum="BEDBE4BAB745E8F0" modified="2017-10-25" version="1">MREYKIVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDGQQCMLEILDTAGTEQFTAMRDLYMKNGQGFVLVYSITAQSTFNDLHDLREQILRVKDTDDVPMVLVGNKCDLEDERVVGKDQGVNLARQYNCAFMETSAKAKINVNDIFYDLVRQINKKSPEKKMKQKKKSLCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVK1</accession>
    <name>A0A232EVK1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001991">
        <property type="protein sequence ID" value="OXU22367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVK1"/>
    <dbReference type="STRING" id="543379.A0A232EVK1"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000060">
        <property type="entry name" value="WD repeat-containing protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="744"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="969"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU22367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115585" checksum="CF5C2B3C99E9FA92" modified="2017-10-25" version="1">MSASSDSEEFFDAEDDTTNRAPRKNRHRESISTESHDEKFSTPSAKTESHVFLKPADPKPQPPSEASEKTISEEPEQKQITEKTEEETKGAGADKIVGRRKFRELRQRMQTEDDDIPINSSPPDSQTSSIEGVFPTPSKTSHPFRIIEHDTLSLQSMTSLGRVGRILAGASDNTSQVLAPGILSTAQAASVLPRETQMAAIHSVSSKDEDTASDKLSQSSSVMTLSGDVLREPSLNGKSDQSSSSQCDKTTVLQEPDVIASTKSNGKATEILAIPTKMPVAPPRRKKKTKAQTPNDLVSTNKEILLSTSSLPSPASTIESITREFEHSLDIRSATKGQYVVKPQMSFYQLYLKLLQDEDKAKAEGPSSEELERLAKLKAELMSAKTGDKSSNALGSIVNNSIGRHSLGPHKITGLNPHGSRERRKSAGDQDLVKQLNMFVRTRTDSGKRLTDMEILEQVTVLNLDTGERVPLSIAEDKLPQCINPLSLHIMRLTSEYISNSSLEKEKESDEESVDSKMSSIPPDEDVTVGRVRKRTQKLRRFFGSTVKKTMDKAKSIAQEVSHARHKEDVMDIVDDVYPGEQQCIKLKASNSHKGPYEFYCLQHVQDLSGEHSGPVWCMKFSACGRLLATAGQDRVLRIWVLRDAFAYFQDMRTKYNAEKVSPTPSQESLVSQQSMEDPHAMANAQGYAEGSKGPFMPKPFCTYTGHTSDLLDVSWSKNYFVLSSSMDKTVRLWHISRKECLCCFQHIDFVTAIVFHPRDDRYFLSGSLDGKLRLWNIPDKKVAVWNEVDGQTKLITAANFCQNGLFAVVGSYDGRCIFYNTDQLKYHTQIHVRSTRGKNSTGRKISGIEPMPGEDKILVTSNDSRIRLYDLRDLNLSCKYKGYVNVSSQIKASFSPDGQYIVSGSENQCIYIWKTHHDYSKFSSVRRDRNDFWEGIKAHNAVVTCAVFAPNPDSIIRQIEAREQQMEAAKNAEGAAAAGGGPSMGKNSGDSASTDATPVDPVVEQRTKGCGGHVLVSADFTGCIKVFLNKTKPKHSSLPASALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVP1</accession>
    <name>A0A232EVP1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001972">
        <property type="protein sequence ID" value="OXU22416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVP1"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027871">
        <property type="entry name" value="DUF4603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611:SF3">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15376">
        <property type="entry name" value="DUF4603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="249" mass="27664" checksum="66BB9B2326BCF3C9" modified="2017-10-25" version="1">MRNPALHLVGIAASPGGGGVFGTRAEEELRHWLEQRLDALGIDPVAYSRFVLSLLRRPDSAFTPPLDVATIGRNGGGGRRSKARPRSKLPLQGDREQRRAVVQCLTNAADQTCGVETLVDELCAKLRDLEGGDSKDEQEELKTATDGEAKVPFETLTPRDRALRYYAAFPALQPTTPKKFPHRKERNLSNNNNNNNNNNNNYNNNNNNNNNNKKSNGISSSNNNKTRQKKNKMSIVSTCPVIFHCHFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVQ4</accession>
    <name>A0A232EVQ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">TBC1 domain family member 15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">GTPase-activating protein RAB7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSAR_013374</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">Alberta</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction. Interacts with ARMC12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001967">
        <property type="protein sequence ID" value="OXU22427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EVQ4"/>
    <dbReference type="OrthoDB" id="6375837at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006605">
        <property type="entry name" value="G2_nidogen/fibulin_G2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034754">
        <property type="entry name" value="GEMIN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07474">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15348">
        <property type="entry name" value="GEMIN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00682">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54511">
        <property type="entry name" value="GFP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50993">
        <property type="entry name" value="NIDOGEN_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012986000" description="TBC1 domain family member 15" evidence="22">
        <location>
            <begin position="28"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="26">
        <location>
            <begin position="106"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Nidogen G2 beta-barrel" evidence="25">
        <location>
            <begin position="320"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="541"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="587"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="669"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="808"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="884"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="928"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="972"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1014"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1149"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="20">
        <location>
            <begin position="1192"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="24">
        <location>
            <begin position="1620"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1384"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1912"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2004"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1923"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="2013"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="894"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="982"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OXU22427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2128" mass="238314" checksum="58F2273C7427A258" modified="2017-10-25" version="1">MARGVPIRASFGALGALLVLVLATIQADALSRNELYPYTTPGAASLQSQPDGMVRTAELMLQTPIKLYDKEYKSIFVNGNGVLSFIRPMNRFFNIPFPLDDPVVAPLYTHVDIRASGTIFLAETNSSDVLARAGGLVRSSFKNAVNFVPTHVFLATWLDVGYFNEKKDKVNTYQVAISSNETHSYVELLYPEGGIQWIQGESHPNGLPDAKAQVGIMGEDKMYVLPGSGTDQIQNIDKWSNIHRPGQWVFQIGPVAEGQDIGHPDNVDDKLAKDQVQSCRSGGATHCHSKATCIDYEMGFCCACKQGYFGNGKSCQPNDVPLRVIGKVSGKINDHEFTDRDLQCYVQTKDGRTYTALARIPVNIGDRFQLLNPMSGVIGWLFAKTSGETKNGYQLTGGVFNHTIELIFKSTGDKVTIRNSYLGLDVFGQLKMESEIKGNLPPVEEGARIDFGDHEVLLTRVQPGTIRSNTERKYKLAANPSNEYLFSEDQVIYYNECSYAPPSDAGDDTSRLKFSRGITTYESREGIVRFAMNSKIVPLEEEDPCIQGRATCGYHSSCVADADSFRCVCDPGYQQLYKEDGSSSCVDINECNMGNHVCSPDAYCVNTEGSHTCHCRPGFSGDGRTCEKLASCDDTRCGDYEQCIMTSGTPVCTCIPGFENTPNGCYPITRTPCDQAHDCSPLATCDYSEDRQAHVCTCAAGYLGNGYECYPDTDAGIVEEETPIPKCHVEMCWCPVGWEFQNSMCIRDDEGLPDHGSGEIMHELMARPLPECLDDRCICPWGYDYDQLENLCVPRPGLIHETMGPSGSNTPCNVLNRCHPYAQCVHDQNSEQYMCQCNPGYEGDEISCLDVDICDPNASCRQDDPIAKCVCNTGYKGDGTTCSPYDECREHKECSENEWCSYVPAHSRFECTCQPGYSMVDGQCVLADXXXXXXQQCHVNAQCVSSSDGLGGYHCACIPGYHGDGLRQCVEEHVSCSEVNNCGRNAVCGYNQTSANYACVCLPGFYGDGFNCVQQTSCRQNPSLCSRDASCLPLGGNEFTCVCNEGFIGDGADCRPRPKHEANFLLVNQGMATHRIPFFPTPESPGNPIYVAYHQMAIALDIDCPQGKAYASDITGNKIMRMTYNGSKSESFIGQVSSTEGIAIDWVSRAVFWTDSGNETIEVAHLDTKKRKILFSEGLINPRGIAVHPYRGKIFWSDWYRPAPKLEWANEDGTGRQIFLTGEHVKLPNSLAIDWYTDELCWADAGTFTINCANIDNKSVRVIAKNLSYPFGLAISQNHYYWTDWKTGKIEVAVKSTGERGPSISLPAGGSGKPYGIVIVPETCPRASNICQYENGRCTEEQLCLPDGQGGRTCSCADNASFGKCIEWKPIEVSVVSENQDQDPEWSLVDTHTSRTRSLSEGPDSLGRRTVRILFSELKSIRVHHSGQQLVFMQKDGTTYVAFFQLLNAESFLNSLKGFIKFVKSKQDRYLYLVFDEVSSNLNKSFAELDIFQENTSDYVWKFVKNLHNHPYETTMEAFSKLADVWLYKEPVKRPVEEAVADLLNRSLTVNVPQPPVSVGSGEEYEVIGDPGLGILLPPRPPCPRGSGAPLTQEQWDKCKDTEGRVLNPETVREIIFRGGISPSLRYEVWKFLLNYYPWNSTNIERVELRKKKTDEYFAMKLQWKSMTAAQENRFSDFRDRKSLIEKDVNRTDRTHAYYSGDNNPHLAQLYDILMTYVMYNFDLGYVQGMSDLLSPILCLMDHEVDAFWCFVGFMDKVSTNFEMDQAGMKAQLCQLHNILLVTEPQLAQYLDKHDSGNMFFCFRWLLVLFKREFNTVDIMKLWEILWTDLPCKNFHLLFCAAILETEKSILMENRYGFTEILKHINDLSLHIELPWTLSKAEGIYHQLMAVAPQLPDNVRVVIGLKPLNKSSEISDQEDEDSSNGANNANGESNSSSTNTDEGGNIKFGNNEVSFERSLNLSYMHNVTWWKTRCFALEHENHVLKETIRNLTNNQNYSHNLVESSQIHQQNEAENEELNDGNENNADDNLEFQLNEDMMNFLAQSIRHKIELKNKKESEEAAEQSEKSDEEPIKHGLAWIRKRNDCAKLLYGEASARVLAMETALQTTIERHIDKAKPQYWPNIPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVR4</accession>
    <name>A0A232EVR4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001960">
        <property type="protein sequence ID" value="OXU22449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVR4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7770" checksum="F5717017FD3A3E11" modified="2017-10-25" version="1">MQNSLQHNCRVHMYINTAVPISLKIIITAHEKLSLKQPESYLLRIAKSTRPPTTSISRLSLRRVFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWK0</accession>
    <name>A0A232EWK0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminopeptidase N</fullName>
            <ecNumber evidence="5">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">TSAR_004655</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">Alberta</strain>
            <tissue evidence="30">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001852">
        <property type="protein sequence ID" value="OXU22728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWK0"/>
    <dbReference type="STRING" id="543379.A0A232EWK0"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000033">
        <property type="entry name" value="Endoplasmic reticulum aminopeptidase 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14 23" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="29">
        <location>
            <begin position="100"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="27">
        <location>
            <begin position="327"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="28">
        <location>
            <begin position="660"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="964"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="22">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="24">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="OXU22728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1008" mass="115702" checksum="056D9D715D2520AD" modified="2017-10-25" version="1">MTKSLGAMGMDDRTTTFGRKRGCTVTRCGAFALAMSFFASVVVTGLLVYHFAPCIDASSERRYNRGAGDDESTMFRSGRSFAGSSSKKKLDVRLPTNVRPDSYELQLVPFIWEGNFTFNGEVKIVLNVTEDTRKITLHAVDMDIDEEATSLKDYPWIEGRSKNLRVSRQYNDTARQFHVIQTVETLKAGKQYLLQLKYVGRLNDYLQGFYRSSYTVDNQTRWIATTQFQPTDARRAFPCFDEPALKARFQISIARPSNMTAISNMPKERESKPVAGLPTYVWDHFERSVPMSTYLVAFIVSDFESLHSSQGNVSVWARKEAVQQSDYSLKIGPEILEYFEDYFQIKFPLPKIDMVALPDFSAGAMENWGLITYRETAMLYQEGVSTSNNKQRVATVVSHELAHQWFGNLVTPSWWTDLWLNEGFASYVENIGINAVSIFIFIFICTYNVYALTERNCDRSKVEPSWKALEQFVVHELQNVFGLDALESSHPISIAVGHPDEINEIFDRISYAKGASIIRMMDHFLTTAVFKRGLTNYLKGKAYQSAEQDDLWDALTKQAHEDKALDQDVTIKQIMDTWTLQTGFPVVTVIRDYDNDAALITQERFMLRNHSKVESQPLWWIPLTYTTSRKLDFNDTKPSIWMKAERSVPLKNISASSQEWLLFNILETGYYRVNYDRANWQLIIKQLSGENYGAIATINRAQLIDDALNLARAGRLDYSTALDVTSYLAHETEYLPWKAALTAMSFLDNMLVKFQGYDKFRVYALKLLDNVYRKVGFKDSLEDPQLTVFTRIDVLSWACNFGHEDCVRNAVSQFAAWRQSPEPSRNNPISPNLKSVVYCTAIRVGGQPEWDFMWQRYLETNVGSEKDLLLHALGCTRETWLLSRYLDWALTDNAGIRKQDVTRVFGSVSSNIIGQPLAFNYFRNKWDRLKEYFGTSLMTINNIVKSSTKRINTKYELKDLLEFANEHKEELGSATRAVEQAVEQAEANIRWLERNHATIHDWLKRNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWQ6</accession>
    <name>A0A232EWQ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011664</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001829">
        <property type="protein sequence ID" value="OXU22778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWQ6"/>
    <dbReference type="STRING" id="543379.A0A232EWQ6"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000130">
        <property type="entry name" value="neural Wiskott-Aldrich syndrome protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF36">
        <property type="entry name" value="ACTIN NUCLEATION-PROMOTING FACTOR WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="10">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="9">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="11">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="11">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU22778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59012" checksum="5953EE117B036FEA" modified="2017-10-25" version="1">MKSGSVNEHRGSILLKPEENEQVFRLIGNRCQCLAAGIIQLYLTEPPKHNEWIKKNTGIITLIRDTSKRSFFLRLYCIQRKAMLWEHEVYNSMEYKAPFNYFHTFEAEDCMAAFNFANETDAIVLRNILIEKLNAKARRRNERHSKMEIENQRGMMLPRKNQSISTPSLGLTHNPPDNFSNGTPVAINVNRSMSNISMSKSKKKKRSHEKEAKKKLTTNDIGLPFDFRHVEHVGTDINSCRVIDPELKAFFDKVGISESHLEHQETRDFIYDFIESYGGMNAVKKEIKPASATPTNVQQQVPKPQPKLEPPPPVPARTIPVSTNALSNNSHQRKAPPLPPVQTQSQVPPPPPAVPPVHRSLPSRPPPPSAAPAPASALPPPPPPPPMPQELPSKVVTNAPPPPPLPSMGSSPRDTDNGNSANDNKHQAPDPRSMLLESIQKGVNLKKINKEETKSVTPRDPRSNLLEEIRSGITLKPVANEPRPNSATPNVAEGGLAAALTRALAERSRAMYSESEDSSEFSDNDDEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWY3</accession>
    <name>A0A232EWY3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001814">
        <property type="protein sequence ID" value="OXU22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWY3"/>
    <dbReference type="STRING" id="543379.A0A232EWY3"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF167">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12344" checksum="C23EDCC0598E3B14" modified="2017-10-25" version="1">MALARKRRQFFGKFTIVYNSEYEEEQTPRYRPDSLASLCRATRFTEAEMKRIYRGFKAQCPTGVVREETFKIIYSQFFPQGGESSYCTSCSAFTAEIIFKRAASRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX39</accession>
    <name>A0A232EX39_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box/LRR-repeat protein 15-like leucin rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001779">
        <property type="protein sequence ID" value="OXU22942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX39"/>
    <dbReference type="STRING" id="543379.A0A232EX39"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="224"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="385" mass="44802" checksum="8772BB5BCB41DA22" modified="2017-10-25" version="1">MYKAILKRSGRYLTVVDFTYLCAKPDDHDKFILNYRDIAFNTYFNNSTKKRTFEGIRALTSNCTKIEKLSLCSLIIDCNDLHLSRLFSKNKNISYLNLVNYTFTGKCFSKLSAESITTLLIQRCQRLQYENLRMLLSKCGNLKILSLWRTTTENELFDQHVIEFISSSNAKNLEELYLGDKMSYAPLQRLSYFRLDFALDNLTCIQINNALHDQIDQILIDIGANCKNLKMADFSGCSEVRDDVLMNIITLPKLEILCIDGLRWITERSLVRLSEHLKVLRCAECRVSDAGLRDILITSPNIEILDVSFCPKISNEILHYAIKLTKQRTNNVILNMYVSNTLTEEWEIEEISPFFKLHKVSYAPFFSRFDQRECFQVDSTFYIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXL1</accession>
    <name>A0A232EXL1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001734">
        <property type="protein sequence ID" value="OXU23092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXL1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="25" mass="3117" checksum="CD50BEFAAEF09477" modified="2017-10-25" version="1">MNFLVVFVRIEILLSPILRFKWLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY29</accession>
    <name>A0A232EY29_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001702">
        <property type="protein sequence ID" value="OXU23180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY29"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12152" checksum="48E643064ED67ACE" modified="2017-10-25" version="1" fragment="single">MALRIRLYTCAPFVHCRIRAAEKLEVLQSPRSGLEESMNITGMSADCSERGENLGMELTKVAAWLLIEGKMFGSFQRSGCRHLLTKSSVNFDPPSTEEDLRSEEKRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY77</accession>
    <name>A0A232EY77_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAM60A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001635">
        <property type="protein sequence ID" value="OXU23362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY77"/>
    <dbReference type="STRING" id="543379.A0A232EY77"/>
    <dbReference type="OrthoDB" id="10023333at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026065">
        <property type="entry name" value="FAM60A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13422">
        <property type="entry name" value="SIN3-HDAC COMPLEX-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13422:SF12">
        <property type="entry name" value="SIN3-HDAC COMPLEX-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15396">
        <property type="entry name" value="FAM60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48497" checksum="C4F7192A43C8CAB5" modified="2017-10-25" version="1">MVFILLCYRKRRKVAKAKMFSFHKPKVYRSSTGCCICKAKSSSSRFTDSKKYEEDFVKCFQLEERRTGEICNACVLLVKRWKKLPAESDRNWRHVVDARAGPGIKSLTKFKAKNKKKAATKEEPEKFEKILKKKKHVCLKNDRDREQSPAMSDGLTGIGIPDFQINRAKTCNKQSICVFAEEYLPGTGSKGSSRAGSPADSDDIAVGEKRLDIDQEQEDISNFIDLTYFKRKNVCCGVIFVGMMGEVLIEPSLFKPCIGCLARQQRQRAAAAAATMAGASPAHSSASASPCHSLASTSPAHSVESGTEGSVVSGKGKGFCDSSSDSGYDDSNQGIAGESKKHHQQQPPKPPTAQTLDVSAKPIKPVSKVQALESDKIMPVSTSVRLKENSIGGTKVPIKLLCKPVALVSSAKLSLSGGTPLAVDAALTVPTAVDFSLRSASQRQSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZR5</accession>
    <name>A0A232EZR5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_007271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001506">
        <property type="protein sequence ID" value="OXU23760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZR5"/>
    <dbReference type="STRING" id="543379.A0A232EZR5"/>
    <dbReference type="OrthoDB" id="5578278at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="10">
        <location>
            <begin position="385"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU23760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="801" mass="92752" checksum="FB60DB56C22B0A8D" modified="2017-10-25" version="1">MQFQEKWTDLEKGSCPNHHIFKVQSAYDGCHCPSTINFTQCAFDTNDEAVVAVDNNGIAYYIDITGKPAYRKLGTVGLCTFITFNPKDRSELLIGLSSTNIKVLRINAINDFCLLTGHTSPPTNISFYKDYCLTASNKEVLIWQAKSYSKAHQLRLNAKTIVIKKAVFSSLGIVAVLYLTDIIQTWTFQQFDKDNKIDVEKHGLKNVKDFDFTKDGRAMIVCGLQNKILVFNTSRWEVLKSMEFHENFNGGKQILVVPLPLDGGANSITVVLTSDCLLKYFSLATSSIIENCCEVQPGIKRIEVSPKGCFLAFISKHGFLEITHLDKVLNVKLCSSSSSEKTTKSKVQKMAHSHKTQEQLKCVHDAVKEELNLDRLIPILKEFGEYPEKHRRLIWMTIMELPNNKKAYIDLSNKVPHEAMFKLLKNDPLLDKCKSSTLGTTISCLLHWCPALAECLFLPKLVMPLVNVFQKNPILGFESSLYVILNYCQKWFEYHPLPPLNILGMVENVLLEADPLLFNYFCEKGVTSTHYAWPLLQTLMSEVLGQEDWLILWDHLLSLQKPWYLLMCTVAYNIIYRKTITTRLQTMEDFQQFYSTKGHASVKSILKLAHKLDVDTPHRIHPRRYLKTGTVIIPNKGPYPPFLQFEFPHFLTDELRGLNLKKLKDKERRLRGFQLHAMELLEEKRLRAESENFVKQIHEMRLNELRKCYENQVLEDERLLEYTKKETEDLDPSNYLPDDMRWSDLSFSDRRSAFLKDFDRKRRKSKRKNCRLLQEQVDRLEFEVQNLLATLHTHRARSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZZ0</accession>
    <name>A0A232EZZ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">REST corepressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_010314</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CoREST family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001465">
        <property type="protein sequence ID" value="OXU23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZZ0"/>
    <dbReference type="STRING" id="543379.A0A232EZZ0"/>
    <dbReference type="OrthoDB" id="10064338at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1880:FF:000001">
        <property type="entry name" value="REST corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000033">
        <property type="entry name" value="REST corepressor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000002">
        <property type="entry name" value="REST corepressor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049048">
        <property type="entry name" value="REST_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF28">
        <property type="entry name" value="REST COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20878">
        <property type="entry name" value="REST_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="385"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55032" checksum="97BDEF66F40E98A5" modified="2017-10-25" version="1">MVLAERNSESVRNGRRSRGPSPNGQTESSSEEDGVPAEKIRVGRDYQAIVPELIPINDKKRKPDKCPERALLVWSPTIEIPDQKLDEYIVCAKEKFGYNGEQALGMLFWHKHNLERAVLDLANFTPFPDEWTVEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRTKTSLMDRQARKLTSGGKEGENGSENGSDLVSNTDSESEEKFECGTFQKWTIHRGIRRGKNQTAPGSQGADAKASSDSENVPLVQGSCSNCGVACHSVRSTPKGHACHSCYLHWRRTGVARPLSSMPGRSNKRKPPRGLVVNHDDLAALAGQPNQAISTLQAIDTEIVSLKRQSCLPKQIQSNKQQVSALKRKTSDGIDELRPQENSSRINSRWTNDELLLAVQGVRKYGKDFSAIADVIGTKTEAHLKNFFVNYRRRYNLDAVLKEYEAENGPILIDDDKDDKMEVDPPSNSESAESSQKTQKTPTAQVNQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F069</accession>
    <name>A0A232F069_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001452">
        <property type="protein sequence ID" value="OXU23930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F069"/>
    <dbReference type="STRING" id="543379.A0A232F069"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="11675" checksum="367E2986D68A660B" modified="2017-10-25" version="1">MQSQINENILEDSKTDKDEEYCRKINEVLNNPPTPGSQRSSGANAEGDLQNLLNNMSQQQLMQLFGGVGQIGGLGSLLGTMNRPFSSGSRISTTSSITPWLGSSNQGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F078</accession>
    <name>A0A232F078_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001455">
        <property type="protein sequence ID" value="OXU23917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F078"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="828" mass="86738" checksum="D2D530494991F8FC" modified="2017-10-25" version="1" fragment="single">MDIDTEQQEKHQQSHGVSVKRGVDFQGPASSEPSVERVAVSQAPASSKSPVKRVTDSQPPVSLMSPAGTVVSPSPSSRRPSSSSLDPLNLPKKFSPTDEPLGEISLLRVSNILIPVTTMELFFQRFDMLQDQLDELKALVSRDSASRGVSPAPTEGAATVEAENLNTRVSALETQLIDNINASNKLFDVNKLLLDENSTLRDELRKTQQLLGDLHRGRRNPNSESGTGSDSQSASSGGLLTACSHVLGAGAVTEVAGVQASFSLHIAPISGVSLSDEGGSEGCEVIIRGLLKDSNKISKELSDGADLALLSTVLPSLSGGDIVVTRKNAMCDRCRALSTNRSLTPPAATAIATTTSATNSSRQSDKSTPPVTSTPAAATPATKPARQSNKSALRKPSPPAGIRQVSTRTGPKPVLQKATTTRHASPYQQQQRQQTRRIALTPRVKAETGDHDDGDSVLDSSLPSIADTEQQEKHQQSHGVSVKRVVDFQGPASSEPSVERVAVSQAPASSKSPVKWVTDSQAPVSSKSPAGTVVSPSPSLRRPSSSSLDPLNLPKKFPPTDAPLGEISLLGVSNILIPVTMMELFFQRFDMLQDQLDELKALVSRDSASLGVSPAPTEGAATVDAEDLNTRVSALETQLIDNINASNKLFDVNKLLLDENSALRDELRETQQLLGDLHRGRRNPNSESGTGPDSQSASGGGLLTACSRVLGAGAVTEVAGVQASSSPQIAPISGVSLSDGGGSEGCEVIIHGLLKDSNKISKELSNGATLALLSTVLPSLSGGDIVGTRVLRPRGPGRGRGGDVIATNSGAKRSTLPTLMARLARPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0B5</accession>
    <name>A0A232F0B5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_013090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001411">
        <property type="protein sequence ID" value="OXU24065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0B5"/>
    <dbReference type="STRING" id="543379.A0A232F0B5"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="14532" checksum="3A3F582A4F5F8864" modified="2017-10-25" version="1">MHTLLTRGNAILAYTLSVSACLTFCCFLSTVFINYKTDVSLNTIKIVVKNVPDYSASREKNDLGFLTFDIQLHLTSLFNWNVKQLFIYLIAEYETAVNSINQVRKIKINAKPFIDFLGSFLHQSCQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0X1</accession>
    <name>A0A232F0X1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Smu-1 suppressor of mec-8 and unc-52 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSAR_009168</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Alberta</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="21">Component of the spliceosome B complex. Interacts with IK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001331">
        <property type="protein sequence ID" value="OXU24331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0X1"/>
    <dbReference type="STRING" id="543379.A0A232F0X1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032291">
        <property type="term" value="P:axon ensheathment in central nervous system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060857">
        <property type="term" value="P:establishment of glial blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007419">
        <property type="term" value="P:ventral cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003800">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000082">
        <property type="entry name" value="WD40 repeat-containing protein SMU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000289">
        <property type="entry name" value="WD40 repeat-containing protein SMU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 22" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0564">Palmitate</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 24" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="25">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="555"/>
            <end position="560"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="662"/>
            <end position="663"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="687"/>
            <end position="693"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="712"/>
            <end position="716"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="781"/>
            <end position="784"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OXU24331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="867" mass="97481" checksum="1258F477FF4E8E76" modified="2017-10-25" version="1">MSIEIESADVIRLIQQYLKESNLVKTLQTLQEETGVSLNTVDSVDGFVADINNGHWDTVLKAIQSLKLPDKKLIDLYEQVVLELIELRELGAARSLLRQTEPMVMMKQQEPERYIHLENLLARSYFDPREAYPDGSTKEKRRAYIATSLSGEVSVVPSSRLLALLGQALKWQQHQGLLPPGTTIDLFRGKAAVRDQEDEKYPTQLSKQIKFGTKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMEQAVLSMAFSRDSEMLAGGAQDGKIKIWKVQSGQCLRRFEKAHSKGVTCLQFSRDNSQVLSASFDATIRIHGLKSGKTLKEFRGHTSYVNEVIFSSDAHSIISASSDGTVKVWSLKSTECTGTYKSLGAADLTVNSVHSLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCAVVSPKGEYIYCVGEDFVLYCFSTTSGKLERTLNIHEKDVIGLAHHPHQNLLCSYSEDGLILHLLTKMGCAASANGEKAAAERSKKIDKGLRADGERIANEVKLLLLGAGESGKSTIVKQMKIIHETGYSQEECEQLKPVVYSNTIQSLMTIIRAMGSLQIDFEDPSKVNVARQFFTIASSTEEGELNDELVHLMKSLWKDGGVQTCLGRSREYQLNDSAAYYLNALDRITLPNYIPTQQDVLKTRIKTTGIVETRFSFKGLQFKMFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDLVLAEDEEMMRMIDSMKLFDSICNSKWFVETSIILFLNKKDIFAEKITRSPLTICFPEYTGPNTYEECASYIQMKFENLNKRKEQKQMYSHFTCATDTNNIQFVFDAVTDVIIQNNLSSCGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F120</accession>
    <name>A0A232F120_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001314">
        <property type="protein sequence ID" value="OXU24391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F120"/>
    <dbReference type="STRING" id="543379.A0A232F120"/>
    <dbReference type="OrthoDB" id="8193571at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="776" mass="89013" checksum="A3998A2B15AADA25" modified="2017-10-25" version="1">MARLSDFKEDDTWFDYDLLLAAFEREHKTIIRFLLKNNCRVQKKTRTEASTPLHYAVKISDIVIVKQLLKLKASILDKDENQQTPFDLAIKDKKYDIVDAMLSMYDFKTEHDNNEGKINCFHYVCKKDNFLAIQKFIDLGFPINSHAGPSIGYFFQGFTPLHFAVYNESLKSITYLLQCNASVTERNNQGDTPLNYAFYAQPKNDVIIDLLLQAIPKNALYADSRGLSHFHIACTRNDLSILQLYLEHENLVSLQIKSDEHIYSGYTPLHLAVEYNRFDLVKALLENGADVNTKTSKGETALHIACSHSSDKWYELIYDKDLDKEACDGIDWVSNRKSQIGIIQLLLNYKADINAKDNNNETPLIHACKISDDSILNHDQSFHMQKEHPLYQSMLKEINHRVLEIVKILLDNNADIHICSKQNYDSILHLIIKEKMEHSLELAKALLCKGFNLQTVDKNGYSPLHWATIRNHKELVKLFLDHNVDVNARSERLKTPLHFAVGHQTKHEPIVSHLLQNGAQVNVQDGMDFTPLHIAVDSSQNYQVIEQLLQYGADINLQDRDGHTAIEHFSLILGSDGTWDESFDILLLIENHVQKLIALGFFISEKIIQHLRYMNDLILENFDIDSVYPNDSLDLCKQELEKLKLFKIDGSIDLYSILLKNEEEMEKLVENENLVFTVASIDESNFVQYGCLLKLQLLKGIKRAILKKPALESLKFLGDFDQSKLCIDHISKHFNKEEDLSSLIRTGDVIVPSKRKCTDLLQSNKSPKKTDGNKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1E7</accession>
    <name>A0A232F1E7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_008383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001248">
        <property type="protein sequence ID" value="OXU24616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1E7"/>
    <dbReference type="OrthoDB" id="7696163at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="413" mass="47520" checksum="F732D09E6BA22E20" modified="2017-10-25" version="1">MDVFKIDQSLTAGLGSAPAPDTLTPEVSFDAGSEFNLSFFDGPEENSGQGFSDPGSIIRSVFEWQLEERNLEILVENFAGFLYFQGTLSKYYTSIYLEKKLLILYQRITYDWRGLQDDNEQAVLLRSWNIGRALTIFYIGYMFTACISFVTLPSVVPLMLDLILPLNESRGVNLCYYAEYFIDQQKYFIYLLLHTFICVSFTILIVTAVDSTFVSIVYHAIGLFNILEYRMRNILPFVEDYQNNKILSKEELHKYVVDSVKMHKKTIEFSRVYLLNKFSEIVQRIYNDCFFFVTVLVLICLSVGTIDLVINLNNPINLIRVGFVWLGIIMYTFFISWPGQKLINCSYDLFNTVYACGWYGCPTKTKYLIKFMMMRCTVPCRLTAGPLLTMDLVTSGNILRTALSYFTVVASFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1F0</accession>
    <name>A0A232F1F0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001273">
        <property type="protein sequence ID" value="OXU24541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1F0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="22" mass="2685" checksum="3C8A9992BD4910F8" modified="2017-10-25" version="1">MPCKIEPFKSRVLYKIYYSTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2G3</accession>
    <name>A0A232F2G3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001230">
        <property type="protein sequence ID" value="OXU24680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2G3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="5711" checksum="E2B6AB367ED37BF3" modified="2017-10-25" version="1" fragment="single">VKSFVLNFIAQTAKIRKSRLFVTKVVLICTVRLAHERNECDKHSAKKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F323</accession>
    <name>A0A232F323_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Osiris 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001166">
        <property type="protein sequence ID" value="OXU24919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F323"/>
    <dbReference type="STRING" id="543379.A0A232F323"/>
    <dbReference type="OrthoDB" id="8194491at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF1">
        <property type="entry name" value="FI01546P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011291981" description="Osiris 9" evidence="2">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26174" checksum="A9ABDC8D1B21CDA5" modified="2017-10-25" version="1">MLKFVVVCALAATCALAAPAQEQQQPSLFEQAYDVYSSCSAEADMAVCLKLKALGYVDRAARSAEIDVVDGFKIVQSEEAKSSRADNARSLNDIESSLPTEVEAREAAVDEALLDRTARFLSTHTVELSLPEEVSRSFGEARGKKKKIVKSLLPILLLLKLKAAALIPIALGGLALLAFKALIIGKIALIISAVIALQKLLGQKHQSYEVVAHEVPHHHDEHHGSGWARSLEMAYSAHKPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F339</accession>
    <name>A0A232F339_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001174">
        <property type="protein sequence ID" value="OXU24873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F339"/>
    <dbReference type="STRING" id="543379.A0A232F339"/>
    <dbReference type="OrthoDB" id="2150145at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF66">
        <property type="entry name" value="VWFA AND CACHE DOMAIN-CONTAINING PROTEIN CG16868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011968992" description="VWFA domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1202" mass="133134" checksum="6E3FD846C7E3C453" modified="2017-10-25" version="1">MTSYLVLCVAVLAIMSDCTAVMDEKLSNTVPKCQFGKSPRRQIDVMPLNGVCLRDMVVHLSKNLHKLTDDELGVTKFQGMLDKLEFVDSITTLNSRLNDLSKGFNDKLKRYTDLLRDSNSIIQPILLKQGQDIYSTSQRSDNSNRAADICSKITDALAMNLRNKDWKSLHILPVSQPGTMCGPPSLAHNIGPLLLSQCNRSKNVMLLLEQSSEFMSEEDVTLAQITAKTIVHMLTESDRVSVVGLAAGGSALCPEQGLSHVTDVHKIRLDRHVDSLVRSTVNQSFTLDLRPLVKEATGDLVLIHLTNNMKDLSNVKGIAEGLKRDNLTVHLRTILILSNQQPRVNVKEFSANGTVITLPTQHVLGYEIARLFAGLKCNKEDVKPYYLSEPYFEPYSKAMMLSVGQITNTALLSFDVKLRDFVEDITYFEVGAHQVRALLVDKRGTLWMHKNFPRMETIVEQPLKVYLHDLENLDEKTMIRTGMADQPEGMVEVKSQLGIKKQLHWRHLTYPDLIVCLVVSRLDEDATRQPLVRSPPTLPSGILHHRLDLALGANVRRDSLCTYNSNRIATLDAGVVYLSPWCFKSPAEQAKQLAAAPAVTVQSYMAYIKDLTRLLTNPGMQESVKADVAVLAQILEHFKERHSQSPLHKFIVQRYVTSVNSGVLELYPGLVLDSDLDPKRRVWYVKALEQPGRLVLSPPYLDAGGSGFVVSLSQVVHEGRSVGLHTSTDPVVAVMAMDVTMGYLSRMLNEMFPLCAETNVKCFLMDDKGYLVFHPSLLQAASKVENQHLTNKELLVANDILNHEFFVNKKMCASHMDGTTQRYYQFNISLDEVLTNIVHGEHCVKYQLAVVPGTNVFLGVVNITCSSISAFCPCSTMDRSCLNCKRMEQTDCECPCECSLYSSECQLREDSASAEMEPCPAPQEQGSSLTSPWIQTVNALKSCQPFSCKAFATKAECLGLVGCQWCEIDSDAETQLQEPFCSDVAVCFKGIFGSPIPYGDGAYNSQSPEEIMSREWPSVGPVAGGILAFVLVLGVALFCYRLRSVHTSLEHQCLHNHNSPDTLRMTHLDCDLEPTDLEREPKPSMDSALLRDVIAPISPYRVSTNYRRPPGGDSDHGYSTMTPHDDSEQQNFSEPLLVLAGNSKDICGVVPSTSTATLDSPATSTSTTGTIVAPPSPTTNLGSPHRVIAAVDVHRDMDTNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F342</accession>
    <name>A0A232F342_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001160">
        <property type="protein sequence ID" value="OXU24939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F342"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012963531" evidence="1">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="247" mass="27354" checksum="EDE5ECB1868A79A5" modified="2017-10-25" version="1">MSKATMCLAFLAAGLAVSLAKPADIVARVPSDYYYGTKWVLFRDDSIPDPPHNVIQAENGVQVLPTFRHQKQQQPQYQSYSYVSQAPVHVAQPVHVTAAPVHVQHSPVHVPLQLPVQPAHFRVQSSSFHVTPVPAHFQSHNFHVTQSPVHLVPAVHVTTSAPAHFDSEVVENSNLGGQRPQHQFGQNQVAQQQHQFDQQYQRKAQEIARKSPVVTKVSSFGVTAVPHGAVHVTSPAYFDYLRKKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3Q4</accession>
    <name>A0A232F3Q4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001056">
        <property type="protein sequence ID" value="OXU25315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3Q4"/>
    <dbReference type="STRING" id="543379.A0A232F3Q4"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="54"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="243"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="666" mass="77286" checksum="DB1D73B0CDF65592" modified="2017-10-25" version="1">MLGESDILDEEAQLPQDLEDDLVQEVLKTGTDLRQYSTQIEKELQEVENKSIQDYIKESENIASLHNQIAACDNILEQMESMLLGFQSDLGSISEEILYLQRKSITMSQQLTNRQVIRGPLNQFIEDMTVSESLIAGIMDSPVTEKEFVTNLETLNYKINFVKEQSFKDAKSCNDVKDILEKLKIKAMTKIRTYLLEQIYKFRKPMTNFQVPQNNMLKYKLFFEFILSNERNIAEEICGEYIDTMSKIYYSYFKSYCSRLKKLQFDESPSKDDLMGVEDTASRGLFHKSHLKHRGTVFSIGARGEVLSSQLESPIIVPHTAAKTKYHYEALFRSEQYALVDNGCREYLFLTEFFKVRGAQALDIFNQVMGKTISLLLKNLQSFVDDSYDAIALFLCLHLVMRYQLMCHKRAVPALDKYWDNMTSVIWPRFEYVFRLNIQSIKDCDPMKFSRETSPHYITRRYAEFSAAMIGVSEGFPCEGATQLLAELREAVQCFLLRMAAVFPQRTHQLVFLINNYDLVLGVLMERTRDNSKEAESFKEQLNARSAEYVEEILSPHFGGIIQLVKESEVLLEKGQMEDLKRQEGKALALVQSFTNNWKRALEEINRDVVRSFPSLLLGTSLVQRAMTQLVQYYHRFHKILPANVRPQLTNIHHIMVEIKKYKTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F434</accession>
    <name>A0A232F434_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001082">
        <property type="protein sequence ID" value="OXU25213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F434"/>
    <dbReference type="STRING" id="543379.A0A232F434"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000085">
        <property type="entry name" value="Glycogenin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="890"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="890"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1120"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1132" mass="123558" checksum="D3CE142B95758196" modified="2017-10-25" version="1">MAGFAWVTLATNDSYSLGALVLAHSLKRVGTQHDLAVLITPGVTESMREKLASVFNLVREVNVLDSKDEANLAVLQRPELGITFTKLHCWRLTQYEKCVFIDADALVVRNCDELFEREELSAAPDVGWPDCFNSGVFVFKPSQQTFASITSFAASQGSFDGADQGLLNMYFSDWAHKDISKHLPFIYNMCSTATYSYAPAFKQYGENVRIIHFIGATKPWLQYFDTLTGIVQPPPGCNHLQPLLQVWWNIFCDDVHRQLTDVMVASNMTTIWHESKSFSTYSSSYHHPPAPHCNPDEDSYNQINGPPDFSEFKDPWENYQERNDPFSNTNNQSSNDDKTHRCDTITHSTDQMLPDNQHHQTELTSPPSRSSDHGNSDRHDHVPSHSHENSQSKRQESFTPENQSSHSNACASASSELHNRTDEHVSDAKWLSENLEQINAVCECIEEFQNVIESLNEHSDHQDSRENRTDNHSQPSTSTTVNDSQNGRQNTNKAIKSNKSRTEKPHNSSKSSDTPRPYTNSHNVTTQSVLSASPSIENAEGGLAGALSKLTLGESRSDEQKAIEDHMRKQNWEQGHIDFMGRDSFDNILKKINETLASAPPRLPPPVEETQQPKKGTSKSSEVEAAVEGSEVALPVLATDDQAEGSSKIASQRIPSSEVTSPSLDHHEQPQVEASSVRTIDSEIASTICEQESTLTQGSIEPTEKLVPTTQLTEAKIEIAEPVKETREVTESIASKSSDTSRVTPLQTVAQDKPAEESTIGETPVQVVSEATTECPVPIQVAESVLQAEPKESVSEDPRLIVEAVVSSIIPPVQESAAAVSETLIEARPVTVPDAVPQPQQLNGHDPSLKLEDEIALPPTVTHVATASISPDVVSSVDNVVPNVPLETEQAVQAAQGSQPTQPQAHPNAPSAAEAQPEQSSQDVCQRSKLTVTLPSTDAAEETVIEKEDLSTSQSEAVATDESAECPVRPTRSKDLKIPGTPVVIGPTPPTSPPLDAEAVQTTEEGAQAVAKTETEVEKPVESQEEQPKKKMTKKSSSESDPPSSSETEGSSKKIVKKVKKVKEGEEGASGGDKPKKKIIKKVAKTSSTTSLEADKSVPETPPPAETSDVPVPPKRKSKSSGDEKHPGKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4G3</accession>
    <name>A0A232F4G3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000962">
        <property type="protein sequence ID" value="OXU25716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4G3"/>
    <dbReference type="STRING" id="543379.A0A232F4G3"/>
    <dbReference type="OrthoDB" id="5799458at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905">
        <property type="entry name" value="NINEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18905:SF13">
        <property type="entry name" value="NON-CENTROSOMAL MICROTUBULE ARRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="283"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="701"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="788"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1096" mass="126876" checksum="EE2270D899AED566" modified="2017-10-25" version="1">MEEEPSDPHEQQLYYVFKSCLTEGQNGLDKDGLLALCSKLELEESHRTAIVELLEIDTVNRSVSFYEFRDSFLALLGKSQEGLEKEVHGDSQALCKTFDHQRLQETWSNQNSLSIEDINGFCNGGSTLSKQSIELIFEKLDLDNDGFINRDEFLHFVQSASSKFHEQSRINWSTHPRRDQIKPDKDFVHHQTGHVLRSAIIELWEVAGIPEANSLLHELGFDAPTINLIDLSNALSSELKCHRDVSHAEGAGEYVRLLKGALALYQEEVRNLHTSMEHLCCERNKLRADIGEANDRANVLAQEIDEHQTRVDKARQEQIRQMEARHQEALKDITDQLNLERDKSSLTIKSLEEQLQASQQAEQRITAELSRVLQELKLLETENQNQSEEIGKLEISNSQLTKQVQELAAAHEQAESIETRENEQVSDLMSHIKRLQAEMKVLRDHNDELTSELEVLKHRDNDVKSIVSSIEIRSTISDENDGLISMPTTEISDTEDEDKHHQKYSDHSRTIKVINVTRSKPSVDEQSSNGNSINKLTEIIQEFRNFLTGAKFCVECAVIRTEVSSLISELELYQSSVPANQATLATNNKKKQLRNLANELEAECKSSSRINESSSCRDLVMPRNDRFKNCRRISSSDDMIHDMDENFDVITIKAAPKNKLSGLRDYPPRKESEKTGKKGVINNLYFKKCNVEVKDPLKEEEARHAAEKKQLQERVSDLEKSLEMLKAEYEQCEDYWCTKLEEERQIFEQEQKISDEKFSELIVKMAEYEEQFNPSGKHDGRLSPIEERFSLEQQYNDLEDEFEQWRNEAQEELSKKTKEIEELKAKLSSEKRLSLADISVQFPEEPMKDMYPTLYNQLCSPGGSTENTTPKTSSTVPMEANSCTMQQCVQCHKLTTQPSCDCHANTHQNLPQQHYEGQKSRRSEGKSRHHHHHYHKKMEVDYEFTNLIKQKEKLKQEIMKLQNLKTMNANHIYPMIAPEHQTIFSNLCAKLYAQEQKQKYMQVYYQTQQKNSEQYLQEIYKQHLLDMSNLQFVIKATEDKLNRQIKLNQEQKDKLTKNDFLTKELYVENAQLTETIKRLEQHCQILTQNRIETTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4R1</accession>
    <name>A0A232F4R1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_012043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001022">
        <property type="protein sequence ID" value="OXU25453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4R1"/>
    <dbReference type="STRING" id="543379.A0A232F4R1"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040221">
        <property type="entry name" value="CDCA7/CDA7L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169">
        <property type="entry name" value="OS05G0300700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169:SF8">
        <property type="entry name" value="ZINC-FINGER DOMAIN OF MONOAMINE-OXIDASE A REPRESSOR R1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Zinc-finger" evidence="11">
        <location>
            <begin position="203"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="307" mass="35223" checksum="71E4E19AAFB6FC57" modified="2017-10-25" version="1">MCDTEDYEALRLKNIAERNAFLQDFLKDIKEDAEEIKQLENTRLSIVQKENRPPRTPRSVTRRRRSSANKSPTFTGPVRLEFRKKYNTRSKKRKLEEGENDEEDDELKSDQDIIVPKSRSNLKVMFPWSRPLQRDLDLMKFDFSEEEDNDSEESDEELYAPTKRKRMQRVTKSAYDPSAIPSPDEITPRMLNNIAQKASGKVYDAVNGSSCHQCRQKTKDTKTVCRSGECIGVRGQFCGPCLRGRYGESALEALQNPHWACPPCRGLCNCSICRTRNGQRPTGILAPLAKEEGFESVKDYLQANDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F503</accession>
    <name>A0A232F503_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000952">
        <property type="protein sequence ID" value="OXU25755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F503"/>
    <dbReference type="STRING" id="543379.A0A232F503"/>
    <dbReference type="OrthoDB" id="43580at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8005" checksum="382AE313F24AE324" modified="2017-10-25" version="1">MVDLGGYIIILMNHSGKMKLYGSPADSTDSLEIGDEILEVNGRTLENATHSEVIQHIHQVALHSSALSANESMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5V1</accession>
    <name>A0A232F5V1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein CDV3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDV3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000957">
        <property type="protein sequence ID" value="OXU25737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5V1"/>
    <dbReference type="STRING" id="543379.A0A232F5V1"/>
    <dbReference type="OrthoDB" id="6288097at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026806">
        <property type="entry name" value="CDV3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16284:SF13">
        <property type="entry name" value="PROTEIN CDV3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15359">
        <property type="entry name" value="CDV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28507" checksum="F2458392D9D11916" modified="2017-10-25" version="1">MADADLDDFFAKKDRKKAKGKKFTTTEEIAKKLEEKKIEKPKPKEKPVNPEGGDEIQQVEEEEEEWKEFEEEKKDYTGLKIGNLNVVEKVDKNYDDERNAGETGSDGESGDGDGKHSGPWKKADAPSQAAEPEPQPPRPQPVAAPAPAAGTGSSSYRPPHVRNPPPSYDRERPIGRPRGKNIAPDINSEEYFPTLNSKQPANEATGAWGRKKRDEGTFEEVRNRGGTYRTYSTPETQSQAPKLSLGNKYGALPQDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7M3</accession>
    <name>A0A232F7M3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dpy-30 histone methyltransferase complex regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_012032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000798">
        <property type="protein sequence ID" value="OXU26448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7M3"/>
    <dbReference type="STRING" id="543379.A0A232F7M3"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000003">
        <property type="entry name" value="protein dpy-30 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16034" checksum="27ADE1AD19C85A72" modified="2017-10-25" version="1" fragment="single">LRNGVNWWYVFAYECFQLSLLLPIIPFTKSSAFIFYFSLETTADDRSETISAASITNVLPDATQKSIIMDKDADLASAPAKKTRVEVQSLPARQYLDQTVVPILLQALSSLAKERPPDPINYLASYLLRNKSQFDTGGSPPTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7N8</accession>
    <name>A0A232F7N8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000787">
        <property type="protein sequence ID" value="OXU26510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7N8"/>
    <dbReference type="STRING" id="543379.A0A232F7N8"/>
    <dbReference type="OrthoDB" id="7609731at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="135" mass="15105" checksum="52A07E6D9FBA96A1" modified="2017-10-25" version="1">MAEGSAEEEQSSTAAPASPPADLRILNTQLSTSYQQQQQQHYQQQQQQQLQHQQQQQSRPQQSTLLQQRQHPNMLATAVPPRHSMLPQPLKAEIKSENELDNSCDVPLNLKSEVSCPRNIGRLARARGSAALRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8X9</accession>
    <name>A0A232F8X9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000692">
        <property type="protein sequence ID" value="OXU26950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8X9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="6956" checksum="9801E5318DDF5610" modified="2017-10-25" version="1">MHALIHDSIYIQHCVLTDFVLFKCNYCVKSAIDALEVTNDEVCTGISISSVCDLSHCQPPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9N2</accession>
    <name>A0A232F9N2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000614">
        <property type="protein sequence ID" value="OXU27385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9N2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kazal-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8548" checksum="AFC2224D5BAB917B" modified="2017-10-25" version="1">MTNQYSISNKMNKQLVFVFFIVMIAMAFGCICPRNYQPVCDNLGKQHNNLCLFNCASEQAMRNGQELTIAKYGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA30</accession>
    <name>A0A232FA30_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_007290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CIBAR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000623">
        <property type="protein sequence ID" value="OXU27330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA30"/>
    <dbReference type="STRING" id="543379.A0A232FA30"/>
    <dbReference type="OrthoDB" id="60621at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07598">
        <property type="entry name" value="BAR_FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035590">
        <property type="entry name" value="BAR_CBAR1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF2">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06730">
        <property type="entry name" value="FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="9">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="11">
        <location>
            <begin position="6"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="9">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="9">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="9">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="9">
        <location>
            <begin position="217"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="9">
        <location>
            <begin position="270"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="647"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU27330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="713" mass="78875" checksum="17B5B0C7A2C014BD" modified="2017-10-25" version="1">MDRLALYSWGANSHGQLGLGDIKEDEVLAPRKVRVFPSAMRLDEVIKMVGGAGHTLFLDQRGQVFSCGWNDKGQAGVPTCSSTFQKVEALRNERIADVACGWDSSMALTRDGDVFVWGSNSHGQLGLRDVAKVSEPRKLVGEVDGRKFQRISMGLRHSAIVSTDGELLVSGASNKGQLGVDLRGARCSESFLTVSDLPPVREVACGQHHTVAISRDNQLFAWGDNKHGQLGIDPRKGKIVTTAAKVENGSEVNNTSGIYCGWTHTCLYSSVVYSWGRNSYGQLARPKDTPVSECWKAGVALNDDLRSLSVGSEHNVALTGSSGAVLTWGWNEHGNCGTGSTQDVFRPTDVKLPAASLIGTVFQFSVPQKYILKRTLYYNTRIHTQVHRPSGLSRGSGDSEREAKFVQERIDAVEKHLAELCSVFAAYTRKAARLRDKNDEVAKTIQSYADAEDINRSMSTCLVNFANTLSVVGDYSDAQVQRLNSKVVAPLSQYQNTCKRAKENVKSTFAARDEELKRKRMLEKVREENPKNQQRISQAKSNLMKATVEVSRVVKGLEEQIDSFEKQKLHDIKTILLSFVTVQLSFHAKAVELLTKAYQDVAEIDEARDLEAREFRETMKATESSTKLSAVKKSGFRQAYSLMNLHNRFSPSPSSLRKGKAHRTTESLDSSKTGHTNSSESVQVEEYDESTDDSEESSSIREKKSVRSRLKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA32</accession>
    <name>A0A232FA32_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000553">
        <property type="protein sequence ID" value="OXU27706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA32"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="255" mass="29690" checksum="A1E2F35760750A57" modified="2017-10-25" version="1">MREKLHNAGILIPKSTEKVADKKEHVQLNLDILFEPEVKDKELLRTVWKASYDYRHKVHYKDNRFYDIIEKFSVLKTDVGSELILFQFAENLKVEDRVVKNWTSISAKIIKYAKSKVIAAQNNKKTQKAKSKNEEKSDTIEENSISNQETPDTFQYALDYSKLASSLDENNFSTNIDYQHALAFLLLPSLINYSFSAKKREWRPQQSDICKWFIEHVQEADDERIQEFVAGKIDELETINNVTSVQSYIIFSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA36</accession>
    <name>A0A232FA36_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000553">
        <property type="protein sequence ID" value="OXU27714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA36"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9542" checksum="47E05610B3B2117D" modified="2017-10-25" version="1">MKLRLPESPVATFGVAQKQNAVNEQGSVGTFRDYVGLRLWLPDSPVVSTRGYSGWCYFVLSIWDKIKIFIFDLMENHPYISSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAJ2</accession>
    <name>A0A232FAJ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000600">
        <property type="protein sequence ID" value="OXU27458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAJ2"/>
    <dbReference type="STRING" id="543379.A0A232FAJ2"/>
    <dbReference type="OrthoDB" id="5969782at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01272">
        <property type="entry name" value="PTB1_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000034">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000317">
        <property type="entry name" value="Amyloid beta A4 protein-binding family B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="159"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="379"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60641" checksum="9784647D3A0E0B0F" modified="2017-10-25" version="1">MGGVPHVEGVNNDLYANVPVKRRQHKDKLQQQLQNNVENPDKNDENSVDSEDKDENLPPGWEKHEDKDGPYYWHIKSGTIQREPPEARISKLESRKSFVKDNDSINNFNSLGGLVNTVTRSNTSSALDQELENKRREELALKRRSYPARADSEDRNKPIRFAVRSLGWTEIAEEDLTPERSSKAVNKCIVDLSLGRNDLLDVVGRWGDGKDLFMDLDEGALKLIDPENLTVLNTQPIHTLRVWGVGRDHGRDFAYVARDRSTRKHMCHVFRCDIPARTIANTLRDICKKIMIERSLHQNLAKPVDINGRTSLAARPTNLPTEHRRFHRNGQALVSQYPVQYTVALKLTACEYFVSDYICSVGTPAQSFPTPMEEPKKVLRAQYLGSMQVSQATGMEILNDAIDQLVGNTPINQWRNVNVAIAPSMISILTPNDDKLIAECRVRYLSFLGIGQNVKQCAFIMHTAQDLFIAHVFNCEPSSGALCKTIEAACKLRYQKCLDAHPPGFRNASSVNTPSGRGLGATLKSFVGSLTGRKNKQNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBE4</accession>
    <name>A0A232FBE4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000470">
        <property type="protein sequence ID" value="OXU28154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBE4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012036928" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8203" checksum="459A621A42984E6D" modified="2017-10-25" version="1">MKFAIVFCVLALVVALVTAKPAENTTPKWDLETCEERAVIARRESNRCEDYQCIMHSHGLVLDGVNCKDHPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBX1</accession>
    <name>A0A232FBX1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_002629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000475">
        <property type="protein sequence ID" value="OXU28122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FBX1"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="8">
        <location>
            <begin position="1767"/>
            <end position="1931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2065" mass="235670" checksum="A952562D4A3DBADE" modified="2017-10-25" version="1">MATTDLAEQLKRLRTPQTTLLLQDTRKPSLLFDVKEAANLDRDTVYNIGLSGLEELTKLCGKFDEFKKTLFAPSSISLERSVQDNKVNKNLDSEIDKFLVLLSPYFLLNISHKALEWLIHRFHIHQFNKDNYLLLILPYHETKIFVRALQLLDLSDPADKWHWLKPIQKTRTPLPPLTLVNRVAHDNGFLKLICAHVIFATKIYGDRANSLNTLYAFFTTALVGTVESSASITDVQFNHMLPVLLKGLPSQIPDFASSSYVIFAKLITRIKIQDETMDKLVLKSIKKPISTQEVMALILFLYDNPFNSLSVVSESLMLKFSNRPWFVDTMIKVKSHGVNISKFVILLLESAFSYISKNAGSSESEDVKEMLEDIFNRIPLEEDEVRLILEKTLANDAVSGENSDITKEYLGSLYQSIERKYPDSFDRYLHELMHLKEANEHTNKILKFLMSWYSKAEECLDIFTGLNHNNPEQRIIAIQMIGKNLTIPDNLRELVNKSLLTRFNDDDDRVIMALLNLPINLLQNTFAVDTLVDELIILVSRCHTGEKRMLAKPALKVLLELCDETDDTSVFLVIVPYLFPTADEDVDIAIQILTSGFARRNAFLKKIAQEIGNETNAEFIRMAAFHIIMTPEVLPPAINILTAIKQQMTHGDAASVFFNLVVLGSVCRVPVGSLQLDIARQVIETASEMVNNFPKVLPLTGANHLNADNFLDALKYVSQGYLPLQANTYVLEMVHRRLQLNITSKFNFEEDPERSELMLRLLEIIFDGIVLEQWRSNYSQWELHHQWYLKIFFKRHFKNEEEVIRFLSQLYIKPVKPQTSLHCLEISLLLLDKCNSFQWAFNDRDFVINLLLALSSENNVCREAAVNILKKLSQTFNISMEGFSALLSELMDRNTEISLDHDQLSLSLYTLLSPDPDVTYQLKAELRVKLEKTRDLLFEAVLSNEVPIHVRSQLLDILIHVNGPKILKKLIPLGTELLNKIDERDTFAQNALKNIIQRFDNSSVAAVKDKHVWSFFINCLSTHNKYISTESGKQFINVILLKQIDNNFFVSLGEISQNLQKEFLAKLVDIVTDCEIDSILSTTTRVVKKLHIDAQLVVDELKMMTDLEEETSESNRNRASLRKKRSISRISNRYNPEIVHSRKWKRGITLLEFLQHSNNIENEQLLVPVLFDLLKTSLCFEEQSPVEYTNQLVLSTIHHLITKSIPVKDADAYVDLISQCIRTSHNPQTHHHALLVLVELFKLADIQRALQNIMPIFTFMGNTVLRQDDAYSIQIISKTIDTVVPIINAANNVNHVCEILRLFITSLPDIPEHRRVPLFVKLLQLLDNHLHLYYLLTFESHVLSKNVEPSSSSELSSERLRFALSISNKFPVKKVIEVCVKFVEFLKELPVDIDENQKHNIKFKSNHIFDVANNSPKQLRHYKFTIVRFLVSLLSGSDFINRVAELDEDDVEILRPIYDQLIVELVIYIQNTSRNADLHQGKPNGKYWKVMLHGLYDILDLVNNLLPNQIFIASAARLIDHDSLTVRRKALELLNARLAQKKFTDEDHEDLLGLIEPITSVLSGPHKFVNPEVEVIQQTALITLKLLAKVLASKRPDVFKPILDLATELVKKREGAVLGSAALCVAELCSSMRVHAIQSLNKFVPAIIRLLEKHCHQEIPDILTISIVSALQKIVESVGNFLSLYLDQLLYELSRLNFLYTDSEHPKIGLVVSRLKATTQKLSSCIPLRVLLPAINKTYDTLLTNKSYQCIPPLMNIIAESFGSVQSSALSSAIPDLATFFLKVLQFREEVTVSKGEMEVDGEATLNDVTNVEESASKALVALVLKLSEATFRPLYYRLYDWAARNPQHKQRNITFYRLSANIAECLKSLFVLFAGHFLKHAASLLTGNNMINANEETLEITLEDEASKIELIEEILLTLLRVFTYDAHDFVNQERFETLMQPIVDQLENTIGTKVEYEKRAKNFIVPCIASFAGAIPDDSLHKQLVYQVLLKTRHTKPYVRNAALDSLVEIARKLGEDFMPLLPETVPFLAELLEDEDLVTEKNAQNAVRTLEDILGEPLQKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCG0</accession>
    <name>A0A232FCG0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000468">
        <property type="protein sequence ID" value="OXU28163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCG0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="224" mass="25138" checksum="2170880063E630A7" modified="2017-10-25" version="1">MQGDHLTVQKNTIRKTIEYAEGRTNVHRPIITGPEMAMEKLGKIEEKSTSLLKGPELRLEEESLGTRPRNQESLASIVSARSIDSNSSKKQIMNKESRYVNLDTTGTRVLEVKQTRSGDILLKQGRGSDRTAFTVGVERAILGLGQVKKEERKATLEIGDMDSKATKEEIRAAIERALRKPDNGRRVTLLRSNTRGLRMTIVILRKREAEVLLEIGHIRGPCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCW0</accession>
    <name>A0A232FCW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000445">
        <property type="protein sequence ID" value="OXU28330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCW0"/>
    <dbReference type="STRING" id="543379.A0A232FCW0"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF12">
        <property type="entry name" value="FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="701"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="811" mass="91608" checksum="39B9A81D901B47EF" modified="2017-10-25" version="1">MISGLQIALKNAIDVIAPPATPLQDFTYHWKQLMNFYVNHLSDSKVPVETTSIPKHLDRLLELLLEEEKHGDEPGPCLEYLLQHRLLDLLATLASAETPPGMRLVCLSFLRRLLTRSKHPLLHHAAVYGPVQRLIAMCNGNLASPIENEEIQFLLCLCFLVCKYPHVTNIVNDSSNVRQESGILHCDYEKSEIEKVTYIPARKMNNANPLFKPLNTQAITLVNPDLFQTSRNHSFHNDSVDKSIAQSEDSQENKPSKHIRDTSTRSNSSTQSSRSSRDVEIASRTSSPLTQKPNENIPNSVSEISDDTQETEHLYKVPEQVESSTYDPVIAALNDFKDLRISEEYASSNGDIKSRSSKHDITLSGPGSPEHSKCLLLDSLKSYVNSADNTIRIRACEGIMVLASLDDPFFAEIVAKSNLSAVLAKRLEVLFNLIPAHVEPGEIEDIEVTWGLDSPPLLNEKKFPGCRRVAAFFMWLDFCAQLSREAHPDVAEVLAQNIRINFFEKVLTPALSAHHAVLITALITKCLKDIPSSPLSTEIGRWLVGQQRDPDIPDVWCSPVIHRLIDNCCTKSDDLTTETLKLFEEMIEKKDEHILHCLVLTYLNTRGYYDNSAADSAIASWSDEEDEREREKKGSMDISHGTSHSRTLAPSNIHRILNWYCEIDFVIHSSFLSLVPRQLQTESDNNYGRYMGDWEKQYSMVLALLPHPYLHEFLLNPLIPLTPGKKSLFICLQRVVKQLMNEVPKIPSYKQALKETRLRLFDDCCQIDDSTVSESSARSKEEEILLESAVVTEEFCKELAAIAYVKYHHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDS6</accession>
    <name>A0A232FDS6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000372">
        <property type="protein sequence ID" value="OXU28825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDS6"/>
    <dbReference type="OrthoDB" id="6585706at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="131" mass="14669" checksum="797CFA1610E2F10F" modified="2017-10-25" version="1">MKGHTCSPEATAHRRLNKTIKNPTSNRQPVPAMIGELSSNGESLDDMSESVDELRQKLANMKRLMEERKGTTLGEISARKQRHQTANIIDGTFLSWIFGTALAAIVSVSFYAFFNLFQAVRKKFPSSHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDZ2</accession>
    <name>A0A232FDZ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Guanine deaminase</fullName>
            <shortName evidence="9">Guanase</shortName>
            <ecNumber evidence="3 9">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 9"/>
    <dbReference type="EMBL" id="NNAY01000364">
        <property type="protein sequence ID" value="OXU28872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDZ2"/>
    <dbReference type="STRING" id="543379.A0A232FDZ2"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="59"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="430" mass="47509" checksum="87AF7CD2C785D2B1" modified="2017-10-25" version="1">MGVQSIIGPIIHCDDSGDLVIHENVQIDIRDGKIENVHLNPDTNNVHKSNVKRLENGQFLIPGLIDGHIHAVQLPNLGLGYDKPLLDWLSTYTFPLEKKYEDAKFADRVFDAVVKRTLKMGTTTACYYASLHGKASLILAEKAAIHGQRALVGKVNMNNCPAEDYCESSQDASIQDTEKFIEEVDNINNPLVRPIITPRFALSCSLELMKNLAELARTKNLHVQTHISENKEEIQAVKDIFPEFSSYAEVYDAAGLLTKKTVLAHGIYLSDNELNIIHDRKSAVIHCPSSNTCLKSGLCDVRRLQAANVKVGLGTDVSGGNLPSILDVMRAALQVSTHLSLEKPGYDPLNYKDVFYLGTLGGAEALDMNDKVGNFKPGKEFDALVIDLAAPNSVLDNLQEYTLDEKLQRLIYSGDDRNVVEVYVSGHRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEA8</accession>
    <name>A0A232FEA8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_004273</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000337">
        <property type="protein sequence ID" value="OXU29106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEA8"/>
    <dbReference type="STRING" id="543379.A0A232FEA8"/>
    <dbReference type="OrthoDB" id="10050276at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF10">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012421022" description="GDP-fucose protein O-fucosyltransferase 1" evidence="17">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU29106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="383" mass="44022" checksum="80444DDEB65E520E" modified="2017-10-25" version="1">MLKFLVFYFFIIMIDDMLCIHEDFDISGYIAYCPCMGRFGNQADHFLGALGFAKALNRTLVLPPWVEYRTGEIKSIQVPFDTYFNVSEIQKCHRAILMADFMRNIAPIHWPPSERISFCYAARGQTESCNAKDGNPFGPFWDTFNVDFVDSEFYGPFHYDVHHTDMAFQWRQKYTSAKWPVLAFTGAPASFPVQLENKKLQKCLVWNDDMNARAKAFIKTTLPRGAFVGIHLRNGVDWVRACEFISTSPNLFAAPQCLGYRNERGKATKTMCLPSFEVIVRHLKRVIRNGKDIKSVFVASDNNYMIPELTKALERMDIKVFKQEGNSPHLDLAILGRANYFIGNCISSFSAFVAREREVKGYPTYFWGFPPERTLSSMTHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF74</accession>
    <name>A0A232FF74_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000294">
        <property type="protein sequence ID" value="OXU29411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF74"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="24" mass="3063" checksum="EB4C6C342F306333" modified="2017-10-25" version="1">MQPFLSHFDFKAKFTILWTIYIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHM4</accession>
    <name>A0A232FHM4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000187">
        <property type="protein sequence ID" value="OXU30175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHM4"/>
    <dbReference type="STRING" id="543379.A0A232FHM4"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="303" mass="31973" checksum="188A68CC64A05CC6" modified="2017-10-25" version="1">MSMKKESPWDVELHLAAARGDAKRLQVLLDSGRVHVDCKDKDGTTPLILAAAGGHIDAVVELLQQGADANAKRLTGTTALFFSAQGGYMDIATILIKHGAVVDSCSIDGGTPLFVACQCGHLDVVEGLIAKGANVNAHMKDGATALFIAAQNGHVRILEVLLAYGAKTESARTDGATPLWIAAQMGHDHVVRRLLKAGAKVDSKRHDGATPLFKAAHKGHTAVIGEILKYRPNLGILPNGESALHAAALMGHMTVARQLVGAGADPLLVNQEGLTPLQIAIRHSQNQVANYLKDKIRSRTAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHQ0</accession>
    <name>A0A232FHQ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000228">
        <property type="protein sequence ID" value="OXU29867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHQ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="25393" checksum="44330C31FBDAD08C" modified="2017-10-25" version="1" fragment="single">SRISENRHRENVNLAEARPQRRSPGFIIREVNVFREAAAGKQLSDVITCTSLRYLYCVYVPVRAFLKNFAFFTRGTTQQEESASVSFSPGGQRKSVKIKLKLIGRRTAGGPGGGGGCAATALMGNNSEPSALEGNEEIIKLDVSTEGLYDSSSSVSSDSAASQGSRVSHDFLANIGTSYVPSGSTYKAPSSRAFTGVCLFVCVRVRGTQWSVSRDTDRDDESPCESLTSLDADRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHT3</accession>
    <name>A0A232FHT3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000192">
        <property type="protein sequence ID" value="OXU30123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHT3"/>
    <dbReference type="STRING" id="543379.A0A232FHT3"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010349">
        <property type="term" value="F:L-galactose dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19163">
        <property type="entry name" value="AKR_galDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000011">
        <property type="entry name" value="Aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044479">
        <property type="entry name" value="LGALDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="369" mass="42107" checksum="A8BA9B3DB24F0570" modified="2017-10-25" version="1">MSGVSWERNKELPPTFVEGFHDLQDVKAMEYRILGKTGLMVSKLSLGGGTLGCHYADFDEDEAIETIRKAIKKGINYIDTAYWYGQGKSELIIGKALKGIPRQAYYIGTKVGRYELDFENMFDFSPEKVRQSVKQSLERLQLDYVDVIQIHDIEFAPSLDIIITQTLPELSRQVVEGRARHIGITGYPISVLKECIEKGNINIAVVLTYARFTLIDDTLLEYIPFFKERNIGIINAAAPSMGLLTSQGPQKWHPASDDVKKVCKEAGDYCKEKDLEFTKLAVWHSLQCPDVDTHLIGMQNLRELDINMDVLHNGITEEEKKILKDLSESKALIDLGDMNNFDKDMYLSKLTTKHWEGAELEKYWKEMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI87</accession>
    <name>A0A232FI87_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000207">
        <property type="protein sequence ID" value="OXU30027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI87"/>
    <dbReference type="STRING" id="543379.A0A232FI87"/>
    <dbReference type="OrthoDB" id="10055432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41153">
        <property type="entry name" value="RE41427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41153:SF2">
        <property type="entry name" value="RE41427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280181" description="Spaetzle domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26344" checksum="951CA6E959CD352C" modified="2017-10-25" version="1">MTRIAVFGMTGRLLRLALPLLLLLLASSTRAAKRCEGSGSGLKYVWGDALKDSMDCLGPNNMQYPSAAIARNLKSVWGGNSRTARHYQQPRTIDPELTRQALLNNYRAAQGDYSIAGSSRSARSFSAKDTCGSPSRLCKTRYNTTAPMYGVSLTSGQPVTIVQKFPDLLQQVVFEVCESKECDIVHGECTQTYVPYLFLVIPLGPVTLTGQDYVLVESGCVCKPKNSLNSSGSATDVLSVPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIK2</accession>
    <name>A0A232FIK2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIK2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218131" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="9980" checksum="19B684F6C7848C3F" modified="2017-10-25" version="1">MFGNKYLLILLLVCISLYIVLADDTGSKAAGGGSNPEIIHKNTINIYGNKSSFATRGFLRAQNTNIATTMLLEVPSARVNSINVIFWSFVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIM6</accession>
    <name>A0A232FIM6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000152">
        <property type="protein sequence ID" value="OXU30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIM6"/>
    <dbReference type="STRING" id="543379.A0A232FIM6"/>
    <dbReference type="OrthoDB" id="7554397at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="458" mass="51783" checksum="88C00963358D4B93" modified="2017-10-25" version="1">MSSAKPTTVAPSAGMQVGKWAANQEDLLRGLSAPGVDCKDTIIQEQEAVSALGLRWLAKEDAFCFSIEVSEVPSATTVTNRSILATTAKLFDPVGWLSPIIVRAKILIQKLWLQKLDWDDSVPEVTSRSWMEFITQLKELEAIKIPRWIGTYQKSEWLLHGFCHASERAYTCAIYAIMPNQVGHSVKLLATKSKVAPIKVLELCGAVILSRLAAYILSKVKRKPSQQHFWSDSKVVLAWLQAHLSKWKPFIGNRVSEIMTSLPDSVWHHVKSADNPTDLATRGVSLAQLQNSRLWWKGPAWLSQPADDWPCKAEPLKTTLEARNADKILGFTALVPAELTTWRYEFKKKSSFSFYLPNKVVDLEDQTGKCRSAQFQYGEYSLKTGQKIANVYTRYRIFFQSRSASFNISMTQHLRTGSHVSDDEIRQAEEKFAESLHLAQMGMFNLLENDLFFTYSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIZ5</accession>
    <name>A0A232FIZ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="19">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSAR_016679</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Alberta</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="19"/>
    <dbReference type="EMBL" id="NNAY01000158">
        <property type="protein sequence ID" value="OXU30449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIZ5"/>
    <dbReference type="STRING" id="543379.A0A232FIZ5"/>
    <dbReference type="OrthoDB" id="10005095at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07459">
        <property type="entry name" value="CRD_TK_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05048">
        <property type="entry name" value="PTKc_Ror"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000116">
        <property type="entry name" value="inactive tyrosine-protein kinase transmembrane receptor ROR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041775">
        <property type="entry name" value="Ror-like_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 17" id="KW-0420">Kringle</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 19" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="23">
        <location>
            <begin position="351"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="24">
        <location>
            <begin position="580"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="762"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1054"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1054"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1077"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="26">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OXU30449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1231" mass="138330" checksum="164CC67B46AED054" modified="2017-10-25" version="1" fragment="single">TDVDAPAGGKGGTLKFIRALTNLTKDAGSVVHMKCEIVGDPPPTKIRWYKNEAPVKEEPNRVIIKKINPQNHEHAAKNIAGSRLKITRLDVNDRGFYSCRANNDKDFIQSEGTLQVRTSRHAGRKAISLDNRNLLRPNRKYIFHEGCKLIIFKTNDDKKFIKSRISRDKNASTAFDAFYAVLLCQAFQRILRATSYSLSVKSTLIYDLRKTKGARAQVFSSAREKGLRHSALYVYTANLLAYLVLTLNCCIFVRARMSVRSSYSDDDFDDASNNDGNKFGTSGSGVSTPNQLGSTNHFGISPPSPQPTNSQTSTMDLMEISGLKNVNMQIPVGVSLANLPGASLLPGRKDNHEGICELYEGKICAQFVGNHSVYIPHPLTQKMLEEKLIKAFHVINQSNDLSSNCERYAQPSLCYSTFPICRDFPKSQKPSTQLFKLLNSNQQDSFDDTDIDDSFDDLSRLQHGIRRKRGGKYRSNFDSSIDNKERASTRKIISTTYGDSRSAKKVSLNRKLRRICRKECEILENDLCRKEYAIAKRHPEIGKQVPLVECSDLPEEGTLEAADCISIGISTENNVQENVYCYWGTGKSYTGPVKTSMFGRPCLPWKNQFNLQISDHLELAGGHSYCRNPGSTEPQPWCYVDVDNRSQKEYCNIPKCVENLWVYAVVGFVLTGGFVIILVCYCCCYKSRKSRRQTNHLPTNKMLNGLQCDKNIYDGRRNTTQPMEMSSLLAGPGNTTPGTGTLSSGSSRTSNNRVPQFTINNVMLLQELGEGAFGKVYKGELQTGNKADEVIYVAVKTLKENASPKTQSDFKREVDLMTDLRHPNIICLLGVILNGEPMCMLFEYMTQGDLHEFLICHSPRSDVPLNNASGKVLEQPEFLHIALQIASGMEYLASHHYVHRDLAARNCLVGENLTVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPPESILYGKFTTESDVWSFGVVLWEIYSYGLQPYYGYNNQEVIDMIRSRQLLPCPEDCPTMIYSLMIECWHEVANRRPQFPEIHHRLHNWYVNQTYLSDFCNESITSYSGSSHKSTNKTNSTQLSAPVYKSDSLTRNQQTQLGMNKQQSQHVPDSQQTLYGGVTTDQQSNILKILSPNFHSSPQQQQQQIFANGHSCNAYGDQQQGTPLKNHLGYPNQNANMGLIGEDKQQCCSPKLSGAKKVLPAMVIPHQQQLHKNGGVQNGAQLVVRLPDPSKVLTETRLSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ62</accession>
    <name>A0A232FJ62_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ62"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="22602" checksum="BAB53105C916ED2A" modified="2017-10-25" version="1">MSLFSVKLQETTLILSILGTRYIGERCRHDIRVLQPRKLPSHKFRLIFVFSDPKKTPSNEFLVAMLQFSVKLSETTLILPTLGTRYLGERCRRYIRVHQPRKPSSNKFRLIMFQILTKLQETTLILSTLGTRMHHYLKFQSNRQCGFIVVVNTFESVPLGSQKKIVTSYINLAHTIIVGPSHVQINTIQYRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ92</accession>
    <name>A0A232FJ92_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000124">
        <property type="protein sequence ID" value="OXU30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ92"/>
    <dbReference type="STRING" id="543379.A0A232FJ92"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="584" mass="66617" checksum="1EBCEF61EFEC6449" modified="2017-10-25" version="1">MSPLNRGPFMGPRIPPTAMRPPMHRYGRAPPLPPGMARGMLPPPMNPMFGPPRGRPMPPMPLRPGPMMARPGPLPPCPPCPPMFGPRNRHMPPMPPMPPMGLRGPMGMRPGPRGMLPPHALPHMRPRFPPNHTNGKAKPNNNTKKANKLEEIELKKPWMTDEIRSEIQKKNKLYAKAKKNKDAKEWEEFKDLRNKVTRMIRDAKNEFLAKNPEQAHLYGNDEEIPEVTSEDVTEFFAMGSEDEESATPYCEVCDRDFDSEEKLQRHIQEHQICRIDGCTFTAHPKIVEKHISMQHVTGLYERMKNVISDKDVTKWRAERKRRYPTAVTIKILEDEQIAKKKRGEVIQNEIESRKIQNTPKREKRKPRKRKRNKPAQSRMTEKTVECELYRGLLPFAGTAMLDENEHSDDSLVHDAIEVEVVEPEEEKCKIVLSEEDEDAVQQIVISDEDEGAVQQIVPADVKKPEIAESPRPVVPASLTLSLVADYESDSDDEPPKEVPIKKSKADDEEALKSPEPKLESTKITDRIATPIDTKITPSTSKDDRKSVTKKKNIYEDDKKPSTTRSTPSRHNNFQYSNANNNFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKP3</accession>
    <name>A0A232FKP3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000068">
        <property type="protein sequence ID" value="OXU31326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKP3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="184" mass="21048" checksum="59708BEE18559C13" modified="2017-10-25" version="1">MPKREREKSAEQHTWPVCDEYLLEAPRERDPVCKGLAQALIKSSRRLKLRGNPSEIPEEENLMIDRYLKSLGLDNLGSFQSTFHQHIDIPAIVQYTHVDQRLSINGILGIQFQITTTLGLNVHDEHRVTGVVRYQGVEVTLRVAQRSEEVYLDISNTCAIIVRCLKESYVIGHAEIREWTLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKW3</accession>
    <name>A0A232FKW3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000100">
        <property type="protein sequence ID" value="OXU30987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKW3"/>
    <dbReference type="OrthoDB" id="7699665at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9591" checksum="607F661BD6B69A39" modified="2017-10-25" version="1">MDFILHLQKLRLKCTGTTRDNRVKEKNILEKNICATNLWAVLTCMMHTAIMYFQASITNAHVIFNATRDGKKKVGIKELIISIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL61</accession>
    <name>A0A232FL61_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_017010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000055">
        <property type="protein sequence ID" value="OXU31486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL61"/>
    <dbReference type="STRING" id="543379.A0A232FL61"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="458"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU31486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61641" checksum="94E53B4E4C584A0D" modified="2017-10-25" version="1">MVAQEFVDEWFAKQQTRMFSIKDNMIIGNELTRGPVTDSMAKIVLDAFDKDPDFVFQIDAKTGEKLTFAEMKDKSVRCALWLKKQGIGKDDVVVIATPIQNDDYVPFLATIFVNAIYNPWYHELTPAIAKYFFELLNPKIMFVCESAIDMLSGVAREVGSSCQFVVYGRHARFPSLSDLLAQQSQAEIEAFQHVEPVDAKKQVGVIYFSSGTTGVQKGTMLSCDTMVNSRIEYALIRKGANVLWYSNQSWITGSNFILTCIRLNCTRILHANFDPEETSKVVEKCKVNWMFVTPSMLAEMVNAKVFSRYDYSSVEVLMTGGSKASKTILEEIHKALPKTIVSNGFGMTELGGLATRQTRDCKKVESIGHLIEGITMKVLDLRTGKKLGPNQSGELCFKLAHSMLGYWKNPTATKEMIDDEGWVHTGDQGHYDEDGEIFITDRIKQVIIMQNHHISPSQIEEILMQHPEVVDAMVVPVPHPIDVERPFAFVKRVPGAKVTAKELKDLPASYNEYFRLTGGVVFVDEFLFTATGKKNMKAMKEMAKTYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL89</accession>
    <name>A0A232FL89_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000066">
        <property type="protein sequence ID" value="OXU31353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FL89"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="861"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="874"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="928"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1563"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1879" mass="210057" checksum="A2797C4C6BB6A96E" modified="2017-10-25" version="1">MYEINQWLFGIQQSNKALKDVMAEIKLKAKQNEVDLSQEGLFELQCVIKANDIHHAACGEFDDRQFLAFVSGASDLGLYYLRDSSSLPVIKKIPWFQSSRKKIACLCFDPLGSWLLIATIDGSLYIVPAKTLVDEFYSTEQKWTTKDVTSYSSLNAQNSYSRPSAIVWWQGVSFSGQMGIVGTEQGEIIFVNLETGQQVGSTKIDGKITGLCICQDTKLDTVMLLITNHCKEQWHLVLEKPGSNYTYPLNNGGSQRSTMPTEEADNDDSKSFPTTRSRLRGLKQLSVEKLVILKQKLAETRNRNFDSFGARQDNSNRDSNSEAGSNDNENSNESGFFPNHQSDSIKCSTTPIALSNDAYIIPQCLKNDRTIYTRYLSSLNHLTVHERSSSAIPSHVHKMPEHCENIRLTSRFLFISDTRHRFVYVVSRSFSEIRKDDESDLTKDSVIARFSFDKSEEVINSIYTLSSPRMNGNSTLWKNENRIYTIVKDISDIKVEVPPVDTCIVVTNLGVYKIILREQILSIFMDMILKRRSVDGARELGSMFKLNVPELIVNAGDMSLYKRQCGRAMELYSLVGIPLSTSILKFATMGYTSELLSLLASYSADSAFNELSEPNRIHFANLSVLAFTELSLRATPVQNKVVYKDFLNFLSTNTSYDELYAINIAIQNNMWSILHHLIVHRGLGPQVLDVLMKALPTLMSKNSNLVQHYNTHGLLLCLSDSSLIQGMMNNPSTARNHICFVLANLSSLEIFILQRLIALYDPTNPAIRPLVLRFKARRRAASRSSFSSQCDSLDLSEDLDEYGVLIEEIIEIFLQTLLTVLHKKQPSVKFISKYVPFTQLNNIEGGQRERNVSVDFKRRLLSTGFAHAALIRNGNVYTWGKSLQGCLGTGPTISPYSLPQGITIFRRLGIDVLSISCGRCHTLAVTNNGVYAWGGNKYGQLGLGEVRECPNPELITALAQEIIVEAVAGQHHSVAITADGRLFTWGWGVHGQLGHGNAESKRQPCLVTALLGVVVRHVSAGYAHTVVLSADGLVYAFGCNHFGQLGVGNDPKYTSPMRVIFLTERITLISTKYFHNLATSCTNRLYIWGTDPQLLRLHSRERKVRMHKAKVAEAQERELAAASLADKSEEQENANDAGESSEAGAAAVVSNDTPQAAAKSSIVVVPEAEKDEESQHYLVSVCVDTSLVKGKIVQISTGYSHSALLTKDGTIYTWGRNMDGQLGTVHEHDVEIPTPLSYKPPDMFKEKLNMSRKSARKKKAQATDDKNNANNGSETNADINAAEFDATEKDPSYLIKAVKICCGSNFTVAIRPGGNVLTWGNNNFGQLGRAPCDIMDTEEKLIVRFKTSKRIIRCINPSDRFMVIDMTASQVSNIPAPIISYQSYDVSPLAGSIQPLSYIEHSLSDLTLHYAFEQFHGLFSTFKILNKCIELKNYQACAKLELLEHNFVESLAYQFKALKECDPANMETFSNGLPTESLAEDAKSNDILQENNKLFEKHMERNLVDTLMESVKRQKMKMPVSKSLDSFQVIEQELHTFDCQGGSEEMFEDSKYEGMSIEMALEDDNKEDRSSPLSSAENSISREDADNENSLCTNYNKMSLNNSTEARSQCANGNALSRQELLVMRHAVNIVDFYLYEVEEDAFVPTYEIAATAINFWVENKFPIEELEKVFDKYIKKVFYALGLLLFGRCDSQSSPTIEKNEKNIRVKNASKILSTSFCLKVCNLILEQIDEGKPTVEYIEMLSTTMAKNYGPPLTGYPGTSDNKTPEQMMDGIISTLSAKYYDPRPFIHIKDPDKVSELLSAEEDSMIFTCGHQFLISTYQSEAVPRMEAELLALQPPLPSTVQLLGSILYKSYKPETLCPLCLSQVLKDAGKDVADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM08</accession>
    <name>A0A232FM08_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM08"/>
    <dbReference type="STRING" id="543379.A0A232FM08"/>
    <dbReference type="OrthoDB" id="5920040at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="229" mass="25647" checksum="D47FF3C086DD7C8E" modified="2017-10-25" version="1">MEDIPRSIRRAPEDEGCEGLFPSHGRDADGRYVPRLPVKPGAATPLGDSFRGALAALRSLHRRMRYDPVLALEYKGFIEDYLKLDYMRIVKPSDLRTARSICDYIVHHPIWQRGDQGQKLRVSVSKVMIPRLIQTGAAQDVQLHAFSDASRRAMAAVVYVRVSSPSSQPVVSILAAKTKLTSIRSLKPKSTPTPRMTIPRLELRVALIGARLLQTMSAELDIPLDFFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMP0</accession>
    <name>A0A232FMP0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMP0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="146" mass="16244" checksum="FFC873EE6E1FD5F4" modified="2017-10-25" version="1">MAPWGVNNRDLDLDLPPGSGFYKENQPRVSQRKPIYLPLEKKEPKNVEELKEDVPVKKPSKRRLPVREDAILEESFYNTSACKQVTTFNSASAPGDLPCGLIREIFPVLKKLSTKIPITNSPLTGCKSTVIRRPAGLATSDPTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN28</accession>
    <name>A0A232FN28_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN28"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8186" checksum="6EAA420911F3B659" modified="2017-10-25" version="1">MSSAYPKTVASSGSSSLSTPSDMTFHNDGVMSHMHLIAPLHNRAPKIEVNALTSVSALLVHVKDDCKVYALILCGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNF2</accession>
    <name>A0A232FNF2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000008">
        <property type="protein sequence ID" value="OXU32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNF2"/>
    <dbReference type="OrthoDB" id="7634932at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="204" mass="23566" checksum="094A7F7A720275FC" modified="2017-10-25" version="1">MSRAGTDSKSTIVQVKRIQLLGQEESFLFPVDKQTNAQHKQLYENSIVKNVVKSLKVRNKFRNVVLTLSDELKNIYLDTEESVCRNKDRKIKQLKNENINVTNNNEIQEVVASHEEPKNYGEYLQPRSTALPTELSKAICFLFTLCFVSDILAHNRNTFTVYPYSGVSDKYAFSYRFTFLIKQQPSIAQLVERWTVVVTFTVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNI1</accession>
    <name>A0A232FNI1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNI1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="321" mass="35511" checksum="F0849DFEE3ED7FDB" modified="2017-10-25" version="1">MSSELTTKLPYTGQISELNSVNGSNRVKTSVASARSMQGPSSPETQTPNPAMQGDNLAVLKDKMRKTIEYAESRTNVHGPIKKGSQESLASIVSARSIDSNLSTKQIAEYKVSQQTAIKAQEDSYQDAVDNYQVWHEIRGARGRLLKDTVLASAGSKRPRQSPTNSPKKKSVKKHARKRERHERAAMQRETFTPRVPHNASKQLTKARSNKNKRPEGILVKVGQNGMYAEVMGTIRRDVNPNTFGTRVLGVKQTKSGDVSLKLGRGSDSVYCESRKSSAGFWTGQKGRTKGHSRNKGHGPGSYERRVESSYKRSPGKARQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED81</accession>
    <name>A0A232ED81_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_010581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01007754">
        <property type="protein sequence ID" value="OXU16298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED81"/>
    <dbReference type="STRING" id="543379.A0A232ED81"/>
    <dbReference type="OrthoDB" id="7554877at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="11">
        <location>
            <begin position="181"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="737"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU16298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="765" mass="85234" checksum="37F3243BD21B590E" modified="2017-10-25" version="1">MATNCSVSAFWREQPELWFIQTEALFEKHKVTDDTMKFNTVVGALDVRTIDDLQDVIRNPPANNTKYATLKETIIKRTTESPDNNLLKLLTNLELGDSKPSQLWRKMQSLADGKILEPALKVMWLAHLPAPAQTYLSVFKVENVEDLLEAADKIITGSTQVTAVTASDDTSNASSGYGTSILFLVDTGSVATLIPKADAEGDLQKHPLTLHAANQTQISTYGTRRLELSLGLRRNFTCNAIIADVPHAILGADFLIQHGLVVDVKGRRIVDAKTLLASRGALKPAAVSAISSIEAPQQNKGALAGRYDALLKEFADVFDNAISPTCTPGFPVKHVINTTGPPVAERYRRLMGERLQAAHNIFMDLLNKGVIRPGSGKWASPLHLVPKGATFTAPGNVFSTIDLRHAFYQIPIDEDSIEKTTVTTPFGLYEFLGTSLGLRNATQTMQRAMDHILRKLPFAKAYVDDIFIASNNHEEHLQHLQQLLQALREAKLKANTKKCIIGQPQSIFWGYRVTKDGFQPPPAKVEAIRAYPRPTTATELRRFLGICNYYRRCLPHAAAHQAPLHEMLKRLKTKKTKLKWSEEAERAFQQCKASIADAACTTFFEPDAELALRTDASDTAIGAAIEQRHAQGDWRPLGFFSQKLTPTQQRYSTYDRELLAVYEAIKHFERMLEGRTYTFYTVYTDHRPLIYAAQQRADKASPRQARQLEYILRFNVKLAHTPGKANQVADALSRATQEDAAPATQTAAETTNVRDKTTSRFKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE98</accession>
    <name>A0A232EE98_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005539">
        <property type="protein sequence ID" value="OXU16642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE98"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="149" mass="17685" checksum="5737D703CE8FC378" modified="2017-10-25" version="1" fragment="single">MTKKFSTRLMKHGYLLYSLINYDHISHAIAMGLIENDKEIFNAFDEACLTMFPYQLRSYFAWYLIINKLSLAKIIWEKYKIKFCEDFIKKFDNKNLSDRNKMSASENLALCEIEKILNFENYKCSEFGLPQPNTTVIENLTNEDCQNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEK4</accession>
    <name>A0A232EEK4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005295">
        <property type="protein sequence ID" value="OXU16777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEK4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="177" mass="20429" checksum="3B847621F2722E04" modified="2017-10-25" version="1">MLWLGGRGAAEATVTGEGCPTIRSEVEDNVSGWGATERLKRCTCVEETRREKMRTKNKENTLKVPESSTSGIPTSEPGKQDVHLTALKDTIRKTIEALSKRRISLTKNEQNGKFGERCHRTSLTRRIAKYRKSRQEAIEVRKEEEEYITKLEKLDLEDGLFFEKRYDHTSIAHFYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEP2</accession>
    <name>A0A232EEP2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005280">
        <property type="protein sequence ID" value="OXU16798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEP2"/>
    <dbReference type="OrthoDB" id="90756at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="492" mass="54520" checksum="40872921B0D828F0" modified="2017-10-25" version="1">MEHNWISTDDEPEAIYLKCKKVASCYATAKLETANPDVINPANPHSAAYAPDPHAMDVARFQDALKHEIQTGRMSPRDAYDTIALLYPDGGTRTPYPQILPSIKNWRRQVISTNPENLQAFAHQLAAPASLATAVSQWRFDINTFRRQQWRQSHTSAILGKISSLGLADFVRNHKEANFFVRKLLTTLAFHPEDHIGRLFEMLIESSPLTTRRRLQPFCLYFSDFRLQTIGAAGFSIFGIANRTNNIIESYHIRLLHRMGDHPLGWNFHNKNLVLAWRLLYLQHVSLQRFLTICANIIGPQTLLNKMDSLTLSRLTAILQLEQVFQGAVAPRNNMSCIGADLEFNFGIIAAYRVNERLILNDNVLRNPVQDVIDGVQDQLCTIEGVSSQMEEDLGPLPAPGVVNDVPAPVPGVANDVPTPVPSVANDVPTPVPGVEVNVIQPVPAMADDAPEPIPCEAVNVPGVPMDVAHLVLGVAVHLPEPSEPVARQTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEQ6</accession>
    <name>A0A232EEQ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005260">
        <property type="protein sequence ID" value="OXU16814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEQ6"/>
    <dbReference type="STRING" id="543379.A0A232EEQ6"/>
    <dbReference type="OrthoDB" id="2438421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053031">
        <property type="entry name" value="Cuticle_assoc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396:SF25">
        <property type="entry name" value="BOUNDARY ELEMENT ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34396">
        <property type="entry name" value="OS03G0264950 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU16814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="233" mass="26197" checksum="08C8411234801352" modified="2017-10-25" version="1">MHLTETVHELFIHLDHQESLLTCLKDRLHTILVKRKDAQDIGSESLKKIQIRLLNNLSLIESLLKDIFDWIIELYDSLADTVSITSSDMGKSKSEVWKYFVKNSEKNEATCSLCGKVVRSAGNTTNLRSHLQTNHPKIKLEIQKNAKSTAAASTKASSSSLLEMHESSKSPEPPSKKIKTNGGIKAIEANKRLVFLIAKDKMSYSIGEKEGFRKFVNFVAPLYKIPNRNAITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFJ5</accession>
    <name>A0A232EFJ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005011">
        <property type="protein sequence ID" value="OXU17113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFJ5"/>
    <dbReference type="OrthoDB" id="6430887at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47018:SF3">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="732" mass="84235" checksum="FF1704F612A7E252" modified="2017-10-25" version="1">MNKVGVFCLKKHQSLILFTEETFKNCKAILQIGVKYKLAHENVSFTSRPRQIECYHIACYRKFTALSKKYRQELRQTASCTVVPQEETEQPAGPSCSETRDSATTNETERTAEIVEAICSQARRTFDAITPDLRPYPKKPKLIEILPKLPVEATSTIPSSTKTHGTIPLTWVLSHALHIQNTPMWVGFNSLVFTDNSHFNRCKRIHLMINLALTILHFESFAQSENIEVSEEVKNYLVTFLKNRSMVPTIDNIDLLRIIESYEQYSIKTLNGEHGKTAQYYMIYINLINNYLMLTASIRTNDFELFKFMLPRITNLFFVFNQPNYARWLVLYHNKLCRVNETHPGLIVQLEKGSFGVKRTDNKFSKIPVDLTLEQTINADAASRLTGVLHFTNSVQARQRWCKSHSMRSTIITHVLQQTGIRLNQDITAELEKNRTKKSAAQLQSLIHAIKQNINPFDRSFDPNFLFNICSESIRFEARIVTNKVATFADSLKKTIEQSIDFEKVLPYPLTPITFAWCHLDGTHCKTDKSALMKSLEISIDSEVPAYTDVVLIDGFFFLHLMKDVPLTFENISIKLLQSIVKFNAKNIAIIFDRYFSPSIKDCEHAFRDTSENRDSNISGHDKKCSTDFSKELRNIKFKEAFVKFLINHWANDELAPYLGIKTVQLNYDHCYQYTVNDGRINRISHTRRQTKIIFHACNIVKNSNILIRCSNTDILVIMLGNMEKLSSASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFM0</accession>
    <name>A0A232EFM0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004966">
        <property type="protein sequence ID" value="OXU17165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFM0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="420" mass="48940" checksum="2B0BDA3D6BFB6561" modified="2017-10-25" version="1">MSITNQVPLDPMHLLDEGFYGNTGPDALRRMNSINALHVSFKDWVPSDFVRKPLGYVASTSGILDETAEMVNEESAFGGDEYNEPQESLLPQEEHLLVDEENNAELDTELDTEIDDDEDQEMTEDMLQDKLEQQDQHEHTPNENHANQHANHDEPVQEIDPQHRRRRLPINNNNQVLHLEGLLHQEDKLSLVLCLEVLFKTKESLHQVKRIKIVNFGLRRDVIPAPCRTILLYLLRGIEDIRMKLTDRPNNVNKNIINKLQILPINDRNRLLEFDQHLVDPAHRQLRTQFEEKINSFDGDDYKKVVKDILGSTKSRICNYNFPTIISNIIEKKYNVAVTSIKTQIQKWLQKTCDRRRANEQQARRQADIELCNYNVAVTSIKTQIQKWLQKTGDRRRANEQQARRQADIEGQERDLLNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFY2</accession>
    <name>A0A232EFY2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004893">
        <property type="protein sequence ID" value="OXU17279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFY2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="42" mass="4932" checksum="0DAEB1BCED34891C" modified="2017-10-25" version="1">MLIRLPRSKFHNCVNRYRDFKNPGADPRSAFLRSDLFTGGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGB4</accession>
    <name>A0A232EGB4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004805">
        <property type="protein sequence ID" value="OXU17387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGB4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="174" mass="19368" checksum="6BA236BC2301CE74" modified="2017-10-25" version="1">MFLLNLTKYVEYSTDYIIEAVQIPLESKGKKKKLLFLGDFTGLAGTTNRYIGSCRGCFSLSSPISTSVSEIIGELAATKENLFGVPVRLLDLFLSSLFPAALLFLELLDRGNGAIVKTSSSTFHSTFFSDALIKRLERGQVALEKSKKSFGLMISKAKMLRKQQHIQKEDKTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHB5</accession>
    <name>A0A232EHB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004530">
        <property type="protein sequence ID" value="OXU17759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHB5"/>
    <dbReference type="STRING" id="543379.A0A232EHB5"/>
    <dbReference type="OrthoDB" id="7554095at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="188" mass="20615" checksum="69D42BA6F3EED77D" modified="2017-10-25" version="1">MGHMRIATDEVRQALANQKSDFALIQEPYTYRRRVAGLGGSVGVVKGEKPEEKVGAAALHVPGDLTTTKITSLCTSHCICIQVCGAFVEVFLVRLYCQFKDDIEKYLEQRRGVLKHLPGKRILIAANANAKSEWWGSPSSDNRGNILEDSILSNDLVVVNKPGGLQTCRTARGESNIDVTPITPSDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHG6</accession>
    <name>A0A232EHG6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_013319</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004504">
        <property type="protein sequence ID" value="OXU17806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHG6"/>
    <dbReference type="STRING" id="543379.A0A232EHG6"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000021">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="14">
        <location>
            <begin position="496"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11 12">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11 12">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11 12">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU17806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="686" mass="76391" checksum="1B19D8284F69BD4C" modified="2017-10-25" version="1" fragment="single">RLSQSYRKLALYYCYVFVLNCRECNTVDQQDREKQRLHGRYAEPDEWVVRLEGGPEVASLLALRSGYAHVGPVLGFKDTYLWRAKNGFRYKKRGMPYAASNLGSRAKILWADQQRSVRRTKRGYLDDLDPFSIEDFTTAAQPDRRKLSQRAFNDELWDQEWYLLDQRKTEAEAAQPRTIDLNVLPVYKLGVTGRGVRIAVLDDGLEYTHEDLRANYDPEISYDVTDRDEDPMPRYEEPEANGHGTRCAGEIAMEADNRKCGVGVAFEASIGGIKMLDGIVNDRIEAEALGYRVDLVDIYTASWGPPDDGKSLDTPGRLASEALERGIREGRDGRGSIYVWASGNGGSKNDDCGCDGYVGSIYTIAIGSASQTGNFPWYGEMCPANLATTYSGGAFQDQMIVSPATTDLKNSCTTSHTGTSASAPLAAGILALALQVNKNLTWRDVQHLVVYTSKHDPLKNNPGWFRNAAGLWFNPRFGFGLMDAHNLVLASSNWTSVSEKSICQVPAAVWAVREVSYGLPLRVQFEADGCAGAANEIHYLEHVQVETNVEYTLRGALQMHLTAPSGTRVQLLGTRQQDDSTDGFVKWKFMSVATWGEDPQGTWSLDVTDEAGPMNNTGTIRDSKLILHGTQDPPFYLSETLHDCNKVLDEGDKLNYVIEDESNLLDKSEFPKNHSVFDEIVRFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHW0</accession>
    <name>A0A232EHW0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004432">
        <property type="protein sequence ID" value="OXU17908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHW0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="336" mass="38521" checksum="9FE8C3A995CC67F4" modified="2017-10-25" version="1" fragment="single">SFRPVSQHVVLKLRSTFFFDSTTQITPDSLYETVLIFNRTLTEDGWRDVNVEEVYNVDIEDTRYGPTDRNWISEISKIILDNELNNIYGKIGNLKKFLVHKDFLGKITTTVNKSRGEILLLILKFSISNELSFSGLVNLFKLINSMFETPILPDSRHIIDKLVNPKEGVEHHAVCQKCIVYLGKIGDIPSSSICNKITFSFESANQHLLNATKCAKGVSQQVVRFINICHSCSVVKEKVIHQADDDITSPNYILYFNRSDVDDQIITSLHLSSYSSEFFYKMTKNCFTRAYKVCQVIERIHEENRVVSTSSIEKILVDMNVDKIIYLCPIPNLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI08</accession>
    <name>A0A232EI08_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004375">
        <property type="protein sequence ID" value="OXU17983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI08"/>
    <dbReference type="OrthoDB" id="7691180at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="195"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="365" mass="42242" checksum="EEE5B9C17607B213" modified="2017-10-25" version="1" fragment="single">SEFLIPVLCCCCGIVPRQLIDVNTRFSSHDSYVIKAKSYTRAKEDSDFNTKLAQAFRNFGQQQNVTLKSRETKFVTLTSKQGVEEYQLQVTPSDFATAQKDLLFATELLERHKAAVAKQSSNAVLTNFTKDASAICSGSQSTPNTLLLNIDNKTDMSFNHTELIPLQLFEEDTGLTYTLQLYPSLHNRAVNVGAYKWDEQDSKLLVPLYKESQEKYDNGSLTKKKFYTNIMKKLKEAGYIFTMQQCITKMDSFKRSYRKVKDHNAQSGNDPKFYEFYDLLDEMFHKKPWITPLSKAGSNVPMDMDEADDDCKLKSKRRKLSNETEQYYKQCLEEKRLRRKAHARYMEEKLIILRNIANHLPKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI85</accession>
    <name>A0A232EI85_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004312">
        <property type="protein sequence ID" value="OXU18063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI85"/>
    <dbReference type="OrthoDB" id="7699497at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="212"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="626" mass="69271" checksum="FE5506792D7502A9" modified="2017-10-25" version="1">MLDSESMDEDDSLPPGKTADANSSSSAASTSRKPRKRDRVVEVNDLSGDSTDCSNVSLTAECKDEILTACKNVERVAESFAGPSPPSGGNAPALSYAGIATRRALVDSKTLARSISLGRGKAFTLHSLQRIIVDPRAENKDKFSNSRATKETLQSCINPTELKLKDIVKCIVEQNLPGAYLADLNVRDINTEQLLRTAHSNAQLILPHLHDLQTVVRDNDLHVLDINESHLKPSSPALVDIEDFNLCRVDRLGNKGCGGVAIYVIKSIPAKEICRSAKLLVYSKHPEFLFLKLTLKHCKIFCGTVYSPPKAGFWSDVEEAILNCNTAYGAYILMGDFNVDWHSDSSSRTSLADSLGSCLLEPIPFAPTHHTDHSQTTIDYICVSDTSKVVSSRQLHLPRISKHDILFATRSFAIPRYVPSTVRRRSYRGLDADKLLGDLAHLDRSPFYGTADVNAKSPWLTADIKELISPQNKAWRDLKWYRNAVSRRLYNRLRNSVKTAICNAKFGYYRAKLRNCADARVMWNVIGEHEITWSAGTPQMPVDPDTFNAHFIGSAGPVPLQPPSVLKRPPLDSQFFFKYVEVGDVLQAFSDAHSNAKGVDDISLRDLTVCFPVTMHALLDIFDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIM8</accession>
    <name>A0A232EIM8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004193">
        <property type="protein sequence ID" value="OXU18220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71414" checksum="A5A7540F3A92A9E3" modified="2017-10-25" version="1">MLAYVKFLEGPQKNKMHRVPVSKINYKFKDYNNYNKMKKYSIQCTDDKYYKAIVIFFDETIEAINARVSKRAVIPPTKDLDTASEHDSQKVDSLVKKSKSTLEQKQQQQTDDLKLKKYASVLSVKTENLKKIINEKDALKNEAGELSKSSAIMMQVPKSSRPETSTEAKSDKENLTHNKQPLEDTSDSTSQAADGFEPSSLINNDKSVLKPNPGLKIVSEVNGLSTKQSSQLIIKLQDEARKLQKXXXXXXXXXXXXXXXXXKKCTSLEKENEKLQKKYKKVRIEIEDVNKKCTKLSDLNIKLQENILETFKENKDIADKQRGTSVVAPKDGFLNVGYVRESTNMVHLGRDQWLSSVTIASKNLQATSASQFVGHMLTAVFGVSELMKNTVTGKPSNRKVNKNDLKNNDEGVGKLDPVKLEAVKAIGYKLSGLWNRIVRNTLQKKANLMSIVQKKIAYLKRPPRPASKKGLKKGKRTDTNKEEGNAADSKNKDDEGQNSDKNADKSKAEDSIIVEKSTAENIQLDTGSEEIIDEVVIEKPTHQDSFSSIPSQFEPYYEDPIPNKTILAKMMEDVEGEVTDEEDEMKKIENINLDQINKADYSCSSDDQSLYVDEKELEFIDPLDINNDSSNNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK59</accession>
    <name>A0A232EK59_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003872">
        <property type="protein sequence ID" value="OXU18739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK59"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15701" checksum="3B5F2086CF8FDF8E" modified="2017-10-25" version="1">MDRKKKRFLDDENAPISKHMKYKIKKLDKEESAYNEIDESHITNNDTEELICSIEPLYSSITNTTITPDNSASFGLQSILNHESSESFEDPTLQLATLNKNSDFGNFLSQEFSMEDLFDQSFIVKYVFSTNAITVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKC2</accession>
    <name>A0A232EKC2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003852">
        <property type="protein sequence ID" value="OXU18761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EKC2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="188" mass="21208" checksum="855CB539FE895204" modified="2017-10-25" version="1">MRSTYXYVDLEILPFKTRCDFIALCLLAKVLSTKTPDYLGASLNFVSTDRPGGSRRSPLDHHIFVIFPPNICAILSESGLATSGIVCRPDNINSDVCGANLYNRYLTVPEKLNGQHIQMNRDESNMNQAKKCVSVLVETGVHHSSFNYSKQHSHRDFMKIEENMFKPNIITNDVHSAIDTVFQLEAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL16</accession>
    <name>A0A232EL16_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003680">
        <property type="protein sequence ID" value="OXU19008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL16"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="43" mass="4642" checksum="E3879042D6C390AC" modified="2017-10-25" version="1">MAGNAAARKGTLRSNKSRCVHVKLLTSTKKGTAPFRETALRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELC3</accession>
    <name>A0A232ELC3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003576">
        <property type="protein sequence ID" value="OXU19166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ELC3"/>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF0">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1167"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="607"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="759"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="858"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1361" mass="155329" checksum="4F0AE0D441D37CF1" modified="2017-10-25" version="1" fragment="single">SVPEVIDYARRLGIDPDSEPHLLDLAREGLMAALPKGWTPVYNDAAKSFYYYQRSTNVTTWEHPLDAVYKDLVAQARASNRRRASVALFKFKFLLRYRIYPQIYVSTGATWNKSAWNARKKAFFADEDSKIRADDAEPDYQQLPASSGLPPPVPGPLKSPTTRIPMKLAPLKRHRSESSSGFPRRSPSSLDRLTRGWKSGDSDMEPYSSSARSSLSSDRASRDYTNLRFQDPQFYESPKIMDNDKKKLDFRDVLKRSESLSPRYEEDWRQLSNRFSSDENIIDIENLASSALKQKSRTPVTPSRETASSSVQVQQLQHPKELTLSGGGSIFLKSNRSRDTTPCHDETRSLEDHQAAGGSDLVLPGGGSLDDMSASTGERLKSILREKATEDDERPFEEERKSVRFDLQKVGIETAVTKFNDSDSDEEDTEGSGPEERTGGIASVIAARRAAAVFSLQQVLNRQGGADFGPSRTFVKRVDIDVKNPKIVGNRFVVENVSEKEHMQQQESRSIDDDEFLPNKFENVKNIDLISKSDSEKTTPRSSESRSSFLDDLRKSKEIMMENMKKSELRAKKIAEDEARIAGNQSWSSKMLRSLELSKEGIKSPPSENLMTNLEAIKNNMIKENENEIRIFKQELDSKLVEVKNQLEKEFSKEKQSLEASIQKKLLELRKEMTSKEEHEIKKLIEDMGEVRADNLKKVRNELEVCYEKERQDILSNLKGELDQRKRELLELRSQEISKLENEHERGLDDDKQAKIVEMEITRQHNERIEDLRKELDREFDNVRADLRAQQREKITKITEDHEKCLADILRDFRVDEVLARKVYKQRLDEIRADYSKDVENEMKKHNDSAVRQESVDFEKIRCEKRLLEDKYNTLKEKYLKLKKDMRAAIEKRNRRKEQANTTASETEMSTSTRTRTERTESTDQKSLLTKTNSISNSKPKEISRQNSNALKDQQSDFQQQQPQQRLVVTSVAPPATNQPAATATALQKTQKFESDDTTTCSETTSNLLMMSRKKKCFTKKPSTGANKINNNMTDNPVENIRKQLEKLEDLGDQLPSNETAYTVRYPFQDKSPTNVSSELEFFRHRIHVERDSVKRAREALRQQRSAFQSRQRAWKQRSARATLEQLVKEERELSDMEVSLHRTRSLLGEKVIHLRHLEQSLERVANAKRSDYKSPTPSAATTTGNKSDEVTLSDMSSASSGFSSTDLGTDTFIDKYCHYQESTEIIASLENLNSEIREIWGVLNKRQDNTIPPPPTLMYTDLSWFPYQHLTTQPTTVSAAFGTPNIQSNILSQLTAGHPPSATQNIIAQYGPTSGYTTSVGTVEGSVAPNLIERTRNLKDWLRQARVETSDLVSPGQATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELT9</accession>
    <name>A0A232ELT9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003517">
        <property type="protein sequence ID" value="OXU19288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELT9"/>
    <dbReference type="STRING" id="543379.A0A232ELT9"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052644">
        <property type="entry name" value="ZMAT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="425" mass="47006" checksum="28F598D84E42D0A4" modified="2017-10-25" version="1">MSKSTLLDKIKNPDVPGFEEVLPPPPPPPPPPIISENAPEVVDNNSSNPPFPNVPPASYYMTAQAHIQATANQPWWLPTEVDTSEVYTQWYESAYKAALQSAQEKDSIGKNKVKYYKRKAEVIDPKVDAEKVANAQKELSVLMKPLKCDLCNAVMNSTLQARLHYQGKPHQKKVSMFLNQSAKKAKTEDGQVSSTTSSDWNTYCEICKIWFTSQTDASQHYAGKKHLKAAFGTKVKSPKKTQPKVQIDPTGRYGIGMAFQPEIAVAQPPLPPENPPIMVPVIPAVAPLPPVPQYSQPAVPFPAPLRCDLCGISANRQDQLDTHKRGTKHMKMLKLHGLPLTGTEMLLHCVNVNVLMLLETTPAVKTIDYSIYRTPSGQYYCAPCNISLNSEISFGQHMESKKHKNQVNPKQPAPSSPVAKKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM89</accession>
    <name>A0A232EM89_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox protein unc-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_005617</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003421">
        <property type="protein sequence ID" value="OXU19438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM89"/>
    <dbReference type="STRING" id="543379.A0A232EM89"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000057">
        <property type="entry name" value="Short stature homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="246"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="12">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="248"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU19438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="449" mass="48832" checksum="22CB73D17194BD3D" modified="2017-10-25" version="1">MPDCAVRGCAQSMEQLAQFVSKSFEGPGQLAFALHHHHHHRQRHHHHHHKREEEDQEQPRRLQAAISLSVAQLVGAVVAGCAKTADDKDQEEPNERNGERILDPVRENGKSEMGESEHQQDSSSSSGNSVVVSSVKEPSSPETTRLQPEDLSLSSTQKLKEETEKRLTKPPELKLSVRKLLGCTPSPPPVISRDRSCSPCDEQKEAEVRPAPILSRPSLLQLDDAKGSASSSSGNGRSGAGSGGNGKQRRSRTNFTLEQLAELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKHESQLHKGVTGGMVLAPRSPPTSLEPCRVAPYLPALRLHPQIQSANSAASAFDPAVLHYAAAGGLFCLPGGHPNTSSSAGPSGSAGNPHHLNLAASLAAAAAANSRSKSSSIADLRLKARRHQEALGLERPAYARDYRYSVNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMJ1</accession>
    <name>A0A232EMJ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003348">
        <property type="protein sequence ID" value="OXU19574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMJ1"/>
    <dbReference type="STRING" id="543379.A0A232EMJ1"/>
    <dbReference type="OrthoDB" id="6614499at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113340" checksum="E0A5D8984CDB4066" modified="2017-10-25" version="1">MTHISTIREISVIDISVDTSTKSANKSVRSTRRTRKNQNAKGSDEENDNPREVNNLTDNITVTSFSNDSTLSTRKQRRKVQESVLSQDISLSVTLDESKQKKSNLKTPNAKTQSKSSKSTKKEGDSLLSEDESFNTKSQKGKKRVFYAMDDLISEDESVSQASSSKQAKSSNRRSKTPNKPSPSKKPIIAKSTGGNVTPKSSPINVSFTPHRSTKTPKKSPINLGSPKTLPRSSLKLLNVQRKLSITDSPPSSENSYNLVEPQDSASPDNKPAENTSMSDKKSKSTKIKSNSPTLKVRPRFSKSPKIDLKTLKAKSNKSPKKSPKVSPTKSEKSPAKSVKSPAKLSTSPKKIEKSPTIAVKSTTDTSLKVDETSKDLSPVKIKLPKSESPQKSDKTPKGDSSFKSQKSSSEKLFRSLLKVPSSTESRKSFINTSLKSKTSSLSTSFKSKKSPLLNLSSKKMPKIVLNLKSNKSPLKSSKSISPSKAKKSPVKTPKLKSSMKTKKSPKSVSPTKKPSTNLILNKSISQDTSLSPRVVISKLTHSSTPGIKSSVLNITGKQPSINLIPIDHNNQPSTLPVKSPKSPKSLAKRSTIKSATPAKTIRTSMSAAKKVNAINTPSHDIEKKLLNMRPANTSTPRDRNMKRTLTLGSNKKITSPKQVSKSIILNGSPNSKSKVIKRLNNTSIQADNPLLEDESEPSLNCSSLIHMSDIFDSDNSKNNSTFSIDKSGLGTSRKRKSINSLNISQKGNKSNTFEVKKNASNESIKEISKKDNTYELEHPKTPALQMRAKKRTLDEAELGITEEQESKKICRVTFASPNLGNKVRSTGITRMGTPGHAIQQKKSPVSVNKNKTPVRKVEAKRRLSSVMKSHSKTVASTVEKRLSQIASVNRLSRPRGITDSEKKVAKTPVATKIPNFKEIHQKNFAKMESLVDLKKRVEQRHEVLNAATSSIKKKKPVESVKPLPPDSTNGAYSRFGFKLRKNEAVDIISKKQTGGVESREKKRENARSALKGVRMNRRFELQMKSRMKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMJ6</accession>
    <name>A0A232EMJ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003346">
        <property type="protein sequence ID" value="OXU19576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EMJ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="638" mass="73163" checksum="532DB47EA8E60611" modified="2017-10-25" version="1">MGEYYELASEVAIEIIKPMRESDRLQTIRYDYAVITWLNGEAAKNELATHXCFRQLSNTSLRKHVKKCTKLSFKSNRSIKENSRAVMGHYHELASEVAIEIIKCMRESDRLQTIRYDYAVITWLNGEAAKNELATHHFKKTRADLSRLGTLKLHMMQLSNDISEFSDLFNEDEYENFIEAFITWLNGEASKYELATHHFKKTRAYLSSLGTLKLHMMQLSNNISEFSDIFNEDEYENFIEACKMMGKFTVENSKKVMRAPATASDMFYLIQRVATMYSVELGLSKKAERERVQAFLTKLKAKWHCSLGNTIAESQAAFKRQKMVKLPDKEDTHPPSYLKCLIDNRNRAKLSEQNPYIFVKTNDVDRNFTYSLATSRMNEFAEKCGAKDPSTLRGTLYRKQVVTEGMVQGLDPHNVEALSSYMGHTTRIHHQNYCQGVFDRDVKISKLVRESQSLNKAPATHLQENNDANIDYSIEIEEQSQCEDEGCGSENDLNTENHNSRNDDKSPNKIDNRNRAKISEKNPYIFANTNDVDRNFTYSLATSRINEFAEKCGAKDPSTLRGMLYRKQVATEGMVQVRESQSLNKAPASHLQENNDANIDHSIEMEEQSQCEDEGCGSENDLNTGSLSNLNHYHRILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN23</accession>
    <name>A0A232EN23_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003258">
        <property type="protein sequence ID" value="OXU19722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN23"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6928" checksum="41C7FDDD6553DDCF" modified="2017-10-25" version="1">MLTLHYYYNGQSVDPACCFDDIDHEDDAAPVYSEDLIKEFDTKNPPLEDELAWILSKANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN41</accession>
    <name>A0A232EN41_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_004553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003241">
        <property type="protein sequence ID" value="OXU19747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN41"/>
    <dbReference type="STRING" id="543379.A0A232EN41"/>
    <dbReference type="OrthoDB" id="2132119at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09568">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000002">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000004">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037622">
        <property type="entry name" value="LIP-1_SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="414" mass="45815" checksum="372390CE772B0671" modified="2017-10-25" version="1">MQHRHGQPNNGALNSGTPSPLSSRHSSQDSLHKNNLACGLPLGQFAGSHQFHMQATMSPATAAAVAAAQKKKGIKSSLGRFFSKKEKIKGKDMSMPGDMGMGVSTPDPDYGEIAAGSVAGTLCNKGDFDRRKKKSMLDTSRHELLTEAMKAGTPFALWNGPTIVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPKTSRSTLAFGDMNHEWIGNVWLPSLGLPQYRSTFMECLVDARMLDHLTKKDLRGQLRMVDNFHRTSLQYGISCLKRLNYDRQQLEDRRRMAEGANVDVLVWSNDRCIRWIQSIGLKEYANSLLESGVHGALIALDESFDANSFALQLQIPTQNIQARQVLEMEFANLLTVGTERRLDETNSMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENR2</accession>
    <name>A0A232ENR2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003107">
        <property type="protein sequence ID" value="OXU19962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENR2"/>
    <dbReference type="STRING" id="543379.A0A232ENR2"/>
    <dbReference type="OrthoDB" id="7700353at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="200" mass="22242" checksum="57ED34DD603754EF" modified="2017-10-25" version="1">MPNIYSYNYKSISLPLPVNTVLGKTLKSANEPNCVINNYLKSKKALAVYTDGSKSDGTKYTGVACQCHDLNINISIAIDKTASVYTAHCVAIFKALDIALENFSYNYVIFSDSLSLQATNLKTNILEIKRKYNAYTSHNPDRFIQFIWVPSHMGIIGNEKADELAKLGKPLQSLSITRVGIIDNAQYQCGNENQDLNHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP65</accession>
    <name>A0A232EP65_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003002">
        <property type="protein sequence ID" value="OXU20144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP65"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="30" mass="3718" checksum="369A824D3709A132" modified="2017-10-25" version="1">MVTTSTQFRHRAPRYYNWTTRGTRFLTRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP78</accession>
    <name>A0A232EP78_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002994">
        <property type="protein sequence ID" value="OXU20153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP78"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27711" checksum="56A5A260F8BBE0AC" modified="2017-10-25" version="1">MLMNAAIHLGTSYACIRTKRPGLSDNERMMIGFAHNLLRNAFSLRKGHIISRLSYGTTSWRSWLRDGRITTNVDLSVDKFRTVVYQNVGKKSYPGSLPGQKAAEDIPKLMSDIATEWYQQPHNPVSCCFNFWEHVNEIEELKPDTERFETINVVGCGLTKTSRCSSRGHPLPGCVDYFSIHLVCNYASKEDESKIEYDTSSSNLLIPIEIQTVALAQRLDEKIARLVVYWRKKVYKLIATCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQB2</accession>
    <name>A0A232EQB2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002801">
        <property type="protein sequence ID" value="OXU20543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQB2"/>
    <dbReference type="STRING" id="543379.A0A232EQB2"/>
    <dbReference type="OrthoDB" id="7701605at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7402" checksum="F0B605C2CA2E0BA8" modified="2017-10-25" version="1">MPRSRRRHRSRSHSRTHSPASPQYDHKRRRVDYESPPRKGTYSGAKVLVCRRNGRKRCSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERI1</accession>
    <name>A0A232ERI1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002585">
        <property type="protein sequence ID" value="OXU20983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERI1"/>
    <dbReference type="STRING" id="543379.A0A232ERI1"/>
    <dbReference type="OrthoDB" id="7700262at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="683" mass="77874" checksum="3D635D8186CFF104" modified="2017-10-25" version="1">MADKDRHKHQNTPTHSSCIPRTGSYPNLTNRGEAKGNPLRPNKNPNENKGNDRKSLIQARLNHAKNSNSPKDNRSIQTNKSNNSSINEFQNAKSQNNIDQSMDIEEHEMNVQKFTENMNLETISPNEIANIIHTPFSSEVQQNQTNAQIDVGALTQPNNNDANSTSAKESRETLSKLKKRSAAAQSPISPREHHHTKRLANINIKKSLFQDSTLPTNSNDSETAVTRLPSEYDITISGPYKIYLQSTDVENKRLDAIKVAKLLIPKFPMKDSINEIKQLSYNKICIIAKYRNVANTIIGLPDWNDLQIRAFIPNHLLTKQGVIKGIPTDITNEELKQNIELDSPFGPLEIAHIRRFTKKVYNKTTDKAEILPTQTIQITVKGQFLPTEAKVLKVIYPIEKYYPQIRQCYRCFRFGHIKLNCKAPNEKCIRCGETKHENKEECTKIQAPPTCLHCHQNHLPIDINCPRRIEEQNIKNMATDYNITVAEVKNQLKKKVPINESHFPAINKSSQPNLKLAEAQNQISYADKVKTNPTQNGFTLNHQSQQDKEDANNQTTFRFTQPSPQKHSNKKSSIHLNKEWLRSHSECLSYPNGNPNLKFKPLANGKSAIDFFHQTDNDQLQRTRTEPSTVQIENKLDYVEKIISELSNAEIAKIDNLIQKKKEAITQYSLENDEINYEITSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERP9</accession>
    <name>A0A232ERP9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002564">
        <property type="protein sequence ID" value="OXU21039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERP9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="6906" checksum="00341382178082C8" modified="2017-10-25" version="1">MEHGRKVIVVPETMAMRLQNTTQLTTVQQQHTIPAPPTTEGSVQMPGDNLSRLDAKMHEIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES42</accession>
    <name>A0A232ES42_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_012227</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002541">
        <property type="protein sequence ID" value="OXU21106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES42"/>
    <dbReference type="STRING" id="543379.A0A232ES42"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189565" description="Spondin-1" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="15">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="16">
        <location>
            <begin position="176"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="708"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="575"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="822"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU21106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1015" mass="115743" checksum="CEDE7A35022E2A2B" modified="2017-10-25" version="1">MQLRKFSQLAILLLAGVVVNGSTHCEQKWDDIKAPHTVSETYRIKLLKINTTDEFRSFMPNTKYQVMVKNEIEDVQFIRFYITVENENKSLPHGVLELYNEELSEFTQDCPDAVVQVSQVVKDDISVYWTSPEEGNGCVIFRASVMESPSVWFMDGTLEQKFCQDPKASFDDPGPVLPECCACDEAKYELAFEGLWSRYTHPKNFPSKPWNARFSDVIGASHTSEYRFWEYNGYASEGLKQVAENGVTRVLESELKNQSQHIRTIIKARGINFPNITSKTFAVFRVDQMHHLMSLVSMIGTNESLGLGIRMRCNERHADPSPDWFVGVSGLELCLSNCSWIEHKELNLYPIDAGTDDGITYESVDAETEPRDVIRRITTTWPNDDRSPFYDDSAVDMNPLARLYLKRQRIYEKNCERSPSFEDSEGLGAVVDQPITRSKVTNWGPWESCSVTCGRGVKLRQRKYKNEKAAAKHNCDSLLTDRVICYAADNFVWSRIIPCIESERRSSASDCSPPDEVDEKKCPLSQWSEWTICSKSCGPESRTRERNFRPKRKRKECRMQYPRIELQQTIDCDNPACEGEEATTDGDSSTTDVAGDEEAVSETTTESITTTVSSDEESDYDAADNRRYLAKIWPRPRRKKCPESRYYQWSFWSPCSVSCGSGTKSRSRQIKPEYSPNAADYECQYESAICEAETKSCQITPELMQVICSQPVEPGHCPDEHDDNSLRYYYDKITVKCLLFHYTGCNGNMNNFRTLQECQTTCSTFRKSFFTPIAHALSCLINNFFFLFFLYPQPTNTLTDEEDPDSLKNYKLKLSSVVTYNVPLTDHPNSKNKRARSDENTTEKKKKKKHKGETKSNDRVDCRMTEWSDWSPCYSCKGYRTMSRDVLTHPRNGGKSCPTKTMRRQKCHKVLPDCNVQNDREALVFDSGEEQGTINARTTLQNCDLKNNDASALTVSVHCRVSPWGSWSSCATSCGLSQRRRTRKIAVEPRGTFGKSCPALAQIETCRLPACPNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETE1</accession>
    <name>A0A232ETE1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002284">
        <property type="protein sequence ID" value="OXU21625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETE1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059415" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="68" mass="7817" checksum="F82975CA0DDE1742" modified="2017-10-25" version="1">MPDRDINDFRNFKFLLLLLALVLPLALQTNTILSHTRYSIDIVKNLASILVYSGLVNVLQITITRKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETH5</accession>
    <name>A0A232ETH5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="6 20">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_003676</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homooctamer; active form. Homohexamer; low activity form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ALAD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="6 20"/>
    <dbReference type="EMBL" id="NNAY01002271">
        <property type="protein sequence ID" value="OXU21665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETH5"/>
    <dbReference type="STRING" id="543379.A0A232ETH5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000720">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000029">
        <property type="entry name" value="Heat shock 70 kDa protein cognate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="15 20" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="941"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="955"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU21665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="965" mass="105753" checksum="9D712604B5816D98" modified="2017-10-25" version="1">MEIESKNILHSGYFHPVLRQWQAPNVGITAENLMFPIFVLDEPNAVTEIQSMPGVNRYGINKLKGLLEPLIAKGLKSILLFGVANNLPKDEIASAADSPANPIIQALPLLRKWFPSLIIACDVCLCPYSSHGHCGMLNDDGTIDNKPSIKRIADIAVAYAKAGAHIVAPSDMMDGRIKAIKHGLAAAGLSNKVAVLSYSVKFASGFYGPFRDASKSAPKFGDRQCYQLPSGSNGLAARAAARDIEEGADMLMVKPGLAYLDIVKETKNAHPEYPMFIYQVSGEYAMLYHGAQNGAINLEAVLKETKMKGATALLLLGLVAAIAASKEEKKDKDDIGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWTDATVQHDVKFFPFKVIEKNSKPHIKVSTSQGDKIFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGIISGLQVMRIINEPTAAAIAYGLDKKDGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRALSASHQVRIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDADMSKKDVDEIVLVGGSTRIPKVQQLVKEFFGGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQIFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGVPQIEVTFEIDANGILQVSAEDKGTGNREKIVITNDQNRLTPDDIERMIKDAEKFADEDKKLKERVEARNELESYAYSLKNQLQDKEKLGSKVSDSDKAKMEEAIDEKIKWLEENQDTDPEEYKKQKKELSDIVQPIISKLYQGAGGGVPPTGGEESDDDLKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETL8</accession>
    <name>A0A232ETL8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_000507</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 16">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002259">
        <property type="protein sequence ID" value="OXU21710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETL8"/>
    <dbReference type="STRING" id="543379.A0A232ETL8"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000069">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000077">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000084">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000089">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000289">
        <property type="entry name" value="RNA polymerase-associated protein CTR9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14 16" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="18">
        <location>
            <begin position="1166"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="838"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="883"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1149"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="930"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="952"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="966"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU21710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1269" mass="144448" checksum="C68D543EBFA994F7" modified="2017-10-25" version="1">MAGSIEIPLRDSPDEVIELCLDQLPDGDEVLGILRQEHAQLNIWVNLALEYHKQHKIEDFIKILESSRVDANNEYRDYEKDQMRALDMLAAHYVQEANREKNKDKKRDLFTKATLLYTTADKIIMYDQNHLLGRAYFCLLEGDKMEQADAQFNFVLNQSPNNIPSLLGKACIAYNKKDYRGALTFYRKALRTNPRCPADIRVGMGHCFMKLNNHEKARCAYERALQLDGQSVGALVGLAILELNDQDPESIKAGVQMLSKAYTIDSTNPMVLNHLANHFFFKKDYNKVQHLALHAFHNTENESMRAESCYQLARSFHVQGDYDQAFQYYYQATQFASPIFVLPHYGLGQMYMYRGDNENAAQCFEKVLKAQPENYETMKILGSLYANSTSQSKRDIAKNHLRKVTEHYPDDVEAWIELAQILEQSDLQASLNAYGTATRILNEKVQADIPPEILNNVAALQYRLGCLDEARKKLMESLERSKADAEHDPSYYNSIAVTTTYNLARVYEAQCMFDKAEKLYKDVLKEHPNYIDCYLRLGCMARDKGQIYEASDWFKDALRIDNEHPDAWSLLGNLHLAKQEWGPGQKKFERILKNPSTNNDTYSLIALGNIWLQTLHQSGKEKEREKRHQDRALANYKLVLKTDPKNIWATNGVGCVLAHKGYINEARDIFAQVREATAEFPDVWLNIAHIYVEQKQYVSAIQMYENCLRKFYMYHHVEILGYLARAYLKAGKLKDAKLTLLKARRVAPQDPVLLYNVAYILQRLATMILKDEKSTLTTVLQAVHELGLSHKYFQYLGSHGDRMEQVAEAEARRCQDLLSQAQYHVARARRLDEEEKMLRKKQEEERQAFKMRQTEEQRKMEEMRKQKEEQMLQKRQEYVEKTKNALVFGEMPNEKSGKKGKKGKTEEYISDSGGSGNEVDGAEGESSREKKQRKKKSSDHKERKSRGKGKRKRDDDSGGSGDDKPKSKRGKKSGGRKEKSSKKSNKEYSVPKSRIISKETISTDESESDNERSKIKSGDESDSGVPRGKRRIASDSEGSRASRSRSRSRSGSGSRSGSGSRSRSRSGSGSRSRSRSRSGSRSRSRSGSRSRSRSRSGSGSRSRSGSRSKSRSRSRSSCSGAHKTKSTNATRQHSVYVRTPNTILAMAPKASGKAVKKAGKAVKNITKGDKKKHKKRRKESYAIYIYKVLKQVHPDTGVSSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU15</accession>
    <name>A0A232EU15_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002180">
        <property type="protein sequence ID" value="OXU21860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU15"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="227" mass="25869" checksum="22FD62D4C9D53FEA" modified="2017-10-25" version="1">MCVADGQSTFERDEALRLAVAFVTLERRGEKQASSGIVVKIKTRAIFEKTEEKRRSFFELYNPLVRQATVHNVHALCSSTNLSHFSTEKMPLDRNRETQKSALCEIISGDGEGKRLLCAAEHTDRDRAIERLLQLEPGLSEIFPKGDKFSLLWIAVLRCYRQSAELLVRFGADVNELCGTKLAPFLSETISILHLILQTYPSTWNLIVIEKHKSKTFVRNNHIPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU95</accession>
    <name>A0A232EU95_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_010416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002146">
        <property type="protein sequence ID" value="OXU21939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU95"/>
    <dbReference type="STRING" id="543379.A0A232EU95"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="55"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU21939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="215" mass="24098" checksum="9C020E482414F71F" modified="2017-10-25" version="1">MTDIDKYEDIVQTPDAVTAALSTELPEIKLFGRWNCDDVHINDMSLQDYIAVKEKNAKYLPHSAGRYAAKRFRKAQCPIVERLTNSLMMHGRNNGKKLMAVRIVKHAFEIIHLLTGENPLQVLVTAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUX8</accession>
    <name>A0A232EUX8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_007699</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002076">
        <property type="protein sequence ID" value="OXU22151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUX8"/>
    <dbReference type="STRING" id="543379.A0A232EUX8"/>
    <dbReference type="OrthoDB" id="5573735at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF83">
        <property type="entry name" value="INTEGRIN ALPHA-PS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="121"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="261"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU22151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="682" mass="75952" checksum="EBCB761B59B199D3" modified="2017-10-25" version="1">MKQCPTRGANGRTSFSVQRITGELEESGARFGSALSCLGDLDYDGYADLAVSAPYEDEHRGAIYIFQGRAEGIAERYSQRIRAAELSPRLQGFGQAIARDLQGNLAVGAYLSGHAVLLASRPVLVMSLEVRVSENKYSLLTNQTNLPLEFCSSYDGLNNNAPNVIDATFTVQVDKFHHRAIIYEKVAFGDTYRLVATLTKGQEKCTSIKAYFKKNHQNFIDPIMVNAQVNLTDSSCPNCPVISPQLSKTVDELKLAFLLDCGEDAVCVSDLRVVNVTSPDLPTGRFVIGSKPSVNLSLAIENNGEPAYRAQAHVYVPQPIGLARIPPECNEQAQIINKTLELICNAGNPLRDNASILAYSLIYTLLLELDMSAIVYEDETQEIQVVLTSQSKEKHFFDNIQTFLISYDVEADVAIVGKSYEDSYALFERDLTERNYSKHSFDHVYEIQKFGATPIEEAHFTLNVPTHWNDSEIARIRHVQGYMEGRKLDCKNVGKEESDSVLMLPLNRTLFGEGNNSVTVTSEARAFYVNCTNQDVACQTFLCILGPFVRKNSVAKVTVSMDLEPSNNTSIIEEMKGKDVLLFVSEAFVKITQPNITLESDNKKPDFKQISTMFFRLRQAKEAAIVPLWIIVLSVLLGIVLTTILTALLVKFGFFNRRIKDDLDALKSTDEVNRQSEGIEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUY8</accession>
    <name>A0A232EUY8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002074">
        <property type="protein sequence ID" value="OXU22157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUY8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012443858" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="44" mass="4730" checksum="AD3324F58BE699D5" modified="2017-10-25" version="1" fragment="single">TLTSINPLSRLSVALAVLFCTVRLAPERSESDTHGAIKDYSCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV62</accession>
    <name>A0A232EV62_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002054">
        <property type="protein sequence ID" value="OXU22227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV62"/>
    <dbReference type="STRING" id="543379.A0A232EV62"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="302" mass="34905" checksum="FA56B7DA749B38D7" modified="2017-10-25" version="1">MEIDKQIKELNNILSKQSSTTSGKDDLNGLAIFEHFIPYELLSRIFCYLKSNELVVCHLVCKRWNEHIKEYVWRKKAELISGQTFPFDEKINWVSYYLLCAKNAFNRNLLLSDKVVARDDNEYDHGAFETIEFDKNENPPPINVMPFPEDLVVNDQIRCSISSPLSSSGAKKSFRIYLLKEGLTEKILNNIQPIIKVSVWFCCKLDAKEADFSCYTRLIGRPYPEDPDASAFVMRSAQFNKRLNNVDQKGKWFQCTFEFKNYGKGLRRIKFYQEASGEVIVGGASIRLVVPDLDENFDKTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWX1</accession>
    <name>A0A232EWX1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01001812">
        <property type="protein sequence ID" value="OXU22852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWX1"/>
    <dbReference type="SMR" id="A0A232EWX1"/>
    <dbReference type="STRING" id="543379.A0A232EWX1"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16744">
        <property type="entry name" value="RING-HC_RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000062">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU22852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="184" mass="20314" checksum="E3AC3E895533A125" modified="2017-10-25" version="1">MVMTEEQPGPSNPSGSATEEKERDDRMFECNICLDTAKDAVVSMCGHLFCWPCLHQWLETRPTRQVCPVCKAAISKEKVIPLYGRGATKQEDPRNNVPPRPVGQRSEPEANVGFPGIGFGDGSFHMSFGIGAFPFGFFTSTFNIGEGSRPSAAPRGSTQFEDDTFLSKLFLWLAFAFIVWLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWY0</accession>
    <name>A0A232EWY0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001812">
        <property type="protein sequence ID" value="OXU22850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EWY0"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCD" evidence="10">
        <location>
            <begin position="356"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1548"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1584"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1651"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1755"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1783"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1811"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1839"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1865"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1895"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1291"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1429"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="304"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1292"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1318"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1973" mass="224658" checksum="B182660EB8EFB98F" modified="2017-10-25" version="1">MHRRGGKRIRMDDPVPPEYETAMITNESYSETPDYGQSSNDYQDPTLDAQLAAPSNMRITRNTRARLRGGPIQQPKYKEIDEDYIPSASSAAAAAAAAAAAAAAATHHTTHTTHHVTHAPHTPKVRATGRGRAKRAHQSHNLEDETSLYFAVRNNRSSLTGIVDEWIEKYKLNKENALLMLMQFFISASGCKGLITAEMQSLEHTQIIRKMTEEFDEESGEYPLIMSGQQWKKFRSNFCEFVQILVRQCQYSIIYDQFLMDNIISLLTGLSDSQVRAFRHTATLAAMKLMTALVDVALTVSINLDNTQRQYEAERQKNREKRAADRLESLLSKRKELEENMDEIKNMLTYMFKSVFVHRYRDTLPEIRAICMAEIGIWMKKFHQNFLDDSYLKYIGWTLHDKVGEVRLKCLQALQPLYASEELKTKLELFTSKFKDRIVAMTLDKEYDVAVQAVKLVISIFKHHREILTDKDCEHVYELVYSSHRAVAQAAGEFVNERFFTSNEEHDVKTKRGKKRLPNTPFIRDLVLFFIESELHEHGAYLVDSLIETNQMMKDWECMTDLLIEEPGDEEDVLDNQQETSLIEIMVCCIKQSATGEAPVGRGPTRKILSAKESKQVQEDKQRLTEHFIQVLPILLDKYRADPEKLANLLSIPQYFDLDIYTKSRQEQNLDLLLRKIHDIVDRSPNSEVLNTAAKTLEYMCVPGSAIFRKCDVARSTLIDAIVIKYNEAITTFKYQMDGSEQPTEDEIFAVVESLKKVAIFYSCHNMNSCDIWEPMFKDIKDYPYNLPVEAIKYCINACFYSILWSQSDLIENLEGDNRADEEAQRLRGRLHDFMRCMYEFISTENEEEIPILLKEEAYNTICDLLVIFCNQLTTQKNQLLHQLVYEADVLMQDSLNRFVQLYVFSDNEEDEHDEHSKIEELHKKRNFLAGFCKLIVYNMIPTKAAADIFKHHVKFYNDYGDIIKTTIGKARDINKTNCALTMQQSLNILFNEILEKEDKVSRTSEEFTAIKELAKRFALSFGLDAVKNREAITALHRQGILFAVSMQDSDVDPTGPPPNLAYLEILSEFTNKLLKQDKKLVLNFLDKHLQAGMPSSKGEDWQPLLLYRNSLLHGDTDTIPVTSKRAYTRRRKDLIAEEDDGDEGDDASDHDLTCPMCCGETFNNSESLKYHLLSITDNLYCPGCSIRTYSMAALIQHLDCCGKQEEPEEQQKLREVMPDQTENNENAAEGSNILIHDMPDNDEDTINDSFLATVNEEGIMIVGEGRTIQVDENGDIQVLEKGTLINSQKSNDIDNSIKQDNYEDSETSNPRPEETNLEGNSCTSNMPDTSELLNDNSNEFMEMVDGDMPFENHEMLGIKKEHDQSDEKEQEDAESEVMYSCSTCGMSFASVLEHIKEYHDGQEVVLEMAEQQIDEIAATTAAQNIDESPADANASEETTNNATTKANSSKQRQAMNTLKTEECIDSDGRLYTRKVVQIERFWDRTPVTLSTTKAPMIEKFFSNVEGVKVRDKSVTVAPTRMYRCNQCLEQFAKLSDFRIHVCLQGAHRCDKCEQTFATPKALQIHIKQSHLIESSEIPSQNLFLCTVCGTKFQTHKSLRLHSRMHAPVRSRHVDAPVGTGEETFDCNECGATLSESYRLAHMALHAGDPITCHVCNRKFDSKESLNMHAAVHLEIPMNSNSGAANSAAMALAAANEMIISTTEDPTDPIFVSTGITPDKTTQVNTMASTSSTVTTTTATTTTTDSAELQNQKPYQCQHCGRRFTRPHEKVKHERIHTGEKPHSCEVCGKKFRVSYCLTLHMRTHTNVRPYECQHCGKRFKASSVYNHHLLTHGEERAYTCPYCPKTFKTRVQLAGHKNSHTKPFRCTECSRPFASLYAARAHIQTHKQDNNLKFSCNICGASYGRAFALKDHVKQHERDNTLVPPEATREEEVQEVESFLLPTVEEVEDDELIVPSPPACNDPMDVELVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY73</accession>
    <name>A0A232EY73_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001689">
        <property type="protein sequence ID" value="OXU23220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY73"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="46" mass="5368" checksum="DE88A5B5DB004D3D" modified="2017-10-25" version="1">MSGLHHGRLADRRRGQDKAHYARLETRWAAILVTRGAARETRRIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY95</accession>
    <name>A0A232EY95_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit TMEM258</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Transmembrane protein 258</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_006363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001672">
        <property type="protein sequence ID" value="OXU23259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY95"/>
    <dbReference type="SMR" id="A0A232EY95"/>
    <dbReference type="STRING" id="543379.A0A232EY95"/>
    <dbReference type="OrthoDB" id="18408at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13636">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="81" mass="9187" checksum="0314ADE62E123B12" modified="2017-10-25" version="1">MMLEIESMARYVSPINPTVFPLLALVLLGIGIFFTAWFFVYEVTSTKFTRDIFKELVISLVAAIFSGFGVLFLLLWVGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYL7</accession>
    <name>A0A232EYL7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001587">
        <property type="protein sequence ID" value="OXU23514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYL7"/>
    <dbReference type="STRING" id="543379.A0A232EYL7"/>
    <dbReference type="OrthoDB" id="7548341at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="841" mass="96754" checksum="C51ACE05437827D7" modified="2017-10-25" version="1">MIIVEGLKVSWKLYAPYTQWKSHLENPQRNQRAESGTSQPAAALGPHQQSQQSEFVKPAPLAASDPAPIAEEKPVQPVQPVQPVHQVQVQYKPYSMVPTHIKQLILEMYEPQIPYVDPAVYIYRAHHQQQQEEEQQEQAQEKSQAEPQEETAQTSSQPQLGSYSSQYEQVPKYPTKYPINKSKVGYVQYKEEQPTAAASAAPQYGAVPERREAVAEEQSQEQQYDYPQQQRREADDGMPKEIHQLLNLQAMTPYHVIANRIFYKPKNIFVPKPLSEEVKGPYKYRSKIYFVKNDQETEEKEVKERTEREEPVDREEREEPKEEVSEDSIDEIKVVEIEGIIILSLLPFCFGQFSIQGPSDGNRRAQGLKYSADKGVEYTDQAASLGNSGFSIQGASDGNSDFVIQGATDGNSDFRIQGATDGNSEFQIHGPTDGGSQAYVHNYEQQQQQEPQQPVHQSRAIEYKDANGHRVNWRSYNRAAAKPQQQEQQQYEEPAPRPVHRRPSHRRTQAQAAAQQPQAAPQQQQRLQYGSPVANINYNPIDKAPPSIQEILQFQAQIPYVNIIPEHLRHDALEAAQAQAQKFAEEYPKQVLAQHPPQLVIEEAPRSQYRSKPRQHHQHQQQQQQREQVRERRQATSYDAYYQERLQAFARQQQQQQQQAYARPEGQQRREAPHPGQYQQQLHEQAQAYLQQEQQQDQQQYVPAPKAYRRVEQPPAEPAPQYSGNVPSQIQEILRFQAQIPYDVIANQIIYRLDKPYIPQPVQPQEHSQAPQPVATQYKPQAAEYQQPQYEQGAGAAYAQKAHQQQLQEQQQGQLSYAQSRSLGYYGHQQQQEADPRERQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYV8</accession>
    <name>A0A232EYV8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001533">
        <property type="protein sequence ID" value="OXU23666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYV8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="49" mass="5480" checksum="C98439B65A84837B" modified="2017-10-25" version="1">MRGMRLQGLNNVALKTSQKEASSLHPSLIYANVDRLTPHSDHLTKLLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F195</accession>
    <name>A0A232F195_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001366">
        <property type="protein sequence ID" value="OXU24227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F195"/>
    <dbReference type="STRING" id="543379.A0A232F195"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="472" mass="54913" checksum="84B87E04645B9326" modified="2017-10-25" version="1">MLQELVQQIEDDEDFVFDLYQRIKKGYPNLLEKAYVELLDSELSKEDIAKEFDNAGIDFALIVGLDDIELIRIMIKKGINLNSEEEEFKALNVACHRLHYDMVQLLLQNGAAVNVSDIDDQTPLEAVYDSIADEEYVLSVEDDDQDIDFKLTELLVSYGAKLDFDGVIDTYVLEKAMLFANVETVKLLVNEANGDLKVRYNGGCSTLHTAVHSNRRSMLEYVIEVFKRDKLDMNPQNNLDSDTPLHLASFSAQNFDSIAMLLEAGADFRIKNNERLTPFDMLLRGLPDETLAWIYYDHGFDILDCNEVLLDELWRSKSPWMWILIIELAKRKMMGAQFSHKKAKVFKWFDKLRYAEKCTEQLQIMQNTKFYENVTFWDIIIADQHKLKEYANNFDLLREFFAKKCNKSFSLYCTHTRSKLFALLPLSVQIDLATPVVCAAMKMPTMYEVMRYEVMPYMNGYDLRRQLYCCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1M0</accession>
    <name>A0A232F1M0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diuretic hormone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_005838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for the insect diurectic hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001332">
        <property type="protein sequence ID" value="OXU24327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1M0"/>
    <dbReference type="STRING" id="543379.A0A232F1M0"/>
    <dbReference type="OrthoDB" id="6022368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008036">
        <property type="term" value="F:diuretic hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15263">
        <property type="entry name" value="7tmB1_DH_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000155">
        <property type="entry name" value="diuretic hormone receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002001">
        <property type="entry name" value="GPCR_2_diuretic_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF15">
        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01127">
        <property type="entry name" value="DIUHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="53"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU24327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="433" mass="49516" checksum="7CF4FF6FC8A1384F" modified="2017-10-25" version="1">MDFAIVRDAWKGRENATRWCWPNGTWNGYTNYTQCKELYVPELPIDSSGVELTTNLYLVGYGLSLSTLIIAVVIYLYYRELRCVRNIIHTNLMFTYILANFLWILMIVSQVSLDRNIPMCIIFYSMYHYFQLTNYFWMFVEGLYLYVLVVKTFSGDIIKLKTCLFIGWGIPLIVVFIWGMVRALAENSTEAESANEALSNHCPWMIPNPYDWLYQVPAILVLCVNVIFLFMIMWVLITKLRSANTPETQQYRKAAKALLVLIPLLGITYILMIAGPTEGQIANVFANSRAVLLSSQGLLVAMFYCFLNSEVRNAVWHHYQRWLAERSLGQHPRYYAQYTPRSRTESIRFCSHPGAPGTGSSLGPDGCANHKHYDNQENSIHEHSSIVHTIEIHQEPRRMMSDSNCITTVVAVHEEPTAASAAATTYCEPGRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1S8</accession>
    <name>A0A232F1S8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Zinc-hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSAR_014049</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Alberta</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001286">
        <property type="protein sequence ID" value="OXU24483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F1S8"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="21">
        <location>
            <begin position="641"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1315"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="192"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="417"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="716"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="972"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1056"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="1321"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXU24483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1364" mass="158691" checksum="E83EF7D2DFBB35B5" modified="2017-10-25" version="1">MSRIKDLEIRGIRNFGDERAKVLIHFSKPLTLILGPNGTGKTTIIEALKFVTSGEYPPDSDRGKSFVHEPKLTLNHTVRGQVKAKILDKSGQELVIIRTMQVSRQKTGALKFQALDNTITRLDERTKDKIQITNRCSDIDREMLAAMGVSKPILNYVIFCHQEESNWPLEDGKKLKDRFDEIFDTSKYNKAMDTIAKLIKDLNSEINTLKAREEAFKEILNEAEDQESKLRNNEQREKEVQDKITVIDQSVVPLEERMKQILDVKADYQKLEDQLNKVETDYKVTNNYIESLKKHIKQLHTGSKEELVEKLDSYDQNLTQKVTIKKKSEEKLEETERCENTLLKKLADARIKLGSLTQKKIAFYEKITKRNELLKKAFKTWEIPQVDSVTEEGKAKDYIERISRKVKEFSIAMKKRAQEFEQEEKHVQREVDACRSEKTGIDSEMSLKEKERGEIKLEINTLRKKIKQVDEDGGRLDSLEADLQNATENFNTVVQNFDEKSIRETIEREASNKKEFNNQLNNIDNEINFLNKQSSQQAELELHQNSLLKKEEEISVLRNKNESNLNLLFSNAIPQQKLKDSLEKIQKSLSAEKTNLLKQIEEGQQKFTTYKTTLKHKESELSKTVSDLEASKAKVAFECQENDYDEMLALQERKVKALNDQRGIYASQSSMYEEYLKILKKKSCCPLCDRGFQNSSEENSLEQKLHSEIRKSPQALKNCEKELKQEQARYDALQQLKPVRDQIREIENNKLPKLRTDVEKIKNQLQDSEQSLETLRLILSEPEEKLCIYKSIIGDVILLDSYMNQRDHLTQTIETKKREMARAGKVSDRTMQEAQDERQKLKDRLSAIERNVDKAQLALQSGQEKVSRAREQKNKLNEEVLKIRQGQQESSQLKDKVNDLYKKETSLENSLKSLRQNLVIADEELESKVQELNDLKQKNREKQESDLNFKSISGTEFHELSTVQKEVQEVMDSKLEENLEKIETDVEKTKTECDKMKAEKARLEEHIRFLDEQCRSQEVGKKDLENNLDLIKKQEFINDLNIKITKYRTTLENMQFNKLRKEYQELQEKKDKFEKEKSEYKGALGELGIAIRNYKKSLNQEKYRMARHNYKEKQLQVVVQEEAVKNLKEYVTVLDKAMIQFHEERMNTVNKIMRQLWQLIYSGSDTTSIQIRVQTTEGIGDKKRSYNYKLVQVKRSAEMDMKGKCSAGQKVLASIIIRMALAETFCSDCAVLALDEPTTNLDDENATNLAVTLSKVIQLRAQNHKNFQLIVISHDEKFISSLSNLSGKQMFQELYRNPEGYSLVKRRDMSDYIKNSSQSVADDDYDESEEEQEQAIETKNPKKRNLTMDDSPPHGRAVKRRAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2D8</accession>
    <name>A0A232F2D8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_008044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01001239">
        <property type="protein sequence ID" value="OXU24638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2D8"/>
    <dbReference type="STRING" id="543379.A0A232F2D8"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375828" description="Carbohydrate sulfotransferase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="334" mass="38352" checksum="08DFEEB81ABA94A9" modified="2017-10-25" version="1">MKAWAVTIVAICALLWFVGVCAQEVWSVIGNGDDAKEIEPDESLYAWSGSNALARSTLLDRQERLQYKCDQMSRDRSLEPIQDPAEFRNLLVDEKHKLLYCYVPKVACTNWKRVLMIATGKWKGNSPIEIPADLAHASGTFLRLSNFTIPEIEEKLAAYNKLIVVRHPFERLLSAYRNKFEAKRERSSAYFQSRFGRKIIKKFRPNATKESLLKGDDVTFGEFVDFVTKSNEYGTRNEHWNSISELCHPCLVNYNLISKYETLAEDATEILERIDVGSIPFPVRPQNSQPTSTILDKYYSSLTLSQLRDLAELYRSDLYLFDYSLEQILGFSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2N7</accession>
    <name>A0A232F2N7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multifunctional methyltransferase subunit TRM112-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA methyltransferase 112 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001205">
        <property type="protein sequence ID" value="OXU24748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2N7"/>
    <dbReference type="STRING" id="543379.A0A232F2N7"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7265" checksum="48113E6FC2E3D5D3" modified="2017-10-25" version="1" fragment="single">VGYAGDLPPQLIQDYENNEEFLKKMHHVLLEVEIINGELLCPESGRKFPISDGIPNMLLNEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Q6</accession>
    <name>A0A232F2Q6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001126">
        <property type="protein sequence ID" value="OXU25044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2Q6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10906" checksum="F7EB292805E01D54" modified="2017-10-25" version="1">MLLFHRVYFLRNYRELAKFLFTTARHNIAKVNFSLYSDIYILNTNSKALNRTVIIHIFGKYGGGKSSRYTYIYIYIFMYIKAASVFRSCLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2S9</accession>
    <name>A0A232F2S9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_000902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001120">
        <property type="protein sequence ID" value="OXU25064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2S9"/>
    <dbReference type="STRING" id="543379.A0A232F2S9"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032679">
        <property type="entry name" value="Sin1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05422">
        <property type="entry name" value="SIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sin1 N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="136"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="312"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="465" mass="54086" checksum="560FD4C077A76A32" modified="2017-10-25" version="1">MALYDNPHWLLSHIRDSFISTDDTGMCEMVMVRDDIPKDMQSSGTLYAYPGTEDSDEEDLDAMADSYDIQMDMEFSHRQRTNTAQRLEKLDLERKKASKVKHIKWENNPTSITLEQQKELFKGKDFRNNRQNIQRKSLFTEQLEKCPELPQNPFIEYARFDGNSQIGAPVRKYRIFMCMLPKDQRSYPLHVVVLANAKVQQFIGLICYKYISEHPDHHIHEDISKYGLYITEDDGEVDWDFPCLDPTEVIAKFEFSTLGLVEMKPSDKARHSTVKTITEQKKENEKLEKIQEEVAKDLAKMQGHTTAMEAPLYQLYRVYIINKVRAKTEIHLGISGEKIEIDPVITGKGASRFWHRQRAVSYHMDNVAWCELTENKGSKTTFTLVYTPHTSITLDGLNVSISHTQSLRRSASFKNHDFEAESTTAEEIVRKINHILELRSSSSRKEYIAQKERKASRRKSFHIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F335</accession>
    <name>A0A232F335_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001163">
        <property type="protein sequence ID" value="OXU24929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F335"/>
    <dbReference type="STRING" id="543379.A0A232F335"/>
    <dbReference type="OrthoDB" id="5949187at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031751">
        <property type="entry name" value="DUF4735"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33539:SF1">
        <property type="entry name" value="UPF0764 PROTEIN C16ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15882">
        <property type="entry name" value="DUF4735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669402" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38727" checksum="D141CA314342BA03" modified="2017-10-25" version="1">MDVKLIFLIFLYICSITHQVISAKFDTNKFERKMLALMKVLKYSIERPEQMNMDTTFGVTFAQANIQAALRHKNVMYLDTYQKDVLENLLELSEDTRNLLHTYEKLPNKNVQELSFQLNRPEIWIKPIVWKKLDLTDKPLPNPDLTVDETVESMFRGHPQEAESDYCFINLVNHCEFPNECRDLIVHNDNATTGYPLTHRLLMIQLMNALGCETKITQFTPYLVYEFCSLILQDLVNLEAMGFPHVGKDLASEQIFLCGMEGYLDFLNEHYEQLLLDWQHPSGCYSGIGHSVDYNWAKTRVRRSGGFTDFGCVNHATGLGAAALALLIRKDIELMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F337</accession>
    <name>A0A232F337_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ero1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_007961</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001180">
        <property type="protein sequence ID" value="OXU24837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F337"/>
    <dbReference type="STRING" id="543379.A0A232F337"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU24837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="56047" checksum="6BFD874E57063E3E" modified="2017-10-25" version="1">MHGFRDNEMMGGRDRVMQRPTTMLLLLIAVSFQAVSGNLFGTNRQRTDDQCFCELNGAIDDCSCTVDTVDYFNNVKIYPRLQSLLVRDYFRFYKVNLKRDCPFWADDSKCAIRFCHVQPCQDKDIPVGLKGELPRNIHVNESPSDKYKANMQISDCDQNNHDHNIELGYLNTTISSENYKEFERWQQHDDAQDNFCVTETDTGEYVDLLLNPERYTGYKGPSAHRIWRSIYMENCFRPDNSPHTFIQSSKVDDMCLEKRVFYRAVSGLHSSINIHLCSKYLLSSQSRLEVAPEGQWGANVEELQRRFSPETTGGEGPNWLKNLYFLYMLELRALAKAAPYLQRLDYYTGNEVEDSDTRLAINDILNVVRTFPEHFNESVMFNGGVEAQVLKEEFKQHFRNISRIMDCVGCDKCKLWGKLQIQGLGTALKILFSGKFEKYEPTVLTFSKKHFFLERSEVVSLINGFGRLSESIFELEKFRKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3F0</accession>
    <name>A0A232F3F0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001110">
        <property type="protein sequence ID" value="OXU25102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3F0"/>
    <dbReference type="STRING" id="543379.A0A232F3F0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="228" mass="25185" checksum="0E9123BF06B8EBCE" modified="2017-10-25" version="1">MTHIQFMLYFRLNGLEAESIVSGENATIGQFPYVVSSQNAGIKFPEAGTIDLQSLTKKIEVEKIYKPKNFEYAKYESEGFREYYISDIAVLKLKKGLILSSNCNLSKLELPKKPYSLYVDDKAVLAGFGYISVDVAVDYTTRELYETGGTVDDKLHYAETKVITNDECAKGFGFEPVDKDGLCARIEQGDPNKPKELCNGHSGGPLVYNDTTVIGIAVSSPMACNETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F408</accession>
    <name>A0A232F408_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_015237</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000996">
        <property type="protein sequence ID" value="OXU25566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F408"/>
    <dbReference type="STRING" id="543379.A0A232F408"/>
    <dbReference type="OrthoDB" id="411630at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF46">
        <property type="entry name" value="METABOTROPIC GABA-B RECEPTOR SUBTYPE 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="449"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU25566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="854" mass="94098" checksum="491E958F151B38AB" modified="2017-10-25" version="1" fragment="single">CDPGVAVDRFFYALYSPKKSVLMPLLLGTACSEVTETLAKIVPYWNIVQVSFGSTTPALSDSTEFPLFMRTVAPDSSHNSARISLIKHFGWDTVTTLSQTGDMYSLAVNDLVTELEQANITCTATITFAENDYKDQLFTLKELDTRIIIGSFSPQLAPKVLCEAWRLGMHGGDYAWILPDDTIDLSGMTGDWWHAGPDDCSPSQLSQTMNGMIIVKSHATVFGDDASYSGLSSPDFTTELAKKGVSVSRFAAQTYDAVWSMALALKRTEYILNKKNMSMTQYNHTRRDLAVKLLKQLRRLHFVGVSGPVSFDGADRVGITAFYQMQGHSIRRIAVFTPEDRELIMNCPGCAATRWPGGHPPAARRVFRLRIVTVAPAAFLAMACLASVGMTLALAFLAFNLHFRRHKSIKLSSPRLNNMAAAGCALVYGAVILLGLDHATLPDSDGYFPAICTARVYLLSAGFSLAFGSMFTKTYRVHRIFTRSRSGVVKNKLLQDTQLISLICVLLLIDGLVVTLWVTLDPMQRHLRNLTLEISPQDRAVVYQPQVEVCRSQHTNGWLGALYVYKGLLLVVGVYMAWETRHVKIPALNDSQYIGMSVYSVVITSGIVVVLANLMSDQATLAFVTITSLILASTTSTLALLFLPQLAHILAGERADPVVQSLGLKIECNTRRFVTDDRRELQYRVEVQNRVYRREMAQLELELARLEKQLSQDPVDPSHVSSSASIPQRNPSISGGLPMLLLSVLPPVIPRASWPSANPSSMRRGTVAFSSQPDLEPNGPRRSLADIYRLHQRRETEGPNRLGVFQRLFSLFGSRPNSRKTSTASFTGVASALRVHMGYIAGLVPGTKAASSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4A8</accession>
    <name>A0A232F4A8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MANSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001060">
        <property type="protein sequence ID" value="OXU25300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4A8"/>
    <dbReference type="STRING" id="543379.A0A232F4A8"/>
    <dbReference type="OrthoDB" id="10037294at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011106">
        <property type="entry name" value="MANSC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46876:SF1">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07502">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00765">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50986">
        <property type="entry name" value="MANSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012330637" description="MANSC domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MANSC" evidence="8">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="154" mass="17905" checksum="90B81C1AB97BEE7C" modified="2017-10-25" version="1">MRQRLLVIFVLVSCCCCCCYSQDVNGQLEKQETVMGLQTCIDGFVVHRDKIIRTQDSRDMGAKYLTEFDVESRIECMKWCCETEHCDVFIFEEKKPGSCYLFHCGPPHDFKCKFTSHANYSSAVLTVNYNLQNAAALEEQMRHNQQEHELKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4H0</accession>
    <name>A0A232F4H0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Testis-expressed sequence 9 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001042">
        <property type="protein sequence ID" value="OXU25378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4H0"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="38430" checksum="B9D0CD9E0EBF7CA3" modified="2017-10-25" version="1">MSNHSLLNKERDFLELNKELEDKVKSLMVEVDTIISKQEDVIRSPRRPSYMRSRRYKSKLKESLPTTESDEEQLSDSNDDYDDDHVPVEAFLKNGNFKERTSEEGCDYDDTDGHDGSRKKKKRSTKETIIRFLKAQVTKLQADLQAAQYESKKKTESYKELEGEIKKHEQKREKLQNQLASQKETILKAEVSNNELQARIQTQNAEIVSLKKEIENLKKDLKSLNQISSNSDLRLNRSLEENEKLRSSLRTSQAEEKELREQIRKLQEEKRLALKNAEKQRTDIFQAFKKQTQLVDNLKKQKVGLSRGKQRNSVHRGRLYETIGMETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-05-29" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4P9</accession>
    <name>A0A232F4P9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000953">
        <property type="protein sequence ID" value="OXU25751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4P9"/>
    <dbReference type="STRING" id="543379.A0A232F4P9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="135" mass="15917" checksum="BD3578D0AE31EE21" modified="2017-10-25" version="1">MCKAHQLKHDFFTPETLTEICTKLVTHYFVLTPTDLDSWNIDPENFVLVDLIRRHHQPVNPNDLQNVLLKDAVYNAVGLAGFDLYDEVNFDEWFSTTLKHELNQQSHNHRIIRRRVCWLIGRWTGMPFLSNIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4Z9</accession>
    <name>A0A232F4Z9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhythmically expressed gene 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000997">
        <property type="protein sequence ID" value="OXU25559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4Z9"/>
    <dbReference type="STRING" id="543379.A0A232F4Z9"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29773" checksum="45EE9FEF1449CBD7" modified="2017-10-25" version="1">MRLPIPRLITFDVTGTLLMTKLEQHYVEAAASHGLDRIDVPRIAKAFKTNFKRLENEHPIFGKSTGLGWQNWWRSLVHEVFRDQDRAICSEKLDKIADSLIECYSTSRCWHKYPGTDELLESLSRRRPRVVLGVISNFDERLEAVLDDARIRSYFSFVITSYGLGVEKPSPAIFQEALRLSSIDLNETIRPDEAIHIGDRVDNDYLGARSANWNAILINREDDPIDEKVVDPRDVFRHFDDLKTHFDSLLTRNAAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5B8</accession>
    <name>A0A232F5B8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000897">
        <property type="protein sequence ID" value="OXU26026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5B8"/>
    <dbReference type="OrthoDB" id="7550839at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895590" description="SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22369" checksum="546800FAEA7DD47A" modified="2017-10-25" version="1">MKPFFTLFTLFVMARLQISQAKPYMYDDLQPQPRSNKQTDIRNKNVNIIVNMDPKQVAAELWNVIREHLGSTSPQEAATTMREIEAAISPVMMPSRRGGTIPAAQVADDLESITRRLVLHENPNIDPIRMEVLIKEVSTDLLSSLQSIWNGVDTGAQSFRKSIDTNDDDEKDNNGKDEYADLRVKVKKSDLAEIVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7D6</accession>
    <name>A0A232F7D6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000728">
        <property type="protein sequence ID" value="OXU26776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7D6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012421015" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="51" mass="6014" checksum="6C48E703EBED9BBB" modified="2017-10-25" version="1">MAAAARRSCHLFFVPSLLCRLAATRWKNKGLKESFHRRSDRLRRETMTHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F855</accession>
    <name>A0A232F855_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000791">
        <property type="protein sequence ID" value="OXU26487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F855"/>
    <dbReference type="STRING" id="543379.A0A232F855"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234840" evidence="9">
        <location>
            <begin position="22"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="11">
        <location>
            <begin position="175"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="634"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="758" mass="86844" checksum="D91021E7B63BE954" modified="2017-10-25" version="1">MAFIGKVVLLIDLLIVVRVLSDNCVIPWMETGHEVAESEYVLDLSIVNTTGHLRSYFPDTQYDITIRSKFRNQTFTQFYFTMSNKNKTMSDGRLTLREVQLSMFHNDMPFCINRVIDGPISLAKQTLKIGWQSPPRDSGCIELKAAIKETDLRYHVANLTVCQDPRVELDDPGQILRNCCACDEGKYELAFEGLWSRYTHPKNFPRREWLAVFPTIIGASHSHDYEFWHPYTNASDGLKKYAENGETTDLELELKANMANITTLLKFRGVNFQNKTRQSYAGVRVTRDHHVVSLVARIEPSPDWFIGVSSLELCQPDCTWAKQKTLNLYAYDVGVRDGTGYENQGDFTDPADIINSMNMTWPPPVWKDDALVESPFYDKTNNTHDVRPLAKIHFTRRAGSEKSCKKVGATHYMEPDCVNPWSAWDPCSVTCGIGVERRNRTLKKNVKEEDCPVELKQSRTCNIKQVPCKKELTLGDCVLTEWSEWTKCLDMCGQESRHRSRTYKWTQNAVQCIETFGQKVLQQEIDCGHPPCPDDRPVCMDHLYTDWQLTPCSATVGEGFRIKYRTLKPNPNNLLGTETDYPACRYQEVECTVHLPRSHDVVPDHQDKDEEAESPKIPQVDYPLPEIPITEDHCSMPADIGQCEDGHNENSLRHYYRMDRDDCAIFSYTGCGGNKNNFKTKKECMRECSPEAKDVNCVMSPWSEWSECKSCDGVQYRQMTIIVPPRNNGRACPLDTVEKRKCTEKCARNAYPNQEGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8H3</accession>
    <name>A0A232F8H3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="13">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_016769</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01000731">
        <property type="protein sequence ID" value="OXU26769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8H3"/>
    <dbReference type="SMR" id="A0A232F8H3"/>
    <dbReference type="STRING" id="543379.A0A232F8H3"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007424">
        <property type="term" value="P:open tracheal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09934">
        <property type="entry name" value="SH2_Tec_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11768">
        <property type="entry name" value="SH3_Tec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000190">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="87"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="203"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU26769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="464" mass="52956" checksum="556210CB334ED187" modified="2017-10-25" version="1">MPGGTPGTPSSKAKEKLMIRSKVVVALYPFRAIEGGDLSLEKGAEYEVLDDSQEHWWKVKDEHGSIGYIPSNYVKEKELLGLQKYEWYVGDMSRQRAESLLKQEDKEGCFVVRNSSTKGLYTLSLYTKVPHPHVKHYHIKQNQRGEFYLSEKHCCGSIPDLVNYHRHNSGGLASRLKASPCDRPVPPTAGLSHDKWEIDPAELHLLEELGSGQFGVVRRGKWRGSIDVAVKMMKEGTMSEDDFIEEAKVMTKLQHQNLVQLYGVCSKDRPIYIVTEYMRHGSLLNYLRRHETTLGSNVGLLLDMCIQVCKGMAYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEVFTCGKMPYGRLKNTEVVERVQRGIILEKPKACFKEVYEVMRKCWAHCPEVRPSFRVLKEQLINVSQGLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9V2</accession>
    <name>A0A232F9V2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_008392</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000669">
        <property type="protein sequence ID" value="OXU27087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9V2"/>
    <dbReference type="STRING" id="543379.A0A232F9V2"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218132" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="321" mass="36318" checksum="3FBC53A263405730" modified="2017-10-25" version="1">MYRRMFALCYLLAVRNWIVAAAAETTPPHIIFIVADDLGWNDVGFHGSGQIPTPNIDALAYSGLILNRYYVSPICTPSRSALMTGKYPIHTGMQRGVLKGAEPRGLPLKEKLLPEYLRELGYRTHIVGKWHLGFYTKEYTPTYRGFESHLGYWTGHQDYYDHTAVEEPYWGMDMRRNMEPAWDLHGQYSTDVFTKEAVKLIKSHNASQPMFLYLAHAAVHSANPYNPLPVSDEIVDKIKIPEYKRRRFAGRAGMTSAMDASVGSVIEALDKRNMLRDCLIVFSTDNGGPAEGFNLNAASNWPLRGVKDTLFEGKYRMSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA84</accession>
    <name>A0A232FA84_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Guanine nucleotide exchange factor DBS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_000067</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MCF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000622">
        <property type="protein sequence ID" value="OXU27343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA84"/>
    <dbReference type="STRING" id="543379.A0A232FA84"/>
    <dbReference type="OrthoDB" id="10004999at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11856">
        <property type="entry name" value="SH3_p47phox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF211">
        <property type="entry name" value="LD43457P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="12">
        <location>
            <begin position="87"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="623"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="806"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="975"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU27343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122564" checksum="D76503EF55BFE3BE" modified="2017-10-25" version="1">MNFQEDKLAKMAGSPTSIENQIDSFLEQFKRSASRAMEEHHRRSSIYNASSISRSRSGNLDLEVLEAEDVESMTGEIENGELAVRDVADLLQPQYAIVTGGKTREGCPIITFPDNGNFHNLTDLDYQRLMLYLTSVPTLHEADLGFHLIVDRRTDKWNSVKTVLLKISAFFPGLVHVVYVLRPVGFLQKAISEVSNKLFREDFKFRVIVLANVFELHELIEKDQLTEQLGGELAYCHHTWIQNRISLEKFSSMTQDVSLALDSFTRRLAEVEFPNNTIATTTLLSQQQAEYNELKEEILSAARHGEALLDSVRQLTGKATADRLGNVAAVERLLVQLEETERTFDLFWSHHSSRLRHCLALRQFEQDFRELQANLGQHLKTIEEMTEVGETQSRVDQLLRDTSTFQRICRGDIDRAEEVITAGQQLLSGRHQCPAEVVEPKCAELQRVCTILSQRLERRLHTLTKCRELMEHIDKANTWCTRGIELLAAQNSSTPADQALQELQSLIEAAEEFHHPRSIFEDSIMPETKALVTQVLQRIEDVSVMCDKRIMSLKQQLMKPARPIQTVTPEPAKPLQPAPQCIRPGRILKKANTMPRMEMGPVEGGEISSPESEPRDGEALRLKRGHVLTELVETERIYVAELGSIIKGYKMEMNNEALAHLVPAALVGKGDVLFGNLEDIYLFHRDTFLRDLENCISNTELVALLYSYYCQNIPRSERLREQIQSEPQFLVTCQQKLGHKLPLAAYLLKPVQRITKYQLLLKDLLKYSDEQSCCVELQEALDCMLVVLKCVNDSMHQTAITGFGGDLNAQGELLLQGSFSVWSSSKRERLLRLKPSQRHIFLYEMAVIFCKHSKPQAHTKATYHFKRYLKTSQIGLTESVKGDARRFEIWLQGRAEVHTIQASSIDVKQAWVRQIKNVLMSQLAELKGKQNTALLGKTGHKYGPLRQTISWDAQSSLSGSLRTLSVDSNSMVSHLTDVSQSTENDDVGWSSENSNTDDEDAFGDIAGPAPGGRYVALADYCAMGQSEVTMREGDNLELLKVGCAGWWFVKLIGAGIEGWAPASYLEPISRKTCRSSQSVNSSQEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAA4</accession>
    <name>A0A232FAA4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_013853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000614">
        <property type="protein sequence ID" value="OXU27389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAA4"/>
    <dbReference type="STRING" id="543379.A0A232FAA4"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22297">
        <property type="entry name" value="PSMD4_RAZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049590">
        <property type="entry name" value="PSMD4_RAZUL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="383" mass="41921" checksum="CEF30652DCFD34B9" modified="2017-10-25" version="1">MVLESTMICVDNSDYMRNGDFLPTRLQAQQDAVNLVCHSKTRSNPENNVGLMTLANVEVLATLTSDVGRILSKLHKVQPNGNLSLITGIRIAHLALKHRQGKNHKMRIVAFVGSPIQIDEKEAVKLAKRLKKEKVNVDIISFGEESVNNEVLTAFINALNGKDGSSSHLVTIPPGPHLSDALISSPIIQGEDGTGGAGIGGAAFEFGVDPNEDPELALALRVSMEEQRQRQEDEARRTQPDVPAPIKEEPKEVSNEEAMLKRALAMSLEGSEESSVATESTAPSSGSVPDFAHMTEEEQIAFAMQMSMQDQQELEGPQKEEPMEVEEDYATVMSDTEFLQSVLENLPGVDPQSEAVRQAVGSLQQNKDKEKEKEKDKDKNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAJ0</accession>
    <name>A0A232FAJ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">OAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000527">
        <property type="protein sequence ID" value="OXU27864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAJ0"/>
    <dbReference type="STRING" id="543379.A0A232FAJ0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043562">
        <property type="entry name" value="RAX/RAX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="8">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21855" checksum="218677CE81DDD785" modified="2017-10-25" version="1">MTYAMLHKIKKKYKNSYENYKKRIFSLQVWFQNRRAKWRRQEKMEAARLGISEYHAANAMRSVAGPALGLPGDPWLHPGVLNTLPGFLTAPPAGYASYLTSPRRLPLTPACAGTVLDEGTLSETLSGGMARVASAGHVGQPPASPPGGHDPRTSSIQALRMRAKEYVETVSKNLQQQQLQRSSPPGLQANRDDSFVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBA1</accession>
    <name>A0A232FBA1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000517">
        <property type="protein sequence ID" value="OXU27902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBA1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="157" mass="17271" checksum="C5C3B9A1F4623543" modified="2017-10-25" version="1" fragment="single">MSVSAQTDQRKVHCSCIGYRYSKKRQSTRNGKTTEGAKACPRESNIDSSSSIAIRIAETQVSSNVPARTIHSSHAGISVRGRQFCTHVDVDSLLRVDLRAVVDAVLGIVAEELVLVLVPLDRVERAVPGGKFPGALEVHRMPELRFLRHVYVDFDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBF0</accession>
    <name>A0A232FBF0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000537">
        <property type="protein sequence ID" value="OXU27810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBF0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15695" checksum="D797B66430E01A1A" modified="2017-10-25" version="1">MKSGVRDAEQGLLHYANTACLLGISRLGTGIWYFSCLLSTSYLEIRSKGLGMTRFGANWSNLVLCFLSGDIENHILRTIDREHKKIYIQRVTICLNRKRIYNGDIRIFVKLERLSLIDFLICLTVYLPTLTCIEICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC54</accession>
    <name>A0A232FC54_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000436">
        <property type="protein sequence ID" value="OXU28406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC54"/>
    <dbReference type="STRING" id="543379.A0A232FC54"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="249"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="497" mass="56949" checksum="116A1F57034CBF0F" modified="2017-10-25" version="1">MGVQGKTVEAMEVEVSNPEAPNGEEVEKKDVDLITIHDLREHTRQIEKAVLNKEPRFILRALRALPNTRRKLNPIVLRGIIGGFYTKSAAEKEALLAWVEEPMDMEGTQAAIQRFKSSATPLLPEIDAYIHLLVLVRLIDTKKYTEAVQCSEALVQKIIAQNRRTIDLIAAKCYFYHSRAYELTNQLDKIRGFLHLRLRTATLRNDFEGQAVLINCLLRNYLHYNLYDQADKLVLKSTFPETASNNEWARHLYYLGRIKSARLEYSDAHKHLVQAMRKAPQTTAVGFRQTVQKLAVTVELLLGDIPERQIFRQAALRRALAPYFQLTQAVRLGNLQRFGEVLENFGPQFRSDHTFTLILRLRHNVIKTAIRSIGLSYSRISPTDIARKLGLDSGVDAEFIVAKAIRDGVIEATLDPENGYMRSKETTDIYCTREPLLAFHQRITFCLDLHNQSVKAMRYPPKSYGKDLESAEERREREQQDLELAKEMAEEDDDGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCX0</accession>
    <name>A0A232FCX0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000451">
        <property type="protein sequence ID" value="OXU28299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCX0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="53" mass="6091" checksum="D8032C404B2247D9" modified="2017-10-25" version="1">MVATAMHSTTPQELYDSPAIYHRSYDISDGLYRVVAVYSFRLVERRQGHCVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD48</accession>
    <name>A0A232FD48_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rotatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000408">
        <property type="protein sequence ID" value="OXU28605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FD48"/>
    <dbReference type="OrthoDB" id="428850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010457">
        <property type="term" value="P:centriole-centriole cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032053">
        <property type="term" value="P:ciliary basal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030791">
        <property type="entry name" value="Rotatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029249">
        <property type="entry name" value="Rotatin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691:SF1">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14726">
        <property type="entry name" value="RTTN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rotatin N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2129" mass="242881" checksum="AABE5378D1831F56" modified="2017-10-25" version="1">MSTMCTISNTHIKKLDHALGEIRLRALENIISKLNLGFECDCNAVKKELLIKLFKWFTIEPIIEEEKVLNLLIKLLKSDSGSYLNSFGKIRLQNELRDLRARLDSKWHDKLNVMEEIVSKPDQFIQHFEDVPPLVYEPSEINYNQQYQNYPSESSSFTAMSPLDCSAPFELTVNCGDGAIIPRRSESSVKWLCMPWQVLAKSDKNVLTSLKNSFNDSPDIATKIESCRFITNILLQDFPAEVFLQRPTTVNILLDLLQSYKDEPSQEGRINESSENLIIEILKILYKLTRSLRFRIYYYCDPSIAHKAQKILSRNLQNQDFGLPERDSPDGEPPDQNYHGFQTTRPGNRSPSVIDDVNDSVLQLQQKFIPHYCTETLIHVLKLLSIPNNPTRPLKIVRLIADLAYELVQLLITSVMPTVWFCNDNVALKIHDNVKTLFEMLGEILDYFEQFNSVDYYRTTYIFFLWISVKLISNIMPLELADQVIPKNMKLCICNAIMDAPIYLMYSSLHVTLQEYARRFHGTQECAAVKLLDETRLVTKSMKAAISLIKFPRDLPYSEELKIMYLSKLSLLYHKNFKMIRKFVSLAQNRAGYSLSTEDKETTTKMILSLLAHNDDDVQEATYTECQNLVAGVLGIENNGRYSWKNLLFLMEPSVLTEIICHGTTKENKKIKSMADDILLHLLKGKFQMGESGWITFLEALIPVLPLLQCLAHPSSNLGKSITKMLDPDISSSIKLPFIEVLKGNIRLLFSPIPDIRDEALCRLLWLLGQEKNASQKLPRLTSLHGLPFGSLCVFDKQTSAKRSEGTYQRSALISVLEMLRSDNIEPKMRKSALVQVSVMLSDSSLHKLFISENGLPLILDIFSKALIEKDFVNYPDSVISIVTILKLLASSEASIRMELSNRIDLYYNVLRSVFLYPNNESVKMDSAQLLALLLYNTYIMRLTERTHNNPFNISLPYLITITMKLPFTCKAHWKASIHRRSDISILHRSNPVALTFIRQFWAWEWNGHEEMLWKKWENINDPMITETLMIRETELACMTNTSLFYCIQQQLYNIQNSIMHNGVMRAIDYLTMYFKLCNLLNYVHFENVARLPWSHTFERFLQCQPTCKEDQELLANLLNFLHLYIKCTLHEDTLWLCKTVKSMMKSLSDWLQSGTDGGEDIHQSMLRLVRACSMIDCKENNESKNSWIFFIKFAVANLDYGEFYNLAFLDWILSTLIYVIGKCQWKNHKDTLVSVGKSLNQLILSFRREGTVTFMASTIVRNCIICLNHVLYQMQINLNKNILMKFWYDEGQALSWLPELWKSRDPLVRASALQLLASLINGPHTSLQLLNAIDLSPGALCHWLLYFVTTQEESCIVKEAACLAMSNLIRNSNSIVFQYVDPLKPSAMLSYIKENNVYHEIAVMCSNYYMLATLDPDMSGSTESEGTQTQSLASSRTGTTVSMVPKTIYYLYNCSEDFQKCSVGNSVNTDDEDQMQFIATPSLITSLCSMLNNLIAIGEHEVIHEIFEHSLHKYIIGCFGDIPKTINGERNLEHYTNILEMYTNLCTVLTNCVIHSPDFASIVIFSPDFIRHLFELLNDDLYFTNNPRLAFLQNQLGTEIFKFLLSLSQTENQHFDSIQTALESCDTESFVKTMCNIIKSSKSDFGMSALGFLAFLLSQEMQKECEENKPMLLKEVLDTKQLTASNGNNELQAASNASKSPTKSARGMMPIEHPTDYNKSVDTGDEVFVGADICKVLVNLFIGFQYTKTAKKSKQSSDKDVVTVALTNLLCVSTEAKKLAITEQFPATCLMVLKEIYVKLNSVPIQTYKSQTDREQKVHPLLHEIDSIYILLMNFMYDSTEAKEVFAKAGLADIIHKLWAHTSINKKVLINTLKLLSTFTSNYLEAAQSLSLTTVTPGVGLRKTPNSVSLMHVIVQLVSKEIEMNNCKCDCQKLNFAFHILRNAIHNHECRFVISKTNLLQFFTKIHPSTTKRTKIWQIVEINCLEFLIDFTFYDEGQLSVSKAVDGLEVLISLARLSTGSSKLLAISILRNLAFNASNRSRLLGSAEFLELLLTSLKEGSSTEIEVAGSTLWSLVSNNQKGKLIARSSGFGHCIQTAIRRLRLQQDGAQEQDLVKMLEYVLQIISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDU4</accession>
    <name>A0A232FDU4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000393">
        <property type="protein sequence ID" value="OXU28690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDU4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="135" mass="15053" checksum="8D752C58DA5BF751" modified="2017-10-25" version="1">MQRDGVKKDFGTEKVTIFGTSLPLFSLGRSYTIHAASQLLALIYFYAFSNRNVHLVVIIHARRAAVAAARLRHFLSCVYALFAPASVCSRLRVKDILHLIHGGEGGGDEEEEGGSCYRAITICQRTFSFRRSRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEB7</accession>
    <name>A0A232FEB7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000371">
        <property type="protein sequence ID" value="OXU28828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEB7"/>
    <dbReference type="STRING" id="543379.A0A232FEB7"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="432" mass="50593" checksum="03390A0FC2E894AC" modified="2017-10-25" version="1">MMDVPPSEQEELFIRKLRQCCVAFDFLDPVADLKGKEMKRSTLNELVEYITTGRGVLTEPVYPEIIKMISANLFRTLPPSENPDFDPEEDDPTLEASWPHLQLVYEFFLRFLESSDFQQNIGKRVIDQKFVLQLLDLFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFVYETEHFNGVGELLEILGSIINGFALPLKVEHKQFLVKVLLPLHKVKCLSLYHAQLAYCVVQFLEKDATLTEPVVRGLLKFWPKTCSQKEVMFLGEVEEILDVVDPSQFVKIQEPLFRQIARCVSSPHFQVAERALYLWNNEYIMSLIEENNHIIMGIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKLFDELTASYKSERQKEKKREKEREELWKRLNELEMERRQTLIAPPTNTPVPASTAPATRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEH0</accession>
    <name>A0A232FEH0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000391">
        <property type="protein sequence ID" value="OXU28707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEH0"/>
    <dbReference type="OrthoDB" id="7699497at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="180" mass="20659" checksum="7E18D176B8F27636" modified="2017-10-25" version="1">MWKLHTTQLSTELLHKAHVALPLPDSFINFNEWLLSDVLRLRTTVREAVREHGCTTLDHSQLKYTHLIPRRSPSSELSTTSSITPKVTLSEGLRICHFNANSLTGHIQIVRLFLSTRLLFHVIAVTETGLNEKVFRMKVDPQKLKKNPYFGIFIHFCSFMGSKTLSGKVYKLKQVKFLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FET4</accession>
    <name>A0A232FET4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000327">
        <property type="protein sequence ID" value="OXU29205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FET4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="52" mass="6270" checksum="D1CD4A9C04F9965B" modified="2017-10-25" version="1" fragment="single">FEFPVHNIEQYDNPLKLSFKCVTVYTNYNPSYKTTCALHNVKLMKLFYQHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEU2</accession>
    <name>A0A232FEU2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_009447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000314">
        <property type="protein sequence ID" value="OXU29281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEU2"/>
    <dbReference type="STRING" id="543379.A0A232FEU2"/>
    <dbReference type="OrthoDB" id="8195605at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="207"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="53668" checksum="B0D24DF83F22C9AD" modified="2017-10-25" version="1">MGRYIRQTTKGNWNPDQLKNAVEAVKKGKKIRACAKKYKIPESTLRRRMKENNLDSPIMGVSTTFTPEQERIIVEYLKNVSGWFRGLNSIQCRKIAFDTAEKLKIKHKFNKKQKIAGKDWFCGFLKRNPDFSIRKPDVQSNEQFQQFYKKELDKFFHDLNLIIEKYEFSPDRIYNVQETEIYTVKVKENTGDKSLNSEVSWERANRTSVACATNAVGSFVPPMFVFPFEDKMQLMKISVPEDAVVECNSNGNVNEEMHLIWLKHFAEIVNPTRSDPVLLILNPHNGHASIDAYEFCKANHIHVLTLPPHAAFQMQPLNATIFVPLKRAYYRECEAYMRNTGTKEISVYKIADLFTKVLDKTASIDKAIKGFKSTGIWPINPLVLDVKKLNRCSKINIHSNAASDGDDSAGQRSSNSNSSDASRTSSSSSEDIDTSESSDSSENSDQDSDLCENRYQTRTRCQKKRKYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFH8</accession>
    <name>A0A232FFH8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_015182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000342">
        <property type="protein sequence ID" value="OXU29067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFH8"/>
    <dbReference type="OrthoDB" id="10029266at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF37">
        <property type="entry name" value="RE36877P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="7">
        <location>
            <begin position="45"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="721" mass="79205" checksum="D06C14E63A968C4D" modified="2017-10-25" version="1">MGKIKINQQQLPIKAHFFFFMAGKYYKLLARLLIIHTTTHDVILAMGPILPYLPVYGKQLGVSPAVMGSITAVLPLLFLVAKPAFGFVVDHFRAWRRAIFVGLLATTSGCYVLMYFLPSLPAPVLPDKGEFFNVSCSTIERCSTMNLMTLSRKNESNLKFYVRIIIQRINVTDSCEDDGRISDCVWICRDAGNFSGQVFFRTSREASFDKHSSCFVSESNSTYCLEDDVCQITCDDSKHESACIYWSLTFLGFVVLMALGNIGFNVSNCISDAICFDVLGEGGQMSYGRQRVWGSIGFGITAFIAGYAVDLWSGNDSIKSYTPSFLLISAFTLIDLVCCSKLEPLAQHAVLRLYAQMLHSLHEYLDVADHVVSEVKLELFLYRLQGTSRSVVLVARDASLVHEQAYVQQRFGSCSTLLLGNLRLGLDFSLLQSFRGVLLRALPAMRPAASRTVLEVDVAPTAVAAEEGDERVHAGTRQVTPLPAAEAPLPVMSGSESILKDVAKLIRVKPIAIFLCFATIAGILDSFVIYFLFWHMEDLAKDTGYMHEIKLIEGLTVFAETIGGEVIFFTFSGKILKKIGYGYSFVCCFVCYALRLGLISLAPTPRWIGPTYALCYTTIVAYASVVAPPGTSATVQGIVAGMDDGLGFAIGSLVGGFLYDSYGGATTLKVYASLAILTAVAYLITHLIYLKHIMPETGTRNKVEWKSPEEAAEKCADANEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHF0</accession>
    <name>A0A232FHF0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_002827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000226">
        <property type="protein sequence ID" value="OXU29879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHF0"/>
    <dbReference type="STRING" id="543379.A0A232FHF0"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="112" mass="12639" checksum="00DABD465B16754C" modified="2017-10-25" version="1" fragment="single">GLFHSTDSKQEIAFRYAVEKINGNRDILPKSRLSAQIEQISPQDSFHASKRVCHLLKTGIAAIFGPQSAHTASHVQSICDTMEIPHLETRWDFRLKREGCLVNLYPHPTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHU0</accession>
    <name>A0A232FHU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_015427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000174">
        <property type="protein sequence ID" value="OXU30311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHU0"/>
    <dbReference type="STRING" id="543379.A0A232FHU0"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="549"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="896"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU30311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="944" mass="109168" checksum="62FABB6A673EFFA7" modified="2017-10-25" version="1">MVQKVYVDKISDIFTAVQYNRTCHQNYMKKLAKYYDKMDFDQFLEEFISNLRIPMCYMEKHPNVENTLQFAAKFAISLQPPQSENEEEYEEMCLLLERLFEFLLAHHEVKEVAVRFRVCYFLNMLLDTMGDNASIDDELCNRILQCMTDRILDKSPKVRAQAAIALHRLQEPNNKECPVIGVYLFHVAKDPSAEVRRVILAKMAKNKKTLDAAIKRTRDVDDSVRKMAYLFISKITVKSLTISQREQLINNGLQDRSDVVKKCVREILIPSWLRYYDQNYINFIKAIDAEHASETASLALGCLFKNAEIPYLIDQLPLDSTKFVPLEQLTSEVVLYWRCLAEFLKTENYTEEFEQILPELTPFCAYIKDFVTLTEARSNKQYEQVTQQFILYQLFEMIKLYDLADELGRRNLKELILETLQTYNCSNKISECIVKYFENVVPDVNDRVALLVEVINEIRMPTRTNLVLPMSDDERHERKMKQSKLAMQLLEIEDLEYAAIQRKDYTEAAALSKQAASITEEIRNLAKEPEILESQTPCEEKTDPETMIQCLQIMYYMMQSSTITTLSPTLRTLMESIALPYVSLQNNHEQVLSLALKCVGLCCHSDKDLAKKYFMMYCLYISESTSDDVWIAATEVIFDLLLKFGFEHFDITPDEENNPQNGNKRNRSVRLYSHNDEDINVNDKQIRTVDGSNNVIKVLMALLDNQVENLQSVATEGLCKLILHKRISSHQLISQLLILWHNPSTKSNPTLSQCLCNFFNLYMSKVSESQAILEEAYLPTLKMLANAPEMSPLQEVDALRVSEVIIGLTCCAIHNNYSTHNQLTYTILNEILNPDTEIELDVLIKSLKMLDVQLDGQNLKNDILKALDDAEDLLNGSGEKRLLRYIHQFREKITTNRIDETAQSENPENPGHSNNQEENVENAEEQDQDEDEEEEQDSDGDHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHW3</accession>
    <name>A0A232FHW3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000202">
        <property type="protein sequence ID" value="OXU30048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHW3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12359" checksum="2751CB46BF94634E" modified="2017-10-25" version="1" fragment="single">MFLTMAVQHQIYSLYRNVQIYKICKLLLNLHTLISCNSLVTRLTMLSCINVSDQLNTNSILVSFPLNATHTHLNGEKQKSEAGQHEKHLNPDTKQINVNSAQTHTSSPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI03</accession>
    <name>A0A232FI03_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_009262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01000166">
        <property type="protein sequence ID" value="OXU30371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FI03"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="105"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="274"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU30371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="434" mass="49550" checksum="13CE8270DDD3D3A5" modified="2017-10-25" version="1">MGKTAVFVLATLQQLELAENKVLGLVMCHTRQLAFQISQEYERFSKYLPKVKVSVFFGGMPIQKYKEVLKNNCPHIVVGTPGCISALVKGKKLSLQHLKFFILDECDKMLEQLVIFVKSVQRCNSLTQLLTEENFPTIGIHKRMTQEERLTKYQSLKDFQQRILVATNLFDRGLDIERVNIVFNYDMPENSDTYLHRVARARRFGTKGLAITFDCDEADAKXRFRLGHLATARVGGKQSFGLGDVSHLRVGFPNQQGVREIQQILAEIFFGGMPIQKDKEVLKNNCPHTVVGTPGHISALIKGKKLSLQHLKFFILDEDVTDRRNFPTIGIYKGMTQEERFTKYQSFKDFQQRILVAINLFGRGLDIERVNIVFNYDMPENSDTYLHRVARAGRFGTKGLAITFDCDEADAKMLNDVQERFDVNIAALLDEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI50</accession>
    <name>A0A232FI50_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi phosphoprotein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000168">
        <property type="protein sequence ID" value="OXU30365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI50"/>
    <dbReference type="STRING" id="543379.A0A232FI50"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000001">
        <property type="entry name" value="Golgi phosphoprotein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34002" checksum="C2D45CC69672A392" modified="2017-10-25" version="1">MNRADGLVQRRRGTANSGNGTGTHDGSNDGQASHSNPQSPHDSDGSSVKDLNSNPALDEDSDKETRLTLMEEVLLLGLKDKEGYTSFWNDCISSGLRGCILAELGLRGRVELEKAGMRKRGLLSRKLLLKNNAPTGDVLLDEALKHLKETDPPETVQSWIEYLSGETWNPLKLRYQLKNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTDNLAKTRLVRKIQEAVLGRWVNDAGRMDRRTLALIILAHAADVLENAFAPLSDDDYEVAMRRVRTLLDLDFESEAAKPNANPVLWAVFAAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI63</accession>
    <name>A0A232FI63_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000210">
        <property type="protein sequence ID" value="OXU30007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI63"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15200" checksum="F7668BF4A47CA439" modified="2017-10-25" version="1">MDFFELKIVLLTDGFLLFLFFVLSACPSPQGMPRVTKGGWYSGNGQEEQLYSISGLSAERRAPNLASVVGDLPARCIGNFGPRNTPQVYGAVPWAYARDIENLPFNELGKIVSRDLFILLTEVLEIFSFSTKDSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIR8</accession>
    <name>A0A232FIR8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIR8"/>
    <dbReference type="STRING" id="543379.A0A232FIR8"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="595" mass="67619" checksum="689A3F9A87B3B470" modified="2017-10-25" version="1">MTNRDTPLHSAVRSYDSDLGPIKSLLEQDVSDIDVANSEGQTPLHLVLLTFNELVKSSRFPLGYMAYRWSLYDKMDLIELLLDYGADVNAVDANGDTILHLLVVQRDGFVCKKIAELLLKHGAEVNVVNVNGDTPLHTLIGENGRLDTSCNLELAVYLLEHGADVNAVNAKGETLLHLAVRNESFSTEKLIEYLLERGAKDEIVDVNGDTPLHVLYQQDNKLCTCNHLRVFLRKCRNINSTNSKGETPLHLTVRNKKYCQLPLIKLLVDRGADVGREDALGENVYQAYCKVVNEDENRRREPMLDILLRSEERRHVNSSLHVASLFHNVDSVHRLLRRGSDVNATADFGFSPLFYALIEHEYRRDKIVDMRSVVKLLLDYGADVDHRFTHSDLLLDTGMERYGHQYAHEVCSLVELAEYGTNGMCHEDYKAVRYHFFKHVVKLLALVEMGCNEQYDHLLVSRKPREICLRLLGEEEFNVWRSRCFEELNSMSEIEIGESKLTFLELMLASTTKTAIFAKNKLSVEAFHAEKGLFPMYHGMLDAKLAKALERRKLVESAATVLSEALKFADPSDEFFSRTLAYCSNQDLINIINRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIW4</accession>
    <name>A0A232FIW4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acyl-CoA reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000155">
        <property type="protein sequence ID" value="OXU30480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FIW4"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="186" mass="22180" checksum="059FA9DE61A4BE09" modified="2017-10-25" version="1">MDLEKMPRSGQLDELYERLDDDLERKLPRIEDSEIAKFFAGKTLFVTGATGFMGKCLVEKLLRGCPQLRHMXMFVSIFFRATKHMDQIIYFGNGDWRIHCPKTMQVVDRMNYDDKELFNCDIRSLSWAHYVFIIWRGMKRFILKEDLDSKAGRRKYVQLWYMHYGLLMIIFAALCYYAMKLFGFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIW7</accession>
    <name>A0A232FIW7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000162">
        <property type="protein sequence ID" value="OXU30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIW7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10707" checksum="F9A0EB842A96F69F" modified="2017-10-25" version="1" fragment="single">TEQGEKAIKGVLEIQNTIQDTEQERKCIWKKIRDKLDSMNNVVSNESNIYRSVKSDLSAIMIQVKQLEREQVAREKSKKSLGLMLKKAEMSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJB9</accession>
    <name>A0A232FJB9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJB9"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="40729" checksum="32320E639CDAA2C8" modified="2017-10-25" version="1">MESYPIRYLLRHIPPYLSVLRNENGSLSTVSGKTYPIVEILSKHLNFTIKFVEILKSVDLKEVIDSTLTRLRTGKIDMLTTPLPLLFNNSLRDFEIGQIFYTETIVALVPIRFVSYEWPTFVVYNLLIYAGLISSITHFAIFLKFDKIYWNYMNIFRVHVQNNEMPFNTLDDIQKSNLPIYVDDTYFNAFYEINQFVENKQLKFDRVYTEECVEKLIKNRDRICLTGQDFGLTKLNSLNNTSAMKMSEYIFGSMEHKYFYPKTSPYAKKFDSVIQKIIESGIHKSWKEYKKLDGSSKIMKAGNIQNELMRSACVTFITDELQRFKMPALRFNLNFDASTRESPASVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJS4</accession>
    <name>A0A232FJS4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Coiled-coil protein 142 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000115">
        <property type="protein sequence ID" value="OXU30833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJS4"/>
    <dbReference type="STRING" id="543379.A0A232FJS4"/>
    <dbReference type="OrthoDB" id="6579237at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026700">
        <property type="entry name" value="CCDC142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055350">
        <property type="entry name" value="CCDC142_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21436">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21436:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14923">
        <property type="entry name" value="CCDC142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil protein 142 C-terminal" evidence="1">
        <location>
            <begin position="565"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="766" mass="87217" checksum="7C0A7DEEDBD5CF44" modified="2017-10-25" version="1">MTFNQITDKRRIDFSRGVKAPADSQRHTQMDSNYRANVGKWLPRAAANLEKYFADSSALSETMGRLARRIAALLKNASRSDSYDQTELKSLIKELESVIPEYRMMSEVVETQNLIFKYKIEHLTTTLKRGVNIVARCTRLLINEICSCTNHEFLRMIFRLVNVYNDLLSLDHDVSEPSVNIFYNDCPNMLEPLKIISVSRILQIIANKRAEEYCHELIDCLLANYRSSCDKDDSRFMASNDIEVAENSSIEIYRTLTKHLTPPITSVTGAREAVSNIESMQALVNTQNEQVVRLLNVVKIISPQLLGSDATRIENDELKIRRTAVKKVTEFYQEVAWGSVSSILDHVVLWWSREALAARHSHGSQHLKDWLHQFIQGSEEYSEKSNALATKIVSIDYILLPVPSTVRPALQTLCDALGCHVTITAWDQLFRLAYTAAFECQSKAPPEIAEVNALTSQMSSFHLQQSSRECITKGTDTGQKFVELFELLMTLSNACETGGEWVIGAPLVELPLSEQIVVLHRMDHSVHTMRLWAMQEARMIAHTWELEVFFLIVKGDIVNCLDILSYLKEAPALCTKILAQIGRVVSLANLHLCFPKSSYWRRNLSVAPNAPSLYVESYFERVLLPILEVINDPETSNMVLRIMCEAWLDYIYLHKIKFSEWGALQLLKDFAHVLTWVTECGIISEKVRQHLLKNEVLRRCEGVGRLLLRHPGEAISMNKKLPQRTSDNGSPESLGLERMPAEMYVPNQEQWLELRASKGLSFCCMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJZ7</accession>
    <name>A0A232FJZ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000112">
        <property type="protein sequence ID" value="OXU30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJZ7"/>
    <dbReference type="STRING" id="543379.A0A232FJZ7"/>
    <dbReference type="OrthoDB" id="2145765at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028118">
        <property type="entry name" value="Chibby_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14645">
        <property type="entry name" value="Chibby"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="111" mass="12673" checksum="5B213B879B8FD2ED" modified="2017-10-25" version="1">MIKMPHWLNKTSFSPKKTPTRKASVSLSSKDLSPKRIEKELGPNIGEIRICLGDQQAVFDGGLWVPESGKVSGTYKENEKLKKEVKKLEEENNLLKIKFELLLDMVLTFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK02</accession>
    <name>A0A232FK02_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000105">
        <property type="protein sequence ID" value="OXU30913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK02"/>
    <dbReference type="STRING" id="543379.A0A232FK02"/>
    <dbReference type="OrthoDB" id="8440449at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013099239" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU30913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="265" mass="28649" checksum="CD5233CD61562F41" modified="2017-10-25" version="1">MQYLVLSLTSALITFQCGSARRAQSRIVNGAEALPGEFPYQISLNVYGTHDCGGSILNKDYVLTAAHCIGSNDTSIMKIIAGTTNLYELPESATTHNVSEIHVHKEYDGDDGWKNDIAILKVKPPFKFNKYIAPAKLPIKNAAVNPGDEAVVSGFGRIKQGGPLSQKLLKAQVSIETLEYCQREIIGDPVRPTNVCIRNATAETGFCNGDSGGPLTVDETVVGIVSFSPNLGCAGFSRKPQVLTRVSAYIDWIDEQMVKGTKINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKI9</accession>
    <name>A0A232FKI9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000101">
        <property type="protein sequence ID" value="OXU30978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKI9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="9722" checksum="2ECA6C202DC6DDAE" modified="2017-10-25" version="1">MTEKRSLNLLIELTLYSLNAAENSGPLKQRRFPEDYRRDSKHHVPARTPPANRLSGLAVTDRPFSLSALKVTLKIRGVKLLEGVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLV3</accession>
    <name>A0A232FLV3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLUF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000048">
        <property type="protein sequence ID" value="OXU31563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLV3"/>
    <dbReference type="OrthoDB" id="548795at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055308">
        <property type="entry name" value="TEX47-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34035:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24787">
        <property type="entry name" value="TEX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="29244" checksum="F5AEA775ADA37DB6" modified="2017-10-25" version="1">MDEPKRKSFLDILRKNLSLADRLAFITRFVYIGECRGSTSDLQKVRTYEDDKFRENVKEIKAEYGEDALTGILLVYPRNFIHLVEATEEIIYRHLKGVLGKQSEKLIGRVIPLPANHNIFKLYFIDWHVVQIRNPPWLLDKIETIELEEIQRQIKNCLSKMYLLSEYLLNERDASREKTIDALTTISRVKPYYLPEVTIVEYLLSIKTPVLEDLRNYINKFDAVPSINFYNEYLQYIKTTVLSYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM18</accession>
    <name>A0A232FM18_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000037">
        <property type="protein sequence ID" value="OXU31695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM18"/>
    <dbReference type="STRING" id="543379.A0A232FM18"/>
    <dbReference type="OrthoDB" id="6351205at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF17">
        <property type="entry name" value="BEAT VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="249" mass="26809" checksum="D5FE7082F3AC913A" modified="2017-10-25" version="1" fragment="single">MTHIGNGKVVGEKDDKLEPRISFFGRVSRKEGSTFIILINGLASAVSSSNTQDVTLVGVTRNHTGRYSCEVTEDGPTYDTKVQEAYVLVVDVPETEPKIVVDREHLPAGETLRANCTSGASHPAPNITWTLNGAPLNNITMRFKVHTKTLPKAFDDRNSTFSSLNLETAGMFQDGRIRLRCFAEITPVYKASASKEITEEGPYLASITGDASPHSRHTSGSGRADSMSLWPCGLALNVVLGLLVGASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMK9</accession>
    <name>A0A232FMK9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000032">
        <property type="protein sequence ID" value="OXU31760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMK9"/>
    <dbReference type="STRING" id="543379.A0A232FMK9"/>
    <dbReference type="OrthoDB" id="6354602at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF3">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="380"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="496"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU31760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="635" mass="68457" checksum="3446477A906C7A74" modified="2017-10-25" version="1">MARGARWHLCSSGTEWTAGRTYVRSGVSSSSQWGNGENTGGLSVLKRPKSSSSINERIAKKEEKKTYQETKGIERERLSPREMSSASSALGALAVLSIILATTAGLILCFVLIHSVETKPIDLWVDTGAQVVTPNLPKHTNAQRIPSRPDAPQSSASVRNSFARAIIAFPNDALRSRNNTHNKSCTGTDLSPMMSSGTESEVTGYLSSTTGSIVSSTSYRVENVTSSPVTTTTTTTTTTAEYPEIANVATTAASIGTVVTTSPSATSASPAKDPSTTVKATISSTSTTTPGPPLQERLVGSEGLASSSFPRETTRLSETTTSVVQTTTTTTTTHGSSIVMVGKSVAAKSRNDLVGGTFHEIKPAQKVNSAGYFGGKMVKPNVASALGKYTPYFEDGQTELNVTARIGSTVILDCEIGMLGNKTVTWSYHSADVFRLLTVGRNAYSVDQRISLYFRYPTNWRLRIQYATPRDSGLYECQVATYPPLVKKIHLLVTAPILVIMDDSGRIKSGERHLKAGSSLHLRCEARDVPERYNETVIWTRGDEILNEDVSENRTTELMDGREIQVIVSTIVIERATPRHAGNYSCVVPEKARATIAVHVLNGELPAAVHDGNGVSRSVLNLWLIHLTVSYVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMW1</accession>
    <name>A0A232FMW1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA dehydrogenase family member 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_004850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000009">
        <property type="protein sequence ID" value="OXU32076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMW1"/>
    <dbReference type="STRING" id="543379.A0A232FMW1"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF9">
        <property type="entry name" value="COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="100"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="195"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="308"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="13">
        <location>
            <begin position="504"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU32076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="72320" checksum="7BEE3B356FCC4B0A" modified="2017-10-25" version="1">MLILRVVARRHLPCATSACQHTRLLSTAQAREEKEILRDFTLNLPTPQPKKPKRPPFAKNLFLGKFDYEWLTYPEPQHVDRYNEFQEWLEPIERYMKTVNPKEFEETETIPSHVLQKLRELGVLGARIPGDYRGMNLLNSEYMRVLETVGTVPALGLFLLKQGVPPIDIFIKWGTVEQKLKYLPKIATGQSIATVAVTESNSGPSACDFETLATLTDCGEYWYLDGEKTFVSNASISDVFIVIGHAMQSGELEKRPETLSAFIVDRDTPGFTVLKDSIKTVGLKGFETGKIVMRAVKIPKSNIIGEIGDGAEQLLEMFRNSRHFIATQTIALLKNFQRKLTKDILPRKHFDKMLFETESAKIVFANISCSIYAIESVLYLTTAAMDIYDGQDVQLETALVEQFCVQECLKRIQESIWLVGPKACTLVEPFEQILRDAFTVSNYETSLLDTKIYSALLGLQHYGFDMADHIKKNRNPFTFPSYVFQQIFSQQGALKLHIEDYLHPSFRECAEFCDRSLFRLKDSAENLLIRSGTEVGKEHGALQRLSDIASLIYVYVAVIGRASRSYCIGHRDSFNEVKISMIMAYRLQQEVYRLSDDIKNSEYSNGDYLCRELADLHFEKKDYFAAHPLQRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNS8</accession>
    <name>A0A232FNS8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNS8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8330" checksum="0A0F75D702371B35" modified="2017-10-25" version="1">MDVQKEEEKDEGRIANTQAVQTGDDELGRTVPQEQVNPRETDPLDRMEVEATAMVNPATDEPAAWGSKPPPQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNX4</accession>
    <name>A0A232FNX4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000009">
        <property type="protein sequence ID" value="OXU32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNX4"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18495">
        <property type="entry name" value="BACK_GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18305">
        <property type="entry name" value="BTB_POZ_GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU32077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="499" mass="58233" checksum="DE21EC58DC127457" modified="2017-10-25" version="1">MGSYASRLVSASNSAVNSVYQSRKRKRIQEDDFESGSRFIEETLQTPKRRKLMTTAQYIYKTLFEEEKASDITVVMLGKAWRLHKVYISQSPYFASMFSGSWRETNERLVNVEITDPNITLDSLAVVLGSFYQDEVCLEPKNVISILATATLFQLQGLIDECTEIMAETTNIKTVVPYYDAAVSYGVPKVKNTCKKWLEFNLMGYGWLYPSFLKEISPELMAELVSSSDLVVMQTEFCIYMMLRVWLFVHVQDKDEASQHEEFYRNKTWTEPFLETKKGKVFSAPFKSLRKKYLLLNHQDVKILQNDNLMPEDWLYKSYKEQWLHILRIDSNRDTGSLISPVTRFFQKQAFRSRPKSLSEETFARECFRCARCVEIPGEHVWRWTAFHFGLDLIVNLDLTVLRFKRYSRLDSEHITANHNKHHIVVRIRLFSLNEQRQIKHLQDSGLVNLSLQRNQEKQVMSLDKELSFPLHISVNMQVVTPFTPVEELKTVNTVIANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDP5</accession>
    <name>A0A232EDP5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006019">
        <property type="protein sequence ID" value="OXU16486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDP5"/>
    <dbReference type="STRING" id="543379.A0A232EDP5"/>
    <dbReference type="OrthoDB" id="7697185at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="557" mass="63083" checksum="96F6194A7C7D391E" modified="2017-10-25" version="1">MWPIQIRIPNIPESAAEVVGIDRGSGKPSSAKEFFKPSVDELLDIFEDGLEFCGSVKIVYFRCLIADGPARAFVLDHCGHNSTAPCSRCWIRGWCLRAGVMVYEGTVFVSRTEEEYSSRVDILHHKGLECPIGVFPINQMSSTVFDYMHLVYLGVMEKIFQGLIDGKFSKSAKLSSAGVQVLANRLEKVKEYCPDDFARKPVNVLKHGKFKATEHRQIQLYSGPVIFYGLLNSDALYKHFLLLHVAIRILSASEIYGIESLSYNVHSFLHLAGDIRSFGSLDSYSAFSYENNMSYFRKLCRKPNQPLQQIANRRAENCQVNVHKHHDKNSVKFIGAHSLGSKPPFENSNYSQYRKVVQVSYSLSISKPDGTIILRNGAICVIQNIIQLQNECYLLVKRFLTIENFFDLPCCSSTVDVFLCSRLSSDYILVSLEEIDNKCFRMPYWQNQPTLDMQSGYFMSKEQFKEAGVVPANVATARMMQKMMTLQNAANTLHHSEGSKNLYRSMSELTSSPKTPSNIIQTKNIGKSRTKPGILRHTQQKPLIQQPFTQQQQPLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDQ7</accession>
    <name>A0A232EDQ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006042">
        <property type="protein sequence ID" value="OXU16481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDQ7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="11719" checksum="BCFC3E2A63AC7461" modified="2017-10-25" version="1">MKLHDQIEYKQNCATSKKTFENKKSEYVIRFARTINFNTNTSYVWEKIKIIKNSWCKAKANCQKSKEDHDKKCTECLNNFSRHVNKMISLLNPFRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDR2</accession>
    <name>A0A232EDR2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005986">
        <property type="protein sequence ID" value="OXU16499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDR2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="248" mass="29011" checksum="B2226BE984091D54" modified="2017-10-25" version="1">MYGLPRKRYAPVCDWQYVRAVKKAKRENLPFPIPPRVGYRKYVRVCDWQYFQDWQSTRSWRRCDRHIKYGYLEGEYGLEEDTWGLCLLFYYELHDWQYVRAVKKAKRENLPFPIPPRVVPRLAIYPLLEALRPSYQRRLPGSSKIGNLPAPGGVATVISNTVTWKVNMVLRKTPGDFAFYFITNYISKISNLPASGGVATVVSTTVTWKVNMVLRKTPGDFAFYFITNYVFIQILLIESILRCLTQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE18</accession>
    <name>A0A232EE18_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PRANC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005638">
        <property type="protein sequence ID" value="OXU16606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE18"/>
    <dbReference type="STRING" id="543379.A0A232EE18"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU16606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="95897" checksum="ECDE5D3EB417CC0D" modified="2017-10-25" version="1">MGSVMSRLRRPEAFNYNQRYQAVTEYLIRAGCPVYSFEVLNKAGRLSAYLHFAVKFHYIPEAIELIRLGAKPPVKNRKGQTTLQYAVVSKRYVEGVEKIIPNGIHYKKMKFYGLRSLRYATKARKKKRLRELAATQDDINSAHSLLLVKMLLDHGSDVNNKDINACTPLQCAIYTGDLELVKMIISAGADINVQNRIGATPLHDAVLSCNEEMVFLLLRPEAFNYNQRYQAVTEYLIRAGCPVYSFEVLNKAGRLIAYLHFAVKFHYIPESIELIRLGGKPPAKKKRLRELAATQDDINSAHSLLLVKMLLDHGSDVNNKDINACTPLQCAIYTGDLELVKMIISAGADINVQNRIGATPLHDAVLSCNEEMVFLLLSKGANVDAKTLEFRNSPLHWAAMLNIDDSHERCAIYTGDLELVKMIISAGADINVQNRIGATPLHDAVLSCNEEMVFLLLSKGANVDAKTLEFKNSPLHWAAMLNIDDSHERVITRLLQFGSDLHAANLNGWTPFNYIIRCCDVNLVRHCIAQYDEDLSVVAPGDNNALAFAALNPCKNVMDLVLESVVDVNHSSSYGETPLHFACELSMLENVQRLISMGADVKAEDENGVQPLHKCIFLPYTARVSKNLPYILHRANYAEERKRVVRLLLECGSNVNKKIVGVIRGQQDEMSLFRVAINLEEMELLNLIIAHAAKVEAKSNEQLLDDDNLAVIDEEPEIKRYHQMCRAELMTMRTTKIADTLLTFFSVLTEPLEVVARYTRNAEFVRAFEAGDYKISCAIYESMLKEKFDAAFVKQKKFEQVVSVLCAILQLADPTDVMYEIIFKHLSEADVELIFENSKITDMDDEKFAKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEU2</accession>
    <name>A0A232EEU2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005236">
        <property type="protein sequence ID" value="OXU16848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="769" mass="90175" checksum="245459CE7144131D" modified="2017-10-25" version="1">MESSSGSESDNAEDSDWDSDEGDGDTTLKAIEFDIEFDLKSWDKIKPIQKLYRDNRIYDKLKGDWTDIVADKIWRALKLQCCYKFKVHKFYKRKNLPYLYYYGWCTECGAKFTGTCETKPTEHDFLIKFHIKTFETYHIKHKDKRHLSRERREIAKNSLRHMKPKRFKVEEAKKFMDNSDIIPSLLSNSVVYKTARQEIRDQDLKLENYPGNPIESLHEMMDDISAVKMISTYPLIVMYWTEEQIKLWNEANELDEVDISIDASGSFILDKMLKHDLYYGQKLIXNIFTWAIIWPSELIVGYTHNLLNVATSVFNECSLDQYNEYCYQYLVKANTVLPYVLIRTDIYEVLNVMDEWDCLQNQSKKKFMCCVIYLSSLKTLDLFQETVTDIIILCQTRFENAVTEASRMRLIMKIKTSSIKECYEQFLKYSSDEDAKKVFSSALLSEKSETKRSQNAVFNFINGLKLEALKVKSSYETEHNGYCCLNTLLRIFELFLDYPIWTKLIEFFYYDTLSITKNALQHLLYLKEQNVNEKKASDFVVFHWELLKSICLNGRMFVNETKIVKNTLRKANKHTYLSFEENWKDKNVFVIEIKDNDDTINESKEINYDKNELNAEGNSIDDKNVVNAEENLLCDKEFYDQNDSAFHQYQENEQCNILDATPTLESEIPDSASHSTPIQTNRSPASENNNFQIQTEPKISTEFGNDYYNLIAVKSDNKDLLNYSVENAIILSEHSYSCSPLVTNKYFKTIDHDFVLETDDVLQTSISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEX0</accession>
    <name>A0A232EEX0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHOD1 N-terminal GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005184">
        <property type="protein sequence ID" value="OXU16919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEX0"/>
    <dbReference type="STRING" id="543379.A0A232EEX0"/>
    <dbReference type="OrthoDB" id="9806920at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041387">
        <property type="entry name" value="FHOD1_GBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF4">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18382">
        <property type="entry name" value="Formin_GBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHOD1 N-terminal GTPase-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="19599" checksum="B007B2CC5541FF2C" modified="2017-10-25" version="1">MSLTCRVQYLNDVDPFAYASSYPEPPRPPVHTFSATLPLINQLAAVHRLLRAPHRVSTLFFIRILLLSYSVHSLSSFSRCCFFSYSSLCTCFLPSRVSSFLLRLRVCFFAVSTSKSGDSRRMSLPQPWILAAAAARVAFSNCDGKLARARGCMEKFSQSSSHSRTCVNVCVNRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF54</accession>
    <name>A0A232EF54_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005104">
        <property type="protein sequence ID" value="OXU16990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF54"/>
    <dbReference type="STRING" id="543379.A0A232EF54"/>
    <dbReference type="OrthoDB" id="10028922at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="69003" checksum="7C0A18D500066E9D" modified="2017-10-25" version="1">MPYLNILYAQSNAILDALRSGLKKLVRDLKEASSIVYVIRKHFILFNLTEPTRVESRLNQLGLVQEISLNSSINNVDLDVNNARSCTSDGDIPVSISDIENNADLHCEVESFESAGSGSESSNSDYSYRYSSIDSDENSSNASSDSDEIAYDISQRETVSRGDYYHFGLKNAILKIASEIIKCGNNKSDLRLLINTDGAPTGKSSEKTLWPILCSEISQQTVRPIGIFYGDHKPTDANEFLKPFVDEAVEINKKEIECKGKLFNVQIDELVCDTPAKAMVLNISYPTGYNSCTKCDIEGTYTDRGNCSMFRLMGLFAILLRKQDISYPTGYNSCTKCDIEGTYTDRVCFPNEPTASLRSDDKFRNFEYYPEYQHKETILNKIPSFGLVTNSEDYLNYAENLLKYFVKTFEKIYGTNYIAHNVHNVLHLVDDVRRFGHLDRFSAFRFENSIFKLKTMIRKYDKPLQQIAKRVSEHENGTIENTNIAINNSSIQTFKKPHNGGPVTTRQCTDQYRVLFYNNYCIKVSSKKDDCVLINGDYVKVYNFVRYNNIMYVIGKQLQPVDDVYNKPCKSSNLKSHVVKLDDKLKMWKCAKIEAKLMFYRNANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFC9</accession>
    <name>A0A232EFC9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005064">
        <property type="protein sequence ID" value="OXU17047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFC9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="9018" checksum="EBB997608CE8F66A" modified="2017-10-25" version="1">MKSEKDARELTSHKKGREERQKEYTQLLRRTQRNKKPKLSRATSSTSSALISDLAYIPCQVFHFDHVFKVKFQQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFY4</accession>
    <name>A0A232EFY4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004908">
        <property type="protein sequence ID" value="OXU17261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFY4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="180" mass="21732" checksum="A9B90AD5B587CFB2" modified="2017-10-25" version="1">MCCKRINIYKSKHECGINWCNLCREKHDTRQNSAYREHAEIKIYIPNLCCEHEIGREIIHAGRVREFMLLEGFRVDSYLPPENDNAKGIVFEYRGCYTRGCSICFNKQRDKIMSYGRTMDESYENTFQKIKKIKALGYEVREIWECTFDRIKAENREIYEYVTQHPLMSRITLNPRFFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG60</accession>
    <name>A0A232EG60_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004856">
        <property type="protein sequence ID" value="OXU17331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG60"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9843" checksum="1F0BC4E036DD2019" modified="2017-10-25" version="1">MEYFASLRCFDDFIKYYYMPVSSIYFNKNDDHPIKPNDLDDFDKKHKYYVLWSDNIKYQCHIVCLGVVRSTGVNKHLSHNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGJ3</accession>
    <name>A0A232EGJ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004767">
        <property type="protein sequence ID" value="OXU17442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGJ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8793" checksum="72E62E73C795018F" modified="2017-10-25" version="1">MGLKRKNIKESNLKDICLAIIAELQYSEYNFRIASKSPDVNFVWHLDSYDKSDKDTENVLIEYLQICLRREHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHH2</accession>
    <name>A0A232EHH2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004523">
        <property type="protein sequence ID" value="OXU17771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHH2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="274" mass="32144" checksum="5C9EA2EA178704EC" modified="2017-10-25" version="1" fragment="single">TSLIPSPIFSHVPPLNYPCDSTTRPYKTYRQNDLSSFCNLHLLELHQIVGALTSTFSVNSKRTYILAKRKMDSKKRVEEDFHAYRRVILSPHSRLDTLRNTYEFTLSPDKEVAILCGERFHEIPEKSEFMLRLMCVKEDIGQVASIEFSMETILMLKSHMEATCRVLDACDEGLILQNAEVQVYAMADSRGGDFLVHFEDRNRVKISLDINEIKMWMYKYINIIDRFYKVFTRKTIAKRKRLEKAMQSTIEDKLIGLLQPRKRRYVCYAEPFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHK3</accession>
    <name>A0A232EHK3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004470">
        <property type="protein sequence ID" value="OXU17849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHK3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="112" mass="11646" checksum="3B4B12EBFBF1990F" modified="2017-10-25" version="1">MSISSFRNQGKTISMARLFLIIVVVAVFIPFFSNNYADAGFLTGLGNTLSHLPVVGGEVDKLLHELDGTLNKIFSSLFGDGDSSSSSSSIMSPAMTTASPTLSPVEVSAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI73</accession>
    <name>A0A232EI73_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004320">
        <property type="protein sequence ID" value="OXU18053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI73"/>
    <dbReference type="OrthoDB" id="7553093at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393973" evidence="2">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="8665" checksum="F681590169E1DEC4" modified="2017-10-25" version="1">MSKFVLLLCIAFVAVSIVVAQEEPVCKPGGRICSSDTECCTGLICNPWAGRCTKPKTTTPSPVTEASTAAGATGATGATGATGASNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI79</accession>
    <name>A0A232EI79_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004305">
        <property type="protein sequence ID" value="OXU18077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI79"/>
    <dbReference type="STRING" id="543379.A0A232EI79"/>
    <dbReference type="OrthoDB" id="8063677at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592:SF27">
        <property type="entry name" value="OS08G0421700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592">
        <property type="entry name" value="PBF68 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="677" mass="77962" checksum="A81FED4397B415F1" modified="2017-10-25" version="1">MACYLISEARPEHDAPEWKRDPNDKELFTGVQSLNDHSFAHKSNLAYILAEDMILNTEVLNALIERRSIHAEELLETQRFVGEIIVIKYRETYIFGIVLKKHLHNKPLRPDIAGCIKILQSLTAKYGITSFGFIRDLEIITLSDWEQVIEQCNNTFKGKAISIILFKNNLPLPKVEDSQTLAQQLEDFKCICKKLADANDKPSCTSTQFKLLNSLPQKFSIFRKAWECTPQAKRTTELLISRLLREDKRLSETEENQMSLALQIEALGFKRDRSQSMGQQKQAKSKKDIEELKKRAKCEICKEKGHWARECPTKKSDDERSERVFVASAYCISDAATDSDQNAWIADSGANMHMSPKKEFFTTFSSIRECMKIANNKILHAVGRGTIVIRENLDGKVIEGELQDVYFVPELKANLFSIPMINARKYSFHSYESYCEKFSTFRMAWECTPQAERATKLLISRLLREDKRLCETEENQTRLALQIEALGFKRDRNQSMGQQKQSKSKNDIDELKKRTNSIRECVKIANNKILHAVGRSTIVIRENLDGKVIERELQDVYFVPELKINLFSIPTINARKYSFHSYESYCEVRDKDGKLSSRGVEHKGLFRMLFEVQMPKHTSFRCLKQGRLGKTSTAKPVSNQKAKERSTNYHIMEISSSEEDDVSEASDNIVEKLRTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIS4</accession>
    <name>A0A232EIS4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Round spermatid basic protein 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the round spermatid basic protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004177">
        <property type="protein sequence ID" value="OXU18232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EIS4"/>
    <dbReference type="OrthoDB" id="7689364at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026306">
        <property type="entry name" value="RSBN1/Dpy-2/CEP530"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354:SF11">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354">
        <property type="entry name" value="ROUND SPERMATID BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="913"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1302"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1338"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1370" mass="152108" checksum="3882D75332B3DF4F" modified="2017-10-25" version="1">MATDIASGAVSSVRCDVNSGVGGARIGSEKRADEHEDEAEDSPRSRQVRRSLEQPAQLEGTTPIVVATDTAGAFATVAAPLPPAETSSDSFTLRLPSTSAFRSPQQKAGPAVSVAEMSGNDEASDDAAAATTSRLVDAAAAADATRLMIEQDTAAEGDTPCPKPRAAEMTGNSKGCLSPVDSSLSPNNEVRCTKGAVTEKAGNASSKSPQLAESLQSSGQLVLGSPKSPDYPPRVSLGPNSPASAIVTKSTMTYGLPMVSAGNVWKTNAKIIENAYAKKLKVEPSLENNFHQCGIKQEKEDIDTQSESVERLAVDKVKQEPEELKNEPNSSKCKSESKVVSQSKSHSSSSSSRDKHRDQRSERHHCTRCYKRSKIKRNSIGIQCQRDRRSSTSTVLNHRSQSSCKNYKLLDKQSDKSETSVHLQGLKYKDFIHIETYPNGGASVVHMYQDEIDALTSEQLEELAQEYFQVVFGEDENGNAYHVMGIVHNAASYMPDLLDHMADIYPTLTVKNGVLGHKSDIETTTMLQYKEHVCKAYNNGTFRYGPLHQISLVGTVHEEVGGYFPNILQMLEENIFLKKTMPWGPLSAVRMESPQESNDGPILWIRPGEQLVPTADINKSPCKRRRTGINELRNLQYLPRLSEAREYMFEDRTRAHADHVGHGLDRMTTAAVGVLKAIHGGQPCEFNRITKDVIAFHAADFPELVEKLQLDLHEPPISQCVQWLEDAKLNQLRRQSIRYARVSLYDNDIYFLPRNIIHQFRTVSAVSSIAWHVRLQRYYPEDTTSTTVNAGPRRSSHSHAKSKKTLVDTEEDEQKENTDSQRIDRRDNADEEKKAKERAAEYQGNLKKSDQQQKEKRSSTTETITLDKNATEKSQRQRHKEHSDDRKQERRKSSPEKRERDKKHQDRHRSSDKSNSSKNTNTSGSSSHHHSSSSSNHESSKRKHSEKSSPSSSEHRRHSSSSSHHASKTEARSSSSSSQTLEAVPKPQLKELPKSNDESTRASEPPILKQDSIPVKVDTELLSARQTVGKTYATQVVDKALEIAISKTDVQEQCQSLRDGVSSASKEMLEKIRKESLEIAEKLFSEDSAAVEKAYRLLEAETVSAFTSKLDCATENAVKALIETAEDESKEESVVKNEADENTKIATVEEEKRESSPATLTMPSTSIVEKCIESKQEKSTFEKKPSNSHSDDKSNHEKNEKKPSSSSSSSNSSRDDRKHREHKKTEHRDRDRDRNRDRERDKNRDKERDRKRHHNSSSSSRHISSGSSSHRHKSSKSSKDSSSSSTHNRSSHSSSHKSVSSERNNNPSDPLVSGSTSNSGNHKRKSSSSSSVSSNTEPETKKLRTEEISNNVIASTADQIQENNSANTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ91</accession>
    <name>A0A232EJ91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 8">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_015802</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="NNAY01004096">
        <property type="protein sequence ID" value="OXU18371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ91"/>
    <dbReference type="STRING" id="543379.A0A232EJ91"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000114">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="356"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="113"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU18371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="504" mass="56038" checksum="C62A3FDB9A8610B2" modified="2017-10-25" version="1">MPITKICCIGAGYVGGPTCSVIALKCPHIRVTVVDKSYERIAQWNSSKLPIYEPGLDDVVQQRRNKNLFFSTDIAQVRPYIPDVKVCGRALLTRKTFVHKQAIEEAELIFISVNTPTKTFGNGKGRAADLKYVESAARMIADIATGDKIVVEKSTVPVRAAESIMNILRANHKPGVSYQILSNPEFLAEGTAIEDLLNADRVLIGGEESPEGQAAIEQLCQVYEHWIPRKNIITTNTWSSELSKLAANAILAQRISSINSLSAVCEATGADVSEVARAVGLDSRIGPKFMQASVGFGGSCFQKDILNLVYICECLNLPEVAAYWQQVIDMNEYQKSRFSAKVIESLFNTVTDKKISLLGFAFKKNTGDTRESPAIHVAKTLLDEGAKLHIYDPKVEESQILLDLTHPSVTAEPEHVRERISIYKDAYSATKNTHAIVICTEWDEFMELDFKRIYADMMKPAYIFDGRKILDHDKLQKIGFIVQTIGKKLIRSSISRVWGSQTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJH8</accession>
    <name>A0A232EJH8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004008">
        <property type="protein sequence ID" value="OXU18504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJH8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9713" checksum="7F647E2535D339D1" modified="2017-10-25" version="1">MEQLTGTDRRGRAMRNHTRQETSSSFPATSKFRKNNSKAPLHEFGLSDLYFNIEITSQVAVSTSEYDHDLMTRQKDISANLPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL09</accession>
    <name>A0A232EL09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003693">
        <property type="protein sequence ID" value="OXU18998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL09"/>
    <dbReference type="STRING" id="543379.A0A232EL09"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="183"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39295" checksum="17BA448918B06EDE" modified="2017-10-25" version="1">MNQEHASTKARVVEFKYNWSIENFSFFSAEPGVPVMSLPFAIPGTESNWCFKLYPGGISPESDGHVSVFLKLLKPKTPEVVAKFKLYLEKNNNFVGDSLETGVHNFSQEEYGFTKVIKRDVLVQRKSGLLLDDNLVIICEIMLSLGLIDNRFDNQVSISRHANKCRANFVNHMYDIYLKQLFADVTLLVDGKEFLAHKAILAGRSPLFADFFINNPTKTEFELDDIDCDVMEEVLRYLYSGKVLVNNFVMAIKIFEAANVYMFCDYNLERVCEALLIAEIDASNAADLLIFADNSLENLQQAAIKYIIGNCGEVMSTQKYKDFEALLRSAASSEHACFVNWVSRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELZ5</accession>
    <name>A0A232ELZ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01003494">
        <property type="protein sequence ID" value="OXU19332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELZ5"/>
    <dbReference type="STRING" id="543379.A0A232ELZ5"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU19332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="367" mass="40324" checksum="4AB9C7458AA38A70" modified="2017-10-25" version="1">MSKLKSILDFESHALTILPKNARDYYNVGQDEEDTIRWSREIYKKFRILPRMLRNVSNRDISTTVLGEKVSMPVGVSPTGFQKFAHPDGECGNARAAEAAGTIFVLSCYSTTGIEEVAKAAPNANKWLMTSIFKDREATLHMVRKAEKSGFKAILVIVDNPIYGKCKNSALVDCLNKYKAKAAIFEEYLSTKKDVLVKGYSNNVLDYLLDLLDDSLTWDDVAWLKSVTKLPIVLKGILTPEDAVLGVESGASAIFVSNHGGRQLDNTPATLEVLAGIAKAVGDKAEVYVDGGVTRGTDVFKALALGARMVFVGRSMLWGLACDGERGARDVLEILREEVEQTFALTGCSSVKQVTRDMIVHEKDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM71</accession>
    <name>A0A232EM71_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FIP-RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003424">
        <property type="protein sequence ID" value="OXU19431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM71"/>
    <dbReference type="STRING" id="543379.A0A232EM71"/>
    <dbReference type="OrthoDB" id="418358at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FIP-RBD" evidence="10">
        <location>
            <begin position="273"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="56"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU19431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="338" mass="38153" checksum="17CA8D16E1853FDD" modified="2017-10-25" version="1" fragment="single">FEFLGGDPRLQSTSSSAGVGRSAAGPAFKINELGEPLVHQQVQMIQEQMHALVDTQSASEERYARVKQENATLQARILMLEEASKDAEARAEERLETEQRRHREYASRLEREKELQLENSAIKLQAAELECTRSRDEAARLREQLDKLRAEKSRLELALEEAQHDADRAREAEKRTALSLSETNRALKIAEEELALRIDAERRIEEMAQEMENLRARNKNLEESRDELQAAAAALHVGRELLMPSGQDPNDNTINRKNSPSLATELLLTGSTHDQADGVDTGKSGNADICDNFTTLAEAKQALKEQREVNTRLRSYIDNILLNVVENYPQLLEVKQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMA5</accession>
    <name>A0A232EMA5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TECPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003387">
        <property type="protein sequence ID" value="OXU19494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EMA5"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="5">
        <location>
            <begin position="818"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1350" mass="150064" checksum="BFA50B36B7CFA7BC" modified="2017-10-25" version="1">MPSSNLYAINNEGRVFALSTTGTMWREFMYLGLEFKQLSAVPHFMWAIGGDRQVYVHVHGLDIPIRIKEETFENERWLPLEGFSGRLLPTDRYHFSNQDGSVDRSRDKVKLPSMAWQWEGDWHIETTLDGQPLDHDGWTYAVDFPATYTTTKQWKSCVRRRKWVRYRRYSAMNSWCAIAPLHKDATKVRIDNWHYINVQEPFIDVSIGGNQMPGGNPGGLIVWAVTAYGRVMFRVGVSTTSPEGLRWSAIKLPTGDEASQVSVGVTGLVWLTLLNGKALVRTGVTRENPMGDEWVEVEPPRSELRLSQVSVGMDAVWAVTHEGTVWFRKGIKGEMGGICEQLAVGTGWVEMSTKMITVSVASNDQVWAIGHEDRCLYYRSGITRSELTGKKWRPINAPFQLSRASSNASLSSSNRHSICGTPQQQRHQAYGSLQNQRPVSTSEALIREWEDQSRSAPTPTSLKLFQKHNESLENNIQKTSKKGLHQSESTSSGGSTEINEFNENNVANITISNETLNKSGESIVVSGKGMSSTVKVNPGSWSPVHSVGSVVGAEAHPETDGSVFDPDLTGDSGVFGEDESAAAIYWAECEMLWCKVEAGACLVDLNNPPKWITDGNGSSQGEIAEPWRIRILEELKNRIKGLDFDLSLCEKAIEKSSWVKNGEAKCKLKGSSTYEDCVVELEWISSDSGSLDSGTLTILNPDGATTLVQFPISEIVCVVCCSEPGSPRLAIYTPRLTNCKILRLQFGSDTELEDWIAHLTSVSCQINNAYGQPSPKAVWATTALGDVFVYDPVLTEENQYTDGLYTQELDTAGKSLPFESILQNGFGPGSSLRVSVCIHDDADRISLNLVCHSVTINKYKQSVDTNDVAFHFNPRLNESIIVRNTYQNNQWGDEEREGDSPLRSGSNFTLIINCEDRGLPPQNITHLRIKGKLTLCSLLYKSKTVIIEPIAMFWRQIGGHLKKVETCNSGVTWGIGYDNTAWVYTGGWGGLDFSNNGVNTMVDTHNYFVYENQRWNPVTGYTSHGLPTDRYMWSDASGRHKRTRENTKLLSCHWQWVSEWILDFHTPGGVDRDGWQYATDFPSQYHGKKHFTDYVRRRRWFRRCQLTTSGPWKELGNTKLVDVSLHTSDDPDSDSPVHVWAVAANGEALFRRGVSEFCSTGVSWEHIPSDQALVSISIGPKRQVWAVGKNGSSYWRFGISDIKPAGESWQNVEPPSGSHLKQIAVGSNIVWALDTSGKISVRREIQPKVFPEGTYWQTLPSMTNDPIHIGVNTELSVPSSIHVSVLNAKQGFRHVSVGHVPGHVWAISGAGIVCKRIGITEENPAGSGWATGIGANWQHISVGGLANKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMC4</accession>
    <name>A0A232EMC4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003380">
        <property type="protein sequence ID" value="OXU19513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMC4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="271" mass="31648" checksum="423277A51BE4616F" modified="2017-10-25" version="1">MKGDCSILITLLLDKRHLATERRQIAKNSLRHMKPKRFKVEEAKKLMDNSDIIPSLLSNSVVYKTARQEIRDQDLKLENYPGNPIESLHEMMDDISAVKMISTYPLIVMYWTEEQIKLWNEANELDEVDISIDASGSFILDKMLKHDLYYGQKLIICSFNQISDPKFAFFFRILMMKGDCSILITLLLDKRHLATERRQIAKNSLRHMKPKRFKVEEAKKLMDNSDIIPSLLSNSVVYKTARQEIRDQDLKLENYPGNPIKSLHEMMDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232END1</accession>
    <name>A0A232END1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_003433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003191">
        <property type="protein sequence ID" value="OXU19832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232END1"/>
    <dbReference type="SMR" id="A0A232END1"/>
    <dbReference type="STRING" id="543379.A0A232END1"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU19832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="557" mass="59899" checksum="749F2CBB426BA20F" modified="2017-10-25" version="1">MSTVASPLAVGGTRTSGAPVRTQNVMAASAIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILRLLEVEHPAARVLVELAQLQDEEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEACKYIQEHLTVSVEELGKDCLVNVAKTSMSSKIINADSDFFGNMVVDAANAVKISDGKGNVLYPIKAVNVLKAHGKSVRESTIIQGYALNCTVASQLMVKKIVNAKIACLDFSLQKAKMKMGVEVLINDPEKLEGIRQRESDITKERIQKILATGANVILCTGGIDDLCLKYFVDAGAMAVRRCKKVDLKRIAKATGAHFLTSLTNMEGEEAFDANFLGEAAEVATEQICDDELIVIKGPKARTASSIILRGPNDYYCDEMERSIHDALCVVKRVLESKSVVAGGGCVEAALSIYLENFATSLSSREQLAIAEFARSLLVIPKTLAVNAAQDATDLVAKLRAYHNSSQTVVNHAHLKWVGLDLLEGTIRDNKKAGVLEPAISKIKSLKFATEAAITILRIDDMIKLDPEKSKDKSYQDAMQCGELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPF7</accession>
    <name>A0A232EPF7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002976">
        <property type="protein sequence ID" value="OXU20196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPF7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012872925" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="10981" checksum="8F67C2C290C216F5" modified="2017-10-25" version="1">MSAFKLVVLLCLVAATAASGPFGNCQPGPNDLLLDDIPLINVVVGGQRVNRRYPGYKLSCVRCTRGLLNILGELLNIINVGNVGARCRVYGRKLKRGEPLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPH8</accession>
    <name>A0A232EPH8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium channel protein Nach</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_015195</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002936">
        <property type="protein sequence ID" value="OXU20265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPH8"/>
    <dbReference type="STRING" id="543379.A0A232EPH8"/>
    <dbReference type="OrthoDB" id="6436100at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF253">
        <property type="entry name" value="PICKPOCKET 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU20265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="68000" checksum="A7DBF407AB314744" modified="2017-10-25" version="1">MAISTLKKAIPGDNRGRRPDVGAAAADDGGKRGWNELDYQSFFQHRIGRPLQIIVRIAAVVGMVSTIMNLTLEYNESPTLTTIESDSYPARDVDFPGIAVCSSNRMSLSAVNDFAEELFSLETTKIFNVSQSEIRDMLKYLGHLYVFDVDEGEIEEAQFLHAILSRAYGDYSIDSLMMQLTPKCRSILRYCSWEGKDRVCDNMFFLRKTQDGFCCTFNYARRSDGFGSSSTKRSGFVASMVERSTLVNPEYGLSVILNSRIDDYYYKSMPSNGFKILIYSSLDYPDAPSGSLKQVFVPPKSQVFVSMDATSLHSAPEVMEYDVSARNCLFNTEQNKIFKGYYSYSDCIIYCRIRDILRLCKCVPFFYPRLDDFDSPKSCNLDDLPCLKEFTTKWRQIHPRLKKKSNIDESEIKKDPSMYLQCDCFPSCDDVEYKVSSSRIPLTIDKILWDRSIISNRNYSMLHVYFDGPNTIRLKQDVLFYWYELMSDYGGICNLFLGISIINVVEIIYFLLRLICSRRRGTVIDRAEEDSVSVTAVQDADVPAVTIQAKRLNTVKVIDIDEAPPMPLRRLSIEETQLYWQEFVKPINKVSLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPL4</accession>
    <name>A0A232EPL4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002932">
        <property type="protein sequence ID" value="OXU20272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPL4"/>
    <dbReference type="STRING" id="543379.A0A232EPL4"/>
    <dbReference type="OrthoDB" id="10293126at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012036911" evidence="2">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="11124" checksum="DBB7269873AD3361" modified="2017-10-25" version="1">MRARGCVASYALCFLVIQVKLSNSRTSWRLNADKVVKTSPPPAGTAALEDDLILDILTGSTSLGNGQGWSRSAAPPSSTSTADKLQVYCNECKSYVAAAAGGTQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ21</accession>
    <name>A0A232EQ21_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002843">
        <property type="protein sequence ID" value="OXU20453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ21"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10560" checksum="78691BF631ACD97C" modified="2017-10-25" version="1">METKKSIANSDSKLDGCEQKSKNSYWKHLLSQHEKKYAALERRQAALAERVKFMEYALPSLLMGTAINLQQESKNSKSPSKARDNAENVVNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ90</accession>
    <name>A0A232EQ90_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002821">
        <property type="protein sequence ID" value="OXU20492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ90"/>
    <dbReference type="OrthoDB" id="7691871at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="18359" checksum="D1E8BED19496D375" modified="2017-10-25" version="1">MHPDNPYLFGTIGSDTNLNMLNNMQPNYPERLRGTLFRKNISTLCLSLKLTDNRKTDLYQCLGHSATINKNVYAQNSDDEDESNGDQVTYNECTTADVPGNVNVTYGKPSTSGTKAKSALQNEGSEETHTVFNCDVAKTQETNLLCRLLSPESATLLFIKSFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQC1</accession>
    <name>A0A232EQC1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002805">
        <property type="protein sequence ID" value="OXU20538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQC1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="309" mass="35085" checksum="81A527E4F890C1BD" modified="2017-10-25" version="1">MELQEDYDDDEQAGANFSLLLHILRRMQNQITALAASRRSLVTALILISPRQGPYLYRHGAQYQVDWRDKYLSKSTIRCANAATPEKEFEAASGTCRILPPLSLERRTRGKSLLQQTCTHLAQWIMAHGPLHIRTSSTARREDSQLRRTSHRDGQRKFKRTDDDDGDTTGEQWTRSAPIYARGEDFLVKLDRTTTLAFRGRVLPSNGAAHAKGLENPISLLSTGEPFARKKSRTTTNIHEAMISTFHMRKCPRVLKFLESNITIYTPNVMPSIDLPNYYPPLEIANTFVSNKLQSSTLDALSRLSKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQM7</accession>
    <name>A0A232EQM7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002768">
        <property type="protein sequence ID" value="OXU20606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQM7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="204" mass="23630" checksum="6135A21C09E3EA7F" modified="2017-10-25" version="1">MKDDQLLHIKACEIWLKLKDHHQRSTTSSKVHLMTRLFNIKMSRLAVMGLTLILPTLGTRYLGERCRHYIRVHQPRKPPSNEFRLIMFQILTKLQGDDINTVYPGHQLIFGLKLVVISTRVDDTLKVALVLNSMPESYDVLTSSLRCQTKGTSRWRPLREGYRMSIIGERMCVYRTVITRRHCTHHTKGKADKSSAIFVANQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQP0</accession>
    <name>A0A232EQP0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Signal recognition particle 14 kDa protein</fullName>
            <ecNumber evidence="5">4.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Hydroxymethylbilane hydrolyase [cyclizing]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Uroporphyrinogen-III cosynthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Uroporphyrinogen-III synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_003365</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydroxymethylbilane = uroporphyrinogen III + H2O</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01002732">
        <property type="protein sequence ID" value="OXU20675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQP0"/>
    <dbReference type="STRING" id="543379.A0A232EQP0"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006785">
        <property type="term" value="P:heme B biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000003">
        <property type="entry name" value="Signal recognition particle 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000003">
        <property type="entry name" value="uroporphyrinogen-III synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="20">
        <location>
            <begin position="119"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU20675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="531" mass="59108" checksum="D3438D986E66705F" modified="2017-10-25" version="1">MVLLENDAFLVELNKLFEKSRVAGSVSLTIKRFNGHNKPEPREGRAPLPPPTEYLCLVRAMHKSKKLSTVIHSKDVNKFQQAYWNLLKTNINGLKKLKKVKSFYYVPEFQVRQITMKIKHGFDCEILQVLHFEFINLDDLRNTLLDSESYNGLILTSPRAAAAIAMTKMQNPFSLEPWLEKTTFCIGQATEFVAKEQVGLTNIFGSDSGNAKNLANFIVHTMKEKCEKPLLLPCSDIARDTIPQILSNNKIEVKKIVVYKTKAHHFLEEALNEALNQSPHVLVFYSPSIIDNMLNVLSNNKTIFENFKIIAIGPVTEEALENAGIKVDGVAEKPEPTSLTEIISPVLKKLNKMLGRIANLTTLRNLTGLSRSLVKQGNISNVRCYSTKLAAPMYSGQFSCLPKKITLKNAFCPTLSQLTKITANSLIQTRSQSTHGDHVNLWKLERIVSAAFVPLLPLCLMFDNPVLDGGLEAIIVDYARPIVVGPIVPKICFVALYLVSALTLAGLLVLVYNGPGISKVIKQGWAIGKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERI3</accession>
    <name>A0A232ERI3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">dTCF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_003156</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Binds to the beta-catenin homolog arm or to gro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002591">
        <property type="protein sequence ID" value="OXU20975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERI3"/>
    <dbReference type="STRING" id="543379.A0A232ERI3"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007476">
        <property type="term" value="P:imaginal disc-derived wing morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007500">
        <property type="term" value="P:mesodermal cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072091">
        <property type="term" value="P:regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007367">
        <property type="term" value="P:segment polarity determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035277">
        <property type="term" value="P:spiracle morphogenesis, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013558">
        <property type="entry name" value="CTNNB1-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08347">
        <property type="entry name" value="CTNNB1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0709">Segmentation polarity protein</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="411"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="13">
        <location>
            <begin position="411"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="13">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="350"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="467"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU20975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="645" mass="72674" checksum="1B39EB5CAEF1377F" modified="2017-10-25" version="1" fragment="single">MPHVSSSGGGEDLGSEDEVKVFKDEGEDEKRSSENLTEEKSSLIDLTESEEKVSLAGGSYSTGKASARSDLSPVFGKVDPTPHTSSFNMGYLVSPYPYPNGAGGPIPVSMASKMGLTGTHPSGLPSHEGADVPVRHGPVSLPHAQSGNDASRRFLAHAEHVPDLPGERRIPKSLPHESAHQQFEFAQAMEPECLEPLNLVIKKDSNSPAAEPELPEKSSTPVDSKDCIKTSEEDKFQSKIQDNMTILQEAVKSGEAGAPATDQKFLTALYMSSLMQMSNASALRNVSPTPYNVQQNFMQLLAMVEARHRMWQQLSWSVPPNFLRNPVGLPQPYYDGALTNLNEQLCNSPNSLMSYPSLPTTKNDPTSPETKQTFFKRSTIEQKNSSSLPADNTKNQDTGQQNNPDKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQQRYYEAARHERQLHQQRYPGWSARDNYGYGSKKKKRKKERSADPAGVNVSNPFLKEWHALGRDEQAKYYEMARRERQLHMQLYPDWSSRANTNRTKKRKRKQDTNSDPGGNNMKKCRARFGLDQQSQWCKPCRYVHQFAPTAVKDIESRDSFDTSCRKLVSLKAAKRNVWHEPESARWQMFRFQASDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES34</accession>
    <name>A0A232ES34_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002510">
        <property type="protein sequence ID" value="OXU21164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES34"/>
    <dbReference type="STRING" id="543379.A0A232ES34"/>
    <dbReference type="OrthoDB" id="7554908at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14667" checksum="9870B3AF03F246C4" modified="2017-10-25" version="1">MESDLVKITNLKNIENWGIWKFQMRVMLTSHEAFDVVNGTLSKPTPPDDDASQAVKTKNNTDLKEFTKKDGIAQKYIVTTMERQPMTHILSCETAKAMWDKLFAIYENKTDISVHVLQQKWFSSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET85</accession>
    <name>A0A232ET85_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002322">
        <property type="protein sequence ID" value="OXU21552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7689910at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="900"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1996" mass="226704" checksum="55EA438F69553324" modified="2017-10-25" version="1">MSQSSISSCKSSLESRKRARTSSPETPARKSQRKRFILSLPKKYLEISSQSSSESFNKCDTQSTTSLSITAGAPSEAPTETSSSTLEYASLATQYGLSIDCVKQHYSILTSTAQVLVIKTALIKQEIVSPEKALQTSPVFRSKKRGRKPKIKIEPKSEEKLDSPREGILSKRASRNIHNYFESFSSTLGIKQEPKSDDSLEEFEEKKILQNRSQPSKHQDFMQNGSLSRLRSKSSSQLSQLSSSTSQRFSQSHSCSQQSIQSRSSSLRSSNRRLNPLNSRVSKKLTPVEKWTELIDSSGDEFADLRPKKKALNKTAIQTTQEKIETLVSNPFSKIKKQNSQKSKTKSNSFWRKKFGSDDDPATRKRKFLKSFKLKKGDKSDHVNKDLLDSVSKVEVEKEDSEEERKADKTLTCNRMIKKKRISEKNNTTIKNDSNNIELSTQSSVDSLSVNCQYFNSKTVETVTAMPSQSYPYSPVLSFGADPSDYEPDNETRTNEKICDSNDKLSQDYVNSAVDHDNSNCDNNLEEEENNLNDSFLSLDLMESSTKSIDVELSVKPLKEQKGSIQEKNTHTVKKPRAKPKIISDSKLLKNTIIISDPKKIGIRKQLRANSKAISPNSNEQSLSVTSPLKVLNGTDKQTNDVPPSGSKPKFNGITKNLPLDHVTQQQKQQQQNQQSNSLRNNVGVEESFDSLCEDITELTNYDGQAETITLYKGNNQDDADVEVLSLSAGNSPNSEHFKTPTCTFLNSDTKEKSSSSSIISKTRKSPINFQRDSRLSLSSPTVIKTRRNTTPNDTKKKSLLDPNTATNKKSPITFQRSSRLSLLSSKSGFSNVNGSREDESSNGTNDKSSPSASNSTSRKSPITFKPTSRLSLSLKSSVITKAQECITSDKLNNRLQQQNLSSSVNSLSKTQQQQPTASESTSSFQTSSTFVNKDPRLNRSISPIKSTNVVSRDPRLNRLISPTKLPALTDPRFVRSNSRPSSPTTSVVSTYESPDPRLQKRAERENTETIIQQRQEINLVKQENHSSITIRDSQSAQKKASVFERLGRKSPSPNKHIDVKKELMDIVKSGKVRSIGYYDSDDEECISIHPGDMFSSDEESNASPPHRKFTSERMRQNEEIRNKPMSIKDRLTLNNSRINQRNPSSFVTPAVPTTTATTTRTTRLINRITFDINADNQSQVSTVSATTMQPFMQTVPKVSGMAAYASQCRKEPFNTYSNNDAAFNTNFYKDNSAALNDKFYKMNAAQMRKDVDNLSQFGSSPTITFDNNTQQTHDTDSMFTADTVKILFFKRFCFRMLRYGNCSMEMTSCHYSHHVYSLQKLIKEKKLEVLMPILDCAIHQKFNFFLQNVWSSLLPKLNDEMFNVYNKLYQAELRSERFLNELLDYCLNSKLYTVESFVKKLAMFVEKGNRDWVRNICVAIKPKISDGFCWETIKCLAQKAVPPVDMIELTILQCLKRKKNSSHINEVYNLIKNKITNLERSRMSQTMLKQFYTLVQKTCLVNEKEVLNTIPLASSSNDVTEIAVSSPAISRCQSVESLKSAEVENQGLTVNTSCNVQQPINSPVDVLKNTPSRGESTNFSEYTVNEVDSGEPTSVFRDRFWKIYLRASVIDKCLAHEDYDDVWNTLNEFCKENVQDTLLKRAYYHILCKNVKTCQRHISEIIKRAVRNRWPSSQKCIDLLFDVGIYALIDLGNNDLWVMALDLLSSLKIIEPNEPRTTFVLICTEIYLANSDPLEALYLLQRTRLIKTNRDEWLTKDHTKDDEKHRNKVVIILLKALSYNEPEKAVYLFKELLTDQYIYYYPIDLRLYLDKLMLLLLLNGKDELVADMCRLIIGNDLTLQKSTYRELITRMLPIDEVLTNQVLDYAIHLGYYNDIQIKNGFTTVIIDTNSSEEELYLILRRLIYILKLNVGPVIHRLRPNQLKVTLIFEDIPVEKRLYINEVAAKRSDTYISIRNLVNKMLATRFTPPIRISRGKVSKICKLMSRTLVDYLKHWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETF8</accession>
    <name>A0A232ETF8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002276">
        <property type="protein sequence ID" value="OXU21650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETF8"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="17267" checksum="6289014417777D44" modified="2017-10-25" version="1">MENLTDHNDEDSLELASKTWNRVIDSASKTGFREGIKDGSMSVFQDGFDRGYKQAFRVTFLLGVYKGLANSMMKDVQLPLQIENILSKSKKGLCYLCEIESKGSTVAPDQSIDDIDNCQKDHPDKILQILKDYFDPLFQEQNIDLSLLDLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETU9</accession>
    <name>A0A232ETU9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002250">
        <property type="protein sequence ID" value="OXU21726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETU9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7670" checksum="C18310B788716A38" modified="2017-10-25" version="1" fragment="single">EHSSSSRYIDCERSTPQLLQTQPTCHEEAPLERVRCCYCSEWLVCRLPVSLALLIRGRTRDSRVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUG1</accession>
    <name>A0A232EUG1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002142">
        <property type="protein sequence ID" value="OXU21946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUG1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="177" mass="20582" checksum="2ECFA1011B8FC6A0" modified="2017-10-25" version="1">MKQKLPRKIEKNQKEKRRKTNIVTATLPEVPGAQGGQYHVVSWSFGFLRTLNMNIATTTPPKVPGAQGGQYRCHLQEFHGKLTTFLLRLFTRELLRLQNTNIVTSTLLEETMLILFTLDTRYLESHYRHFTRIQRLRKPPINESLIFCETLGDDVDTAHLRHQETTLILSTLGTRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVU7</accession>
    <name>A0A232EVU7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001949">
        <property type="protein sequence ID" value="OXU22480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVU7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9657" checksum="830D48D050E151C2" modified="2017-10-25" version="1">MYISISSHDLKVTKAVDIAFTGHLVFLFSHIINIHIYNTFTYTYIQRKIKGNFAQIAQPDSHFEKYFFSFACFTVIYTCLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWP0</accession>
    <name>A0A232EWP0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_000392</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001834">
        <property type="protein sequence ID" value="OXU22763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWP0"/>
    <dbReference type="SMR" id="A0A232EWP0"/>
    <dbReference type="STRING" id="543379.A0A232EWP0"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000010">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU22763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="9123" checksum="0F6EFDE7C3BC8B86" modified="2017-10-25" version="1">MSRKEALSQFIQQIHGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKDKYGDAFIRGNNVLYISTQKRRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXX0</accession>
    <name>A0A232EXX0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001707">
        <property type="protein sequence ID" value="OXU23167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXX0"/>
    <dbReference type="STRING" id="543379.A0A232EXX0"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000009">
        <property type="entry name" value="Translation initiation factor eIF2B subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="352" mass="39058" checksum="13918F2D5FE16FF6" modified="2017-10-25" version="1">MILSEDKVHESVLKLARSINYGDIKGTYEIVIATIAVLKEIVTNTEWTTAKKLMDSIVLNGKHLIESAPIEACIGNMIRRVLQIIREEFSLELKNKTDETDPQESLHKILTSEGDKDIDFNRTVPSLKSALIEHISEFEAELETCGGNITQQASEHIHSNEIVMTIGRSRLVEQFFKKAAETRAFEVIVAEGAPFLDGHEMAANLAKAHIKTTLISDAAIFAMMSRVNKVIIGTHTVMANGGLRAITGSHTVAQAAKHYSVPVMVLLPMYKLSPLYLCSYEQHAFNKHVSPLQGVISGNNTAIMEKSQSHNPVFDYVPPDLVTLFISNTGGNAPSYIYRLISEHYHPDDYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYP8</accession>
    <name>A0A232EYP8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001592">
        <property type="protein sequence ID" value="OXU23491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYP8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="13074" checksum="59B10D8551D201E6" modified="2017-10-25" version="1">MSNSSSSKSSSVSEIDPKVLSKLLHKLINKTSRKKADRISRMNSSASGTSTSDKVSTKHTSSTNEKGGPPRSLALRLLTYCTTLRHDIPYTGKPALLQKDSMVPASSALIFSHVGKNFSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZG1</accession>
    <name>A0A232EZG1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001519">
        <property type="protein sequence ID" value="OXU23709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZG1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353281" description="Peptidase M13 N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="75"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU23709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="614" mass="72131" checksum="96BF97212E99A24B" modified="2017-10-25" version="1">MHYGFLVFLLTYAVHTAADIETNEISTGCSSDYDCKYLYDHIVNHVDPSKDVCKDVYSFTCQVKNELGIFSENFMKAQYKKLIERVEYSINDDSYMAKFKPIEKERELYKLCMNYGDEQAKHFRTQEKLRFLKEMYNNASHGFIWGIVDQKLYNEGFGHAFFNIRVIPNPRNVDQNIIMLEPPTFDSYAEIHEALKLIEEFSTKYDKFNKSDIEELLHRYVTSDKLKNIQKLVQSVTEAIFNSTTDFTDNGSKVTTIGAWYNDFIKIYERSSVARIDWFRYLATTFNEVEVDNIDYKTPILVKNKMYFSKLFDIFFETSNEVIATSIVVKAIAENIKYIDWNLATNLKLVSDKYRSEFCLHNTKLYGFSYGILKEYKKQPNSDLHQLTNKIIRTFISEIEESIALSYSNETYLKSELDTITAYVHKPDVYFARMVEQFYKGNNIHNDFDPYREIIYGRYGVQIASVLYALLNENKLEDYSLRRYNHNTLKSHLSAHPNYSLDKMRCVIPGVHKDNKKQFIEAMSNVYGLQIAHTALRPSKNDLPLFPKLGLYHIRQFFHLEYIKAHCYMEKDTINSIVLHDEPFYTAFRKCKNSIVKCPKSAAFDRLSKNVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1I1</accession>
    <name>A0A232F1I1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_010295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001314">
        <property type="protein sequence ID" value="OXU24389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1I1"/>
    <dbReference type="STRING" id="543379.A0A232F1I1"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11725">
        <property type="entry name" value="ADDz_Dnmt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040552">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049554">
        <property type="entry name" value="DNMT3_ADD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF25">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17980">
        <property type="entry name" value="ADD_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21255">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="12">
        <location>
            <begin position="522"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="683"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1106" mass="128607" checksum="58392D007DA756B4" modified="2017-10-25" version="1">MLLCRDHEYFLGVFLDFNFMITAYVNIHQKINHASYWSSSLWREMMAMDLFDDHNYCKLNKSNVKIDKAENYDNFNISQENILSYKINNNELMEFDVQNCVEIQCNDEMQNDISEDVINFNSINTNTESRYFNNDATRLNCNEIAKDVNFINTLECMNFNNISNVINSSIATENEHAMNDSMANSGSQCLINNLPPNNHNSTFTSYSTEDSGIESMDSLLFTESEDSFLLNSRDDHCYSFSKERDGAKKSYFNKRKAENSSAASILTNIENSDVIKDKSEVPVKRNRTTKRSREVIISEESPIIEGKYEESRRVTRLLVKNSDEKPVKYIDNTPGKLVWGYFRSGWWPALIIRAEDAGMIPSSEKIWVSWIGESRISELNAKCVDKFSNDLERRIDNLATNPKTKVTCKKQKDEACFKTIQLLKKHFTGGALVKPYIAWIKNNILPYKNKLDELLFYPYPEILSDKLNNLKIVNSEKNEKYLRQQEKERLSKALEPKNLIKKIEKLEKPIEKGGINIVDQKYGMIVWAKMQGYSWWPCVIMDYQHLNRKQPHVAHQWVMWYGDYKYSQVQYRQILTFPTGMDRMESKITATKDELFCKAVLQAAKDYCDKLGYLTEPWKIKDVIHLFYKSKDIYKLKNAELTEPNEEDLYSQTIKKQLRKQINNQPISEGRKKKILECKNLNLLLSGKLPLESLCISCLESGEELEDHPFFHASMCEKCLEDFSPKIFAYGNDAKCFYCTLCGGDDLVAVCDSMSCPRVFCTACIKYIICPEFYEDILLKHPWYCFLCDPSSISTNNVVIKIRNDWRYKMISLYRINCDEEAPSNLERLDRNRKIRVLSLFDGIGTGLVVLKHLNVNIECYYASEIDPDSMQVSFFNHGDEIIQLGDVRNIDEKKIKEIAPIDLLIGGSPCNELSLANPKRRGLDDPEGTGILFYDYVRIMKLVKKHNKKRHLFWLFENVASMPKKFRNQISKNLGREPKFLDSADFSAQHRPRLYWGNLPWGPYQVNNVVLQDVLRKRCNRQALVKKIMTVTTRTNSLNQTKENLKPVLMDGKKDMLWVTELEKIFGFPMHYTDANLQKTRRLQLIGKAWSVQTLTAILRPVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1Q9</accession>
    <name>A0A232F1Q9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001235">
        <property type="protein sequence ID" value="OXU24655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1Q9"/>
    <dbReference type="STRING" id="543379.A0A232F1Q9"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="81" mass="9834" checksum="5E5031D34B324432" modified="2017-10-25" version="1">MPEYVKGVEVKTVPFDPRFPNQNQTRHCYQSYLDFHRCSKVRGENYEACQYFKKCYETMCPQDWVEKWDEQVAENRFPGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1V5</accession>
    <name>A0A232F1V5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase MSL2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Male-specific lethal-2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_010600</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 19">Belongs to the MSL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001282">
        <property type="protein sequence ID" value="OXU24500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1V5"/>
    <dbReference type="STRING" id="543379.A0A232F1V5"/>
    <dbReference type="OrthoDB" id="10012174at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13122">
        <property type="entry name" value="MSL2_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16522">
        <property type="entry name" value="RING-HC_MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000174">
        <property type="entry name" value="E3 ubiquitin-protein ligase MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037922">
        <property type="entry name" value="MSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032049">
        <property type="entry name" value="Msl2-CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032043">
        <property type="entry name" value="Msl2_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048">
        <property type="entry name" value="MSL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16682">
        <property type="entry name" value="MSL2-CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16685">
        <property type="entry name" value="zf-RING_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52051">
        <property type="entry name" value="CXC_MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 19" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CXC MSL2-type" evidence="22">
        <location>
            <begin position="305"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU24500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="446" mass="48011" checksum="3C0F2CBAFAF67EF8" modified="2017-10-25" version="1">MNATSLYVSTCRLILQADSEDPNSWTDLYRLVPYLRQSLSCTVCSNLLIEPHTPTETNCQHHVCRACRGGRKKLKPSCGWCKDYDKYVENVQLRILLQCYKKLCEYLTSTGIYRGLVLAVSSNNTTNGMPCLGASCLTELIKEGAGFKDEFKSNAGLSRSAYSILPCVYTTSTTSTQTGSSNPANVAATSATSTPTIAAAASTAADPLAPQDNPPAAIKTVSNGSSIYSVMYAGSGNKITIKRKAATSTADDLEAVVQPELDLQQSQQQVGVVKCIPASQLTYNQCQPKKPSKSSKKPRSSSTRSKRKGCRCGNATAIPGKLTCCGQRCPCYVESKPCLECRCRGCRNPHTRDGYKIRPHIPELHNLQLQLSSPLDCDGLAADPLGSVQQCLSVSPPTIQVLNVYSTPRLEIDSVSQNLPAALLVGEDAMASTESEAEDSDIQIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F265</accession>
    <name>A0A232F265_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tripeptidyl-peptidase 2</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tripeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_010597</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001282">
        <property type="protein sequence ID" value="OXU24497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F265"/>
    <dbReference type="STRING" id="543379.A0A232F265"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04857">
        <property type="entry name" value="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000003">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3170:FF:000003">
        <property type="entry name" value="tripeptidyl-peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034051">
        <property type="entry name" value="TPP_II_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022232">
        <property type="entry name" value="TPPII_C_art"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12583">
        <property type="entry name" value="TPPII_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="35"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="16">
        <location>
            <begin position="526"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="17">
        <location>
            <begin position="663"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="14">
        <location>
            <begin position="786"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II C-terminal" evidence="15">
        <location>
            <begin position="1022"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="153"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU24497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1268" mass="141454" checksum="6978D9EE35066A64" modified="2017-10-25" version="1">MAENNLDLNFPIWGLLPKKETGVTQFLAKYPQYDGRGTIIAIFDSGVDPGAPGLQVTSDGKTKIIERFDCSGLGDVDTSKVVKTIDGYLTGITGRRLKIPGSWNNPSGEFHLGVKNAYSLYPNKLRERIEQSRKKKLWDEGHKTALVEATRLLQEFEAKHPQLTTSQEKLEKEELEARVDYLNNLEKKYEDVGPTYDCVVFHDGQIWRACIDTSEQGDLESGVLLGEYSHTKEFAPLTQEDQLNVSINVHDDGNTLEIVSLCSQHGTHVASIAAGHFPDNPELNGVAPGAQIISLTIGDARINTMETGSAIIRAMIKVMTYKDRVHTINMSYGERAHWANAGRIGDLMNEVIDKYGVTWVSSAGNMGPALCTINTPPDLNSNSIIGVGAYVSPDMMMAEYSLREKMPGMPFTWSSRGPMADGGYGVTVCAPGGAITSVPNFTLRKCQLLNGTSMASPHVTGAVAVLISGLIAKNLKFSPYSIKRALENSAHFIDTLDPFAQGSGLLQVERAFENLVNNANAPERDVRFTINCGTNNAKGIHLRAGVIDRPRDYAITVEPAFLDSENVDPARKIDFNIRLTMLCDAPWVQCPTHFDLMHMPRAFAIRVDGTSLSEGAYFTSIRAYDVTNIDKGPIFRIPITVIQPSTIPKSAPLPDLTFTNVPFRPNTIRRHFIVVPDDASWAVLRLKTTEKDKTGRFVMHTMQIKPRLSTKTLEVNKMLNITSQSETIQGFAVQGGLILEVAIAKYWANLGDILIDYTIEFHGVRLINGNLTMQSGDGIHRLELRSSLRSEEVVPSITLKHTVQVARPTESKISPLRARDVIPPARQIFELQLTYTFHIGKTTELTPNAALLSDLLYENEYESQMWMIYNVNKQLIYCGDAYPSKYTLSKIEKGDYTLKMQVRHEKRELLEKLTEMPILLTQKISSQITLDVYVSQSQAIIGGKKMVAASVPPGHILPLYIAPLTNESKISKGASLGSYLQGTITFCKDEIGKKVDVHPFKYVLSEPAKKPASQQNNKNDNNNKDKTTKWDEYNEAMRDLQCTWLAKLEPGEHAKELYSDLKITFPDCLAIHIAMLTSLDSTDNPRYVPHDDITEAVINFSGQIVTIADEIIKAIDQEKLLAYYGLKNDQRPDAAKIKSATDKQKNCLIEALVKKGCAMARLYIHGKRKNDAEESQALLDNVNNLWRDAQKFAEATDSKVIVLSLWHAHINKHYGRYMKLLTKYYEDKPVKEVDEKLIDVAKTLGWDYLAQHITTSIPFKYPPAHILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2K0</accession>
    <name>A0A232F2K0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001214">
        <property type="protein sequence ID" value="OXU24708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2K0"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16989">
        <property type="entry name" value="ENTH_EpsinR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="3">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1441"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1474"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1530" mass="172433" checksum="0EFEC29F2E32B732" modified="2017-10-25" version="1">MSISKKGKVVVSIFQMTNVVMNYTDTEAKVREATNDDAWGPTGAMMQELAQATFTYEQFPEVMSMLWKRMLQENKRNWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYSFIDEFGKDQGINIRHKVRELIDFIQDDDKLREERKKAKKNKDKYIGMSSEAMGMRLGGGGGGGDRWMDNPKWASNKSSGGGGDGYNDWDRGDNRSRGFEDANNSDDGEREDSDNETHTSPRKNPGTGERREYRDTMESVDRVPKPVTNPATNTTSPVRAPRTIKKVDLGAAANYGKDQPNLMTSPVKQPPQRSRNEILNDIFDSQNDNNGTVTKTDNDDDDFNPRADNYAPLPTSQNVSSGDFGDFTSAFGSPPTSKPQESGGDEFADFTSAFDSGLSISQQPPQSQQPQISLLGATIPNIGNPMADNLMAPLGTQVDTGFGAGNDLFNTMQSRTLVNQPQTINNSNNNTTMSNTDLLSDLAGFNAPLAPTNNINNANLFNSDTSPFNNTASSGNIKERHTYEKLANQHLLETLQTVSSSKSQNSLKQLRGRILEYSKFLPGPLTPQRFIGLDISYELDVILYSRVLESLVHIFDPNWPLIEGQLDQSVRDVFIVDGANCQILNESLLILTQELKVTEDFSVIKCFAVFLEELIKSDAILSAMVISSRATGVSDFERSTEHEIWQSIIQIVISLPNRVANRMQRNLLDTFKLKNFTSIISFHVTRAIYFLNEATYQNKTEVDTKIISMLLSKMFLLLSRDDLQPLVDIIVEWCISKVNNIQLLIHKILLEIDSHGIENLAIMFMKHLKFTPDILGNLVINENWRHALITRIPLMSWYNDDRILKNFVSYLFYTQTSDDRILINLVINLLDVWGDQSALNHTTFDQHLYITKLIILSVKCMKGQIIPSERDQILKLVFSGIPTHLGSTDVAIRGIGMITGETLTSLLIHDSEVEKLKFEYDGMGKNLLILIETLKNLKIESTEEKMEESKVLTLGEIEFENIGNKKLFELGVECKILKNISITVSQEFVRNPDVNQSIISHKSTNTTSQILPAQLEEELDSDDDLVPYDLSNDIKSSEKLKPLYLRDIRDNLVHTESKDPEKSAEIFEETLKVSEELILMQLQNDDPSFACELLEIFLSLQERSSVENFEVLVFKACIAIVTVHPKQTAEYICKQFHSELSKYSVQDRLLMLNVLCEAANRLSAVEISKADIATKEVAIPAKKKKLSKPVSLFIETDKSRKYETLYDDDFDDSIEEASLGVDWHEVVQRRISTKTRHFAHSTKLPSTTVNKFGNVVDSFFYPLIHGFGNARHSFMYELPRSYHDQECILLTRFLETLASIMTNAQNCTAAPRMAKEILELAWVLRYHDNAKVRLAVVKCVAAVLVSVPEFELKGDLLSALMEIRMWLIDLTQNTFKGDPDRDCKELGRHVLYLVDSVVQGMIKSSTSTKNHQTNNQSQQSQQVGSTWKGAGLNIDLDNIMGSKSNKSGPAPTMNQLASNSPQHQVRPPIGMPTMGYTSPLPQQQPNATFFPAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3E3</accession>
    <name>A0A232F3E3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alpha-L-fucoside fucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_007055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001067">
        <property type="protein sequence ID" value="OXU25261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3E3"/>
    <dbReference type="STRING" id="543379.A0A232F3E3"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="12">
        <location>
            <begin position="385"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU25261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="474" mass="55598" checksum="BCF27372E97548BB" modified="2017-10-25" version="1">MIYKCKSAYKTSVSVIKLLLKMILREFLFVLCFSVLCCAGDKKYEPNWDSLDSRLLPQWFDEAKFGIFIHWGVFSVPSFKSEWFWQYQKVKLPEVDNFMRKNYKPGFSYQEFAKDFTATFYDPKRWSEIFEKSGAKYIVLTSKHHEGYTLWPSKYSFSWNAMDVGPHRDLVGELADAIRKNTNLKFGLYHSLFEFFNPLWLNDDNNNFTTKEFVHKKTMPELRELIENYKPEVLWSDGEAHATEEYWESREFLAWLYNDSPVKDTVVTNDRWGKDTHCKHGDFYSCADRYNPGTLQLHKWENAMTIDRKSWGYRRNAKLSDYFSLKDLVKELVTTVSCGGNLLMNVGPTKDGIIAPIYEERLLGMGEWLKTNGEAIYYTRPWKVQNDTISGDVWYTVGKNGDLYASMLNWPEGDVLKLGAVRAIANTQIRILGSDRMIDWEQSTNHLAIKLPQSAHRGQPAWVLWIKNYEQSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4B8</accession>
    <name>A0A232F4B8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_016293</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001055">
        <property type="protein sequence ID" value="OXU25318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4B8"/>
    <dbReference type="STRING" id="543379.A0A232F4B8"/>
    <dbReference type="OrthoDB" id="7491548at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000013">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000087">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF27">
        <property type="entry name" value="ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="541"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="765"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="793"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
            <begin position="543"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="310"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="499"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU25318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="92565" checksum="892213A2821AE48F" modified="2017-10-25" version="1" fragment="single">YLSLTLDYLFWSAGCSEDEAGADAEVGGCADNAVVSNGMKHHQQRLQPLEGVSEESNSQNTNSNDINGPGNKSERCPQCGIVCRNSRILQLHLEDQHKPLNPAYAIDKHDLQAQFSHQVSCKVCSKTFANVYRLQRHMISHDESAVLRKFKCPHCEKAFKFKHHLKEHLRIHSGEKPFQCSNCSKRFSHSGSYSSHMTSKKCLVVNLKKSRQSSIGATANADRTVAGKKSQSQPQQQQHQPTLQVRREAELLAANNNTLLPILPKLSPSDYRDIQRDAAGPYDMPTLLPQMVNFGSYFLQSSLGKILSQLHAQQQEQQQHHHHHQPQQHPHHNSHHQNSRHRLDESGSEHYDALSQQSEAALSPSTTAPDSEGTTTEGTEGGKESPAPPPPALHHLPHPEQSQGLDAVRRLLETVNTSVTKQLLEANVKKLASSIAMVIKRDIDDDYPDQDSEMSTEVPHYQDDWSATEQCDSQSEGLAAKLEEVHHKAVPAAVPIVPQRQSLKRKAENGLSTHTSEADSEDDEEQMMQQNQQDSQSNGAARRVRARSLIDDEQLAVLRGYYAINPRPKKEEITMIANYIKFPTRVVQVWFQNSRARDRREAKIPALVPLSSLNNHVFNDQPLDLSKKDVLRTISTAKDCSDASSRHTASPCGPKEDALVPKVLANNNIEPEDADESPLVIDEETTDSAEVKQPPASMPVEVIIKAQSPIMQTKNDAEARVNADPAPQTETEQEGLYFCNQCDKTFSKHSSLSRHKYEHSGQRPYKCQECPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4G6</accession>
    <name>A0A232F4G6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000972">
        <property type="protein sequence ID" value="OXU25661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4G6"/>
    <dbReference type="STRING" id="543379.A0A232F4G6"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043489">
        <property type="term" value="P:RNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05686">
        <property type="entry name" value="S1_pNO40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047913">
        <property type="entry name" value="ZCCHC17_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15838">
        <property type="entry name" value="NUCLEOLAR PROTEIN OF 40 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15838:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="S1 motif" evidence="3">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29039" checksum="16DDBF2FC28EEDC0" modified="2017-10-25" version="1">MAACQVNQIFLGEISSVQNYGAFVKIPGCPQQGLVHRSQVSSAHVDDVGEVLQRGERIWCKVISIGEDGKIALSMKLVNQGNGKDLDPNGVQLQLDEQRKKQMGGRQERKAIVLDAVYKTVCTKCKTAGHLAKDCFTTPDGKKYELLPEIDEEEAVPQPVNNLEAVDSESRSKEKKHKSKKSKKRKKSKTSKNNDSDSDDSDSSDEKTKKKKKKSKVKKSKKKRRRDNSSDSDSSDSSVSNYENKKHSKKCKHSRVRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4Q6</accession>
    <name>A0A232F4Q6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC30/dfy-1/fleer family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000972">
        <property type="protein sequence ID" value="OXU25665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4Q6"/>
    <dbReference type="STRING" id="543379.A0A232F4Q6"/>
    <dbReference type="OrthoDB" id="10249577at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000186">
        <property type="entry name" value="Tetratricopeptide repeat domain 30A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039941">
        <property type="entry name" value="TT30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="322" mass="37648" checksum="17545C7EB0E4AB76" modified="2017-10-25" version="1">MLGFGGYEILSAYLYDFLDALITQQTSPEEAYRKFDDLANKHTEVLRKATKQVQEARLNHDENAVKKAVNDYEDALERYVPVLMAQAKIFWDLGNYTQVEKIFKKSVEFCNEHEIWKLNVAHTVFMQENKFKDAVGFYEPIVKKKYDNILDVSAIVLANLCVSYIMNTQNSEAEQLMKKIEKEEETVSFEEQDKKLFHLCIVNLVIGTLYCAKGNYEFGISRVMKSLEPYNKKLGTDTWYYAKRCFLSLFEQLAKQLVVLKDNTLQDCIQFFEHCEVYGRDIPTVLEPLFELQEMSPMPKAKETVTYEARYLKALFLKYQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4U1</accession>
    <name>A0A232F4U1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB/POZ domain-containing protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001014">
        <property type="protein sequence ID" value="OXU25483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4U1"/>
    <dbReference type="STRING" id="543379.A0A232F4U1"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048512">
        <property type="term" value="P:circadian behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14822">
        <property type="entry name" value="BACK_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18287">
        <property type="entry name" value="BTB_POZ_BTBD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000005">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000038">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000051">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000042">
        <property type="entry name" value="BTB/POZ domain-containing protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034091">
        <property type="entry name" value="BTBD9_BACK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="621" mass="70962" checksum="D4A3C5D70BDB67DF" modified="2017-10-25" version="1">MSAHHRLNPSLGEIEHTSFLSEDIGALYLSDDYSDVTLIVGGQRFNGHKVILAARSQYFRALLFGGLRESTQSEIELKEPTLPAFKGLLKYIYTGHMSLANQREEASIFVILDILGLAHQYGFVELEAAISDYLKEILNIKNVCIIFDAARLYRLEFLTKVCYEFMDKHALEIIQHETFFQLSSGALNDLLARDSFYASEIDIFLAVESWVKANPGVNADIVLQQVRLSLISVSDLLNIVRPTSLVSPEAILDAIAANTQTRNLHLNHRGLLLVDENVAHMRHKAQVLQGEMKNYLLDGDTENYDMERGYTRHTISDSADSCIIVKLGTQCIINHMKMLLWDRDGRSYSYYIEVSMDEKDWVRVIDHSQYFCRSWQYLYFEPRVVLYIRIVGTNNTVNKVFHVVSFEAYYTHHNEKLLNGLIVPSQNVATMERSACVTEGVSRSRNTLLNGDWQNYDWDRGYTCHQINSGCIQIQLGQPYMIDSMRLLLWDCDKRSYGYYIQVSDNLKNWELVVDKTKEACRSWQTLRFSPPRPTVFIKIVGIHNTANEVFHCVHFECPAQINEIKSPNSQRIKELPSNEDFEQPPPPPPLPPPPPETATEAVNIDQEDNASVDGYGIEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5L7</accession>
    <name>A0A232F5L7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000948">
        <property type="protein sequence ID" value="OXU25778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5L7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="10352" checksum="081975F3A9793B25" modified="2017-10-25" version="1">MGVHVRYIREGRVTAQRFNTFDECSSKKVWRQMAKEMRRMKNEKDRESQQGGHAKTEAAPTLALKVKDRIKERKRELRVRVKKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5M8</accession>
    <name>A0A232F5M8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000977">
        <property type="protein sequence ID" value="OXU25647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5M8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="51" mass="5722" checksum="71C9208FA52AFC98" modified="2017-10-25" version="1" fragment="single">NFIVQTAKIRESRQFVTKLVLIRTVRLAHERSESDKPGAKKGLLSTQIGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6G2</accession>
    <name>A0A232F6G2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000799">
        <property type="protein sequence ID" value="OXU26446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6G2"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10446" checksum="76058B0947892147" modified="2017-10-25" version="1" fragment="single">ILVNLNNPLELSRYIMIFIGLMMHMFYVSYPGQQLIDRSSGIFNDAYNNEWYECSIKSQRLLAFMMLRCTKPCELTAGGIYTMNLENFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6G4</accession>
    <name>A0A232F6G4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_004116</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the syntrophin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000802">
        <property type="protein sequence ID" value="OXU26434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6G4"/>
    <dbReference type="STRING" id="543379.A0A232F6G4"/>
    <dbReference type="OrthoDB" id="9975356at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06801">
        <property type="entry name" value="PDZ_syntrophin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000193">
        <property type="entry name" value="Syntrophin gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041428">
        <property type="entry name" value="PHsplit_syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18012">
        <property type="entry name" value="PH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="43"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="130"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="220"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="386"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU26434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="827" mass="93495" checksum="DA5B568730A83F3B" modified="2017-10-25" version="1">MNWKKYEETFLCTTVDAATEAGKNFDTMNHQSVNVSTLLKLNTNDAREFLCGWGAAVINVTVTYPVNKVIFRQILEGVPATTAVQQLSQEGVKLLYRGILPPLCQKTVSLSLMFSLYEGCRQRLYVLTDHKTFAKVFAANFAGTCEAILMPLERVQTLLQDWRYHERFKNTPHAFSILLREYGISECYRGLVPIIYRNGLSNLMFFTLRDKSKDILGNDTTLLANFISGALIGGFTSTFFYPVNVIKVHMQSKIGGDFEKFTKCVRDVYISRDRSLKSFYKGVHLNFMRSFISWGEQQCQQQQQSQARGGLRRSMRVNPTKMCTPIEEKVEQNLKVRTGMVAVSDGKIKPIPTRLHLTMEVLKLQREDLEQSANHNKIPADTKERMVQITRQKVGGLGLSIKGGAEHKLPVLISRIYKGQAADQCGQLFVGDAIIKVNGEYITACNHDDAVNILRNAGDIVVLTVKHYRAAKPFLQKTEKEEKLDNASNGAAEDGWVSPSKLVASSPKASGHSRQGSNASTSSTKQKKWVDIVTVPLMMAYVTRYIFGTDKLRRNAFEVRGLNGARTGVIHCDDTAILSQWLKYIADNITSLTYLQMKLYNRNFGVGERIEYMGWVNEAVSNSNQLWQSYRPRFLALKGPDLLLFETPPCNIGDWSRCALTFKVYQTLFRVMRESENVDERQHCFLVQSPGKPPRYLSVETRQELLRIEAAWHTAVCSAVTHLKSKTFPITLNGRAAGLTLDWTQGFTLTFEGTTDPVWRYKFHQLRGSSDDGKSKLKLHFQEHDSIAIETKELECSQLQNLLFCIYAFITARVAAVDPTFLRSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F738</accession>
    <name>A0A232F738_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_007957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000758">
        <property type="protein sequence ID" value="OXU26651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F738"/>
    <dbReference type="STRING" id="543379.A0A232F738"/>
    <dbReference type="OrthoDB" id="10019582at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF15">
        <property type="entry name" value="URONYL 2-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012330627" description="Sulfotransferase domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33022" checksum="6E09E267F2F241A6" modified="2017-10-25" version="1">MRRCRGISVLVCLLLTTGFVLLTSKLILVEDDEAYDDFSAGAVENSYQSEDFYETEATTAARTTKTYKMQKYVTPSLAELGERGIPPETNDHVLMVTRVPGAGAELLVLILQRLQGFNAFKHIRLPPGDEGTLSNLQQELLVEEVTSIIRQEAIPLSFDGDVRFLNFSAFGRQAPTYISLVRDPLDPKTLERERNNEWALEQAKANVLRWYPIVGVLDLMDETLNSLERAFPYFFEGASLIYDKLRPKKKNTFSSTLKPGTKKRLRSLLKTEVKFYEWIKSRLLNGTTENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7G3</accession>
    <name>A0A232F7G3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000768">
        <property type="protein sequence ID" value="OXU26615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7G3"/>
    <dbReference type="STRING" id="543379.A0A232F7G3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU26615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21311" checksum="A7CC2065411A4BAA" modified="2017-10-25" version="1">MTKDNNHLGRFELSGIAPAPRGVPKIDVTFDMDANGILHVTAKDTASGRSNNIRITNDKGRLSREEIDRMLADAERYRSQDEEQREKVSARNQIESYVFSVKQAVQDSGDKLTQSDKDSVLSLCDETIRWLDNNTLAEKDEYKHKLEELQRQCGPIMTKIHTGGASGPQDCGNQYRQEAGGNSGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Q3</accession>
    <name>A0A232F7Q3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methenyltetrahydrofolate synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000792">
        <property type="protein sequence ID" value="OXU26478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Q3"/>
    <dbReference type="STRING" id="543379.A0A232F7Q3"/>
    <dbReference type="OrthoDB" id="433414at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017:SF0">
        <property type="entry name" value="METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="65194" checksum="A3A1BBCE56E75574" modified="2017-10-25" version="1">MSENKEESPAKKPETTVATTAETPAESPAKTTAEKPAENPEKVPAEKPAENPEKVPAEKPAENPEKVPAETAAEIPAKAPAETPVENPAKALSETPTESPVIAPAETPAKTSEETPAKTPAEAPAVLKTKQDFRKKVWCHMAEKRLSNSFRSLCSRTPFFKRATEATKRLCELEELKNSKLLMISPDKFVILLPLKKEKEILIPTPRLFNGLFSHIKNAAGLPEEESKNVITRNNIRQIESPVNFDTTTDLKVDMLILGSVCVNRAGYRIGDGAGFADLEYAILSKMKAVNEKTKVVTLVHDCQILDDLPNELFEPHDVPVDIIITPTQTIFVNPRLPKPTEIIWPAISKRRLAGMPVLGEIKQFVEKEGKVVTLKEEDSDEESRSKERIRVKKMISELQQKYRRSRSRPNSGIKENGTTEKDRDVRKRPYLRKRRLRKARDNNDENNDSENKSTENRTNAKIPRPARRFTPRNHVNFSLRLSNIASTVRVRDLKNALIERGVKPTNITWRGQKGFCYLHFGKLRNKSISPEEQQPVQVDSIVANLRQLKIGKAPPAGENGFIVVEPAEPVTRIEVTDVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7T2</accession>
    <name>A0A232F7T2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_000382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000743">
        <property type="protein sequence ID" value="OXU26725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7T2"/>
    <dbReference type="STRING" id="543379.A0A232F7T2"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="816"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="914" mass="105487" checksum="25B4967F712E960B" modified="2017-10-25" version="1">MEESMLKFDIKEVKSDLLKAIAECSQRGLMHTTKWLAELNYSLKNIKLDPSDTPSDISIAEPSEEEDIYTLAKSYFDLKEYDRSAYFLNSSNSAKARFLYFYSLYLSDEKKKIDNMTDVPSDLLKNSSLKHLCSELRKEHIAENLDGYGLYLYGVILKKLQLAKEAIDILVQSIHKQPMHWGTWLELESLITDREKLEALVLPNHWIKRFFLAHMYLELQLLDEGLALYCDLQAMGFRKNGYVLAQTAIAVHYRRDVDNAIATFKQIIEDDPYRLDNMDTYSNLLYVKELKNELAYLAHRATEIDKYRLETCCIVGNYYSLRADHQKAVMYFHRALKLNPQYLSAWTLLGHEFMEMKNTNGAIHSYRQAIEVNKRDYRAWYGLGQTYEILKMPFYGLYYYKQAQLLRPRDSRMVLALGEAYEKQDRIPEALKCYYKACNVGDIEGMALIRLAQLYEKLGHHDNAAAAYTDFVTDEYRNEDRTELSHAYKFLTQYHLKREELDQANHYAQKCLQYDETKEEAKAFLRTIAQKRIKVEENPMVVEDMNETDPIGDTENRAVATTPAGSQLSPMNLSFTPTHPRALTAQQPRSSSILTFMPIISIITSTIFAISSHRPRSSCCGEGDECRAFPRASLLSSCRRRLRRLDISVSRYSNNCSWNFKSNSSSRACKTISGSFKFNNGNNRLNSGNSARCPACRKSIIVIMITGTSQDAVLNESRHSQDRSPTETSLCELNKLQVFSEIQNLELLTSPKFNDFPQDLKEYLRSERMILADVRSIIASENSDILQSCNENNEEKKATVDVRSLENKTYANILQSGPRYDLNSSPTSDEHSCDMKPLQATRRYNRRSKSTNSGHNVNEIQTDHNEASNSALALETRKRTKAPYKFRKQSNYNKNSKIYDDSWQVETLSRKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8B1</accession>
    <name>A0A232F8B1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sex-determining region Y protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Testis-determining factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_015815</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000703">
        <property type="protein sequence ID" value="OXU26895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8B1"/>
    <dbReference type="STRING" id="543379.A0A232F8B1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="118"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="118"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="532"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="672" mass="75134" checksum="D20476D7EB15B8D0" modified="2017-10-25" version="1">MEKQKVLLSFVEKAPAASKSAPRKHEILALTADGKRLVRLQPEAPISVKQSKCQLIGVLMEKNNYEETSSRRQIRIESKSEIAPRQQLEANDENSVLTSGKSEDETDGRNSGGAKLKIPRPANAFMLFANEWRKKLAVENPKESNKDISVRLGVRWKTMPKELKEKYFALAREVDAEHKRKYPDYVYNPKEARLRKAMREQNRTQQPPAVNGPVSSGPTGTSNGQHQQTVSPLPGGGSSTIAAANRIIGPWFPLGHTNSSPPATHPKPILSPRVMAAHQRTLDKTKDVIRKQLQDCVPSNGPFPTGPSAYPVNGAQESSSDYCGEFAAEGQQQKWHPYQNGVNAYHSRGALVSKMNSLHRSMQNAPPHSNPRAWGQFCNVAFPTSQSAMMQQQQQQQQQERSNRHMVFLQEQQQQQQQSHCGYPTAEMRMSYESKMQDDLARRLHSSYSQDEQQLSRLPGSEEQKAEEPWTTTPRPTSSSSSCTPDGLLESESTPTTRASKQPLPGFQQAFGSTEIGRFSRSELFASLVEAVNVSSKSEELPSQFDNGRSSSPDYSGYNGSPLIPTKSLLKSRSAHPYRTSPDDPTSHRTKPPEFSARPSTQCAAVKSESLEAQEWPTAREIQPPPAHSQSHSFARPTEDDKREEHQQDDGLDLRVPWKKRKIKIEDTKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8L7</accession>
    <name>A0A232F8L7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000692">
        <property type="protein sequence ID" value="OXU26952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8L7"/>
    <dbReference type="STRING" id="543379.A0A232F8L7"/>
    <dbReference type="OrthoDB" id="8951118at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF129">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="130"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45443" checksum="7D04FFDDF7C47262" modified="2017-10-25" version="1" fragment="single">MASLDDAVRLMQAPKAVENDPCVYVFCDVRRKNCYRNMCAEFAKICLTGQPAFSKQRSMFTQEPHFFLNPKMRDEAALVGSPEDLFKRMGVRFLLFLSLVPFRVGAPDLCSLADKGAFFDQCVRDVASGRLAPVYWQNTTPASVGITSRFYELSWHHHPARNPDALTAFGVNEPSVYVSGRYALTDLYVEDNYLDSANVIRFGEVGSGKVWLLVHPRSFYDLTVALGDTIGRLRVLGRDDVFDYLEGCPTPANHKNISITSEYLQAREVPHQFITQLPGDLVYVGEGIYHQVINLGISVAEAVNVGSPRWNTGADRFVICCCPSNAVGYVPSNLTVTAVVRDRSFRRHVCPTDGCPFTTALLPHMRAHAQVEDDPNGSSKHHACSLCPKLYKQKCHLTRHDQIAHAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8L8</accession>
    <name>A0A232F8L8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 19 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_011931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000716">
        <property type="protein sequence ID" value="OXU26830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8L8"/>
    <dbReference type="STRING" id="543379.A0A232F8L8"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 19kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16603" checksum="118B978B1529A4AA" modified="2017-10-25" version="1">MAPTWEATKNHSDRERWICIYPAYINSKKSLAEGRKLTKEKCVENPTHQEIRDVLLSVGLNVGVENKLHPRERSKELLYRGRIRVQLKNNDGTPFNPDFPSRDSLLSFLGTNIPKLKSRQGKQAAGEQSAQQSSSSTSKKGKGKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA94</accession>
    <name>A0A232FA94_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_013821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000616">
        <property type="protein sequence ID" value="OXU27379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA94"/>
    <dbReference type="STRING" id="543379.A0A232FA94"/>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13582">
        <property type="entry name" value="Reprolysin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353274" description="Peptidase M12B domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="208"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="626"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="854" mass="96250" checksum="6642BACD2369851B" modified="2017-10-25" version="1">MMASKLLVLALCLNSALIFAAQGGKIDNRLSDAEFRRIFHRRRAEVPDYKTVMLETSNGHRSRRELRPVEFDIDGTKVQLHLNPIKDNVMNHVPVWTVETDRQSSTGHRYQKLPEEQTRIDGTFYQDPEKAATLLAYYKNQYIYYDGIFGESKMAKIVRSVPEKWWMTPGKGAGNDHVVFDVNENKGTTKPVGDSSDAEKLDEPLDVLYPKLLIVVASDYFKKFGEDVSETIKYVSTFWNAVNLRYAKLTAPKVKIIITGIIIAKDDTALTFVYNSRLPEDMNSLNTYQLLINQGQYFEKEFNKSLDFQNYDSTITLTNLNTGPIAGSAYVGRICHVGANTGFVNDDASYGGLQPATHELGHLLNLPHDGAGAAKSCEPYPDSNTSTIMAAFMAYVEKYIWSDCSQRILREFATTKAAECMNKFFVLALCLNSALIFAAQGGRVDDRLSDAEFRRIFHRRRAEVPDYKTVMLETSSGHRSRRELRPVEFDIDGTKVQLHLNPIKENVMSYVPVWTVETDRQSSTGHRYQKLPEEQTKIDGTFYEDPEKAATLLAYYKDQYIYYDGIFGESKMAKIVRSLPEKWWMTPGKEAGNDHVVFDVNENKGTTKPVGDSSDAEKLDEPLDVLYPKLLIVVASDYFKKFGEDVSETIKYVSTFWNAVNLQYTKLTAPKVKIVVTGIIIAKDDTALTFVYNSRLPEDMKSLNTNKLLINQGQYFEKEFNKSLDFKNYDSTITLTNLYTGPIAGSAFVGKICDDGYNVGFINDDASYGGIQAATHELGHLYGFLNFLILNLPHDGAGAAVSCEAYPDPNVSTIMAAFVASVEKFVWSDCSQRILREFASTKAAECMKYSSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAB8</accession>
    <name>A0A232FAB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011297</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000540">
        <property type="protein sequence ID" value="OXU27794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FAB8"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="849"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1165"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1202"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1243"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1284"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1366"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1455"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1485"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1566"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1639"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1676"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1757"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1843"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1884"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1961"/>
            <end position="1979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1987" mass="227036" checksum="63A3B45049B1FA72" modified="2017-10-25" version="1">MFLPSNTADKLLFLIKLFIIILIPTCGKNIHVIVAWQTSPAMRRSKCDDLFLKCLFYVLKFLGVAPIAVDNSPTPEKDSPRYVRFVASKLAVFYNGILACLTFYPSYMTVRYLTSSEYTKNIELKKVIDEAQSTFAMITSTFIIVNICVRQKRAAILANQLSSIHSVIMDLAVNVRRNTIISYIKKIVFVNLVTTIIWVASTPPEEYQYLGYFIVMSFYNIIIHAMLLQYSLVLKLLQQLYRSVNADLSSLLKKSSSISDDNNCHLMLKRLKHLRQIHATLCQISQDVSNFYSLPMLFCLTHVFLTQIIYCYYVVMTLIVWNINEKPILVILNCVTLVTLLAVSMTILVRAAGVTVVESKSTGEIVSGSIDDCQDHEIERQLNAFSNYLLHKDVHFSVFNLFPLNESLLISIVGSITTDFFFLKCLFYGFKFFGIASMSIDTNSSDVKINNAPKEVHFIYSKLGRFYSAILMLLSIIPSYIAIKQTYQIDYTDRIQLERGIDVMHVVGMLVTFYSIQISMCFSQKKAVAIANQLSSICSRSMNLSTKSKVRPDPVFQSVKKIVLANVGLMLFSSALSFAFVDYDLIYHLLLNFTNVTIYAMVLQYSLVLKLLQHVYRSLNADLRSFLITRGSSRILLPTYGFQSRLKQWHEIHVSLSCVSQDVSYFYSRPMFFTFMIAFFTLVLFIYYCMVVLLLMSNDLSYGLLLLFFFTIVVLVILALWTLARTAGDTVRESKVTREIVSESIVYQCNQPISVQLRDFLHYLQQKDVNFNIFHLFPINESWVMSITSSICTYLVILLQSDFLFLKCLFYGFKFFGIASMSIDTNSSAVKINNVPKEVHFEFSKVGRFYNVILVLLSIIPSYITMKQAYQIEYANRLQLERVIDVVHVIGTIVTYFILVSVCINQKKAVAIANQLSSIYSQSASLSTKSNIRSDQVLRSAKKIVFTHVVLAILSCGFALTFINYDLIYHLFIDFTNVTIYAMALQYSLVLKLLHHIYRSLNADLRSLLITRVSSGILVPSDGFQSSLKQLYEIHVSLSCVSKDVSDLYSLPMFFIFVIAFFTLILFIYYCMVVFLLMPVELNFDFVLPFYLTLLALVIFAMWTLARTAGVVVKESKVAREIVSESIVNQGNQPISRQLRDFSHYLQQKDVSFNVFDLFSINESLLMSFASSICTYLVILLQFKESNSMQMLCKPHYTSDVFFLKCLFYWFKIFGTSPMGIDSMSVVKSNNVPQYVHFVFSKLGILHNAILVCLTIIPSCVMIKEAYHTEYTDRLQLERVIDTVHAVATIMTFYFILINVCINQKRAVAIANRLNSIYSQSTSLSSKSKLRPDPDFRSVKNIVLIHMVLMLFLFLFAFTFVHQSLIYHLIINFTNVTIYAMALQYSLVLKLLQHLYRSLNADLRSFLITRDQFDPSGISLPIDELQCRLKQVYEIHVSVSHVSQDVCDFYSLPMFFLFAVAFFTLVLFFYYCMLTLLLMNEMIDYGLVLAFFLTMLGLTILAISTLTRIAGGTVKESNIMREIVSESIMNQRNQPISGQLRDFLHYLQQKNAKFTVFDLFPINESLLMSIASSISTYLVILLQFKESNSTQQTNAMFIKCLFYAFKIFGLAPMAIDTTSTAKNNKEARNIIFLSSKLGVLYNAALAILITLPTYLAIAFAYSDYIGRLEFEKITDTIQSVFTIFTSVFILINVCVRQKRAVDLANRLQTVHYLSMTKVGCSDKSVKLLSSIKRVVLGNVVTTILCLAVTPSNETRALIYFLVINVHNTIIQATLMQYSLILKLLHHIYRSLNSELSSLNKSLIFVSEFNQFLNNSVQTILRRLQTLWETHLLLSHVSREVSDFYSLPMLLCLSNAFLTLIIYSYHFVRVLFIWKVHSADTIVLILRTFMQVVAVAVSLTILTRAAGLTVSESKRTGEIVSESTVYGHNRQIRSWLKEFADYLLHKELKFCVFNLFALNEELVMSIAGSIATYLVILVQFNETSSIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAC8</accession>
    <name>A0A232FAC8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome activator complex subunit 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000571">
        <property type="protein sequence ID" value="OXU27615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAC8"/>
    <dbReference type="STRING" id="543379.A0A232FAC8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="1">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="273" mass="30865" checksum="2344BA47CA66F8D0" modified="2017-10-25" version="1">MICKWILETVMLSNLDNLSSFYKIYPIMCQLESNEKDEELSKACSRTLAVLAQTLTHPHHVPAALEAVTAISKSTSWSARASCLEFLQVLVFHNMSILLSNEAWISEIQNIVLHLLEDERLEVREMAAKVLGGLLHCTILPNEEALLDEFKKKARTKLGNKRKRMSEKEEEKSGVTNKIINAARLRHAGVLGMCAFIQAHPYNVPEIIPPIFDCLSPHLNDPEPIPSTIRKTLNDFKRTHCDAWTGLQGLAERFTEEQFALLQDLTVPPSYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAG0</accession>
    <name>A0A232FAG0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000533">
        <property type="protein sequence ID" value="OXU27834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAG0"/>
    <dbReference type="STRING" id="543379.A0A232FAG0"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07852">
        <property type="entry name" value="STKc_MAPK15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000166">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="752" mass="84673" checksum="180178DB806CEA71" modified="2017-10-25" version="1">MSGKKSANEKLSEIDSHVTKHYDIIRRLGKGAYGIVWKAVDKRTKETLAVKKIFDAFRNQTDAQRTFREIVFLLSFADHENIIQLIGLHKANNDRDIYLVFEYMETDLHNVIKRGTILKDIHKVFIMYQLLKAIKYIHSGNVIHRDLKVRISASPSVHYLQEVDSKLNSAHRHNIRQSVQPSNILLNAQCHCKIADFGLARSVSQLGEGDGEAGSDPTLTDYVATRWYRAPEILIASRRYTKGIDMWSLGCILGEMLLGKPLFPGSSTINQVERIMATLPPPTDEDLASVSAGYGTSLLEKAPTSPHRSLEELLPNVSREALDLINNLIVFNPNYRLTAVEALEHPYVASFHARGNEPARGSSVVPFLRDDVQLSVDEYRSKLYSMMDEKHRKHHKTTSSKSRPRHLSEHVQRKEPSATANATADCAVPPRKSFHLSCDDLRREKSKSDTYKALFLEGESRQSLAGKKPSINGKESRGGQLASTTTSDKISRQDGMNIFQPRIAILVDRNIQRDTNNSTAKYSSAPTIKPPSKNMALQYAYNLMNGNFRNFGTTSQAKSCMYLNHQQQQQQQQQQQMSRSQRSIQSDQYNRATVGYGPNSQQAKLRRACGGIGSTIGRSTITQSQQCRPVTSFCGQPQTRLEKRTSQDSPPVLCSNKYITRLPQDVRRHMVPPEAGDHHSRTIRDYLNHQRHQPQSRYKSADSSLLRSSQHSLNNNIINSKLSSGKNVGYYAQSHGVITASMYRELRSGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBN0</accession>
    <name>A0A232FBN0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_009642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01000460">
        <property type="protein sequence ID" value="OXU28231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBN0"/>
    <dbReference type="STRING" id="543379.A0A232FBN0"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="140"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="343"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU28231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="457" mass="51695" checksum="4F6ED8EA9A9B9066" modified="2017-10-25" version="1">MGRYRSRSRDRDRRRRSRTRSRSRSPLRDRRGWGGGGGLRDRGGGRNGRSQPGANLKKPRWDMNRLEPFKKDFYVPCDSVQNRDPRSVEQYRSEKEITLKGKGIPNPVFTFEEAGFPEYVMREIKRQNFKEPTSIQAQGWPIALSGRDMVGIASTGSGKTLSYILPAIVHINSQPKLCRKDGPIALVLAPTRELAQQIQQVADDFGHSSGIKNTCLYGGAPKGSQARDLDNGVEIVIATPGRLLDFLESGRTNLKRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQTLMWSATWPKEVKNLAEEFLKDYAQINVGSLQLSANHNILQIIDVCQEYEKEIKLSTLLKEIMAEKENKTIVFIETKRRVDEITRKMKRDGWPAVCIHGDKTQQERDWVLQDFRSGKAPILVATDVAARGLVKLIQASTTKAESEEGELSGWMFVCIAEAHCAQAHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBQ8</accession>
    <name>A0A232FBQ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000458">
        <property type="protein sequence ID" value="OXU28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBQ8"/>
    <dbReference type="STRING" id="543379.A0A232FBQ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="503"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="78811" checksum="9EDE5F2DC56FDC93" modified="2017-10-25" version="1">MTSGDVGTIKAIKSCKFKWEIHNFSSRCKKDGDVLKSPKFRTNISVISDIGCSLYCEEKDNKDYLSILLLANFEIKVVVSFKIFTNNGDLVVDQTLDAHGSRYTRWGRVKFITLDFVVNPLNDVLNNDKLTIEFEITETDNETEDKGDVVDDYEALLSDDKFSDVSLVAEGKTLKAHKCILAKRSSVFATMFDTDMKEKQGEPVEIEDVKYDVLVELIRFIYSGRVNNIVAIVDQLAIAAEKYALDGLKKMCERIMRTNLSINNVIGCLQLADRLRMDELKAEAIELLLDNASDVSEKPEFDLLSDDIVRKVFRCLAKKKMSEVEQFYVTSYTLKWEIENFYKRHMEQEIYFQSPAFRPNFGIDRDIRCLLITFYCEDKSEHYLNLVLFGLGVENEVHLKIFNSKGEVVVNQNLLDKQIGVSKLGKIFTDFEQISTYAEFYFQNFTFDPVNDMLNDDKLTVELEITVKNNKTNLQKPENLEAEKRENDIVEALSALFNDDKYSDVTLVAEGRALKAHKCILAKRNSVFAAMFDIDMKEKQKNTVEIEDMKYDVLVELIRFIYTEKVNNIVAIVDELAIAADQYAVDSLKKMCEKTMGENLSLENFVGCLHLADKLHMNQLKQDVIMFIFKNASDISDKPEFDSVPDDIVRQVFRCLAKKIEEIDDTHKQCRKQLKKFCCLARKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCS6</accession>
    <name>A0A232FCS6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_013355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000427">
        <property type="protein sequence ID" value="OXU28475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCS6"/>
    <dbReference type="STRING" id="543379.A0A232FCS6"/>
    <dbReference type="OrthoDB" id="6606209at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012986011" description="Cadherin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="171"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="422" mass="47376" checksum="1EF458766EC746D7" modified="2017-10-25" version="1">MKVLNSALLAVYLLVSLFCEGISGNKPSCKIYHENSEKLFSEDEWNRGLELGKLNDDTAVGILKTYKTANISKILTYKVSGHDNYLTVTKPTEKDEFYIEIRDNFDQYEEKETAETMSLEIKFACDDNESRILKIKIPLRDTNNHSPQFLKSKYEYKLAMPLPKGFDFDTIDQIAVRDVDLTNKAIDFAIKGDEKYTKGFLITSLGRTKEDKKNFTARFITSMIIDFEEDTTFTLSATDAGKPTRTTETNLTIVVDKANSFPRFAEPEYVADLKNLDYGKVKKIMLNFSNGNDITLDRGFEGPVNFSLSGLSEENKKHFKLSSKGSKVQIELSDLSDTFLSQGVISAALTATKETTETSTAIIVLLPEVPVSKATETSTTVKPQESKTKDDSVNGYMVSTIILSLTTVGLLGYVIYLHFYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCZ1</accession>
    <name>A0A232FCZ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_008310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01000442">
        <property type="protein sequence ID" value="OXU28353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCZ1"/>
    <dbReference type="STRING" id="543379.A0A232FCZ1"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000096">
        <property type="entry name" value="Ubiquitin thioesterase OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="111"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="310" mass="34167" checksum="04CB3B9039C5FFB8" modified="2017-10-25" version="1">MGGFVLRVKSKTGHKIVDNLMPQDTVTKLKNKLSEVTGVKIDALHVLKGFPPKPLDLSNGNATLQESDITSGETLIVEEKQVVCNGEQRVQETPRTHITDQDDFANCPGVLMKMVVPADDSCLFTSVGFVLNGKVDPSCAHMMREIIANAVSRNPDDYCEAMLGKPNREYCEWILKPNSWGGAIELSILSKYYGLEIAVVDSSNGIINRFGEDQQYATRVFLMFDGIHYDPLYLEPLDGGSIQSMFPTDNQVILHQAANLAQEAKSSHQYTDIQKFTLKCLICDVKLSGSEAAQKHAKETGHQSFGEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD65</accession>
    <name>A0A232FD65_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein POLR1D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000414">
        <property type="protein sequence ID" value="OXU28572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD65"/>
    <dbReference type="STRING" id="543379.A0A232FD65"/>
    <dbReference type="OrthoDB" id="6352295at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038948">
        <property type="entry name" value="POLR1D-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34769">
        <property type="entry name" value="RCG42593, ISOFORM CRA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34769:SF1">
        <property type="entry name" value="RNA POLYMERASE I AND III SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8891" checksum="44A80CCA6C26F316" modified="2017-10-25" version="1">MDEETLNRLAAEALLEEAKNGARRAAVMGPSGWIKKKETINKRFLHSTLRNAVISNRYKTNSSKIKESSPPRKPPNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE80</accession>
    <name>A0A232FE80_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000388">
        <property type="protein sequence ID" value="OXU28739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE80"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="138" mass="16471" checksum="64134176DBCED8FC" modified="2017-10-25" version="1">MLLLRDMVLYLRSFQKTMLILSTLDTRYLESDYRHVIRIQSPQKPPIRVSTKYVVILRETPGDDVDIANLWRRETTLIIFTLGTGYLEERCRRYIRVHQPRKLPSNEFRLIMFQIVTKLQETINTVYPGHQVLLRVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEC4</accession>
    <name>A0A232FEC4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_004268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000337">
        <property type="protein sequence ID" value="OXU29101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FEC4"/>
    <dbReference type="OrthoDB" id="75250at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023341">
        <property type="entry name" value="MABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF30">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN CRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51498">
        <property type="entry name" value="MABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP" evidence="5">
        <location>
            <begin position="59"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="UDENN" evidence="4">
        <location>
            <begin position="207"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="862"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="961"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1634" mass="184744" checksum="8F6FA4B3710FE5F7" modified="2017-10-25" version="1">MDERRVADYFVVAGLPAQDEDEVVPDIEKRDENEGKGENGWKLEDWCQEGTHVKDTNLQAPITDLAIIFPAFGETCPEGFSLLEYTVTGFKADLNHGSLRTEECYLCYRRGRDKPPLVDIGVIYDGKERIMKDAEIVMKTPTGQVANVNNSTSRIFVTYRRANRKMPCNSLVVTDVCVILANKGESPPHAFCVISKNLNKGMLGSDVYLCYKKSMNRANLISFKPAILYKYPTTDYDSFGFPNSVAMFCLPMGATVECWPKIASKPKPVFSTFVLTVADAAQKIYGSAITFYEEVVPPDNCIIENEIITENTEVPENETEDTTEPSEIITSKPQLKKKVFKKFGILKKLNQSQLEKLQFTDPSTQSLNISKSICILSHWPFFDTFERFLVFLHGLVNRQPQNVPIEKYISYFLCDIPFPSPQRPRIFVQLSSQDRLILTQPEDLALPRSGASFRQLLINLGADNCMLILLLILTEQKILVHSLRPDVLTSVSEAIAMILFPFKWQCPYIPLCPLGLAEVLHAPLPFLIGVDSRFFDLYDPPSDVNCVNLDTNNIAICDDKKHLNNKLLPKKAARMLKNSLEKLHSKLVSINNAHMQERCASTVEDKDFSVDKEFQQKRREQTLELEIQDAFLRFMALILKGYRGYLLPITKAPTVGTTDPTSLFNIQAFLRSRDKNHAKFYSMLVRTQMFIRFIEERSFVSDMDMAGLAFFDECTERVEEENVMLLELDESQHSERTVFIPPPEPDPNQPPILYKTFELDSKLMRPQKNFHLRNVALNTFGIAPGSPMARRTKHEIKVAQRMARKQAALPERWGRCLLNTCYSLWFLHLPAMLQVSSQPANLLHQAYELLVKMQKLRLDPMEEVCYRAMMQLCGVYGQPLLAVKLLFHMKRSGVQPNALTYGFYNKAVLEATWPSDMTNSSQLMWNKLRNVIVGAALFKKAGKKSARRRLSCNNETLLSTDDLKNQNMEHAVSRSSLDSTHSQDTETAHSDSLKDSSIPDLPTFGLKEKKHLPRQNSIVKDTAILSDSQPEALDRSPSDPRLVRSIESPVKSPVRTPVTENDPLGALANDDTPIVSPCEENDSNCSTSTLTVLNNAIEDSRPGGPLLFRNNILPRSATFHQAEEAGGGASVGGHLQRSETMPHSVQQAEQERERERLELGSLWAQNKDSVTSSLSSIGSSLKLSFGRYSTGGLAFAKNKDLISTNQLIESLSLSSYISPSSLTGKKSNEIILGGLNSLKSAATTVVKKFDEIKEAISATSTPVKLKERDQQRMNYGVSHESLDSLTDGSQQDRNELTARMAGEVSVDLGSLYELAECLYPKGSRELEERFAVELILSSASRCHNCSAILYDEEIMAGWQPEDSNLNTTCQFCDKATVPLLTVTILDYRCEDGESSHDPLMAGLLQEPRELPEPISVPYLNPLVLRKELENVLSQEGDSCLTKHKFIQEHPIVYWNLIWYYERINLTSHLPELWLNRGDATNDPLVANCPHVGVRTLWDNEKLHMDKLPMYMQWKNNIEDRTFMQNVITYVRRNDLSEPIKRVALERNRNRSSEQTPFSIYRDILFLAFTVLGRGNIDQGTVNFTAFDENRAFDREYALSLEKLTEGEESLLCSIDAAPLLMTLYCRHYFKQLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEJ9</accession>
    <name>A0A232FEJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000323">
        <property type="protein sequence ID" value="OXU29214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEJ9"/>
    <dbReference type="STRING" id="543379.A0A232FEJ9"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF14">
        <property type="entry name" value="SIDEROFLEXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="326" mass="36734" checksum="03A1938725B3216E" modified="2017-10-25" version="1">MSNDRLDLDKPLWDQSTFLGRWKHFAWVTDFRTCVTPEAELHKAKELCEKYRLGKEPPGTTREQVIYAKKLYESSFHPDTGELQNVFGRMSFQVPGGMAITGVMLQFYRTTTAVVFWQWVNQSFNALVNYTNRNANSPVSTTQLATAYASATTAAMITAIGCKSFWQKRANPLMARYVPFAAVAAANCVNIPLMRQNEILGGIDLTDDEGKKLTKSKLAAVKGISQVVISRIIMCAPGMVLLPPLMERLEKRSWMQRIKFLHAPFQVLMCGISLTIMVPTACALFPQNCSISSKTLQKYEPENYELLKQNCKGGKIPEYLYFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFW7</accession>
    <name>A0A232FFW7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_006531</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000306">
        <property type="protein sequence ID" value="OXU29329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FFW7"/>
    <dbReference type="OrthoDB" id="8174258at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF447">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="842"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="234"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="531"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="846"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU29329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1403" mass="156029" checksum="4335C18132D5EA97" modified="2017-10-25" version="1">MSTSSSSSGLERVQYSADRVHRDNLKSAESIGGGGRRSTMKPNSAYVPHNRLSRYLAALSSLALVRFKSALGSELPLDKIGLFSSASFRWLNEYLYAGYKNGMKDKTLPSLSHRETCNDNGPRLEGLLHAHFVEKGQAGASIPQVAWHFVRTRVIIGSIIYFVGSIISLAGPIFVLREIVRATEERNAINTALSHVNRTIVINDTEVNETFREVFRTKESEIVMDEIIIFSHTGLLIFIEVVSQFLVSWSSSLNLRTACRLRSACLAVSYKKLLRSSLRCSTTAQQTLTYFVPDSEVLHELIGLGPVVVTGPTVLLLVSGFTWFALGNWALFGILLVVLLYSCLMIAAYFTKAFAARAIEYSLRRMSLVEEFVNNIQMAKITLWDQHFQSRIKDIRARELAEMQFGGFSEGCGLSMIHMIPVFAVSTITLVSLLIEKQISFVEYVPVLVLFLVNLKHCIRTSWMALSSISRGLAFLNKLKTILILQEADRFLDKPIDRNFAIIIHNGHFTWSKSKALALSKVAKRSSRFYVDSHDGNSSIEFNFPNSFVTTLSEIDFYVPKGKLVGLYGRQDSGKTSFLLSILGQLQCVGGTVAIDGSCSYVPNKPWLMDGTVKENVIFGENFDSSRYYRTLRASQLSQDISTMPEMDDTDVQVAELGPLQRQKIGLARAVYAQRDINLMDEPLKDLEPKDRVEVFDKCVLQLLASKTVIVASDRIELLSRCHVVYVMQEGKIVESGSHEELLQSNSQYARLAESQARSRYKKLSKSGDLPSSSPSVVQTPTTPKDFLSSLAASSYDSVHNNDEDGRPLYGRSNFDYPILRSFSEGRPKTGVGVYLKYTGGWSIGILLCVLSALYAFAIAIAPVCIVHVGQKTVDDMKLAVGVLATLVGFLIVCGAILTIAYNKTISLAATKLHDHWIESLGHAQISIFSSSTISLLLNICSLNLQEVDSILPRSIITILINIGVSLVSLVILSLLSSWLLLPVLAFVIVSMIFSVYVRGAVLCLHELKVSSATLVLNHIGNTVQGRATIQAFSKEKEFAKKYYKLFNENSTYDFMLYATRLWLEFRLKLLSVLVLSAVIFVSELLYSGVSNLPQLSLAYICTMQLTLSVLHTIGAINNVYTSLMALNSVDHYMKTIPKEREGTARLSSMWPTDGSLEFRNVLLFDREESMRKPLTFALASGDNLAVISSQAEARAAFVSALFRFAELPAGEIFIGGTSISQAPLHMLRRCICFIPGNPMLFNGTIRHNLDPSAEMADQSLMRVLQKVQLWEKVSKMPDKLVSDSCHLFTIYEKVLIFLARALLNERTKIIILEDPEVDVLNDRSDVLEVVLRSVFADYTVIRLSSHRIRSCQKFLTLDDELEDYNSDQGSSTLSQVTTTTELYTAIPAHIGLSSDGMSSETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFX8</accession>
    <name>A0A232FFX8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridylate synthase RPUSD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA pseudouridylate synthase domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_008567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Pseudouridine synthase that catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000259">
        <property type="protein sequence ID" value="OXU29664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFX8"/>
    <dbReference type="STRING" id="543379.A0A232FFX8"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000010">
        <property type="entry name" value="RNA pseudouridine synthase domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="360" mass="41299" checksum="18CF52ABA08E63B7" modified="2017-10-25" version="1">MFVEKEVTSLTIFSRERILRLYNSSGEQKVHPCGRYRHNTVVFILAKEYNLKNLRTIHRLDRLTSGILLFGRTPKKARQMEHQIRNRQVQKQYVCRVEGEFPEEEIVCSEAIEVVSYKIGVCKVSDKGKDCITKFKRLSYNGKSSVVLCKPQTGRMHQIRVHLQYLGYPVVNDPLYNHVVFGPDKGKGGNIGKTDEELVRDLIGIHNAENWLGMDGDSEMSLFKPKLDLDDRIPSDKEGSPSSTPSLSEDDQQQPQQQQQQQQQQAQQSQPQQQPAVQKSMKVTVGTQTGSEPPDSTFANEKVTVDPHCYECKVKYRDPKPSDLVMYLHAWRYCGPGWEYETPLPAWAASDWQPTEEQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG78</accession>
    <name>A0A232FG78_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000255">
        <property type="protein sequence ID" value="OXU29685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG78"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="12267" checksum="B552B1496FC2E118" modified="2017-10-25" version="1">MDLYNQIRRCIIRCIVFTVTILLYTYHLFIRSSAYAMEQNSTAIESNESTMGGETVEPELLHQLEDPTTLSRIRRSIINAPSRQNRDGSPRYRQDAKGVQRRIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGF1</accession>
    <name>A0A232FGF1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nesprin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000242">
        <property type="protein sequence ID" value="OXU29765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FGF1"/>
    <dbReference type="OrthoDB" id="6618337at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000171">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF1">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01249">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="8">
        <location>
            <begin position="1366"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="10">
        <location>
            <begin position="1336"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1395" mass="157891" checksum="53A333CB0FCD6AC6" modified="2017-10-25" version="1">MKCKHVCEDTLAEHKERLAELRGLVAQIASDVGLDAGGPLQSEVEALGRRLEDVRETLSSLADTADARALNQELARDDLCQTKNFLESVQQSITTVGQGESKEQLTLLRNHLLALTRTKPQLQSIKDRALEILPAREPSILEVLTIWQRVFRETFEQYHRLSARLIRSQDVAAALRLWQEYLSHVQDFLSTSLPGDYNGLAEHRNLCEVHKNLLTEQQKLILMVRSEEGRDLSLTEQFNALTNLHNESLASIMERHTAVRDRLAAWERYRIDQSKLLSWLKDIDRDRGRLQLRFIHVNRLEKILQRIEALLDRLPSGESQAXXXXXXXXALAVSVRMEHAASTQRLSNVRASLETWKDFVLRIRDLNGKHAEQTGKITAVFQEIHKAIGHMDKSSSGSLPQIRRQLDSLQQHKARLVACTSDLEALGVTTEQLRECLSPSDMKNLNQQSFLLWQQHGNLEHQLALLSYRLSERCSLHSRWESRSGRLLVWIKDIEDSLQNCDTANLDEPEEALRRLESEVQAEMALKQRELEWAQNNGLELISIAEPGEKERLVNVLDELNERWNGLLTAGKARANKIVDLMQTMSTLQKRLAEIRLWLGTVETQLSEAYTIESASPATIDKKLKDHEQLQKTIEAESGNVGEVLNLCEMLLSDCDAWKASFNTDAIKTGMEGLESRWKATCVKSSERKRKIMLIGKLLVELESIRLEYEEWLIKVEKQLEDLDKGLSNLSKDNTDKTMTRAQSILEDIKAHHPALHILEQCYSRLAKGGLEPDNLKALTAQTRQLIDRWHGLTPKINTIITALQRDQKTYREFISAHGAAVIGLTQVDVTLTQMQHLSRPDKNSSPRKRLQQLSDIDAELAKQSATLRRADELALQVMCESHPDDVASIQELVDEYQLLWKDIKERVDGLRARIESQQRQEVDEAVQVETLKFETDTAVQVDTLPKLTRMTSSDAYLIELEAAISECRVALDALESAVLPEPTPGTGLSTAARAIAKLIGSCQSTIELVKHLHNLLSEEEKLAKATEVAELTARYEDLLRRARAREQQIRELNDGGRLTCPLCSHRNWAQLDNDLWRLEKWLEFAEGTQSEQHSPPSNIEQLEDVIQDHHEFLLDLDSHKSIVVSLNIVGVHLADHTEDLERANELRDRLASANVRWDKVCQAASKWQNLLQAALMGNQQFHRIIEELLAWLESTEQTIRASEPIDLTEGAQILRDKYDKFKELQGDLERCEPRVLSLQEAANHLLDEHAETRERLQELRLRLQSLRRLTSMYVLKLGSALGLDPQDVGMAATSTSLAILSRDLLDEAASGTTQAHGTITANADDGDQTVLARGYHFIGRVLRASLPIQALMLLLLGAASLVPSAEEDYSCMLSNNLARSFTPLIQYPNGPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGJ4</accession>
    <name>A0A232FGJ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000229">
        <property type="protein sequence ID" value="OXU29864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGJ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="6775" checksum="8802929C5D4543AB" modified="2017-10-25" version="1" fragment="single">ADLAAAATLRFTGTKLDVVYFGRAHITRPLQFAASSSTESPRERTIRSNDRRAVFGKHARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGM6</accession>
    <name>A0A232FGM6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000248">
        <property type="protein sequence ID" value="OXU29713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGM6"/>
    <dbReference type="STRING" id="543379.A0A232FGM6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF6">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="25"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="350" mass="41083" checksum="ABBF1D23A00AED6E" modified="2017-10-25" version="1" fragment="single">EECKKKALEEYHDVECFILPFLLSKPFQFVDVDVIATTVRFFIRAVKSEGLQKVLTDSRLIDDKDGLHMEGLLSNEIYDNKKFKFCYNLLTHKEHTKQKIPAQEFYSCLFVNLLLKHTRLLDEYKIISNGDLRITNPTEVLEIKLTLCKITNILAVNIHTFQGSLCDCNYLSNCNDTCTGKRGQIFASCTSLINHSCHPNISRMFMPQRKVVVFTTCPVKKGEQLCDTYGPTIRYKNKIQRQQYLQNNYNFTCRCQACRENWSMELNKSDLTCFKKLDLKWYKNRYLKADSVQNWTYNEKTMQDVVKASELAYNSFNQNKAYVLSIPCRDYIEHAFYKFYEDDCHVPDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGR3</accession>
    <name>A0A232FGR3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000282">
        <property type="protein sequence ID" value="OXU29517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGR3"/>
    <dbReference type="OrthoDB" id="10406362at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940759" evidence="1">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="135" mass="15258" checksum="BC706DF3AB5010FE" modified="2017-10-25" version="1">MKTLFFVVLGLVAVSAVPVEHSFPQFENGTPKMKEQVNTCLRNYKIDPAVLELGDEKNFEKTDKLTKLEWGCVRACVYKGANFMRADGSLDMEVLTDGDEPEDKKKFESVVDICRAEAGKDDCKFFQCMDEKDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHE4</accession>
    <name>A0A232FHE4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FGFR1 oncogene partner (FOP) N-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000195">
        <property type="protein sequence ID" value="OXU30095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHE4"/>
    <dbReference type="STRING" id="543379.A0A232FHE4"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018993">
        <property type="entry name" value="FOP_dimerisation-dom_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431:SF9">
        <property type="entry name" value="CENTROSOMAL PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09398">
        <property type="entry name" value="FOP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGFR1 oncogene partner (FOP) N-terminal dimerisation" evidence="4">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="462" mass="51314" checksum="1D12FC8F04798500" modified="2017-10-25" version="1">MIDGNISMEEDTELRDLVVQTLENNGVLAKVRAELRASVFLTLEEQESVLNPEPFLNKSIKQYLANSEGKLLFSLVREFLEYFGLDYTISVFEPETYFGKEYNYVGRKKLSEELGINSSEPLLGEILKNTINGALNNTQKNDSSNIKLSNTSGAAENVGNATFDISVPKMLHKDEQESISIDTSEKLESLSNSNVQVPINVTITDKKQNQYSINNKKSNSLDMSDSNSNESNNKNLQNINDKSITLETDTDRSNKVLSETDKNINHSKLINSQPEMQKNPETNKSKKSMMEFQAVKNVKNTKQIDPMNNVGKTVFFDQMIVDGKQEKITEPKNDKTLLGELPPLSSTNNSIFGDLPPLNGKKANINDLKELMDIAQGVSQYDDDFPSSASGSANEQSPSKAIDKSDHHLKVQTSELESLQNLQSENESEEIDEEIPSSISGVDNIAEKNSENLSISAAVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ15</accession>
    <name>A0A232FJ15_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gem-associated protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000156">
        <property type="protein sequence ID" value="OXU30469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ15"/>
    <dbReference type="STRING" id="543379.A0A232FJ15"/>
    <dbReference type="OrthoDB" id="70763at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11677">
        <property type="entry name" value="Gemin7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020338">
        <property type="entry name" value="SMN_gemin7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14679:SF1">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11095">
        <property type="entry name" value="Gemin7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21452" checksum="F89637E36662E659" modified="2017-10-25" version="1">MNKLKYSLNWCDKTSARNKKLDKDLVADILTLSAIAAPSATADESDHWRAERRARTAQTTPAICCYFQIALASLTSEDFKMPKSNSSSSSANDEVKEELRSVAEAAANEFATPDKQEARAFLRERFLRVITGIVGKPAKFHLYENTSVTAEFRGCDIDFLELYVRNLTTPLGTIPEAVLRTNDVILLEMEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ41</accession>
    <name>A0A232FJ41_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000123">
        <property type="protein sequence ID" value="OXU30764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ41"/>
    <dbReference type="STRING" id="543379.A0A232FJ41"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="192" mass="21979" checksum="A6C1FBB9221E5ECF" modified="2017-10-25" version="1">MDRKSSQSESPTEKHVLTVNKWGRTRLQFTEFSYTWSVENFAFCRHRDPGYSITSPIFTAFNYSDKYQWQIILYPTGYDVDNKGYVSIQLVKVSSPDDPKHASIRLAIVDSQGREAFATEKFVLILKSLEYAVDIKHFAGQNDVFDGALEDGDLTIKCRILFDNGVSHFDSDTEADTAGFNLNQKMARMHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJK6</accession>
    <name>A0A232FJK6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000135">
        <property type="protein sequence ID" value="OXU30648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJK6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7067" checksum="C181A267ADA936BF" modified="2017-10-25" version="1">MDGQREKSSNTDTTSKIQLKERLTSLFEPGSSHHPAPMIQVEKQRHHPHQPAAPEEVRAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJY1</accession>
    <name>A0A232FJY1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000093">
        <property type="protein sequence ID" value="OXU31041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJY1"/>
    <dbReference type="STRING" id="543379.A0A232FJY1"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF98">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="10">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU31041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6761" checksum="E6D643AD555558EA" modified="2017-10-25" version="1">MSPLTPDTFFLYMLPPIILDAGYFMPNRLFFDHLGTILLFAVIGTIFNTLSIGKYKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKL3</accession>
    <name>A0A232FKL3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000070">
        <property type="protein sequence ID" value="OXU31296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKL3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="7076" checksum="3FC817A101FF924E" modified="2017-10-25" version="1">MYPTPDNDANGSRSNQYTPQVGGGGGGGGSDVGHIRHENKTNDDLTSSTSRSSGSRHRVSITAASDGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKL4</accession>
    <name>A0A232FKL4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000071">
        <property type="protein sequence ID" value="OXU31281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FKL4"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="867"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="924"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1690"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU31281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1724" mass="198578" checksum="AF1AD561BF0434CD" modified="2017-10-25" version="1">MRKFAYYWIVLIYIPCKIASADIGVAQIWPNLDLHQVTVLTNHLPEKGNSILRNILNNFPTLCIDPQKLRSASQVLRRSENSKLYIFLHDDLDIEFYKKRLYEVLNLIVQVAPVSTRPKCLAFFHSSTDNDDWALEEILIFAWHLKFLDFSIVKMRANGESVILSYNPFTRMFSASPLDSVVFPDKLHDMQGFGFLVPVAYRPPYIFINHDQATRKVKSIEGTSYFFLKTLSEKLNFTLITPILKKNITLDGIFDTYEATGARMSMVPVLVNSLSNRSFIVGRFFSDEKFVLIVPIISETKLRGPIQILIYLACFVVIMICFVLTAGILRFPLSQWQIIDVYQLLLGVALAKKQPSNFGQRIVYLSLVLVSMKYSGDTIAMLTGFSVEMGEKPFESFDEIVKSHVPVYMSELFLNQVYSRSDEVFNNLRMKPEIYGNFDDCIRNLVDRKSSICITTNIHGKFTVAEKNAFSKKRRNGGRVMKLAKVSLYPDKSTYFYESGSPFVERIERIERRTYESGLVYAWKTNQKFNRSVGEGTDEAEVKDLLLTEIVAVAGCGYGVACVVFVVELVVPFLWRREKVRQSYHQLTIFLNTTSFIHNPILSKALHEVPTIIIDLARFLITSDNPFSHLSAIREPRTTTMYMIFYTKTNIYQLPNLVNTIANLSPTSERPRCLLVQIDAGASDQLEIEHLLRYVWSAYKFLDFSILSSIHEPHPLICYYNPFTDLFHREYLDVNIHIFPDKLSNMHGTKIFVPTIHEPPFIFVQRSRRGKKIYGHSYFVYKEIAKRMNFTLEFVEDLDKLESANRTKVLFKLLADARVNMSMLPLSTSSNQQLSRKLVRSRETYQVSYSLLLPNIQKLRSENPGFLDAYILSLWFIILCFVMTAHVLRFTTISSSGSWRTINLVQVLLGSSSPKLPSQTAQRIVYFSLILLSLSYSTDMFSNLLNNKMKWRNCRFRSIEQVLQANISIMVSESFYNDIYLNNEDLIKQLGPRPRTFRNLMQCVCMIHETRKVGCVVTKESVMSIIRYDLGKWWRTTHRLQFLTFGEFQLFNDILTSVHVASSPMVYRLDRYVRLSFIHGIMSTWKPENEYDKMEKAVEVVADTGVTKSDFRARMEMILSRGKTMWICTACLIMVILSMSNERSVDSLKNDLFASLVNRIVSDLKTNNVVLFGSKSARPYSDAFCKRLMPKVPTISIDLSKMMIDKDNRSLSLPILRHPTFSTLYVVLVNRDETGDYLKNLESTLNTTVRVSPISARPNCLIVCYSEKTSSLDNWRNLLIYAWSLKFLDFTVAIVTPGESPILYDYNPFTKNFRKRLLAPRTDLFPYKLDNLHGYALKIPAIELQPYLYIKRNSEGEVVDLDGMSFKYCQIFRESLNFTTKFVTGMEDAVLHANFPPIFQRLGNAEIDMLSFPFNVRSIVYDFYDRLQLGRLFLNTNYVFIVPILPIVKIDIPLDVIYFVPVFALIVVVYEAAQRLLRFPKKYWEVCKIFQILLGVTVPRQSPNKMVEKIVYFSLIMLSMKYSIDALTKIMDIRLLKGEVAFKSLEEIAESALPIYTLDFIIEQTYGNNDEEVIQKLKKKTFPVADIFQCIYRMVDNKSCMCITPHSAGAYVAKMFINEDGTATTKVARPSLYDDTAAFAFERASPFARRFDELVQRIVESGISDSWDIAQKYTVKPSDFARRKPTKENIFLTQLYAVLSAGYALGCLSLMAELACKRYCACSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLE7</accession>
    <name>A0A232FLE7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000068">
        <property type="protein sequence ID" value="OXU31329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLE7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012805265" evidence="1">
        <location>
            <begin position="27"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="359" mass="40886" checksum="DC4F6C5303434A19" modified="2017-10-25" version="1">MSAVRFGFIICFAFVAAACLFHRIEACLERKKIHVFGEQEHVELLKEGVIHALQWKSKITPGLFYVMKFVAVVNVLREDYNHVDIIDVSENQLDGYVIDNLPILIQMILTGGEQCPCGKGPVLTPRVIECGDLIDCSFDKLIIGVYLTGHPEKDDVQILEVKYKTTKKPCHPLELKIQNFVIRVENNQNGYGEVLGLTDATDDSLEALRSHDYFSQLTFRSNKQYTDYQHMGSLRMGKGQRYLSWSNVTRGQFLIEFDPCSPPKYCSRCLKKLLIDFAYKAMFNGPLECPTNNGLSTIPDLVELRYPNDLTIQHCRLSEIMITVLPLAKNKIYAKVMKDFGGFSLNFDSIWTPCVKHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM90</accession>
    <name>A0A232FM90_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000047">
        <property type="protein sequence ID" value="OXU31568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM90"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="9026" checksum="9D55D6AED9763281" modified="2017-10-25" version="1">MERWQQRAEVDGTQNKGREQAKRSRREWKEAKEREEVNKKANKEELESELEKEKTERKKETKRILEKLEKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM99</accession>
    <name>A0A232FM99_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000047">
        <property type="protein sequence ID" value="OXU31578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM99"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8374" checksum="1E43C552BD4CF36C" modified="2017-10-25" version="1">MSRANQRAPMRSSLSARTGSQSVASKKRGPDEHERRVSARTSGEIREFSPDYRRSTSTFCESYVRPPLLVEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMG3</accession>
    <name>A0A232FMG3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMG3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7911" checksum="C1426D4FE0246A22" modified="2017-10-25" version="1">MVNLNLAVYLTYHWCSGIRHSRFDRLQQYFDFSLRTKPKRDQKPALKKLLHTAAAEWLHRKRARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMK0</accession>
    <name>A0A232FMK0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000038">
        <property type="protein sequence ID" value="OXU31678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMK0"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, DROSOPHILA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112:SF16">
        <property type="entry name" value="SIX-BANDED, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11588" checksum="C2A761B72FE8C7BB" modified="2017-10-25" version="1" fragment="single">MFPDFTPRLGLVATPSREYIIESRYALPRQARRRKEKKKENALVTARSIAKLSYPRVSRNIAAPSSTALGSLDQLKEYLTTAGTCKCGLDCPLRPEQVFNFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMS6</accession>
    <name>A0A232FMS6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_004339</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000011">
        <property type="protein sequence ID" value="OXU32041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FMS6"/>
    <dbReference type="OrthoDB" id="10031018at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012104656" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="16">
        <location>
            <begin position="17"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="970"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1000"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="217"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="18">
        <location>
            <begin position="311"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="17">
        <location>
            <begin position="558"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="726"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1056"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1170"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1479"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1536"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1073"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1541"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1557"/>
            <end position="1566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU32041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1595" mass="177727" checksum="7CAED956979E0261" modified="2017-10-25" version="1">MYKILVILTLAQCFLSASMCPARCNCRHIKPQAEWLRVVCKDNLEDVNDVDFNQVSIEMIHLDLSKNDISIIRVDTFKNLSNLKRLNLSVNKITLLDEGVFNGLPNLERLDLSKNLISSIDSHAFKRLSMLKRLKLNGNKLVTLKEGTFHGLPLRQLDVSGNPWNCDCNLFWFSYWIITNAIKLSPSPECDLPLNLKGKQVKKLKTLKEYECKWTTPAIEIVPDQNQVVFAGDTITLKCRAPSITNDKFARLNWLWNSNITTDVLDLGLYDNPQNSFSDVKIENRYLDDSGIVASSLSIDPVKEEHNGQWNCFLVSAYGNISRAINVIVISNSTRYCPLAVTRSNKGMYAWPRTVIGWKVELPCEGNSLPVGSFQLPPQASYECNSTGQWENLNTESCPYISATTKILESFSTVNLSLTKLSLPKGSLLETIKKLKNITGEGASLTDPVEVNFVTQILENYASYLVEEKELGSMLIDVVNILLNLPKSMLKAAEIHYGACTRLLKTIEHIVKVTPSNQLIQLHKTNMALEEYLVKADSFAGLTCTWYSNTADLYVKLLHCSMSNKTAIFNPSAGETQLEASIQLPASLFRNVKNSAGSHQLMVSMYADNKLFPKIKDDDNTDITTSIAGSKLIGQTVANLTEPVYVMLRAPLIHHASSKPVPVVWDSSLNNETGGWTSDGCHLLSNYINNLIIFHCDRLGYYGLLQDKSFLDIDGKTLVGAKFKYSNPAIYVGSFILLVCLICTTVTYVCCYASIAMPKKAKHCVVNTWVAIALLCFLYSSGIQQTENIEICQGVGIGLHYLSLCCLFWMTVSASNMYKRLSKSTMDPITDDDELREEPIRKPLLGLYLVGWGIALIICGISGAINMREYAGYSHCFLSSAPSLAALFVPAAILLVYLTILHMLIRCTIRNVDLNGQLSEGTQATENVDLELLEPNPNPGSDRVSLHSSQTVSSEVEDQEHSQMTQLKGLIVVMILYLIAWLCAAMTTANLFNIPYQETIFAVLYALSASSLGMFILLFYGIARSDVRAQWLRMRCWLKQKKNRCCRTRNVSDANPAIPTQPLVPLTAPPPLSNSQATQVTSDTNSLGSSRHTHKSHSSCNTSKLTSNVDPSTRVHVKPNLLMLHRQQYRSNNSVTTFNTESAPASVEMFYNPHQSGVARKFFKKQRRNMTKNSNLGPRKQGDGGATSDNGSCVSIPRRAVKLDNDIERSILGSSSKVNNTNIHVEMNPVNDAKNVNILSDSGGSVSEDRNLALRYVIGQESLGKNTRKVNNELSTTPTVVSRRKYQPMMNHATCTSPYESDATESKIEEEKQMRNVSQQCSLECSSEMESMTQIASERSEHNLSDISEMALSRSTDGIAGRRSSVDETISMERDQRIARHRYGARYDVLIFKEILFLINLQFSLERSYDMCNHHSGSLSSLPLADRSIASSRNKSSYRSSLNDATSLESSRAADDFDRILLGPGFINGSERRQQVLPLPFPTASVAPATSETKVTSEEDEDLEEDNVANAVIPLVEDEATLMGESLQLYDFGQREEREGHHHHHHHHKQHQGNSKECSREVRDDAPAGGRYPSDEDDDESAQPDRMNVKKETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMU8</accession>
    <name>A0A232FMU8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMU8"/>
    <dbReference type="OrthoDB" id="7699497at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="19851" checksum="09A5DD039409F8CC" modified="2017-10-25" version="1">MDESTSGPELKPVPSSRKLTLNTLSLEAANQHQHQLKSALLIPSRPPSSSSTSSTTFASTAKVTLSDGLRACHFNDNSLTGHIEMVRVFLSTRPLFDVIAITKTWLDDKIKYIPLLDNYSLYRHDRNSNGGGVALYIHYSLTATIISSSDDTWSGKPGGHAHLCRRRLSSTPCFFYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMV6</accession>
    <name>A0A232FMV6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000016">
        <property type="protein sequence ID" value="OXU31913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMV6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11678" checksum="DE87DAA5D3986B36" modified="2017-10-25" version="1">MLQLACTLLSRLDNSVSEGIGKPVRALARYSKSVFITLGIANRSSVSAINCKTIARSTETERFVRDHLRGVQRPSRHMLAEWEARAAGYVPDLYRRRQLNIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN68</accession>
    <name>A0A232FN68_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_002953</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000006">
        <property type="protein sequence ID" value="OXU32112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FN68"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000048">
        <property type="entry name" value="Brain chitinase and chia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF359">
        <property type="entry name" value="CHITINASE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850596" description="chitinase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="2700"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="136"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="475"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="561"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="1066"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="1167"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="1236"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="1340"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="1751"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="2198"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="2323"/>
            <end position="2692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="928"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1293"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2137"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2285"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="959"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2137"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2297"/>
            <end position="2306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU32112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2700" mass="302683" checksum="679F666B759C8C30" modified="2017-10-25" version="1">MGWPITALCSALLALSLFHTQAHHIPGHPDLRHVPPPDVPTFQRNAVESSPVNREYGSSGLPLRSAVEHVPEHYEGHRQPLRDAVEASPKHGERRQPLRDSVEHRLPPSFGGGFEHEAFWLEQLTPPAVRRIQNPPNVLCHLEAESVYREEPFILLPRSLPPHKCTHFVYSAASIDPQEFTVIPRDPEYDIVKGGYIAAAGLRRQDPALRVLISLASPDHGRLYREILSNANERLPPFVDSLLDFLAEHDFDGVEIDWENASAGPLKYLLRQLRAAFQERGYILLVALRPEQIADSELAELADLLVLRAWHSRRVAEVVQSPAPLGFVTSLVESLTRRGVPAAKIVVGMPFFGWSYKLAQKDDGESQHAVGFGINGPYTKHRGQLAYFEICEKLEDPWQFKRHEKNGSYLVLGDQWIGYDDPLSVKIKAAYVKSASLGGLSLYSLDLDDFQGICGDSWPLFNAAVQTLGIYDGPKERCPKTGLFSDPDNCSGFLSCFNGYLHRGHCGMGRFYDPIRGRCVSASPEVCDPGHSDKFSYANWSLERLRQRQRLEKLELLEDGPRVVCYVTSWAMYRKGDGKFVPEHLDARLCTDVVYAFAGLNPETLTVHSFDPWADIENNLYQRVTSISGTRVLLALGGWTDSAGDKYSRLVNSASARRKFVASAVHFLRKHNFQGLSLEWNYPGCWQSDCRRGPETDRPNFTRLLAELRKEFDAQEPPLTLAVAISGYKEVIDKAYDIQEISKLVDFMTVMSYDYHGAWESTTSHLAPLFAIPGDSSPYYNLNFTLNYLVSLGADRSKIIADIPIYGQSYRLTSADKNGLGDPVAGPGAAGEYTRQPGMLAYYEICDRIEKENWELGPGPSAHYKDQFVSFDSPKSILYKGQYILNHGFGGAAAWTVDLDDFTNRCCQEPFPLLRTINRALGRLLTPAPSHKDCKKPEEPVTPVAPTLTTHADANDGKPVPTRPITTPSTRPTTWPTWTEKPTTPWNQGTSTTWSWTSSSTTTTTTRRPIITPGVTSTKRPSTQRPTTQRPTTQRPTTQRPTTQRPTTQRPTTHRPTVPSTGSLSGSSCSSGEHQPDPANCGTYYRCVLGEFKREFCAPGLHWDTNRHLCDWPTAAKCKKMSTTTTTRRPTYATVPTTEFTTPNAGIPSPSTTISTVTQRPDGSKPGKDCEHGQYYAYPNSCTHFLVCVNGKLVRQQCGPGLNWNEAKNMCDWAFKNPCNDTKRNMPAKITQKDEAQSCTAGEYQSVPGDCESYYACLWGKFEEFQCAPGLHFNAESQICDWPARAKCQATAPSGGAPAVDNGSGFTTQKPWQPPPAQSTTPLPSAEIDPDKVSPLSGHFKVVCYFTNWAWYRRGVGRYLPEHIDHTLCTHIVYGFAVLDYSNLIIKAHDSWADFDNRFYERVVAYKKRGLKVSLALGGWNDSAGDKYSRLVNNPAARQKFVEHALQFVEKYGFDGLDLDWEYPVCWQTDCKKGPDSDKEGFSNLVRELSQVFRPRGLLLSTAVSPSKKIIDAGYDVPVLAKYFDWIAVMTYDYHGQWDKRTGHVAPMYYHSDDEFYYFNANYTINYWISKGAPPRTLVMGMPLYGQAFSLNDPSRGTGLNSPASAGTAGEFTKAAGFLAYYEICDRIHNKGWQVVQDPERRMGPYAYKGNQWVSFDDADMIRQKAQYVRDMGLGGGMVWALDLDDFRGRCGEGQHPLMHTLQQVLADPPNSHDRPINPPRYGQKLEWRMADSPSRNEVSANLKQSEDDEYKVVCYFTNWAWYRQGEGKFLPEDIDADLCSHIIYGFAVLDGSSHTIKTHDSWADVDNKFYERVVAYKAKGKKVLVAIGGWNDSAGDKYSKLVNNSANRRKFITHVIQFIEKYGFDGLDLDWEYPVCWQVDCNKGPKSDKEGFTALVRELSAEFKPRGLLLSSAVSPNKRVIAEGYDVPVIAEHLDWIAVMTYDYHGQWDKKTGHNAPFYARPDDWDTTFNANFSIHYWMERGAPAKKLVMGVPLYGQSFSLAERNDNALNAPTYGGGEAGDATRARGFLSYYEICQRTLTRGWTVVQDPQRRIGPYAYKGDQWVSFDDAEQVRRKSEFIKELGLGGGMVWALDLDDFKNYCGCEPSPLLRTMNRVLRNYPAGPLCTVSCKSLEPSASTVTENEPATIKPTTERPTYPPVSQPSRPTTTDIPIEVATEDEDAVEVEAGGSAPSHGQPQGDCHGKLFIAHKDDCRKYYLCNFGMLTELTCPNGLVWNEDHCDWPENTNCKGKPFGGGSGSQQFVRLKMNYPNGEFFFDSTVRPTTTTSAVHPGQWQEPTRPTTSTTTEDYSIQEQPEELSIGGRKMVCYFTNWAWYRQGVGKFLPEDIDPNLCTHIVYGFAVLDYERLVIKMHDSWADIDNDFYGRVTKLRKRGIRVLIGIGGWNDSAGDKYSRLVNNPEARRRFVQDILQFIEKHGFSGLDLDWEYPVCWQVDCSKGPASDKAAFSALVSELSAAFKPRGLLLSAAVSPSKQVIDAGYDVPLLGHHLDWIAVMTYDYHGQWDKKTGHVAPLYYYPGDDYDYFNANFTMRYWIEKGAPSRKLVMGVPLYGQSFTLAQGLQHGLNVPAPGPGQAGEFTRAAGFLAFYEICSKVKNNGWAVVKDPEGRIGPYATRGDQWVGYDDVSDVARKADFIRDLDLGGGMIWALDLDDFRNTCNCGKYPLLTALTNGLKGDVNQRQDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNP7</accession>
    <name>A0A232FNP7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNP7"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU32139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="111" mass="13324" checksum="93E9B31C84EE5AE4" modified="2017-10-25" version="1">MKTDSVITGLQYKDWPSANDIYTTVDQNDSSSMRHPCPRCYRTYKHRSHMIRHFRYECGTPQRFECPYCKIHLRQRTHAWTHIRTFHPGREMYCVDIATNAKLTRRDSKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-05-29" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDD8</accession>
    <name>A0A232EDD8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006683">
        <property type="protein sequence ID" value="OXU16369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDD8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="8329" checksum="5668E47E6D8F2F9E" modified="2017-10-25" version="1">MPLNTGYFLTISTGLENSVTRHFFDVGTWFYMVLNMYNKKKKSCGRVLRHLFFFRFLQPENGIFPVEFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDR3</accession>
    <name>A0A232EDR3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="11">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_009113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01005965">
        <property type="protein sequence ID" value="OXU16506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDR3"/>
    <dbReference type="STRING" id="543379.A0A232EDR3"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU16506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="26484" checksum="A3770E9BA6A19529" modified="2017-10-25" version="1">MDRIKSRFIIYNLRLVIKRLFPIIDLLNIHIPCVHSRSLYHGDYPKPEFDELRKDSTKNPCVKNSESADARKVAAYLPTLVAGVAGLYASKAIIHQHLMTMAPSRDVLAAAKTEVNIANIPENKVQIIKWQGRPVFIYHRSQELIDQERAMNIAELRDPEEDSARSKRPEWMVLIGICTHLGCVPIPNAGVVPGGFFCPCHGSHFDTAGRVRKGPAPKNLVVPPYEFTDDQNLLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDX1</accession>
    <name>A0A232EDX1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005809">
        <property type="protein sequence ID" value="OXU16550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDX1"/>
    <dbReference type="OrthoDB" id="6408700at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7514" checksum="179E6FB764AB652D" modified="2017-10-25" version="1">MAYQLRQHTLLETGSNEWFDPLRDKTAKSVASGLEQILQRNDSRQPIYFQTDKSKEFIGREVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE06</accession>
    <name>A0A232EE06_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005792">
        <property type="protein sequence ID" value="OXU16564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="359" mass="40165" checksum="BE7E5967E1A13E4E" modified="2017-10-25" version="1">MLYLSGSGLPPILFGLAWCCFRDVRRRNCYRNMCAEFAKICLVGQPAFSEQRLLCTQEPDFFLNSKMRDEAALVGSPEDLFKRMGVPFRTGAPDLYSLAGTRAFFDQCVRDVASGCLSPFREVRTRNCYRNMYAECAKICLAGQPAFSEQRSLSHRCAGSLLVGWYARLLRPSPVYWQNTTPASVGITSRLCELPWHHHPARNPEALAAFGAVCLTDLHVEDNYFDSANVIRFGEVGSGKLPWHHHPARNPEALAAIGVNEPSAYVSGRYALTDLHVEDNYLDSANMIRFGEVGSGKVWLLVYPRSXSPVYWQNTTPASVGITSRLCELPWHHHPARNPEALAAFGVNEPSVYVSRRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE82</accession>
    <name>A0A232EE82_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005550">
        <property type="protein sequence ID" value="OXU16638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE82"/>
    <dbReference type="OrthoDB" id="7699118at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12824" checksum="612E16FAE0BAA615" modified="2017-10-25" version="1">MNHFIKKKTVKNFNASSLLRCQSEIRQQFERARYISNVWRNAPTELKPTNCGWIQQGSTYEFKWFEGPQLPVNDVIREEENEESGAEDDESKIDYASDEDEHEQSDCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF61</accession>
    <name>A0A232EF61_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005104">
        <property type="protein sequence ID" value="OXU16991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF61"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="465" mass="53065" checksum="1CD0EC5C631C6EDB" modified="2017-10-25" version="1">MTTAKYKRVEFSDHSMSVVPRFWLHNHDKCCYWPPYKGQLKVDRAVIEMENPDKKKWSNYNVIKVRGQASDYQEALDNLKLLVTTSDADDIIKDASAYKSTRQKRARKKSESSSEDSEKNTPEKRPVKRFKTIKENKTSDKQSKDHNSSDTFSEKNDSEIETPPQLNVNFQSQNDDGKEPSPLNIRSTSTILKDIANGIASRSNSPEITNPTNTAGVENETPKGRRYNEKEKDAVLSIGKDAVVANIEDRRTSKQTQESDGDQTPIKSRLPPRSSRVLTRDEEIENRYAKSISQIETKAGEDEGALNIAYFKEIIYLLSKQSTEIEEIKRQRFDSSKKCRSGKTKKFDWSTVLPFKDAGTFEAYSKKIEKDSEIEESLIELLKCLGGRDDRIKTNTIMEKIMTDSLGSNEKNKKAKSKRFVFKFSGTILQVTTETYTETDARGQIGSWLAGRKAKLDREKEKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG25</accession>
    <name>A0A232EG25_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004881">
        <property type="protein sequence ID" value="OXU17301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG25"/>
    <dbReference type="STRING" id="543379.A0A232EG25"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 5" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU17301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="816" mass="92336" checksum="6BE5E04D2887105C" modified="2017-10-25" version="1" fragment="single">FNSARIKMGDSDLNELLRRAEQMAADVEGNGELPQVERNLRQILDGSNEIWSQMTQTGTQDNQVQAHLLLGSKGIDLSQIAQKLNSLSTRRTFEPLDPIADTDIVSYLRNEKENAILSIIEQVHRDTFELNRVQQLEHTLGEWKQMRFEIMNAMTAPSGELVDLRGTPQRTKLAGSMTSLSQVESAYAKELQNYNEHVLKGVTRPSLFTSFAKAAESFNDKKVLDMWQMVKCMVDIPPTPAGDQIKSRNSNIVEMKIVCQARKYLESRYKEFMNSVVSENLAQARRGGIPGTLPLVKSFVGIKIQNTRDLEEVMVEDRPLWPLVYYCMRSGDLKAALQCLDQCGAGFQEFRSALEEAIEYPLHHPSSRAESTLKLHYRKHVRSATDPYKKAAYCALVPCEPDDLHTEVMSAADDYLWLKLCQVREQPDPENKLTLDHLQTTILEVYGESYYRAHEQPFLYFSMLFLTGQFEAAIEFLARGAGGRHLAHAVHLAAAMHEHSLLAVSQSVLAPLISVDPADKLPAKRLNFARLILLYVKRFESSDPKETLQYLFLLRCMKDPYDRNMFAASVAELVVDATPANRTVLVGKLNKDRRLPGVLDQFQINTEDVINISAETLYRKGVLEDAVMMYDLAGNHEKVLSLMCVLLAQIVSQKSNPGSLRSRLQATASEISARYQGLPIQAPAESVAAFYTLRDLMVFFDQYHNDQYQNALRTIADSKLLPLHVKEVDERVTALRRVSPEVTGTLADVLLATMTILYKQYQKLRSTEPGDEIAREQQLKDLREQARALTSFAGTLPYRMPNETNSRLVQMEILMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGF5</accession>
    <name>A0A232EGF5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004794">
        <property type="protein sequence ID" value="OXU17402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGF5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="141" mass="15838" checksum="362C46A129030C32" modified="2017-10-25" version="1">MFQIKKGAFMRAKRYTAIEACDAKRGCPMGRGPLMAGRMEGPGREKPRGPQLKRDRTRVRRWRAVAPVVSGGRRAALTRERDRGSSNEILSTQLRPPPRSPPSRRRREKRPCRGGRSGPSSAENSNRTTLRSQLSSSVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGX1</accession>
    <name>A0A232EGX1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004662">
        <property type="protein sequence ID" value="OXU17588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGX1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13950" checksum="BD4D601A4AAC2FC1" modified="2017-10-25" version="1">MRIMSTKYLQPADPVNWKEGDLNQVNIPIQKIYNLLINKAHGISHIIKIVWSAIELKNISIDFTKIRYAMHYIDKEKGLANCAYVKNFSNHQTVLPFHRAVKQFIYMTTNKHKKLIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGY1</accession>
    <name>A0A232EGY1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004652">
        <property type="protein sequence ID" value="OXU17601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGY1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="40" mass="4614" checksum="7AC79BCC42F3B0C8" modified="2017-10-25" version="1">MCNVNQKSFVQKGHLNVHVKTHENVKSYVCSMCQKTFTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHJ7</accession>
    <name>A0A232EHJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002311</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01004496">
        <property type="protein sequence ID" value="OXU17813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EHJ7"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325588" description="phospholipase A1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="58"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="363"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="718"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="1074"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU17813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1349" mass="150710" checksum="B29523ED47B48324" modified="2017-10-25" version="1">MRLPALIVFFFALRMTCSRCQEQFSAFSCALGRDEVSPRNQRLANKIYNMTHQGVVRSAAGYVSFHLYTKENPLGEELYLGANKALEKSSFDPNRPTKFITHGYVSSRDSESCTMPRNAFLRNGDYNVIVVDWWPMQSIWSTVPLDYWTVSGYVEEVGSYVAEMINFLENHGMNLETTTLIGHSLGAHVMGIAGYQARSKVNYIVGLDPALPGSFDSRHPTERLSPDDATTVEVIHTNSDNCGMTYQVGHYDFYPNGGRKQPGCNSNRCSHSRVYELYTESIDAGNNGFFGRRCSDISAVRDGSCDGDVAIMGGSMRKLDSMYFATIMRSFAAVLVILQVLICSGYPATDSGISCALGYYDNDNPIDDEQQLTDLFFKKTNDTSIESKVEFRLYTREHPNGVQIIFRDESSLKNNGFEANRPTRIITHGFNGRGTDRACIGPKDAFLSAEDYNIIIIDWYVYQLGGGSIPNYLKVIKQVKEVGVFVSEMINFLEEHGMNPNTTALIGHSLGAHVVGIASYHAKTKVNHVIGLDPAEPQFKNKEPSERISDKDAVHVEIIHTNGGHCGAAAVLGHYDFYVNGGEKQPGCARNSCSHSRVYEYYIESIQRVNNFYGRRCMNSKVIEKENCNGEIGLMGGLNRNTILPGVYFIETNKESPFAKETMIMRSLNYKIVFNLLLILKTINGTPDGMVACAWGSHENNYIISENDGALDRNVTYAVKEDDVKFLLYKLEYPYPYKIFINEESRLISGNFDITKPTKFIIHGFGSSDKSNSCVIPRDAFLKSGDFNIIVVDWNRAQHWGVNHIIPETYPAVVKKLKDVARYITQMIQFLENYGMDLSTTTIIGHSLGAHLAGIASYNLKNKVDRIVGLDPAGPYFENKGPGERLSKEHAKQVEVIHTDTQECGLKDQIGHYDFYPNRGTVQPGCEKHKCSHSRSYRFFAESVISPNAFYARRCSDWKSLMDANCDGELVTMGGLERTPIKEGIYYLQTNSDSPYGMGRPSVHMASLLLVLASNVFAMPPASKLQRFHSMVTEDDRKLFNSTEGLWFLDDEGRLVQATLDMPITRGSLFVSMDTHVKFELFTKDLHAPIYIDDVKTLERLNFDPTRETKFITHGWINSGKSKACTLIRDAYLKQDDYNVIVVDWSKITIRPYGWAATHVLEVGKHVAKMIDFLADQGINLKTVTLTGHSLGAHVMGLAGYYAKSKVNYVVGLDPALPLFRLAGPGTRISMEDATHVEIIHTNGGLLGYLSAIGKADFYPNGGKRQIGCLIDLGGACSHARSYEYFAESITTNSGFYGMKCKNYSSYLKGKCEEVVGLMGGAKPYLPYTGTYYLHTQRKNPYAKGKTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI93</accession>
    <name>A0A232EI93_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004298">
        <property type="protein sequence ID" value="OXU18087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI93"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="309" mass="33537" checksum="0B21F41549309EEC" modified="2017-10-25" version="1">MRSTATVAMGFGGVFFSTKGAFPRGSSNGTLRISLKMTLGLRLLDRMRGLNNNNFESPSLFPIVCIHLSLTPPQKYSPFSTKSTSTPNWAFSSCSGTLTKTRLPYIFKFSTLGLIPKNISYEGRYKNCSSSGIPVLSMIQMNSCPVARLMSHLWVDLVLCLGHDLCSFNLCCSLFDDLVDLDWIEHLVLGCSAALSGKALIKYLIFSVASSLPPASLNSFTVFSNSAKKSLGVRWRRRVIEDQRCPGSLGAVSHRFVGDNFPAGSFLFRGEMQALLRCTACAACLAAILRLMICSCVLGIAAARVGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIG3</accession>
    <name>A0A232EIG3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004255">
        <property type="protein sequence ID" value="OXU18143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIG3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7476" checksum="0CD7855451B69905" modified="2017-10-25" version="1">MTAFEENNALENLLADITSDEDDITEYTSNENVEHTSSDEGEEEEEAERETQVRRRIQRKRGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIS6</accession>
    <name>A0A232EIS6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004165">
        <property type="protein sequence ID" value="OXU18256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIS6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10746" checksum="2B67088CDF2E308A" modified="2017-10-25" version="1">MLVNLTRANFKKSQKSRSTLDVVYEVSHQVTYPQSDAELLAVKEEKESFTSRFQIFFSTLNQGIYGVEDLATRKVKESHGETRIIATEKRSCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJI8</accession>
    <name>A0A232EJI8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003989">
        <property type="protein sequence ID" value="OXU18529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJI8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="46" mass="5414" checksum="A36C6EC5E01A7A1C" modified="2017-10-25" version="1" fragment="single">YIYIYTRITAHSQLAPVNTSVYVVYTTKKADIIFFFPLKLFPNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELM7</accession>
    <name>A0A232ELM7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003545">
        <property type="protein sequence ID" value="OXU19228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELM7"/>
    <dbReference type="OrthoDB" id="7549643at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="221" mass="25520" checksum="595464F552221E07" modified="2017-10-25" version="1">MYKNITLDENSWTLLKDQFDAITAYLNNSYSFYHEFGHPVKIYLTNHDLNFSTAYGIKSITIDERPKNKQPSEEDEEGEIAQPVSKKMKTSTPPGIVMQQPTFEGLSLHSSLVDQRLDALKTLVGKVNRTYDYVLEYLKIALEAQEPQNIKNILIDFKEFKQFYSRHNIAIEGFVLDKMVDDNNDKFKEQYLRIVLSEILVSGLPFIAKDVPSAYTMYILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-11-27" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMB5</accession>
    <name>A0A232EMB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_013316</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003383">
        <property type="protein sequence ID" value="OXU19504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMB5"/>
    <dbReference type="STRING" id="543379.A0A232EMB5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371196" description="Peptidase M13 C-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="48"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="445"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="75522" checksum="9E13652C14819226" modified="2017-10-25" version="1">MYFKKYFKCRTCFYILIVIASLTESIDSNNSNSTAVCKSPGCRAAVISNLKQALSENIDPNEPRTFKLTKNYYNACMDLYVKTINNKGLQPLLDIINDLGRWPMVVGNTWNESKFDWMRTLYKLRQYGYLDYILGIFVGVNENNKSKPIIEVRPEILTSGWSHPRLQSYHKYMFDVATLLGADPQIADWQVYETINFEAKLAYYADDSLVNEFVGSIANVAFNVPQIPWLDLINNLTFPVANFTMTDQVRIFKQVYLDDLPLISNISKRTVANYLIWRVIDDSAPYISNDIRKLYDNFNDINEPRHKHCLNLLMDDDVGIPVGVDAIYVKKYSNNDTRDDVQNIIQYIKGQMEFFINQLTWLDNQTRNGALEKVHRMENVVAYPDDFYDYTKMDMFSSKLDIDPNNHLQNFLNIQLFNYEKHIATINGFTGDFSFDTETAYTDVNAVYGPDRNRFKISAAMLQSPLYRADWPNYMKYGIVGDVIGHEMMHAFDNGSFRFDATGNLTQWYTNQSALEYENKMQCFVQHYEKYHIKRLNLTVNGSRTLNENLADYGGVVMGYTGYKKWIEKNGKELPLPGLNYTPEQIFWIMAASQDCSKSRRSHKEYMLLNEEHTLEKFRVFGMVSNSADFAKDFNCPVGSRMNPKKKCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENH3</accession>
    <name>A0A232ENH3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003162">
        <property type="protein sequence ID" value="OXU19888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENH3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="49" mass="5910" checksum="2A726135F1615334" modified="2017-10-25" version="1">MAQHSWNFPAHTRVYLCIYKRERKFSSSSPRVGRCLAYQRKEARSPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENU7</accession>
    <name>A0A232ENU7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleavage stimulation factor subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CF-1 77 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cleavage stimulation factor 77 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_002303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003069">
        <property type="protein sequence ID" value="OXU20030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENU7"/>
    <dbReference type="STRING" id="543379.A0A232ENU7"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000002">
        <property type="entry name" value="Cleavage stimulation factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:002655">
        <property type="entry name" value="Cleavage stimulation factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="13">
        <location>
            <begin position="32"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="696"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU20030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="731" mass="84293" checksum="3F10E0DA1D9B1DA4" modified="2017-10-25" version="1">MPIFCLNGHSFCGCPQSYGNFKSSLKDWGNEKLQRAQKTIEETPYDLEAWSLLIREAQNRPIIEVRPVFEKLVTVFPSAGRYWKIYIEQEMKMRNFEKVEKLFQRCLMKILNIELWKLYLSYVKETKASLATYKEKMAQAYDFALDKIGMDIHSYSIWNDYVVFLKSVEAVGSYAENQRISAVRKVYQRGVVNPMINMEQLWKDYMAFEQNINPIIAEKMAIERSRDYMNARRVAKELEAVTRGLNRSAPSVPPTGHPEEIKQVELWKKYIAWERSNPLRTEDTSLVARRVMFAIEQCLLCLGHHPAVWHQAAHFLELSSKILTEKGDVNAAKNLSDEAATMFERATNTLLSKNMLLYFAHADFEEGRVKYERVHQIYQKFVDITDIDPTLAYVQYMKFARRAEGIKSARTVFKKAREDQRCRHHVYVAAALMEYYCTKDKNIAFRIFELGLKKFADNPDYILCYIDYLSHLNEDNNTRVLFERVLSSGSLEPEKSVDIWNRFLEFESNIGDLASIVKVEKRRSAVLEKIKEFEGKETAQLVDRYKFLDLYPCTPMELRSIGYMEVSSVNRNTNGPLPRVADTEEVIAALPRPDLSQMIPFKPKVNPLPGEHPVPGGSFPLPPAAAQLCTMLPPPGCFRGPFVSVELLMDVFSRIQLPDHAPLPIADNGCDTKLFDLAKSVHWIVDETADGKSIVNNRKRTRLGGDDSEEEDLPPPPANDIYRQRQQKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENV0</accession>
    <name>A0A232ENV0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003082">
        <property type="protein sequence ID" value="OXU20011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENV0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="45" mass="5296" checksum="22E20112E5DB46C2" modified="2017-10-25" version="1" fragment="single">IKWCGSATKASLRSRRSRGARDTIYFYISVRIFHETEKNAYCYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENZ0</accession>
    <name>A0A232ENZ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003039">
        <property type="protein sequence ID" value="OXU20075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENZ0"/>
    <dbReference type="OrthoDB" id="5953030at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="197" mass="22585" checksum="89068B28584E6608" modified="2017-10-25" version="1">MGSNPEPRDASHGARPLCYRCDTSLALQTYASVTLDNFGPWLEARRVPHLPASLPHITSAPETSKSLSFDLRKSLVQSLVLPFFDYACLVYHDLTGELNLRLQRAQNVCNRFVYGNILWTDHVTAYRQKLDWLPVKGRREYFLDTLTFSLLQTNRPVYLISNLILTTNRGVRRFTRHGVLTFFIRHFPAAYPISGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP58</accession>
    <name>A0A232EP58_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002988">
        <property type="protein sequence ID" value="OXU20169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP58"/>
    <dbReference type="STRING" id="543379.A0A232EP58"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000012">
        <property type="entry name" value="Rh type C glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601811" description="Ammonium transporter AmtB-like domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="55"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU20169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="480" mass="51808" checksum="7469DA4147BEFEBB" modified="2017-10-25" version="1">MLLLLIQIIVIVLMGTLMTYGPEARPVPRNRSVSAYSPTNSWLADDKKDDDPPPLYPMYQDVHVMIWIGFGFLMTFLRRYGQSALGLTFLVGAILVQVAMLCEGVFNIGKNGKAHLSLKSLLSADVAVAAPLISMGALLGKTTYMQLIVMGIIELVVYTANKYIGEHHFVVVDAGDSMYVHAFGAYFGLAVSFVFGMKEKPKEHSLEGSSYESDIFAMIGTIFLWLFWPSFNSAALKGDEQRRAIINTLLSIAASCVISFAVSAFVSKQSKFNMVHVQNSTLAGGVAIGTAAGMMCEPFGALAIGSAAGAISVLGYKYLTPLIQKRLRIHDTCGVHNLHGMPAVLAGLFGALLAGLANEADYNYSLYEIFPGRIPGLGPNLTEINENYRLSLKPGPNRSAGQQAAYQLLALAVTLGVAIVSGLITGLILRMSICGTITEDQKFDDSVNWEFEDENAVHDISSASKDGNDRTAEQLSMGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP86</accession>
    <name>A0A232EP86_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003004">
        <property type="protein sequence ID" value="OXU20142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP86"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="26" mass="2900" checksum="90BEB9224E81B0FD" modified="2017-10-25" version="1">MCPRERLPPIDSLAWQSQIGPLASPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPF9</accession>
    <name>A0A232EPF9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002936">
        <property type="protein sequence ID" value="OXU20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPF9"/>
    <dbReference type="OrthoDB" id="250548at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019351">
        <property type="entry name" value="DUF2039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876:SF5">
        <property type="entry name" value="CHROMOSOME 9 OPEN READING FRAME 85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22876">
        <property type="entry name" value="ZGC:101016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10217">
        <property type="entry name" value="DUF2039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="280" mass="32997" checksum="A1341CA7B247CD46" modified="2017-10-25" version="1">MLVDINTHTQHNLKPDTLHVFQLGLFPLGLFSIVICLLALSNNQLYIFRRTKYNRGLFQKTFIQVKKSEMSTQKGNTHRTRPQKHRNQFAFKNTLHDTSHKTKTINSLQIANVCERCKKILEWKIKYKKYKPLKAPGICNKCDQKTVKHAYHTMCGPCARERDVCPKCGLQNELVAPQPTKEEQLKLDNEMQSMLKTLPERKRRTFIRYMNKNTKKKRKQRRENEEYVDSDSETDDNDEERKECTRDDLINKLKSLMIDEHKDDDGFDSDLSDDELDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQV8</accession>
    <name>A0A232EQV8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002705">
        <property type="protein sequence ID" value="OXU20740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQV8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24431" checksum="BB669984FE362C19" modified="2017-10-25" version="1">MIAKRLNPRATYPTKGVAPCGTWYNSDTVRPRIKNLGKTVREWSLKFSGDKGVSIEEFLEQVEENRRLDNIPDEEFLDSMVPMFEKPVLFWYRTLRSSWQTYQDIKRADLNNYSRTKRNIRIWWSKLIYAHKDQVNLVIDNMLPKLKKKMKIYRGRLTNTQELLDKAQEAEIETNRQVLMAIKFSAGIVAGQGTQSSPAQNVQKNCQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERQ5</accession>
    <name>A0A232ERQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002577">
        <property type="protein sequence ID" value="OXU21011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERQ5"/>
    <dbReference type="STRING" id="543379.A0A232ERQ5"/>
    <dbReference type="OrthoDB" id="7699712at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53219" checksum="84B4544466C4D40F" modified="2017-10-25" version="1">MTIVFPIKKRQKVDKIINLKSNQKMKIREFAEIIGFLVSCCTAVEYGFLYTKASGRAKYLALEANKQNYETKMTITDTIVDELNLSAFCNGERANGHWTNEESCYFINYLELLAAFFGLKIFAKNHRNCSKRQKIDKIVNLKSNQKIKIREFAEIIGFLVSCCTAVEYGFLYTKASERAKYLVLEVNKQNYETKMTITDTIVDETDAGTKLPWWPESCPTSAKFKRSSRASNTDISRIINRFFDFCIKNKLNPFDKSIKDILLFLTSIYDTGAAHSSLNCYRSAIALLVRPEIGEDERMKRFFKGLTKIRPSKPKYESTIQISLASLTDSSIYNTGAAHSSLNCYHSAIALLVGPEIGEDERMKRFFKSLTKIRPSKPKYESTWDPKIVLDHFSKSPKNEDLSLKLLSTKLISLLALITGHRLQTISLIKIDNIVTKNDLIEIKIPDRIKTSGPNKNHPQPLYKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERV1</accession>
    <name>A0A232ERV1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002553">
        <property type="protein sequence ID" value="OXU21067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERV1"/>
    <dbReference type="SMR" id="A0A232ERV1"/>
    <dbReference type="STRING" id="543379.A0A232ERV1"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000041">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000002">
        <property type="entry name" value="DCN1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF12">
        <property type="entry name" value="DEFECTIVE IN CULLIN NEDDYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU21067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="260" mass="30301" checksum="0F3955596FDCD541" modified="2017-10-25" version="1">MPRTKRRAPSSTNNHSSSDNPPSNPEDMPRHPSKRLRQTTSSRRHTKAEDGTNSTFSQKRCISWFREYTTADDPDTLGPEGMEKFCEDIGVEPENVVMLVLAYKMNARQMGFFTMAEWLKGLSELHCDTIAKVQQKLDYLRNLLNDQNVFKGIYKYAYDFARDKDQRSMDMETARVMLQLLLGRNWPLFSQFAKFLDQSKYKVINKDQWCNILEFSRTISDDLSNYDLDGAWPVMLDEFVEWLKAQQQGESTSQMDTRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESF2</accession>
    <name>A0A232ESF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002428">
        <property type="protein sequence ID" value="OXU21290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESF2"/>
    <dbReference type="STRING" id="543379.A0A232ESF2"/>
    <dbReference type="OrthoDB" id="7698403at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="565"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="709" mass="81323" checksum="A21FEDC1EDFCC4BE" modified="2017-10-25" version="1">MREQDTVGDFYDEINVLLSSAKNALKEEKGEEFKNEMMVPLETLAVDIFIKGLPANLAERVDCSKPNDLREAYEEAVRLEIKMDTIIIPDSRPYRGRNRYYNNQDKTIIMDRNMEILIVIMDDTDYVGYVNDRTYNGQQLNESQNYRPQNNYLGNNYRERGYQNNYVNQGGRGDYYLGNNNTLIGRLEIATEIEEASKYSNETGRYYDAPPYPDRRNDTNWCNNHQQHNDQAQREARHDPRMPKPRLLEPESKASNAESEHKSSSEPTDSRKLRSTELSTTTSSIQREQKCEFNEPRQQSTVGTSGGNLVEAREISRMWATNYKGPENVNWEDNKATAVRIRIPVGTIKPWVEFMIDYGATVNLIKASVLDDDMPDDRELGGIMNQTVKTYASIYLHMKGTPVKFQIVSDDFPIPFDGMLGRNYLKKEEAVISYYKNALMISGDVMHPIPFIGHEEEHDTKKLRKGYKCKQANEILKVHQHKHAQESVATWQRRVAVRNLALVVAVSVSVSAVKMSNFRAKNGRFAKKNVDDKLKKAVLAMLEARKKRSRNSKKEDCSDSTIFEGCRVVNIKEFARNLKCKNCKQLLDLEHSLDENRSGLFSAFVIIFDNCQLRNDVSTSGKYNNEGKNYSNVNTTSVLGTIHSGQGFTSLQKLFSCMDIPMMTEKVYKKYEKEVGYAIEEADQESCRRATQEERSSVIENAEKLCDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESM1</accession>
    <name>A0A232ESM1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002398">
        <property type="protein sequence ID" value="OXU21354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESM1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11146" checksum="0DF9EEA8B726E26D" modified="2017-10-25" version="1">MPGEFFVTSSAKANQATFLTTLKELFSNIRPVAASRHSTPHPFYYKDLATSTHGTEKANSTDQLKPAYMEISDAEGTQPTQPTQPAQPATQEHTDGTPPPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESV8</accession>
    <name>A0A232ESV8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002369">
        <property type="protein sequence ID" value="OXU21443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESV8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12403" checksum="3A6DEF17832436A1" modified="2017-10-25" version="1" fragment="single">PGQRIAALDQFYLVQQLERDRQLLDVSRSVIEASQTQNITKQFVISRLKGKARKSLESNTFQTLAELKKHLRDCFAPSRSYGYYLNEIQTASMRKGENVRRFFWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETA5</accession>
    <name>A0A232ETA5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002300">
        <property type="protein sequence ID" value="OXU21589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETA5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="14598" checksum="C0E58911CF831592" modified="2017-10-25" version="1">MRAMNLTPEAMLKVDSMLLNQASYQVVDWKANTPATSPPPRGQRSKTPDHLVTTSPLNHRLLSRQPFGPSPDNCQQIFRLGNHPRETIAFGNHTFSQHGKVSLARVNFPDHGKTSGFPGTARHISWRRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETY0</accession>
    <name>A0A232ETY0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002228">
        <property type="protein sequence ID" value="OXU21767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETY0"/>
    <dbReference type="OrthoDB" id="10452666at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="23404" checksum="B09C7E4BF198FF14" modified="2017-10-25" version="1">MEIQLQHTIMNPVERIIIRHYAANTFMFDHNDERYYTLTEKDNVLSKIKRVILKEQAINMSKKDIKSKYKYLRDNFVKTDKLIEAKKDITYLQKCLYQRMYFIKPFLSPNPKTKSTYEVKRNIQSSETCSEAFIKELEAYRINTQKLMPNKYVNMLNKKIQEKSDTRVQRLKFCIILKSIRAFKYLESHVEHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU61</accession>
    <name>A0A232EU61_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MENTAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002182">
        <property type="protein sequence ID" value="OXU21857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU61"/>
    <dbReference type="STRING" id="543379.A0A232EU61"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF4">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51439">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="6">
        <location>
            <begin position="154"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="367" mass="42234" checksum="41C69C9A9F6D027B" modified="2017-10-25" version="1">MFGLPRGLPSQLIFACEFPDFITVIKARMPRHQMRFLGLPGDIFQNMTQVYKGCVRWGMHVLRGNFALPIRSLSQMTFCPNRVRGWRGNFSVLDYIKKISIFKEDRRNLKMLATVTESDVSVDSESLSDATTDPNTVNEASHETTEEARNVGRLSNARRFFCLFVTFDFFFTFFMWLICVVTAHTIFQKTIVQEIINYTMETSLFDVVVITTCRFVILIAFYLVLRMDHWCVVALTTASTCAFLLAKIFLYNWSQSSQPFLHVLFIIVSFVLVWAEVCRLDIPLPHDIQTANSNSGLADSETTPLHYSYVQVSILPRENVSYFYTPPVSPNQSDEEEVDRTENSRACSLPITIAKRIPYDPFLYMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUE8</accession>
    <name>A0A232EUE8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">G/T mismatch-specific thymine DNA glycosylase</fullName>
            <ecNumber evidence="15">3.2.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Thymine-DNA glycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_014705</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.</text>
            <dbReference type="EC" id="3.2.2.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. Interacts with AICDA and GADD45A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.29" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01002135">
        <property type="protein sequence ID" value="OXU21975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUE8"/>
    <dbReference type="STRING" id="543379.A0A232EUE8"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141016">
        <property type="term" value="F:G/T mismatch-specific thymine-DNA glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000002">
        <property type="entry name" value="G/T mismatch-specific thymine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="19">
        <location>
            <begin position="52"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU21975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="428" mass="48829" checksum="5116CD7C6EDECFC6" modified="2017-10-25" version="1">MKVLVKKFNIVMSISLQKLKKRTPPQTAEKPAKKSSRFDGLSEEEVKKNTLKDILEPDLDLVFVGINPSLMAAHTGRYYAGPGNHFYKLLYESKLIPEPVNYEEDDKLLQYNIGLTNIVARATRSSADLSKSEIRKGAMFVQEKLKQFKPKIAIFNGKCIYEEFSENYDKSTFKFGLQPHRVGDTTLWVVPSSSARCANFPRMQDKLHFYTSLKKYLSFLKGEIKEVNPEEFRFQGKCKQAIPSTSKMWRRKGLSAFAHGGRIVNKETICMDTSEENILAIPRSSEFIIKNVKNESDDSQKDSGVSTLPSDDSQQLSQDNEVKENDPKPKRRQLSKRVIERKVQTRAAATAQRKEYSEPIDFVSLIKQRLSNKEQETSEDATKDCDNEDESLSHDSAGTKKLKFSNLRSTRSKKGFKVKEVLKIVDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUF7</accession>
    <name>A0A232EUF7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002136">
        <property type="protein sequence ID" value="OXU21974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUF7"/>
    <dbReference type="STRING" id="543379.A0A232EUF7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="262" mass="29530" checksum="C41B348BC0481C20" modified="2017-10-25" version="1">MPSSDKLPQQYSSRLLCRLRSTMAEKQMKSKGIPPKTLVSLVKGYPCLYGGSNHDYNDNQKKEECFNAIANSLNNRSGSKSVTGDSVKSRWESLRRSYSRGINTNSNTNGYYLAKKMYFLAPHMKKRKIGNKEVDEVVGEDLHYEDVLRVMKHKNAAVKIVPSTNTNIQKNSPIETAVIKKNIPAPTTAGMKEITNLMDSDINSYAEDNCYLLPIEEALKEISPGDLLRCTNEILGIIDKFSSSNKLFLLILDTRTRKHFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUU3</accession>
    <name>A0A232EUU3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002085">
        <property type="protein sequence ID" value="OXU22129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUU3"/>
    <dbReference type="STRING" id="543379.A0A232EUU3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263216" description="Rhodanese domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="186"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="703" mass="79947" checksum="74656B3598281002" modified="2017-10-25" version="1">MQCFVNFLFIILQTLSMQNMDPAIVAELNEKYRNLNKEVLKLNFKGRKPEHIYERLPKIYAFGSEAKEAKKHDQAYIFFKRWIACVDWLKGQHLNKEVMTKFFSNDKVEDVKKLLQEVSNSIQLECEIKPKGPQIKDSHTNSVNENFNDLELRLPETPNDEPQPKENDEITCANLFIILNQGIRSSEKRLLIIDVRKEADYLESKIAFPENIVHIPAEKIQPNKSPDFYRYLLIDDNLALDRYAKRSAKDIDIIVLMDSNSSLNSMNVKSPISMFKKSLKECDKITKYKRIAILKGGFEEWIKTYPAFVTDPVKKELSPTPSTPDSSVSSFNASYSFLDISQSREETTSPILSGRHPTGPRVKDPSNANSQVSSRSDKSSSSLYNHLLVPYQKVLASSTIANGKYTHPTTQPSQNNNPTAPPSPNCISDKQLLISNNIKEAKVVIEKLKPQVDRSKKPTLGGKPTMPTTNQLEKELSDTQYSILQYEKKLQKGMQNNWAREQLETLRKKEQEIMVKLGRTRNTISADENPGKLYPELSLSSMTLEPRTRATRLSKLNLSEEKENIPKPPIKDKIEPMIVDPQPPLTPAHMEVDEEETIRREPLKSENVSINPGLKRSHSSPNLVLQVKKLKANHQNGPKSIPAVNRSLKPNLVPKNVSRTRIASAISSKDREQRLEPIFSSIKLVSVLFLYILKASNQSFCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVB7</accession>
    <name>A0A232EVB7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002039">
        <property type="protein sequence ID" value="OXU22258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVB7"/>
    <dbReference type="STRING" id="543379.A0A232EVB7"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01167">
        <property type="entry name" value="INSADHFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU22258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="843" mass="93801" checksum="F9B592E1AED77C25" modified="2017-10-25" version="1">MEPSSSSTASNRHNEMSLEDKQLHEVKSQIPKSNFQRALCQYCATLSSSLLTLSIGMSIGFSTILIPQLYQKNAEIIVSLEELTWIGSMNYILTTVGAIASGMFAQWLGRKIMIILLTMPYIVSWLILHYSTNSWMLFTALTLSGLSGGLSEAPIQTYVAEISEPALRGSLSATVSMSIMIGIFLQFLIAVYLYWRTLVLVNLAVPIACLLLMIMMPESPHWLITKSRFDDAERALCWLRGWTTASAVREEYQTVFHAPATSRPVNEIIIDPKSSRSQSLKKAIKPYLRKAVLLPFCTVSYAFFVSCFNGSTPLLIFAISLFEQFNSPINEYTATMIMGLLKVIASLLLILLIRYTGKRKLIFLSLAGTGASLLIVAIYSYARDHCEIDVKDYTWIPTAMILISVFASTLGIKSIPWIISGEVFPTDVRSVANGLVSSTCNVYSAIASKVFLYMIRNMTMAGTFLFFTMVNVMGLIVLYFILPETEGRMLKEIEDHYAGVSMAMEMSKAVPVVGYKIFVQLMAKHDPKLSSSSIAKLTSMRNSYQNRKPVGLSLLWSFNQGGRENLAVGLKVWHEVLAPMLEAKSYASYVMKILSDLLKWHSDEETLQSDLYLTLFDTEEKNSYAELQLKKFEQEFGEGRVGFYASDVRNQHQFEEKYDQVLQSHKSVDILINLAGILCDADTELTIDVNFKGLVFCTLTAIDKMGIHRGGKGGTIINVSSIVGLMFHEDFPVYVATKHAVVAFTNSLKSHYAKTGVRAMTMCPGLTSTSMIRTDIAKPLYFVGNSSSALTNRPSQSPKTVGLAIAEMIEKGESGAVWVSEENNPPYAVRDLELYKDRAVPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW77</accession>
    <name>A0A232EW77_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001902">
        <property type="protein sequence ID" value="OXU22612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW77"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="157" mass="17691" checksum="B7EA6183E7F5029F" modified="2017-10-25" version="1">MPRLRHDQTTPANTEAAAAAAAADNPARAQPTARDDGQLDLQFLPERSSKWFKVESSLALPLFLPDILRVQFIVCVNFHDPKAEGLLNSNEVTVTSGFNGNFQISQETLQHKYTNFEVKRLGCTYCNNYSQTFRKTFTNSTKPIVPYEFVTHCDMIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWE9</accession>
    <name>A0A232EWE9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001872">
        <property type="protein sequence ID" value="OXU22673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWE9"/>
    <dbReference type="STRING" id="543379.A0A232EWE9"/>
    <dbReference type="OrthoDB" id="6057829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000013">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000975">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="600"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="933" mass="105182" checksum="85CAFA6D1DD55FCE" modified="2017-10-25" version="1">MPDKTSGNRYGAREKDFFSEEISSIGMSVRPSGSASSGISSLASCGEVEALPELPPQDEERLQRAARLLQQRLVLRQWLADHGLHNHYQRLMQMEVVSLEDVYWVEDNAARAALGKDLPRWIQARQTLPTSKEDLDVLKADLWSSVVKNSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPALAPEAKHSLLQYVTGKYLLPSNCRVHFEWDEPQLVGETMTFNVKFYQRNGQPYPICDKDNLIVEVTEGTRRVATFIELGGTDPLAANTAVVKFTVRHAGQYRIAVLIGSCHVHGSPFLKNFLPGPPDPNKTVFVRHSSTVVCTAGIAHSMTIEPRDEYDNLCVFGINDEPVEGYNVNITQIGSSTGDSSQTPCSVQLEYDTPNQRIRLKVSFPKGGCYHATVSLSGLQLHNGDFDIIVLESKDNCAVARAVHNNVASKDPDICYAAKLLGMQGEKFSKPKKVFCFISPKQLTIKEYLLKFIPKRLVTFRLCPSTKFHFDSPNNQHEGYDSFTIDDGCQPPVELISHYRDIIAATFTLFLLKNIGGSETFADKQDFFYHEVRKHHQKHYHEKLSMKVQRDKLLESSMKATKGFSVSEWCRNFEITFQGEQGVDWGGVRREWFELICAALFDPGNGLFESFGESQQALVHPNSKRPPQLKLKHFEFAGRIVGKCLYESALGGSYRQLVRARFTRSFLAQIIGLRVHYKYFEQDDPDLYLSKVKYILENDVEEMELFFVEEEYDKDGQLTKLAELIPGGSKVRVTNDMKLRYLDALAQHRLASSIRSEVDHFLRGLNELIPDNLLGIFDENELELLLCGTGEYSVTDLRAHHIANGSSPEFLRVLDWFWTAVSNFTQEEMARLLQFTTGCSQLPPGGFQQLSPRFQITAAPTFENLPTAHTCFNQLCLPDYECYDHFEKALLLAISEGTEGFGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXA0</accession>
    <name>A0A232EXA0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">RecQ-like DNA helicase BLM</fullName>
            <ecNumber evidence="17">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Bloom syndrome protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">DNA 3'-5' helicase BLM</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RecQ helicase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">TSAR_002421</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">Alberta</strain>
            <tissue evidence="28">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="17"/>
    <dbReference type="EMBL" id="NNAY01001778">
        <property type="protein sequence ID" value="OXU22949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXA0"/>
    <dbReference type="STRING" id="543379.A0A232EXA0"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="462"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="661"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="25">
        <location>
            <begin position="998"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1090"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="1111"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1145"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="OXU22949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1191" mass="134812" checksum="9551C5D613BCDE63" modified="2017-10-25" version="1">MERTKKPDSTVNSEFLKRTPGRLSLKRSTTVSPKTPKRKRLLAEKSKCGSPNGTKPKLDLIETYDTLVNLKPLGFDSKLTEWMESIKTNPLLSNSSGHSKEELQSHKMKLHEIQADIGDKFFTALNKIPEQILTKFPGYDPRVYQQLKILNQNLKARIRQTSRKMLKISEEQSNVEKSQNTSISADAISINSSKQSFDDVKLDNNDEVFEDDLKKSTAIPDLVKDVSNNDLRKSKLFSFPKISIGSAEDPTIVAQKKKSTFQLKKPMTKGAVPPVANVSKKLLMERNNDKTRMSVNKIGTLATSTVTSNAENTEAGCVINNVNQIKHCAAVRTEDIIKVDPNDFLTKLADSEGDFEVGFENNDLQNHLEDSNENELMKLLEESPDTEELLKTLPDVSELTKPPVGEEFNYNSSVVKFIGDVKNDGISGEFNNLNFPHSPEMLHVFKTRFGLHQFRPNQLPAINAVILGHDCFVLMPTGGGKSLCYQLPALLAPGVTIVISPLRSLIVDQTQKLLSLDISALYLTGDLSNEQMNGVYRKLYNTGSNLKLLYVTPEKISKSTKFYDSLLRLYRDGKLARFVIDEVHCVSQWGHDFRPDYKKLSMLRERFPGVPIIALTATATQRVRSDILHQLHLQSPKFISSFNRPNLRYTVTLRKSKYPHQLVLDLIKTKFPNDCGIIYCFSRNDCDNLAEALKKEGIQALSYHAGLDDKVRTDRQIQWVSEKVKVICATIAFGMGIDKPNVRYVIHATMPKSIEGYYQESGRAGRDGEPADCILLYSYSDMHRYRTMMESNEYANKEALKTHLDNLFKIVHFCENMADCRRALQLNYFGEMFDRQLCIANRETTCDNCLIYDQFFNLDVTKDAKALVRLIQELHRVKQNNVTALQVVDIYKGSNVSDISYKLGNTYYEWYGLGHSLTKYEIERILHNLVIQGFLCENLEPNHGIVCAYLAPGLRAKEILSQNNIKLYLQKKKAPEKVRPKKTSTTSQMSAVINVELKDLEQRCYNELLEIVNGIAGALDVSANSIMNVVALRVMSQQLPCDREAMLKIPHVTVANFEKYGKALLDVTQKYAQEKKELLIEEELNNPVISDNEDDYERMNFKTGSIGQSNKRTKSRGYRQNKRFKNNFRKNATSATTKAPITRANNKTWNSKSNSTSKKKSTNANKGNKGQNNSSSNSNKGPGLCEFTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-05-29" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXA3</accession>
    <name>A0A232EXA3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001778">
        <property type="protein sequence ID" value="OXU22950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXA3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11041" checksum="02C275BC04768BF8" modified="2017-10-25" version="1">MPKNHKSYTKINKFFTKTSTNYSSLALAFVITRNNSLQASSKPSVAQKKRTITRNQVQAAFNSPLRRKQTVAGEKPGQQKQQTWYTSIINFETDISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXZ9</accession>
    <name>A0A232EXZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001696">
        <property type="protein sequence ID" value="OXU23195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXZ9"/>
    <dbReference type="STRING" id="543379.A0A232EXZ9"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58005" checksum="5FC4696E18DECE3E" modified="2017-10-25" version="1">MSAISLLNPKAEFARAAQALAINISAAKGIQDVMKTNLGPKGTMKMLVSGSGDIKITKDGNVLLHEMQIQHPTASLIARASTAQNDMTGDGTTSTVLLIGELLKQADVYISEGLHPRMVTEGFDLAKNKTLELLDKIKLPIEPTKEALLDVARTALKTKIHPALAEKLTEICVDAVLTIRQPKIAIDLHMVEIMEMQHRTSADTTLVKGLVLDHGSRHPDMPKKLENCYILTCNVSLEYEKSEVNSGFFYKTAEEREKLVGAEREFIDNRVKKVIELKRKVCNGTDKSFVLINQKGIDPPSLDMLAKEGIIALRRAKRRNMERLSLACGGQAMNSFDDLQEEHLGYAGLVYEHVLGENKFTFVEECKQPNSVTILLKGPNKYTLVQLKDAVYDGLRAIKNAIDDGSVIPGAGAFEVAANQALLQYKNEVKGKQRLGVQAFAEALLVIPKTLAVNSGFDSQDTIVKLQEESTTLNQAVGLDISSGEAIDPKAAGIFDNYIVKKQIINSCTVIASNLLLVDEIMRAGLSSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYL1</accession>
    <name>A0A232EYL1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exportin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Importin-alpha re-exporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001630">
        <property type="protein sequence ID" value="OXU23377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYL1"/>
    <dbReference type="STRING" id="543379.A0A232EYL1"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU23377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="987" mass="111501" checksum="92E52B03D629B9DE" modified="2017-10-25" version="1">MTMELTDDNLLTLSEYLRHTLSPDVAVRRPAEKFLESVELNQNYPLLLLHLVDKPDVDITIRIAGAIAFKNYVKRNWKVEEDSVDKIHSQDRDAIKRLIINLMLHSPDAIQKQLSDAVSVIGKNDFPDKWPELIDQMVGFFNTGDFHVINGVLHTAHSLFKRYRYEFKSQVLWTEIKYVLDKFAKPLTDLFLVTMNLTQVHANNVEALKVIYSSLTILCKVFYSLNFQDLPEFFEDNMASWMTNFHTLLTVNVPSLRTGDDEEAGVIEQLKSQVCDNVCLYAQKYDEEFQPYMDQFVKAIWNLLTSTGQQPKYDALVSNALTFLATVADRSQYKHIFEDPTTLSSICENVIIPNMEFRGQIFLDITSFKCKLKLNIKSDNELFEDNPEEYIRRDIEGSDVDTRRRAACDLVKVLSKSFEAKIMEIFGAYIQAMLQNYVAKPAENWRSKDAAIYLVTSSASKGQTQKHGVTQSSDLVPLPQFAAGHIEPELAKPDVNEFPVLKADAIKFIMIFRSILPREQVVGSLPQMIRHLAATSPVVHSYAACAIEKILALKGPNNVALVKGTDIAPLAADLLKCLFAVLDSPGSEENEYIMKAIMRSFATLQDAVVPFLADLLPKLTQKLEIVARNPSRPNFNHYLFETLSISIKIVCKSNPKAVASFEQALFPTFQGILQQDIQEFIPYVFQILALLLELQTANDVPESYMALFPCLLAPVLFERQGNIHPLNRLLQAFVSHGAHQIIAQEKINALLGVFQKLIASRTNDHEGFLLMQAIIERFPPNALEPYIKQVFILLFQRLSSSKTTKFVKGLIVFFSYYVVRYGASNLVTMIDSIQPQMFGMVVDRVLLTDLQKVSGEIERKVTAVGVSNILIDCPAMLQSPYNAFYPRLLAALVEFFELPHDETQLPEDQQVLEIDDNSGYQAAYSQLIFARNPKVDPLPTVTDVRFHLAQGLGRMEPGQLPGLLGQIPEPNANHLRSYLQTAGVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYM2</accession>
    <name>A0A232EYM2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_002179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001620">
        <property type="protein sequence ID" value="OXU23409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYM2"/>
    <dbReference type="OrthoDB" id="10650472at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759835" description="Spaetzle domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="5">
        <location>
            <begin position="397"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="501" mass="57434" checksum="A5CD164EE889DFEE" modified="2017-10-25" version="1">MAGTISKAGLLLLVALALFAVTATCVRRRMDGSCEYRYHRFRSGRRRYGREVVEDEQYIVSDYYTYINNLAFFIEREFLNDCIGFQRDYYGYNTDQQKFGTSCREAICSNVNGYPSQKINDAVKLSPHPDMADKRTEIDLEVLNFEFRPQIRRVNVDGCGVHVNVTKPQEGISTDDERHYLIVNIPSLQQPIQFVECLGGKSKSLKIEGDSTCQQAYREEPFLTLPADVDRHYEARDFKIKKFRVTDGCQCDDGVDLVVLDVEGIRTAVRRCIRRHPNGVCASWLRPKDILRRSQPNDMIHRLGREAKNDQYASNYYSYSANPEQFRTSCHKAICTNALGYPSERINDAVNLVRRIMTSSHPNMVNKRKEINPEVLNFHSRSQNKVSNEDVEANVDGCNIHANVKRPQEGISLDDERRYLIVNIPSLQQRVQFIECLGGKSEACDVEGDSTCQQAYREESLLALPADLHRRYEARDFKIKKFRVPNGCKCGEGVDLVVNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ46</accession>
    <name>A0A232EZ46_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001572">
        <property type="protein sequence ID" value="OXU23557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ46"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012308286" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="93001" checksum="155268966CD7AE5C" modified="2017-10-25" version="1">MRHSKEEGAEMKLQASWLAVLLCFVVAGVSCQENAIKNISPSLIECYDGDTYEKWNLLPHSMETLIAIIRKIEDSPGLNMDLRQLSTAILHRFRQDGIVRNPRVKPQAGIMPYAPLGKQFFRHAQTLRVIPGNALTFPNNSISALERCTLHSMLSSSIDIFERGDESRVCKVANYAYRRYSRSAEIREKNVKEEVETLTAEQLEMMSKADIVDPNSLYPALPPNHPSSARLTDLPPASRCPTENGVVKTRWGTVSGGSVLAGIAAGLTPQQIRIGDLIRQTEQRVTSYSNDASVVNKFLGTLAGDLAEVALLQGPQLSGRYILGVDGNWNSSSQPLYYFLNSNENLEMTASEVRGDLDGLILANELPNYYPSKIGGLRLSQVLDMYYSNRGLFDRKNRACNRRAQLYDVAPTPLLTNQTHNAAIILSSGIAAATFSSEAIRKFATQAVNELGTLVPTMNSDTCDNRESSNSFADVSEPAVDLTIILDTSWPFENIKAIISQLLSGLSISKFNSNVTIINGQDGSIMINSTYDPNDFHYLFNLTNYRKLPVKGFELSRSLEKLRAYQTNKLNDEKRQGRAGGKSDVVLFVPYQTNAPQSDKEYCLSTIKTMQEEVPDAVILFLTYGSKDRWGEYVRESNDDLFSVSIGETTESYPAVDSLQTRIKQIPRRLVNTQCGADYESTDPRSSKALMETVVPGGSNFYRIHPNYFSSDDTENPPRVRIQASGIGSLRVCSSRELLHVNTSEAATSANCISLTSNSHIITMNCEDASYLHQCKPYYVSVSSNSTGPSTFACNDPKLCRYPDSVKYTISFENLVCKSGASTLFAVPLLLLLLLAQLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ95</accession>
    <name>A0A232EZ95_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_000859</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel HCN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001523">
        <property type="protein sequence ID" value="OXU23701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ95"/>
    <dbReference type="STRING" id="543379.A0A232EZ95"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000229">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0114">cAMP</keyword>
    <keyword evidence="6" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="470"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU23701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="679" mass="78244" checksum="98B3F7BDD5FC58CD" modified="2017-10-25" version="1">MNYKGSGKVHFGVDDVSLYGTPKEELGPGLPGQEVKQSFIKNQLQALFQPTDNKLAMKLFGSKKALMKERIRQKAAGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDLVVNFRTGIMQQDNAEQVILDPKLIAKHYLRTWFFLDLISSIPLDYIFLIFNQFQDFSESFQILHAGRALRILRLAKLLSLVRLLRLSRLVRYVSQWEEVYILQNLQKKRTERRGRLSSDNMNKKKSGFSKSDLIFKFLNMASVFMRIFNLICMMLLIGHWSGCLQFLVPMLQGFPSNSWVAINELQDSFWLEQYSWALFKAMSHMLCIGYGRFPPQSLTDMWLTMLSMISGATCYALFLGHATNLIQSLDSSRRQYREKLRLTHLCLNQVKQVEEYMAYRKLPREMRQRITEYFEHRYQGKFFDEELILGELSEKLREDVINYNCRSLVASVPFFANADSNFVSDVVTKLRYEVFQPGDIIIKEGTIGSKMYFIQEGIVDIVMANGEVATSLSDGSYFGEICLLTNARRVASVRAETYCNLFSLSVDHFNAVLDQYPLMRRTMESVAAERLNKIGKNPNLVAHREEDLGSESKTINAVVNALAEQAAHASASEESVHSMELRSLPTCLLPRPKSENNFASQELTREGRRVFHKSDTFHKDSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZA9</accession>
    <name>A0A232EZA9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001595">
        <property type="protein sequence ID" value="OXU23478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZA9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="91" mass="10588" checksum="EEB86E70CCBF9E3A" modified="2017-10-25" version="1">MFACLLYNPISPHEYFYIRPASLVGDSKQSFLKEKKEACMLPSLFPNKDCITQQISFSSINIVLFTKSKYYFPTNLFADSIPKLFVDRNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F049</accession>
    <name>A0A232F049_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001427">
        <property type="protein sequence ID" value="OXU24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F049"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="29" mass="3376" checksum="47CB724548A49C78" modified="2017-10-25" version="1">MIRFELLSFLFSVRCYEKLLASLGALVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0Y0</accession>
    <name>A0A232F0Y0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001370">
        <property type="protein sequence ID" value="OXU24210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0Y0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12694" checksum="78CDAD5BC8E8406B" modified="2017-10-25" version="1">MWILYELSTCAPPVECREISRFEKYAMPQKYRQLARHNSVCNEVYYKFQDCEIEHPVARFIGACTQFQKNLEKCIKANRETMRTKNREMAEARRQKFNAEHASTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1D5</accession>
    <name>A0A232F1D5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001257">
        <property type="protein sequence ID" value="OXU24596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F1D5"/>
    <dbReference type="OrthoDB" id="6084525at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF0">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="537"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="4">
        <location>
            <begin position="643"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="5">
        <location>
            <begin position="1415"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1322"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1615"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1662"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1719"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1808"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1900"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1719"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1861"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1900"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1912"/>
            <end position="1929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1929" mass="213327" checksum="3E136807AED9FE25" modified="2017-10-25" version="1">MRKAALISHRFQIAFGITEENEEEVKAAQELDESQDSSQDSTIICLPSFIPSDDGTSSLLKPVVEQWQEITVNVEPSVSKVPALENVLMLNGNIAPTRRQTMPEISSDQLSMLGGKSSLAAPIETINTRRSSITNVAICSSIGPSLAGIFPGAPSNLFTDSRMAESEPAPQLLASSLRRSVTFSALNEPLTLEEATLHRTDSMVSLCYRTLANYVSDDNLAGLQNFLENKRVQVDDRDENGSTALILSASRGKIHFVRELINHGADVNAEDADNWTALLFAAKEGFNDVCIELLEHGAALEHRDAGGWTALMWATYKGRTSTVTLLLTRGADVNAHGNYHISSLLWAAGRGYTEIVKELLAYGAKVNVGDKYGTTAIIWASRRGSLEIVDALLKAGSTVDTAGMYSWTPLLVATLGNHVEVVLLLLDHKPNVNAVDKDGCTALSIACREGYFEIANALLNAGAYINIQDKSGDTNLIHAVKGGHRGVVEALLKKYADVDIPGKDRKTATYIAVEKGNVSILKVLLTANPDLEIATKDGDTPLLRAVRSRNAEIVQLLLDKKAKVSAADKKGDTVLHVAMRARSKGIVEILLRNPKNSQLLYRPNKQGETPYNIDINHPKTILGQIFGARRLNTNEDNENMLGYDLYSSALADILSEPSLSTPITVGLYAKWGSGKSFLLNKLREEMKNFARQWIDPSFQFSSLLFLIVTHASLLIGVTIGLICQSWVTGLVSGASLVVIVYVFLLLVWHANKRYDWYWPYNFTVALSTKLNSLKLLLQVTFCHPPGNQTHDGITIQPIKFFFTDQTRVGTTTAGENAVVQMVGSLYDSIESEFGSMSTRLYRAFRPKPVKTTASWKWRHLCCLPYVAIFEFCFCSLLVGIAILTVYLIDSSQEKETPVIERVTAYIIMISIAVLLAVSVIANLYTWSRTLQSLIFSQRRQLRRRIAKLETLKSEGFLQTLRSEVNLMTDMVKCLDSFTAQKSRLVVIVDGLDSCEQDKVLLVLDAIQALFSDNGCPFVVILAIDPHIISKAVEVNSRRLFTESNIGGHDYLRNMVHLPFYLQNSGLRKVKIAQQTALHSNKKTTWNEAEESVNYATTNPLTRSVSNRRLSTESGVMNSNEKLKPPSRKGSRKLRLSESIASSIGSNLNRLGGAQDLNKMLLTDDYFSDVNPRSMRRLMNVVYVTGRLLKAFQIDFNWYHLASWINITEQWPFRTSWMILYYDTSEDNLDDSMSLKSLYDKVRPQIPIFKDVQPLLEMDRDERKLDVFLTFHRSSLLVSDMKIFLPFTINLDPYIKKKIKEEQQTMDEESNHPSLYKWNNSMSSAGGPSVAESGWTNRSGAVSRHSRMHKPNASQLPSGLTPGLSQLSPIPNMWQPNARPLYDWQMPHWPSLPPPMEPIQKPLSAVTNLPSDILDIKLSILAVDGLCDLLDKIQDLNQNQIPHYKEIIKDNNINGRVLLHCDLQELKNVLKMSFGDWELFRMVVVSLREQELTTFTTQEEGPRSVRFIVGPDENIRKSEHTTQNNPIRVPAIVEKDKSLSRTDGPPRRDQAKQSIMEKQVTLEEQMICGALQTLNEEACEDVLDVPVSPAIVPADSLPGEPSSLPLTVPLVIVQEPPRSDQSPDSVNDADGPFAGDRARSRASSVCQDTDYVILQSNPLLHWVPVSDDPGDDDTSSDSSLDSMTLPPIHRTSSQRSISSRCSIASSCSVNHYRSPAAAALHQKSAAAKQSRRPSSLLVSPPASPRPASRSKSTDDYGSDTLATSSKRSLGPRRSTSSLSEEITISIPVPNTAAIGLGKLSKLKERLLNKSPQQPQQLQQGETAVVEDSDGESTPLVSELSSPSHSNSDSVFKAASPEDESSDSLSPIDSTTIKNLHRGGNHSSTEVLEHYVDSVGLVVHESASSSFGSRSLSRQNAQDWENPETPSELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1N9</accession>
    <name>A0A232F1N9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001213">
        <property type="protein sequence ID" value="OXU24716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1N9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="18040" checksum="0A648B4DB0DA307E" modified="2017-10-25" version="1">MSSSEEEDDYHQQKSRSLSSNRFACCEFKGFLMRSNLTLTRAHGKNHYFEYAERYETCTHCLRDLHESRKYCDNPFDNHQSGKILRHSIVPVTGKLANFKKYPAFKYCRYVCAFCVYKAKKMYNQKRGDRHILCESKPKDLTIINESDSIQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1Q0</accession>
    <name>A0A232F1Q0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001290">
        <property type="protein sequence ID" value="OXU24472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1Q0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012579194" evidence="2">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="216" mass="24768" checksum="1FB2FB49EC5C9796" modified="2017-10-25" version="1">MKKLMFATFILFCIFASVSAFFVETSNQQVNGTVVSEKIRKNADKVESRSNDEFDDSSGILRMLSTFKYLRSMYLEFRSELKFVYCISDHFLKIDYFMDSIPTPRFSNKSIEADKKCDRPEKNSISSYQDGAKCSNTSDSTADTELPNTDTRVSLSDSESVGRSLLPINGVPESFLVAIGGLVYMKRWIEDLIDSFGVLECTRRYLWILFLRWMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F208</accession>
    <name>A0A232F208_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein misato</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001180">
        <property type="protein sequence ID" value="OXU24836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F208"/>
    <dbReference type="STRING" id="543379.A0A232F208"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="5">
        <location>
            <begin position="134"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61211" checksum="4962EF2AE437532D" modified="2017-10-25" version="1">MATREILTIQLGHYANFVGTHWWNLQETNFSYDPQNPSEFNPEVLYRVADVGNKVTSTPRLLLADLKGTLGYLSEEGNYSELVQANVNQEPEILWEENRLETTVQPPAQKSAFVKSLESGESNEGVEFDFENETKSWVDYLIPRFHSRTVNVITEYEHGSTSQPFDLFPYGQSLWKRSAFSEDFADKIRVYVEECDLMQGFQVLFDTDDGFSGLGAACIQHLRDEYGKSILTWPVLDSTPREKSISDYAKAINTVLCWHNIGENTSLFSPLSCGTNGWLTPGKPRALENITYRSDLKYHTSALLATALDTLSLRYRHKKYTMSALSDLCADLNKLGRKAVATSLSLPFPMVEKQDLIDMLDDLDGGCPWVSLTPSCNIGMDNAMQSLALRGVPESRLKRPMQEAQDQMIKPAYKCSSVHEMLSLYINCSWYSTGTYLTTAEQPLKIKNPYPKIFNSNILENGDSSRNKSRESNVNSVPVMAGLHSGNFMAKMYESLHDQVKKVRNLNKFHAFVDSGIEQDEFMESVHNLLDCKESYEDHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F278</accession>
    <name>A0A232F278_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="13">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSAR_001482</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Alberta</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-methyl-ATP + H2O = N(6)-methyl-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(6)-methyl-dATP + H2O = N(6)-methyl-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>O(6)-methyl-dGTP + H2O = O(6)-methyl-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01001222">
        <property type="protein sequence ID" value="OXU24692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F278"/>
    <dbReference type="STRING" id="543379.A0A232F278"/>
    <dbReference type="OrthoDB" id="408303at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="24">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00053094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OXU24692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="161" mass="19011" checksum="F69AFB83EBF9E9EB" modified="2017-10-25" version="1">MTARKLLSLVFVRKQAEILLGLKKRGFGEGKWNGFGGKVEANETILQGAIRELKEECGLSTSELRKIGFLEFEFEGDPTLLEVHVFETYKYHGEVTESDEMRPQWYDLKNIPFEKMWPDDAYWFPYMFREEPFKGYFLYRGIDLILKHKLEKLDLEKLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2A4</accession>
    <name>A0A232F2A4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_000941</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001244">
        <property type="protein sequence ID" value="OXU24620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2A4"/>
    <dbReference type="STRING" id="543379.A0A232F2A4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="473"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="744"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU24620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="986" mass="110741" checksum="2B2A8EBAFCAF016D" modified="2017-10-25" version="1">MLPTFLLCESEKGKEVMDIFDRRYFVLNKALLRSTGLWPYEDRRKKLYIRTFVNLILGICVIFPQIVRIYNYFGVNMNMVLEHAAVLMYITSIYLKFLTSVYYEEKVLTLRLRKFLILMRFIVTHMSHIFTTQLRVVYDNIAKNWQVIKDENEVSILIQYSENGRLLTIGYTMYIIAAFCSYVFLPIVPVLLDVFNPLNQTRSRFYILGGEYFIIDNVKDYGKVYAFDCLAVIVTVWLISAVDSMYAASIEHCLGLFAIVKLRLQTCTRSICDGQKDESYKMIVRLIRMHKDIIKFSMEGILTFDDILESSYSSSFLILVGINVIFLSFECIIVLTRFGQAMEMMRYSMIMVGIVVHLFYISWPGQKLIDFSLGLFQDAYLNEWYTCPTRAQKLLGLMTLRCLKPCQLTAGGMYVMNFSNFAKIVKTSMSYMTYTDQLARMNRISSILYLIGIIYCQFNTVLGNPDSNRQPKIVNAYPAQTNQFPYLVSIYHTGKDHDCGGGIMADQYILTAAHLVDTVDSVHNTGNRIGVEKAYVLKSYQHPRHDKDIGILKLNESLQLFGNPQRRKLDLPKIGTDYTGEAAVIAGFGRTDPDDRSTMGEHLFYSAAKIVSNKDCEDDHKKSSFFVTENHICAKIMQSFAGVHTGVCNGDSGSPLVVDGNTVVGITSPSAANCDERRSPSRYTRVSSYLSFIKAVVTGQLNNKIAEYNVPPPPKDDPCASFLTIRNTYHLSHTVAALLDDEGIIGGEEASPNQFPYLVSVYRTNSRHNCMGGIINDRYILTAAHCIVNPSTGRFFNIPMEIVVNTLDLVNDTGIGINIKKDFAEAGDPNDIGILKLSESLDLSNNPQRQRLDLPKAGIDYVGRDGSGDSGSPLVIDNTAVGVTIVAEDNCDERLKPALYAQDSRYLPFIETVLSGQLNTLLLCLFSIMSSSLSNVLGMPDSGRRTKMIGGKEAKPNQLKYLVSIYHTNPQHNCGGGTTYAASTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2X8</accession>
    <name>A0A232F2X8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001087">
        <property type="protein sequence ID" value="OXU25186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2X8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="51" mass="6298" checksum="80C7521895668C3B" modified="2017-10-25" version="1">MLQHIFDKYIKWRGSARKASSRSRRCRGARDTIYFYIVVRIFHDTEKNTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3A3</accession>
    <name>A0A232F3A3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001092">
        <property type="protein sequence ID" value="OXU25155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3A3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="395" mass="45561" checksum="DA49ADCE1A3C771E" modified="2017-10-25" version="1">MAEGISEICELSTHRIYCMIRLTMELVTVTDGTRSYDFMLTDGVLLLEDIQPFFEKACALLYLLNERKLTVSCRNGAFKIPDTVSSLEVICGQNASPTATKRTFDNAILSVIDKHKSKMHKISRKKEGRVVTIKKEIHLGWRHLKKNKYFAMNEATCNEKVLYIDENTEYSYEDILQQCIDKLSDARNVNFFKHSTALLGTFKEDIFSKFTDEQRNHYSLCVYTKPIENPELVNIDRNLNVKSPQKQPVRTVLGKIKENNHAPEQSSKETAIMMKKMGSEPWRDHRAAQLILLLHLCWNNLKDLEISTPIIKKEEITFTSKLLGQGSFVKTLRLGMNYKKICLEIAVMDKIRHSNVIIIMAVAYDISHCYIVMKLFDSISLREFNSIQVSRTIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4C7</accession>
    <name>A0A232F4C7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001054">
        <property type="protein sequence ID" value="OXU25328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F4C7"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000001">
        <property type="entry name" value="Ral GTPase-activating protein subunit alpha-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF11">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="5">
        <location>
            <begin position="1561"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1824"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1547"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1888"/>
            <end position="1898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1898" mass="213061" checksum="6E0377C2F9CBDF7C" modified="2017-10-25" version="1">MFSKKLHVDVKKSTLKIQDVKKDSATRFKHLKIVLDNVDTDEAKGFFEANFSHVYFILYDCFVSAETNLRQRVHKAHREELEQVLQLLEKVLTLLPELLNRRWQCHSLARIIHKLLHPGNSWKLRRQAIRYFILWYQALGDNAPEHIHQMFACLVPSFPPRQPSPYKSERKVDAKSRHTKSASCDEKEKKEFYDTQLNQCVFHDGGGVTQGPISQVDSGPILPPQSGEKPLDNEPVKFLEALLEFMVTQVVKIEWRDKPSRQYRAFQFLLDRFKATYLKYICPEFNSSFSLYKPNLELSSMRKPTNQSQSNYVLCKVALVKWIATFTHVAKRDGAFSHLTQSITPSEESAEELRRVSMSQTPQDASLISTDQNISQDNTNQEDSTLTAMTLVREVLYGSRDNVNFIHEMYRQAFLLDFTHAGAIRKAIGAYKDWIQMNEVPPFMLEPLDGHRDKDYEENQKRDAEADKSPQDSLRFSRLRNDSYLGAIHRENLFVRAGLQNVLQVFITQASNVFFLECAGGTASATLLEEQTDSCKRVLNVYRYVVMHSRLEPPTWEQLLRVLLQITSLVLSEKNPRRKHQDSIGGKLAPAIFQTLIVTWIKANLNVVISTQLWDQFLAVLTSLTHWEELIREWAKTLDTLTRVLARHVYNLDLNDLPLDRLSEQKSKKRRGVGSRAASTGSVQPPRRGSVDQETTQSSKEVTDNAFRELRKARPLPRSASDNSIYNGKIRSKIHRNRSQTGNSGIPEQDMARLVSSMRSSSKRSLGRRAKSLESVVVPESEPPTPRCPSPTPSSGVDSNKDSPIQIENIDGNSIDTSDASEKRSVMAGGGVRGWLPDVAVVLWRRMLSALGDVNNIQDPTLHGQVMDYLVQLTHTLIKIRQNQGVSGDNQVTPPAPELIPPLTIIAPWCFKAIQLPPQYEAGKLAAYRLICLLTIQPQDVSLPKQHLTLFYRAVHHGISSNDTKILHTLVKYTGPRLFSLNLPGSSLLVLDYIQAANVILSSQDIEAPRMEAVSILGSLLSLPVINVNTRVLQPNEAEIVTTTCPYAKDHIIAILMRCCRREPTGIARCIALSSIAMFVYKELSYKSLHRTIPEAVNVLLLSLKCSIGTSRQRAQQAVRRRDKFHFLLMNQTNHATVAQVACDCLLLLCDKADVLLEQYPNVPAKIIQSLSETLERSMIRERKSTLTISMLFCLGEWAMHLGPSMLLRVFQGKPLLLTLFSVLDNIVQNKSSKDSQEVSKAQPEKEDFEPSIALDNLFDESSSKSLWRGNIQSVQLAAKMVMMHLVNHLGHFPMGIGAARLSSLVVELDDVPGIESDELSSAMFHAPNIQLLMLSNSIIMSLIELDTLDAPGGGVTAGLTTAPSMVRVLLRDLAGKASWDSSILYNQPSNDEVEVSQTKPECAIKAVKDDLCSVMPLQSCPPRHTMRHHDPDILPTFENGASDMDNLDDLLQYIGHTSPEVLTNPEVALNSPAGPPQGQHFESETIAAILNQRNAEREHVNNWSQHVSMCAAPITPPACRPPPAPFHHCRLLFSHLGLSGWEQRRKLHLLSKNEKLLRELRNLDSQRSRETHKMAVIYVGQGQEDKNSILSNVTASKEYENFIARLAWEVELESHTGFMGGLVPGKASGVTTPYFATSFAEVIFHVATRMPSDSPESLLQKTRHLGNDEIHIVWSEHWRDYRRDIIPTEFCDVLIVIYPLPNKLYRVQVSRKSEIPFFGLLFDECIVEDAVLPGLVRTTALAASRAKRSTLTLYQQYYEERARSIDTIMRNHKEATTFEEFAANVYSPVQPPSPFSGASSVSGSTTSVQSAASSNLAAALIDSHQGRPGLRGTSTASNDNRANRVSDGSRVWFSSDTADSTAFHGISPRPAKKMSFKTGPKSKNNPQPTPPDSPRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4G0</accession>
    <name>A0A232F4G0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001044">
        <property type="protein sequence ID" value="OXU25368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4G0"/>
    <dbReference type="STRING" id="543379.A0A232F4G0"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="4">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="191" mass="21921" checksum="C79A6140517C6595" modified="2017-10-25" version="1">MAQMSFIKVITTDGIFKIDLDIAMRFKTIKTLLDDLGIDPKEVDEEIPLPYISSEILSRIVEWASHHRDDPVEDQEEDIYHQKTYDLSDWDRTFLETEREAKRLIPLIIAVNFLDIDSLMGASCQYVWGLISNKKAHEVRQLLKLDPIEKRKKSTQNTEVSPVESNESNEENIGNSNENAIDLSTSNRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4J9</accession>
    <name>A0A232F4J9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCDC92/74 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001033">
        <property type="protein sequence ID" value="OXU25408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4J9"/>
    <dbReference type="OrthoDB" id="2155209at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040370">
        <property type="entry name" value="CCDC74A/CCDC74B/CCDC92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14882">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="411" mass="47199" checksum="CCBE15810EA7B47D" modified="2017-10-25" version="1">MTSKVLVKLPLVPFSQRKKPPPEIISLPNRNDESDEGRFQGHNSDKVTQLEQNMKFLQDQHQATLVALHQEVEILRQRNRDLQFQLIFSKGTNYASSSPSSPEDSGNGFAKPKQGSPASVNVAPLQVELLEKDLQDMKSSLNEAKTRNIYLSEVIEKQKKSLELSEKSKEKQKVTDVGVQVDGVLECQQVELQARLDDAEALVKRLRQENEDQRKEIATIKSSSSAGYNSNGNNSRSGSSRNRGAGQNAYHNRGPPANDQGQEENYHKFPPLQTQSYWHRASRGNHSYDHNSQSDYHRNSRHHQDRQELEADLDITTVLPQLRNGSVRVDNSSSYPPFFRSRGHHSGGNYYKDERGQQNRKYRGQKAQRDRRDQEPREYHREYKDSREPKENQRQHQFSESAKGARNSQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4Z0</accession>
    <name>A0A232F4Z0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP18 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000931">
        <property type="protein sequence ID" value="OXU25851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4Z0"/>
    <dbReference type="SMR" id="A0A232F4Z0"/>
    <dbReference type="STRING" id="543379.A0A232F4Z0"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000002">
        <property type="entry name" value="Pre-mRNA processing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor 18 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="336" mass="38855" checksum="AC0146ABDC42BDFA" modified="2017-10-25" version="1">MDILKAEIAKKRKELADKNVLQNNKKYFRRGDLLATEQKVVNDTNSSSNENDADRRAAAENSMIQDNSQNTLPRAEVIRKLRERGHPILLFGESEIDSFKRLRRCEILEPEVNKGLRNDFQEAMEQVDQAYLDEILKSSKPQEQRKKGDVHVPDEEVTYEDIQKMAENLDKNNRETDMHIITTFLQFLMKIWGDQLNSRAGAEKMGAKGKMDSAIYAQTKEYLKPLLRKLKNKSLPEDITDSLTEIVKHLLERNYILASDAYLQMAIGNSPWPIGVTMVGIHARTGREKIFSKNVAHVMNDETQRKYIQALKRLMTKCQEYYPTDPSRCVEYTKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F564</accession>
    <name>A0A232F564_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_010177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000983">
        <property type="protein sequence ID" value="OXU25618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F564"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1150"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1174"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1326"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1381"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1407"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1466"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="786"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="942"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU25618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1516" mass="167975" checksum="99566CCCBA997C94" modified="2017-10-25" version="1">MPLVRKPMRYAHPEGHTDVCYFMGEKGGLVTCGTDGDVRTWIDLMDDDPSASCISEQAIAVVSKKGKLFVGNDNNTVQILSHPDLEKAGILARFSAAVSTLSTTKDSDLIASGACDMRIQVINISTSDSFELNGHEAPILGLSLDPKEEFLASSSGDGTIRIWSIKDKKSVHTWNSVVPKCNGFFTAKVYATPSFQSKNGEYLAYPHGKEIIVVERSSWKEIFRLRSTDIKNELSICKFSECGTLLAASSTYGEIVVWNVDSKEVVGYVEHQQNAKITSLVWNPHKSDEIAFCDALGQLGCIEVNISKSFDDLKAESITDGNIADDNFMFNDNDDEDDNVISLSKIKASVIDEDQKSVSSVVTEKIEEKRTLPEINLQEPFQPGSSPVHLLSRYMMWNDVGIVMCFKSEDDEDSNIEVNFHDVTVHHSMHINNYLRHTMAALSNEALALAAPAYDGSPSKIVVVALQGWGSGNKEWSMDLPDGEEALAIAAGNNFVAVATSARTLRIFMPGGSQREVLALPGPIVAMNGYGNNLAVAYHSSIGAFGDQILSLLWVRICGPNLKSHTLPVPLSPASNLMWLGFSDLGSPVVMDAEGIINIYDKKAFLWRVASNTNRQNKGKFDSYFIIGISESERSARCILCKGSHYPPTTPRPIVTEIPLIIPLCDPESEKSEKESKVWQLGSNPVDEREAVLALVANACRNNVQFRAVELCQQIASQKVIELAIKYAGRLNKIALANKLESIADTKEPDEIIREVGTQEDIFNDRIETPDEDELLVTPSVKTPDVEIKPLTPSQTFSRRNNPFKKKGNTPVSKGLMGLDKLPEKPKPVSTAPISAPKSKKPKEPPTHSFVNWLTKNKKKVEEEYADLEPNQRMKIAYSRFEEETKSRTNTNEVSDDETIIRRITRAQSEFKVCSDTKYITRNFIETNQAGVALSYTTSSLPKRSFVSREQENEKQEESSGGEREADSRALSRLQHLPRATSLHVQNDDEDEDMQEFKEEHPEEARMQAKPTSKGKGPVDLVQEAMGTLGPWHIVIAVAVSLVKFPVAWHQLSIVFLAPDVDFTCASPKPFNSSMALDKHCSVNVGNDTVEKCTKFHYDRSIFRETIITEWDLVCDRKYLADLVQSLTMFGILVGNMIFGIMSDRIGRKIPLMIAIFIQSVTGFVTAYSPWYEFFLVFKFISAVATGGTMLISFVLLMEIVGPKWRSTLSVLFHLPFLLGFLMNPLIAYLTRTWTGFQMAVSIPPIFLLSYYWIVPESPRWLLAVGRTSEAEAILTKAAEKNRIPLSKVTAAIEAHNVQAKAQKKQEVKYNITHLFRTPNLRIKTLCICVNWFVCGLCFFGLVQFMGKLAGNIFVNTALSAAVELPGTIIVLYLISRVSRLRILIGGSAVSGVMLLLLIFFENPTIRVTLATIGIGGMSLSFPTVYLYSSEVFPTVVRNVGVGAGSTCARIGSMIAPFVVRMGGTWPWLPPLLFGSGLLFGVALCFFLPETMNCDLPETIEDGENFGKKRPRKNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5J9</accession>
    <name>A0A232F5J9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000914">
        <property type="protein sequence ID" value="OXU25945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5J9"/>
    <dbReference type="OrthoDB" id="8190486at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051299">
        <property type="term" value="P:centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902410">
        <property type="term" value="P:mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038923">
        <property type="entry name" value="Centrobin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439:SF1">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="815"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1062" mass="121383" checksum="DCA03F1381BF27F7" modified="2017-10-25" version="1">MMSDSDDTDVLLLIPPDLFLVPASDSDDQSDCSSYKKNKSGVVSELIDHVQSLETRISAIESKDSPNNSFSLSRRLSLDSIMSCRQTLPRTKSSVSQTSNLQKTPTKHPSCLSLPSTPSIRQQLQHTNETLHSTKSSGHYQSNRSNPNLWNKHDNVKPFSDPVFPNTSSPNKSYLHVGNGFLESKEPHSLLTPGTNVCENNVNARSFNSYNTLVGRLASDSKSIKNMSLSEVEEFLQEIESNDKELTQANGYSNDQQLQEDLDKITEKKSYLTEEDEKNIRRIMEQKLKFSTNGYSQSREPLHQSDHERRKDISDLTLPNDNSFSSFDTDKFMTEFKAWTPSLHNGLNDSKISISELRNFEENERLRSSQQKVSDQQLDGNNVQNYVTASTQYLDSSLLSKFADQFTNPQVISSSAPEINQSTLLASCKSCPSIFKNPNNISTSNPLDSLGKKSGIPNGQNSASTLRNHDSSTQRPQRLLTLSDFWNHDSSKSQEEQLRIKLEEERFRREHCEQLIQDLQKKLLEQQERVAVAVRVDAEKNTLISQFQITWKKMKRKLSEVESERGNLQKVLKNISDKHQSEIEHYEKQMKNCKEELSKALNLATGYKEKSDCLVKEKVELLKSHADELQSYKLLVQQAESRYEEMKAEYQKLLEKNQQTDEAFKAIQQDLNKELLKGSEVRTEMAVIHKALDACEAELTILRQEKESLQLKLKEEINRNNILEQGKASLIAAVDEAKKAEKAALNEVQSLSDQQEKLRAELRDVYQKQVDDVVKTKLQEFQTQLDSAEMVFQNEIETKQRAIAECAARKIKSVIDKHQLEINLVEEKHKEEKRLVEIKLAQAVQKSAMLEAQLNSYRKSKNQLVEQLHSMMQKQWQQALMIISGGNGDQMSSFQKINVDKLFEFPSEINLELVPNHCSTLHSEPMKLNALKSSLSSQNVQTQERENESLVTLTSHNETPLTSRKETKSDLRKYIKMLLDMQQSKEDNSKPKFFDRSPPLSHKDNSDKQSLQKDINTSNDGSSTWQPTSEMSIHDTSEYLSVPQTQKFTFKGDQQRQKPPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5Z3</accession>
    <name>A0A232F5Z3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000927">
        <property type="protein sequence ID" value="OXU25859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5Z3"/>
    <dbReference type="OrthoDB" id="5919401at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027967">
        <property type="entry name" value="DUF4612"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15389">
        <property type="entry name" value="DUF4612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="189" mass="20763" checksum="71B0849AA017812C" modified="2017-10-25" version="1">MLRCSASIEQKNGNGNNKASKTNNNGAEVNRNEEQNGSLDKSQAKKKPQAPGGGPLLQQTEISTSQLDFFRMLDEKIESSPTQSLKTPPGVSSPTPGSRYQHYHHPDFQQQTQPVKVTKAQYSQGPSPLNGDYYARQGYDSPGPNALIRNSPSNPYVQQFQITSSPQAPVQQLSSATQRKRQPTGFQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6N1</accession>
    <name>A0A232F6N1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenomatous polyposis coli protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenomatous polyposis coli (APC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000791">
        <property type="protein sequence ID" value="OXU26491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F6N1"/>
    <dbReference type="OrthoDB" id="5918429at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000305">
        <property type="entry name" value="Adenomatous polyposis coli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009240">
        <property type="entry name" value="APC_15aa_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026818">
        <property type="entry name" value="Apc_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041257">
        <property type="entry name" value="APC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607">
        <property type="entry name" value="ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607:SF12">
        <property type="entry name" value="APC-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05972">
        <property type="entry name" value="APC_15aa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18797">
        <property type="entry name" value="APC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="506"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="748"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="3">
        <location>
            <begin position="797"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1192"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1273"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1939"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1977"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2089"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2176"/>
            <end position="2316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2445"/>
            <end position="2485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="966"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1220"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1278"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1977"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2181"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2218"/>
            <end position="2231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2242"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2445"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2469"/>
            <end position="2481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2607" mass="286474" checksum="93966E67A4F7B686" modified="2017-10-25" version="1">MTSSPSSLPVSSYEELLEQVRELSNEQLESSDFSFNADDPARVDHSLASIHKNYERDLSEQPPSSRLGIEASQTLPLPPKPLLRLSESSESVTLKIPPGDPTSRLIAWRKKNQHLFPTTAAPALSCTWLFSDGTFPIGSISHGAMIRRRKKRRDKIVIMPSAAGGTMIPVPKSASTLQNHDNAATRLHNRDNNSATSNISKFAKTEKNRLRSLVMQANDEAESEENENEVEDDDDDDEDRDENVTSKDSYGHGKILPRYRANKEGGQQERRRPVSLHGPREDVLFGSNSFGVFNPTCKSSSRPASSLQIESTGPEQSSSSSSSSTQQLQSIPLPQGSIPKGHFSCISVVILVAFVVLLLQLFAKTAQSYQQFDGSSTEEDSRPSSSLQLQCKRSQTSLPSQVSWPAKPDDTWSSTHSSASAGQPIAGSANENDLLSMMSFSSSASGAGSKSPAPGMQGQRRLGAKMDVVYSLLSMLGSTEGREDMSATLLSMSNSVDSCMVMRQSGCLPLLVQLIHAPGQDPETRERASRALYNIVHAKNDEKTSRREARVLRLLEQLRDYCQTLRNSLDSGQPLDDLESHPGATIAALMKLSFDEAHRHAMCQLGGLHAVAELIQMDHTVHGSESDDPNCITLRRYAGMALTNLTFGDGNNKSLLCSFRDFMKALVSQLASPSDDLRQVTASVLRNLSWRADSSSKQTLRQVGAVVGLMKAAMEGRKESTLKSILSALWNLSAHCSTNKMDICAVEGALAFLVDMLTYNAPSKTLAIVENAGGILRNVSSHIAVRDDYRAIVRERGCLQVLLKQLRSPSLTVVSNACGALWNLSARCPQDQRLLWDLGAVPMLRSLIHSKHKMISMGSSAALKNLLSARPNGSNLVHMDSTTRGLGLPTLPSLTARRKSSSVCVAICRQKALEQEIDQNLAETCDNIEPSTSPLSKDEKFTFKIDSTFLDTSNKNLKSFRPAEIPPSVSGQPGPSGLKFSTFSRSESRESMRSVTSTHSDTVFEKVNRQARKAMSPSELQMKQQSASLHSAINFDSGAPADRRSKGLSEKKYTLRYMHAIPERLKPGEPLPDLRRLKCSSSTISWATAPNQDVACSKGLLHSSVEDNLSMTHSCNSANSKVGANPDLNSYSFARAKSTSPFNVVSNSNLPLNNAKITSPIANPFNDIVETDLDQPTDYSLKYLDHTSDDDKQSSAYFTGTDQEQDNVKTSCTEGTPYQSSLNSSRASSASDLLEDGRPRGFCRKSLDSNSTISSNGSKYFTLNTTLTSQNKPQSLISRASSRADSVRSTTSESTLTLEAGRSLESDSAIFEDRKLGESSGVPSLSSLVGVEPKIIDESKPKRINNSRYEAFADGFRDQSVNNLARYATTTKLNDIEIHDFNEDVISGNQTTPLTSLESVDQQELQDEGDRSEMTYTNDYYTVQETYTLEKDFRKAGQNDNDDCSVSQQCSSTLSFVSVDDKESRFDKIVQKDSGELIENLTDQTHTAATSKSGSCESFDSIERSEQALLEICIKSGISKPEALLSSIENGAAVKSPLGRDDIDASKQTVNASSNIDNIYKSGSNTIEVTDRLQDEYRRQRDPDAMIASLDRLTAALVQQTEAMRERESSAMKASLLSDTWNEDSPNEVSFPSISVSAPLVSSFKSDLQEEDRSIPDSMTDSKIIEREAIKLAEAMSAEANKTSLTSLDLDAINPPSTMGSLISLTASIGGVIDNGDNSADKSRAYSSSLPPMQSIGRKKSLPITGVVARRALSHGQNRTSSLENLLNECNSGIISQLENVKPPSIMDELLDLGDMENSMLSVESITSEIADVTKDDNNDSHSLTSSGDPVFDLIKPVANVLSMTCMRYAETMQTSGNNSLSERLENINPPSLFNEVSQMDDSTVDVNTNCSDTLCIDAEFYSEEATHCVFDERIEEIANDTDEAASLFSSDHCSSVESTPKKRLYKNHPGQMTPKQKRQLAKERYKTYTIAAERVKREQEDLKKQEQTNSTSPKIYAGKCSPFSKLTPKQRRQEDRTRFQTQVLEAPVLDKTAHNSLESEPSKIPTPEKNSIQSLVKSGIPTLRKFGSATKTFKFTKSPDHEIKTKAANAQCDEETTEKQEEQSSPTKTTTYSNVQTENMNENRFATYDKRSLANGVSKKYSQVHNDEEEQEEAAGVVASHLISYTVEHTEQNFTIDDKVDLDDSQSESENDSCEKDENQQLKGPRIVKPGTLSRDLSVESDKSEQEVPKGIRGRRKPLYSTPNTRKSTPQSSPLKQTSLVNRSNTSPIVRATRATTLRQNNSLQKSNSPAKNTNTTPATEKRVASANYSAKRSSIPQKMMSTPVKLERQGTFTKDEPEMENAPMVLPMSPCKSNFQTKSETPTLNNNYALTIHSAIVIVIVSKIPAKTSPVHVKSKISMRTPVRSNPSKLTKTASAEKITTPTGIPTIAKRSSTNLGSAVIKSSSNNQIAPTNESGIPRKVSLGQRSNSNSSIISNASNQGTRKMVKEATSKIATLWKKVEENKNKQRFEKPDTRQWITPKRAPTQIDSPQEEKEETCRLFRSSTFEGVTGDSNIPDILEEYNYPYFQFELTQVNSSNLEYIWGSEFLIIKYLPIKASCFLKDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6Y0</accession>
    <name>A0A232F6Y0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Na(+)/K(+)-exchanging ATPase</fullName>
            <ecNumber evidence="20">7.2.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSAR_006877</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Alberta</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.13" evidence="20"/>
    <dbReference type="EMBL" id="NNAY01000819">
        <property type="protein sequence ID" value="OXU26342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6Y0"/>
    <dbReference type="STRING" id="543379.A0A232F6Y0"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="913"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="946"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="65"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OXU26342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="984" mass="109954" checksum="F202D9A1A7E0D764" modified="2017-10-25" version="1">MASKGKASDLATDSRYVRYNSSQSQKPVTLEFAHISIKYKDMSRRKNPKKKGGNLDDLKQELVIDFHKISPEELYQRFQTHPENVSYRASLASPLSRRRGTNDRISLCLQGLSHAKAKENLERDGPNALTPPRQTPEWVKFCKNLFGGFALLLWIGAILCFIAYSIQASTSEDPNDDNLYLGIVLAAVVIVTGIFSYYQESKSSKIMESFKSMVPQFATVIREGEKLTLKAEDLVLGDVVEVKFGDRIPADLRIIESRGFKVDNSSLTGESEPQSRSPEFTNENPLESKNLAFFSTNAVEGTAKGVREVDGDASEAALLKCMELALGDVMGIRRRNKKVCEVPFNSTNKYQVSIHESDDPNDPRHLLVMKGAPERILDRCTTIFIGGKEKVLDEEMKEAFNNAYLELGGLGERVLGFCDFVLPSDKFPVGFKFNSDDPNFPTEGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGTELRELDSSALDDILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMLFLSVILNVCCVRDHHYQVPAISLAYETAESDIMKRKPRDPYHDNLVNERFSLRHSQLVPAISLAYEEAESDIMKRQPRNPFTDKLVNERHKNSWHVTYNRLTRANAGAGHLAGLRSTGIGHYETAASRSLQRQSSEQKIGMIQAAAGFFVYFVIMAENGFLPMHLFGIRKMWDSKAINDLTDSYGQEWTYRDRKTLEFTCHTAFFVSIVIVQWADLIVCKTRRNSIVHQGMRNWALNFGLVFETALAAFLSYTPGMDKGLRMFPLKFVWWLPAIPFMLAIFIYDETRRFYLRRNPGGWLEQETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F719</accession>
    <name>A0A232F719_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000763">
        <property type="protein sequence ID" value="OXU26631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F719"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="396" mass="45731" checksum="0FF5A48F5745910A" modified="2017-10-25" version="1">MSKCTYAQGSRTSIRSPHTNERLNSLSRSQPSRRKSRSPISRQESRTSKSQPERHSTTTHWRSRSNTPLALWPYTKPATVTSHLSQAKSQDKPNPPLQHKSVSAKSQTAPQISPHHSRSYTSRCHSRSQSSRRHSRSQSFRRHSFSKTSWHYSRSQSPCLSLQQLTQSRSSHDKLPLPQPQHDAPSPQLQPDSGSPNSQTSPQKSPHHSRSHTPRHHSRSQTPPLQSQSQTPRRHSRSQTPRDSRSQTPRRPSRPRTPRRHSRSQTSRCQSRSRSRPYSSHHSTPRSHIRDRASHHSRSAGPHHEHPECAVKFLKEFKPKLYRMYKKKGFDLESVIPERYRKYQRLRDDKIYLGCGLSVDLYEDYLKTHKSQPEVNGKSTGSQQEMTESGPEVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7E3</accession>
    <name>A0A232F7E3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000813">
        <property type="protein sequence ID" value="OXU26369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7E3"/>
    <dbReference type="OrthoDB" id="7700758at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="416" mass="47861" checksum="624AB7A66D99C7DA" modified="2017-10-25" version="1">MGDHRAALIKMELPEYEESYGGTSYTICRAIRFVGYVVVLVLLSYSLWRIHVIESTLVDSDRFANVSKIIALGNSNILHRRVARSIKGTNNLIDPNAFEFEKEMARGGMLTSKNETPLPPKKKLRSKEDFNSLVNELFDAIQRMHNDTERSHFDRNMKAVFQAWFPVFDALLPTDLTENNTEETRNTRSVGKSSEESSGENKNKLRIARDVDKSSDESSEEKKDKQRITRDADKSSEESSEEKKDKQDKSRQVRSLMSASDESSEEQTLGENKQKDVTTEAPKKETEKKVENKGERKSSEESSEENNKNRRKRSFDNDSGESAESDSSESHESEKMSQSNAVLDKYNRIHHFDKGYLLVGRRHEQISSESSESLESSEESFMKKKYKNRYDPGFYKIGYRFVTGRPYYVKNDISHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7H1</accession>
    <name>A0A232F7H1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_010715</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000809">
        <property type="protein sequence ID" value="OXU26398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F7H1"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000004">
        <property type="entry name" value="UDP-glucose glycoprotein glucosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="101"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="14">
        <location>
            <begin position="355"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="15">
        <location>
            <begin position="495"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="16">
        <location>
            <begin position="769"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="17">
        <location>
            <begin position="1282"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1551"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1553"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU26398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1577" mass="180230" checksum="02A5151C5C981A66" modified="2017-10-25" version="1" fragment="single">DEDVHHVNADVSEREPVDVSGRSSLFYRYVPLDDGELCFVNGGELAPSKKSRNVDKNHVWVDCMWIFLLLCPLLVNVNSAYAEKKINKYVTTLIDAKWKDTPLVLEVAEYLNDENPNLFWRFVDEVSGRSSDFEKSAKAKDHYDLVISIAEKFLSAAEIAVMKLGLSLRIYSARVEMFSQMAENKEISNLECHNFIDAGGKFTCSVDEIQELMNQEDLVPIDTYSVDHFYLGKQHTDKTLVLYGQMGTDGFTLLHDKLKSLAETNKLNYILRHYVKERPDRRLRLSGYGVELQMKSTEYKATDDSDIKDNEERAEEDTDESDEIDGINFATLKKLYPDEHKKLNDLQTYLLENSHEIGALKVWQFQELSHQAAERIMNSPASEAINVLTDISQNFPMQAKSLIKTKVSNDMKKEMKMNQEIFSGSLNIQPTETALFINGLFFDLEAIDVLTLLESLRTELRVMESLHKIGFGSKKMGKLLALDLSNSVDSRDFAIDIRDSAVIWVNDIENDFRYNRWSPSLTELLRPTFPGMLRNVRRNLYNLVIIIDPLSEESAPLVALAESLYAHSAPLRIGFVFLTNFNMTETGTTDPSIAINNAYHYLNDAKSSKEAMLFLSSLSNYIGPDGLEVNDVKKALKAKDPKANVNYVLGEESEYDVGRHLASDFIKRTGFKKFPQVLLNGVPLPSNQLNADSFEEAVLSTIMSQTPMIQKAVYRGEVTEGDDVVDFLMNQPNVMPRLNERVLKAEKNNWLNLIGSLPTDTDYKKWSSQDISTWLMENLKYLYIPRKTVTNHLYTLWIAADLELPAGRKLMKEALDYLESNTDARGSLIINSESTSKPESNINKIALAAISALPVEKSFDYIRNLINNETFELIQNGEFVIEDEKVKEQLKQQELLISVQQHYAKHILSLSSNGRIVVFNGRILGPFDDDEEFTSEDFALLERFSQSTYGDKLFKYLMKSQLFDDDEYEKSDVTDDMIMKITSLLVPRPQTRSRFDVPFHGDEHSAIKIPAANPDDVAFSLIAVVDPVSRGAQKLGPILNVLRHSLNCDIKVFLNCVDKNSDMPLKSFYRFVLEPELQFTSNGDIVGATAKFTKLPTSSLLTQYIHAPENWLVEVVRSVYDLDNIKLDNVAIGVHSEFELEYLLLEGHCFEALIGNPPRGLQITLGTEKQPVMVDTIVMANLGYFQLKANPGEWLLKLRQGRSAEIYDITSVDGLDVIHKGNNVKVLISSLRSNVLKLKVTKKPDKAGVDLLADDEKGSGIWDSISRTFTNSEEGDEQDEKINIFSLASGHLYERFLKIMMLSVIKHTKSPVKFWFLKNYLSPTLKDFLPHMAKEYGFEYELIQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPLDVKKIIFVDADQVVRADLKELATMDLGGAPYAYTPFCDSRREMDGFRFWKQGYWRNHLQGRSYHISALYVVDLKRFRRVAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKTLPQEWLWCETWCDDNSKKYAKTIDLCNNPMTKEAKLQAAMRILPEWVGYDEEIKALQQKIENENRQTEKEEEHNGPDSDKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Q1</accession>
    <name>A0A232F7Q1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000750">
        <property type="protein sequence ID" value="OXU26695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Q1"/>
    <dbReference type="STRING" id="543379.A0A232F7Q1"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="77813" checksum="E2F49193FDAE8442" modified="2017-10-25" version="1">MDNSRPNVNNNNQSELIATLKISSINVNSMVSLNKRFDLLNYVQANDLDIIMICETKLNNRHRVQFTDYNFIRTDRSAKSKGSGTALLIRNTIPHDIIYPPSSKSNSILEYTIASIKILSKNFVYSLLLHMQTIKTITATTEHSYLPSTYLTLQAFKQLIRSMFKKTKWRKFSNNLSKNNTLEIPQNRNLSINEINQYLDQLEESIINEIQQTVPKYKSTDNVLNYINQKIKKLHKFKSFLITAINNCYRQDRAPSQYDIVFLKHLKNKINISIKNEYKVSYTSYWNSQFKYIDHRNADMFFPKVHRFFLNTPDLRISENKYIIEKPDDILSIIGAFYEKINSSTYYNKHSLTKKTVDNKVNELINAFSNNPSPITTFSDDNPETKPEFIPNTVKFYDILQTNHLFSKLPNKSSSGLDNIPPIKVSCKAPLTLHFFLNIYLQRPTLFNANRTGNSYATAFADDLIILVADKQPSIAQDKLETRNNKRTDIKNFHINISIDNKQIQVDHKRTVRYLGVILDDLLRLNTHIRTQLEKAPPRCKVICYLLLIRPIITYAAPIWWNVSASFMEKIRKFERYCLRASLHIYRESENKHFISNKHIYDVANDPRIDNFIVKLTRDYYENLKKVNNHYLQSYSNTPEHSYIRHRNSEYIPLIYSHFSIQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7U0</accession>
    <name>A0A232F7U0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01000777">
        <property type="protein sequence ID" value="OXU26560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7U0"/>
    <dbReference type="STRING" id="543379.A0A232F7U0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="142" mass="16159" checksum="6F67111C76113B1C" modified="2017-10-25" version="1">MHTCNTNAIKVFVEEIYRSNREVAPAKKEVYSGFRDFLLKPETLRAISDCGFEHPSEVQHKCIPQAVLGMDSLCQAKSGMGKTAVFILASLQHLEFTENKVLALVMCHTRELAFQISKEYERYGKYIPQVKISVFFGELPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F842</accession>
    <name>A0A232F842_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAM234A/B beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000681">
        <property type="protein sequence ID" value="OXU27004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F842"/>
    <dbReference type="OrthoDB" id="6364780at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF29">
        <property type="entry name" value="LD24894P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="7">
        <location>
            <begin position="205"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="581" mass="64017" checksum="8680DD960DEB72CD" modified="2017-10-25" version="1">MSGEPNVKGYAPLPQSISNTDTEDDDEEHQHHREHADSLSKDDDQSRISDTTTICQNGRFYPLDETKNLANRARNGRNPFGYSTDNIPIMILDGQSHDDLWKRHDMSPLRRFCLVASVLLCILTILIFLYVLPCDNSSICPTAPEPKTSVSWDKTLEGVELHGRITVIPGNPYNLIFLLRGQQFGDIDSRESPGQQQITPEGGGVLSMQGISGIPLWWVVLKRLPTDIDCEILDTDGSGKPDCLVSGEGGLLVSIEPIAGTIHWNSEIHAQPSLPLLLSDLDSDGINDLLTIELTNSSQSLVFLSGKSGKVLERQSIPGCQSVELSNIDSAFVLSYTCYNGNSNQSTKTILLKNLIESINFSQARRKLALSGLTQPATSKPPASYPNQTSTDSWDLTPHHRLYVRNVAGDRCPSDVCQTSVNLTLLHARNESRIWDYASASSFVTRPAILDTSGQAYTAGFALKFWNWTADTAAEDKEKSVTPEPTTVRQQSLTERVSIIFVNNTEVHVMNASQSELIQLCRGQDCQPSLPRQAHSIRIADLNGDGVMELISYRTTYNTADDISKATLTSKVQIVKLDAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F857</accession>
    <name>A0A232F857_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000725">
        <property type="protein sequence ID" value="OXU26782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F857"/>
    <dbReference type="STRING" id="543379.A0A232F857"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="335"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="578" mass="63479" checksum="E1FAC87F28310BBE" modified="2017-10-25" version="1">MEDRQSSRQSVDSYVFQPPANKSKTEELGEKMKKIDVKPPSALGLLAKNTALLPSGIVRVKQLRDAALNQASPSSGASSSGSATGNPRNKTALAPGHSLMDWIRLGSSGVDLTGVGGKLLSVAPAELAKHNTENDAWIAIRGIVFNVSRYMSFHPGGVPELMKGVGKDATKLFDDVHAWVNYQSILQKCVVGRLERSAGAELLFESDKSKPKKSTKSETEPVPDPPAAVKMDWRQTTNTVSMFYAATRTDQPLGECRVKKLSDSEFSLRICPAGKSGDIVTHNVKLIEDVEWPPNCQRSSEAPEVEIVFKKKNRGIWKKYGSFAESREKADSTQRSYNEYEVLENTPLCKIVHLLVLRAQNYMQIVPPGRHVEAKMKVLGTEVSRLYTPVPSFIHPEERPATALTDDCLCLMVKRYEDGAMTPSLTALQPGEKLCLSNTLGDFVAEEFDSFAAMHLLAAGTGLTAMLSIVKRALSRRNPPSINLINFNRDEDSIFYGRELDRVSGERTLSVTHVLSAADSSWSGKRGTVSEDLLKDLMGEQSPKACVFACGPPGFMEVARESLRKLGWQASQMREFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8Q5</accession>
    <name>A0A232F8Q5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEST proteolytic signal-containing nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_010611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in cell cycle regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with UHRF2/NIRF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000707">
        <property type="protein sequence ID" value="OXU26870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8Q5"/>
    <dbReference type="STRING" id="543379.A0A232F8Q5"/>
    <dbReference type="OrthoDB" id="10068198at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029169">
        <property type="entry name" value="PCNP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523:SF6">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15473">
        <property type="entry name" value="PCNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="176" mass="20180" checksum="BD58AE759395B2C9" modified="2017-10-25" version="1">MSKKSDYRRDDYDRDYNYRKGSSAYRGEDRDRRREDDDEPRSRDRSPHRPHDRHELSSSSYQPQSGKQKLVFGFDKKPPSNDSKKGGIQMKLGSGSTSKVSKPPPKKHTIASVFNNSDDDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGFCDSKKIFEKTLKKAMEEANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8V8</accession>
    <name>A0A232F8V8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN FNIP1/2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000703">
        <property type="protein sequence ID" value="OXU26899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8V8"/>
    <dbReference type="STRING" id="543379.A0A232F8V8"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028086">
        <property type="entry name" value="FNIP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026156">
        <property type="entry name" value="FNIP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028085">
        <property type="entry name" value="FNIP_mid_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14638">
        <property type="entry name" value="FNIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14637">
        <property type="entry name" value="FNIP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02073">
        <property type="entry name" value="FOLLICULNIP1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FNIP1/2-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1122" mass="124999" checksum="A8D1C0D879BA932A" modified="2017-10-25" version="1">MRMIGEEDEGESAVRNSSNFRADQVRILLFRECEWRGRKLLFDSLAVHRNNRRCSNADNNNETPSYCRRVATKNRRENDATDAATPCEHGKLLSEDVGQLSEMIYGTVAMTYKGPSFKVFYFFLDISSLSSVRIVRAKVKFQIHAMSSPGCVMCTKVFPYSEHSVCRQSERHSNETLGASTNFDSNSSNSSLRTQHSRPGSGNLSGSSLSPTLRKNSTCSSTGSGWDIDVPRLGSSQSLDGSTGLVGGGSLSSLRRRWMRVVSTSLSRSESDDAFGHNYEGSTLDGSEMQLRRHKTRLGLAMLLQLPPGKEQEMSKRLLEHAPLLEGMLDRLRHSCVEAMGIERSLVARLYRASSCCTLRLLRLLMTTEAERLQKPTPLLWHDLLLNSVMPVNMQLSSVYRSLQQMCSLLEELDTKSTNFFLSTIVTAVLTHHLGWVHTAPPHRNRQLIEDFGQQYPFNPLWAQLNDLYGALGTPARIAHTVIAGDPEKVNLIDAVLNFLSYFLRSGLVEKRQETRCTEQEDVAEAVAILERAMRNNPSLGQPSISNYTSVSGKKGGKFAAKKTSKKLEMTNSETAYPLAKSKSYEEPRKGLSTLEAGLTNGDFSSVKVRSDFDIVKKSESFKCEDQSSTKKLKRSSTLQKTLNEYGLSSSATELQASTQPEERQAKSKVKIIVSDENERKLLQKDNELLRTLEKTTGDEEMDQKLDLLRRQKLNGLDLADLDSKTLEEQALLLTYGFADDISREVKSQVYFTLGGEEKPSNNVSIRERLKSSCKCQCSYTFTRVPSTSADLPEGVLRKIIQRNFPESSKNMRPTDSCESDFGICFKCRRGYASSSQGFVNGKLLLETPTNATEVLRGCGSSSSTSNARVLGTNSMEALIEANCVIELPMPRSKKVSPLVKRKPNERVGFVNSLLGSKTVVVDERSSNPSPESGYTWGMVVQGFTKRKKKGRRRIAEETSKESKVTDSGRIKEEEWWWPIREGLGVEAKFPLVDQPVSEALCIVADLDNWQVGLLSNTSAGSTPVPVGMSRLVSNMLEAFTFMWKEFRSPKQCIKLLESRLREMWLRSETLAEYLLAANLDDASVGNLTSFLDVDAADLPLLLAVATTHSPQIAQRFGLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAN9</accession>
    <name>A0A232FAN9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000583">
        <property type="protein sequence ID" value="OXU27550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAN9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14805" checksum="83C51B5BB591449B" modified="2017-10-25" version="1" fragment="single">HRLSTEAVYIRDCLANLHPHLWTRRALVIEHAGLSHQKQDRQCIIGGRLKLDFSVTIILHNTTFNYFSKMSQRIQSNNHFIIYYSICDLDLSSTCTVDPNSIIHYMSSPLFLSVSTLFNILLSQLIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB78</accession>
    <name>A0A232FB78_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000547">
        <property type="protein sequence ID" value="OXU27750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB78"/>
    <dbReference type="STRING" id="543379.A0A232FB78"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="372" mass="42919" checksum="B3327B63B16AA7F8" modified="2017-10-25" version="1">MKGILPYDDYYIWKDAKVGPNGTKLPPNNWLSFFTNSTWEWNEERGQYYYHNYASSQPDLNYRSPKLRQEMQNVLKFWLDRGIDGFRVDAITHLIEDKEWRNEPRSNQNVPPNDYNYLEQLEFMAKILRRALQNPFNFGFVYHLNNDSTALGVGTSVENWIQNMPKDFDDVYRTTIIYNGDEIGMVNRFSSYKETVDPAGCNAGPERYQLKSRDPERTPYQWDDTVSAGFSTNPKTWLPVHDNYKSLNLAAQKNEEVSHFKVFKALSKLKKLPIMTKGYYKTLLIKDNVLAIVRYYPGQDTVVLFINFSDQDEVIIDLWVINPTEETTVVVASVKSGLKTGDLISAKKFVIPGSASVITSSRKLVSSLFSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBH3</accession>
    <name>A0A232FBH3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000537">
        <property type="protein sequence ID" value="OXU27803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBH3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14329" checksum="61EBA04D4A276F18" modified="2017-10-25" version="1" fragment="single">RQAQAEAELDLKECLSAAIASRIASNTIQTESFDVNVKQFSFESDEEIDQYSEALSNEYSNRSSDSDADSIPDSEDEDYMDMDDFNSKYLSEDQVRDKEFREDIVQWSLDFGVNLNAMKKPSAIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC53</accession>
    <name>A0A232FC53_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000461">
        <property type="protein sequence ID" value="OXU28212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC53"/>
    <dbReference type="STRING" id="543379.A0A232FC53"/>
    <dbReference type="OrthoDB" id="7476629at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33297" checksum="7ED6E3657F4467A3" modified="2017-10-25" version="1">METFSTQRFDAKIEGFESCIIDGTGQQQDITQTVSTETTVQDVGTMESEENNEAAAMQQVQNVQQNNQISPLMHQNPQHNVTLTPVRLPAILDGEFFSVMRLEDTNVTARCLQCHKLLNGNLKSTGNFLSHVKRVHPFLMEKIKSKSNQRRPAAIYIDLSQEKCSEIIRVKNRLKKFPKTVIVETFYPTISNINEECHQPIAEETFEQTEWIEPAGLKKRKSEEIDTSEMLRVSHNNSIIVEDEFDAIGRNVAAKLRHMRLDQRIIAEKLLNDILFEAQLGNLHRDSNIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCA1</accession>
    <name>A0A232FCA1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-binding cassette sub-family E member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000480">
        <property type="protein sequence ID" value="OXU28093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCA1"/>
    <dbReference type="STRING" id="543379.A0A232FCA1"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="87"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="350"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68530" checksum="6BF6B9B94624A150" modified="2017-10-25" version="1">MPPKRSTEETDRLTRIAIVNTDKCKPKRCRQECKRSCPVVRMGKLCIEVTPNNKIASISEELCIGCGICVKKCPFEAISIINLPSNLEKETTHRYSKNSFKLHRLPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGRFTDPPDWTEILSHFRGSELQNYFTKILEDDLKALIKPQYVDQIPKAVKGTVQQLLDKKDECNNQVRICELLDLMHIRDRGIEALSGGELQRFACAMVCIQDGDIFMFDEPSSYLDVKQRLNAAVTIRSLIHPDKFIIVVEHDLSVLDYLSDFICCLYGVPGAYGVVTMPFSVREGINIFLDGFVPTENLRFREESLVFKVAESATEEEVKRMSHYEYPAMVKTMGSFQLVVEKGQFTDSEILVLLGENGTGKTTFIRMLAGNLPPDDGSGNIPQLHISYKPQKISPKSQGIVRQLLHEKIRDAYVHPQFITDVMKPLKIDDIIDQEVQNLSGGELQRVALALCLGKPADVYLVDEPSAYLDSEQRLVAAKVIKRFILHAKKTGFVVEHDFIMATYLADRVIVFSGTPSLRTAAHSPQSLLNGMNRFLELLGITFRRDPNNFRPRINKNQSVKDLEQKRAGQYFFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD52</accession>
    <name>A0A232FD52_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin heavy chain-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000439">
        <property type="protein sequence ID" value="OXU28389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD52"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371202" description="Fibroin heavy chain-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1104" mass="100884" checksum="FD6B0034E48141F6" modified="2017-10-25" version="1">MRGSHALLLGLTALACYANVHAEVQDGTLLEDGYHYKKSSSSSNSNSYSQSHEDDLEIDGVVKGQPIKGEKKSGFSTSGASHSESKSFVSGSFSGNAPGLAPGNLLTGVSSALANANAGLQSQVGFGALPNPGTGSLQVQGGGSAGNAISNQISGSSGGAGGSQYWWMAQGSPFKPQGGCNSNGCSISGSFSTGSGGGIVSGGATAGGTAAGGSFSGSLSSTGSIGSTAVSSGNPFLNAVHGGVSGTLGSIGGHFGIGSQTGANAGSSTGSNVQSGAQGGVLGGHGSQGGFGGQFTTGSSGGVSSGSIGSGIIHGGESHGGHFGTGSHGGVNGQGSAQGGSSGQGSISVGVSGQGGSQTTSGGHFGVGTGSHIGSSIAGAVNHAVSQAGSIGGHFGVGSHGGASAGTGAQGGAQGGIQTGHGSQGSGHFGIGSHGSSGFGGTGFGSIGSGIIQGIHGSLSHGGHFGSGSHGSASAGSGAQGGAQGGIQTGHGSQGSGHFGTGSHGSSGSGGTGLGSIGSGIIQGIHGGISHGGHFGTGSHGSASIGAGAQGGAQGGVQGGASGSTETGAQVGITTGYGGQGELSGHFGTGSHGSTGIGSISSGIIQGIHSGITHGGHFGSGSHGSTSVGTGAQGGAQGGAQAGAQGGVQTGQAGAGGHFGTESHGSSGTGSIGSGIIQGIHGGISHGGHFGSGSHGSASAGLEAQGGVQGGAQGGIQTGQTGAGGHFGTGSHGSAGSGSIGSGIIQGIHGGISHGGHFGTGSHGSTSAGAGAQGGAQGGASGSTETGTQGGIQTGHEGQSGLGGHFGTGSHGSTGIGSIGSGIIQGIHGGISHGGHFGSGSHGSASVGAGAQGGAQGSAQGGSQAGVQTGQAGAGGHSGTGSHGTSGSVSIGSGIIQGIHGGITHGGHFGTGSQGSASAGAGAQGGAQGGAQIGHVGQGGIGGHFGSGSHGTSGSGSIGTGIINGGVSHGGHFGTGSHGGIHGGVSFGVGSSADHHIGSHVGSHVGASVGISNGSSTSSNVGTTTDGGYENTQTISGTSETGYPKPQKPQKPFETGHTLSCSGAGKICVAKHKCIHGFVSLPGVSQVNNQEDITTTLISGYDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD54</accession>
    <name>A0A232FD54_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000389">
        <property type="protein sequence ID" value="OXU28734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD54"/>
    <dbReference type="STRING" id="543379.A0A232FD54"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039195">
        <property type="entry name" value="ANKRD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="268" mass="30314" checksum="52204DD7EB067B05" modified="2017-10-25" version="1">MILVLLQNMDERKILEEQLREAACIGDTDAVQELINLGVDVNARHAINGWTPLHWACKRNYLDVVVLLLKSGADRNVKSDKGETPASVSSNPYILQLLGAPYDFSKSSSDQEAPSFVPNYIKHSPLNCKIDLGYPRESYVNTSINTCQEEIILKLRVANSNDSDFIEVDLPRHALSYQNLIKICCDELEINPTQIVKLRKLPNTKIRRDKDVQRLENYQEIEVVLYSSMNMAGEASHKSMQYANGNTVPITPTNNYQSIAKKDQTILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEA6</accession>
    <name>A0A232FEA6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Growth hormone-inducible transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000372">
        <property type="protein sequence ID" value="OXU28818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEA6"/>
    <dbReference type="STRING" id="543379.A0A232FEA6"/>
    <dbReference type="OrthoDB" id="6285520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10431">
        <property type="entry name" value="GHITM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035871">
        <property type="entry name" value="GHITM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="35571" checksum="E6A8BE610189CBB5" modified="2017-10-25" version="1">MMLARVCRGSLVPQTALFKAPVVTKPQLSKIQVVRLYASDGRSAFTRTARRGATISEKVIAPAGETAFNIGKGAVAGGAALGVGALCFYGLGLSSQTGAIDRAGLWPQYVKDRIHTTYMYFGASVATSALSAVACLRSPAMMNLVMRQGWMALVGTMVAMMGTGILCQSIPYQEGFGTKQIAWLVHTGVVGAVLAPLCLLGGSLVLRAAWYTAGVVGGLSAVAVCAPSEKFLNMGGPLAIGLGVVFCSSIGTMFLPPTTAFGAGLHSIALYGGLILFSMFLLYDTQRIIKKAETQPQYHHNTIAPFDPINNAISIYLDTINIFVRILTILAGGGNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEP2</accession>
    <name>A0A232FEP2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000321">
        <property type="protein sequence ID" value="OXU29226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEP2"/>
    <dbReference type="STRING" id="543379.A0A232FEP2"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF72">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER NCKX30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19126" checksum="72551DB6EF9B1461" modified="2017-10-25" version="1">MIDQKTPLFPPDLFSIEERRHGVVILHILGVVYMFVALAIVCDEFFVPSLDVIIEKLDIADDVAGATFMAAGGSAPELFTSVIGVFVSFDDVGIGTIVGSAVFNILFVIGIDNYIYWYEALVLFGFYLSYVTFMKWNRPMEKLVKRVLHHNRVTRVRSTDQLMPAMRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF30</accession>
    <name>A0A232FF30_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_011174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000341">
        <property type="protein sequence ID" value="OXU29068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FF30"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 N-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="11">
        <location>
            <begin position="693"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="12">
        <location>
            <begin position="892"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="10">
        <location>
            <begin position="1136"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU29068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1324" mass="152787" checksum="65E02F45DC824625" modified="2017-10-25" version="1">MTILHHSPTGFSAARCRVQVHIRRVRAHAAAYSQSSLIERKRYRITPRLSLIFSISYFGLLYFGFWIFPVYSKLCIITKKMGVPKFFRFISERYPCINKIIKEHEIPQYDNLYLDMNSIIHTCSHPTDSDVHFRIGKKEFSDEDIFENVSRYVEIIFRIVKPLEMLFLAFDGVAPRAKMNQQRANRFRVARDNSILEREILLTDKLFDANSITPGTVFMADLIDHMKHFIAYKVSTDPLWQKCKIILSGSEAPGEGEHKIMQFIRYHKAQKNYNSNTRHCLYSLDADLIVLGLCTHEPHFSLLREKNTFGKAKKMLAPEESDFHLLHLSLFREYLGYEFAPIKSKLKFEFDLEKIIDDWVLIGFLVGNDFIPQLPHLNIVNGALPLLYSVYIEVLPTLDGYINEAGELNLSRFEKYIKSLSHVEHKIFASTVSSKICNVQEAKKADPIIGDFEQLSIESKKDNAKDLDQEIKKKEYSNFEVQRRDYYLKKLNFKDLSESLILPLVHEYIRAIQWTLNYYYHGCCSWSWYFPYHYAPFIRDVKGLENINLKFEMAKPFLPLQHLLAVLPPANSHLLPKPLRFLLTNSNSPIIHFYPKEFEIDLNDKSNDWEAIVLIPFINEKELISAMDLYITTLNPKERHRNTNGLTCVYTYTKTDLGYYPVDKVFGSFINHAQIERINIADMNVPKNKLVKGLCKHVRFDLSFPGFPTFRHIPHTFGFQMIESKTICNRPIKIEKMMLNVSIKPVPKLEEIAKELLGQKVFINWPYLQEAYVIGVTDFDKKIMLDNFWKNYSEDNLKHAKLSDNSRSSLEEEYFTISDGIYKNGHGIVIGKTEILVYVFPAMGKRYVYGNSGKVQLQTRWSTLSTICPYQLIVKEAKFLSVDPMLYKSITDIFATSDCCFMLGYPNYGSIGQVKSVNFRQQRVVVSLTVTEEPIFTSTEDFFVKNNNDYMSSSIIAKSLSINSTLINRITGSLLVAEDTDKFGELKYHDIGLRIKFPKQQKELFGYSHKKDNFWYYSQKAVQLLQNYTEKFPDLFVNLNKNVSSSTFTVSELFPQESNELNAVKSWLLEQQVLYTTFLECGTKTLGLDGVPKLDKFLCDFRSKQSEPKVVETEVSSQLLFRPGTIVGLIPPDLKAQHKLLDRIICCRANFTVPLGHKGTIIGIQEKQDKWKNVYEVLFDSPFTAGLTLYESFPHKCYRLTIADFVNISFGQRNVSTRPTNEKPKTDIKNAPPPRPNCPNNFRNQPLKNDKEPAVVRNNNAKIKLTGHSTTSVNGNQPPSHTENRPPVTTDNRQNMRPIGRNNNSRNKSSQVKNRPAAASNNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFP2</accession>
    <name>A0A232FFP2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_001069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000305">
        <property type="protein sequence ID" value="OXU29340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FFP2"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000013">
        <property type="entry name" value="IQ motif containing GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000004">
        <property type="entry name" value="IQ motif containing GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="48"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="933"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1640" mass="188400" checksum="E366EAA9CF70FEED" modified="2017-10-25" version="1">MKSTDIEQVIAISNGGVFNVFVIVDKEGRKTAEEMDEIRQKTLAYEYLCHLEEAKKWMEACLREKLPPTTELEENLRNGVYLAKLGHFIAPDILPYKKIYDPEQKRYAVAGLQFRHTDNINYFLQCLKSMQLPFTFQPETTDIYDKKNMPRVIYCIHALSTHLFKLGKAPQIQDLYGKVNFTDDEINAVSKELKKMGIQMPAFQKIGGLLTHSMAGDTAALHAAVIAVNQSLTSKDHMALLPQLQNSTVRLKHINPEYINLYFETLMDAKERKAQAALNRSLNDSYVPDAYDELLTQAEIQGHINNVNMQCAMETLTDCVQQVTNKIALALQNPSLQLQRVSFENNNFYGQELKPLMGSSEWEDRSLENCQYWQKRLQKSIDIANEEAANLNKREEAVKHLNRVLLNGSENDFHEALTDHRLGIFHHIDEFSIPLYYEEMKVDRTESKTDLAYSDIIVSIRVLTAIANVTKCIETNNPDLVYQALTCQDAHVTNLEEVNKVKYCRALTAVYQEKQLTGELCPLLTYIDIQECIDLVNEQCLDDNKVIDVLRYLNQAVKKNSHSDMMDALKQISLKLQIITSPDDASLYLKLFKKCLAEKHSDGSELWLEDVEQITQIVVSEAESVQLACAILSQINNGLERDDFVFTIDCLQSAKLQLSEKHKIQCFKALSQLKKAKQEKYTCPYVRYISPKGNESFIDLKNHYYTWDQPKNLSEPCYITKADVEKIIRNVTLTEVSQYTTKDFETLIVKFQAHIRGYLLRRKIADNINKIIRIQAWWRGLLQRRAYARILESRIKNKASDACKFAKVKSKYQRAIDHFKDHEDIVIKMQALWRGRLARRAFHSLSRLEKPPFSVVRHFSGILNFNAEDYDKDLQLQQIKNEVVQLIKHNQNLSQQLDSMDIKIGLLIQNRITLQDVVAHGKNLENMTKESGSHQIRKNSFSSDTHSAHKGLKSLTKEGRRMLEGYQHLFYALQTNPSYLSKLLFLLPQSKSNKFLHNVILTLFNFGSNSREEYLLLKLFGTALREEIRCKFQKPSEVVTGNPLVLKMAVNYARQLNGNRALREILGPIIEKILADKAITIETNPVDIYKSWRNQLEMETGKALNLPYSVTEQQALQYEQVRIRLSNGIKLLKRTVLELLRRIITSRDLIPYGMLYMSKVLNDTLIEKFPDELEKNILKVVGNLIYYHFINAAIVAPDAFEIITLPIERTLSNDQRRNLASIAKILQFAASKKGFGEEAAHLMCLNPFIIECHEKFKKFFRYCCQIEELDEHFSIHEYTEATLIHKPEISISLQEICDTHCLVLDYQDQIAPDPLDILHELLDDLGNAPTVATLLGITENMNEANIARLGKTEVCLVLSNKFEVPENDDTNLSRLFIKTKELLVSVLQFLRGESLVEALETSTSPVEEKIYNRKNFSSLPKVIVPKSSSLNDCKLQLRAYLNKLELGGWVSQDDGYQKIVTAVAKDLCNKGRYRVLRNKELKMLRDTKQRLEEKSNYYKEQVAYYNEYIKKCLENLNAGKRSLHALKGNEKNGHGKLKSKMTLKYSAAKLQEKGIVLEVDGLPPSQFKNVIFEISPTEQNGLFTVRGKFMGVEMEKVDVDVTKLLELQFEGSPIMDMFGKAKINVNLLLHLLNCKFYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFT0</accession>
    <name>A0A232FFT0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006827</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000298">
        <property type="protein sequence ID" value="OXU29370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FFT0"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1197"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1429"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1458"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1482"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1936"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1990"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2195" mass="254479" checksum="2AAFAC26D2ACF8E5" modified="2017-10-25" version="1">MAQETDEINLTSQELQILSELDSRQFGFLKLNSPEQAKKKALVIRAIKYLERMLVQAQSEKQRRKADSTKTSLEGSKDDDEDEDDEEDKGISIDPKTYCKLGHFHLLLEDYAKAMSAYQKFYELKGDYWKDASFLYGQGLVYFHFNAYQWHHKTVPSSQMHSQAAPNDEAYKTYFEVMFGGCVIRFGWKNYGKSSIRWVVEEKLQVARGSMQKSQLVQLGLVKYFLEYISSKTKICKIIFFINDNVKRDDFHIHEVVKNVMNNISVLLISFDEHHFHDKDYLFNFVNVTKSPTKTLYFLTDSDAKENYMQKTISRLLNSFPSLARSYIVFMLLQDYSIGYLETTLRFAWNNKLLFLTIVELKKPGDCSTNLIVNDYNPFAETFYRECWNPNVLFIREKLDNMHQYPLKVAVINLPPLITLELDPKSNSSFIVKGLEYVLIERLLDVLNFRIIVKPLNLSGGDGTSEIEMIKQLEKGEIDMVGNQLFPLSEMRLSTYTTTTITYDQLCAVVPIIKVSKSEKVHIVALISFILAMVGIISIIKKVLRFDERYWKNIYILGIFFNTSVSNLPKKTYKRIAYAFILIVAFNRTADILKNLTNFRVRAGYELKISTMEDLHNSNLTPLVHPLLKSIAFDLSDRIQASLSEKAKLNKYNDCFENLLDYRNVSCISLKSLQRRIIQNLRSNDIDPHAKILEDCFWSSGKVLYLDPKSPYTKKFNHVILNIKSAGLLKNLKGRNFNYKGKYKDHNLEDESGKDIFVITRIGLMISIIIFLIEILILHQAWKNKILDFTILQLMKDHDCNSMAKVYLINPFLDYFSENCFTRSTVLFPSKLNNMNGYLLNVAMMHIPPITKVRCNFSGNVTCNVEGFQFLILDIIGQFMNFRINIVPVFFNSSGPFIYNVGYFNSENLDKAKIDLVGTHLFPLANPKQFNWPTSVMITFDELRALVPVVCKPIIILKLINIVTTFLYIVAGYIGLHVLKNCLRFDQQYWNLLHLIMVFLNISICRIPKKIHERIVFTLIIVIASVCTSTFINRLIGVRVLMGDEIPLESPEDFAKSNFLLMFDPTFLSKIVDPDDEVFNRLINTKGIRNARNSDCIDKLRKNRDVICIAVGSFANEVINEKSSYINGRPIIKKTKVIFWSGGKNIAFQHRSPYIEEINRILLIIVQSNLQYQVGQQKIISRQNFVKDEFEMKDEELIMQLTFVLVIGYIISIIFFTAYPQLSCSKFLIVTHEMESIRDIQATLHDAWQNKILDLTVLQDRKIDPSCISKAVFHTYNPFFSIYHEHCFRLSSIVFPRKLQDLNRYPINVLIMDFPPITNLKCDYEPNVTCEVEGIEFDIMKILSQTMNFQINVVPAFSNATGPFIYNFGYANDTALRAANVDLRGNHFFPFENDETFHARASTMILFDEICAIVPILHNRYFNINPDKIVFAVIVIISICLLIYVLKHCLNFEKKYWDVFYILITFLNAASLRMPIRNFERILFLLIIILAYFFSSFFVRQLIDFKVSIDNEIPLNTPKDFAESDLSVVFNHIFIPKIVDPDDTFFNHLINKSVSNADDKDCINKLGTKFNTVCITHRTLAESINKKNSIFSGNKTPVFKIAKPCFWSGGLVMALEMKSPYIERINSILLLIAQGNLYHQFQELKSFQEYKYIKDEYEAQDQELLIQLRLLLIGFNTKKTTSRRFWHRFSRFIFYSKDTLYIAIQPKEDKILNFLKIILFSHLHAYPQLYCANFLIVTHEMESIRDIQATLHYAWRNKILDLTVLQDGKIDPTCTSKAVFYTYNPFFSIYQENCLSPGSIIFPRKLKNLNQYPINVLMMHSPPITNVQCSFEPNVTCEVEGVEYDIMKILSETMNFQINVIPAFFNASGPFIPNVGKVNDTTLKAANINMFGNHFFPFENTDSYHGRESAMILFDEICAIVPVLRNRSSGINPNKVVVAVLAIVSLCLYIYVVKHCLNFQKEYWDVFYILMTFFNTASLRMPYRNFERILFLVIIFLASFYSSSFLHQLIDFKVSTDEEIPLNTPKDFAQSDLLLMFDHVYIPKIVDPDDAIFNHLVNLSVSNADDKDCFNQLRTNLNVICITQKSYAESMNKKNNSFFGNEIPVIKVAKPCFWSGGLTMGFELKSPYIEPMNNILLLISQGNLYHQFQEQKSVYEYKYIKEEYEANDIELLTQLRRTLILGYILSICIFITELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFV7</accession>
    <name>A0A232FFV7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000308">
        <property type="protein sequence ID" value="OXU29319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFV7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="154" mass="17661" checksum="9DA033128F8DD600" modified="2017-10-25" version="1">MAGADIVLARRVRDERILKKFAELFGEDSEDDVLYLPIHAPNLKKQKKKQRQPPMIQVKKQDVHPHQPTAPQIQGSGEKIIPVQPAVQKQEDITSQVRASFVVPKQPIANDQLAREVRKMYRSGRSTANYRKRPVYAPVPGQNYRPAVSRKRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGZ7</accession>
    <name>A0A232FGZ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_007152</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000238">
        <property type="protein sequence ID" value="OXU29790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGZ7"/>
    <dbReference type="STRING" id="543379.A0A232FGZ7"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000007">
        <property type="entry name" value="Rhomboid like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017213">
        <property type="entry name" value="Peptidase_S54_rhomboid_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF2">
        <property type="entry name" value="PROTEIN RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037470">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="14">
        <location>
            <begin position="102"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037470-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU29790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="286" mass="31763" checksum="7A03B0C63B480BE9" modified="2017-10-25" version="1">MCISRFEVSEESFNLRAGGLKMAVALLQQQNTPAGANDTRFTSCYLRYLRNKLCISCIRYIVHFTLQLGFFTYYTAAKGEVNSSGPVPIDSVFIYRPDKRLELWRFAFYMFLHAGWLHLLFNLGVQVVVGLPLEMVHGSFRIAAVYMAGVLAGSLGTSVFDTDVYLVGASGGVYALLAAHLANVLLNYNNMEFGIVRLIGIFVIASADVGFAIYDRYAAEQQQLGPPVSYVAHLTGALAGLTIGLLVLKNFEQRLHEQLLWWVALGVYAACTIFAVMYNLMHPDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHM0</accession>
    <name>A0A232FHM0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_017052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000198">
        <property type="protein sequence ID" value="OXU30063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FHM0"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1322" mass="151430" checksum="3667EEAE6D660A6C" modified="2017-10-25" version="1" fragment="single">PLLCDVQRAVARLSRERSPGRRLQPHFTEENNIKSPLLQSARGPMNFMETAMFWIRNIARVERTRCEPLWWTCPGGRPRCWTSTALSWRRLRMTFPTKLCLLTILISLLSYTQPIASLRILGLFPYQMRSHYVMCEELMRGLAAKGHRVDVYSHFPLKKKLPNYHDYSLVGTLPAVSNNVTFEVAAIDSAPVSLKHWLESSGLSICKLLEHPIFQKLLHDPPMDPPYDLVITELCLSNCYIPFGRRLNIPVIGVVTPPLLDWQFDPFGTPINLATDPSIYSSHVAPMSFLERLDNFVLYHRINWAFAQHTREQDKVVERVFGPGLPNSVDLLKEVALVLVNHDLMLSGIRAFAPKVIPVGGLHVVDHNETLPKEVQKWLDDSRDGCVYFSFGSFIRMETFPRHVIEAIYKSFENIAPTRVLLKIAKPQELPPGLPSNVMTQSWFQQMQVLKHKNTKAFVTHGGLMGTQEAIYYGVPLVGVPFLGDQHFNIKAYVNKGIAIKVELQEINEKSFTHALKKILHNPQYKKAAENLSQRSRDRPMNPMDTSIFWVEYIARHGKDALRSPVVDMPWWQASLLDVYAFILVLNWLFLYVLWRLVRIAIGFFRPNAQVRSYSKLKKTNWNNSTCPSSLPRNVAQSSRDTGGLLIAPQFRNWFQCPDNLTFKTDRLKMKFLANNLYLTILISILFYTQPITSLRILGLFPFQMRSHYVMCEELMRGLAAKGHRVDVYSHFPLKQKLPNYHDYSLVGTLPAVSNNVTFEVASIVSGPDMIRHWLESAGIPICRLLDLKMFQKLLHDPPMDPPYDLIVTELAISNCYIAFGRRLNVPVIGIVTPPLLDWQFDSFGTPINLATDPSVFSSYVAPLSFLERLDNFVLYHRMNWAFAQHTREQDEIVERIFGPGLPNCVDLQKDVALVLVNHDSTLSGIRAFAPKVIPVGGLHVVDHNETLPKDVKKWLDESKDGCVYFSFGSFTRIETFPRHILEAFYRSFKNIAPTRVLLKIAKPEMLPPGLPSNVMTQSWFQQIQVLKHKNVKAFVTHGGLMGTQEAIYYGVPLLGIPLFGDQHYNVRAYVKRGIAVKLDLQEVTEESFTQALKQILYNPQYKKAAENLSRKFRDRPMSPMDTSIFWVEYIARHGKDALRSPLVDMPWWQASLLDVYGFILFSVLLVIYIATKFVRIIFERIFGPGLPEYTDLQKEVALVLLNHDSSLSNLRTFPPKVIPVGGLHIVDHNETLPKEVKKWLDESKDGCVYFSFGSFVRIETFPRHIIEAFYRSFKNIAPTRVVLKIAKPEELPPVLPSNVMTQSWFQQIQVLSEFLKLHIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHR4</accession>
    <name>A0A232FHR4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_015422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000174">
        <property type="protein sequence ID" value="OXU30306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHR4"/>
    <dbReference type="STRING" id="543379.A0A232FHR4"/>
    <dbReference type="OrthoDB" id="10249565at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8679" checksum="22ECA94ADFF7FBD8" modified="2017-10-25" version="1">MDLILDINSWLYPMELGDKFRLVLATTLREDGYPDGGDWNAAEMEGGSRANSFEYVMSGKVYRIEGDEANNEPSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIR2</accession>
    <name>A0A232FIR2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000169">
        <property type="protein sequence ID" value="OXU30359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIR2"/>
    <dbReference type="STRING" id="543379.A0A232FIR2"/>
    <dbReference type="OrthoDB" id="10046704at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="193" mass="22414" checksum="4574AC010495C7BD" modified="2017-10-25" version="1" fragment="single">ILSLTTYSPITDSSDHSKNKFKNRHFKNHTNSHVCYKSLDDVQKSAKVHVDRQRNRRSLMSWNYYFVVLLAVLATLLLTADAGDMMRKSIVFDKNTPDVFYCPVHKPTGFDKMIVKAKPLSRLCQFEGGPIPKDYKSDCYNDVDESEYACKEKYRIMMRLHPPGSDTPYNGTRLKKFMTKERNDVPYKKSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJR5</accession>
    <name>A0A232FJR5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000101">
        <property type="protein sequence ID" value="OXU30974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJR5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="507" mass="57793" checksum="EA50B72EFFC521D3" modified="2017-10-25" version="1">MGSFIKVDNASTSIFDHSDDTLNFNDIDKSFVILQKDVESIRASYPDEGMSECDYSAPETDTSAQPSSESGKAYSPLVVHRAFYNKCIRKTIFDQLSIFWSINCSNTENDSREILREKKQLRNERFEKIAMYQKEVLSALHELTRKLDSLKASADEPNNGIDSLVNSSDNSLNRVDTIAQTETMLDDDSEQESKVSRKSFDSIETSMTRTQCVSAEIESVALHGVEADTLSAVGTLCMSTEPEVRTTEIATESIKFQPPITLMPGSSASVEHLANAGLSLSEIEGKKSCILPDSSLTVQHLTERGKKERAFLDKSCEDLNKIMELLDRERIVKKILEKEVLLLRENCTELTRKLEAVKGENDALHMEMNEWSEERERLYESNKLLKCKLESKKEEYEMLKKEIDLLRTKSGTIQVDLDNTKAELAEARRTISELQTQNSDLQKTEISADVYNNLIEKQEIDILRFRATEKSYLYRIELLTDENKLLRNYFDRCLNRCKNIIVSKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK85</accession>
    <name>A0A232FK85_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_002599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8 11">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01000110">
        <property type="protein sequence ID" value="OXU30878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK85"/>
    <dbReference type="SMR" id="A0A232FK85"/>
    <dbReference type="STRING" id="543379.A0A232FK85"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU30878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="348" mass="37757" checksum="F223DCA5CA2E834D" modified="2017-10-25" version="1">MPNIINDIKLDFKDVLLRPKRSTLKSRSDVDLFREITFRNSKRTYRGIPVMASNMDTVGTFEMARALSKHGLFTTMHKYYSVDEWKEFAIQNPDCLQNMAASSGTGNEDFERLLSVLAAVPELSFICIDVANGYSQHFVEYVRKVRLQFPSHTIIAGNVVTGEMVEELILSGADVIKVGIGPGSVCTTRMKTGVGYPQLSAVIECADAAHGLKGHIISDGGCTCPGDIAKAFGAGADFVMAGGMFAGHDECGGDTIEKNGKKFKLFYGMSSSTAMKKHAGGVADYRSSEGKTVEVPYKGGVEATVLDMLGGLRSACTYVGASRLRELPKRATFIRCTQQLNNIYGPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKH9</accession>
    <name>A0A232FKH9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000102">
        <property type="protein sequence ID" value="OXU30968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKH9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="250" mass="27802" checksum="8FB0342E993C26FA" modified="2017-10-25" version="1">MAGIHDHQKTKEHAKPGSSVPPEVPAEERTISPNRRLKIACFLGFTFRAFSVRLHGFQNNTRGKPGRSVPPEVSAEGRTISLNQRLSVGLYNRQLQLRGELSARTKGCKSRFLGVHLSSVLGTFARFLIDQAYIHLKRMEKDAKPGSKHRPEPKAVNSVFLGVHLSGVLGPFARFLFNLASMDLKGTISAENQIGLHLRKFLQRDEISASTKGCKSRFFVNRACVGLEWTEKHAKLDRSVSPAVALLFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLK7</accession>
    <name>A0A232FLK7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DhaK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000041">
        <property type="protein sequence ID" value="OXU31631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLK7"/>
    <dbReference type="STRING" id="543379.A0A232FLK7"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaK" evidence="4">
        <location>
            <begin position="16"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="628" mass="70767" checksum="C88BDA0B184F8FBC" modified="2017-10-25" version="1">MSAYDPLETNRRLWNDPDNILNDSLAATVMMHHDLVYHDDWKAVVRRDCDKLKKTVRIIGGGAVIDGPMYTGFIGRGMLTAAVLGLDGSTTSIPTTDTIVKVVEHCVKNDKEAGVLFLIHDCAEYFLNFLQAKKKAEEIGIPVQIILVRDEINSKLSPKVISSPRSPSGLLLLYKVAGAMSEKGKSLDEIYKTCYEVVKKGSTFSIGVYIVEAVNEPVQIEMARGDRMTDHDMKRFPHCDFSTKKIVENIINESIHVKFTELESNVFIKELTHQLSQYKHKVEPIFTGAFHTSLQSNGFHLSILNLSSHKDLEYYLNAPTLAYYWPKTTKFKDDVKTKRKQSKSSLKTDSSSTNPRSSSSDDDEISEKKRSESPNDSFTEKNIFLKAVEYACESVIACAKKIDMLNKPSTPEDSKRCGTRLATAAESIKTLIGEKEFLEMSLPDMLFRISLVFKQDEQDPQAQLYMNFFTLIYEVIDDRSNSQEHLGVIDWMFAFDTAVFYAVKKVAENTILEDVFRVAREAFDNAYFGSDLNLIDAIGEAALSAQKRTSHFVSNSGKIPKKYMKDKYESSDEIAGAHAVGVWMRGVYEGMKLSYRFHERSSNKRPGSNNRAQVSKSAKYPHDDSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMY3</accession>
    <name>A0A232FMY3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_007841</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000008">
        <property type="protein sequence ID" value="OXU32084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMY3"/>
    <dbReference type="STRING" id="543379.A0A232FMY3"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF21">
        <property type="entry name" value="GH07782P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="130"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU32084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="393" mass="45129" checksum="28458C08E806B1F9" modified="2017-10-25" version="1">MNSAPVRIKDSAMYSSTVTQFEEAPNKVEEDSEPSPLPVKEEGEQPWIWRNIIGIAILHVLAVYSFATRYHEAKLGTWIFNWKKIDFVILPFSRNVNKGGSTAGSKGNFNKEHESSDLDKRPIWGITAGLGITAGAHRLWAHRSYSAKTPLRIFLAILYCMAGMTHFHKWIRDHRTHHKFTETAADPHDANRGFFFSHVGWLMMKRHPAVKKYGSKVDMSDIEADPVIQFFDRYYEPIMMSLTFVIPTLIPVYCWGESWYCAIHSVIIRYVWLLNATFLVNSFAHMWGNRPYNSNVKPTENATVSFFTLGEGWHNYHHSFPWDYKAAELPGYGLNASTGFIQAMAWLGLAYDLKTPSKELIEKVSVNKGDGTASKWGNDHHRRQREQQKVKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNA8</accession>
    <name>A0A232FNA8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pro-resilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000010">
        <property type="protein sequence ID" value="OXU32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNA8"/>
    <dbReference type="STRING" id="543379.A0A232FNA8"/>
    <dbReference type="OrthoDB" id="7701623at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012986019" description="Pro-resilin" evidence="4">
        <location>
            <begin position="34"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48926" checksum="086021B0484FACA6" modified="2017-10-25" version="1">MHCSERSIIERTKGHSLPYLALLLVLLPPLVVSRVSKQRPVNEASMVEKLAQSGRGLMIDSSLIAQPEEQPAVDYKPRLPRSPAVAHQQSTNTAAAKRDLHYKQLRRARGARDSYRTMIVRDVNALNEKRAQGSFLPGQINGLNEESLVPDAKNSRAFLPPKIVYGETSQLPAPFVRAGQQERGRAFALANFLLKNREPMSPRSFGFQKDAKDRDREQHNGMEYILEKSLFSSENNDETNERPSLSCPFPTAEETSSSEKLTDQSVLTPLTTKVINDEAMNEGYALFHRIVEEGADSSQIFDVNSVADEDEDVEVAPKAEASSKYEEYDSDAGETFDRFKDDARSEQQTTINECPSRRTQDSRYEFGYRVIDHGAGSDFGHEESHRVPGETNGRYHVLLPDGRVQRVEYYADDTGYHAEISYARSDDQEPHQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNH7</accession>
    <name>A0A232FNH7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000002">
        <property type="protein sequence ID" value="OXU32291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNH7"/>
    <dbReference type="STRING" id="543379.A0A232FNH7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU32291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="777" mass="87131" checksum="F4D213B841605E90" modified="2017-10-25" version="1">MYLEAICIIELLRDSCEVAKLRDESTVNFEPCIGRTYDRYYTNISPLAVVDMKCSRCVYIDTSSIVLISAVSMPAPSINADVARLEYLLSRHLQPFVQFELNSYGADKTLALHLALRLKDDNDNNNNNERENKIELVKLLLKSGASAKQKLGKNGETALHVAVKHCTEPVILRQLLDAGVMLNATTRHEKLTALHIAVKTNDRLAVEEMLNRGVRIDAQSRVGDTALHLAVKFEFKALVQLLLDHGADPNCQNDIGETPFTSSLGRVKDRISNLMLSETAVKPVNVRLKNHAGETALHFATLRCYSVTVFKTLLNLSHLNLKNDWILLFHVIKNPNSSIRMQLFRALLKHGTDLRRFVNKDGQTLLCLAVHFGSVDVAKYLLESEKVDVNGKPGRKVPLFGALRNGNEVAVNLLLRHDARVDLIDRHVCDQSSVHAAILGFDDKAASRVCKRLLDYGAPLDHLDSNKNTALIRALRNCRERVASLLIARGANVHLKNLDGLSPLHIASNKGLIDTVKKLLDAGANVNEVTNMGSSVLEYATYSDSEEAVKLILEHGANCRTDSRALLSALAFHQKNPQITKLLLAHGADINLKIQDKLPLAHTIHNYKYSSSSSLVLGYLLKHIALLDSQGQPVQQENLELIDQYEDMKNFYEKSVRQLEIMRSTRVCQKSPVTYFDLLTKRHDGLVRCLRCKKLTLAVRSNADKSTFPFYFNDMLSNYNVGLRRLSMLQKLQVLLQDVLGNQLPCELIKILCQYFNDKELEAYRIEPNNNNADAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNL6</accession>
    <name>A0A232FNL6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNL6"/>
    <dbReference type="STRING" id="543379.A0A232FNL6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF8">
        <property type="entry name" value="ANKYRIN REPEAT AND KH DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU32163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="375" mass="41484" checksum="5258FEE82384923C" modified="2017-10-25" version="1">MAGAPCPMHRVGYLNFCHAFSYNQCFAFTQAYACETGKTWNYTEGEFRGKTCLETAGVLVHDVRRNTAISDPMHLDTIHGIVLYSVCTTRTPPEQVLQGQTDDSGKFMNSPFRSKKVAVPPNAISRVIGRGGSNINTIRAATGAHIEVEKQTRENLLRETRDDDDHGDEEDRQIYTVLSSSDDSDGDTIRRWVPLRSAKRRLSYDLDDDDGDDDGAGTSVPRSCQRVSGPSALVPYTDEDTATSACATSVTATERLNDGHQVEILSGFTMLESSGEDVKASNRTFIGRSYPRGDLVRVIHRNYDVLNEAVQCAIDARSVSESSDEDDEDLPIAQLQQQQRQPLQTMLSVQQYKTFTCGQSQRPSVLIIRSSIAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDD1</accession>
    <name>A0A232EDD1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006954">
        <property type="protein sequence ID" value="OXU16345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDD1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="207" mass="23061" checksum="7520F3F3CB429C56" modified="2017-10-25" version="1">MALGVNGNTSDYIWKIEAGRDRTVRGALSEWSTGNYQILCDAMSNECTLIGLDFSLQISQENIKRSRNGAFLGYSSSGNEKYANLCQNCSRAVHYANTVTILYQSVPIFCQSVTNCAGHMANCASIVPNCAINVSNVQNVHVFVQLCHNFDTDWHSLAQIWHSFGTVWHTHRFHLMFLLSKSTEKHACQMNRAVTLHSNWPVGLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDE8</accession>
    <name>A0A232EDE8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_013303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006779">
        <property type="protein sequence ID" value="OXU16358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDE8"/>
    <dbReference type="STRING" id="543379.A0A232EDE8"/>
    <dbReference type="OrthoDB" id="8195605at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU16358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="258" mass="29316" checksum="5102945EA5DA7898" modified="2017-10-25" version="1">MVRSYKKKSDRLSWSQDQMLSAVDLIVKEGKCLKNVASQFGVPRSTLQRKVNIVNKNPSTGPDNIFKGFTCTFNAEQEGAFSRKITRMENMLIPLTSIDMRKLAFQFAEKLQIPHHFSKETGFAGKDWLRGFMRRHELSLRKAEHTSAARANGFNKEAVQEFFSLLQDTLKRYNFTPERIYNVDETGISVVPKTSPKVIARKGKRQVGGKTVAERGETVTADLCMSAGGAFMLPMLIYSSGQQRFKFFSSTKLYLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDQ1</accession>
    <name>A0A232EDQ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006059">
        <property type="protein sequence ID" value="OXU16464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EDQ1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="140"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="324"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="866" mass="100464" checksum="79421BC42999BFBA" modified="2017-10-25" version="1" fragment="single">MQNSLNLLDCLLLNLCIFMRLAAVLNFLASGKSVPQSSWFFRIGRSTFYKMIPEVCEAISSSLQDYCVFPEDPEDWLRIADGYWNLFHFPNCLGAIDGKHCRIKCPANSGSWFYNYKKFYSILTFSYKMDKELAAQVDEYIISEVEERPDIYNAKDIFASSDRRQLFFEGLTLHLKTLFNVEWKVEKTKQRWAKIRTTFVDASRNKSKKIKCWPQQNFIFNRCYYFLYDYMNHRTVNKTHMGXSSSLQDYCVFPEDPEDWLRIADGYWNLFHFPNCLGAIDGKHCRIKCPANSGSWFYNYKKFYSILTFSYKMDKELAAQVDEYIISEVEERPDIYNAKDIFASSDRRQLFFEGLTLHLKTLFNVEWKVEKTKQRWAKIRTTFVDASRNKSKKIKCWPQQNFIFNRCYYFLYDYMNHRTVNKVQLDSSKFPLPDTYGIEFPVEDEGALLMRKEESDDLDHQFPDVNCIFNNNDDAGAVSHPATPEQHPTQSPVEKTKQRWAKIRTTFVDASRNKSKKIKCSPQQNFIFNRCYNFLYDYINHRTVNKVQEESDDLDDQFPDVNFIFNNTDDAGAVSHPAIPEEHPTQSPVEKTKQRWAKIRTTFVDASRNKSKKIKCWPQQNFIFNRCYYFLYDYMNHRTVNKVQLDSSKFPLPDTYGIEFPVEDEGALLMRKEESDDLDHQFPDVNCIFNNNDDAGAVSHPATPEQHPTQSPVQEESDDLDHQFPDVNCIFNNNDDAGAVSHPATPEQHPTQSPALFPNATDLLNKPDNGHALTNGCNNHGNVLVETGIATDKDYTTVMCTYVDRSKCIKPSATCPAFGTLALRSSVTNKVGEKSTSFKMPGSTRGTSEDIRRSKEQVLDQVIIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-05-29" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDV4</accession>
    <name>A0A232EDV4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005911">
        <property type="protein sequence ID" value="OXU16523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDV4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="9007" checksum="ABD1590864696D8F" modified="2017-10-25" version="1" fragment="single">ISSFAVYYSRKNNVRLSRWHLPFSHIVCPIAYKKLGLDRMPLKLQEFDFLIVKCPTSCRITHIQSLQHLKCFNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EER1</accession>
    <name>A0A232EER1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005243">
        <property type="protein sequence ID" value="OXU16837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EER1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="193" mass="22255" checksum="35FB31F78B7A6FE4" modified="2017-10-25" version="1">MFSMAIRQVRANFGPYRKGTANSEALQHFTFGLRFPLDYQVRSNHPIPLGEAIRLAIEYEVIYNLHVKEKGFCNYCGRIGHTVDFCRSKKYQLNNGRNNNNPNTNNGGRNDNNNQNGRFNNGNRRPNNHNNYGNQDNEGDNRNNNKNNGYIDRNSDFTNNNAPCYEGNNNNANNIDGPNDRRPKEQYKNNHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHP8</accession>
    <name>A0A232EHP8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004460">
        <property type="protein sequence ID" value="OXU17864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHP8"/>
    <dbReference type="OrthoDB" id="7682106at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="13811" checksum="D614A624B2E8AC16" modified="2017-10-25" version="1">MAESSEEVEIKIEIQKLLGQINNDMIKLKTELNTINNLIKENASLPTTMKMVNEKLIITAKDAGIDIENLDEIVSLRDLEEDEDGARGGSDTVQSNDNASKQTSDVSDFSAATHKITERIKHALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI65</accession>
    <name>A0A232EI65_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004327">
        <property type="protein sequence ID" value="OXU18046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI65"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="9946" checksum="7C5B8A6BE7B62BE0" modified="2017-10-25" version="1">MNACLNQTIKIANQRNVEVVDTPKYSLARTTLRSLPSRGFQRLLHEKRGFDFPAARKKQLGRRFDPCGPAGERSNIRSKQYKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI87</accession>
    <name>A0A232EI87_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004304">
        <property type="protein sequence ID" value="OXU18079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI87"/>
    <dbReference type="STRING" id="543379.A0A232EI87"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="14247" checksum="8F5E8D02E42E7B5A" modified="2017-10-25" version="1">MPCVLTCSQWREQQMKEKAEKERKALEAQQKALQRKIKKVEKEKQQQILREERERKRAERIKIKEEKIKIKEEKIKNKIENNNVKKQKCIQNAVRVGPLQAIDTNIQENIVPLDLSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI90</accession>
    <name>A0A232EI90_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004320">
        <property type="protein sequence ID" value="OXU18054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI90"/>
    <dbReference type="OrthoDB" id="7542660at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167127" description="SMB domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8723" checksum="019DB304D88F0AFD" modified="2017-10-25" version="1">MSKVLVLLLAIILTSTLAVARNSCSPWLGYCQVYEDCCRDLECSSYAGKCVPVNGLKIPGKDQRPTGPGPFPPSVMYRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIA7</accession>
    <name>A0A232EIA7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_000512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01004299">
        <property type="protein sequence ID" value="OXU18086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIA7"/>
    <dbReference type="STRING" id="543379.A0A232EIA7"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000108">
        <property type="entry name" value="Ethanolamine-phosphate cytidylyltransferase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="204"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU18086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="364" mass="41359" checksum="0E011F0339A8E547" modified="2017-10-25" version="1">MSEGRKEVRVWCDGCYDMVHFGHANSLRQAKALGDYLVVGVHTDEEITKHKGPPVFTQEERYKMVRGIKWVDEVVEGAPYVTTLETLDKYNCDFCVHGDDITMTADGVDTYHLVKAAGRYREVQRTAGVSTTDLVGRMLLMTRQHFRQGESEYSVDREPSKSMGQDRTARSPWTGCSQFLPTTQKIIQFSDGKSPQPGDKVVYVAGAFDLFHVGHLDFLEVAKKEGDYLIVGLHTDPAVNRYKCGNYPIMNLHERVLSVLACKYVNEVVIGAPYEVTKELMEHFNVSIVCHGQTPIMPSEYGTDPYTEPKRQNKFKTLDSGNDMTTEKIVERIILHRLQFEDRNLKKEKKELAAYEAFVKGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIQ9</accession>
    <name>A0A232EIQ9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004208">
        <property type="protein sequence ID" value="OXU18198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIQ9"/>
    <dbReference type="OrthoDB" id="8190250at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF23">
        <property type="entry name" value="IP06949P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257625" evidence="3">
        <location>
            <begin position="24"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="264" mass="28442" checksum="9DF1E76E8F6EA787" modified="2017-10-25" version="1">MRPSRLLLVLAILLVIENDGVVGQSNDTVWKGFSVTCNNDDKGEVTNVSVSCHGIRLVRKIVQKLLEEANRKRSLEILDGVSLVQKDEEEGFNRGARVLKESGQTSPVMSFLENRELRIKLPSFLPANLEDAIEGSLPSADQAKGRGGGGGGGGGGFGGGKGGNGMMMMALMMGKTMAAMGFGALTLLAMKALMVSSLALMLSLIVAAKKLASSKEDDSHHVVYAQEVSSHHRRRRSLGSKQDDLKNQPYRGYINLPTEMQKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ95</accession>
    <name>A0A232EJ95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004060">
        <property type="protein sequence ID" value="OXU18425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ95"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="203" mass="23427" checksum="E9EC9A67CB78AC19" modified="2017-10-25" version="1">MTTVSGFLANEEPECGASNTSSENSEPLGIPVSVFEAFDDFAYVPRQAEREQVTESTTPDTSVSYLRRFRSNKTMDYWHITTNQTHDYIHLHSVGRHFTPYIRTESDTLPDLENSEPKESYNETAEIPEHSFRYKENIFFLLTTDIFLETEILDATLERGYTTENILRSTERNLGDVFITDFNGMKLFGLFIESHINEKQLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJI3</accession>
    <name>A0A232EJI3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004032">
        <property type="protein sequence ID" value="OXU18471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJI3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="7893" checksum="E26726193C6B01E8" modified="2017-10-25" version="1" fragment="single">QVNDVVRDRERASERKRIRELTLTVGSSRSLSGMLESRTSPSQASRRSRRLDRVKTMSHEEASKVIVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJP1</accession>
    <name>A0A232EJP1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_003451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003989">
        <property type="protein sequence ID" value="OXU18528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJP1"/>
    <dbReference type="STRING" id="543379.A0A232EJP1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="89"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="466"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU18528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="748" mass="86781" checksum="9AF94FB8853ACC3D" modified="2017-10-25" version="1">MPPNASSANPRIQDECDEAHLECPKELQAKIVAETRAINKKLNIAEKVSKDKGWLDFETELIWPNIVGITLLHILGVYYFFAFPYLQHWKSFLWGYLVGIMGGFGVTGGAHRYWTHKTYKANLPFRILLMICYCISGQNTLYDWVRDHRVHHKFSETDADPHNSNRGFFFAHVGWLMMRKHPEVIRKGREVDMSDVLADPVVAFAQKYFVPLKLLFAFVIPVLVPVYFWDESLRIAIVSQWFVRYMLLLNFTWSVNSAAHLWGNKPYDKNISPVENRIVAFLSMGEGWHNYHHVFPWDYKAAELGDYNLNGTTAVIDFFAWLGWVWDRKQPSADLVETRGGSRRGREEGDESSRWRETETALQLVATISADNESNYTRSRFCMHARAAVCTMAPNITSVPTGVLFEDEMVENLHTSQHPSKEQQKNDKVYKLQIVWRNVIIFVFLHIGALYGVYLAITSAKIVTTLFAFLLYQLSGFGITAGAHRLWAHRSYKATWQLRLLLCIFNTLAFQDSAIDWARDHRMHHKYSETDADPHNATRGFFFAHVGWLLCRKHPEIKRKGPTLDLSDLKSDPILAFQKKYYLYLMPLVCFVIPTVIPVYFWNETWTNAYFIPTILRYAFTLNMTWLVNSAAHMFGTKPYDKSINPVQNKGVAIMALGEGWHNYHHVFPWDYKTAELGNYTYNFTTAFIDFFSRIGWAYDLKTVSMDVVQKRVQRTGDGTHELWGWGDKDQTQEERDQAIILNHAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJX9</accession>
    <name>A0A232EJX9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003942">
        <property type="protein sequence ID" value="OXU18611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJX9"/>
    <dbReference type="STRING" id="543379.A0A232EJX9"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU18611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10933" checksum="AF359D0B1394D6A2" modified="2017-10-25" version="1">MPADQIQYSEKYTDDKYEYRHVILPPDIGKQVPKSHLMTESEWRNLGVQQSPGWVHYMMHGPEPHILLFRRPRSDLPVRNNINQQHQNICVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK38</accession>
    <name>A0A232EK38_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003902">
        <property type="protein sequence ID" value="OXU18688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK38"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="178" mass="20170" checksum="29512D359CC7ED77" modified="2017-10-25" version="1" fragment="single">VFEVAEHEYRNNTLRGAWCLGWAVSTSSPRVSRKINDKFRQDSFSRSQNTNIVTTTHSEVPGAQGGQYQRRLLEFHGKLTTYFVESLNSGVFEVAEYEYRNGNTLLGTWCPRWPVSTSSPGVSQKINNTFRRDSLIRGFRGCWTRMSDDDALRGISRATEHGYGVLLKIILGNDVDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELB7</accession>
    <name>A0A232ELB7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003589">
        <property type="protein sequence ID" value="OXU19145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELB7"/>
    <dbReference type="STRING" id="543379.A0A232ELB7"/>
    <dbReference type="OrthoDB" id="10034606at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF76">
        <property type="entry name" value="FI20010P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="776"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="929" mass="106733" checksum="37ABA8A9E708C28F" modified="2017-10-25" version="1">MDLNELTNVEPLVSTILDKNHLSKDIPVLLHEPSYSKNLSSTDIIEFDPRQTNFEYSDCRESLHSINEPSTSKLISWTNASSNNDASVCNRASTDLKTNISIYENFEQGSFKNTEENNNQLISKSTVIDINYKPESEQFETHNANAKKEESDMVDTQFSFATQDTFENLFASNIKATVESLPVFEEYDKTNNSSLNISDDVKEVRSNIEKCNETSNLSIGTSNNNLLCSREVSNNINKENDDDSIMQKILDLANVYMNVTFKAMLTELYSKKYSEHIPSTVLREINFLVSVNNESKMKDVTPTNKEVVNTGPKFLTSEDIGSKFLVKIYDCKSITEIWGKIMNATNLKKLDELLEEMKKFYDSEKMVASSIKEGGFYAVYKDDFWHRVKCLKCDESTALVFFIDQGDEYTFLLENIFELHDKFVLIPAQAIKMSLSDLEDISDCYEAFIILKDKLLEKTVYATMLQYKDNCCNVKLYLKIYEENINIADLVIEQLSKTFLNPKISIQTEELMPVHVSSINERSIFVQLIESKSYTYFMKLLKNVVTKYLGDENIKHELQLNKNKMYLVKSPKTEKWYRAKILNYKSENQVELSLIDTGKKISIKQGNLFPLEKFSSILTKYPEQAIEVQVHELSSFYELETLKHFRKLMKSINTFLASFVIRTLSDNIPTIRLLKKESDGSLTPINDELLFNQIFQNGSTIAVPLKKSESSDNIITLQQNMSKMQELLRSALSLLSLSTVLDPPQIPNDFLDVHKLECQLSDACNSYKGPLLTVDSVKIGQLYAAKYNEYDKKWYRVYVCQLMTDTKSANVYYCDYGYYKEVKIENIVPLVTQFRQLPYQAVWAELYGIKPIFERWTIDDASRFKDLVHLKKLVGINRGKKSFKPTSYVALTPITVETVYSLELVDTSTADDIYIADILVNEKRALKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELF9</accession>
    <name>A0A232ELF9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003560">
        <property type="protein sequence ID" value="OXU19199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELF9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20254" checksum="383E6C999B5C6E76" modified="2017-10-25" version="1">MYSREVDIQKENANNSNNKDSTSKPMPISRTAFYDITTPKVFYTEFKWTLQNCRMLFYLDQKVFRSCGFTLTGSNQTCFLSLNVSNKDFNSYLHVNLEACKRKSLKMIVNVSIVKKNGEKVRTLSKITNVKDTKDSLCFAMPSLTDLRDTDDYLVDNTLTFFCEIEDVQDVCNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELI1</accession>
    <name>A0A232ELI1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bee-milk protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003548">
        <property type="protein sequence ID" value="OXU19219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELI1"/>
    <dbReference type="STRING" id="543379.A0A232ELI1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012963522" description="Bee-milk protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35711" checksum="EC103FD9211D4C65" modified="2017-10-25" version="1">MILFVLSSFLILQAAPAAPVNENEAELLVAAKYGIYRMNLDGSKAVLVSDAVDARSVDYHHAKHLLFWSDVATHKIYSKDLFNESSEIKTVVAGPNDWEPRAIAVDYVNDKIYAIDQSGSKIDVFELDGSKRISGINVNLTKPVEDDDYTMDIVVDPNEGLVFYGEYNKVMRATMDFASVKYVGHKSFISGLTIDREAKRFYYADTQRFLWKTNYDGLREDHVNAYDHPTDYVRGTAVSPRSLSKYDGGFFWVNGRADGVHHLQRYSSKPVNTKVKNAFTVRGSAKGCEKADCKYMCLVSNPTYSNLTHSCFEEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELP1</accession>
    <name>A0A232ELP1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001542</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003522">
        <property type="protein sequence ID" value="OXU19267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELP1"/>
    <dbReference type="STRING" id="543379.A0A232ELP1"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="177"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="400" mass="45330" checksum="257D00E806332C5A" modified="2017-10-25" version="1">MAATVDAVREKALQDYRKKLLEHKEVESRLKEMRDHLKDLTKQYDKSENDLKALQSVGQIVGEVLKQLTEEKCIKQVIPLIVKATNGPRYVVGCRRQLDKNKLKSGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGDVTYSEIGGLSEQIRELREVIELPLLNPELFQRVGITPPKGCLLYGPPGTGKTLLARAVASQLDANFLKVVSSAIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDSLGQVKMIMATNRPDTLDPALLRPGRLDRKIEIPLPNEQARLEILKIHANPIAKHGEIDYEAVVKLSDGFNGADLRNVCTEAGLFAIRLEREYVIQEDFMKAVRKVSDNKKLESKLDYKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM91</accession>
    <name>A0A232EM91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003399">
        <property type="protein sequence ID" value="OXU19474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM91"/>
    <dbReference type="STRING" id="543379.A0A232EM91"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF36">
        <property type="entry name" value="NIEMANN-PICK TYPE C-2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511524" description="MD-2-related lipid-recognition domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="16663" checksum="AC28C283BAB25483" modified="2017-10-25" version="1">MKLITGYIIAAFLVAFSTQSTPVQNCKDAPAPKDVRFDGCSEPPCLLVRGTNATAEWDFSIPEDTNVLKPRVLATYLGETVLYPFPQENACDTLKNAKCPLKSGQDVTYQLSMPILEYYPRIPVSVEFAFLDDKDKLILCFAFSAKVVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMH7</accession>
    <name>A0A232EMH7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003353">
        <property type="protein sequence ID" value="OXU19560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMH7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="29" mass="3367" checksum="FA29355E7B3CF0AB" modified="2017-10-25" version="1">MNCVTWIIAKKIIELDYIVTNIVTEVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN57</accession>
    <name>A0A232EN57_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003217">
        <property type="protein sequence ID" value="OXU19780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN57"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="898" mass="102132" checksum="D6228591D0732185" modified="2017-10-25" version="1">MIAIVAQVKDEDFFNLSIEAIVGILKQNMNDVSLFLPLYRTEKENYLKAQNAILNNASIDLNMSWTEDNTLSEIPIELVSTLPSDANDASVNDEDEIDFGDISTSKEVKISTHNISDEFQFVENSLYFSLKDTIEGRIILGAYKHSKTLLQKRLKIIVIQKLIVENSVSYKITKARFLEIRNQIVELFPTTTPADWYQEHHANVHGQNVSASGCLVNYYKIYRQNLALAGIIKGKVTSDASNIGIGGEVVSAESEFKALIYVNRSDYTVRTVLDTWSETFEKRQEILVVRKNKKITIRYESYINTFVCLQSTFGLELLQSDCYSIIKGLSETNAIPRSVADNFKNLFKTRWVSLAPLICLHGDASQINCIKEFKKTHKDYIGEIPKTILALFYAAYFLTKTYSISSKDKGTFILNTLGLPAAPYVVFCGQLNNITNAFVVIDNIHYEVRDPLRAVEHCLQAAVALHSWSTTTANVWLYILEHVYSIRPNISYSFLPAKATKTISTFIKKIDPSFSTAEIPRLALIIINNVKKLSVESNVICNVMQGKFWKKNVINDAINTYILPLFVYYDDIEVELNFLRDTGITITVDNVLTVFKFQTVLIVGDNLGLNAIYGMVESFKANCYCRICTADSFECSQLCTENKKLLRTQENYCSDVMRGKTNETGLKEQCVFNQLSNYHFVVNKSVDFMHDVLEGVCIYVIRAILNELIFESKLFTLEYLNLRIKEFVSYSDDTNQPPPIALNRLKGKLNLKFSAAEMLYLTRYLGVIIGDKIPRDNEHWKISNDLYSKVTVNGSEYKIGSVIVVSVEEPDFRFGEIIEIKKLLSTYGTKDGVDKTESKVQFTVVIYEETYFDNHFMVYVVEKTGENKIVNCDNIPSMPPVVALKKNQNHCIIPRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN66</accession>
    <name>A0A232EN66_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium channel flower</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSAR_009199</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Alberta</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="19">Homomultimer. Associates with the dally/ magu complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the calcium channel flower family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003207">
        <property type="protein sequence ID" value="OXU19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN66"/>
    <dbReference type="OrthoDB" id="9934994at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXU19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="23770" checksum="A86AD1A0E86411CB" modified="2017-10-25" version="1">MVSIIILFPRWKPNFELFIAKLVVFPRLPRTQSFSEKFASIMARPGQDPQAKDDVPWWMKYGGRILGIVGGFLAIFLGVWNCVSILLANVSCFLSGLTQMIAGFIVLTIEAPCCCMFIDFVQNFSEWVDKRPYWNRAAAYCLMAIPPFLLCIGATSFFGSGLIFATGVVYGMMSIGKKGSGADPTGLPTSAVGSPQGQMPPGDHHTTLMEDPDGINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENH0</accession>
    <name>A0A232ENH0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003150">
        <property type="protein sequence ID" value="OXU19905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENH0"/>
    <dbReference type="STRING" id="543379.A0A232ENH0"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU19905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="511" mass="56546" checksum="CC2D2C1D6FC510B7" modified="2017-10-25" version="1">MVECFNSLRVDGAYRHEQEMRRRRNEVTVELRKNKREETLQKKRNVPVTDSTDEDDIDKQLAKTNLQELVLKAASTDPVEQLQAVQSARKLLSSDRNPPIDPLIASGILPILVGCLEQHDNPSLQFEAAWALTNIASGTSAQTNAVVQAGAVPLFLHLLLSSQQNVCEQAVWALGNIIGDGPALRDYVIQLGVVPPLLTFIKPDIPLTFLRNVTWVIVNLCRNKDPPPPVQTIQEILPALNVLIHHMDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPRLIPLLSHKEVKVQTAALRAVGNIVTGTDEQTQTVLNCDALSHFPNLLTHPKEKICKEAVWFLSNVTAGNQQQVQAVIDAKLLPLIIRNLSKGEFQTQKEAAWAISNLTISGNKEQVARLIEEGVVSPFCDLLSCKDSQVVQVVLDGIHNMLKLAGPQVEVLANMIEECGGLDKIEALQGHENVDIYKLAYDIIEQYFSDEVDDVNLVPPVVEEAFEFDPSTNMPSEGFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENJ6</accession>
    <name>A0A232ENJ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L3, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_006006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003150">
        <property type="protein sequence ID" value="OXU19901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENJ6"/>
    <dbReference type="STRING" id="543379.A0A232ENJ6"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000049">
        <property type="entry name" value="39S ribosomal protein L3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="379" mass="43230" checksum="E6044E8876376CEA" modified="2017-10-25" version="1">MTTLLKVCNGLQPLKGFLQPTLETFTLPNRGKKLLNPYPRKKFPPWFVKQTRVVCKDQHEEDLTKENKEFIRTVIRDKYPLPDIGFGSASPLKLETIEPVTEWKPHYQRVGVIARKIGIVPMWMKDGKKVLTTMFQVADNHVIKYIPPEEYKPMITQKKNPLTRNTGCLIVGADSCDPQLFTKEYCGLFNEAGVMPKRLLARFHVSPEGALQPGTPLFATHYKVGQYIDIRGKTIDRGFQGVMKRWGFHGMPASHGVTKTHRRPGNIGSGGNKARVMPGTKLPGHMGNRYRIVKAQRIIRINTRYNVIWVLGQASAGETNSLVQFYDTFLPLKSCKTLNSPPHFPTYIPRNEDEVLPEELFVDDLHNFNDPTIMYEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP53</accession>
    <name>A0A232EP53_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003007">
        <property type="protein sequence ID" value="OXU20134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP53"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7143" checksum="EF74924404F29503" modified="2017-10-25" version="1">MEIGLQVLRVQFIKFVNFHDPKTEGLLSSDQLTVTSGFKGNAGMSHCTLRACRPIFMAKQCIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPD1</accession>
    <name>A0A232EPD1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002956">
        <property type="protein sequence ID" value="OXU20220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPD1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14263" checksum="B55A0DB194E4B3EA" modified="2017-10-25" version="1">MRDFSISSTCNIRHYSKVSKPQKIAAMKFLVAFGVLCLVALSTQTPLFEGCDENIQSIFKNDSCFHVKCQEFNKMAVTFHQMTYHQCFAPKCKEGTLLKGQNPADVSKVYPHCCATPICEEPVKSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPI6</accession>
    <name>A0A232EPI6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002946">
        <property type="protein sequence ID" value="OXU20242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPI6"/>
    <dbReference type="STRING" id="543379.A0A232EPI6"/>
    <dbReference type="OrthoDB" id="432281at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24172:SF4">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="378" mass="43194" checksum="7E98A610A1A485A1" modified="2017-10-25" version="1">MISRIFRSQNFSRRRGTVLGVVARRSTDKRLDRSSNYSAKRSRNVSRYVSIQFCQPRQAGRKVRKGEETEQEGNSEETQENEAENEIENENDNDDGYPQSPDLDSPESLFASTERDENGQSSLHFAANRSHAKDGLYHLLQERQINIAFRDSRYRTGRDVAQLSGNPENVQEIDRFVVYLAARGETDKLVELLMEGYDHILDTEDDGKNVLQIAEEEDNKSTVEFLKSIKNYTVRIAIAVKSFGLELRDDIHRAIRAGESLKVRELLEVNGEGARLLALGKNSTGRCSLHIAVLREHEDIVRYIAKTHPETLRVGDNLERTALHYAMGVPSVENMSSILIKAGAKRVQKDLRSRQPSYYFMNKTDIKQLQDEEESMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPR0</accession>
    <name>A0A232EPR0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_010307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mab-21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002908">
        <property type="protein sequence ID" value="OXU20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPR0"/>
    <dbReference type="STRING" id="543379.A0A232EPR0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF42">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="13">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="363" mass="42170" checksum="60DC9A4791DB536A" modified="2017-10-25" version="1">MENSQWMEKVMSKTYDRLKKVDKNYELTVEDKTYVLKQYKKSGPAFTIYVQPKDESEADHIMNVDLVPCLEFEDITLDGYKQISNMTNNIIIVAKPSNEPDGHHLWRLSFYEQEKKMLQENEAGKLKPIIRLIKKLRDKLEWKKLASYYIETLCLHELDARKAENDIQFFRAPKASLFIYMLEKLREAISLKKLPYFWHEKYNLFANMTDKMTENYANRLKSILNLIHKNISINRFIIAEQMLSDSEVSALRAIGNAENVADLTTSMEDLDISGSQKADISEVESIDVMNSSETSNAEFDTFDSPNQDIGNTAAEPTTIKSRIEFICKELTALSNLKNEIFEEEKEKLRKSCMSLYITLSTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ05</accession>
    <name>A0A232EQ05_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 25 member 32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitochondrial FAD transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_008349</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FAD(in) = FAD(out)</text>
            <dbReference type="Rhea" id="RHEA:76535"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002875">
        <property type="protein sequence ID" value="OXU20397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ05"/>
    <dbReference type="STRING" id="543379.A0A232EQ05"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015711">
        <property type="term" value="P:organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000025">
        <property type="entry name" value="mitochondrial folate transporter/carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="227"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU20397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="312" mass="34753" checksum="A49C1D6E5A3A5357" modified="2017-10-25" version="1">MCATKSTDSKNKLSVFSHLKYEYLAAGVAGGTISTLVLHPLDLIKVRFAVNDGRVKSAPQYSGPINAFGKIVKNEGFVGLYRGIVPNIIGAGAAWGSYFFLYNCIKTWIQDGNTTKPLGPWMHIVAATDAGVLTLLLTNPIWVVKTRLCLQYAEDVHLSETKRYSGTIDALKKITMTEGITGLYKGLVPGLFGVSHGAIQFMLYEEMKVKYNLYRNKPIDTKLETTNYIICAAVSKLIAAAITYPYQVVRSRLQDHHHNYQGTLHCISSIWKYEGWRGYYKGLSANLLRVTPATVITFVVYEHVSSYLLSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQE9</accession>
    <name>A0A232EQE9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002794">
        <property type="protein sequence ID" value="OXU20552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQE9"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="391" mass="45526" checksum="10D0D1F6C985DC34" modified="2017-10-25" version="1">MTTTMKTDVYGIENRLFSISFKVIKLSGFWRPTTFRKPFDYIYEMYTLFCLVSILMLIATIVVDNVVTEKSIRSLIENLYLILTVSNGISKLSNIYLRRDRVISMLRRNSEDRWSVHRDDEEARIVEESIESESYIIRFCIYLVTINNVSNALNPILNPDPEHDLMVDAYSPCDRSKSDLCFWTAYLYQVFGYVSTSLVHVGCDCLVFNFVDRLCAHLKILEHRILQLPDLVEANACDEIRYLKSCVEDHHSICEGIKELNDTFYETIFIQFVTSISVLCTNIYLLSMQDLFSAEFIAVFVYLCCAFVQNFFYCWYGYKVSVNTLRISDAIFNMNWCILKRDSKKILSYVMMKTSQKVFLFNSAVVTLTPESFVNILKVSYSAFNILQQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQU4</accession>
    <name>A0A232EQU4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_016467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002717">
        <property type="protein sequence ID" value="OXU20702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQU4"/>
    <dbReference type="STRING" id="543379.A0A232EQU4"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14997">
        <property type="entry name" value="7tmA_ETH-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="58"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="348" mass="38986" checksum="F6ADADF88F957FCE" modified="2017-10-25" version="1">MTIFNDTTYYEGDDVTIFASALVTNTPKPVNDFYQLPIYMQVLSVLICVIVMVIGIIGNLMVLIVILGAKDMRNSTNIFLVNLSIADLCLLLVCTPAILVEVNAGPEVWVLGKAIPFIESTIAHASVLTILAISFERYYAICKPLQANTITMIVHPHNSYVCTKSRATMICILDWIIAGFCTSPFLLMVTYKLEVDARGTLVPICATEALAQWSIVYIATTIGAFFVVPVIVLAMLYSVIVYRLVKRSAIKHEMNRHSLHNRNQVIRMLCTVISAFFICLLPFRAMMIWVIVSPLEELANFGAEGYYCLLYFSRIMFYLNSALNPIFYALMSTKFKNGFLKILKAAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERT0</accession>
    <name>A0A232ERT0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triokinase/FMN cyclase</fullName>
            <ecNumber evidence="2">2.7.1.28</ecNumber>
            <ecNumber evidence="1">2.7.1.29</ecNumber>
            <ecNumber evidence="3">4.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_015499</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>FAD = riboflavin cyclic-4',5'-phosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:76202"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.6.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.28" evidence="2"/>
    <dbReference type="EC" id="2.7.1.29" evidence="1"/>
    <dbReference type="EC" id="4.6.1.15" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002582">
        <property type="protein sequence ID" value="OXU20996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERT0"/>
    <dbReference type="STRING" id="543379.A0A232ERT0"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034012">
        <property type="term" value="F:FAD-AMP lyase (cyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase, L subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="17">
        <location>
            <begin position="9"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="16">
        <location>
            <begin position="373"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU20996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="576" mass="61604" checksum="C526F41B400D65C3" modified="2017-10-25" version="1">MAGKSLLNSLADAVNESLTGCILTYPHLELHASKRVVLKPTWNEPSDKVSVISGGGSGHEPFSAGFVGDGMLSASVSGSIYAAPPSGHVLHAIQSVSTNNNAGCLVIIPNYTGDCLNFGLAIEKARYLGIKVSQVIVGEDCSIPDDEVGRAGKRALPGIILVLKVAGAVAQEGHNLEEVTNFAQMVADNMASCSVGLTACTIPGQGRMFELPEDEIEFGQGLHGEAGYKRIKLQSSSKTTALMIDTIVKALKLVKGNSVAVLVNNFGGLSQLEQGVVVKDVVTQLENMEILPLRVYAGLVMTSLDSVGVHITILKIPENHKTAVINALDEKTDAPRWPGCSYSLPPKYYNAPAKEEKLSKILVGPSLTTEQEKLLKICLEKACREIIEREKIINDLDRGCGDGDCGTTLKHLGEGILSTIDKLPLSYPSSLLSELANIAEDHMGGTSGAIYSLMFTAAAVEMSKINNAENWLKVWAQVWRAGINGIMKYSKAKLGDKTMIDVLEPSLNELDKNLSLSYKEAARKVAICAEQRSEATKHMVPRAGRASYVKQAEYLKGIDAGAFAVATWINAISEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERV3</accession>
    <name>A0A232ERV3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002551">
        <property type="protein sequence ID" value="OXU21072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERV3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="24" mass="2761" checksum="C468FE5A96E273A3" modified="2017-10-25" version="1" fragment="single">MSFITHDPVRYSTNSLKLAELNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES12</accession>
    <name>A0A232ES12_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002517">
        <property type="protein sequence ID" value="OXU21153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES12"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="230" mass="26888" checksum="FE2D11232555CA02" modified="2017-10-25" version="1">MCSCISCYTCTLLTLLHKLARRLMNDIKEKTKMYQFLYIVVFVLAFTIGNRAEAEKLKINQKNKRTQNLEPQIKLISYKIHSLNEKYATMHSYAIKKENATYNKLQKRMTINQDFPPVIIDVKVYATDKNYKNSKLLLHLDVPPCSESRYREFLPKALVVPKSMLQSNCLKKGDLNTDDLGIFRFDALIPNIHEISDYYKVDYNMTTADDPKEIITEETLLTEWGYLHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES63</accession>
    <name>A0A232ES63_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_008682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002482">
        <property type="protein sequence ID" value="OXU21209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES63"/>
    <dbReference type="STRING" id="543379.A0A232ES63"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000008">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF36">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="933"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="12">
        <location>
            <begin position="125"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="12">
        <location>
            <begin position="391"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="570"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1263" mass="140125" checksum="1227F8D283232D4F" modified="2017-10-25" version="1" fragment="single">GGQGGGGGTGDDEAPKDPGARITHQSHQYTEKDFEGHRAHTVYVGVHLPGERRHRRHHKHHHSRNGSGKEGESEGDRPGQQLLMARRGRLASICDPNGELIFTPPAQRVQFILGEDVGDDAHESHPLFSEMEELVKDGDEMEWIKFEEDVEEGGNRWSKPHVATLSLHSLFELRSLLLNGTVMLDMEASGLEQITDLVLDNMVNKSVLSINVKDKVREALLVRHRHQFERRKDNNMSRLPIIRSLAEIGRNHSSSKNCDCSCGMHALLTSDFQERRDNGDAYAPAVARSTSCPDSNTALLSKEAKDLKGPYLLVPDEIGIPYVVGFTTWFAMCPLKVEESNSAPAIAAVGQGGGAGLNPSGRFLAIPGNPGQEPGPMGIDRSPSSMSISRNHSSSALENGDANHRGNTHFMRKIPAGAEASNILVGEVDFLDKTLSAFIRLSQASIMGDLTEVPVPTRFIFILLGPTGGISSFHEIGRAMATLMSDEVFHDVAYKAKNRNHLLAGIDEFLDAVTVLPPGEWDPTIRIEPPAAIPSQDTRKRPKEEKLEEIDEEADEQKLRDESGLSRTGRLFGGLINDVKRKAPVYFSDFKDAVALQCVASFIFLYFACLSPIITFGGLLSEATGKNMAAMESLVSGFVCGLGYGFFSGQPLTILGSTGPVLVFETIVFEFCKKYDWDYMSFRFWIGTWITIILIILVAIDASALVCYITRFTEENFATLIAFIFIYKAVENVLTIGKKFPINPHATDVNFSSNYELCLCKPPNSTLNLLPPGHEHVNWSAMSRIACQNFNGTVIDDCHQPHYVPDVFLMSIILFMGTFLVSVELKDFKNALFFPSKVRAIVSDFAVIIAIFSMSLMDYFVGIATPKLEVPAEFKPTLDGRGWMIWPFNRNPWWSALIAVAPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLDLFVLAILIEICSIMGLPWFVAATVLSINHVNSLKLESECAAPGEKPQFLGVREQRVTHILIFLMIGCSVFLTPMLKHIPMPVLFGVFLYMGVASLKGLQFFDRIMIMLMPVKYQPDYMFLRQVPLKRVHLFTLIQLTCLACLWIIKSFSSTSILFPLMLVVMIGIRKSLDLLFTQRELKILDDVMPEPHKKHAEDLRQLENGEEHNESIGFASSGNLQIPLANGNIMKIPLTSINISEEVNKTGIWQQVNEGNDKNKQSNKLINVGKQKKHSKKDAVLSTDETTRLTTMTEEDEDDGGISIKVDLIRSKDTSPFKANGTTSAETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESF6</accession>
    <name>A0A232ESF6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Forkhead box protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_001244</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with melt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002437">
        <property type="protein sequence ID" value="OXU21272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESF6"/>
    <dbReference type="STRING" id="543379.A0A232ESF6"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008286">
        <property type="term" value="P:insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040015">
        <property type="term" value="P:negative regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050778">
        <property type="term" value="P:positive regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010883">
        <property type="term" value="P:regulation of lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20032">
        <property type="entry name" value="FH_FOXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000032">
        <property type="entry name" value="Forkhead box protein O4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="18">
        <location>
            <begin position="126"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="16">
        <location>
            <begin position="126"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU21272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="512" mass="56431" checksum="7D7F436CDA113EE4" modified="2017-10-25" version="1">MLPEVPGARGGQYQRRLLEFHEKLTTYLVDTYSEWTSLNALFEMEEESRMEMYVGNIFEPLTRGRSNTWPQPRPEGYVDGPPLIDGAAMTGNAESLRIDPLTQQNSPGQGAGPSAIKKKSPRQNAWGKLSYAELITQAINSSKDQRLTLAQIYEWMVKNVQYFRDKGETNSSAGWKNSVRHNLSLHNCFIRVPNESSGKSSWWTINPDVKSGKTTRKRAASMEAGKFEKRRTRVKKLVEASRKANPHLDVTSSASNCVSEGIEPFHYGVSPLQHIAAQSPAFQARASSSASSAGRLSPILAANEPEWTYGHAHGQTAASPADQLTVTPLHQINHTSALDQQPMRLSATCQMGQPEAPGNDLQSLPVACSFDRQVAQMCPVHRLDVCNCDLSMLQMDTRTQAANAAASHAHCATDGPNHYFNATYGNQYGVMASQTTLMPIQEMADFGSIADLQIESQQPMVRNNSMLDDIDEIIKKDQYAAIDLVNTSMSTALYISGNNPVNSVGQNSWIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESK1</accession>
    <name>A0A232ESK1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002412">
        <property type="protein sequence ID" value="OXU21338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ESK1"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="188"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="543"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="90970" checksum="C92F7F720ABBEC5F" modified="2017-10-25" version="1">MMSINKKVAAKRMSFYPLSVNSTLHLNKFTFCWKIFHFEKVLDGFKKKSPLSSPIFPPENSNGVEWSLLLYPNGENPKYTDYISVFLALQLGYPNTIIDFTIALLDDKGNTLERRSIDDAEFKTGHFNICWGFYNFCSKDKLKSVLNDQSISNTITICCEIDYKTGRQDTGPKYLSNMVDMLDSGRFSDVTLICQGKKFKAHKMMLALRSPVFSVMFEHDMKETRESVVEIPDVEPEIMQELLQFIYNKKVDKLKEHASPLLIVASKYQIEDLLXFSWRFNSDIQTRSSTSQSHYSTTRDTGPKYLSNMVDMLDSGRFSDVTLICQDKKFKAHKMMLALRSPVFSVMFDHDMKETRESVVEIPDVEPEIMQELLQFIYNKKVDKLEEHASPLLIVASKYQIEDLLDMCQKLLIGNLNNKNVVSMLTFADFYDAKKLKTKAISFVLANIKEIVSTPEYIKMGVSHGHLLQEILTAMALREGEVTELKKSKFVKCFTSEDFDHYPTQTRMTRRSQLASDHDSFYVTDPIRMVDWQSLFVPMRWFSDVTLICQDKKFKAHKMMLALRSPVFSVMFDHDMKETRESVVEIPDVEPEIMQELLQFIYNKKVDKLEEHASPLLIVASKYQIEDLSDMCQKLLIGNLNTKNVLSMLTFADFYNAKKLKTKAMSFVLANIRAVVSMPEYVKLGVSHGHLLQEILTAMALRDGEVTELKKSKFVKCFTSEDFDHYPTQTRMTRRSQLASDHDSFYVKNPRRLLVLQSLFVPMCYCCFTYEQQLYDGSARLKRLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESZ3</accession>
    <name>A0A232ESZ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002371">
        <property type="protein sequence ID" value="OXU21437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESZ3"/>
    <dbReference type="STRING" id="543379.A0A232ESZ3"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="271" mass="30059" checksum="985A5E966916FA39" modified="2017-10-25" version="1">MRSKEKLKLDPALRSYLGHCSSHSRTRGGQITEKMFQDVINNSKHSDNWYDPHGEIRALHVMNPLRKKFVRDLLANVVLKKQTRVPLEDIKLLDVGYHRRILSKSLAIIGANITRLDASKELISIARQHVSFDKYLSSNLNDVHTSIEDCLQKQKEKFNAAVASEILEHDGIKGYDFKLYQPSATRFCFCSSFKAIFEAPPKTAIEAAVLATVPATIGSAIRALFGTPTTDIEAAVEDSVPAAIGTPRDVNGAIDSLVMGLRNDSSGTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU78</accession>
    <name>A0A232EU78_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002164">
        <property type="protein sequence ID" value="OXU21901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU78"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="17094" checksum="049DB2F1F491A729" modified="2017-10-25" version="1">MEIYDSRYFIINKTLMTKMGLWPYQHPLKKLLVRTFLVVFIFVSSMPQLYGLKKNFGVHMDKIIEHLALLMYIYGIKLKLVTSILSEKKLKKVYENIVENWQQIKDEHERAILVEYSERGRTLTIGYIKIQPFILTFIQKDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU90</accession>
    <name>A0A232EU90_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002158">
        <property type="protein sequence ID" value="OXU21912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EU90"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="29"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU21912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="326" mass="37673" checksum="22AF17D9E81B303C" modified="2017-10-25" version="1">MLTDRLPFCMHATLITSGISRLILQCFQVFDYCPMIPFRPVIEPDHPGAFLKEDPAISLKNGRLSDITWMTGVTSHEGTLRVPGLYGLNNXEYLVRLYGLNNGALIKRLDKDFENLAPTTLLFEDTCPKQNYKNVSKAIREFYFGDKPLDKSTKYEVINMYSDAWFNYAADEAVRDHLKLFSSPIYYYYFSYRGSASFSRIFGDPTEDYGVSHADELQYLFPVGEQLFQDIPLSKEDNRIIDIVTALWYNFAKFGNPTPEITPDTPTKWKPVHTPALEYLNIGNSKDIHMSKNLFPERLKFWSDLMPSIRDIDGVTYQYKPIRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUF8</accession>
    <name>A0A232EUF8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_012669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002131">
        <property type="protein sequence ID" value="OXU21989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUF8"/>
    <dbReference type="STRING" id="543379.A0A232EUF8"/>
    <dbReference type="OrthoDB" id="5395350at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000026">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725:SF14">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725">
        <property type="entry name" value="ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU21989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="472" mass="53157" checksum="9FC65D9DA5A45427" modified="2017-10-25" version="1">MEKNHKNTDCYFFYYSTCTKGDSCAYRHEASALGCETVCSYWQQGSCLNQHCNFRHMDIKKNRKVIPCYWEKFPTGCKKPHCPFLHRLNRSGVPNPIESVKAGSTPAKPVNQEWSNRQDAKFDGNSTESEQGRGSSEAGSFIGSPVVDPLIVNFEEESDSESAPSPTKNLRNRISSCKTYEEIRLEEIQAESAAFYSYVLSEDYQNSSSPAAGGGKIKKQSSSRNQRLATGASIYGREKKSEKEKQDSDELNFEVLSLAEIRRRRSEKKAELNKKEEQEEVFLKDAVKALDELKSDVEITETTTTITVTRKKRSFYDAQSNDSKDSAKKARMQTMVGKAPPIKLRRRRITSISKEEGNAAEARKEVEERKAKERLAEESKDNVDSSSSARGQNVEVRVCDSSTDDNQSTESLEEKDKKDKSIMESLDDSLDKPLDVCDSAVKLDDKRRLPSIDAEDDILKDIDALLTDESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUG7</accession>
    <name>A0A232EUG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002130">
        <property type="protein sequence ID" value="OXU21999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUG7"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14291" checksum="DCB87094F2A554D3" modified="2017-10-25" version="1">MTKLKHLRPLLLRTKEHYCISRSVSKSPEDGREGSSSSTTGETQDQKPVRPMYVPEVPLTLEELQEPTTCCMSGCANCVWIEYAEKLSTITKDSPGDVQKLIMEKVQDANMRAFLSMELRVRKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVN8</accession>
    <name>A0A232EVN8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001972">
        <property type="protein sequence ID" value="OXU22414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVN8"/>
    <dbReference type="OrthoDB" id="7695893at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="120" mass="14073" checksum="7D69186D0755BF3B" modified="2017-10-25" version="1">MTEEVKNKQENDQEMSGVENDHEMTEVESNHEKVLQNLNSSITDTKILVEKVMKMRLQCKELQMNTLRLFHPTCIKIMNISNELSGKSVNQLNKDKKKEIKQLNGKDKHRVHFEKSVNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW69</accession>
    <name>A0A232EW69_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein phosphatase 1 regulatory subunit 12B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Myosin phosphatase-targeting subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004087</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NRARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001921">
        <property type="protein sequence ID" value="OXU22566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW69"/>
    <dbReference type="STRING" id="543379.A0A232EW69"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21930">
        <property type="entry name" value="IPD_PPP1R12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000004">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000007">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="411"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="640"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="729"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="729"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU22566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="925" mass="101361" checksum="BD5A09C1D8ABB27C" modified="2017-10-25" version="1" fragment="single">MSLENRSSSALFKRAEQLKRWEQSETNREPPRPRQVTRKIKFSADCVFLAACAAGDKDEVIRLLQKGADINTGNVDGLTALHQACIDDDLDMVEFLVEQGADINRGDNEGWTPLHATASCGFISIAKSVTVNPAEYLIEQGCNLAAVNNDGELALDIAESDEMEEMLQKYIDKAGKWSNAGKREKKTFPNSLSLIKLSHGTGRHPPFHYHRRLHVVAQRRTTICLSKKNQLCKIGIDCDQARSEEERLMLSDARAWRSGAPGKDAVHPRSGATALHVAAAKGYTTVMNILLQARCDVNARDNDGWTPLHAAAHWGQREACRLLVENYCDMDIKNYAGQTAFDIVDSSILNTFEELKKKQEVLLKDHPQIINKQPAIPKKRVSTNKENLVIDQEGTETYVEETPNKVKKVELEIQSDKEESSVGTNSDVEEGVDTDVDASEGESESETSSDTQTSTCSDQSNKSNRSNNSTCLTDDEKKNRVNREERASHSPQPSLDVNKVPNQAPVAPPKQQIENNDEGSIPSWRRSGSFRNRGLETEATNSISTRIEEREKPVIKTPPSPTKVPEEPEVVLRRTHSFETDEKKKEIKLNLELTRVPQGNSLQSPSLPNKSLPTSPVSNLSANAVISPLPANQIRRSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEQLVKKKQQQSNDVAGSTATGTTTTASVTQGLASAGSNSTTTASITATITTASPTTVSASKPSPIASSTSTTGTTAIQSQPSLTTTATTTTTTTTTSAEVETNLPERRPSWRLKVDSGSKFQLEDANNRSTSVDTTTAYIRRPTGGGGGGGSTLPRPSSAPVDSIASSTAETTVTLPLRRPLKPPEDKEQDKENDSRNAQATQAVIQRRRRPKRRSTGVVHVDMDEIDPEKQDIPASGDYDDTKINHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWX5</accession>
    <name>A0A232EWX5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uridine 5'-monophosphate synthase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
            <ecNumber evidence="7">2.7.11.22</ecNumber>
            <ecNumber evidence="6">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSAR_004592</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Alberta</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EC" id="2.7.11.22" evidence="7"/>
    <dbReference type="EC" id="4.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01001812">
        <property type="protein sequence ID" value="OXU22847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWX5"/>
    <dbReference type="STRING" id="543379.A0A232EWX5"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000025">
        <property type="entry name" value="Uridine monophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="4"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="21">
        <location>
            <position position="724"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="21">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="21">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="862"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="863"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OXU22847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="893" mass="99367" checksum="52B82B92C5CC3A7A" modified="2017-10-25" version="1">MDKYENIEVVGEGSYGIVMKCRHKETGQVVAIKKFLESVDNVHVRKLAFREIRMLKRLRHENLVSLIEVFRRKKRFYLVFEYLDHTILDELEAVGGGLGLELSRRHIFQVLRGLNFCHNNHIMHRDVKPENVLVSPHGVIKLCDFGFARIVSGPNESCTDYVATRWYRAPELLVGDPRYGRAVDTWAAGCLFAEMLTGEPLFPGDSDVDQLFRITRLLGGLCGRHQSLMNRSSNARSEARALRKASIESLSYRSSSGTNNPGAGIHRGSSGALPSLRALLPSCSSTCLDFLSQCLRMDPETRPSCANLLQHPLFMQDCFAEKFLLELREYVAQEASENPLLQMRRDEERRLSVLSLEEPQRIYSGAARWHMKLIPSMSHEKPADHTDTSRNSLNQALRSRLFSVVAVVSRCTSGIKIEQMDTKTKLRELAVELYDVGAIKYGDFVTKVGLKTPIYIDLRVIISYPKLLVQISKMLWSLMDDQSQYSHICGVPYTALPIATVISAETNVPMIIRRKEAKSYGTKKLIEGVFVPGDSTVIVEDIITSGSSVLETAQDLIREGLRIGTALVIVDREQGGKKNLESAGIKVKSLFKITELMQALMEAERLSPGSVSVVADYIRKVEAPMKIDKIVSDPRLSQDFATRAKSAKNPVASNLLKLMASKKTTICLAADFTKTSSILEIADLTGPHIAALKIHVDIVEDFSRDFIAKLKSLATNHSFLLMEDRKFADIGYVVSQQLSQGLYRISEWADLITVHAVPGKGILDGIRTGWDRLTDQRGLFIVAEMSSAGTLTTGDYSNAATSMAKDDASVAGFVCQKNVFSDPGLVQLTPGVKLVRSGDDFGQQYNTPEDVVKSGADLVVVGRGITDAEDKLQAVLQYKKMLFEAYEKRLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXV0</accession>
    <name>A0A232EXV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2A'/phosphoprotein 32 family A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001745">
        <property type="protein sequence ID" value="OXU23048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXV0"/>
    <dbReference type="STRING" id="543379.A0A232EXV0"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="67982" checksum="9AD002CCEF4E863A" modified="2017-10-25" version="1">MVRLTEEMVTARTRVSDCAAVKKLNCWGTELTDVSILRKMRNVEVLSLSSWSHPTDQELVPPTHSFIGSRMSFLVLNSLELNKGLHLENLRHLIFPNSTLFPIKNQYSESMRHISVDMRLKIKFIVNNINSLADFQNCVDLKDLFVRKNNIRDLNEVCYLQALPNLRNLWLGENPCADVDGYRLAVIKALPNLEKLDDKIVTPEEVQTAMLRGRSLIHPLTMMQAESSSPQSGRGSPEVVMAKYSEDQDVDQRRNYSSSDEQRSYDEAPPAEDYQETDKRNANYNTSPVHQYPPNNRYSYEDNDRTTVLRQNGEYEELNQRMYAPVSPRSQYPPTEYIDERRMEYEEPQRPPSAQSKRGMMNQSMEREDFNQSAGWMRRAEKDKRRSQFQYQRRPVTRNSNILSAVLCLVKELDYPSLEVVEMAGTVLPSYLQQQQQFGGGVSVPSPEYSDSLDSTLTYSQRSTSANDYNLNVRELSSEACSREDSPCRLFSASFRSTTSSTTFPCELASRLRDAAVVEQEDRTSNEVRRVASSDSIPVNRATPGSADRGLFNRSYRVLSQDCVRRAKSPDVRNPATQLRYIQSAKGTWTYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYL9</accession>
    <name>A0A232EYL9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001606">
        <property type="protein sequence ID" value="OXU23445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYL9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="127" mass="13677" checksum="D2387B9D2BB327E8" modified="2017-10-25" version="1">MSKTTTTTTTICIIAALTFSLLLDKTAALDLLLGNREPGDKLLQKSRMYDAIRDPEGPAILWKVLTGDGKSTISQLVIRDRTQGCGTVVPINGGPGSKFVVLQLISAKENPSSWDCTSDYSVEIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYS7</accession>
    <name>A0A232EYS7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001589">
        <property type="protein sequence ID" value="OXU23505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYS7"/>
    <dbReference type="STRING" id="543379.A0A232EYS7"/>
    <dbReference type="OrthoDB" id="8193468at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF28">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="459" mass="52863" checksum="E16628CDB016A393" modified="2017-10-25" version="1">MVIKVDNRKGVRYNQRVGADLEFADHELLLSDLPIVEEKFNCDQRGETLMNVRAWVENHDKKHLRMLPLINVLESGVVEPNDRREFVRIAVSGMIEFNDGNLYPSCQLKTQLAKDIVTAFPKLCSASGGYVSLEHFYDPKTNRGFIEFRLKTLRLKLNPSEKKRSVGPQARERKTAKASPKFVTNERLLDDRDFNAKVLDLYRMAPTDENKLEIFRLTEAIRANRKRRSMVEQMSLDTILNVFPRYKDFNGEVIRREFLNAYPNNDTFLDLFPSFYAPRILQYCSAAKPLFLQAIQDIPDNNLKALILLPELLPSPNYTKRKENKNEPKALFKIKSMKTIPHENLLHFVNMSDLSALNQIYADRKSPFLICHTINQEKIGTFYVKTEGHLIHIGDDAMLAFDVLLKLHYCFDMPFASDLVCFYDFITGCVLRLHEPKGCCVALNSTLSNVTLTNANLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYV7</accession>
    <name>A0A232EYV7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001592">
        <property type="protein sequence ID" value="OXU23489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYV7"/>
    <dbReference type="STRING" id="543379.A0A232EYV7"/>
    <dbReference type="OrthoDB" id="10263345at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="558" mass="65179" checksum="FE918896583A525B" modified="2017-10-25" version="1">MKSSTNDYLELKFLKNMELDLSFSEKSFTSDFEILESTYEEYFSSSDSFDASRFELMNVPKRLVSEDITAQCKRLICQYNVILKKVLLLILDKQVKFQEQFNRVIKIQEKLDNVLKICESCRNNLKTASHHFSLSSLLILYYCRKRKILKNLIMILYGIKTLNRTKDKLQQLLDSENYPTVIALISDCKRSIDTYNKYNCVVAVHDKLMDTLEFVEESLDMSISKICTSFNANNYASAQDAYKFLGKSQTAIDQLHMHFIATIHSTALSLVLKYAQNDMKSQYNLLCQYVPLNKFYPCLLELCESFLSIWKSYYFVMKWHENEGSTNTENNGYENIIKDHNQKYILQKLQAGIVKVCNDVETKLIIFIDGFDLTNLKFEELLQALNTVDRMLKIGKILCKSNMTKLYECSKNKLLMYFDFYHASRLEELKIFLENDGWGLCPIKSSFRVTQLLEFKQFKNIFNLSQNSRNTEENLFQIVDDFDIYDFSQAFSINASLPFDLNFDKPAEEDILRSSEFGREKVTRRPQRGKISVPSTATHGREENPYSTLCLTIQMRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZC6</accession>
    <name>A0A232EZC6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001556">
        <property type="protein sequence ID" value="OXU23610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZC6"/>
    <dbReference type="STRING" id="543379.A0A232EZC6"/>
    <dbReference type="OrthoDB" id="10038672at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057809">
        <property type="entry name" value="ZCCHC24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23490">
        <property type="entry name" value="ZCCHC24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="5">
        <location>
            <begin position="122"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="198" mass="22903" checksum="DEE8D605B5D83B8B" modified="2017-10-25" version="1">MRKEHSSIIKYELLSLQSSKLLSNRWGSLPQSQSQANYQQSAPSPTSNDLGQNHYGSSLNDSITDLTEYFRDLLIVQKKPPKRPPLDYMCHACFWAGHHYIRDCPKAHPKGKGRTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKVHPQQLCEKCKTLGYYCRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZW4</accession>
    <name>A0A232EZW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001474">
        <property type="protein sequence ID" value="OXU23843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="160" mass="18159" checksum="71A93F9CFCFA4017" modified="2017-10-25" version="1">MHGCIGISVRVYSWLEEATVRVIVQLTVASKSQSSSHVNHARRAMSSSGFSSSSLRGHMSGSFFDYHLAKRRVTSRRDLLFFCSPNRQHGAFLAARESESVENFGEVCPGLLYAELMILEWIGFSFSDLVTHTYWKNINLGHNTLLLGSFHHEFWFQISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0H8</accession>
    <name>A0A232F0H8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="13">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="13">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="13">PHB:PPT</shortName>
            <shortName evidence="13">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">coq2</name>
        <name evidence="14" type="ORF">TSAR_016544</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17709"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:84502"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:44505"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01001370">
        <property type="protein sequence ID" value="OXU24205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0H8"/>
    <dbReference type="STRING" id="543379.A0A232F0H8"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="415" mass="46597" checksum="32D790998EFE9148" modified="2017-10-25" version="1">MMIVIGGCQRLTCVTRVLNTFSHNLKFHMKDDIYIYKKIHTSSAINTTSNKQHNNEHWHSQPWFRHIQPTSHRRRSDLPEIFHQTNRNASIVAKLVEKAPSKIQPYMKLMRIDKPIGSWLLFWPCGWSIAMAAPAGAFPDPGMLALFGIGAFIMRGAGCTINDMWDKDIDKKVARTKDRPLVTGEVSQMQALTFLGGQLSLGLLVLLQLNWYSIILGASSLGLVIIYPLMKRITYWPQLILGMTFNWGALLGWSAIQGSCDWSVCLPLYAAGICWTILYDTIYAHQDKIDDALLGIKSTALKFGDKTKLYLACFGTTMISSLVVSGICADQTFPYYIAVGLVGSHLFHQLYTLDINDPSNCAKKFISNHKVGMILFAGIVLGNLAKNALNTRRTDMDKLKNVERRNLLREVTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0R5</accession>
    <name>A0A232F0R5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001398">
        <property type="protein sequence ID" value="OXU24113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0R5"/>
    <dbReference type="STRING" id="543379.A0A232F0R5"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10974">
        <property type="entry name" value="CE4_CDA_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF3">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="523" mass="59566" checksum="1640EFE22924A3AF" modified="2017-10-25" version="1">MARIPAIRALLLLVVALVIGCVSGQGSGNSQSQQKKDEEFKCPEGQGNGNFADPATCRRFYQCVDGYPYLNRCPSGLHFDDISKFCTFKNEARCGPIAVTPAPITEAPTDLAERCDTAKCQLPYCFCSRDGTIIPGGLKPSDTPQMILLTFDGAVNHNNFDHYQKIFNSDRVNPNNCPLKGTFFISHEYCNYNMVQSLAHDGHEIATETISLQKGLEDKNYDEWVSEMIGMREILKHFSNISSSDVVGMRAPYLKPGRNTQYKVMEDFGYIYDSSIGVSPGKTPIWPYTLDYKIPHECKAGTCPTKSFPGVWEIPLNAHYVESYEGGHCPYLDQCVLHSHDAQEVFEWLQEDFSRSYDQNRAPYMMPFHTNWFQIKELEKGLHKFLDWATTLYDRFYYAIRLLTVVLCRPDVYFVTATQALTWITDPKSIQSLTNYEGWECKKKNENDPGPPCNNANKCPLDFKPADANFTATRVNVFIVNRFTRLRRNRYMETCTECPNKYPWLGDAKGTGHPSDNYNVDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1L8</accession>
    <name>A0A232F1L8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001251">
        <property type="protein sequence ID" value="OXU24611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1L8"/>
    <dbReference type="OrthoDB" id="19659at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="11622" checksum="2C01BE60A9E13AD9" modified="2017-10-25" version="1">MTENVKQSLQDEKKTNTTSINSDMQVHFLNTSKKLSEGFLIIYRRPLLDINQEIIDLTIKQELCIKKLQLENKKLCDFQEHLELHNLVCLIFSYFSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1W7</accession>
    <name>A0A232F1W7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001213">
        <property type="protein sequence ID" value="OXU24714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1621"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2110" mass="238440" checksum="7A57299A6907ADE8" modified="2017-10-25" version="1">MSKDNEDRYCDYPFRLRKISGLPSDFIRPDVLPVREIPHETDPRRERSVQHALDLQRTRDENNPPPRDKPVNNDIPWKLRRIDDIDNKSIKLNDTAHMPHCRDPRRAEIVNPRPREGEATSTERPRPPTPNLVENFQIQVELATCPVLTVDRTEWPESVHSYIDVIPHECNILRASLSKMSEQPVDVDNENVNILLETIRRRENNDDVEIVEDDDVTEVSGYNSGDATKPMLSMNDVNRVYDVEFPLGSFLGDEELPPIPVVKPEPKLVRPVPSFDESNIDLVDLCDDDENAIVGGVIEVITLDSDDDGANNRGDASVPEESITPTEQHMDSTSRVSDRPRIPSFPRGQRESARRVLLPAASGNGVVNSDTATPSQSPQVLLDEVSSMHVDAEIRQVRDNDAISAAGRNRTWRHLDDARINEVQEVVEFDEISDSMKEADWADDSIIFRPNNDETGDGVINSDNENEPEFQMECETTEACENFDNEPCLLNNNKTDDDEPAPRRISIVTSEAFEAQKKLLIDVISHANDDMGNDSEYLDILPSPMEETTSQQTTPENVTTEQLQRVINDMTSANYLGRSIFANCSPIEDTTLACPEKRKTREKGQEFPEENSEEVPEPPEKERRTSERKESLDQDENTVVVSEPSEQRVLKVNTPAAVPNASSAIALLHQSKSMQYLPARNNAPPVMTSTIFNFDRALLNHLINYVRNFNIERSSIEFMLHDYNGLSVTRAMQVVNETFWRNRYNHWSHRDRDRSISTESSDLFISEDTIDILPQDDQIANNIDASYFLKFPGLKANKLAIESDMQTISQDSRFYSCYSFSKRPRSKSYDSCNNHNKSISPIKLTLTRDQSNQQNWFASTKKSPSISEYNNLGKTSHKLNYFTENVKTSCHLTLGFTKNQSYADKTVPELENNDYISKPIISDKFIGKQSLEKHLSPFLKSRIKRPHQVTETVDMLQSNFTSKRPKLSEQALDANINININYINNHLGCMSQQDIKSVELSQSFSDFSKKDLPKSFKNNVSNLNISLSYSDTCEKHNVLHIRSESNGNVQIDHNSNIAKNRHNIQNISSPKRKKSPEQNERGKRTSVEMNERKKMKIGQKFAEIFGDSDSDALEIISSPSNFASSEKGLSKDDSHHSDANCETNVTVKQVTLNKHDINATLEKLSKVSEIESVLNTAEKCIKMATNDIVLDQSEHSSSSIQENQDFGKSLKLTESTTLGVNESSKLSTRAVHPKKSDKNSMSLEKIETTTESVTINIKANELADKCVSKVQSNVSFEHFSSNTSEISLSKTTEINSPTSITEETSSKVTSEDQVEIHELTTISAKTNEFVDKCANTVQSNVSSDNTSSSTTFEVTSKDQELCNLNGTNCDSSKDNSVETMNLQEGDFDFQVDNRSVCSYDDCLYSDTAESEDLTCSYIVKIQGLGNDESTNNSKKPKNQHLLVSKRSEVTAEQNNTYCFEKSPTYINECVSNEISDSTGANNEKTITKDFNSYNAEESFDYDSDNQLIICESPVQNEVSSSTISFPNQNSPITFGNSNNINKETSLLSSIDAAEPNRTGAAPDENILADLKDINILKKYNLFIEEVPSESFTESIENQEELEAFESLKKINDYLENATYENIIEEHNNQSLNEQLKNLIEEFKKFNIHCIDIDADKVINATKSIDNSNSTVRKCSGTFKLRNINELLEKPQTNIDSANEKKAGKVVKTQSQEFSSIIESIYNSISSSLEQLILIVKSISFTKQIHSPVGIKNIPSTVSQFNNQSCENVLPVNLSQSTALANNSRVCIKLASNMFSNEFSTTDDLPTIYSMESPLLDTLQILMPALKTKEDVEKYKKLLISKLDSHLELLQNIPRKDIIRFSDDLLKYNTLSEKTWEFQQLILTIMQCISRLIYCAVEENKQRIIQIIEKTINLSKHKQVYLGEAIILYQKLATQGLCNKYIFLYDPLTNEFDVDRSPMPDKDFKMNDIQMTIYFEQITSYRSLQKLPHLEISDLKAIASKPITTHQINSFQSFSTNNVQMTVSNLGNAQNLEQMLNNHTILIPSCVPQSTGIQVPPVPMPINPLIQRVCSMCKKANTVMIICYYKNVVYCSLSCHARDWINCAKLSFYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F239</accession>
    <name>A0A232F239_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001189">
        <property type="protein sequence ID" value="OXU24805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F239"/>
    <dbReference type="STRING" id="543379.A0A232F239"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF270">
        <property type="entry name" value="ENTOMOGLYCEROPORIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="52141" checksum="C86884E418FADCBB" modified="2017-10-25" version="1" fragment="single">FHVKVDEFAQFFPQLRADFALIVLHTPQQFLRPITRHLEQTAAVHDNAGDETVDAGVSREDDTAYEDLGDEDDLVKRRVLDDEEDVLAGIGQRNHGRVVGLEDSGLQQRHDDVVRQSASVRQSQVGRGEEPADLGVLQHDLSVLLGLGHSVIVLHDLETVANVLLVQDQRPELEDRQRAEDLRGYDFHELAQVLGFEPCPDEVGLEPWKMQEGTSTMFLAEVVGTSILIFIGCMGCIGTMGPAPPPPMQTAFTFGLTVNLIIMTFGHVSGAHLNPAVTLGAVMIGLKSIPTGVVYCAAQFIGATIGYGLIKIVTPALLMNDGNPSSETPLCVTAIHPEVSVVQALLIEILCTSLILLGACATWDPRCAHTTDSTALRFGLSVAAISFAASPYTGCSMNPARTFGPALWHGAWKHQWVYWLGPMVGAALGTSAYQVLFSPKEAQSTSVGVETTNSEERDYESYKMTELQVNTTAEPENLAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F254</accession>
    <name>A0A232F254_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001197">
        <property type="protein sequence ID" value="OXU24781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F254"/>
    <dbReference type="STRING" id="543379.A0A232F254"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12804">
        <property type="entry name" value="AKAP10_AKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08721">
        <property type="entry name" value="RGS_AKAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000005">
        <property type="entry name" value="Putative A-kinase anchor protein 10 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037719">
        <property type="entry name" value="AKAP10_AKB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013212027" description="RGS domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="97"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="324"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="605" mass="68608" checksum="3DBE91C91B271355" modified="2017-10-25" version="1">MTTIKFIFLYLFRIGTKAVLSNKIHCFIGQRERSRSSYSSPTKSLSPGEQPSSYGFVGASVVAVPSSLCSFEEEEEDDVFEDGKSQVNSFRSQLSKTLPEILADKSALGYFIQFMDSRKEMSLIKFWLEVECLCGAYSSPEFLGNKDGCSKRTRELINSTNNLENVDNCACSIMSTSVSDFELDALSLDSNVNSNEQSLSLQSPINEIKSNFNPPKNSPIVNNESKKNCKFGGCKGSSLQQDAMRVYRKYLAKNALGSNRIPDELKAETEKAVMSENSELILKYLSQAQKTVYKILEEEYINDFLRSVFHCKHQIDVLTSGNVQLADILYNETAFFYFMEFMEIENKRELLDFWMTAMNYKQNLLEKGDLTDPTEAQTDALIIYDKYFSLQATMPLGFTDRIRFQVEQNICREDGKGPQPDCFDRPCQIVHNFLNRHYLPTFLQSQLFYKYLSELINSVQSSHCPAFHPPIRRAGSDCSSEISSVSNITSPVPSTSEDKRQSRYGTPVNGGMNIDTKQLYDPDSLWRRNKCSLSVGYVDSLGRFVTEIEPDPCRKNEKESRISRAVKRLVHIEQDKAKEESAWKIAEMIVRDVTSLTLGASDLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2A6</accession>
    <name>A0A232F2A6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001177">
        <property type="protein sequence ID" value="OXU24851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2A6"/>
    <dbReference type="STRING" id="543379.A0A232F2A6"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="28"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="537"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1065" mass="120784" checksum="63548E0FDFED9CD9" modified="2017-10-25" version="1">MYQRGNRVSSSPPPKRKLSSFCALDMREPIVKIRNGKLCGSFKRSPEGYEYYSFKGIPYARPPVGELRFRDPRPVESWAGLRDATEFGPICAQCDLVTQTVSGSDDCLYLNVYTTTIDQNARKPVMFWIHGGGFLHGCGNDLFFGPDYLLRNDILLVTINYRVGILGFLNLEDEISPGNQGLKDQVMALIWVKHNIQNFGGDPDNVTIFGESAGGACVHYLALSPLARGLFHKAISQSGVALNTWASMPPNPKKYAHQICSNLGRDLTDSRAIVHFLRKINCLTLIDAQEKIRTLEDKIRFIFPFGPGTDYKSPKPFMPIPPQVAAEEGIHVPYMLGYNSGEGIFFLSDLKQEGYEKVNEDFDTYLHPRIFETLHKNNLTPDDLKRLYFNGEDISEINHQRFADLWGDMHFVDGIHRVIRTQVDRSSASTYLYYFTYDKGFSFIKTKMNAQVKGDVEFIVKSACHGEELFHLFSIRILEGLSINPIKKGSINYRLIEQMTTMWTDFAKTGRPTPMTSKIIPLYWQPVINDTLLDMSEPIVEIANGQIRGIVKRSIEGYDYIAFRGIPYAEPPVDDLRFKDPVPVKNWTGIKDATKYGDICAQFDLTLRNFGGNDNCLFINVYTKSLKNVEKKKPVMVWIHGGAFLYGSGNDMHFGPDYLLRKDIVLVTFNYRLGVFGFLNLEDEVAPGNQGLKDQLLALKWVQQNIEVFGGDPNNVTIFGESSGAVSVHYLCLFHANKGLFHKAISQSGTSFHNWARVKNPKTYVYALCRALGNKTTDPKEAVTFLRSIGSDELVKAQEEVRRASDNVGNRFSFGPDIDDKSSDPYMPVAPEIEALKGVHIPYLIGHNNREGILALLALRKEKYQYIQENFEKTIFPRTLDTLKHYNLTPKDLRKEYFGDKAITLDTSGIYADMCSDLYFVESVHRVLKIQAEKSKTPTYYYKFSYSGQVSLTKAMLLNPITGACHFDEVEYLFFVKLRIPLGLGSLKRGTPGYRVMERMTEMWTNFATYGKPIPEKTTLLTEEWPPIDDGTNLRCLNINKFIAMETVENLEKRFLSIQSSSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2R5</accession>
    <name>A0A232F2R5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_013132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with ribosomal protein S21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001206">
        <property type="protein sequence ID" value="OXU24743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2R5"/>
    <dbReference type="STRING" id="543379.A0A232F2R5"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="316" mass="34329" checksum="4B8D21D3D892D46D" modified="2017-10-25" version="1">MSGGLDALALKEEDVTKMLTASTHLGTENVNFQMEQYVYKRRVDGAGINIINLRRTWEKLLLAARAIVAIEHPSEVFVISCRPYGQRAVLKFAAHTGATPIAGRFTPGAFTNQIQAAFREPRLLIVTDPATDHQPITEASYVNIPVIAFCNTDSPLRFVDIAIPCNNKGPHSVGLMWWLLAREVLRLRGSIPREIKWDVVVDLFFYRDPEEAEKEEQAAKELAPAVKEYVPVADAMPTESWANGSDPNAPATENWADDVPAGPAVEAAAAAPVAAAATPFPTSNEWNAAPISEEWSASTPAAEIVPASSWGGTGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F365</accession>
    <name>A0A232F365_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01001063">
        <property type="protein sequence ID" value="OXU25276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F365"/>
    <dbReference type="STRING" id="543379.A0A232F365"/>
    <dbReference type="OrthoDB" id="431432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF11">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="594" mass="68444" checksum="47A4EDE98C2565AD" modified="2017-10-25" version="1">MLQHMWTAYGERFEWFLRADDDLYVRMDRLEKLLRSVDSRKPEYIGQAGRGNSEEFGLLSLEYDENFCMGGPGVIFSRETLRRIVPHIKYCLANLYTTHEDVELGRCVRKFAGISCTWSYEMQSILYHNSSGDLAFTGKLKSKEVHRAISMHPVKSPPHMYRLHNYMRGLKVQELQQKRIELQRDMERMRDLAKGLTTVGSDSPRTSGSRSNHWDFVSRSEYSLGDSNPRRRLHADLKEGLEDVTREVMASINACSRQRGRFVEERQALYGYRRRTPLGADTVLDLLLLYKKYRGRKVTLPVRRHLYLHQRFTGLESREVQTTDADVSTIYLVVPVSGRQKALRRFLANYERVCLSAGQRTELLVILYPSHEDDASIMKSIERLDRNKVRLVQGTGKFSRARALDQGAALLNDDDLMFFVDVDISFDVEALARIRRNTIRSKRIYFPVVFSQYDPRIVYGTRGPPETPDISPLSGFWRLFGFGIVAMYKSDYEAIGRFDLTIEGWGKEDVDLFEKAVKSSLQVFRAPDLGLVHVYHGVSCDKSLKEHQFAMCKGTRADTYASTEQLASLIYRNPEYLDFARKTRAMANTSSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3C3</accession>
    <name>A0A232F3C3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001117">
        <property type="protein sequence ID" value="OXU25082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3C3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="132" mass="15672" checksum="B918D570B6148D83" modified="2017-10-25" version="1">MSASRKKKYFFDKNVPLTKYVKRKLRKIVKRRKDQITHRKLFNNNLDCETDNNVLSNLPVLETSQDLLHDQITHRKLYNNNLVCETDNNVLSNMPVLGTSQDLLHDNEKLSENSSYYNFESVDYNKLYKMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3R5</accession>
    <name>A0A232F3R5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001108">
        <property type="protein sequence ID" value="OXU25110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3R5"/>
    <dbReference type="STRING" id="543379.A0A232F3R5"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF4">
        <property type="entry name" value="AT19640P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012737251" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="10751" checksum="869E0944D40964C9" modified="2017-10-25" version="1">MLVAVLLLFLITEIPQGVLGLLSALLGDCFFRSCYHSLGEIMDILALFNGAVNFILYCSMSRQFRTTFGRLFKPSIVVGKWQPACTHQTDIQSTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4Y8</accession>
    <name>A0A232F4Y8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">microtubule-severing ATPase</fullName>
            <ecNumber evidence="9">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_004573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01000955">
        <property type="protein sequence ID" value="OXU25745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4Y8"/>
    <dbReference type="STRING" id="543379.A0A232F4Y8"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031114">
        <property type="term" value="P:regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02679">
        <property type="entry name" value="MIT_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19524">
        <property type="entry name" value="RecA-like_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000006">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03021">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017179">
        <property type="entry name" value="Spastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="MIT" evidence="13">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="567"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="809" mass="89905" checksum="75EF8DA186EF4E48" modified="2017-10-25" version="1" fragment="single">YTLASYINACPLSVNSLAKEWEEDPAAKEKQLGVLVVDGTQACRYPAWSALTSGMSERFGSVVAPSALSIAEEIVLPAAAAHGKQQSLLALQQRLKQSWEMSYSDGGGSGRSSRKGSRSPKKLRVTKSENSDKTVTSVSYGHHHHHHHHHRSVEGHQPSVHKRNLYIVSFPLILLFNILRTVIYQLYVIFKYIYASTSHLIYRKHSSRNTCRLEIVVDREAVTNGHKSDIEEMSHNTRRPPGPGPGDPLLAKQKHHHRRAFEYISKALKIDEENEGHKEMAIELYKKGIDELEKGIAVECNGGRGEVWERAQRLNDKMKTNLAMAKDRLDFLASVCELENLEITDDEKPLVVTPRQSDANAERTLQQQQRDKADIKSLRHRRNNAHTLMTNAQTLSDANNSQKQKNNAQTLNTAQTSGRKFPVSGKRMPGSAMNKSQTLPRSMGRSPAVLPCHRPSLIKPSLTPPSVKRQLSVPGSESPLRRRPTTPNNVGVGSAANSNKGTPVRKLPQMKGVEPKLAQVILDEILEGGAPVLWDDIAGQETAKQALQEMVILPSLRPELFTGLRTPARGLLLFGPPGNGKTLLARAVATQCNATFFSISAASLTSKYVGDGEKLVRALFAIARELQPSVIFIDEVDSLLSERKDNEHEASRRLKTEFLVEFDGLPCSPEERILVMAATNRPQELDEAALRRFSKRVYVTLPDYQTRIILLKRLLAKHNDPLTEEELNQMSMLTEGYSGSDLTGLAKDAALGPIRELNMDQVKDMSLSAVRNITQQDFIDSLKKIRKSVSPGSLAAYEKWSLEYGDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F547</accession>
    <name>A0A232F547_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000919">
        <property type="protein sequence ID" value="OXU25911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F547"/>
    <dbReference type="STRING" id="543379.A0A232F547"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="247" mass="29167" checksum="2099444622CEE87B" modified="2017-10-25" version="1">MAFHLNNIIENSINVILILGHQLFCNTLPKDVLEQCKRTLRCLKCARYFSDFGSLRKHMNYVCQVDPLYKCPYCSHRARMNTLLKYHIMREHANKPANKSFPINYSFNTCLNRKSRTQKQSLNTLIRNLGYGYYQTTSSPHQRFIAPSQAKPQTSKPQHECQNCGAVFQLRALLKSHVQLACKRVQRVDVYQCNQCPYRSSYKANIERHVRNLHDRQSTEFKCKLCNFRSKYSYCVRRHMKTFHPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F591</accession>
    <name>A0A232F591_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000935">
        <property type="protein sequence ID" value="OXU25845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F591"/>
    <dbReference type="STRING" id="543379.A0A232F591"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="684" mass="78714" checksum="20D6715103ECA570" modified="2017-10-25" version="1">MGVDEKPTCCVASDVPSSNLYCISNEQSSKSNKSNKSLTSNLIKAFRKTFLKKKDTMLGAILDNQLKEFATVKNIDTMTRDIVEITENVHEMTTLTTALAELSVLFDKVDHAYNLYLYYKDSNKNANDPSLHKFADETRSPYQGPVDYLNTIHSRVVPKNLDVSSDGLGYMNDVSVLSLLTKHMKSFQKICNKSKSQQQILHMLYMSVGVAEMKLYSTLEFCFKKLSEIDECDFAEEIKLLKDQLYVRSNKAANMFEKFMHIASRDVWRCDPKHHIEDVTYTELKEVFQKYVVNDEDMNNENNCKKTCGEFKHATVTNCANKEEHYDTEVQYYEYSICDQQRKCNGALFDCEDYFADYNELWICPSTLNSSRRYQFMEHGSVDPVIFKHDVRQYGPKGDKKKCDRHITYDYREFGQSFKDAWRHCEVCLCTCHDFKSPTSEQQINVRPVVADNDYVVTGARLVKKNHILHVQIQQGKILADGNIDDSTLYWKPIAEPRNVYDLRSFSWNGFRTIYLEVTEVPKNHVLVGLKLTNLKNGDEQMISFKTLSVPYDYSTGELTYDGSYYDEPEKLDLRDREFDPWPKYESSPMSSAAEVSVENCDLPQNTHFPSLPQPDSKKTIKFTTSDFKKDLGQSMIPFIDIQEVSIRPAVPLVGIGFYHKGREGYGGFVGLKLVTFDHSPHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5W7</accession>
    <name>A0A232F5W7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ataxin-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000846">
        <property type="protein sequence ID" value="OXU26224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5W7"/>
    <dbReference type="STRING" id="543379.A0A232F5W7"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="6">
        <location>
            <begin position="420"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="525" mass="59712" checksum="58833E318EF8D407" modified="2017-10-25" version="1">MESSERLALCIENKDWDTLVSILKPKDFCSDIPRTLCDFNKLLKVAELLTDKDFNISEKIKSILLKCLANSCVNGYLEKAYVPNDGGDISAHKNIYKFLSQEVSNWSEEGPYPFHINFPYDGVVRWAIKTITDYASTQKRLSEDQTEVLRLSLQFLCNFFTFAFNISTSTNADVIMEYIKDQNFKDTIIKLVGHDRAPIARAACAYVHNMVKQLFKEFYATIDKKELTAELIKSTISDIQAALDTVILLLKEPNYLKDIYDEISIDDRLYLLDIIHQEVRSFVYNEENKNTHWLPIESIEFLSDKFKKKSDLILKTVNSELNNIEPTEVTILIDILGVLTSNPKLDECKKLQEDKSLLINCVYLLKAIHMVGKDTNNCFTPLQKLSDLALHTKADCCNEAEDPNNHVCKEKIQNHPAFGFKASLIRVIGNLVHKHEKNQNLVRENDGIPLLLDCCNIDARNPLIIQWTTLAIRNLVDKNPENQEVIGKSVKIGVVDSAVVREMGLTLHDEGEGNAIGIMPLPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5Y8</accession>
    <name>A0A232F5Y8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000919">
        <property type="protein sequence ID" value="OXU25910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5Y8"/>
    <dbReference type="STRING" id="543379.A0A232F5Y8"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="11029" checksum="F2973D7D74544322" modified="2017-10-25" version="1">MYLADPLALHPNHLLAPKYRHTVINPGLQCQQCGKSYSHRHNLLKHINHECGGQRHFICSICQMRFTQKISLQRHLRCKHNIDTKRLKRRNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F671</accession>
    <name>A0A232F671_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000929">
        <property type="protein sequence ID" value="OXU25857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F671"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11608" checksum="A37AA70F12FE1BEB" modified="2017-10-25" version="1">MLTFIFDAGIPPSGKNLPSTWSRTAARRREEIERPRSPEATQRPAGHCIRVRVQQRIRKPHYIAPFSVKALGFTRSLVKKVFAREDYRAIISVEFGLSSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6A1</accession>
    <name>A0A232F6A1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_011082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex. The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Directly interacts with CD2BP2. Interacts with HNRPF, HNRPH2, NEDD9 and PQBP1. Interacts with ERBB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000922">
        <property type="protein sequence ID" value="OXU25887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6A1"/>
    <dbReference type="SMR" id="A0A232F6A1"/>
    <dbReference type="STRING" id="543379.A0A232F6A1"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="142" mass="16859" checksum="9B710148F484DA75" modified="2017-10-25" version="1">MSYMLSHLHNGWQVDQAILSEEDRVVVIRFGHDWDPMCMKMDEVLYNIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWTLEDKQEMIDIIETVYRGARKGRGLVVSPKDYSTKYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7E1</accession>
    <name>A0A232F7E1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM50 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_009778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000808">
        <property type="protein sequence ID" value="OXU26410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7E1"/>
    <dbReference type="STRING" id="543379.A0A232F7E1"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="4">
        <location>
            <begin position="203"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="353" mass="41306" checksum="78EED378324108D9" modified="2017-10-25" version="1">MAHYKGAASEAGRAMQLMKKREIAQQEIELRKKKIENDLKIHNIENKFATHYNAVEQQLKTSTIGLVTLDEMKAKQENIVKERERKLAQKAKEKEQEKERALAAKQAEKSKQKNQIKALSFNLEEDEEEEGGAVSDEDSDAKSEKSSVSKTSEHSEPLVKKIKKNPDVDTSFLPDREREEEENRLREELRQEWAQKQNALKEEEIEITFSYWDGSGHRRSVIMKKGNSIYQLLQRCLEVLRKEFSELKTVMADQLMYVKEDLILPHHYTFYDFIVTKARGKSGPLFTFDVHDDVRMMSDASVETEESHAGKVLLRSWYERNKHIFPASRWEPYDPTKTYDKYTISDKKKKDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7U7</accession>
    <name>A0A232F7U7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000785">
        <property type="protein sequence ID" value="OXU26523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7U7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011968994" evidence="1">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="139" mass="14998" checksum="E5F79EFF374E1319" modified="2017-10-25" version="1">MQFSQKKVCLTLAFFLVAVSSASAKSLQKREANQLESYDDFLNAIDNLRNIPFVGSVIAPYAAVAKGIIQNLDNAVDGNIGNIVDSIMPCKFNGPFARCEGKFDTASARKIAKKLLGLIPLDSMPDSVSSVIRLATNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Z8</accession>
    <name>A0A232F7Z8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000766">
        <property type="protein sequence ID" value="OXU26620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Z8"/>
    <dbReference type="OrthoDB" id="6767894at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="781" mass="90567" checksum="21625EFBA8D3331C" modified="2017-10-25" version="1">MKTVLLQPIYCMLNFLKFDVLWMMSHFLKITTPMWVGFNSKILKDHSKQQKVSYLTPINKSPTDKSVVIETMRRAIAISNQLTYDLGIAQIAMIIQSEEKEEFQNPFIHLVGTFIDGCGLTTILIEAELLGSGSEASFINGKIYTRCKKLHVLAVISLKILEFEFFLDQKNITLDDEMKQYFNTLQNSELDGMKIENSNVNHLIKQFLEFHKEVMLGYYGKTAQFYAQYITLIKYYLIFDLSIRMSNFELYKHIIPKISNKLCPFARWLTFYDDKLLNIDKSHPGLKNQLLIGVKRTDKRFSRVPVNLTLEQTVNAECGRRLTGISHLNLLKNRIEQSKRHIQKFIVTLKNRMNPFSYDHSKDMLLNISTGEADPAEIANFLHNIEKIGEDKRKKFIDCSENENNFSKYKIKHTKILNFEMMSKKEKINVAGKVQEVKLQPDLFGRLLAISLEQDIDLDKILTYPLTPFRWKYYENGQVNFNQIIGIQSANQARPVDFNVELRNVKFKEAFVASLIEHWSSDEIAEIFVEKEIYVSFKSCHKYIAENGKIYRTNLSDRSCEGHVEADTKFALFLKFVCEMYATTKNKLRNVKKVNEARSCIFGQSYGMIDDMEAFKKKVVSFDASNLSPCLRELEQQILRTAYVPNIWINAHKNIPSILDPTNYGWSLNNDGEYTFKWFEGPETPETVKEIIMPSENSQVESTKNSIEEFVCEIYATTKNKLRNVKKVNEARSCIFGQSYGMIDDMEAFKKKVVSFDASNLPPCLRELEQQILRTAYVSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F870</accession>
    <name>A0A232F870_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulation of nuclear pre-mRNA domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Associates with the RNA polymerase II complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000678">
        <property type="protein sequence ID" value="OXU27034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F870"/>
    <dbReference type="STRING" id="543379.A0A232F870"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16981">
        <property type="entry name" value="CID_RPRD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000020">
        <property type="entry name" value="regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF40">
        <property type="entry name" value="REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="720"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="173"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="898"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="949"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1011"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1033" mass="112567" checksum="57500DE696CAAF48" modified="2017-10-25" version="1">MVSNDFDQEQFERRLQSLKDSQESIQSLSAWCLERRQHHKKIVATWLQVLKKVKVEHRLTLFYLANDVIQYSKRKNFEFVESWGTTLQRATTMVRDEKVKHRILRIFKIWDQRQVYDEEFLADLSGLISAAPKKKAEPQPIQQPEEFQAALLISTMRSCATLETATDARLRDLRDSNVDIDNAEELCASLKDRRRVEDAEKEVDQAARNIENYVRALEAEIRERKQVLDLLEQADQFYETQRGEVKIVVNAYKNFGSRVKNLKKKLDELVPLLASPIPSPDINAPSPSPDSDIELPEESQIDQSSLINVAPPSMYGSYGQDYNPVTAPVNNTTADFTNNFQSFMGGNLEFDPRNIFNEGSVASGNSQQYDSIENKSIEVIDVHPAEVNNDEPVSSFLKTVLPSSDATSDSCGIPGLGLDATDGMPEPIPCNDYRPSIIGQMPSTPVMSRLMGGPLTPMGNVNNIQLGHSTPLHNRSLNGESHTPSPYSSENSQNPSTTVNSFEGAVSNVNPLQPPPMPPIEFLDDNNCYNKLPPKFPTWTFANDTPKEPPKWEEKVVFPVHNDTNPIWPVNDLKMKNSWNETSNEQWDMPNEPSWSENSRTKDEILSETPESPPMYEKTAFNEPVEYNDSQSNEPILSSVGDVDHRVLPMPMSMEKQLPHRLMKGADVDHRNLISLTGSPANNSNDGLPGPLSNNNLWTNTDQDYRRPVQIGDIVESVDMEMSDEEGEGKKSNRVLVDLRSQDRDMRVPNMPPGPPPGPPHHHGGGDMDMRLMSGPGGSGGPGGPGGPGGPGGPGGPGGPGGPGGMNPMHNSPRGGPNLGPGPGMGPGPRPGLGPGLGPGPTLGPGQALGQGPGPEMRGVDVRPPPPPPPPMPFHQGQSNFPPNQPDFRHNKSMDFRPNQNFHQNQSDFRPNQSFPPNQSMQDFHQGPPEFEFFDGPLGRGSSMQRGGMVSGRGSIGPGIGQGMGGGNGGGVGGSPFRGGGGPRPPWMDRGGPGPRPMTISGFPPSARRGGPFGGRGTSGFRGRGRGGGGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8C5</accession>
    <name>A0A232F8C5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000744">
        <property type="protein sequence ID" value="OXU26719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8C5"/>
    <dbReference type="OrthoDB" id="6514900at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="225" mass="25290" checksum="911D68B352BBE12B" modified="2017-10-25" version="1" fragment="single">PKTFVIEPLIANTDCEKATGEQLQPPIALYTEEENRYERLKRMSRYAASAVAVAGIVLCVVLLVQVTEARPSALLSRPKRVSDQRLAELETLIALQKMRGKLVTVPIGFGKVDPMKILSPGNSRYIRNGEIPDLSLCNNSRPDSSSAILDSGTLPYRRGRKRRSSTETSWQELSRILRSIVEEDAELSPKDRIRFARLFSSRWDEVRNQDDTPTANDRGEDGALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8W8</accession>
    <name>A0A232F8W8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial basic amino acids transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Carnitine/acylcarnitine translocase-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Mitochondrial carnitine/acylcarnitine carrier protein CACL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ornithine transporter 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 25 member 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSAR_013830</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Alberta</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) = L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:72807"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:72799"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:143006"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-ornithine(in) + L-arginine(out) = L-ornithine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:34991"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:72803"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:114953"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000694">
        <property type="protein sequence ID" value="OXU26940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8W8"/>
    <dbReference type="STRING" id="543379.A0A232F8W8"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005289">
        <property type="term" value="F:high-affinity L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000037">
        <property type="entry name" value="Solute carrier family 25 member 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF61">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="10 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 23" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="85"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="22">
        <location>
            <begin position="183"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OXU26940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="371" mass="40836" checksum="46EDF0CBE9DCD2F6" modified="2017-10-25" version="1" fragment="single">CAGIVVGYPLDTIKVHIQTQDHRNPKYKGTWHCFRTLIKQDSVSGLYRGMSSPMAGVAVINAIVFGVYGQTQKFLNDGLPPNSDHQLGGHFLAGASAGIAQAPVCSPMELAKTRLQLQDHDSAPRNGNQPRFSSPVQCLRHIHRTEGLRGVFSGLGITLMREAPSYGVYFVTYEALTRSEHPISTWHMLLAGGLAGTASWVVSYPLDVVKSRLQADTTAKYNGALDCFRKSVRNEGYGCLFRGLNSTIIRAFPTNAATFAVVTWTMRLLGEDQPRKAPATQPKKEEHELFKPSSRSWNAFDRYGESSCQSLHKIGDATNGYLHQLMNASLVLMPHASATAGNEVAAVAKTASVKQFDEARHFEWAREMVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F997</accession>
    <name>A0A232F997_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000611">
        <property type="protein sequence ID" value="OXU27406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F997"/>
    <dbReference type="STRING" id="543379.A0A232F997"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16869">
        <property type="entry name" value="ARID_ARID5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF44">
        <property type="entry name" value="ARID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="255"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="844"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="970"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1260" mass="137143" checksum="84A3BD5D13FC00B5" modified="2017-10-25" version="1">MKSRGKRDDEVLTISEKVVVRVHDLVTWLSPSLEWSWGREVSLPPTPSSSPDSSPQPQILSDPGLDFSDVERHQKDLDALTTSTRRSEPVNQTKVVVLSYPRYCRYRALLRRLEGSESSWLCSSVAAALGGFTATSGTRVLFCRDTFDYPDLETHELLCNHLVGFPKNNSGRYLEESFLEMRGLTEVAPKLKGRPRRKRKKRSVSPAGESSNESEASVASSAAASTSKGSTSSSGQSSGRPSAASSVRRSERKVSAEEKRFLDDIYGFMSSRNTPIGKMPLLGYRQIDLFLFYTKVHELGGYDKVSLNRLWKTIYDEMGGNTGSTSAATITRRHYERLLLPYERYQKGEETKVRPSQGGRRAKTPSTSDVSEDSVEVKRENESPPPSVTPPPSEASNSTATPPPLQSILSTSPFLPGDKPGKTSSLRSVRVKPERLKSLNTIIATSNPVQPANQQQLPSSPTSASSPTSTPPAPTTPTNPSAQHSVLERQLNSPLITHQVPPACSPPGLPVSTVATNATTVVTLTPPPEKDMKEIKLDPKQTSLLAQGKENIPLFEEKSAIFTDKTLVAPRSPEVIDLETETEPGTRDKLIIPSFKKRKLEILREGGLEVTAVDLVFINPCYRCTAKCDPTNCNDVVHHERIFFSHNDYQYNIVPPMRQEDGRSSTSPDFALPQPAVIPKLINVTVTPDIGNIMPRSSESPQQPVTPVKCQPNSLPNSGESPTGLQTSPTANSRVINLGNNSNNATLLQLYANANVPVPHSLAAAAVQTNNHRFVPPHLPNGRPPVPHKVTQSRSIFGNNEKMVYGNPKDILVAPKFVPAMVTPPHIPRAPSILSAPNVRCGSSGSSMDANTSGVLDLTQKPSAPNERPTYGRPNLEIVRVPVVPRPTPLNLETRNHHQYVDHQPHYPRISVASNLCKEVNTKPPAQSQAERKNQFVTGSVPPSPVGYANVLDSRTMATNNLEITLVSPKKTAVGNAGPPQLSPPLRNNNVMPPSVPVQRRQQQQQHLNGKFPTRLPAEPVSPYTPRKPVSTNSGPSIQHPVIPNIPNLSHLNAGSSSNYGKSNHIGNYQHMAIEKRRAAEAASKEHQRRTSESDKIALQLQQQQQQQQQQRLEATSATLSKQQQSRDAETSRRHSVPSIPTGFIPTMPASSPFPYLAHQLAAASASNDSSSSSTAAAAAALDVANFVPTLDPMYYSAFYNSLFARPMGPARAAPNAAFLQPEISAYCKELFASSSAQQTRLAMAAAAGQQHQPAAPTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9L3</accession>
    <name>A0A232F9L3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000583">
        <property type="protein sequence ID" value="OXU27554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9L3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6603" checksum="E8D77B179BE8EC66" modified="2017-10-25" version="1">MIWVKQLKSVLVALEKSKESLGLILKKSRNVTEPAAYLEGEQGITDDNSIKRSEDENAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAE9</accession>
    <name>A0A232FAE9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000604">
        <property type="protein sequence ID" value="OXU27429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FAE9"/>
    <dbReference type="OrthoDB" id="7701719at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1257"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1414"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="1623"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1711" mass="196402" checksum="6FFC7FF5C08EF66B" modified="2017-10-25" version="1">MNVHGRDRKFNKMTRVSLKKSNSKNEKICIKENSTRNISNYLGKKLRNSCEDNFISLNLRNVSPVNNKQNHEEVKNQSSLGKSEITKKKIVPDKVQDEKLLVSPIVLLEILSEDRIKKTTVFEKINVPTNSASFGTTKKSSHRNLRKYVRNKAEIQDIFGKCIPKFISEMYTYEQIHERVDKIRVLEVEIFKLRAHLPDQLFLVLWAVWIFSVLNSHKQICISKLESNANEKQTLANKSIGKSSTRFELKISNNPVLDERIKNEDTDDPKVKLKNNEVFIVKETVCPLNKNVECDTKKERHLKQQIEDKQEYFNQSTTNIQENSTHRTNAKISINCDEQKNCKDKNMPTVNEIIKDFTKDEQIIFEKKCAIDSTLSEKSQNLNECFTEYELCINKLNKDLLDSRVNNETSIIDDKSIESHGNEQIGEEIISDNVVNDTCNDDEDDEEIIFYYINSANEVVKKVDVKRKSSSKVEKIKDDKVMCSIPPAVDNCLENISVSQPAINNSKVIINVENQNEKDGSKKTINTDKIVLTTEEKDVTTTQSKLSVKNKTLDDKVSKMEKPKIIDIYQPTINKKNENMEVNVRETIANNDSIDIIQPINTNSVAKIIVNQTADTTKDKTIINNETFTREKERTINLSQPTIIKKSNLVNINLPIVVYNSENMEVEHCVVIEKDQGKNVYQSEVIDKTDAINNEKTTVHKKDAVVTINHTVNSMKNIKIIKETIVREGEINYINSPATIDKAKTINLKKPVISNVGENIDVNQLVTTENNEILNIDQSVYTEKYETLNTSQAMATKKNVLEKYRLIIEKNENLKFKQSAVNERTDSIEINHIAVTEKNKTNTLYKLVNTEKDKCITIESITSESDEIPVVGQHMASGKDRKMKANKPLITENEENTNFNRSLIIEPEQNIYINQSSIIENEKNKSSNQLVNDENIICIEIHQPQITQQNKIIITKKLTSVETNPATVNETDLVDKIKVEEIVEVGTDQIADDVNLHKINGDITGESIMSENIKVEVVDIPEDNIDTEIYLDNDAISNQYTSINAVSTQDIRESDTLTASEDERNDASIRAYDNDENNHEQHEDSVLDSESTNDESMDRSKAMFINFMEAYQRMKRDIAVNSLLSLNGAFNDANYADIGSEILHISDNSDNEDTVVEKEKEDILAIQKPSTVAAVTPVLSINPVNSVNLVNPIRRKILLPNGGAVISASKLYGCGDGISVKEENERSFPCPNCARVYKGETTYRKHKKRCTEEPVLLPCILCLKKVKHKRSLVEHLRRVHKNQVMDHEIKEIVNDVVKEAKFRKNTKTPIASSIIELPEYVKLFCNRCGKIYDCVDSSYYRECGTCSVSLLIFCQRCDTRCVVSPRISIHLNGDCKVGEPIKCPHCDFVSSQRHHIYQHIEDAHKAVPLAKEPMLCNKGCGRKFDRDLALRRHEKHCGTKPNLRCKFCKYKTRHRSAIKMHMQQHVLRNDTKLFERSFSDSDTSDSNRTPALEVDENSVRNLMKAYCSTCKVAVPMPPRYVHDCITCRTRLTYNCNRCYLVPSRSHDYRHVRVHVIRCHAEKVYKCSSCNRRFAYYYDYNYHKSNCDKNMSFRCNLCPYKSNMLKGLQGHMRRIHPNGLVKIHRCSQCSKNFSTKDTLQRHLRLYCGVEPNFSCAHCEFRTKSKFSLIRHIQNKHSEIFEHCRFQCFHCQKVYSNLYAYETHVTICPEKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBK4</accession>
    <name>A0A232FBK4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Catenin alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000532">
        <property type="protein sequence ID" value="OXU27838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FBK4"/>
    <dbReference type="OrthoDB" id="6376697at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000007">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000011">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF9">
        <property type="entry name" value="CATENIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00663">
        <property type="entry name" value="VINCULIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1089"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1089"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU27838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1133" mass="126498" checksum="E43FD6F00C1AD20F" modified="2017-10-25" version="1">MSDHFGPITLKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNTKGPSKKKKGKSKRASALVAAVEKATANFIEKGEQIAYENPDITAEMISAVEEVRKTGSAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRLLILVDMVDVHLLLKSLHVVEDDLKKLKNASSQGELLENIKQFGINATELMNQAAKRQQELKDPQLRDDLAAARAVLKKHSTMLLTASKVYVRHPELAAAKANRDXIEKGEQIAYENPDITAEMISAVEEVRKTGSAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRLLILADMVDVHLLLKSLHVVEDDLKKLKNASSQGELLENIKQFGINATELMNQAAKRQQELKDPQLRDDLAAARAVLKKHSTMLLTASKVYVRHPELAAAKANRDYVLKQVCEAVNTINDVAQGKTPGDTQHPYDGPGELAAALDDFDERMVMSPLAYNEVRTRPSLEERLESIISGAALMADSSCTRDERRERIVAECNAVRQALQDLLSEYMNNMGVKEQSEGLERAIDHMCRKTRDLRRQLRKAVVDHVSDSFLETSVPLLVLIDAATKGKDKEVEEYALVFTEHANKLVEVANLVCSMSGNEDGVKMVRYAAAQIEDLCPQVINAARVLAARPRSKVALDNMEVFRQAWENRVRVLTEAVDDITTIDDFLAVSENHILEDVNKCVLALQEGDADTLDRTAGAIRGRSARVCNVVQAEMDNYEPCIYTKRVLEAVKVLREQVMPKFAQRVEVAVDALGNNPPKDVDENDFIDASRLVYDGVREIRRAVLMNRADEDLDPEDVELDEHYTLETRSKSSAQTGEHGVDEYPEISGITTAREAMRKMTEEDKQKILQQVEHFKSEKLKFDREVAKWDDAGNDIIVLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEYGTKLDKLTRQIADQCPESSTKKDLLAYLQRIALYCHQMNITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTKYPRQSTVTSPIVVWKMKAPEKKPLVRPERPEEVRAKVRKGSQKKVQNPIHALSEFQSPTESSPIVVWKMKAPEKKPLVRPERPEEVRAKVRKGSQKKVQNPIHALSEFESPTESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC69</accession>
    <name>A0A232FC69_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000489">
        <property type="protein sequence ID" value="OXU28038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC69"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="81" mass="9754" checksum="DFD97F6A78FD5AE4" modified="2017-10-25" version="1">MRLEYGMKITQDCTTICTFIKFYLKDVYLQDVYRRFYMMRLLGFERRARAITFLFHLSTTSTIIHGTKAALERDLQLHCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD81</accession>
    <name>A0A232FD81_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_003283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000384">
        <property type="protein sequence ID" value="OXU28764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD81"/>
    <dbReference type="STRING" id="543379.A0A232FD81"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU28764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="353" mass="38676" checksum="5594C9BC854C4939" modified="2017-10-25" version="1">MSFSQTAMVKAYSGALVIADVLLLLLKVLYCILEGVYRFFLPADEQSVAGEIVLLPNKSVMLVAKINRALRRRSQQVTGAGHGIGKELALKYASLGATLVCWDINDTNNEETVDEIKKMGGAAAHGYKCDVSNREEVLRVADKVKREVGTVSILVNNAGIMPCRPFLEHTAAEIQKMMDINVMAHFWILQAFLPDMLAKNHGHVVALSSIAGIVGLTNLVPYCASKFALNFFTLLKPAFLGREPPGLMEALSEELRISSSVGGTKSNIKFTTIYPYMVDTGLCKKPKIKFPSLMAVVPPQEAAAVIVRAQRRNVPELSIPSHWLGVNYFLRNFPDKVPRAIKDFLDSGVAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD91</accession>
    <name>A0A232FD91_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000427">
        <property type="protein sequence ID" value="OXU28480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD91"/>
    <dbReference type="STRING" id="543379.A0A232FD91"/>
    <dbReference type="OrthoDB" id="6110560at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="17280" checksum="9EF1887603C9504A" modified="2017-10-25" version="1">MSCKSLLILQIVTFVLLSCFFETGVSIKCFTCRSDSDPKCADPFNNSTIQIIDCQRESEISPTVRPNMCRKTRQKVNGVWQYYRGCAYANEHSREGDGKCLWKTDTDNVSVETCTCGDKYGCNSASEHHYNAFLRYGGLFTTFFIITSFLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDA1</accession>
    <name>A0A232FDA1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_015833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000426">
        <property type="protein sequence ID" value="OXU28490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDA1"/>
    <dbReference type="STRING" id="543379.A0A232FDA1"/>
    <dbReference type="OrthoDB" id="442860at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="291" mass="33667" checksum="8545B3077DB258E5" modified="2017-10-25" version="1">METVRPCGCKGIRTCLICENEYSISKPDLAADLKKCPNYVYCPECNKAWPGWDMNLYKQHPRHSGVPIEFPGTYIKLDFLNQDELKSLVNSLDLLPWEISQSGRRKQNFGPKTNFKKKRLRMGNFIGFPESTKFVQDKFNDVKELKNFQTIEQCSLEYDSQRGASIDPHIDDCWIWGERIVTVNILGDSVLTMTPYRGSSNKYNLDCVESLQNQAAPEQNIVVRLPMPEGSLMVLYGAARYSWEHAVLREDINSRRICLAYREFTPPYLPDDKGDCNEESREILERALNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDB1</accession>
    <name>A0A232FDB1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000425">
        <property type="protein sequence ID" value="OXU28500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDB1"/>
    <dbReference type="STRING" id="543379.A0A232FDB1"/>
    <dbReference type="OrthoDB" id="6379191at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601823" evidence="4">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="143" mass="15309" checksum="1D3C69C290BF692F" modified="2017-10-25" version="1">MRFAFFVANHFGKSFAFVALFALVAYASAAPATSDEPIPILRRSDDGPNPDGSYAFSYETGNGIKAEEHGELKPGGEEGIASVSGSYSYQAEDGTPIEVKYIADENGFQPQGAHLPVGPVIPPGILRALEWIAAHPEEDNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FED6</accession>
    <name>A0A232FED6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid-binding serum glycoprotein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000346">
        <property type="protein sequence ID" value="OXU29032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FED6"/>
    <dbReference type="OrthoDB" id="10486578at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511543" description="Lipid-binding serum glycoprotein N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45390" checksum="3C0AEAF80E58DC5F" modified="2017-10-25" version="1" fragment="single">MRGNRISISVLLIAVFATIKTSSAAYEVINCSPKNLTFDIDSTHKVNLNNLSIYFKYYRDNVGIYQYPGTPSVNLFLNDTEISIKGEIGSNNVGLNINNDKLLSTEVLGIGNIVNVSDHSKGLKDCAFFMLDKSSGSFFNELPLKLDSIIFQLVESCLSAKLCPSLGAVRDNDLARARVSPRDFGPMSVWSRTLQISYPKMISPQLPENFQTNKRANLIEAADSIIRMVAEAFYNERNGGIIAIPDIKHRFFTASKGTFTGVQNLMRDENVQVRASPPSKNLQTFTFTFGIPDGYVKYGDYKTFRLMPFVGSLCANVQDILFTATIQMDFGQEYCRPSLVDFGTKSPGKAESYTCGRLSMFTNPIMKWFVSAWDTDVVQVVEREIEWMMAAYIHDKFDCENFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFK8</accession>
    <name>A0A232FFK8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_007474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000320">
        <property type="protein sequence ID" value="OXU29238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFK8"/>
    <dbReference type="STRING" id="543379.A0A232FFK8"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010542">
        <property type="entry name" value="Vert_HSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06546">
        <property type="entry name" value="Vert_HS_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="57"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="769" mass="85340" checksum="7F2E3B24DCC63F2B" modified="2017-10-25" version="1" fragment="single">SKLRQQQEATSRSQRKLPTRRAAEEVEDVSSSSSSGSSTAGQEERTGMHTITEMGTSVPAFLGKLWRLVEDPETDDLICWAPSKELLGFCCRQVDISVVLAGSIARWRKTLTYCHSKCLTTVEGVSLLGIKPSLHGSCYHIITSTTIWLVLCANGFHKKVSVELGGLKCDRDEMEFAHQYFCKDHPYLLEHIKRKIASNKTQDPSQAPIKPELMNRMLTEVRSMRGRQEHFDSRLGAMKRENEALWRELALLRQKHHKQQQIVNKLIHFLVSLVQPNRNSGLSMKRRYPLMIDDPSRIQERLKHRKMSKVQRSPTGPAIHELDSSDADLESDYIVAEMLDNDQAPMIESPEHQSVAEENMSEYYIDEPVQLPQDIEVCQNSHSSKKRFKGKKKGEETLLLEVPELDKVMPSPSSATQVENSRPTSSKPIPLATVRSSKLAAMAANMKKNQEVELDLDLDKYQATTETEPKDDSIIKLENILIVPDIMNGEYNQEPDESNGNTLPSSASSLSGNSAGSPIEVLQQNSPDAADVNNGSFGNLDFMTTGTAGNQTTTSMVNQDKQSPLSTQQQQQAQQQQDKNMSLSCVNTSDANFRLGSMEEVDTHLDTMQSELENLRDILRGEGYSIDANTLLGVSNFEKNLFGAEDPMSFGIPVNPDLDPHSNQEKDNDDDNHLNAAEQSDPNRKGELMTYSATPSLLDFDDDIFLGTSSSSPAPAVTDVANTGLSNDPLELSDNKGNIFDSLIAANTSNSPQSQKPSILLKNEDISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFL5</accession>
    <name>A0A232FFL5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000302">
        <property type="protein sequence ID" value="OXU29353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFL5"/>
    <dbReference type="STRING" id="543379.A0A232FFL5"/>
    <dbReference type="OrthoDB" id="7692612at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1237" mass="138716" checksum="DA29FECC2EFF2B50" modified="2017-10-25" version="1" fragment="single">MLFVYSFTYKVALDVPLAPGSRADTHTADNLKYFIVHTRTVFSCIEVHQKTSEMASEMKLLWVLLLLFTTAFCDKKLNLEDIEKDHIRSDVKNSGGKKTTKDTVRNEDSKYLLKAEVSSQSQQQYHGPPAPPQELGNQVGDYAELQSYGSFKYATQPYEYSQDNYQQNKNAVTYLQHGSDLVNPTEHYQSEQQQYVQEGRSNSQNDYDALQQQQQFYQQKVLMGNQLQNMQQEAVAHKYIEKNQNEGVYYMNIPSSQILSYYQNYGMAQSNNKDSEQQISIPIYMPAYAQNQTPKGVATSSHTSTSAASTNLAQQHPATNQHQHTVPIDAQGDEAYTSVAYKPQKYEYYVTQQQLSQPRFVHQSKQPQQLVYENSGETQESLHRDFSPLQYQAQKFRASHEVTHLAPVDSENEGFHSKPIHSSASVLSQPKTLLDSYIPSHVIAAQDANRYRERPIKLESGFLPSKINFIRSLLILASCVVAAPKAITKTKDGVEDDNYSGDEDVPKNHRKQLEDEIDLDDAFDAEQLKNEQLPILPPIILLDFVNGTDDNNSTSSGDEKSKRTIDGSLGYGFNQNSLFSGKHNFYFPAGKTGTAVSIEESISLAPKTVTEIEKPITEETDANSPQNEQEKKTREPLFEALPDPLPLENGREPPPLYPPFPMFGQRTKLQKTSSSDFGQYQSRPGTKQFSSSYATAVTPGSETYNKLIAAYTSMKPAAYHTGSSSFSSSANINGYARPMTSSYLTNYMPDIYSSRTSQKSSYNSRPMPSVSAGSNQEINFANYPRYTYENGIKYEHKIVWKYPDGKISETPPISYTNSYSEYSEQQKINKASINGFRPSTPYQPRPGNSQQYQRIQGSSYNPSLANAQNNIYSQRPVQFPKDQEQQNPNQPKEPSRIISHSSGSASPGNRVESASPYNFASYQGQYGMKQSPKPAGYRVASGYNSPYNNQYVNSQSAPKYSVNSPEADYTYESLQGPKENLFSANGQINQQVLSKYSPEAQQYLKKVFDNAKTSPKFEAHSNVPAGYANTDYSNLLNYNPSISQYIKNPSSILNAQPTFIQAGNSLIPVIILRVDGAPPIQPKVGSNINLKSLLRQYLTQYAKSVSSVSQNTNYDLGGSINDGEVSASQPNPVEDLKQLTESLASLRQRGHQDPDFTTSYAHTSTYEQQSQHQHLPQQSQSITLGQDYSTSYAGFVKDYQKIHAGQQGRKSQTVKSVQIIEDPRIQEKRVVLLDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFQ4</accession>
    <name>A0A232FFQ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000281">
        <property type="protein sequence ID" value="OXU29525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFQ4"/>
    <dbReference type="STRING" id="543379.A0A232FFQ4"/>
    <dbReference type="OrthoDB" id="8902093at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="315" mass="36252" checksum="6C495E529E7DA50B" modified="2017-10-25" version="1">MQQSTARRSSSMTSSSGSHVVYHHAKFRWTENLTCRFIQLRKEHGNMFTGRKYSAQAGWEYILRQMREEFPSIMADVHYRVLKKKWSNLLQQYKELKNPVHGDKNKADDISWPFYAAIDEVLGGTSTPSSEPTRQPSDDEEEDEEEELNPQEFLCVSVDNDEDEDDASVNFYQGSTSKVPGLEPLRRGHVFDIERTPRTATRRSSSSSSKTNKRAASDLLSRLPRATELTIRPIRRSSSELPPLEPIATAAANGRSRKRARTTLDDQRNDEGSRESKLERKIGEFLEYAKKRDEENRNILLRMLEAVEDIRKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGM0</accession>
    <name>A0A232FGM0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000221">
        <property type="protein sequence ID" value="OXU29916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGM0"/>
    <dbReference type="STRING" id="543379.A0A232FGM0"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22384">
        <property type="entry name" value="KH-I_KHDRBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000052">
        <property type="entry name" value="Kep1, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF42">
        <property type="entry name" value="QUAKING RELATED 54B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="400" mass="44382" checksum="C7338B18F0E7954A" modified="2017-10-25" version="1">MKKKKKKIHKTQSSGKPNKDQKYVDIYREKPIRVSVKVLVPVREHPKFNFVGKLLGPKGNSMKRLQEETMCKMAVLGRGSMKDRQKEEDLRKSLDPKYAHLSDDLHVEITALAPPAEAHARIAFALAEVRKYLIPDNNDNIRQEQMREMELTVDEPIEERRPSARGGILRPVSRPGPPGPPMRGPAARPAILPPPPPSRGPAARPIPAKTKVFSILDRARVAMDQSYGYDSAPPAPPASRSSHHDYDYHGSSSSSRYGSGDRHYSSSNTDDMYPPPPSSRYAGGGGSSYDYEDDAGPPHSSSHDYYDAPDYPGVQTIVAEGVGALSCDLKSWCPIEPWTIKCYDKDIFVAGERFSCIPEHQAMKLLQKHRGAAQQTKTVPRKNGVTLQNSRSHTAERDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH11</accession>
    <name>A0A232FH11_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_012333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000245">
        <property type="protein sequence ID" value="OXU29748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH11"/>
    <dbReference type="STRING" id="543379.A0A232FH11"/>
    <dbReference type="OrthoDB" id="10044490at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051751">
        <property type="entry name" value="Immunoreceptor_sig_adapters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098">
        <property type="entry name" value="SH2 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098:SF14">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="558"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="675" mass="74943" checksum="EB1EB2142488D088" modified="2017-10-25" version="1">MSRPMSRRAEVLEDIAGWSTDDVVALLQKNEVDEACWKAVQKRQIDGDELLHLTEGKLALWKTDLTRPLIWSLWSFVEELKKSPEKYVEDRHYRPTPPPAPPPTPPLPSADEAAHQPVLAPSSPRELTKVEQQDVEALSDTGSWDTDFEDSVDDEPAESSGAEMPPIIRTTNPAFRNSLRIFQENDRIKMENDARGSSQSLNHIERDIKAPSESEPAPIIESTYANCGAADSESESTYANIGLAANSPAPVSTTKNTSKLHSNGEPQESLAEKLRKQLMLRGAATNSNGKPAVAPKPEALNKSFLHKSARIVNGHGNVQSRRSTFRLLSPLRFYVTHRMNRNFPGKVNPPPKSEPTDKSVNYLNHQNNNNNNSTENSLKNLPKPPVSIRGFDLVANLPTTRVVDESEDDEEEYEAFDEQIVEQHQRNSIIRADSGQSLSTGSGSARPSSVESVYLPPVSTGHEDEEVYEIYESITESPDENGRDYKSESNAKNSANPPPLPAKPPPNITTVQNNLNKAVSVSERSLDKKSATLPHAGSTTSLNNAARPLPPPPDKQSYYERPWFHNLTRDQANSLIERQCTTGNGTDGYFLMRPSTTNPNNPLTLVLWCRDRVYNVPVRRRLDNRYALGSSKPDEQSFASIDEIIPFYKREKLVLYTGGVQTGSTSLSDTPPKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJB1</accession>
    <name>A0A232FJB1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-like protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJB1"/>
    <dbReference type="STRING" id="543379.A0A232FJB1"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038899">
        <property type="entry name" value="METTL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108:SF0">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32973" checksum="87FF2998DA104683" modified="2017-10-25" version="1">MTAHKITSEVFAEKDDAETQKEGNIYIDHFRRASGAVSKFFFKYPPHMRKNRTAGKEALVYDEDGDLVLDRIEEGAILIEHSVATELKLVGLQIWRGALLLGDYILSHPEVFQNKTVLELGSGVGFDSIIAGTLAKEVVCTDVNLGGILRLIEKNFQRNKTLVKSKVCVTELDFLSENWNATLSGKVKNVDVIMAADVIYDDKITDGFVKTLAKLLDTAGARQAYVALEKRYVFTIADLDSVAPMYEEFLRCLRRHKVNWSIEEIKLDFPQYFRYQRLSQLTLMRIEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJU3</accession>
    <name>A0A232FJU3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoglycolate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000114">
        <property type="protein sequence ID" value="OXU30853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJU3"/>
    <dbReference type="STRING" id="543379.A0A232FJU3"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000163">
        <property type="entry name" value="Pyridoxal phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF93">
        <property type="entry name" value="FI11325P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01139">
        <property type="entry name" value="C2.A:_Pyridoxal_Phosphate_Phos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00039">
        <property type="entry name" value="phosphoglycolate_phosphatase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="70318" checksum="34671ABF60E3AA60" modified="2017-10-25" version="1">MEIIFHRTMAAVNLKSLSSKEIIEFFDSFDTVLTDCDGVLWMEMTPLHQSAEVMNTFQELGKRVFYVTNNSTKTREEFAEKCKLLNFKASEENILCTSHLAANYLKNISFNRKVYVIGKSGITKELEKVGIAHCGTGPDPMGDDLTTLLIEKDPDVGAVIVGYDEHFSYPKMVKAASYLADHDVHFIGTNTDERFPTSKSIVMPGTGSFVRCIETCSERKATIMGKPEPYVADMIKQKYNVDPKRTLMIGDRANTDILLGTRCGFKTLLVLSGVTHLEEVEKWKQSTRQEDRDLVADYYIDTLGDLYPHLQKLKKEQKMAACKYLKDLSKGEFRKFLESFDVVLSDCDGVLWREHDVIEGSPETVVKLRELGKKFFYITNNNSKSRVEMLDKIRSHTYDVKLEEILCSSYLAAIYLKQLKFNKKVYLVGSEGISRELDAQGIEHVGLGPDVTEGDELDILFKFKPDSEVGAVVVGFDRHFSYQKIVKAATYAYDKNIHFICTNPDVERPSPNTVRYPGAGCFLSAIEKIAKRNAVILGKPEPFVSEIIKKKYGVDPARTLMIGDNLNTDILLGQRCGFTTLLVMSGITTPEELASIKKNPKGSPILPNFYADQLSDVLDCLSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK25</accession>
    <name>A0A232FK25_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nuclear hormone receptor FTZ-F1 beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_002611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000110">
        <property type="protein sequence ID" value="OXU30890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK25"/>
    <dbReference type="STRING" id="543379.A0A232FK25"/>
    <dbReference type="OrthoDB" id="5984981at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07167">
        <property type="entry name" value="NR_DBD_Lrh-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06930">
        <property type="entry name" value="NR_LBD_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000037">
        <property type="entry name" value="Nuclear hormone receptor FTZ-F1 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF25">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="420"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="639"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="595"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU30890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="95042" checksum="AA3CEA4621C7013E" modified="2017-10-25" version="1">MSTGKSVCKYLGGQNGVTVSVVSSCGANSSGNGSIINTTSNNSLIGADSGSGESASVDDVDGDSDGEVSRIDFRGVNLRTKKKRDGAPGSLNNSEDACGANDSVHQQPERPMSWEGELSDQEMSSNTITNQDHEETSMEGVQVCSSSPGPQEQKFPIKPEPDFRSSPGPMQSLGSNSLNETIVAVSHVQQLHHGHHHHPHHQQQAHQQQQQAQQQQQQNLEQNQQSDLPLLVGKLLGGCNSSTPNHSPVLIPRHHLTKHSHTRSQVPSPDSAIHSAYSVFSSPTQSPHAGRHSALGPGSPVPSSSLSLSRHSFNNSTSSLSLSLSHSLSRNNSDASSSCYSYGSLSPPTHSPVQQRHAHHQQLQQQQNALHLQAGVAHHYGASAGLGGAADAGDAHLDDQDDCRIASAPSGISTRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCLRGAGCPVTVATRKKCPACRFDKCLNMGMKLEAIREDRTRGGRSTYQCTYTLPANLIGGNGSAQAGMGPDKMGQGQGPCSPAPPGSEHHHSMKHHSNHSHKMQVVPQLLQDIMDVEHLWHYNDNDRVGASQAMGSLNLSQSLPNSGMGNSPDGNGSRADSLGGLSSSNGLGSSNPTTNGNLSSRSEPVRPASSNSSTPTPSHEQQHSPPSSSAAGSNNTANGNPTQHPDFLSNLCNIADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSMSTPGEIRVSLGKSITLEQARQLGLATCIERMLAFTNNLRRLRVDQYEYVAMKVIVLLTSDTSELKEPEKVRASQEKALQALQQYTIARYPEMPAKFGELLLRIPDLQRTCQAGKELLSAKRAEGEGCSFNLLMELLRGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK90</accession>
    <name>A0A232FK90_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET and MYND domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_015980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000082">
        <property type="protein sequence ID" value="OXU31151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK90"/>
    <dbReference type="STRING" id="543379.A0A232FK90"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="226"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71070" checksum="A868547D0E0FDE03" modified="2017-10-25" version="1">MDLAKELIMAVKRSNSHGGYGLQKECEALVGHVLNNMVKSQLPPMDADTKNDEDSAIFREEGNQCFVSGDDEEAIEKYSMSLAYAKSRESKSLALANRSAALYRKQLFRECLIDIDAALDFGYPEEKRKKLKERAEKALEGLTQLYQMKDLNMNDLPASKDSKTAEMTKDEKNLTFIKELIDKEDAATDEMELISKKPANVPRYLADENDLKLANGPSDEAPSISDGIKIAYSEKYGRHLIATKPFEPGEILLLEKPYANVIYREKYYTHCHYCLARSYNLIPCPHCPLSLYCSENCRTLAWSKGHEIECPIQTVLSKLLNLDKDKIRILTKIIRLLLVSTEYGTAIDKLRKDSLIAEKNPDNRTAGFTDDGVFESSSSRSALSLATNLAVRPLMEISAFACISALAIILLAKESKFFGKKYNPKQLKDVVNRNDVKYCASLVFRNCVIVSSNSFSVQQEPGVKAGSGLYLAGSLMNHACSPNTFRHFDGLTMITRALEPIKAGDQIFTCYGGGYQYMSRGERKKKMMDEYFFDCQCQSCVENWPTYQEILRNHVGSIAKTNKDLVEKLKPFRQRLLENKYDIGAVKNVLKILYAEVKMPCEEIVHAIQYLKSYYLGKFHQGLYIPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKE1</accession>
    <name>A0A232FKE1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000093">
        <property type="protein sequence ID" value="OXU31053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKE1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="91" mass="10660" checksum="7759989C59E83BC3" modified="2017-10-25" version="1">MEDPFAAAKHLPDILGLEQFITEKDSRCRAGRPVATRYDAPYVLPKNHSDRVNMNCWGWMTPTEPASLVEIARHTKDFWIVDFFLEYKQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKT1</accession>
    <name>A0A232FKT1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000067">
        <property type="protein sequence ID" value="OXU31344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKT1"/>
    <dbReference type="STRING" id="543379.A0A232FKT1"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000004">
        <property type="entry name" value="RNA-binding motif protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="81"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="6">
        <location>
            <begin position="855"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="676"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU31344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="948" mass="110971" checksum="FF7DFB6E7195CF61" modified="2017-10-25" version="1">MSYPGQTPMGIPGMPPMPYMVGAPPPILGGVMPMPHMVPTPVTAMQTSAPAVRYQRNQPAAPPPRPEAPRIKRERETGPPVTVFVGNIMDRAPDIMVRHILGACGHVLSWKRVQAFGFCEYAGPDAGLRAIRILHDMEIGNKKLVVKVDAKTKVELDKFKAERRKKLKGGSSPLQDETPAESNELEDNDDYMDDMMKAIDTEAHQRIQQIISEHLTDLEIVANNSEEPIKTTVAKILTLDDAEIEESKRDLITREIGKFREVMKKQEEEKAKVKKKREKEENEEREKREKERNKDRKDDDANSTKLEGDDAEPGSPHKGRSDSTGSSRRDKRRSRSRSKERERERERGRGERERETESRHRDRHREGDRDRGGDRDRDRDRAERERNDRAERERERDRERERDKERERERERERERDREREREREMRERERDRDRDREREEARKSEREIMREREEEEEAKERKKNERRAREKDAAYQERLRAWEARERRKQKEYDKENDKKRAKREAREREAKRLKEFLEDYDDDRDDAKYYKGKELARRLEERAVEAEADSRDRCAERQELQRLKEKLYADSKYADPAAEFERLKAEREEQYKPKPVITIIDEDDEKPSSRHKEKEHHQEMPPIETEPIDSDSDEIAHYDNGSSQPAQEISRTPPRPHPHHHHHRRHHRHHQNHHRGEPIEEHEVEQIDLERDGPIKDKRAISSPIRSTTPPQPPQPPIHDEDSRTSLVSEPDKVSGSNFVPFAMGGGGSRGDHAMGNKTPASPNAISSSQNSNQSRKKNRIDVKDVFNNDDDDDSTNNAKKRKLVPIDYGEEKKKKNEEAAAAKNAKEENSKSQEEKRKHIKSLIDKIPTDKNALFGYQLDWAVIDNSLMEKRIRPWINKKIIEYIGEPEPTLVDFICSKVMAGSSPQGILDDVQMVLDDEAEVFVVKMWRLLIYEVEAKKMGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLB6</accession>
    <name>A0A232FLB6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000049">
        <property type="protein sequence ID" value="OXU31546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLB6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12975" checksum="478DBCEE2268588D" modified="2017-10-25" version="1">MVLNMYNKKKKVVGLCPNICFFRFLQSENGIFPVQFPIYRALYLTPSFFLLKGREILARIATGMSIRSEFFARTTRNASRDRGAFYEAFRYGFRRVRSFFSRKYDGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLH6</accession>
    <name>A0A232FLH6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CIDE-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000044">
        <property type="protein sequence ID" value="OXU31606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLH6"/>
    <dbReference type="STRING" id="543379.A0A232FLH6"/>
    <dbReference type="OrthoDB" id="9943677at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039729">
        <property type="entry name" value="DFF40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015311">
        <property type="entry name" value="DFF40_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13067">
        <property type="entry name" value="CASPASE-ACTIVATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13067:SF2">
        <property type="entry name" value="CASPASE-ACTIVATED DNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09230">
        <property type="entry name" value="DFF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="3">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU31606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="463" mass="53560" checksum="C8D1B31710990762" modified="2017-10-25" version="1">MAYGELFCCCKQCLVKDTMSSLIAECYRRLTDTTSSEKPLRGYKVTDVNRTRKIGVACRSLHELKRKACAKLNVTDDLARIGIFLLDGSEIDEDYFATLEPQTTLILRRPGEKLLTEADVLYQMLRKVNESFFKSGERAAGFLTDKLKIKIAVLNRALNNDDKKTLCSRREDHPEWFAGLETNSPTKEAYLHRRCQDRIRGYLYKTIEQVRSSEVYDADPQARRQLERVIVFFKLQLRKDHYFGHYFDRSRSVIKSKPEEGVSSSQSDDETDSAQNCPYEHCPCKLSISSYERYILGLSVDCKNEDDDEVDAKKFVRSAAERKAEEVEDELSDDPKKSKEPLRVEAGEKCPYELVERSKGEMTALCDETGEFRCSGVWKNDKCLYADRHKINPYRSREELVLFSTWNLDHKIERSRTLVPQLLEASKKGDVNEKDVLEFYNNLFTVQNLRLVHIVCHDKGSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED91</accession>
    <name>A0A232ED91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007487">
        <property type="protein sequence ID" value="OXU16308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED91"/>
    <dbReference type="STRING" id="543379.A0A232ED91"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="102"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU16308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="502" mass="56394" checksum="6D3C7A352AC1657B" modified="2017-10-25" version="1" fragment="single">MNSARKVCSNPNPKLYANLLSRLLFSWLYPLFKQGKYHELEAKDLYNVLPEDLSGSLGDRLESCWTRELAESREGKRKPKFRKAIVKYLGWSYMKYGINVFVLNMFVRVTQPLVLGSLVSHFYQNSTSTTWDAYIHTSCLVCLIVLQVMLIQQANYGLSVIGMRLRIACSSLIYRKTMKLSCSSVHQVSSGSILNLLSSDVAKFDTFFTSFHYVWIIPLQAVAMACLIWQRIGIATLVGIGSMIMTTIPIQFLFGRIIRAMRMKGAAVTDKRILVISELISGIRAIKMYVWEQPFERLVTLTRRKEIDIIKIYSYLKGISLATLMFTNLTTLFFTLLVYVLQGNAISANTVYVITYYYYYLRLTLTYHFPNSINVLAETSVSVKRIERFLLLDEVSKTIESSSSSDDTDGSAVSISNVTAKWSIKSVVNTLSDVDIRVTSKKLYAIVGPVGAGKSSLLKLLLGELQPSAGRVSVSGSIAYASQEPWLFTGSIRSNTLAEKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDQ4</accession>
    <name>A0A232EDQ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006005">
        <property type="protein sequence ID" value="OXU16489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDQ4"/>
    <dbReference type="STRING" id="543379.A0A232EDQ4"/>
    <dbReference type="OrthoDB" id="7701485at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30968" checksum="76D0A9535EBCB756" modified="2017-10-25" version="1">MIAAFIETKHTTWDEHIPEFALTYNIAIHESSRSSPAFLNYGRNPTAQKRQEKYYNAKHRDIEHKVGEKVWARNRILSSAAQAIAAKLSLKYADPFIVSARVGMKSYKLQTEQGVDIGKVAVYDLKPCHDEEQFPGDTPESHNSDSTVPEPPISPKERKTNTQLFPNLRHLQKRRRALRHKFRLRLYRSAGADHEETSPNQLYNLSDRTMLPVKKPETIIKMPDELLEQIEKLVAEMILAQTSQISPTLSRRASPRRPTKGRETAQCCSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDU9</accession>
    <name>A0A232EDU9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005976">
        <property type="protein sequence ID" value="OXU16502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDU9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="52" mass="5899" checksum="88831476859E2A24" modified="2017-10-25" version="1">MIASRGESEASASELIFLRSSERVLSARLILRKRLCCPCVCYALDVYFKNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDZ1</accession>
    <name>A0A232EDZ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005756">
        <property type="protein sequence ID" value="OXU16570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EDZ1"/>
    <dbReference type="OrthoDB" id="6095482at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="184"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="304"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="549" mass="61369" checksum="C99DF9C163B23F2F" modified="2017-10-25" version="1">MSEKQQRFYWKGKLVSDKVYKRRCQQSKIAKNIRKTFKGKCAADNLKNCKVVNPIKGRRLIHSKIAKNIRKTFKGKCAADNLKNCKVVNPIEGRRIIHVQTLAEQLICKKCDSILSLMDTSEEKRVGLASIFYVKCRVCSVISSVCTDKQHEAAGQNIHFDTNTKAVIGTFLSGFNIPEFNWKTFKTHEKEVXEAAGQNIHFDTNTKAVIGTLNGGSGNTHLNKFLSGFNIPEFNWKTFKTHEKEVSNILEEMARESCNRAAAEERQLTINNVGTIQRLLPLHLQNTFIFPDLPISSECISISAEQRVRVAGSMDMGWFTRGTGRSYNSFSGSASLIGLFSKKVISYVTLNRKCKMCDMGHDVKDHDCRCNFSGTAKAMESHVAVLLTKNNPILTECNIDVGIIIADNDSSSIAALKNAHDYEIIKQADKNHTSKGVVSALYKLQKSHKELKTSAIQYFQKCFNYCISQNVGDSDSVAKAVRNIPNHAFNNHENCGSWCSYSENSQQYKHKNIGDGFTDPILFEALTKLFDQLAANADKYSAGASSNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDZ9</accession>
    <name>A0A232EDZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005792">
        <property type="protein sequence ID" value="OXU16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDZ9"/>
    <dbReference type="OrthoDB" id="8951118at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="174" mass="19230" checksum="45B0682DE5B77B41" modified="2017-10-25" version="1" fragment="single">MIRFGEVGSGKVWLLVYPRSFYDLMTVALGDSIGRLRVLGRDGVSDYLEGSQHSASVHHAAARGPCLRNVNVAEAVNVGGPRFVTCRCPSNAVGYVPSNPTVMVVVRDRFFRRHVCPTDGCPFTTSLLPHMRAHAQVEYDPDGSSKHHACSLCPKIYKQRCHLMRHHRIAHAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE78</accession>
    <name>A0A232EE78_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005583">
        <property type="protein sequence ID" value="OXU16622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE78"/>
    <dbReference type="STRING" id="543379.A0A232EE78"/>
    <dbReference type="OrthoDB" id="9986793at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="228" mass="27307" checksum="3303190D8DADB3CF" modified="2017-10-25" version="1">MILRVRFYRWAIRMIQQDQDFFRHVLFSDESTFRNTGELNRHNCHHWSDENPHWFRPIDNQHRWSDMVWCGIINGYLIGPYFIEENVNGVNFLRLLRDILPELLENVDLATRLKMWIQLDGAPPHYARIVRDYLNTRYNGRWIEIGGPVAWPPRSPDLTPPDFYLWGYLKNVVYAQRSTRRDNMIELIRTARAAIPRNVLLRTIRQFRARLDLCIQQNGGNFEQLING</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEA6</accession>
    <name>A0A232EEA6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005409">
        <property type="protein sequence ID" value="OXU16689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEA6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="14239" checksum="57D1A738182D5604" modified="2017-10-25" version="1" fragment="single">ILSRARKTYPVSVEHFAAQRVSQLVRVSGVRPHVRYQTIINTSLNFSPSSLFLLLLGPTDDCFDYSRQFQVDRSYTKMSMKSVVLRQLEEKCSLLKSRMEHTSRLIQQHRDPYAELYEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEK3</accession>
    <name>A0A232EEK3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005282">
        <property type="protein sequence ID" value="OXU16796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEK3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14804" checksum="F5CABDDD3350732E" modified="2017-10-25" version="1">MLPTSFACFRLITSAQENLGISSPRGLSNYLVYAPEGEKNTEVFKWPHISQSLRDILPDVFYYKICCVWGRWVLAFSFNNFCSLKLAFLRCATYFIIELAARGVGRFKWFSFRFSARGGSPTSDLPTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGZ3</accession>
    <name>A0A232EGZ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004633">
        <property type="protein sequence ID" value="OXU17630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGZ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="234" mass="26010" checksum="7621E9AF91D7D45F" modified="2017-10-25" version="1">MPQKASEGSEEKVLSTISCTKNLKATKLPQEILWVLCQVSFELDCGLSTISRLLSMPKVEKNSLSTVSLKEGTKRPRKIAKTSPRVRSSRQYNENQNPNNVKFFRPVRPKKTTPKSAKPPSLVTSTTINAVPQKMSRSFLVNSENHLSSSHLDMPLLDKEQTNKTNFISFRIILCHGRKPMAQQRTPAECCAAQSCRCSTFARSSSQTRTATGQRASQITGDTPTYPKSKPPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIY0</accession>
    <name>A0A232EIY0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_013052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004127">
        <property type="protein sequence ID" value="OXU18329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIY0"/>
    <dbReference type="OrthoDB" id="7540137at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU18329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="402" mass="45796" checksum="747EE96D1548FBB0" modified="2017-10-25" version="1">MNGFETSSLNLKTINEVFDNTYFKINKILQELTGIWPYQKRFDASIKQFIVILILSMVSIPHINGIRVWCGKDLGLCAENLAGVTYASGVCTKYFVVTRSKDQMAKVYEKITSNWLTITDPDERVILNKFALLGKYKSIGYVGYITVAAICFSQLGLLPILIDVVLPLQNGTREKLRVVKAEFGVDPYEYYWHIYGAYCAISIVSSGVLMAIDTSYTAVVHQNLAIFNIVKHRLTQAKRAVNTVKDVAYEQIIAAIRLHQDSLEFNNLIEHTYDVSFLILIVICVTFLTFGAITIMVESDNYLDMFRLSLLECGVCIHLFYLSWPGQLVVTESENLYYYTYNNEWYNLSEKSKTLLKFMMLRCMKPCCLTAAGLYVMNFENYGAIIKSTVSYITVVASFRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJK6</accession>
    <name>A0A232EJK6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004015">
        <property type="protein sequence ID" value="OXU18491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJK6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="278" mass="31932" checksum="3D4259C7E3016892" modified="2017-10-25" version="1">MSVEHFAAHRGGQLVRVSGVREHVRYRTIVITSLNFFLSSILLLGPTDDCLDCSRQYQADRSQSKMSVKSAVLKQLEEKCALLTSRMERASRLIQQHRNTYAKLYEDCEEEVHADVHQVHTDEDSMKEGEVKEDNSDAERNETQEADKKEETQQQHQQQQQQAVDADMHQVHAAEDAAMDIVKKDEIDVGEEFLEYFSPASPDTAYDSGEIVNIEPGHEEESVLIAKLTLTVYKVLLIKKKYILEAYKILAQVVRRFTGTLKTRVRSYLTYLRQGMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJU1</accession>
    <name>A0A232EJU1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003934">
        <property type="protein sequence ID" value="OXU18629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7697589at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="79" mass="8882" checksum="42038A4F8F02C9F8" modified="2017-10-25" version="1">MASSSTDWKIIQKVELDSYFGTGAILTEQWEKLFHYCDELFSPCIHKSLLDATHKQPDDSINQVNRIIQLLSGLGGSXT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKL9</accession>
    <name>A0A232EKL9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_001466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003751">
        <property type="protein sequence ID" value="OXU18906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKL9"/>
    <dbReference type="STRING" id="543379.A0A232EKL9"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="80"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="390"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU18906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="420" mass="46880" checksum="AFF65C9BD68E8859" modified="2017-10-25" version="1">MDDPYESAKLASRLREGGGRRRFVGRKIARDGTKQLIECCAQTQADVFATSIGYGSHKCCAKNSTTDCSSYKQKLILKMRIAVVGAGVIGITTAVAVKEAFPSTELTVFSEAFSPETTGDGSAGLWTPYIIANTDEQKILRWSQATHKWLESFWKSEMASDVGVSLVPSYRLTSSSEGLPVPVWSDVVYGCSKLNKKQLERLSKTNEKNYTAGYHYITYTCEPTKMLPFLMKKLRSMNVSIVKTKIKDLKKLKEQGFDVVINCSGIGSRELCFDKSVIPIRGQVTRVKAPWMFETFLEEDDEGNYVIPNMESVVLGGTHQENDFSVYVCPNDLKFILNGCKRLYPSLDNAEVLKKWVGLRPGRDEVRLELENVRTEAGQDLTIVHNYGHGGCGITLSWGCAMDVVEMLRQHLKTKNSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKN9</accession>
    <name>A0A232EKN9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003735">
        <property type="protein sequence ID" value="OXU18926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKN9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="11983" checksum="C0E140FF380556C9" modified="2017-10-25" version="1">MTPCFHFMAVDPDNVLPTSYACLSLIASAQENLGFSSPRSLSNYRVYPFEGEKKKYSVLKWPRIPRGLRVILHDALEHLSADLYSRSDPGSDVGNTTDIILINKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKP9</accession>
    <name>A0A232EKP9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_007954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003731">
        <property type="protein sequence ID" value="OXU18936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKP9"/>
    <dbReference type="STRING" id="543379.A0A232EKP9"/>
    <dbReference type="OrthoDB" id="10038290at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21806">
        <property type="entry name" value="DEFL_defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645:SF0">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00505">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="5" id="KW-0211">Defensin</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280171" description="Invertebrate defensins family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU18936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="10835" checksum="E98EF8200FB9BD47" modified="2017-10-25" version="1">MKLLLVVAFIAVAVTAGLSIPLNEFEDVVDFQDWDEAAVDEDAGVRQRRVTCDLLSFGGVVGDSACAANCLSMGKAGGRCNGGICECRKTTFKDLWDQRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELA8</accession>
    <name>A0A232ELA8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003592">
        <property type="protein sequence ID" value="OXU19135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELA8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="24997" checksum="A8D7E6A79F6D3982" modified="2017-10-25" version="1">MAAKQKVTYWDKRAPGVRRRRSYEAYSFPTARMKADRKPKVKVLRPVREGRRIHASRGSDCSIASMPQEVSKGSEEMVLSTISFTKNLKATKLPQEILWVLYQVSFKLDCGLSTSSRLLKGTRQYKENQNPNNVKFFRPVRPEKTKRKSTKPPSLVTPTIINVVPENMSKINCSSNRHQNMPLLDEESPKTNFISDFYEYFESNLIQKLSYTNVIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELL1</accession>
    <name>A0A232ELL1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003539">
        <property type="protein sequence ID" value="OXU19237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELL1"/>
    <dbReference type="OrthoDB" id="7612378at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="204" mass="23511" checksum="CEBBABD865A7C3AA" modified="2017-10-25" version="1" fragment="single">MSNVPICGLSIPSTEVCSSLLDLSPTRNFIVWVKPHFSDGRNIEDIGCPPLKTPGFRHPLKENCPVQNVCVINKWLREVHQDFIFPLYFFEDNYTSSDSDTTMMKSLNAVTNTPPFLLTKKIKDLEINKKYKIFKYKKVRIKFGANIVLELYASFDVFLPTKMNAFFMENTSEEKLKQKINTRDLQMLRTSSSGRSRVEERGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELW0</accession>
    <name>A0A232ELW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_013044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003486">
        <property type="protein sequence ID" value="OXU19344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELW0"/>
    <dbReference type="STRING" id="543379.A0A232ELW0"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="144"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="693" mass="76689" checksum="88C5FF3D0BF4D537" modified="2017-10-25" version="1">MSSQEESAKIECPICAKEFAASVIEAHASKCLFLNESSSKSQETSKRASFFRGDNVAKKAKGVNFKGSTSPRTSPSTSRSKFLAPTIQENDSDKESSARSKDTKPKDSIPLAEKMRPNSIMSYVGQKHVLGPETMLYQLLSKTEIPNIILWGPPGCGKTSLANVIAKACQHCPGGKYRYVKLSAAMSGISDVRDAITIASNELKFGRRTVMFMDEIHRFNKTQQDTFLPHIESGTIILIGATTENPSFSLNAALLSRCRVIVLEKLTIENLSEILIRAIKAAGGAVHDFEKPPNASINNKFFIDKETVKWLAETSDGDARIALGGLELAIHSKVPSREGSSGSGLNFISLDDVKDSLKKTHMLYDKKGDQHYDMISALHKSVRASDDNAALYWITRMMAGGEDPVYIGRRLVRMATEDIGLKDPKALGVAVHTMQSCKMLGMPECDVLLAQCAIYLARAPKSRLMEDSLRAAQRVVANYKDAQLPVPLHLRNIPTSILGKKDRSALPYMPEEIKNLDFLNGQQHDRTHESGLLACKINALKFSTSTKSEPATKTEVSNKDCNEAPAAAEEKKTVFQKMKQLAKDYWHILIPVHIVTSIGWASVFYIATKNGVDIIGILESLHLSESYLEMLRGSNAGHWAVTYALYKVFTPVRYTVTVGGTTMCIRYLNKWGYLKYKNPKVSIQQFKIEIFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EME9</accession>
    <name>A0A232EME9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003380">
        <property type="protein sequence ID" value="OXU19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EME9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="38" mass="4558" checksum="F6C1CDA85CFEC993" modified="2017-10-25" version="1">MRWRDDRVSALKARGSRFKPGVRHFFVALFTRNTIIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMJ5</accession>
    <name>A0A232EMJ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003353">
        <property type="protein sequence ID" value="OXU19561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMJ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8456" checksum="AE5F31C79122E13E" modified="2017-10-25" version="1">MYRSTRIIRCLISAESASQDDMQALGVNTAAYSISTRNVSEPLAHIDEIEHWSIAPGYADYDMRTRYTKAEETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMU5</accession>
    <name>A0A232EMU5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003283">
        <property type="protein sequence ID" value="OXU19684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="9615" checksum="B003428C81117C8F" modified="2017-10-25" version="1" fragment="single">VFIELEEYLDRRRKKFRRWWSKPLIRQNYLSGYGGYAMVFRYFQLNDEEQFIHFTRMNVQTYNYVYYLIRDRLVX</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN74</accession>
    <name>A0A232EN74_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NR LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003220">
        <property type="protein sequence ID" value="OXU19777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN74"/>
    <dbReference type="STRING" id="543379.A0A232EN74"/>
    <dbReference type="OrthoDB" id="10006908at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="6">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="19330" checksum="BA7B1C9CC08F22B6" modified="2017-10-25" version="1">MSLPFFCEVPKLVHTDIVLQKRSEILLFTTLAYRTIRGQRQVSSFDNDDMNVDFDQEVLNKLHRVQASLNSLTNRNVAIEFLREQLVYMIEKICYITIMFRRLQLRTEEYVCLKIIAILSPLPDVKNIEHIRERYVFGLRSFVENSARQITRNTINDIFTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232END7</accession>
    <name>A0A232END7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003165">
        <property type="protein sequence ID" value="OXU19883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232END7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="46" mass="5443" checksum="9E221FD631E63026" modified="2017-10-25" version="1">MIKIVNKNKLMQNDPKHLDSYSYESLLPQYCDLKNKFSTYTTRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENY0</accession>
    <name>A0A232ENY0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003055">
        <property type="protein sequence ID" value="OXU20041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENY0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="164" mass="18747" checksum="27560C19D0300188" modified="2017-10-25" version="1" fragment="single">KGSFTRDISRSRGAAKEVDKELAYCYNVKKSDQREAQSKDKFTLVKIFIADTSNNKIQLSKDRSIIVTCDHKAILLRFVIKHLQTRCFTHTVSFRLHLDSTGDFSLVIDFRQAAKYAQRILNMLSLRNTYLFLQVPKSTMMHVIGNPSVTCFDQKITALVEPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPN7</accession>
    <name>A0A232EPN7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002915">
        <property type="protein sequence ID" value="OXU20325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPN7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="769" mass="88829" checksum="3C69E107D63AD6EC" modified="2017-10-25" version="1">MSSASLFLYVYKNVHGCREKLEKHVKIQEKSVIVKKVKEVDDDYEPHSQIKSQHISDCPELLFDVIMPQSQIIANWNDKKLTTGWQNILRQAIWDAQQLPSAFSFPNNWITNDTQLKISGACSEAHCKSKIFAEGKRRDEAKKVLITMLPSEYREQHLANLSIDYEPPHLNTTVTHRKLREEAVNEHLGYNPLNIYYWSEAQIEVWNLLHKQQLPLSFDTTGSLVRRFSFYKGMDKSKALFYYVLVVGFKQKIIPLLQALLLSHHVPIIVDVFQRWIESGARIPREITTDGSPTLQNAVCLAFNNMTFKNYNLHCYELLLNKKEIEVPKCFYRLDVNHLIHTARKDWTCFAKADLTIIDFYVRCIGYLTQVESLQQFENVVESIIIVSNSVSMEKESLCCQKKESLLQLFKTYEQVLNKFATDSGQEEFATINENASKEPDHNTIDNSLVLYINSLFEKVINLCPQNTDLTVQPNFYYCSEFTKPFKILCYTFTTWTNVMKRIFMSPNNVGTSCRSETYNKDRKQAVPRPIIIPKFLLKERTKIAATTKFVFTRTKSIKKNEKISAHDNMLDLDLEKLVISNGTKTETLFPDQVDHELPAPTDVQDVQFNSTVVYGDIQTNELFDDLNLSQIPTANSDQHFHSTLIYNGIETKECYQDLKKLQTPAVHDLKHQVTDTCSSTKSNEETSKSILEPSDISIQKHDLKDLFKKLLNAINERKLILNETFPNENSEDNKEIKTKWKLYDSLATTSQEILSPAENIALILFVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPV3</accession>
    <name>A0A232EPV3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002887">
        <property type="protein sequence ID" value="OXU20383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPV3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="185" mass="20415" checksum="61ABA9E8545E39F5" modified="2017-10-25" version="1">MSSIPSRTMTATRLDPSYPCHGIAGSSIYVDGRCVICRQPSTSPAAMDVKRMATGVQVGVKIFIPLILPTNTLLPSYRRIISYRVISAEDESSPGGWIPCHREDWDAPEQSCLICGQSLGDPVSCLRLSGTESLLKKDCINFVFLPDPLEKFHSGTLIIGSLVKKYHLSWPIRVLSAIMIRQRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ15</accession>
    <name>A0A232EQ15_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_006974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002859">
        <property type="protein sequence ID" value="OXU20431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ15"/>
    <dbReference type="STRING" id="543379.A0A232EQ15"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07211">
        <property type="entry name" value="Pat_PNPLA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045217">
        <property type="entry name" value="PNPLA8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="297"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="301"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="333"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="487"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU20431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="641" mass="72546" checksum="E681003362A52ABF" modified="2017-10-25" version="1">MSLSKHVRHCRRCVALTRPLTESAAGRDAGESSTALASKLTSTVPLNFVNKAKMTMHSRLKMLGQLKDFFNKSSYDKNLQLMLNKEWLDFFQKLTYAQIDTIRKYSLLDDSKTQQEQDEKKIAQEKEKAVQKSVATTLPIIEEKVTAQPQAKQAPVEPQAAMETKESYYYLPQVLAAMLPRLSNKSKEISVPAIPKWKTNLQTSVTKNSIVSRTRHILNSIATAESNASKWRRIDDLLQHIEQFPEARHNAVKDGGIRILLRTRELTKDEQIRGTIREALAVLGHVDPLPARGIRILAIDGGGIRGVLVIEMLKKLEQLTGKKVYEMFDYICGVSTGAILSAVLAIKGEDEQGGHKRKSLDEISVLYKELSTKIFTQSPLRGTSNLVWSHAYYDTALWEQMLQEHLGDRDLIKTTRDPIAPKFSVISAVVNHERVMAYVFRNYAIPIGVESQYMGSHKHKLWEAVRASAAAPSYFEEFKCGEYLHQDGGIMVNNPCAVAIHEAKQLWPNSPIQCVVSFGTGRTPFNINTCAEDKKEASASSWKEKFYKILDSATDTEAVHTMLNDLLPDHVYYRFNPYLTEMLTMTEIRPEKISQLEQDAAMYIRRNEEKFQKAAKVIMQQKTPSQSVVDWAKLQKNILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQF9</accession>
    <name>A0A232EQF9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002805">
        <property type="protein sequence ID" value="OXU20536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQF9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="16354" checksum="F799EE8039520E1B" modified="2017-10-25" version="1">MRAQLTCTCGSSKSQWVERSVAGEKRDENTGGVRSAAAAVAGLLSRGKLSICHRAWREATPCLPQPSPRTIGRKVLGERDDGAGAREKARKQKAPGVYSWLTRISKALVEIVTIPVSKWPISSGPFPSDSVEIKSRIRRKIFVVSTLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQG2</accession>
    <name>A0A232EQG2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002790">
        <property type="protein sequence ID" value="OXU20557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQG2"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646941" description="Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU20557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="95287" checksum="3E4FCB68A2224530" modified="2017-10-25" version="1">MRLLLGLIFLCPVPSVLSECLESLRYFINSNLSVNQITIVSDNSYDYDSSLIDHASKMFRNRFPTMGIDKRVPTNHPFNLPRSTIIGLPSTFFVFISSSDFYIRNMLDHLYKLSWSIRRSKILLIHYNSNASELLEYAWKKQFPDVTLLHVRFKVALKKINASSSFHASMIVQFNGFLNIYSKFDCSSNTIWFPDKMKNLNGSPLRVDLVSDPPFSNIERNLTGHVVKKSGTDVWVLDFISQGMNSTLDFAPRIEKTRTNLFDDIDLTDLIRELEGGHIDLIGNSRTSKRLSDVIKTYEFSAHVVATEFCPIVPIIVTKKNSLDSHFLISFLTIVIGVLFGVLLARFCHFDRRLWSFTEMVRLILGFNVREQPEKCAERIVFLCLVILSMRYSALVFNELTKIHMNVEQQVPFDTLSDIFKVGLTPMADTTVMPENTNLNITDDDGIEHLVPIQFWGSRKLCLERLLNNKNVTCLVANLVAEPIVMMSTIQEGKAVMGVMKDCPSVSKSRLMIAKGSAHRKEINRNIVRLKQSGIIQKCLDYDYFNLKLQVGFIFGAGKDEKLKDHLLIQLNMKFLLTFFLMQSTLSECLKSLKDFINFNLSVYQITIVSDILHDYDSSLVDLASKMFSSRFPTIFVDRSAPTKHPFNMPASVEIGQSNTLFVIISSSELYTRSVLDHLYEIAWPVRSHKILLIHYNSNTSGLLDYAWKKQYKSVTLLQIRFDVAMKKINSSSSFHTPTIDVFDGFLNIYLKSHCNSKTIWFPVKTNNLNGRSLRVDLVNDPPFCNLERNLTGHVVKKSGANVMILDFISYGWILYRDSRSVGLIPSMKLTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQH8</accession>
    <name>A0A232EQH8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_014440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002764">
        <property type="protein sequence ID" value="OXU20613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQH8"/>
    <dbReference type="STRING" id="543379.A0A232EQH8"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU20613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="13974" checksum="1AA34EB1D384361A" modified="2017-10-25" version="1">MVNDEVSEANKKPLAIFKNPMFQQKFRPITSSGKKRIWRSLKQVLAQERALPWPSDAIHYSSINAPPSFKPAKKYSDISGLPAHYTDPQTKLYYATTDEFMTVRSLPMDITAGYLALRGAPSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERK6</accession>
    <name>A0A232ERK6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_015498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002582">
        <property type="protein sequence ID" value="OXU20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERK6"/>
    <dbReference type="STRING" id="543379.A0A232ERK6"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF144">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="372" mass="42477" checksum="13567DD44C15F27F" modified="2017-10-25" version="1">MDNISEFDIKLEKDIYYAGETIRGHVILHTTENFKLRSMRLSLRGQAHAEWKILVSGDRRNVKDDQYFVDERIVVWGHDSSEGPIPILPRGKHQFPFTFNLPESALPCSFESRTGYIRYYVKATVDRPYASPPQGLKYFTLIGPHIDCMDEQYLKPMIGSEVRTSCCFCCRRNPVELSAQLERSAYVCGESIKLRAAIDNKGIEKAWLQVKLTQYVEFFIDRGVLGTSKEQQKVVMEYKGEPVPPGTAIKWDSSKKMILPVCPPTLVGVCRLIQIYYVLKVSVQLEKSGEDMQMHFPITVATVPFRIPNLTQQPQIKYETAMENVEGGCYIGPEFLLGQVYDGSDHLTTQAPLILYRPVYVCIANEKKTQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERQ1</accession>
    <name>A0A232ERQ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002564">
        <property type="protein sequence ID" value="OXU21038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERQ1"/>
    <dbReference type="OrthoDB" id="6740702at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="198" mass="21279" checksum="EF57CE2358406EC6" modified="2017-10-25" version="1">MAGKSDLIGVTINSQNFACGSAGISLRSVANFFVDDLWMLVSGVTQSNENFEIDDNFSIEATYAEVPHGAGRKKSFGINMLGQRSLISIIRNSDNLCYPRALVVGEAFVNLKEDATNTTKKAWTIIRDSRRTLQKERALGLTAAAGVTIPLDGSYYRGGRSSADHTACSKLESSGRVVSVYLAHACPGKQLITGHAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES09</accession>
    <name>A0A232ES09_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002533">
        <property type="protein sequence ID" value="OXU21122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES09"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10749" checksum="FFD84A997CE03217" modified="2017-10-25" version="1">MTMDVEAQPLEKLLVLQNLFELSNNNQNVSSTNYQTTGRQVWIKIIWGVRVWMMLADSSGRLGFVVGCHRYAKLEVGRTSDTDDLWFEYTANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESC2</accession>
    <name>A0A232ESC2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002453">
        <property type="protein sequence ID" value="OXU21242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESC2"/>
    <dbReference type="STRING" id="543379.A0A232ESC2"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF1">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37729" checksum="1D0404B871465C9D" modified="2017-10-25" version="1">MALMRMTLSAFARSRFGVQALPRFSASKPRDNMVFGFVACNFLSTHRLTKNIELLTEDNHLPIIKDSPKKVINPSENGENRPLLVLLCWLLSKRNHIMKFVNFYMEQGFDVVTVSMTPWQLMWPVKGSRIIAHDLLQFLDQNKHYEQILLHGFSVGGYMWGEVLDFVHKDRQKYDHVINRVVGHVWDSAADISELTIGTPRAVFPNNEVLQNVMKKYLEYHMKAFHKQATQYWIRSSQLFHLNLVHSPALFLVSTTDPVGSLASNMRVRDSWESLGVKTYTKIFEDTPHVGHYRAHPKEYVAELYTFLDRLQLIRNEEKIRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET09</accession>
    <name>A0A232ET09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">chymotrypsin</fullName>
            <ecNumber evidence="7">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01002348">
        <property type="protein sequence ID" value="OXU21493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET09"/>
    <dbReference type="STRING" id="543379.A0A232ET09"/>
    <dbReference type="OrthoDB" id="10061449at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556712" description="chymotrypsin" evidence="8">
        <location>
            <begin position="18"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="288" mass="31062" checksum="99964FCD27FF60CF" modified="2017-10-25" version="1">MTSKLIVLACLLAVAHSRVIDVLRRNAHISARVVGGHDAKPGEFPHQVSLQFGIPEIMPSTHFCGGSILNERWILTAVHCLEAIDEIGYLGHFVVKAGKQNISRVEETEQVSFVEKYFKHENYTGTEEEPGTSDIGLIKLKTPLKLNERVAKIALPKKDSEPTGQAILSGWGAISDNGENQDLPQILQTVDLPIISRKECRQAIATIIPGTENLVDETNVCTGPLTGGHSACSGDSGGPLIVKNKNGVAELIGIVSWGVSPCTAPGAPSVYVRVSHFIDWITQKMTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET95</accession>
    <name>A0A232ET95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002304">
        <property type="protein sequence ID" value="OXU21579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET95"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="180" mass="20766" checksum="9F03177DE8351D18" modified="2017-10-25" version="1">MHCIHHESCDSLEQSPQNKASSEDVPPVDSGYEADSSATSSDKLEEDLPSGSCKEIVVVEPEMKWRMQAHKVFIDCDCKLDPHNREYHSLRTLPYGYAEARLQPLEGQLVRSKPRSSVEKKLQKVIVEVKANAEKKLPKRIACTSPRFVPLGTAQQRRQRTFPKEYTSSNYHRRWNQKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETK9</accession>
    <name>A0A232ETK9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">39S ribosomal protein L41, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002261">
        <property type="protein sequence ID" value="OXU21699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETK9"/>
    <dbReference type="STRING" id="543379.A0A232ETK9"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU21699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19969" checksum="25068B6E625B1C5F" modified="2017-10-25" version="1">MSVANLIITRGISTSCARYGKRNFKKFTLINKRGTRIFKKMQAEDPDPRYPIDKRGVRDVGYMDGKKFVEIPEMIPELIVPNLEGFKLKPYVTYKVTEVKNEKFTAEDLFYAVYSKKIREDYNKGKLGPNGEPLEPSPEELLTPKEARELASKPGNDIFTARPKPAGTIMPQIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETN3</accession>
    <name>A0A232ETN3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002256">
        <property type="protein sequence ID" value="OXU21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETN3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="201" mass="21370" checksum="68B3FB79590FE824" modified="2017-10-25" version="1" fragment="single">ILKVTEMSKTPVRGWLEPKKQTEPHSAKSKPIARVRPVNIVPSTNVVTGPQAYSNPTVFLASTSKPAAPPKAQRPSNNDQPKSSQAHKTSKAAGGSSKSSGNVVKIVNINVINVNNASDKLTKLKLSNESSSSVSCSSRNDVKQKPKTTRAHQPQSSQSAPRNTPKTAGKTAGVKKNESSGRRQGVVVTQKQSSVCRIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU86</accession>
    <name>A0A232EU86_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_008140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002156">
        <property type="protein sequence ID" value="OXU21918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU86"/>
    <dbReference type="STRING" id="543379.A0A232EU86"/>
    <dbReference type="OrthoDB" id="9976881at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09401">
        <property type="entry name" value="LIM_TLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01784">
        <property type="entry name" value="RA_RASSF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21886">
        <property type="entry name" value="SARAH_RASSF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000104">
        <property type="entry name" value="Ras association domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000278">
        <property type="entry name" value="serine-rich adhesin for platelets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF15">
        <property type="entry name" value="LD40758P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="7">
        <location>
            <begin position="420"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="8">
        <location>
            <begin position="520"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="65228" checksum="2A1701BBDEAC55EE" modified="2017-10-25" version="1">MWKCHKCGKPVYFAERKQSLGYDWHPECLRCEECGKRLNPGQHAEHKGVPYCHVPCYGALFGPQLFGHGTRVESHTSFGKKESRSSLPRSHLETKLKLFNQYYEGKSGGIRSREVNGRLILEGALRIYWGVRGVIHLKEDDDQRTVVTARHRNSCRRSYVEKVDNEEIKNEESKDSSPSNSQLEIESNSVPASPDHIKSLTLPMKLDVKKVEWDELDDLLQVERKVEDGDKLYQTMPKSLPSNSSHSKAATPSTTATQSSADVSEPNSPSTDTSNSKVKDNSVNSTPTHSISSSSNTDTPNYQGTPNKNGALRRVEYFDSLDKNAASTQSISDEDSWIEKGLNRSMSGPDCLQRHRTDSDTDSVSSLHFRDDDNMTMSTDSGLELDGVVLRRKQGSTAIRRRPGARRQSRNRLRRRCSINGHFYNRETSFFTPPHGSQMSVWVTSLVSTQEVINLMLDKYKVDAKPDNFALFVVRDNGEQRRLREDEYPLEVRVVLGPHENIARLFLVDKLSTPEISSDVAQFLNLSLAECQNILQRYHYEEERQILMLKEKYKEMRRRIKQRMEDLKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUJ1</accession>
    <name>A0A232EUJ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01002135">
        <property type="protein sequence ID" value="OXU21976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUJ1"/>
    <dbReference type="STRING" id="543379.A0A232EUJ1"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="93"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU21976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="276" mass="31284" checksum="8F5400319C1E3B99" modified="2017-10-25" version="1">MLEMSCSSIGVALFFLAVMICAISEVARYHTKHFVFVVISAIWATWPIPLMFFRVRDWRNALIPAWGARQAAKVIGINYQVRGKENIVKDSGAVVLINHQSNLDLCVLAELWPILQRCTVISKKQVLYFGTFGLASWLWGTIFIDRVKKEEAQSTVNSTAEIIKRRKAKVLMYPEGKRHTGSSLLPFKKGGFHVAIDSQTPIQPVVVSRYYFINDKLKKFDSGTSYITILPPIPTKGLTKADLPQLIEQTYQVMNKVYQESTQEALESHMESLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV95</accession>
    <name>A0A232EV95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_016106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM214 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002039">
        <property type="protein sequence ID" value="OXU22257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EV95"/>
    <dbReference type="OrthoDB" id="10022292at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU22257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="282" mass="31662" checksum="A5098128269466CC" modified="2017-10-25" version="1">MYSGGWEVVTKNKKDKTAASAKNGKLSKAEKKKFIENAPKVEDFLPLDQVKTLYDNLDGNKENKKPVKEKENKTKENEEKKKQQKQQQAEKKKDEPPKEKLPKSIEEALNSINVAEVQNLLATNQAHFPDAPLVWLKTLVAFLNSKIPVEKDDPIFSNKSDGYPLNVVPKSLRVVLEKAIDSAGATNARLFYEFILTAMAMEMSKAVPVVGYKIFVQLMAKHDPKLSSSSIAKLTSMRNSYQNRKPVGLSLLWSFNQGGRENLAVGLKVWHEVLAPMLEAKX</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVD7</accession>
    <name>A0A232EVD7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002011">
        <property type="protein sequence ID" value="OXU22313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVD7"/>
    <dbReference type="SMR" id="A0A232EVD7"/>
    <dbReference type="OrthoDB" id="6683043at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6711" checksum="ACFD97EEDEC6A159" modified="2017-10-25" version="1">MSLHVFWPASAVLTLFVVGVIMILLKFGPRICKTRHEPLPTEQDWMGKSYEHELSVSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVR8</accession>
    <name>A0A232EVR8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001964">
        <property type="protein sequence ID" value="OXU22432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVR8"/>
    <dbReference type="STRING" id="543379.A0A232EVR8"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47678:SF4">
        <property type="entry name" value="SHOCK PROTEIN 70 (HSP70)-INTERACTING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47678">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="246"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU22432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="319" mass="36376" checksum="C8E80CA024539FE0" modified="2017-10-25" version="1">MAALTLMNVGQQRSTIEDDDQSKKLGEKGVELILENNVFEALKCFTKALAHNPKDSRHFLNRCYCYLRLSENKLALSDAERVLEKSRTDLYLFLARLRAGQALFGLKKYHQAETYLKQALAVHPNNVYAKRELLRVQIKRIVYNGYNERDAILALKMHPTTLEAISYLSTNNTRPLGSNGPQVDDDLNVAYHDLSDVYYSSDEDDDPSDFEFLNDMSNYQPGKIHFAHLLPIISSDVKYKTLVNIYSIWVGKLNSTITEDVLQAAFNQLGNVTKVYKPPNADYAFVNFDNCEDVKNILKISSYLIDGKKVPVQPAYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVU9</accession>
    <name>A0A232EVU9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001954">
        <property type="protein sequence ID" value="OXU22467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVU9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059418" description="Invertebrate defensins family profile domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9537" checksum="7E61D8268C6D06F2" modified="2017-10-25" version="1">MKSRIILVVLIVFAVVQTGYASWCGGELESQCYQRCGGPPYTCSKGFFSNEQSCVCGNKGNSDDSDPMDVTKTDFYKLHEPSPDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWH2</accession>
    <name>A0A232EWH2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001868">
        <property type="protein sequence ID" value="OXU22681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWH2"/>
    <dbReference type="STRING" id="543379.A0A232EWH2"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF114">
        <property type="entry name" value="IP04436P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="60343" checksum="4A22A89DD15BED1F" modified="2017-10-25" version="1">MSREREAEINNNGQEPLRSIVTVMDLRSIFLFLFLGLSVSDGYRILAIFPFDGKSHFGVLNSVVKDLASGGHQVDVMSNFPPKESFPNLTHIVTLPVAGAQSRIDYNLIFYPEKEANWLHDKKRRMCDFLGLPKVAELIRNPPTNPPYDLLLVHVLTGYQCLAAIGYKWNIPVVGVVTTTLYAQMHHIIGNPLNLALTTSHFGFYKKKLDFWDRVHNVVQTYRVISKFYGYAKDQDYYIKKHLGNDMPSYRQLEKNMALMFTNSHYTYHGVTPKTPGLIEIGGINIKNDTSELPADLKKFLDKSKDGFIYFSFGSLVVIETLPHEALERFYSAIRKISPVKVLMRVPHPDDMPKNMPDNVYKFSWLPQQTVFQHPEIKGFVTHGGAVSTQEAVYYGVPMICVPFFAEQFINCDILSHKNSSLTLDIYRNQRLTQDDYDHAFREIITNPTYKESVRKFSRVYRDRPLSPKETLLYWTEYVIRHGKNILKSPAVNLEWYQSDLLDVHAFLFTLMTKTSKKSSKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWN3</accession>
    <name>A0A232EWN3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001836">
        <property type="protein sequence ID" value="OXU22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWN3"/>
    <dbReference type="OrthoDB" id="8192785at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37685">
        <property type="entry name" value="GEO11136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37685:SF1">
        <property type="entry name" value="GEO11136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012036917" evidence="1">
        <location>
            <begin position="26"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="357" mass="39276" checksum="A8BB2B521E1828D7" modified="2017-10-25" version="1" fragment="single">ISKKMASQRLLLFVLLAASVAVALSAKSAKDVIIGARQPGDHLARREFVKKDSSWLQVVKLQQTFGVDYGKITHVKLLDQNLKGNGATASVLAGGPGNSYITVQFKSQSLAAVLAEKLPNSLIVGDREPGDHLMQREFVMKGYKWLRSVKLTKTFTGSVHSKITQVQLLDQNEKGNGATAAILSGGPGDNFVTVQFKSLRGHGVNYVVKLYGKFQEMASQHLLHLALFAACLAVTLAAPKHVIIGIREPGDDILQREFAVKKSQWLQVVKLTKTFVAQSNAKITQVRLLDQNKKGNGATATVISGGPGSTYITVRFKSVRSHIQKHQRAQHRLHCENLREITWNFVVKNTYHILLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWS6</accession>
    <name>A0A232EWS6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_005749</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001825">
        <property type="protein sequence ID" value="OXU22796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EWS6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22708">
        <property type="entry name" value="FHA_KIF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000005">
        <property type="entry name" value="Kinesin family member 16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000021">
        <property type="entry name" value="kinesin-like protein KIF16B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF6">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="13"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="1227"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="723"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="928"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="603"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="769"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="939"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1141"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU22796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1364" mass="154012" checksum="D768DFED411ABDCD" modified="2017-10-25" version="1">MRADEITAAAMASVKVAVRVRPFNKRELAMNAKLVVQMDSKRTRIFNTKTPGSARDIDREKYKDFTFDHSYWSFDDTDENYASQEEVFYDLGTEVIESAFEGYNACVFAYGQTGSGKTFTMMGSPESQGLIPRICKTLFARMAAGKESGASYRTEVSFLEIHNERVRDLLRPDQTMSHSLRVREHPKRGPYVQDLSNHLVYDYSDIQECMVRGNTHRTTASTNMNDVSSRSHAIFTITFVQAGFNENNMPSETVSKVHLVDLAGSERANATGATGQRLKEGAHINKSLVTLGSVISALAELSSTDSNCSRRSIFIPYRDSVLTWLLKDSLGGNSKTIMIAAISPADCNYGETLSTLRYANRAKNIINKPTINEDPNVKLIRELREEIQKLKSLIGKDVSTERPLLAQIYEKQEQEKVLTEEWAEKWRETQKILSEQRALGLRKSGVGVVLDSEMPHLVGIDDDLLSTGVTLYHLKEGRTLVGTEDAATTQDIVLTGVDVEPEHCVVELEGGTATLHPLSPHCWINTAQVDKPTRLSQGCIILLGRNNMFRYNDPVEAAKLRKEGGLGNGNLQSTVVNLSRLSLLSWSVSDLHVSSSSDNLLNSSEDLRAIEELEQQKAALIKEKEDFKREQEEREERWAARREALEEAQRELEREWGAQWREWAEGIAALERRQRELRQRRQLLEQERRDEMTQVESLCREVASLRTTLQSKHRQFQEFMNVQNRRERQRRISEQTDEGAGSDGSLPESWSSFNEDKSVDAMKKFVSNNKELAALELELQNKMRTLNERQSKIDKMDEELTDLTERQKEISSLEQEGITDKKILLAARSQEQLEEILRRKRSLSLNLKRALPASPGGRSSSSGDASSDDMLSSTDQLRFSQNGSSLQEDDENHNRKRKIAAALNLVYPELIASSIDTVETFHTAAADSPEVQFPELEAETATTAASSSTTEKTAEKPKTQEEQNEDSKSDNDLDFKTSIDEIRVFQRAVGETNHNGADGNFNSSAELSEKQACNGTAETNGVTQLESSVDESLLESSQTMKRLNQKITRQRALVMKCLEASPPSKDELNRQIAALQDLQRQQIELEVSLLEQERKSNGQLAEEPPTIVPPPVVNDDSDKVSRISEQTCNGDGEMRRPPGLEQSSSICNSTMSLSNSVTRSHLRSRQSNDEDDKSRRIAARVPQSRGYSSVYLTSQNRGERLTSPYALTITRSLPSLIANDSDGDSVINMIISVPSYVIRGAGTSSHYEYEVRVIAADDSWTLLRRYRRFRELYVSMRQKYGSKVSGIRFPPRQVFARYEMIARQRRKRLEEYLRRLIQVCSELPNCEPLYKFKGNLSNIDKQSLLEFSSFFRRGTFESSKYGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXQ2</accession>
    <name>A0A232EXQ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_001995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001719">
        <property type="protein sequence ID" value="OXU23135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXQ2"/>
    <dbReference type="OrthoDB" id="9988013at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF6">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37834" checksum="00D3801399A20068" modified="2017-10-25" version="1">MSLFRHDRYTEQVYCLLTGSLDPTCADYPPSYLWAVKSEEGEKRSFRLNNGVVRCVIAFLAAVLLKNAICADSRLRVKKYCRERDKAMTVSDEIEEYSNETDDYLLVVDAEINSTIVLENILQYELASGDESKVQPPRLWYWQDLNQTLEMTEVELGMDNNVTQIRVHMTAEYSLIIRTLLEEDIGIYRCIGDKDRENNRSLFNYRLEPVLDEESTNSTQQGNETEYKKYRELNLLPVTQLFAHKKALEMKIERSFKNSTDEELLAIRDEGVTLELVSEWGPWGPCEECVKKRGVRTRRAFCRIKSHINEVKPVPSESIISIKYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY02</accession>
    <name>A0A232EY02_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001715">
        <property type="protein sequence ID" value="OXU23150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY02"/>
    <dbReference type="STRING" id="543379.A0A232EY02"/>
    <dbReference type="OrthoDB" id="546383at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026507">
        <property type="entry name" value="PIRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF161">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14892">
        <property type="entry name" value="PIRC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47957" checksum="3ED33868E436CF7A" modified="2017-10-25" version="1">MTENYQPWECANEARAVQQAECECSEPPGPRTDEVYRTFNIPERFMYPSELLLLELHSLVPHSRAEAIDCRVYNNLYLCLSGARLLNVAFDDAIAVQTIDDVELHLEDLRLDWISEVAFVDVANSSALYLRDNRLTNLARHFFRSLDQLTYLDLKDNCISHIEDGAFARLSSLETLLLDGNKLLTFEPGVWRGLAGLHELYATNNSIALKRGIFRGLRHLETLALDANNISDIPAGAFEGPRHLDLLYLSRNRISTFVPEVFQGLAELSELDLGSNRISHLPSEAFRFLASLEKLWLSGNQLAALRAPDFKGLSGLKKLYLNSNSLESVDMAAFHVFANVSVDPGLNINGALLRSFKGASELLRGYRQNEGSNPHPCYRSTSMDYGWFSPTVHTVPTTYYPRNGAFSLEVARGGMYRNCSLNTELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYL4</accession>
    <name>A0A232EYL4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001622">
        <property type="protein sequence ID" value="OXU23399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYL4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="157" mass="17931" checksum="6ABAEAAE7C08AA6E" modified="2017-10-25" version="1">MRNTPSSTGTLLRGGVLVTKCHIVTASHCFVGEKLSSLRVLVVISNFNNEAEVIDVEKEKLDGDDHDITVLKLKKEVIFHLARTIPVYDQFYDKDDVQLEIIGWDKTERGSPVLYSYNGVQKLIDVNEAQCKKSCSRINTQARVYNYRDFIKDMIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYP2</accession>
    <name>A0A232EYP2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001620">
        <property type="protein sequence ID" value="OXU23410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYP2"/>
    <dbReference type="OrthoDB" id="7694704at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="2">
        <location>
            <begin position="89"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="178" mass="19955" checksum="019D4828B238A8BB" modified="2017-10-25" version="1">MQLTINNLRGRLLFVRLLMRTRGERINSGRLHLHKNGDLLQKLGSRSSHVGQLCLGISSESDELQWIRMKVFLGLLVAFSVASFAFAAECKTSLTVIQPKEDVAVDNQRYVMINIPGFEQNATSLECLSGQACAKGSCQQDYKLHQFLTVPHGKSQFSLDELQFRFFRLPYGCKCGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYV6</accession>
    <name>A0A232EYV6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001577">
        <property type="protein sequence ID" value="OXU23541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYV6"/>
    <dbReference type="STRING" id="543379.A0A232EYV6"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="414" mass="47229" checksum="9E92E6A4E111C60F" modified="2017-10-25" version="1">MALKQLTEDNIFFIKCLFYYFKVLGIAPISLYTRSTKKNASQCVVFTRSNRALVYDVVLILILVTANIYKILYLCLRVSSTKIITIEAVTNCLEDFVACLSAVFILIIICFSWEKLCAVVNAISGLTECLDGFGVENPKKYKLQLEICMIIFVNITTWILVFVITAVAEFSYLLYDTIMYSNVIVVNVLLIQYSVVLKLLRHNFKMLNKNLLVICQEVPIKIQSSVESNGSVERLSQLRKLHASICKVSRDVSNYYSYPTLACVVCVFYTLIYTCYYIARPIVLYHQNLRGDMFVMSLFYGLLLVLSVVILTKSVTATIDESGRTKEIINAGLLRFEDDEKMSKKVMGLVKNILENYWIDGTFCFQLNQFSSYLLHTDVKFKVSELFSLDDSLLTSMAGSIATYLVIVFQFLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ33</accession>
    <name>A0A232EZ33_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Nicotinic acetylcholine receptor alpha 3 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_001415</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001555">
        <property type="protein sequence ID" value="OXU23615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ33"/>
    <dbReference type="STRING" id="543379.A0A232EZ33"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000012">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="15"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="236"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU23615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42833" checksum="0C26F4E4126BE129" modified="2017-10-25" version="1">MLPTTGGCSGNPDAKRLYDDLLSNYNKLVRPVVNVTDALTVKIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWDPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWKPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDEVQGSNVVDIGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTLSICVTVAVLNVHFRSPQTHVMKPWVRRVFIHVLPRLLVMRRLSSFCPWLYPRMNPSLHIEQENKLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZM3</accession>
    <name>A0A232EZM3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_006505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Myofibril</location>
            <location evidence="11">Sarcomere</location>
            <location evidence="11">M line</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001516">
        <property type="protein sequence ID" value="OXU23720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZM3"/>
    <dbReference type="STRING" id="543379.A0A232EZM3"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09336">
        <property type="entry name" value="LIM1_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09337">
        <property type="entry name" value="LIM2_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09338">
        <property type="entry name" value="LIM3_Paxillin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09411">
        <property type="entry name" value="LIM4_Paxillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000008">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000012">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000018">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001904">
        <property type="entry name" value="Paxillin_Lim_dom4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047075">
        <property type="entry name" value="Paxillin_TGFB1I1_LIM_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="332"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="392"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="450"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="533"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU23720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="590" mass="65442" checksum="9C3EBD855DB84129" modified="2017-10-25" version="1">MDRTMYGKLEPGYSYQPYRVTVQKNGLAPGCKLHFIFDSCCLKESSFIVQPTYQNREAIEEARTGGIGGGGVSQYNQAGTGGKMPSLNNNLSELDTLLQDLSNARYNSHATDRESTSPMLRSTSSLSTGRPTVDTLLEELSTGMPNGDYPEGQRVKVTVQETTTEVQPGSAELYYPPSHHGSLNRRDIERSYAITGNGQTASNATKELDDLMASLSEFKINGSNHQRQTVTDSAYAKPNKATVVKQYQSISSSGGGGGSPLPPGGVIGGGGVQEQRVHISETRTSHHYQPQYESHTATAQSVTHIKQNQLDSMLGNLQADMSRQGVNTTQKGCCSACEKPIVGQVITALGKTWHPEHFTCTHCSQELGTRNFFEREGHPYCEPDYHNLFSPRCAYCNGPILDKCVTALEKTWHTEHFFCAQCGNPFGEEGFHERDGKPYCRQDYFDMFAPKCGGCNRAIMENYISALNSQWHPDCFVCRDCKKPVSGKSFYAMEGKPLCPKCDCRQKFQGGSFFDHEGQPYCETHYHAKRGSLCAGCHKPITGRCITAMFRKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCHGCFEKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F075</accession>
    <name>A0A232F075_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001436">
        <property type="protein sequence ID" value="OXU23979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F075"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13837" checksum="97DF2D6D43C9F8D2" modified="2017-10-25" version="1">MKLFDFTFFLCVLCVYIVPAFFFSMTECSVVRKVDPAEKYDDVSKTQSEQNDMTTTSTKHIQCSIKEFEVNFIYRGNVVENYYNVLCMFSQIDLHPNTSFVTQLDSRPFAPHMASFCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1F8</accession>
    <name>A0A232F1F8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Luciferin 4-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001310">
        <property type="protein sequence ID" value="OXU24403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1F8"/>
    <dbReference type="STRING" id="543379.A0A232F1F8"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000025">
        <property type="entry name" value="luciferin 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="45"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="452"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60535" checksum="162D785C2E9527A3" modified="2017-10-25" version="1">MTDNGKANNKKAPFTIENNVIIGASVPMDASSYDIGAMILKIFSDHPKHVAQIEVKTGKETLYQDMKDATIRCALWLQKQNVGSGDVIAVCTENQPDSYIPCIATLYVGAVFNPWHHEVTLKTAQYLMSLTRPKVMFSCESALKVLMEAARLEKVDTRFIVFGKYPEMQSLRDTMRLQTNEEVRTFQTRSIRADNIAMILFSSGTTGMPKGVTHSYESLYRNISSFTILGAKNSICLWYSSLYWISGTLCMLRSILTTATSILHENFDPEETCKVIEKYKVDWFFISPSAINLLYKSNVLQKYRLKSLEALLTGGSKLSREVIEGLRKSLPHAGVAQGYGMTEIGGLATVQMINCKKSDSVGFVIPNIQLKAIDVATGKVLGPNEEGEICMKSPTLMLGYYKNPAATRATIDDQGWLHSGDKGYYTEDGEVVIVDRLKEMMKYRGHQISPHEIEEALMRHSAVMEAAVVPVPHDVDGEWPMAFVRKVPGAKVTEAELVQLSQSELGEVKKLRGGVKFVDAIPYTASGKISRKELKEMAKLVHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2M3</accession>
    <name>A0A232F2M3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001119">
        <property type="protein sequence ID" value="OXU25076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2M3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="157" mass="18216" checksum="9131C573F23993F4" modified="2017-10-25" version="1">MVDSTVIVHTFLWTFMIAAISTDFFNGRFDLCGPYPRRPLQDKNQAYAIGWQLHYNENPEHEFLDIGYNVDVLTALEEGIGVIFEKYTHAFLFLVILHYCQQSKVDGAKFVQSTRAFCTVNGKRYKKLFSLVPLPLIANSKWQTEQPRYFGNVDSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Q3</accession>
    <name>A0A232F2Q3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_000918</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01001214">
        <property type="protein sequence ID" value="OXU24707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2Q3"/>
    <dbReference type="STRING" id="543379.A0A232F2Q3"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000642">
        <property type="entry name" value="Serine/threonine-protein kinase srpk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="201"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="442"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="511"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="791" mass="87885" checksum="D827BF0F92B9F4C8" modified="2017-10-25" version="1">MNSKTDVNRRVFAIKAKKKRHKPDKRKGKGGGGAVAATAGGTPAAGSASAAQGAGDSDLQSPTQQQQQGKNQPSRHGQTTSGFCQEPWYRQNDGQSYKGNGNRKFMNIYFIILLDCPNLAKLKLSTSLMDIFLNFTLNDELNKVNTHFCIKLDTCHSSSNETIEDEDDMYSSEDDEQEDSTDYCKGGYHPVKIGDLFLNRYHVTRKLGWGHFSTVWLCWDLQDKRFVALKVVKSASHFTETALDEIKLLKDVRDTDPSDPKRNKTVQLLNDFKISGINGLHVCMVFEVLGHNLLKLIIKSNYRGIPRNNVKRIIRQVLEGLDYLHNTCQIIHTDIKPENVLICVDEAYIRKLASEATELHSLGLKLPASLISTAPKEFQEPVPNSKMSKNKKKRLKKKAKRQNELLKRQMEQIEEMEEQNKPLIHASDGNFAVAEFKENGEATTPNAINVGGTDGNNSADQELNSESIEDNTESNKESPDDMSEPSAPLMHVNGIESVDVANAAASVAAGNNDVNSNNGEAPTMTITTGTTNTGTTTTTTSPMSEWNDKENAEDEDEEHGEIQKLKKPKNAACDIEKGGGEGVNLLADTEDVEDCGDGDNAQPLDRKQLKRASVAPLDPALVDCDVEVKIADLGNACWVHKKFTEDIQTRQYRSLEVLLGAGYSTSADIWSTACMAFELATGDYLFEPHSGEDYCRDEDHLAHIIELLGEIPRSIALSGRHSRTFFNKKGELKHITGLKPWGLYEVLTEKYEWSPSDAREFADFLTPMLKFDPDTRATAAECLKHSWLQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F325</accession>
    <name>A0A232F325_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001093">
        <property type="protein sequence ID" value="OXU25154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F325"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="27490" checksum="38FEA69A67D0665C" modified="2017-10-25" version="1">MITFYKEGLLEIVRFYADKKVMKKIEFLYHTHVAVLPLVSRYIQTLVYEKINDPINTPNSHFKHRNNKLEFKRLPRKILPPENPLVSSDREDPRIYLPRLGRRTARKFLGNIGRIQRPNLPCDSECRRSAPNCLPPFSRLIYSFVGVRARSSRAEASVVVAAERLPLFVMRQRHSRDKPMMDRPSDDLDVLLRVSRGENREKKRIVPLLWLPGVGVDMGFFIEGCEAMLNGMFSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3E1</accession>
    <name>A0A232F3E1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001154">
        <property type="protein sequence ID" value="OXU24963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3E1"/>
    <dbReference type="OrthoDB" id="10062823at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026776">
        <property type="entry name" value="UPF0729_C18orf32-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14975">
        <property type="entry name" value="DUF4512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="168" mass="19532" checksum="FFFD416A9F0ED730" modified="2017-10-25" version="1">MVCVPCVIVPVLLLIFRFLIQPILMKFWYRGKKNEEKKDAPELVKECKNGVCTLSWKSNKTDAKKTEYNTNIPSFDYFTFSKPEFETITLLSLIKLLAVLQSTNSWNLLIILCIFLIEIILIHLIKSFLFWDQVSSKVNMSIAVACEGNLCSFLEVQIQRYLPYRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3I4</accession>
    <name>A0A232F3I4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corticotropin-releasing factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001097">
        <property type="protein sequence ID" value="OXU25142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3I4"/>
    <dbReference type="OrthoDB" id="6418774at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000187">
        <property type="entry name" value="CRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00473">
        <property type="entry name" value="CRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Corticotropin-releasing factor" evidence="4">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="227" mass="24960" checksum="9CC1AE38E18525BA" modified="2017-10-25" version="1" fragment="single">RINGKKGTNNQLERSAREDVAFECSALRKLHNVNRGARHVMSLVSLLATTTLITLATSTPMILADDVAAAGPFGGAGLRAKIPVDHDHFLLIMLLNRRDFGVKSKPPLDETGGEYITSLDSDTSSSGGGGGFDTGGIAVSDLTRGKRIGSLSVVNSVDVLRERVLLELARRKAMENQQHLGENQYFFKSVGKRSGGFSYRDHRIARKKRLQYQLMNRQQEPERLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3J5</accession>
    <name>A0A232F3J5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hsp90 co-chaperone Cdc37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001030">
        <property type="protein sequence ID" value="OXU25416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3J5"/>
    <dbReference type="STRING" id="543379.A0A232F3J5"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="10">
        <location>
            <begin position="120"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="9">
        <location>
            <begin position="289"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="390" mass="45853" checksum="BD4D2F7639FF91AB" modified="2017-10-25" version="1">MVDYSKWKDIEISDDEDDTHPNIDTPSLFRWRHQARIERMEEREREKREHERKKQETLKKLQETMKRVAELESSKSDTTDLNTLKKALLDLEKEEERIKKEEEELKKKEKLTPWNVDTIAQPGFTKTVINTKPARTDDDADLPDEEKEKKMKQFIKENEKKLKEYGMLRRYDDSKKFLQENTNLVCENTANYLVIWCINLEMEEKHDLMEHVAHQCICMQYILELSKQLDVDPRACVGSFFSRIQIAEVEYRKSFDDELRLFKERIRKRAAEKIAEAMKEVEEEERKARLGPGGLDPVEVFESLPRPLQKCFEVQDIPLLQETIAAMPEEEARYYMKRCIDSGLWVPDANKPKEGDEASEETTVETPDANKSKENDEASDKATTGTPDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4P8</accession>
    <name>A0A232F4P8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRKR-interacting protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000950">
        <property type="protein sequence ID" value="OXU25764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4P8"/>
    <dbReference type="STRING" id="543379.A0A232F4P8"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30686" checksum="55F0714BD130725D" modified="2017-10-25" version="1">MPKDSSDDEKDAERPLVAKTAVDLQRLKVIKLMKNPEKPVIIPERPKSKNTPAVPEFVRNVMGSSAGAGSGEFHVYRHLRRKEYARQKFIQEKGHKELLDEEYHKKLEENKKLADEATAKKRAKRLKRKQKLKQKKFKPSDKNKVKNEDSSEKSNSDDSSDEEKLNDENVTKESADSEVKAEPEMSDANVMQTDSENQITVDVNQEESSTEVKSEAQVKEEISDARDRESTSASEVINKANMKTENDSACKESDNDSEKKSKEVKDEDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5L5</accession>
    <name>A0A232F5L5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000950">
        <property type="protein sequence ID" value="OXU25770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5L5"/>
    <dbReference type="STRING" id="543379.A0A232F5L5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28124" checksum="F4072157006307D6" modified="2017-10-25" version="1">MKLIVSNVEGVKEYLLHPERRRWLRSHPEMPHRARCIICDRVINAHLRTINDHAMSNRHLRILEELGPDENVYIDEEVFMREVAKVKLTLAAFFARHNLPFQLIDSLLPLIIHISQNVDALREVKMKRTTLTKITKNVLAVSHKTDLFNALCQYKFAIKFDESTDICSEKHGCIIVQIFNDKLNKITSALWDVVPIYKDDEEENDATAETMYRIIINSFNDFQTIPPENLIAYSSDGCSTMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6E6</accession>
    <name>A0A232F6E6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2452 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000900">
        <property type="protein sequence ID" value="OXU26018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6E6"/>
    <dbReference type="STRING" id="543379.A0A232F6E6"/>
    <dbReference type="OrthoDB" id="9995764at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019534">
        <property type="entry name" value="DUF2452"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14553:SF1">
        <property type="entry name" value="SIMILAR TO CHROMOSOME 1 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14553">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN C1ORF50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10504">
        <property type="entry name" value="DUF2452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22525" checksum="EC7036BA1E9AA0DB" modified="2017-10-25" version="1">MVFQCLKRPLSITTMDTADCTPSKVAIVERNVVPQGLQLVNPKTVARKAPNDLVDLAKEIQKADSFVKANACSKLQMIAEQMRFLQQQAEQVLLEAKENTSLHHAACNFVKHPGKIYHLYQRESGQMYFSMLSPEEWGESAPQQMYKGSFRLEHDHSWTPLSKVNIRDEELAILNKLYQSAENSTNASLNEYMSIDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6J5</accession>
    <name>A0A232F6J5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000853">
        <property type="protein sequence ID" value="OXU26202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6J5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="274" mass="31625" checksum="E115A99DDE7E6FBD" modified="2017-10-25" version="1">MVSFSKTLRSSKPMGHVDRTSLKKACLELDEARIRELIEEGVNLNGSGHLASLMMVSLTIIRRRHEPGMDRIARRLLRLLLDSGADPNRTCNSPEGDGNTTIFQTIVCYNLPYPEAAVNLPRIILQHVAFIGATTNRQIFNEVNNAYIQANSELLSFYTKCQTELTVMRNFKILEWSLESITFLELLTKPVSEVSRFTFIEQFRNSFYATYRVLFPVYASQLKEKYDEADAKRQRVIRFELIMRGTLNFEDNSFYDVLFDSFSEEEIDNFIGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6T2</accession>
    <name>A0A232F6T2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_013690</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000855">
        <property type="protein sequence ID" value="OXU26190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6T2"/>
    <dbReference type="STRING" id="543379.A0A232F6T2"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="17">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU26190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="506" mass="55663" checksum="01359DA12E978A08" modified="2017-10-25" version="1">MVLADLGRKITSALRSLSHATIINEEVLNSMLKEICAALLESDVNIRLVKNLRENVRSVIDFDDMAGGLNKRRMIQSAVFKELVKLIDPGVKAYQPVKGRPNVIMFVGLQGSGKTTTCTKLAYHYLKKNWKACLVCADTFRAGAYDQIKQNATKARIPFYGSYTEVDPVVIAQEGVDMFKKEGYEIIIVDTSGRHKQEESLFEEMLQVSNAVQPDNIIFVMDATIGQACEAQAKAFKERVNVGSIIITKLDGHAKGGGALSAVAATQSPVIFVGTGEHIDDLEPFKTKPFISKLLGMGDIEGLIDKVNELNLDDNEELLEKIKHGQFTLRDMYEQFQNIMKMGPFSQIMGMIPGFSQDFMSKGTEQESMARLKKLMTIMDSMNDSELDSRDGAKLFSKQPGRIVRVARGSGVTEKDVKDLIAQYTKFAAVVKKMGGIKGLFKGGDMTKNVNPAQMAKLNQQMAKMMDPRVLHQMGGMSGLQNMMRQLQQGAAGGLSNLMGGFGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6Z9</accession>
    <name>A0A232F6Z9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000838">
        <property type="protein sequence ID" value="OXU26250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6Z9"/>
    <dbReference type="SMR" id="A0A232F6Z9"/>
    <dbReference type="STRING" id="543379.A0A232F6Z9"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="272" mass="29848" checksum="02B6B1A0B7EB497A" modified="2017-10-25" version="1">MAAHFLNRIGQFGLGVALVGGVVNSALYNVDGGHRAVIFDRFVGVKNNVTGEGTHFFIPWIQKPIIFDIRSRPRNVPVITGSKDLQNVNITLRILFRPVPESLPKIYTILGVDYDERVLPSITTEVLKAVVAQFDAGELITQRELVSQKVSEDLTERASQFGVILDDISITHLTFGKEFTQAVELKQVAQQEAEKARFLVEKAEQQKKAAIITAEGDAQAASMLAKSLGEAGDGLVELRRIEAAEDIAYQLGRSRQVIYLPPGQGTLLSLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7X0</accession>
    <name>A0A232F7X0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_010714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000809">
        <property type="protein sequence ID" value="OXU26397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7X0"/>
    <dbReference type="STRING" id="543379.A0A232F7X0"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="181"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="423"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU26397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56753" checksum="AC15BBC342DC0AD7" modified="2017-10-25" version="1">MALRARRSSSESSVVVLPRHRVGATGRSRFSPRGLLAAQQRRRRHYEPLDDTRSVNRVRSAVSSSSSNSSMASTDDNKMQQETLKTSSEKRENVENSCNDKAAFGYGTTIPPNNEANEKDLASKKVIFCVHGKLSGCCTLVKGGSAEDCAPIDFRSNSTPFEDHCHRERNEDIDKKARKKLIIASVLCVVFMIMEIVGGVMSNSLAIATDAAHLLTDFASFMISLFSIWVASRPPTKKMPFGWYRAEVIGALTSVLLIWVVTGVLFFLAVERIINKNFELDASVMLITSAVGVAVNLVMGLTLHQHGHGHGGHSHGHDHGHDHNHGAVKGEKSDHDHEGSGELETSHKHRATDRNINVRAAFVHVLGDFIQSAGVFIAALVIYFKPEWSIVDPICTFLFSILVVLTTVAIIKDVINVLMEGIPKGFDYSQVESTFMQIDGVVKVHNLRIWALSLDKTALSAHIAIRPGVSPQTILRTATRNIHEKYSFFEMTLQIEEFDEQMENCKQCKPPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9D4</accession>
    <name>A0A232F9D4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000598">
        <property type="protein sequence ID" value="OXU27474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9D4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="381" mass="43185" checksum="88BF8E140B02813E" modified="2017-10-25" version="1">MAPKKPCAVMFCPSGRYADAKSRKMFGLKQTSLFKVPDRADLRKKWSSLLYTGLYDDDVVCEHHFRDEDVIRTITRRIGGKLLNIPSRRYRLAKDAVPMELDRKKPDRSEGSNDNQAMSENSTIPAVVDSCQAEQSNVDVQEDSSIDEIRSSTPLLPEITDDVGDNCLSILKATVSNIADDYKGLEVEILLTESCESLETTSNDDTEEIDVTDTSETIKDYCSTNPLPPSWSWYQENDKILFAQLNAKKREIRCFVEYHFNLHAKVFTADNRQIHELSRGVWSIADLIDLFKKIEAVIVCEGSSGAKSRSDECCGIVKSDSNNAKYVHHTSCLPCRKLKKASSMNKGGRINKLPSKKQMKKRQDKWLEKILTHHMLSILHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9E3</accession>
    <name>A0A232F9E3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000598">
        <property type="protein sequence ID" value="OXU27481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9E3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12688" checksum="241106AADFE52B4B" modified="2017-10-25" version="1">MSAFWTCLEGTYGIHIPIYVQNIMHIMGYDNPVSFQRITPAKLKEIEDFMRSINFSPPIDARSEDYFGIFFAHERENFSFTPGDKDLILGLVDRVKEYSHIFKKLLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9U3</accession>
    <name>A0A232F9U3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000569">
        <property type="protein sequence ID" value="OXU27624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9U3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="148" mass="15874" checksum="3F0833677E0A4B72" modified="2017-10-25" version="1">MLRLKLVGLPTLPIYGGCVDSSLMSVACSSSSNLTRRSIANSFSSSRCLTRRFRLDGLESKCHLPVLGAAPAVVIAAFANCREPCCTNINRGVDLALLCYSSPACPEAINPYQGSQDKMFADVEHAVVYSLDSHVVFVMIHTSACVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA06</accession>
    <name>A0A232FA06_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000557">
        <property type="protein sequence ID" value="OXU27684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA06"/>
    <dbReference type="OrthoDB" id="6582325at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144674" description="Protein sleepless" evidence="8">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18195" checksum="3275A6945987DB80" modified="2017-10-25" version="1">MCFKKMSVSSAIAIALLVFYSVDQASALKCYSCESFTNGPCWTDPNSGATKNCGANGFSQMLESSAIANATVRTALLSGGSDDGISTRVPREADCAKFIGTFDGQKYIAKTCTVKSISCEYYANYLESHIGFKVESCDRCDGDFCNSSNNLNAGIMCLAISIILGFFCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBV6</accession>
    <name>A0A232FBV6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000448">
        <property type="protein sequence ID" value="OXU28311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBV6"/>
    <dbReference type="STRING" id="543379.A0A232FBV6"/>
    <dbReference type="OrthoDB" id="7696924at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="193" mass="21775" checksum="D230868C97999CD2" modified="2017-10-25" version="1">MTGIRLITVFGTKRRKGTFNDSDAPRTEDDSEPGTFKIMFGFEDAEDINAEPRVDNNADQMIDPDMPADQIALEIEPAAAEKDAQEGRQLRDRRRIPTPDRYGVPIAYLDDSENASKWECAMDEKMQSVRENNTWTLSTLPNCKQAIGCKCIYTVNSDATGNATRYKARLVAKGFKQREGIDYFDTFAPVGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBW0</accession>
    <name>A0A232FBW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_001524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000501">
        <property type="protein sequence ID" value="OXU27970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBW0"/>
    <dbReference type="STRING" id="543379.A0A232FBW0"/>
    <dbReference type="OrthoDB" id="10029564at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06741">
        <property type="entry name" value="PDZ2_FL-whirlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000087">
        <property type="entry name" value="Whirlin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="177"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="513" mass="56471" checksum="1754168D3EE13F7D" modified="2017-10-25" version="1" fragment="single">MASTAEDYGSELQELQWGGNLPTASVQAPPVPQALSLQELTVRTIMMTREPPDSHHGFGICVKGGKDAGVGVYISRVEEGSVAERAGLRPGDTILEVNGTPFRAVTHEEALKMLKSCRTLSMTVRGPAIDPRCRGGHPIWPQNRQQTCSWMDRQGRPASPPPVNPPRDSRYGPRTRKVDLCIEPGQSLGLMIRGGLEYGLGIYVTGVDKDSVADRAGLLVGDQILEVNGQSFEEATHDEAVQILKTNKRMSLVIRDVGKVPHSCTTSQPMVVPVSRYQDHDSLLLESPGNHRPPSPASSLNDWRHRGVHPISAATAAMVEEKARLLADYRTRRLTVEDLVVSLGDLLNTHEKLTLLTELRELVDSKDRPAFDDLVYRPRLSRRKGDRAHNSDLIVTPSLHELPRVISGACCRPGRLMDVEGDPLGVTGPLLPRENQEYRSPSEDSGLGPEMGSRTSQQHQVATSDLALSNDDEYENQDYEDDMEGERGGRRHSSPGGSRGNRDYHHHLHADNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBW5</accession>
    <name>A0A232FBW5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000509">
        <property type="protein sequence ID" value="OXU27939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBW5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012918040" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7458" checksum="D05C0F62FFF2D4AA" modified="2017-10-25" version="1">MRQSSTLRKIRSCLVLTVLTSCLQETPKKDLSKEIIYVVGSDEVQGCMVDADIGRMLSYSRFSGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDG1</accession>
    <name>A0A232FDG1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000427">
        <property type="protein sequence ID" value="OXU28479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDG1"/>
    <dbReference type="STRING" id="543379.A0A232FDG1"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13337">
        <property type="entry name" value="FERM-like_C_SNX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06885">
        <property type="entry name" value="PX_SNX17_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.60:FF:000001">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000145">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000008">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048763">
        <property type="entry name" value="SNX17-31_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048767">
        <property type="entry name" value="SNX17-31_FERM_F2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040842">
        <property type="entry name" value="SNX17/31_FERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037836">
        <property type="entry name" value="SNX17_FERM-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF14">
        <property type="entry name" value="LD15323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21273">
        <property type="entry name" value="SNX17-27-31_F1_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21271">
        <property type="entry name" value="SNX17-31_F2_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18116">
        <property type="entry name" value="SNX17_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="482" mass="55237" checksum="868B1EB7BA62658A" modified="2017-10-25" version="1">MHFSVPDTQELIDEAGNAYLGYNVHINGLFHCTVRYKQLHNLHEQLVKDLEVPLPSFPPKKFFPLTVNQQEDRRLSLDKYIQTIGQNTSINNSELLNGFLLSAQLESAVGLVEDENVDVFLMNGLKINLDVTVAENSGQILKKVCKQIKLDEKLCPYFSLFIVYQDEENFVVLRKLQDFESPIITQRNMHKMGTRIVIGKWYWDVAFDFEMLNDSVALNLLYIQANAEVERGWIPATEELKRRLNTLKERNAKEEYLEIVRSLKYYGYIQFSPCLCDYPQAGSKVLVSIGKNELNIRIASSEGDQEEVGFKVTRMRCWRITTLHEGNDKYEETPECGLELSFEYLMAKDHLQWITISSEQAILMSVCLQSMIDELLLKNVGGVKNQEVTGKTWTYITRDGYSRTVVGSPSPESFNKNTKENDINARTKTEPIIKKITERFSAVKVKKPNAAKSPIPNQERRCNSDGDLLENNAFCMIGDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDH2</accession>
    <name>A0A232FDH2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000389">
        <property type="protein sequence ID" value="OXU28735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDH2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7502" checksum="C635DB2FBFB3D181" modified="2017-10-25" version="1">MTVPVDRLPIPTITDSTTECPNRFSTVSISITVERHLLHAHQSTSAGIRLSRVKSNRLLYKLLNIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDI0</accession>
    <name>A0A232FDI0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Titin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_000836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000435">
        <property type="protein sequence ID" value="OXU28407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDI0"/>
    <dbReference type="STRING" id="543379.A0A232FDI0"/>
    <dbReference type="OrthoDB" id="6107607at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001806">
        <property type="entry name" value="Blast:Twitchin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000612">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001223">
        <property type="entry name" value="Sidekick cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF167">
        <property type="entry name" value="MYOMESIN AND MYOSIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="84"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="190"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="283"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="382"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="967"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125357" checksum="86011526E553BF8E" modified="2017-10-25" version="1">MGNAQRKAAHHPSKGPYVPSNSAKKVHWDGPEFQIRIKKITEDPEAPKSRATRNLATLELARRMHDDLRRTLVFMSRLQGLPAPPGKPILIPGEEDAQPDVVGIRWERSPSNGGSAIIGYHVEHRKMGSPHWVRSAPVLCTFPELTLSGLEPGWRYQFRIRAQNALGLSEPSELSDPLSVTLQRTASSAPRFDLELRDCVALEGEQAEFEVIYAGTPLPKVSWFKDGFEIFSSRRTTITTDSGKSVLIIQRTSIDDEGEIKCSATNRAGHISTRAKLMIEAPPHVRLPRQYEDGLLFEQGETIRLKATNGGRPPPSITWYHNGEIIIVDQRHNFESITDNETILKIQDAKRQDRGEYTIRAINKLGEDVASFLVTVTDRPAAPGKTIVTSTLGRSVTLAWKEPDDDGGCKIGTYIVEYYRIGWDVWLKAVTCRQITATLNDLIEGSEYRFRVKAENPYGVSDPSEESDIIFIPDPKRGITEPNMRAKSASHRDIPRGRSERREVSFNEPAQRTRSLTREEASHREAMSAYERTASSQRLLASAQQQPQPPPRPSRADSRVTFALDTTSREKDEPKRQWSKELLPQPGELEILARGTSQQTAVVITPSFDDSGGRHRSFIESRSRSVSFSRDHSPSPLDLEETTEIAIKERVESMTLRGQLSPPRTPRRRRSSGEIRDANSLRTLRREDEETMLHGSSEFMLVLYPGEEDGQQHEASRIEKAAEAMRRDSREARNNQSVKQQPAVEAPEESEEEDLVPPPMSISLPELFSADHQVVEIFREAVSSTELLHERAMERFYKAVEAEKSQTKSQPTDVNKLKPPGEGEGYPLFSGRTRPVRRRLSNSGANATTWQLKRDRRRSSEGQAKVELLKTPQVPTVRMPLQNVSSDPNLPTSDEMLAQKNPEPWGLGCGLGDSAERLRRWHEPGMDLSNENSIAEMINKENFQNKQKEELLKLPDLNIREPMKVEEEYDEVAPDTGEILAEDSIETSGVSSEAESTDSEDLKQLKARIMAIPVVDEADTYNPRGRMVVHSEQDVPPPVPPHRVPVVDVSPPIPDRRSMSPTNLTPASSNSAIVPKSILKKRTETEPVPTNQFGRPIPPEKPIRKSLPAYDDIGMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE99</accession>
    <name>A0A232FE99_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000365">
        <property type="protein sequence ID" value="OXU28863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE99"/>
    <dbReference type="STRING" id="543379.A0A232FE99"/>
    <dbReference type="OrthoDB" id="7550162at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="241"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="585"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="790"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1049" mass="123294" checksum="132C93563A787F2A" modified="2017-10-25" version="1">MEKIMFEIIDKKTDEFPKFRFSCETVVVKCLTDSEDGLDDCWKKLFKNITCKYDPNDSISINVSTDSVELEPVSEVFKPVSSYDDAEFSNFMRNAVSNYKNFCINDDIKIVVSCLLTSQRALELSVSQTSHKPNDTSEDDQLSYISYEKKYEKSRNSEPDHAFVFYDFETMLENTKENEKHKIHKVNLCVAQQVCDKCNEPGRLDKSIHCNYCGRGNVRIFKENPVESFVNYLWNEKRPTNIEAVTCIAHNSQGFDCQFILKHLIERRPRITPSFIVIKGTEIMYMSIKNPYNIQIRFIDSYNYIKEKLEKFPEIFEFVDDDCVKGKFPFLFNTPEHQNYKGPVPEEKFYSPGTMSAEDLQKFESWHTQLREDGYQFDFQSEIVSYCETDVDILRRGCCDFRQKFIELTDMDPFGLYMPVTLAGFCHKFYIEKILPEVYRKNPAKEKIGLMPDRGYRKRSKNTRESLEWLLIREKETNSEIIHIGRGHEYRLPELDIIVNGFSKSENGKETVYRYYDCTRHGCPECRVPSQMNNYEKIVKMSSKIRNFGYRLEEMWSCRFKKIKAKYEEFLSDHDNLYSDALNPRDAFFGGRAGNAVLVRSVKDNEKIRYIDVCSLYPYIQKYGKYPVGHPDVKIGHECDKYVGTKLEDVEGLVKCRVLPPRDLLYPVLPIHLNNTLMFPLCRKCCDDLVESNCTHDEKGDREITGTWVSDELKKAIDKGYEVTAIYEIWQYKTVQYNRETKSGGLFADYVNKFLQNKQEASGWPEEFDTSELREEYLTNFFEREGIRLDREKMKKNKGLRYIAKSCLNSLWGKFGQRNYPETRFCETENELIEVASDKRLALETVVPISETDLYYKYRDKKKDITPKVRMNVTIAVYTTAQARLKLYEYLDELQERVLYYDTDSCFYVTENDDQIVPTGQFLGDMTDELMEHGMGSYIREFVSLGPKRYSYIVVKPDKSEKIVTKISGVQLNSSNGDKFSHENIKKLAEGRIKEIEHTSEEIRRTRQHDVVTKPVTKRFKATQVRKRIFTRNDESYPYGYKRFRRSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEE6</accession>
    <name>A0A232FEE6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000374">
        <property type="protein sequence ID" value="OXU28809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEE6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="71" mass="7888" checksum="2ABADAF45C80DDC7" modified="2017-10-25" version="1">MATTEVFQDWDSPHDSITSISRKTTRKTTKTTSRREIYEDDNDESYPATAAAATAVADDDDDDDDDDARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEF2</accession>
    <name>A0A232FEF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000333">
        <property type="protein sequence ID" value="OXU29141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEF2"/>
    <dbReference type="STRING" id="543379.A0A232FEF2"/>
    <dbReference type="OrthoDB" id="6347385at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62176" checksum="8364CD1E57658534" modified="2017-10-25" version="1">MSESRHLRSVSDLYAADEIEVLLLEEIRDLEPPPAAYSRPEDIQDFEIVLNKKIKINNMRSTEVSNAIDLNAAGSRTGGRISSQSSELDSPGIHSTVHSWNSHTNYGNYGHDHPHGSSANAMPWPRSSHLIFYCDVQGHLKTATGLVRLLLLIRSPGLKFLESPLERWKNSISRLSSAACLATLCSSGTAKVSLFMLPLVGRLRFMIFVAVFCLLITALLLFLDISHVVYFFPFNWARLNAWIFTSVGISYTTSSALLALSVFDYHGAGWVPRRTRSQLTATAALGLSCAILSFLLSWLHGRHGSSCHAPPGEDDPTQQLYKPVDSSSSGATLKDGVRSTKQPPPWVAKNSKKHRTSMDSNNGNNKPRKDHWASARDHFLNTNQFDEELENQGTSAAADKEKDQPEPERRRQRRRRDADGSSGTGGNMTASQTKTSFSTDESKKKAPPKKLPIQSADKARPRNSKDGAKKTTTRTSVTRSEIQEYWMQGYEHVQRTDKTTANIEQWQSAAMKSLEEKKAKDERWAESWRQHKDQKEPAQPDDAKPCSSKTLEPLNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFC3</accession>
    <name>A0A232FFC3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000323">
        <property type="protein sequence ID" value="OXU29220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFC3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8281" checksum="63CBC305F61AE87A" modified="2017-10-25" version="1" fragment="single">GVIFGKNGLEQIDWNEYFRIVTKSARSLLHLVEKAKIKGEISVGALSQYSGAREKISTLSSVAMDLGGFRSFRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFF8</accession>
    <name>A0A232FFF8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IgGFc-binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000328">
        <property type="protein sequence ID" value="OXU29188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFF8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011991541" description="IgGFc-binding protein N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="86009" checksum="DB760406302B4694" modified="2017-10-25" version="1">MWKLSTTFVIFSALFCFSHCQTNYVDVSNHVRSFQGKFQDHPFFVTIDNQIYTVTINSERADSGYTNQLILTSIDNDSKQQQKKIKGELSLPVLSSIEIFSQKVVVLGNGKLVIVTRKQSTPEKDFALLITIDPFDYSTQTAVKVEYGSKYMDVMEVIPYHDTYDVFYKYYVYDDGANLPKNPHRYNDQGQHIELDYSVETYANVFANFQINAIKAFDASEGYYLTYFDHANKDTTVLQRLNSRYEKVKEVRLSANYIYISTTQGHINYCFFADEKPTCKFLNVDLEVQATSELPGFNYPKGKRVEIIRVVNSPKQGLVVFIGFENPQDAKLCDFFIQPVGSDGSAETPDHLMSYTMLLHRSAILLCCAILTINQQVGAVEVATFTRQWSTNFTYKPEVVQVQDDVYLVSLQNYTVNITSINSSIPILACKVPVSSEKTISSKITPVALGNGKILIRGSMTTTKIDNPNKVRPVDQLFVIVDPRDCSTIKIVAQFPSHPRYFEAVVPYENTFDLFYSNSSNKTEDTTTVPKRYDDNGEAIPLDYSLAPEKDIRGLVIHLLKPYHQSGGFFAAFVQDDGLVGLKLLDSHMKVLKESVSENAVDYVSTLHDHVTYCYVTPSLLRRHNAVRRQQIFCQLLNSDLKPKATVKLYDPEGVYVVDAEVVNLPDGGAVVVLAHKHKNPQSEQNEQPVDFYLQRINPDGTTREAVKIGTYPTYYFMMRGVLHRNSEFCLVVVGESQPRSTPTTDLNFGVDVKCVDTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFT7</accession>
    <name>A0A232FFT7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000265">
        <property type="protein sequence ID" value="OXU29624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFT7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="10049" checksum="0EF0284291945911" modified="2017-10-25" version="1">MPSSSSPFEVYTAEVPHEFGLYKYILRFNPPYCLSIDEYNWQAFSYSHFENPGITKLSEDNLTITAPTRRRLLSKPASSRSSIQLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG20</accession>
    <name>A0A232FG20_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000317">
        <property type="protein sequence ID" value="OXU29267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG20"/>
    <dbReference type="STRING" id="543379.A0A232FG20"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000230">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000310">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF53">
        <property type="entry name" value="DS CELL ADHESION MOLECULE LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="829" mass="91872" checksum="E5DFB9997ABA487D" modified="2017-10-25" version="1">MWRNTPVGGGSLRSAILLFISSMFMLGKSTLLSTLTVSAEDETMGPIFVKEPPNRVDFSNGTGAVIECQARGNPQPDIIWIRADGTAVGDVPGLRQVLPNGNLVFPPFRAEDYRQEVHAQVYICLAKNPVGSIHSRDVNVRAVVAQYYDTDVNKEYAIRGNSAVLKCVVPSFVADFVTVLSWHTDQGEEFVRNTDGTEDYVVHQYYQSEVNNEYVIRGNAAILKCSIPSFVAEFVQIVGWQDDQGNSFNMGNESGIVTQYYEAEVVSEYVIRGNAAILKCTIPSFVAEFVSVDTWEGSDGSSYKMSHDYGTHLVTIQPLDAILSLALSLKCAYHPEIMTEYVIRGNSAILKCSIPSYVAEFSYVTEAENEYVIRANSAIMKCKIPSFVSEFIYVDQWVASDGSIYTPGREHAVSQYFEVQVYDVFAIRGNAAIFKCQVPSFVGDYVIVAEWISSNAESFTFDKQSYVVGQRYAVNVMDEHVLRGNAAIIKCHIPSFVAEFVQVDSWLEDDATEIYPGRDYDGKYLVLPSGELHIKDVGPEDGYKTYQCRTKHRLTGETRLSATKGRLVITEPVGSVRPKFPSLDNLRGLVTNVGKSLPLLCPAQAFPVPSYSYFFFMSVSMFVEPVAGVRPKFSTSENSRTYTNRFGEPLTLFCPAQAFPVPVFSYAQWRDDSSMSCPRVSCSDVQVTCYNNKQKLKYGFVYTNIEPASSTRPQLAGSSDLQRFTTAVSKSVTLHCPAQGFPVPLYSIIKNLDVDTAVTPKGFPSRTYAEPASSTRPQLSGGTDFFRFSAAANKSVTVQCPAQGFPVPLYRTSWQCSTKVSDYGNFNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGD5</accession>
    <name>A0A232FGD5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000233">
        <property type="protein sequence ID" value="OXU29826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGD5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="158" mass="17903" checksum="694D1D25A249E173" modified="2017-10-25" version="1">MKVRLCLIFPSKQTSAENLLIEKNSIRRATRKKTSECVLEYPPIRREEGGREGARVAEGCSLIALRFHECVCACVHNQAEEQPTPRPREVHGIPGRLFPSRDSILPVIYRSFGVRGVVPRTAKGDCVDYFWSSFADQGTAGRYNALYWGRLMKSFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGH2</accession>
    <name>A0A232FGH2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cilia- and flagella-associated protein 299</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_007755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000281">
        <property type="protein sequence ID" value="OXU29529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGH2"/>
    <dbReference type="STRING" id="543379.A0A232FGH2"/>
    <dbReference type="OrthoDB" id="2136125at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027887">
        <property type="entry name" value="DUF4464"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33588:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14713">
        <property type="entry name" value="DUF4464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU29529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="310" mass="35932" checksum="5987D15EA91C62F2" modified="2017-10-25" version="1">MMKNERSSADLNLTGADVLVEKRGDDVLGGSFPEAVASDYQKVLSTVELDLLDLRLTRHESCFLDIVLIKLLNDSESAIKISSVNMIHKNTQILSDQELLNFRDYKDYLESFITPRDLFHLRSKSIARQIIELGYHTEGTLDRETFEDRVKTIKRYLYLKENPYALCSESIELNDIFLQELGLREKANRCGKTYTIIFMQHFGKSQSQISAYIDYCHRLRAEDWLPYFQGNKKLLPRKDDLSYYDWKAGKSILNESQNFKPIVDGKNGLVFQNTHDLKFVDPNSAFLARTTIYSELYGPIVLYDHNVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGT6</accession>
    <name>A0A232FGT6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000241">
        <property type="protein sequence ID" value="OXU29773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGT6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9527" checksum="4972DF3C1581C3D3" modified="2017-10-25" version="1">MECLFIAYLVLHRQGRPLLPEPNERPHDQHQVLLVAQPAGALLQDVRGVRQVPGERQKVSNAYRFSPPPAWKRGRVGLAISGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH82</accession>
    <name>A0A232FH82_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000219">
        <property type="protein sequence ID" value="OXU29923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH82"/>
    <dbReference type="STRING" id="543379.A0A232FH82"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="328"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="409" mass="45530" checksum="A5412CB704BC5F0E" modified="2017-10-25" version="1">MTTSILNTWAHRMHFSPMLNVYFCSKQFHTLVKIRRPEIFCTPMMDSFRRLDEFENHAVSVLPPSIRDYYVNGAGEGHTLKINREAFRRLRIRPRLLRNVSNRDVSTTVLGQKVSMPLGVSPTGKQRLAHPSAECATAKATESAETVFILSAFSSTRIQEVAKAAPKGIMWMQTMLHSDRDCTLHCVRRAEEAGFKAIVLTIDNAVLPKNKAHILDDIPDLSTAVYEDYFLTKMTAEEMGNVHLQIRKIIDQSLTWEAVEWMTSVTKLPIVVKGVLTSEDALLAVKHGASAILVSNHGARQLDGTPAPIEALPEIVKAVGDKVEVYVDGGVRQGIDVFKALAIGARMVFIGRPMLWGLACGGEEGARAVLEIMRREIDETFALAGCSNVEQISRDKDLVVHESYYSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHR9</accession>
    <name>A0A232FHR9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BolA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000194">
        <property type="protein sequence ID" value="OXU30103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHR9"/>
    <dbReference type="STRING" id="543379.A0A232FHR9"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.90:FF:000001">
        <property type="entry name" value="Transcriptional regulator BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050961">
        <property type="entry name" value="BolA/IbaG_stress_morph_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229">
        <property type="entry name" value="BOLA TRANSCRIPTION REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46229:SF2">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15211" checksum="42849283CC5BA861" modified="2017-10-25" version="1">MLRFLARKTPGYNFSCNQLFRNMTDLVHPKPVETSIRKKLKETFLPTHMDVLNESYMHNVPKGAETHFKVVVVSDKFTDLPLIKRHRMVMDLLSDELENGVHALSIVAKTPSQWEESDKSVKPSPNCRGGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIY6</accession>
    <name>A0A232FIY6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein adipocyte-associated 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0359 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000159">
        <property type="protein sequence ID" value="OXU30439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIY6"/>
    <dbReference type="STRING" id="543379.A0A232FIY6"/>
    <dbReference type="OrthoDB" id="10027388at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018781">
        <property type="entry name" value="TPRA1/CAND2/CAND8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15876:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10160">
        <property type="entry name" value="Tmemb_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU30439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75626" checksum="9C6AD2282169BD52" modified="2017-10-25" version="1">MRAPSRRERDDVRCCLGERASGCSSLQRSTRFGVSTTGAPGGPNAEPLSQTILNSRSTNFKMYGDGEMEVSEGWRQIRDLSTTTDPNISSTVHEEDHFCKLILYKEIRDSRVRIWDVIILIPNVLFLLFIGVRFNRARLKLRATSSPIYMAFYGLVVCSVVISVVRCIVSMTVDATENVGGIVDKVLWVTVRFFLLSTEMSVVIFGLAFGHLDSRSSIRRVLLATSFIALLFTITQGTLELVLPDDTFHIPSRDFYVFGHGGMMFWFCSSIVFTMIYLFILVVPYTRLRERLTLPNRKGFYVYASLLATLDLVQSIGAGLLNYTQNQAGLCVVDLTAAMYLTLFTPVVYHTFLSDFLGVSQPSIMFSYKAQVDDAMDEDTVSLPHQQSFSSLKTDSDYIYQVHTPCFHAPLFHNPFFNSGYLATTSTSTTATSKPGPSRFYASSRLAGMSSSHASLLYQDYYAAQRRTFYPKSRLGGVRTSAPDLRSIASTSGTTPKRLQQDSRTVEATASSSNLLLSPSTASKFAFKPRKNDSKTNLFSSDENDELLEVEEKRQVTRIEKSRRGILGSDEIRQTKQEKTEEKRSASAAAGLNDYLRHMRNYSDDENNSNIEVENHSVYDSTQFDVNSTPVNPLYAASLQSPDSITGYSIDSSAQEFTHNQQQQQQQKEANGYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJC1</accession>
    <name>A0A232FJC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJC1"/>
    <dbReference type="STRING" id="543379.A0A232FJC1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46643" checksum="B2688C7319C33685" modified="2017-10-25" version="1">MKDKVVITTGGTSGIGLSIVKYMLKNEAKVLLQFRKKIKLSTLLYSNWKMKIRELFFDELQMQYRDRIGFYTCDVTNTIMISSTTFVMASYMLIDRIGKHKGGNGGVIVNVASILGLVNDLFTVLHNTESLDSVATAVIEREDGDESVWVVKRDEPAFLDKVAIVTGGTGGIGFATVQALLRHGAKYVAIFDLDSMHTRAASCIHKVEEEFGKDKADFYTCDVTIQSEFAARYDEIVGMQRTVDILVNYASIASEPRAHHMIDINLTAVVTCTLIGIDRMGRHHNGRGGAIVNVCSVFGLTTSPAFPIYTATKYGVYGFTKSLKDHYEHLGVRVMAVCPGLTETSLLHQNLKEETLNFIPEKYLNEAFQCSKYIQSPANVGAAIVKMIEEAEAGAIWVSEDNEPPYAVQDPEFYKDRGVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK46</accession>
    <name>A0A232FK46_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_016922</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01000130">
        <property type="protein sequence ID" value="OXU30697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK46"/>
    <dbReference type="STRING" id="543379.A0A232FK46"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01578">
        <property type="entry name" value="AcnA_Mitochon_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012443877" description="Aconitate hydratase, mitochondrial" evidence="15">
        <location>
            <begin position="18"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="16">
        <location>
            <begin position="215"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="17">
        <location>
            <begin position="733"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU30697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="931" mass="101551" checksum="A0EE4B22D9486A52" modified="2017-10-25" version="1">MSKALFIVLIGCAVAFASPVKRDALAERSIAEEVTKIGSGFKELIKEIFAAIVGQIGGAIADNLQGAFHKFGERLHTKEYKEAVQEFFETMQKLEEAEDKLEQETQEYLEKEADKVGEAFFDLVEQAYEKIKNNEEGTVNAEEFKKVVDEFKQKKVAGLAAEVQQRCFSTSPLTFAAAKVAMSKFDSTAYLPYDKLDENIKIVKKRLDRPLTLSEKILYSHLDEPQKQDIVRGTSYLRLRPDRVAMQDATAQMAMLQFISSGLPRVAVPSTIHCDHLIEAQLGGDKDLKRAKDINKEVYSFLKTAGAKYGVGFWNPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMANIPWELKCPKVIGVKLTGELKGWTSPKDIILKVAGILTVKGGTGAIVEYFGPGVDSISCTGMATICNMGAEIGATTSVFPYNDRMKDYLKATQRASIASAADQFKGSLLTADSNAKYDQVIELDLSTLEPHVNGPFTPDLANPISKLGAEAKKNGWPNEVKVGLIGSCTNSSYEDMGRCASIAKQAMKHGLKAKAAFNITPGSEQIRATIERDGISKVFSEFGGTVLANACGPCIGQWDRQDIKKGDKNTIVTSYNRNFTGRNDANPSTHAFVTSPELVTALTLAGRLDFNPLTDKLKGADGKEFLLDSPYGDELPSKGFDPGMDTYDAPPADGSKVRVDVDPKSQRLQLLEPFDKWDGKDLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNSENGEMNKIKNQLTGEWGGVPDVARHYKKNGIRWVAIGDDNYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGMLPLTFANASDYDKIQPTDKISILGLKDLAPGKPVKCEIKHKDGKVDTITLNHTLNEQQIEWFRAGSALNRMKEIAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLE3</accession>
    <name>A0A232FLE3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TsetseEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000068">
        <property type="protein sequence ID" value="OXU31330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLE3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624353" description="Protein TsetseEP domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34489" checksum="7FA40F1A0CC749C0" modified="2017-10-25" version="1">MKVFIVFFYVFLAANGNPLESKRNDRLKSVARTYLNRTAVMTSSIKDLREAIDNTPEKSKEKIISLIESEVSKYPKMIEIQKETNMRSAMRGFAHCRKFFKIQMQISKESLEEKLTNAVKTQLRMNEITLDNTEKFFPQRSEGVKCRVKLNHLSQKYPKTAKICKSHLFVTKRTNVASVINAVQKRTTLVTDRRDLTDITKIANNLQGRNLDNELELCQTKNIDECNLTGKYKTVINHSELVISNIQNITKLVVELAYKTKITEKGLSTESKNISNYLSRIGCIENPDDIEHENQLYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLJ5</accession>
    <name>A0A232FLJ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014952</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLJ5"/>
    <dbReference type="SMR" id="A0A232FLJ5"/>
    <dbReference type="STRING" id="543379.A0A232FLJ5"/>
    <dbReference type="OrthoDB" id="8247644at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU31379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41808" checksum="1DEA13349189070A" modified="2017-10-25" version="1">MCDDEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLV0</accession>
    <name>A0A232FLV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_002528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000068">
        <property type="protein sequence ID" value="OXU31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLV0"/>
    <dbReference type="STRING" id="543379.A0A232FLV0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF154">
        <property type="entry name" value="FI04917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="615" mass="68944" checksum="42256397FC02F39A" modified="2017-10-25" version="1">MVWSLGSNAAICSPNSTTTLCSPGMLQFLMFVTEFMGYSYDNQLNTTHQHEFPEYDFIIVGGGSAGCVLANRLSEISDWKILLLEAGDEEPKVASVPGLTNLFQKSSIDYDYMTQPETRACQSSPGRSCEWPRGKVLGGSSSINGMLYVRGNKFDYDNWERLGNTGWSWKDVLPYFKKSEDMKIPEVLEQSSEYHSTGGYQTVDGYQYQDEIAQAVRDAWKELGFEETDYNNGAQIGTSKVQFSSVNGARQSANGAFIRPIRGLRKNLVIRTDSQVKKVIINKRTKRALGVEYTDKRGKVRRAFARKEVILSAGAIDSPRLLMLSGIGPREELEEAGIDLIKDLPVGENLQDHVLIAPILIDLQNKTRAEISQDRVQNDLLHWLSAHKGPMADFGFLDVQTWFATSYEKQPNVPDIQMNFVSFLTGDSKDSYNILFPYYDKFLMSTNLVATKSRGVLKLNKTDPLGSQPMIYANYFSDPQDMAALIEGARISNAILNTTTFRRNGFVRTRLWAPACDHFQLDSDQYYECFVKHYMSSGLHPVGTCKMGSNSDREAVVNPRLRVHGIKGLRVIDASIIPVIPRGNTNAPTIMIGEKGSDMIKQDWLKNDYIVNSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM42</accession>
    <name>A0A232FM42_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000035">
        <property type="protein sequence ID" value="OXU31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM42"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="57" mass="6603" checksum="CDBB1A04B1348276" modified="2017-10-25" version="1">MKYQYHKTITNMILNMFTKRIRIRVRIAETGIQQNTGGELRKEGAGTITHVRTVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMC1</accession>
    <name>A0A232FMC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 1 beta central acidic region eukaryote domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000030">
        <property type="protein sequence ID" value="OXU31795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMC1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="269" mass="32381" checksum="BA84D49EB286068F" modified="2017-10-25" version="1">MESDGGSMRCVPDDVDQVKGKKIQRQFAIKYFGEDSEDDSQYLLQRKKIQQKKRMLKKFKNYFGEDSEDDTQYLQQCQTKKQKKRMLKKFREYFGEDSEEDTKYLQIDVPRIKQRKKKKKQQVSLKIQSRHRLILNKPVKASSICTDKYFGEDSEDDSPYLLQRQKNKQKKRMLKKFREYFGEDSEDDSPYCRQRQKKKQKKRMLKKFGEYFGEDSEEDTKYLQIDVPRIKQRKKKKQQVSLKIQSRQRLILNKPVKASSICTDVKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMQ4</accession>
    <name>A0A232FMQ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000030">
        <property type="protein sequence ID" value="OXU31800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMQ4"/>
    <dbReference type="STRING" id="543379.A0A232FMQ4"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="559" mass="60971" checksum="A1802F2B2E1D1E1F" modified="2017-10-25" version="1">MATSSSNTSSPAMSFPKSPKSPRQLPQLPGQRSPNNQLSARSPSTPRVFEFPPEFSSGGQTAAETPNTNFDFDDFVRAVDAKSPQEFSAPKSPSLYGGSSSAGPKSPSIFGGSCGTPVTCTSKSPGTASPSRAKSPIFQFCNPRRNISKTLSYPPKSPLSPSVSIHSHASNSLKYVSGPKPIERRRNSSLSSPSIVTPPGRTSPKPQDSPELEMRESNSPGNPLGMMQGNAWNRESLKMHTRQGRTTSYLNKSQGCLNEAVKKEVRSGTSVKSERNMSRKSTSDLTELNDADTEVTILSSPRRRGSMKGGLAYLASRRGSRDSQASNLSNVSNEEIGPLNFSAHPRVRQRRTSNFLELPVPDHIRPRVHSLPEKAYNPRAGDDLYRLRAFSITHKGVVNRGDSIISRRSRSNTSVNSSSSKNFLTQDRSTAEASAEGLRECKRRGVARATLEGSILTERSCASGFALSIFAKFSIASPSRDAYPAASSTFFYIRPLAYIPRAWKIRDPEDVGVERKLGITYALRERIAAFLRRNPPAPLIRPIHREEPSASSLQNISQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ECX9</accession>
    <name>A0A232ECX9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01011830">
        <property type="protein sequence ID" value="OXU16218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="261" mass="29150" checksum="F90A06456DC88511" modified="2017-10-25" version="1">MGDDDNGVRVRNGIINLGIANEAGNRNENGGRQDFHGNLIADDGKNFDVPPDDDLNDQEMQDIDELLEDPPNQNLQQIGLPNLNQQRQRNEVGGWRLGDQGVLGAARPNQGQQMPVQNAVGLVRQALVPRLQRGNRNADAVGNPGRQDNRDNRGEQAQADRNQVRHNAGGNQIRQEDKARGGQAQADENQVINNSNRGSRGTRAGQNRRRYTTPRLNPYERDLRNVAQYFVEVALSCTSRTKANLQREREXGKLKQMKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDE0</accession>
    <name>A0A232EDE0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006867">
        <property type="protein sequence ID" value="OXU16355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDE0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="14735" checksum="74922A57F3A5FE1F" modified="2017-10-25" version="1">MMGRIRYACLITKDDPKNRYCKPIDVIYRSKRDKQHIFPSDARDFDKNHTYSVYWRVCKKNCKVEDKCCSFYKAYIISLGESEEDALKAAANRTRRFRFVKKFESSDTNESTVEEFTQQELSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDI8</accession>
    <name>A0A232EDI8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006363">
        <property type="protein sequence ID" value="OXU16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDI8"/>
    <dbReference type="STRING" id="543379.A0A232EDI8"/>
    <dbReference type="OrthoDB" id="7699767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611:SF3">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47611">
        <property type="entry name" value="HAT DIMERISATION DOMAIN, C-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8424" checksum="10A1D2DBC58854F0" modified="2017-10-25" version="1">MNESSIEYWNRNSTSLSTLAKRYMVIMVTSVPSERLFSKAGRIMTQDRSSLSPKHLQHLLFLASLRKKDWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDU6</accession>
    <name>A0A232EDU6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005885">
        <property type="protein sequence ID" value="OXU16527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDU6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7369" checksum="35F2BB1C11800D47" modified="2017-10-25" version="1">MWSNQSWQDSRPLLRGQSATPVAVHQVRKARAREVGQHALPEVAVPLQTSAIPTRWPTMPKVATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE75</accession>
    <name>A0A232EE75_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005493">
        <property type="protein sequence ID" value="OXU16657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE75"/>
    <dbReference type="STRING" id="543379.A0A232EE75"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="203" mass="23646" checksum="6162C4394C9B92FB" modified="2017-10-25" version="1">MSGCEDETRAGEPSVFFRPDGPGESYRLALARLLQSRTGRTLKREISKLTEAELDAELEARHCSLRGSVQLRRERLFRRTIPEAEPSVRNVPWFEWDWERNAYLISEEEMEREYGLEKKAKPPRQTAKQKLPEKPARRESSSENEMAPIGPRIVDVQNQSGRAFLLDSSKPAKLEPRFVPRDFLEITFENLFKRKEIRISNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEB6</accession>
    <name>A0A232EEB6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005394">
        <property type="protein sequence ID" value="OXU16700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEB6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="122" mass="13608" checksum="8939320241159BA6" modified="2017-10-25" version="1">MKGTPVGRTDIPPEKPIPHDDRHGGVGRNITHSIRRTTSGDEPISTGILPRTPDIHCLSNADAQFDHLVIYTRPYVDKVPGPLRDELMRNFASLKILGRNADILIIIRSRATFQIIRNIIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEQ3</accession>
    <name>A0A232EEQ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_005319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005238">
        <property type="protein sequence ID" value="OXU16846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEQ3"/>
    <dbReference type="STRING" id="543379.A0A232EEQ3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF336">
        <property type="entry name" value="LP19554P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU16846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="601" mass="66875" checksum="EB2BA3DC94470FB1" modified="2017-10-25" version="1">MWDKRFFSWAIPTRWLPVRAIICVMMFTACWTSYMCRLQMPILAVPMIAAEVNNSSVSGACVQEHSADVVTPKLAALWRNPDEVLHDIVAGEISRSKRQADDKLNPGQREIGDLMSGRPFDWSPQVRGQLLAAYAYGNVPGNLLGGIMSMRFGPRQTILWTSLVAAIASLLSPILANIHWGALLGTRVLVGLTGGVIFPACHTMVAKWSPPDEKARFVWSLLGGTFGTILTYPMIAGIADHVNWECGWYIPSALMLVWVFFWYLLAYDSPLEHPAITEEEKNFIITSQAGTVRSEKPSLKETPLGQIFSSVPFLSLVVCHFGNLFLLFFYQNSMMLYLTKALGFQLTKGGFLASLPWLGRMVFGFFFSWAGDTVKKRQIISLTAFRKCATIFCKQLYRVNDVQYGATAHFLPGICLIVVGYVGCSFTLANVFLFLALGFNGAASIANLSNNQDLSPNYAGFLYGIMNTIGTTTGMIIPPMVEAIAGKYGTNMRSWHGPILWYLKHSTVVYQEILFADSSEEDTNITALLMYKHFAYYNDILVTNSIRNSLNPIDKWQIVFWIGAAVCIFCMIVFIIGGSAKIQSWNEPRQRDAKNATSANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEX3</accession>
    <name>A0A232EEX3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005210">
        <property type="protein sequence ID" value="OXU16884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEX3"/>
    <dbReference type="OrthoDB" id="7489571at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="115" mass="12897" checksum="A98885755E65F838" modified="2017-10-25" version="1">MSTKENSGEVAVEKVTENDKPNADAKCEIKGIKRAAEEKNDEPKKQKKEENGDGEVEEEECDDEVDNEEEEVEDGEDDEDEEDIPEGEDDLDEEDDEEDAEAEAEGEVDDEEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFF5</accession>
    <name>A0A232EFF5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005041">
        <property type="protein sequence ID" value="OXU17077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFF5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="147" mass="16641" checksum="D4BF607438C2286D" modified="2017-10-25" version="1" fragment="single">SKKIFVYHTNLKITTLLSILRLLCYKILYETVAGGDFLPLLEVFHTSETNNSISNSGLSAKSRIKYCMQHGIKVDFISADYCPREKSTCLGSKPTRGKNMLPSPFTAKIRKSRPFATKVILICTVRLTHERSECDKHGAKKDYSSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFM7</accession>
    <name>A0A232EFM7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_010095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004977">
        <property type="protein sequence ID" value="OXU17147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EFM7"/>
    <dbReference type="OrthoDB" id="6581538at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="169"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="332"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="553"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="691"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU17147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="793" mass="91676" checksum="C414834E2485B57A" modified="2017-10-25" version="1">MKQSKRKRVERKMLAVAAFLLDDDEEDVEMEFQRMHMAWKRTIRDMSDPFTMGDNVFSKHYRMIPAIAIHLIELLRPQLVEYEQGIPVHLQVLLVLRFLAEGSYQKGVAHDCYHPMDQSTFSKYLHEVVPAIVGLADEYIVFPRNMEKRQEMSRRFEESLGFPGVIGAIDCTLPKIHTPHEHEEVYVNHNQDHSLIVQVVSDMDCNILNIRITNGSSNDRFVWRHSQMRETMYXVLRFLAEGSYQKGVAHDCYHPMDQSTFSKYLHEVVPAIKYGGTPRNVKKIGIVENYLFICTIIHTTLHYIPLYSPHYFHFSLNRFEESLGFPGVIGAIDCTLPKIHTPREHEEAYVNHNQDHSLNVQVVYLFFSDMDYNILNIRITNGSSNDRFVWRHSQMRETMYQLRNNPDPAGMNNEYYLIGDGGYTPSPVLLTPCQEAAPGSPEXEQGIPVHLQVLLVLRFLAEGSYQKGVAHDCYHPMDQSTFSKYLHEVVPAIKYGGTPRNVKKIGIVENYLFICTIIHTTLHYIPLYSPHYFHFSLNRFEESLGFPGVIGAIDCTLPKIHTPHEHEEVYVNHNQDHSLIVQVVSDMDCNILNIRITNGSSNDRFVWRHSQMRETMYLRNNPDPAEMNNEYYLIGDGGYTPSPVLLTPCQEAAPGSPEFRYSDRVRRTRCRVEQTFGIWKQVFRCINGDRDGGYTPSPVLLTPCQEAAPGSPEFRYSDRVRRTRCRVEQTFGIWKQVFRCINGDRSLHYTPEFSSQIVLTTAVLYNYLRHQGKAVFIISILKKNISTSKNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFX9</accession>
    <name>A0A232EFX9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004901">
        <property type="protein sequence ID" value="OXU17269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFX9"/>
    <dbReference type="STRING" id="543379.A0A232EFX9"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF4">
        <property type="entry name" value="GH11294P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="44"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU17269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58474" checksum="5BD2C14635053877" modified="2017-10-25" version="1">MKPSTDEEVCAVCKVPAKQKCGGCKSVFYCGREHQKANWREHSAKCKSYKLVENEKLGRHYVAIRRIEAGEVVIREDYALVQAPQQETVPICLGCYKPLKSDTAKPCELCGWPLCASCTSHGAECDFTKRHRDTKVTITGFGIAHPTYKCISVVRALALRETNPEAYDRFTKLASGELEEPREVARFVKRFFDKLDDFSEDEIARAAGIMQINGHEVPISEPVLIAVYDESSYVEHSCRANCSKSFSSSGGIVIRAAMDIEKGEHIAICYTDPLWGAANRRHHLLRTKFFECTCQRCSDPTEFGSMFNAVKCSKSDCSGCMLPKSFTVEEIPDYQCNKCDNSRSSNSIDEMLEQIGKEMASMRKNDAGACRSFTKKYASKLHDNHYYMTDVKLALAQMIGQQTGGLPALDNETISEKILICKKLDDLLKTIVPAENRVRGLVLFEMHAAVAEFARRQDREQLYDILRESKRLLNEAYQLLKYEPELLPEGIIAKTAKKNLREMDMILKQLCRNTVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGE9</accession>
    <name>A0A232EGE9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004785">
        <property type="protein sequence ID" value="OXU17414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGE9"/>
    <dbReference type="STRING" id="543379.A0A232EGE9"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="17832" checksum="B6ABFC6D153E30E7" modified="2017-10-25" version="1">MAKWLGLDKVNNFLQIIKQNGGIWGSLRTLYRMDELKFGDCVGEDKYGNKYYENNMYFVDDNESRFDNSTGRNRWVVYNPKVHLNYDASQVPAEWYGWLHYKTDLLPHKDPHRPKYKWMAEHTPNLSGTDKAYMPYSTTKPKIEAWQPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGF7</accession>
    <name>A0A232EGF7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 11 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_012854</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004774">
        <property type="protein sequence ID" value="OXU17433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGF7"/>
    <dbReference type="STRING" id="543379.A0A232EGF7"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000258">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="13">
        <location>
            <begin position="403"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="13">
        <location>
            <begin position="568"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="812"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1007"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU17433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1077" mass="123224" checksum="BCD99D024748C1BB" modified="2017-10-25" version="1">MAFLEWRRFNFFELKKDVDSGKIAEALGEAHVTAGTSGNGHLVFGDNIGNVHLVNRQYEILTFRAYETSLTAAQQVQNSTFLFTIGVKVFIGNFQEDEPGCNPTIKVWNLAKKDKQGYPTCVRISRAIPSYRAVPASALCVHSSLTLMAVGFEDGSIMLYRGDLTRERKNKIKVLKDSSAVVTGLAIKSTGKQTYLFVATTNNKEFKSALDNMGCARKCSILAESKQDSHFMIGRNDAIYCYTPDGRGPCYAVEGQKIMLEWFRSYLVIITKDTGIVNRTATTVSAKPSTIEPIPPGADKHMITVLDIQNKFIVFSASMLSVQAVLSEWGGFFILSGDSKLYHLDEKDLQSKLALLFKKNLYDVSIRIAKNQHYDTEGLVDIFRQYGDHLYSKGDHNGAIEQYIKTIGKLEPSYIIRKFLDSQHTDYLTTYLQALHKQGQATEDHTTLLLNCYTKLNHTDKLKEFIMTKDREVDFDVEIAIKVCRQGSPEDALLLAQKHGKHEWYLRIQIEDKAEYKKALEYIATLDFEEAEMNMKKYGNILIENVPNEATQFLKILCTNYIPTNKALPEKEPSVEKANPEDFIHLFLNNSERLVEFLEHLIKTDSKWSTPVYNTLVEHYLHVWSSLNEEISKLQYEQKVVRLLQNSNACYDKDQILILCYQHNFRRGVLYLYEERKLYQEILLYHLREGDSEQVLATCNKFGRQDPNLWIHALWSVAWNKNSPPKLLSDILDYIAKEKLLSPLMVIDALSTSLTCTLGDVRGYLNSVLRQEHEQVQSDTELTEKYRADTEKLREQIQTIKNSTIIFQGSRCSACHHQLELPSVHFMCQHSYHQHCFQSFSENENECPACMPDNKKWLDIIRVQEQSKDLHETFHSLLDRAEDPFSLVADYFGRGVFKKLMVITEWQQSQVTKRPVKQEQKSNYNSYGPGAEAKIRLTEGKNTALVKTEQRRNYPFSSQSTSSNLLCAINKQDVYCSSLEANIAGSSFSTPQNSTRKESPVPIREARIINNPTPKSSPAEKAFIPPKTPIVPSNPFIEDYDESKNPFAEDDDDDDKNNPFKDDYDDDYDKNLNRFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH29</accession>
    <name>A0A232EH29_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004601">
        <property type="protein sequence ID" value="OXU17669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH29"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="229" mass="26590" checksum="BDEB5E36936E84C3" modified="2017-10-25" version="1">MRTRKFEGTKRRIEPFHVVKMKEKSILLNIVTRLSDGEATETCELHVEKERRSIVARIAERECWYLLVVGCLEFRYNGLRDIRPVSLYQDVSLADILETAMICSSCRKSYSSINFNSSNNSLNEPSEKENERPQNKRIRLSREAQLEQMLDGLKSKLSSLPPNDPLIVSLLTIAPECWRLRDIESEFNVSLRNAKKARDWKDEIFENFRTICLKAYGLDPAHYYTAPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHA8</accession>
    <name>A0A232EHA8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004545">
        <property type="protein sequence ID" value="OXU17724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHA8"/>
    <dbReference type="STRING" id="543379.A0A232EHA8"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF110">
        <property type="entry name" value="LD43683P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393948" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="285"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="491"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="693"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="846"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="905"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="799"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="914"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU17724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1273" mass="134752" checksum="2EF9BB6163C64078" modified="2017-10-25" version="1">MLKSLHLLCVLGTVTHLRPVQSGGFYNDYDNEVYDYYRQESSNQDNVQQPAGGVNYACKEEGFHEDPNDCRTFYRCVDWGNGSPLTPFKFECGEGTVFSKSKGNVCVHPNSSGRPECCEPGNEIDSNEPGTGGDGWDQQPQRPEKPSYPPQQTQRPSYPSQQTQRPTYPTQQTQRPSYPTQQPGYPPQQTQRPSYPSEQTQRPAYPTQQTQRPTYPTQQTQRPSYPTQQPGYPPQQTQRPQQPTYPPQQTQRPEQPSTPSNPQRPEKPSTGCGQGGGSEGSCGSSPGCSEEGFFANPEDCHKFYRCVDEDGRLQRHDFTCGSGTAWDQGLQTCNHEHEVPSCGGAGPGSEPGQGTTSGPWTTQSGQQTSRQPGSGGSQTQRPTQPPYIPPSTKQTYPPPSQGTLSPTQRPYPTQPTTQSSQSTKGPEYIPPQRPSTSGPPSGGDGGVTQAPGGAGSTQAPGGGGATQGPGTGGETQAPGTGGKPCPPTGSASDCTGEGFFPNPEDCHKFYRCVNEDGTFRKYDFECGTGTAWDQQLQTCNYEDAVGCGSGGSPGGQQPGGQQPGGQEPGTGSSPGGQQPGSGTGPGGEQPGATPSTTTTVSSQPTGTTPTFTTQSPQTTPQVTQPATEATKQPEAPSTAAPTQPTTQQQQTPQQPTQQPPTQGPPTQSTPQQPPQSTSSPGTGGPGPQQPGSSGACQSEGFFANPNDCRKFYRCVSNPPGFIKYDFDCGPGTAWDQSLLTCNHIHLVASCNEIEPNQPPTSGSGSTPGPSGPSSTQSPPGTQPPPEENKTEPSKPTQMTTTSGESSSEGSSTTATSTEGSSSPSSSTEGSSEGSKPDCNPPKKNNTIVCNTAGFYPHPSRCDKFYRCVDNGKGFNVYYFDCPPGTIFDPSIDVCNYPESVYPARDCDNAGDSQGGAPSQPPASSTTQPSTSSEGTTAAPSATTPSTEGTTETSSEGTTETPGQESTTPGSTEATTISSEATTISSEGTTSSSEGTTTSPEATTTPGGTEATTTSSETEPTTTASSTSMETTTTAATEATTTPPESTSPEEQQSTPSTMPQETTTEPSQESTTPAGEKPPSVDNCPTLANLTDEQIVLVCPTGFKRHPKLCNLFYQCTTAGMEVKILILQCPEGTIFDEKDNKCLAESESSMPCTGSIAGKRTQRRAANDSPALVEVSTKPLCPEEGHFPYRDGCSNVFYKCKRDSRYALQGYLYKCPKDFVYWSVSRRCERASRLPMCTSMSNETENENEAWENRWEIPVEDRNVSARSILFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI28</accession>
    <name>A0A232EI28_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004360">
        <property type="protein sequence ID" value="OXU18003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI28"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="57" mass="6688" checksum="54414B0FEF16DD49" modified="2017-10-25" version="1" fragment="single">IKWRGSATKASLRSRRSRGALDTIYFYIGVRIFHYTKKKYLSLLLVRFLGSLECFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ49</accession>
    <name>A0A232EJ49_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004090">
        <property type="protein sequence ID" value="OXU18386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ49"/>
    <dbReference type="STRING" id="543379.A0A232EJ49"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF72">
        <property type="entry name" value="GAMMA-GLUTAMYL TRANSPEPTIDASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="433"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="485"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66205" checksum="7F47F456D6653489" modified="2017-10-25" version="1">MLKDYRYYTPLVQVKTHRNKYSNRPVRKKTCLIGGSVIVVLALIVIISLVVVLKPGSDLRRDNRYVSESPLGIYKKAAVSSNGPECAQIGADMLERGGSAVDGAIATLLCEGISSLHSMGLGGGFFMTIYDAETGTVNFLDARETAPAAAHKDMFNGNSSLSLYGGKAVAVPGELLGYWEAHRKYGKLNWTDLFEPSIALAEKGCLVNRYLENSLKGKEAFIRKEPTLAEILINEETGELYTTGQRIKRPKLAQTLRKLANSPAPHDLFYRGDIARDLVAELESFDAIITGEDFENYAVKWKKPLESRIGNMTMYTAPPPGSGALLTFMMNVLEDLVPANDTRVTWQRVIEAFKWAYAKRTELGDPDKEDVEAIVANLTSKDYAYAIRSLIEDTKTHNDPKYYGAVTTNQREHGTSHTCVLAPDGSAVSVTSTINQVLGAKIRSSSTGIIFNDEMDDFSSPNITNGFDLPPSPANFIKPGKRPLSSMSPTIVLDANRRVRLVIGAAGGSKITTAVAAIMILNLWNDYDIKEAIDAYRIHHQLFPMQVQIEHDFPPYVLDYLREIGHSITTYAGIGSAVTAISDNNGRITANSDFRRQGTTAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK13</accession>
    <name>A0A232EK13_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003893">
        <property type="protein sequence ID" value="OXU18704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK13"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="241" mass="27126" checksum="D89DDE26D41FE7E3" modified="2017-10-25" version="1">MSAGSQGCLVARLAKRKTVAHAGQQGICLVTLRRINCLVDIFSLREYLEYALFGVQLCPTRWTNVYNLENQPMISMNSKIVTNLSITLYPDVQYSSNRLSSDNSHRIQSQEPKTKHQRFKLMKELTGSLANLGSMVTKERFRQRADLITTIIDAWSQDKDIELDQLIVTSLSNLSIYEKNTLDEDEVIDLSSITMPTPLEIRGTPKNVFKNILAKVIVAGTTVLTNASQVQKMSCIEILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK92</accession>
    <name>A0A232EK92_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">28S ribosomal protein S18c, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003850">
        <property type="protein sequence ID" value="OXU18765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK92"/>
    <dbReference type="STRING" id="543379.A0A232EK92"/>
    <dbReference type="OrthoDB" id="10066799at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000018">
        <property type="entry name" value="28S ribosomal protein S18C, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17479" checksum="ECAF7235D9D55DDD" modified="2017-10-25" version="1">MKILTYSRVLSDQVFSLLRNLSNSGRVSVYASQQRAQHSSAEETDAVRTPIELENPYQRERKMCILCKHNIDPDYKNVRLLSQFQSRFTGRIYGRHITGLCKYKQERVENEITKAQHAGLMPFYYKEITYVNDPKLFDVNNPFRPHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKF8</accession>
    <name>A0A232EKF8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_013279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003821">
        <property type="protein sequence ID" value="OXU18801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKF8"/>
    <dbReference type="STRING" id="543379.A0A232EKF8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35339" checksum="FB2C54D4CDA9E225" modified="2017-10-25" version="1">MPAVIIRYSGKGWPAVFYFFGALGMIWFPFWVLLTFNEPEQHPYISEAELNYLQENQAERQKKKKAPPAPWGHILASKQFWAFVMALAGCDWAYFTMASDLPKYMSNVVKFSIEDNGYLSALPYLCMWFSTLISSWLSNKILERGLISRTNVLKLLASISLMGPGLFMIGASYAECDQLMVVVMFIIGMSLMGTSYPSIMVNNLDLSPNYAGTLMAIGNSVAALGGIMTPYIVGVFTPEQTIHEWRRVFWIVLIINVLSNIFFLFYASGEVQEWDSPDFLRSKNKAAAKEVSGDEAITEKPKSIITVDLESARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKP7</accession>
    <name>A0A232EKP7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003762">
        <property type="protein sequence ID" value="OXU18888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKP7"/>
    <dbReference type="STRING" id="543379.A0A232EKP7"/>
    <dbReference type="OrthoDB" id="10013535at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022179">
        <property type="entry name" value="CFAP276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12494">
        <property type="entry name" value="DUF3695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="191" mass="22068" checksum="539BCC0CD3CCDF39" modified="2017-10-25" version="1">MDGEMTKSVRNPYPVPELSREGRWYAGGPVLGENVCADERRWYSKLEPHERLFSHQTLTSARRDCRYRSVEVPRDSLDLMLSSVYIHDRDLFLPKMYVMMQPETVNRETWRVLRNEIKVYSKSPVPLGHEIKYADIEPKGCAESSRAAVGLKDRVRNKIHPSSLQLAIEGPHTDRTNPGYSRKIDGTYYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKS0</accession>
    <name>A0A232EKS0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 50A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_000016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003720">
        <property type="protein sequence ID" value="OXU18959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKS0"/>
    <dbReference type="STRING" id="543379.A0A232EKS0"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17367" checksum="3E3490B41DEE17E7" modified="2017-10-25" version="1">MASCLENIQIPSCVWFESGEKRNALASMLAGTFFFLGWWFIIDAHAKYPLEMSNAYHVCGIFGTMSLLMVNSVTNAQIRGDAYNGGCLGPRGARGWLFIGLVMGFAAVIAACWILFADFVAADVQHHWPGVGLFLQNVFIFLGSLTYKFGRSEDHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKY8</accession>
    <name>A0A232EKY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003673">
        <property type="protein sequence ID" value="OXU19020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKY8"/>
    <dbReference type="STRING" id="543379.A0A232EKY8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000223">
        <property type="entry name" value="Goosecoid homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF516">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU19020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="216" mass="23736" checksum="FB987E1A15368FBE" modified="2017-10-25" version="1">MQGGTEGSNARNAAAAAAAAAGVHPLQQQLHHLAFTSADFLAAAYPGLYPGGYVAAMAAAGVSLHGQPAFYHGAHPYQLSPSGGPGVGPMAKRKRRHRTIFTEEQLEQLEATFDKTHYPDVLLREQLALQVDLKEERIEVWFKNRRAKWRKQKREEQERLRKLQIEQRSRGGSGANDAVSVSPLRVSAAHLAASRQQQQQQHCTDHDTDSSDLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELD6</accession>
    <name>A0A232ELD6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003571">
        <property type="protein sequence ID" value="OXU19173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELD6"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="307" mass="33368" checksum="790598956AA25549" modified="2017-10-25" version="1">MSYTKFVLPCYGCQQQVTYIAFITSPLTLPCRPGALLPVQSGWWCRLLVVSDASDALERVLGWPWRAASAQDHTQPAAPEELGVPSSSCTKLALRIADWGRGSEQAGSQASSSIDRSAAGVGHSAPVASNATSGGLLGENREKEAAEAFAIHCERVRSLLDFVLPRNNVHKEIKAMARAASKTLGEYSKLLRLGPAVTTPLGRRKDGGCQTSPIFRPNVPQNTGEHEPPPPPLPPAAKKRKADGDMHDQSKVPDWATVVKKGKEKKKKTKGSQPQQQQQQQRGASKPADQSEIRPSRCYLYNKFPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM22</accession>
    <name>A0A232EM22_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_017050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003441">
        <property type="protein sequence ID" value="OXU19413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM22"/>
    <dbReference type="STRING" id="543379.A0A232EM22"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="122"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="293"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="444" mass="49762" checksum="5EB8165930D24A42" modified="2017-10-25" version="1">MPRSESTSEFQPLEDKEVEYFFASDASAVIEHTNRVIFLEDDDVAAVKDGALSIHRLRRCVDDAHAREIHTLKMQIQQIMKGNYEYFMQKEIFEQPESVVNTMRGRLNFRDNSVTLGGIKDYIPEIKRCRRLMLIGCGTSYHSAVATRQLLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMALRYCKGRGALIVGITNTVGSSICRESHCGVHINAGPEIGVASTKAYTSQFISLVMFALVMSEDRISLGQRRMEIIEGLKNLDNQIREVLKLDDEVKELAKSLFQHKSLLIMGRGYNFATCMEGALKVKELTYMHSEGIMAGELKHGPLALVDDSMPVIMIVMRDPVYVKCMNALQQVTARDGRPIVICEEGDDETKSFAAKCLEIPKTVDCLQGILTVIPMQLLSFHIAVLRGCNVDCPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMT2</accession>
    <name>A0A232EMT2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003301">
        <property type="protein sequence ID" value="OXU19656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMT2"/>
    <dbReference type="STRING" id="543379.A0A232EMT2"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011816209" description="Calnexin" evidence="10">
        <location>
            <begin position="26"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="65632" checksum="F3F1AFD3571CA5D3" modified="2017-10-25" version="1">MALTRRQVLCLLLLAVCGRFVPSRAAEPEVEDVVIEDEPADNEPKIEDYKSPELPGNVYLADHFDDKQGFDKIWIQSQAKKENIDEDIAKYDGIWAVEEPKRSVENGNLGLVLKSKARHAALSALLNKPFIFDDKPLIVQYEVIFQEGQECGGAYLKLISVDPQHKDLRNFHDKTPYSIMFGPDKCGNDHMLHFIFRHRNPLNGSIEEKHAKKPKERLEDFFKDKQPHLYTLVVRPDNTFEVKVDGNVVNEGSLLDDFTPPVNPPLEIEDPNDKRPEDWDEREKIPDPTAVKPEDWDEDAPAQIVDENDQVPEGWLEDEPPTIPNPDSVKPADWDEEMDGEWEPPEIQNPKCLDAPGCGPYKKRLISNPKYKGKWLPPLINNPNYQGKWKPRLIHNPDYFNDENPFRMTPIYAVGFELWSMSPDILFDNIIVTDDEIVAQKWAEQTFEVRKQRIAIESSGLYQQVVNFTVEHPWIWTVYLILLGIPIMLIIYCCCFTSKDSQDKEDDTENENEELLQKDKEESEAATVEEVNDDKVEESPESEEQAEEIIKSKESISTAEGPRRRKANKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN15</accession>
    <name>A0A232EN15_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003267">
        <property type="protein sequence ID" value="OXU19712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN15"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11622" checksum="5A573AC0187DA6F9" modified="2017-10-25" version="1">MASVLILPNSEKEQWSILQYFQLEEKIRQQVKLQEKMLELTLDKDFRKQLQPVKQRLAADIREVIPLGNPRQHLRRKMTKLIPEPTSRAIFTEKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPF4</accession>
    <name>A0A232EPF4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002956">
        <property type="protein sequence ID" value="OXU20218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPF4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="71" mass="7978" checksum="6D2FA7685243ACD6" modified="2017-10-25" version="1">MSLGLGTKTLYGPSLHINIPNVAEILKIVDDLQEITFWRVTERRLPVSSSMRSYGRLRQPCGDAQVLSVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPI8</accession>
    <name>A0A232EPI8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002931">
        <property type="protein sequence ID" value="OXU20275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPI8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8488" checksum="F0E0AD1342FDAC29" modified="2017-10-25" version="1" fragment="single">DPGVTFSHKLSPRTDALLIKRRRKLGPAKTKTLSRGLPKGLEAVRALLYIYSYTHAVMCIRERLPPIDSLAWQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPM9</accession>
    <name>A0A232EPM9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002920">
        <property type="protein sequence ID" value="OXU20303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPM9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="48" mass="5676" checksum="A8EBDF99352175DB" modified="2017-10-25" version="1">MYVHISTYIHKALAYSVTKLAPEQTEKVFWRRCVQAIFSSRYTGHQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPN2</accession>
    <name>A0A232EPN2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002916">
        <property type="protein sequence ID" value="OXU20320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPN2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="164" mass="18146" checksum="A94672C844247A5F" modified="2017-10-25" version="1" fragment="single">MTGILKSLGHGTNQAALQIYSSVSLFFNYSELKNKYLVPGNVVSNYCASLESKSRLKTQKINNSVTYKRKIKTKSNVVKYLKDGVFHVGEILTYYILIELDVPIGLSWTSVLKKRKSGRLPDFGSKNGSLGNCQTSEVSLGNCQTLKVKKCKSGQKSGKYPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ70</accession>
    <name>A0A232EQ70_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002821">
        <property type="protein sequence ID" value="OXU20491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ70"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="167" mass="19227" checksum="2F3978AEB0393120" modified="2017-10-25" version="1">MVQLNKKTCEFNMEVVGEMMKNSKTTVSKGRKKGKSISEGQKARNQLFDFLRKQATGKHNLTAGLDDEFHAVRRPLTYKLRRKHYKNCCNQSDILRRPKNLGSRLIGKRSTVITNNLQKVLLPLRDDAITDAIMNDDLILEYENSYAYKHRHSPHLGAMTPTNRTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQC8</accession>
    <name>A0A232EQC8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002769">
        <property type="protein sequence ID" value="OXU20599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQC8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25095" checksum="29BDC119E13537F9" modified="2017-10-25" version="1">MSPSKQLTKYCKKTDNYSTRRRHRASTLKFKRQRLFLKKQKSVLRHKNEISEGATYESNISLVDNVNDSIEIACIDENYESIVVFFDLETSSTNGDCDILQIAVKYEAYEFSIYIKPTQLISDKASQINGLTFTNGNLKLHEIIVITVNLQEALAKNSNIQGFEAHDAAGDVAILEQILLKLNITKTQILQCSFAWNEAKEKILVSKKCTSNLKFVMLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQQ3</accession>
    <name>A0A232EQQ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002713">
        <property type="protein sequence ID" value="OXU20719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQQ3"/>
    <dbReference type="OrthoDB" id="7549643at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9956" checksum="468620DDD6C12927" modified="2017-10-25" version="1">MKTSNPPGIVMQHPTFEGLRLHSSLVDQRLDALKTLVGKVNRTYDYVLEYLKTALEAEEPQNIKNILIEFKEFEQFYSRHDIALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQV5</accession>
    <name>A0A232EQV5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_002401</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002731">
        <property type="protein sequence ID" value="OXU20676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQV5"/>
    <dbReference type="STRING" id="543379.A0A232EQV5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280159" description="Cytochrome P450" evidence="16">
        <location>
            <begin position="20"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU20676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="59212" checksum="40E3039E8E127E6E" modified="2017-10-25" version="1">MTIYFLLILLGLWVFKVYFQNKRSKELLDKIPGPPTVPILGNLLMFNVPIEKTWNVIRDLNKNYYPIAKFWLGPYPYVSIHHPDDLEILLSSTKHLEKGSAYTVLHPWLRTGLLTSSGSKWQQRRKILTPAFHFKILKKYMEITNEHGKKFIEALRTENSETVQSLMPFCSNYTLHIICESAMGIALDKIDTKISKEYKNAVADIANLIMYRVMRPYLKEWMMLPVWTFGRLQTQTLRTLHKFTKTVLTERREYHKRSDNKYLKGFHDDTYDVNKDDVAIGGKKKLAMLDLLLSAAQDGLLDDEGIKEEVDTFMFAGHDTTGIALVYAIMLLAEHKEIQEKARAEVIEVLTESNGEIGTLEIQKLHYLERCIKESLRIFPPASALSRTVKEDIKLKNYVVPAGTEIGCHIFDLHRDPNFWPEPEKYDPDRFLPENIQGRHPYAYIPFSAGSRNCIGQKFAMMELKSLAARILYNFELEPVSQTKDMKLTLDLVTRPLEPVYTKFIRIDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER99</accession>
    <name>A0A232ER99_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002660">
        <property type="protein sequence ID" value="OXU20847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER99"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10398" checksum="BE69EB8A4104FE81" modified="2017-10-25" version="1">MVLTRLTVNCTVFDLLTGDSWKIAQLMLDLTEFSMYAENVLKAFEQAEKCYHLILEQEDLISSEREYSAPYAQQKEIKYDKKSLLVKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERL1</accession>
    <name>A0A232ERL1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_005657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ITM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002581">
        <property type="protein sequence ID" value="OXU20998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERL1"/>
    <dbReference type="STRING" id="543379.A0A232ERL1"/>
    <dbReference type="OrthoDB" id="9982095at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042985">
        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040145">
        <property type="entry name" value="ITM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962">
        <property type="entry name" value="INTEGRAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="10">
        <location>
            <begin position="158"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="298" mass="34049" checksum="998D21B4DE44B49D" modified="2017-10-25" version="1">MTVITKAIGEKKVKAGDKLEQPLVVGLEVPTDEAQVDPESQHPKNDYVVRKRYLILSSNALRPSAMTTLCLFMTAIIVMSIGIIGGLCIYKLYARDQMHRFRTAWYSIPYDASNKAQYSMDEQLAMEFEKAIRPKNFFSEQFEIDVDNQIQKIDVPDFRGGRQGRFIHDFNINKTGIIDIDGHSCFVMPLNRQRVLPPRNMYDLLKKMYNGKVSSYYEVDTDIVRETMKVLVPPIDDLSVIGTYIARECQSMPTYLLQPVNDNVYKRSTSSGIYGQFAGKNIIEFDIINLDSVITKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERT5</accession>
    <name>A0A232ERT5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_011379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002553">
        <property type="protein sequence ID" value="OXU21069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERT5"/>
    <dbReference type="STRING" id="543379.A0A232ERT5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="418" mass="46094" checksum="AD4829D96E2337E1" modified="2017-10-25" version="1">MKEELTEYHLSMSGGQSGAMSLANPSAIHLGQILAPGSNETISIVIPLSAQLATLSRNAAVQQQQQQQVVCKQEPVDHADKKAPSPKRPKTNPPRIKEDKTKGCPYPNCSRYGRAFSRAHDLKRHIARHESRENKTEAPHQQIHPCLICGAHFYNEQILQRHKAIHENGANSITSTSGPPYTCNFCKKTFEHESLLNAHLPTHIKSEPFLSFQHSTGIPLTSRYQPPNGPPATLPPPPSGIVMPGASASSLGSSDDDYRLEDMLLLRKNAPNPHKTPNHLGSGASASSSSSSSPSSSATSKIRCEYCSKTFKTKWTLSSHVAAHEGRFQYQCCICNKRFVRKSHYESHVRSHDAARPYVCEHCESKHRREHLKRKHPSNRNAIQSLLDSISACVNEEAAAAAAEQAKLTILMPMNFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES18</accession>
    <name>A0A232ES18_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_008037</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01002528">
        <property type="protein sequence ID" value="OXU21132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES18"/>
    <dbReference type="STRING" id="543379.A0A232ES18"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU21132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="358" mass="40687" checksum="14327A19DF05C23C" modified="2017-10-25" version="1">MRLFGLEFAPLLVPWERRLQTLAAAVWFVITAFGGLACWFITFAVLLFGSQWLRLLVIAYLLFAYYDRETSRKGGRSKRIYLLFRNLAWWRYFCAYFPIKIVKTVDLDPTRNYLFCSFPHGILSTGVSGAFTTNGLDCAKLFPGLDFRLLTLDAHFQTPLFREYVLNYGICSCDKDSIDYLLSHKPTERDGPTEAPVTGRACILIVGGAAEAFKCKPQTYNILLKRRKGFVKRALKNGAPLVPVFSFGETDLYDQLNSPEGSFLRAVQEFVKKLTGIAPVVPIGRGLFQYSFGLVPNRKPVHVVVGAPLDVPKIEEPSREEVDLYHAQFTEKLIELFETHKSKYLENHESVKLILDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET00</accession>
    <name>A0A232ET00_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002354">
        <property type="protein sequence ID" value="OXU21483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET00"/>
    <dbReference type="STRING" id="543379.A0A232ET00"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU21483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="432" mass="48829" checksum="EC8B0145D42C6065" modified="2017-10-25" version="1">MLRYLCMRKFEKSYLLAAPWLKTRSNDANKSTANSLAIHSTNLGVSLHKAVKDDDYETADVLLQEKCESDKLFEDDMSLLHTAIKNKSYKMVQLLLKHGSMVNPSRKTPESKTPLFLAVEVNSIEITLLLLSNGALINEARTQSCTVFDLAKKKGNAPLLGLLQVFVKKEVSLEEYKIRKGPAETKKEETKNENTKKKKKQMNDSLLIYVLKKNTLHMAETYRLRYPFWNEAVDSITTSVEHLNLDVKVSKEVFSMSLQEAVKNNNVKITEKLLKKKADVNKRDERKLMPLHVAVINKSHEMVEMLLQNGALVNPSRESPESKAPLYLAVEQNSIEIARLLLNNGALVKKATTATYTALKLAQKNRNKALWKLLAKFAMKQVGANCRVKKRSKRKVETKKSNSLLVSVLNKNTKTTAEKYGLLKEAPIPGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETM3</accession>
    <name>A0A232ETM3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002270">
        <property type="protein sequence ID" value="OXU21667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETM3"/>
    <dbReference type="STRING" id="543379.A0A232ETM3"/>
    <dbReference type="OrthoDB" id="10010359at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF220">
        <property type="entry name" value="LACHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218118" description="Ig-like domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="130"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="222"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU21667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="361" mass="40270" checksum="B3294664B7B86BD9" modified="2017-10-25" version="1">MKLLGVIFVLGLMHSVYSQRTPTISYISQEQIKDIGGTVEFVCSVQYSQDYPVLWIKVNKNREDQLPISTNTALIIRDSRFAIRSDPSSSTYTLQIKDIQETDAGFYLCQILISTSSKISAEVELQVRRPPIISDNSTRSLVVSEGQPVELNCYAGGFPTPRISWRRENNAILPTGGSIYRGNTLKIAHVRKEDRGTYYCVAENGVGRGARRNINLEIEFAPVITAPRPRLGQALQYDMDLECHVEAYPPPGITWHKDEVQLSNNQHYSISHFATADEYTDTTLRVITIEKKQYGEYVCKAANKLGTAETRVELFETIIPVCPPACGQAYYAASIIPLSSGVMVAVALIVATIMRSRSSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU47</accession>
    <name>A0A232EU47_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002167">
        <property type="protein sequence ID" value="OXU21889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU47"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="158" mass="18560" checksum="FC83157C970CB2CC" modified="2017-10-25" version="1" fragment="single">PLYDGCDLTRAESELLILSLSLRHSFTNDALDDVLKTIDCHLPHNEYKSSYRFLKSFSKPEHKECYYCPDCPANLNFETNINRAECEFCHNIYLKKQLYDEGTFFYHLPLESQLTELMQSPLYLNIRRECEESDVINGEIYKDMSKRGIISKNDITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVG8</accession>
    <name>A0A232EVG8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002001">
        <property type="protein sequence ID" value="OXU22344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVG8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="15494" checksum="F9098261501B88B7" modified="2017-10-25" version="1">MLYRNSNPEVRKQAGQCKGRLLCDWRIVSCELRQRNRRHRGPQPPNQVETGLAKALKELKKIEKKGSRALSKRKVFVHTNEQLEEFGKIQAVQVIKERKEEKEYIINLEKKVDEVIGDCQSTPRSIEDIAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVI0</accession>
    <name>A0A232EVI0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001989">
        <property type="protein sequence ID" value="OXU22369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="730"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU22369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1369" mass="159014" checksum="8E6965EF40E954DD" modified="2017-10-25" version="1">MYNILLTADSVQDDDRRRRLPGTEKKTHTHFGPHLVSLGDDNSPQGYYYDFKTFLTLQINMKDGKMRKTGRMLTTQFRTINAMTYSQEMKRGDRSQSVSRVALTCSLYCTSAKINRRFVESIDDIGDIRRTKCTDDTIVSKINKTVKPCESMYSYMCNGEENYQKTEYPNNVLLKIQTHAMNILSSPVESSEPKFFNVDKELYQQCIKLGMYVDLCWRKLRANELAAVFSNVTVKYEQAVIGKAKSIWRLKIYDVSLVLTTLQLQPPSLKHMQTVTNKMIPIMKRKYNYEKVKYFGEFSAFDDLFDFVKEYLKEPVQVFLDSLCRIESTVLQKYREKRLLNIKTTIGDFDNFFEQLSEINEFAKIDWATIIRRTFQKVDIQVTDKEKLSKLLNKTPNNVIVSAVLAKLITENLVYIDWNLSQTLETVNKQSFCLKETKLYGVSHKILYKYIADRSDILLLRRVEDIVANIAEAFVDEILKTYTLFSRERIYLERKLKSITDDLLDHGIIETPQTKNVTKSISRSSLCLGIYHYDIPDWFAYPEYSEDTMSCYESIGIIDFNRHQVMYMITETLGLQIAYQAMLKDNHIKSHNPFSINLLSNNKITMGQLFFSAYVKDHCYANNSMVNKILLNSGYFSNVFNCYNYKILKKCPLQAFDMHLDIRKFGVVRKVNIFGAACLAIYVVSAFAVPIENSLNNIDAVWISNEIHSQNKQNNGLLSVLSGLDKAVDPCEDAYSYACKNGEKIWTQEYLQKIYPEVRNSLIKILSQKPTKKEVHSLSIEKQLFQQCMNLGANETSEAKDEKEVLIARLFEHVFRPNANWKNIDEALNIIGFGHPFFDINVERDPENPSHNIVSLRPPSHAHIKHIKHLITKAFETSKKSNLITNVVDSISTESKNTILNFLSILHPLVFFTTTQTGDAEKIKLNNLNSIGNNDEFAINLRQKIESDRVSEHFPEFKDFLKSQDSNDKSNNSVKSENLENNIEGALRIRNHWYIKIRYIFILTQLSSYLGGFDRHVEVIKFKVLIENLRYIEWKSANSLEHIKRSIFCFGDTKLYGASFKLNRDLRKDTHKEGQYYELVQNMLHEIVDVINTEISNSKIIFPAEKAYFVSEMKLITANALHQNREYVSEYYRYNGQDFEFGSSYFSNIIRYRKLLQRIEMSKLKDTSKSPRPEPYSITDLDRPSNRLFVNSHYSPLSPELPKEIHYSVYGVKIASFLFGLFNEQKRVDALQARHRDDWSAHPTYSKAAIDCFTSSLEQYDKELPKETLTELFGLRIAYKAMLKDYLNEGSRKYFVPELAREGLTADQMFFASYARYHCYYGKRMMNTILSNVDAFSFANNCYEKTANDLPKCHLKGFEIQENNLLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVW1</accession>
    <name>A0A232EVW1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001940">
        <property type="protein sequence ID" value="OXU22498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7701337at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="43689" checksum="77BE280E01F5342F" modified="2017-10-25" version="1">MTIWSVYNTGNGEKIWKKLDEEKFTEEGDLIIGGDFNIQADEKEVLSRSEEDIAEFKEKTSNIEGEIKNEDSAQYTWEEIKKVIKDSVKKKIKIKKWKLGMRKAKSCAREKRAANRALKQWKKGFIPKEKYIRKRREWQEHCREKEKRYKELEEAELRSIKNENDKLSNEFEWSLIPAKKDHRRGRAKGGLIIDVRKNLVIEKSNGEKIWKKLDEEKFTEEGDLIIGGYFNIQADEKEVLSWSEEDIAEFKEKTSNIEGEIKNEDSAQYTWEEIKKVMKDSVKKKIKIKKWKLGMRKAKSCAREKRAANRALKQWKKGFIPKEKYIRKRREWQEHCREKEKRYKELEEAELRSIKNENDVXVHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWB7</accession>
    <name>A0A232EWB7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001893">
        <property type="protein sequence ID" value="OXU22626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="970" mass="109536" checksum="B1E5C4A43AC96CFE" modified="2017-10-25" version="1">MSINNELNISLRLQSLVKDDKLKYYSAPIETIFYKKNDQSPIVAKDLLDFDKTHKYYVLWSKGKNEVPISGQRDDESEFYAAYIVCLGETEDDARLRAISKSKRLIVPKKLTSSESNESLFESQELKPKTGKIIKNVVQKVNSQRTIEKYKQITLMNNRKPLFLGTSTNEYLTENNARNETKTMNLPEVRVVLQDICKTNRDELNHKKNVTIRKMVKCVSLPIAFSTPKRTVEKCSLSLNFQSHKPYERWTPQAEFTKSQQVNIHQNSLSLERDDNVSVSIPQFSPILNGSHLSQSQTPRRLRDKTPFRLQTLLTSTINGPGDHHSPSVGVSKMRCNRLSTLQKIPRLDSPLPSVKRASQHSLSNASLNLDYIDQSDHSDLRMPSRSGRGRLPSIASDSSSRYKDISGPKSQSSTPFVPSSRLYSPVMSSPQEPSTPTRSCSEARSVRCSLSNSLSRSVAEFRTEQETPPRRTGPRSGAQEVVPTXFTKSQQVNIHQNSLSLERDDNVSVSIPQFSPILNGSHLSQSQTPRRLRDKTPFRLQTLLTSTVNGPGDHHSPSVGVSKMGCNRLSTLQKIPRLDSPLPSDKRASQHSLSNASVNLDYIDQSDHSDLRMPSRSRRGRLPSIASDSSSRYKDISGPKSQSSTPFVPSNRLYSPVMSSPQEPSTPTRLCSEARSVRRSLSNSLSRSVAEFRTEQETPPRRTGPRSGAQEVVPTGTPPRRPGPRSVTQKVVPTRTPPRRPGPRSLTRVVVPTRTPPRRPGPRSQTQEVVPTRTPPRRPGSASPGREDIQDNEDENENLEVSAGGESDSAVPMLEQYKPKLFKKYNKAGYDLDSNIPEQHKRYDIVRNKIYLGEGRTIGQKSWRIIKSKRKNAFLRDLGTILWTKKKSWRIIKSKRKNAFLRDLGTILWPKKVIALRSLDLSLYSDFLDTSNRYKQLPQETKDILIKDATESLSFHSRDERKHQDEPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWZ1</accession>
    <name>A0A232EWZ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001810">
        <property type="protein sequence ID" value="OXU22860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWZ1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF48">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33754" checksum="0CE05C6DE7DF0610" modified="2017-10-25" version="1">MATCNNNQYLDREEVAIIIKEAFGTATKFVKYYSTNLSDKKVGFMGSLQTLVVVVEENDCEQKTYSFFFKSIPYEIENQLSWILESKIFTKETNFFKFIVPELMASINDKSWIARCYFIKDDLMVFEDLKIKKFEISTKILDEPCVRYVPPMFEIAQFMHITTGREFRKQRETEMLKHYHDVLCKTLKDNSDRQAPVPSFSDILDQYEEMKIVGIISAALYNPTILVNEDVMTEKVKSSDGYAEFMFSSDRVKFMLEYMEKDTIFKDRLVECITELIERSNILLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZA3</accession>
    <name>A0A232EZA3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001518">
        <property type="protein sequence ID" value="OXU23711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZA3"/>
    <dbReference type="STRING" id="543379.A0A232EZA3"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF102">
        <property type="entry name" value="PIPSQUEAK, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="18435" checksum="CD3A97E85D0D2BAF" modified="2017-10-25" version="1">MAGQHYCLRWNNYQSNMTSVFHQLLQTEAFVDVTLACNEASLKAHKVVLSACSSYFQKLLLSNPCKHPTIIMPQDVCFNDLKFIIEFVYRGEIDVSQAELQQRPFDASKFKLALLSLRSHVGNTTPKLTDTGYTTPYHNSQAVLLYHRRPLNPAVGKAEPVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F126</accession>
    <name>A0A232F126_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_015713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001402">
        <property type="protein sequence ID" value="OXU24098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F126"/>
    <dbReference type="SMR" id="A0A232F126"/>
    <dbReference type="STRING" id="543379.A0A232F126"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="140" mass="16206" checksum="2A33993FF6295C63" modified="2017-10-25" version="1">MTTQRALPQSKEALLKSYTTRLKDDVKSMLENFEEILKLAKGENDTQLSRMTQCEQDTYEMHVRAANMVRAGESLMKLVSDIKQYLILNDFPSVNEAITQNSKLFRAKQAECDQKLASLRDDMAADLYDLEEEYYCSIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F175</accession>
    <name>A0A232F175_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001389">
        <property type="protein sequence ID" value="OXU24148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F175"/>
    <dbReference type="STRING" id="543379.A0A232F175"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="3">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="298" mass="34441" checksum="5F7C8D3AA38E2D53" modified="2017-10-25" version="1">MDWVIHHKGEPPFYHEVSDIREWDKNFLEAGVGEVLSTLPASLISARSRLGTITRHNTDNTSVVSVTYQRNYSSVLSKLHTSCKDRRGLKMYVYALSRVQLVSKDGVRFTVDCEIVKKCMKTVKNLFDNLGKFEPEEAIPILVVNGKILKKVMDWVIHHKGEPPSYQEVSDIREWDKNFLEFDDETLSDIIEAANYLEMGDLLQLCYTHLSTLHARYILRLGYTNLAPLRAWYTPTLPSVVALQLFKPLDEYETECAQTFRIALCNDEWWMTRIHTRKISSRGIRKRKMAASPKTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1K2</accession>
    <name>A0A232F1K2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001258">
        <property type="protein sequence ID" value="OXU24595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1K2"/>
    <dbReference type="STRING" id="543379.A0A232F1K2"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="65508" checksum="269C74738CAD68FC" modified="2017-10-25" version="1">MKQKLNAAARLARLCRREITSESIAAEPASASSATNEIQAKPYEEIPGPKPIPILGNTWRLFPVVGQYTISDVARISQLFYEHYGRITRLTGLIGRPDLLFVYDADEIERLYRQEGPTPFRASMPCLVKYKSEVRGEFFGELPGVVGVHGEPWREFRTRVQKPVLQPQTVKKYITPIEVVTNDFMKRIEDIKDENDEVPADFDNEIHKWALESSFESQQSSMQLKRSFSYLDHSLFTGIGRVALDVRLGCLGSGELAPDSEPQKIIDAAKYALRNVATLELKAPYWRYIPTPLWTRYVRNMDYFVEVCMKYIDAAIDRLQEKKKNGVEMHESELSLVERILAKESNPKMAYVLALDLILVGIDTISMAVCSIMYQLATRPEEQEKIYEELTRIVPDSSVPLTTRDLDQASYMKAFIKEVFRMYSTVIGNGRTLQNDTIICGYHVPKGVQVVFPTLVTGCMEQYVDDPRTFKPSRWLKEGADQKLHPFASLPYGYGARMCLGRRFADLEMQVLLAKLIREYKIEYNYEPLKYKVTFMYAPDGELKFNMINRNRVQQQQQQQQQQQQMNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1M4</accession>
    <name>A0A232F1M4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001307">
        <property type="protein sequence ID" value="OXU24410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1M4"/>
    <dbReference type="STRING" id="543379.A0A232F1M4"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF6">
        <property type="entry name" value="RE22408P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58981" checksum="5F32EA896E9E8719" modified="2017-10-25" version="1">MFANDVFCFGCMRPLPGYLSSKTSYTRCSKCGVAALCNRACEDSGLHSTAECDLLRAKRDVMLENMEDLMHTLVHLKLWLVMSAGSDQDVRERLSKMEAHMNERRGNEVWFEREANVVDVFRRFGLVRSENEAELVQWLCGVLDVNSFELRTPVPGSNGNNGSPLLRGLFLEAALMAHACRGTAHIAVDDRFQMTVYAAVPIPAGETITFNYTSSLLGTIERQEHLQVGKYFRCECSMCVDPLEHGSFVSCILCPRCKKDYVAIQNARDKDPYGRKTKWQCRKCKRIFRGCLIKSTIEIGKDLIEDVGDGNSKVAIRYRIHYIKLCVYIILIYAQAMESLLERLSSTFHTNHFVMLTLKQKVLAVYRKEVGNLNPQRKILQKMLEIGKQVVDVLDIVEPGISRLKGILLYEMHLPIAILANRSYASREITAERLVSCLEESQACLKRSLQMLLLEPASTPEGMLAKRALQEMKHLAQNVADARTLQLRQMSTPQEDHSSVKKPERRGSHRQSKNRNRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1V8</accession>
    <name>A0A232F1V8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein JTB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_006408</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the JTB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001279">
        <property type="protein sequence ID" value="OXU24513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1V8"/>
    <dbReference type="STRING" id="543379.A0A232F1V8"/>
    <dbReference type="OrthoDB" id="206598at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000725">
        <property type="entry name" value="Glutathione S-transferase, C-terminal domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.220:FF:000001">
        <property type="entry name" value="Jumping translocation breakpoint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008657">
        <property type="entry name" value="JTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13369:SF0">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05439">
        <property type="entry name" value="JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="18">
        <location>
            <begin position="484"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU24513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="697" mass="79525" checksum="45D85FD4D667B558" modified="2017-10-25" version="1">MIESCSKKRMLLGITLLGGLTILVLIVESHWTDTTGGKVFVENVESNSTCLSGEDFKIISECHPCSAFEIASQSIGVCTKARYKEIIECKSGEKITRSCDRVAWLEERTFWKFESITFVGAILSCIAVFWRENILRQRVIRKVARQLRGSVPIETLVTLFTIKYCNSDVQIRLVRDANVSAENSFVVDISTFQYKFIEYSEVSEIASCCELPNLEENDKSCIAGLCATLRQIIRNMLFTDPDHYSRSLLGFKESCLLACSEASIWTRFCEVDIVSTLKSTFEQNQDGILPMSLARFEKHMSQPVRLHNIYKYTMSKKFTNNAQQDKSTLPEHTFAEGLTLTLADIIIFICIHTLFTFIDRKQIRDIIPLTMKWYENMLTDDHILRSLDILRIENSYNKEVMVNYSLPHTENQSLYKSDPKRYKPRSRIYTRQDDIDYSLGKIKDHEVPVKLDDLFGQEKIVDWSAIPHEATPAGGDLPNTRLQRKFQQLESLCKPVLKLAKDGDTIVDFCSGGGHLGILLAYLLPKCNIILLENKAESMKKAKDRVVKLSLNNVIFYQSNLDYFKGHFDIGTCLHACGVATDLVLQQCIDKNAAFVCCPCCYGSVQDCHRIVYPRSQVVKDILDNRSYLVLGHSADQTHDVENVKTKQGYECMMVIDTDRKMQAEENGYQVYLNKLTPETCSPKNHLLVGWPSRLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2K2</accession>
    <name>A0A232F2K2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_002802</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2 12"/>
    <dbReference type="EMBL" id="NNAY01001164">
        <property type="protein sequence ID" value="OXU24925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2K2"/>
    <dbReference type="SMR" id="A0A232F2K2"/>
    <dbReference type="STRING" id="543379.A0A232F2K2"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12086">
        <property type="entry name" value="DD_cGKI-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000096">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000035">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000064">
        <property type="entry name" value="cGMP-dependent protein kinase, isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF111">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0140">cGMP</keyword>
    <keyword evidence="9 12" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="108"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="226"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="364"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="20">
        <location>
            <begin position="624"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="647"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="370"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU24925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="675" mass="77471" checksum="BCD3BA06FB02D117" modified="2017-10-25" version="1">MDSILDLKRLLYERSEALRRRDETIEMLERALEEREATIRYLQNEIDKFRQIVDLGRVAPGPLNPTQRLKRQAISAEPTRNDSKPIPKFSKPQRSRELIKAAILDNDFMKNLELTQIREIVDCMYPVTFPAGHIIIREGDVGSIVFVMEEGKVEVSRDGKYLSTLAPGKVLGELAILYNCKRTATITAATDCQLWAIDRQCFQTIMMRTGLSRQAEYTDFLKSVPIFKALPEETLIKISDVLEETFYNNGDYIVRQGARGDTFFIISRGQVRVTIKQPDTTDEKFIRTLSKGDFFGEKALQGDDLRTANIIADDPDGVSCLVIDRETFNQLISSLDEIRMRYKDELVVRRRLNEEFRDLRLQDLRSLATLGVGGFGRVELVQIAGDNSRSFALKQMKKAQIVETRQQQHIMSEKRIMGEADCDFIVKLFKTFKDRKYLYMLMEACLGGELWTVLRDKGHFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLDSQGYVKLVDFGFAKRLDHGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGADPMKTYNIILKGIDAIEFPRTITRNATVLIKKLCRDNPAERLGYQKGGISEIQKHKWFDGFNWEGLRARTLEPPIMPKVLSPMDTTNFDEYPPDAEPPPPDDISGWDNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3K6</accession>
    <name>A0A232F3K6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001115">
        <property type="protein sequence ID" value="OXU25089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F3K6"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF702">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="162"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="921"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1347" mass="154626" checksum="0B56502DE499F450" modified="2017-10-25" version="1">MLSSVRTKGILHINLIIIERLNARVVGILEKTVPAKYVRTAKVLSGVIRQRIENTGCKYKDIYILKLKLPNDKEQDITASMFSPANLENVLEEVISTLPPEDETPTLELSMEWCKEHRGVRVPKNVSRPVKPATKYKSCTESYDNSSKILCNDTETLKPNYVGLVNQAMTCYLNSLLQALYMTPEFRNALYNWEYKSSEKNTTNSNTTSNSIPYQLQKLFLNLQTSQKTAVETTSLTKSFGWDSNEAWHQHDIQELCRVMFDALELTFKNTAQADLINRLYEGKINDYVKCLTCNTEKFREDTFLDIPLPVRPFDTNVAYGSVEEALEAFVKYETLEGNNQYFCEKCDKKSNAHKGLKFTKFPYILTLQLKRFDFDQNTYHRIKLNDKVTFPDVLNLNTFIESSSNKESPLNEEDAGMSVKCDDSITIDSSTMDETDYASSDIVLSNSNHLSNPDQDDDEGIDVSNGMSSSSSSMQNNNAEKIREEYAEAKGPYIYELFSIMIHSGSASGGHYYAYIKDFRTDKWLCFNDQIVTPITQDEIQKTYGGGNRPGYFSGAYRSSTNAYMLMYRQIDPKRNALPMQAEDFPPHIKELLEKMKKSEEERNCYIDEPSFLDRRYNRPIYYRHPATGEVKEVFVSFRMSMTLRQIAEATYKEANLDSLVDFEQCRIVNYLPRYDLIECSYEDCDHTKLEDLFDYTRMNLLLDIRPKSEQFESYLPMPIITKVYVIDALDTNIVDGPKYIRANQKQTIQEFKQELKKHFNLDPNTVQLLCKEIQQNKLLDDDLVLESKYSGQLFKIGATDSYEHEMLMNLEESVFFKMCEYLDDIVTFYVDTSKVTKEQLVKQGIPTLEEYYKEEKTQENTNSLFNCVTDEMSKINISSSYNNSAKNHSQIATNSDMTDVYEMILQNKGAIDKEECKVQETSNSEDSSLSDSDRTLVGDVPEESELDCESALNPADRFTGSHFYPNSLINQNNEILKISVDNRIKEDELKEKLESSLNIPKDYFKLTEFVAEDACSYSSSRNKLVLKEDQKYSICLGRICNSNELKLDVYRLDMQSMLHCLAQICQVTPTSLRSDTNLTMPKGTAYDMGRRYLTDLKQAPLARLSTLYVNKSTTVGNVKKQIRAELKRKNILDLQDGKWLFVDYNEEILGDVWSNDENRLHSTDGICLCPSDSPICVKKWNRKDMQLENPEPISVTGDNINIKLKETVSSMSKIPLECLELCPMVVGKQSALDKIETFKWKSDINNDEIDCKTYILYSSRVETEIKHKSSYTNGKVHLSFASKFSKFQVEEYLTSFRGNERFERDTKNTHGGRKEQYAAECNKSSGSLQLAANSDDLQSTKGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3V9</accession>
    <name>A0A232F3V9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001092">
        <property type="protein sequence ID" value="OXU25168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3V9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="68" mass="8140" checksum="8C7C30AE0CFD452E" modified="2017-10-25" version="1">MPELQVRFPLRKKKLFSFFLPNIIKWRGSATKASLRSRRSRFACDTIYFYIGVRILHDTEKNAYCYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5L0</accession>
    <name>A0A232F5L0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000980">
        <property type="protein sequence ID" value="OXU25627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5L0"/>
    <dbReference type="SMR" id="A0A232F5L0"/>
    <dbReference type="OrthoDB" id="7691224at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="11447" checksum="242EFE2FB7118274" modified="2017-10-25" version="1">MINNQQRIVLSTGDAGIQHQPVSAKPSIVSVSSIDSDVSDRRDIREALYTGIFKRHRKTILVLGSFLKMLRKYLDRMHALNQVFAPIATRLDTVVEHKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5P7</accession>
    <name>A0A232F5P7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000941">
        <property type="protein sequence ID" value="OXU25808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5P7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12507" checksum="7A9FE146E21EC563" modified="2017-10-25" version="1" fragment="single">AQSTEVSRNSREFVSVRWRIDDTFFDVTFTNPAQYHEFHSYLQQHRLPIPRLIQTLPYAKQKETAAVDRKQSPRISGGEILLFHRNFKSAAKNSSAARKVPRQPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F601</accession>
    <name>A0A232F601_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_011808</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000919">
        <property type="protein sequence ID" value="OXU25903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F601"/>
    <dbReference type="STRING" id="543379.A0A232F601"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="18931" checksum="D920E0357ADA1387" modified="2017-10-25" version="1">MLCYIHKITGKTNRLSLIGLLRRNVKQLNKLKSSQKPSRIRANNNRKQVQPPKQATVETTSTIAAAGDSPDALEFAASLGLMSRHQPQHHAEVPARPKSKHQQQEELEFLCRFCGKGYRWKSTMRRHENFECGDKPPSFQCPQCPYKARQRGNLTVHLKRHHQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F676</accession>
    <name>A0A232F676_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000908">
        <property type="protein sequence ID" value="OXU25973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F676"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189571" description="CUB domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40856" checksum="24DB442267044E4A" modified="2017-10-25" version="1">MADHCKANCIYLLLLFFTSTIGKLDSRKNYIPINLDNPAICNPSTDKVQVIDDLRSRGKRDLAILIEPSHVFDTWYVKYNKHCKFRVKATKGDALFAVVQSMSLRRNGTECLDYIMFTSEFGGPPKRYCGKVDFTNGLKRYIPYEEPNTDNQNGLDFIPAMVEEFSAQGKITTEIFISKQPLLPGEKLDLVITYTPCRDYKITEMIGEGFIRIYNTEHVIDTCINLKYICDHYTNCHSRYCYDEKNCTNIMNRIVSDGTGTKVTISAVTTIFLCLIIFTLCLWICRKHKKLCWSPDCAGPSNTVSGSTSGLPMERGEQSAPNPPYVPTAPMLEVAVPSSLHDKDLPPSYDSLFPTQSHAVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6G1</accession>
    <name>A0A232F6G1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diacylglycerol kinase</fullName>
            <shortName evidence="10">DAG kinase</shortName>
            <ecNumber evidence="10">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_016086</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01000895">
        <property type="protein sequence ID" value="OXU26029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6G1"/>
    <dbReference type="STRING" id="543379.A0A232F6G1"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20801">
        <property type="entry name" value="C1_DGKepsilon_typeIII_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000019">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF118">
        <property type="entry name" value="DIACYLGLYCEROL KINASE EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012579204" description="Diacylglycerol kinase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="145"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="14">
        <location>
            <begin position="235"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="565" mass="64019" checksum="98F98CC3C1032314" modified="2017-10-25" version="1" fragment="single">YCPCKILYVLLILMMSGCVQRFKLDDCQLKFEQDLLVIMWVDGFYGCLLPTLSTVIIFVVTVNVVRFLIGEINIHVRDAKKHNWQIIKRTSRPYFCSVCESLLLAMNGLYCDSCGVCADHECLKKADKKFRCKEITLSSNKEPMKHHWVRGNLPIVAMCDICDEECSFEPELLDWWCCWCQRCSHETCKSSINDVCDFGVYKLVIIPPASLEIVNKSSKVRRRLQIRSIVPPLWPNWSPLIVVANKKSGNNEGAEILSSFRRILNPAQVIDLSERDPVAALEWCRLLGDTPYKIVVAGGDGTVAWLLDAIYKLQLNPVPAVAILPLGTGNDLSRVLGWGKEYDSNTEVSATLQAIQLAKKVDLDRWSVSIDAKKGLGFRAHHKSIHMYNYLSVGVDAQVTLNFHRTRESRFYLFSHRIFNKLLYLCFGTQQVVERECKDLDQRIEVYLDDKKIELPSIESIVVLNIPSWGAGVDLWNMNLEDNQVGVQSICDKKLEVVAIYSSLHIAQLQVGLSQPLRLGQAKTVKITLKSPCAIQVDGEPWHQSPCTFNVTHVNQASMLMSSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7S3</accession>
    <name>A0A232F7S3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_007311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000745">
        <property type="protein sequence ID" value="OXU26715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7S3"/>
    <dbReference type="STRING" id="543379.A0A232F7S3"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000343">
        <property type="entry name" value="CCR4-NOT transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="60"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="200" mass="22798" checksum="DDD03DAFFB3CC3BA" modified="2017-10-25" version="1">MYKNFSPRGYNMSRNHKDKYESSNPRRTHTIMSTEDANSGKKSFWPELEITGSIRNLSPNVWQLTHLTALYLNDNSLQRIPSEIGRLVNLRALDLSSNKLRSLPAELGDLIYLKELLLNQNFLRVLPYELGKLFQLQVLGLHGNPLSKDVMTLYGEPSGTHKLLSYMLDNLQGRSLQYAIHLILLQAIHLSSAQPLNLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7S4</accession>
    <name>A0A232F7S4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED17</name>
        <name evidence="8" type="ORF">TSAR_015249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000817">
        <property type="protein sequence ID" value="OXU26347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7S4"/>
    <dbReference type="STRING" id="543379.A0A232F7S4"/>
    <dbReference type="OrthoDB" id="10058398at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="641" mass="72033" checksum="F2243AD548EB3D97" modified="2017-10-25" version="1">MSYSVNVSVEAPIENQIQEITYDGQEIYQAPLTLSENLAKIAQKIDFSKTNGDDVTKEQENGEKSEDESKDPANFQSSLWPWDSVRNKLRNAFTEVCVLADVLAVAKEKRYMVLDPVQQDPIEVKPLVQVHARKKALAGAASVLIMGADRMKSCQNELARTRSTPDFHIELLRLRQNWRLKKVSNSIIGDLSYRTAGSKYNQTGMFEITKAEEEEKTSTSPPASPNPNMPVPSTSSSNKNASALRVTIPSELEGIAYIEVLCKKDEEALCSANINWLNSGSGNKLDPDTHWQQKLEAAQNVLFCKELFSQLAREAVHLRAPIPHMVVGNRIMATVLPGIQLVIILRHSTGNDKKPVPQNTDHDHVLEHSLHQLLREVHHKNTHHPFPHPSSGPLGPSKRRCLAGPTAADRHELLEMTKSQTLLEQIIQQAQHFFMRLRTEYVLDTIAKEFKDPLILSHWNALNSPTQSSVRIVIQTHGYDQLIRTSMVLHVHEKSLKCVCKDGRVMHMSYEPQELRDLIFCQIYQHQISAVQGLAKCMGWQFLANSSHLGLGAVEPLGNASSCILASPNGDRMIAVRCDPHTKIQVSIAHSPRKDFFPGQLVKERKWENLGGSFKEVRWDKMEGKNFLNKMELLMASLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F973</accession>
    <name>A0A232F973_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000707">
        <property type="protein sequence ID" value="OXU26867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F973"/>
    <dbReference type="STRING" id="543379.A0A232F973"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028054">
        <property type="entry name" value="DUF4481"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31193">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN C9ORF91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11990" checksum="76C0BF76A068F783" modified="2017-10-25" version="1">MTDCHIDDCETYRYTSDERAELLLLRYALRWSHHFVRHRLALAVDSQERNGRNSIGISVQPPRHCISARCPCQFIEEHLKYKPKGKSTLCNFFKMPNFDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9H3</accession>
    <name>A0A232F9H3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000625">
        <property type="protein sequence ID" value="OXU27325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9H3"/>
    <dbReference type="STRING" id="543379.A0A232F9H3"/>
    <dbReference type="OrthoDB" id="6382204at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="233" mass="24691" checksum="028793B93EE7E350" modified="2017-10-25" version="1">MTFVVNPDAHDSTTKQIQSKLGNYSLVKHLLVDEPKRLFGIEGVPASPAPRGGFVKPADSKPPHGGRGGYPGQPVKHGSSSNDHRSHGLIPAKGPPSGSSSSSSSVGMAGSNSGAAGQSSSGLTGGSSASMQRQMHTASVRLPKLSFDGVSSKFSTPELEHILKWMEGVHECLRYCPRVEIERAAPLSLLRTKTRLKKPSGVSQSIISQVRNHQDRQLYSVLGSFPLSSADEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9M4</accession>
    <name>A0A232F9M4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000651">
        <property type="protein sequence ID" value="OXU27170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9M4"/>
    <dbReference type="STRING" id="543379.A0A232F9M4"/>
    <dbReference type="OrthoDB" id="7698113at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="532" mass="59889" checksum="3B5401C0D6E9C2C1" modified="2017-10-25" version="1" fragment="single">MSKRKVEDPEDLDSRATKKQNALFRECLKYLEKKRQSGEEHPGSDQDYDSDPGSFYDKDFSADDDEKDAEGSKENRADEKADLAEEALDEEVKAVLGEDPTESKALQIKLHTSVQRRWKFWFENGLSREDKDSLLGKYGCPLGIEVPDLNPEIALKLQPHAKTRDSLMCKRQLLAGSALNAIGALLDSLMCKRQLLAGSALNAIGALLSTFIEEKEDVDKRDCLEKLQDAGKLIAELMNSQTKSRRALILAGVDKQTKTMLDETKPDKFLFGEKLSEKVRESKNLEGVAFKEAARKEAVLIKFRPPTRLQFTERQRTHRLQGQLPQSAIQPESAVSGSEPVQKSGSAEIDNVGTVVGRVRFFVKAWEKITSDKFILGCVAGYKIVFFTEVFQDRPPKQKDFSQKEFRALEISISALLRKGAIEPCRPHKDQFLSSYFLVPKSDDSSQYVLELPLNKRKVLLDCIESVRSKRRCSILDFAKLIGRLVAACPAVEYGVVYTKALERVKTIALVKNEFNYNEKMSVPKSILPDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9N5</accession>
    <name>A0A232F9N5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat EBI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000577">
        <property type="protein sequence ID" value="OXU27581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9N5"/>
    <dbReference type="SMR" id="A0A232F9N5"/>
    <dbReference type="STRING" id="543379.A0A232F9N5"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000001">
        <property type="entry name" value="F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000014">
        <property type="entry name" value="Putative F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="382"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="55932" checksum="3D6F056B0A011803" modified="2017-10-25" version="1">MSFSSDEVNFLVYRYLQESGFQHSAYTFGIESHISQSNINGALVPPAALLCILQKGLQYTEAEISIGEDGTEQRMVESLSLIDAVMPDVVASRQNQQNQQKQQLKTEIQDTNGEEVVTSNESVGNNDKGDRSEMEVDDQQQGQGGGNANSVKIPANKATKLQGHESEVFICAWNPATDLLASGSGDSTARIWDMSDNSQSPNQLVLRHCIQRGGTEVPSNKDVTSLDWNCDGSLLATGSYDGYARIWTTDGRLASTLGQHKGPIFALKWNKRGNYILSAGVDKTTIIWDAASGQCTQQFSFHLAPALDVDWQTNTSFASCSTDQCIHVCKLHVDKPIKSFQGHTNEVNAIKWDPQGNLLASCSDDMTLKIWSMKQDTCLHDLQAHSKEIYTIKWSPTGPGTLNPNMNLTLVSASFDSDVRLWDIDRGACIYTLTQHTEPVYSVAFSPDGKFLASGSFDKYVHIWSTQSGQLVHSYKGTGGIFEVCWNSRGDKVGASASDGSVFVLDLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAP2</accession>
    <name>A0A232FAP2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_011269</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000593">
        <property type="protein sequence ID" value="OXU27503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAP2"/>
    <dbReference type="STRING" id="543379.A0A232FAP2"/>
    <dbReference type="OrthoDB" id="302535at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000371">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="372"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU27503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="657" mass="74073" checksum="7E0491C33551FB83" modified="2017-10-25" version="1">MGSHRLVGEALQHILQGFGWKVAALLFHNHAMASSRGNSKCHFTLGAVYTALNQTSMYKSFNEEDSTANDYRNLLTFVSKSARIVVMCANATTIREILLAAEELGMVDSGEYVFFSIELTSSDNSTKEPWRVVGDTPERNEKARKAYQALLTVTTRTPDNVEYLNFSREVKSLAQSRYNFTFGNSSVSTFVTAFYDAVLLYALALKESLPDKPGEVNLDGGNLTRRMWGRSFKGITGYVHIDENGDRIADYSLLDMNPETSKFEIVANYYGANKTLEYIPGKRIHWSGDRLEPPPDTPTCGYDGSLCPDNSLPGYAILSIVLSSIVVFLVVGSVFIYRHFKLEAEIASMTWKVHWEDVIVMPSEKFKAGSLYSLAPNKQRGSQLSIYSEDNMSLPGGMDRRSFVPTGIYKTSKIAIRPIPRNKVEISRPLLLELKRMKDLQHDHLVRFYGACVDPPHCCLLTEYCPRGSLQDILENEQMKLDKVFRGSLIHDIVRGMGYLHASDIRSHGNLKSTNCLVDSRFVLKIADFGLHELRKPHPLDPDEDRNSYAYWRKQLWTAPELLRMGRRPAEGTQKGDVYSFAIIVHEIEMRQGPFYLGNASNLSPRVLIETRVSKILFPSKTNSRIKGEILSTVELNDCARVQALLRLVEGSVLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBU9</accession>
    <name>A0A232FBU9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000475">
        <property type="protein sequence ID" value="OXU28125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBU9"/>
    <dbReference type="STRING" id="543379.A0A232FBU9"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="11">
        <location>
            <begin position="12"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="269"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="613"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="728"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1055" mass="121820" checksum="4E605C19D85ACB0E" modified="2017-10-25" version="1">MEVHEEVQMGIITRIAMKNFVTYDEVVVKPGKNLNLIIGPNGTGKSTIVSAIVLGLGGSPSVIGRAPQIGHYVKSGEQNATIEIDLQNGPNKFVTVTRMFNLQNHTTWMVNKKSATSKQITDLMRTFNIQVDNLCQFLPQDKVVEFANMSPPKLLEETERSVGDPKLLDNHLKLKALRTQQADLEEDLEKKTRLQDREKQIYDSLKDSVGHIQEQNAIKKKLKTLKQKKNWLIFQNKREEFNKAKIGRDEAQNKKNDIAKKLQPVEAAIAKLKSSIQGLEKTAKQHNSEISAKTAKLHKFLDDIEKQEKCIDEIEALCEQKIREEQESDNCIDELREQTNKMENDFRALVAKVGEVGSLQEQLNSNTPQMNQHRVTANELSSQRNFFKEQIDHNSRKIRGEEQVLQQTQDIANKRFELLHTMSADAYKGVLWLRENSHLFSKTIHEPMLLHINLKDSKYAKYFENIIPQRDLTAFVCEDKNDMNLLLRYLRDQQKLRINAVHSDPNRVVNYEPSIPLQNIQQYGFEHYLVSLIDAPQTILSYLVKMYGLNEIPIGNDKVQSSLDHIPDRFRRFFSSNNSYSVSRSKYTGEKSTRQSAIYAGKILSITVDTDKIRKIQEEITLSKEKLNALNDELKTIDEKIVKVQEKIKVLKEIRSRIQGSLDQIQNLQVRINVNEKKIQGMQSNRMSIDQIRSKYKQEIQAAVLKQLQHYRQYNKLLDDLYKNIIINEEFKLQIKMEKNKLANKENDSHDLREEFNNAERDYENLNRELQPLKAELKSAYDTAKESTGGLEPEDKDFAPLMKSFAKLPATIEKLFEEIQATQARIFCLTNDQQEAKRVLDQFNIAKRHLEELDVLIKQRDEELSKVTQQIEKVKGEWLPMLESLVEKINANFSHSFTRMKCAGEVSLIKGDNEMDFDKYGLRIKVKFRDADELQALTRTHQSGGERAVTTAVYMIALQELTRVPFRCVDEINQGMDATNERRIFELIVKITSQCSSSQYFMLTPKLLPGLKYNDSVTVLTVFNAKFMVPCSEFDIHDQCDNIVQAVRRRRLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD29</accession>
    <name>A0A232FD29_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MAD2L1-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000458">
        <property type="protein sequence ID" value="OXU28257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD29"/>
    <dbReference type="OrthoDB" id="6334764at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06581">
        <property type="entry name" value="p31comet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33987" checksum="507EBF9C467DD246" modified="2017-10-25" version="1">MFKSVKKVESNISVDLEEPLTAQSCSQLVIEIIKYIMYQKQQIPFSGDTLIKLYASTKPTDRNYTSMNKLINTLNSITDNLVHELTLDECDVKEVLIVIGATIITPKLCIKLELPNILNKTHIPRLHPYRKPLMTVMRSILGCSEFQEELSTPLFPTNTFVLVQKRDPKKTSEFFIPKPQFALPSRNMACLNIRLNYDENQTFNCECKRMRPDFPVYNDNFKVLRGHCVYMGQHMTWSNPFKSRLREGEFRTRHSCTEDHSKMKKSLNNESNLPYLWYQSKEVLKGFKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEI7</accession>
    <name>A0A232FEI7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000389">
        <property type="protein sequence ID" value="OXU28727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FEI7"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000045">
        <property type="entry name" value="Blast:Protein yellow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF13">
        <property type="entry name" value="DOPAMINECHROME TAUTOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013212039" evidence="6">
        <location>
            <begin position="17"/>
            <end position="2792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2194"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2219"/>
            <end position="2241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU28727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2792" mass="315991" checksum="B876AF748E5D63A5" modified="2017-10-25" version="1">MYVVLCICASIGAVSCLKSSLLTPDLEWKYFDYEWESESKRNTFVLNGDYDYKNNVPVDADRSEDGRTFVTIKAGPGVPATLNTVSKKVGPSGPLLYPYPDWSWHIKNDCNVITSVYHMAIDSCDRLWVLDSGKISGEYVCPAQLLAFNLRTDKLEFKKKIPPNAAEDRYGNGLLYNLIVATDGRLCNNTKVFMADARGYGLVVWDGLRFFRVEGKVFEPEEKYTSYSIAGEKFHLADGVRAVALSPAMGMDDGERYLFFRPLASKSLYAANSNDLAKVGNRKRMNYFGSIDILPSQASSLAFSSNGTLFYGLTKEIGIGCWNMHNPLTPNYLELVLIDKERLQFISGLKLIRNSRFLAEPQEELLILSNRLQKVYGSSLDYNEINFRILRLSVKALINGTNCDTITTLSLTSAENVKPRPKPNLKSVYEWKYIDYLWESETQKQEFVKSGKYDHKNLIPIDVDKARDGRVFVTVVGVKGSAPATLTKVSDKVGPSGHLLVPYPDWSWHTMSDCQRITAVYRVAIDPCNKLWVLDSGVVDGVQVCPAQLLTFDLDTDQMVGKLVIPEDIARDPETGKGLLVTPIVDNDGPLCANTTVYMTDEEGSGLVVWNSVRLFRLKSEVFQPEEEHANIKIKDTSFHAKKGISGAALSPRIFPQTTRFFTFRPLASRSLYSSDTRVIKRSTYGDKIKFYRGLDVLPSQTPAQAFSSEGTLFYGLTEQIAIGCWNRYNKMIPKHFQIVAADEDRLQYASGMKVIPKVVAQSPEELWVLTNKMHEVLNGLCDYDKVNFRILKSSITELITGTDCEMPDAAKQMLEEALDKEQVENGEDEATIWGVIKETIVLWCLALVSATYAYSSGGSFPHVQPSPLVTEYEWRYFDYVWDSPVQREAYIRSGRYNASHMIPIDVDRSIDGRTFVTVIRDVGVPASVHTVSNKRGPSGPLLKPYPDWSWYENVGNCNGITSVYRVAIDKCNRMWVLDTGIVGTDRICPAQLLVFNLYTDRLLFKVKIPDDVAQNKNGEGLLITPIVETYGNRCENTTVYIADVLGHGLVIYNGFRAFRLEADVFGPEERNSNYNIAGESFYLNDGVLGMALSPIQYPGESRYLSFRPLASRSLYAADTRVLQRSIDGTRIKYYRGIDVLPSQASAQAFSAEGTLFYGMTSEIAIGCWNMNRPLQAEYFKIAVQDKQRLQFTSGLKVVSNPVLFPNGDQYLLMMTNRLQKIYAGTQNLNEINFRVLRAPVRELIRNTIVLWCFALVSATSAYYRTGSFSNDHHSSPLVTLYEWKYFDYVWDSPEQRQAYVTSGRYNASNMIPIDVDRSNDGRTFVTVIRDAGVPASVHTVSDKEGPSGPLLRPYPDWSWYENTGSCNGITSVYRVAIDKCNRMWALDTGIVGSDRICPAQLLVFNLYNDRLLFKVKIPDNVARNKNGKGLLVTPIVETYGYRCEDTTVYMADVEGHGLLIYDGIRTFRLEADVFDPEENNSNFDIAGESFFLEDGVLGMALSPIQYPGESRYLYFRPLASRSLYAADTQALRHTLDGSRIDYYRGNDVLPSQASALAFSADGTLFYGLTSEIAIGCWNMNKPLKSEYFKIVVQDKQRLQFTSGMKVIPNYRNEHLLMMTNRLQKVYAGTLSLDEVNFRVLEASVRELLIHNPSILGIIILGAVIVTSHKLDTVYEWKYIDYLWDSNAQKERYIRSGDYAYENIVPIDVDKARDGRVFVTAIRNQGVPASLATVTERVGPSGPLLRPYPDWSWYKAGDCDGITSVYRVAMDECNKLYVLDTGYIGDNYTCPAQILIFDLGTDRLIDRIKVPNEYSQNRDGVGKLVTPVLEVNGPNCALESLFMADVNGRGLVIWNNQRFTRLEARVFDPEKPLANVEIAGESFELEDSLMGMAVSPKIYENEGSDLLFRPFASRALYAADTRVLARSTYGDTVRYKESSDMMPSQATAMGITSRGTLIFGLTNDTAIGCWNRYREMNRSQVQIVAQDRTRLQFASGLKVLPSSRTRADEEVWVLTNRLQKIMTGSQRFDEVNFRVLKSPVDKLIRGTVCKPPRWSEIKTRPSQEHVSEFWSTHPNPVFRYDRDFIQSHNHHASTWNKPSGMASVMPWLVTMSLLGFREFAESSGPAVHISQELEAPPPLPQLSPLDFVSPSSASFDDPAFDNEETPVHVDCDFPSNHKPSNAIIHRAKEKPHGFQIDPNFAPNLQSLQPDNKKNERNLDSFQNGANSNNIAESSKPNLQPNQVNQSERFFAPGHTFKPPKENGFKDEYAGPSMHLAYYWKTIDYEFDSDEDRNSLIYSGTFIPENNLPLGLEIWKDKIFVSMPRWKKGIPATLATIPTRSHDKSPKLKPYPDWRWHHLGNCQGLTSVFRMQIDECDRLWVLDSGKIDITDDPLQICPPTIFVFDLYTDELIRAYTLPHDQIKEDSLYSNIVVDVRNGECDRAVAYAADVWRFGLIVYDFHNDSSFRIQHHYFFPDPLSSRYNLHGLEFHWTDGLFGIALTPVDVNNEKTMFFHPMSSFREFAVPLSALRDKKTAEDSPEKFVPVGKPRAKDYGHSSGSTIDRNGVMFFNMVTRDSVWCWDTRKEYIPQNLGVIGSSNVSLVFPNDIRMDHEEDQNVWILSNKLPMYLYGYMNKDEVNFRILRASAKEAVRNTVCDPNYIVPESLPSYDINTCRFGIMLSKYLSRRADCVAHVIPFALNNFIFQDARGLSRFILISPLNLRRRFCPSRSVVVDRLGIWKLQLFEENMSTQIGIQFVSKEQPLVLQDMLVLEVQSLAHLIQCSEASLQKKISAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFG0</accession>
    <name>A0A232FFG0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000284">
        <property type="protein sequence ID" value="OXU29494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFG0"/>
    <dbReference type="STRING" id="543379.A0A232FFG0"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF41">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013031392" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="66785" checksum="E9417A58D55B91A5" modified="2017-10-25" version="1">MWKIAWFMVIICCVSRVTSVLEIDSIVVELVKNLDYEQLVVFKNSEYFFRNSGLKIVKLMEQTKTILVDIDHEQIYSLSLGISRTSTLCIILQNEAIGANDVMRFLVEASPVSTRPKCLMFADNDTYSEESFASILLQAWSLKFLDFTILFVNDEGQPQMISYNPFTKSYITEEVTNTSLLFPDKMSNMNEYTLRIPIYYLPPYNSFVLQDGAIASVDGYDYPFIEIFSKKLNFSLQYLIVEERSNITALFEKLLLLLENNKVSILPKPLYLGTHYYGRDVVIGKAYRDTNYVLIVPVLPMSRMRDYMWMLTKLAFFPTYVLILKLILSLMRFRLNQWIHLLQMLVGSTLTKQPQKVAERIVFFTVVLLSMIFSTDVLASLTDTKVASNDIPFESYEEIISSNLKVYGRITGSERQNDLFKKLDVQNIKSLSECISKSARTKCCICIAPKLAAMYLVDEFENKSEPTLKISRFKLYSDMLAFGFEKASPYVEKIDLVLQTLVEAGVQSAWKTRQSYSTVKDRKERDKRRNQKEDSSEKIVVRFTAMLLVFHVIATVVFLVELLTKRFGPRVRRMFVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFP6</accession>
    <name>A0A232FFP6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000314">
        <property type="protein sequence ID" value="OXU29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFP6"/>
    <dbReference type="STRING" id="543379.A0A232FFP6"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="40"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="473" mass="51446" checksum="587B268A56C1AF56" modified="2017-10-25" version="1">MGGEENVGVTTGQPNLYKQDLSQLDVTKLTALSREVISRQATINIGTIGHVAHGKSTIVKAISGVQTVRFKNELERNITIKLGYANAKIYKCDNEKCPRPACYISGGSSKDDSFPCLRPICSGRFQLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHIVILQNKIDLVKEGQAKEQYDQILKFVQGTVAEGAPIIPISAQLKYNIEVLCEYITKKIPVPIRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGMEIEVRPGLVSKDSEGKLTCRPIFSRIVSLFAEQNELQFAVPGGLIGVGTKIEPTLCRADRLVGQILGAVGALPKIFIELEISYYLLKRLLGVRTEGDKKGAKVPKLSRNEVLLVNIGSLSTGGRVLATKADLAKISLTNPVCTEIDEKIALSRRVEKHWRLIGWGQIRGGETIEPVSDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFU3</accession>
    <name>A0A232FFU3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000306">
        <property type="protein sequence ID" value="OXU29328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFU3"/>
    <dbReference type="STRING" id="543379.A0A232FFU3"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="168"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="674" mass="75988" checksum="A342E94BFA75F181" modified="2017-10-25" version="1">MRGARTGTRPVKQNYPSSSPPPRPLPDVSVNRSSSREGCCILQSKASRGRHQSAAIRVTPYAFHPRWRPMCSAFVVLQASVSRDTASPGPAVTCDQMKMKRCTKLDVINATVESYLKRRRYQDTDIFKKPERANCRSSEEMTLSVTAECGTSRDNSIVFSAISNDVVAADQAYQKLKHCINGLRNEKLRMELRGILYPVFCHLYLEMLHAGNRQAAVQFMRSYQGDFTSDTEKDFLDELSSVFSIQDIELRPLVNVFRTRKYKVDLSDEAHIILQKFLTKYGHVILMQVINTHVTVIKNLSDLYASVDENEEDSEKKADVMINGHVEQPCGTGVDREMRELQEAIRLIRNTAHQPLRIFTVNNAIENASCGIITPNMDKLAAGFSTAEIRLWGIGETVLTRPRFRNPSITLACDPSPSVEILDEDEIDEAGAVVLRGHSDVIHDMRFIPEPEILLSVSSDKDMRAWRLNDYTCAAVYSGHNYPIWCMDTSVFNLYIATGSHDRTAKLWSLDRTFPLRIYAGHFLDVNCVRFHPNTQYLATGSSDKTVRLWNKDDGNLLRVYVGAQSSIFSVAFSPDGKYLASAGDDKSITIWDLATNAVLTELKGHQDSVMNLDWSSDGEFIASSSLDGIVHLWSTQECIKTGNMYRFIESYVNCQSSDIRDELFKYIVSTLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGY1</accession>
    <name>A0A232FGY1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Aminopeptidase</fullName>
            <ecNumber evidence="24">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">TSAR_007891</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">Alberta</strain>
            <tissue evidence="28">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22 24">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="24"/>
    <dbReference type="EMBL" id="NNAY01000207">
        <property type="protein sequence ID" value="OXU30026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGY1"/>
    <dbReference type="STRING" id="543379.A0A232FGY1"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF290">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 24" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 22 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 24" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13 22 24" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="27">
        <location>
            <begin position="80"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="25">
        <location>
            <begin position="307"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="26">
        <location>
            <begin position="610"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="23">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="28">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="OXU30026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="963" mass="111322" checksum="DEC9AEE1A2D8EF57" modified="2017-10-25" version="1" fragment="single">VRFCDYETSNTLIIFYYPNISVLFRIMYSPKKVPLLCFLVATFVATRCSEHVGTTATVDEEINNESQNTTDYRLPDNVIPNEYYIRITPFIMPDNFTFDGVVGINATVTKSTSEIVLHVDDITIHNVTVSSIDEDENSLAQLDVENITTKEKYHFLIIEMKSPINAGTNVTIDISYTGELNNDMYGFFRDWIKVGNDYKWVLGTQFEATGARKVFPCFDEPGLKATFRVVLAVPDNYAPISNMPIKTIINTDANQTIVEFETSPLMPTYTVAFAVVEYASLSIPMTEIQPRLYRVWSNPELANQLPYSLQVIPKILDFFGNKTSLQYPISKIEMIAFPDFPPAAMENWGLLVYSEMFMLYNKNVTPLRIKRYIRNLVTHELAHQWFGNIVTPKWWDYLWLSESFAAYFEYHAHEDELAPWNLESQFVVNEMHEAFVSDAYPSIHPMTHEVYSPDEITSIFDSISYNKGASVIRMLEKLLGSEVFFDALQRYFEANKYSFATPELLYLAFEDALNGSDHRWINVTLTDLMDSWTTQPGYPVVHASFDGDTVTLRQNRFFLQPSENLTSNATWIIPVTWASDSNPNFTDTRSVTWLMDESMQITIPNATNDWVIVNVQQAGYYRVNYDNKMWERIIKLLKSDEYEVLHELNRAALMNDLFNLGRTGYVDYKIVLSASQYLSKETNYIPWRTTFTSLIYLKKRFVGHPEIYGHFKLYVMSLLEPHYQRLGFDENDEDSDFDVLFREILLKWLCDFDHKECVSNSLELFKKLRQNDSFIVSPNLQSAVYCTAMKHGSTDDWNYLWNKLQNTNFAIEKLTILSTLVCSRNTMQLNRLLQAVITPGDRIRKQDIKDIITTMVDASLIGANEILDFMDNNYDKMLKAFGDNSMIEHVLITTADSMSTEKLIEKYAGFIEKNSKKVESIAESLDSALKGVRYDLDWNNRKIPHILDWLKKNYPITAANEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH56</accession>
    <name>A0A232FH56_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000258">
        <property type="protein sequence ID" value="OXU29667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH56"/>
    <dbReference type="STRING" id="543379.A0A232FH56"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10142">
        <property type="entry name" value="HD_SAS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="176"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="672" mass="75936" checksum="4B7994DB1AEA7561" modified="2017-10-25" version="1">MNFLNTIAVGAIAGSDAALQLNNVEVIYSKVQRVYVKPQHKEERQRELRVNVEIHAGLSPVCRKALCVLLADDNDPCFLYSLFITDDDFKVLKAQQGLLVDFDNFATQLICLLEQCHVPATSLSKAPKFLLLLAEEAGDWSFKLVETNNFKHLCHLSLNIAPSNDSDLKTHMAMKIKSLKESIVQKDRDAASLESRLSELTKKLEIKCKELEQYEQKCITEKTQLQMNLSQQVALEKDRLTQAKLEWQNQTEKEKRELEYRHSEAIKQLHTDIAELRMQNASFKDKQSLLEATNKEQLKQLQVLEKELNMVQRDYSTLKKQNSKFETDYHDKEKSINALSTRVAVLEQELKDKTILINKHTEMIKNAKESKQRLEELLAEKESQLQRKQASLKNLSDELVKANEILGKLQNELASTKSKLKLRTSIALEQERLLDNKQKEVGQLESKMDSYAKESREAKAQVDSLKEQIKTLQTQLEEKEKTIKNNDNVISWLNRRLADVHSPLQSATTTTTAVTMPQSMQLTLPRTSKFNPNRFETRTPAPNSSQPMSLSGLPLRNPIVQNPNINQTARSTARSMGVGVSDNSTAINFKTGQISSTSTPMERVNSQSKISNNHGNANSVPAIIENNNVPAPAINGMKPKSASSSLQGGLRRAVMDKPLLPSAYFPKTLHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHJ7</accession>
    <name>A0A232FHJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000218">
        <property type="protein sequence ID" value="OXU29938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHJ7"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="34128" checksum="6E61A8A8E05AC478" modified="2017-10-25" version="1">MIHQYNPFNDDYHAESLSNAVNLFTDKVQNMHGYRIDVGLYEANFKLMIDEEYFGNDVWRVISGLDVSIARAVGRDDTVERSIYLYPISKNAVVKQYGKMNIMATYQVIVVFVLIVLVILFFTTILNVFFPHENWEMYNVILILIFGQTTTAIPSSISERISFLFLILTSSGSFAYIFGKLVEMNYMQMVYLDLRTLNDIVHHKLIPYIPFNVIEIMNQYYYDDPVIQEVFHMQTSNRTLVKNNDEVQECFVSETVGRMLSYSHSLGENDWILSFIEEPIAPGLSIMIFTNNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI52</accession>
    <name>A0A232FI52_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000185">
        <property type="protein sequence ID" value="OXU30200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI52"/>
    <dbReference type="STRING" id="543379.A0A232FI52"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="61" mass="7057" checksum="E441C6CC0D675AD2" modified="2017-10-25" version="1">MGDAEQENTDRGDGDNNKNDKLFTLKKWNAVAMWSWDVECDTCAICRVQVMDITFQQGFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIE9</accession>
    <name>A0A232FIE9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_016717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000176">
        <property type="protein sequence ID" value="OXU30300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIE9"/>
    <dbReference type="STRING" id="543379.A0A232FIE9"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="274"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="684"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="733"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="776"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="903" mass="103187" checksum="1A20091CA29E5684" modified="2017-10-25" version="1">MDKERFTMLLLDPGEIFFEDYSVQIKLQNTTQSEPNDWLDGRLKLCSKSLVFVSKDINQPLIKIQLKDTTLAEKCSSNNNLTGSNDTLLVHCKQYVEMLEGNILAPYKFIHKPAEFQFSFNYVKVDDCLPQILQLMRAATLPTAEQNAMIMAIVHSRQSRFSFDTSWLEDLYEKIVFEVQANKVLPLVINPGRILLTTSRLYFQPYNNMDQHPVLKINLKDIKQLNKRRFLLRQVGLEIKWLRQPDTKPEHFFLATRGQQERDALYANLLAQSSLQIETIHQNHMTMQWQNGSLSNYDYLLYINSLADRTFHDLTQYPVMPWVLQDYTSDAIDLQDLSVYRDLGKPIGALEPKRLERLKARYAEMSEPKFLYGSHYSAPGFVLFYLVRKYPQYMLCLQNGRFDHPDRMFNSVADVWKNVLGNMSDFKELIPEFYDTSASGDFLINSYGIDFGFRHDGMKIADVHLPPWAKGPSDFVEKLRNALESDHVSRNLHNWIDLIFGYKQKGEEALKANNIFFHLCYEGAIDLDTIKDINDRHGLEVQIMEFGQIPKQVFKLPHPKRLITADLLKSEASLLFSSSGHGISKIELKSSNVFQSHKEAVTAVTIISDGIQDDNIVSVGRDGVMKIYSIQTGKLVRSVNLSPVPLCSCVCYQTSTNSSVLVAGSSDNSLIFYDIEFGKVFETLNGHEDSISCLKYSKRHNTIISSSWDCTTKIWRSCEPDKKIKLVDCFVAELDHDSQVTCIDLSRDETLLVSATQDGEIFLWKLDDTYSLLATVKEHNAKINAITFEPDSKNVISCANNKSLSVMDVQTSTQTYITTLEEEPVSLAWIHSFLLIGDLKGDLLMWDPQTAAFISKFYCHQGPLVSLAVSPDNKKVITGGQDRKCNLLQYIIFKKLHELLCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ08</accession>
    <name>A0A232FJ08_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000152">
        <property type="protein sequence ID" value="OXU30530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ08"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="46" mass="5057" checksum="B26AA02E66A4C1A9" modified="2017-10-25" version="1">MIFMAVHSALLRPIVFDLLNDDSATVCSLLSRCVLILIVLNSVIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ68</accession>
    <name>A0A232FJ68_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000154">
        <property type="protein sequence ID" value="OXU30508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ68"/>
    <dbReference type="STRING" id="543379.A0A232FJ68"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000014">
        <property type="entry name" value="dnaJ homolog subfamily A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44604" checksum="3BFB75963CF09398" modified="2017-10-25" version="1">MVKETTFYDILGVKPGCSQEDLKKAYRKLALKYHPDKNPNEGERFKQISQAYEVLSNPEKKKIYDQGGEQALKEGGMGGGGFSSPMDMFEMIFGMRGNDSRRRRKGQDVIHQLSVSLEELYKGAVRKLALQKNVICDKCEGIGGKKDAVEKCSTCQGTGYQVQIQQLAPGMVQQFRSQCGDCRGQGERIRPKDRCKQCNGKKTIRDRKILEVFVDKGMVDGQKIVFTDEGDQEPDREPGDIVILLDEKQHDVFRRSGNDLIMRMNLELVEALCGFQKVIQTLDQRDLVVTSLPGQVVKHGDLKCIPGEGMPVWKDPFNKGRLIIQFVVNFPASIDPTIIPTLEQCLPPREEVMIPDGAEECNLVDLDPEQESRRRDTRQAYEEDEGGPSRVQCATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJG9</accession>
    <name>A0A232FJG9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000156">
        <property type="protein sequence ID" value="OXU30457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJG9"/>
    <dbReference type="STRING" id="543379.A0A232FJG9"/>
    <dbReference type="OrthoDB" id="7699652at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234852" evidence="2">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="337" mass="36497" checksum="676142A89EF25BAF" modified="2017-10-25" version="1">MSWITVTATAIFFVVGVTCSPIDVSKPATELLPPEVDSVPTLATDLMPPSESAEKPENNWPATDLVPPPLPEEKTHVKKVPATLFLINIYAVKNSTAEDSNDVLHDDVIEEVPDESSEPLAMFILVVEEEDEDHPVSLDEVAKDLEEEGFSVEKVAKDGETRLVKVDLNSVESMVKFDGENKNNAIEQIIAEAAEKRAQEAQEATEQPELDDSSKLMKVRRKRHLCLKCMLDEVKQYKHHSSGGCGGGCGGGGGNYYQPQPVQYQPVVMEPVHVQPVIVQQPVQRPYYPQPQPQPQPQPTCNVCGGGNNGYGGHGGGSSYAQASAQASAQASSYGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJK2</accession>
    <name>A0A232FJK2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000114">
        <property type="protein sequence ID" value="OXU30855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJK2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8523" checksum="5FE2FDA872B95469" modified="2017-10-25" version="1">MFTWSTLTKAYSNIRIFLKSNHHITKIQHHSNFTDLIFISDLYKILAIGSAVLLFDLHGFELKYQYFIKDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK54</accession>
    <name>A0A232FK54_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_002600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000110">
        <property type="protein sequence ID" value="OXU30879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK54"/>
    <dbReference type="STRING" id="543379.A0A232FK54"/>
    <dbReference type="OrthoDB" id="186786at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="79"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="386" mass="45365" checksum="89F76EB81649EE73" modified="2017-10-25" version="1">MDRTLRGMLYCAMWYGSILSGFLFIACPMLPLLLISPPTFRKCGELLFSCWEMYPTALMEFFGMKVVVSGDHILPNDSAILVMNHRTRVDWNFLWGAMYQACMPNIAAHKLKFILKDPIRHIPGPGWIMQMNGFLYITRRWEEDQGRLSRSLDYLVSLRRRSQLLIFPEGTDLTVSSKQRSDKYAMSHGLPVYTHTLHPKTTGFSYLVRHLQQADYLDAVYDLTIGYPDLVPQVRVYKFITWFILINHQSELDLLNGKVPDEVHFHVRRIPQSEVPKDEAGLRNWLEERWQQKERALEQFYVDKRFPSEPWPESSRMPLRIAFVFWTLLSGTMLLMLVISPIFQLWTLLHALFFIGISLFTTGFNQLEMGWYWKWRSFVCKDTKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKC4</accession>
    <name>A0A232FKC4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000087">
        <property type="protein sequence ID" value="OXU31125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKC4"/>
    <dbReference type="STRING" id="543379.A0A232FKC4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF48">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="126"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="401" mass="45868" checksum="E8D54362017E380B" modified="2017-10-25" version="1">MALGKRIEVFKKNVQLAMANAVGPEVQIVDYKLRPYSEVKEGYVAVHYALAVNYKLPNNAQVQVYHFFVKSAHSLDVENAEASAFQDGLPFPREVNFFNKIVPSMLKHLKGDSFAPKCWLAIKDMIFFEDLGLIGYSTSKLKVQDYSSLKCLTSTLARFHASSLLAETELGKPLNQVDPEIFEDVMFLQDKRFLEGFLNNTLTMVPDLVKLFGFKSPNIDKLRDFLIAAAKPSSNKINVINHGDLWRNNYMLNAGNPQKCILVDYQCLRYASPAIDLNMMMYINCTPEQRKTHERELIEHYHSEFCTTLEQSDLSLRIPEFEEIWKTYEEYKLFGVAFAAMYLPGLLMPESEMGKILEDPVSFKKYLFENRSEFVVPLVNSNPEYGSAIKEIIRDLVEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKD9</accession>
    <name>A0A232FKD9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_001895</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000105">
        <property type="protein sequence ID" value="OXU30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKD9"/>
    <dbReference type="STRING" id="543379.A0A232FKD9"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000020">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218133" description="TIR domain-containing protein" evidence="12">
        <location>
            <begin position="40"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="790"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="845"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119556" checksum="503F3B79C0CDCB73" modified="2017-10-25" version="1" fragment="single">TRGSALCSTMVRLKCNCPPVIAWLLAVVVILSAATSSVADVCHSDRLLKNADFEVRCTNSPNLQVHILCKTSNNNTWSNFPRERLNLIKVESTIFRKCSFDSDLNLLDITSKFLNLRSIDRLVFEHSLGPPGRENLRGFNLQRLQIVDNDFVELPADMLHDVKVDELRVERIPLRSIPRGFFGNSSEISSIDIVGTKLNHIESDAFSSLSKLRKLALYNNNIETIAPDAFDELVNLRFLDLGLNKLHSLPGDVLKKLAKLEIINLSQNEFDELPGDLLQIGKSRLQKFRLSHNRGKLKTLPSGFFRGLSGLNETELTSNGFTSLPADLFNDSINLTSLNMNNNSLTSLPPNIFDNTNLRVLGLSRNKLETLPQDIFSHGNLQTLDMNHNRLRNLSKDTLAELVKLETLQVSHNDLTYIDGDACKILKELRNVDLSYNQLTLDHPNNSMSILLDCKNIVDANLSHNKITRIFGDWLYKSQLKNLNLEYNDIRYVSVPDLRILRPDAVLNLKNNKITTVNLTGLVETVEQYNKHNKNIFRNAKVYLDNNPLHCDCHLLQLFEYYNRTMNNEIYSYIKLEPRDLKCQSPVQFTNISITTIGLDNLNCPVKTNVTTDACNNTCTCWDYPGKKVLAVDCSYRNLTSVPKDVGNPNNRSIELDLSGNKLLKTPAMNTSYLLNVTVLNLSSNNISTVTLSVFSRNLQKLMLHNNSISRLDNSVVEYLSDYSTLSKLTLYQNRWICDCEARNFLIVVQKKLSQKQSQTLHTIDLQEDTCSGTNRLFSSMTVNELCEGAIAIIVVSCLLIALFGVILGLLAALYYRYQKEIKVWLYSKQWCLWFVTEDELDKDKMYDAFISFSHKDEDFVEKEIVAKLEDGPKPYKLCLHYRDWLAGEWIPAQIARSVDESRRTIVVLSPNFIESIWGRMEFRTAHSQALSEGRARVIVILYGDIGNTEDLDPELKAYLSMNTYVKWGDPWFWDKLKYALPHRYEPSKRRTRTARIIENHLAQLPVNNHNDHVGNKSEVIPMPKISTSSNDSAKLLDSAAEDDRIVQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKT9</accession>
    <name>A0A232FKT9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000087">
        <property type="protein sequence ID" value="OXU31119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKT9"/>
    <dbReference type="STRING" id="543379.A0A232FKT9"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="9">
        <location>
            <begin position="369"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="787"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="800"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="848" mass="95965" checksum="976B327B41480B57" modified="2017-10-25" version="1">MQLLIKPKTKPCKSKETKVDDLILKRKSGGSIIDQRPLFSQDGEMVYVVWKQVIRAYSAKTGDFVKELEPAKHKIISITLSPENSDTILGCTDSGEILYWNSQNGLITMKTQLLIPDKDVKIKTFHIAHYTRFKKYVCNAVITYIVKQDDAKILCVQMYDMILGTKTLYQKLKNFNEVYYIDIVGNHGENLITIAYNTFLFVLNPMWNLKFLRYKIGTDNGPDVRTITCISGHPTEECVAVGDTSGRIVLWRQLTHYDERQPVKTTFHWHTLPVTEIVFSTSGTLMYSGGGECVLVKWPLENQKKNSFLPRLPAPIRHLTVAPEKGYVAVSTLDNGILIVDAQNKLTAVIQNFTMGITSNPKSLFPAGLAVDPRTNSLVLNGRTGHVQFFNTHTKSLLYNFNITAQNLLTQERNAIIVNTEVTRVAINDDGTWMATMEERDDSVSYTEVRLKFWEFSTDKQSFILNTSIELPHEKGVNALKFRPKSLNNNQQFVITVGKDDKFKVWHLTESTSDDKKQHWKCYSVGFYRNLPALDAGFSTDGSLIGVGFDSTLTLWVPETSVLKQSLSYCLYRQPIIRVEFGKQECCHLVVVASTEHLAVWDLLSLRVKWSVSLNLTILTADPFSVYMAAFTTDNTLVVFDPGHTDPVYIRKNVVEKDVAVLAACFAPNLQDNEESSAVWQKKSQLHFLNSEQELLTLESESESNITLENLSASRNLPLTAFSRITAAEKITNTEKPASYVHDYTRLSGKGAVEELLMSVPAHALPPMRMLCMPFLLSLMGTQNNKSKQSEKFSRSNANVEEEEEELDSDEEEAVTSEAFPLSKDKVDKDAKKEEKLIHFDWDREALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKU4</accession>
    <name>A0A232FKU4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="4 15">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_002095</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4 15"/>
    <dbReference type="EMBL" id="NNAY01000066">
        <property type="protein sequence ID" value="OXU31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKU4"/>
    <dbReference type="STRING" id="543379.A0A232FKU4"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0521">NADP</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895608" description="Glucose-6-phosphate 1-dehydrogenase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="689"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="18">
        <location>
            <begin position="740"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1038" mass="119741" checksum="CB2F6C3B86637DBA" modified="2017-10-25" version="1">MTVLTTICILFTLFYAGDLARREIYPALWYLYRDGHLPRKTEIFGYARSAVTIADIRDRVAPFIQLRPQEEKLYNKFWSLNRYINGSRDADADYDRIDRIVSESEENETEANRIFYLALPPATFPSTASQIKRACMAKKGSTKVVVEKPFGRDSESSEELSEHLKALFTEEQIYRMDHFLGYEMVQNLLSLRFANRVFSSSWNKDNIAAIEIDFKENFGIEGRGGYFDSNGMIRDVTQNHLLQIVSLIAMEKPVSVDPDDIRDAKVEVLKKTRPIVLDDVVIGQYVSNPESTDPRERIGYRDDPSVKNDSITATFALTVLKIDNERWTGVPFIVRAGKGLNINRTDVIIQYKNVDHDLFDGQSQRNELVIRVGKSEALQAKLASKTPGITSDLERITIDFDYTKEYPDLQNPGAYERLLLDVFRGSQLNFVRSDELSEAWRIFTPVLHEIENRKIRPIEYNEKQLRLVAFAAKTHTKRCNSRLFFARGYSRTGFCLKKITTMDLERRLIIKELQSKESKRLMKVNTDNTIFKDSEESKKARAEGNKVFLKNTHHDDDHEEAWRLYSKSIAMAPNNSEELALAYGNRSALLVHFKKYKESILDIEKALKLTESTALKVKFYSRKAECLTALGSSENQKAWEKAKFYLSQIKDEDKDKNAVTRILNRVEKDLDNLKVVVEKVDHNPVKKSKPSEIFNSVEIKYNEKYGRHVVAKHDFAPGEIVFTEKPYLYTLNPYNNHAYCGHCLKLSWATIPCDHCCWIMFCSEECKSKAWNEYHFVECTVVPRIIYDNPEKERTPQFTMRALLKGIAETGSLDKLKKEIDDLDKCTDESKKGFSKDGQFENDKFHSVYNTTKFVPPKPRESDVKDVAKTLIFLARYTTIFGKDYKFNNGQNFTSNEDVVFVGSLLLKLAKVVGGSLCPVRDSKEWKAKCTCKTDYCSNRGEAFSIVTALVDHDCGANVRTVYTDDVNMLFYALMPVKKNEVLFKSHTFTFYNTDYQTRREPLKKILNTYCDCRACKEQWPKDMLHVHYLSVKHSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKW4</accession>
    <name>A0A232FKW4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000090">
        <property type="protein sequence ID" value="OXU31088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKW4"/>
    <dbReference type="STRING" id="543379.A0A232FKW4"/>
    <dbReference type="OrthoDB" id="7698399at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="82076" checksum="B83F866518A86334" modified="2017-10-25" version="1">MSTTDGVFLGMRKSTDAPQVGSARRAAAKKRGDFIFGASPSKSNWTRVFSSGKRQMAENMWDQTCRTCLATCGELVPIFSNDYYVRNLPDKLFHTTRIEVLKNDNLPKMICKKCIFLVDSLYCFKDQCEMAEIKLKKSLKGAADGDRTYDSYILATDHSDAVSSSDEEYHIEYASEEARLEVEKARKRNRTPKSRLSRNSGVKVKSVQVLPAESKEFCQNVDDAESSYKFQFSEIEDVNVSDSDTLYVSEESKRSVLNCMNNYDEPKYVTSEKSQFLKDKSESMKPKLKRKMDSDNNYNQLTKVPKKVMFKDTEEDLQFIEVSDNQDRMQDDYLLKETNDENNTVVQINVIENSTGKIVQNYDIPVCKETPVKNSTESLVSFEFTKKSPDENVRKILETRMKSLIRQVILDIPQVCDICTEFFDSYQDVVKHKAMIHMNMNDEYFYCPVCQDKFFSNTDLMTHIDKHKDAHSYICSLCSCSLHTEDTMRSHLLSHINLRELKCELCARRFQRIQTLLNHCDTHLRAKELTCVFCSTVLNNKESLQKHINEFHKRPAAVVESQCEVCGLRLPESEKEEHAKTHTTYPCPYCERSFSIKANLRDHVYTHLGVQPYTCLVCEKAFDSQEERTQHMQEHMKPPQKPQLQKVGDQKKFRCRVCHEILVSRAAYGQHLKEKHWNSKQTAEILRELSESCMNEKLNETLTNDSSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL02</accession>
    <name>A0A232FL02_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000079">
        <property type="protein sequence ID" value="OXU31179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL02"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7457" checksum="4390B7D3603FF800" modified="2017-10-25" version="1">MPLNNGYFSTNSKGLENSVTRHFFDVGMWFCIVLNMYNKNKLRARALTFVFFGFFNQKMAFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLL1</accession>
    <name>A0A232FLL1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLL1"/>
    <dbReference type="OrthoDB" id="6775559at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15911" checksum="218181DFF4024A58" modified="2017-10-25" version="1" fragment="single">MDLKSLEEDINSRNLKKFDICLKRAGPHNSVNCNNKGETCCVNCLYSNNKFNSQYDTKHVANDSQCCQVLINKIKKYIASTDYTKNPTFQRFISKIVSIKIPELDWQAIGRLQHLRHHYHHAAVFSQTKREPTQQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM24</accession>
    <name>A0A232FM24_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000048">
        <property type="protein sequence ID" value="OXU31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM24"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="10975" checksum="1535802C18574ADB" modified="2017-10-25" version="1">MWPDPTVRKKPVYLGGTPANKASFLFVGIGTGLIIGCCTLLSYTQYFQKRQEKHLQESIKQIENRDAKLMMMDPLVSSAVLRKLNEHNRIPDRVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM69</accession>
    <name>A0A232FM69_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000032">
        <property type="protein sequence ID" value="OXU31762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM69"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU31762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="439" mass="50755" checksum="1A6087190F83A305" modified="2017-10-25" version="1">MYKDIYTTLEPIMWVWRFVGAYPFVIRGPIGSQQYVLSTYSIMLSLIFLIVTVQYCYKSVDFINQSATEYSLFLITISVQQVSNVICFFDSVVLKLFFGKKITRSIENIAIQDKKLSKIGCSLNYSQAVRKGRLYIFILFVFLCFHIHSELVYFNGLSIGCTFNSGAPLLLRIFGNYLAMLQVANVILFAWLMFHVGLRFQVINCKIKTCIFDIEMADQNSSCLLVLRTTAKAHAQLCQAAKIINGMFVLSIVMQICTENQCVYINCVLSAFIFITTMLYYIFMELKNTLPFSHAVYYCSVILIHATTIVIIVQSCNWVHRNVRHRMTFDVLTNFLTMHLLFKAHATVKVLHEFSKENNRFDDDRHLNQIVRIGPNFLEYLKRVFHLFQIHNFSMQILHHNLTFSAWGLFPIDSTLLQSLAEAVTTYLVILIQFDPLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMK8</accession>
    <name>A0A232FMK8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_002028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000028">
        <property type="protein sequence ID" value="OXU31813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMK8"/>
    <dbReference type="STRING" id="543379.A0A232FMK8"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11781">
        <property type="entry name" value="SH3_Sorbs_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11782">
        <property type="entry name" value="SH3_Sorbs_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11780">
        <property type="entry name" value="SH3_Sorbs_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000001">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="604"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="673"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="837"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU31813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="896" mass="103327" checksum="9093D752403A4477" modified="2017-10-25" version="1">MQLSSPPPRQARKGQLPRVRELENSPEWTSLRNDIDDLRRFSRLPRRLRTRFANNSSHQRQNFERHAVQRRSMPEIQRADLVYLKLRSEEDGNMGDQMFRSEKQLNYDWKPRTEFERSYFGDIQEQPRPSSSLNYYECNDQHLLKDLDKVNKFDQNSNLIVPESRTKDALDEDYDPAEIPRRIDDFVVPHSPEFRTSRDRLHEIFEHNRYLRRKFFADMPIGANDNDNGVKPKLQIPAAVAKTTSGFGSTETLTSQSNQSAGSSTDGRKSRADFGNTPDSLDFKAAEQTQKEQLPLTYFGTDRNGGTWRSATNRPKVDDQPPQRDESPRDQPRKKQQQRKGLLSTAFPERDFRKSMPNLSSKKEEETDKYFASCARVTDSSDDSPTMDRRKNCDESNCSIERSREALLKNSRSLLELSSETTTTPARNNRRETRIERMIRRRGHGSFNKSCSDLTSIEDDSLLSPRLVGNALSASRDRLLARTKDCAVQAGSTLPSVYGPIPYKSPRRYVEGEVTIHYRSPVRAEAKEPLSEEELARRSAENMRRVYQEERRRKYLQELHDIDSRRHTDNFVSPSQKSPIPLNRYDDFVDDLSYRSRSQEQTPEPRLVARALYNFVGQSPRELTFRRGDLIFVRRQVDKNWYEGEHNAMVGLFPFNYVEIIPYDEIRTLPKKPYEGQARAKFNFIAQTNLELSLGKGELVYLTRRVDENWYEGRIAGRKGIFPVSYVEVISEPGHRPGILKSYIYIQNIRMLNLGTQRASLFLETPVQSKPVASPAAHSMLSNGSAGGKLSMGPHHYTPSLPVNINTTQPQYNSLPKGGSKLHVAPVNETLHIDTHSEPIPYRALYNYRPQNEDELELNEGDTVYVMEKCDDGWYVGSSQRTGYFGTFPGNYVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FML9</accession>
    <name>A0A232FML9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="49" mass="5782" checksum="EDF72D46371C938D" modified="2017-10-25" version="1">MTNWKISSNCLEKIQIYFLVNSKYFLFSNFFLYNXLGNLSALRALLIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMZ3</accession>
    <name>A0A232FMZ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMZ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="17201" checksum="F1B4CB86B1969EEC" modified="2017-10-25" version="1">MLPNQQHIQKEDNVSHTIKASNVVMTKTLNKRKAMSPSQVLVTKKKNGSRKPSKRHTKPDALVIKAAEGNLYADILRKIRAYPNLTVLSNSVNKIRKTVAEDLLLELRRTEDVKTQELPEAVKAALVEEATIKRLQHIVVFKIKDLDMLTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN97</accession>
    <name>A0A232FN97_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000013">
        <property type="protein sequence ID" value="OXU31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN97"/>
    <dbReference type="OrthoDB" id="7555136at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="226" mass="26199" checksum="C3833205A5A08246" modified="2017-10-25" version="1">MDEKERRLHVDNNDCMLLEFVNDSNSLAVGYLNWLKEDDLLEIQNLIKQKKEVEVMWPDCTIKTAVYMKAMLQKATFSTHVVRILDVGDWTTVQKHKTNLITYGEISPSKDRRKELKAKNIISNEKRSKKKITNSNSKDQTSLKNTSLDSVQPQVILQEILMAKESETPVERVFNISYYIGDSALYILCACSDVDIPYENNIQRSIHRCLQSFLDRSLHKIWTVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNE7</accession>
    <name>A0A232FNE7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000003">
        <property type="protein sequence ID" value="OXU32276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNE7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14118" checksum="D4FCDBDE5B234231" modified="2017-10-25" version="1" fragment="single">DNVVSNASNIHKPVKCDLSAIIIQVERLERGQVALKRARRDLDPRLAVSTSSPGIILNYDVNTAHPGHQVHREVLLSLYLCLATPKTPNQGVSTKNVETTLILPTLGTIKVLMRVLPSRYSCSATTKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNJ8</accession>
    <name>A0A232FNJ8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNJ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="40" mass="4540" checksum="1736C300834C9EC5" modified="2017-10-25" version="1">MLPTSYACLSRIASAQENLSFSSPRCLYNERVYPLEGEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNP8</accession>
    <name>A0A232FNP8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNP8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="277" mass="30355" checksum="99B0D7DA8F240ADC" modified="2017-10-25" version="1">MSRFWPYRELKTTFPQAGKATGPNPADGYDWVIALVADTGSMGLRAGQTHKVVEKSQREDLKILEGLITETIKYAKNRSNVHGPIKTGLANALKELRKIEKKGMALLKVPELRLGGESMGPRTNSMDSLANSEATVDEVRTAIGKALKNQDDSRKVTLLKLHLSGLRMAIVVLAKGQANNLLIIGHVRAVLTKPSCFLCKDAGIKENGCEHIAILGSYRVFRRALDTAKKGKMRLFEGCQDNAENKEEDKFDPESLTTLMDEGCMAMSNLKGEATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDK7</accession>
    <name>A0A232EDK7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006262">
        <property type="protein sequence ID" value="OXU16423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDK7"/>
    <dbReference type="STRING" id="543379.A0A232EDK7"/>
    <dbReference type="OrthoDB" id="7555155at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="245" mass="28959" checksum="79BF29177ACFBB92" modified="2017-10-25" version="1">MYSWWALKKATSKATINRMRAYFEKVGKPERVLSDHGTQFMSGAWRDFLSQEGVQPIYCSIPHPQANPSERVMRELGKFFRMYCSETHTAWARYLPQVNYWLNHTAHSTTKYTPYELHYGVPNKNPIRDKIKFPEELPEPYAVKVELANSRTDKVHKRQKEKQATWSRIPIKDGDLVLLRVPKQSNLLERKIAKFFHLYYGPYRVLRSFNENAYELVGMDVPQKLVGRYNRADLRVYIQPENNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEG1</accession>
    <name>A0A232EEG1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005393">
        <property type="protein sequence ID" value="OXU16702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEG1"/>
    <dbReference type="OrthoDB" id="6819627at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="79" mass="9116" checksum="773DFC7E3019DF8A" modified="2017-10-25" version="1" fragment="single">YQEKLLFIFLKPPHPKIEPFRMSRGLQLCKARTDGGSSSDKISNTILYMICKDTLPVSIVEFEGFKEWIKLLAPLYKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEN3</accession>
    <name>A0A232EEN3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_010261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005273">
        <property type="protein sequence ID" value="OXU16803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEN3"/>
    <dbReference type="STRING" id="543379.A0A232EEN3"/>
    <dbReference type="OrthoDB" id="6359065at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000056">
        <property type="entry name" value="Protein spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371186" description="Spaetzle domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="5">
        <location>
            <begin position="141"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU16803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="265" mass="29504" checksum="89D2809F309AB10D" modified="2017-10-25" version="1">MKRIVLLLFIVLVANEAEALPQLIIPVQNSSRSESGFYAQRKILSHRNFAASGDDSAGRTDAGKIIFPSDDGDFPTPQFPVRPHAGCENSTFCENTPNYPKEYLQAVLRTNKDLKFFSSDDLVLPDVLVHRVNALPDDDAPLCEATEKVVYPKVAQSKDKEWLFVVNQEGFSQGVRVETCGKENNACNLIEGFAEGYKTVCKQKYIYRQLVALSAIGQLKPEKFRFPASCCCHIKFTENPLGLRMGSSLGKKAPELPTSKANRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFT1</accession>
    <name>A0A232EFT1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004952">
        <property type="protein sequence ID" value="OXU17194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFT1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="11231" checksum="18C8DEEB4BEC131D" modified="2017-10-25" version="1">MIFKVHINSENLTYGQHCVLTDFVLFKYNYCVKSVIDALKVTNDEVFTGISISSGLHRYFNLIRCEPVTLNHQISHNHDKFMILKVDVCYFALRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGC0</accession>
    <name>A0A232EGC0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004823">
        <property type="protein sequence ID" value="OXU17368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGC0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257663" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="81" mass="8976" checksum="FCE77CA586BAD480" modified="2017-10-25" version="1">MIATATILVLLLAVIFAMEPESFDSVTSTLSSRSLRDTGITTRVTRTMTTSVPGATEDSEEMRESMQKIVDQFMTEERKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI97</accession>
    <name>A0A232EI97_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004321">
        <property type="protein sequence ID" value="OXU18052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI97"/>
    <dbReference type="STRING" id="543379.A0A232EI97"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="123"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="498"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU18052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="84204" checksum="B33E4B547992B1E3" modified="2017-10-25" version="1">MTSVFSKLIDGTSRKYGIRQEQLTRGVVGAVTALYLLKVGYPYLAASAKICIAQVKGRENALDKRSNGRVPNKQQNGTKKTAAAAKEKKIVGLDRNFLKQLLMLLKIMIPGWRTREAGLLTCATFTLLARTFLSVYVATLEGQIVKRIVLRDIKGFFWMMARWFAVAFPATFVNSSIRYLEGRLALSFRERLVEYAYKMYLSQQTYYRVSALDTRLGGAEQRLTDDLSELASSVAHLYSSLTKPLLDCALVGIALISFSARMGARTVPGPLLAVVVIALTGQVLRLASPRFGQLVAEEASRKGKLREAHARISAHAEEIAFYGGHKAEHRYLTTAYKSLIVHLRRVLALKLGYVMLEQFLMKYVWSGTGLLVIAMPLLYTSSAVLQKARNTDGDGGVSERTRYLTVSKHLLSSGADAVERLMSSYKELVALAGYTARVSEMLDVFKDARDCIYRRNVVTTCQTRTPNGTTAEDQNLVEFRDGIPIIKGVVRESEDGSISLIDVPIVTPNCEVIVSKLTLEIRPGDHIIITGPNGCGKSSLFRIISGLWPIYGGILTRPGEKYSKKSGRPSLFYIPQKPYMTVGCLRDQITYPAEVTKDECSDAKLLELLDLVDLRGLVEREPNGLDALGDWDSTLSGGEKQRLAMTRLFYHAPQYALLDECSSAVSLEAEGAMYETAKKKGITLLTITHRVSSLSKYHRLILRFDGEGGWSFGPLNSESLTFLQNGDKEEKNENKEGRYQHLQEVRDLLSDEIHIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ04</accession>
    <name>A0A232EJ04_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004117">
        <property type="protein sequence ID" value="OXU18347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ04"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="156" mass="17915" checksum="6002EE397D5930B8" modified="2017-10-25" version="1">MWILKRRDYRSRIGDVLRDMVGIIILFPSLIGYFGVRMTAFCCDTLTLYVTPLSGIRHPALARDTPPTLHMSAVHFEKAFNMDSFRELMIAMGVYHQGIDFICELPSPENGWPFLNQHHPQDNAFAATFVAETENLLKFFLHHPASNPLTEYFLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJA5</accession>
    <name>A0A232EJA5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004045">
        <property type="protein sequence ID" value="OXU18443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJA5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="223" mass="24597" checksum="5320AFDFC0E34B98" modified="2017-10-25" version="1">MRALEKSLEPLKEVPRLMNRVVVVEDDIAKLKAEQGDIKTKLDQLLSNGDGPPSSSSAVPEQYTVTIQQLREANVRIQVTGKDFIRIGHHRSFSETTSLRHLAFAALKPLDAQLAERDILSVRPLGSGRGARNETNETDGRPNAGTGASSSSIPLTASLSRTLMNSLVPVEIKLRKLHTKQLSDELLCKAQVPLPLPDSFININECLPPDVYHHRHKECCKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJH4</accession>
    <name>A0A232EJH4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_016345</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01003994">
        <property type="protein sequence ID" value="OXU18520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJH4"/>
    <dbReference type="STRING" id="543379.A0A232EJH4"/>
    <dbReference type="OrthoDB" id="5512589at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF379">
        <property type="entry name" value="HEXOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU18520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="422" mass="47016" checksum="149AAA316EC1BDCB" modified="2017-10-25" version="1">MSFISLRSRLLQGLILALIGLTFYTYYRTTASEIQQYAFVRSYNRSSFYESVHGGHANASSSDVPSTLLSKNLSDNGASSPTIVNNASHNPSPSGNLSTVITVISASSSSSSSTNAGLKLPSSTSTSTTTTTTTTTTTTVAPSTAPVIDKDSARAIYSAGHTVAIPERCPDFGKFMDLVIIIMSAPTHFEARTAIRQTWGHFGQRRDIGIVFILGSTNDPKFERNLEKEQDMYGDIIRGRFLDSYSNLTLKTISTLEWVDTYCSEVRYVLKTDDDMFINVPRLVSFINKHKRDKNVIFGKLAKKWKPVRNKSSKYYVSPAQYKPTFYPDFCTGPAYLMSSDIVHNLYEGALNETFLKLEDVFVTGIVASKLGIKRSHANEFLNRKISYSPCNVQRGISIHMVKYSEQFDLWKKLLDGKTKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJW7</accession>
    <name>A0A232EJW7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_009898</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003923">
        <property type="protein sequence ID" value="OXU18647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJW7"/>
    <dbReference type="STRING" id="543379.A0A232EJW7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU18647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58685" checksum="676CE3060E199FC6" modified="2017-10-25" version="1">MASIMLLAAYGVAALLFYASLLVLHQFTYWKRRKVLHLELVPIIGNMAPIMFRTSSFPIHSQNMYKKYPGARYYGFFDLQKPSVIIKDPDLIREIFVKSFDHFTDHDAFVTEEMDPIVGRNIFSLRGQRWKEVRNTLTPSYTAARMKMLFALVAECSKDFVQYFVDHPELAENFEAKDAITRYTNDVVASAAFGVKVNSMKDQDNEFYLHGKEFTNVSALAATKLTILQNFPNIMKFFGTTFLSNATDKFFKKLITNTVTTRIEKGITRQDMMQLLIEAMKKDDGLKVTMDDIIGQAFFFFLAGFESTSSAMCFALQELAANPDIQDRLRQEIDDEIEQHEGELTYESLANLKYLDMVMSETLRKYPPVAITNRLCNKEYTFPPLMEGYPEYQMEVGTSILISMFGLQRDPKYFPDPEKFDPERFNDKNKHKINPYTYMPFGIGPRQCIANRFALMEAKIVIIDILRKFVVKFTEKSHHPVTLSKKTFILSAEEGFWFKFEGRKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKN3</accession>
    <name>A0A232EKN3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003744">
        <property type="protein sequence ID" value="OXU18913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKN3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="68" mass="7441" checksum="3C9294346C5CBF4C" modified="2017-10-25" version="1">MNRVDYFSRDGERAATFFIGGSNDNAYLSFIFEGDDASPRGFFPASIFSIRSRKQKCGGCAGGPSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELA0</accession>
    <name>A0A232ELA0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003591">
        <property type="protein sequence ID" value="OXU19139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELA0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7364" checksum="C0534280D0A7B98C" modified="2017-10-25" version="1">MKMKKANKTIKVNFTSIRRTIMHNVETRDEFKTCSTVLKKRRYISKNCSLSFGYKKIIHPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELJ0</accession>
    <name>A0A232ELJ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003571">
        <property type="protein sequence ID" value="OXU19172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELJ0"/>
    <dbReference type="STRING" id="543379.A0A232ELJ0"/>
    <dbReference type="OrthoDB" id="10029243at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052440">
        <property type="entry name" value="Trans_Reg/Chrom_Remod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14955:SF4">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14955">
        <property type="entry name" value="RETINOIC ACID INDUCED 1/TRANSCRIPTION FACTOR 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="324" mass="35489" checksum="E7737C0C25B47A03" modified="2017-10-25" version="1">MSPSAFLFFAAGGSGGGGGSCSPVFWGTFGRKIGEVWQPPSLRLPNGVVTAGPRRSSLERNAKLFRSCGLSVILCTCCSPGPTEHSLQSVASIRNHQQSTPPPRLNRQQCARTTGQNFKCMQILNVSAYFIPGDESNISDLLLAAIAGQHKFCVTPTILSDLFGPYLIEKNWNEDSTFVNEQETAILSKGESIHAHSLEYSAVEDQLLSKWRRKKTKIHDNSKNLYMGMVTLGDDDRQWEVWLHEQCIIWTAGVFITGGRICGLQDAVWDATKSICDTCGLTGANIGCIKRGCKSVAHYCCALTSGWLLDTNHFLPKCNAHENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELJ4</accession>
    <name>A0A232ELJ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="1">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_000620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01003543">
        <property type="protein sequence ID" value="OXU19233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ELJ4"/>
    <dbReference type="OrthoDB" id="755699at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="359" mass="38896" checksum="5DC7F5E6FF7B1010" modified="2017-10-25" version="1">MAAGRLLARRTGRGCRRWCERSSGDVFDRYASTACASKNLKVAIVGATGQTGRSLALCLKQSALIDELAVYDSHPTRGLLLELSHMDSRCRTILEDEASTTSACNGKRDLERALTGAKIVAITLDGESIREEAEYLEKILSSLLGCCPKALVALVSRRVNSLVPMLYELYKRAGLFDASSRIFGVVSLFATRANGLAAETLKIEPEFTSVPVIGGGCPRSCVPLFSQTRPCADFTSEELSRLRQATKSAEAAESSSLCLGFAAARFCISLCKALRAEPGLRECAYVRSCLVPELKYXXXXXXXXXXXQLGVARISNAECQQLYLALPKIQRDIRLGESLALGLRESTELCPVPARCCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELJ6</accession>
    <name>A0A232ELJ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003559">
        <property type="protein sequence ID" value="OXU19201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELJ6"/>
    <dbReference type="STRING" id="543379.A0A232ELJ6"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000018">
        <property type="entry name" value="Phosphoribosyl pyrophosphate synthase-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="7">
        <location>
            <begin position="322"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="6">
        <location>
            <begin position="618"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1044"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1160" mass="132481" checksum="AEC56F8456186E86" modified="2017-10-25" version="1">MDRPIAVDIVIIAGNSHPELASLIADRLGVKNGGCAVYYKTNRETMVEIGDSVRGKDIYIIQTGTKDVNNNIMELLIMAYACKTSSAKSIVGVVPYLPYSKQCKMRKRGCIVSKLLAKMMCKSGLTHLITMDLHQKEIQGFFDCPVDNLRASPFLLQYIQESIPDFRNSVIVARNPGSAKKATSYAERLRLGIAVIHGEQRESESDMNDGRYSPPTLSSLRTMQVGVGVPVHPAKEKPPINVVGDVGGRIAIMVDDMVDDVQSFVAAAEVLKERGAYKIYVLATHGLLSSDAPRLIEESPIDEVRLHFYAIYLQYDKICTSLQAEDKFKRKKGLQEILKNVLNSLETKDEESSLVLWEIFHRPVVRILHDPVEACRDLALEILKKFLLHLPCSDKNIVYIIPIMAKRLGCQELVEQSEEVRLKCIILLRAIVQKYQENLISYFEDLITILTRTVTDKYPKVKKESCDCICEIARAMPSNFYTKSEVFIKPILTNISHQHYKIRMATVKTIGEVLLFGDSKLMETVAGPLAERLFDQSGAVRTAVVEVAGLWMIDLRDRYSWWYKLLPLLLTGANDIVPEIREKALSLWVKAGEQYIKENETDQKFKHKLDFLLEDLPHYPAKIIRPNLGCRTIAQQNLHKLVPAISRELNDWMADIKVRAAQLLCILVLNVEEEVTEYLPKLLSPMYRACNDEDKRVVENIELAAEYMGYFVLPRVYCDLILPSLEENPTSGHLKIFASILRGSERENLTKELSRIGHLLQENHICQSRKIRYQMEILSCCRSTLDVCKEDCSIIFHDLFIAIFTTLAISSDSLVEKSAISLLELLKKTENFENLNEIFDKHVPLILTTIQESPESWEINSSEFHIFHACIVYAKSTTYKHLHLIHPIFEKTTNSEDDKKLRLKQYILLSDYLQNWDKLLEENSANTFIEFANIVLEKMIIPGLKWAAGRTAEAIRTASVCCLCSLLSKIVDNCEESDKEKEVKTFSISVEHFGWLFETVRPILVTLLEDDANKTRLYSLQAICLVINIGQELSYITEEHIHKISPEIVSRLEDQHDEVRLAAIEALKEIWRVLPKDYDLAFYYVHIEYVYSKTLIHLDDPGEQFQKLTLDCLMALVKVHPELLIEKVENFRANFINQRALDQLVEAAQEHLKKKNSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELU0</accession>
    <name>A0A232ELU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003504">
        <property type="protein sequence ID" value="OXU19316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELU0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="140" mass="16431" checksum="518332280A1E1634" modified="2017-10-25" version="1">MKKLIAAKISNNFVKWFSGNKGGLWLDRYYMRRKYTAYYMPLVYNILMIHKHTYIYFFDNSIIENIFINLSGQPEAEIINCTTGKDELGKPSRISKQGLFKKFYHLIGKIKAIDDIDETICHNYLDAKTSVQDYSVRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELV4</accession>
    <name>A0A232ELV4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003487">
        <property type="protein sequence ID" value="OXU19343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELV4"/>
    <dbReference type="OrthoDB" id="6344725at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008726" evidence="1">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="123" mass="13909" checksum="5B2A036A41DDCC77" modified="2017-10-25" version="1">MKVCTFVLCCAALLLAVNAAEYTSRYDGVDVDRILQNGRVLGNYIKCMLDEGSCTAEGRELKKTLPDALATGCQKCNQKQKETAEKVINHLMNKRPADWDRLIKKYDPKGEFKKRFEATGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMR1</accession>
    <name>A0A232EMR1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003317">
        <property type="protein sequence ID" value="OXU19636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMR1"/>
    <dbReference type="OrthoDB" id="7446692at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21403" checksum="01101DAD51BFB197" modified="2017-10-25" version="1">MMLVLVQQNKKSEPMKRLALGSSLFMRDCKIMHEHVHVCVNISDFRALRRSFFRHKGLHLIKSALIVAPHGYILDNHGLYFSDAQNNDAAMLQNEWNSDEDLNNWFQKGDIFVVDRGYRDIISVLKNFGLVRKMSLLLEAGEYQLTTEDANEALNGHLKSKFKYLGLFNRFTFFEILSGRNKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENG1</accession>
    <name>A0A232ENG1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_009161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003159">
        <property type="protein sequence ID" value="OXU19890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENG1"/>
    <dbReference type="STRING" id="543379.A0A232ENG1"/>
    <dbReference type="OrthoDB" id="5318at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="211"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="592" mass="65859" checksum="6982908955751DD0" modified="2017-10-25" version="1">MSGQNESRSTPERRVLGELGNSNPDSPTANLRLLTNLASSLKSATDSPHQGSSSSGTATQLVPVQNTSNVRLLPRKEKSLSLLCNKFLDLFPLNIQENSLKEISLNTTAQALGTEKRRIYDIINVLESLEMATKAGKNLYKWHGQSRLPSTLAKLKMSAIDLGLEKHIQDIQKFNRAYVEDSYQSNCNTSDDLMVPQSPTVNYCFPGNPTKEEKSLGIMCRKFVMLFLVSLKNGVINLDIAAKVLINEEDNSTDIKSSAAKSRYKTKVRRLYDIANVLSAIGLIKKVDLYNCVIRKPIFKYTGPSVDCLNFDAETSSTENGSQSLVGMTTPSKKASDTFSFRTLSRISRFLANTPITSKREPKKRKLFDSDTKFERTQSSPCLSTGKARISDRLDDSILQVAEMELKRIKSSEHKPKVRTNLFPRHNSDSLIPPLKLEFDMTNAEELPNVASTSTDKSITMSDAPTVLPVVSKENLVNESQKVITPIPTVRIVVPPNVNRASFPLSKCGTPKFMKLTKLDMKKLVPISKEDIRLRLSSVNESPNLMHKPNIAIVTQIPNNRISPGDTFKAIEVDNTLKLVLIKQKGDNEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP81</accession>
    <name>A0A232EP81_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002987">
        <property type="protein sequence ID" value="OXU20170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP81"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6967" checksum="106C353EEA40AD28" modified="2017-10-25" version="1" fragment="single">SGLQNPWSKLPTGSWQSRNDYKTTPNRIGLKPRIALSIRAYESQMTKKRSLILLIGRIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPN5</accession>
    <name>A0A232EPN5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_013928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002921">
        <property type="protein sequence ID" value="OXU20292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPN5"/>
    <dbReference type="STRING" id="543379.A0A232EPN5"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="386" mass="45232" checksum="2F16EAA257421A8B" modified="2017-10-25" version="1">MIRRNRQKLLHIFKTKHKVYFIGLLLGITVLYNEFLAYEIQAFKWSLRKCTDCVTVLLIADPQILGYQNENYKGSAWAMWDSDRYLKKTFSRAVSRTQPDVIVFLGDLMDEGHIANAEDFEKYKRRLAHIFDTPDHIMKIYLPGDNDIGGEEDMVSSHIHERFNYAYTQSDTLVYSTATFFKVNRLTKTIPAAPKEAFLNDYAERNTTNVVLSHMPLLFMPGTFVQNVLKELSPQIIFTAHEHKAMHMSLDTATDQLSEIWILPPHKTPLYQLRLDMGDIHEIQIPTCSYRMGTPNMGYGLAYIDTQEKTLDFTILWLPERFYQIWLYLYVLVVCLFRNCIKLEPREFRLAPESQLDVNMKICQLVKTWKHLDLDKFIISVKIFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ98</accession>
    <name>A0A232EQ98_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002808">
        <property type="protein sequence ID" value="OXU20534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ98"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8986" checksum="017BAC3BD33EF005" modified="2017-10-25" version="1" fragment="single">GCVCVCVCGYVCVCVYVYCNISGTTRSISIKFDMHVYFLILRKTFIFHFYNYFLFYGQFLIFEKHYFAFFFNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERL9</accession>
    <name>A0A232ERL9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002572">
        <property type="protein sequence ID" value="OXU21023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERL9"/>
    <dbReference type="STRING" id="543379.A0A232ERL9"/>
    <dbReference type="OrthoDB" id="7550800at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14561" checksum="29A5B0F6A7876714" modified="2017-10-25" version="1">MLSTRRLKAEWGSSSKDGEVGIYAQAYADDIVLMVTGDDESVIAGIMQYALGLVEEWCKEVELGVNPNKVSTMLFTKRYKTKLMDGITLNGVNLKLVKDTKYLGVVLDPKLYYWDKHIKIKCEKTVSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESM0</accession>
    <name>A0A232ESM0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002398">
        <property type="protein sequence ID" value="OXU21355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESM0"/>
    <dbReference type="STRING" id="543379.A0A232ESM0"/>
    <dbReference type="OrthoDB" id="7699407at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="355" mass="39020" checksum="3CB4EE1CAA2BCE77" modified="2017-10-25" version="1" fragment="single">MATNYSVSAFWREKLVLWFMQTEAMFEKHKVTDDTAKFNTVVGALDVSTIDDLQDVIRNPPANNTKCATLKGTIIKRTTESPDNNLLKMLTNLELGDSKPSQHWRKMKSLADRKILEPALKVMWLAHLPAPAQTYLSVFKIENVEDLLEATNKIITRNKQVTAVTAIGDTSNASSGYGTPVSAIAPEQQQLAAIQTAIAQLSVLTSHSRGRRDRGKQTMARDTREAELAATPARGDARQQAAKTTAETPTHTTYIGHSISTYGTQRLKLSLGLRRNFTCNVIIADVPHTILGANFLIQHGLVVDVKSRSIRNKGALASRYDALLEEFADVFDNAICPTCTLGLLVKHVINTNGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESV2</accession>
    <name>A0A232ESV2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000028</name>
        <name evidence="3" type="ORF">TSAR_000029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002373">
        <property type="protein sequence ID" value="OXU21430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01002373">
        <property type="protein sequence ID" value="OXU21431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESV2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="43" mass="5155" checksum="44D6B8725389644B" modified="2017-10-25" version="1">MRWRPWRDDRASALQARGSRFKPGVSYFFVALFTHNIFWGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETD5</accession>
    <name>A0A232ETD5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAP kinase-activating death domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_015555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MADD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002289">
        <property type="protein sequence ID" value="OXU21613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ETD5"/>
    <dbReference type="OrthoDB" id="6282239at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000002">
        <property type="entry name" value="MAP kinase-activating death domain protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056574">
        <property type="entry name" value="Death_MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039980">
        <property type="entry name" value="MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057469">
        <property type="entry name" value="PH_MADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008:SF7">
        <property type="entry name" value="MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13008">
        <property type="entry name" value="MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23629">
        <property type="entry name" value="Death_MADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25328">
        <property type="entry name" value="PH_MADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="11">
        <location>
            <begin position="1"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="701"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="850"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="956"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1186"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1186"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU21613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1549" mass="172477" checksum="6A2ADD55A9369303" modified="2017-10-25" version="1" fragment="single">MYVQVPELLRRYPVEDHKDFPLPPDMVYFCQPEGCSSVGPKRTALRDSTSFTFTLTDKDSGAYIAIYAYTYYIPSKKMAENILNFRREEFLFYRGYCKTRYGICVNFYRPVERTGGNGAAGIGFRRDKQNTNFRRESWRKSMEKSSDSAFSSDYRSSALGPSDSEKDCPSSRRDSDTPHGVASGLXXXXXXXAPRLGITAPSADSESGGSHSPSPRASRRRQRIRNHSLTSLCIISHHPFFSTFRECLFVLKRLIDACNESTLPQKVGASRQHRDNNVWSVLSGQTLEGASSIVLHDVREIETWILRLLSAPVPVPSKTRVEVEILSPSLQPPLCFALPDHTRFSLVDFPLHLPLELLGVDMCLKVLTLILLEHKILLQSRDYNALSMSVMAFVTMIYPLEYMFPAIPLLPTCMSCAEQLLLAPTPFVIGIPASFLLYKKNFRIPDDIWLVDLDSNKISPPTGHGCDILPPLPEPEVSILKNHLSQMGSAPPSQKGSPQSNNPGVFNPFIYGNDVDSVDVATRVAMVRFFNSQNLLANFTEHTRTLRLYPRPVVAFQINSFLRSRPRTSQFLDRFARTQAVEFLAEWSLTPSNVAFLRVQTGVYDPAQIGDKAKWFAPSLEPINFPVWDNGSSLANALKAMQEMESQPTDESGSDSEDAESTSSSYSSLSDFVSEMASSDLSPLTHPPPMSLSIDAKKIYNPPSSLQYPGVEEESQARAESPPSTSSSHSDLSSPSFNRDSEVELAAKLAENSQTAKSDNLKHHAKEKISEAGEDSLFAPLEQLTQQTKKAMGEASKSVQEASKTALEASKTAAGVSKNTLDDLTYVGKSTFGDLTKSAKEAAAKKGLLKSLGDSQQSPPHSPPSGMLQRKDSGSQLVTPDARTGRREIGRDFFSNISSDLNGIAEQTSSMFSGFFGSKNNANKNATVLPHSQKSKEKSQLFGPFSKGRTSLVERTSLIKHSSNKANQEELRRQQNADRTNTNTDNQAFLTDVINQVMTGEGVGWLKFNRLKKLMEDESYRDFMVTKLNKGLNRKISPDDHIDDVCITKPVYKGMLKCLQAVAHGLDVTYWNFGLGGLASVFQMMEIAHTHYWSKDLLESGFDSSLMSQASSPFGSRENLASPQSPNHPAYDPSQKSYSQEPPQVRLERPQSQTSSDDNQSTTEMFLDMFTMKNKKFLLSKLTSFDSDSKSGNTAGSNEALSTDGGSITTNPAFRGTHQASFRSTVSDSEVEQGNFPRQKQRTASVWSSSRSSLGKFSAAGNVLIPSTTSPSPEMARTYLFVGLLGKERSLLWDQMQFWEDAFLDAVSQERDMIGMDQGPGEMMERYKSLSDSERRRLEHDEDRLLCTLLHNLTAILVMLNVEKKDVGQKVRRLLGKSHIGLIYSQELNQLLDQIKDLQGNDIDLKPLTSRQMHRQSFTVHAGTNAEGDLRFLEVRHDGLVLRSVNGVIVERWWYERLVNMTYSPQTKVLCLWRRNGGQTQLHKYYTKKCKDLYYCIKDAMEKAAARGRGANMDVELGGEFPVQDMVTNQGGLLQVCMEGIGLLFANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU63</accession>
    <name>A0A232EU63_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Charged multivesicular body protein 2a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002172">
        <property type="protein sequence ID" value="OXU21874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU63"/>
    <dbReference type="SMR" id="A0A232EU63"/>
    <dbReference type="STRING" id="543379.A0A232EU63"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU21874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25875" checksum="9B48F3A7C3A04F07" modified="2017-10-25" version="1">MEWLFGKRVTPEEMLRKNQRALNKAMRDLDRERMRMEQQEKKIIQDIKKMAKDGQMDAVKIMAKDLVRTRRYVKKFMLMKANIQAVSLKIQTLRSQNTMAQAMKGVTKAMQNMNKQLNLPQIQKILQEFEKQSEIMDMKEEIMNDAIDDAMEDEGDEEESDQIVSQVLDELGLQLNDQLSGLPQASGSLSIASSKQPVAAAAGASDGDGNLADADADLQARLENLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUI4</accession>
    <name>A0A232EUI4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_014107</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01002121">
        <property type="protein sequence ID" value="OXU22023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUI4"/>
    <dbReference type="STRING" id="543379.A0A232EUI4"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000171">
        <property type="entry name" value="inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="16">
        <location>
            <begin position="310"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU22023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="522" mass="57858" checksum="861E8785F199DB76" modified="2017-10-25" version="1">MSSLKIHVDSPRVEYTAEAILAECDYQTTKVARAGDDSAPAYEVVPESTKLLIKTDIKVPKLGVMLVGWGGNNGTTITAALLANKLKLSWETKDGVKRANWYGSLIEASTVRLGSDGVEDVYVPISWMLPMVNPDDIELDGWDISDMNLADAMERAKVLDINLQKQLRSHMRGLKPRKSLYFPDFIAANQESRANNLISGTKKQQLEAIRKDIRDFKASKKLDKVIVLWTANTERFADILPGVNDTADNLLKSIDESHPEISPSTVFAVASALEGCTYLNGSPQNTFVPGAIELAERLNTFIGGDDFKSGQTKIKSVLVDFLVSAGIKPVSIVSYNHLGNNDGYNLSAPQQFRSKEISKSNVVDDMVQSNKVLYKDGEKPDHCVVIKYVPYVGDSKRAMDEYTSEILLNGHNTIVVHNTCEDSLLASPIILDLVLLSEICSRMSFKRAEQPDSEYRCFRSVLSILSYLLKAPLVPQGTPVVNALFKQRCAIENVLKACVGIPPENHMLLEHKVDILRKYRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUN3</accession>
    <name>A0A232EUN3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_000538</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002120">
        <property type="protein sequence ID" value="OXU22026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUN3"/>
    <dbReference type="STRING" id="543379.A0A232EUN3"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012421006" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="67"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU22026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="307" mass="33660" checksum="B8FC0280192B6A57" modified="2017-10-25" version="1">MYMKILPLLLLSLSASLNIAEALPKPKASYFNFTHVSDDGSFYASYHGNDKNHQYVDKGDENHSDKIYGGSNAALGQFPFMVIIHRLAGKGQYFVCGGSILSSRWVLTAGHCIANKPQKFFVVFGVVDKSGFGYDYITGDGVSMISTQGALHPGYGEGQHDIGLLYMPKNIPFSDTVQPIRLAGKSYQRQSFASQMGHIYGWGKDEQDGRAISKLKYGRVPIISNGMCRRTWNVDYTHVCTDSSTGQDVCQGDSGGPLVVLEEDDEPLQVGIVSYGDAGCPSSRPSVFTRVSAYTTWIKRVTGIDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUN8</accession>
    <name>A0A232EUN8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002109">
        <property type="protein sequence ID" value="OXU22054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUN8"/>
    <dbReference type="STRING" id="543379.A0A232EUN8"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="167" mass="17385" checksum="673EF4912082BBCD" modified="2017-10-25" version="1">MANMIRCGVGIFTVKHAKQVVPRVLLPARYQRLCFHTSWILDVKGKELLMPALSPTMENGIIVKWLKKEGDPITAGDAIADIQTDKAVMTLEFDDESVLAKIIVPEGNNAKVGDLIALTVEADEDWKSVEMPSGAAAPSGGAPAASASAPSPAAAASGPAAEPPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVE6</accession>
    <name>A0A232EVE6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_007039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002019">
        <property type="protein sequence ID" value="OXU22295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVE6"/>
    <dbReference type="STRING" id="543379.A0A232EVE6"/>
    <dbReference type="OrthoDB" id="7693672at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF14">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012985980" description="NADP-dependent oxidoreductase domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU22295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="332" mass="37515" checksum="DCD19D43707B9D8D" modified="2017-10-25" version="1">MTLFIGSVCLLLITEVCQGSIIPTFELSNGNRIPAIGLGTFLLSGEQVDPAITAALENGYRYIDAAFLYNNEPEIGKALKKWLDNGGNREDLFLLSKLPISAMRPSDVTEALELTLKNLGVDYLDMYLIHVPAGIYRTADYQMLVYDNGTYAIDNSTDLLAVWKELEKQVKSGKVKSLGFSNVNKNQILRIWENSEIKPSNLQIEINPYMRQEELINLGHKLGMVVTAESPLGSPSFEYMRRKRDLAKLPPVIGHPIVQSIAKKHNKTPAQILLRYNLQRNVVVIPKSSHPERIKENLDVFDFMLTKIDMALLTTLDKRGRYRKYNFLTLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVF8</accession>
    <name>A0A232EVF8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002001">
        <property type="protein sequence ID" value="OXU22346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVF8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="23" mass="2519" checksum="40046ABE2A0FF179" modified="2017-10-25" version="1">MSTLLVRVKDDCKAYASILCGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVW0</accession>
    <name>A0A232EVW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001945">
        <property type="protein sequence ID" value="OXU22484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVW0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51867" checksum="25A9B957DD321BC9" modified="2017-10-25" version="1">MPIIWKSPKVDKRRSTPCYRFQATRSVGFRKDDHVKITQSHRDDNADYEGPYPAAEYYAPDTMSSKKCEIFFNWHNEVSITEKFNMRREIVSYCIHDVTVLRLACVKFRQIFLDCVNLCPFTKNVTLAGSLAYACNFLKDNLIGLISNEGYVRVDRHSQKAVEWLLWVEQQLKQESSGWPRERVLSYDTDSIIYVSKGERDEYEPETGTLLGQLTDELEECGEGSYIETFVPGGPKFYAYRVRAPNGETFDRCKGNTIIAVEIMGIWLRGVIEERCPQRCRLTDNGTCVTLIESNEESGIYLLKVRFLVLPSRAILADLSHDHLTKTPTTAKQNSITSAGVAVTDVVILLMLLLTLILRGTTDDPDDDDDDNDERTLNVLSCADGFFVLTGSAGLAAYKPQVSLSFLRIVVRGGVLPSKSSSRLRIHIASCEASARAIYSTSVDDNATHVCFLHAQLIDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW07</accession>
    <name>A0A232EW07_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001926">
        <property type="protein sequence ID" value="OXU22540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW07"/>
    <dbReference type="STRING" id="543379.A0A232EW07"/>
    <dbReference type="OrthoDB" id="360585at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="170"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="479" mass="54290" checksum="AE12973DA9A7BF23" modified="2017-10-25" version="1">MTETQGNTQENSFNERILQFNLKNGYCLRRRAHNYATIYESNDSKNVGKKAKVQGWVKALRKMKDNIFLDINDGTSSQPLQVVLKKSMKPENLSYGCSITVEGEITVAPNGRAELQVDKIDILGKCDLEGYPFLPRKQYSEDYIRRYLHLRPRTKAFSSTMRLRDLATNAIRDHFRDRGFINIHTPILTSNDCEGAGEVFIIQPNSQKLVQAMKTEGVDVESTYFNSKAFLTVSGQLHLEACARALSKVYNFSPAFRAENTKSRLHLSEFYMIEAEMAFIASLKDLATEAELLVKSVTFSLIEKGSSDLQVLEAPEPTWLNKDFGYITYTEALDILDKNSDRLTFPIKPGEGLAKEHELFLVHHLGDVPVFVTEWPVNSKPFYMKECEDDKSKVQAMDLLAPTVGELIGGSVREDNYSKLKSKIPPGLNLDWYLELRKFGNVPTAGFGMGFERYLQLISGVPNIKDVIPFPRWPHNCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW60</accession>
    <name>A0A232EW60_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001910">
        <property type="protein sequence ID" value="OXU22588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW60"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="57" mass="6690" checksum="B1275AD47FF97105" modified="2017-10-25" version="1">MRCAALTTALLREGVASSATRFFRSDGFLGNIRTLFLLFFVSRILRHRVMRKRRKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW99</accession>
    <name>A0A232EW99_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001901">
        <property type="protein sequence ID" value="OXU22613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW99"/>
    <dbReference type="STRING" id="543379.A0A232EW99"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF57">
        <property type="entry name" value="METALLOPHOS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="3">
        <location>
            <begin position="75"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="247" mass="27829" checksum="12C24D91817D3878" modified="2017-10-25" version="1">MVLDKARKEDKTVYIVGHTPPGIDDRESGSGVLAEEHNTRYLQTVRQYSDMIRGQFFGHWHSDTFRVIYSDNGEPVSWVMVAPSVTPYRAGGPNNPGLRLYKFDNDTGQVLDYAQYYLNLPEANLGKRANWRLEYNLRDYYELSEITALSLHDLADRFTQSSDNKFVRYYGANRVALPREVEEIWGCGGALNGLCALQHYCKVTRLTQRAYSNCVSSYAYALAAAASSALGPRLMGLLLPALLLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWE1</accession>
    <name>A0A232EWE1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001875">
        <property type="protein sequence ID" value="OXU22669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWE1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="9967" checksum="70A392021FFC8D46" modified="2017-10-25" version="1" fragment="single">KITPVLNFTLSGDSKNSNKRSIPKFDRDCQRTKASENGAINHLSVSLLLTSPYNADPRLPQRDFARVLMAYYAVVPFLGPSVSKVGMLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWE6</accession>
    <name>A0A232EWE6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001870">
        <property type="protein sequence ID" value="OXU22678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWE6"/>
    <dbReference type="STRING" id="543379.A0A232EWE6"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01167">
        <property type="entry name" value="INSADHFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31273" checksum="4420A51B5382BE47" modified="2017-10-25" version="1">MSRQGEYKDIKDKVIIVTGGANGIGLECVLEFLEKGARYVAIFDITPENFTADKLQEEFGTHRVDLYHCDIANEEEFRSNFKKVIEKYNYVDILINDAGVANENDTARLLDVNVKGTILGNLIAIEHMGKHKGGRGGVVVNVASVIGLLNCHVLPVYSASKHAIVSFTRSMKSNYDRIGVKIIAVCPGHTRTKLNFELAVETSVNYLDFIPQESIDKFNKSKLQYPDNVSDAIMDLITDAEPGTVWVVENDEPHFKISSSDHYTKKIIDNHEAKVFFCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWW3</accession>
    <name>A0A232EWW3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001816">
        <property type="protein sequence ID" value="OXU22838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EWW3"/>
    <dbReference type="OrthoDB" id="9989103at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF72">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="301"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="491"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1779"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="1972"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="2200"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2393"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2393"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2405"/>
            <end position="2424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2424" mass="274692" checksum="52B4F76ADBB5D432" modified="2017-10-25" version="1">MVVENEQFVFVVTHVEAEGQFLKIWAQTDERVVQSVASMLTPLQEKLDYSGASNFLSPNNVQPHTRCCAKGISKEWARAKILNLRSDGMILLQFVDYGNIIYVPIHNIRLLDNMPEANYLFAVPEAATPFVLADVIPIGGSWMDEIVNKIRCILINNKYHGVYQTVNNYKALKFDMMSKDFSRTLIERNMALYSPSCPSNMQQMMPAISVQPLRTPHSANNMHQENWRTSVPQNVAPVQKVVKTNSFKAIQLEIGSVHDVRISYVEEGPCKFSVQLLESIPYLNTLMEKINSQSHLPLQEPPIAGTVCLGRQNHNNRLCRVVLNSPGDTSCKVYYADYGHHEVLQFSNIYQIPDEFVIPNIFSIRFTLSGIINWTVTPEMKDYFGGLVSNENLKLRVCKGPMSPLTQYCELYLRGKNIKDMLSETFPDSCEFVYNEPKRLQEGTKEMVFVSFVQSVTKFFIQIERDLKFLDDVMDRIELISKTAAKVNPAKIHPEMPCIALYDLDKKWYRASIIGMTDNDKARVFYVDYGNEEIVSVQNLRVIPADLVRVLPKQAIRCSLNGFKPAGPLDKEFTKTFENLVIEERLCLIVLNNLPNTVIVDLFEGQNASNNLSTQDIAAKLKALEISTKPENVIPTDRQIDRSVEPRTLQSRNQKSDAKAQAPSTQKQKIKNKNTKTRDNGTARWEKETNQAQFSKPNSFEPYDTSKSKFRKDNENEQRNDNRFRKGSSEYSNGSQSNRFDKELAKPDRFSQNDRFGNKSNDTHRPTGSINDRLNRNRNINFENNDFRAGKVGKENSDSRPSINSRLDRSFNSDKAGSDKDSDTSSRSGGRRSNRGARRSTEDSRKRDAPANNRNRIGRWESEEREVSLKNYNGDTSLSPAKSRSPRDNHVRDNFDKSKSSEWDASSKLSTSCSKDSSRYMTSTPISKIPPPNITIGAVKNCVLVYYTNPVNFYVHLLPDIKDLNLIMEKIASIYEDGGKVLQQSEIRPDLQCIAQYAEDQQWYRAIVKSVEATSATVHFIDYGNDETISFDKIKEIEPEFLKLPAQAVHCKLFCPSKSTYTKEESDKFADTADGLELESEFVSEENGIYQVLLGEPNSKNVGSAKFINNMFADGQDLIKEKEAARNKSRTIMQTERSTPNYATLDEKWSENKLDLGIRYPVLMGWFINPESFYCQLADMQKEFRDMMNEIQNVYAKRQPVSGQLKVGSSVIAVLPEDGVLYRAQVLELNKPRGHVVQYIDYGDRAMVDPRNIYPVERKYMKLPKQAIFCALKNIAPTPGSNWSNTAELAKLFGAEKFDCIFHELKNDKYLISLSSNGIDIGSALVDKNVAVFSTAIDKQTESLPEETVAVPEELRMDINLLEGQTLHVRVSSVEGVAKFYVQLYTAVACQSAIDNYMASKDPQVMPRLLCHEVCLGAGCLVNCRGKWRRGVVINFTKSNYEVRLIDTGEHETISLKSMLGLPGQLALMQNQAIECALFDVPLSSKADNSLKKLVTGKDVKIFVEKVERNRLIVRLFDINGTKIKVFDTQNTERISPVCSMQILGSRHEVNVSCIRNSNNIWLQRTAETSTEKQLSKSLTDHYSTTNDQIIPKENEVYAGLCTNGSWNRVQVTKLNGNTCTVTRIDNGHVQDISIDKLRALDAKFYLPHQLAIRVSLPVSLTGSDVEQINILEPLLVNKVLTATFFNVNRKWVVELSENGEKLSEKLSSLNIVKETKKTRFDHVELPGMVVGQKYEVIVAHSLSPKQVWLQRAEELDAILDMQDQLQEASTDYPDYDGIPEEKALCLAMYSLDDLWYRAEVLDADEEITTVRFIDYGNTDVIHNNVSKIKQLPDKWKAIKKYAIECKLDVLPVNADDWSDEASAKLSELVTTEDPIHALIIADKAPMRIDLYRKGDSICKMLIDEKLATYVQSSEDLNEEIVEEVQLDPRSAFVSNIISVDQFWVQEEKWINDLEMIEDRLVMAPMFPQVPEIEEGLICIAHFPDDNLYYRAIILSHTDEGTKVRYIDYGNSAITKDLKTIPEDLAQIRPLSRKCCLVKPDGIEQWPDGIHDEFVTLAASGATVFLLDVIEESETCLVKLTCKDKDVAMELIEQCSNRSDPEAKATEVTEEIKVAKVSNENKIVDTEAIQNEVIKNVKDIITVERPPPIGEENSEKELVCTISYVNSPADFWVQNKEHFTDLDNMIDQLVNAENYDSIKEIKEGRIVAAKFDEDEQWYRSKILYHSETGTEVFYIDYGNSAVAKSDSSLRELPGELAQIPPLSVQCSLKLPDGLESWSRNACEKFCDLAADGVTEFKFEILDENNQKSTNQPLIISLIYKDQDVAEILANHEKTLQSVTESVENEKVEFELRKPKDIDSTGDSAIQSMQSEIEETTFEIERTTVQVLHDTRLCNSSSMGNSSKNEATDVSKLNKDTELKADELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWX3</accession>
    <name>A0A232EWX3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001817">
        <property type="protein sequence ID" value="OXU22831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWX3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="32" mass="3748" checksum="11BA4E30FB30DFD7" modified="2017-10-25" version="1">MNVHQFFHLARSFLSHIMHTSSLSLSLSLKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXP0</accession>
    <name>A0A232EXP0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001724">
        <property type="protein sequence ID" value="OXU23115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXP0"/>
    <dbReference type="STRING" id="543379.A0A232EXP0"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartic peptidase DDI1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="167" mass="18786" checksum="329EA3883A2C0D70" modified="2017-10-25" version="1">MMLRCEEADSTSYWVNRMNGAQTTIMSAQCAERCNIMRLVDIRWSGVAKGVGVQRIIGRIHMVQIQIGCDHLTTSFSVLEEQPMDMLLGLDMLKRHQCCIDLKRNILKIGTTGTETSFLAEVPLVQQQVIKNSVQVCNGTASSLIEWPQSVGQGNLENKYDLYMIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY34</accession>
    <name>A0A232EY34_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001628">
        <property type="protein sequence ID" value="OXU23386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY34"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="71" mass="8050" checksum="50ED83E5A2106009" modified="2017-10-25" version="1" fragment="single">CIFCYPVRLGFLILRVSAEARGGFTVLTERALLADIAPMRPSRKPGSLLYQQNHRACRHSRVLLGTMARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYD4</accession>
    <name>A0A232EYD4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001610">
        <property type="protein sequence ID" value="OXU23434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYD4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012150020" evidence="3">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="14984" checksum="5A244E001401C3CD" modified="2017-10-25" version="1">MASLKCFVPLMFCVLLATLCIASVKPIGEESDKKSIKTALSDEAIKAKLTAQLEEMEKDVDDFRKLAFDISHRNKLVKDFVSFELEILVKKIDELDSELDEITAIPDIQKGESETATEHIAKKPEEQNSTEPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYH4</accession>
    <name>A0A232EYH4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_002181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001620">
        <property type="protein sequence ID" value="OXU23411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYH4"/>
    <dbReference type="STRING" id="543379.A0A232EYH4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895598" description="Partial AB-hydrolase lipase domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="461"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="865"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1234" mass="138623" checksum="494D774D5843DD89" modified="2017-10-25" version="1">MCYKIMILVIYLVLIISPLGSKSQVLTTFLRPLSLMLNRNGANVTQPYDTKPLILNFIGLVTRHGYPAEEHQVTTEDGYKLRIHRIPGSPKSFPAAGKPVVFLQHGLFSSSDIFVLHGPNRDLPFLLADNGYDVWIGNSRGNTYSRAHVRLFPDKDPEFWYFSFQEIALYDASATIDFILYSTREKSLVFIGYSVGATVGLALLSTKPEYNNKVRLFVSLGPTTYWRRPKGVVRWLRTHGAGIKRAFVRAGRNEIFPQQAVGSFFDTMCGDKSPFSSLCGLIVERVVTIDSKVMNKTELAYVFSHFPAGASTRTLFHCYQNLVSGKFQMYDYGEEENLKIYGQRAAPVFDLGHVTAPTVLIYGRADIIATPEDTKELARNLPNVVLVDGVPSEKFNHLDFLLSANAKSLLYDRIIEIVQHVLIGCGCGQSRIGFLDFIRPLSIRREKDPNGKLPVLDFIGLVTRHGYPAEEHQVTTTDGYRLGLHRIPGSPKSPPGPGKLVVLIHHGILCSSDDFVLAGPDRDLGYILADAGYDVWFANVRGNTYSRSHVRLSPDHDPEFWKFSMHEMALYDTSRTIDYILGQTGQQSLIIVAHSMGTSISMILLSTRPEYNAKVRLAVFMGSVGFWKRPRNVMQFLKDYAKFLLSLARVLRLREFLPQTLATGELMSGSCRDGSPFQHLCISMTEYLSGYDPDLLDTKLLAEAYNYFPAGVSAQTLSHFHQNIKAGRMQMYDYGLVGNVQRYGQTTPPVYSLENIDIPVVLIYGNGDVIASPEDSLDLGTRLRFSRVEMVPHDRFSHFDFMWAKDIKRLLQDRVMQIIETADKYGSYSSRIGFLDYVRPLSIRREEDPNGAMGKLPVLDFLGLVTRHGYPAEQHQVITTDGYRLRLHRVPGSPKSPPGPGKPVVLIHHGILASSDAWILAGPDRDLVYILADAGYDVWLANARGNTYSRSHVHLSPDHDPEFWKFSMHEIALYDASRAIDFILERTSQQSLIIAAHSMGTTVTMILLSSRPEYNAKIRLAIFMGGVGSWKHPRNFIKLIKENGQLVQSVIRALQIMEFLPQTLATGELLNATCRDGSPFQHLCTSLTQFFVGYDPDLLDTKLLAEAYSYLPAGVSAQTLTHNYQNIKAGKLQMYDHGPVGNVEHYGQNTPPLYNLENIVIPVVLIYGNGDTIASPEDSLDLANRLRYARAEMVPHDGFNHFDFLWAKDIKRLLQDRIMQLIESAEKYGSFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYI4</accession>
    <name>A0A232EYI4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001592">
        <property type="protein sequence ID" value="OXU23492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYI4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="13276" checksum="0C0ECD685F1893C9" modified="2017-10-25" version="1">MLSSAQKDISAKLAKPYLSPYIISKRIGKNVYSKRAKKSPKRTLRKLATPRPPKNSSADPTNRVNKTRSCLFPPPSTVRHYRYVRTLTTIGDSSPATHRKRKRKQRNFPSSLHSADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYJ0</accession>
    <name>A0A232EYJ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001636">
        <property type="protein sequence ID" value="OXU23360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYJ0"/>
    <dbReference type="STRING" id="543379.A0A232EYJ0"/>
    <dbReference type="OrthoDB" id="7616348at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="433" mass="48315" checksum="F6723FAB78D6C056" modified="2017-10-25" version="1">MFSRAAKSIVQSLNQRSYHVSKGNFKAAIGSTGEVGTARFSQQPTLDSSAVQEIVPFKNLKFKNITSNSAEGQTRSGVGVRAVKGTAAEGNVHAIDLAQAAAVGDLRKSLLKFLQNDAKSFEKKSETLARKFLQPQIILFELFMKFYETLFENTNKRAYIAIFERLKEQHSVMSSKVVEFSLHLRRMNVVKKEKVEELKAKIKEIMQRINRKLGELKTLKEKHKKRLEADAKTKKDTEKQERKTNRKESSDETPKKQIEEKERPIEAKKEVQEEQKIKAAVAKNKTSSTADCGESKCPPVFRAPGCPPKSSNSLRGLGPIIGNPNGAPGFYKVPMKASGDFGDHVRNDDYFPQGEEYEDEIGSEGFIRPSEGLRLGSSDCGVPPIRRKKNPCDPPEGPCKPLPPPGYPSKPKPERKPFCVKCPPKKPCPENNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZM0</accession>
    <name>A0A232EZM0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001557">
        <property type="protein sequence ID" value="OXU23608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZM0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="20129" checksum="8BA7EDB0E9451038" modified="2017-10-25" version="1">MSTCTLRWSPPKNSRDIIPAIKHLPHRLYDTCSRRRSRLGPPYTRYTQDSCTRLIPRSGIKSQMMMTMMKGAYLYEVGKKQDVGGGRPHGFPRESRDYRITTRRMLHSRPAQHCRPEQVHSLAVSASMSCGNTRYRSSGHSNLLFIKIIQYTLFRLALSSRLELGKSAAHLYDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F079</accession>
    <name>A0A232F079_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_012745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001451">
        <property type="protein sequence ID" value="OXU23940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F079"/>
    <dbReference type="STRING" id="543379.A0A232F079"/>
    <dbReference type="OrthoDB" id="550309at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042376">
        <property type="entry name" value="MED26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201">
        <property type="entry name" value="CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="529" mass="59086" checksum="7DF0A8E0DE7AFFEA" modified="2017-10-25" version="1">MQRHCTELTERLLQSLDEEYNVVDMGVVVDVITALEKTTITKEVLEITRLGRYVNELRRKTHNQVLAKRAKELVRRWRNALVPSANATPQPPVADTAPPALNGANAPSPALRCLEPQSPALRGLKPQSPLMRTTSLSRVASPLLHSDQSHSPVVSPNKPQVTATNNHRLNSSTAQVDVKFGSQNHSSEAVPRTHSSNKRLRKDEPVLANVDVSNKKQRLNGESVCGSNENLQVPSPTFNEKTSELVEPSSSTESNVVKKRGRKKGSKSIKNQVSVEDSVKEKLASISRNKKLKTTQELLADLQARGSNANANLLPSHSVNQPKVENNLRTKNNEDLCKYLSGNQNNSLHKKATDVRTQQQKSGKRQENTCHSSQQKYPEPDVSDQDTVDSEITSENNGRLPQELTVEEILAKLPPLDRSSIDWGSGDEYCSDNENETKKVREVTEEDLDRLHNKCKEGLNGNFQPRLSFGNKSATEKTCEDEVKLDSVIGLRRRSDSHKDEVFREWHEMLAKPSFDGQILHILPYVIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0A5</accession>
    <name>A0A232F0A5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001468">
        <property type="protein sequence ID" value="OXU23858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0A5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12303" checksum="51E8752ACF09E156" modified="2017-10-25" version="1">MGGEETIDFTDKMSNLLKQDLLQLVSVFCFVKSQLTVPPCKIETNPVVDLPFDRSHPSNLLDQPIRICKHQQVIQKHNQLQFDTILGEHVDTWAIYALAQAQDLENSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1V0</accession>
    <name>A0A232F1V0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium-dependent phosphatase 1</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001275">
        <property type="protein sequence ID" value="OXU24532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1V0"/>
    <dbReference type="STRING" id="543379.A0A232F1V0"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000127">
        <property type="entry name" value="Magnesium-dependent phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="162" mass="18726" checksum="BCF03E9D3DC9B0BE" modified="2017-10-25" version="1">MSEKKPKVVVFDLDYTLWPFWVDTHVTPPFRKGQNNKIVDAHGQAVQYYPHSPEILKQLSEEGYEIGIASRTSEIRGANQLLDLFGWNKYIKYKEIYPGTKTTHFSKIKNASGVEYKDMIFFDDEQRNISDLTEVGVLSILVRNGVTHKVIQEGMNQFAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F393</accession>
    <name>A0A232F393_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_008929</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01001095">
        <property type="protein sequence ID" value="OXU25145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F393"/>
    <dbReference type="OrthoDB" id="10070999at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06705">
        <property type="entry name" value="PDZ_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF414">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="504"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="779"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="1101"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="233"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="816"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="876"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1066"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1192"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1317"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1419"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1543"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1688"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="961"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1066"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1213"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1317"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1349"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1467"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1510"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1566"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1714"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU25145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1748" mass="191340" checksum="8BCA3B583973AA09" modified="2017-10-25" version="1">MDQPKNRQSRPRLRTHSNSARVLVFDQAESQEQSAASSTMEPQQQQQQQQQQKQPEVPRRLLSTSKVESKEAPVRPVSTELSNLVRMRNSAIGKSAPSLSIHMRDFNIPRRATKASHRKSFISTTSPTLPRCHSPLSAFVPIVGSPLESPRMSSSPHFAFVPIKRIGGGATNTADGRRWSVASLPSSGYGTTPGSSNVSSQCSSQERLHQLPNIPTKDELRMLSCHFSKPGTPCSSVHPGFPGSSSSSGAGTSGGHNHSLDEESAAGGRRSPLHRPRSRSLSSPSRSPILDSEIVMMNTLYKERFPKATQQMEERLTNFINENKDIDEYEMVTHMAQDSLPILRFVHHQVIEMARDCLQKSQEKLITTRYFYEMSENLEHLLMETKDKSLEAATRLTGLIKKLLLIISRPARLLECLEFDPEEFYHLLEQAEGQAKITIGIEKDIPQYIINKLSLNRDPISELQEEMNKLEDSASSSDSNLQLATSSPNKQDEQRSRVPCESDYEILKLISNGAYGAVYLVKEKSTRQRFAMKKINKNNLMLRNQVEQVFAERDIMSFTDNPFVVSMYCSFETKKHLCLVMEYVEGGDCANLLKNIGPLPPDMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIEKDTRQFSDKQVFGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETPEELFAHTVNDDIEWPDEDDWPVQPEAKAIITALLHQSPRERLGTGGSHEVKDHPYFYGVNWNTLLRQKAEFVPQLTNDEDTSYFDTRMDRYNHDLGDDTDDTDDSPLFGSFSSYSPQSRKISQTRPPNLNPESEPDSLKKQLFRTELERTVAQLSLNSPVSAPSFPSKLDDSLDKSNDQGDKSTLSSNTSSSSANTSTPVSSRTVDLNKTASPDTASSSDSQLTVRKTPPSAPTPGTACHSTPDSSQTESDDISPQIQRKRLAHNRDKLPRFSISFDDESNNTLDLTTANRDSLEDKMNSSTDSFESFSALPLLPTGKTKSRSVIKSASTSGLSLVIPTVDPSTSVQAIESPGGSSTASSRDTSPCRELSPLVTSLKPPIIIRRGPRGFGFTVHTIRVYYGDSDFYTMHHLVMIPMRLQAVDQSSPAFEAGLRPGDLITHINGEPVQGLYHTQVLQLMLSGGDHVTLRSTPLENTSIKTGGRKREPAQSKMARRALHQRQRKQKRDHSDKKRKTSLFRKISSKRASVEMQQVEIDRETMGVVEDVNDTDDKHHPLSISCPLSAPMLSSDSKPPLMMAAGICSPSMVTPSRSFQAFARSAQQQQQESSMHFSPSPPTNRPLSESYSIGNASPCSSPNSSSAGSSGSLASIGSGASSGGPNGSSTGCSAGVSTGSLGSQAHFSQRPSTLHGLKHKLHTAAKNIHSPNRRKSVGHIPLSPLARTPSPSPIPASPTRSPSPLAFPTGHQPGSSNTTQSYSPGASLSTPNSQKKTYGRPKSAEPGSPLLRRALSPDRLHPRSAENKTSISPLANAGLVKVTPRLSISAQSTYPESSDEGGGCSDSSQPGKDELGCKAESVKDRKSTIEPQQKSGPDYSKLGHGISISIANVPIPMNSSQLPRIAEEKDSPTGNKDLVEAPASVPPPPPTPSTVEPVNKLVKQIQDESLCETYDVQRKSSGSDVGLLLTKATTTTTSAESNSDISGKCDSNESRKSTTKSFQSDGTACSSRTDAMATTTSHQSNPSADNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3X3</accession>
    <name>A0A232F3X3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_005286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001076">
        <property type="protein sequence ID" value="OXU25229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3X3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="113" mass="12870" checksum="90F98538D6AC8D2B" modified="2017-10-25" version="1">MADRNPDSQEARIKGKHCRRLNFGDDANDDSLPSKEEIERKYAEELDQHQKEKQAKWNFDFKLGRPLEGHWEWERQDNNNEMTNGRNSSTAAAPGNSDARSGRAQGDAANQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4S7</accession>
    <name>A0A232F4S7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000945">
        <property type="protein sequence ID" value="OXU25794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4S7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556721" evidence="1">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10296" checksum="6BEEDBBA620161AA" modified="2017-10-25" version="1">MRLTVTTTTVFPLLIVLLVLVVNAAYARPSKAERERLSQLLQQQCDELAPKINSGTSDEELKNYIQQPELVKTFNKDQIITACKYKIYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F556</accession>
    <name>A0A232F556_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000985">
        <property type="protein sequence ID" value="OXU25610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F556"/>
    <dbReference type="STRING" id="543379.A0A232F556"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759840" evidence="2">
        <location>
            <begin position="25"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="841" mass="95632" checksum="439FE53B23B1321F" modified="2017-10-25" version="1">MANKSEFLVPLLLFLFHMVSQCSAKQDGPQRHNSSINQENPAEATTTFPVNPYVFSAEDYDILQDAGSLQQALSIVSYEPQKIDGKGLENRAAEKATRRQALHRPPSPTTTQLPLEKKYYEVPRKQSRSRVNNAEREAPRANASKLAGEASSPRRAYEPAPENSFHRHPLPLYPPLTERTVSNSANNYGAASRADDAVKRIGNRAQKPEELVQTRDRVPRPFSLPTAPRRTTASIGQSAESLPTAQALAATAQTRNRASTRQSIPRPTEQKLLIELPAKLDQDPQQTAPYATEFAHHFSQQEFPSQPVPRAVPARQQQHSQTIQHSIPSRQYPSPSPYSTTSGSQEQIVTFRPPQRRNSVRRATSTEQPTVYTVPRRPDRAGVGSVPARQTPTVPTTREHLSTTATREEHQSLPYGTVPSRQNLNHQRLPSRRKIARQDVQADVPPPTVRAEHNSGTMSQPIYVPATIPPRRGPDNLDRSSQENKDYKEYVVDDGDSNEYPSSNDNKQYSYSHVERYVEPLDASAEEQQREPSYEVIEDALDYPDRAPAARAKNSPVLQRGALKRVVPADYNEQGLQYVEPPADYDQTQGQNVNQPEVAEAQHHPRGEEADLVQEADHHHHHHKKQHKPKKEHREAEEGSSEEHHGAEHHEHGEHGKKGYKEQHEHDEGEKGHHDKEKHDHHYDEKEGKDKEHHEEAGFDEHHEKGEEGEKKAAFSEKGHHDKGHSTKGQHVIHKKDEFEKKTEFFDEFHEGGDMEKDGGYHEEHHHKKGGHQKKGHHHKGEHEKHHGEKGHHDKGHHRHEKKGHSEEEGDDHHHHHEERHGKKAGHADQKHWHHEKGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5H8</accession>
    <name>A0A232F5H8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000927">
        <property type="protein sequence ID" value="OXU25862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5H8"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF72">
        <property type="entry name" value="FI21449P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144671" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="709" mass="81044" checksum="1E6F09054AED99F3" modified="2017-10-25" version="1">MCKKVAVTLLFLALLQNGTTEAPQREEILRRTLPVYGLAAASSSALEGSDDAKCRSELELFRRAVDDGMLWAMKMLDSSGEPKPGFVYGNNYWLGSRSQCLDTRNRAPFVLQSDVMGNNSRLRDPSQEFPPYGVNYFVAYFRHNSTLQYHVRLPNEDLVSLGLCLPDSCSTSELGEILSAMFKERSLIVGDLYSADFRLVQVRDLKDDHLWLLNGRIIFIKLVVASILALMLVGTAYDVMLRRKRVVVEKEESELCENNNERIKLSDNLEAAVVKRKRKPGVMGKILLCFSVYSNTRTIFSTKLNSNSVAPIHGLRFLGMVWIIMIHTIFYMSDYADNKPWSWRIAEGFAVQVLSNSTLSVDTFFFLSGFLVAYMYLTAHRDDRPGKPNYGLKVLEFIVTLLRRFIRLTPAYMMMVGILQLNASWYGRTSQFHMTERPHETCEKYWWRNILYINNLFGRDTMCMSWSWYLSNDMQFFIIGIFLLILSSVYFKTAAVILLCLLIGSITSTGYIAYINDYVPTMDQQYHMLDVLYDPPWTRIGPYIVGMITAYIVIRLNNKLELRRRTVVTGWLLGSSCNLVVLFGLVDKQISVLLSAFYVAFSRTVWAVGLAWLLVACCTKHGGIVNKILCFKAWIPLSRLTYCAYLLNPFLINSIYLHSESAVHVDFLPNGAIFLGNLMMTYLCSYALSLMLETPTVLLMRTFFGVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F798</accession>
    <name>A0A232F798_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000861">
        <property type="protein sequence ID" value="OXU26167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F798"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="49" mass="5953" checksum="A573A62F1577985E" modified="2017-10-25" version="1" fragment="single">RYTLKPVWVTESFYNTTLEKVLAHECDLVEYLGCFYDIVYYEPEEIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7G9</accession>
    <name>A0A232F7G9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide-binding protein-like 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_005654</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000781">
        <property type="protein sequence ID" value="OXU26542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7G9"/>
    <dbReference type="STRING" id="543379.A0A232F7G9"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000493">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="84"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CP-type G" evidence="11">
        <location>
            <begin position="415"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="742"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="853" mass="95093" checksum="C2204D6F1C25E31A" modified="2017-10-25" version="1">MASPRATISIIKCLSPQKIHNVSSIRQALSPKSPATKSFRQTSSPKTPIRNSLSAENILNGLQSPIFKIDTPYKRRIVNEGLLDECRTVLGNGAFGTVYKASYKGKEVAAKVIKNNKRIDSSIDMEKEVSFLRHSNIVRVLKVDEGPAMTLVTMELCGNSLQNILEQNPIRSEERIFIWISIAEALKYCHKMGVVHADVKPKNVLMGSDNQPKLADFGSAIFIEETETTSVFHGTPGYAAPEVVRGNIPTPLSDIYSLGVLAWQMLSRTPPFSGLHKHTILYLTGKEKPSKRIQARKRYKIEKKVRDHNKKLKKEAKKHPKKKQKIIQVPNQCPFKEDILKEVEALKKQKEEEKQKRKEEAKQRKRDELEKAGLAGLVANAENKQMEHDSLETITDSNKTEKFGKKEENSLKAYYKEFKKVLDEADVILEVVDARDPLGTRCKQVEEAVRLAKGNKRLVIVLNKADLVPRENLDQWLKYLRKSLPAVAFKSSTQDQAKRLGRRKLGKKSEENIQGGTCFGAELLLSLLGNYCRSTGNTKASIHVGVVGLPNVGKSSVINSLKRSKACNIGNTPGVTKSMQVVQLDSKIKLLDSPGIVFENSKDADASAVALKNAVKIESLHDPFTPASVILKRISTHQLMEMYDVTEFTTPEEFFAKKAARMGKFRKGGIPDTLAAARSILTDWNSGKIRYYTVPPEDKNTHVSASILTSSLKEFDIESFAAEEKMVLDGLASDSSKSILDPLEISSTGPVESTMDVEGENESDVKVQSKKGKKKKKVDDKKNVPVQRKKKVDPIFEIEGNQQLNQIKKLAFKKQKKQAARSAKKAGVLADVLSGVNLKTDDNYDFKTDFSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Z6</accession>
    <name>A0A232F7Z6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_012198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000776">
        <property type="protein sequence ID" value="OXU26573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Z6"/>
    <dbReference type="STRING" id="543379.A0A232F7Z6"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="91"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="212" mass="23863" checksum="9A8867DC045CCBDE" modified="2017-10-25" version="1">MLISQILSKKMPSYKVTYFNIKGLGEPIRFILSQAGVDFVDDRVESADWPKIKPTTPFGQMPVLEVDGKKINQTNAICRYLAKQYGLAGANDWENLEIDATVDTIHDLRAKIGAYYYETNAEAKAEKEKTAKELVPFYVERLDEQVKKNGGYFVGGKLTWADLLFVAVLGYINGIAKEDIIAKAENLKALREKVLNLPNIKAWVAKRPETEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8B3</accession>
    <name>A0A232F8B3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000714">
        <property type="protein sequence ID" value="OXU26842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8B3"/>
    <dbReference type="STRING" id="543379.A0A232F8B3"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000060">
        <property type="entry name" value="CUGBP Elav-like family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="187"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="279" mass="29580" checksum="9E2D24892778F3C8" modified="2017-10-25" version="1" fragment="single">QGASSSLVVKYADTEKERQLRRMQQMAGNMSLINPFVFNQFGPYGAYAQQQAALMAAATAQGTYIGPMAALAAGQLPHALNGMPNTVVPPTSAGSVVGTGTGQPVNGALPSLPSPTMPNFNMAAQTPNGQPAGTDPSVYTNGIPQTYAGHALHLSIPAQGLPNGEAALQHAGYPGMQAYHGVGPEGCNLFIYHLPQEFGDAELMQMFIPFGNVISSKVFIDRATNQSKCFGKEFRVAGFVSFDNQQCAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8W9</accession>
    <name>A0A232F8W9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000701">
        <property type="protein sequence ID" value="OXU26909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8W9"/>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257647" description="Kazal-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="9813" checksum="82CEAE5B34CD1FFA" modified="2017-10-25" version="1">MMKLTVFLFATALFCAIANVNAQLESDDYEEEDECPCMTPFNWLPKCGSDGQTYPNEEAIKCQNECNDDRVTIAHDGVCEGDVHFGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8Y6</accession>
    <name>A0A232F8Y6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000634">
        <property type="protein sequence ID" value="OXU27286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8Y6"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000113">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000324">
        <property type="entry name" value="Putative Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000150">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011071">
        <property type="entry name" value="PRK14501.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1438"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1438"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1551"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1599"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1610" mass="180730" checksum="62D26AB639A6C366" modified="2017-10-25" version="1">MTESRSYSSNGSMIVVSNRLPFVLKRNETSGKLERKASAGGLVTAVAPVVINGNGVWVGWPGMHMENRNEPIPESDPNDRTPTAGLLSRKVVAVHVEPTIFDSYYNGCCNGTFWPLFHSMPDRATFIADHWKAYSAVNEEFAAKTVGALEQIHKEQAGQGNGTPLVWVHDYHLMLAANWIRQAADEKNLKLKLGFFLHIPFPPWDIFRLFPWADEILQGMLGCDMVGFHIQDYCLNFVDCCQRSLGCRVDRKNLLVEHGGRTVRVRPLPIGIPFDRFVSLAETAPKVMLTNQKIILGVDRLDYTKGLVHRLKAFEMLLEKHPEHREQVTMLQIAVPSRTDVREYQDLKLEMDQLIGSINGRFTTPNWSPIRYIYGCVSQDELAAFYRDAAVALVTPLRDGMNLVAKEFVACQINTPPGVLIVSPFAGAGEMMHEALICNPYEIDEAAEVIHRALTMPEDERTLRMNHLRRREKAYDVNHWMKSFLQVMGSLEERDSVGATVMQPVTMDDFDDYLSKYIGENHKLALLLDYDGTLAPIATHPDLATLPLETKNVLQRLSNLPDVYIAIISGRNVNNVKSMVGINGITYAGNHGLEILHPDGSKFVHPMPAVFESKVASLMQALQDQLCKDGAWVENKGALLTFHYRETPMERRPSMIEQAKKLIEDAGFKACSAHCAIEAKPPVEWNKGRASIYILRTAFGLDWSERIRIIYAGDDATDEDAMKALKGMAATFRVASSHIIRTSAERRLPSTDSVLTMLNDNRVTSATSPQQLFDGASDNNNNTRKASSSSSIDEIQNDGENFVSTLTVLLMKSSQEQNNSNRWRRRQSSTCSPVLEDVDLVLEDNDQVINASPETIRHSESCAGHETVNTSLPSEFISKISNLNLNYDEDEVAENEISECTIDISGSSDVIFVESAKTSMEQTVCLSSDEEKSPDVMVLKHRDSVLLAKKELRNIVYDVDTSFEKPELEEVVPGNDDVDDDCVSDQVETMRNADVSKVLNMSLPLVDWNKGISTEDDETNQSLSEALLNVSIESPEKKQSTKSRVMKDVPCPPTHKLTEAEIFDRHTGLPKHELLRDHFEKEGRIEESAALRILRMGAEIFRKEENLLKVNAPITVCGDVHGQFYDLLHLFEVGGSPCSTSYLFLGDYVDRGYFSIECVLYLWSLKIFFPTSMFFLRGNHECRHLTEYFTFKQECLVKYSDTVYEASMAAFDCLPLAALLNNQFFCVHGGLSPQIMELNDLARINRFQEPPSHGALCDLLWSDPTEDYGKERTPERYKDNSVRGCSYSFSYQACCDFIERNNLLGVIRAHEAQDAGYKMYSYLHHEKGYSTRYFFFQVTQMLLGLLQICSDDELKDDEEAAKDDGVLTAARKDVIRKKIKAVGKMARTYTVLREESESVLQLKGLTPSGSLPRGALSEGKSSLRSAIHKHISFKEAKSMDAVNERMPPRKDSVSLTPKSSFSSPTDNQFVTPRGTATSLSPESQDWFSEPSTSSSNFEDLRSRKILFASRNSPPTDLPAKVAKPPRKSPPSDKEEGTAVRSKIPVLNRNRSKTECHESEDSKQPSPPLMRRKSAPANGHWTSSRNIDETDEAAVCDNESENREQEASQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F920</accession>
    <name>A0A232F920_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000624">
        <property type="protein sequence ID" value="OXU27326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F920"/>
    <dbReference type="STRING" id="543379.A0A232F920"/>
    <dbReference type="OrthoDB" id="7691309at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="189" mass="20612" checksum="C979E8242C22B70D" modified="2017-10-25" version="1" fragment="single">MGRGVGPEESGHRLDSGSPFWRIQLDQDLLDTISAIYPEWFKDYTSSRASTSGPNAPASLQSHLSQLSSSSSSSNSSSSSSSGGSTARKPAKPESKLKSKLKKIEEKIFKGRKDKRDIKENRDRPSHEVSHVNKKLTKAYSSKEKTGDIVLKKSATSISGSKMAEGNQSPPKAEVDDSPLQQSMDRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F927</accession>
    <name>A0A232F927_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proton-associated sugar transporter A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_005189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000620">
        <property type="protein sequence ID" value="OXU27354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F927"/>
    <dbReference type="STRING" id="543379.A0A232F927"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17313">
        <property type="entry name" value="MFS_SLC45_SUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="71032" checksum="5D7505E563BC2C36" modified="2017-10-25" version="1">MADKLAEYEGLQGRVHGLRDKAREKWDTFKEWKSAIPTDRGLEGVVSHLRGPPKLERCLDDYAHVYRKKTRWELVRVSAAVMGIEFSYAAETAFVSPTLLKIGVDHQHMTLVWALSPLVGFFVTPILGSVSDRCRLKQGRRRPFILLLAIGVLMGLLLVPNGESMGYAFGDTRMNFTAALGHRITGKTAHNETLPPPPPSSHSWGIFFTILGTVLLDFDADACQSPARAYLLDVTIPEDHAKGLSTFTIMAGLGGFMGYGLGGINWDATSIGVALGGHLHATFTLITIIFIICVASTLTSFKEIPLDFLESDDCKEQLQRKLEEERKQNEAEKMIPDESATYGTIGNEQEVDSDVNPEEIPMKPIEQPPPAPRKPGTVPMIPDVQPAPRPADEYAHLGAPASESAPNPKATLQEYLYSILYMPHSMRMVCLTNLCCWMAHVCYSLYFTDFVGEAVYGGNPKAPEGSKERELYESGVRFGCWGMSMYSLSCACYSLIIEKLIQRYKARKVYICGLLFYSCGMMMMALTKHPAGVIIFSWTAGVMYSTLFTMPYLLIAHYHASGTVSQRDGIPLVFAVTAEGEAIQDGGLRGLGTDVAIVSSMVFLAQFLLSCCLGTIVSLSGTTTAVVCVASTLAACGALAATQIMYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9U1</accession>
    <name>A0A232F9U1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000604">
        <property type="protein sequence ID" value="OXU27435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9U1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="7126" checksum="B6A9D37E27567202" modified="2017-10-25" version="1">MDYLFTKDVKSITETNHLWQFHDHFGLGCKEDDDIVDDLVLKFSIDAKKRKIVNLCLAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA74</accession>
    <name>A0A232FA74_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DZF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000623">
        <property type="protein sequence ID" value="OXU27333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA74"/>
    <dbReference type="STRING" id="543379.A0A232FA74"/>
    <dbReference type="OrthoDB" id="5775647at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000093">
        <property type="entry name" value="Interleukin enhancer-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DZF" evidence="8">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="381" mass="42190" checksum="C3F73A69554F0CD6" modified="2017-10-25" version="1">MVRGRGGIIRGRGMGRGMGFLPKRQFMPRHPFDLTLCEAAFPRVKPAPDEADFTAALLKKNQDMCPTPKEQTSILNLVTKLQSVLDNLIVAPGTFEACQLEEVRQVGSFKMGTMIKGHNVADIVVILKTLPTKTAVEALGNKVQTDLKAQAPKEALRLTQTERGFDITNNEATVRVLITTLHQNLRKLEPDQHLDIKICQGHLAAIRHSRWFEENAHHSSIKVLIRLLRDLRTRFEGLEPLTPWMLNVLAHNAIMNNPSRQALPINHAYKRVLQLLSSGLFLPGSAGISDPCEGGSIRVHTAMSLEQQDLVCLTAQTLIRVLAHGGYRPLLEGGNKLAVEMSVWSGGVVASPLEKAYEPPTEQEQQEDMDESNEEMIAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC68</accession>
    <name>A0A232FC68_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Activator of basal transcription 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000481">
        <property type="protein sequence ID" value="OXU28080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC68"/>
    <dbReference type="STRING" id="543379.A0A232FC68"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="27163" checksum="1D8C178552D5417E" modified="2017-10-25" version="1">MAKKRGKVISENKNNEDSVEERVESEENEKTEEDQNMEESEEENMNRKKMLAKPEKKKKRGIIYLSTIPRYMNVIKIREIFSAYGEIGRVYLQLADSELEDKKKLKKKKRKTPAKHFTEGWIEFESKKVAKFVAATFKWTHLSERLAYERAVHKQRLRAEIAQAKREVNFFSYNVDRSKKLKMRAEKGESSNFVMPEIKQRETDMEIRKKKNQLQDEDRTEFLKSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCJ7</accession>
    <name>A0A232FCJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Nonsense-mediated mRNA decay factor SMG8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_008981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SMG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000419">
        <property type="protein sequence ID" value="OXU28536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCJ7"/>
    <dbReference type="STRING" id="543379.A0A232FCJ7"/>
    <dbReference type="OrthoDB" id="63589at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019354">
        <property type="entry name" value="SMG8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091">
        <property type="entry name" value="AMPLIFIED IN BREAST CANCER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13091:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10220">
        <property type="entry name" value="Smg8_Smg9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="905" mass="101909" checksum="0DD98E4496AB0C42" modified="2017-10-25" version="1">MRPQKFVIPCNSESFANLDRKVIIVSVFGKSQYRAKGCKAEMFSSVLQMDLLDEPGVDKGSLCEIEGYHDPKTRTVYLHLRGLLDAHTLINEYDQFIEKQDRKDFLSAWAHMRNKYSRALLVLFHLSHVVILSHPTHTFDHSYVHLFRALDIVRQKTSAQLSDFLSSVPGVPKDWISNGRPCSPRVLFYFESCPPVFRDVDSEANIKKLEHSLEDRIYQVLRKNRIVTNISSNSLFAIPANQEFVFVHTGDTETRDILAYMTRQLVKSCTVTSGGINVKPYLNIDPVVNNDDTEEEPHTFKRFLQQHINLAFSKGFDDNVGRHPAPSHFEIPTLSLFFNVANKVYEFFIQGPDKELLSLHGLLDTDVKFSRSRCTKVLPRALQAYQENLPQHYTRTYHESKLAHAMAVFEMHARGPLFDEFSEKLQEECDKHWRAGRQMCQVLSLTGNPCTNPIHKGGGEGAGGGEQLDTREDYNDLLNMEHCSGVRYICACNCGRCQGSREDPFNLKQANYDYFQMLAVQCGCNQLESIQFPVFQPSTHNYRAAQLFSTTNRKDSLIRAEIATPQGHTQICSLGVNDEITAYGSGGQSPPAQSDLIEEDTQRLSDKTSFTPGDENKVVIAVTDVDSENSKEKSLIRQPSTTEYLPGMLHTESPAGLLPQFSSWSLVCLGSSSIYSHNLGLQHQTGVLANSAFLLPWDVTVRLEHQKERGSLWPTVNDNNQHNFCQRGKNFQNLSAIRGRKSKKGKELLVKIFVGVEYECPRGHRFMASTPDKVLKATGIGTVKDNGNKVTSSTTDMPLYFPCPCRQPKPLIAQLMRIHVVTPKAPVHVTLNPRIQPGPPPCPIFVTGCEEPIKLSQSAYWILRLPYVYMGDKGPYLPPKEPVPISHGRLLAGMYGISEVVGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD15</accession>
    <name>A0A232FD15_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000392">
        <property type="protein sequence ID" value="OXU28694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD15"/>
    <dbReference type="STRING" id="543379.A0A232FD15"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="2">
        <location>
            <begin position="104"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34505" checksum="E3082911175770D0" modified="2017-10-25" version="1">MMRVNAKKVKVSFAVDAVDEECFEKTEMTYDEISNNGSIIENKSIPNEILSKILCYTDHNALLLCQLVCKHWHYLIRNYVWHKKAEFTLGKSLTFTEKTPWTVYYFICDQMPFYKNLVKNHSGKYGLFKHWCITENGGTGWNVENPPKAVKQLPDDPVFEDESYCFVTSFSKCWKEQTIYLIDEGFSEYVLDYLQPTIKVSEWFCCRPNVPAIYECTIKLLREQKSDRTAIETLSYSKVLEGEQMNQWFKFTHEFKNYGKGLRKIKFGHGGQDRFYVAGSCGSKMAGACIKLKIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD69</accession>
    <name>A0A232FD69_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Muscle M-line assembly protein unc-89</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_000837</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000435">
        <property type="protein sequence ID" value="OXU28408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FD69"/>
    <dbReference type="OrthoDB" id="6070751at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001307">
        <property type="entry name" value="Stretchin-Mlck, isoform V"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001894">
        <property type="entry name" value="Stretchin-Mlck, isoform V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF171">
        <property type="entry name" value="STRETCHIN-MLCK, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="144"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="246"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="353"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="455"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="552"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="651"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="4675"/>
            <end position="4763"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="4775"/>
            <end position="4863"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="4895"/>
            <end position="4986"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="4999"/>
            <end position="5099"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="5157"/>
            <end position="5257"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="5261"/>
            <end position="5352"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="5380"/>
            <end position="5570"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="5604"/>
            <end position="5643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="894"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1747"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3134"/>
            <end position="3172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3203"/>
            <end position="4034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4212"/>
            <end position="4316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4357"/>
            <end position="4446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4460"/>
            <end position="4480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1752"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3203"/>
            <end position="3245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3252"/>
            <end position="4034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4224"/>
            <end position="4316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4357"/>
            <end position="4403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4404"/>
            <end position="4418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4421"/>
            <end position="4432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4433"/>
            <end position="4446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4460"/>
            <end position="4472"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="5643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU28408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="5643" mass="643870" checksum="70C5C7945E1BCF96" modified="2017-10-25" version="1" fragment="single">[encoded data, 5643 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDA4</accession>
    <name>A0A232FDA4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000427">
        <property type="protein sequence ID" value="OXU28483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDA4"/>
    <dbReference type="OrthoDB" id="536093at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="51900" checksum="5E87DD3D99E5DAEA" modified="2017-10-25" version="1">MNIREEIIDRMLRILKQFSRKLKIAIYLPIIIEELKAKRPTSYRNVKELKKIYALCTSAKLRANQRGEMESLLTNNEQEMTQLILFTPYMQCLKRTVLFVVVFLFSPQESKQVAMIQEEPADLESQCAVILQRSIDYEDDILSVAKDNIELILPSLVNTIDHVELLQQIIDLQVRTTPKQLREREIGLRNADMLIAQTQEEIKSKAYIYIYIYIYISFSYSFVTMNNNYTLPEELRGSIEDETSKHEEMIKKCQDEIAELNLLIDDTRRKHRAELDREMNRYETKLRGLRDDVIEEKHNLDVQLDANEGLVEQLIQADLEREKSLRYYCVKSEKRYIAAQCEYDRDLNKLNELKETLEMQLRVTKTHFEILKNEYDVQSVLFRNLKKERELAMMQAFAEQLDNFEKNRAARIIQRTWRSYHERCLSSKKKKKKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDF0</accession>
    <name>A0A232FDF0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA/RNA non-specific endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000378">
        <property type="protein sequence ID" value="OXU28791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDF0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21917" checksum="FF957082765B9B4C" modified="2017-10-25" version="1">MLLFPMWKTIYRGNWARTNEFIYQMVGVLEEEEIMVYGGASGEFIFVSESGFFTDTRKKAYLDDKDNKLPIPKHFWKFVYNRNKNQVNDPLFNKYASYKPLCEEVTDGLKPDWSLNHEDGYSYMCKPSHILNENLDEIKIWKSDWTPWHDSSIGFLSLSSKENQSKLKTFFAYFGTAMVGAAGAALLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDT7</accession>
    <name>A0A232FDT7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_001945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protease inhibitor I19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000398">
        <property type="protein sequence ID" value="OXU28663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDT7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036201">
        <property type="entry name" value="Pacifastin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57283">
        <property type="entry name" value="PMP inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="158" mass="17902" checksum="C340440D27552A8F" modified="2017-10-25" version="1">MALRTGHLLGKNKKCVPGKSYNDSCNTCVCAENKQDERGAWEPIMFCTEMMCFEPDGTEYKPTSAPEDFWQDNVLERALPEIFRRWDLLVSVRANVVGADDGIAHVRQEKKTVASVASIEIGVTRSANFFLYEKGALFNTNAQKLEIKHNDKTYLLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE09</accession>
    <name>A0A232FE09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_008180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000360">
        <property type="protein sequence ID" value="OXU28902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE09"/>
    <dbReference type="STRING" id="543379.A0A232FE09"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001255">
        <property type="entry name" value="Exportin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1060" mass="122334" checksum="1E882FB1A72C8573" modified="2017-10-25" version="1">MATLAEQASKLLDFNQKLDITLLDNIVGCMYSGIGEQQRVAQEVLTTLKEHPEAWTRVDTILEFSQNQQTKYYALQILEQVIKTRWKVLPRNQCEGIKKYIVGLIIKTSSDPETLEASKVYLNKLNMILVQVLKREWPRNWESFIGDIVGASKTNESLCQNNMAILKLLSEEVFDFSSGQMTQTKAKHLKDTMCSEFSQIFQLCQFVMDNSQNVPLVAVTLETLLRFLNWIPLGYIFETKLITTLIFKFLNVPIFRNVTLKCLTEIAAVTVPNYDDMFVVLFVNTMQQLEQMLPLETNIRDAYAVGQDQEQNFIQNLAMFLCTYLKEHGQLVEKKQLNDTLLKALHYLVLISEVEEVEIFKICLEYWNGLASDLYRENPFVPPILMNKNIAVPPRRLFYTQVLTKVRYIMISRMAKPEEVLVVENENGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERVMTEKLQNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIALKCRRHFVTVQLGEAMPFIEEILSTISSIICDLQTQQVHTFYEAVGYMINAQVDAVMQEHLIEKYMLLPNQVWDDIISQAAKNVEVLKDQEAVKQLASILKTNVRACKALGHPYVMQLGRIYLDMLNVYKAMSENISAAIVLNGEMVMKQPLIKSMRVVKKETLKLIADWISRSNDPQMVLDNFIPPLLDAVLIDYQKTNIPCAREPEVLSAMATIVDTLQGHITSEVPKIFDAVFKCTLDMINKDFEEFPEHRTNFFLLLHAVNVHCFPACLSIQPVQFKLVLDSVIWAFKHTMRNVADTGLQILYQLFRNMEKHEDAAQSFYQTYFTDILQHIFSVVTDTSHTAGLTMHATILAYMFTLVELGRIKVPLGPVPDNTLYVQEFVARLLKAAFPHLTDNQIKITVQGLFNLDQDIPAFKEHLRDFLVQIREYTGEDDSDLYLEERETALRMAQEEKRRQQMAVPGIINPHEMPEEMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE27</accession>
    <name>A0A232FE27_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000389">
        <property type="protein sequence ID" value="OXU28728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE27"/>
    <dbReference type="STRING" id="543379.A0A232FE27"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="69710" checksum="9BAD49EA9C662931" modified="2017-10-25" version="1">MDLLASRLARDAKSKPKKGVKRLSKNDTKENKKKIVSKVDSAAVDKMSKKQKNLQKEVSAKKKDLIKNILQKQESLVKNLIKKNDKDTFAPSQNKVSKPKKVEKGDDKPSAKKVGKKPGKTSKIPDHQVIRSEGEVQTEYTKSKKMQAPLQVKKEVSNSKNTKKIKSQPAKPVAVKKTVTMTKDVGNSKKSKKVKSQLTKSVLSEDLEPPFKVLRVVSNLKKSKKVKSQATKPTLVEKNSVVKTEELSSNAKSAKKLKSQPTKPVAVENNEEIKNIKSKKRKQPETEEQKSGLNLNKKEVVNFVKALIKVIETEQQKKKTLFDSEKPPILMNVNCFKVPKVPLHQHRIKLPHSMISSTDDIAIFVKDLKRGRKRDPEDTVRHYEDIFQQHGITQIKAIIPINQVKTEYRQFEMRRRLFNSYDHFLVDGRISGHIAHLLGKQFREKRKLPTSIPMERKNLKEAIDSSLKKTCIQIHGHGDSSIIQIGTCSMKVEHIADNILAVVEDLSKNFPGGWENIRSLRIKTPLSLAIPIYVSLKSRNEVEVPVLTPKRPKAYHEVEGELSTFTSNVKVHVAPDGSVRVEKLQGDDSDDDTEDSVKKVDVKEEKKENVKKVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE71</accession>
    <name>A0A232FE71_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000342">
        <property type="protein sequence ID" value="OXU29061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE71"/>
    <dbReference type="STRING" id="543379.A0A232FE71"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234850" description="Vitellogenin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="81646" checksum="E1D5D0F1F2F93354" modified="2017-10-25" version="1">MARLVSFMFALLLLFGHQQIGKCEDGKFDIKSLMGNAGTVLKVGKEIYTGIDYVYKKLLPTTTKDSESDAKIEPGMEQRLTDQIKHVAKKLDSLKVDMQNMKDEIIDKISNEIPDQINLKSNLFEIYLRINQIENSYEEFLTYVRDPHKFSNDTLKRFAKAVTSPELTELPNVLKTIHWLLVQTDVDIGDSVLTVLSRSTQIPRQMCKTQQSLQQMIYNLYNAIALTDVKGYAMILFGHHILQYIKGTLLKFATNANSAYSTDDKTSEIQVAEEQFERRITTTMKAVAKAMKPASRAIWTCDTYGYKEGVTYTKLNNVFQKYFINEVDLNPEGTCTKTCPEYKQTKAYGCFDDKICAKQRTCSGDLWECEHKVSSTMYICASDKKSDRRYEYVEYGNSQRYGPKGRCANPAVEVYGWGRGFSHCTYCLCTCDDLGHSNSDRYKIHLLNFINSVVTGVRFRKSNNIIHIQIQQGQLLPGGIINQTTVSWVPIEDYKINEPMPGSEGTRWEYVPVAERDYHVLEWKVKRELHRDDKFMYRKAAVNLDDLDFADQGPSNYSNYLVGGLRFTADEVKGSGYHLNLDVYMVPFDYTTGKLRLWEVISPWFSSARQLSERGRLIRVSDKVQVNLENLDVPTNSGAPAVPTSQSNQFLYFTTTGLDADAGQTTIPFIDLKPVQTYPPTPLSGAGLFHKSSPGSGGFLSFKLFTYDYSSQLQIKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEG5</accession>
    <name>A0A232FEG5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000371">
        <property type="protein sequence ID" value="OXU28829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEG5"/>
    <dbReference type="STRING" id="543379.A0A232FEG5"/>
    <dbReference type="OrthoDB" id="439236at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071546">
        <property type="term" value="C:pi-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157:SF3">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="277"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="377"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="431" mass="49516" checksum="D73F1F99F3238686" modified="2017-10-25" version="1">MAFNGKSNLNSYDDNNHDQFFEIDEVSEFDTASFNDDFINSFDRQDMNNKTKHQIIIEACMKGNLEIIEEFLECGHGVNEFLLTGWSLLLYAASYAQSHIVQFLLNSRADPNLHQDGYTPLMALCSSTRGTPLKRITCLTYLIEADAYVNAANKLKETPLMLACKMQEIDFIEELLQYVDNINFADSEQCTALFYAASVNRYDVVELLIEKGADINWINYRGLMAYDIAQIKGFEDLLPLLNVNHDEEEQEKLQTNCVSCWTDMFSPGNDMDMEVIDNDVLSILYGMGLESYKNCFKGIDLKRFLRLKEEDLEKLGIDISVHRTKFVDELFRFHKHEWNTNPMTIDESQPFSTFNAIQILGNINKQLTVMSSSVYFSKNYLNSLEELEDTNITHEDKERIENEIKNLQATALRIKDATNRLDNLAKASSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEJ8</accession>
    <name>A0A232FEJ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_000203</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000388">
        <property type="protein sequence ID" value="OXU28737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEJ8"/>
    <dbReference type="STRING" id="543379.A0A232FEJ8"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000002">
        <property type="entry name" value="Probable histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000031">
        <property type="entry name" value="Putative Histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF10">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="181"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="485" mass="53919" checksum="9CB89A5588AFB28B" modified="2017-10-25" version="1">MSQRKVNTNFQKFHIQILKLKTKKAYSVFNDRTEESSAMQYFQFYGYLSQQQNMMQDYVRTSTYQRAILGNSVDFKDKIILDVGAGSGILSFFAVQAGAKKVYAVEASNMAYHAELLVAANNLSSKIIVVAGKIEEIEVPELVDCIVSEPMGYMLYNERMLETYLHAKKWLVPGGRMFPSRGDLHIAPFSDENLYMEQFNKANFWYQTCFHGVDLSAMRSHAIKEYFRQPIVDTFDIRICMAKSVRHVVDFQSAKETDLHNIGIDVDFHILESGTCHGLAFWFDVAFIGSTQQVWLSTAPTEPLTHWYQVRCLLENPLFCKSGQLLSGRVNLIANKRQSYDVTIELKLEGTNLGSSKNTLDLKNPYFRYTGAAAQPPPGLNNTSPSESYWNTIDAQGARQAVNMVNGISVNGLGEVSMEAGSAVHSSTLIAVGQPNIHPGLISSTGRGRVSVSATSTQAAQLIGGGITPNLFTSPSTVNIFFGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEL3</accession>
    <name>A0A232FEL3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_015790</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000354">
        <property type="protein sequence ID" value="OXU28960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEL3"/>
    <dbReference type="STRING" id="543379.A0A232FEL3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000429">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="427"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU28960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="469" mass="51966" checksum="2BD886BFC3228FB3" modified="2017-10-25" version="1">MLKSCSNQPTQLWFMVLTICVGYLNADILVFNAEDTHKVEQGFRDLPARFGGMIPAEGIKGIVIYADPPQACHDIKSPPTNNTKYSGNNWIVLIARQNCSFEDKIRNAQKAGYDAAIVHNVNSNELEPMSAKDSTNITIPSVFVSEFTGSLLKEVYAYDEGYFVLINDLPLNINTHLLLPFAIVVGICFLVMVIFMVVRCIKDRRRQRRHRLPNSSLKKIPTHKYTKGDPYETCAICLEDYVENEKLRVLPCAHAYHTKCIDPWLTKNRRVCPVCKRKVFAADERVETDSESDSDADDSTPLIRDGGRSGTQGGTFEPQTENPFRRPRQRHRRDSQNSGSSYDSAVGETNAGNDEAGGGRVGVEIDDGDSIGHVDSTSRSVFLVSDCHSINGEMPDFDRSVSSTKPHTVNLSVDIDENSALDANHHAVQRHGRGAPRAGASNPMPRSGDSRTPVTDIIRSLSDDNDVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEN3</accession>
    <name>A0A232FEN3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000323">
        <property type="protein sequence ID" value="OXU29216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEN3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="394" mass="44918" checksum="A569B738B81881FF" modified="2017-10-25" version="1">MNRLLSSMVNTEGCYISFSIEAKEVVIDGFVTITYLNLVSDAFDAIGRPGDDLPVALLISRVFLSRLKAVRAELLLPGVLHEVPALRRHRSRLRFHRYRYSFILSAAARRLLSCNRKEEIMPSLAILDLFVEPMISSMNTRSFHNLSDTFSKTNNRHTALPIETKTNSKIHLAVYPSSVSSHSYFDKQSSFHPAYSTSNLLSNKNSISPTQKMARPSSRSIPRVALASPSTPAAENQRRLAVSRINNIVTGVGVSNPAPVDSNNNSRHERLRIFISVINYNDRRSATSNADPTVANTRRIERSVRNRSAASRPSQRPERARGRGARRAEREQQEEGVEEEDSEDDEFSSSRRSSRRRGKCDHNHALEKSFCSKCHIRRRHLCRWWCRQQYRRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF31</accession>
    <name>A0A232FF31_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000300">
        <property type="protein sequence ID" value="OXU29364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF31"/>
    <dbReference type="STRING" id="543379.A0A232FF31"/>
    <dbReference type="OrthoDB" id="7700607at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="315" mass="35226" checksum="E29A7954868FF843" modified="2017-10-25" version="1">MTLTKQAKKSLKKRNGLQVGAEERPLKNRASEEATVVQKQQGIAPVKMSKDSRASSASRRQEPDKQQQNPPKSQASKTDKEQQQQQQHEDSTGSKDQTKLDRKPSLRRKFNALLRGSADLPAAINRGLQPIRRSMSFGKGLEQQQQQQHQHQHQQLQRRPTPPSSAGSLKPFRTRSVQWYNSLSSLAEHEAEEKPGCAFAASEEQIYCEGKPVSRTHSLVEKSPDAVPKRRANAAISAPYGRHSDHYDFSIDLSKPPCEASSLPVLTRDTIDAEDVEAGKSLLLDAVVFILHFVSLNECVPRVKDDGLRQENSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF39</accession>
    <name>A0A232FF39_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000310">
        <property type="protein sequence ID" value="OXU29305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF39"/>
    <dbReference type="STRING" id="543379.A0A232FF39"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000045">
        <property type="entry name" value="lipoyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="70"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="388" mass="43950" checksum="9171C1D7E5FDD01E" modified="2017-10-25" version="1">MSVICRTSIHKAKALYNKFGELSLVLRHASSSSVKNVPEEDIKKSVFISQSSDIYTNLALEDWFYRNYDFSKHHVLLLWKNDPCVVIGRHQNPWVECNVPAVEQSNIALARRNSGGGTVYHDSGNLNLSFFTPRERYNRRYNLDIITRALFREWGLKSTINKKEDIVVQGEFKVSGTAAKLGRPNSYHHCTLLVDANKQALSLALKKTETGITSKATESVRSPVKNLKEVNSHIRTEHLLNAVGWEYLRTKSLTLQDGGHQLVQQQKGFQMINPTEDWFPGIEKLTEEFRSWDWTYGKTPVFTVTRLLEAPTQDGQNHLLKLIIEVEKGIVQDIKMTLPSDLNRDASVITNLRGKRYSHELTDSIVEATGCKVVAQDVVVDESNVAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFT1</accession>
    <name>A0A232FFT1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000275">
        <property type="protein sequence ID" value="OXU29562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFT1"/>
    <dbReference type="STRING" id="543379.A0A232FFT1"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000001">
        <property type="entry name" value="Putative cop9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058796">
        <property type="entry name" value="COPS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25983">
        <property type="entry name" value="COPS2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="255"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="444" mass="51564" checksum="9630F9CC3FA0A53E" modified="2017-10-25" version="1">MSDGEDDFMCEEEEDYGLEYSEDSNSEPDVDLENQYYNSKALKEDDPKAALQSFQKVLDLEGGEKGEWGFKALKQMIKINFKLGNYKEMMTRYKQLLTYIKSAVTRNHSEKSINSILDYISTSKNMELLQDFYETTLDALKDAKNDRLWFKTNTKLGKLYFDRSDFNKLAKILKQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKTLYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFERAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVVSYQNNDINQFELILKQNRNNIMDDPFIREHIEDLLRNIRTQVLIKLIKPYTRIHIPFISKELNIDASEVESLLASCILDNTIRGRIDQVNQVLELDRKSVCAARYNALDKWTTQLQSLHLAIVNKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG15</accession>
    <name>A0A232FG15_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000251">
        <property type="protein sequence ID" value="OXU29701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG15"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759833" evidence="2">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="20579" checksum="190914A2440F6FE3" modified="2017-10-25" version="1">MFSKALILVLLGATLVLSSPAHTLDDQIELRSSWKENINHIWNKVQQTAKNIYDKLKNTYDQSLEEVKKQVGNAVELGKEKYHELKEKYEELQEQAKVAIEQEKKIWEARIEELKHQGAESVEATKEKLEELKQKAEKAIQEQKEKWQVKYKEWKKQVKEALEHAKEALEQAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG73</accession>
    <name>A0A232FG73_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_015303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000242">
        <property type="protein sequence ID" value="OXU29766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG73"/>
    <dbReference type="STRING" id="543379.A0A232FG73"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000009">
        <property type="entry name" value="Trafficking protein particle complex 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="24531" checksum="2F845F5B764B51C4" modified="2017-10-25" version="1">MVIYGVYIVSKSGGLIFNHDHNVPKIEVEKPFNYPLDIKLAYENKKIVVSFGQRDGINVGHVLSAVNGQPVTGRELEDGKDVLDMLENPENFPITLKFCRSKMTTNEKIFLASMFYPLFAIASQLSPEPRCSGIEVLEADTFRLYCYQTLTGVKFMIVAEPSQPGMEILTKKVYELYADYALKNPFYSLEMPIRCELFETHLQSLLEAVEKSGISNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHG6</accession>
    <name>A0A232FHG6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000192">
        <property type="protein sequence ID" value="OXU30122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHG6"/>
    <dbReference type="OrthoDB" id="6606299at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15495" checksum="4EA31B132C938C01" modified="2017-10-25" version="1">MDDQDDMVDANDPEQPQEPQGSGRKRQQDDDDTFVKPGTSRDSIKVQCTNKNALAARQNRERQKKHVEMIENKLHSYETQNKNFKTQVAQQKRFIEILNDQVAYLKWELYTKGPVRQMKEINENLIKIMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI47</accession>
    <name>A0A232FI47_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WASH complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000191">
        <property type="protein sequence ID" value="OXU30129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI47"/>
    <dbReference type="STRING" id="543379.A0A232FI47"/>
    <dbReference type="OrthoDB" id="268027at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015">
        <property type="entry name" value="PROTEIN AD-016-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21531" checksum="7132EF0C95481A1C" modified="2017-10-25" version="1">MSDFNIPIIEPTVDYTKVPPINQKRTIAFINHFIAHTITFLNKFALSCEEKLFDFENKLQRVEASLAILEARLSSIPAVENEPQQAVQTPTAEVEDKSKVEETQQVEVTAEEIDEPDNEVPIEPKVEETETQPISSDPQYAKYFKMVHFGVPKQAVKLKMQQEGLDSSMLDTPNKLVPKPKSTDSDVNAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI93</accession>
    <name>A0A232FI93_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAST kinase-like protein subdomain 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000155">
        <property type="protein sequence ID" value="OXU30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI93"/>
    <dbReference type="STRING" id="543379.A0A232FI93"/>
    <dbReference type="OrthoDB" id="443524at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAST kinase-like protein subdomain 2" evidence="1">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="620" mass="71821" checksum="60D09DB595F46394" modified="2017-10-25" version="1">MDFMVKRLITLSVTIRNLAFSQAQRVNISRFCNTSRLHKDEVNRCNLKAQKEDLMLKTLRQGLSPSNLLNYIDSNKDQMRREHVIAALSSLHYFYRDKCQITTNLDEQIDFTKLCNCLQPQIKQLTPNEVIEALNILQLLNVPSSNIFVMTLLQHIEEYMKDLSFQDMYKLSTVLVQFSPTNFIKSIESSIKSQCFAKISQLDKSDISTLICALCFASKNVEDKAILNFLSDAVENYKEKIELKDALHILKSLCYTNDLPYKFTSIIEHVQKIIIENIDELNPNQILQIIKDISSKISTNHDEFYNETFIDELVQKVIYENWDFTRGSDILSCLNFIRHVQIDLLDYLSAKCYEDPNVFNEESNVIQPLVTGLALADYKPVFWDVMKQPILSQEISKMEHLKLCYFALHLACLECFEPMLLKEAFSTKHIISEEHQQIILRLYQIIKILCPSYGGPWPSKDLLDLVKNSQLNKDYPLLPALEQAIGGNVYIKTNVRTTMEHYIDHVVILNRSGYPIAINSYGSIETKCHNNGITYLEDLTIPPDSQIYLILYAQPEWYARNTQRMLGPYSLFIRTLESMSYTVIPVNGKMWEKMPENEKTLYIMQAIKLKFEDDTISTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIF3</accession>
    <name>A0A232FIF3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000181">
        <property type="protein sequence ID" value="OXU30239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIF3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="206" mass="23989" checksum="FCBB9955D366FC78" modified="2017-10-25" version="1">MPIDYKFRKTVRCYESHSWERSLERSRDGDIFWCCRMLISEMMLFSSTIIGGEEVLRCDDILQAFSSGTYERIESVFRAAARRFPSLYTTQTTKHNEDVNGASTGMILKRTRRYSLEPVHKLAGISTLLLDNSENSHRLFFRRENSEKDTVEIRSRDKQQQPRIGLYFPIQTQAALARPINYVNLSGVHADVFIRVEKNGLLSRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIH1</accession>
    <name>A0A232FIH1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_014303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000179">
        <property type="protein sequence ID" value="OXU30258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIH1"/>
    <dbReference type="STRING" id="543379.A0A232FIH1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="64"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU30258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="473" mass="52476" checksum="A046A9CAB53EDAEB" modified="2017-10-25" version="1">MNASGAKLFVSRQTVLPDGVKAAVLLVKNGKIEAIYPCANDNEINDKLEQHSNVEYEDFGNLLLMPGIVDSHVHVNEPGRSEWEGFWTATKAAAAGGVTTIVDMPLNSIPPTTTVENLKTKAQVARTKAFVDIGFWGGVIPGNQKDLKPLVEAGVVGFKCFLCPSCIEEFPHVNEEDVEKALMELRNLNTVLAFHAECELKDAIDKSKGLVLLITMIYEDPSVYHTYLQTRPEIMEVNAITMITKLCKAYNVRCHIVHLSAAEALGLVREAKKNKLRLTAETCYHYLYLTAEKIPRNATQFKCCPPIRDESNREKLWRALKDGTLDMVVSDHSPCTADLKQVGDFLSAWGGISSVQFGLSVFWTEARKRGFSYQDVVKLLSSAPAELCGLEKKKGALRVGMDADFVVWDPETRIQIEESGILHKNKLTPYLGEKLYGKVFATVVRGNFVYKDGVFSSEPLGQLLLRDDFSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ26</accession>
    <name>A0A232FJ26_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PKD/REJ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000124">
        <property type="protein sequence ID" value="OXU30746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ26"/>
    <dbReference type="STRING" id="543379.A0A232FJ26"/>
    <dbReference type="OrthoDB" id="6381995at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045219">
        <property type="entry name" value="PKAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11861">
        <property type="entry name" value="MELANOCYTE PROTEIN PMEL 17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11861:SF8">
        <property type="entry name" value="PKD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353287" description="PKD/REJ-like domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60232" checksum="9D46281954EC2EFC" modified="2017-10-25" version="1">MRRAAAGHRGRVFLGTAVLALLVWQAEASDADVRLTHDGPAVLGSTITFKAELVDSDGRAPSGSFQYTWRDNAVEQHYYETETTSNTTVYYSVSYPASKYHVGEYTMEVAVCKWGWLSIHCGDYTSRRVYFRVSPLMNGNITIEQSNRTVSTEFVASSEVAKISVNLRKGDLDYITKTATSITTYWFVDCKAYNQTNDFTFVHNFTNPKSFHTIEALVVASFEPPTTTTVAPTTTSTTPSPVPTTPKPSNNTDTNSTTTTTTTTTTTTTTTPTPTPTPTPTPSTTTIAPRNSTVLSNATVPLLANATFPYICNSILDPKPNTTYGYFQREVKIRAPISKLSIEGSTWIQPWNSLSLSISCNGTGPFYKCIEIHLGKYNVTGNETCSQDSDKLETCKFNFEHYFLEPLEYTVLIILGNEVSKEIHPVAVNIYKLTPKPQLSVIVVPVSCSLVAIVLIIFGIAYYVQNRSRFTVEVADFDFGQSTADMEYKTFTERLRDSFNNAVRPGSQHERLLGANSLAHKRTRNTDEDKHREQDENAAYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJH3</accession>
    <name>A0A232FJH3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000131">
        <property type="protein sequence ID" value="OXU30690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJH3"/>
    <dbReference type="OrthoDB" id="7697473at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="13865" checksum="EFC8C31027B0FC5F" modified="2017-10-25" version="1">MPPSRGSNQQPSQPPPTQKNSSTGRARGGRYVLSARAQAVLTWILEDIIEKTLEDARRQAEAAGKQRVELAEHQSALRILRISLTLISQPGCFISADSSDEDSDHFTPGASDACCVFHLSRLYRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJM6</accession>
    <name>A0A232FJM6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Ras GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSAR_002549</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Alberta</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000133">
        <property type="protein sequence ID" value="OXU30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FJM6"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11788">
        <property type="entry name" value="SH3_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14277">
        <property type="entry name" value="UBA_UBP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035652">
        <property type="entry name" value="RasGAP_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022166">
        <property type="entry name" value="UBAP2/Lig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12478">
        <property type="entry name" value="UBAP2-Lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7 16" id="KW-0349">Heme</keyword>
    <keyword evidence="13 16" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 17" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="5 18" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="77"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="246"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="22">
        <location>
            <begin position="372"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="23">
        <location>
            <begin position="451"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="24">
        <location>
            <begin position="620"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="940"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1195"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1247"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1310"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1521"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1570"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1708"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1803"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1897"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="951"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="1026"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1247"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1258"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1318"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1521"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1576"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1588"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1709"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1803"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1822"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1901"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="2411"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OXU30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="27">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2468" mass="273588" checksum="E3FC3042630AD8BF" modified="2017-10-25" version="1">MAEFVRGGPSVSNNAKIENTKKGDSPSTGSEDGGNIEPINDNDFDVFLENIPDDIQDIEEPDHTNNTTFSAPPENQWYHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTGINHFRITAVCGDYYIGGRQFNSLMDLVAYYTHCSDLLKKERLIHPTPPPEPVNDKKRIVAILPYTKMPDTDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGLIFRELVDDLDDSIDPNTVFSWFHPNVTKSEAVDMLVKAGPGSFLVRPSDNSPGDYSLFFHINNQIQRFRIEKKGVRYLMGGRTFECLDAVINRYRKEQIVEGHTLVQAMVTEPDGTVRVNKEVQHAEKIYATLRECREQSGAKKNKGIKMQGYLEKKSEKNKKWKALYFVLVVDASDTHLYLYDNPKRTKPKGLIDLSCAYLYQVHETAPNSETASDWINALKPLCVSQLTRAPKVARLRELRSLQLHIMDAHRLPYKLVPNPFIIVALNNVKVARTKMKTGPHPVWDEEFILEDVPPDVMSFSLTLYNKGKRSKDTEVAELIVELSSLANGEEMDEWYPFAGVTPIGDWGALRLRLRYRHDLAMPPEEYSPLQQLLLDPELHVVKALADVCHLDRIPLANSLLRIFRHEKREADLLKSLNQAEVDKEDETPTLFRAASLTTTLMDLYMNKQSCELNPSKMDSPEDACSNAEFLLQVLDEVTLSIFTSPDMCPKSLRYICCCLQRAVVAKWPHERLVRTRVVSGFIFLRLLCPAILNPKSFNLIAESPSPAATRSLVMVAKCLQNLANLVEFGGKEPYMEVVNPFILKNKERMVVFLDQLSNVSDKPEPECISPRGKCISDIAKDLATLHHICVSHLKELQILSKQQHKSDQLKHTQSDNRNNSKEDVALNERIKQVMELTRRSEDEVIMALHDCDDDLNRAVNDLLEGVSPEWEVKKKKARQTGGPKQNSEQSGVPDSNADWGEDKRSLYTNDGSSRVRGGRGGNHNNRGWRRRENKENEKNSEEGKSDAPHGGSRRGRGVSGRSGRGGRGGGRGLGPRTFANRGKLDAWSGIDATEDWDNEEYTGSLADTKVFTPSTLTTEAAAVPEQPKSEELPSIKPIRSAGLLEHNELPKISGATATAQETVIQEQSHQDIINMPSMHLPHSLDDVNRGSLSAAQSEYFTQLAQANDINLNVSTGQTTFLSVMNSQPQRQTKHRPRVPPPSKIPSTAVEMPGDALNSSISFLDVQFGALEFGSDASITDGTNQEKFNSSRSSPGTSSVESTSITTKTVVNSINSLNVEVAQASPSQKFSTTTKMLRSDNQCIPKEHSINSQSGLTSRSAATQPVDIQKQDLSAQTSLSNSSTYNAATVTYQSPKPSYSTSVTSSNYSSYAPSNQASFSCPTTSSHANSFSGIAPVTQSGYSSPYTQPITTYSQTSSSSSTSGIYNQASTTTQGYQQTTGFTTTPISQYQSQAVTTNASSNSSSYISPGYQNPSTFQSTAQTYQPSNTTFVSSISQGSSVYSNTSQSVYSNTYPSYGSQNQSGSQDHKLSTNKDLQFDNNATATSTSLATTAVSTLGLTSSSVNTSQTKTTMSSTVPKSTVSGLVPSSSSSSSSISGSGTTGNIAPILSHQYIMGQSVPYATFQQPHMYSYEDLQLMQQRMPHMPTTGYYDATLGYQTTGPVTSLGNSRSDALSGVQGVQGVQAVQGQYTSINDARFTRTDSNASPVSSTMSQQSATQHQQPLMNPIPPGYAYFYGGGIMPAGGFQYGTPAIYPQIATAGSAGTTSGAYNTKPGSYGSGYGSGTNYDSLTNSASSGDYKSTASGYTSSQTGKNGSSSANTNTAGTSTDINTTMYTKGHVTLNKVNSYDKQTFHSATPPPFGLTNNQNANVISGYGTHLFIPTLPHQLHQPLHQDSGNSSGQRTNTNSQNKAQVKPGYSTSYWAGDMNMMESLAPMLHTKLFWLTAVVTLIWVHFKFVIYTYWKRKGIPHDEPVVPFGSTLPIFLGKSSMGNLVKQKYQKSKKYPLYGIYMFHQPMLLINDPDLVRIILIKEFNKFRDRGLYFNEKVDPLSGHLFLLPGERWRKLRAKLTPTFTSGKLKQMFPLLMEIGDELIKVCEKIIQTDSVVEFKDLNARYTVDTISSIAFGFNCKSLDNPNNEFKRYGSMVFDQSPIRNALGTFAPVVLDTLRIPLIRRVIIDFFSQTFKDMVDHRHSNKIVRKDFINLLMQLMDKGVLEEDETSQKSNDHAKAAESLGNMFEIAGLIDNEKISMVEAQAQAFVFFLAGFETTSSTITYCLYELALNPHIQEKLQAEIDEHLAKPGGMTYDRIMNELEYLHMVFSETLRKHPSVPILNRLCIEDCDLPNTNFRIKKGTGVMISVSGMQRDPNIYPDPDKFDPLRFTKENIASRSPYVYLPFGDGPRVCIGTRFGILQSKIALIALLAKYKFSVCDKTSIPINYSKRSFTQSPEGGVYLRMEKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKK1</accession>
    <name>A0A232FKK1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000099">
        <property type="protein sequence ID" value="OXU30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKK1"/>
    <dbReference type="STRING" id="543379.A0A232FKK1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF154">
        <property type="entry name" value="FI04917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="610" mass="68106" checksum="B92FA2933B49E925" modified="2017-10-25" version="1">MTWHPANITEGCFTNYFISSCQPSFLTFLTFLSQYLGHSRDDKLRSARALDNEYDFIIVGAGSAGCVVANRLTEIKNWKILLLEAGDEQPVVTEIPGLLGVLADSTIASSYDYQRKGEVCKLSPYLCIIPRGKVMGGSSSINAMIYNRGIKRDYDDWEKQGNPGWNWDNVLHYFKKSENLKSKIPAGDATNHGIGGYLSVELREPEKYAEIIHNAWKETGLKEVDYNSGENLGTARMQFTLKDGIRQSANSAFIRPIRGVRSNLTVRTKIQVTKVIIHPKSKRAIGVEYVVPGTKLTKKVFANKEVILSAGTYESPKLLMLSGIGPVDHLNEAGIKVVKSLSVGKNYHDHIGLSSYEFLINDFQNFNDANKYVEDIKNFMQNNEGSYKMFGGILDNTAYLQTEYETRPGIPDIEMFGLNKVDIVNGVDGNATYCGLIYYDTYVMFTTLTRPDSRGWLTLNITDPTFSNPIIYPNLFSNEKDLKTLVAGMKLWKRVIETESFKKSGLIAVRTQAPACEKFATDDDKFFHCAAKNYVQAFYHPVGTCKMGPSTDPEAVVDSRLRVHGIEGLRVIDASIIPVIIRGNTNAPTIMIAEKASDLIKEDWNSSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLA3</accession>
    <name>A0A232FLA3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Helicase POLQ-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_014936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLA3"/>
    <dbReference type="STRING" id="543379.A0A232FLA3"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF12">
        <property type="entry name" value="HELICASE POLQ-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="200"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="409"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU31363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="110183" checksum="D3854C15D4A065ED" modified="2017-10-25" version="1">MTPFNEEDWNTTFNKSELPLTPESAARTNSDCTDTSEENQLKGLLSMDDSFMKDVELDISCAQVCNKFEDFNHKEDEDSPHYSWFDKDLNKSRFLTDKFTQNLNNDDVHWKIVTPKKNQLELNDSINDLNESINFLKHKLFASESDNIIPFKRRHTESNKNCVSSYKYPFYGLPDKVKNLIKQHKGIDKLYDWQDECLNMKALNERKNLIYALPTSGGKTLVAEILMLREVICNKKNAIFVLPFVALVQEKIQSLTPFALALNFLIEEYAAEKGHYPPKKRRKKNSIYICTIEKAQSIVNCLIELGRLNEIGIIVIDELHLLGANGGRGATLECLLTKVMHVNSNVHIVGMSATIGNLKEISDYLNAELYTQNFRPVAIKEYVKCEGDIWLIDTREENIFTDKKTIKYNYSQKALQVDPDFLGGLVMDVAPKDSCLIFCSSKKNCENVAVLLTQVLLKSVEVHKAAEKIKLLNALETETGSICPVLKKTIKFGVAYHHSGLTAEERRLLEEAFRSGILCVICCTSTLAAGVNLPARRVILRSPYVGTEFLNMSRYKQMIGRAGRAGISEIGESILICTKRDTEKVHELLRSKMDDSISTLHIEKDRGVNNLIISSVLLSIATTRADILNIMSKTLLKVQEDRLGISVKEVTDKALTALLKSGILRVKQKQTKEVFSKLDSTVIFPSQMDDDVTTSVKKEKKKYITLVNNTELELCPLGRAAMKGSIDLQTAHTLYEDLKKAQANLVLVDYLHLLYLITPYDVACQVKPVGTVYYDVMMSLPPHQMKVARLLGINEAAVDRLRAGITPKNVDQKIVQRFYVTLMLNELWNRRSIYFVADKYQVNRGTIQNLLSLASSFSSSVVRFCDELDEFWAFKDLLSTFGQKLTYCCASELEPLMDLPYVKIGRAKQLYKAGFKSLQLIAKAKPEDMMDKIEHLPRRVVSQIISSAKLLLLEKVENLRDEVEEVLDGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLB3</accession>
    <name>A0A232FLB3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_014946</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLB3"/>
    <dbReference type="STRING" id="543379.A0A232FLB3"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046015">
        <property type="term" value="P:regulation of transcription by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000068">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU31373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="354" mass="40772" checksum="5E31373E296530C8" modified="2017-10-25" version="1">MSKKRKGKNEQKQMSKPKQTNLKGVNKHEKTKFKHTAKQSKIKNKQNIKNNVLSNSKSKQNIKDNVMSKSKNKNNIKGNAASKANSKQNIKDVKITKKDKLLKRLNVNRLSSMLQEKEKTTDEMKKKKVPEAPLSLRERMMAKLKASRFRYLNEQLYNSESSQSKKYFEEDPDAFYAYHEGYKQQVDRWPMNPLDVIIESIKKMPKEHVIADFGCGEAKLADSVPQTVHSFDLVAVNDKVKACDMANTPLLTGRVNVAVFCLSLMGTNLGDYLLEANRVLAKDGILKIAEVESRFEKIDDFVKLMTSYGFVNTWKDLSNNIFYFMDFKKTKDVLKKDVKKLPALTLRPCLYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLH7</accession>
    <name>A0A232FLH7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLH7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="205" mass="23826" checksum="EF3ECC1B0BC2D84F" modified="2017-10-25" version="1">MREMHKISIQVSEHRYIQTNGDFDETSIRYRADTMNEEDVEKCSMDGSRMNTNFHGSHFEMTEIDKLRRIVVLSHLLTATLSQMTKTLNMFWTNIAMMNVKYFLGFFQYYHKFHTSFCYAVAVYVQVFLSTNPTSFGSKCRKRAESVRVNGFLKSFCHIALLTFIIKNRVMLCSTSLLVVKNGRGFGSNNKDTLMNRCIVFPLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLK1</accession>
    <name>A0A232FLK1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_013248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000050">
        <property type="protein sequence ID" value="OXU31532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FLK1"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="693"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="807"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="965"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1058"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1092"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1118"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1266"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1357"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1520"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1583"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1612"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1638"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2058"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1648"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1662"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1693"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1705"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1717"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1756"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1785"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1852"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1894"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1959"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2067"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2082"/>
            <end position="2128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2134" mass="243271" checksum="E6AC13CF7D046F0D" modified="2017-10-25" version="1">MYNLENFYDFRTACVNAVAMLERCLPPDATKVEIKQENNDSSEPYSELRMELLKDKDTGNSSSGGMSMLISEAPVVNPNAALGTPPRLKSDGEPDNEEIGDAAAGDERLEEHDKSDEYEMDMETNPSDFLEMSALVPEEESVLPAQQQNAGVFQHRNEQHEVYVCSLCNKAFSSKGHLSLHARIHVGAGDVIGEKVITDDHTSYKRPYQCDLCNKSYSTAKHRWGHVSTTHRGHPAVTCGYCSRIYSTRTNLEEHIKSRHAGLPPPPEIPTPYVQQDSRHQCKTCPKMYTNITDLNKHSRVCLGEQQRKEQQSNNSFNPQNFGKKNAMCKCEFLFTLFFILWSEATIDSALDFSYDFSVAAKLKNALDTTSDMSSIDSDYENKDYRSAEAKLAKNPQLTILKQALIKGDSAKKEYEERQKMLSKSKKQANATNKGVDPDAKRWYCEVCPLNFATVDELRQHEKSHDADKPYICILCAKDFVLKSSLSRHILSSHGVDPTPLVESDNCLKKSVQEANMQPPLIKEEQNVTKENSSSPFSADNMENDEDEHENGKDNMLEIETVFVCEICTRDFTDRASLWLHIRATHKESAAFACGVCLKICSDNAQLLNHVNMYHGGNKLLMSEQRRYSCTVCGRQHDSRKKLITHVSIHNIDPSYDPANFVQLNTNYYNENVNSNEGGNELIMDCDDESEKADCYICYKRFPNEDQLIRHQRNAHKSEQLVEVGGNGGVPGQNGTGNRAQYHLFFVCELCGSSHPSKWERWLHVSSMHGNELAIRCERDDCAKIFATKALRNEHAQHHQLQGSSPNTCEICGKLWGSRVDYWKHVMGVHADTVPLICGVCLKVFPDVMQLSQHVKLKHWPLTNGDFSCDICGRPYSNKSKMSRHRKIHGLDGEVYNPSAANSSLIINDASSEMAGLPMPLSLDNGMPQPIEPVSLDLSCEMCGDLKFNSLEDLGNHRRMAHSLFPCDLCNKCYGRTSHLWKHVNRVHKGHEDVTCRFCLKTSASKDHLAAHIAKIHRYEPDVKTEMEIKRDNVVYKNSSSNYYHMAAAQSPEEDGLHFCEKCNKSFHKRYLLRRHMKGCQNYRKDPAALLTRCRACERIFKDRASLQKHIENHHSSYECHLCKETITSKLGIMTHNRMHHMHHPDLTCELEHCRKLFRTKEDLELHRKDHQHLGTPNVCDFCGDTVENKLKLKMHILSLHRNEIGVSCGVCLIPMKDPKDLKKHVEDVHESILLRPNTCQVCGKQYASKWKAFDHTKKCHGKVFRTCKQCLAVFTSDEDLRYHYEHIHNIPKDQLDAFQYRLEVAGNKMDDYDLGALEVVVKEEPEDLDFDCDAFDEDTTGNSNDSKRRRSITDTFDCEMCPEIFLNHELLSSHYRNVHNTDPERMFKRIKLEASSSKPKKKMRERENYECKNCQKQFCTKTLYLGHVNVCTRKSVPTSILEAHLKNNNQIKREEPEPIICETNLNIPDFNLFEGINMQLSGQKPVPSLMPLGGHSSKSSKYSRKDSRKVYDESTNTECTCEVCGKQWPAKKHLWQHLIRFHRAEAAVTCGVCLKLCATYEDLSEHLKNVHPSILSTAGNNFTCKICGRYHNARSKLLLHMSIHIDCKNNFMCQRCNISFDSEEKLNEHVASCVVVPSQSEAGEEPIEVKEESEEKGSLIGDEEDETQENEVESGDENSDNADSSSDKSNDSDSSNSNSNSDSSSDDDSDDDEEDGRSQNVDKDSNSSDDSDNAEEIQPQVEVKHPMMEETMSLGEEDDEEDGMSESENDDYLKKQQEAQQQHGIEDRYEIQQKEAMLVNYSDDEGPPALSPMMPQAINEGSAPNEDSQEELTNRHMTLNESLNVKKEKSDDSEDNSSDEEAQESGDDEVQQAELVDPNAAFHADNNSRSSNEGEEEQEEGEEQEIEEEQEEEEHEQEQEQEEEEVEEEEEEEDEEEEEEEEEEGQEEGQELEEQEHEMDVHEAQEHEVQEVEEEEEDGNVEHGMNEHEVLEVDENEMHNLNGTVLMLANDADGNQILIERNMADLENDDSVHDMAQYVFQDGTGFALEDYEAIVENQGEEEEEGQEHHGFEMEIGNAHEEEVEDQEQEEEETEERGEEVEEMEEGEEMEEATEEHEEVEENDDEELSSSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN71</accession>
    <name>A0A232FN71_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000011">
        <property type="protein sequence ID" value="OXU32023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN71"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624356" description="Receptor ligand binding region domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16284" checksum="C097B0AEBBECDDD0" modified="2017-10-25" version="1" fragment="single">MARCWLHQRWWWLLLVLFAGLSRLGYCQKPSATAAAAAGTTTTTTGPTPQAAITSPRIVVFLREQCDGELNSTELLQELQRGYASAIGMVSKAETCEVRSWGLEALVQALSQKTTKALVAQLDYNTCEVAAKLAHLWNKSLITWTCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNB2</accession>
    <name>A0A232FNB2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000022">
        <property type="protein sequence ID" value="OXU31857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNB2"/>
    <dbReference type="STRING" id="543379.A0A232FNB2"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF39">
        <property type="entry name" value="IONOTROPIC RECEPTOR 56A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013348291" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1267" mass="147636" checksum="BA044BED8303BE89" modified="2017-10-25" version="1">MKLQNVLLKLFFFTCVQVTHGHFDNFKNEDELSNSMIDILRYCSAPNDSIVLSGNWDYKDVIKLNKVFNFSLPLFLIGLREDFHFKKHKRLKNIYNMTDAVIKKKRYPGANFLIMVHSNSNLSQALNMLRESVLWNHEGVFLIVCKNFEDRCRTAGSFLYLAWSFHILSVTLLCYDDDDVLQVYTFNPFTRLAPKFWNIVEGDREVNDTRWTLLKKSVNDLVNVSYSSICENLNFDKTKNLHGFTLKMGAYVHPKLLSYDPKKTGLRRFGGVNGEISRAIWSHLNATASINFYSKSGFINDNGSLQSSLRDLLKGKIEISMNMNLMREFWKLQSYPHETAGFCMVSRKDSFPCVSSHYYNVFQPGASLFLGVICLSLAVILKYLTNRSLHFAALELVRMIVMIPTLSTPRNPIIKSLFVYFALLMMLLNTYSQSRLTSFDVVPRTNPTIDTDVDLIRSNLMIYGTLSYNELFGTDPRLKDRYRIGKYPECVERLMRGSRIICIAGCYEAKFNAYEGDVLHVSDAIRQFYMSFAVNEYWPFYSKFNEVLRRLSEAGFIRLYRQREAESFLRDLSSKNKDYRGFFQPFWYLWIYGMVVAVVVFSVEMIFYEVKKRLEVLEEIIYLKKYDVARYRLIVRIAKGFALKQVQSMNIGYYFIQVFVLKLLILESLQQKLENNYGRLNRTNELMNTMMSIFEKCLKNESARNVVIAGDDTILIEMISRLVPIRLIKCHENLTEFSDQGEPGNNFIIYASSSLVLSTTLQALKNSIWWNYEGFFLLINQKFGGCEMASTLLHLVWTFNVLSTILLCFNFNRRLEFYTFNPFADFAPKLWRETVSDYGKGKNPWTLFKTSSLSFSHPRICQNLIFDKTRTLKGYTINMGAYVHSFLLEYNPNKTGLDRFGGVNGDITRTVCNHLNATANVKFYLSMGFIDDHGMYQSFLKDLHHRNLDFAMNMNLMRPMWKKQTYPHETSGFCMVSLKDPVTFLEKITLVFPAQTWMWLVIIFIVLIFALKILLKQSLFLATFEFLRMFLNTTISRLSPQDSGRRLFYLVIVVMTMIINAIFQTRLSSINVSTRSHRYIDTMSDLIKSNLFVYGTLSYKELFSDQTVLRHRYQLSEYPDCINRLKRNEQVICLPGCIEARFGAYEGNKFHISSKELMLFSMVFSTREDWPLLSRFNEILRKMSEAGLISFFRRIEARHFKHNPDDRQRAPKISVESLTFGFVLLLAGLSLGIVCLIIEIVTIFAKKYSLKKSLYAKKLLFNKVFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNH5</accession>
    <name>A0A232FNH5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000009">
        <property type="protein sequence ID" value="OXU32070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNH5"/>
    <dbReference type="STRING" id="543379.A0A232FNH5"/>
    <dbReference type="OrthoDB" id="366284at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052815">
        <property type="entry name" value="PDCD2-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="325"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU32070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="431" mass="48227" checksum="130CFF0E9113674B" modified="2017-10-25" version="1">MAQDVRTKVYLGYEDEYVTEKHRSLLNFTTNKIGGKPDWHNDQMTLIAPQCRLCGLHQLLALQIYAPLDNSKYHRTLYIFACMNPNCWNQNESWTCLRVQSLEQVASTDSLSSSCATVQTSATSWLADADDWGDNWNDNVSERNGNNLMLNDPNKFSLSAQNTNYEEELKADFSELQVDDPNANSPTSVESPVGVGAVGRLDSPHASAEIEGEESEVVCIDTPTQPRCDLINLLQEVTPLPVQHTESKAGKSLLNFTEIFISVDEESLGGGEVPQHVRDLFLEYQRSNGADVTAGQDGETSDDSKAGYDGGGMEKYEKGIPKHGDEMFHNFVSRIQKNPGQILRYARDNAAPLLLYPMGGCIGRCRHCGDEMTFELQILPTLIPKLKLNTRSDRHFQLEYGTILVFTCVRSCWSATDSYREEHVIVQAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED72</accession>
    <name>A0A232ED72_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01008088">
        <property type="protein sequence ID" value="OXU16288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED72"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="8858" checksum="B42E553F5428621D" modified="2017-10-25" version="1" fragment="single">FCERYARRGCATVSCGLVAIARGSSRFPEDDAEPPGAVTSNRHDGSADITVTQGFCWVALTLCPRVMLFPSVPESHLSGSVADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDK5</accession>
    <name>A0A232EDK5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006262">
        <property type="protein sequence ID" value="OXU16431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDK5"/>
    <dbReference type="OrthoDB" id="7555155at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="10126" checksum="C03AD1585D5DF68F" modified="2017-10-25" version="1">MKPPFDWFSMRHGDLVLLRVPKQSNLIERKIAKFFHLYYGPYRVLCSFNENAYELVDIDDPQKLVGRYNRADLRLYVRSENNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDL2</accession>
    <name>A0A232EDL2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006269">
        <property type="protein sequence ID" value="OXU16418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDL2"/>
    <dbReference type="STRING" id="543379.A0A232EDL2"/>
    <dbReference type="OrthoDB" id="8014450at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="155" mass="18069" checksum="9B26572C91FE3EDF" modified="2017-10-25" version="1">MEQIRKVQQENMKQYNKKRIPPRKYKYGDIVSIRRSQLNPGLKLRVKFLGPYIVTKVNKHDRYEIEALTVFDGPANTSTEAQNMKPWRGFKDDLEEYDDENDSSEEDKEKNQDEEVETNSDIEDEGSQEDEVETNSQAEEDEANSDIEDADSEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDV0</accession>
    <name>A0A232EDV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005899">
        <property type="protein sequence ID" value="OXU16525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDV0"/>
    <dbReference type="STRING" id="543379.A0A232EDV0"/>
    <dbReference type="OrthoDB" id="7699669at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="456"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="753" mass="83575" checksum="D183DD0C5228800B" modified="2017-10-25" version="1">MPASPDAFNAHFIGVSGPVIQAPLPVTRPSSDSVLDFHRVDAADVLEALTSATSMAQGADSISLRHLRDCVPIILNPLANIFDSSLRAGYFPVEWKHALVRPLPKRSLAENVEDFRPVSIFKAPAKLLESVALAQINEFVTQNNILDDYQSGFHKGHSTDTAMIGIVDDLRLAVNNEHVSVVVGIDFSRAFDLRISSILLCERVTFLSCGNALVRPLPKRSLAENVEDFRPVIILKAPAKLLESVALAQINEFVTQNNILDDYQSGFRKGHSTDTAVIRIVDDLRLAVNNEHVSVVVGIDFSRAFDLVNIDLLVCKLYHLGFSDRSCSWVRSYLSDRSQAVVFPNGDLSAPLIRNSGAPQGSLPGPLFFSLFINDLPRVLESCKYQLYAEDFVIYLEGSFRELDNTIEKLNRDLSNIVNWAACNGLIINATKTQAMWVGSRGFISRLREESPPAIVFSGTGYFPVEWKHALVRPLPKRSLAENVEDFRPVSILKAPAKLLESVALAQINEFVTQNNILDDYQSGFHKGHSTDTAMIGIVDDLRLAVNNEHVSVLVGIDFSRAFDLVNIDLLVCKLYHLGFLDRSCSWVRSYLSDRSQAVVFPNGDLSAQLIRNSGVPQGSLPGPLFFSLFINDLPRVLESCKYQLYADDFVIYLEGSFRELDNIIQKMNRDLSNIVNWAACNGLIINATKTQAMWVGSRGFISRLREESPPAIVFSGSAIIPSDSLKILGVTIDSTLSWRSMQRHIKEMLRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDX6</accession>
    <name>A0A232EDX6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005801">
        <property type="protein sequence ID" value="OXU16555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDX6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="264" mass="30017" checksum="1A9B2530DC1A2221" modified="2017-10-25" version="1">MDVIMEVIFSAPKLQNVLDEISRCGVDHRWINIRKSFARDTKNGKKFYLASDLQFLKKHIKHLENASCKSKPPKQSIKEEDNDEFHPEADDENLKFQDVLRCQLQSKQQTNVSQNSITKNENDSLLLNSNQNDEVIKPQENISAFTLALSKIQNPKSDCSSTPKNNVLTGITQSSKKPATSTVHAVMTKETTEITVPEQDEFAKRKQAETKINLQNKVSKKKIMMNSAADDENLNFQDVLRCQLQSKHTNVSQNLITKNENDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE21</accession>
    <name>A0A232EE21_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005673">
        <property type="protein sequence ID" value="OXU16595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE21"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="601" mass="68355" checksum="BD4446FD1080D2D9" modified="2017-10-25" version="1" fragment="single">MTLIKDGKDLVDLPVIECLSDTSRLLSDIHRDESIIRRSLVASNINPTLKEAVSQTTCNEWLFGEKLDEIVKTAKAFDATAKDLRATAKNTSSRGSKNFNNPPCQRWKDRQQKTSGGYRTDKPYRRQQAQMTLIKDGKDFVDLPVIECLSDTSRLLSDIQPDESIIRRSLVASNINPTLKEARFTVFSLPFTDSDSYSPSASLKRTFEERTFVPPLHSELVLRCKDVIEHGLPEEEKANLLKKYPPPENCLFLDPPKLNAETKRIAQPTVISRDDRIFGKQRKIAAALSAVAKAQMTLIKDGKDFVDLPVIECLSDTSRLLSDIQPDESIIRLAKAQMTLIKDGKDLVDLPVIECLSDTSRLLSDIHRDESIIRRSLVASNINPTLKEAVSQTTCNEWLFGEKLDEIVKTAKAFDATAKDLRATAKNTSSRGSKNFNNPPCQRWKDRQQKTSGCLRNVSITKMSSEKFGFIINYKRKLVPKQKCTYLGFICDAIRLTIQLPDEKRKKVTRIANLERIKILKFERFLVSCCTAVEYGYLYTKISERATYLVLEANRNNYEAKMIITTEIIKELRLWKYLDKPICRIRNSAYDLEVYSDASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEF4</accession>
    <name>A0A232EEF4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005358">
        <property type="protein sequence ID" value="OXU16727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEF4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="29" mass="3306" checksum="DEF216EC969A9B2C" modified="2017-10-25" version="1">MAIFQQIKMAYKTVSHGTVSMLERGFALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG55</accession>
    <name>A0A232EG55_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004862">
        <property type="protein sequence ID" value="OXU17327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG55"/>
    <dbReference type="STRING" id="543379.A0A232EG55"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU17327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="386" mass="43485" checksum="573B64747431A35F" modified="2017-10-25" version="1">MTTPELIRKEGYPAEAHVVLTDDGYLLTMHRIPSAAGPAVFLQHGLLASSSDWVIAGRGKGLAFILAERGYDVWLGNARGNTYSRSHVRYSTSDPRFWNFSWHEMANHDLPAEISYIAGLKKARLTYIGHSMGTTMFFAMAIDRPESAAKIEAMFALAPVAFMNHLKSPVRLLAPFLREIELIVRYLGEGQFLPQNAILKFLARYGCDIDVTEEKICANSLFVICGFDASQFNYVIIMRPSPRRLIAQRSCSAPQTLMPVILSHSPAGASTKTIVHYGQEISSGRFQRYDYGPEGNLAMYNSTRPPDYDLSKLSVPVALFWSENDWLASPVDVRRLYDRLPRKILSYKVDYPKFNHLDFLWALDAPKLVYAKLLSAMNASNVYNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG84</accession>
    <name>A0A232EG84_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004836">
        <property type="protein sequence ID" value="OXU17357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG84"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11229" checksum="86ACA3087529D7AB" modified="2017-10-25" version="1">MNIGNLWICTIDQRGASDPLDALQAKWLEPRVQGSGLPDLVSRHKSRPLSTIPELLAVELPDSTILRVRLTDCTFKIPDGLTLFGQTTEHKSEADYAGKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGL5</accession>
    <name>A0A232EGL5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004738">
        <property type="protein sequence ID" value="OXU17491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGL5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="12569" checksum="604D2D313E8AAA1F" modified="2017-10-25" version="1" fragment="single">MKEDDLKNIRNEIAENYNQYFTSTEIQQKFKYLRDIFVKSDLKIQNKEHLTYVEKCMYQRLFFLKHHINHKRGNEVSKYETMSSIKCTESAFDATLNEKKGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI16</accession>
    <name>A0A232EI16_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004391">
        <property type="protein sequence ID" value="OXU17958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI16"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="8903" checksum="33C67098B12D1A46" modified="2017-10-25" version="1">MELIFLTLNLTFKGNTHTPNQKHILVNKTETRTSVTLKVIKVSPLVSHCSECLIKVSPLASHCSGCLIKARPHTGEPYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ76</accession>
    <name>A0A232EJ76_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004071">
        <property type="protein sequence ID" value="OXU18416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ76"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="136" mass="15498" checksum="D01B5A472FFC185D" modified="2017-10-25" version="1">MGINMAVRHNYNQSAFDSCWSLTNASKMNSKSYTPSSSTSPVSDLARNLKKNMHIKSPSPTEKSRKIKRRVNQICNQISKIKLSSPPQQQQQLQPNMNKHELDSFCQATTVKKGSKRALEHLETLAPRNVRRKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKH2</accession>
    <name>A0A232EKH2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003810">
        <property type="protein sequence ID" value="OXU18822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKH2"/>
    <dbReference type="STRING" id="543379.A0A232EKH2"/>
    <dbReference type="OrthoDB" id="7692176at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="178" mass="20320" checksum="46C8DC6DA316D830" modified="2017-10-25" version="1">MHEQVYKMLHAGIIRRSKSNWSSSVVMVLKSDGSFRFCVDYRKVNAIPLTERSIPITAFTVRGLGLFKFVRMPYGLAGGPATFQMLANKLITPEMESFAFAYLDDIIIETDTFSDHIKWLTLILKRINKAGLTINRKKSKICMSEVRYIGVLMNREGCRPNSEQNHPIVEYPASKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKX4</accession>
    <name>A0A232EKX4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003676">
        <property type="protein sequence ID" value="OXU19014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EKX4"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000017">
        <property type="entry name" value="Adenylate cyclase type 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305:SF28">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305">
        <property type="entry name" value="TESTICULAR SOLUBLE ADENYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="5">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1572" mass="178056" checksum="260956B169CF45FF" modified="2017-10-25" version="1" fragment="single">KLAIASGKTYFTSIGDAATASYYIITGKPVWEVKFAEGLCRGGDILVAPSCWQWVNPNEYIYETLPDGVHTLIVSLSVLWDNAKDSYTDDNVSSSSSSSNSDISNSSSSNDPSLTSSLFYRFSAMNEKSSENTTDYSLRLKVIKAAKAKINNELRSYIQRPVIRSVEMDEPLEYLTEIRQVVIVFVNIITEEMNRKTLIKLVNAAFLFVCSIVGEMQGCVNKTSLFDKDLIFLCIFGLRGDKHELESQIGLRCASKLRRGLVKFQHVRSVTVGVTTGMTYCGVVGHVLRREYTVIGMAVNKAARLMCAYVDKVVCDRESFLLSHLEAKHFILQEAKHLKGITNVGPVYEFSEQMTSSDHELSVNKYPILGRDAELETFYKMLQRLLGTSEVQENTDQDDEHKTNILIIRGEPRTGKTRLVEEMSHITPNHVPVNYISLAPHDNQLPYVLLRLIFYVPLEVSEDTPGREKQKKLSSCFTENDRSNLCSLNHVFNVNFKMAPEYSKLDGRARRKNLKKLLAHLTRKCFNVLWVIIIDDAELADNESISLFRTVAKLKNVFFVLTYGNKLSKAYTIPSRIANDARIIDLSGLDKWYHAALACQVMNVLAIPADLEKAIQERSSGNPGWIESYLISLLQSAGVVIKSTTRKQIIEMGLVAPSTNMLKSYDQLGFQMVNHSALPLHTPERAIAITYGKCISRDSRTDSGNDGEYEDESYCNVCTLTSNFVLEDIYTDATIDTILLKLYDSLTPLDQLLLKCAAVLGEIVDRKMLEKLMQGTPERDIGISLVKLFELRIIGCAVGDFSRSPGPAMLFKRVHDPNLNIQVRCGCRGIEVPEALSDLPNYASCGLMRFKLNMFRETTYRLLTENQKVEFHSKALRYLQQNTRRCASCGGGQFSRLLGESALNEIGMGKGKRAESASNELRSSLASETEEAIRDFNAARAENTKADESSSSLSLFQMCRPIEKSPTRTFSSQDFTDCECDLRLLTAYTHVMEHCRGIGVKTLLLVAILEFVEVCLSTLNIPQATKLLAEADELVDTIYNTAEDELIVLPYLKGKIQTLRGRCFLESGLIAEAMKCFEATTRIMHYSFPTNSILIKLKSVYLLEQQRLALTCLRSFKVGVIDAADAANYNDQFASCLAQMFIVYRLKGMLEHARLAAIWGLNAALESSKDFFVLCTSYANMMITAHNYRYTSIIPSLETDAINLCNERKDSIELEELNAVAELYTRIFFSRWLRGLTEEASSIGFIAARLAHAIRSVNLKLIILPRLVQLLISKCRYGEAVSMLQELGILYTSQSHNKNTFAYHIAEFISHNDMDQSGRTWYCALCMDLLLESGISVLTLTDCEQFYQQESSKIMNLRDSEAAKRFFTCMWLWRVSRSYSFFFLNHSFDDNSRRYVRVGDWEAAAVWRSRKCDDSLLDEYTVTAAVSVLKKLEGLIICYVFKLDNKNARDALRVLSDIKETFQVIENLRKVVKIVQPRYLLMKAYYKMARFRTKSGLELLQKSKSLSKEIGTPMILNWADHCEKSWTGSLSLIQQDFWREQCAMDRRVDWHEVDIQNRKLLPYTLPLPKIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL36</accession>
    <name>A0A232EL36_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003671">
        <property type="protein sequence ID" value="OXU19028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL36"/>
    <dbReference type="OrthoDB" id="7698091at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="355" mass="40169" checksum="47F3F0338FC37F21" modified="2017-10-25" version="1">MPSCSYRNCQNSSKKKFKMNSFPRHNPILMAKWIKNMDVKDWKHHQSAVLCEAHFEPHMWEKVRVDGTKKLKCDAVPTIFGDRIVKETKVLGIPHTNLSNDVSQPAVINIASTTGSTDSLATLKLLSSDDTKETNSANSVQVEVYNLNSQGKVVQSTLTSILKPQDILNQLRMANSKTPIIIPGPSNIHKAKVQTTDSESVNDTTEIKESESDSDTSTAQTTGIILNKAEAKKIADERFEKMDKLLLKQLKLNDTLRKKLVSVNHKLQQLAKEEKIDHKTYLTDVFTDDQIRALELRHNNPKSVTSWSHKTMMKAIKLKQECGTRGYEELLRQKMPLPSIRTISRWCTARNIPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELG7</accession>
    <name>A0A232ELG7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003555">
        <property type="protein sequence ID" value="OXU19206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELG7"/>
    <dbReference type="OrthoDB" id="6062130at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="15283" checksum="8930BC47B8442B42" modified="2017-10-25" version="1">MRFSDEIIHNLLVGELMLDLKDIPNTCLSDSFLDTEVDINFLKFFFKKAAFEQFYNKIQERKLDQNFTYVKCENAVVTDCIRCDRCLLWRHYLCVNLKHPNKALLSKISIGTVLSVFLLLSCLEFYPNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM25</accession>
    <name>A0A232EM25_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003467">
        <property type="protein sequence ID" value="OXU19362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM25"/>
    <dbReference type="STRING" id="543379.A0A232EM25"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF9">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="74458" checksum="F9E72747ADC51FE2" modified="2017-10-25" version="1">MSDIEGEDEFQDAQEDIPPPSTMDLDTSILESKQAIHYFFNNDFENARKILEPWADSSMYHSLGNSVFAFLEATLTFERKHIEKASEALKQCMAVCSKHRRHTTTMQNIGKMVKKTNYDSYTIVEIHAELCYAESLLLKAMLTFVEDETLVSFVKAGLKIRTCFLLYKECLAILNTRKWESETHRIHFESGVRMGLGTFNLMVSLLPGRVIKLLEFIGFSGDMVELLCFSCGSMNSAVKYGLGQLQAGYEERRGLRQVLCAMTLLSYNLIITFFLSHSDGDLEWCEKALDEELSLYPEGVWFLFLKAKLEFTRGNLDESIEWYTKSWKSQQVWPQFHHLCFWELMWAHCVKQEWQPALGYAETLSRESNWSRTIYLYQQAAIMIMMKPSSRSEERLKIDQLMTQAPTYKQRIAGKSLPMEKFVIKKAERYFAQKKNLVLPVFELMYIWNLFKILGKHRDKLMAVFKTVEEEEAVLRTSPKSQFHADNEALILVLKGACLRQMKLYLQAQDCLTRVLKLDKEIQEDTYLLPFAAVELAMLARDQGNTQVAISLLEDAKVVIVLRKLVFSPHRKNFTGYSLESRLHFRIHSGLMELNGKKSEEILEKRMQRTALNDSPIMESSMDLPGPSSIRSAAYKVPNNCPVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMR6</accession>
    <name>A0A232EMR6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003335">
        <property type="protein sequence ID" value="OXU19602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMR6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="344" mass="39921" checksum="AB235912D2F5D9BA" modified="2017-10-25" version="1">MCVKNLILRQLEEKCSLLKSRMERTSRLIQQHRDTYAELYEEREEVKRALDIMKSLPSIGPINHHIPKLGDVCEVQLVRVSGVRAHVWYRTIINTSLNFSPSSLLFLLGPTDNCLDYSRQFQVGRSYSKMSVKSLVLRQLEEKCSLLKSRMERTSRLIQQHRDTYAELYEEREEVKRALDIMKSLPSIGPINHHIPKLGDVCEVCARVMKQMTIRTRWTYCTECRARRCTTCSRRKLWCCSVGAEKKKATEEVAEEVMQQQEVKLVHTDEDTTMVDFVKIGEQQEEAEMQQEEAELQQEGDEVDKDIDIGEEFFQFDSPASPDNIADRGKLVMFTMDKSATTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMW3</accession>
    <name>A0A232EMW3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003265">
        <property type="protein sequence ID" value="OXU19714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMW3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646930" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18379" checksum="3B9B0F658A574354" modified="2017-10-25" version="1" fragment="single">MHQGINNIGLHFMLSLRLGFLTLPVSAGARGGSPVLTEIASLVEISPMRPTRNPGSLTVMPVAGDSTRRLRIAPASGHCDRGFRPPIIALQRAFESRLFSRFSGNQGIETTTTRFREFPPVDRHLGRVASVRRTPPPFWTTEVLISRRSTKESRFEAQKDTRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN70</accession>
    <name>A0A232EN70_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reversion-inducing cysteine-rich protein with Kazal motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003195">
        <property type="protein sequence ID" value="OXU19823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EN70"/>
    <dbReference type="OrthoDB" id="5956770at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056978">
        <property type="entry name" value="CC4_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056979">
        <property type="entry name" value="FZ_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039016">
        <property type="entry name" value="RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055110">
        <property type="entry name" value="RECK-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487:SF3">
        <property type="entry name" value="REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23332">
        <property type="entry name" value="CC4_RECK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23298">
        <property type="entry name" value="FZ_RECK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22961">
        <property type="entry name" value="RECK-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reversion-inducing cysteine-rich with Kazal motifs N-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Reversion-inducing cysteine-rich protein with Kazal CC4" evidence="3">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Reversion-inducing cysteine-rich protein with Kazal CC4" evidence="3">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Reversion-inducing cysteine-rich protein with Kazal frizzled-like" evidence="2">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Reversion-inducing cysteine-rich protein with Kazal frizzled-like" evidence="2">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="70689" checksum="D6698866F79B6AE0" modified="2017-10-25" version="1" fragment="single">VSLLSLAADSYARENATRIFTEFCPPESVEFWDCVNSTLREIERNENWTGRSCCHLARSLTCRSACATAGRQRDLKLSCRWSDEFALSDCLEHREEVEQCCSSVSNSSCRSICKELFHKSAGRRSALKMYKSKGCFHQVPKCLKGLVDDSSKPSEDPKLLADCCEKAPNRGCVESCLNLIHSLGSIEEVLEGLDNSTPSCHPVKPHSPPWSCFLSRSSPSSTGTSKSRRLPLNVAKLSCCSRAKRKTCRSLCLRAFQSDWSAWQQLENQCLSSSPALETELSRCLDDSEDSCEIGCSGLSFCSKFNDKPTTLFSPRGPLXXXXXXXRAHETRLCRDDCMDLMTSCVDWSAVRGHNAATLCAKLSPPKPEQPCISIKPFFELDNEPPRRTDIDEDINMPCRSNPCVQGQLCLVQPEERRGYRCVPGCTLGAMSNQLIPLGSWAQLSVPKHQKQEQQLCQSICQCSRPRCGESVQCPVLGRSSCLGATPPGACCPVCAGAARLFFSRKQLDLIFYQLPDSDSEDKQPVSLEAMLAALSRQLQVAECALRGSLTPEGDIFIVNQPISRRPSDLQLAACVTEIEKLVSRIQGRSPRIVNEVPLSALTRAEIAHIRIVGNAVTAAATTNSATSLATLLIILSLLNLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP72</accession>
    <name>A0A232EP72_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003004">
        <property type="protein sequence ID" value="OXU20141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP72"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="5690" checksum="C12DB435EE8E9E4C" modified="2017-10-25" version="1" fragment="single">ERKVESTRNEKRRASGGQSRAEKSKFYPEISSPIKIREAYKAMTNNSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPH6</accession>
    <name>A0A232EPH6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002947">
        <property type="protein sequence ID" value="OXU20241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPH6"/>
    <dbReference type="STRING" id="543379.A0A232EPH6"/>
    <dbReference type="OrthoDB" id="8197458at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000515">
        <property type="entry name" value="early growth response protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF60">
        <property type="entry name" value="STRIPE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="425" mass="47496" checksum="4E9973F4CC19821B" modified="2017-10-25" version="1">MLKGVIYFPPRRGTLTGANLSLAEATLDNEPSSNTATREHNTDHQNHQHERHENQEVATSTTVSSNFPTVQDNEEKCNVLQGGVILYSSPHSSTSISSAPSTSVNVCNMPTLRYSAVFATACTQASALNSLHNQQVHSQQSQVIQPQSNQDLWGSLPSPTLNLSNQSFLHSSSLQAGSYGSDTIELLQVDSKPPIVTNYHDSPNSVPSNWLISHDEPYESNILSHHVIQHHQQGTILKQEPNSTYSHTISQQSIQQPTSTNNGGVQLAEYNPSTSKGHEILSQVYQQSTIPLRLVPVKPRKYPNRPSKTPVHERPYACPVDGCDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHVRTHTGEKPFCCDQCGRKFARSDEKKRHAKVHLKQRLKREGNHTNARNSQIPIHCAPPSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPR6</accession>
    <name>A0A232EPR6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminomethyltransferase</fullName>
            <ecNumber evidence="11">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_009846</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01002914">
        <property type="protein sequence ID" value="OXU20331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPR6"/>
    <dbReference type="STRING" id="543379.A0A232EPR6"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF16">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="13">
        <location>
            <begin position="326"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU20331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="412" mass="44989" checksum="92123F69D326DE5C" modified="2017-10-25" version="1">MGSPAGITRALRCLHSKLTTNNERPLLRLFSAKAAAAEPRKTCLYDLHVDRNGKIVDFAGWLLPVQYREAIAASHQHTRTHASVFDVGHMLQTHVTGRDSGEFLESLTTADLQSLKQGSAGLTVFTNDQGGILDDLIITKDRDDKFFVVSNAGRRNEDTALMLKRQSEMKAQGKDVNIEFLDPLEQGLIALQGPSAATVLQSLVQIDLTKLKFMMSVETEINQKRVRISRCGYTGEDGFEISIPGTDARTITEIILEKPDVKLAGLGPRDSLRLEAGLCLYGHDITEDTTPVEATLLWLVAKRRRAEANFPGAQRILDQIKNGVTKKRVGLTLGQGPPARENAPILTAAGERVGKVTSGGPSPTLGKPIAMGYVPLELAKAGTNVLVEVRGKMYKAVVTKMPFVKSNYYTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER47</accession>
    <name>A0A232ER47_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002661">
        <property type="protein sequence ID" value="OXU20845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER47"/>
    <dbReference type="STRING" id="543379.A0A232ER47"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000002">
        <property type="entry name" value="Testis-specific Y-encoded-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39114" checksum="12F57567AF049301" modified="2017-10-25" version="1">MSSPSKKVKKLEESSDGDGAADGRDYDVEIQKALEEIDGCQNQIDGLNEKASDEILEVEKKYNKLRKPYFQKRNDIIKRIPNFWVTAVSFQSLLFRVEYSRPVFQAEQFVNNKKIADILEEEEEDALRYLNKLEVEEFEDIKSGYRIKFYFDENPYFENDVLVKEFHLGSSGDPASQSTNIIWKDGADLSKRGKAKADIKGRKRPLGHRSFFDWFTDHGDPSSDEIAELIKDDLWPNPLQYYLAPDMEIENGIEGDCDEVDSEEEEEEDEDGVDEDGDEIGEGEEGDDSVEIMEDAGEEEEDDEDAANENDGVHDEEDFLVEDEGEREEREGEPLDGEEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES40</accession>
    <name>A0A232ES40_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_016482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002492">
        <property type="protein sequence ID" value="OXU21189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES40"/>
    <dbReference type="STRING" id="543379.A0A232ES40"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000008">
        <property type="entry name" value="GRAM domain containing 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="435"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU21189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="791" mass="89150" checksum="7E25EDEDC2CA434C" modified="2017-10-25" version="1">MYSEDPLQERQVTSMNKSVENLLISSHEVISSINSSSLASQSSSNNLANGSYSDSMQDANSGGDNERSSPIPSPNLSPKPSPQFCSRKDHKDHKDHKDHKEHKDNCTLYCFKTSENQHDNNFEASVSCIITSMLQEITSRSSDSAEVSKHSAPDGRKEARGSDRSKKKSWYSNILYPTYKSRSDNFKRIFKDVPDEERLVVDYSCALQREILVHGRLYVSQNYVCFYANIFMWETLVSLRWKDVTSITKEKTALVIPNAILISTATDKFFLTSFGSRDKTFMMLFKVWQNALMGQIGKSEWKRKCKSKKCNVESMSMTEMWQLVHDCYGEELGLTSDDEDYVSRSLTVPEEKLSTRLSLDSFSEGDIKVENPVSSDALAESPLTQSSPLHSVAGTRPEGSNDPTDLSYSSESEAEKEPLVRIGLRSTAVCTGSHDGRPLIKATLPIHIDRLFTLLFTNSKFFLDFHTARKTTDLIQPAWTEDSTTGQKLRTVSLTVSLTQAVGPKSSQVTETQVMLPCSTPGHLYCLDVETTNCGIPYADSFSVFSHYCLTSVSENESTFAVFSEIRYKKNVWGIVKSFIEKNCWSSMEEYFNSLIKALAVECEESGAGAGGLKRKTRRRRRVTATGVTIQTHSPDHTAFNHQSPVVELPHRSTVNATDLRGESSAMITWILLVAVLGLMIINGLLYYKLWSLEEAATYTIMDLHVLKNTPKTEEDWINLLQQQESLHNVEIKKWQRVLSTAAQLLRQTEESLTQLQMSIHPTTTEKMFSVLKPGLKTHNSQNEQRRDQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESP7</accession>
    <name>A0A232ESP7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002412">
        <property type="protein sequence ID" value="OXU21337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESP7"/>
    <dbReference type="OrthoDB" id="10460776at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="185" mass="21696" checksum="6056915349569D86" modified="2017-10-25" version="1">MPNQVKKLTNAGLPEEILSGRQNHNGEPVLEENGQRNPKENVHNHSNAEKDALNQSNAEENEHNQPDVDNEPIPEENYSMNNFTSAKKKIVRPDAWRILQTEKPNVFLREIIMKLWTARKLANRALDLKKVHINIPNRSPVKRIQLNLLRLLISIFNHFLNVKEDIRVRKIKKYYKIYGHKEILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESZ2</accession>
    <name>A0A232ESZ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002357">
        <property type="protein sequence ID" value="OXU21480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESZ2"/>
    <dbReference type="STRING" id="543379.A0A232ESZ2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127322" description="Phosphatidylethanolamine-binding protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46101" checksum="D43577A0F3E43E56" modified="2017-10-25" version="1">MKLLLTSVLLCSFGIVFGSKVASKFKSSEIVPDVLTTAPNDLLSVSFKDKVLRFIGEELTPTQVKDVPSVAWKSEASGFYTICMTDPDAPSRSEPKVREFLHWLVVNVPGEDIAKGDTLAAYVGSGPPKGTGLHRYVLLVYKQPAGKIDVSEEKRIPNNSRDGRPKFSIQKFADKYKLGAPIAGNMYQAEYDDYVPNISKQLDGVCVLSFQLILCARGIVDVADLVERYKKEGLIPDVLDTAPKNFLPVSYNNKEFEFASELTPTEVKDAPTHIGWGLDSSSFYTLIMNDPDAPFRHDPFMRECLHWLVVNIPGDDFSKGETIVEYLGASPPKNSGLHRYTFTVFEQAAGKQDFNETRIAAWLAEGRLGWSLRKFVEKHNLVEEPVSGNMFNCQYDDYVPEVHAKLGVKSGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUQ6</accession>
    <name>A0A232EUQ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_010752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002091">
        <property type="protein sequence ID" value="OXU22099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUQ6"/>
    <dbReference type="STRING" id="543379.A0A232EUQ6"/>
    <dbReference type="OrthoDB" id="193023at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="10">
        <location>
            <begin position="49"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="9">
        <location>
            <begin position="454"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="641" mass="71958" checksum="DECCB7B1E400252C" modified="2017-10-25" version="1">MSHVQYVDELVKEYLLFRGFGQTLRAFDSDLKAEKEKGFRVDKIVDQFMQYIHTYDLIALRELWGHLDTRLFSRLENHFVPGIRKLENAVLKMYLVNAVINNKPDRVQEFFTKMTPELQGHSEWREWFALPFIKNPEENPTFSVHFSRQWQDTMLVSLHNFLATIFQCMPVPTLLMIDEDTNKIRRLQEENERLRQRLGEMVKIDSILDVNAGPTPQQPPLMDDFYIIAQESPVVDNPKTLRNLIRNIGGGSSPILSRKSTSSIKKHSEADANITKRANTKGRITSLSKSEAVAKRSTSCDSRLTRKRDSSVDTGRESKIKDKLDGSYILLSQEEYTEHKTSIIQCKSNASGSYVATGDADGVIKIWTPIPSPKTVATFTSSTANSNKAVTALDWISKNERYFIHGDNNGAIQLHDTRDCKTIWEIQHEGSRIVSLVCNPTDSTFVCSVSDSGEGKLLLYNIKTKKVERTLPLEKNLTALCSSFNHNGQLLVTGLSNGNVLIHDLRRNEIIDNLSCHSSPVIDIELTNDFTNICALSEDGKLCQRSLSQTGKVVWETKINIEKNAVHGKLFTFDQSGTHMLLCTQSGGNIYKMPPSPQAKILELGGHKGTLCCDWSTANQSGTCITGGAEGRARVSTLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVI2</accession>
    <name>A0A232EVI2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002000">
        <property type="protein sequence ID" value="OXU22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVI2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17664" checksum="0823E4F3AF4F0E43" modified="2017-10-25" version="1">MLKQPRFSLVEKRIEKSDGTDPKKVTGASWQKPVTRQTMSYRKKSTSSRPYEWAGRTRIARKEEKIEASTTESTNLSDKQKMGSVLALRREINEWRRQEDLRSKVNQALERSARVTGATDTEDNKDNTKFNDTLKCIVEASTEETNKENYAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVN9</accession>
    <name>A0A232EVN9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_004219</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001972">
        <property type="protein sequence ID" value="OXU22413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVN9"/>
    <dbReference type="STRING" id="543379.A0A232EVN9"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13717">
        <property type="entry name" value="PBP2_iGluR_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000143">
        <property type="entry name" value="Probable glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="351"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU22413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="56187" checksum="06A5869B774C5D17" modified="2017-10-25" version="1">MNATAKPTYRVITIPKPPFVIYDPDSNWYGGFLVDLLNEIARRLNFRYEIEMQEESDYGFMDDQGNWNGLMRDLKEGKADIGLAAVSVMSERMKVVDFTEPIYKPTGISVLMQKPISKTDFYRFLTVLELDVWLCIIGAYLFTSLLLWIFDTWSPYSYRNSKAKHKDDTEKRIFGCKESLWFCLTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTISKFEKTIETFDDLISQYKYAYTCIQNSSTNRYFQRMNDIEYVCYEKWKDMTLNDSLSPYERAQLAVWEYPLSDKFIKIYSAISHYGMVASLQDGLDKFNSTDSRFALITEASDVQYQAMIDCSVKEIGPEFSKKPYAIVLQKNSPLTKEFNRVIYNMKNDNWLEALTDKWWKYNPLRQRCHDKDEMNNGIIFENIGGVFVLIGVGIISAFSTLVYEYFYFKCLRDKFERIFEHKLKAIFRRQKNFARSISVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW54</accession>
    <name>A0A232EW54_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001909">
        <property type="protein sequence ID" value="OXU22590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW54"/>
    <dbReference type="STRING" id="543379.A0A232EW54"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="224" mass="27225" checksum="75CD0CDA40A6760F" modified="2017-10-25" version="1">MHYSIIYAILISAIIPAIRGFILDVYGGMVAWDYMNGGRRFNCAQQKKKHQSDKRIPVVDVSHFLQEIKQSYNDLKSYNDERERQRQVEAERQRRQREQEERERQEQIKQQKIEQERVENQKKQEADRLRLEDEKRLQMIREQLGHEEERKRQQLFVLEQEREHERLKQLDTLERIKLVKPMIASQSGAELCFAKTPDDRLDDDAWRDYIFDWKYDHCIIASYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW79</accession>
    <name>A0A232EW79_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001916">
        <property type="protein sequence ID" value="OXU22576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW79"/>
    <dbReference type="STRING" id="543379.A0A232EW79"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU22576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="664" mass="72614" checksum="FB1132AA990F80AD" modified="2017-10-25" version="1" fragment="single">WSVSDALLRRAAACSKMAVQLDGGGKDDLKTQFVTREGTYKLMTLSEYSRPNRVGYTNSQGSASVRVSFVTLPDPADPTGTQGLGDRMCFNFGKELYVYVYRGVKKAVDLNKPVDKKLYKGTNPTCHNFNQTTATAESAPLLVGFSTGLIQLIDPIKKELSKLYNEERLIDKTKVTCIKWVPGSSNLFLVSHSSGQLYLYNEELMCGTTPPHYQPFKSGDGYAIHTCKTKSTRNPLYRWVIGAEGCCINEFAFSPDGSNLAVVSQDGFLRVFHYDTMELAGSARSYFGGFLCVCWSPDGRYVVVGGEDDLVTIWSFHEKRVVARGQGHHSWVSVVAFDPYTTSYGEHDPDFSGSDDEMSVPHNNHNHVHEKTKRLSTTSQSVHSNRNSCSSELRVSGGTCYRLGSVSQDTQLCLWDITEDVLRQPVCPKQRASISAAGSGVFTSSGTFSSGNGAMSNHHTNNSKLTNSNNISFKENASSNNDSSNNSTSTNVAVSTVNSLTQRLAGGLGFGERRSDNHKRNFSLTIRGSGATSNATVVQNSGTDKTGTSTNGSNLNSVGGSLGTSKKVSSVMDDPMRLIGTAWCPRFDECPVLEPLVCKKLAHERLTELVFREDCFVTACQDGYVYTWARPGHMVGPLTISNTLHRPHNHSHSYPVTSVRPNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWD2</accession>
    <name>A0A232EWD2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001878">
        <property type="protein sequence ID" value="OXU22662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWD2"/>
    <dbReference type="STRING" id="543379.A0A232EWD2"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="92125" checksum="F8226363F6A2E3C3" modified="2017-10-25" version="1">MSPANKSVLRPDEMFLKCLFYVFQFLGTAPITIKALGTKKNKAYHFLFVSSRLGILHNCILVCIFIPTIYLMIEDALARSFLREKTNLELVVDSFCAIYVVVPAIVFLFKISINAEKAIMIINKLNVIYQKRKIEFKKDLLRSVKIIVFMNVVLFTIGCSFSSYCHISNLLPVPSFVTYQMTFIQYTLILKFLHYLYQSTNTELQSVLRSKVPIFIVHNRFLGIDSQRISTKIELLREIHVVLSHLSKEVSDFYALPMFFCISNKFVTLVQYVYYATAILSDKQEITTQYEILILSIWFTIVEAIPLVVLARAAGLVVKESRRTGEIVGGLIADCPNKLILKQLNGFFCHLLLVQVDFNVYNLYQINEPLLTSLTSYITTYIVILLQFKVTNCPSDSADHTENGSTRPSMFLKCLFYAFKLFGIAPMAIKTLASKKNKACHFLFVSSRLGILHNCILLCISISTIYFIIDDTLSRSLFTDKSNLELVLDTACGICAVLTSVVILLKMSFNREKAIIIINKLNIIYQRMVESDKKNPSILLLRSVKIIIFSIFIPTIFAAIALGVENSSILINCISFTTYQMTIIQYTLILKLLHYLYQSTNTELQSVLTSKVPISIVQNRHLGMDTQRVSTKIELLREIHVVLSHLSNEVSDFYALPMFFCISNKFLVLIQYCYYIATVLSDKKDTTGQYEIILHCMSFSTIEALSIVYLTRAAGLVVTESKRTGEIVSELIADCPNKLVLKQLNGFFSYILQVQVDFSVFNLYQINESLLTSITSYITTYMIILLQFKETSCPSGSIEQTENGSTPPSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWI9</accession>
    <name>A0A232EWI9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_009061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001855">
        <property type="protein sequence ID" value="OXU22713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWI9"/>
    <dbReference type="STRING" id="543379.A0A232EWI9"/>
    <dbReference type="OrthoDB" id="7677245at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="3">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU22713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="87516" checksum="89C2BEB48DEAC5CF" modified="2017-10-25" version="1">MAHIGNSTCHADPCIQHSASESTSCILQRLLKMQQVPKTAYLLLLLLWTVAGCDAALSILFNTKNGTVYHVPVNLENRLETPIAVSNTTIPTTHCQDDGSLGQANIVDLDYDESRQRVLWMSWNERLYSSQLPISNATDGNRSDELLFWYDYYDYVQFSRRRIAWDPVGEKLYSVDTFWNPTVEVVDLTGKHRSIILAFGTTGKWKDYVFEGKMPADVEKDAFVAMTAKQELPMDLVLDPGTGVMFIRTNDSWSSRIHRANMDGTSLKLLITDAGKIVDDSCRIDVDRVNKRIYWNDREKGSIESADYDGNRRLTVVKAANPVALAVDGNVLVWSQNTTESIVSDYSRFADPSLRGHLSVCKLTDNTCEPDEIRDTSLSGIDDVPYKLKAVPDQAQQIANPCSTNNGNCQQICLLKPSTDPIKPNPSHGCGCKIGYRLSANSRDCEPILRYLVYESDNYLRARSLEPLERDNETRPYALFPSQVVDNVVARDQLVAIDYDPKADKMLVLGCKTLKQIDLDDNLRGCWRVARNSSDCYKHMAYDWESGKVYTTKVKGMNGEYELGVVDVPSSFRRFGIVVPAILRSIDRPLSLVVHPKTGYLYLLTFSNATNASVVSRMNVGGLDYIVLTIAEALDARGLAVDSLNDRLYWFAESGRVGHSDLGGNDVKVLPVEAPVLRPDSILVDRDWLYVKNETSIWRMNKKTGADVSCLVPEVKVSQHYHAKLKSTMSVVARSPGSFSYGDDYQITKSACKVYCAYQEFAQYNATLDEKFCKCPNSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWT5</accession>
    <name>A0A232EWT5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001823">
        <property type="protein sequence ID" value="OXU22806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWT5"/>
    <dbReference type="STRING" id="543379.A0A232EWT5"/>
    <dbReference type="OrthoDB" id="205745at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF24">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21892">
        <property type="entry name" value="TMEM145_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511530" evidence="7">
        <location>
            <begin position="21"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="8">
        <location>
            <begin position="188"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="464" mass="52951" checksum="508ABA274DBAF2ED" modified="2017-10-25" version="1">MHNVYVILFLITLVDRLCSARIITGQLTTHQNWAFLARFCFLSEKGRFQYDFIIDDEHTEANLLLYYDSPTQWPSVYPSNKTCFERESVLSRELGQIVSLSPYSTYTSVSGCYFTSEDKNQVRCKSYREFRSSRPRWWFIALSDCHNDKGLNISYWISLTNAEEGSFWRYHFSADEFYILPELMIGACIYILLIGFSIYTAFELRTRRLLHITYKLFMLSLATQFCGLLCEIYSNVNRALKGFDLKGVSLIGNLLEACSETTFTTLLLLMSLGYTVTKSLLTPLETWRLSAFIGITISLQLLLFVYEAEAFDPGLVLYLYESPPGYGLLALKISAWVVFVICCYKTSKNAAIKFHFYGSLLSLGSGWFLCQPLTVLTITFLIDKWVRESVVKGSSLWVIFVGHLTFLYVTRPSSANTNFPFHIRTCQVVPIGGEGQGHAYEPQSRTAMTIFTLSHSPPTVNTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWU9</accession>
    <name>A0A232EWU9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_010982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001819">
        <property type="protein sequence ID" value="OXU22822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWU9"/>
    <dbReference type="STRING" id="543379.A0A232EWU9"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="311" mass="34859" checksum="9CD7015D62516D4D" modified="2017-10-25" version="1">MSLHGESPLSDTEGEEIQAIAYETFSEVSASCGSAQQNPINHRDKTNDDDGVTEVQPREKSARSFAKKADFVDKINDDVATTSSTSSNNDICRICHMGNSTSTQSLLGEHGNRDANRNAASRTSSCNLNLGLLVSACRCRGTVGLVHTKCLERWLTESGHTRCELCGYRYATIRVPRHGILRSILIWIKTFVATRQMLLDSLYLVVTTPLAVFSAYVCAMTLKMALENRIGDIPWTIVAMLPTCSLTLVAYWGWLLTLQRLHGRRWRQYWQSNFIVQLVPDSPILANQSSEDLDFQQEDVYEDVPDIFNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXK6</accession>
    <name>A0A232EXK6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001746">
        <property type="protein sequence ID" value="OXU23039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXK6"/>
    <dbReference type="STRING" id="543379.A0A232EXK6"/>
    <dbReference type="OrthoDB" id="7555456at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="19277" checksum="98305113D73484AC" modified="2017-10-25" version="1">MFRVKKGAFMRAKMFRIKKEGLYEGEIGKDRPIAYASRVLQPAELKEAIYEKEALGIMNAIKTFKNYIYGNKFIIVTYRRSLSWLKYANNNERVQRWRLKLADYDYEIVYKAGKQNRNADALLRNPVAKMDICVVTRAQKRREESQTLQDLTNDEKIKIINEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXR2</accession>
    <name>A0A232EXR2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001710">
        <property type="protein sequence ID" value="OXU23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXR2"/>
    <dbReference type="OrthoDB" id="7698093at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="18148" checksum="AE998B487FA344FA" modified="2017-10-25" version="1">MENLTEQGEKAGVPGRKGRPTLAGGYYQKGETKEMKRKKEIRDSTGAKNKNGTRKPRESLTRPDALVIKAAKGNSYAILRKIKAESNLTVIGNCLNKIRKPVSEGLLLNLQCTKEVKTQKLQEAVQAALVKEATIKRFQHKVVFEIKDLDMLTSEQNILEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXV9</accession>
    <name>A0A232EXV9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone deacetylase</fullName>
            <ecNumber evidence="15">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_000096</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01001656">
        <property type="protein sequence ID" value="OXU23306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXV9"/>
    <dbReference type="STRING" id="543379.A0A232EXV9"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10005">
        <property type="entry name" value="HDAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000004">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="20">
        <location>
            <begin position="25"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="380"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU23306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="434" mass="49337" checksum="244CE76C615AE14A" modified="2017-10-25" version="1">MLSSNRKVSYFYNPDVGNFHYGPGHPMKPHRLSVIHSLVLNYGLHKKMQIYRPYRASRHDMCRFHSDEYVEFLQRVTPQNLQGYTKYLSHFNVGDDCPVFDGLFDFCSMYTGASLEGATKLNNKSCDIAINWSGGLHHAKKFEASGFCYINDIVIAILELLKYHARVLYIDIDVHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDASYVQVFKPCISNVMEYFRPTAIVLQCGADSLANDRLGCFSLSTKGHGECVKYVRDLNVPLLTVGGGGYTLRNVARCWTYETSLLVDEPISNELPLTEYIEYFGPDFTLHPEVVTRQDNANSKQYLDTITRHVYDNLKMIASSPSVQMHDVPCDALPPEDERHPEPDPDSRQNPQDMDKIVEPANEYYSGDKDQDKMDTGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY26</accession>
    <name>A0A232EY26_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001657">
        <property type="protein sequence ID" value="OXU23301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY26"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="10297" checksum="FEA2EBCC18E545A5" modified="2017-10-25" version="1">MWVTFSDSTSANAYYYSLANTFEKIRLYYSYQYLFMIGQVTQSIVAWVDGDLTLDENLADNVGLQIAYSIFKNWAKENKKEFRLPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYJ7</accession>
    <name>A0A232EYJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001678">
        <property type="protein sequence ID" value="OXU23248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYJ7"/>
    <dbReference type="STRING" id="543379.A0A232EYJ7"/>
    <dbReference type="OrthoDB" id="423807at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="128"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="561" mass="62669" checksum="8AA2E1F3AD3B97AA" modified="2017-10-25" version="1">MKIFRRSRPCVTSFRDELVSDRTDSRVSVISVISDSNPSSGHTEEEEEDDLSCCHRATCCCPSFRDVLVTEPVNERFCGPFTYANVFWLITVLAMLLMSYASLYFYIGDPLLPGGSIFGLFAVVVFAYFLGWTLAYLPYLNLPPVFGMLLAGIVVRNLDWYDIHESLGIGASSKIRTFSVTFVMLRAGLQLTSSALREHPLFVLNLAVVPCTVEMLTVALCCRCFLDYPWAWAFLSGSIIACISPVVPVNCVLALAERGYGEDKDMATLLFTAASIDDIHIVSVYAICFAFIFTHDDEPMRWWSYVPGSLRDLLMGVTCGAALGLFFVFFPHRRHKYALWYRVCCLVLGSLMCTSGASKIAITGGGFLATIIMSLIATTGWRVLSVPFDVKPLRKAVHVMWHLMQPLLVGVIGADIDFRDWSLARFGLYIICIALGLLMRTAFAYLATLRTPFNVRERIFVALSWLSKGTLQAALAPMSLEQARQNDDPTELALAIDVVRMSVVSIVFLAPLGAIIMMLTGPLLLGRTSDEEHRRRRELSYLRILSLQPLRKRRSTAIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYL0</accession>
    <name>A0A232EYL0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001567">
        <property type="protein sequence ID" value="OXU23576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYL0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9379" checksum="FA679DA567F5641C" modified="2017-10-25" version="1">MRWRPWRDDRVSALQARGSRFKPGVRHFFVALFTGNTTFPALLVVPEPCLTTSTATTECLPCKPEDLGSSLGSVTFSVYSSLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ20</accession>
    <name>A0A232EZ20_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001530">
        <property type="protein sequence ID" value="OXU23672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ20"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7414" checksum="4A73C9CF4F045E2D" modified="2017-10-25" version="1">MLRVDFQSASVIPCCRSARHPTGEEPEVTMPKMQQQQQRGIGSLLRDLWATNPLSHSRREFGGGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ61</accession>
    <name>A0A232EZ61_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001540">
        <property type="protein sequence ID" value="OXU23645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ61"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="10383" checksum="C600079F41057C16" modified="2017-10-25" version="1">MQSSRNYIVFPSAIRKVGCAPYRLNRMRRDPYNDKRVMHYDWKLCQTLIKIFHEHRLSSVEIKKLINTPEKLSDKKSIFKMIWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZY7</accession>
    <name>A0A232EZY7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001436">
        <property type="protein sequence ID" value="OXU23981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZY7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="158" mass="17122" checksum="1019C391F2A7041F" modified="2017-10-25" version="1">MATPPAASSGSGNSAADAAASNTNTTATSSAATNTTGNATAAQQQQQPEPVDPATLDFKSRSIEQAVLPLVSKFWSETCKSVFYMKNYALTELRLTSTDPREISQKSPGRRSGSKKAPLSILNGLREKEAKKAGLYEGKERRRDEELSIYEHYYLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0J7</accession>
    <name>A0A232F0J7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 134</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001398">
        <property type="protein sequence ID" value="OXU24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0J7"/>
    <dbReference type="STRING" id="543379.A0A232F0J7"/>
    <dbReference type="OrthoDB" id="5854099at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026321">
        <property type="entry name" value="CC134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15002">
        <property type="entry name" value="ERK-JNK_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28817" checksum="0C0F5D655B00EECB" modified="2017-10-25" version="1">MIRDNMAVAGKFRPRLAAARLVDVGGVIVVAIALLGVVTAHARDDVEPIAEEETPARENLNSVNRELFKRLFVKRRKEHLEAVRNLRQMDSYERQYKMIDVLAEKMFDFIESKKPLLENLTEADLRSVSFAVDANNDVQDAITSVLENVALFGDVVLNLPDITQRILKIQPRWNATMRWSFDFLNRTKDLLDKSTLEMIELALQELNITDRSPNYFNPNRIGNKPSRSKEPKLATKKEKRKKGPTMTRIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0X5</accession>
    <name>A0A232F0X5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="12">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_001601</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically phosphorylates the activated forms of G protein-coupled receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01001325">
        <property type="protein sequence ID" value="OXU24355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0X5"/>
    <dbReference type="STRING" id="543379.A0A232F0X5"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05605">
        <property type="entry name" value="STKc_GRK4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000009">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000074">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="14">
        <location>
            <begin position="59"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="186"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="452"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU24355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="644" mass="74548" checksum="F5C0C2D34F1539C1" modified="2017-10-25" version="1">MELENIVANTVYLKAREGGGDSNKGKSKKWRKILQFPHISQCIGLKDKLDIRYSYVVDQQPIGRLLFRQYCQDKKPAYHRYNLFLDAIEKYEVEMDENRTEMAKLLFEQYLKREGSEVVDILNDSLITQCEERLGSAGKEIFVEIAQTVKNFLAGEPFAAFLTTFYFYRYLQWKWLEAQPITYKTFRMYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMVLIEKNILQKINSKFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFDINRARFYAAEVVCGLEHLHLQGIVYRDCKPENILLDDHGHVRISDLGLAVEITEGDMVRGRVGTVGYMAPEVIDNERYTFSPDWFSFGCLLYEMIEGQAPFRARKEKVKRDEVDRRVKEDQEKYSHKFTEEAKSLCQQLLKKSPKSRLGCKCGRHGAKEVKLHNFFQCLNWKRVEAGMWEPPFIPDPHAVYAKDVLDIEQFSTVKGVNLDATDDTFYSKFNTGSVSIPWQTEMIETECFKELNVLGPNNTPTPDLLINHPPPNNENRGCFPFRRKRVNNENFRSTEEAERTYPRDSTVRVPFVRTIAKPKLGDASQLIQDEFRQRQCNDQVYRAALRKRWRRLLLSEPPPGLEQDLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F121</accession>
    <name>A0A232F121_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001317">
        <property type="protein sequence ID" value="OXU24384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F121"/>
    <dbReference type="STRING" id="543379.A0A232F121"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="6">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16382" checksum="86566AD5D9293569" modified="2017-10-25" version="1">MSGITDVSNKDLYKILDCTVDSSPEELKQAYHRKILESHPDKSTDPPKSTETFHDVKQAWKILGNPVLKKEYDIKCRQADLEAQGALIYARVSPAELEETEEGDILSYQCRCGNSYLVQKSDLEEKNCVIHVPCQDCTFSIAIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F188</accession>
    <name>A0A232F188_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001272">
        <property type="protein sequence ID" value="OXU24546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F188"/>
    <dbReference type="STRING" id="543379.A0A232F188"/>
    <dbReference type="OrthoDB" id="7681398at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="26772" checksum="B90BF4B86E8E09C3" modified="2017-10-25" version="1">MPYTRFSKLTEMIDFNDNDSMLPRTDPNYGKLHKIRPLIDHINQTSNKSYNTSKTVSVDESMIPFSERSSFIQYMPMKPIKRGFKVWCLSDSSTGYVVKSEVYTGKARDGSKNPLGARVVLNLVSNILGVGYLIAFDNFFTSVNLVEELLDKGIYSVGTVRNNRKGLPEMMKAKEKTKRGDFNNRITKGISAIKYGQETSHNVDVSFQSYGNCRDHSETERWISASYILSNYDPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1J4</accession>
    <name>A0A232F1J4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001306">
        <property type="protein sequence ID" value="OXU24412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1J4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="34" mass="3853" checksum="753133263A856C8C" modified="2017-10-25" version="1">MVYYSPLRATEGDIIPPQKKVSLRRVSTDMSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1T5</accession>
    <name>A0A232F1T5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3456 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001310">
        <property type="protein sequence ID" value="OXU24397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1T5"/>
    <dbReference type="STRING" id="543379.A0A232F1T5"/>
    <dbReference type="OrthoDB" id="6020060at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF8">
        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012036922" description="DUF3456 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="5">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="214" mass="24477" checksum="040E7E62030275C2" modified="2017-10-25" version="1">MLYYCLLFCLLLNAIYCGPEEQEGVKYADKCEVCKVVATELEAKLDETGKTSDVLEIGYSIDDVAPRKRKEYKKSELRLIESLENVCARILEYNIHKERSDSTRFSKGMSQTFKTLHGLVDKGVKVDLGIPYELWDKPSVEITILKTQCEDLIENYESDIEDWYYKHQGDIPLTKYLCSERASKGDDACLKEKGDTGATVTQQTTEKSQQKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2A8</accession>
    <name>A0A232F2A8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein with SprT-like domain at the N terminus</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_007959</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Spartan family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001180">
        <property type="protein sequence ID" value="OXU24835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2A8"/>
    <dbReference type="STRING" id="543379.A0A232F2A8"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="17">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="228"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="433"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="507"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU24835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="682" mass="76119" checksum="D15FF943FD7D6B5C" modified="2017-10-25" version="1" fragment="single">VRMSWITYDEKVARETHEQLNVTGITENAVFPKEKETGNYRPKTLVDETLEYIDPTPNIYTLFVQFNEKFFWNVLLPVQVKWSPRMTSCAGVCSFHPRNRECVISLSTPLLKLRPRKDLIETLLHEMIHAYLFLTNNNRDRDGHGPVFQSHMKRINQEAGTNITIYHSFHEEVRLYQQHWWRCNGPCQKRAPYFGTVRRAMNRAPGPSDFWWKEHQLTCGGQFIKVKEPEKPEKIKKKGDAKGRTSTSTVTKPSENNSLTNWVIKTDSNKDKNIPNKPNQPPKANGNNIKKPNTQPQGTGLSKPVPKPTSTKSNSVSNFQTDLTKLGNSTNNVHGWGTGGPSGSSNKPSHKPQVKGWNNTKSNSTSNVQTDMKKLGNSTNNVHGWGTGGPDGSSSNSSSGNRNSTNNSNSSLSFSGTLGGAGTGRSILLDKFSNTSATNNTQKTSSLNRTNKTQKTNSLNRSNSTTSTNSSFSVETASVLTKTVLCPICIKSVDELKINEHLDTCLDSPQEPEVISDSSHKKRKSEDHYSTSNKKLKDESQQTSSETIDCPMCSKKLLPINFNDHLQKCLSSDMLEEDDDVVSLHDSSSSSINLHDSPHRCLICDKKLEPGMSLNEHLEECVASVFNESNNDDFEEKDSSTGDKSIKTEKEVLERYPCPICMSLIEESLMNDHVDVCLAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2M6</accession>
    <name>A0A232F2M6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_012242</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001139">
        <property type="protein sequence ID" value="OXU25014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2M6"/>
    <dbReference type="STRING" id="543379.A0A232F2M6"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044020">
        <property type="term" value="F:histone H4R3 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000003">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000008">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000029">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1 8 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="14">
        <location>
            <begin position="30"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="13">
        <location>
            <begin position="287"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="15">
        <location>
            <begin position="458"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="410"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="11">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU25014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="628" mass="71841" checksum="8FAAEF67114D51F2" modified="2017-10-25" version="1">MAVSKNVSCGLDFCSVPDLKDCLYLANCSKYHFVCIPLVHPNYKREFISPEIKRSEPWTRSDLILCSSDWSTLVVGKLSPHIYVDSKIHSVAKNSEETLLQELALASHLGLVAITIKLKGNIENNMNLARIIFDKLSTTQNFQAQVWIQVPMENPKKQAYSYREDIDLDKTEIESTWQWWNQFRIVCDYDRKLIVALIVSNDLPDEDEITRWLGEPVKCLIIPTTVFITNKNGFPVLSKAHQAMIRKFCALDVQFVITGANRHQNIIHYYHYMDHLWKTWQPNGPIERFARGYEDYLQCPLQPLMDNLESGTYEVFEKDPIKYAEYQAAIESALKDIGPEKEARNEKDPIVVMVVGAGRGPLVRAALNASANAKRQIKVYAVEKNPNAVLTLQALQQEMWGDVVTIVSSDMRDWNAPEKADILVSELLGSFGDNELSPECLDGVQKFLKDDGISIPCSYTSYIAPVQSSKLYNEVKGCRDKDKHSLAHFEMPYVVHFQNKYDIDLPQPLFTFNHPNKDAKIDNSRYGKNIFKAEQDCVLHGFSGYFLAILYKNIKISIEPRTHSPRMFSWFPIFFPIKDPVNLKAGDEIVSHFWRCCSSKNVWYEWSVEKPVPIPIHNPCGRSSTIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Y2</accession>
    <name>A0A232F2Y2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001178">
        <property type="protein sequence ID" value="OXU24848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2Y2"/>
    <dbReference type="STRING" id="543379.A0A232F2Y2"/>
    <dbReference type="OrthoDB" id="7222477at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF209">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008741" description="Cuticle protein 6" evidence="3">
        <location>
            <begin position="17"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="84263" checksum="B13894899D91515C" modified="2017-10-25" version="1">MTPWLMAFFCLATAGCSNVTDQQTSETQHDHQVAILKQIRKINEDGSYTYGYEAGDGSFKVESRDVLGNIKGTFGFVDANGEIKRVSYSSSNGTGFKSTTVSPLQEQISVVQNIPRNNRTTTTTKKSPSIVFSTSTESATKSSVVQSIPRTRKTTTAPITSTTTTTSKEGPTRSSFVRPKGRHRFVINGQQRPIALEEEEIVDEDSQITRPNSSDKSSSLRRVIFTKRPVDHNLRPITEEFEDKEEEVKITTGNALRRQLQEETTKASTPVVEHEDDHADVYGGALSTSRPLFTTSSPTRSAQRAASLRHERQKHIYVNQDNGPAKFEQTPRTYEQHETKNHVQEDRNTAQQVFIRTTTRAPGDPREYVRQNGEPVYVRQQPDAYLRDLPAGGILVPADENTLEADQRYRQIPLNRLLLSRPEFSRLLQTPQQPLYTGPGTTDANIHYLTDSPPAAQEQEEAAPRVPVNPAYLARQRAAYQRQLAYQEGLSDPRRPLLRPAPVPQPLPQDEREYQNITPEYPYRMGQYALPPEPPNPIAPPLSRRDFQLLLRRLLVSQYGAQALSYPKTYLEDALYDQQPYPSYQPAYQAAPIPRGEVPYAPEPVAPVPPPLPPPPQATYPERVPLRRAPMYTRAINPLYQQNQYEEYPDSPRYSKRVYRQKFYTQEVRDEGEEILPPQIREALLLRMLQLAINAERPVAMPNTLIMTTTAPPVNRYRKSGPIRSVQILGEDVEDEKEMRKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F405</accession>
    <name>A0A232F405_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_007613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001084">
        <property type="protein sequence ID" value="OXU25200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F405"/>
    <dbReference type="STRING" id="543379.A0A232F405"/>
    <dbReference type="OrthoDB" id="10055806at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF26">
        <property type="entry name" value="SIDESTEP III, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011991526" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="32"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="53"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="182"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="264"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="365"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="474"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="810"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="869" mass="96501" checksum="2E3B9C18EC54030F" modified="2017-10-25" version="1">MAAAAVGGGTLLGLLLLLTTTTTMLIGSAEASGNWDRDDDDSVTTIDVRSVLGHTAQLPCNIEPTTKDDKVYMVLWFRETSVKPIYSFDVRGRAFNTALNFSDKNALGPRAYFNTRLQPAALSLEAVQLTDAGIYRCRVDFKKSPTRNFQVNLTVIVPPHQLLIYDSSGAQVKSVVGPYEVGASFNLSCEVRGGEPSPSVSWYANGEELSGAVDRSEPFVVNNKLSVARLTREHHNTTYKCRASNTNLIAPLERSVLLDVYLRPLSVKILAKPSRMEADKEYRIDCETEGSHPRANITWHEGLAPFTNGRVTDARGDDSKMLVQSTLTFSPTPDEHGKILKCRGQNPALKSAFLEDSFTMNVVFPPMVQLELGSTLKAENIKEGDDVYFECKVRANPEHHKITWRHNGDVLMQNYSAGIIMSTQSLVLQRIERKNAGNYTCLASNERGETTSPTVALRVQYAPICKNKEVTIIGASLEESVRVRCEVEADPAEVDFVWEFNYSGENFEVAPAKFDGNNGTLSELVYTPMSERDYGTLTCWGSNPIGKQSAPCVYQIIPAVKPSPLSNCTAKSALNQTTEFLEVECVAGYDGGLRQEFRLEVYEVSSGKLRLNVSSVTSEVPVFRIPISELLPTTLFYLVSYAANAKGRSEVSLLEDVMLGDSEKHTDSSVSMVPLILLLVGCLMALGITIVSVMLMMYRRRGSTSPVHIEPYMKQPIITPPDSRNNSMLDVTHGDHTYFVEYTLKQVTDYALNNQPDIIQSPQDQEKMKREPQLFLPVRPDTLFAPYDIHKQGLQTNRSESILRKIVGADKLQSGPQPHERNHHSQLHTRTRELRVKHATSTGLPENSEQNPRPITASTRMRSGRISHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4V5</accession>
    <name>A0A232F4V5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_015291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000926">
        <property type="protein sequence ID" value="OXU25866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4V5"/>
    <dbReference type="STRING" id="543379.A0A232F4V5"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="418"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="568" mass="65923" checksum="D376C2A58261C798" modified="2017-10-25" version="1">MEAIKKKIAALKMEMDAANEKVEANEVKAKQENTRADMIYDEVRDLEKKLVQMEKDYEICKSNLETSTAELERCEKAYTKAEQDRTSMTKRVQDIETQLSKKEELRLSATLKLARATELNDDARRMCKVLEERSRLDEERMEKLTSELKDARLLAEDADTKSDDIARKLQFVEEELEAAEERVKTSEAKIIEREDELFIVQNIVKSLVVSEEKANARVADMKDQLKELKKRLKEAEKRAIIAERTVKKLLKEVDFKEDELREEKEKYKALCDDLDSTAAGTRYILWSMNAIKKKLQTLKVEKELAMDRAEACEQQAKEAVGREEKLRDKVDELEKKLAQMKGELEVSRQQLGKSIANLENKEKAYLMVQSELAMLNRQMQQCMGNLEKSEERRNVAQTKLAQAIHSVEDAKRVLENRSKLDEERMDVLTKQLKEARLEAEDADSKSEQISRQLALVEDELEAVEERVKCTDAKIAEKEDKLFIVGNILKSLEVSEEKANQRVEEFKAQLKSLKSRLNETEKRAAFAEKSVKSYLAELDLREERLRKEKEKFKYMCDDLDSTFAELTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5V0</accession>
    <name>A0A232F5V0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_015295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000926">
        <property type="protein sequence ID" value="OXU25870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5V0"/>
    <dbReference type="STRING" id="543379.A0A232F5V0"/>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05513">
        <property type="entry name" value="Bromo_brd7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021900">
        <property type="entry name" value="DUF3512"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12024">
        <property type="entry name" value="DUF3512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="221"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="789"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="816" mass="91438" checksum="A6050F0EB3F766D9" modified="2017-10-25" version="1">MYAYYVGALSPTAFVRVHEPRMLLRCIKIFSQCKPSKNFSSYVAAEGFYATPEKPPALKLILKVGGSCGTPEHVGGDSPGQGAMLSQHYQQQLGFNYSVTGGEGEYDRFLGHKKLKKKKKKKDKRHKHHHKDKKRKREESSQESVGDGDESILEVPKKIAPIHQSLPPRPIIPPSNEPRPANPIAASGLSPHREPRTCVLRKIAERTPLQRLLEHLLRSMEKRDPQQFFAWPVTDNIAPGYSQIITNPMDFSTIKQKIDDNNYQNISEFVSDFKLMCDNATTYNHPDTIYYKAAKKLLHVGLKMVTPDKLKQLRAVLVYMQDLTKDELGFELGTEDLVSPDIHITEEQIEKEREQEEQMEEAEELRKETQRKIRLANLGKFEAIPDDLTPEEILKQARGAAKSAAEKLSLKRVGSKMGFLRQKKDGTTSLQIIVPGDGVIPGTNQRPVSLGQLIGKLSHGTGALAGFREDRRNMSKPVKPLYYGAFGSYAPSYDSTFANLTKEESDLVYQTYGDETAVQYAESILDFTKDCDYTLTMVDDLLDILTNGDHRKTKKFLEEKRRLKEEEEKIKHLLEKPIQDVNRNIPPVEKVKVDIDQLKTLSDIGIDINFLQGLEDDLKVAEEREILQNRLDDTSSMLNNLRQTQHDRLSAPPPPHLANIPKASETEASLAEKITENLSSIAKKLPPSAIAPVDGLRKAMGIAPLGGPEPMEVEPITHNPSIVTENTIIQENGTNQEANNMLPMSMSLDLNSVRQGQLPIQMVLGQNQTASILSATETSGVNDLESELREFLESDPTLGHSPLHDDKTLEDILSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F715</accession>
    <name>A0A232F715_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000759">
        <property type="protein sequence ID" value="OXU26646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F715"/>
    <dbReference type="STRING" id="543379.A0A232F715"/>
    <dbReference type="OrthoDB" id="7733275at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="46875" checksum="00D7CC573F63C6C7" modified="2017-10-25" version="1">MDHHHQVAAADSTVRSQDSNNSSDSKESKASKMTDSTRTSSKPESCLESKHSKDGLIETGRRQQHQKPRQQQPQPPQEPKDDSNVLMFTSCGQLLLGVVLVVFGVLVLVHGAALSGSGAGLWAGAGALVAGALGVVATLATSSSGRTTSGFSSAHLASSLVALALSNMAAITALTAVVRDSQRAAPDVTQLTLPDDESIEVEEGWAGLLASIGLLVASVAELFVSGYTCVTLAPKLCGCLRPSDDQADDEDVTVTTTVDGKTLKTRNMVHQWVIAQNHPVACGKNQPIYVVQPLVPMHPMMQPPYGMPTPHGKFAGGFLPAPSAAYGAVPMLPAHMAAAAYPARPPSQIARGKQQQQKKRRHSSEHSDSGGEARQRRSSSQQQQSANKPMASIGEDSQLQQDLARTYTGLDKRISEEFISIAMDPERKSKASSHHGSEIGANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7R9</accession>
    <name>A0A232F7R9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Granulins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000789">
        <property type="protein sequence ID" value="OXU26498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7R9"/>
    <dbReference type="OrthoDB" id="7553093at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257639" description="Granulins domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19301" checksum="D032BEDDFB9E8878" modified="2017-10-25" version="1">MSKLVLFLCIVFLAVGIVVAQSGCKPPGFICSSDSECCEPFACNPWAGRCTKPIAPPTGGTARRYSQQLVVILYILFEKLSKSQASRFQILFSPSIELRDNLIAHLPLPLVHLSASHELSVSLDQLELLIQLDDFFVINRRIGLHTGKAQVVFQNFYLLVLQALSQKLGSLLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8E7</accession>
    <name>A0A232F8E7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000695">
        <property type="protein sequence ID" value="OXU26935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8E7"/>
    <dbReference type="STRING" id="543379.A0A232F8E7"/>
    <dbReference type="OrthoDB" id="7700115at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="16000" checksum="DBAA5AB548E30158" modified="2017-10-25" version="1">MGEKGRKEGHFRDEATTTTSKDGVKFATGATGQKAPLAAGQKVAPGGKSAAKPATKPSAQKGQVKVTPKAACVKTGKNKKKGQRQQYDLIVTINLGTDGQKTIAENDEEGNMGIKEEKGAQYKVFLEGVSSVNKSWLLNVAALSLTGVTVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8I4</accession>
    <name>A0A232F8I4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000726">
        <property type="protein sequence ID" value="OXU26779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8I4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="9647" checksum="DB68C83FD4ECA447" modified="2017-10-25" version="1" fragment="single">QILFSGVFFSKHTASCSASGKKTKAESQVFRKLCASTMRLSAMRGALPLFRELFFPPSRVVDIEMCAEIPSPGARSYLLLRRAYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8V4</accession>
    <name>A0A232F8V4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000703">
        <property type="protein sequence ID" value="OXU26898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8V4"/>
    <dbReference type="STRING" id="543379.A0A232F8V4"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF17">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="467" mass="53595" checksum="B6CB18E69E93E53A" modified="2017-10-25" version="1">MEICPQEPRPRERLPSIIEVKNKIRQGHIYDYTQYYYKSDLPLDDKTTYKMSFWPGPRTVTKAIVPQGSLTVCEGPFTNETTHKMSYLGNWCVKPQEKILPCVRNFFGRGPIQDKTVQKCDFTWKCGSKAKPIKYKGNLCLPRGSLEDNTTYKLSYYESACREPVKSYAPIRRYEKSQAPVDDSTTYRLSFFQNEPLVQEKQPWKQKPQYHQPTTPVDECTTYKLSYWPQDCPERVQPIKQKSNENILNKACCFDDNTTYGLSYYGGADGDRPRPVVPPENQIFDDCPISHDTVNRMSYVGNWCPKPEKPILPCARQLLGRGPIQECTTQKCDFTWKCVTPEAGFRPEANLELSRAPFECCTTNRLSYMPNCSECLLPNKSYAPIRKHEPSDVPMDLDTTMQLSYQPVGEATRVEKPWAEKPAYHKPTTNLDDNTTYNLSYIPPGTLEPCCPEQCSPCSPDDCSSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8V9</accession>
    <name>A0A232F8V9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_015142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000697">
        <property type="protein sequence ID" value="OXU26930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8V9"/>
    <dbReference type="STRING" id="543379.A0A232F8V9"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669413" description="RCK N-terminal domain-containing protein" evidence="11">
        <location>
            <begin position="25"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="12">
        <location>
            <begin position="197"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU26930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="533" mass="58947" checksum="87BBB854DA65AA6F" modified="2017-10-25" version="1">MSRLTAMVLFSLRAVATFRKGVRAVQMVGRANDHHPPPTFTPPELPKMVHVRGEISRDLDDPNAMRNHRNSVGMTTMNSTKQVNKVKPNVNRTASEGLSSPNQPYNQRSQQEESAYAGYHLAYEVKKLMPTNRASGGSNVNNNGGLQIGIADDQAKDFDFEKTEMKYDSTGMFHWSPARNLEDCILDRNQAAMTVLNGHVVVCLFADPDSPLIGLRNLVMPLRASNFHYHELKHVVIVGSVDYIRREWKMLQNLPKISVLNGSPLSRADLRAVNVNLCDMCCILSAKVPSNDDPTLADKEAILASLNIKAMTFDDTIGVLSQGWFTPCCLYAAGLADCILPRENRDTEILLFIPVGSPIVLQRRGSVYGANVPMITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTADSLANRDRCRVGQISLYDGPLAQYGEGGKYGDLFVAALKSYGMLCIGLYRYRYRTFFPWMVFIGLPHIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F929</accession>
    <name>A0A232F929_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_005717</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SLP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000665">
        <property type="protein sequence ID" value="OXU27102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F929"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="13">
        <location>
            <begin position="331"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="496"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="719"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="807"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1193"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1370"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="989"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="823"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="839"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="906"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="962"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1194"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1220"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1404"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1416"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU27102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1431" mass="158115" checksum="2F7B2D61B44DDB6C" modified="2017-10-25" version="1">MKVCVAHVYWMLLFTSVVSSALLFLIVASESIQNSKFIGPDRNQVVAQEENVSFIEDSKHQFESDSQTKPNIKVSSSLKNKIIQESTLQNTQTPLSASFDVSNKNEESKIPEEIEILKESLTQQPNLSQGISDGGQAVVLTLVDTTAGLQSLASGRADFLSKSASGAEAISNVSTAEDSEDDELVRIPQLELEASNGTDLANNETDETEYNEGSADVVVVVRAEQRSTAAIGDQLAEEDRKEAESDEEPEHEEVGVTQEPPQLPKNPTTAPDLNDSAARARLTGSADDSSAVILDSFVTQGPSDPHEEIPSFNEWAQKRLEEAEKKKTHPNVSVQTANGSPGRGVGNMRMRSKNYASPDCGAKIVAANPEARSARSVLVSTRDEYMLNTCTSRVWFVVELCEAIQAKKIELANFELFSSSPKDLSVYVSDRFPTRDWMLAGQFTARDERDVQSFSLQPHLFGKFIKVELHSHYGSEHFCPISLFRAYGTSEFEVLETETDTDSHSDSRRREISAGGDVVAGSDVENEDEDDEDSVFEEEEESTSEPPGNLFGSARDAVLSIVKKAAEVLVKSDDLKSTNNITKIQESIRGDVLEDETLDDCTTPLYNVACRDCNDDRFARVFQLISCKEHYLESLLNTGFVQETLAKSHLCGSSSGFDFLYDKEACTDGSKAVADRNNDASNYYLQAQLLSSLFTPDYIIALCNVLAAREQRLFVNASHQEQQQATSDGIPNKTRVEQQGNQVPLASTTKVERVTSTRGADIVSPTTDSHKTKADAPVIKSKLELPDSPTLSESLITQIKPTKLSTLNEDAKKQSMATNLESSRSHQTEDGNVHKVEGSMTTESSVPVVTKRTTSPSSSSQDHTQVPINSQESSSQRDVPSATKVTHSGSQQKPSEKASVDSSGETEAKSEEESEAKTKAESAEQEAKVTTQGQDQLNFEGFDFKDLEVESLQANGAAKSDASVTQQTASNTGTPQQKESVFLRLSNRIKALERNMSLSSQYLEELSRRYKKQVEEMQRSLERAVTTMNEESRKGEERESKRIEEVTALRGQIDTLTKVLDDLVYERNSWRINFSTLLQHGIFVLVDVVIVILILSYCRRADDDLDYYEDENDEKSIVVRPKRGKNYEIVKQTCIQLTKKTKKRRPSEIASQVSGTYDQLMIEDAMVTSQLSKKDRRKKRRKEIGILRTSSIKDNVKGDGSLHDAKTKLPSRSASASDALYSLNPNNGSNSLINLGSQRQSRPESAPDNSIIYFSEREQSQPTQYDKRVQILAMEQSHEGSTKSDDEAGTNPDGLNVSVSLEDDAFEQLDSSPSSFRNKVKKLSPSAFMRTALGSRSKRISFNGGSNKKLSQSLDESMIKPLERRYDGKMGSLSEFEVSNGAGDEYNNGQASNGHVEESDESRSSSATPTPSWNKKEKKTNGLKKMVRKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9E5</accession>
    <name>A0A232F9E5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000675">
        <property type="protein sequence ID" value="OXU27063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9E5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7345" checksum="E2E5E098891E5BA1" modified="2017-10-25" version="1">MEKGCYFTNVSFDLTTMKIYNKKNIISRKMPGFDANKPKHKVVISGIAGRFPKSENVTSFRRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9K0</accession>
    <name>A0A232F9K0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000665">
        <property type="protein sequence ID" value="OXU27103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9K0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7414" checksum="0B3BE74329FC4FD8" modified="2017-10-25" version="1">MPEGEFCITIKAYAVRTHYYYNHPRVCKIRFLASKLHAKSSFSTIEERCACVKNEYSVALFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9N9</accession>
    <name>A0A232F9N9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016892</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000582">
        <property type="protein sequence ID" value="OXU27556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9N9"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1093" mass="126870" checksum="4CA77CF42B41B8F9" modified="2017-10-25" version="1">MPTGMDSLNATFQSISSSHLMFLQLSLFLPLENKSFSQRLISNLLQLWNHLMVIVYNVSYAGYGIGMALRRDIEIDYICEQIVVETFSARYILLCFKRAQLRRLIESCKRLWGYLEVGEDIVVRRFERKGHFFRHFLILSSLMAVTSYVVTAHFIRLPPLEANGTERKMLPFRFFMDVQEGPPFNAVYALQIINSYYLVFMFASVETVSLYLIMMACGYLRSLQDRLLSLIMEMNEDDLSKNGEAMFNVVMGCAHFHQKIMIFCKDVDRMTRTLFLFACFCPIYNMSITGIKLLESDEDKFKYASLLFVNLFQFFSCQWAPEFLIIESEAIATAAYFASLQPFAPTHREKINRILYFMMMRAQKPIRLTASGFIELSIETFGAPEATETYTFLAISSSHLWFLRLASFLQLKDKSFSHPLSLLLQLWDHVSVVIFNSMWTGFGIRMIIRHEVDVEYICEEVAVNAFCLRYLVVCFKRVQLCRLVEFCERLWDYLEVGEDMVVRQFERKGHFFRQLILINVLAVATLYVITAHFIRLPPLEANGTERRMLPYRFFLEIQEEPAFSIVYVMQIVVVYFVNTIFCEEVDRMTRMLFLFSCFCPIYNLSITGIKLLENDEGKFKFAAILSLNLFQFFACQWAPEFLINESEAVGTAAYFASLQPFASSHRERINRILYFMMMRAQKPIQLTAGGFIPLSIQTFGATESYSFLSISSSHLTFLRMAAFLPLDNRSFHHPYSRLLQLYGHICIFVYNTMWTGYGYRMISRREVEIDYICEQMVVEGVCLRYIVLCAKREQLCALVESCKRLWSYLRSGEDVTVRQFERKAYFFRNFMLINSILVVMLFIGTASFVRLPPLEANGTERKVLPFRFYVDVQEDPMFSAVYALQAVVCTTIPFVIASIETVSLYLIMMACGYLRSLRNRLLSLTENEDDAILAGETSFRLVVGCAHFHQQIMIFCEEVDRMTRTLFLFACFCTIYNMSITGIKLLENDENKFKFGAILVLNLFQFFTCQWAPEFLIIESEAIGKAAYFASLQPMASSHRERINRILYFMMMRAQKPIQLTAGGFIKLSIQTFGAMVKSAFSFFAVLRSFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9Q9</accession>
    <name>A0A232F9Q9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_000611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000573">
        <property type="protein sequence ID" value="OXU27601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9Q9"/>
    <dbReference type="STRING" id="543379.A0A232F9Q9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000135">
        <property type="entry name" value="RNA-binding protein 39 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="286" mass="34521" checksum="FED4C300752B87EB" modified="2017-10-25" version="1" fragment="single">KTKHRSRSRSRSHSKDHREKERRDRDRDKDKEKDKDRDRDKDRDRRRRSRSRERREREKEVERDRERRERDRDRDRDKRRKRSLTPITLSRSRQPFIKGASPLTNRSDELTPEERDARTIFCMQLSQRIRARDLEEFFSSVGKVQDVRLITCNKTRRFKGIAYVEFKDPESVTLALGLSGQKLLGVPIVVQHTQAEKNRMGNSMPNLMPKGSTIKIEKFFIYDNPSIFVIKWRGSATKASLRSRRSRGARETIYFYIGVRIFRDTEKILMLIFREFFWLINAYFMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAC1</accession>
    <name>A0A232FAC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_013847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01000614">
        <property type="protein sequence ID" value="OXU27383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAC1"/>
    <dbReference type="STRING" id="543379.A0A232FAC1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="197"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="403"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU27383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="592" mass="65128" checksum="AEF63598A9FD37A0" modified="2017-10-25" version="1">MKFGKLVNFGLLNDVRNLVSICNVAQKLMAPRMLAGALMTGTYANSSAGGYRNGGSSGGQNRGSAGGQRSFGAGGGGGGSRFGGGGMGGRGGGGGGMRMGQRPQNSNNAGGNLRKPNWDNETLRPFKKDFYTPHPNVSNRHPREVNEFRETHKITLKGDKVPNPIQFFEEGNFPDYVMQGIKKQGYSEPTPIQAQGWPIAMSGKNMVGIAQTGSGKTLAYILPAIVHINSQQPLNRGDGPIALILAPTRELAQQIQTVASDFGSLSYVRNTCIFGGAPKGGQARDLERGVEIVIATPGRLIDFLERGTTNLRRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVLMWSATWPKEVRMLAEEYLVDYTQLNIGSLQLAANHNILQIIDVCQEQEKETKLGTLLQEIGNVNDDGGKTIIFVETKKKVENITRNIRRYGWPAVCMHGDKSQQERDYVLREFRNKKGSILVATDVAARGLDVDDVRYVINFDYPSSSEDYIHRIGRTGRSQSSGTSYAFFTPQNGRQAKDLINVLREANQIINPKLSELASKGGNNFGGRNRWGYSGGRGRENSFSGTHKRFDNRSSGYNNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAM5</accession>
    <name>A0A232FAM5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_001613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000586">
        <property type="protein sequence ID" value="OXU27530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAM5"/>
    <dbReference type="STRING" id="543379.A0A232FAM5"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393961" description="acid phosphatase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="396" mass="45391" checksum="8E11A35411E690D3" modified="2017-10-25" version="1">MRQLHTLLSFLIICSSSVLAFDRDDTLQAVGVTFRHGDRTPMPAPIGLYPNDPNKNLRFGPIGSSGLTNKGKQREYAFGTVLRNRYNGFLDENYKGSDVTALSTENEHTRMSLQLVLAGLYAPKGQQLWSDNLNWQPIPVDNLVAELASFTYSRRCPTWGKLYKELLESEEWKEQYARFEGLIEELSTLTGKKLKNARQVYQLYHTLTAEKAMGLSLPEWTKEYYPQGPIVNVTLFQYLTDNFNTPLKRLNGGLFLRKMLNDLGVNKDGEVEKKAKINLYSGHENNIAALLYTLNVWKNVIPAYSSAVILELHKKESQYFIKVVYYKGIPEEFEDQTIPGCSEYCPLEDFLRIEKDVLPEDIMDACFGTPEDSQLVPKSSNPIVWIYEKIRSWFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAQ9</accession>
    <name>A0A232FAQ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 29</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein intersex</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_011525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000580">
        <property type="protein sequence ID" value="OXU27570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAQ9"/>
    <dbReference type="SMR" id="A0A232FAQ9"/>
    <dbReference type="STRING" id="543379.A0A232FAQ9"/>
    <dbReference type="OrthoDB" id="6366949at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021018">
        <property type="entry name" value="Mediator_Med29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11568">
        <property type="entry name" value="Med29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="20657" checksum="F7D74F501828CF75" modified="2017-10-25" version="1">MNNMNMPMQQGGPMMNQMVQGNPVQMANAQHAMHPNQTPIQQAQPMEKQDNISKVKSLIGPLRDSLSVALKTAAHTLHQNSLVDTSKGIDPPDHRFNKNMEEFYSICDQIELHLRTSIECLSQNSSSVRYMPVSVMPIRPDNLSSQEALNYSQYLMTVRTQVQYIRDVYETLNHAARAISATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAR6</accession>
    <name>A0A232FAR6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000553">
        <property type="protein sequence ID" value="OXU27712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAR6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7136" checksum="08CB71ADE6D64C79" modified="2017-10-25" version="1">MPYGIIHGGHDSGNTSICLAATAIPEPEYQFDTATYNSPVIYEMLYDTYDCLCHVVEAYSLGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBC8</accession>
    <name>A0A232FBC8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000509">
        <property type="protein sequence ID" value="OXU27932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBC8"/>
    <dbReference type="STRING" id="543379.A0A232FBC8"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11872">
        <property type="entry name" value="SH3_DOCK_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF12">
        <property type="entry name" value="SPONGE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="193" mass="22537" checksum="011D969672F6BD99" modified="2017-10-25" version="1">MKFALLRSQVLFEITELLANEREECNYTKEKSSQGKLPLFHATLSSVFVAAVYNWRGDTRYGLPLEIGETLQILEECAGWYRGFSIKNRAVKGIFPSSYVHLKSCKIENEGLFESVIPLEDPVVREVTLVLREWGGIWKRLYVDRETYKFNTLRKVMCELLEWRRQLLAGTLTTDQTRELKLQIINKVDWGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBT0</accession>
    <name>A0A232FBT0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000518">
        <property type="protein sequence ID" value="OXU27899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBT0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7437" checksum="4138746B59986A3A" modified="2017-10-25" version="1">MLGTKTPSRLSLHVNIPHWNEDEPNREQRRRAKAESRRGRRNQERANANAGERPNAITHINEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC63</accession>
    <name>A0A232FC63_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000483">
        <property type="protein sequence ID" value="OXU28063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC63"/>
    <dbReference type="STRING" id="543379.A0A232FC63"/>
    <dbReference type="OrthoDB" id="7544260at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011811000" description="Metalloendopeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="8">
        <location>
            <begin position="59"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="275" mass="33256" checksum="87FBB59D1C7457B0" modified="2017-10-25" version="1">MLLWILPLLWMTFVEIVCRRVYLIRKDDSLTDYELRAIKKKVLSKYKMRDDVLYGNDLRFGRDRELVWFYGVVPFLFARDYRSEQTLREMMEMFNNKTCIRFRDYEEKRDREYLLIENNGTEFCYTKPGRPTARENHVSIANFPDLCVFDPPMAMHELMHVLGFPDEQQYPGRDTWVTIYWDNLKPEAKRHYLQLNRPNVTDYATPYDYHSVMHLSDERYSLNVEQPTIKAKIFGVLVGSPYNNLSFQDVDKINTLYDWECTIREYKEWYWGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCR2</accession>
    <name>A0A232FCR2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA excision repair protein ERCC-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_010961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000456">
        <property type="protein sequence ID" value="OXU28270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCR2"/>
    <dbReference type="STRING" id="543379.A0A232FCR2"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="10">
        <location>
            <begin position="61"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="261" mass="29345" checksum="73441421FDFE42C3" modified="2017-10-25" version="1">MSSDTEISKDAPQEKKAKVDDANSFGAAFSNLKKSEFFKDELPESTKGESSKNKNTNLNPLLINPKQRGNPLLKHITSVPYEYSEIIPDYVVGKTSCILFLSLRYHQLNPDYIHERLKTLGSSYNLRVLLVQVDVAEPHHSLKHLTRICILADLTLMLAWSAEEAGKIIETYKAYENKPPDMIMERSDTAPHQKLINALTTVRSVNKTDAMTLLSTFGTFKDIIETPSASLALCPGFGPQKAQRLHKTLHETFLRQTNSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD28</accession>
    <name>A0A232FD28_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000413">
        <property type="protein sequence ID" value="OXU28585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD28"/>
    <dbReference type="STRING" id="543379.A0A232FD28"/>
    <dbReference type="OrthoDB" id="10017443at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018795">
        <property type="entry name" value="K2013-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31386:SF2">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2510039O18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31386">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN KIAA2013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10222">
        <property type="entry name" value="DUF2152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU28585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="608" mass="69904" checksum="972F976027E99D0E" modified="2017-10-25" version="1">MRGGGGMFDVHEFGKRVRRSLDGNYSYRKILVLLVIFGGFLLYVGPSLFQWLFSSRREPIEAYEEHCISERLAGFYFDSAEYNANVLFNPPKEDEHTYLPYVGNGLFGIPIQSESWLYIKHGRTLSLPVKWQPLISYQVPEYISYKEATVTHYTKGIVYKYQCFRDGYHIGYQYYAHRELEGIFVQEIKISNPLSNLQELPFKTQASVHWTDSLTESINILVERTSHEFTLVSGYINVPSSSKVVAVSIVYQAASKNIEVKARGSMKMEYLASIKYSEPIAMDQYRQERDSVREKAIDQMRKALVKQQSLGLKQEHVNTWQKYWHSGFRISDSKAKEAINGYKINSTIYYVLSQVPKALPDVEKNVINNEGCYRGHHTLDAPRLWRDTSTIDAINELVRAWSITLEKQGCHRLMTGNPSAVLQAMVLSLGGLRFSNQHLEFNIDPQHLHRDFLFRRISYGNVTHLNISVHVNEDNRAVLGVALDRSDSVYYGCDAGCLDAPVPLSQSYTNFPVKLTTPLTAILYITSDYQHMQDLQNALHVHAVDEAPAHDHHLMALHKHGHQLGGLPTFFWVSICFLIIVFHLFLCKLIVSEYWDQKDRVKVRYNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD79</accession>
    <name>A0A232FD79_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RuvB-like helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016743</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="NNAY01000430">
        <property type="protein sequence ID" value="OXU28453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD79"/>
    <dbReference type="SMR" id="A0A232FD79"/>
    <dbReference type="STRING" id="543379.A0A232FD79"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="67"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="462" mass="51492" checksum="CE51E98235B39E7A" modified="2017-10-25" version="1">MAIAASKVHEVREITRIERIGAHSHIRGLGLDDSLEPRNVSQGMVGQFQARRATGIILEMIKEGKIAGRSVLLAGQPGTGKTAVALGLAQSLGADTPFTLMAGSEIYSLEMSKTEALTQAIRKSIGIRIKEESEIIEGEVVEIQVDRPVSGVGAKVGKLTLKTTEMETIYDLGNKMIECLMKEKVQAGDVITIDKATGKISKLGRSFTRARDYDATGPQTRFIQCPEGELQKRKEVVHTVTLHEIDVINSRTHGFLALFSGDTGEIKSEVREQINQKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRALENEMAPVVIMATNRGITRIRGTNYKSPHGIPIDLLDRMIIVPTIPYQESELKEILKIRCEEEDCEMSNDALLVLTRIALETSLRYAIQLITTSSLISRKSKNIEVGVDDVKRAYTLFMDENRSSQFLKEYQEDFMFYEAEEPAEMEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE21</accession>
    <name>A0A232FE21_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein okra</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_012955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000390">
        <property type="protein sequence ID" value="OXU28718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE21"/>
    <dbReference type="STRING" id="543379.A0A232FE21"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000042">
        <property type="entry name" value="SNF2 family helicase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="334"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="668"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="832"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="882"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="970"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1116"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="972"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1155"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU28718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1167" mass="133045" checksum="3FBC4939AF836BAA" modified="2017-10-25" version="1">MEVENQSGEDGDEISEVISMQSESSILQKATEDLKKLVENNATSKNLPKKNESKENPEQLPESSILRARLQDQVRTGELTPFQAAKKEKDNKNVLGRTLKESTQLLDLEKYLFRQAELAKQQKLLKKKKISQNEKEKSNIPTKKMKIVESNVAERKKNKSINSKNQHSKKSETITSKTQQCSTPMDLDPPSAKDCVVKEHENNLDSNIHDLESSTETSNTLIHEQVSKVRKSFNLDENEENESGSEYVPSDEYDSEEETDKKSERRKKSIMSKQSSRVKRVLDDGDEDIYRQRVEQSDYKKNEPLHKVDNLFKVPLRIWKHLYKYQKVAVKWMWELHSRNLGGLLGDEMGLGKTVQVIAFLAGLDCSDLLSDGGRFRGLGPSLIVCPATLLEQWVKHFHDWWPTLRAVILHQSGTFQGDIDELLHTLKDGGILVTSYTGVLIHKEPLLKFKWHYVILDEGHKIRNPDAKVSKVVKAFLTPHRILLTGSPMQNSLKELWSLFDFILPGKLGTLPAFMEHCAGPITRGGYANASQLQEATALQVATMLKDAITPYMLRRTKFDVQHHVSLPDKNEQVLFCSLTEEQRQLYKQYLRSDDISFVIHERREGGRYRARLLVALTALRKICNHPDLFLYTDNNQEESDEDAALEVDENEIEKFGHWKRAGKMTVVRSLLKIWKKQGHRVLLFTQSRQMMHILEGLLQKENYNYLRMDGTTPMGQRQLTVTKFNQDPSYFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPATDAQARERAWRIGQEKSVTVYRLITAGTIEEKMYHRQVFKILLSNKVLEDPRQRRLFRTSDLTELFNLNEPISGGSSESDQLFRDSKLSPNQSNFSSSKIEAMKKLAAALSKKIGEKANNKTDTAKDKIKEQNSNATTSKDEQKISDSSLNSSSVGENKDVSVDSVHNITDTKEFDNTVHEDDANEIEDKKNESCNLKTIDQESLVTEDDKVDHKSSTIKKKELKQIGPKMNSTEEDVEEGEIVETPGKSTSELNKKSSGNTKKVKASKHQKAHRKHKRHRKNKEKVEDSVSAMFEGERVSCLIGRRLGKSKEPDPIATADDQYVLSKLFSKAAVSSAFQHESVLSNAVLNPEEETPLQRAAKSTASEKMDCIRQSRKWCWKPSWDKPPEEQYDDNDGDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE78</accession>
    <name>A0A232FE78_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000341">
        <property type="protein sequence ID" value="OXU29071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE78"/>
    <dbReference type="STRING" id="543379.A0A232FE78"/>
    <dbReference type="OrthoDB" id="6426610at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="188" mass="20087" checksum="61A17C9C50CB916A" modified="2017-10-25" version="1" fragment="single">MSQPPSRGGPYGGWTPTGRPAAPSPFRPASPYSPTPYQQPPPQQRGPPMGHHTPGLGMVHPMSPVPMMPMSPGISPVFGHPPASFIQCPRPRWPSPISPGNATARPFVPAPQSPLSFSCQSPQPCGPPEYLIAPYRPGEYEFVGVPLDPSSADDEDSGPSTAEIIASQSQDYVDEKLAEYQATIHQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEP1</accession>
    <name>A0A232FEP1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000380">
        <property type="protein sequence ID" value="OXU28777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEP1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012534022" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="9994" checksum="4D1F56896C87F35B" modified="2017-10-25" version="1">MFPRCFIYFGMIALFVAVASIGAEETDDTEVQDRANPAVKAVAKILGSVFASAAAGCLTEAATACKSHWKNPKKALKCGKDWLARNKGRCAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF22</accession>
    <name>A0A232FF22_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000332">
        <property type="protein sequence ID" value="OXU29153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF22"/>
    <dbReference type="STRING" id="543379.A0A232FF22"/>
    <dbReference type="OrthoDB" id="10056847at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19862">
        <property type="entry name" value="DSRM_PRKRA-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19863">
        <property type="entry name" value="DSRM_PRKRA-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19864">
        <property type="entry name" value="DSRM_PRKRA-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF3">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="102"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="209"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="832" mass="92837" checksum="1505661E26B70B21" modified="2017-10-25" version="1">MRQDETYVTDAKVLTLIEHFLVYQVMEDLRQQVGSNMMDGGIDELRQGVGNMMVGGVVPVPNHANNVHRRSKTRVTMHALMSEALPLDEAARLEMKALPNKTPVSVLQELLSRRGTTPKYELVQIEGAIHEPTFRYRVTVADVVDQSVSAMGTGRSKKEAKHAAAKAVLDKLIGVNTENAEVPITNSIHDSQNIQEIPSGYGEEKVVNNPIGSLQEMCMSRHWPPPKYSMEGEEGLPHERQFTIVCSILKYRQVGQGKSKKLAKRQAAHKMWQSLQDTNSNRTQGVDEDEIVQRNANVNARYADLKDSKIATLTTPHSHKVSQFHKNLKSSTGVKLFELQNTSLNDGDVNLVQFLQEIASEQQFEVTYVDIEEKSISGKCQCLVQLSTLPVAVCYGTGMSSKDAQAAAAQNALEYLKIMTKNDDEIPNLKISKIDRKLETETSKGNRISKASVRTLNTDLKTSDNCNVISSEKNIGKKISNSTGENNKIIDRAKSSVERFDTVRSTNCSINTPSGIQLTNSKDYCAKKYVNELGSKFKNYQSECHKDISINQQGSKARSIDNLTTRYSNHVTPSGFHRENNQVTSTQCSRDDNNSSSIYTVGRKTLDHQSNQAKITPVNFPPLRAPQSIVNVRHPFLTEARTKHNEIIPSNGLKSKSTLNTILQSSAKDLESGRQAYHNFGTSTLNMTTNMSPYPRTDPFPQPTLSSLLFPDTGQFSQSASSYSTNQFQTYDPASYHTSTPVIPQFSENSLSFPQYDSTTFVQPSHYPAADITSSQFQYQTPGVGQIQESTMFIQGLQNSITMTDHYTAPNYARAVRTELMHRLRRPPRFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF71</accession>
    <name>A0A232FF71_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000302">
        <property type="protein sequence ID" value="OXU29352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF71"/>
    <dbReference type="STRING" id="543379.A0A232FF71"/>
    <dbReference type="OrthoDB" id="7701268at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353292" evidence="3">
        <location>
            <begin position="16"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="491" mass="54779" checksum="5CC45F6D049DDBAB" modified="2017-10-25" version="1">MLQILFLLSPTVICAQRYRKSTNPNDEPFLPIHPEYPYNPKLMKRGLEQQQAQQVQQTQGLAQISPELYAPKVDARDSYSASFSQAPLYPSYDPYAKASTTPNALTNSPYYQSSYPTYGTNPYNLLNSYGAPFGSPSSSYTPGTPIVPSTTAPGYGAAPYGASSAYPYYYYPSQSPYYYPNYYGQPPYPPPPPPSYTGGPSKHQSEEDDEEEDDRRREKSKKSNNNKNKLRNSDRDNVDNHYVDGANYIISSAKDLDTESSSHRTPSHYNQIEQDSDVQPRAVNIPKTYRLVSVSGQQGSDYNSGSSGYIKIQHLEQLMRQALARLLAQNAAQQANLAQIQQEVNQHQSAKDNHQYLTVPNTIAKTGLSYVVNPTILNRVTPGQYNPSQLLSTLSNNKQSYPQKSATSITLHHSPGIYIPPGKNSNDQSSPPEYSDYDTSETATTRNQQNTGNYPATAEPTRNNYSYSTYRPTQQTNLDDVNFGSKQKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG09</accession>
    <name>A0A232FG09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-Casp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000298">
        <property type="protein sequence ID" value="OXU29369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG09"/>
    <dbReference type="STRING" id="543379.A0A232FG09"/>
    <dbReference type="OrthoDB" id="5600060at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048660">
        <property type="entry name" value="IntS9-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21382">
        <property type="entry name" value="IntS9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="7">
        <location>
            <begin position="305"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="662" mass="74562" checksum="07DA66BCB39FCAC4" modified="2017-10-25" version="1">MKLYCLSSEPTKPCLVLTFKGITLMLDCGLNMQSVMNFMPMPMVPSARFNSLPNWVPRDNYQDWQIEGELKECCGRVFVDSTPEFCPPLEKIIDFSEIDAILISNYTCMLALPFITEGTGFKGAIYATEPTLQIGRFFMEELVEYIEQAPRDTMARHWKEMLHVLPPPLSDCLKPKSWKHIYSMAAVNSALANIQLVGYDQKLDIFGALAVTPISSGYCLGSSNWLISSDHEKIAYVSGSSTLTTHPRPMEQTTLKHANLLILTGLAQMPAANPDTMLGELCMTVAMTLRSGGCVLIPCYPSGVVYDLFECLSSHLDKSGFAQVPLFFISPVAETSLAYSNILAEWLSTNKQNKVYLPEEPFPHAFLVKNARLKYFTSTYAEGFSTDYRQPCVVFCGHPSLRFGDAVHFIQMWGNSPQHTIIFTEPDFPYIEALAPFQPLAMKAVHCPIDTSLNFTQANKLIRDLKPDNLVIPERYMQPPMTAPHRADLVIEPVGEKPLITFKRGEVIKLPLKRRRGRIFIEPELADNIIPSEIRPGLSLASVSGELEVKDNVYTIKNIPSRSNGDRKRKGSSSNPVPVKEELMKERKHEYGNLDPQELLQKLIQEGITGAKLQHTPTSISIHLDEDTYIQISDNSTHIFCKADQKLRRKLRNIIMQCLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGH1</accession>
    <name>A0A232FGH1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_010372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000230">
        <property type="protein sequence ID" value="OXU29844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGH1"/>
    <dbReference type="STRING" id="543379.A0A232FGH1"/>
    <dbReference type="OrthoDB" id="5789657at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012579202" description="LRRCT domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="5">
        <location>
            <begin position="881"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120607" checksum="1536622D5109639D" modified="2017-10-25" version="1">MLLLTLLLGCFLSALGGYIPPGPRYNCPKEIAYIHPCICTRGSDQGLYIECENTNLATLSLAFLNLGNEGIPIEELTIYKCNIARFYGPALYPLNVRILKFIDTPLKFIEEHSFLGVNRTLQELHVVGGSLEKFPKEAVQILGNLTTLHIRGHKIDELPSNIFVESLAASKIERLEISNGTLNSLAIETLAPLRKLKWLDLHGNQIKDLKKSQFKGLRDVELLDLSHNLIDKIDSSHLGDLTKMGWCNLSHNAIADLKRGVFARNSLLKVLNLNSNKIRKLDSNTFRGMRLMRRLYLRDNRINDVGRGTFGTMTRIGTIDLGKNMIKKVDYQMFYQLQYADTIDVSENQVTLVEKLAFKDLYSATVNLSHNAITKIESGAFENCANIVVLDLSHNKIENISKTAFDPATYATTLQLSFNYLTALNQVPLQNMTGLKVLNVSHNNIRIIPRQTFPKLYELHTIDLSYNNLSDIYNAIFQTLFSLRALNLSHNALDKIKPSTFGPLPTLLDLDLSYNKLNDISRGSLTRLASCRTLSVKHNELTKMFLIPISLGHLDISDNLLEEIPSTDVWPSMNALLSLDLSNNRLSDNLGTGSFESLLTLRTLNLQNNGITKPPWEALSSLTSLQYVYMQNNNITTLNKAAFGRLPIVFELNLANNQISNVTERAFEGLLQLLTLNLTNNQITHIPNGAFRGLVSLRNLDLSHNELERLDNKTNGLLDDCLSLEKVNLSHNKISTIERKTLPHDPWIPYKIKEVDLSYNSIAVINFDFTLGTKKVIFMNLSHNNIVDIRRYVLGNMTALQTLDLSYNELNDLSEQDVFQPSNNLTNLILHHNRFNHLPWDKIVSMPNLKHLDLEYNDFSSIDDNLMKVLHNGTRVTYTGNPLHCDCYVRPLRRWLDTFTEIPEDWRSVECTSPSYVADMHLPEVSEVLMSCSDKEILEDPKYDISPDVNDSEKNIWKVTWYVPTREDTGDFYLVVREPGGRKNVLEKDIVYKERSFKIRDLPDPNAKYELCILARDSVGNVKHFRSSQCRILDKHAFSSSSRQSTINILLVLAPIVFTAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGT5</accession>
    <name>A0A232FGT5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000262">
        <property type="protein sequence ID" value="OXU29649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGT5"/>
    <dbReference type="STRING" id="543379.A0A232FGT5"/>
    <dbReference type="OrthoDB" id="5975550at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001336">
        <property type="entry name" value="Epithelium specific ets factor 3, ese3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF190">
        <property type="entry name" value="ETS-DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="249"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="346" mass="39818" checksum="4E9761F27030DD32" modified="2017-10-25" version="1">MRELPQEDSMNPFADYEKTDISNVVSMSQDYFRTFEDQEDHLLLDMDSLVPRNNDDEMLMSRIYSDNASSKKCSLGEETEAEVDGANWSSKPIEDWCQDETINWLMTAASCLGQNYGSIQQNLALPGKELLSLSRHDFVARDPVFGDRLYNLLHTQAVSSQCKSDYFAPRHCAATNMGSHGEQDFANRNRQSDSYQNLCNSSSGEDENRALGSNNVSDAESDNSIEISTKRPPGRPRLLKTKKNPTSQGKLWEFIRDLLRDRKTCPSLICWEDYSQAKFRFVRSDEVAKLWGSRKGNTKMTYEKLSRAMRYYYKRKIFLPVLGRRLVYQFGPNATGWQTDNPNFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGY8</accession>
    <name>A0A232FGY8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000269">
        <property type="protein sequence ID" value="OXU29597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGY8"/>
    <dbReference type="OrthoDB" id="8195605at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10540" checksum="6F767E5127344100" modified="2017-10-25" version="1">MEGSVVLQSTLRRKVSILNKNPSADKDNVLKVALTCTFTEEEEDAFSREITKMENRLIPLTSIDMRKVAFQCAEKLQIPHYFNKDTELAGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGZ3</accession>
    <name>A0A232FGZ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_017032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01000206">
        <property type="protein sequence ID" value="OXU30036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGZ3"/>
    <dbReference type="STRING" id="543379.A0A232FGZ3"/>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="65"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="372"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="848" mass="96616" checksum="BADFD393707984DA" modified="2017-10-25" version="1">MFWLRHNYSHNVEKKSLGNHLHLAVFLCILSRRFVEQVSVFERDVGRGYFTRTFVYVPTDNESIVIEDLKIVKASADSLTVSWSANHENLTSYLIQWFKDDEFVGNASKIFSFQDKIEFTIESLEACSIYNITVTPQTIFDIDNDATKSVIGKTALTQPDAPLIQSASPGKINDALMLNVSWKVPKVGRYCIKHYLVRAEAEIYNLKHFVTQNTPNTSIVLPDLYACTSYKVIVKAIDRNDGKGLESSLQAKPTLDKVTIAPKLVNSINVPPFISTRTTITLNWNVLDQKNNCSIDSVWTDCNYSYTEGYGFEVKERGTTNVTTHGQNPRIVRLLVQDLSPFTKYICWGWTINSAGWSRFGMPVPVFTKQDVPSAPENFRHLENTQFTFAWDAPKSMPGQQQKYKLTTSWKPLYPVPDFCNVTRSAVMENIRPTANNYTWKGGEGYSEYTAYMEASTDAGWGSKSESITFLSDQKGVPDKVTNLDCQTRLRKNDSNALETILSWNLPCSLKGRLKQFELSVFGSRPHSENHVIDSVIFIHDINSLRKNKKFSYSFGELRPEYSYIFSVSATIHGTDEKGEVAKLNTEYPAGIPPQPTKTYIKSITLNPNKIQRTSTSFEILLPLFSQENGNVQYYAILVSQLGFNKEQRSMRFDSKNGDWPDVASWRESMERDFKLPYQASEPRWSPYPNHILDYGSIRAVKIVIGDDITCKDVSMTTKGRLYCNGPLKPDTWYEVRMRAFTYGGYADSTPFKVKTGTLLDKDVLKLFLIDAEMSVGMIIGIVIGILLIGIIVALLLAWKSHAKRKEKKSTEEEENDQDRNRNRRLTMNTHSHSYENSAARTRRRYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHE6</accession>
    <name>A0A232FHE6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxylate reductase/hydroxypyruvate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000187">
        <property type="protein sequence ID" value="OXU30171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHE6"/>
    <dbReference type="STRING" id="543379.A0A232FHE6"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:hydroxypyruvate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF119">
        <property type="entry name" value="FI03731P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="57"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="155"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="355" mass="39372" checksum="A3774B9BE7712A29" modified="2017-10-25" version="1">MHTRLREKSPALLYKRMKLCVSHYLRFRTQWFCTSVAGRAANINMSGKPRVLVAHNDTPQVAVDLLKTKCDVTILKPNWPTEAEVLKVLPEYDALLGKLHIDTDFLNAAGSKLKIISTPSAGYDHMNIQEIKKRGIKVGHAPKVLSGAVAETAVFLLLGAARRAHEGRLLLEQGKVENGFQWLLGHDLRNKTVGIVGLGNIGEEIVKRLKPFEIKKFFYTGDDLGAEFVNLDTLLKESDFVISCVPLTPETDKMFNDDAFKKMRKTSVFVNIGRGKTVDTDALVRALKNQTIFAAGLDVTEPEPLPVGHELLKLPNAVIIPHMGSQTVETRNDMALAAAQNILNVFEGKPLLYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHN8</accession>
    <name>A0A232FHN8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Syntrophin C-terminal PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000204">
        <property type="protein sequence ID" value="OXU30040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHN8"/>
    <dbReference type="STRING" id="543379.A0A232FHN8"/>
    <dbReference type="OrthoDB" id="409749at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF12">
        <property type="entry name" value="IP02644P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Syntrophin C-terminal PH" evidence="3">
        <location>
            <begin position="134"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="230" mass="24856" checksum="72B50C1A72B0DD10" modified="2017-10-25" version="1">MHDEVYSRVKTAAAAVVAGHVYQTRCAGGWRSVFGAVSGRELRLYECAPWSPEAWASPSITCPLIATRLVSSPSKQNEASCSSSNNHQYGATFAVRVGTIDGVITHNLRAETRRDLAAWARAIVQGCHSAAHSLREYTVRCVWQGRACQLVVHHEEGFALYAAGTRGVTGNGISPGSPPTPLWRRPFEKLRMSADDGARLLWLDFGGDDAEINSDLGVDCDLGTGSILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHV1</accession>
    <name>A0A232FHV1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000172">
        <property type="protein sequence ID" value="OXU30321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHV1"/>
    <dbReference type="STRING" id="543379.A0A232FHV1"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000962">
        <property type="entry name" value="RBMX2 ortholog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="156" mass="17637" checksum="EBC8920719DA09D9" modified="2017-10-25" version="1">MNPMTNVKNIAKLGLQELGSDRKGSWHDDYKDSAWIFIGGLPYDLTEGDVIAVFSQYGEIVNINLVRDKDTGKQKGYGFLCYEDQRSTILAVDNLNGIKVCELFNVQSHMTSRTIRVDHVKDYKPPKVGSKNVDEETKRLRLEGCAPKNINMLIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJC0</accession>
    <name>A0A232FJC0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000136">
        <property type="protein sequence ID" value="OXU30640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJC0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="464" mass="52598" checksum="1723114B821974F1" modified="2017-10-25" version="1">MIEAPEKHPEVRMYFIKKVQTFSSMLSIWMTNSIANSGDGTPAIFSVVFVITGLRKKCRMKLLIPIFFHGLRGPRSSVILIRGFEGFSEVLKCVKEIRNGRASSFTIWESVIGDFELVASEEQHRQSPRASSPRDSSCGFIQLVVVRRKSISPSAERKFLIKVLRSSEVREGNEEWKSVIVYDLEIRDSRVSRCATTKPSNTCYGKIIRESTVIKKDDRNTGEASGSLNVLHQKSDRDNKETHLFLYNEECEPKHRIINLPGVVDSVDPRIDAGHGLGEHSRQHAGERRYQFAEKRSCVGVSKLPILPISEGSDHRHDGIWRPGAHEQEEDRKGHLGDPHLDTSLLVLGRERFDVHLLRLGRTPKSQNQALSYYGQKSKPYLLAEHLLVSSDGLDQLRVEVDDQYHRKAVGPGENRGDEYFSVLVVAEEVEAAGRQKSLCNSRAKSQLDSIHVLIDYIRIDDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJI1</accession>
    <name>A0A232FJI1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_013491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000156">
        <property type="protein sequence ID" value="OXU30467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FJI1"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF76">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1113"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1292"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1328"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1381"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="449"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="1185"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU30467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1426" mass="157386" checksum="2CA6DAFD63936ECB" modified="2017-10-25" version="1" fragment="single">GKKAGRMSSSSKCGFCGFHPKWLQNWATSRSFIAVYGLLGTVQSMAFIYIVVSLTSLEKRFKIPSRTTGLILSGNEISQILSVLLIYYGGSGHRPRWIAIGVGFSALSCLVLALPHAIYGPGQDALALTKEYMNATILTRGNEIKELPICSRNSQTESCNDGDLTDTSIVPRLLVFFSQFILGIGTTLYYGLGQTYMDDNTKKKNTPLLLGFTFALRTVGPAFGFVLGYLCLNIYIDPSLHPIIEKKDPRWLGAWWLGWIILGITMAVFAVLLSMFPHELRKTKRLKKKENALSESEVPLKIETAQPEKAPSVETTLTPVTEKPSLKDFPKTVKRILKNKLLMFNIFSGVFYVLSASSFMNFIAKYLEVQYQTSPGGGTVVTGPLSLLGIVLGFLISGIVIGKYKPAPRPLLFWNVLVGFAFFFGTIGFVFLGCDSGKIQGIDFDTKIINLTASCNAACNCENVKYSPVCHEASRTTFISACHAGCTSVINDTVFGQCSCVADLESSFRERSIVGASLHLVDDLSKTFQYNDNYVGGRVTVGPCKQDCFVPWIMFCALSTFINILGCSGKIGNVLLNFRCVEIRDKSLAQGLAMMMVSLFALIPGPIIFGTIMDSTCLVWDFSCQKKGNCWLYHRENFRYYVNVTSAALCFIGVLLDMVVCYLSKGIDLYGDEEEKEKRRVSALKNVELKLNNDDPKQSSVMRNSNKDDRPASNERNGPESKKLLKVPSTPTTPPSSPVKPTRAVDDLFRQLPITEETSCGIWCFRGPNLQRFANKKAYVFLYGVLGCIFSASYAYFNGTITTIEKRFKIPSKTTGFITVGNDISQLLVSVVLSYYAGKGHRPRWIAVGIYTVVLFCCLTMLPHFLYGPGEDALLLTKEYGAQAASNQTTTVIHDKQRKSLCLNRTNYDHCEEADGNFAPQVLLFIAQLVSGIGGSLYYTLGVSYMDDNIQKSKTPALISFSYFLRMLGPAIGYGLASFALKFYISPTLTPTITMQDPRWLGAWWLGWIILAILLFIFASILALFPKTLPRAAARKALALEKNKSSASIKDQEQEPELPASLGDMMRTFRRLLTNTTLMCNNLAAVFYFMGYMPYWIFMPKYIETQYKQSASVSSLITGTVGLVFSAFGILLSGLVISKYKPRARYLAGWNVMVGAISVLGMISYAFLGCPANDNQIAVADDGSLKTLMPCNEHCHCDYVTYNPVCSENGQTFISACHAGCKTVRVDGSGSKVYTDCSCIKPSLSQVFAQVSTNEAMTTTTTTQRAFIDPSVPYTLGSAVPGSCSIDCLDKFYIFLAVVCLLKFSGATGRASNFLVSVRCVDEKDKTVAMGFSLTIMSLFAFIPSPILFGFILDKTCLVWGKTCSGTGNCWLYNGETLRYLMNFTAATFVTMGTLFDVGVWYYVKDVKIFDEEVELEDIAEEPGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJV0</accession>
    <name>A0A232FJV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000143">
        <property type="protein sequence ID" value="OXU30597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJV0"/>
    <dbReference type="STRING" id="543379.A0A232FJV0"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF220">
        <property type="entry name" value="LD41874P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="93"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="431"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="628" mass="73037" checksum="16E06D7E4FAADA8C" modified="2017-10-25" version="1">MAEFQLNEGPLDAESKALAVKELRETEENVKNGIEKLRKLLEEDKTLYFRTDDDFLMIFLRPCKFYPESAHALMLRIAEFKQKNASLLDNLMPEDEKAAFLENNVVNVLKNRDHKRRRVLVVNAGKSWDPARVNADQMFRIFYLIHEAAILEPETQVHGVVVIMDFEGLSMKQVLGLTPSFSMRLLSFIQDAMPLRLKEVHMVKEPFLFNMVWQMFKPLVREKLKKRMFFHGSKMSSLHKHMLPSHLPKNYGGQLPEIDYTGADWYPVITKYEDHIKLPASKFSFQFLSLFHLHRAQGQFSRKRPTDQCTMSQDTLIEATKQLTLAEKLSSAPKLYIGKSEFTFDPNPLDEEWQARATKELRETPENVEEALNTLRELLKGEPDLNVPHDREYLQKFLRPCKWYAESTFELMKRFYKYRQSHPKYCDNLVPRNERTVLMSGTLTPLPKRTEDGVRVILVEGGKKWKPKELSLDQMFRGVILFLEAAIAEPKSQVAGVRVIIDMDGLTLTHVTYFTPSFAAAVVEFVQRCLPCRLKGVHIINQPFIFNMVFAFFKPFLQEKLRKRIHFHGTDRNSLKKYIDAKALPKQYGGECDFPDEPIGEPFVKYLNVFQEDFIASSKYGYPSKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKC0</accession>
    <name>A0A232FKC0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_015943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000077">
        <property type="protein sequence ID" value="OXU31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKC0"/>
    <dbReference type="STRING" id="543379.A0A232FKC0"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF35">
        <property type="entry name" value="IONOTROPIC RECEPTOR 68A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144683" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="11">
        <location>
            <begin position="364"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="708" mass="83159" checksum="1B7D0C6C2CC7648D" modified="2017-10-25" version="1">MYFLIVLILWLGTSLSVTDNRRLIYPASNKQLQTLVKLLIEEVAENSRCIVSMVDTYYRRKVDISQIKANKFLPTYRVLIRENEEFSPPRRRLLRILKESKHLGCDVYLIMMANGLQVTSLLRYAEEERLMNVQGKFLFVYDFRIFHVEMLYLWNRIINVIFIRRYVEFKRRSSNRQLHKYEWYDLNTIPFPARKKGLIVTRYIDTWYQNRFRYGINHFTAKTDDLRRQKLQVAVFEHVPAVTEDAQAYYKSQKDVGSNSKPLGIEFEMILIIANALNFKPDFYQPDNIQTERWGDSKNDTYTGLFGEAKEGNAVFYLGDLHYTSRHIQILDLSWPYNTECLTFLTLESLTENSWKLLILPFRLNTWLAVLFTLIFACATSFVFSRFYMRHVNVGENNDSDASKVFFKSKSMKVLEKRAVQAEEWKGLYLFTDPQNSVLYTYSMLLQVSLPSLPRAWSLRVFIGWWWIFSILIAVTYRASMTATLANAIDRVTIDTIPELVKSNVAVGSWNDETREFFINSSDPYLQKLSRRYVVTKDEQSALAAVANGTLCYYENVYVLQRERVKRQILEDELQKNGSQDKHKFQDHNLHVMEECVVNMPISLGMDKHSPLKHHVDKLVKRIIEAGFVEKWLSDITQQSKILELRGEGIADKALIDLDKLQGAVVALGIGYLISLLALAAETWHWRYVVMRHPNFNKYRMDLFYKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLE6</accession>
    <name>A0A232FLE6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_006479</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000080">
        <property type="protein sequence ID" value="OXU31167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FLE6"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="171"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="803"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="833"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="862"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="918"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="946"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="979"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1008"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1052"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1111"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1139"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1168"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1196"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="399"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1212"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1249"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU31167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1409" mass="162763" checksum="01024E54D7B25B92" modified="2017-10-25" version="1">MSNNSFLSMDFEECDSSIIDGTNAAADQSPALDEKNKHNNERSEVDSDTQEGDMEIASGAVPSTRNTNVREVIKMKKINLSDNEDHNYTDTQTEKSDNSNTGFTSNFIYSKVENSGKEKYIGLKISNLNDLKKAIPRLKLPTILSSTSLSPSSSVKKPTAVPIEVKQKLHKYCRACAGLKVPLINIFSVKGKQMRLAQQIQHLEDINEHDSLSTQMCMDCICDLRMSYKFFMQIKKAEIKLKSICDSFNNFPKTSEDDEMTDVFIKKETSMESSNYEVLDNEGIKSEAEDIDCTEMNEISSIGNDSFEEFDPDNPNYTDEVDSKKITESYIELDESTGSNINTDKSSKSETYSNNVMESETDLDKESETIIQDDIDKHNDSVYQYDESLDAYIKVEHSEGAQEDVEPENKLVESNTINASQTSESFIPLTKSSNTSKRKLSSGNISDDSNDKPNKIDFQKLKDLKIPKLDLQNSTKIKTQEDGVMYVTAKGSKPNEVLLIKVKKMNKPSEKKVEKTLGKKKGDAILHQKGYSRYEYANKKDNSIDEQIEQYKKKRVQILGEVANMTETDFDENLEAKVIGGEVSTEIEMEEQEDEMENTEEYVDNIEFSETPAFPSQHEAPLTKIQQRWKDIKKRHETIHKDLAEDCTDRLKSLLRQKDEDIQEFISYLKQRRIVVSRLKDEHIISLYEAKNHVLLEKLPLQFFATPEVDIDPFEFKEIFDCDFCNESFPSRDMEYEHSKIHDFKLMHYCEDCQQEFLTHKGKRSHNITCVQKLMCKYCDMILESKGKKRQHEQKHCDEQNGQLCDLCGEKFKHQGTLDQHVKSRHMQLEKIYKCPQCSKRFAFRTKLTFHLKSVHTTSRPYLCEDCGSDFKNPASLRHHRIRKHQPTNNKKECTVCHKMIPVYSMSKHMHTHKAYTIQCPHCDKMFKNTSTLKQHIRIHEDQRQYKCDMCGVGFNRRDGLRLHMKVHLKADSRGLKECSCQLCGEKFPNHSMLVIHRNRTHKDGRNYTCHICNRSMISTRSLEWHLAHIHNETMPGIVRDESSVDAETKRVSCYHCDKTFKTEMILRTHVKNTHTEKEPMKCLDCDLKFTSEVRLKHHMMIEHNRLEGTLACPHCPKRFVNQLRLKTHMISHSDERPFTCDICGFMLKTKIQLIKHKQNRHSNERPLQCRYCAWRCKQVSALVCHERTHTNERPYSCSVCKQKFKYLGDKNKHERRHESLGGSGFKRIVTGRNTNKSVKKKDSNSQEQDSEVEHEEYDAEQQEEEEYEEQVEGQVETFDETQIIKFNDNGEIINEESETSYDQMYVEDTSQDASDSSKIVIGMEEGTVYEEEVTADQIESEMITGNIINEHMLQSGTIHTIQPGTVVHLQQQDETGKIQVIPVMLSLPDLSDATAEVNLATASIMYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLG0</accession>
    <name>A0A232FLG0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000058">
        <property type="protein sequence ID" value="OXU31423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLG0"/>
    <dbReference type="OrthoDB" id="10669121at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="335" mass="37686" checksum="EF8C2B9A132B4F15" modified="2017-10-25" version="1">MEDLVDDRDVLLLARAKDLEHEYENLVRSLDAAYDAVRQINAAMSENRSEAKRVFQERLELLASRPSTNTTNNNRQNYDRINTVTHNAVTKDSIEIRSGNDAVSRKPQTVLVTGGDEKLTRYVIALAAKKNKGTTKSTASVVAAQNNSSRAASDAVVPSLIYYSQQKTATPQRVGIKGYVGDEHSYAEVDTKTGLVGHSVTQEEENKSAKRNETAEIEVDLSIVKSELDDESNDYEARLDSTVDDPSSSRDHSASDCATPTPSAITLTTMPKLKVIQQEAYEYKIRGRRKKKLEDPMDEEALTRKRVMTRNRMRRWRAKKRLEQVTDIITKNNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLW3</accession>
    <name>A0A232FLW3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_007901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000035">
        <property type="protein sequence ID" value="OXU31724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLW3"/>
    <dbReference type="STRING" id="543379.A0A232FLW3"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18243" checksum="E3763F22652DB15D" modified="2017-10-25" version="1">MLRLRCVHLVGECGTSAVINLNTTELGGVRAAPLWDSSQQQFVGMLTITDFIKILQMYYTSPSVTMDELEEHELDTWRKDLKLQFNIWYYCSHFSGVLTSRSSRTLLQNQILKYHLDLAMYPITVIVILALGPTLLMRDIILVRTMGRSDATDNNLKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMC4</accession>
    <name>A0A232FMC4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sortilin-related receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Low-density lipoprotein receptor relative with 11 ligand-binding repeats</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Sorting protein-related receptor containing LDLR class A repeats</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">TSAR_000711</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33 34">Alberta</strain>
            <tissue evidence="33">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
            <location evidence="7">Multivesicular body membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">trans-Golgi network membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Recycling endosome membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the LDLR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS10-related sortilin family. SORL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000039">
        <property type="protein sequence ID" value="OXU31670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FMC4"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000024">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057841">
        <property type="entry name" value="FN3_SORL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25814">
        <property type="entry name" value="fn3_SORL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="26" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="23 29" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0967">Endosome</keyword>
    <keyword evidence="25" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="22 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="15 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20 31" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="1973"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="30">
        <location>
            <begin position="826"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="30">
        <location>
            <begin position="871"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="32">
        <location>
            <begin position="1425"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="32">
        <location>
            <begin position="1525"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="32">
        <location>
            <begin position="1620"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="32">
        <location>
            <begin position="1712"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1018"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1025"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1037"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1057"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1064"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1076"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1096"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1103"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1115"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1159"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1202"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1244"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1256"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1293"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1300"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1312"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1354"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1382"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1389"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="29">
        <location>
            <begin position="1401"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00029896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00032450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="OXU31670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2070" mass="233082" checksum="88AF224F73071F21" modified="2017-10-25" version="1">MVLVNALNDSHQQLMVHWVGEGSDVIICLARDSNPLPRFFQTVQPAVAVNPSAVYISYDYGDTFQNKTDSFRVSDEPDAKYATLDKFYNHPTHNNLCVFADSANKLIFITHNHGHDIERIKLDFSPSEIAFYDNQEYDASALVLLVLDKTTSMRKLYMTTNRGKTWNLVHEYVKAFFWTNSRPKNLLIERTEPSGQNNVIDLGHNAWKWSKRNYTEVISNVEDFQIRGDYMFATKKPANNNTQGLDLFVSYKSQPFVPAQFDTDPGRREYHVADVSYDRIFVAVSHTETLVNLYISEIIDHRAAKFILSLPNILTFFPNNTWKDSWLSDVADEAFTELYKVEGLRGIYIASQVQGTPKLNSIGPEHLLSLISYDHGVTWNKVKAPESNHKGLYNQCNPETCSLHLSQKFSQLYPVSRAASIMSSKSAPGIIMATGVIGTSLKGHPALYVSRDAGLTWKQVLQDYYFFNMGDHGGVLVAVKYFKTRGETRDISYSIDEGETWQTLEFNEKMLRVYGLMTEPGENTTVFTMFGSGSGQHQWLIIKVDLSKVFARNCTDDDFKFWSPAAPKEISSTCVLGRKETYKRRSARANCYTGQNFDRPVKTEICPCDAVDYQCDFGFIRQSKPQWPSYTCVRNKSLENYDPYAVPATCAPGKFYNRTKGYFKIPDDDCVGGRAKVFEPDEIPCPMLELPEFLLVAQRERISRIDLKEQKLEVLPVHDLKNVIAIEFDIKNNCLYWADIVNDTIGRQCFKSGKSAPEILVETDLSSIEGMALDWVSNVLYFVDGVRMRIQIIRTDMSSMGRMRRTILGPNNVQKPRGIAVHPMAGYMFWTDWAPGNASVNRANLDGTNVKQLFHNRVEWPNGITIDHIAERIYWVDARQDYIGSSDFEGNGFKKIIHNDERVSHPFAVAVFKDNMYWDDWKQSMIFVADKDHGFGVSTIIGQLAGLMDLKVFAHSVQSGTNKCANNTLCSHICLGAPNDGYVCLCPDGMVMQDGKCMCPGGVTPYANSTCPRVANSCAANQFACDSGVCIPEFWKCDGDNDCGDHSDENYCNKVKCQPNTFTCDGEKCIPRYWVCDLDRDCKDGKDEMNCTYSNCTDSQFRCDNGRCISHRWLCDGEDDCRDGSDEKNCSTSIPPSTCKSDEISCKSDNNCVPKTWKCDGETDCEDASDEDDCTSVECEVWQFDCNASDKSHRCIYKSWVCDGDTDCQNGSDEANCTSSESHSPTPTPSLLPTNSCSEWMFMCQNKKCVPYWWKCDSVDDCGDDSDEMGCGFPDTSNSGTTAATTDEHPHVCREFQFQCFNGECIETSWMCDGSKDCSSGEDELYCSNGPIGCKEDQFKCFVDGSCVPLINICNGIQECPDGSDERGCDHHRPSPPPTTSCHTGFFPCDETRCFPLSAYCNGKQDCYDGFDESNCEKNNTRVYQVLNIGVDERSTNATTLFLYWWMPIPSNITFEFMPSIALAEPGAKWTNASRWVEDTEYQFNNLEPYTRYNMTVYVKLKGLPTIFPPARYLIVTTGEGVPSPPWNVTAVQRNGTRIEVTWQPPIHPNGQITGYRVYMTPPIPPAPVYPQQKTTVIIDDAFEAGKNYSFWVVAKNKEHESESSNVATITFDGSANIDHIEDLKVIDKTNHSITLNWKKIDSADGYNITPRGPPSYPLLDTYSTKSNTYVVDGLAPGTRYTFEVTATKKKYVGKASSITGMTKDQPLPTVTILEPHLLKSHGTTVKLSWDPPKGTRKVKWQYAVHYALNMQDVYKAPKLITTNLTATIRDLEACEYYIFAVGVKGDYGAGSLSQPVTVATHFNAKAPPKRLRITVTEMTLNKTKVFTLAATNETVLKHPFRDIKYGGRYNISISTDVEGAIPSPWVIYNAPPILPPHQLTVRFAEGNYEIYWQERQLPESIAKTTKYHYEVLVNEGERTINESTAAIFKTNQPPYIYQNAKLDKIYAFAVRLVTEEGYRNLSWTPPMNASSILSLAIPICLLVIALGAALAYFVIRHRRLSNSFTQFANSHYDTRRGQATFPGTVDAGLAEEEDSPVIRGFSDDEPLVIAVLSYQNTKKNEKNDNNNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNC1</accession>
    <name>A0A232FNC1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNC1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="37" mass="4222" checksum="24B8A813056525B0" modified="2017-10-25" version="1">MLRLESTQFIQILPISGNIIVNISTRAIFNNTLKTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED90</accession>
    <name>A0A232ED90_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007487">
        <property type="protein sequence ID" value="OXU16309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED90"/>
    <dbReference type="STRING" id="543379.A0A232ED90"/>
    <dbReference type="OrthoDB" id="8194903at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="67057" checksum="38994379E974C5DA" modified="2017-10-25" version="1">MSRRKGKGYKNWMDPTCKKRIPKSTEYLYKHKMLKSLLENSEISEEENHDSLPHDIRSPVSLPVQNLDYQSEDFTHIGENCFIYSEMENNNNEDWINAFTNNNSVQSEICEESVQSESCEENTVYEEENNKSITKQFKKNQYLNKKLQKKTNVRYGEIILMCIMLGVRHSLTWTAMLDIFNLINKLFDEDVIHLSKYKLFNFFPENKKWFNYHIYCPVCKIYIGNRSHFSNTIVCPSCEHVIENVKKSPYFLTLNIKSQLKQLLDNPMINKHLQYKYIRQKQDSKNIEDVYDGDLYEYLSLPGNVLHDKWNFSYILNTDGCQTSDSSKVSAWPVYLKINELPPKIRDKHMILVGLWVNEEKPVLNTFLQPIITELNVIATEGIEWKMDDETIKSKFIALCCCVDSVCRCSLLNMKQFNGIFGCTFCYHPTENVEGTRKYPIDENVHLLRTHDKIVQDMILTRSVNSQSGQIETQEVNGVKGPSILLNLEYFNLSDGMTPDSMHCVYLGVTEQYTNLILGRCHEPYYVGAPNDLSVIDARLLSFKSPKIITRTCRSLTNRNSWKASEWLILSYLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEI1</accession>
    <name>A0A232EEI1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005371">
        <property type="protein sequence ID" value="OXU16722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEI1"/>
    <dbReference type="STRING" id="543379.A0A232EEI1"/>
    <dbReference type="OrthoDB" id="8033893at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="4">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="400"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU16722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="602" mass="66938" checksum="83F9B1C990320B03" modified="2017-10-25" version="1">MSAKCSLNTFWRSQPVLWFLQREALFSTHNVMDDTAQYHLAIGAIDPATLEDLQNVIANLPSTTTDKYKTLKEAIIKRTTESPDSKLLKLLTNLELGDSKPSQLWRKMKSMAGDKILDPALKVMWLALLPKPAQTYLSVFKIDEMEDLLEAADKLITHNMQVSSVSTTENPSNNSSGYCTPVCPVSSVQQQLAALQPAVTQLIAITKSSIERAPQAENSQRGRGRACSKSRQRTAAGKTPAENRLFIEDPSTSISFLVDTGSVVSLIPKTHVNRSLEKQLLMLHAANQTRISTYGKEQLEVIIVDIKEQRIIDAKTLLSMPSALDATAVRTVSTIEAIQQPDGPLAKRYQALMKEFEDVFGDITPACILSMPVKHVINTTGPPVAERPGSGKWASPLYMVPKKKGWRAAGDYRGLNAITIPDRYPLPIILQSSPGNVFSTVDLENAFYQIPIDEDNIEKTVVTTPFGLFEFLGTSLGLKNATQTMQQAMDLVLRKLPFAKFYVDDIFIASKDHEEHLQHLRQLLEALRQAKLKVSKESFQPPSAKVEAIKSYPLPNTATELRRFLGIHNYYRRCLPHAARNQAPLHDLLKGLSKKAKLKCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFG3</accession>
    <name>A0A232EFG3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSAR_000665</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Alberta</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005021">
        <property type="protein sequence ID" value="OXU17099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFG3"/>
    <dbReference type="STRING" id="543379.A0A232EFG3"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXU17099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119666" checksum="59020B15E058EFBF" modified="2017-10-25" version="1">MAKEIRNKLPLVGKQPSSGHLAPKKYTDEQIDDLYHELETQDHVIPIQRLCEKLNTSVSQGMSSENAAQVYAENGPNSLSPTKVTPEYIKFLKCLYGGFAVLLWVCALLCFVLYGVEIITGHEEEGIEWFGVIIVVICLISGVFAYIQESKNTKVMESFKRMVPVIATVLRDGIRLQLPAEEVVVGDLVEIRLGDKIPADIRIIECHGLRVENSSITGESEPTTRTDYPTDNNPLESKNVAFFSSYAVAGNGKGIVIATGDDTMIGRLAGLTTQLTKTETPIAKEIRHFVHLIMFVAIICGLVFFLLSLMVEGDIVKAFTYLLGIVIANVPEVLLITVTTSLTLTAKKMADKNCLVKNLEAVETLGSTSTICSDKTGTLTQNKMTVSNIWFGNTRFNFPANTMLGVERDLLLEKPAFNNFVKDATLCLRAEFKDDSESAQYTLIEDRLVMGDASETGDLLRLVDRINERSLVCYRHRNSAGILKFCEHIHPTKSFRAAYPKVAEIPFSSVTKYQLSIHKDVNGFIVIMKGAPEVIMDFCSTMMTAEGTTREMTPADLELSRKACTEMGYLGERVLAYCDYVLPVDPYDSEYVFNTSSPENYNFPTSGYRFVGLVSLQDPPRPFVYEAVHKCRTAGIKVIMVTGDHPVTAIAIAKKVGIIGEGHETRYERNLLLDKTFSQKSGSEEEAIVVTGSELRNMNEEELDYIIRSYEEIVFARTSPQQKLLIVESCQRLGEIVAVTGKIGRVDTASEYNANSDDELNTGDGVNDSPALRKADIGVAMGIAGSDVAKNAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSSVPEMLPMLASIIFSIPLPFVIELVLCIDIGTDLLPAVALAYEKAESDIMRRAPRNPQYDKLVNKRLISMTYGQIGMTQAMAGFYTYFSILMYHGFLPKDLFGLRVDWENRAINDLKDSYGQTWDYQSRMDLLNEARTGYFLSIVITQMIDLIMCKTRKNSIFQQGMDNWSLNFAFVFEAILTSILLYVPGTEKVLKTMPLDLFWYWPCLPLGLFLWTYDELRRLWIRTHPGGFIERETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFK9</accession>
    <name>A0A232EFK9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004968">
        <property type="protein sequence ID" value="OXU17159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFK9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="68" mass="7112" checksum="3D9A33505964ADDA" modified="2017-10-25" version="1">MYVLSDNRSGLATVATGTNTITATTNSKVMTAAAQRIDQVKLVVVKPNRSRKKPTALTVLGIAVANPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFL9</accession>
    <name>A0A232EFL9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_015243</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004963">
        <property type="protein sequence ID" value="OXU17169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFL9"/>
    <dbReference type="STRING" id="543379.A0A232EFL9"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000033">
        <property type="entry name" value="paraplegin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="344"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="750"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU17169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="789" mass="87946" checksum="AC56E27C0E795FA5" modified="2017-10-25" version="1">MQNVLKSTNRSMFRSHVNMLNCLHRHMTKNNAKLQRCLNSNQISRLFGSMSHNTICQMQREYRAVHAMLVRSGLSDTTSICQLNHCRALSKSCARSNQSNPTNPSNPNGPKDPASNENKDQNKKNNEKKAREMMLKLAAWAMFCYMSTIWLLYFFTGKSAEEEESPRFVSWNEFVHQMLAKGEVKQLIVRPELDMVTIILHDGAVIKGKKSTFKTYHMVTPNAAKIEERVREAEQQLGIKPEMGIPVIYDRGNTAAVHLAVTVALTILFFALISRFSSMRGQFGANMFTQMTRAKFTLVDPLTGIGKGVRFADVAGLQEAKTEIMEFVDYLKSPDRYKTLGAKVPRGALLLGPPGCGKTLLAKAVATEANVPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPSIIYIDEIDAIGKKRSESADRGTGQSTDEGEQTLNQLLTEMDGMSSNQEVIVLASTNRAEVLDKALLRPGRFDRHILIDLPTLIERRQIFEQHLKGIALEHKPSTYSNRLAFLTPGFSGADIANACNEAALHAARLKKTMVTGDDLLYAVDRVVAGIEKRDNTIAPSEKRVVAYHEAGHALVGWLLEHTDALLKVTIVPRTNRALGFSQFTSSDQKLYTSEQLFERMCMTLGGRVAESLTFNKITTGAQNDLEKVTKIAYAQVQQYGMDQIVGPLSFHPEQTDTNTRKPYSKKLANLMDQEARTIITQAYKRTEQLLLENQDKLKLLAEGLLQKETLTYEEVEKLIGPPPFGKKNLVEPADFENSVPVPEPPKSESPPPQPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFV0</accession>
    <name>A0A232EFV0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004931">
        <property type="protein sequence ID" value="OXU17223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFV0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7628" checksum="7FDD9824C5FFC194" modified="2017-10-25" version="1">MQKFTFDELRIALPCVVERLEKLEACVTRFVNDIDESLVNIIICEIAAFKLFNIYREIYITIVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGK0</accession>
    <name>A0A232EGK0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004752">
        <property type="protein sequence ID" value="OXU17466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGK0"/>
    <dbReference type="STRING" id="543379.A0A232EGK0"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="113" mass="12903" checksum="B348ABB2A8E71F21" modified="2017-10-25" version="1">MSDLFSNASNYDNEHKPSAGNSELEEFIMVEKQKAQFNAQVTIKKFLTSYRQTIALSTKIHEFSDLCWDKCIDKPGSKLDGRTETCLVNCVNRFIDVSLLITNRFTQMLQKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHC7</accession>
    <name>A0A232EHC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endosome-associated-trafficking regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENTR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004519">
        <property type="protein sequence ID" value="OXU17777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHC7"/>
    <dbReference type="OrthoDB" id="6499155at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903566">
        <property type="term" value="P:positive regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026757">
        <property type="entry name" value="ENTR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31259">
        <property type="entry name" value="ENDOSOME-ASSOCIATED TRAFFICKING REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31259:SF3">
        <property type="entry name" value="ENDOSOME-ASSOCIATED-TRAFFICKING REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="286"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU17777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="475" mass="52820" checksum="DA32DFE07E78603F" modified="2017-10-25" version="1">MFPSSSSASSADEAEVPATAELESSSGARPRKPRTPSDEWKDKAKTKPWRKGKSSTRREESLFSLKQFLKNDNQTNHQFAGARPKVYESQSRTPEPSENHDKGKYPRNPTELPDFVQDHLVIEQCFLGDKASSNMASVEVDNLPDFALNSVEQRHIRYLKSHSAPCDRWKKNSEGSGDLSFDLTDHLDKGPSNSPHPSSLDLPKLDVIDGESADVPESLGFPFDLQILRGTESNVNADVAANHPLPEGIPNTTKLLPDFLSDAPIRTRGTPMSDRPDCSSSSDSMNQWLSMENERLRNELQIARRQASERSLRIETLEAELLSRGQSDHTESANFEKAMEQVEDNLKRSTKRAINAESTVASLKKEIDSLSIEIMMLQTENRELRAAMGVESNGCRNTNPDRRIRRLADDLRLAASTAEVSLRQLMSGVNNLRVLASALENVDKIEDRTKDFLPDFDEDNAAGPALLAVSSSYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHH9</accession>
    <name>A0A232EHH9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004485">
        <property type="protein sequence ID" value="OXU17829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHH9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14373" checksum="D671D6C8F2DE866C" modified="2017-10-25" version="1">MSRINLNNPNYYDPPPSYEDICGRSVAPKNNRIGEHEKITRSRGDTATPIYGVTECSVRPIGDGTEDFSRTIPLPEIEQHHNQQTAHLSHTPSNQRFVIIFLTLAILLMTFTVIVMCHLRTRDNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI42</accession>
    <name>A0A232EI42_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein stoned-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004328">
        <property type="protein sequence ID" value="OXU18040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI42"/>
    <dbReference type="STRING" id="543379.A0A232EI42"/>
    <dbReference type="OrthoDB" id="6363808at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="99298" checksum="9ECF909673087362" modified="2017-10-25" version="1">MHKLAKGLKKKKKGKKGKKGEDDEEFDPEELERYRRERAEAQQKLAEAASSGEASAAAGGNDEWKKFQALTSGVDSILKKTQDDLDRIKSTSFFQRKAPEPEPDPEDNPEVQAKKQELAKKYVGFDKDGNPIELKEEPEDSKVKALPVTEDGIVELPDDDDEHEDSADEDIFDTTYVDALQNIEVELAYIPDSPTQEELGDDPFDTSNADKVLKVVDKTGKKLVSLGNAVEVLSGRVDHVSTCKIGRNRPRPKNQDLLGDFDSEEPIVTVDNPDADAEPVKVEKTLLDDDSDLPDIPIDLTKLPPILTRPVTPATNGDNQTEENKPLDISEFELEPKTLLDEIPVLDDEEFDLDGPVEPVVLEEADDPFAEKEPEKLDFQEEIIEASFEAATFVNEDDPFDTTIADNLVPGKTELKFIEKELEDFPVSEVSISLTDPCGLHRDYETGLLKAKAQAALSVAKKDLLGGSNTDLSQLVDQPIKPVEEISYVDPFDTSTIQELPPGKTELKFLEKELLGEVKKSALDDLDDDDFDPRAEEAPAPDKKIPPPPRPPSISRGSTPTPEVQFQVKEEDFEFQAQAVTKGRKPSRPEALDISPKTVAFELPTPSKKPDLLASSEEEKSLPGKPLTPYYPQKSLDEVLPPEQELDETEVDPFDTSFVPSTAPGKTELKLIESELLQEDPVATGLTHSLSDHDFDPRSGQPAQAQNRRQSDFGTVTGRSNVVKSSDVIESLINKRKALDKRQDSILDTDVEVPVEPLAPNVKPSTIEEEVELSYKDPFDTSHATDILPGKAELKLLENELSQVPEPAPIKLHPVIEQVIKKSIVEEDPDFDPRAEEAKDKDILCLDTQEVPSGKILTPLQDSDFAAEDIDPFDTSFASVDPTKTELKLLESELINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIG7</accession>
    <name>A0A232EIG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_007935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004286">
        <property type="protein sequence ID" value="OXU18101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIG7"/>
    <dbReference type="STRING" id="543379.A0A232EIG7"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="333"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="631" mass="71577" checksum="D249A72ABE32725C" modified="2017-10-25" version="1">MALNVPKIKFYNGNEIPAFGLGTWKSKPGEVTQAVKDAIDIGYRHLDCAHVYGNEKEVGAAIAAKIAEGVIKREDLFITSKLWNTYHKTELVEVNLRKSLTDLGVEYLDLYLIHWPIAYKDGPTNFPQTPEGKPLLDVDVDYLDTWKGMEAVLAKGLVKNIGVSNFNSEQIDRLIKNSKVKPVTNQVECHPYLNQRKLSDFCKQRDIVITAYSPLGSPDRPWAKPEDPKLMDDKKLIELSKKYNKSPAQVLIRYQLDLGHVVIPKSVTKSRILENSQVFDFKLAQEDIAYIDTFDCNGRICPMTGSEPSPHYPFHIPKIESTTFYNGNKVPILGLGTWKSKGGTAVEVIKDAVRIGYHHIDTSPVYGNEKEIGEAITALLKEGVVKREDLFVTSKLWNTRHRTDLVEPALRKTLSDLNLEYLDLYLIHWPVAFKELEEPFPEGPDGKVQFSDVDYVETWKAMEQILEKGLAKNIGVSNFNSKQLARILENCKVKPVTNQVECHPYLPQVKLSEFCKSKGILITAYSPLGSPDRPWAQPGDPSLLEDPKVKGIAEKYNKTPAQVVLRYQVQRGHIVIPKSASKVRLQENTNIFDFQLSEDDIKLLHTFDRKWRVCPMNSAAEHKDYPFNEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIJ9</accession>
    <name>A0A232EIJ9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004233">
        <property type="protein sequence ID" value="OXU18164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIJ9"/>
    <dbReference type="STRING" id="543379.A0A232EIJ9"/>
    <dbReference type="OrthoDB" id="10040691at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006627">
        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028184">
        <property type="entry name" value="VGLL4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604:SF7">
        <property type="entry name" value="TONDU-DOMAIN-CONTAINING GROWTH INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17604">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8179" checksum="270A3D52B766C798" modified="2017-10-25" version="1">MRQAGVASDPAIDEHFKRSLGLKEYAAVFNAATTDKETGLSASLYSLFPVDDHFAKALGETWTRLQATSRSKDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIY3</accession>
    <name>A0A232EIY3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004145">
        <property type="protein sequence ID" value="OXU18304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIY3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8811" checksum="6E6436F55EACEC79" modified="2017-10-25" version="1">MHTFLNLHDKTVFTFKALCLAIIFFIPRENNIDASCRNVNTSICVKFVITTVLMRFSKALSISIQRTQSVCWISAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ10</accession>
    <name>A0A232EJ10_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004118">
        <property type="protein sequence ID" value="OXU18343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ10"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="43" mass="5005" checksum="F7A0EFDCA5F229EE" modified="2017-10-25" version="1">MRSHSKIAKNDFFGSNSNSMHSIKKKLDRKVVNLEKIQIFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELB9</accession>
    <name>A0A232ELB9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_013588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003584">
        <property type="protein sequence ID" value="OXU19150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELB9"/>
    <dbReference type="STRING" id="543379.A0A232ELB9"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="27488" checksum="9A3075B0102604A2" modified="2017-10-25" version="1">MDIEELRESGDEQDEQDDRENGREEEREEGQEEQDERQEEEQRDEVDEQDDEVQVLENDEKLEEPDVDVKSRQENRANSRHKSSKQSRGYKVQSRATTPQNQSRTSNNIQPKRWRSANAFVNFVQDFKQDYPDMITGRNIFQTCGERWKSMTDEQKQPYIAAANTVKRLKNRKIGESSDQQSKKSVTRVSKRKAETKRKETSQKRSKANNQDAMSNSDTDTATTTVRSSMSDPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELJ9</accession>
    <name>A0A232ELJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Alpha-amylase</fullName>
            <ecNumber evidence="6 15">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_000621</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="NNAY01003543">
        <property type="protein sequence ID" value="OXU19234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELJ9"/>
    <dbReference type="STRING" id="543379.A0A232ELJ9"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325591" description="Alpha-amylase" evidence="17">
        <location>
            <begin position="26"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="41"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="18">
        <location>
            <begin position="437"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU19234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="527" mass="58492" checksum="59DF51FF2E6C58F7" modified="2017-10-25" version="1">MNNKNLLTKLAVASLLLLQVHWALSYDPAAYKDPHYVDGRTTMVHLFEWKFKDIAKECERFLGPMGFAGVQVSPINENLVIPGRPWYERYQPMSYKIITRSGNEDEFADMVNRCNKVGVRIYVDAVINHMTMGAQATAVGTGGSSAEPAKRLFPGVPYGPSDFNAPCTIANYQNGTEVRDCDLSGLQDLNQGKEYVREKIVEFFNRAIDHGIAGFRVPIVPNVHRIDAAKHMWPADLKAIYGGTKNLRSDVFGENKRPFIFQEVIDVSGNEGVKKWQYNDLGDVIEFSFGIQIGSFFRGWEDLSHLQHWGFSDRGLLPSNDVVVMVDNHDNQRGHGAGGDAILNYKNPRLYKMAITFMLAHPYGHTRVMSSFDFSDPSQGPPADSKGNIISPDPITGNVASGADANACGHGWVCEHRWSQIYGMVGFRNVVQNETLINWWSNGQNQIAFSRGNRGFAAFNGQYGVDLKQELQTGLPAGDYCDVISGRKVNGKCTGKTVKVNNDGKAYIEILKDEADGALVIHAETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM48</accession>
    <name>A0A232EM48_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Toll-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tollip family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003423">
        <property type="protein sequence ID" value="OXU19435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM48"/>
    <dbReference type="STRING" id="543379.A0A232EM48"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04016">
        <property type="entry name" value="C2_Tollip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000036">
        <property type="entry name" value="Toll-interacting protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037301">
        <property type="entry name" value="Tollip_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="43"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="7">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31516" checksum="98097D9C61FB1AE6" modified="2017-10-25" version="1">METAKNLEQCEEWRKRAFLGPLPPSFLRIENTWSGNQQEEADRQAAFALQQMQNQTMSLMGRLTITVVQAKLIKNYGFTNMDPYVRLRVGHTIYETHTDRKGGKNPHWNKVIQVFLPPGVNKIYVEIYDECSFTMDELIAWGHIDIPSQVIEKGTTYEDWYLLSGKQGDNLEGSINLVLSYHARNPKAYMEMRPPVVMVPSTNMVGSIQPFAPVNVYTAPPVNPVPPVPASSLPNAEIELKQISEMFPNIDKEVIKSVYDANNGKKDTTINSLLQMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM83</accession>
    <name>A0A232EM83_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003399">
        <property type="protein sequence ID" value="OXU19473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM83"/>
    <dbReference type="STRING" id="543379.A0A232EM83"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF36">
        <property type="entry name" value="NIEMANN-PICK TYPE C-2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="6">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="144" mass="15657" checksum="BB4BCF4571A27B3A" modified="2017-10-25" version="1" fragment="single">FIIAAFLVASSTQSTPFKTCKDGAAPKDVRVAGCTKNPCSFIRGRNVSAEWDFSIPEDTKALKPRVRATVLGATVNYPFPQKDACSTLTNAKCPLETGEDVTYQLSMPILKSYPKIPLTVEFAFLDDNDKVVVCFSLSAKVADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMR7</accession>
    <name>A0A232EMR7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_014865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003318">
        <property type="protein sequence ID" value="OXU19631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMR7"/>
    <dbReference type="STRING" id="543379.A0A232EMR7"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21380">
        <property type="entry name" value="CTWD_Cns1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="273"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="386" mass="45476" checksum="C877F9C528661CBD" modified="2017-10-25" version="1">MSEKQDDQPNKKAWTEAERLELAAKLDKDLEDYIDNLDKKSYSEGWPEDRWQEEMEKHPFFMTQLPENPTEVSPLIEGLQQLKYSEEYNTPNELAQSYKEDGNFNYKHKKYRLAILCFSKGISSKCENTELMAQLYNNRALAQFKLQNYRSGLNDSKQALKLKPDYLKPLHTAAKCCFKVKNYDECVSYCDQVLNMLEQKNQIDYEIVTLRAKAVKEKKIKLRDIRLQELKEKKGDKIREEIIEAIKASKIRTDNSDVFYDSQCHVHLNETGEYLVWPVIFAYPVNNQTDFIQNFQEDTLLIEQLEEMFKESPAWDTKQAYRISGTENTLNVYYEGVDRKPYKVDVNKPLGSILQEEKFIVKNGTPWFFILLADSKEEESFLKAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENE4</accession>
    <name>A0A232ENE4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003181">
        <property type="protein sequence ID" value="OXU19858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENE4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="9001" checksum="6168B57F87C28515" modified="2017-10-25" version="1">MTYFVKTIQLNLLCFNVRQNSVTERMTRRWKKNKIVGCNVSRSGDKGYGWILGPELRVGKNADELNFWQVGPVKWPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENS9</accession>
    <name>A0A232ENS9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-G-associated kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003085">
        <property type="protein sequence ID" value="OXU20010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENS9"/>
    <dbReference type="STRING" id="543379.A0A232ENS9"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000369">
        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF105">
        <property type="entry name" value="CYCLIN-G-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="8">
        <location>
            <begin position="429"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="9">
        <location>
            <begin position="608"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="786"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="914"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="961"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU20010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1205" mass="130565" checksum="FB4937AF113B985F" modified="2017-10-25" version="1">MSDYLKSAFGYLNGAGGAAGSGGNDYVGQVIEISGVKLRVNRLIAEGGWALVFGVEDVSTGKEYALKRMIAVDEEARKTILQEIETLKSLTNHPNIIQFLCVQQVNREGSKGTEYLLVTELCAGGTVADILRSIPVNSLSVAQICRIAYQATKAVHHMHNQQPQPFIHRDIKLENFLVGSDGLIKLCDFGSTTVQQILPDTSWNAQKRAQLEDHMAKYTTPMYRAPEMMDTWNNEPIGPPVDCWALGCILYSLVTLRHPFPEGNKLAIVNGKYPPLPAHPRLGCFHEMIKGCLQVSPTQRLTTSALLERLAAIAESNGFDPREPAKVEVAPAAAVAPPKPPPPTRPAPPPPATVPVSAHGGGPPPRPSPPVGAAGAPPPRPAPVHPHQGLPHQKLPGHQSSGLFSSLKGGAGSLFRNIKDTSSKVMQTVQNSMARTELDASYLTSRILVMPYPADGIESAYRANHVEDVRAFLQARHPPPTKIQFYNLSRGRPNVVRLIGRHIDCAFAYASSEANAPLLSAIYQICQDIYRYLDVDVHHAVVLYCNDGLRASAVVACALLLYAGVLKSAEEAIHMFTTRRCQPPQLQPSELRIIEYMASLVNGRLPHMKPLVLRSLLVQPVPLFTRARDGCRPYVEIYSNGAMVFSTKRAEYEEMKLYGMMEGKVCLILGDATVRGDITMVVYHARQQLGRVIGIKIAALHFHTGYVSLTDSCLVFEKKDLDDTPEIGGMFKVTVNAMIGEDSAKFTRAPAPWEAEDEHTGKLQPDPLFGSTLEMEETLENFRTVNGSDVRIPKETIPGPEAEPLVDQSGTSPSLSDEPIRPPRRPSGEPPHIAPTSHTEPSFAEADLLNLGMPSSNTQVPSASANLDIFGSSSSQAEAASSVDSNNDLLGGFGAFTSAAPPSTPIVNEPVTNDLLFGQTNGKPGDMGDLLFGQSGQSAPRPTPTTDDLFDPFGSAVKDNFLGNWTQPSAQAKTPSGDEGFPRNSSVPNFAAQKQDPFANLAGAMGAGLTSSWNGTPRESNTPQSASPAAAGTPVHSSPRMHKPVTPINETTTGSSVAQEKTAKSGDAFEDLLGSQGYNFFSSRKAEKDSPKTINQMRKVEAAKTMDPDKMKVTEWTEGKKGNLRALLCSMHTILWDGCKWQKCEMHMLVSAADVKKSYRKACLAVHPDKQAGTENENMAKLIFMELNNAWSTFENDASQQNLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP94</accession>
    <name>A0A232EP94_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002984">
        <property type="protein sequence ID" value="OXU20174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP94"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="14275" checksum="906C67264137652D" modified="2017-10-25" version="1">MTAKPSEVGEADEEVVVDSLDPSYPCHGIAGSSIHVDGRCVICQQTSTSPAAMDVKRMATGVQISYRVISAEDEPSPGGCIPCHREDWDEPEESCLICGQSLSDSATCLRLSGTEVSFISHAAMYIEYILIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPF1</accession>
    <name>A0A232EPF1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002947">
        <property type="protein sequence ID" value="OXU20240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPF1"/>
    <dbReference type="STRING" id="543379.A0A232EPF1"/>
    <dbReference type="OrthoDB" id="8197458at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="176" mass="19412" checksum="6F71E3E5A84342D3" modified="2017-10-25" version="1">MTMDGMEVIGSHAHPAATSPFLLSSPPLSHHHATFNVQTVQLSFDACLTYNTSTTCEQHQRITDNPELRQLNIEQPSQLLDKSVSIKKRRFQRTNCDGNNKECTVECQDVEPSSDEKDKPGDLNTPVTTSSDLPSFFGPAALVEPPPISGNYLHILEIGTACQDLPKLPVATRCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPJ7</accession>
    <name>A0A232EPJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_016949</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01002948">
        <property type="protein sequence ID" value="OXU20236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPJ7"/>
    <dbReference type="STRING" id="543379.A0A232EPJ7"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="354"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="429"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU20236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="506" mass="55821" checksum="881C44793A9840F7" modified="2017-10-25" version="1">MVVRQYTEELKYLEKINANCWKIKKGFQPNMKVEGVFYVNNTLEKLMLDELKNACRPGVVGGFLPGVKQIANVAALPGIVGRSVGLPDVHSGYGFAIGNMAAFDMNDPKSIISPGGVGFDINCGVRLLRTNLFEKDVQPVKEQLAQSMFDHIPVGVGSKGIIPMNARDLEEALEMGMDWSLREGYIWAEDKEHCEEYGRMLQADPSKVSMRAKKRGLPQLGTLGAGNHYAEIQVVEEIYNKSAASKMGIEEKGQVCVMIHSGSRGFGHQVATDALVQMEKAMKRDNIEVNDRQLACAHINSQEGQDYLKSMAAAANFAWVNRSSMTFLSRQAFAKQFNMSPDDLDMHVIYDVSHNVAKVEEHMVDGKQKTLLVHRKGSTRAFPPHHPLIPVDYQLTGQPVLIGGTMGTCSYVLTGTEQGMNETFGSTCHGAGRALSRAKSRRKLDYQEVLNKLEDMGISIRVASPKLVMEEAPESYKNVTDVVNTCHDAGISKKCIKLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPP9</accession>
    <name>A0A232EPP9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002899">
        <property type="protein sequence ID" value="OXU20359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPP9"/>
    <dbReference type="STRING" id="543379.A0A232EPP9"/>
    <dbReference type="OrthoDB" id="10042249at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="659"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="735" mass="82773" checksum="6FDE3951D73E5359" modified="2017-10-25" version="1">MSRENLERAINFGAKYGKLSFEISSQSSDDSNLSLSDNASHCANTPSSYNASLYPSYNSNISKTRKTASIYKPKYHAILQDDVTVKQVHSDLPNVKRFQQHIAEHIDDNNDTVIEAIDLTLHKFRNHQDAEPLIEDDQTIVEAIDLSSHKFRHHRCSPGIRQEPELSRKRCYNELIMAELAFEQTPHYNTISPPQMSPGPFLGNTRLVEVKQPRLDLMHGEDRQILDTSCEYKAMPTELRISVQSSSPTLDKQSYLNSAVSTDVHLSSNSSDLLPFSLTLSVPCENSLNQPANSFHDEPINLYVPDPERDTTSAHQPEQLERLQHINPINQISDLSYFSRPSSLPSGPGTFESINHNGIAPTVHTSALTSPEILRSKKSYGQSYLNGYVYTYLGLACSTELFYCTYNRPQPMYAKHYAGFSMYSEWEKSKGTLISLEFGRFDSRNRPAGYTLAYTRSADILTPSSWQSNSPASPDKKLESHDQDINKSDEVQNQLEQSQQLPLEQSEQQSSIDLGEKPLNLPTTECIVEKQQEPCASSEIVVAVTEFKSESSFNTSRSEMLREGETFQPTVHNVNNYISISEDAPSVCKICNKVFKEASKLRTHMPIHFVGRPFRCESCKISFRTKSLLMKHEKSADHQNTTITNSTSGVATSSDPRPFKCIDCALAFRKHGVLAKHFRSKTHIMKLECLQKLPFDTYAELEKGGMNLNEIDTTDCDTSLASLRIMAETLFGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPT5</accession>
    <name>A0A232EPT5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002909">
        <property type="protein sequence ID" value="OXU20342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPT5"/>
    <dbReference type="STRING" id="543379.A0A232EPT5"/>
    <dbReference type="OrthoDB" id="47883at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF13">
        <property type="entry name" value="LD14533P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37758" checksum="98B96EE5505A1C60" modified="2017-10-25" version="1">MSQKAQHLEVIRESFLLLAEDFLRKGHSIEDLKNVTKIRRKPSKSIFRHFYSKKLILVILLPLLYSIVVERFGIDFLMQYTQNTRCLVPNNYLVWEFTRPVSNCDFCRGVNSALVLNNLTKEEFQKYAYSSKPIIVKKAASHWVASKVFSLQFFRSLYEQIHGAYESVEEECQFLHFRSNFANLKEVFSMSEQRAMNLPGEEAWYIGWKNCHPQILEIMKKFYEPPHFLPDDAEIPNTNYIFLGYEQGAVMHLDYISRLMWQGQIIGSKTWTVAPTPECEDVCESFSFFVDTGDVILLDTRIWYHGTQVENGQFSLTVTSEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPY4</accession>
    <name>A0A232EPY4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002868">
        <property type="protein sequence ID" value="OXU20413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPY4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11715" checksum="AAC04792A978524F" modified="2017-10-25" version="1">MTAYNIWVILRNIFQQRYIGPIDAVLEQGVDIQAYYAIKFGAFDKKINWVHEFQGKDKITELRNIFQQRYIGPIDAVLEQGVDIQAVQPPSPVLCNKIWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ65</accession>
    <name>A0A232EQ65_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002821">
        <property type="protein sequence ID" value="OXU20493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ65"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12075" checksum="D3095286B0FECC24" modified="2017-10-25" version="1" fragment="single">DCDSTKPIAEHQCKCFDLRVSTSYARITDLLSYIILVRQMLIGRSLPRFVKFHTSLNRHRGFKKPENDPQTAFCTSNLLLYSCIRSASTRAISLYASLTECVQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERD3</accession>
    <name>A0A232ERD3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002620">
        <property type="protein sequence ID" value="OXU20924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERD3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="27" mass="3215" checksum="39180EBE307C6DF4" modified="2017-10-25" version="1">MRCFKLLFRISIVKKLIHIGGQTRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERE0</accession>
    <name>A0A232ERE0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002633">
        <property type="protein sequence ID" value="OXU20892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERE0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6974" checksum="BE396B2532A358FF" modified="2017-10-25" version="1">MYKKEKLELSQQLIFQDYYNYTTLLYAPSSRINNTPFPHSIVCSNVLGYLIAAKDLNKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERM4</accession>
    <name>A0A232ERM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002587">
        <property type="protein sequence ID" value="OXU20981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERM4"/>
    <dbReference type="STRING" id="543379.A0A232ERM4"/>
    <dbReference type="OrthoDB" id="5957963at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF44">
        <property type="entry name" value="SORTING NEXIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="93"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="301"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="510"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU20981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="97763" checksum="46CC05303DDAE3BD" modified="2017-10-25" version="1">MVNDEVIYFIASVALLFVIIAAVFDSLLWAIFLSLVYIIGFVWGIQVIQIIRTSVFSKEKSPVSVDESCGVCGNNQCKRHRRSPHLNPVPKVPKGFDVALERLLEEILQTYVCTWYSDLSSNEAFVQQLRLAIATAATNITGRLYKADLSHIIFNHLIPIAVHHARDWQELKKRAKDLGGTPTDHIADFLGSKIHPAAYSREAELNYLRGLVGALLPHLLPAIHVSTNNQVILREVLANWVLLPAIDALADPDNLNMLITLCTHHEGKFSQSIDTIYVPMLQTWISNPQKNQSISNTLKPSLEEVLNDPELLYMFMQHIKDSGLVNLLQFCLDIDDLSKRMLNPEITPEIEETLYIDAQNIYTTYLDPESADFLNLPIYISQGMKQNLGPGKVQELRTSRPLYEAHQEAHTLLENMWLPSFHHTYQIYKFLCGVPVTNTSVKTNIQNSNVSSGIGVGARLTSQLGKIRGVLKASAVDGSPFHPQHVFQAEEANCTSRVVGADTNSHLPTNRDLTTWRVTVPHVDGGGAQPLYMISVHSVSEDKSWTVLRRDQDFYALRARLSEFHGDKELNDSPLPTRKNPHPSLTANRQRYQDFLQKLLAKPTLRSSELLHTFLTVPNLKPYFTNYSTPDIGVLYQSMAHKLRKEKGQHLDKFMSMFLSSTHAKHDSPDLGVELVGDHNFHETQKKGRDLKKIGPFRNNLNLDPSIQNFPYIVNKLQHTKGACFCMAEAFDSLLDISSTTSRILWVLASTFRQSLDPFINKWFHAMIVKLLSGGRAAIVVKLLHSTIFDNENKGTSPETKAEENYKNAKIGLHNLVPWWSIQIHTKWCKLMDSLLDPIQNASFNKHLAYMLVDQLLINLFPELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERQ7</accession>
    <name>A0A232ERQ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002577">
        <property type="protein sequence ID" value="OXU21012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERQ7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="61" mass="6901" checksum="F013F6BAAF89B230" modified="2017-10-25" version="1">MSIARIEVSKVRFNLRAGELKIVAWVKSCLGLKIVKSGKDGRKELQFEPQIVEINCSDQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERZ9</accession>
    <name>A0A232ERZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002549">
        <property type="protein sequence ID" value="OXU21076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERZ9"/>
    <dbReference type="STRING" id="543379.A0A232ERZ9"/>
    <dbReference type="OrthoDB" id="10268002at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21391">
        <property type="entry name" value="AT04489P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21391:SF0">
        <property type="entry name" value="AT04489P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1176" mass="133982" checksum="17A12628D36783C5" modified="2017-10-25" version="1">MSKSQQQLGQAEIFRAQIVYREWGRRFTVLQQYLKGIHYYEKSSEYGDENFLWTLLGLSEALKKSGRFAEAAVVAEKCTRIDPAHLGANWTRMEALFDVAEFCGSLVCAHQGARRRQSHFRAAVLLANETIEDCVGENVPGDTLRQLQPWIRRLTVHREGLIVERRDDLEDEFQGIDEEQSRFRVDDPPARLRRYRNRMDRLMAGLYLGSTARDKEFLEQLLSSPAVASANKSGSARLVELARDCLVRLNSQQEALRTRRPLYAVRARAEAALSEGRKMGLEREIEFKRCLVENEAKLVLRRLHEARLRRDYSAFFKLFPEQQRYLNALYRMRLALTNQPLEILWIFHELCKLFLEIRRYDLARFYAKKTRDLSLESNHEDWALNASHVLIRIELAQHNRNEAKEAAVTALESARKLNVYFLEDFYERAIDYIDGLDFGRLSDDDSIAARRKLISSLMTDDTKPGMDLLLRTMEAVPARRRMSVMPGCKPKNQKLGLPTKRMTVKPGPPKDFDKESREELLKKIARRTPDVIPSDDPKGQEPRIVVEEVEKRLTLQPGGKRHNCRAKAQELHREADRLYFKGDYESALVLYHRAARLCPRESLHSVAARRTEAAISSAANPAERLLHRRAKSETTDQCPEIVARKARDVVDRNEDPDRDVPKILKYLDAHQDFWRLSSPGKSPRLQSRSRTMLRQLNKCVKSTLRDVESAHAAGDSLAVHQLSGELVNLVSLGEESHRSQIRALEYLLKKQMELGRHDRAVDLAAKMIFLARSCRDELSLVEALVTVGKVHLKFGCLDALARVWERLADDLREEPIPSAWLHHDIGRCHLELGNFSRSLHFSKLCLEHAESVKSKKWILRGQLLSGQSLLKLGRLAEAVGSLKTAARIAEEDKGEGEASDQSILLYVQSLIDQVTRLLRRLNRERDGRIELRADEIGRDSSPANSISKANRARRNDETEAVPVIPENLEEEEESTSAEDERISQLLKRTRALRRERRGTTPRSGSDKKVQVPRLTAATLSAAGSEDQHDEDVVADSSRTRVITYGRSRHGWVKINSDEERTLRMGDLVALSSGLSSAGVTDGEEDAWSETTAKEEMPVTYFSPDDDLPTSRSSRPISEPKQSHTDDPVESSTVAETKQALFDTDGLSAYLRSLESCEFLEQEQPYLESRSNPSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESF9</accession>
    <name>A0A232ESF9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002424">
        <property type="protein sequence ID" value="OXU21299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESF9"/>
    <dbReference type="STRING" id="543379.A0A232ESF9"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU21299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="214" mass="23837" checksum="EFAA77464CDD9167" modified="2017-10-25" version="1">MAKSLYKLSRELVGHSGDVRDLPVPSDGSILSASRDKTLTRPREAVMNVIKHWTAVTGDYLRNLYGHTSYICSLSAISGGSLVALSGEDITVRLWSNGEINQTITLLTQTVWSVRILPNEDIICGASDSFVRIFTANPERYADSEILQRFEESIANTELNAKTELGYFKMSYLADQSALQRTGKKDEETKLIKEAGGVKAYSWSQKELKWISSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESI0</accession>
    <name>A0A232ESI0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">DDB1- and CUL4-associated factor 1</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Serine/threonine-protein kinase VPRBP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">TSAR_001940</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">Alberta</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex. Interacts with DDB1; the interaction is direct. Also forms a ternary complex with DDA1 and DDB1. Interacts with NF2 (via FERM domain). Component of the EDVP complex, a E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1. Interacts with DYRK2; the interaction is direct. Interacts with RAG1; the interaction is direct. Interacts with LLGL1 and LLGL2. Interacts with histone H3. Interacts with ESR1 and LATS1; probably recruited by LATS1 to promote ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation. Directly interacts with TET1, TET2 and TET3 (via C-terminus). Interacts with CEP78; promoting DCAF1 localization to centrosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VPRBP/DCAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01002420">
        <property type="protein sequence ID" value="OXU21314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ESI0"/>
    <dbReference type="OrthoDB" id="27563at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000055">
        <property type="entry name" value="DDB1 and CUL4-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129:SF4">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="VPRBP PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0804">Transcription</keyword>
    <keyword evidence="19" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="348"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="965"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1480"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="1483"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="1511"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="1536"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00063313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00071147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00078221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OXU21314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1577" mass="176674" checksum="155840F1BAB1E9DB" modified="2017-10-25" version="1">MCSIVVGVSTGLDLFTVALEMATAESLAEVTDVVQILRQWEEDQNSPTYDPIPTLQRLAEIIEQETENYFKMDPDPFDERHPSRTDPECNFGHILKVLFRKEIFMTKLINDYLRDNYWLRVGITNRDVRGLNTAACRLMLDILPGLETSAVFQPDMEGLIHRLFQWAETSTEPLQSYATGLLAAAMEVQDIATGFREQNGKMVPLMLKRLHELQKEAAEERRQSNATRPFAHLGQNRANNSVADSEHKAFPGKRKVREKSRENGVVKSPPELADYSSSDDEGKEGSSPPNKKLKNKVEDVQGTPVKKDTQDREGCEMMSPPIAIPPLNSGKNNASNAQTTTTPVKNENVTTKNMSTTPLKNQGSAVKTPSSPVWSKMTSNKTPSTLVEGNSNSSWAEMESHVIGNIQIYPPTLATRQMLILRYLTPMGEYQEFLGHVFEQNALELILQYINVRETKDSRLAFEALKYLASLLCHKKFSIEFLSIGGLQRLLDVPRPSVAATGVSICLYYLAYCEDAMEKVCLLPKHIITDLVTYALWLLERSHDSGRCHATMFFGFSFPFKVILDEFDAQDGLRKLFNVISTLPLLNIEEEATLNDDEECASRQIVRHVAVALKKYMEAHLYWKAEQLQRAENARTERDTWQPSLPSYKACKLSPEEVQAKVEVLQELMSLRALWPPVEQLHRLGGVALLLQIIAFAREWNFNSRVHNTSSAETVRACLDVIAICSVVPKVMLLLCERVDMPDLSMTMSINLLLAAAECEIIVDPDVQRAALRAVINCVCAPINRVGGNVARYSVTGSAKKKNIHNSEELIQKVWESVRSNNGIMILLQLMMVKTPITDADSIRALACRALAGLARSEKVRQIISKLPMFTDGQIQALMKDPILQEKRQEHVMFQKYALELMERVSGKAKPTGAEYEISLVSLHRANVVAQTRIQYNEQQLHQLIYQHLLSKGLTETATTLQKEANLESPTPRPAFSPGAAANLYNTRCPPTPRDVVARTNTTPTTNSSRFISHTGAITNSTPTSNNNPVRVKLADTMNQSPVAPNQPIKINQINFKKTERQLSTIQQNLIVSSQNQQACRSLQKQISRDPGGTTLGVASTSVQAVTLDSIITEYLTNQHALCKNPMVTCPQFNLFEPHKCPDPCKKNSTHANFAVRFTRRERGVNGMRFDRRQIYSRFCPVKTFRPLDIDGTFTCCTFSPCQQYLLVGTYAGEVKMFSVRTGSEEATYACHESYVSHVQCNQRGDLLLTSTAWRSPMSALWSMGMFFDMKIPFEHEDYVEFSKLQDRIVGTQAEVATIYDIATGKLIKTLTPSISNQYTKNRATFSMNDELILSDGILWDVNSGKEIHKFDKLNQTLNGVFHPNGTEVVSNTEVWDLRTFHLLKTVPALDQMNVTFSPTNSIIYAFSSEQENEDDSHNITSFKTLDALDYSSIATFDVKRGIYDLACNKFDTQIAVVENMGEFDSIQESCVRLYDVGRRRDDEDEAEEDDDDEDLDASDDDGSNSGSDDNNADDADNGDAQEDDNGDGDDHGDGDNDDDNSDGEDTGDESLDFHAGIFSSDEYGVSDVDDVELLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESQ3</accession>
    <name>A0A232ESQ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002385">
        <property type="protein sequence ID" value="OXU21390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESQ3"/>
    <dbReference type="STRING" id="543379.A0A232ESQ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="4">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU21390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="143" mass="16458" checksum="4B0BBD52E911CDBA" modified="2017-10-25" version="1">MPNIKLQSSDGEVFEVDVDIAKCSVTIKTMLEDLGMDEDEEEVVPLPNVNSAILRKVIQWATYHKDDPPPPEDDENKEKRTDDISSWDADFLKTKDCTLIEHWALTNRCRTWTATPRLGFNLIELSLLEFDDDPVAYNHDYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESY6</accession>
    <name>A0A232ESY6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002358">
        <property type="protein sequence ID" value="OXU21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESY6"/>
    <dbReference type="STRING" id="543379.A0A232ESY6"/>
    <dbReference type="OrthoDB" id="7698353at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="196" mass="21690" checksum="769C855B243270C1" modified="2017-10-25" version="1">MDDLITVSEVETSKDDEMAEKILDHPYYQLIAHTKALEQLFEANPGLDIALDEVLEAVKHFKSQAHGSDGIPQSFINASLPAGFRTGHITQTTLLKLTDEIITGANRKLSTILILFDFSKAFNSVCHVSLLLKLKGYGFATSVIKWMASYRMGRKQAVQDRDNSHSTFRYLNTGVPQGSVLGPLLFALYITTSLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETI2</accession>
    <name>A0A232ETI2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002270">
        <property type="protein sequence ID" value="OXU21669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETI2"/>
    <dbReference type="OrthoDB" id="7697921at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="453" mass="51786" checksum="B869FB8650129D74" modified="2017-10-25" version="1">MNGGMIYNRTCSTCFEIDVKFAMAIRRNQKEWVISDGEDEDEEVGLDVRELFALSKKKAVSAEPLVNNSEDTTDKFHTPNEEFALSQASSQLTLKESDTEKYFTADEDKTPNTRLENSLDAGSISEEEDPDEKIGPKVSQTTNAVVFDDEDNNSDLPATNEKEETVGNDKSENSSALKNLISDKGKEKTKLNEEEETEANIRPKVGQIRSSVRSDYEDENSDVIVIDDEETVVNDKSENSSAQEKSAVIYDDDDDDSDLIVINDEEDVVSNGSKKFTARKNLISDEEEEEEEEEETDKEVSKESDEPVAKKSKIVKPFGTVRGFQKCNDKNWWDQFLESVPDNQKCEIGNCSFAPQPHKKHDVNIRSYSLYETRLIIQYLIYHNVIEYGKGIKVWKDFHSLGYLTHRSIESLNNHFKRYILRDIKSYKLPKDIESKFLKLRTSRQGLKRLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETI8</accession>
    <name>A0A232ETI8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">General vesicular transport factor p115</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002265">
        <property type="protein sequence ID" value="OXU21680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETI8"/>
    <dbReference type="STRING" id="543379.A0A232ETI8"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045056">
        <property type="term" value="P:transcytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000394">
        <property type="entry name" value="general vesicular transport factor p115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041209">
        <property type="entry name" value="P115_Arm_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18770">
        <property type="entry name" value="Arm_vescicular"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="11">
        <location>
            <begin position="356"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="12">
        <location>
            <begin position="688"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="677"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="94286" checksum="26282C28E4AE1B8A" modified="2017-10-25" version="1">MEYFKSGLKSVLGAPTPDNQPSGADTVDRLVNRVQSSTLLDDRRDACRALKALSRTYRIEVGAHGMDALKQVLEMDKTDCEIVGLALDTLCNITSPEAFDEEVEKHGPKHQIGEQFTEILIKNHETVSQILRFLEEFDFRVRWPALKLLSNLLANKPKDIQEIILVSPMGVSKLMDMLSDSREIIRNDVLLLLIHLTKGNTNIQKIVAFENAFDRIYDVIVQEGGVDGGIVVEDCLLLMVNLLRGNYSNQNFFKEGNYIQKLTPIFQLSALPVNASEDNLFLGWSPQKVSNVHCMVQVIRALVAPSGPAQSVSACQAVMNKCGLLQALCDILMISGVPADILTETISAVAEVIRGNPNNQEFLGNVMAPSSPPRPAIVVLLMSMVNEKQPFLLRCAVLYCFQCFLYKNETRQQQLVQTLLPEGNESPTLTTGQLLCGGLFSPDPLSNWFSTVALSHALIDNVNQKEQLLRVLLATNIGTTPVTLMQQCVMLLQQNNKIQSKLGLLMLLCRWTSYSPVAVKTFLSINSSISYLIALLSSHENNDDHQEILLQSMCAFLIAICVHFNDDNVPNYSKVKLCNLIENRIGLEKFQDNIGGITRHEVYSRSLKHPQSSAKDPSEVLLDHEFCRLLKTLEGVVLKSVLDYSSSSNGKEQSLLVSDSEATAPYKEVIRQQDLQIQILNTTVTNLTKEKEILQQQVSELKAEVDSLTDQTKILRAAQISYSEDKIPQTIPNNVASSNEELEKYKNQISGLEKRLSESLTLIQELQSKTVDSKTTTDLENRLKQQTKEFENLKKDQDDLLVLLTDQDNKLIMYKERLIALGEKVDSDESSGEQDTDDQPESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUF5</accession>
    <name>A0A232EUF5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002146">
        <property type="protein sequence ID" value="OXU21937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUF5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="10815" checksum="F8B34D9D80E97468" modified="2017-10-25" version="1">MGGKAQQICAKPKENMIFKVPIKSEHLTLHMHTDFVLFKGNYCVKSVIDAIKFTNDEVCTVLVRLFTLNPMALAQKMQIALYIKIEFISARINLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUV0</accession>
    <name>A0A232EUV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002090">
        <property type="protein sequence ID" value="OXU22107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUV0"/>
    <dbReference type="STRING" id="543379.A0A232EUV0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="99" mass="11484" checksum="62DD387A7841CB1A" modified="2017-10-25" version="1">MAISYATVEGSLGQKLDKMFGVKYSFLRVKPGNCLLPPQYVFIGPRIRDLEIRENDVWLVSYPRTGSHWVQEMAWLIGNDLNFEEARKTHFVLRSPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUV3</accession>
    <name>A0A232EUV3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002087">
        <property type="protein sequence ID" value="OXU22116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUV3"/>
    <dbReference type="STRING" id="543379.A0A232EUV3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08616">
        <property type="entry name" value="PI-PLCXD1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042158">
        <property type="entry name" value="PLCXD1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="40"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="348" mass="40231" checksum="4AB0ABAF52E17B92" modified="2017-10-25" version="1" fragment="single">TIIMAYDDYQGATIDVTDTRDGPPNLVENLEFWMTELPPKLRTIPVVQLAIPGSHNSMTYTIDRSDDVGPDEPELIRSLGRLFATVAKPIIFNWSINQNITIKDQLNGGIRYLDLRVATKQDDDKIYFLHGLYGAEVSQPLQQVVDWLNDHPFEVIIMDFQHLYNFTEADHRNLIDRVKYLFRGKLCPVSVNFDHVTLQWMNSEKYQVILVYRNPLARNFGDLWPTGLWPTPWPDTISRSTLIEFLNEGIRNRSLEKGYVSQCLFTPNATYILKHICRDIRYLSSKCRTVALPWIEEQRPGAGGLNVVITDDVAHDNFNFSKTVIQRNELLLGNSQPYYNEDIKRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVF3</accession>
    <name>A0A232EVF3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_008903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01002003">
        <property type="protein sequence ID" value="OXU22336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVF3"/>
    <dbReference type="STRING" id="543379.A0A232EVF3"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011811900" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="22"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="635" mass="71742" checksum="6D61F3708DC0D71B" modified="2017-10-25" version="1">MRNRKFFLLLVIPWFHCVFGNDPQVETNFGPVRGVWLKTARGANITGFLGIPYAEPPIKELRFENPVPWTEKWTEVRNASSDGSNCLQLRDTGLVGDEDCLYLNVFTPTISQNVNETQQKKLSVIVFIHGGAFNTGSSNSSLYAPTYLLDHEIILVTLNYRLNILANGWCTGFFSTGNSVAPGNYGLKDAAMALAWVHDNIEAFGGDPNSVTLMGQSSGAVMVHLLASSEATKGQFQKMITMSGAPTAKWAVHTRENIRNSSLHVAYLLECAHESDFDDMGSGDGENGTVVEDEDVTVRQEKIERKIMQCMKSTSPADIVMKSYYHMWRRNPKCIYGPTLEADAEGAILTVHPERSLTDGLFRDMPWINGVVDDEGLLKTTDLLLNSAIKDEFLRDFDTLLPSVLELQDSIENITEFSDAIKDFYFDGDILRNIESNITQAISLYMVGDALITFSSYDFLQRRLPQMKSKVYFYVLAYEGTFSTTFRWGIPFRFGAAHGDDLNYIFPYLNEKYADLQLFNTMGDRTMINIMSEMWINFAKTGVPSARLTSSWEPFQEHGRFMRFGDGRSTDRDMEQDFLTERMDFWRDLMGNYSLPILEYRAGQPVEEDVVAAAAGIGFTRITLCLALLSRWFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVI1</accession>
    <name>A0A232EVI1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_012016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001991">
        <property type="protein sequence ID" value="OXU22366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVI1"/>
    <dbReference type="STRING" id="543379.A0A232EVI1"/>
    <dbReference type="OrthoDB" id="10062424at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF4">
        <property type="entry name" value="DUSKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012285611" description="ZP domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="218"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU22366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="705" mass="77511" checksum="6F21FC6274C080EA" modified="2017-10-25" version="1">MRLGALVLTCLLFQGKIGGLMDRPENRTFDGFQQISVRNSKRPSSYVEQVARADQVDVVEAIPGDDRNQENGQDADQQQQQQQQQQQQQQQQQQQQQSTADVLAAALDALVGDSESSGGSNGNGGQYGSSNLRVHPGRGSVGMPPPRTHHNVAYHGPPPPPPPSSASSPGSSKQQLQRVQDSIDKVFDTAIAASTNLDNENWPTPGNDMPKIVSLDVKCEKNSMKVYLGFDKPFYGIVFSKGHYSNVNCVHLPAGLGRTSVNFEIGIHACGTNGNTDNGLYGYGESGSGTYFENIVVIQYDPQVQEVWDQARKLRCTWHDLYEKSVTFRPFPVDMLDVVRADFAGDNVGCWMQIQVGKGPWASEVSGLVKIGQTMTMVLAIKDDDSKFDMLVRNCMAHDGKRAPIQLVDQRGCITRPKLMSRFTKIKNFGASASVLSYAHFQAFKFPDSMEVHFQCTIQICRYQCPDQCSDSPPLLHGDGLLIENHRASIGHADVSAYNIPPPPVHLPIDAYLQSVGRPRDERRRKTRAIPASPGKSKSEKNVGVNRVIRVVSTGDLTFSLDEAANSSTSEDTSTMVFPVREAHTANANLICMTTSGFTLTLLLLLGILIGSCGLSAYLFIRLRPFRKRIDESAVHVRGFPVHAIGKPAAPKSACFYSTNPCTSSFSQLEVFLTCIKELEEFTLAFDKEYILVLDMRIGSTNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVI5</accession>
    <name>A0A232EVI5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01001993">
        <property type="protein sequence ID" value="OXU22363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVI5"/>
    <dbReference type="STRING" id="543379.A0A232EVI5"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF169">
        <property type="entry name" value="GH15759P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="358" mass="39868" checksum="A387D1B1BD7C9FA5" modified="2017-10-25" version="1">MLPGFLAPLLCRLFIFYKGESPVNFSVFPVGQCLFCCPVNLDRDIQYQLYTRRNPTIPQTIQPNNPCSLRRSNFNGSQPTVLYIHGYSERSPGISGASIKNAYLFRNNFNVILVDWSKLAPMPWYHKAVGNTRIVGPHVASTLRWLESIGAFNLRAVHVVGFSLGAEVAGFMGKALFPQRVGRITGLDAAYPLYMNTGAEGHLTAADAEFVDIIHTDGGVLGFPIPLGHADFYPNGGMPPQPGCNVENVFAMGVNKIVNRFSKSSPRILRFRPQSHRLALFPVTCSHNRAWRLYAESITDPAGFPASRCPKWRADLRVNCQWSPDALMGYAATRRLRGMYYLRTNANSPFARNITGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXB4</accession>
    <name>A0A232EXB4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_001276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001774">
        <property type="protein sequence ID" value="OXU22957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXB4"/>
    <dbReference type="STRING" id="543379.A0A232EXB4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU22957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="496" mass="56525" checksum="2DF0BEFA406E36EF" modified="2017-10-25" version="1">MSAENAQPLDKTTYMHEEYTLLQDLEEYQEDILGGLSVLVNDNNLDNTQVQQLVLNDELLKTLTAVTLPDGTQAFVAENPSPNELETEEPALRLENGAIFLRDASELNNGKVIQLQLDSLGSECPKNSIGESSDGEVTYPQLQVIDGVLYVVTNQIEESQDVWEVSEETPKLDTIFSTNNQNEEEKPKSKHECPREDCTKVYSTVRHLKVHERTHTGQRPYLCTHPKCKKSFSTGYSLKAHLRTHTGEKPYKCTTEECDKSFKTSGDLLKHVRTHTGERPFVCPFEGCGRSFTTSNIRKVHIRTHTGERPFKCPQPKCGKAFASSTNYKNHIRIHSGEKPYVCSINNCGRRFTEYSSLYKHHIVHTQEKPFECEVCHRQYRQQSTLLMHKKTAHSIIDTDNENDNDDHDEVLDVLLENSVDMIDQANELAYVETGQVEVTDCVPEDETQILLVEDPSQLVTLQAMESLTEEPEDIPIDIALEEFNIKYEDVAFRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXJ1</accession>
    <name>A0A232EXJ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001711">
        <property type="protein sequence ID" value="OXU23156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXJ1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8502" checksum="7007B70D904E20C9" modified="2017-10-25" version="1" fragment="single">MTKMSVSEHWTALGPLDGSSSEAATAVALQAEAHFHHWLFRSTSSSSSSSPSRLHLLVVIRCRRPKLRLAKMRSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXM4</accession>
    <name>A0A232EXM4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001725">
        <property type="protein sequence ID" value="OXU23111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXM4"/>
    <dbReference type="OrthoDB" id="7526471at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="10574" checksum="51CFC6CC9A080789" modified="2017-10-25" version="1" fragment="single">SVFILCLQADVFLLGPVDKRLQSVRHRGKVVLPRVRLVQVPPRVPACNPGWYTSHRSGEFHRVDLVEHDERCPLRGQPAASSSDLHAHLPPAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXN0</accession>
    <name>A0A232EXN0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001742">
        <property type="protein sequence ID" value="OXU23057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXN0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9433" checksum="72598011920DD6BD" modified="2017-10-25" version="1" fragment="single">HAPHVKLFSVVRSATDAQCTQHDLDPLVCWSVRNGLSLNLSKCFVISFSGRRRPLLYDYTMGSASLQRAWPGLQRNAVLLIFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXN2</accession>
    <name>A0A232EXN2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001692">
        <property type="protein sequence ID" value="OXU23206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXN2"/>
    <dbReference type="STRING" id="543379.A0A232EXN2"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="7">
        <location>
            <begin position="777"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="887"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1143"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1166" mass="130567" checksum="46A898FF82A7C02D" modified="2017-10-25" version="1" fragment="single">RCLLRLRTTWLKLHLHKRTIGVAGQSFSLAASLFSIDVGHSVSQQRGSYRAPNSPLHLSNRAHALLLLNRPQASLADADHAVRVRPDWGKGHYQRGLALSALMRNEEALLALCTSAVIDKNPQAVRHELTRVLHRVLAVNVRRQSGASFRTPYDLVEVRMRRNRHHLLLPLISSGHRNHRRSPNGGGGGNALNTSDCEDNSSGGEEEFSQSFCRRLLSSTTPQDNLKLYATLDRLYQEVEKLKRVEAKPAEILLPPPNGGAAGGDLDCILCCRLLYKPVTTPCGHTYCWMCLDRCLDYSSACPLCVTSLADYLASSQKTVTEFVERALKIAAPKEYAARAASHRHELVQNDAAEETAANESERIAVFVCTTAFPCVACPLFVYEPRYRLMVRRCLDSGVRQFGIAACLNREATGAKRYAEYGTMLEIRDRVLLKDGCSILSTVGARRFRVLSGGERDGYDTAQVEFLRDTPIPADQLLNVAELHNKVRAKSRRWWVTVPASQRSEIRRVFGEMPEPEDDWLRLPDGPSWTWWLLAILPLGPQLQVGILGTTSLEKRLRAIEKTLDHMEQRHLSVGPAASEETTQSSSICRDASGRGTMMDDEEAGSRTSGSARTAAVSVVQHTKPAKLAILIESNRLCIASVSVSAKSSSAYERIKSRTTKFLRYSCTFIHLIEYLEPTETRDIISNMQSIMNGNATYFEKYVVAPCPSRDYYGVKVFQNIVTLCLWKVSYGPHLSPVIREIKFSDFNEDKLLKDEIGHIFGPAVLGYLEQVTSKGVNTLLTLPRVVIEKLVRYLDLTDISKLLCTSRISSEIFNTNSIWEILYKSSKEIPELSEMEKDLGASRGFLKLTKDHHLCNVSKKNLKEIDEKLLYAKKMERNDTILRSASVSIPKTTMRRNDDKSSSNKKYSIESNSKQVRKSLKSSIKDFSKSKRLDLPAQPPIFIDRRNFSEKQGADEGYQNTKFIDQAVAEAKIERKDNELAKFQFVNEDDDKTELVLQKNYLKSAIVHSNLSDIDLQDATNKKYGVPKSHRSILTKQSCYNEERDKTPEPRTSKSSKKKLSKAGGASNLKTLTSSAKKTDDLEESGMSYLMKKYLAASDEVARKFSECESLAQSTKNSGIQVDMKEKSERKLLKCAAPAAKQAQSRSGCDGANISTKLQRSLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXY4</accession>
    <name>A0A232EXY4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001720">
        <property type="protein sequence ID" value="OXU23130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXY4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375836" evidence="5">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="244" mass="27800" checksum="2BA0FD6BB9947AF9" modified="2017-10-25" version="1">MLQHALFIALALLTLSEAADLNLSGEKFDYFLLAQSCPQTSCWDLTENWQNSGSSCTSCNKLSDSWTIHGLWTNRYNGNHPFNCDDETRFRPNSVNEALKHEMSLKWRTYKSGFTNQRFWSYEWKKHGTCAAEVPETNSIKKYVSKALNLLDTYNMKTLLQKANIQPGGSYEYNTVFNAFRNVLGVEGRLGCAKNPKNGEQYLFEAYICLDKSFRPINCVSYAGLPGCKHNKKVVYPIALKSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYD7</accession>
    <name>A0A232EYD7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_013636</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001607">
        <property type="protein sequence ID" value="OXU23442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYD7"/>
    <dbReference type="STRING" id="543379.A0A232EYD7"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004994">
        <property type="term" value="F:somatostatin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15094">
        <property type="entry name" value="7tmA_AstC_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000231">
        <property type="entry name" value="Allatostatin C receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000586">
        <property type="entry name" value="Somatstn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00246">
        <property type="entry name" value="SOMATOSTATNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="52"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU23442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="424" mass="47766" checksum="CECDBA8D23535DD6" modified="2017-10-25" version="1">MMSNISRGLFDFADNASQQNITMPLDCDANMPIISLLHQILYSIICIVGLLGNTLVIYVVLRFSKMQTVTNTYIVNLAIADECFLVGIPFLVTTMSLGVWTFGKFMCKAYMTSTSINQFTSSIFLFIMSADRYIAVCHPISSPKLRTPFISKIVSLTAWVTSAIFMIPVFLYANTMETKDGQMSCNIYWPDDHGGQTTFTLYSFVLGFAIPLTLIFIFYFLVIRKLQTVGPKNKSKEKKRSHRKVTRLVLTVITVYIICWFPYWLTQMALIYTEPNQCQSRITITTFLLAGFLSYSNSAMNPILYAFLSDNFKKSFLKACTCAAGKDVNATLHIENSVFPRRNKANAERIQSNKMLTSGNSKNDGEDEENERGLLISKTSTTTVTMTSRSNITVTSEVRDPTSQQQREKDALKNGTQLTLLTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYW0</accession>
    <name>A0A232EYW0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001637">
        <property type="protein sequence ID" value="OXU23358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYW0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="11506" checksum="5AB1B89027BE785F" modified="2017-10-25" version="1">MHAWHADTFEEEIPSQGYATTTWNLRSIRLFIKERASLYFFFGRSRDLRNVCKRLREHKKKKKSNTRVSQFVGFLSIRKIYKDDFIHKRIKGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZB1</accession>
    <name>A0A232EZB1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001501">
        <property type="protein sequence ID" value="OXU23782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZB1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="49" mass="5330" checksum="3E22771CD5E1A704" modified="2017-10-25" version="1">MTNDTIELLARGEGLLTMELLLASAAFKDGICCYFARSSIFEACVLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F064</accession>
    <name>A0A232F064_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001458">
        <property type="protein sequence ID" value="OXU23907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F064"/>
    <dbReference type="STRING" id="543379.A0A232F064"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="273" mass="31015" checksum="0F66E67B5EEBBE95" modified="2017-10-25" version="1">MADTKAKTAAPKAAAPKDAASAKKGEKKRVSRPRNYNLGNGVYRFSRSRMYHKKAIYKFIGKKTPKKEVPKKLVSIEKKINGEKNGGTRTVLLKKRKANYPTSDPIVPHPTKKCFKDHTRYVRPSLKPGTVLILLAGPHKGKRVVLLKALKSGLLLVTGPFLINACPMRRINQIYVIATSTRINLSGFKLPKHINDDYFKRKHEKRAKKEEGDIFAKKKEEYKPSEQRKVDQKVIDKAVIDAIKKSADKKVLFAYLASMFGLRSSQYPHRMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0P0</accession>
    <name>A0A232F0P0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001351">
        <property type="protein sequence ID" value="OXU24275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0P0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7175" checksum="FAA62ACBAD7C8883" modified="2017-10-25" version="1">MRAFITLKKLQNIVVGTILAQKCVKYFWLDEIDHLLFILAEARGSDKKGTLKYLFFQDPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1D1</accession>
    <name>A0A232F1D1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001278">
        <property type="protein sequence ID" value="OXU24515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1D1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009420">
        <property type="entry name" value="FlhE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06366">
        <property type="entry name" value="FlhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013099251" evidence="1">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="15211" checksum="E845A04D861C9E88" modified="2017-10-25" version="1">MRCITLWILCVLAAIQYNAVAAHPGSYALDVPYVRGSSGDFFVQANFPKPTIIGGPATINSVRWRYDYRDNWVGLQAYICWRNDNNCLDISNQASGFSEAFRGRDASEPFKMLFRHRSGRTGDIYSCQIIVNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F281</accession>
    <name>A0A232F281_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_008040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001277">
        <property type="protein sequence ID" value="OXU24517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F281"/>
    <dbReference type="STRING" id="543379.A0A232F281"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF19">
        <property type="entry name" value="FI01119P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU24517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51258" checksum="8FBF395A6EE14AF0" modified="2017-10-25" version="1">MDSKGGMKTYVRRRKGDSPSNVIIHLNELCRLCLAKEEEMVPIYDEDAVPLPLRIMACVNLEVYEEDGLPNMICHPCKYQLEKSYQFKKKCEAADAKLRKHVKLIQQLSGQEDDDTRSQDSRSESEHTQSSGKSRRVKQLLADLVSSKPDASNSQAEGDPIEVTEEELVGGYILGMGAENADLEDNLSEDPENITLVPAEERSAKARCTIRGTRIKQEQESDEEADEIQRTIVNSDGQKMYVMEIQSPQQSQPQMQQTVHPPIVESGEELKVFQCDKCPKAFTRRIMLKSHQSVHSTQRGFTCQACEKWFPTRSALVRHERTHTGEKPFGCNICHRAFAQKEILLRHLMTHSGQKPFQCQHCEKSFTQREALKVHMRRHQKLNPNDIQLHHCQLCPKAFCHASGLSRHLVTHTGRTYKCVECDKSFTDKSSLLRHSRIHAPKPMMTNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F297</accession>
    <name>A0A232F297_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_000685</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001255">
        <property type="protein sequence ID" value="OXU24598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F297"/>
    <dbReference type="STRING" id="543379.A0A232F297"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU24598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55187" checksum="A0FC182480DF0C79" modified="2017-10-25" version="1">MLALYGLLAVTFVLLIVYLGPSKKRLPPGPRGLPIIGNLLSIDPKTPHESLAKIAWEYGPVCGLHMGSVYTVLLSDPKLVRQLFAKDTFSGRAPLYLTHGIMKGYGLIASEGELWRDQRKFVSACLKNFGMVKFPSPKRDQLEKKILVAVDEAAEKLEARSRGAEGLDPHSTLHHCIGNLINGIVFGKVYDEDDELWKWLQHMQEEGVKHIGVSGPLNFLPFLRFLPRYGNTIQLIVDGQIKTHQHYRKILEDHRKCPTETNSFLATYDEEMKRRVANGEPLASFTETQCFYLLADLYGAGVDTTLTTLRWFLLFMAAFPDEQAKIQEEISNVVGEKEPNLEDRPSMPRLEAAIMEVQRLRSVVPIGIPHGTTEDTHIGDYDVPKGSMIVPFQWAIHLNPLYWSDPRAFKPQRFIAEDGGLAKPAAFLPFQNGKRMCVGDELARMILILFAARILHRLKLSAPPGQTVDLEGDCGITLVPKPQTLLFKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2J3</accession>
    <name>A0A232F2J3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_006151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001240">
        <property type="protein sequence ID" value="OXU24637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2J3"/>
    <dbReference type="OrthoDB" id="6351660at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097711">
        <property type="term" value="P:ciliary basal body-plasma membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905349">
        <property type="term" value="P:ciliary transition zone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026201">
        <property type="entry name" value="Cep290"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879:SF20">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="913"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="990"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="491"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="667"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="752"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1331"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1461"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="842"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1626" mass="187292" checksum="A89F2341E96CAEFE" modified="2017-10-25" version="1">MKSSCKTRLMKDTSKRATKGEREMNKKMQDASKRISTLESLLERAERDAKVKSEQLCEALAILNKYEDENTSLTNALEEIKELKDQLEKKNKYVEDLVDVVNRLESENSRYEDAIIVLREKLGITEDEEFAIEDLILRRQQAQEEKIEEIQRSCDQQASENVDLKFQIRKLKTALKESLKNKLRRTNGISSDGENIEDLSHRSESKKDHVELKKMRENVKWVIEENEALRQGMHEILDCIHHQDGKSIITIQSQTLENLLEALDARHLAGWYHPAMRLQGRVNYLQGSNAELRAQLQQIRKNQMMILEADSQQRSSSVEEGECSQQQTSASSKTDLQPALSQSRNVTPKSSENADSGRASGKPADMDEIQRVDDDDDDDDDDEPSGSCDTPLDDEGFGKKSEEVYAMAKEIIAQESDFKKALNEAETRQKILEAQVVGLRKNLASYVSPEAHAELRERYLEANMQLRAAFESKKFGTNDEDSVEALRSKAVQELRNELVSLHKQLSELALSSARSNTTDGRAVGELEGRLAELKAENERLKKAAEIAHQEALIHRAIDSTVLTEFNDLRQRILKFELDEDTGVKETARLSFELANHKVIVTELREQKKLLERDLLKAREELADLSGGRESEGQVVELVSRPTDGRDYIEIIDFLQHQYAGSTSLSAWERYEASLNKLNNDRNEVKELISQINDQNENLKIQHETLTSRLQIVEQLKDMLEQQIGSNDVQDIMQRFTIETRQLLSESKYKALISQLEEEGKKANSKLSDYEKKVASMERELRNAQKAWKVQKAESLRRPASFDKATEAAFKSEKEAKSAQTELKVHSVETQCSLCCKTAMRDSQVEKNESEVDNKTRESNGEGPLKTTKINLLQEQLNQALALASERSVALSKCEAQLTEYLARNDSLSRLLEEKTSSAPVTTDHEEDEQLAEKSGHTSQEALQSSVKSLQKIISQKEETIARYQSLLKEDRDKHSEAAARLQEEISSLRKSLADGSNKDNAMASPNTEQPERDIPTGETTPASASRTEETSILREKISRLETELSISAELAERWHRLAEDRLRHMDSTRERLEEQHREEIDSYRMELNKRQREVVELRRQLSENRRAPTTKSEVLSFMKVLQIKDNRLADAIESELEEHAAAVTSQQLSTTYEVEDARLYEFEQMQSQLDNLRRQLQASMERERSYKNEIAELQQRMSRRYMAVKAQEKKASKREMQLERKVKELEGELSEAKEMLDRHFMAQQAKRAKTAEDLGLWEKLKKWQQTAERLKEKLKEKTDECQRLQSNYEKLRALISCMEREKWFLRGKCRSESVAVSAWMPPPAESHCTSSSNNDLLVEELQRECRELRERVKELVGRLSRQEEEKRRAASVAFEDEVYTDEEIKRLREVQEILEKENIRLEAENFELRLELERANVNTPRYQEKIQHLEKYVEILKTEKSSELSYPCSAPLRRDGTQRTKAELERTVVTLKKLVEKLQQENKRLRTSVAQSDLDLPAQCNCVYLREDYEQAKQRIAVLESELALAEKRIAMMEETAALKSDDDNSEEVTLLRQQLHRKSELLMKVKDLLSKAASNEKELRHRVSTFRVDNEYLKETVVLLSYIQQLEFKQTLSIIPECGSSLAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Y8</accession>
    <name>A0A232F2Y8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001085">
        <property type="protein sequence ID" value="OXU25196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2Y8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7322" checksum="20CB53CFA9A98ADF" modified="2017-10-25" version="1">MENHQPLNDLSWSLPLNMYLAPHLFGLSAILVLPMLPRTREAGGSKAKHEKASAAASHSNGHVHKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3S6</accession>
    <name>A0A232F3S6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein inscuteable homologue C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001033">
        <property type="protein sequence ID" value="OXU25411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3S6"/>
    <dbReference type="STRING" id="543379.A0A232F3S6"/>
    <dbReference type="OrthoDB" id="5796379at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="2">
        <location>
            <begin position="418"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="735" mass="81210" checksum="8EA5E2D4C70DABA6" modified="2017-10-25" version="1">MSNFKRFQSKVFWNQMETRDAGNFDFPSPVLLTSPRRDPTIFVAPASPMIPRTDERDRVDGVPESDTSVDQENVTVIHVEMCGSPAVREEPSNEAVAVEDHLLAERSFSPTSRGQRSQDSGFSDSGRSDSSGTSNKSPRRRRKRRSSRRRTHPRIAGLREAENAEDDGPAHTSTPKQETRQGCRLKKPEMKELSRQLDFSDHRNNEEEPVLARSPSIASRETINDFLYTSEPPDYCEQLSSIPEDSYPRLPQSCSRVIPSQGLDVRAPVRCWLEEIRYDEEDEMDILFSKRLPRRKLKDEEAESRDLRLLTASAATAAKKVIDAADSFEKRYQRVFDSIGNSKSNRSERDALRKIEAEASEILLKMGSTMPRRTDQRENPKNLAMQLGRLKNSVDRAFDKRLDFYIEKVVLALEEAPSEAGSAARGALAALTALGLAGPRAGASVARCSGIRALLTSLVSAGRLSSELRSASLRALASVCCCIEAVDQFVREGGPEILGDILAADSTPQSEKSEAAALVVQITAPWMDYVGLPYVEPFAHDLISALTNLAERTSCKQTLLLSTAAINHMAHSRRCIGPIIKCDSIKRLLRCVKKTSSGNVWLMEQVASLVGQVARVPQARAHLAETRASVALVCFLRMQPPGLEAESYRRLEATATEALTRLCVDPEIAKQVVAVGGSDCLPSSECSGQACVGDNTRRAEAASNHKFHSTKSLRVARKIAAEQIDMARMWDSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F472</accession>
    <name>A0A232F472_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001068">
        <property type="protein sequence ID" value="OXU25260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F472"/>
    <dbReference type="STRING" id="543379.A0A232F472"/>
    <dbReference type="OrthoDB" id="10266736at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000060">
        <property type="term" value="P:positive regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008530">
        <property type="entry name" value="CCDC22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048348">
        <property type="entry name" value="CCDC22_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048349">
        <property type="entry name" value="CCDC22_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668">
        <property type="entry name" value="JM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05667">
        <property type="entry name" value="CCDC22_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21674">
        <property type="entry name" value="CCDC22_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC22 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC22 coiled-coil" evidence="4">
        <location>
            <begin position="270"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="525"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="584" mass="66795" checksum="0075DE26789A7612" modified="2017-10-25" version="1">MEEVDNIIVHSLRQIGCDVDENITNLASFDTELVVRATVKCLEIIRPGLGLNPVLPVNMAARFRMGATLAQCCSELGYRGDIGYQTFLYSAESDLRRVLMFLIEKLPKESDKSIAEPDTKSAQLEKLISSALQSQIAVPWLPYYCHKKRSKFNIKTKIPFQVVPLNVVVKDDDEEYQNYHLHYKPSLLEQVSNVKYLVPSVIVLNSRTESSPQLTVVEKVNWLNSQEYDRTLEVAENGSGLLGRLITGMKFKDTENQIGDSNKTAQPDIEKQELVEMKEDVNIIKEQEIDRIKTDCEGLKVAIEDIQADIKQLVSEINRATVAEQSEIKALASYEEESKIKMKAYELLENGEDDTQKLKEAVEAYVNKLINLANQWEKHRSPLIGQYRDEREKHSSKASASQKKLDELRLLRDKERELLEECRSKDQQYSQLVADVQKLPREVNRSAYTQRILEIINNIRKQKDEIDKVLGDTREIQKEINTLTGRLERSFTVVDELIFRDARTKEVSRKAYKLLATLHSDCSELVNLVEETGATIREIRDLEEEIDSESTKNIGANLERITADLKQMRQETASLTAQLQSKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4Q1</accession>
    <name>A0A232F4Q1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001025">
        <property type="protein sequence ID" value="OXU25443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4Q1"/>
    <dbReference type="SMR" id="A0A232F4Q1"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF13">
        <property type="entry name" value="LETM1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="175"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="360" mass="42147" checksum="6C9CB4E51B236A24" modified="2017-10-25" version="1">MFRISTRLLCRRNLTLSSPTSSTTFQKRHTAEDDKPNLSGPNSKNSRVTVLKKYWIFRYVDYVKNYEKILEKNFPKTMHVYRVFSIGSKEFYADLKRYMQVRKKIRNFGADTLNREELQLTFTFPKDLIKISPVLLISAVPFTNYIIFPLAFYFPHVLLTSHYWSIEDKLNFMLKEHKKRLQHNKPLLRCVQSQVKTIQDTESRATFKNIIACLGSGTHPTIDDILYCKKLFSGPPYSLKCMKRKHVKELLKVHGMSRFSLGNRTRLLERGLLIKRMDTAIQREGGVTKLPYDAIRWALSFRGVNPVNMSTESMQAWLDQWLLISSQVDEGSISLLLHCPILLAYNHETNWTLLYHDKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4W3</accession>
    <name>A0A232F4W3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000976">
        <property type="protein sequence ID" value="OXU25652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4W3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="15052" checksum="E4CA25E144E7D02D" modified="2017-10-25" version="1" fragment="single">HEKKKFFVQKINNHENNFFSYGHQSYHFIRHPKILAKDSYLDYSYKSATEYVIQVSFKAPNTPTYAKTSQLTRTPIRRCANKYPSRYITDRQSQNPAEKQLIKIIRSQTISLLHHRPKRSQKQKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F500</accession>
    <name>A0A232F500_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000998">
        <property type="protein sequence ID" value="OXU25558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F500"/>
    <dbReference type="STRING" id="543379.A0A232F500"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030834">
        <property type="term" value="P:regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000097">
        <property type="entry name" value="WD repeat domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="605" mass="66402" checksum="BB4BAF291E190DD0" modified="2017-10-25" version="1">MFLSGLLPKYIFATLPRTQRGQPLVLGGDPKGKNFLYTNGNSVIIRNIDNPAISDIYTEHSCPVNVAKYSPSGFYIASGDQSGKVRIWDTVNKEHILKNEFHPIGGPIKDIAWSPDNQRMVVVGEGRERFGHVFMSETGTSVGEISGQSKPINSCDFRPSRPFRLITGSEDNTIAVFEGPPFKFKMTKQDHTRFVQAVRYSPTGHLFASAGFDGKVYLYDGTSSELVGEVGSPAHQGGVYGVAWKPDGTQLLTASGDKTCKLWDVETRTLVDEFIMGNTVDDQQVSCLWQGNHVLSVSLSGFINYLDLNNPLKPLRVVKGHNKPITVLTTSQDKSTIYTGSHDGYVTNWKSATGENDRVQGQGHGNQINGMKASADIVYTAGIDDTLRTIDIATNSYENTSVLRLGSQPRGLDIYGDIVIVAAVKQLVVTKEGKKVSGLPINYDPSCVTINQENGDVAVGSSSDNKVYIYSLDGTNFTPKTELEHLGPVTDASYSPDNKYLVACDANRKVVLYVVPEYKLAHNKEWGFHNARVNTVAWNPESSMVASGSLDTTIIIWSVTNPAKHTIIKNAHSQSQITQLVWLDEETVISVGQDCNTKIWRVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F554</accession>
    <name>A0A232F554_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_007968</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000942">
        <property type="protein sequence ID" value="OXU25805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F554"/>
    <dbReference type="STRING" id="543379.A0A232F554"/>
    <dbReference type="OrthoDB" id="8182981at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012918041" description="Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein" evidence="13">
        <location>
            <begin position="22"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="14">
        <location>
            <begin position="222"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU25805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="642" mass="74104" checksum="A250B446F8F7EEE7" modified="2017-10-25" version="1">MDLRACLVLVTQFWWGSLTLGKRYDILQKNEISWISEENLTVVVEYSFPESRCCIVHVRKNATRAEQTMLKWFSTNYRGQEYFTRRKTYVCADHLLISSNSSELTNSLRSIPVAKASTRILVLIDSRLEESSSLFNASIYVNSNVNLLCRNGTYALSENYLEPRRFKKISRFKELQRKTGIADFQGRVIQASTYYSPPFSFLKSTVNKTIRGVSAAIFVPVKEKEIDGIELNIFMIIAKTLNFTYTIRKPIGRYNHGRKYNDTAWIGGMVGQIVGKEVDLAFSNIWINLDNSQFVNLTKPWTQVFLHFLVPRPKAFTSFWALTRPLSPTVWFVILGALALKTIYIYAKAKINPLVPKRFRNVVVTFTELLGRMLGTWLPPIPPQIRLQFILWELAGFLIVTIYCSSLAARLTNPEFEQRIDTVRQFIEKNLTWGRESTAPHFKEYFDLSVEANLFAKDKWAKQMPSRFILERSSEDRMNRIFQGNYGVIGRIVGDVYYPENSVTNEALEVLRVMRNPVGQFYTGFAVQPWLLDPVNTVMMRLKESGIILYQMVHVVHRRTGTHLREVFIEHDSIDFNKFIDLAINPLGVGFAMLIFGLLLATVVFYSEIRAVQGKATFVETLRGIRRRQLSETYVTLRNESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5S9</accession>
    <name>A0A232F5S9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-hexosaminidase bacterial type N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000936">
        <property type="protein sequence ID" value="OXU25840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5S9"/>
    <dbReference type="STRING" id="543379.A0A232F5S9"/>
    <dbReference type="OrthoDB" id="5806726at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="6">
        <location>
            <begin position="422"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="984" mass="108597" checksum="2B7EB4213548E2AE" modified="2017-10-25" version="1">MHTRGRRRETALAAAELCVLHRGGGEGPPSAHGRGAWKMQEICENLRRAVEHGRTDIVRSILEACEDNEVGDGITKDKILNGAIFEEGTPLLYAAAHNQVDLIRTLLNCGADPAATDIQGRNALDVAVNDRVRQIYIEELLRATAASEIDRVEQILLAGIDVNAWDSEASRNTPLHWAACYSNKEIVQFLTDKGANVNAENGCGATPLHEAVNRGEIEICQILLRNGANPLVQAVKGTFAGKSAYDLSRNNSLLQCLIEKFIGDMPSKEGENAHSPLEVLEDTNFSPKNIVETHQPLSADSIKSLENSFEVLTSIGDSRESGTDSPLRTRRSVANSGIYELIWPEPKSIIELGHVSPPFAVGKELLISIIQGGESIHKILDVWEISRTHLLELGCDVKIGEVQPGSGRVTCDKRIECIVNPKLFNVAEGYQLHISQNSIKVSAGSLAGLHYAVCTFVQILRLSKNRSSNAEICEIEAVLIKDEPRFGHRGILLDISLRGRAPTLDYLLHAIDVWSSFKLSHLHLYSRLTPSCDWQLCYSRSEMVTLDRYCRDRHLELVPALDVDSNVSLRHLSQMWPLFQELLATFPSLNYVHIGPRLASLLVQPSNLDCSLSVDETIETDMSEVLESYSSLQQLWHILNLSFDTTVLLCSNGLHTKAEFRSIPNNVILVEYGFQADYEFSGWTEAFRVAGANVLPSSGTASYNSLAGCPASTYANTKNAVKTAQEQDSIGIIVAHWSGSHHLTSHTFAWVGYLIAAGLSWNPCTNIDVEPSIDFYDIRESSGITNKKSIARLLDTHVFRDLEYKIGSAILELGRVDTLVLTLSKNQGINDLQQIPDNRGSTLYRLLTDPDNVNLEFLSTDLFMKATKQIKRVSHALYEANPTSKFASMEIQELQLTADLMLTACKIGRTLIGVGINPNSNMGLAVINLGVSNLPPTFRTDIANKMLAHIEQYKGAWLQRHLPQGLQSSLLILTSALHRFVPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F643</accession>
    <name>A0A232F643_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000937">
        <property type="protein sequence ID" value="OXU25827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F643"/>
    <dbReference type="STRING" id="543379.A0A232F643"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62333" checksum="79887B1F059412DF" modified="2017-10-25" version="1">MQQVDERLSDVYVYKDVVVIGNGPSGICLSYLLAGNWPHYTGADHPGDEMLTARLRYSVATQTPSNNANDSPESSCPACKLQKRSSGPREKRQSDDPNHCFARFSKPENLETLAIGLEGRNSGKPLSLLMDQLQHPCLDAGLDLPSLLDWKSPEEHEEHKVVDHVVLGKGPPGGAWHTLDPNVLTISLNRWMSLPGLDLRDWESNLSSQERKQKLPYFSEKTGNGTKSTRVPIGTVAAYYKDYVLKQGLEKYFRCGTVVTSVKPIPGVPNSAKEYGWLVQGYESETDQPFEYRCKRVVLATGTTDSSNRLGVSGEETYNWVTHDFKDFERKLDRFNSPLRTSLQINDQYDSKDLKSGIEPILIIGSGLSAADAIMAARLRGISVIHVFRNNPNKPDRKKSLDKLQWLPASIYPEYHKVYEMMGDRGRHYPLYKSLPDHVVVDFRVGADKYTRTKTRMVTLCTPQGRLVSYRVSFAAVFIGSKPDLSYLQNSGIGLGKTPDKPIDSRSNQIDVDVLTYQVKRAPRKGLYAVGPLAGDNFVRFILGGAFGIFANILNEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6A9</accession>
    <name>A0A232F6A9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000809">
        <property type="protein sequence ID" value="OXU26396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6A9"/>
    <dbReference type="STRING" id="543379.A0A232F6A9"/>
    <dbReference type="OrthoDB" id="27680at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="429"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="661" mass="74734" checksum="60CC93D9CD3ABB2B" modified="2017-10-25" version="1">MERSHASNFSGAGSNPHECWEVYQKVLEETKTLDDYLDEECSPRSFDEGEEEAEWLRAAGLGELTEPWKEGREIQPEELGAALRPLSRAQAEAVKRRVRSLNHTVKQRYNQRQRVRKPDIRDVFKDAEVSSTGTRSRSATPDSLDSVSGETPESASPPSPPTVTVITPHHGNSHVPSFVSMFHRNSHENKEGIRRLPSAPSSAHNTTLNTTSTSLPVQEIFRRSGHWSHRGDVAGGDSGMIYTIVLVPASKQRFSNVESNKKGIKLTAYQRLGTIHLSRPTIQRLSGSDPSEVANADSEPTEKLDSSKDNSLRRSSGSHATVTRSHSSLYGSRAREENIVTRPLNRTSSHGHLSFEEMCRANETKNQDWDSNDLALDDGYTQHGIELLSQRDLTRLQPLLWLELTAVFDKYNLPLVRRKPNKPGNLFGVSLSTLLLRDNQLTSEESNTPLVFQKILHELTNRGVKEEGILRVGGHKQKVEMLCAELETDFYSKPKEMDKLFKRIPCHDLSVVLKKLLRDLPQPLLTVELIDAFYQTHGVKNPNDLAYSLNLLVLLLPVEHRCTLKTLLSFLKLVIENQSSNKMSIHNVAMIVAPSLFPPRYIYPRDRTDLSAQVNMAAVCCQVTEAIITNFDRLWDVPSELINQLKRQAKEERYRKFKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6G0</accession>
    <name>A0A232F6G0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000846">
        <property type="protein sequence ID" value="OXU26225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6G0"/>
    <dbReference type="STRING" id="543379.A0A232F6G0"/>
    <dbReference type="OrthoDB" id="6630782at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF3">
        <property type="entry name" value="LD27203P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127337" evidence="1">
        <location>
            <begin position="25"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="330" mass="38125" checksum="BCE0577FBF39DB2E" modified="2017-10-25" version="1">MKFKRNKFEFQICIVLALVALARCEEAAEKKNEKRGIGHAYGDYASHEHHEHVKTVEVVKKVPVPVEHIKHVPYEVIKHVPYEVKVPVPQPYTVEKHVPYPVKVFVKVPVHVPQPYTVEKKIPYEVKVPVDKPYEVKVHVPQPYEVVKHVPVEVKVPVPQPYTVEKHVPYPVKVKVPVPQPYEVVKHVPYEVKVPVDKPYPVPVPKPYPVTVEKPYPVTVEKHVPYEVKVPVDRPYPVEVQKPYPVPVKVPVPKPYEVIKHYPVEVQKPVPVPVKVPVDRPYYVEKEVPYPVEKEVPYPVKVPYPVPVHVKEQHHHYEGGFEPSGHYGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6T5</accession>
    <name>A0A232F6T5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002648</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01000884">
        <property type="protein sequence ID" value="OXU26067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6T5"/>
    <dbReference type="STRING" id="543379.A0A232F6T5"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.40:FF:000008">
        <property type="entry name" value="Oligopeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Oligopeptidase A N-terminal" evidence="11">
        <location>
            <begin position="73"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="265"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="724" mass="84240" checksum="0C7A21742B94E9E2" modified="2017-10-25" version="1">MTALICGRRIFSMRNSLFKAPRRKESGYYVLLPEIGEDLPEKNPLLKEETMLPEFNRLSIERCIAAIGKQTIEFEQGIKALEKDIEESKNLDIFKDVFEPIEKLEIPLQTTWGISKVLYFGNQSLMPTKSYLSIHKRAWTAISQKYDSQPLNEACKKVNEDTQKLTDEQKRILQKYLLEGRLNGLNLDETERHHFRVLIRQISMKSEEFRQKLEVVTNLFKHKITDPQKMKGFPEEFLKTVAVDPAQYEVGPWIITLKPHIVQTFMEYCPDGLERFNIWLSNVLKCSNHGEQEVETASLVNGITSDRCEIARYLGFKHFAEMSMSTKMAGSLDNVYKFLDTLRNAAFPHQIREIDELTDFARERGFEGLLKQWDVPYWARKQKRTLYNYDEEILKEYFPLPKVLEGLFKLIKNLFNVEIIEREKVDVWHKDVRFFDVYDLEVSDSEPVGSFYFDPYARGDQKLLANRHFGWVLIMRNKSVINGTKPLTSLIYNFQPPLKDGTPSLLTFRGVQSLFENFGHVLQQVLTRVNSAEIAGLSNIEWDAASTSKHLMAHWVYEPEVLKSISSHCETGETLDDETIENLRRSRTHMSGFNLCKELYLCKFDLDLHSIRKPWEAIMKKNWKEHFVFPEDKKDSHVCSWDAIFVDNLGAAYYSDLWSKMLAADVYSAFQESHGDADHQRKIGGRFKDTFLSLGGSVPANEVFRRFRGRDPSLKALIKHLKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7A9</accession>
    <name>A0A232F7A9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000811">
        <property type="protein sequence ID" value="OXU26380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7A9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="325" mass="35617" checksum="FA58080B820E8723" modified="2017-10-25" version="1">MYGTHFLESVIGDPEHLNTIYKRFSHLNRVRCHVASPLPTVGTEELNTRISALETQLADNISASNRFLDANKLLLDENSTLRDKLQQTQQLLRKLHRARQDHDTGSMPVSDSGPILAAGPSIIIEREATEVAGERKCSSPRLAPTGGGAGSKREGAEWFEVIINGLVQDGFDEKISDVVAFALLGAILPALKKSNIASTRVLRMHRSGRAQRNRTTATKSATSRSVLPLLVVRLASPGSDREVMRAKSALADKYLTTNNIKPGVLDPEAAACLTGHKVFINEMLSQEKFSLFKNLRPIAQGLGFKYVWHAGGRGGFYPLKVKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7P4</accession>
    <name>A0A232F7P4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LEM domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_010602</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts (via N-terminus) with LMNA isoform C (via C-terminus) (in vitro). Interacts (via LEM domain) with BANF1. Interacts (via C-terminus) with CHMP7. Interacts (via N-terminus) with tubulin; the interaction causes microtubule bundling and stabilization (in vitro).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000707">
        <property type="protein sequence ID" value="OXU26861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7P4"/>
    <dbReference type="STRING" id="543379.A0A232F7P4"/>
    <dbReference type="OrthoDB" id="118234at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12286">
        <property type="entry name" value="RRM_Man1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000176">
        <property type="entry name" value="Inner nuclear membrane protein Man1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.40:FF:000001">
        <property type="entry name" value="LEM domain containing 2, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1180:FF:000002">
        <property type="entry name" value="LEM domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052277">
        <property type="entry name" value="INM_ESCRT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034394">
        <property type="entry name" value="Man1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428:SF12">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="15">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU26861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="846" mass="94059" checksum="37C28822691DABE1" modified="2017-10-25" version="1">MSVETLSDSELRIKLSEYGYPVGPVTQTTRKILVKKLKTLMESRGSAGSRHSMAARYSSDDTDDDTSASAKNKKKKAPLTTRRQTLANPMPPPATAPIPSMLTAKNAVKKRTSRNLQAADSEDLDVNNVVPVIHTPPPSRTEKIFAKNTKPSKDNNDGLETGSDSDAVEEVPPSPPSSPPVTKFGVGTTKLYNDRAPLTAADVNSPKSYETNWRRTLRESHDTNLRTSTSISTPTSKNERYSVNLPKASTILDSARNDSLSSSKDSTKNDDILSNYDTPYLSEFTRRLSVQASVNLPSLSKTSLKGTKYRLSGLNSTPEAKDSDSNGHFNSPLRPTYPSSSSMTYVTSSLDKTRDVNKVFKSSTVPREEVKNNQNLISMVLVIVLALFFGGLAIVYLGLEGKNDTFPLLPADSDIPICSPVAYDQNKPGSNCVPEESVKDTLQLIKRLHPVLLKRAIAAECYSAKESPYLSTNEIIHMFSNTESQEVRVKESLHMAHLLIFKNPKWGMSLIEIADGNDMPQILDTMEKVFLTRIDGKVGVLIPEPDLPLQCLVRKRILTVFTSLLIAAFGALVVIGCQKLVLAYWRHKKNAEKEVFNLVSEIISMLELHHQSFATTSPGGTQESYLAINHIRDNLIPPKDRKKLAGLWDKAVKFLDENESRIRREVQLVSGEEFQVWRWLPSNSTAPNSPGASATPKMSKVWQGSAFETMEGSVNSPACSPTPCLKIRHMFDPDVEFEEDWETKVKDAILEKCGESVKILHIKVDRGSREGCVYMKCMSQEDAGKAYKALHGCWFDGHLVTVKYLRLERYHERFPEAVNFTTPLKPSNNQRLSMQAHYWTNSSEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7V8</accession>
    <name>A0A232F7V8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000783">
        <property type="protein sequence ID" value="OXU26533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7V8"/>
    <dbReference type="STRING" id="543379.A0A232F7V8"/>
    <dbReference type="OrthoDB" id="6590397at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="200" mass="22989" checksum="F72D9F737CD9BA96" modified="2017-10-25" version="1" fragment="single">PGQLFARRSFRPREKYLILLVFLTFGIVCFGAFFFLPEDFRGNGGVNSVYKVYQRMQKAGPELLIPAPPRSQDEDDNRINAVPVHHGDPRAEDVHLIEDKQKLQAKIDEEYQNQKTLEKPEVLNESRVRASSSSSPLVVRQWIESHETVPPEPSDRMPKIVGGEDKDPIARQRRDKVKEVRVHTSVNSPIDFRAVNKYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F820</accession>
    <name>A0A232F820_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallothionein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000719">
        <property type="protein sequence ID" value="OXU26805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F820"/>
    <dbReference type="OrthoDB" id="7696388at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7689" checksum="FD17830BD9FEFD2B" modified="2017-10-25" version="1">MVWKTIKEKCHLQGKIEKNNDKPKSCGNDCCKCGDQCKRCGTECKCSTKKIYIRSPMFTYYTDTMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8H6</accession>
    <name>A0A232F8H6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000723">
        <property type="protein sequence ID" value="OXU26790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8H6"/>
    <dbReference type="OrthoDB" id="6363363at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF1">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="975"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1472"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1581"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1746"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1896"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1992"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2060"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2350"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1480"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1505"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1518"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1589"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1753"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1784"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1896"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1920"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1951"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1992"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2088"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2353"/>
            <end position="2374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2455" mass="269991" checksum="973123C40BED6F41" modified="2017-10-25" version="1">MGKTTKKPELYHNSQSQNVLRNLMLRDCGLRTTHRTSTKEFEPIAETNFILKKLKELKCDLPGVPRTTFLMVFSPDGTKVASTHGNHKIYITDLTTGKNVRILSGHLRTPWCIAFHPTSNEILASGCLGGQVRIWDLSGGSEVWMSKNPIASLAFHPVDRLLAIATYNEVHFWDWNEPTPFTFITTKNYKEKVRYVAFDNLGRKLITGIANPQNIPDRPRVEHLIRSIPLSRSERITAHRFSVAPSPRVARSAFPHQEPDSNSTRSRPDIVFERIPNEDRVGSPSTSSTNNNVANGTPRNTSYIIDRYAPRTIRWSPFCPQNRPSMPPASSGNSRSSVPNIAIERIPDEDRSNTPPFVNNTSNNVRPEESDDESNDEEFFNSFDRHLRFRRSRLRNRRQRSLGYRLREQLINHMNRDRDASSTSTNSTSNSSGTTNNYLLAEAFAQMLRNILNFNAQETNVCLERLQRNLRLLMEESNQILVHVGMRILRGDLHDTEQNNSTCLQDLYRLRIGLRSRISVMTGLAADNRNPRLQAFINVLNEEVQALNNMEGQLINTNFRIETLRGELSSFMDELRFRQSNQVAANLTASTTARPSDGPTAATSSATPETSQSQTTSEEPRSASIEETRRTTPARTGTRRPWEDTNDDEQPRVTRRRLDNDFEIRLDDIGPDWLNTGFVSSSPSSEDSGLSASGGTGGNVDSSSTQQRGSLNFSVSSRSAFHPTRSSSQRNNSDNRSDDRGPSTSSGRVEPTAPSATATAGRSSANNTNTAAASSTSDFNGLSTRRTSSDVRSAQRLFQNNFDIFWDSFQRYLNSIDIDEQAPATSSNNNDNHENAGEQSENGYWLLEENSNSDSNHEEPPGVTSAAPGPRRRRASRWIQLDSSSRNANTTNDQPTTSTTSDNTANIANDYYGLSRLCLRLQNISNVSLTDQNCLSPISASSTRYEQPPLFPFRSLRETVSQRAEMNQANALARVQNCQTSTTTAASTSTTTSTSSSMNSSMSASTSNSKSTNVRSNTSSNTSINADASNSISTGINVGASTSVNTSTNVGASTSVNTSTNGGASTSAGTSTITSTDINVGASTSAGTSAISGTDINVGASTSAGTSAITSTGINVGASTSTGTSTSSTKIAEPSMSAEAVQNIASTSTSTSSRTREQEVGNVDRSTNTDDPAVRTLEGTVRSIGAATERIVGFEQDFRKLMLFGRHFYNIQSLSGVRLQIFHLLLVRRMWERLQICIKDLVNTINVCDSFEGTHNNDKSQPSTSREGSFAPRTSTSDVESLTEPARNFKKALLDNYKRENNGNEADQPQPSTSTTSTVLDSQETTGSSQPEPSTSSDVPATGSKEASTSSNLSLPNETELNKKRHEILRDFINTFFSMYKLKDANSFTQMLGSTLPGPSNDHTYSNLSNNYNPLSRSFADNSNNSSNNIQLPSTSSLVNDISTTISNIVNDISSSYASLRLPTVVGFLPSSNNNPSSSDATTSRAGDVGPSTSTGNSNDAVAGSSSSQITDSSASSNMSESPTNSTSIQERQSRYQRVWRYGRRMYLRRPRLLSVGPRNMKRIARMQNFSHIYRHYDQLRRNQRNRNTATPSTSTIAGTSTTTDNTDRDRSQTFESFQSTISSLRNLIQQRNTCMYRRQQQQSANRAPGACGDLQNKFEDIFGVVERLKARLSTMVQNLTDSFQQNRRAIGRTNVLREQILEIYVLQGLGLQHTNLLLEHLFATKRNLESNYYGYGSLLSTTQPVADNAQPSTSTGTSTTSSAEVLTSTTNTSSNNGPTVMPAASNSTNTGSASASTSTNIAGSSSSNNSPRDTLARLSRLFEINGTTLRTASMLANTSLGVGSDFVSSTSMTANASTLSFESSDNNDNSLANDSRNENALSAEIQSIIERIQNNTNNAVDSSQRYQSRSGANTRFDNDSDDREDDEYAPSVSNPPNNDDPIQNRESGRTWPTTTTNPPSIGLFRRNPLERLMIIQRCHALHRRLQYLLGNNNSSSNNTSDANTSSLPERGRHPDFSTFFNSRSDGLNPMSGASAAAGSPSAALRQYLNVPVIRINNLPVDSSWGPPSPPLIRRRRPSRSRGDRSSATMGNATSSTAPNNDSGYHSASSLYLNSIRRQIQQIQQRVYTQASWRDVWRDGLVSRAQSLFRAGEGSSGGQDPENDSDDVEIREHQINMAFNGLEIQSYRIQAWDFSSIPEIHDSKKNVIVRDCKIHNDASIDISSDGTLLATLMPTGNYSPTTTIGVYSLQWESLGQKVYSTQTDQTVISVSMSPTKQHLLVGLASRRIPLPARPIPMALIYKLVDPETDPIDSGNINAPQRPDYSSRHAEYICIINNYLNDLRRLRTNDEHQQNGNQSQQQRNGNQQQAPQQNGEVRDRLSRLTRVALAAMNSRTPLYPDASDGKPIRKSMILLRELLQNRETPSYMSLNCIRWAPQPGQGMVYATNTGLLNILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA35</accession>
    <name>A0A232FA35_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000553">
        <property type="protein sequence ID" value="OXU27711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA35"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11195" checksum="C25AB743E4DE4ADA" modified="2017-10-25" version="1">MTAMLTAMNGWRAVCNYKATILKIVTKDEGVRQRDKTETPRNGVARSCVEEIRDEEDEARWPLLRVGKVTDRICVTVRCMNLDVKQKDFSVVRIQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB97</accession>
    <name>A0A232FB97_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000546">
        <property type="protein sequence ID" value="OXU27760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB97"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="132" mass="15353" checksum="F987DA50FFA02514" modified="2017-10-25" version="1">MTMFAFSNAAKCITYSKCGCIPGAWTERMFQSEISFIFITYHALSSRELVVLSNSRYKFFEGFFIIESSSSQSTWDYLKDKLGLQKKSNIKQDITEELEASYLEPEPIPVHTNSTEEMWKPGYRGRTENKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBB4</accession>
    <name>A0A232FBB4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase A2</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_002628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000475">
        <property type="protein sequence ID" value="OXU28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBB4"/>
    <dbReference type="STRING" id="543379.A0A232FBB4"/>
    <dbReference type="OrthoDB" id="8187220at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000002">
        <property type="entry name" value="Phospholipase A2 group III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013212078" description="Phospholipase A2" evidence="13">
        <location>
            <begin position="23"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="14">
        <location>
            <begin position="157"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="292" mass="33091" checksum="C63F54D2320726F9" modified="2017-10-25" version="1">MRSLQCILALNVVLILVSLANAQFYENNYDDNDDEISNETEDDEGLYVDNRIDESPTFVSPVEKFVKAVTNGADNGIGRLISGITKPIRNIVSGNPAGRAVKSGFGEVLNMIGDRFKAIYPGRVFCFSIFRYLMEKLYSWVTSRTNGRVTMWKILYISGTAWCGAGDVAKSSDEVGLFSMTDNCCRAHDHCNSNINAGESDHGLRNNGIFTRSHCQCDANFYHCLKDVRSIVATNIGITYFNILRPQCFKLEYPAHCVRYGRSRLRSNKCLDYDYDYSQNKTWQWFDSPDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBB8</accession>
    <name>A0A232FBB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="4">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_007581</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000510">
        <property type="protein sequence ID" value="OXU27922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBB8"/>
    <dbReference type="STRING" id="543379.A0A232FBB8"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03706">
        <property type="entry name" value="mtEFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000085">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF2">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="54"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU27922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="462" mass="51642" checksum="35A2DBC9173D4721" modified="2017-10-25" version="1">MLLQRILLRSFNCARSQRLSLNVKHACQINLDYFHTKANWSKQRFYSSDANDKDLICSVGTIGHVDHGKTTLTAAITKYLSEKDKNCKYVSYDEIDRAPEEKARGITINIAHIGYRTKKRRYAHTDCPGHLDFIKNMISGASQMDGAILIVAATDGPMPQTIEHLLLAKQVGVKEIIVYINKADLVDEEVLDLVDLEIRELLDDFGFDSENSPVIRGSALLSLKGDTSNYGTPSVQNLLDAMDSYFSPPKRDYTSPFILPCDNLFNVPGRGTVVVGTVKRGIIKKGAEAELIGFDERIKTVLSDVQIFQKSVPEAPAGENVGVLLRGVKINTVRRGMWVVPRGSQKFSNHYEAQLYLLNTSEGGRHRPLGKNGYCSIMYCSTWNIYTRVDFILPDGQNMLMPGEQATCRLTLLDCMPILMGQTFTIREQKCTVATGIITAVHDRVEFDKRKMNEIKIPGVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBE7</accession>
    <name>A0A232FBE7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000470">
        <property type="protein sequence ID" value="OXU28156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBE7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012240704" description="Single domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24328" checksum="06E56119BAAC71D9" modified="2017-10-25" version="1">MKTIFIFCFVIMAVTAFGQTQAAPDQAKREKRYLAIERCPENSSSEGCITYAEEKSKEIKLCHTFEMRMNRIYWQGCGTVFCGENTKLVKKDLSMPFPDCCEYCLIIDDNKEAYASDSSRILHPTTVSSKPCPEKLTTAQCEAHIKAEIAKEKSCISATVRNTIIQLNSCKPCSQVPGAWKIIEADIKKPFPECCPSCELKPLKSSNYYLSMKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBG8</accession>
    <name>A0A232FBG8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000540">
        <property type="protein sequence ID" value="OXU27799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBG8"/>
    <dbReference type="STRING" id="543379.A0A232FBG8"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="91037" checksum="CB12DF50C3838A1D" modified="2017-10-25" version="1" fragment="single">KMLVSKCVFYFFKIFGLATMRLDENQTVRDSWCSGSKKGQVYNAILTCSIIASNCYVARLVYKENLSHREFEKTFDVVQYVYTTVTVVVILTVFCFCQERAVLIANNLRKTYVLVENINGQLSKKEEDLVISGLKRIWITSTVIWISVVFTTSKLQFAVVMYYLTVYPCILIVNFAFLQYTIILHLLKQLFAILNANFLYISTRQSVVTRKVEAAHSSFQAAEQSSQQFSDLRRLYMLLCDLSMDVSKFYHLIMLFCVTYVFSTLTMWLYYITVPLVTGTTPSKLQYIHSLMIVTYHIFMLIILTKSVDAVVQEKNKRTGEITNGWLANLQNQQLVNELNLFSNYLLHKNVSFTAYGLFSLDESLLMSKKFLFFVTFNEVPIQITGSITTYLYKPTEKKMVVLKCVYYLFKICGLATMKFNIAINNRLQDSQWTSCKRGIVYNAVLIFFLALTTCCVTLFVFDLNAVSGEASTLFIILHYIFTSVTAITILTVSCFCQKDAILIANNLKTAHLLIENVNRQLSNEKPRVMSTLRRICTVNLIMLILVIITTLKHDFKTVMYYLTVYPCTIVINFTFLQYSLILQLLKQEFAILNANFQYVIRRRLRETASNLHQACCRETTTTFPPDLYKLYMSLCDLSMDVSKFYYLVMLFGVSYVFMTLTIWLFVIINPVINGIMTQPISEYVHSLMIFIQHLIMLITLSKSVNAVVLESKKTAEITSRCLTNLNNEQLINELNLFSSYLLHKDVSFSVYGFFSLDESLVISTQIQIAGSITTYVVILLQFHKSSGQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCZ8</accession>
    <name>A0A232FCZ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_010405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000416">
        <property type="protein sequence ID" value="OXU28555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCZ8"/>
    <dbReference type="STRING" id="543379.A0A232FCZ8"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353282" description="BPL/LPL catalytic domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="667"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="936" mass="103828" checksum="2CC680D54DC82EBB" modified="2017-10-25" version="1">MLLTIFYMVATWVQSWRLSSLRARLQAILLGPEATRPSIMLYTASQLSVKDETNGNKSKLQNGNNISKDMLSSHLCSNSNLAKLGDLLWYQGDKRLCTIYPQQKVDVSHWLLYPYGKTVFPLFAHNNAQATLQQNAKMHVLIEADLSNYIPLASSKATKLEDYGIIVTWMSEDIFGVILETDLEHITKFSTTLMQGQCFINNGLPVTRIESVSVTGKPCICNYERFNLVESRKLIGSSQWNTYVKKLRLVSSTARLVSQQNEAIEIKEIPGLIVSPGSKPVTLQMPTILEIKIPNDETEDHINSSVPSTPPPTPASATAVINGTASRLSQALTNSMDLSVGSLSNLSSSRSQEFVLEESSQENLSEFTPLKSVKNTKRTSDRDSKMSSVMSSKSSLSTVNYSPRKTELDSKVTKPPNILICADSAVASDNVRSVLDSILKENKYTVYPLSAQEARKDVWMDQASLMIVCGNVGNDVASKVVEFLVHGGKLLALCSDILKTLLPTFKTAEVRENELVRFSYGKWKHVRMMHHVFSNLPESGGKAVFSQIHLEADPSQYEFEESKFLALKQSNATRLEIFSDLLNTHLDIEVNAKPRIPPTYSSGFFLGRHELKLEMLKKLKDKMQPNDVLKTTNLEIQFCGTSTVPKPASSTYLPVMVHRCPDNFSTVEYFENLSTEALGRLVIYADVMTSSNAAINGFALHNGLAVICRSQTKGEGRGKNVWLSPEGCAMFSLQIHIPFNSILGERISLIQHITSVAVVSAVRSIPDYQDIDIRIKWPNDVYTGNGSKLGGTTVTSTIQSPTIICNLGTGINLSNSSPTTCINDMITKYNQATGKKLEKITLERFVALVFNEMEKLINLIQNNNMDEFYDIYYGYWMHTDAEITVILPDGSSQEVKILGVDDYGFLEVQGKNGNIFTVHPDGNSFDILSGLVAPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCZ9</accession>
    <name>A0A232FCZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000394">
        <property type="protein sequence ID" value="OXU28684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCZ9"/>
    <dbReference type="STRING" id="543379.A0A232FCZ9"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU28684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14586" checksum="0ECCF2F6B8ADFD16" modified="2017-10-25" version="1" fragment="single">CDRFAVGVYSLIGAVNPDSFDILHSYSNTFQMPFVTPWFPEKVLTPSSGLLDFAISMRPDYHHAIIDTVRHYGWKKIIYLYDSHDVQEPPEKKFSSEAKSSSQQKPEYYHAHEPPIHPYPTRPFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD62</accession>
    <name>A0A232FD62_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000432">
        <property type="protein sequence ID" value="OXU28433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD62"/>
    <dbReference type="STRING" id="543379.A0A232FD62"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF41">
        <property type="entry name" value="CASPASE 14, APOPTOSIS-RELATED CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="189"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32791" checksum="105EBECE41563340" modified="2017-10-25" version="1">MNFNMISAFSTGEASETKLDKENPVFQSSSCDKESIRKSYPMDCKFRGRCLFFGNGLFDVKRKRDFINEDSLLIKKTFTNLGFKTKSYIDLEYQNIKHTLDKLTRQDFTNDDCICIFISTHGESDGLIWAKDVCYPFIKTFEDRIASIKSLINKPKIFFIQACRGLQIDKGICSSEVTSSEDEVDGNQILTKVSIKADIFKAYSAPPGFVSWQASLFIREVCKSFNKYGKTADLETIVKIASREVRKFENKSKYSARNGANQIPYIEHTLDKMVYFRDKESPSTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDM4</accession>
    <name>A0A232FDM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Brain-enriched guanylate kinase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_010925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000406">
        <property type="protein sequence ID" value="OXU28620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDM4"/>
    <dbReference type="STRING" id="543379.A0A232FDM4"/>
    <dbReference type="OrthoDB" id="10068192at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043441">
        <property type="entry name" value="Tjap1/BEGAIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664">
        <property type="entry name" value="TIGHT JUNCTION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28664:SF4">
        <property type="entry name" value="TIGHT JUNCTION-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="78"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="87994" checksum="02CE632C9D2CC4D2" modified="2017-10-25" version="1">MADKCKECGCICKQCNKNEQRHNDMHLHVEIENLRQCLVERDNHIVTMETQFLNEAEKFPNGEMASLKEEVLIWQDKYTRLYEAYKRVQKVNQNLEDKLLRIVDKCETEKGAFTKDIATLSHRLADANYTIHRLTQDNEKYRNDVNLAIQLLQCKPSNFVGQKYESLPPEVQAKVRTYVAQKTRISEMSSTEVRSITVPISTFPPTAMVYNVAKPVIDKQDDHSDDESKPPVDMVSAAIMAKVLEDREKERIFARHCNTCTCHRSVLKVDTESQTTFEQDNDRLLSTKDYFSDFNDRNDFRNVRNGNKEFRQLDGGETGSNRNKLNTQLNDLNANRATFHCINEVTEVKYNANGETSKKYNRYISNAKNNLNLKNSSIYKCETNEANLSDKSRLTNEDRIEAQPSLNNMNKLTKETKSIDQEQAKIDMINERLWKNGLINSKAMLNAKESDVQLEVINERVWRNSKTSSIGSSSRSRSSKSKNISEKPARLTVIEVKSSDDVRNESETTKTEPTTSPSFSGDSVLISSSDPSSLSSDLVTNQTTSKTTTTAAVRQEPKLSGPRNCLMRVTPGSKNILLDNAGAYQTVLYTSGCSRPNTALVHLAKSSRSGRSASISSEESSTVAPCNTLHDNNHLQRVAQWVDTLSTDCHPQAVGAQTTDCEDVSSQEPLLGDDSKAAKRPPPQPDSQTTALLQAQESQPQPLSDLMTFEGSSDDEHKLTLDYESYQANITKEMEETYLKLAASLDSTKLQQSDNLADIGMMTIEQYRQEQKRKSFHAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDW5</accession>
    <name>A0A232FDW5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative elongation factor E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_007129</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM NELF-E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000392">
        <property type="protein sequence ID" value="OXU28693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDW5"/>
    <dbReference type="STRING" id="543379.A0A232FDW5"/>
    <dbReference type="OrthoDB" id="378874at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033102">
        <property type="entry name" value="NELFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17250:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU28693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="273" mass="30944" checksum="E7CC6E4A1462FD19" modified="2017-10-25" version="1">MVYLHFPSNLTEEEIMLQAKYNKLKRKKKALQDLKTPKPEPERIPQAPKRPTEARDAREVAKKLIKSGVITAPKTPKRPEQAFKRPRGLERKLNSTEKTVSSYQPFSATQPEEDDTEPSRTKVVKGLYDSFVSATDTEDRGAPEKPISSKPNETKPIKGNTIFVSGYKISEDFLKKHFSTFGNILKITMEAEKKGFITFEKPESAERAISEMDGIMASSIQLKVSMARRQPVIDPINDTTSSSMWSTLAASYTQKSAHKDKRDIKVYDDELFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEP3</accession>
    <name>A0A232FEP3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000358">
        <property type="protein sequence ID" value="OXU28909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEP3"/>
    <dbReference type="STRING" id="543379.A0A232FEP3"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19871">
        <property type="entry name" value="DSRM_DUS2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044463">
        <property type="entry name" value="DUS2_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="6">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU28909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52256" checksum="3AD5F4F3FAC373F1" modified="2017-10-25" version="1">MTNEETEASRPRLTYADKLIMAPMVRIGTLPMRLLALEYGADIVYTEELIDWKLLRSVRRVNEVLGTVDYIDRTDGTIVFRTSPTERDRVVLQLGTCDANRALKVAKLVEQDVAGIDVNMGCPKRFSILGGMGAALLKQPEKASEILRTLVGGLSIPVTCKIRVLGNVEDTLKLVDTLVDTGISAITVHGRTVDERPQHPNRSEFIKRVAEHAKIPVIANGGSKEIEKRADIFKFKKETGCSSVMIARAAEWNCSIFREAGMLPMEDVIKSYLKLAVDYDNSPSNTKYCVQNILRELQESPLGKRFLDTQTLEQICEVWGLDEYCRTKQKEHRDRGFGGRFEVVPERLSLIDGNSGVGKRKLDEEEDVLLMRCAFLRNNYADDTSLPKSRLAKWTRDNRKKLPIYVTHHEDKLFRSVVQVDGRKYGSSFWEKSKKWAEQGAALACLCALGVIDTETLIKSGSLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEZ3</accession>
    <name>A0A232FEZ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000316">
        <property type="protein sequence ID" value="OXU29272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEZ3"/>
    <dbReference type="STRING" id="543379.A0A232FEZ3"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF66">
        <property type="entry name" value="TERMINAL URIDYLYLTRANSFERASE TAILOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU29272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="727" mass="84822" checksum="A0BCFDC5CC526959" modified="2017-10-25" version="1" fragment="single">MRCANYKCQRELFVNSMDLYCMTYINVNVLFYFYSFIPTSRGIKVKNCKKRKMEEDDKKCKICNKIFQSEHDLVTHLNSFTHQRKEWSQRAVFINCVSCDICIDEIIKCISQFGQIKKYNVIPNDGFNDVTIEFQDKKTREIVLSKTIKVRNKQLHDETPSLCYDKIKTVFNSKSSFNDQLQAFIKAVAITNDDVKQRYEPVCQTLDRLFQTTLSKLKSHMFGSTVIGLGFKNSDLDIFLNIGIPVVEENTCISGPHVITLDRLFIIIEKVLRSNIDLFTNFCVIRTAKIPIIKCFYLPTKVRCDISFKNSLALYNSKLVHYYLSSDVRFTPIMMLIKYWLHINHMSNNISITKYAITILFIFYLQQIKLVPSVSKLQEECSVPILVKGWQVNFNKNFQQSARHSAENKYTNKSIPEILGEFFEFYSNYDFETQVLCPIDGQSYSREQFKEGNCLSPSQMRYIKYLEVDKNPRVLHTWKPICLQDPIELNHNIMKNVYRANLEKLQNYFSIAAKIVHDSSENGYIDLLKKLFNEQNYIVKYNRIKQESISLEIQVAELFASRKNGNLIKDISNNNTTWFGITSNVVKQILEKVLNFQVNEDKTNPEVENVTVLHCKGNQCLWFNRKNYKVNRHIPNALEKEILITKMLIDDMEKKNDLFLVSDIIMDVKCHITRKATPNDCVVITVSDNGCSGKIFNEFVNYFLLKTPSILKQVFEYLSTNDSDESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF37</accession>
    <name>A0A232FF37_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000343">
        <property type="protein sequence ID" value="OXU29049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF37"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="223" mass="25028" checksum="30E0D76BE5D475F1" modified="2017-10-25" version="1">MDSEGYTTRKAEKSEASAIVSFLHEHHSPEAVITKGFFAKNRARITDAEIQLMDESWEKFVSEAPSLVTIHKASNQIVGAIVLVPVDNPNLYSEEKPSGERSKILDEFDVIFERIYAEVNLVDRFPQAKRAMKLRSMAVHKDHRGKGLAKVLLRESVNWAKKHGFDLVHSFFTFPAAKKAALRSGFSKVMDYDMHSVKDTDGSCAFADLSPNNVTSIMALEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFQ7</accession>
    <name>A0A232FFQ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_012209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000317">
        <property type="protein sequence ID" value="OXU29269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FFQ7"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20958">
        <property type="entry name" value="IgI_5_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000302">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000308">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000324">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF101">
        <property type="entry name" value="ZWEI IG DOMAIN PROTEIN ZIG-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="162"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="249"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="347"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="438"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="534"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="712"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="810"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="907"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1296"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1490"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1587"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1684"/>
            <end position="1776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1808" mass="194866" checksum="D90D4522A0BB5C25" modified="2017-10-25" version="1">MMLSTLYYGPFLTITEPVGSARPKFPTMATQFNAMLHGSMTLLCPAQGFPVPMYRQGCQWYEAFNIGKKNCRFALSRAGFPVAVIQPTTCKAANTIPNCRWYKFIEGTSRRQPVPLNERVRQVSGTLIILEAQVEDSGKYLCVVNNSVGGESVETVLTVTAPLSAEIEPRSQTIDFGRPATFTCNIKGNPIKTISWLKDGKPLGHEETTLRIESVKKDDKGMYQCFIRNDQESAQATAELKLGGRFEPPQIRSAFHEETLQPGPSVYLKCTASGNPTPEITWELDGKRLSNTERFQVGQYVTVNGDVVSNLNISSIHTNDGGLYKCIASSKVGSAEHSARLNVYGLPFIRHMDKKAIVAGETLRVTCPVAGHPIESIVWERDTRVLPINRKQKVFPNGTLIIENVERSTDQATYTCVARNAQGYSARGTLEVQVMETPTIQPFSFTKLPMNAGEFANLQCIVSVGDLPLKIRWSYPGERIGGASGVLVKKVADRVSMLMITAITAKHAGDYVCTAENAAGTASYTAELVVNVGPQLLPIAFNTESANQGDSVSVTCSVLKGDMPMDITWAFNSEPIQPSADQSITIYRVNKHLSTLSIDGATARHAGEYSCTASNVAGSVSHSTQLAINGTFYSSPVDRHISINSDRTKFCFRHDRHIKYVDRFSFSFPNSNRLIESTYVNNQLIHLTNHKKAFAYFPRFSPGNYTLLTVAPQILPFTFGDEPANWGDLVSVTCSVAKGDLPIEISWAFNNVLLKDMQHYDITVASTNRKNSVLSIESVNAKHVGEYTCLASNHAGTASHSAYLSVNVVPQILQFSFGEGPLNSGEMLSITCTIIKGDLPVNFTWTFNDEPIDLDVDSDVNIVANKRVSFLSIDKVDARHAGDYKCIASNAAGADSHTATLSVNVAPQIAPFEITEAPANSGDSISVVCAVVKGDLPMEITWSVDGVPVREKHEDVGVLATTKKNSILSIESVAARHAGIYTCSASNKAGAASHSSNLIVNVAPEIAPFVLGDKPANWGDTVTATCTVIKGDYPIDIKWALNGKPLDRQHEEITVVNTGKRVSLLTIDGVRAHHAGEFTCTASNAAGGTSYSTMLTVNVSPQIVPFVFGDEPANSGESMSTVCTVSRGDQPLEFAWYFNGEKLIADESQGLLISTKKRRSLLEIEAVSYNHAGEYTCSVSNEAGATSHSSVLVVNVPPQVAPVTIGDEPANWGEQVSATCNVLKGDYPIEIQWTLNGEAITSTSHPDISITTSGKKISFLVIDSVSAHHAGEYACIATNLAGSTSRSAILAVNVAPQIMAFSFGDRPANSGESMSATCSVSAGDQPLEFSWFFNDEQLTLSNSHDVTISSSKRRSWLEIDAVSAHHAGTYTCSVSNEAGAASHSTVLVVNVAPQIVPFSFGDGPVNSGESMTTTCAVSVGDKPLEFAWFFNGQPINTQDNPAISVSINKRRSTLDIESVNAGLSGEYTCSVSNLAGATTHSTSLIVNVAPQIAAFAFGDEALNAGDAASLTCSVIKGDSPLEIVWMFNSEPLETRQHDIIVTETGKRTKQLTIDSVDARHAGEYTCIASNIAGSVSRTAALAVNVAPQIVPFTLGDGPANSGETISAFCSVSLGDAPLEFSWYFNGEKLSMNDRQDLTISTSKRRSVLEIESVKAHHAGEYTCSVSNGAGATSHSSVLIVNVSPQIVPFTFGDGPANSGESMSTICTISRGDYPIEFVWFFNGEEILTSNREDLSISNTKRRSVLEIESVSAHHAGEYTCSVSNAVGAASHSSVLIVNANDLICVDRKKTRKYFKCFKFLIIFNLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGN9</accession>
    <name>A0A232FGN9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UNC93-like protein MFSD11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000219">
        <property type="protein sequence ID" value="OXU29921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGN9"/>
    <dbReference type="STRING" id="543379.A0A232FGN9"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF0">
        <property type="entry name" value="UNC93-LIKE PROTEIN MFSD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="391" mass="41777" checksum="B8BFE85F0323D3A0" modified="2017-10-25" version="1">MTGPRTSIVAGCACYVFFIATFLYPRTELLYTASVIVGLGAALAWTGHGLFLTVNSDGDTMSRNSGLFWAIFQSSLFIGNIFVYFVFKEPVIKEDVRNLVFKVLTGVSVCGLVLLLTLRKPPQQVNMGPAEGVSSADKELQIPEPPREKPLLAAWHALRDAFGLFFTQRMLLLSLTFIYTGLSLTFFSSVYSSSIGFTKGMGEDRKSLIGLSGICIGIGEVVGGALFGVLASRFNTCSGWPVVATGFGLHCFAFVAALLNLPNGAPFSDTDETGLIAASPALAMAGSLTLGLGDACFNTQVYSLLGTVYSTESASAFALFKFCQSVAAAMSFFYSSHLGLHGQLGILVVSLVLGTVAFCYVEMKHRRAKRLSTNSCPEIDGDKGNTSLYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH21</accession>
    <name>A0A232FH21_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000244">
        <property type="protein sequence ID" value="OXU29758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH21"/>
    <dbReference type="STRING" id="543379.A0A232FH21"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="175"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="343" mass="38580" checksum="7B7B1F48DD0A040C" modified="2017-10-25" version="1">MTDRTRLAYVSAAVVGAGTAVFFVWWWWTKRHQRHRPPSKWRKVGELSDLICFPVKSLGPIRVNSMECTMLGLKSGWMRDRTLMVIDLDGQFVTGRQMPRMVQVSPSVAGSVLTLKAPGMMSVSVDLARLRGRFRAAVWGQAVPACDCGEEVARWLSRFLLQEDTGLRLVYYPLDKPSREVRSKNQVFPLTDSKDTGAYPDATSYTLENEASIADLNTRIEEPVTPLHFRPNFVVKGAEPLEEDTWDWIKIGNVVFRNVKPCTRCIFTTVDPETGKKNPKIEPLKTLRKYREITDPEIRPHTLGSPVMGIHLGLRGPNGIVRLGDPVYVGVPEEPETPLVSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIJ6</accession>
    <name>A0A232FIJ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000162">
        <property type="protein sequence ID" value="OXU30413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIJ6"/>
    <dbReference type="STRING" id="543379.A0A232FIJ6"/>
    <dbReference type="OrthoDB" id="7699712at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="127"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="333" mass="37684" checksum="3551E2EC42ED2DFC" modified="2017-10-25" version="1" fragment="single">ETNASTGLGPYPGGRSVIRQSFKKKNLEETTIDIMTSSITESTTKQYNTSLQYWWNFCKDKGQDPYYAEEDIVINCLTKKFNEGAAYGTLNTLRSAISLINQRDNSNSLLINRFFKGVYKLRPNAPKYCSTWNVDDVLDMLETWSPLESLDLQNLTLKLVMLLALGSAFRVQSLALIKLNNIKKLSSGIEIRILDLIKTSKPGAAQPYAFFPFFAEKTSLCIARTLIYYLQATKDIRGDTQELLISFKRPYKKICSQSISRWLKTVMRKAGIAEEFTAHSTRHASTSKAVNQGLDISTIKSAATWSEKSKVFSKFHNRPIKGNERNFAETVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIQ7</accession>
    <name>A0A232FIQ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_003940</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000136">
        <property type="protein sequence ID" value="OXU30644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIQ7"/>
    <dbReference type="STRING" id="543379.A0A232FIQ7"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00577">
        <property type="entry name" value="OPSINRH3RH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="85"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU30644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="408" mass="46044" checksum="52599650FD340268" modified="2017-10-25" version="1">MMYGNDSSLLNPMAFVGLNGAMGGMGPAGVGQVPQMQEHLLGWNHPPEHMDIVHPHWRGFLAPGKYWHIGLALIYFMLLVLSFVGNGCVVWIFSTSKVLRTPSNLFIINLALFDLVMALEIPMLIINSFIERMIGWGLGCDIYAALGSVSGIGSAITNAAIAYDRYRAQLCTIFTLFPLRRRTISCPIDGRLNGKQAAVMVAFTWFWTMPFTILPFAKIWGRYTTEGFLTTCSFDFLSDDQDTKVFVAAIFSWSYCFPMVLIIYFYSQLIKSVRRHEKMLREQAKKMNVKSLSTQDKERSVEMRIAKVAFTIFFLFVCSWTPYAVVTMIAAFGNRELVTPFSSMLPAVFAKTVSCIDPWVYAINHPRYRQELTKRCQWMGIHEPDSGPSQNNAEAVSVTTEKLKSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ58</accession>
    <name>A0A232FJ58_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000154">
        <property type="protein sequence ID" value="OXU30498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ58"/>
    <dbReference type="STRING" id="543379.A0A232FJ58"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19136">
        <property type="entry name" value="AKR_DrGR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="4">
        <location>
            <begin position="331"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="692" mass="77792" checksum="5AB0D905F6EA5FFE" modified="2017-10-25" version="1">MSIAKNSVHLLSGYDMPLVGIGTYKVTGREVIKRVIDESFAVGLRLIDTAVVYRNEEDIGLALKELLPKYNLKREDIFITTPSDNGNPDKIRKSVENSLKALNTSYLDLYLIHWPGSSRIQENSPHNPKHRDTTWATLVELQQKGLLRSIGVSNYTVGHLIHLLEHCSGVKPDVNQVECHPHFRQDEVIQFCERHGIRVQAYSSLGTSDSTNLLEDPVVKKIASQLSVSPARVLLKWALQRGLGIIPKAIKSDHIKENIKLDFEIPKHQMIYLLCLPQQKYAWNPDNDEIAKLCLDKYASLKKTGKPSNCEWTVLSGIVLQNSSKELCVLSLCTGTKCLSGVELRSTKCNERGNKLSDSHAEILARRAFLRYLYHQIELVISNKKSDIFYLEDNGIKLRNVSFHFFSSQTPCGDCSIIPKLTGETEDLVSPPKKARTEDESLASQFGQAIVDIYRTGAKCVDSDERQDPHEKGINYHTVGPLRTKPGRGDRTLSLSCSDKLAKWNVMGVQGALLSLMIPTIKFESIVIGGGCPYSLESMQRGIFQRFEPNIGAPEIVQSQISFEHRKNESRTRPCPSSIVWCLVPEKPIEIAVNGLRQGATKKKNKSFNLLISRKEIFKTFLTIYDKFLKGQIYKTRLLKLEYPMPTHVSNTWFCSALVSSSSLTFSSLKILTLLASVGLQLLLKHLFCLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL19</accession>
    <name>A0A232FL19_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_011026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000071">
        <property type="protein sequence ID" value="OXU31283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL19"/>
    <dbReference type="STRING" id="543379.A0A232FL19"/>
    <dbReference type="OrthoDB" id="6250271at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="461"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="585" mass="64042" checksum="B265789C40737A40" modified="2017-10-25" version="1" fragment="single">IPDEVLTWHGVHRSLTKYSGIQRSVIIFALSFLSCADLAFSKVERCYKCFSELNYDCSLNANQEKFIVNCKDDIGGFIGKLKTTNSSERESSNSTEYTCVKAVITMSLVGNTTTTLVARGCGNKDTCDTKASYPALNITAIKTCNVCNYDLCNSSRVISAGFYGVIISLILLFSVIVIALCFLFSIDSVFSTVEKCYGCTSLMDVDCVLNPKQDKFVMDCKNSTFRQGIDSMRIFNGRDNKAVDWVCAKATVSNLLSGNKTMKQVVRACAPKNACEQKASPDVTVNSCDICTSNLCNSSSVISVGFYSLTICLAMIFIGLWGYGRIVLFIIAIERELVNNNKILIFAAGLCELEIDQSNIILDIEESRGDSIDQETVPAELPVIGDPRNETILDLTATGSQPLFTLDGKKLKLLRPLDRDDENLSHVVFQLSCTVRATRSNRKIPVIVRVSDVNDNAPKFINTPYETTVPELTPVGSTIFKNVVATDADAGVNGLVEYSIAPGDGTGIGNSDGVGRDRITTADGYGYFSINLPHQGQVTVNRTLDYERTQRYFVTILASVSDFRSALRILLAGCFFRNVIKSGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLR5</accession>
    <name>A0A232FLR5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000045">
        <property type="protein sequence ID" value="OXU31602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLR5"/>
    <dbReference type="STRING" id="543379.A0A232FLR5"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012285631" description="Peptidoglycan-recognition protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="6">
        <location>
            <begin position="68"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="5">
        <location>
            <begin position="83"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26628" checksum="2B3C159C4A41D5A4" modified="2017-10-25" version="1">METVTMSLGRLLAVLVFGVALASANDKRGKEMILKNCHCTCFDEDIPHPDVCNATTPGACNAYADAEVVFVSRSEWHARPPIKPLLDLETIPAPYVVISHTATKSCFTKDQCLPHIRSIQAFHIESHGWLDIGYNFLVGGDGLVYIGRGWDKQGAYTHKYHQNSIEISFIGTFREETPSAAQIATTKKLLQIGLRENKLAKDYKLLEHKQVGVPHTQRPGDHLYDIIKTWEHWDPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN55</accession>
    <name>A0A232FN55_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="10855" checksum="DE8BEC155C868F06" modified="2017-10-25" version="1" fragment="single">MVETKVVGYRRGNPMVTLDLTLNTFFKEPHSFIAGIERAVNFTFRMVCSVAALKVXPWIVSWLFKASVTIQGVVKLRETRQRSTNQHLTCNDDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDY2</accession>
    <name>A0A232EDY2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005839">
        <property type="protein sequence ID" value="OXU16532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDY2"/>
    <dbReference type="STRING" id="543379.A0A232EDY2"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031986">
        <property type="entry name" value="GD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF136">
        <property type="entry name" value="GH08193P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16030">
        <property type="entry name" value="GD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127328" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="302"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU16532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="556" mass="62934" checksum="50B7EA2B075579E0" modified="2017-10-25" version="1">MRPAFYVIAILAQFFAVTQCQCPNYYRVLRNETTREIMGVINIAIPDAPKAVTLRLIVKLNVGTALSPKCIKETRIELEKSREESIRFVLDGKPIFYRIYFPFQYPMPEITSITLNNVPFCKGQPSHAGMNIVVTMEHTLYPSRLLNVPLSDQLLGLFYNRAISSTRSPSTTSTTSTTSTTSTTSTTAIPHVELEVPEDIEEDIPDSVPDVKSEELEDIEEGIAAVRDVNPVVLEDIEEGIAAVRDVKPEVPEDIEEDLPDSAPMDYDGMQSDLPEDSPTSEPNKRIDSTCGVTSDSFAYGIIASDQTVSPKQWPWLAVISMRTENDDSNFKCNGNLISNQYILTAAHCLEDKNGEMIPADKLVASFGLSDLYDINDQETVNVDVFEYKIHPYYTENPSSADSDLALIKLKERIEYSPIIRRLCLWTEDADVQDIVGRPGRVVGWRKHKLQKSQWQPRRSLSRKTQIFELQIESQEDCLSGKYAEYFGAMSDRTFCTKRNASEGPRDNDSGSGFVMYNSRLDQYQLRGIVSVYFEDYVFYVDIAKHQSWIFQEIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEB2</accession>
    <name>A0A232EEB2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005450">
        <property type="protein sequence ID" value="OXU16668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEB2"/>
    <dbReference type="STRING" id="543379.A0A232EEB2"/>
    <dbReference type="OrthoDB" id="7697830at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="170"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="295" mass="33394" checksum="4A064F833EDEFAF7" modified="2017-10-25" version="1">MLKFNETTPLSKHLICFDEMMVELQAAGATINTSRQRLAFVKIKLLDYEVKLQTEKSETSAKVLQIETITSADKKNKKNKIFKGNFKKKQINGYKNKKFNKNNKNKPCDHCGRRNHERKDCYFLKNNTTGEDNQRTLHTIQMQNEEQKFTFMTADQVENKQSSDLTKVNFVIDSGATDHVLKDIDIFKTLSTLDKPIKISIAKKGEAINATKIGTIEVTTNLGVTGLLENVLYVPEASTNLLSVRRIQQAGMSIIFGESGGVMVKRGVQQKICVKLVYLENKHGCLSQKKETEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFK4</accession>
    <name>A0A232EFK4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004981">
        <property type="protein sequence ID" value="OXU17140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFK4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="19372" checksum="D33C651160FE18BA" modified="2017-10-25" version="1">MCTMPASVNSPFDLACAVCMENWAMASLTDHDVYAKKMLFRSLDRTRFGFCGIVYVLLSVVYNLLGRRVAIYNYYAILLWHYFLRRMCQEYPYSVRVNQFPKYPPVSFGLGVSYLKYRVVVIDHLLFPDATFRVEILVWNGLVAENYLLYYHLACYFILVVTDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFS8</accession>
    <name>A0A232EFS8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA (cytosine-5)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_005290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01004941">
        <property type="protein sequence ID" value="OXU17206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EFS8"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.120.10:FF:000001">
        <property type="entry name" value="DNA (cytosine-5)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022702">
        <property type="entry name" value="Cytosine_MeTrfase1_RFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12047">
        <property type="entry name" value="DNMT1-RFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037404">
        <property type="entry name" value="DNMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="848"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="1060"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="348"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 11">
        <location>
            <position position="1290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037404-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU17206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1659" mass="188492" checksum="45841624D90A51DB" modified="2017-10-25" version="1">MSESTNNTTKEEKDPVEKDEAKPGGSRDDAKEKTSSRKRKASTSDEVKAKLKVKISSKKKKVKKSSKVKKSSKDKSPKEKKKTGSRSKDARTEPPVEVPQDASVAVHNKLLPPEVLICTTAEVHNEMNSAEILTGANIEICNDLPVEVAQLEETCVYEAQEPLQSIDNEDDKKEDQDFDSKSCNVTLDEKSMIDTQNRSNEFLLGFNSKLKPEFTMTDPETKEVREDQDETVDICENASNCTKDDLNSEKIMIEVQDTIIDEALLDFNNKQELQLAVLATETVNANPVELNQQKDVEVGKDDDEAMDTCEDFNKDLLKENIEASENEEIDVCGDNNDAEEVHHAMELTEVNADSSNKHTDEARKEQNKIVDSCKHEQNQESKSLKIKTLKSKTPKSSKQSSSKSSKSRDRKKSKNKSKKDSTTVTTSPDPHYKVNKQDDISCRICEQTLNYQLKFYTGEPENGYDEELAIIDSRLLLFNGDEENISREDTRAYNKITSFSVYCNNGHLCPFDSGLIERDVEIFFSGYVKPIYSDDPSIENGVPGKNFGPIVEWWSTGFDIGEQPTVAISTEIGDYILMEPSDEYKPFMHSVLIKILIGKIVIEYLVYEPHATYEDLLNKLQSASSKYDILPNMTEDVLLEYAPFICLQVMSYDETAKLNEPLMLVAPCIRRLVDLAGISFKVNRGVSSRGQFHKYQERRAGEYRKELLRKVAENRGDNSTTSQLIDSLLPNVEEKLITLSKPCSRDPCGTCDRCQRSSCKECEPCSQKNYEDCPRRRCFYREIQEANDEDAKDSVNLSQLKGNSSISVFKNTINIFSSFNAKLEWLGDPLMVEGSGNTFYAAVKHEEETVSVGDFVLVRSVDQSVPAQVVKVAYMWEDNVGLAHFHVNLYWWGKDTVLGELARPNELFSINKCNNMSVNCITERINIDERYMPRKQDVRTDEDIKAKIFCEKSYDPSDGSFHDLTKPEVVSVLPAHRSCINCEGKHRRSERVEPRTVDELGKKEEGTFYRAVIYKDEEYIVGSCVYLKPKSLYFQFPMLLDHAKSSRKISKKIDEEKYPELYRKAEDAVIDSKFDMPAPFDIGYITEIFTTDKLYIKVKKLYRPENTHRNEVLIKQNDMNMLYWSNEVCTVSFNYVVRKCYVAHIKDFSKSVEEWSNLGPDRFYFMQMYHDKKFTDIERNMYGCEDVPLDPPIDYPDVDAMTSLEIFAGCGGLSLGLRESGVIKKLGSWAIESDVDAANTFQLNNPDITVLVEHPDIVLKNVMKGEFEDSDGKLLPRKDNVEFLCATLPCENYKTMSDITVFKHSYIATFLSYCDYYKPLLFILETDEKLIKRSFVLKLTLSCLVSMGYQVTFDLMQVGCYGAPQNRRRSVLLGAAPGSMLPKFPERLHVFPKPLCELGIVIDSKKYTQDTFWTESAPYRSVTVQDALKDLPTTKVGITEEMSYDAKSTSLYSKIMRLNMLEPTVFNHVCKDLGPLVECRISQIPLSIGSDWRNLPNIEMQLKDESCAKKLIYNYDDVEAGKSSNGKLRGVCSCASGERCDPRDRQHGCLIPWHLVHSARNNKHWAGIYSRLQWDGFFNGAITNPQPLGTQGPVLHPTQPRVVSVRECARAQGFPDEFALPQKIGIHDMYRIIGQASSPFLGRAIGHDIARSLASRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG00</accession>
    <name>A0A232EG00_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004906">
        <property type="protein sequence ID" value="OXU17264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG00"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="118" mass="13435" checksum="5CFD0035B0069EF5" modified="2017-10-25" version="1">MQERDLEAGIQRLEQAPATATADPNRAMASCLGAVFGLIVVLVLIIVKSQEESEKMREEALHRTEQKVMKRSFYDHQSWISKSSYIIKETATTTEKQLEFQALILPGRIFCTFNMNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGA6</accession>
    <name>A0A232EGA6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_007382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004803">
        <property type="protein sequence ID" value="OXU17390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGA6"/>
    <dbReference type="SMR" id="A0A232EGA6"/>
    <dbReference type="STRING" id="543379.A0A232EGA6"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU17390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="16045" checksum="3ADE0E6274CEAA9F" modified="2017-10-25" version="1">MSIRPVYRPKIVKKRTKKFIRHQSDRYDKLKRNWRKPKGIDNRVRRRFKGQYLMPNIGYGSNQKTRHMLPTGFRKVLVHNVKELEVLMMQNRKFCAEIAHGVSSKKRKTIVERAQQLSIRVTNANARLRSEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGA8</accession>
    <name>A0A232EGA8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004807">
        <property type="protein sequence ID" value="OXU17383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGA8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="136" mass="15111" checksum="AFCEA8E422B1D14B" modified="2017-10-25" version="1">MKHDGIRGGDMGVQEQRRTTEDLQKIFEVGLKTGQDNIGAHLETKQFKLEAKTRTTLLASEPQYCSSTARWPHTTHANMNSQALCRSILSASKSTEEEVEKTSEETFEDQLMTTSCKACTKIIGKGKSHKTCDKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGI6</accession>
    <name>A0A232EGI6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004750">
        <property type="protein sequence ID" value="OXU17470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGI6"/>
    <dbReference type="OrthoDB" id="6119432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="9690" checksum="E1832A6C781F90B7" modified="2017-10-25" version="1">MTDELRSYGEGTSIETMMSVAPKFYAFRAITPDTCATIECSKINFDSIKSLIDDEFGENADKSDNDTVKDKRTIKATILANRTLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH22</accession>
    <name>A0A232EH22_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Activin types I and II receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004646">
        <property type="protein sequence ID" value="OXU17612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH22"/>
    <dbReference type="STRING" id="543379.A0A232EH22"/>
    <dbReference type="OrthoDB" id="7632606at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Activin types I and II receptor" evidence="5">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU17612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="91" mass="10193" checksum="BE2160F9A5FFF087" modified="2017-10-25" version="1" fragment="single">VRTATADVGGGGGEGREGRKRTERETFFEVRNSRLKCHCDICSETNNTCETDGYCFASTNLDKDGITYAYSFMDYRCTPLKIIPKHTASMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH30</accession>
    <name>A0A232EH30_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004616">
        <property type="protein sequence ID" value="OXU17655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH30"/>
    <dbReference type="OrthoDB" id="7530072at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU17655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12854" checksum="75D32A055691E02E" modified="2017-10-25" version="1" fragment="single">MYHFFLYSMVLSGLSIFAIDIILNRDDYFILLKLVPCLAAAIVYIFYFNWPGQKIIEINDEIFTTIYLTNWYSFPLQTQKLMKFMFLRSADHIFIKASIFEMSFKTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHJ8</accession>
    <name>A0A232EHJ8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004495">
        <property type="protein sequence ID" value="OXU17814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHJ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8830" checksum="4FEA7DE1E51F777D" modified="2017-10-25" version="1" fragment="single">YQHHQTALIQLQSYLELFKVANNAKPHCHASANQLQGSPWMVELAAINSKLSLSFDSNVTYLATRNIRITTLIRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHT6</accession>
    <name>A0A232EHT6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004432">
        <property type="protein sequence ID" value="OXU17905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHT6"/>
    <dbReference type="STRING" id="543379.A0A232EHT6"/>
    <dbReference type="OrthoDB" id="7617425at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="332" mass="37106" checksum="F7BB0C96B7AD580F" modified="2017-10-25" version="1">MENTAPHTPQQKGRAERANRTIFESARTILRAKELPKWLWAEAVNTAVYMLNRTTHSKREGVKTVFQLWTGRKPNLRHVRVFGSTAYVHVPKQFRRKLDDKARKAILVGYQDESSNYRLYDAEKKTIVVSRDVVFDEKSTDECTNEREPEDDAPFRLKIERKNEVVAIPDESDEEADQEAEREVVDEEAPACHGSSYGLRLSHVLSQSDGQSQGLGLSLSHSLGLCHGLGLCHGLGLCHGLGLSPGLGLSHGLGLSHGQRVSHSIGQARGHSQGQGLSQVYSLGQCRDLGRGHQFIRNPVLPLFPVTVLMLTITLKDRRPLRKEIDLDLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIB9</accession>
    <name>A0A232EIB9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004293">
        <property type="protein sequence ID" value="OXU18096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIB9"/>
    <dbReference type="STRING" id="543379.A0A232EIB9"/>
    <dbReference type="OrthoDB" id="7699079at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="337" mass="37392" checksum="7C22341DED0F4F88" modified="2017-10-25" version="1">MLNMNHFKEEFSYLLLRYASAEATNNNNVPENCTPLTNLQILDGVKEVLRKTLSIDLQHVEPSTMKTPVNEIVVTTPDAPDVLRMDYNQTNVLHNKFKSLDSATEEKNSFDFDNFKSTSFIHTPTEIGTPSIDKPFLELGINKNLESLEQKFKEIPKFDTAKNMTMYSMVEDAHKDVMKVVHKLEDLRELLLPEARPIRRLSAIMNLPKSQQQQSSSSASNNLRTTQRAKALTRRSMGQLNEELSVTPTSSRPSLVMPPSSLQGKKASAGTGVTPKPLSKLSQQTRSVSTLSLLTDTNKSAGSGASTSKSPSKKNSKYAHVQSTIPKPTSSAVKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIC6</accession>
    <name>A0A232EIC6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004773</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01004284">
        <property type="protein sequence ID" value="OXU18106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIC6"/>
    <dbReference type="STRING" id="543379.A0A232EIC6"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:follicle cell of egg chamber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06618">
        <property type="entry name" value="PKc_MKK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000432">
        <property type="entry name" value="mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052468">
        <property type="entry name" value="Dual_spec_MAPK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238:SF2">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="119"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU18106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="410" mass="46832" checksum="76E2A5B27AA6938A" modified="2017-10-25" version="1">MSSTLENQILNLQERLRAENQLRDKDKQQQQQSSEMQQQQQQPPNMPSPCLSPAPARPRQLGDMGTPTRPRRQLDLPVSHMMPFKRHDGEVESKMQEIMKMNGILNINGQKYHTEMKDLEHLGELGNGTCGHVVKMRHKPSGVVIAVKQMRRSGNTDENKRIIMDLDVVLKSHDCPYIVQCLGCFITESDVWICMELMVTCLDKLLKRSRQAIPEDFLGKVTVATVKALSYLKEKHGVIHRDVKPSNILLDETGGVKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGITLVELATGVFPYRDCKTDFEVLSRVVQDDPPSLPSDALFSKEFQNFVSCCLTKNYKQRPKYNKLMEHPFIRKYELQQETYSSTPSSGCQWFYRIMRQLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIM2</accession>
    <name>A0A232EIM2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004202">
        <property type="protein sequence ID" value="OXU18203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIM2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="112" mass="12558" checksum="E66921A4B7D36F9F" modified="2017-10-25" version="1">MHNYRSVIPAAAKTEQNEDSTISQHAWAEPNNLLVGMDDSFCKNDSPAISVSADILLIKNAPIALANSDETDACDKKTRKRQAESEPEVPKKKYRITVNGSVQWFSKQDFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJL2</accession>
    <name>A0A232EJL2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_008561</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01004003">
        <property type="protein sequence ID" value="OXU18512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJL2"/>
    <dbReference type="STRING" id="543379.A0A232EJL2"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="66"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU18512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="500" mass="58468" checksum="22E7BE03F77A756B" modified="2017-10-25" version="1">MGKLDVKMMRYLTKEDFRVLTAIEMGMKNHELVSMTLAAQIANLHHGGLHKILKELCKHRLLMYEATKQYQGYRLTNLGYDYLALKTLTARGLIDSFGNQIGVGKESNIYVVQKKDEEIPYCLKLHRLGRTCFRKVKNKRDYHQHRKHMSWLYLSRVSATKEFAYMTALYDRGFPVPKPIDFNRHCIIMELVDGIPLCNVREVENKERLYNDLMNLICRLALHGVIHGDFNEFNIMITHDEKPILIDFPQMISIEHEEAEVYFERDVFCIREFFRRRFDYESSMYPIFKNIVNNDAEQAKKHPKVELHSPTVSDAEDYDVDDEEEDEEDPEEAREKLAQLEIEVKPNLNSTINAYLNTCDYSHEQEEAADTETVLPENQDSESNKQEVEKKVLFPEPAVATNEDNVESSETNQESEVHDEVPELVQVSAEQQNDTDSNYDVRSTASTIIPEDQIKRRMKMELVRREKKAVNKRNLKKSTKATRSRRENLDIAKENVDFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJL6</accession>
    <name>A0A232EJL6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003969">
        <property type="protein sequence ID" value="OXU18560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJL6"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="13903" checksum="765F6179D0A0626B" modified="2017-10-25" version="1" fragment="single">QLEDVKCQYNSNEINWIVIELHGILKPYFESINNCDIGHVIFKRKNSVELIIDDHILEGKNITLEKPIIVLRKNYNSDHKSLFYSLERRTRTHVSKHRSRYPEPESNRNMRVAMPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKB8</accession>
    <name>A0A232EKB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="13">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_013521</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54232"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:54233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74963"/>
            <dbReference type="ChEBI" id="CHEBI:82949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:54333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:54245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:32940"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01003825">
        <property type="protein sequence ID" value="OXU18793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKB8"/>
    <dbReference type="STRING" id="543379.A0A232EKB8"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU18793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="533" mass="59304" checksum="C84A71F699E6D796" modified="2017-10-25" version="1">MQFFHKDKILSPGQLKRLSEHKYSCSSASLLDGFLQPWWDWLVSKVPIWLAPNLITVLGLIVNIVTTLVLVWYSPDAKAEPPRWACFLCAVGLFFYQSLDAIDGKQARRTGTSTPLGELFDHGCDSISTVFVALSACIAVQLGYYPTWMFFQCFCAMTLFYCAHWQTYVSGSLRFGKVDVTEAQFTIIAIHLISSIFGPGIWMKEVIPFLDGFQFKYLIGVMTVVCALANLYTIFSVIFTGGVGKNGSTVAIPVPNMGTYSNLVAVTFYAGYVNVFIQFCKVFESGGVGKNGSTIALPYTGTEVKIFPLWGAVGVAVLLALSSMSVILAGGVGKNGSTVAGTSVLSPIIPFSFVVVPAFIIYRKSAEHVYENHPALYILAFGMVAAKVTNRLVVAHMTKNEMQYLDSSLIGPAMLFLNQYFNFFIKEYYVLWLCFIWVTLDLLRYSAQVCTEICDHLNIQLFRIPYADHHHLHQNQRNSGAQGVTEKNGTTITTRSQMQMPVEAEPLLYEESVVQPQLHHHYHHHGSNTSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKG7</accession>
    <name>A0A232EKG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5'-deoxynucleotidase HDDC2</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">HD domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_014447</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01003794">
        <property type="protein sequence ID" value="OXU18856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKG7"/>
    <dbReference type="STRING" id="543379.A0A232EKG7"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="14">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00015933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU18856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="195" mass="22655" checksum="36C401D42A17E412" modified="2017-10-25" version="1">MNSKMDVKKMMEFMELIGRLKHLKRTGWVIRNVPDPETISGHMYRMAMLSFLVDPKENLDKSKLIEMALVHDLAECIVGDITPHCGVSTEDKHRMEDEAMEKICKNLGDRGAEMLKLFREYEKQESAEARYVKDLDRIDLLMQAFEYEKRDNSPGHLQEFFTNTQEKIEDPFLGDIVREINSQREALSKTLANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELM9</accession>
    <name>A0A232ELM9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003526">
        <property type="protein sequence ID" value="OXU19255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELM9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="115" mass="13003" checksum="CDC6B7229BDC9594" modified="2017-10-25" version="1">MFLRIPAWISEGGPLDQPESGLSLKTKQRKIGIAMDFGWTMIPHQTETQQLGNDHESPLDNEARLHKFQEESSANIDKSGARGIISVTVSDKRRMSPPCILHRLEIKNYTFLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELX1</accession>
    <name>A0A232ELX1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein maroon-like</fullName>
            <shortName evidence="4">Ma-l</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mal</name>
        <name evidence="6" type="ORF">TSAR_003916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01003469">
        <property type="protein sequence ID" value="OXU19355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELX1"/>
    <dbReference type="STRING" id="543379.A0A232ELX1"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="5">
        <location>
            <begin position="674"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="817" mass="92399" checksum="C8381048AE227CEA" modified="2017-10-25" version="1">MDELQYSPVYDEKTQQVLEREFSRIQGECYVDHAGATLYSDNQIKKSLDDLMLSLYTNPHSNGVNGNVTEEIVDNIRYTILDHFHTTQDEYSVIFTSGATAALKTVAETFNFKNVDNKSDEKTGTFVYLQDNHTSVLGMRELIAHRGAKVTCLKNENAFEVLQEYDDKNIGMQNEKPNSLFVYSAQCNFSGFKYPLSWIKNVKNGCLNSYTKSETNWFTLLDAACFAGTNDLNLSIYKPDFVCLSFYKLFGYPTGVGALIVRNDSAYVLKKMYYGGGTVDVVLSSKMFHVKRESLHQRFEDGTVSFLTIVSLQHGYKILADIRMNRISAHVFSLAKFLHHSLLTLHHENGAPVVKLYSDSDYEDRSLQGGIVSFNVLRANGEYVGYMEVLNMAALYKIHLRTGCFCNPGACQRFLILSDEEVLKNYDTGYTCGGTKDLIDGKPIGAVRISFGYMSTIRDVETVLLMLKKCFVSGKPVIKLPLWWSDFKTKLNEKYKINDSKSVNGTQNNLKNNIVKMSNRITLLEQVSFSVKNNNNIAQNGQKRPLKLAKIFVYPVKSCGAYEVEREWILTSKGLQFDREWMIVTSAGVCLTQKQETKLCLIIPVIDFKNNELQLSYPGMPSIGVPLYFSANEINSSKICRGKVCGHKVEGADCGAEVSEWLSLALGRPNLKLIRQSDSTKENTTNKPALSFASQSQYLLINVASTDWLADRVPEDSQCDRDTMLYRFRGNFYVEGCAPFEETRWKTVQIGNCYFKVEAVCTRCQMICIDQTTGKKTVEPLRTLAEEFHGKLKFGIYLVKQNEGNDTLSIGNKIYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM34</accession>
    <name>A0A232EM34_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003437">
        <property type="protein sequence ID" value="OXU19419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM34"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9773" checksum="4CAE34CD10F15EB1" modified="2017-10-25" version="1" fragment="single">LRSSLRTVPNYQEGKKIVKPSNSSDILGARTKLLTHLSRGHDLRNFLRGMYRFSHVLRQRRSCCLFTFGPGLVFQREPSKIENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM84</accession>
    <name>A0A232EM84_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit beta type-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003417">
        <property type="protein sequence ID" value="OXU19447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM84"/>
    <dbReference type="STRING" id="543379.A0A232EM84"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="449" mass="50354" checksum="C39BA01B2F3F1D14" modified="2017-10-25" version="1">MTEADTVISLVPVVDYSLDDSSAESSSFVLRFCCSVRLPGSKELYFLGVRFPFHQESPLQRGDVYVDQMLADPLIGRRSRQRFCYSVRLPGSKEVYFLGVRFPFHQESPLQRGDVHVDQMLADPLICRRSRQGRPMADFRGRSGLCLPLEKLQETDRFVQIGGQAETDKTRQARLALATAWWSARWRVGSLVVPGGGDPHISRCPLKLAFDPSTAQQFSGGGRTVDPPLDLTPWSMLSSVFYRKLSILAYNGGAIIAMKGKNCVAIAADRRFGIQAQTISCNFQKIYEMGPHLYLGLPGLATDSQTVMERLRFRLNLYELKESRKIHPKTFGSMISNLLYERRFGPYFVEPIVAGLDPETFEPFICNMDLIGCLNLPEDFVVGGTCSEQLYGMCEALYEPNLDADDLFETISQALVNACDRDAISGWGAIVHIIEKDKVATRTIKTRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP85</accession>
    <name>A0A232EP85_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002990">
        <property type="protein sequence ID" value="OXU20164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP85"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624333" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="120" mass="13357" checksum="A3826466CE4E7965" modified="2017-10-25" version="1">MAFRDFFLLSFLALAVSTQECFAYVAKSRDVARTDESSVPHAFVTLGASKLIMAFRDFFLLFFLAIAVSTQECFAFVPHSLNTRAISQSDVAPANSKAHHAFILLGASNYYFCVNSSYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPH5</accession>
    <name>A0A232EPH5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002943">
        <property type="protein sequence ID" value="OXU20254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPH5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="1">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="149" mass="16598" checksum="EA89F95696C5FFC1" modified="2017-10-25" version="1">MTNTRNSGTTTLTTGMTTRTATTAMTKAAVSTNIMQTLMEVCKLGFRAAMLIPNEPKLWFTQCEQNLANTGITTETTKFSYLGGNIDRKHAIFVKVNFYLDLLPHAARMQAAMNELLKGNIKGNQPISWLPLMLPRRPRPTSSEPYNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPJ4</accession>
    <name>A0A232EPJ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002937">
        <property type="protein sequence ID" value="OXU20261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPJ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="46" mass="5309" checksum="6ABE83E3C0AEB8B4" modified="2017-10-25" version="1" fragment="single">YLSLLTARIFPSRPHHITFHFIAHSISHTSITLTKLKTLYTAITKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ12</accession>
    <name>A0A232EQ12_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002841">
        <property type="protein sequence ID" value="OXU20455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ12"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="148" mass="16909" checksum="C7262660379DDC4B" modified="2017-10-25" version="1">MTSKTSVASTSPISRLATNVQSKMHIKTPSPTNSRVQRKIKRRLNQICNQMSEMKLSSPPQPQQLQEQQQQQQDQQEHNMDQEELERFCQASTVKKGSKRAIEEPESLAPRNILAESRLSPSARGRSFHAVSRTYSTHRAEKLTDSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQN4</accession>
    <name>A0A232EQN4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002741">
        <property type="protein sequence ID" value="OXU20651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQN4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="14803" checksum="05215C8B63763D59" modified="2017-10-25" version="1">MKEDVLKNIQNEIAENYNQHFTGTEIQQKFKYLPDIFVKSDLKIQNKEHVTYMEKFMYQRLFFLKPHIIHKRGNEVSKYKTMSSIKCTESAFDTTLNEKKGYLLNIKDNEILKKDSSSVESVSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQQ1</accession>
    <name>A0A232EQQ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_003361</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002732">
        <property type="protein sequence ID" value="OXU20671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQQ1"/>
    <dbReference type="STRING" id="543379.A0A232EQQ1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001228">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU20671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="657" mass="75073" checksum="3BB9131D9FDCC4AF" modified="2017-10-25" version="1" fragment="single">PTDSDKFKQVQSLQLLLSVSLQEQNLAISHDHPDRHHHHLYGIRLSSSELRLWLVDEDLIGTIIVLNDTRTEILKVENTYLPQDGMTEVVVADLLGKNDTDGSFIIPEIIDADEVLAQNGQIIQIIGDYECVTCHRIFPSEDMLKEHLQVCREEDDDADILELGRMDDIESEEEDEDDDGQVDDPDYNADSSLSDSHSSKNNNKKVPIKPVSEGQCHCCAEDLKTAHSGGSFKCTHCDMSFKKSFSLERHLVVIHWESDSCTCNDCGSTFRDKKALDKHRYTTHIKTNKVYKCDKCDTYFSRSYHLNRHKQQSGCHGDTTNSFSCQVCNKVFTQNTYELMLECHKERKNHCQKKFAARETLNRHQRTHTGEKPHVCQYCNKSFIQAAQLRAHIFHHTGENGFYCDICGKAFNRKARLTNHKKFVHEGATPFKCETCDKAFTRKEDLSKHINLHAGIKPHKCDTCGKCFAAKSSLQAHMNTHRREPPQSCAECGRAFIRQDCLMRHIRAKHRDLLEDVLGEAEKKHLQLQMFNIAYIAAEKMKTGETNILSTEELMKAITELLTILIEKETLELFGWLQSPLQDVLEAVIRRCGHEPLTADSDLSLPDRLRGNVKLLFNAVIEDENVKSLLTTQTVDEVIMHVLKISQTNNKEAEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQW9</accession>
    <name>A0A232EQW9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_005269</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002685">
        <property type="protein sequence ID" value="OXU20779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQW9"/>
    <dbReference type="STRING" id="543379.A0A232EQW9"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU20779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58274" checksum="63C5426AA658A406" modified="2017-10-25" version="1">MMESCPGCDLLPWLVLPGLLVFLGYWYLTQNHQHWKKQNVPSLPDPLPIFGHMLPVITLRDNIGTFAERLHWYNKDASMLGFHFMGQPALLVREAELVKIVLQANFSSFRSNLLQLSERNDPVLSKNPFFINEPGRWKETRMRIGSHLTGTKLGRLFVIVDQVVRQMKSFTDRRIGSNGFYECELKGYFVRCTGEVVANAAFAIHGQSFEDQPERLSFYEMAKTIFEPTTINGIKQALLFYLPAFGELLGVSFLQKSTDAFFRENVTAIIKQRREQNASEPPSDFLQYCIDAAPEQDIDAIVADVIIFYMDMYETSSTSLASIFYQLSRHPDIQAKLREHVTEVVQSEGDGRVTYESLKRMTYLDQVINEALRILSPLGALTKLCSEPIRLTGSDGITCELRPGDPVFVSIQALHLDEKYWPDPERFDPDRFAAENEAQRNKMAFLVFGEGPRMCVGMRLGLMVVKMTIANLLMNYQVEASPKTKLPLEIDPTSIVSNVKGGLWARFQKLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERS2</accession>
    <name>A0A232ERS2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002585">
        <property type="protein sequence ID" value="OXU20986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERS2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="212" mass="23959" checksum="9284CCEC667E4752" modified="2017-10-25" version="1" fragment="single">MGSGGVFSTTKGAFSGVGESHNSREYAATDALVVGAVCFVVFLNIRDCAKSGDGVTSAVVCGLSPAQTAFFIVCQKCSINRQDFKFEVFVIIVRTLIDKAFVRRMLSFQHFGYDIPLRNSGRQRHNQPQEFMKTFNNKSYKTREDEGSPGVEDRRRRYQVTGDLVYLGEGLSVTSVGFNYMCKQPIKQFLRWLALKIWEHETLMNRALQIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERY3</accession>
    <name>A0A232ERY3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002534">
        <property type="protein sequence ID" value="OXU21120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERY3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="9197" checksum="6B1B1F6F307E1ABE" modified="2017-10-25" version="1">MPDDIHTVLNTVEDNLNKGFIENEESQFIGNINEAPENYKKPVEADYIIQDYSTISKTLKDNGNYENEEKYVQHIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESE7</accession>
    <name>A0A232ESE7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002477">
        <property type="protein sequence ID" value="OXU21216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESE7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="13794" checksum="A52984EECF433049" modified="2017-10-25" version="1">MPIAYLHRVLKHSERREGVLVPWRERERGSLFFHRVPKHSERRGVVLVCLRFERGSLLFHRVPNHSERRGGVLVCLCFGMPIAYLLMLMQMHLLYGLGYFIFIDECFKLTSLNLSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESG9</accession>
    <name>A0A232ESG9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_001511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002421">
        <property type="protein sequence ID" value="OXU21309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESG9"/>
    <dbReference type="STRING" id="543379.A0A232ESG9"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU21309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28710" checksum="864B2690291D2EB3" modified="2017-10-25" version="1">MSGFSQQDNYWTPPPQNQYNFDNSGFGQPNQQFDFRNYTDQQSGEYAPYSQQEYLNPNQTAYTGELYTPDNYNQGSNTFTDEEDEPPLLEELGIDPDRILQKTLAVLNPFHRRGQTDDANYLLQDSDLAGPLAFCLLLAAFLLLAGSKAHFGYVYGLAFTSCILMYILQSLMSSTGNITIASVASVLGYCILPVVGLAGLGIFTSLRGPVGLILASLAVAWATLSSSRLFCAMSGEEKQRFLIAYPCLLLYGVFTLIVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET34</accession>
    <name>A0A232ET34_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_015415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002336">
        <property type="protein sequence ID" value="OXU21520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET34"/>
    <dbReference type="STRING" id="543379.A0A232ET34"/>
    <dbReference type="OrthoDB" id="6022628at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000094">
        <property type="entry name" value="Blast:Carbohydrate-responsive element-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="897"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="840"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="948"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="885"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122950" checksum="DA7A3B18106D4170" modified="2017-10-25" version="1">MRIPWDGLEQKPRRKVQTMAELMYRKSTPMATSSAHQELAMATSSSSHRHKRESRDSRETIHSGHFMVSDFEAEAQDDEDELAVPVPDEEAARLAIIAPPGFSLERFVSCSSADKSSQQLSIETSLNKLFQCMSLAYRQKLTSPKWNRFKGIRLRWKDKIRLNNVIWRCWHMQFILKQNTLVCQFASPLDVDTHNKPEAVVLEGKYWKRKLAAVTAEYKKWRMFYRNKILGWTNKDGSDMLESMDTLEWGGGMGNSGMFGIGAGSSFSGGSGMVSGDGVHSMMVDEDYMELMTDTLFSTISSNQPLYFPDPREIARGASLADFIQPSLGPLQPNLDDFIDTLEPLQEFLSSRLPPVPEEDVFHGSALNSSGYPELDLMAPMNQVSGMSDSSPAAVLPPPQQSSTGGQTSMQTEEPSITLQHLQYTAKIYTQAQQQQAQQQQQEAAAAAAAAGVFRNNVGVNENFNSLQQSYEQQMQQQQQQQSAQPVRDKQPRQSRAALRSSRLAQQQQQQQQQQQQNYQVAAQQQHLAYQQQQPQRNYAMEIQSTPLSTAPGQMQLSLVDQANQHVQALINQQQQQQQQQQQQQQSFAQAEAQQQQSQQIQKQLKTNMSSKPYNKISSQGYKFPPPTQNFDTQQCKFTSNNLKTLPAPPVVAVTSQQPVQSHVLLQCKPQGIDLTAPALHPTKLLPRPAASAPVEVKEEVFAVPKYQMKVRNRSRSSSSLTAPRMHPPPLVSAVSDPALNLNSNVLLAHLLTNNSSNLYTVSAGPDKVASQPVVGVKHILPMLPSTMAAGAQVTNTTHHITTPVTVQSMHTAASAQSQGQQQQMQTSVTGQAMLLNTNSQASQSSNPNSPKDGSTAHSPQGLSLSPLHSPMSIGSPLSPGRVYVKGEPERGHYKEQRRVGHIHAEQKRRYNIKNGFDMLFSLIPQLSQNPNTKMSKAAMLQKGADYIRLLRSERHQLKDEMDQLRSQIDSLNADISNCQAMLPATGAPVSRQRTNKMKEMFDEYVRTRTRDNWKFWIFSVLLEPLMVSFNTSVSTASIEDLYRTTILWVEQHCSLVDLRPAVLNSLRYLCTATDILNDPTRLPGEALAAVNQSERRKSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETQ5</accession>
    <name>A0A232ETQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002246">
        <property type="protein sequence ID" value="OXU21732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETQ5"/>
    <dbReference type="STRING" id="543379.A0A232ETQ5"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000354">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000008">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="199"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="441" mass="49728" checksum="38A9039741C0C3B9" modified="2017-10-25" version="1">MATVLEQFVNNVRTLSSEGNFRELTNALNKFSEALSRNVQHLDNVLETLDLQNHSLGILAVLCAKITSFNGGNGASGSFKPLFNQVQEFIVGCNGEQVRFAPMMYAELCHQFTDALVEQHKPMRGIDLLCRAIRKIQLFDSQLTSVHSDLCKLCLLAKCFKPALEFLDIDITGISVEDDTKSFLLYFYYGGMIYTALKNYDRALYFFEVCVMTPAAAVSHIMLEAYKKFILVSLILNGKILLLPNYTSNLVKRHIKRLSAPYQELATAYGTHSCEEVEDIILKYNDVYTRDNNTGLVQQVLSFLYKKNIQRLTNTFLTLSLTDVAARVKLPGPADAEKYILNMIEDGEIFATINQKDGMVIFHDDPEKYDSPRMLAKLEKEMAECAELGRKVIEMEEEVIVTPQYVRKALGQNDQDDQAAGPPPSNVSNTQSQPRNNTYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUL7</accession>
    <name>A0A232EUL7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sensory neuron membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_003227</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002110">
        <property type="protein sequence ID" value="OXU22050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUL7"/>
    <dbReference type="STRING" id="543379.A0A232EUL7"/>
    <dbReference type="OrthoDB" id="10024078at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF69">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU22050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="62021" checksum="F5FBED0ECF14D40C" modified="2017-10-25" version="1">MRNTRKVLNDIVEEDKPRNDMALTKIQKIGVGGICMFIFSFLFSGVILPPIVKHEVKKKVALKQGWMMREVWGKFPFSFEFHFYMFNVTNHMDIKGGAKPIVAEVGPFVYEEWQEKVNQVDHDEDDTISYNAKSTFIFNAEKSKGLTGEEEVIMPHFFILGTVNAVLRDKASAMPIVSKALDSIFRKPDSIFVKAKVREILFDGLVIDCNVKDFAGSAVCNEIAQNYEEFRLQPIGDNKYSLSLFGLINGTENKARHRVKRGLKNIMEVGKVVEYDGKNNVSVWDNEICDAFNGTDGSVFHPYFDKKGKDDLVAFNAGLCRSVICHYDSDTKFAGLKLLRYTTDLGTDVDKYPHHKCYCVTPDRCPKKGAMDIFKCVNAPIMITNPHFYLADPWYVSAIEGVKPDREKHMIMIDIDPFTGSPIHVHTRAQFNMFLQPVEKFKLMKTFPNALLPLIWFDEILILPDFLLKEIKGGHRQVAMAKVFKFLMMFGGLGMAGYAGFMHYKATKGENTTEVKKVPVKSSPNGVGSGEKKINISTIQPAPLPANVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVN1</accession>
    <name>A0A232EVN1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001975">
        <property type="protein sequence ID" value="OXU22404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVN1"/>
    <dbReference type="OrthoDB" id="7536850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6517" checksum="2B287F5245BA894F" modified="2017-10-25" version="1">MAQKNQNQTKRDLRVGTWNVRSLYRAGAFKELVKEADRYSIDLVAIQNRGCQIAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVQ2</accession>
    <name>A0A232EVQ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001972">
        <property type="protein sequence ID" value="OXU22415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVQ2"/>
    <dbReference type="OrthoDB" id="10558644at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="155" mass="17811" checksum="CFEBA44357B773EB" modified="2017-10-25" version="1">MGGWTQLRDASWHRIESVFGLQRTPPIRPVVDEPPPAPRKICLGDRNQQLTRRENLRPRKLTYEPENQRRVEASHEDSGIVVWATTSSSILAEDADKENRPENGKRQPAKGRSRGKARTRDDIIPNSQNETARPGSLRYRLEQWMASLSIEHQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYF8</accession>
    <name>A0A232EYF8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein ref(2)P</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Refractory to sigma P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_001638</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for selective autophagy activation by ubiquitinated proteins. Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with aPKC and Traf6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001603">
        <property type="protein sequence ID" value="OXU23454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYF8"/>
    <dbReference type="STRING" id="543379.A0A232EYF8"/>
    <dbReference type="OrthoDB" id="441278at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06402">
        <property type="entry name" value="PB1_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14320">
        <property type="entry name" value="UBA_SQSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000320">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000016">
        <property type="entry name" value="Refractory to sigma P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000034">
        <property type="entry name" value="Sequestosome 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034866">
        <property type="entry name" value="PB1_p62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033741">
        <property type="entry name" value="SQSTM_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16577">
        <property type="entry name" value="UBA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="17">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="16">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="402"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU23454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="493" mass="55954" checksum="531D934AF91DE386" modified="2017-10-25" version="1">MAEQVHFKVFLRKNNSRNDNHAEIRRFAIDTDVVTNFTYLREKLQTVFPDLRGKRFTITWKDFENDEIVICSCEELEIALAELQKYPLCKLFVTLHSDYDDENNCPIKSPFVHFEATNNPKIKHAGIVCDGCDKSVCGFRYKCVQCSDYDLCSECEAKGLHPEHCMIRISMPLQWRSHYGRRLSHHINKFMKKASTCPSSAEEETKECPFKPRRHNLYNHRAEQSPSWIDTFTTYLNDWANLPGECPVMGEQEKSKTGTSEQNQSMANKTSSASTNENNPMDSHVQFLKNFSENISQFLDPLGIDVNVQVKADESPITEKPLEDTKLSQEYLPNLKKVVTDDDKNHKEATDELVQSAANDSQEKNKPITKINAKEGNQVTVNDATKADDWTLVDKDSVPASSEIASGKIAQNEKKPSEPTVENSKATTDDKALYPSLPNVSDNVWHPNPKIQRAVEAMMQMGFSNEGGWLTQLLISKNGDISRALDVLQPVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ56</accession>
    <name>A0A232EZ56_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable proline--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_000342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001563">
        <property type="protein sequence ID" value="OXU23589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EZ56"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000042">
        <property type="entry name" value="probable proline--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="47"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU23589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2317" mass="260929" checksum="14B79A28B9A6208A" modified="2017-10-25" version="1">MTWINRVSKLFQPSIVIPKSSLPKTDLTSKSYQLMINAGIISNVTTGMYAFLPLGLRSLQKLINLIDQEMTAIGAQKILLPVLTQSNLWQQTARLKQAQSELFMLNDRHGKEFLLSPTYEESISNMISQVGPLLRKQLPLRLYQTSSKWRDEIKPRLGLLRSREFIMKDLYTFDLDADSAKCTYEEVSDAYKKIFERIGIPYKKVIADTGIIGGSISHEYHYVSDIGEDVILSCKSCKNEVDKVGEPKTHCPKCEEPLISTNSVEVGHTFLLGTKYSKPLKATFIDSNCKKQFLEMGCYGLGLTRILATAIEILSTNLEIRWPLELAPHSICVIPPKKGSKEEAKAQLAYDVYSRIQNCNLDVIFDDRVDMTIGKRFIDARKTGYPVVIIIGKNCLADEPLVEVHNVYKASHVNLALENVVEHVQNIANLDEIKDIMINASDPLEYIPSGRVTVSKHPEFQTNEVHEDSNLYQSTISEKLNNVNAGSKPSKDFWILRDTKNDQEEELYCSGKLAVYSKGCQVEDSLQTSFCCETNIVHATWCKFYVEDKDQIMKCKIGNLQKFYKTAVDCVCLVDSYTLKVFTEFGENYSSSLQFKVSAVWSTKYGILLERSIQPAAPYSSFSKLTLDNTKNVSTTEEPHTPTVYSLTHPLDDICPVLIKYGTSSSPFRSRAASCTTTGSANISLSSQHLSRSHSPMATISRCQSPTNPIFSTMNNSSGGYFGHHSRSSYQTLLALSAGQSDRNAGHYNRPTNQYLNNSPMGATVPELCLEHIWTENPALIKDNNADHASRVFLTTDLIGQTYLCYLIQNQHRLYLVRLEKSNEPNQIIMGMVNTITAKDAISLPKLNMMAVMESNGNIIIYSGTSFIGKLHIPNVVPNIVGNNYVLSSVYGRDFLSPYPRRSSLISPNRQSTPDVKFDEGVHLLSPVGGGAYTQLDMIDNSLFDGGPVQLKSAVSNKLILEYGDSNYVKMTLPTLKGSPLVLMCLQTLKNILPRDLGMQLLVKWYVARNAPGPEDLSINQEWNLFLNIFFTLFGYDINKLHINMNNDLDPASEHYSPIILSKKQKTINNGSNDDWSYLVASEVTSHVQTFLYDAIGLHKWKHKENNDTVDVMESENIKLNKVNIQSQFAAHLPHILFSLHLLYEELKLSSIMSESLFLLSKLLYQLSMDLNLHAYRQHYFSDFPVLSKNQTEFLVNDADTNKIAIPTFISADTPSIFKNLYNLLTFSNVSSYPYLVQVNPTSRNLIQLFAMLKRQKDIKILELDHFFKTISSVTNEAEYVSEKRINKQQLEDMPLGLRFIFSNVIHQCREDPPTNWPASVYELIDRQDLAVLQKKIFDSYYLDSTQDKIVKNNSDDVEHNDGMEFDYTILRLRFNLDHRVREVRKLLDSSEPVRIAIIQRPDVSDHEFIVEQEKFLHALCTRTMALPIARGMFTLRTSMPMNTEQLPIPKLCLTGKAPPRGTTVELTHIDVPANMNLWPLFHNGVATGLCIHPSAQNVDSTWIVYNKQQQGEFGIEHSGFLMALGLNGHLKNLAPFSMYEYLVECHESTSVGLLLGLSATHRSSMDVAMTKLLSLHVETLLPPTSIELNVQQNVQVAALMGVGLVYQGTNHRHIAYALLSEIGRPPGPEMKNSVDRESYSLTAGLALGLVVLSSGGGSDLASIPDTLHYYMVGGNTRPFSGAQKDKYRSPSYQIREGDSINIDVTSPGATMALGLMYLKTNNHAVAEWMAAPNTQYLLDFVRPDFLLLRILAKSLILWDEIEPSKTWVSSHVPDIVAKYKLQKPTANISEPIDLETINQAYCNIIAGACMAVGLKYAGTENMIAFNTLYHFLKMFMTLSHKSVAELAGKATIETCLNVVLLAASIVMAGTGNLDILRVCRYMRTRVGPTNSVVTYGSHVATHMALGFLFLGGGSYTLSNDPASVAALVISLFPKFPTHSNDNRYHLQALRHFYVLATEPRLLLPKDIDNKKYCYAKIRLTFQSDSQNEGQKIVLKAPCLVPQLDRLDKIELDDDRYWKITFDKDRNFDLLKEILNANCVLHVKQRAGCLSHTEDPQGFRTLLAQTLTTEDIIVWTASLKQITSFTTDTTVLNFVNGFLKKGDLNHHTICDSFCMNKMHDKLSSLCCSGIQDSSDETSNNFNNVNEIPQEISVTENHYLQILISMTYECVIKDKINFLPLWISIYKTLVTIEKEPTTNLIWQIKFLHSFKFCNNFFQGVDKLLNIENILANKQHLYLITDSWESDISIILKNLSNIGCAKTRIKAFEKLSSYILNYNVPCQIDQHVVNPPENPIQDKNTTCLTAYGAFRFNSLFGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZV0</accession>
    <name>A0A232EZV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_011869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001489">
        <property type="protein sequence ID" value="OXU23800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZV0"/>
    <dbReference type="STRING" id="543379.A0A232EZV0"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15721">
        <property type="entry name" value="FYVE_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000011">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="156"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="750"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="404"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="675"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="93339" checksum="9DD51F65E2EAD713" modified="2017-10-25" version="1">MYNKKKKLWARTLTFMRPEYPDDNLQSAAGCQKSNIKMLDQDMAGAQDTIYLCNFRVSVDGDWLCLKELQDVEFSSMPETMQRSPSPPIGLSGIQCDLQQPSHDDAPELCDILSSPIQHVSSRDPVIIERSNLVNISKLIVKELIETSLKYGRMLDSDHMPLQHFFIVLEHVLRHGLRPKKGLLGPKKELWDILQLVEKYCPEAQDMTSSIRDLPTVRTAMGRARAWLRMALMQKKLADYLKVLIDHKDDLLSEYFEPDALMMSEEAIVVMGLLVGLNVIDCNFCVKEEDLDCQQGVIDFSLYLRNSNHIPGESPDDELENDNMTTVLDQKNYIEELNRHLNATVQNLQAKVESLTTTNALMIEDLSIAKNNILSLHYENQQLKKELGIEVKDTNENGKAPIKITETTSEMEELRSRLETEKRLRSEAEKELELQISMKSEMEVAMKLLEKDIHEKQDTIISLRRQLDDIKQINLEMYKKLQECEQELTQKGEMVSRLHAKTNQIGKLLNNLEKFNHYMKDGEGGRSPTGYKAIMNRSSPTTPRDQQPPMRPRSMFDTTDTIKPQPKPATTPSGNKRITSPPESKQPWNEFQECESSLRHKTELIAKLEAKTYSMTETIQRMDEKYKAMEDVRSGVEERVRVLGAEAAEKEARATGIERELKIEREWRTSLQESSINSTEKISQLHQEIDRLRKESEKYKSLQEEHYALKEICQEQEKTLEELGGQLSAAKLAAQPHPPDGTGTATWANDRMVTQCKGCSREFNIARRKHHCRNCGNIFCNACSDNTIALPNSTKPVRVCDECHVFLVGRYSVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F021</accession>
    <name>A0A232F021_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_006700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001443">
        <property type="protein sequence ID" value="OXU23962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F021"/>
    <dbReference type="STRING" id="543379.A0A232F021"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 16" id="KW-0769">Symport</keyword>
    <keyword evidence="4 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="766"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="972"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1028"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1097"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1175"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="184"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU23962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1241" mass="139012" checksum="555B32290BD2C5C0" modified="2017-10-25" version="1">MGASKDGKHNPAFVGDDGVELDGLEATGPYTIPSSGSLPNKDEPRPPLVLASSADKTSAQSRERQTWDSSVEFLMSCIAMSVGLGNVWRFPFTAYENGGGAFLIPYIVVLFIVGKPCYYLEMIVGQFTSRSSVKMWSVAPCLRGVGWAQMFSMVAVATYYCSLMSVTMYYLIGSFQAPLPWSECLDEWADVCVDSGRRANATDHRSNRTGLRSSAELYFTKTVLKEKSSIDDGLGLPDWRLTLCLLFAWLCIFGVLIKGVQSSGKAAYFLALFPYAIMFALLARAVTLEGAANGILFFIKPDWKKLFEADVWYAAVTQCFFSLSVCFGGLITYSSYNGFRHNIYRDVMVVTTLDTMTSLVAGFTIFGILGNLAHELGTDDIGNVVRGGSGLAFVSYPDAIAKFTVLPQLFSVLFFLMLYVLGIGSGIALAGGIISIVNDQFPNWKHWHIVLATCLIGFGVGTAYCTPGGQFALGLVDYYAASFVVFVLASLEVTGVFWLYGLENFLDDVEFMLERRPSVYWRVCWTVLTPFMLIAIFVYTVVNLTPLTYGGTAYPDSAHAAGWTLLAFGVLQVPFWCVYTVVSKRRLGMPEMILASMKPSDDWGPLSESNLQAWRRFKETRRIKREKRRASKLRQFLCVLNQSNGVTNHGFVSDETNPRISVCSSVSGIKDVNGTEGKSKTNHERAQWGNDREFLLSCIAMSIGLGNVWRFPFTAYENGGGAFLIPYIIILTVVGRPFYLLEMILGQFSSKSTIKIWDMVPAFRGIGYAQVMVLVGLASYYCSLMALTMFYLIASFQAELPWSKCRPEWGPNCLDSTRNKSIPIPKNVSLKSSAELYFYKEVLREKANIDDGIGAPDWRLTLCLAASWLVILLVVIKGVKSSGKAAYFLAIFPYVVMIGLLARAVTLDGASNGILYFITPVWDKLWRPQVWYYAVSQCFFSLTVCFGAIVMFSSHNRFEHNVYRDAQIVTTLDIFTSLLAGCTIFGILGNLAHELGSDDISTVVRGGTGLAFISYPDAIAKFTWLPQFFAVIFFVMMFVLGIGSEAALTSSIITIVHDQFPHWRLWHIASGVVAVEFLIGLIYVTPGGQFMVTFVDYYATSFIAFVPAFFELIAVFYAYGYNNFLNDVEFMLKRRLSIFWRFCWRFLTPTIIAVIFIYSMVSIKLLTYNDVTYPSYLYVIGWILFSIAFVQIPFWWLVAIVKKRNYSFPEIFRRALDPSKKWGPKNHETRKQWKLFRKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0K1</accession>
    <name>A0A232F0K1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001423">
        <property type="protein sequence ID" value="OXU24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0K1"/>
    <dbReference type="STRING" id="543379.A0A232F0K1"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="855"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1076" mass="124357" checksum="7767475AACBE2569" modified="2017-10-25" version="1" fragment="single">MSFADYGFEVFPIDSQNRANVIHSCGDYLPSSVPLSGKNNSSPYVENSCYQLIIDHLIYLGTCTENELALVQSELEKYKKLQLTEEQMKLLRRLDADCKKLEEIRRLASDSEIDNSPYSSKVCRNLCDDDHDNRRRPLNESKGGEQNVQSKNAILMSEESFRATIIQKDSEIISLKNEKAVKETELRELEEEKRKLEVVMEKLRRDIELLESSSRISQSNAEEITRQKNEELEALRRKSEITEEKLSLEYEARISAEHKLQTVIGEIQALRKNLADESKTAKRRVQSLEESNASQTAAIKQLQRERDDLEKQNIEQENEIEKLLSITKRLNEKHERSKAELSASERRVGQCREQLEKVEHEVSRLIAELSDCLGRVDPSIAEPLEEDLYARASQLTRGLSKFVREHGRCHADRQDLLQQIDRLSTARPPNKASDRISAENYRAIKSDLQGIVDELLSRLDEARRLEKSQRAYLQLAGEASLALQKLEQKIDDHHVYKRCESFLLLELENLQDALDGAEKTINGLECDKIARTELERDYSEVEAVLSKKILQRVQNSTRIVVRITTALRDDSKLKTTYNRNLENQLQQALLALNEIGIEKCQLQSDFTEADEKRNELALQVDKLRAALAEKSDELESTRKQASLAEKKFHESRSENAALIAKSDEMIESLQRELQNREAKLRDYGKFNDFLNGKLEESNRMIEQLQNSIVRENMRKLDLDSFTALHERILELVAEKDELTDKIAMLQSQLASYERNNDKLQTDLTKLLEDNDSLEKDIRKFKGENERLASHMIKENKAENANIRAKCDEVVQKVGKISRDSRLVCPQRLGNSSSSCNDKKELKAHKDKLCYQEKELMMKEREIVEMRKSIECLNAEIAELRKKENNCSLLKRIEILTREKTELKDELKQTLAKYEDKLAEMHKQYKQSEIELHKKHNDSIRRLEAKYTEMMRVDGEAVFDSKNWLKSLSPSELQEVHDEICKTPLCSASTYEKELYEDQTKRSLKNYGIKKPLQTRKGTTNIDEYVSLVTITVSPYMHRLARPEKYVNEHVGEGKLEQSVDNRPGEGRLVPAAQNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0K4</accession>
    <name>A0A232F0K4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001343">
        <property type="protein sequence ID" value="OXU24296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F0K4"/>
    <dbReference type="OrthoDB" id="7694372at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="875"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="1744"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="659"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="727"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="894"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1802"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="913"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="961"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="976"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1080"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1366"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1410"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1494"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1556"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1574"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1596"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1636"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1676"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1710"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1851" mass="205563" checksum="5A817020C8A25B12" modified="2017-10-25" version="1">MELEGDSLLPIADEQETVSMELNTSAGMDLLSQCQTHEVEGAVIIYDTESQEMAEEDKSSEDPDNFITLHASTDVKSEVQEEAASAENLDEVDNETDDDETIATFVTSTGQQLALYAVEDSDEIFAVALYDESGEPPTNFHFLMKADVERLIGEGAVKTVKKPQAQPNRESKPAEKKEEIKFERLSDLQAKAEKEEAAAVQLKKVQEMQNEKKREEVAAAAAAAAAATAASVQLKTVHLVQTEKKEEAVAAPVQLKKVHETKVDIKEEVASPAQLKNLHEMKSEIKEETTSAPAPVPAQLKKVHEMKTEKKDVVGASQFKKVHDLKTENKEEAAQLKKIHEVKTEIVEVPGPQPKAQTPKPQCRIVQKVEQKKAVGTPNRNLINRNINSPNVSTITKTTKTYGNIKSPNASTITKTYSNMKTPAGTPTITRVIKTYANMNTPSGSTIAKTTKTYGNAPGVSTVYKTTKPIGNINSPNASTITKTTKTIGNINSPSASTITKTTKIIGSTYQPRMTQPKKETKVAYVVSNDSQYVIDNVLEDLDSDTEIIEESTVQYILCDGDPSDSEMTFDELQASLQSFKANKPSVNQTKTSTPQKTEKKKETIIRYSTFLKSSSKVAPILSQKREPVTTVYRTYSKSPKKARMTNNLLHPMKKIKQEVEDSSYGDTSAFDDGHLSSDDLSRNTSKQNASMSDTPGMVKVKRSRKQQLTMVNRTDSEIIIQSAYSEGEEEPVVMKKRGRRRKKLSPDPDYNPRKVLKKAKKANRSVEVIEIDVDESERASGQDSTLEGNKGKCSSDKENETISVNDSEAEAEVEEEPSAPKKVKQPMMQCSHCNRNFRKRKALEKHVQVCPKSPAYIQKLEERKKLAAQSGKRFKCKSCEETFDIAVSLARHVRVVHSLRKKKTKTERSESSESEEEEEDVPGESMEESSPKPESARKRRGRPPAKKSLANESPSSNIELKLDSSTESLHQEPKKRGRPPGRKSVVKAPRKRSISKERSLSPDSEDAAVSSESLPKKRGKPTRRNLSKDDEQEAPEGEGKIDSSNETEKTLESTPLKKETKPMVVLVNFSKVGKSMNSEADETYESSDEMPLEARKKRSNKRSVSKDDKSVSSEGEKKNDSSDETPLEARKKTRSNKTSVSKDDTEAEEKNYSSDEAPLEARKKARTSKASVAKEDSSVTAEADEKNESLDEAPLEARKKAIMSKPSTSKDDRSVSPEVKDERSKAVEEKSKEARSATPDPEKKEEKTAELSEELKEVPAKKTVEETVQEIKENPITEAPKKRKLSKDESKNVDDSAPFKPEDKVETSVEVSVEPSRKKTRSAKESISTDEESEIQIAKEKSEDSEAPSGTRKKGRPSKAKLTVEEEMEALMAEDEPESSTENPTESRNRGKPSGARTSVEEELEVPVEEEKEKPAKVSEHSAEIRRKSRSSKDVTSAKEDETEISDSKESTSESSEHPRKQVRSSKDVPATKDDEPEIPDSKESTSECPEIPQKRDRSSKERLSKDDESESPDREEKTETTSETPRRRGRPSKDKSSKSESVDDSATEVETPVTEEKTESACETPRRRGRPSKNQSSKSESVDNSARGVETSVTEEKTESASETPRRRGRPTKDQASKSESVDDSATEADAPVTEEKTENASETPRRRGRPTKDQASKSESVDDSATEADTPVTEEKTENASETPRRRGRPTKDQASKSESVDDLATEVDKKVESPATDDKDKGKTKKKVQSPSRTWKVKKLNCEDCGKWFSSATLLKTHRLQHRTKKSARLDADRCPLCRKAIPGDLFAKHMATVHKKKSPTIVGATRRPDVRRVAKPARKPRNSDPFTAFRVSLNDKLRDSSKSEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0U2</accession>
    <name>A0A232F0U2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001376">
        <property type="protein sequence ID" value="OXU24189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0U2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6406" checksum="AEEC754D9C4E8D00" modified="2017-10-25" version="1">MLSTTTSCSRPTRMTFLRRGRIHPSPSFPGARFVAILLGDDGTGARNGRGDSADDFHAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1H5</accession>
    <name>A0A232F1H5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001351">
        <property type="protein sequence ID" value="OXU24277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1H5"/>
    <dbReference type="STRING" id="543379.A0A232F1H5"/>
    <dbReference type="OrthoDB" id="5920040at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13410" checksum="1E96110302A1633B" modified="2017-10-25" version="1">MPSAVVKIIGKSGSDITCRVLLDTRCIANFITENLCNKLKLTKSPCSLTITAMNNLNTTANYLTDVTFRSIHSEFKKSLTCFVVKEITNLIPKEPVPRNRLRIPKHLKLADPHFENQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F216</accession>
    <name>A0A232F216_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001266">
        <property type="protein sequence ID" value="OXU24560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F216"/>
    <dbReference type="STRING" id="543379.A0A232F216"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="171"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="399" mass="44732" checksum="8D7BEE0EA88EAAA8" modified="2017-10-25" version="1">MTTSNEQVPVVPNPDYDNDSDPPTSNRRPSNQMQILPDQVQKQLQGKMNGTVSPSQMKAFPQNIIQEETQDAQTANKEATPTKIVTILSNDPNIQIRVLPDENQPMDESSTKDGPAAETEPQGQSETDVNGNEDPSVNGTSMQPLMVSSGPAAVDKLTEDFGQLLEAEIDTDVTIQVGRHTFPAHRLILKARCPELLRTARTVVPLMPAPVPSASDASSTSSCCSGPSKQKKRSAKLQQQKQQEEPKKPVERQLLSYVIELPSPPFTEDLVRGLLRYIYTSRIEVLAGIVEELLVVAGDHRLFELKARLECHLWENLNDDNCLRLLMFADKERNQWDCRKLKRRALKYIKDRIEQIIPREEFKNLKNGHCKLLEEILRAVVFGDDWIEGATQNSTAIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2C2</accession>
    <name>A0A232F2C2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_006902</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001168">
        <property type="protein sequence ID" value="OXU24904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2C2"/>
    <dbReference type="OrthoDB" id="8831087at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144670" description="EGF-like domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1676"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="14">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="14">
        <location>
            <begin position="409"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="14">
        <location>
            <begin position="453"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1278"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="14">
        <location>
            <begin position="1365"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="14">
        <location>
            <begin position="1503"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1720"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1720"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="914"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="977"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="996"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1023"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1056"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1121"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1147"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1211"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU24904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1792" mass="200214" checksum="0F88E11805925C81" modified="2017-10-25" version="1" fragment="single">IMQRQLLAFFLLGLFYAKALQNCEPPHYFKCKTVAVCIAQYFVCDGENDCGDNSDESDCHPQRTKSTFVKPCEPNEYQCHDKVHCIPIEQYCDDEPDCMDGSDEFENCHLKKTCAGFKCKNGQCLHSKNWTCDGVNDCEDSSDEENCENSPIAPENCNNTIGRYLCGNKRCISLSHTCDGKDDCGDGSDENKANCDKALTNCKNSTTNSCNQNCAATPAGSKCWCHPGYVLSGTVCEDIDECKEYGRCSQGCRNTIGSFFCQCAYGYTLQDDGVSCKADNGEALMIFAAKSSIRGYYLDSAIYFPIADDLSHVVGVSLDSTYVYWSDIRLGDEAIFRSLEDGTHREVIVTAGLGCPEDIAVDWITGNIYFTDSMYKQVGVCNHDGSFCTVIIKEATEKPRGIALLPSHGKLYWSDWGDNPHISVAYMDGSNRTFFVKDNIGWPNGLTIDYPSSRLYWVDARLKVIESISLDGTDRRTVLRHVATHPYSIAIFENKLYWSDWSTNSIHSCNKFNGKNYTTLFQKNETVYGIHIYHSSLKVKYGNPCVTKPCSQLCLLAANRTYSCACTLDKELNSDKRTCRDSAKRKHIAVAAGNTIIDYYHELLGRPRMSASLTPNHITAMTYDSIADSIIAADDINKSIFRFNPRTNAINHIIPIVNEIVESMAFDYFGNNLYKSNTIHKKIEVHSLTTGEKTEFSYTENPYDIALVPEEGVMFVAFQTNNEFHVDKAQMNGLGSRTHLIEGLYGPKISLAYDRDTKRIYWCDEGTGRIESFDTQGQHRTLFRSGVNGLVSLAVLDNEVFWTERERNRLNWVDKKQVVPGYKGVNLEVTSQTDAILLSVIDGPYSGDTHACRKNNGDCSHICLVTDASKRLCACPADFVINSDQKTCRPKTACSDDEIKCSVNNACIKKIQKCNYVMDCPDGEDEKDCDSIVVNSKCQPDEFACRSGECINKSNRCDSVFNCQDRSDEEKCENHTCSPDEFRCRDGACITKYFVCNGINDCDDFSDEEDCGGHACDDYSFKCNSGPCIPRNWECDGQVDCNDGSDEHDSCRPTDCAKGMFKCSNGRCVDVLLYCNGSDDCDDNSDEADCPENKRVEALVCNKDQFKCKNSTLCIHDTLRCDDHPDCPHHDDEHGCGRCLDETQFSCRNGKCVPVEWMCDNVDDCGDNSDEQNAHCEALKHGPNSTASTALGTTPGLAERAHKCSEGKFACATGYCLPLDMFCDGKEHCLDGSDEGGQCNTTCETNTCENVCHKTPVGPVCSCRVGYELADDEKSCRDVDECKNNVCQQLCENRPGSFVCSCYEGYALRINRVSCKATGPAVKLIAASKDDIRIMSPSTMINSLTIIHRDPEVEITGLDVDSKENTIYWSNEIEGIINKMNIDTKKRVTASNGVGRPETLAVDWITDNVYYFDDKRRPLIKACNVDANKCAVITHIEGMYQRVTTIAIEPLKEMLFWGQVMWKIYEKPSSEIVRSDLMGANQKVIVRDNLGIISGLTIDYHRSILYWSDKYLNSIESVDFDGNNRKAIVADLTTKPIGLFFYEDSLYWKIEGIGVLKRRHLYGNMDSEWISMGSKNSRLFVVSQITRQPDAPNKCKDRGCEHMCVMHKNESTCICGNGFPATLRGNVGCPADAEDEGELELEDNNHGVKVKLDETGPIVTRAQTQSTERKTGSGTITGLSVTLVTFALMFSVYYYLKKKKSGLFKRRDLSIHFQNPSFARRNNNNNNNAATTDTSSILMPGEHEYSNPITEMSNTKLNRIDSGSKKRLELSPELSDGEIEEANTTYNTRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2G6</accession>
    <name>A0A232F2G6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Huntingtin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in microtubule-mediated transport or vesicle function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the huntingtin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001167">
        <property type="protein sequence ID" value="OXU24911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2G6"/>
    <dbReference type="OrthoDB" id="10065698at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048412">
        <property type="entry name" value="Htt_bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048413">
        <property type="entry name" value="Htt_C-HEAT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048411">
        <property type="entry name" value="Htt_N_HEAT_rpt-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000091">
        <property type="entry name" value="Huntingtin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028426">
        <property type="entry name" value="Huntingtin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024613">
        <property type="entry name" value="Huntingtin_N_HEAT_rpt-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170:SF10">
        <property type="entry name" value="HUNTINGTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10170">
        <property type="entry name" value="HUNTINGTON DISEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20925">
        <property type="entry name" value="Htt_bridge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20927">
        <property type="entry name" value="Htt_C-HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12372">
        <property type="entry name" value="Htt_N-HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20926">
        <property type="entry name" value="Htt_N-HEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00375">
        <property type="entry name" value="HUNTINGTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="7">
        <location>
            <begin position="635"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="943"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2886" mass="323461" checksum="50EBF96EF9E1BA90" modified="2017-10-25" version="1">MAARGIIAKAVENLRSLQIQESLATDHEDKKKEKIANCVALTNGISIASVKDAPQVLNLSIETLLCLCDDSDSDVRTVADECLNKIIRAIADSYVLKVQFELYREIKRNGAARCLRAALWRFGLLSHMIRPVKAKVFASQLTPCILEIAKRREDIVIETLSQSLPLILKTLGHYIPDKDIQALLEAFFKNVTSSEAILRRASANMILVTCLNCRKPIQFMNYVIEVLTDMLSRVAEGNMEEEEGKEDRVNMILGVFACLRLILPSIDANSDLTQDFNEDHILDHHICIYELSLFYAKFYTNHNVINAALETLAQLLQNPPKNVVSALLSKDGITQRINKLKERGKQWPSRISLSTTVYSEDNLESSSNLFESDIMDIPEIAPKVEKWMTDIADVMPTVEKAPSKLDISDSSQIIDTKDIDDYSGLIIGSIENESMELESNAGSDVGRFEKPIDTSLLHCSDLKEVEEDLDDTTVSIVSTHDVSLHQFMLQRNDLAIGSLLDNDVSLHYYPQIRGNVLLAVGYFLQGIFLQNNGCFSKESSESSVTIENLIQLILKGLEDESATTCRQTLTALGVFLPSLLESEESKYAILVLKVLPSLVKNPYFLVKIKLLEIVSELPYTTIEHVCGELQFQENIINVLLKLLSDQDQRVRKAASIAITKIVPCLYSQSPHEDAVTRKASLYAERYLTCVVGSPTDPTASFYIEHKLLINSLVSPYDALFRSSSQDRGSRERTDEALSRILGHLVDRLLIPSTKYTAYGCCEALSLLSETFLTTIYPKAWDCFVPAGRVAVKKAVKKTAVRPDSADCCFGFTNEMLSPISNNLFCQSIILLSSSPLSLDLCMHRHLLLLAGNIASGIASTNSRQMHASNSSSSSTSSKSETETTGGDFKYWTFFKDKQSSRNMEQLLVHVMRVLNIFQHVVEDLPSPIQPVSKSSLASLSPAQSLSPKRKLLPDHQSSKSKSSSSSSGSSEHHHRLGFRFGGKEQMGSLSNNAHYLRLYELLRAAHANYQVTLDQDASALYVGLLNACLQVLSQILEIASINEAGRIAEELLSYLQSTVLLSSTYTVQCVRQLLKCLFGTNLVARWQDIYEAQAKQEKRENSGLQDEEFGKAEFEVERGFYEQCFQKPAKLMVERIKGIGSNCRGGNEPDATHRTLVTSLHRKEDRKVSSILKMLSRNSDQNSVGSFIRLFEPLVIKSLIQYTISNSVPLQCQVLMLLSQLVQLHINYCLMDSDKIFIGFVMKQFEFIEEGHIGLTEQLLPRIFDFLVRLSYEKYHSKLIIGVPKIIQLCDGLMASGQPPLTHCIPALVPVVEEMFLARNTPANVSEEKELETTREVLISMMLRLVEYPQIIELLAKCLTESRLSNDGNGEEKWRRWSRQTMDTLLPMLATRKVRVESKRAYFALVKLFSAVSPTVFRPVDPLLRVLFTMPPPVGKNLISYNVPSTSKNILEFKRWIGMVNLIILSLISYAKEEVMLARLSDITSSVTDLPEILLIPDSSRPVIGDPLNVSGLLESFSMPPERILARFIFRVIGSMSSVFVEMFQGAKLKPLNDTNESDEDEYVIHQFTLLLQLCIHMFETGSHCKVANASMQLVKGDNIPKDERLSLNDLNEVMMEIGSSCPILTCQWIYLLTLLGFDDMRFWSRAIGYPSDNVEAEKPLGSINAKILRRASTILFCDYVCENVSSDSEPLSWLLLHHIETMIGLADESPVRELVAVAVHRDPVASGLFLRAVSDNCCRNGQLIGGPSFIKKLLQCLEGAHQSQSGQLLTVLVPRLLRSKYLALSRMAAKIASRRVEVLLALGKEEAMMQLAREDFKAIMNVLKKENMTKKHGALIGLLNKLATSHYELEALELDHSKPFNPLEVKSIKLDRAWYLSQVRSRCCSPCVSYGCYESAWLLNHLNLDECLQIFSLEDFNVKLLQDCIIVGARLTVQASQQLELDGGVKSIDNSESVLYKAAKISLIGRLRSILQELPASHEIFLPVQNPNDKPKQSNYTSNLSSLLLDKAYRTSLFLLIPVVTSYISCLPKLSLSLDAAHEESFARFALLCLESAHFLLLQQMATPRELELSLKCASIILQDPSASSAFDSSPEHHSWVCSAAAALTEIVGHFCKSSDDNELPGIEQGCSGLQEAIEAGKETKSYAIACLRMSMLVAWLEKRQKSGEEDRRQEIPSFFAKPIKSLIISVARQPLVNSFVLTPPLLWKNGCAIVGTGPTKCHFTLFLSEPNYIPELDVLEEFIFRISLLGWNSRQQFEEIWMVLLGVLNVSQLQNEMESETSTSLSHTASLAVQAITNLLVQTLLLPCPGNPNNGMPIKHTRDPQLSLHKKSTKRLFFVQDLLLWKYENSNIVSTATTVPVLEHLFNRGNLEPRTIDPHNYSYGQLSISYLWSLCSLHEDKLSSSTLSLKKRRDEALAAASLDVNSCIRFLLELYASWMSAGTKLPPRLLYEVVKSLLFVSEMFVERSQFQWMLESCLELWKVHLAEDEILRKHLIVAVCKASAVLTPLDPETLDKVKRSVDVGLKGSLSMRIATLHGILYILQSAVLANCEETMSAVHPLAIEYIQRYIDPRDSNRVTSQSEEHQCTLWALVFFLLEHAEDSPPDVEAPAVLELILSLVSSQGISTSLHRMLLQGLERLVATKSVIGKVSEQVVKISIERLRQTNPALSLPALQLFLTCMYTDTADRFNQPELEEPLPDIEPEILVRSIERSAVIFDKIKKGYPMEVEILCAVLSEVLIDFFPPLEILTKVIGEFLSPQQPHPRLMSAIVFKICERACNSTQLGLLQTWVVFSIQNFIQSLPLIMSTWCLSCFFISTSTNPWLRALFPHVQSRIGKYEYEDKKILCLAASDFYSQLTNESQRETFIKTFEDAAKTPGTPFGDILASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2L7</accession>
    <name>A0A232F2L7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-related protein Rab-11A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001153">
        <property type="protein sequence ID" value="OXU24971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2L7"/>
    <dbReference type="SMR" id="A0A232F2L7"/>
    <dbReference type="STRING" id="543379.A0A232F2L7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU24971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24385" checksum="70054811558DA2FC" modified="2017-10-25" version="1">MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLRELRDHADQNIVIMLVGNKSDLRHLRAVPTDEAKTFAEKNGLSFIETSALDSTNVETAFQNILTEIYRIVSQKQIRDPPEGDTIRPQNVEPIDVKPTMSSEGMRKQCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2R1</accession>
    <name>A0A232F2R1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Uridine kinase</fullName>
            <ecNumber evidence="17">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_010897</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">May contribute to UTP accumulation needed for blast transformation and proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RNF19B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="17"/>
    <dbReference type="EMBL" id="NNAY01001153">
        <property type="protein sequence ID" value="OXU24975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2R1"/>
    <dbReference type="SMR" id="A0A232F2R1"/>
    <dbReference type="STRING" id="543379.A0A232F2R1"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000200">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="19">
        <location>
            <begin position="115"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="20">
        <location>
            <begin position="343"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU24975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="555" mass="62610" checksum="1328D94C06AA50EA" modified="2017-10-25" version="1">MAAKVQHYDPPSSASSESDDCDQCLEDREIFFSDELSEEYRRDMGTPTPAPPSPRPPSTGSQKSPHSRRQRTTSCSQSNKKTAAESILQSKTRTIYTAGRPPWYNSAGQQVEPFVIGICGGSASGKTTVATKIIESLDVPWVTLLSMDSFYKVLNEKQHDMAARNEYNFDHPDAFDFELLRVTLQRLKEGRKVEVPIYNFVTHSRETRTKMMYGANVIIFEGILTFYNAEVLKMCDMKVFVDTDADVRLARRLRRDISQRGRDLDGVLKQYSTMVKPSFYYYIAPSMVHADIIVPRGGDNEVAIELIVQHVHTQLQLRGFKLREKLAHSYIGQPLPNSLYLLPDTPQVKGLHTFIRNKNTHRDEFIFYSKRLIRLVIEYALSLLPFKEITVETPQGVQYSGKRSASDKICGVSILRAGETMEQAVRDVCKDIRIGKILIQTNLQTGEPELYYLRLPKDIKDYRVILMDATVATGAAAMMAIRVLLDHDVAEDNIMLVSLLMAESGVHSIAYAFPEVKIVTSALDPEINEKFYVLPGIGNFGDRYFGTEPSSTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2V4</accession>
    <name>A0A232F2V4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001203">
        <property type="protein sequence ID" value="OXU24757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2V4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="111" mass="11929" checksum="0F9DF07DB830AF5F" modified="2017-10-25" version="1">MANCNLIKKCFRQKLLGIEGLTLLFASVYLRACVSVSHPLLPSCQASGSPRRRGALGARLRTTFSLPRPGFQTSRTRTEAGADFDEASLTPSSAAVLLSYFCGKRALFACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F301</accession>
    <name>A0A232F301_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001181">
        <property type="protein sequence ID" value="OXU24833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F301"/>
    <dbReference type="STRING" id="543379.A0A232F301"/>
    <dbReference type="OrthoDB" id="6343941at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="328" mass="36921" checksum="C251D3D19EA84FCC" modified="2017-10-25" version="1" fragment="single">FAEQEVEEEEEEEEEEEEKGTLGEIDVTIKIPIAVAENSTVNMTCEYNLRNMPLYSVKWYKSQNEFYRFIPKEMPSKSVFPPLSAKVDVISVMKSSTLQLNKSDEHTVVLKNVEADLAGKYRCEVSTDAPTFITRMESSYMHVVRLPEGNLTVRMEKPRYALGDTVRGNCTAPPGNPAANITWTVNELPVNSSYIRNIPTRNVTDNRTISIAGLEFELVPESFSNGRLRITCRADVFHLYDKKATVVLDEERPRLASVLGTRESSHSHSTFDYLLAKESFITYISPAEEKPSFFHLYVMSLPQTGSSGASDATSWLLGLTIAILARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F302</accession>
    <name>A0A232F302_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 170A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001174">
        <property type="protein sequence ID" value="OXU24868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F302"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19976" checksum="6776CD19AC7A0929" modified="2017-10-25" version="1">MPHAQLEVTAASASAPDEASSSIYDAPLTSFAGVYPCPFHPCSFMLFQLTPPELLIDIDYRQHKHFNCSKEFMQLTDSDFPEMWYQIFLWALFSSIFVHTIAAGICFATLRKHKYGKFFPLLILIMGVLMPLTSGVVSSAAVAFVYGSAGYQMAPQYALLWGIGQTVLAACVGFTRILATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3H4</accession>
    <name>A0A232F3H4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_009545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001103">
        <property type="protein sequence ID" value="OXU25132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3H4"/>
    <dbReference type="STRING" id="543379.A0A232F3H4"/>
    <dbReference type="OrthoDB" id="10037120at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070976">
        <property type="term" value="F:TIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035325">
        <property type="term" value="F:Toll-like receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002755">
        <property type="term" value="P:MyD88-dependent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008063">
        <property type="term" value="P:Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017281">
        <property type="entry name" value="Myelin_different_resp_MyD88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079">
        <property type="entry name" value="MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079:SF3">
        <property type="entry name" value="MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="5">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="6">
        <location>
            <begin position="151"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47287" checksum="35781792AC35931D" modified="2017-10-25" version="1">MPDLSLVPLTALSPEVQHLISTFLNPPKVIPAGCGTSGLPRDWRGLAQVCSIGGELMPAIASHADPTKRILDIVQTKSQNFTLKSLQDALKSLERWDILEDSEPLLERDALLYMERLKKSQETAEGNDYSADAEILTFDDQFRIERGEGKQHYDAFLLYADVDEEFALEMIENLEKKNNLKVLCLKERDLVPGLSFEHEAIMRLISERCNRLITIISPDFFKSPANKFFLNYAQASGIDKRQERKIIPCVYKNCELPPQLTYYSKIYYKNVSADFFWDKLTRSMKAIQSVQNAQMFTQNSSNSKAKSSNSTKNTPVQEPKKKVEQNPPVETSKAVNGLKNRGLLPWKRRENAELSEKPNKKDEKLVTQDPIPKLPSLDGLDSLSCVTSSANTTTKKSKKNKMFLGSYVKKVQSLLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3M3</accession>
    <name>A0A232F3M3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_014601</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001126">
        <property type="protein sequence ID" value="OXU25043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3M3"/>
    <dbReference type="STRING" id="543379.A0A232F3M3"/>
    <dbReference type="OrthoDB" id="5956310at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15331">
        <property type="entry name" value="7tmA_5-HT1A_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF200">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="400" mass="43583" checksum="3767529E78CCD4F3" modified="2017-10-25" version="1">MSVAAANVSQAANASFVGTASFSDITVILTALVLGVLILTTVIGNVFVIAAIVMERNLQSVANYLIVSLAVADLMVACLVMPLGAVAEINSGWTLGPELCDMWTSSDVLCCTASILHLVAIAVDRYWAVTDLNYIQARNPRRIGFLVVAVWVSSLGVSLAPQLGWKDPGYLDRIAEGKCLVSQDPAYQIFATCATFYLPLLVILILYWRIFQAARRRIRKRPGTTIQPPKERRGILRLVKRQESTAFTIARSTPDHSSVSPEKSSSYNGANNPPPTTASATSTTTLTTATTSTTTTTTTTTTASTRKTRETIEAKRERKAAKTLAIITGAFVACWLPFFFVALLQAVCEPCRPPDLLASVFLWLGYLNSTLNPVIYTVFSPEFRQAFKRILGMQPRPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3V2</accession>
    <name>A0A232F3V2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001046">
        <property type="protein sequence ID" value="OXU25355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3V2"/>
    <dbReference type="OrthoDB" id="447510at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019799">
        <property type="term" value="F:tubulin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03130">
        <property type="entry name" value="mec17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038746">
        <property type="entry name" value="Atat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007965">
        <property type="entry name" value="GNAT_ATAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12327:SF0">
        <property type="entry name" value="ALPHA-TUBULIN N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05301">
        <property type="entry name" value="Acetyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51730">
        <property type="entry name" value="GNAT_ATAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="405" mass="45921" checksum="3489C2DCD623E73E" modified="2017-10-25" version="1" fragment="single">FSNTSLRSLHFDKQTFINMDFRFDINKLLPKRINKITHTLIPEGFRGDRREYNDCQRLLTRILDDMGEASAKAQGLNRTITSALKLRDTDHIIYLMVDNEGNNGLGSVVGLLKTGSKLLFMFDENGRHYQIKPRCILDFYIHESRQRMGLGMELYQHMLSEENLKPIKLAIDRPSDKFLSFLMKHYGLTTIIPQNNKFVVFKGFFDDEIEESQSSNNRNNSASPTRQSVDGNNQTNLTDIQSPRNNSNGTPRSAYGRYAASRPPCSMATIIHHAVTDQPANTKSSLRMFPDRPDSVTFSNYEKQEKETAEIEDGNDSITIAETMVEDMHIHEDNDTETLFSQPDGVTDDVKDELEETPDALAETNDNDKIDSAISVAGSEEVPVDENALTSAGHLDLKFYHSPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F413</accession>
    <name>A0A232F413_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_000311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001009">
        <property type="protein sequence ID" value="OXU25501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F413"/>
    <dbReference type="STRING" id="543379.A0A232F413"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="37"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="482" mass="53382" checksum="F4A46A21A28BB1AB" modified="2017-10-25" version="1">MDVDKISVFTAVGFALAVGAFVLWGPSPRPRRKGQVVGIKNLGYTCFLNSLLQSLAACPAFIEWLRRRQEDVKGESFTSSLMLVTDKINGFTDDMFGSVRPVEVITSLGPLWNFAPGHQDAHELFHVFLSALQAELQTACRKGCLSDALPKAPLVITDIKGSGDPVNLRSVSCNDIASANERCEVPRETNKNLSNHVVTYAQSITNVSASMTSIKPGIILARSSEIISKIIGESGDDGDSLRPWSSMCAIPSQNTTPSFSNKVHPFSGLLTSQLICTECEWKSPVHFDKLESVSLPLPPVTDGFMWNRLTLVDLLSRLVSKEVINDVQCDGCNNRCAAYKTLTFGKLPRCLCLHIPRTTWSSSGKPIKRDDPVIFNEALILDPFTYTDTKRKNTQSQGSLHSMALLNGQSLQRGKHKYYLYAVIEHRGPVDAGHFVCYRRGNRPGQWLYTSDTIVQKTTLEDVLSASPYLLFYERAVTRDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4C6</accession>
    <name>A0A232F4C6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001059">
        <property type="protein sequence ID" value="OXU25303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4C6"/>
    <dbReference type="SMR" id="A0A232F4C6"/>
    <dbReference type="STRING" id="543379.A0A232F4C6"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="98"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="277"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="340" mass="36609" checksum="266C18DFA322A9A3" modified="2017-10-25" version="1">MTTEVASTVVEEEDYGDCQGQAKLIKTLEGNGITAGDIKKLEEAGYFTVESVAYTPKKVLMAIKGISEGKADKILQEASKLVAMGFKTAAEVHMIRANIVYITTGSAELDRLLGGGIETGSITEIFGEFRTGKSQLCHTLAVNCQLPVDMGGAEAKCIYIDTEGTFRPERLIAVAERYNINGDSVLDNVATARAYNSDHQTQLLIKASAMMSESRYGLLIVDSATALYRTDFAGRGELAARQMHLARFLRLLLRLADEFGCAVVITNQVVASVDGAASMFGGDQKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPESEATFAINADGIGDVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4H5</accession>
    <name>A0A232F4H5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001045">
        <property type="protein sequence ID" value="OXU25363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4H5"/>
    <dbReference type="STRING" id="543379.A0A232F4H5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="9618" checksum="AB0117CBBE1A962D" modified="2017-10-25" version="1">MSSTLRAQSTGGELTNLSSAGSDRTLATSTGGSSHTHSHRKHHNHHRSRSAPRAPEKPPRKRHMNPGQSLASIPSQIKLSMLNSGLISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4U2</accession>
    <name>A0A232F4U2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="11">HIBADH</shortName>
            <ecNumber evidence="11">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_007964</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01000942">
        <property type="protein sequence ID" value="OXU25801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4U2"/>
    <dbReference type="STRING" id="543379.A0A232F4U2"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000119">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="13">
        <location>
            <begin position="188"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="322" mass="33780" checksum="35A930D63C24133F" modified="2017-10-25" version="1">MGVLTKLTRPLAIYTVRRVGQRDFSNVGFVGLGNMGGFMAKNLLKKGYKLTVFDINKTAIDNVVSAGAKSAQSVAEVSQNSEVIVTMLPMNQHVLDTYTGKDGIISSAKKGTFLVDSSTIDPSVSQTVFKAAQKQGLRFVDGPVSGGVIGAKNGTLTFMVGGSKEDYEASKTFLEGMGSRAVHCGDTGMGQVAKICNNMLLAISMIGVSEALSLGEKLGLDPKILTDIVNTSTGRCWSSEVNNPVPGISPTVPSSNDYAGGFGTSLIAKDLGLAQAAATRAKSPIALGSLSHQIYRTMEAHGLGGKDFSVVYPFIRGENVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5X8</accession>
    <name>A0A232F5X8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pacifastin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the protease inhibitor I19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000923">
        <property type="protein sequence ID" value="OXU25883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5X8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008037">
        <property type="entry name" value="Pacifastin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036201">
        <property type="entry name" value="Pacifastin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05375">
        <property type="entry name" value="Pacifastin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57283">
        <property type="entry name" value="PMP inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51446">
        <property type="entry name" value="PACIFASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059425" description="Pacifastin domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Pacifastin" evidence="9">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="10393" checksum="F8E9FF6965425007" modified="2017-10-25" version="1">MSKVLKIGLLLLLVAVAASAYAVAEENAAPEDSAVEVKAEKGANNQIKNKQFPQIDDYDVTNKCPANQSFKWKCNYCTCGPKGKDASCTRMACPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F612</accession>
    <name>A0A232F612_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000833">
        <property type="protein sequence ID" value="OXU26274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F612"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="147" mass="16315" checksum="62DEA13C09EF5471" modified="2017-10-25" version="1">MGQSDPTPVTRLIRRSIHLLLLCEYSKVKIISRIKALIDPQKKADVQSTRKRLLGIQNYARQSARDGAPLNASRILIHSRFGGSPIPPSLSLSLASVCEIKYRSFLHFSTIRVLPISARYLSACQEAIFSSRAMASGSCFRGDQRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F651</accession>
    <name>A0A232F651_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000919">
        <property type="protein sequence ID" value="OXU25928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F651"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12580" checksum="FC4738B6346D39DC" modified="2017-10-25" version="1">MLFALSMNYSHLVSRIIELPVDPLAMNCSTSPSRARVFQCPTCPKRFSAKSSVIQHIKYDCNRLPRFVCPYCDKRSKYPFSLYKHIRDVHPDCKVYCKDLSGEKEDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6D0</accession>
    <name>A0A232F6D0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyl-D-glucosamine kinase</fullName>
            <ecNumber evidence="2">2.7.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GlcNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_004812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type N-acetylglucosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.59" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000854">
        <property type="protein sequence ID" value="OXU26195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6D0"/>
    <dbReference type="STRING" id="543379.A0A232F6D0"/>
    <dbReference type="OrthoDB" id="311172at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd24078">
        <property type="entry name" value="ASKHA_NBD_NAGK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039758">
        <property type="entry name" value="NAGK-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862">
        <property type="entry name" value="BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12862:SF0">
        <property type="entry name" value="N-ACETYL-D-GLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase BadF/BadG/BcrA/BcrD type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU26195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="407" mass="44909" checksum="3879DDF4F05DD9D3" modified="2017-10-25" version="1">MERTNGHQTTVSTECLDKDPEHIRIGGLEGGGTHSTLYVVDGRGKKLTEVRGPHTNHWVLGLEETVARINDMIVKSKLELGIPDTVPYDIVVRPFQGLNLSGCEEEKSNRLLAETLHRRYPTASRDYTVGSDTIGSVRTGVSNGGIVLISGTGSNALLINPDGKTYGCGGWGHMMGDEGSAYWLAHRACKYVFDDLDGLSRSPQPISYVWPAMKQYFDITDQQSMLPHIYANFNKCKFAMFTKELALGCERGDPLCLELFREAGVTLAKHVDAVYNKAHNDLKLEKGGVKVICVGSVWKSWEFLKSGFIDEIHRSGVVDELTLLRLTTSAALGACYIAADKLNCKSMNKTFQTNTEKFYHYKRDNLPPATSTGYVYKLMATCDNGVSTTPTATAGYKSNVEQSIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6P6</accession>
    <name>A0A232F6P6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_016782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000875">
        <property type="protein sequence ID" value="OXU26108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6P6"/>
    <dbReference type="STRING" id="543379.A0A232F6P6"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027012">
        <property type="entry name" value="Enkurin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052102">
        <property type="entry name" value="Enkurin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490:SF0">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21490">
        <property type="entry name" value="ENKURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13864">
        <property type="entry name" value="Enkurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51665">
        <property type="entry name" value="ENKURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enkurin" evidence="8">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="276" mass="32977" checksum="AB6739848154948D" modified="2017-10-25" version="1">MTYGYGRDYDENVAKLIVKPPEKFIKSPRYISIHRERTREELSRVKSSHKSLGPPRVPLRPPSDYLKRGSRIAPQPPRVEHVHYRPPDYPRQLPDWRSTVPRTADASAKDFRRRNVENAKRLRPKRPEPLFVDTRKGDRQRLMTSGLQPIYVYKKNFGEVPSQIKRSKSAPWSIKEKSEHRQAEYEQYVKEKLAEEKSRCRYITEDERTKLLEEMKNKWSEVMKQFQCLPFLIDTTAKIKRKASLEEKLKQLEKDIQLIENHPYIYVYDDGQYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F744</accession>
    <name>A0A232F744_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000790">
        <property type="protein sequence ID" value="OXU26495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F744"/>
    <dbReference type="STRING" id="543379.A0A232F744"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000070">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="342" mass="38722" checksum="6AD726D164253770" modified="2017-10-25" version="1">MIGGAPSDVEGEELALDEMAGAEGASDRQYSLSDFELIRVIGRGSYAKVLMVELKQTKRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMFHMQRQRRLPEEHARFYAAEISLALNFLHTKGTLLYFGTLLLCDVRIIYRDLKLDNVLLDHEGHVKLTDYGMCKEGVREGDTTATFCGTPNYIAPEILRGEDYGFSVDWWALGVLVYEMLAGRSPFDIAGASENPDQNTEDYLFQVILQKTIRIPRSLSVKATSVLKGFLCKDPAERLGCGRSPNAFLDIMTHPFFKAIDWDMVRTFGRLSNIDFTFEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7M8</accession>
    <name>A0A232F7M8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000827">
        <property type="protein sequence ID" value="OXU26297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F7M8"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000008">
        <property type="entry name" value="host cell factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000015">
        <property type="entry name" value="host cell factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043536">
        <property type="entry name" value="HCF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059124">
        <property type="entry name" value="Kelch_HCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46003:SF1">
        <property type="entry name" value="HOST CELL FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13854">
        <property type="entry name" value="Kelch_HCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1389"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="978"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1340"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1617"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="398"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1175"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1215"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1350"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1624"/>
            <end position="1643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1643" mass="172803" checksum="6D0E67CEA5CDC6A3" modified="2017-10-25" version="1">MAAPMLKWKRINNPTGPQPRPRHGHRAVAIKDLMVVFGGGNEGIVDELHVYNTATNQWFVPSTKGDIPPGCAAYGFVVDGTRILVFGGMVEYGKYSNELYELQASRWEWKRLKPRPPKHEPPPCPRLGHSFTLIGNKVFLFGGLANDSDDPKNNIPRYLNDLYTLELLPNGATAWEVPQTHGHAPPPRESHTGVAYTDRTTGKSCLVIYGGMSGCRLGDLWFLDVDTMTWNKPVVHGPTPLPRSLHTATLIGHRMYVFGGWVPLVVDDVKVATHEKEWKCTSTLACLNLETLTWEQLTVDSLEENVPRARAGHCAVGVHSRLYVWSGRDGYRKAWNNQVRVCCKDLWYLEVSKPPAPSRVQLTKASTQSLEVSWTPTPSAQYYILQIQKFDMPSASNSSFPASTASSAPANTTAASTPALPSITSSAMQPTPSSNASAAAAPVSTPARPAAAATPAPIRVQSSNQKILTLQPSATTAATAAAAASTAAITASSANKQIVTSASAAMIQRTGNVIRIQQPNVVTSVAAGTLVAAAATTSSTPTTTIASSAITTTTTSTQQPAAMSAMNVLASAAMTHKISMNNVPVIPVQGTTTTAPIRMKSVQTGQQIRFAAPGATVLRAASPQQGKQIILQKPGQNISGQPQIVHLVKTQHGGMVAMPKVSLVPGQKIPTTGAKPLNQGTFLRLVNPNAVGGSKILTTMKASNLVTMSKGQSIAGKQTIMITKPGGNGGLVGRSNQIIVVTTGSGLRTVQAVTTSQAGSGQSTTLATNPVNVLPLSATNHVTNQQGVKMIMVSSSAMAGGTAGKPLTITMPGQGGKTVTIATKTGAPGAILHKNQLVAMPQMQKVGAEGVGKPVTLQMQGGGTKTVTLVPTSSSIVSSSGNVAEAIDTSKMLIVSPQKQPSATLATTSDGPATTDAALAALAAEAGLIDPVQESSGGLFMMACDDSKSQESCNGNQDAAAAATASLVEPMQVDGEGNLVIPQVDGPGDLIFSEDESETTTQEEEEPANADVEQSSESAAQEMEQDVDQGMAAITGDTDEPAEEPATIERSQSSESMNVEAILSGNDGTEQQQESLQEPEKDAESTSQEEAVTAAEPTEATPAEAAEAEASEATAEAEDESMPSKAEDDATVEQQKDEDNQKVEKVVDTETDQAESELMAVDPSPAEEEEKESAEPATVASSETPVSEEPPEQASEESNAPEGETQPIQDSDAAAVKEAEKVSETSNDKVEENKDESEPMNVEPEVEQPDAAASEPAVEPAATPTPAADVAPVDTNVNSQEPESEPPIPPIKEEDLGLDEPMEESSAPITTAPVTTGNGNVAVKKQLKIEKPVVKAELKTQAPVAPTESNKIKQEKSEDSTGGDSMALATLATAALGSTEPAVEPKTVPPTNVAHITKEPPKVKEKKALEWYDVGIIKGHNFTVQHYYLPGDEPLDITQALTADLFKGRTKVSLEPGTAYKFRVAAVNSCGQSPWSEVSAFKTCLPGFPGPPSAIKILKSAEGAQLSWEPPSSNSGPILEYSVYLVVRSASAMSENTGEVTSTTPAQPSFIRVYCGPTNACSVPNKSLSAAHVDTTTKPAIIFRISARNDKGYGPATQVRWLQDPTTAVKNNMQVKRPIADVRSQASSPQKKVKAETTNDNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F866</accession>
    <name>A0A232F866_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_007888</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000759">
        <property type="protein sequence ID" value="OXU26649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F866"/>
    <dbReference type="STRING" id="543379.A0A232F866"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="53"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="318"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="526" mass="56901" checksum="D904F8FB11C203D8" modified="2017-10-25" version="1">MSSISRCLRSIEHSPVIQIPKWLPHHMCLSDVTSKVYLLQKRFYSSKVKLNDVVIVSAARTPMGSFLGSLSSMSATKLGAVAIQAAIERAGIAKEQVKEVYMGNVCQAYLGQAPARQATLFAGLPKSTICTTVNKVCASGMKSVMLASQALQCGHQDIVLAGGMESMSNVPFYLKRGETTYGGVKLEDGIVFDGLTDVYNKFHMGNCAENTAKKLGISREQQDEFAINSYKRSAAAYEQNAFKDELVPVNVPQKKGKPDVVFSADEEYKRVNFEKFGKLSTVFQRENGTVTAGNASTLNDGAAALILTTADNAQKLNLKPLARVVGFQDAATEPIDFPIAPALAIPTLLQNAGLNKNDIALWEINEAFSVVVVANQKLLDIDPAKVNVHGGAVSLGHPIGMSGARIIVHLVHALKAGEKGVASICNGGGGASSILIEKLSHVHSSPPKLTLYTKDVCPLCDIVKDELKLKFNGQYQLEIVNITAPGNEHLKKLYQYEIPVLFLEGQYLCKHKLDVELLEKRLASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8H8</accession>
    <name>A0A232F8H8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Voltage-dependent calcium channel type A subunit alpha-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_015744</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000767">
        <property type="protein sequence ID" value="OXU26617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8H8"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000043">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000059">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000011">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000013">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000023">
        <property type="entry name" value="Voltage-dependent R-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14 18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="832"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="899"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1085"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1166"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1196"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1231"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1276"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1375"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1415"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="753"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1584"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1056"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="18">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU26617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1743" mass="199082" checksum="7FA2DB4897E10057" modified="2017-10-25" version="1">MFAMQTFWKRLSTHMLIFRIDKLGVAYKLAAQQAAQRDSGYTSQYRRRQRWTGVSGLGDWVGVGGEVSGQAMAPGRDQGGGTGDGGGKGPSSLFILSEDNCIRKHTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPCHDKTTLAKKLETTEIYFLGIFCVEASLKILALGFVLHRGSYLRNIWNIMDFFVVVTGSMTVFAETNVDVDLRMLRSFRVLRPLKLVSKIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGTLHKTCYSIENAEQIVKDGEQPNPCNTDNQDEAPMGAHVCNANTSKCSDRWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSTFNWIYFIPLIVIGEFAKEREKVENRQTFLKMRRHQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRAAAKRKKLKNLGKSKSTDTEEEDAEDDQEDGFGRASYLKSKVKNQGACAEFWRNEKRFRFWIRHTVKTQWFYWFVIILVFFNTVCVAVEHYVYTEFVFLGLFMCEMVIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSAVKSGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNFETGTPPTNFNTFPIALLTVFQILTGEDWNEVMYQGIQSQGGHKKGMIYSLYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQEEEDKEKQIQELEKEMESLQKPSDGSAPKVEISPPSPTANFKGGKGGKQASEEKKQDDEDDSGPKPMLPYSSMFILSPTNPVRRGAHWVVNLRYFDFFIMVVISLSSIALAAEDPVNDSNPRNTILNYFDYAFTGVFTIEMILKIIDLGVILHPGSYLREFWNFMDAIVVVCAAVSFTFDMMSGGEGGGSASKNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVINILIVYILFQFIFAVIAVQLFNGKFFYCTDDSKYTKEDCQGWFFQFEEGELHPEAKERKWESQSFHYDNVMVAMLTLFAVQTGEGWPQVLQNSMAATYENKGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIQARPLERYMPKERNSMKYKIWRIVMSTPFEYFIMILIVLNTLLLMMKYHKQSDVYKNTLKYMNMCFTGMFTVECIMKIAAFGVRNFFKDPWNTFDFITVIGSIVDALVIEFGENFINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNLANDPTTAIESHNNFQSFFGGLMLLFRCATGEAWPNIMLACIADQPCDPRSKETGDKCGSNLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPVDVDGKVNFTTTLFALIRENLSIKMRNADEMDQADEELRDTIRNIWPLQAKKLLDLLVPRAEAVKKEKLTVGKIYAGLLILESWKATRFGQKESTQRSAFLEALLDAAAVNHAGNNHHPSSRTNSLEPPGAPDHKEHPHLPRGSHGDEEEGPLGIFAAAEQRRQRSIRNKKVNWKVSQQYDKLASNGESSQGGVGPRGAGFHGSAIISNGDERLSPDLEPLLTEPSRPARREYAQYCHHHLYHRLRNRNRYRNHRADLSLYIIFSLITLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9A8</accession>
    <name>A0A232F9A8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_003761</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000606">
        <property type="protein sequence ID" value="OXU27416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9A8"/>
    <dbReference type="STRING" id="543379.A0A232F9A8"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000033">
        <property type="entry name" value="Phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041503">
        <property type="entry name" value="AIMP2_thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18569">
        <property type="entry name" value="Thioredoxin_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="224"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU27416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="722" mass="82128" checksum="D0A9123AFAF0C8D4" modified="2017-10-25" version="1">MATELMEKILDRLSKHDEVDSLDLAQNFGVDHQKIVGAIKSLQAFEDLLKVESKSRKEWILTEEGQHVLENGSHEAAVFNAVPADENGAKQADILSKVPFAKVGLSKALAAQWVQLVKSENDTFIKRKVPSITDQIQKHLKELQTLSDDSKKEYKKRKLIKENIIKIMVLQKGENFSTKIEKPEADLTADLLVNDAWKEKKFKPINLDALGAPLDVGHLHPLLKVRTEFRKIFLEMGFQEMPTNNYVENSFWNFDALFQPQQHPARDAHDTFFISDPAASTSFPEDYLEKVRKVHSEGGYGSQGYGYDWKIEEAQKNLLRTHTTAVSARMLYRLMKKGKFEPVRYFSIDRVFRNETLDATHLAEFHQVEGVIADYDLTLGDLIGTLYEFFSKLGITKLEFKPAYNPYTEPSMEIFCFHEGLGKWIEIGNSGIFRPEMLLPMGLPENVNVIAWGLSLERPTMIKYGLNNIRDLVGPKVDLQMVQDNPLCRLDNIRSSSFTFLSKVTNPDFVGRCEVSAAGSRQAEGETFSDESLLARNQRTANTDPIVEDVVVFCDPSRMPYFMKPLLNLLRQIFAVRASVHRHSSLSSNNASSQELRSFSESLTSAPVDTSLPELRFVLIWRRDEAACISLRYGTGHEIAGQVNVARCLTRLVEQRRPELLRYESLGAAYANQVDSVLKRLEEIEPFDKARLEALCKKEKAHRKSKYFFGDEMSVIDVFLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9G9</accession>
    <name>A0A232F9G9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000691">
        <property type="protein sequence ID" value="OXU26957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9G9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="10160" checksum="7EEF0CA35F938C85" modified="2017-10-25" version="1">MLSSRLPSLDPHSRNFTARSHQQNFFLLFHTLHTITRYTLCTIKILALAQKSSIYEYIDEMINCPMPGKEAAGCYRLGFAKIREYDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9Z8</accession>
    <name>A0A232F9Z8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000660">
        <property type="protein sequence ID" value="OXU27137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9Z8"/>
    <dbReference type="OrthoDB" id="7407406at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="123" mass="14650" checksum="A0571238F1484B69" modified="2017-10-25" version="1">MINILRCCTGRLQVTPVTTIFRRQYMKVSEKMEILLKQADKIPRNFELIYRYPTFRSAGFMFHSVNFMTITTFTIVAYAYYMDKPVNEDERKLDIIQNPVRAVIRPDELRISKFHTTMAKFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAB9</accession>
    <name>A0A232FAB9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000573">
        <property type="protein sequence ID" value="OXU27605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAB9"/>
    <dbReference type="OrthoDB" id="9986793at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="18031" checksum="97DAA9A422A1B6C5" modified="2017-10-25" version="1">MTSVSSHGFHRTGFLMRKMASYMPNEVVDILIILDECIRNYRLLPVLMWSDFQITAILMLDKRALKTLDLNPNFFWEVCFSDEATFISNGSLNRHNCHYWSPENPHWYPSMYGLAFVINGQVIGHYFFERTINGPMYLEFLENDFKIPRECST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAU0</accession>
    <name>A0A232FAU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000582">
        <property type="protein sequence ID" value="OXU27558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAU0"/>
    <dbReference type="STRING" id="543379.A0A232FAU0"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10975">
        <property type="entry name" value="CE4_CDA_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000003">
        <property type="entry name" value="CLUMA_CG003232, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF12">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 5, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="323"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="655" mass="74255" checksum="FA2EFBDB6A95E8FF" modified="2017-10-25" version="1" fragment="single">SVSSESPRIAKTSASTAAPIVSKSYYSEPDQSYPYYTIYDDDVSIYKDDADYNQYTVNTSTPVQPPPPPPQQQNIRAEVSPSSKPYSQKPKKVAVHEADKYNLNQDVTIQDYDIYDNQHISKNKFRITEGQSLRPNVLSHPVVHVTTPNAIIDTFIPLTTTTQSPPPTTARSYSASVPPRGRQQVNRGTAPPRHRPTLKPSTEIVSKAQEFVDIYRYPPVRPAPIYPTPQVDKPAAKCRKDVCLLPDCSCGGADIPGGIAPEDTPQIVLLTFDDAINDLNRQLYVDLFEKGRKNPNGCPISATFYVSHEWTDYRDYLPEEIPQIVLLTFDDSVNDLNKGLYADLFEKGRNNPNGCPISATFYVSHEWTDYSQVQNLYAAGHEIASHTVSHSFGEQFSARKWSREVAGQREILSAYGGVKLEDVRGMRAPFLSVGGNNMFKMLWDTNFTYDSSMPIYENRPPSWPYTLDYKLFHDCMIPPCPTRSYPGLWEVPMVMWQDLNGGRCSMGDACSNPPTADGVYKMLIKNFERHYTTNRAPFGLFYHAAWFTQAHHKEGFISFLDTIVAMDDVWVVTNWQALQWVRNPTPLALLDRFEPFQCNYQDRPKKCNNPKVCNLWHKSGVRYMKTCQACPDIYPWTGKTGIRSSRIDNDIDGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAV1</accession>
    <name>A0A232FAV1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000580">
        <property type="protein sequence ID" value="OXU27568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAV1"/>
    <dbReference type="STRING" id="543379.A0A232FAV1"/>
    <dbReference type="OrthoDB" id="295715at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000072">
        <property type="entry name" value="SOSS complex subunit B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21928" checksum="6C86FF98F7EF4B6C" modified="2017-10-25" version="1">MEYVLIKDIRPGQKNINVVFIVLEVGHPTITKENREVRTLKVADSTACMNVSIWDEPGTLLMPGDIVRLTKGYASVWRNCLTLYSGKTGDIQKIGDFCMVINEQLNMSEPNPTLSNQLVGQGSSTSGSNNSNNNSNNGASVRSSLTTQAPVATTSSATSSKESGKGGNGGEHNGFFLVHNHSDNGLIRQVFWQHKERTSWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAW3</accession>
    <name>A0A232FAW3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Osiris 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000498">
        <property type="protein sequence ID" value="OXU27984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAW3"/>
    <dbReference type="STRING" id="543379.A0A232FAW3"/>
    <dbReference type="OrthoDB" id="6631139at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF2">
        <property type="entry name" value="OSIRIS 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012195519" description="Osiris 20" evidence="3">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30141" checksum="67046250CE664717" modified="2017-10-25" version="1">MRALVVIGIVGLLAAVSSASTSDDFLTRSLNDCIGADSWGSCLKHEVLGYLDDKLGTSTEARSLDSVDEALVARTFKYLKSFEYGVDLPFVDARLKYRPARSLADLDIEFKDNEVATSQARGILKKKLLLPFLLLFKLKMKMLMPIFVAIIGLKAMKALVLSKLAILLVIGFIAVQFFKKGGMAPPMGMSMEPASPPLGSYGAPPVPTTTSGYEPVNTWDGNGPYSRVWTPSSGVEAQNLAYNYYTGSGSSSTYGAPSSSASSSSSSSSSSGASGSGSVSASTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBJ5</accession>
    <name>A0A232FBJ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000535">
        <property type="protein sequence ID" value="OXU27819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBJ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="302" mass="33793" checksum="5B10816FE965C50A" modified="2017-10-25" version="1" fragment="single">MQDCYKESSKIDTVIQQKPINLSSTHSSSTTTPSPAMLTSTSMIIRLVLQPPQRQLYALSKILYARFFGKRSSFFSCYGGFNFDISELRRHLDHRNPPSSPNSVIPHISVQQSHNWRAQQLRLLELHRLLGNDTCRSRSSSRNQCVRQREPENEFVAGRLIKFKVKEEAIDIGSAGSPTNRKLSKPVTPGHKSKPTAAAHHHHQDPYAPDDQGCLMATAEKLEWNSHTHVQIYEDPLVEMLTNGKLLAKVTFLAVNSTSMCKSTRPIIGIDDNLPNNNAINHASATSSHYTTPSSSQHPHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBR8</accession>
    <name>A0A232FBR8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase ZNRF1</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase ZNRF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc/RING finger protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_016341</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000519">
        <property type="protein sequence ID" value="OXU27889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBR8"/>
    <dbReference type="STRING" id="543379.A0A232FBR8"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000235">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU27889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="293" mass="31801" checksum="ECEE944B6F000009" modified="2017-10-25" version="1" fragment="single">GGAGILGSDEEEKGKKIKSRVSSCEEIHNSSSSSSRVGRRRGCSPERFLLLTLQQLWTISRNIVFAFCVPESFEWYLSLEEGMGAKTSTITQNAGGNGQSSTGANETTMQGFSTLRSLPGGVSMLQHQHQQANQSQSSRVSGDSRQRARSLSSVPDISAEQGALASAVGVGVGQVLGLPQLDADDLDEESSRVYAAHSLPSHIWSLNGLKCPVCSKFILPDDIECHLVMCLTKPRLSYNEDVLADEKGECVICLEDLQVGDVIARLPCLCIYHKNCIDKWFQVNRSCPEHPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBV7</accession>
    <name>A0A232FBV7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNK FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000508">
        <property type="protein sequence ID" value="OXU27943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBV7"/>
    <dbReference type="STRING" id="543379.A0A232FBV7"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041388">
        <property type="entry name" value="FHA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17913">
        <property type="entry name" value="FHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNK FHA" evidence="7">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="591" mass="67291" checksum="8A4E53FE0E406223" modified="2017-10-25" version="1">MSSDTKSCYICSENKSMPPVYLPDKLEVFVGRSVDTKIADPHCSRKQVRLYASYEDHKVSVEQVGSRACGLNGFKTERGVRLVAQHGDRLEILYGKHPYNIEFNPAPKVNTESEKPKKRLLSQESEEEEDEAQSSKKSRMSEDGNGDKVSMEEDESVEAASTSSSNGTVSKSENGTWEHYSNKTLYVYTSNGCTGRSKIAAYDMDKTLIKTISGLEFPKDCNDWQLLYPEVPGKIKKFYEDGYKIVILSNQGNLGSGKITLKDFKKKIEKLVKKIGVPMQVYLAVGQSIYRKPRTGMWDFLVHQKNDGISVDKEHSFYIGDAAGRPANATRKKKDHSLADRLLALNLGLTFHTPEEHFLGHKQASYNAPSFHPKEASKNTVLYEPSDSKLVSDKQELVIMVGCPGSGKSHFAKTHLKNYYYINRDTLGNWQKCVAKTDEALAQGKSVVVDNTNPDKVSRSRYVQVAKKHRVPVRCFEMTLDKEHIKHNNMFRILTDPTHQAISDMIINSYIVTKSQLARRCLRFMHLLLLLCLRFYIRYSIRFSKSLPTSYRKNFTPPSEDEGFSEIVKINFVPHFKSEEDRRLYEMYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCE7</accession>
    <name>A0A232FCE7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_015851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000494">
        <property type="protein sequence ID" value="OXU28007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCE7"/>
    <dbReference type="STRING" id="543379.A0A232FCE7"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="440" mass="47281" checksum="4F7C63F09F6572A6" modified="2017-10-25" version="1">MEKELLLHEAVISNEAETYGRAPIHLAASRGNIEILNLLIKADCDVEAKDKPLDPFSLSNFSPFTLVPAKFGMRALHMAAWYGQQDAVDVLLDAGALASALDKKHRTLLMMAARSSGCGESLLEHILSRANLDPAIEARARDCDGCSALHHAARAGETRAIQTLARILPELEIEARDQFKIETLFIPDIRFSTNQIALLTATQQPRGQTALHYACAAGQQEAASCLLELGASARQQDYEGNTALHLAAANRESRLFAWLLSRCAAGVERTSLLRTADRRGYTALHLAASLGCSLILGDVLAELEREQQKPQALASRCLEGNTPLHLAAQMNQPQACDMLIDAGASLNALNTKMQTPLQLATEMGHSHVCRLLVAASEPNNVEASAAEGGSGSQQEGTALQVAARTSLASIANIIARTARLDYPAMLIKGTRALFNSPEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCV5</accession>
    <name>A0A232FCV5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000428">
        <property type="protein sequence ID" value="OXU28462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCV5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="13326" checksum="B3D5C7FB44534656" modified="2017-10-25" version="1">MAFSIEVLQCKSKLNNLRTRKFMKKTFYPEMMPRENEPVLLKTTHNLMNAVLSAITKVRQAMGQSVDAQRINEADIVDFESVVASEDTNSDGFIEVNFTKETDERSEETEENEKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDD4</accession>
    <name>A0A232FDD4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000374">
        <property type="protein sequence ID" value="OXU28814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDD4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012466584" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9683" checksum="B55C9A5A507C2C54" modified="2017-10-25" version="1">MDNDSRYKDHQVTSYFLLVLLLIAKVSSKCLFSTAPIYLPHLDCEKFCQCINDGQVVVQSCPSILRWNVQPETCDWPANVQCSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDQ4</accession>
    <name>A0A232FDQ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000357">
        <property type="protein sequence ID" value="OXU28924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDQ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013122071" evidence="2">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14102" checksum="C092A72673218ED3" modified="2017-10-25" version="1">MSVSVNTISLCGFLLQLFAIGLAYNPLPLETMVRPIYWTKELIDRIPYDTVFSDEIGPGIRGTPKLWDEYARIKASKPNPPYWKQPGFYESQGPPPSWFTATAPPGLAWNPQSPPAQGGWPNIDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDQ6</accession>
    <name>A0A232FDQ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_002701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the muscleblind family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000375">
        <property type="protein sequence ID" value="OXU28805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDQ6"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF12">
        <property type="entry name" value="PROTEIN MUSCLEBLIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="567" mass="60292" checksum="53C3234BEC039CCB" modified="2017-10-25" version="1">MQQMGLSPGQPLVPGQVPTVESQPPAPSHQHLQQQIQQQLLATHALMATNPYLPGMPQVGNTYSPYFAPSPIMPTIMGPDPTGVGSPLGVVQQTVAMPQKMPRTDRLEVCREFQRGACKRGETECRFAHPLETVQANEDGSVTVCMDAVKGRCNRDPCRYFHPPLHLQAHIKATQSRASIATAQMPIAGAVSANAVPGGLQNANMASIELGKKRMRDSNDDLLMMDMKSVGSLYYENFAFPGMVPYKRPAGDKSGVPVYQPTGATTYQQLMQLQQPFVPVSCEYTGTPPLPGSQNSNQSVVGAVQNSIQSQASNAANSEAAANGILVDPNNPPPPPPSSATNDKQSANANHESESSSAVGQNSHELNHSGSSSQQQQQQQAHQAQQQQQQQQQINQQIHHALSAAAAHNASMNAITSMAGLSSVPNLVSANSMASSIANLNSINNMNYTMANMTNINVLNSLGMPSNLSFDPAVLAKEVAQKNYAKAIKLSQQAAANQQAAAASYGINPLNPLNYTGVALNKQTLASLGQQPGAGSLPAYCYRSSESIKRDSKLALGDIEMLGILDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDS5</accession>
    <name>A0A232FDS5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000407">
        <property type="protein sequence ID" value="OXU28609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDS5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="11885" checksum="11C12E991F0EC22C" modified="2017-10-25" version="1">MLPNQQHIQQEDKASQTIEASNAATTKTLNKRKAMPLSKLEKQQENYAKNTRKVKKGASVEIASKLQLQVSSEGKADPPWQEIITRKEKKKENKRKKEITKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG54</accession>
    <name>A0A232FG54_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000247">
        <property type="protein sequence ID" value="OXU29734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG54"/>
    <dbReference type="STRING" id="543379.A0A232FG54"/>
    <dbReference type="OrthoDB" id="5912242at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127334" description="EB domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="248" mass="27466" checksum="534B6E1642C55EF2" modified="2017-10-25" version="1">MKSVICVVFLFVLSIRADTYLSAIPCRNDQGCNRVLAQPSRPICLNGICMCPNITTKMYQHCSNKDIVVSARFNGEDRRCSIDMDCKHIIGAKCFKSDKDIMELGTCDCQDHMVLSDNNQRCLKIANEVMDKCNETIQCTMGLKGAECNEGICRCWADHHYAYTKKQCIPNKAYGEACTHDEESCYQLAAPANVNALGCSDKNVCTCRKNFRFVGGICQASGYVASATRTVIQLLLVAATALFAILMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIC5</accession>
    <name>A0A232FIC5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000199">
        <property type="protein sequence ID" value="OXU30057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIC5"/>
    <dbReference type="STRING" id="543379.A0A232FIC5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="311" mass="34950" checksum="B854D578230A46C8" modified="2017-10-25" version="1">MSLPSECKNLHRKKLGVCGSIDTGTAGREHREHAAARCRIPTSFRCLRKVEDFVIGNKIMKSVHLDFDLTHSIGEHILNTILQIEAEIGKRITFAKMKNCSIYCAIWLNWQGLNANDIAFVCSKNNIDLYAPIFGTFYAGGIFSGWNPFALSLSNAKQTAQHFMNLFKPKFIFAGEAVVDTLEKAAKMENVHPKIALFGKHSNFQSFFDILKLPTEEQMHSFRPQKVENPSNSALIVDCTLAIRVFMTKILERLKEVTETELVKLSISVLGELKKLHAGVRFLKEIPKTSIGKINNRLLLKAMAKEMAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIG6</accession>
    <name>A0A232FIG6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_004176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000195">
        <property type="protein sequence ID" value="OXU30087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIG6"/>
    <dbReference type="SMR" id="A0A232FIG6"/>
    <dbReference type="STRING" id="543379.A0A232FIG6"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU30087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10100" checksum="3728631C240F9F5F" modified="2017-10-25" version="1">MDSLGSSLSGLTGSQKDELMEKVKQEIALANFQELLTKITEKCFKQCISKPGTSLDNSEQKCVAMCMDRYIDAYNAVSKAYSSRIQQERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJF1</accession>
    <name>A0A232FJF1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000132">
        <property type="protein sequence ID" value="OXU30670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJF1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353294" evidence="1">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="9274" checksum="D606F870AC1D1BD5" modified="2017-10-25" version="1" fragment="single">FIALLFRLALPYNAVAVVPLTHKTVGLRQTVADGRPQAQLSLLEAPDGRPWVLPSSPPGLLNLVAAGFLGSSTHILLAALVLPLMVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKF0</accession>
    <name>A0A232FKF0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000101">
        <property type="protein sequence ID" value="OXU30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKF0"/>
    <dbReference type="STRING" id="543379.A0A232FKF0"/>
    <dbReference type="OrthoDB" id="10006996at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF31">
        <property type="entry name" value="SIDESTEP II, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10161" checksum="5F2889C9EA740118" modified="2017-10-25" version="1">MSNFIDIHRVVPETLRVDVRGKPLKQARHQSPSFGQRAYFRTIQEPAVLALDEIKRHDAAIYRCRVDFHRGQSRSVRYNLTVIVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLC1</accession>
    <name>A0A232FLC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_013257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YY transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000050">
        <property type="protein sequence ID" value="OXU31541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLC1"/>
    <dbReference type="STRING" id="543379.A0A232FLC1"/>
    <dbReference type="OrthoDB" id="10264072at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000104">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000109">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000163">
        <property type="entry name" value="transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000174">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU31541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="304" mass="34274" checksum="ADCC41D8D4E35343" modified="2017-10-25" version="1">MLECIRSVLLASHLVDVPDEGSNPEPDPDYAEYMSTKSSVSMVNHSGSSVSDGMPGLDLSDPKQLAEFARPGHKLKVRKPPIIDGVERTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCSKKFAQSTNLKSHILTHAKAKTRNAIGRQVQQIQLQQPQFVQVEVADVDNQQFIDSESRQRKPDLKDLHMTSSSLSRKEMSDDYYNLSVSSLRGKNCEDLDCVFCFVSFTIRFLLIKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLN7</accession>
    <name>A0A232FLN7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 267</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLN7"/>
    <dbReference type="OrthoDB" id="10014558at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026572">
        <property type="entry name" value="TMEM267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13628">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13628:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU31368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="204" mass="23155" checksum="BA9500D01EB3FD78" modified="2017-10-25" version="1">MLNYRQGLLVRVFLTGLIGLVSFVGDKGLQNGKSEIVRAISDNLTHATVGGITWTLVLVLSKKSVVDNLGSIVVCFFMSSLIDIDHFITAGSFDINDATHLNHRPFLHCTTIPITLWIIMSLTSKIANIPVLITYAWMILASFISHHVRDGNRRGLWFWPFGSTQPIPYYFYLTICMLLPYFIQWIMEWQLTKETEGLSFVNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM88</accession>
    <name>A0A232FM88_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10295" checksum="8E44D6176F91AB51" modified="2017-10-25" version="1">MASIVEIFEVISYIDGGTRPFEEGSRIVNANHVLLCGHSGVKQXGDFLSLYTVCVLAHWNGVGGVPVCLYASMPIAYLLLCNYQYQQYSTLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FME0</accession>
    <name>A0A232FME0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000042">
        <property type="protein sequence ID" value="OXU31618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FME0"/>
    <dbReference type="STRING" id="543379.A0A232FME0"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="84"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="884" mass="99954" checksum="2029646261258001" modified="2017-10-25" version="1">MAKANVETSGLRLRPNTVEENRTVLREIQTRKEVDARKQDELNALFDRINAECASRSLKEKKKLLQQASSAEKLLEKVNTVHYGPLPGFPSGTWWGIRMDCSRDCIHEPFNENIHDGPYGAVSICTSHLNAHNDVDFGDTLTFTSREYSATDQFKDSLILSYQNRVPIRLVRSYCLSNNYAPKTGYRYDGLYTVVDHWIGVSPDTTKHRKFVLTRVLDQESPTWAERISGRVKKSVTPRLTRSQKVVRTQEPKATKFTYKKVEVEPKVGSVSAIVSRQVFNKCIPGSPDSSSKSVSSTDSQTYCHNTCPTKLCNTNLSIRTNLYDSSQKLQDVKKATTMTLCKIIKPNQTTQLVQKNCQEDVEKINTDLSDTEVMNKNLSNNIEQESTEKKIKKVTWADSCTSTSSSIEKSVPTAGNGFQYSGSDVVDGFSPTSPKKCGVLKYNNVAETTSPPKMPRTRPNILRNSSTRSTSQHVVQIHSRSNAVQTNFSTKSETLSKETEQSENKPSSSSIDSLAPDKLVNMIVKEKYHPMAKLLIGNMIGLENQESAILSAYNTLSSKVDQDDSKTSSKESKLRSFYISNKSRKNGMLKKQQRREIANLIIDAKFDTGTRSSRNRRLRSIKRRLSKSEISQRKLMNARRIQSRPLNNKEIRSTTAREAQPKKPEKRKTEEIVVPKRSKMVSTSTQCTLLKAPAVDQAIQTGIIDTSPSESEIKVEFVDLDDIKSEPCDVESNCEDVNIEIDTNPIRRAHFCGSAFAPVNTADSGYRIARLRSIGFRPINSCSPMEDEDSNQASSRPDVDEEYNKYTSEETDIVGYMEEQLHFEDIEDEVMEIDPTEQTSQKRIQKKLCSPKPIEFLLEEDFDKPWHGWKQISVDGRLYWSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMY1</accession>
    <name>A0A232FMY1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000035">
        <property type="protein sequence ID" value="OXU31727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMY1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="118" mass="13687" checksum="3F725C4942EBB1C0" modified="2017-10-25" version="1">MVRKYLKDIPNLDLDKIHVRRFARSTVRSYIAPIVVRFSTSAEVIRVVTYRNQLPQMMSPALDFTPFRRSCLRQLLAAASKHNTAHLDKSKARSGSNKFSDMIVIYVLLVCLEEEVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN14</accession>
    <name>A0A232FN14_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HSac2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000006">
        <property type="protein sequence ID" value="OXU32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN14"/>
    <dbReference type="STRING" id="543379.A0A232FN14"/>
    <dbReference type="OrthoDB" id="10012704at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040242">
        <property type="entry name" value="TPRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108:SF1">
        <property type="entry name" value="HSAC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU32126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="267" mass="30451" checksum="B82BEB226A56139A" modified="2017-10-25" version="1">MDDTFLQDEGPTFDRATLELKNENSDVLESENVKDSNKDPLNGTTRGAPGISVPGIPYTRIDCHTFFSDRNEVVERALADCQRDLLSSTEEEELVGTWLLTEISIWDTEKERLILLTKNSLYTVKYDLISLKILEYNRVSLSDIDTLIAGELIYPPTSLLPSRNMFGIRLMWNKGQPLSMDKKWNPFARNIPWLTFTSHPLFWHKGSDSDKTKYDVHALHTALKDLLESPCQKIENPIIIENYVGIGSLVHNRTGLGFFKIRGKVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN91</accession>
    <name>A0A232FN91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000006">
        <property type="protein sequence ID" value="OXU32105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN91"/>
    <dbReference type="STRING" id="543379.A0A232FN91"/>
    <dbReference type="OrthoDB" id="6481667at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF92">
        <property type="entry name" value="LD04844P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="100"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU32105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="265" mass="28975" checksum="D79D383A0E28D885" modified="2017-10-25" version="1">MSHSVTIQTRTVTTGSPSAINTTFCRSWTGILKLAQVVPINRYYNNVNMAQILGAISVGLSGYALSQYNSTTIENLFFLLIATTFMISSFILVLSYLCSYTTESIISKTVFELLFHAIAFALLLAASVTLIQRVSNGYYKQDKLQLGASAVGIVIMSLEVDAINDQFLGSGDIFLMLMATAFMIGTAIFIISYIFSPVSEAIIGKTNYEIIYNSFALFFIMIASIVVLAQESQREFGRRMVSAILGIVDAILYAGNTAMAVKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNN7</accession>
    <name>A0A232FNN7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_002970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000006">
        <property type="protein sequence ID" value="OXU32129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNN7"/>
    <dbReference type="STRING" id="543379.A0A232FNN7"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="181"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU32129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="405" mass="45746" checksum="BA15978D68FAE6B7" modified="2017-10-25" version="1">MTLTNKMEIDEKTSKGEGFKPYYIQKIEELQLIVAEKSQNLRRLQAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNIDINDVTPNSRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED59</accession>
    <name>A0A232ED59_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01008288">
        <property type="protein sequence ID" value="OXU16284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED59"/>
    <dbReference type="STRING" id="543379.A0A232ED59"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="289"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU16284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="69207" checksum="089B376C2ECD651B" modified="2017-10-25" version="1">MTHCIAHPDIMYYFIFKEEALQAFTQRVILDGENEYFCENCNKKCPAIQDFKFVKLPFILTFHLKRFQYDVNSESNIKLNNKVIFPEVLNLNSIIDSFEEKNDAEDSYFYELFSIIIHSGTAVQGHYYAYIKDLERNEWFCFNDSTVTHISKDNFKIAFGNGNTEVGNAYLLVYRRSNELLRDTAIAQESSLDVNLAKQQPTFININSIDNCINTDTTIIEDPSSDISLKEQTTPFSHDSFPKLTHLKDRMRKKLKLHNANTDSENHVLCNSSQKSDCKVKYIFEQDAILPIDENIEVLSHVELDQSQPVVDSVSNLSVDNLSLKEVSNDVLSIRSSKSQRSQSIVRSVQSVACSSEIFNKKATQESEFRSQTFETKIDKKQKRNIAIPALNDAPDTTLLTYPPPPYKGGIDIKYAHLKCLEDGVYVNDIIIDFYLKHWFLTIICYPDVIHDKYVSSHEKPKKLKLHHESNDNSLITETKTPCILVFDSAPGIIPINVGNMIVEYLYWEYKLKKDSTIKLSDFDVKCVYPEVPQQHNAYDCGIFVMQYVEHFFSTSIVDYSLIPSLKEWFAVKEIRNKRQVILELIEKKANEQKYIKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED98</accession>
    <name>A0A232ED98_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007411">
        <property type="protein sequence ID" value="OXU16316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED98"/>
    <dbReference type="OrthoDB" id="6751099at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="24330" checksum="71EC78131FECA4EB" modified="2017-10-25" version="1" fragment="single">CYTIFYHRKLLIFVTIVGSYKNRNKKICDLLKIRETCQKRIHVHRGKHECGILFCKICGSRHSTIAACYMQIVRAPKQLKESKKYLYVFYHFYTQQDTLYKMRADKRLHTPNLCVVQHLCTDCLTRADDMKIRCDTLGIREHIFRENAIKHLIELYVREKSVFERIICIAHNASGFDAQFILKYLVEECENANPRVVLNGKNIVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDF0</accession>
    <name>A0A232EDF0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006513">
        <property type="protein sequence ID" value="OXU16381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDF0"/>
    <dbReference type="STRING" id="543379.A0A232EDF0"/>
    <dbReference type="OrthoDB" id="6776074at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10554" checksum="4123B18414D8807A" modified="2017-10-25" version="1">MEGGYQFLKSSKPNELVSVDFFGPLPRSIGGVQYIFVVQDVFSKLITLYPIKRATTKICLIKLTQNYFDKVGKPERILSDHVTKVFRNLQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDG4</accession>
    <name>A0A232EDG4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006671">
        <property type="protein sequence ID" value="OXU16373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EDG4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="513"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="756" mass="85366" checksum="7385B85DD446A450" modified="2017-10-25" version="1">MDEVTKFISKELTKFRESIKSTVANQISPKSSQNSNGPNNNSNQQGDGQNSNQNNPQNSGNNNSRGNKRYSNQYRGRNNNNRGYYNNNNNADGNDPNNDNNWRDHQNDNNSQNNRGDFNNQGGYQNAGNRGGFNNNRGKGGYNGNNANPKPNQNCGPPTNAIETEEMENEEWAAVGNTEFKALIDLGAARKIIKKHGKEIARRLGVDIKPTIYKNAVMVNGSPKPIDGEMTVPLEIAGVSKRAQILVIPGIPTDFILGIDLVRLFGMKIDARRDTFKLPDRKDKKEIAFEVWSIDTCDSPINVASLGLSQISASEQQQINNLIYELLPRVGQHDKILKTTDLVKYIKQILPNVANSLSKNDAYPLPYMDVILNKLKRAKYITTIDLSNAFHQIRLTVASQETTAFTIPGHGLWQYRVYPXVSKRAQILVIPGIPTDFILGIDLVRLFGMKIDARRDTFKLPDRKDKKEIAFKVWSIDTCDSPINVASSGLSQISASEKQQINNLINKLLPRDGQHDKILKTTDLVEHEIQLLPNVKPVKQRYHPVSDKKQKIMSEQVDKLIEAGIVEKSLSAWNSPIVMVANSLSKKYAYPLPYMDIILNKLKRAKYITTIDLSNAYHQIQLTETSKEITAFTIPSRGLWKYTRLPMELSGSGATFQRLLEELISNLEPYAYNYLDDIVLATETFEEHLRMLRKLINRITGTGLTINSDKSKFGYKEVKFLGFLVNEKGLMIDPDKTEAVRNYPSPRTLRQLRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDL1</accession>
    <name>A0A232EDL1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006262">
        <property type="protein sequence ID" value="OXU16424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDL1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7142" checksum="0A8871E31782BF36" modified="2017-10-25" version="1">MLNERDLRRYTALQGPGVGPSYNRDPVIRQHQPEQPRRVSFSPALRPRQINQKTGLTTSVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE67</accession>
    <name>A0A232EE67_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005596">
        <property type="protein sequence ID" value="OXU16612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE67"/>
    <dbReference type="STRING" id="543379.A0A232EE67"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="2">
        <location>
            <begin position="319"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="439" mass="50415" checksum="3CF61D6542BD363C" modified="2017-10-25" version="1" fragment="single">NDILQLWQEAIPINGSSLRKHHRVFELHFKIEEVNKTFVHTLPDGKTYTLLKDKCSLKKGSVPSIFPIVAERESEVKYPVDAPRSFPPITTSPPACCSKEENGIDHSGRYLEKDEIAQSSFHPIHTASNSSTVEKITSNYMSVQIQNATAKSIEELTNYEKTNYSVSPVTSTIEDHSQQSSRFDEYSNTLHESICPPGNVQFQQICNDLMKNPQSIPLPAAWIPQVITRGLKCIMWTEWKEGYRAIAKRIVLFSNMTFNVSILLVDEMKLSKSVSFNRQNLKMEGFTDLGIYTPKNQQGQKGDHALVIMFQPFKGKWTPDGYVSLKHWFALLAIENPKDYNLKVNYHLKEEHINPQYYQKMNVALAFQFFGVADSMELLQDKYPDLIDCNGSIKFCRRMKSLITAMNSRTPLNSLKPGNDMWKVFFNFDIFLRVEYIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEU1</accession>
    <name>A0A232EEU1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005222">
        <property type="protein sequence ID" value="OXU16867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEU1"/>
    <dbReference type="OrthoDB" id="7697589at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="13967" checksum="2BFF6B5701F74146" modified="2017-10-25" version="1">MDAGDQLNQDMESLQTHIVKSNLETLHQKLNDAQITLHKQHLQFLRLANRMNPLDNFVNRTVQILPKWIEFKYQFDQSLEHSINLYNSCEYHRNNYARSLTPTVFLYTSNLNIYLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEU5</accession>
    <name>A0A232EEU5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005212">
        <property type="protein sequence ID" value="OXU16880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEU5"/>
    <dbReference type="OrthoDB" id="6772810at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="218" mass="25375" checksum="CD2852C2D2A4B100" modified="2017-10-25" version="1">MHATVFTLTEILAKEKGIQLNQQKQLSIFKTITSNPRYHTIIPANTTGTSKYFFLHSPTIQTSTATHPYTKVTKVIRKLLTQLSTRHEKIWIGVEFLQRNCRSLKEKAYELDSLLNNYNDASSRRLIIFLFVIKIQRIQNFNHRNKNSQRNHHDFNKVVICGDFNAHHSMWSAGKEDHIGKHLGSEITYTNLIILKKIYPPYPLILSTKQSGLCWEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFF0</accession>
    <name>A0A232EFF0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005035">
        <property type="protein sequence ID" value="OXU17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFF0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9541" checksum="4D60CAC188D50E6C" modified="2017-10-25" version="1">MLEASKLMILRKGFGDPINGYIDCFSFILCRNQNPACFLGSCQKCGNFLRFEEHVSSVLYKNKIEELIFSVWQSRNQCILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFM1</accession>
    <name>A0A232EFM1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor BTF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004979">
        <property type="protein sequence ID" value="OXU17143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFM1"/>
    <dbReference type="STRING" id="543379.A0A232EFM1"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="3">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="266" mass="29098" checksum="3E1ADC11C3EB78FF" modified="2017-10-25" version="1">MSAHTNTSIFLCVFSRRSLGPTTEHVFGSLSDRRCRAHRTESPFIRATVVPPSLRASRRIVCFFLALVQSKLVPRHLDIIMNPEKLKKLQAQVRIGGKGTPRRKKKVVHTTNATDDKKLQSCLKKLSVNTIPGIEEVNMIKDDGTVIHFNNPKAQASLSANTFAITGHGENKQITEMLPGILSQLGPEGLTQLKRLASTVAGSGVSKAALEEDDEVPDLVENFDEASKEEVALKKEADEALVAEDKKEAAKVAEESKDAPLAKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFX1</accession>
    <name>A0A232EFX1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004925">
        <property type="protein sequence ID" value="OXU17234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFX1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10704" checksum="084E11F1791B39A1" modified="2017-10-25" version="1">MVQFWHSCGTVLAQFGIISFTTIIYSIFVHYITVWRNIGTVFLDIGLVWHDIGTVFLDIGLVWHDIGSVWRDIGTVWYKSTHSSIRYKILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGG3</accession>
    <name>A0A232EGG3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004770">
        <property type="protein sequence ID" value="OXU17436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGG3"/>
    <dbReference type="OrthoDB" id="8113373at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31883" checksum="486C16608EEBC060" modified="2017-10-25" version="1" fragment="single">FNIKIVQTLPLSISSRQNKMKILENAEDWKQQDELLKVWQHHGVEEQMNDGTTKRVRIVIQQIPGNRYDEVIQHMLKFFLAEADICVSWKLKECKDAIEDYRILWKYCLNANMSVGAFKLGSDDSLLELIAVNILYVSTHEVNKDLENIVSNFKCLTMKKIYKLKHDIWKIVDINKIYGIDRYISSSGLSVSPPFRGQKLGFRLIEARNNIGRKYGIKFTSSMFSGLQSQIQAQRAGFETIYMLNVEEKLENDSKAQFQEKKDTTTKIMIKQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGN6</accession>
    <name>A0A232EGN6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_001318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004721">
        <property type="protein sequence ID" value="OXU17520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGN6"/>
    <dbReference type="STRING" id="543379.A0A232EGN6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU17520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="186" mass="20740" checksum="A91B2548123BD08C" modified="2017-10-25" version="1">MNLDYDSDYGERSIYIRTGSTIRGKGELFKVANIIPETLKSTVLPVINSTDCNTKYKKVYPYQRVVITDNVFCSFKKEEDTCHGYSGGPAVIENQLVGFISRGYDCGGASGLHDVHTLLRNLQEYLSLPGPPPGGRGIVFCSTVVQSYVNKNYLRLMNTLMKNKQMLLIPSREPFTTDEAKPTALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGR0</accession>
    <name>A0A232EGR0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004705">
        <property type="protein sequence ID" value="OXU17528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGR0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7525" checksum="9C4209E218A17A49" modified="2017-10-25" version="1">MGSESDQSDSEVDKNLYKYILNFLASWSFACNGLKIWILIIITTNIDIKVCSMESSRAKGTGHMPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH38</accession>
    <name>A0A232EH38_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004594">
        <property type="protein sequence ID" value="OXU17676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH38"/>
    <dbReference type="STRING" id="543379.A0A232EH38"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="193" mass="21745" checksum="F58B6B0504CA2DA7" modified="2017-10-25" version="1">MYKLKFMRSSRKPLEKCTPDHRARMNRLFERARQECSNNHAEAISAERTSANASVFGTSDINQSVRSIADSIDEVSNDTSFLHGDMTQPEYDNSIEPDDHSITDSEHSSVATDFDNLEAFESRLARAFTECNMSHVQSKCIIDVLRTHDCFRNMHKDPRTILKTPAHATRTSNVGGGEYLHLGVEQGLLEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHK2</accession>
    <name>A0A232EHK2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004513">
        <property type="protein sequence ID" value="OXU17798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="806" mass="93709" checksum="61CC99179FE63B4A" modified="2017-10-25" version="1">MCVSQNRCGILSKLKSNLLVETSQELHEESLLKKDSIPSTHNTEEKLINLQKINIYPFSVLQWSIKALDIVLSLPRDIQFIFGVVGSFCENFVAPDGSISQQLLLHALGVNVEDEFIPISQITMEQVTSTSLFNRFFSICVKNGLFVPRRIKDEFIPISQITTEQVTSTSLFNRFFSICVKNGLFVPRRISVDHIWNHYTAVNSVFNVNLTYEKYLLKCFKYLQGIDKELPCVIHTNVRFLIIEIMHWKCIINSVFNVNLTNVITNIENEFKEIISSENVQKVDYKKCEIIINHIKYIFVKVKECISILDQSVHNPKYCERNVFYSEVFCKHLIQLCTEFVIWSKVIYVGADELCTDDPLVTLIDNYKNEFKNCLLGSKLTVDEYLMKNIDYTYLMKNIDYTDEQLKILRNFIPKKIECNIKRLNENRSDFENTYLLYEENWMGQNPQEKLSCNDDSDTSSKSYTSESEEELDYDLDVQDNNEIQFAEQSIDEIIDSVCEELKNENLNEEPCAIKIVENKNLSKIIIPLKQKKINKTRLSVLTSSFFDSILEILTSVYFXIDEIIDSVCEELKNKNLNEEPCAIKIVENKNLSKIIIPLKQKKINKTRLSVLTSSFFDSILEILTSVYFIINEFQIFIDNSENIFEGIKQEFFIILQLTADFLSKVCIDQHNYKLCWSQPIGDFVAKVMYPNIFLKALCLDCDKFVYQCSNRIKLSSEELMSQNLGNEIYRKLQKESQIPCEECKQLLILYELEIKNLLCIDVEECYTNIQNCLVQLDNLNVYLTVGKQKLTLVGVVAYKKNNFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIT3</accession>
    <name>A0A232EIT3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004166">
        <property type="protein sequence ID" value="OXU18255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIT3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="145" mass="16741" checksum="3EF0FC81FCA61D35" modified="2017-10-25" version="1">MNALNWEVEDYVASKTNLIEDIDPMKSLANIYSFTTAHNPKTGILRSTYMRNKYYKQKFHYIQPIRVAILDDDKSETQHFFTYVPILETIQSLLMNDNVQPFCINQRKSSNSNSLFDVNDGNVIKNSNFFNVKNIVQIGFVSGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ14</accession>
    <name>A0A232EJ14_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">trypsin</fullName>
            <ecNumber evidence="9">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_009934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01004111">
        <property type="protein sequence ID" value="OXU18357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ14"/>
    <dbReference type="STRING" id="543379.A0A232EJ14"/>
    <dbReference type="OrthoDB" id="10051896at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF97">
        <property type="entry name" value="GH13245P2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0222">Digestion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144660" description="trypsin" evidence="10">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="49"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU18357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="289" mass="32145" checksum="49646E42374032D0" modified="2017-10-25" version="1">MFYHSQTIMEKILCFVLSLAIVNCFELGFSDEPESKVFGDKDDSLKSGIVGGEFTEINTVPYLAQILEDGDQVCGSAILSEYWIVTAAHCLEDDGELSLDTEKWTVITGSSVRSKGGHLHRVKKIIVHENYVSLTSDNDIALFELEEPIKFDELQQAIEISNRVPKAGDKLKISGWGKQGERRGVSKQLKTAVVPVIDETECLQMFEEEYLGYEDYRESEVTNNMFCAGANGEDTCQGDSGGPAVIAGKLAGVTSWGFDCGSKKTPGAYTRIRNYRQWIAEHTKLKIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKH8</accession>
    <name>A0A232EKH8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003811">
        <property type="protein sequence ID" value="OXU18821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKH8"/>
    <dbReference type="OrthoDB" id="7699518at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="209" mass="23958" checksum="FDC69AA94745A6CF" modified="2017-10-25" version="1">MNFLESLGGKKQPAPIHHIHRHYYPVPLPVLLPKPAPPPKIEIDLTSLHRYDIRAFVESTRIIYLRWGGDIFSGHDSLRSLGWSSQDYGKIYEPEIVVPSEAPWVSPLPEAWPDTTGRKSWGWENNEILEKDHAYKEAKPPGILLQVPLRQQIVLYQPPAKDNKSTLLSTLLKKIRRINDALFHPEEEDCPQPHDNKPHITNSLTYSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKI7</accession>
    <name>A0A232EKI7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003792">
        <property type="protein sequence ID" value="OXU18863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKI7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="476" mass="55078" checksum="256566122B04CF39" modified="2017-10-25" version="1">MDRSSLRCAQPKSPVLTTGFSVEKQCAIFEIKNVGILKANYTLGFMKSQKVMREDMLSDIFSKQECGYRKRFLLLFNDWKKQNCQQVVLPQIVEASHSSHTSLQNEPLVPDTSEQMEVSVVESNVDEGSVEVVNLAYDYDKLYPSSVIDFTNKWEALSPLILKYAKLHKKYTDFLQNLEDAGKIDLAALLCLSRILGTIVHKRKAATNPYGTTIEEVQNSFILLVESEEEFQRHQESRTQQSDTIGPYIVIIPKLQLNTDENREDNGLKMAVDLETELLHLTLSLYNNPLIPRNVIQIFIDSLIKFTNSIFSEFLKQEISKYFKPDDSVINILGISLNNSKTIFEKFSTEYLRFQMYEKKGLLMMPQEYCIGTKYNRIQTERGSTIEKEVFKAQYIPLKWSLKLLLEIPGVLDIIKNYMRDLESESNIIFNFTQANLWKKLRENFQNKFFIPLFIYEDDFETGNALFSSECSLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKX5</accession>
    <name>A0A232EKX5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003677">
        <property type="protein sequence ID" value="OXU19013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKX5"/>
    <dbReference type="STRING" id="543379.A0A232EKX5"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="376" mass="43612" checksum="86B1B83B8C6C6607" modified="2017-10-25" version="1">MFCSIIRNNGFNYLSCINCISPFKNASMTKSIYPMLMLQDKKLADLAEEQEIFDKSKKLVMNVRVNLSESESESIDQEIIESIPIEKVPYKEDQYQHSFNINRNHYKHIVGVKGTMLQKLCSETKTIIRVSKKKKHVVIIGSIQKRIIHAKRRIDNLIQSSNNKLSFTHFISIPTNVSEVQQHFLKFKEDVLINCDKEATGIDKDMFQKPEKLHLTICMLHLLEDTDQRKAIRALNACKKEIIDPILQEKGPLTIEFRGLKCMERNSTKAKVLYAKVQEETGQLQKIADQISKYFVQQGFSRKEHDNVTLHMTVINTFYLKKKKQKFMHKNFDATQILKDHENTYFGKINLSTFHLSQLTAKSADGYFEATAKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELB8</accession>
    <name>A0A232ELB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein uL18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">60S ribosomal protein L5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_014820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003579">
        <property type="protein sequence ID" value="OXU19159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELB8"/>
    <dbReference type="STRING" id="543379.A0A232ELB8"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="12">
        <location>
            <begin position="296"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU19159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="357" mass="40639" checksum="8DDBB92572972AEE" modified="2017-10-25" version="1">MRRETGSTSVRPLAVKPWPKLVREGAHAFAGNDERGRFLLRESRAAEGSPVAASSDFSAIMGFVKVVKNKQYFKRYQVKFKRRREGKTDYYARKRLTIQDKNKYNTPKYRLIVRLSNKDITCQVAYSRIEGDKIACAAYSHELPRYGIKVGLTNYAAAYCTGLLLARRLLKKLGLDKLYTGVTEVTGDEYNVEELDKGPGAFKCYLDTGLMRTTTGARIFGAMKGAVDGGLNIPHSLKRFPGYDNESKSLNADVHRQHIFAQHVANYMKTLEEEDDDAFKRQFSQYIKNGITADNIESMYKKAHEAIRANPEPQKVEKKEQAKKKRWNRAKLTLSERKNRVEQKKASFLKTLEGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELQ7</accession>
    <name>A0A232ELQ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003533">
        <property type="protein sequence ID" value="OXU19242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELQ7"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="698" mass="79574" checksum="062D11D22BBF6437" modified="2017-10-25" version="1" fragment="single">LIRRSVSFVFSITASAMLPAILLVIVATVHDATAVARNYEKLLAKEDFEDKFSLLGPRSLIKNHQTVASFFKDEVGQNYTCGRDLAILDEAITRRELWALKMLDASSKIPSGLLEGNFIDLGMFDECMGVKGEALGVEIRGRHCMYSIVLTSGNNSLPINPTLSICMPSTCNGSDIVHLFNSTISTIDRLKDLGITVASATCTPVDKEIWDTEFTVSFSILMAFIGLLLFCTLCDVILRQRDAGEYRHHVLSTLAKFSLIVSASSILSTRVREGNLPAIHGIRFLSMGWVVLGHEYILHFQGVNVNNLSILNWIQSWKSLYIFIAQFTVDTFFTISGFFMTYLFLKQMPKEKRFNVPMYYLHRYFRLTPAIIALTLLTVVFIPKMGSGPRWDMLMSVFGGNCREKWWPNLLYVQNFVQKDNLCLGHLWYLAVDMQLFWISPIILYPLYSKPKIGLAILFVFFIVSIVVPGAIVGINQYPTFSFIQNENLQLIKVLLTEVYEMSYNRAGPWLIGILLGFEVANNNRRLGKLTVLTGWLVAIGSFAFCTFGTRSFMEPSYEYNDVWESVFTAVSRPIWAVGVCWIIYACLHNYARPVSTVLSWKFFVPLSRISYCVYLVHFIIQLMHLSTQRTPNYFSDYNIWNAFFSDLIISIVVGFFFSLLFESPIMILEKMLFRRKRENVKESQRNLGSEDSKAYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELR2</accession>
    <name>A0A232ELR2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 185A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003514">
        <property type="protein sequence ID" value="OXU19295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELR2"/>
    <dbReference type="STRING" id="543379.A0A232ELR2"/>
    <dbReference type="OrthoDB" id="72976at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019396">
        <property type="entry name" value="TM_Fragile-X-F-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568">
        <property type="entry name" value="FAM11A, B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13568:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10269">
        <property type="entry name" value="Tmemb_185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40652" checksum="9105940100638D96" modified="2017-10-25" version="1">MSKQIQHQTFLVAMKQLMYLCILLFSKFLVHTCLMIFTALFALRLDGFIEWNYWAVFSPIWFWKGMVILGATVGSYVWWRHPHSRLEGDAYVHYKAMLITLALHLILLMFELLVCDKLESQRHLWILVFIPLIFISIVSIAVCIWAVKHDRSFELELFCAVNVLQFIFLALRLDGFVTWSWEVVFVPLWALLCLSLVAVLYAIVFAAVLLRTPQINARQRRTSLNSALAYTFLVVPILVFQVLLANKLDEDISLNYTTVAMPLLLSHLTLIFMSFGAKGGNRWWFGIRKDFCHFLLGLCPLLQEYGNISYQPRSAQDQPAEPIVFEKNEKNIKKIDLMKPVEPIISIDMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMQ5</accession>
    <name>A0A232EMQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003314">
        <property type="protein sequence ID" value="OXU19643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMQ5"/>
    <dbReference type="STRING" id="543379.A0A232EMQ5"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="512" mass="57233" checksum="7A894162CF5C0DB0" modified="2017-10-25" version="1">MQSVHLIDDSLDLHCKTHDAPNETSALIYQKTRKNGNTIVKESNFDSERKVSKSRILASQLFATFAVSLLMFTTGNTMGFTTIFIGELTKKNAEINVTLDALTWYSSYFFVVPVGSIVGGFVAQRIGSHLLFIVTAIIYITIWLVYHWSTTSKMILCAQVLVGLVNGISRAPIFSFIAETTQPHLRGTLTACSILFHLSGQFFTILLSGYVYWRTIALVNLIFPMAALIICSIVPNSPHWLASKNRIDDARKSLAWYRGWTTPDSIKSEIESLKKWNMTDNSSANVRNNGNYNTITRLKNVFKPYLHRTFYIPLATSCYIFFINTFGGSHTVQVFSAVLFTQVRSPLEVHSATIILNTLRFIGATSCLFTIRLLGKRKLLFFSVIGGGISFTFAAVFNYLINSNFIVSDKYIWVPTIGTIIAVFILASGIEKIMHLLNSEIFPSSHRSVGIGLGILAIFAITNIIGFITLYFIIPETEGKTLNEIEQHYAGTQSLKGKQKQDKKIVDDINLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMW4</accession>
    <name>A0A232EMW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003270">
        <property type="protein sequence ID" value="OXU19705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="8823" checksum="D78C6CD79F6504C6" modified="2017-10-25" version="1">MRTGQCYRGRSTTLAPAFFPSQPTLGPTDSNSEVSLSASSSFNHILGTHVLAHSGTQGCAARTLFNAVDPTLRVAGCCSDNLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENE8</accession>
    <name>A0A232ENE8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_009160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003159">
        <property type="protein sequence ID" value="OXU19889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENE8"/>
    <dbReference type="STRING" id="543379.A0A232ENE8"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="77564" checksum="BF0D84FE24508758" modified="2017-10-25" version="1">MSLKMKAEEAKVGGYQILTLLLLSVNLIIVAMSHVIGLFYKYTPEFYCQALQETAVGSSDAASTSALLQGSSSGGEHVTNRTYGCVPSCPGGYLFTGTRDNVRSVAMEWQLVCEREYLTRTATEVYYVGGLLGGLVAGILADRIGRLPVLAMCLYAQGTMAVALYVIQEYQLFLVFRGLQAFFVQGLESCTFILCMELFPAKFRTLIALVVLSMRAFGMAVLAGLSYAVADWRILQLVVSVPTAVTVFYIWLIPESPRWLLARNKLTEAEMVLDRIAHYNGLICGGSSSRASNSDESENKRRSEKPQKPKRKTRATVAADADDNTKSTDVEKSLEESENLLPADTEQAAHGQKRMIIFFTPFMCSYTAHKRTSAEEKNVEEMINMNREQKSDLPPELSMEEIDNASLMVLASASNEKAREGTGPSYLLVSREALSADKNPKAKAGMLARNFIKRFLDSKFIGPVCAVQMGLWFCSSTAFHSLVTLPNRLSAERHVSLTLAAGMEIVAFVVTFLMVSSRFGRRRPLCVLQILVGVAVLAVALLLISITPDGPTQKWLAYAKVAVVSVGRFSNIACFFILRLVVIELFPTISRGTGLGLCIAAEMMGGLLLRYLSMLNTLLPELSRFIIGLLCVSVGSLSLLFPETRHEILPDTAADARSLGKRNNEISDDPVVLREKLFSEDWVDAGNGIIVNFTDSKSPELSVLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPV1</accession>
    <name>A0A232EPV1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002878">
        <property type="protein sequence ID" value="OXU20395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPV1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="161" mass="18271" checksum="6DD77792A58F1150" modified="2017-10-25" version="1">MKTIIEHGIQSGMLSENKEAQGRISETGWTIDNVVSNAYNIHKSVETDLSAIMIQVKHLERRQVALKKRTKSLGLMLSKMKMSPNQQHIQKEHKASKTIEASNAVTTRTLNKRKAMPLSQEEERQENYAKRTRRDKEVASVVVTSKSQSQVSLEEKVNPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ20</accession>
    <name>A0A232EQ20_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002875">
        <property type="protein sequence ID" value="OXU20396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ20"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23151" checksum="92CC3FE795EE21CE" modified="2017-10-25" version="1">MDNRKLERIKALCLLVLSDLFKLFDEVDEQEEELIIKIATTLEKNILLPPQIALNFMYLVDNYPPVEFRKLNAKMYKFLEFERSVQDVPCAAIKSNLILSSSSVYQVDVTRGMSAAGGDAGGASKWVGSLYKYYTIYRKIVSRFHVGLTTAIRANRRVVFALFGARDRFIQWPDNPIDNCRFFKDLYGFPKVVGCINGTHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ82</accession>
    <name>A0A232EQ82_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002831">
        <property type="protein sequence ID" value="OXU20477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ82"/>
    <dbReference type="STRING" id="543379.A0A232EQ82"/>
    <dbReference type="OrthoDB" id="7699050at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="434" mass="48104" checksum="0A2F993A25F08AAC" modified="2017-10-25" version="1">MCKNVCDNDHYSVHATDSADEVLDSASSSSDESNDSYQENLEDFESRLAKAFTTTNMTHLFFKSSGLMNVFQPFISALKTPVVSAPTTSVARGEYLHLGIKTALLRILQATDLKLIPDILQVDLNTDGASLDKNSKIVMWPIQIRIPNIPGSAAEVVGKPSSAKEFFKPSVDELLVLFEDGLEFCGSVKVVDFRCLIADGPARAFALDHRGHNSTARCSRCWIRGVMVYEGTVFVARTEEEYLSRVDILHYKGLECPISVLPINQMSSTVFDYMHLDCLGLIDGKLSKSAKLSSAEVQVLANRLEKVKEYCPDDFARKPVNVLKHGKFKATEHRQIQLYSGPVIFYALSSASCSNLAYNVTVLLILAAPDLQSAIYANNEYDGAIGPQLANKENLFEDSDTIVVEGRTMDEFENTQLIYQGYEENRGVYGIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQP3</accession>
    <name>A0A232EQP3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002739">
        <property type="protein sequence ID" value="OXU20661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQP3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="122" mass="13528" checksum="3971A7D2E561239A" modified="2017-10-25" version="1">MENPADVATRGAEPASLAPNQLCWSGPKWLALPSESWPVINSLKPSMFQRRLIRSQSVVWLQQLPLPWSPRTTSDSRGFLNSCESPSGPADCSAAGEIFRLQPHPHLSQPSSYSRRSMFAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER25</accession>
    <name>A0A232ER25_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neuroparsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002666">
        <property type="protein sequence ID" value="OXU20824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER25"/>
    <dbReference type="OrthoDB" id="5976811at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010850">
        <property type="entry name" value="Neuroparsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07327">
        <property type="entry name" value="Neuroparsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18187" checksum="9D4013D820B0E5D2" modified="2017-10-25" version="1">MARDTLYIFCMATLLLREVLNELAGGIKPAGGTATPPQPTQTVQVLVLLLLLNMLPMFLGHPTIIERAVQRSECEGCGANCKQCKYGSAFSLWCGLDECLKGPGEMCGGVRNKYGECGDGMYCRCNKCTGCSIDTLECFSGFCPILEQQMQLRHQDHSMHGLQLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERD9</accession>
    <name>A0A232ERD9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002616">
        <property type="protein sequence ID" value="OXU20933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="208" mass="22367" checksum="DB66435A5EB113FE" modified="2017-10-25" version="1">MESVVKENNITVQGRDTPVPTSTGENREKEAAEAFAIHCERVRSLLDFVLPRNNVHKEIKAMARAASKTLGEYSKLLRLGPAVTTPLGRRKNGGCQTSPIFRPNVPQNTGEHEPPPPPLPPAAKKRKADGDMHGQSKVPDWATVVKKGKKKKKKTKGSQPQQQQQQQRGASKPAKGTAEPKAGVRPPRPDAIKIKASNGGSSXSPGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERY4</accession>
    <name>A0A232ERY4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002530">
        <property type="protein sequence ID" value="OXU21128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERY4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="7305" checksum="7E6CD29BAB3ABD53" modified="2017-10-25" version="1">MHVFFWILNSGKTFIFYFFNYFLFYGQFLIFGKDYFAFFFQSSHQNYLLFLVRTSGSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET60</accession>
    <name>A0A232ET60_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the constitutive coactivator of PPAR-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002323">
        <property type="protein sequence ID" value="OXU21550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET60"/>
    <dbReference type="STRING" id="543379.A0A232ET60"/>
    <dbReference type="OrthoDB" id="10061469at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000009">
        <property type="entry name" value="Constitutive coactivator of PPAR-gamma-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026784">
        <property type="entry name" value="Coact_PPARg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15976:SF16">
        <property type="entry name" value="ASTEROID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15976">
        <property type="entry name" value="CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="108892" checksum="972D6FE7CDC5B5DA" modified="2017-10-25" version="1">MNIQALQLALDSNSVPGASVPVDLLKVARSIMQKQRNRNGKGQMLSNAKLRLVLDGECCLDRLYGGYFSDWACGGQWNRMIQFLEVFIQASKAAGLELAVFFNGSQESLRQAEWIQNQLSARQKVNNVLKHIATKGTPPPKIWWIPPACLRTSLRMALRHLNVTVVSSTDDHHQEVIAFCRENSYHGLIADDAEYAVFDPPRYFSSEQLKLTYKGSLDTKEYLISELLKGLNLQPERLCILAALLGNHILTESDLADFYKKINPNPNKINVDQSIRAIANFVKDLPSIELDDVAQQVFGSPTDPKCSIFKQSVQYYVNGTKDGFLHYKPIKPTKDEIQNDQIQSTTSDVPSTTEDETTNMSTSRFASETAESEQESLNVYKEATANAKAAPQIVIEPPASGVQGSADDANNSRTEEEQSNGHSAINGTHNLLISSSSSSSSSSATSPSHINVEQIKETDKSTTIPITVPEVMRTASERHQKGLMSPYIYQILANGEIKLPVLLEDENNKEFSSIHVIYRPVRQMVYAILFNLHHRLYLATKSKEKGETDKIEVSDVIVKEWVWSKSNPFQTPELVKAEQIGWGVPTIQRLWFGTGIDDKRRRLRGFLTCMRSDTPLMLNTAYVPQHLLVMACVLRYIMTFSDKTKILRRQELDAFIVQAFSPELMNAQYLQDLQISLVTTRGVQLASLFMAGVETALLANDACGAPIPWLMCCPWLYFDGKLFHHTLARATVAKNLLDLCGGNIDRDLKVERMRKAILEGVNVVFARPLPPITQGIRIAPPQAIPPAGCPITPDGLMRSRGGAVVGAPQRSLMRRPIPSRGGQLEIAGVVVGSWGPNFGQPGRIPQPLQGGPQRRIPPQVTSIGGPKYNLRPLNTLGVRPNISMTRGNGRAQAPSRGGKKTQMKVTSKKMDTFKKANYYEMKNGAGRKASNAVTSGLSNTFANLKLTKEVLKIQDQFNVSENGKGVVNGQGDAFKNAAHLVKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETD9</accession>
    <name>A0A232ETD9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002283">
        <property type="protein sequence ID" value="OXU21629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETD9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12263" checksum="C0E5AB55CE363B60" modified="2017-10-25" version="1">MHRYHDVVTNNTRKSQKRLFSPLRIATCYAFRDIDDAPMRIFLNHMCGGRVASLSQPIEKESTSQAQELFYNRANYATAAYPTQRNVSVYESAIAIRYSKIKKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETG8</accession>
    <name>A0A232ETG8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002279">
        <property type="protein sequence ID" value="OXU21642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETG8"/>
    <dbReference type="OrthoDB" id="7610567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="352" mass="39841" checksum="3AAB3AF15355752B" modified="2017-10-25" version="1">MKRSSQAEGSSNPGKFNERLQSDSLRYLDSGDGVQANPPHTRRFVDNRQPECLEAGECAAYHSHRSAPRQSGGGPSLHAETQRSSQVSSNSSRALQFTPEMIRDQELLVTSMNQQGIPETLIRRQFERLLDEQSKQLRLSGDNSKSAEANAPRVRRNNSTEETRLDNQTPPRTSRLEPSSLLKIRLRKEEIDFRKRNNGLQDPLVARDILKKCSFSATRGQIARLNGARDRCEMENLELQQTRNAEVPEKQKSANGLENARNSQRIDERQRYCEQSATLSRNEQAESINATNEQRYATQSSFNNLTYWPEFQEPRVIGGLTYFARKQPCIPNASGLLCDNYGSVDPNKAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETH9</accession>
    <name>A0A232ETH9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002276">
        <property type="protein sequence ID" value="OXU21652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETH9"/>
    <dbReference type="STRING" id="543379.A0A232ETH9"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="222"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU21652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="444" mass="49687" checksum="09CD89CCEE60650F" modified="2017-10-25" version="1">MEIEKGQNQSGPGGAGGDKKDDKDKKKKYEPPVPTRVGKKKRRTKGPDAALKLPQVTPHTRCRLKLLKLERIKDYLLMEEEFIRNQERLKPQEEKNEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLGDDTDPMVTVMKLEKAPQETYADIGGLDVQIQEIKESVELPMTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVVMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFSIHTSRMTLAPDVNLTELIMAKDDLSGADIKAICTEAGLMALRERRMKVTSEDFKKSKESVLYRKKEGSPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU80</accession>
    <name>A0A232EU80_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002171">
        <property type="protein sequence ID" value="OXU21877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU80"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="19449" checksum="BD697DC9E57C0E72" modified="2017-10-25" version="1">MTTGVRRCIAEQNPSERASGGARHSPGVLQAYQLVRVRRYTSFESGSLGEQGSTSDKESETFGASRVIEIIECLWICFGARRWGVVDVTDRGETVLRKCWDCVLGQTSLYDKTKLTLLSVAARSKKVMVCRDRDLLVSEGLGPALSLYGKAKTFHFLRFYKAALARNNRLMCMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUL5</accession>
    <name>A0A232EUL5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4794 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002110">
        <property type="protein sequence ID" value="OXU22052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUL5"/>
    <dbReference type="STRING" id="543379.A0A232EUL5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172522" description="DUF4794 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27058" checksum="3EAB1B5D4BE9CAD2" modified="2017-10-25" version="1">MRLLLLISCIALSALLVSAKSESSSHPTKLSAVRASSSTSRISRRQDKRNLFQLGYGLQQHQQEPHQVYGPPPAQIPSPSEPEAAHRPPAPVFERPEPISLPVQPHPVSLGSFGPVVFPQHLGKFSLAISDAYLSVLTFLSKVPVAPGPLPPAFPVAHPVPVAPALPPLPIAAPVPVPAPAPIYIPVIQTVTKHVPVPVHVPKPYPVHVDRIVHVNKPYPVHVAVPVHVPKPYPVPVAIRTHYESLHRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUQ4</accession>
    <name>A0A232EUQ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002112">
        <property type="protein sequence ID" value="OXU22047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUQ4"/>
    <dbReference type="STRING" id="543379.A0A232EUQ4"/>
    <dbReference type="OrthoDB" id="7554863at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012534002" evidence="2">
        <location>
            <begin position="18"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="420" mass="46926" checksum="B68786255A40E69D" modified="2017-10-25" version="1">MRIFLLTVTLLVASAAAAPGTKSKRDILKGDSRYGTEYHLKHLHVHGSSGSGDQSQYLPPAQPNNQYLQPVDKQVETQQTFELPSTSYGVPFNSQGAQVAPVSQVHSVSTQYVAPVAAQAPVTSYGTPVVKETEIVQQVQQIEQHQAHAEHHAVPHTSYGVPAQQTQQQVHHQVQQQHHHHVHQPAPVPHNTYGPPVQVHHQIQHVHQPAVHVQHVHQPAPQVHQPAPVPHQSYGPPAQQVYQPAPQVQHVHQPAPQVQHVHQPAPQVHHPAPVYGAPVQQQHYQVHHQVQQVYQPAPQVHQLAPVYVAPAQQQHHQVQQQQHHHQVHHQVQQQQQHHHHHQVQQQASNGGYSYPAPAQRLVFEAPVQSVELSQSHSVEAIPEHHHHQESISIESVRNSAQQSSHGYQQQQTDSNGGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUT4</accession>
    <name>A0A232EUT4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002089">
        <property type="protein sequence ID" value="OXU22111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUT4"/>
    <dbReference type="STRING" id="543379.A0A232EUT4"/>
    <dbReference type="OrthoDB" id="19493at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056499">
        <property type="entry name" value="Beta-prop_HPS5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056446">
        <property type="entry name" value="TPR_HPS5_insects"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF18">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23756">
        <property type="entry name" value="Beta-prop_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23757">
        <property type="entry name" value="TPR_HPS5_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPS5-like beta-propeller" evidence="1">
        <location>
            <begin position="8"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HPS5 TPR" evidence="2">
        <location>
            <begin position="589"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="104676" checksum="B65E44ED2E1A1F5B" modified="2017-10-25" version="1">MQEIPFILTEWQELNSLLYAPLSATKRIQYTCIAVSENYIVLGATSGSIYLFSREPCAFQQLIPLSEGAVFRAQISPDEKTIALATIRGSICLVALKPNVKLMTISTEHIGEKVTCLCWNENSTEVYAGDETGKVSASVISNFMVNGMFQSPSCALMSLDSKIVQMNHTLSLLLISTLNRCYICDTVSEQYKQIGNKPRDGEFGACFLKSHSSDNNFSVERRKKDAISNVKHVFSMTGEVINGLDLEGLPKIYCARPGSRLWEVTATGIVIKTHQFKEALAIHPLPVFKPSIGKLFKLRKQDQTWPAQSINFPQLFVIHHKYLFSYTMNGLYIFDPENAEVLLWNDEFPDIFMAHIIDDKIYLMTSSGVFHCLTLASVDSLILKLHDKKLYKECLEMCQMLRPKLVSSVIEESCDIDIKQATDPSETLVPIISLIKSNHNTQPIKLQSGIVIVNAGHKNSTNEPIVYSEKKLGRTENLDELEDLLISLNTNGTSNSHLSQRNSNGKNLETGNHINKNGFSNDVAEYTKSEDVSSLQKIISDVQADLDSLYTSISTQMKPNITEEELKDIIKLFVETLDNVKKKYEVSSELLSYLFEVIRSAELHYGDCLLENLPIELLKKSENQEMLMQLVKIFVDVNSSNFIECCCGFPYPVFGAGTNKSLEPKFYDIGKVLLDKLQSATESADNISLKVCNQIPFMWRDYLSIKGYTKECISDTLLKQCLQTRDNSVLSTILPMLNEHQWKVTAQCFENIKNGRCVGCGKAYDSDHISSKDFAIDWPGVTRLIIKKQGPSKAMTFLATVNANLPNTSFEKSVYQSIIFSTILNHHGVNHAIEIDQSNVEHNSICSPKILQDVAQAVEQDLDEPVNKEIFGSGPHHWGMRYNLASSTCPCCTLSLQTPVLLGNNGIALFPCGHAYHVNCMIQKKISRCNLHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVC9</accession>
    <name>A0A232EVC9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_001590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002015">
        <property type="protein sequence ID" value="OXU22303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVC9"/>
    <dbReference type="STRING" id="543379.A0A232EVC9"/>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000781">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="498"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="680" mass="76049" checksum="D70FEA73C01519F9" modified="2017-10-25" version="1">MMSDRKAELERKKAKLQAIREEKERRRREKEQKDVEEARIRASTTNKDQQKEVDALLSSFGVAPVSEVLSSLSSVNSLVTPEQSVTATPDTSLQPSSISSAHSAPKKRNRELTIVSVAHTNIPPKEPVVYTKQTQTAQVVHASHDVLTYDDGQAEDEESSLPHLDGFQSKLPPGILPHGLPQVKEVQPAMTQVEKEKEKEKPKEVRELSEEEKQMIILSEEFKRFIDRSSRIVERALGEAVDIYTDYTGTMDGEDGMDDKSHQCLWLNRFFFDERWSRNRCVTAMDWSPQFPELLAAAYNNNDDTPNDPDGVCLVWNTKFKKTTPEFIFHCQSPVMSTTFARFHPNLILGGTYSGQVVLWDNRVQKRTPIQRTPLSAAAHTVSCLLGSRASSSPYSPYSPYRLTVLQHPVYCLKVVGTQNAHNLISISTDGKMCSWSLDMLSQPQETLELQNKQSKQIAVTQLAFPSGDVNNFVVGSEDGAVYSACRHGTRAGVTETYEGHQGPITGLDTHSVPGGIDFSHLFLSSSLDWTIKLWSLKENKPLYSFEHNSDYVYDVAWSPSHPAVFAAVDDSGRLDLWNLNQDTEVPTASVIVDGCPALNRVSWTPSGLHVTVGDDSGKIWVYDVAEHLAHPRMDEWNKFLYCQQDFKNNKADEELDKLNLSSGPSSLSSMASMTSAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVZ2</accession>
    <name>A0A232EVZ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001930">
        <property type="protein sequence ID" value="OXU22522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVZ2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012308280" description="Fibronectin type-III domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23464" checksum="E69C83689CE5DC18" modified="2017-10-25" version="1">MRWSSWPSLCVPVLWLLQVRASLLEDSLRLALCQARCPDDLKCIEECHSAGNNVTDIPYLQKSSESNIHLQCKDANRLVLKHRAGIYVIETLDSFYDNWTSPIISKNRFYESANLMPRHRYRYRIRKVTSQGVSLPEITEWFQTNAETYVPIEVKNLSISEINANKNRPGQLQARLDIIPADGKVPISLLSALVYHKTKFRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW37</accession>
    <name>A0A232EW37_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016652</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001917">
        <property type="protein sequence ID" value="OXU22575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EW37"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000005">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF399">
        <property type="entry name" value="CHITINASE 6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="459"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="14">
        <location>
            <begin position="985"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="14">
        <location>
            <begin position="2576"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="266"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="834"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1209"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1508"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1784"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2490"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="921"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1113"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1302"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1329"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1373"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1521"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1531"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1554"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1801"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1823"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1838"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1865"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1877"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1925"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2498"/>
            <end position="2514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU22575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2644" mass="298688" checksum="92E9EFDC12B1D20F" modified="2017-10-25" version="1">MVVTKKNSCRICLKVFCCADCRDNHENSKHPKPKCSLCVRQALPFGVASEEDSLKKSELLCHLVFNHLPLRCKLCGDRFWKNQDFLEAEPCRWWNERRRKDSKTGLKNDEELAATPDAERKLPLTPQVQPSSEANKSLRSIDTSSIIRLKQENFDSPPELARHTSTPVHHPAVALPGQKLQSGAGGVIPQFSLKTPCSFDKRYSSSATSSSSTFESRYYTGLSQLLSAGKNSNELDRVNQSEVDPTWNSPTYSILKKLEPLNVMKPEGLDSTEKRVRFSDQSVGSAASTSSSEPLPQGACPAASGVTSTDRRASVRASGSTPGRSRRVSRHRGTPQVRTRFAWSDYAADAQWLVVSRFRKQRRQSPAGGGFQPRSQASSRLVQDQGSRAHSSDARPSAGAAVAQRSFPRDSALPAGVAHDRGQHLPAAALPGPPKLLVGSKVLLLILLSTSVKSDEGEKRVVCYYTNWSVYRPGTAKFSPQNINPYLCTHLIYAFGGFTKDNTLKPFDKYQDIDKGGYAKFTGLKTYNKDLKTLLAIGGWNEASSRFSPMVADPHKRRKFVKNVVKFLRQNHFDGLDLDWEYPAFRDGGKPKDRENYASFVQELREEFEKEASKTGRPRLLLTMAVPAGIEYIDKGYDIPKLDEYLDFINLLSYDYHSAYEPAVNHHAPLRPIEEDNEYNYDNELTIDYTINHLIKSGATPGKIVVGIPTYGRSYTLFNEDATDLGSPADGPGAEGDATREKGYLAYYEICKSVQKDDWIVEKPNPKAMGPYAYKENQWVGYDDEDIVREKAKYVNQRKLGGIMFWSIDNDDFRGECHGRPYPLIEAAKEALLEENEKQKPDERPNAISSRKRNRITESTKSDSNTRKSNSNSNRKNTISRSVTTKRPSSKIRSRSNTKTRTQQKNDDESDDENAENSENVETTRAPNRSSRPQVTNRNRFRARQNINNRDNRKKQVSESTTTQRSRNNKITTPEPPTTPDPGSDFKCEDEGFFPHPRDCKKYFWCLDSGPSGLGIVANQFTCPSGLVFNKLADSCDYPRNVVCPKPKSKDAPSTTTQRTTTERDEISEEDDEYEEYEDEEDDVKEVEEKVEEKPKRLTTSTARPLLYKTISRSRPTTTSTTTTTTTTTTSAPFSTAATPRLSDDISEEEQDPRVIKELIDLIKKAGGIEQLEKQLAFQEKGESAQGTGQVTPATISKSLYDRVLNRQSGKNNLFKIPTSRLSTTRKTEEVKDTNEDEEQDEKIENDRSRSKVKFVNGPGRSQFEGLDEVPEVKSLRRYNKPKYVTIERHSSSTTSTKIDDELIEGESDDDEEEDNEEIASSEEKSISNVPEETSLPTQRSTPGYVNIRRTRPTTTTEISRNDNDIKEEDTIDNQPTPNLRQHTFRSTEQTQKATQEYTTPKSRYISINRFRSTTVTPEKEVKQSTIESSTVKPVTTSEILEKELVKDEKTITVAGESGRISISPFTTETPSTARLFSDLLSTVAPTTPYIDEDFDSTHHTTKRVLEANATPNPNIIEDSENQKDTEPVSRSRSAIANRGSSRFRQTTRSLDSNIKKSNDDLEQTKNSERYSRRYRRPLKATTVSNESEDTRVAKITPTQSTRSRNFYRQSRIKLDQQTADTFDNKARTIKNVDLPKTSTTFRSTLGSTVAVESSTEKLSTENLNIFTSEKEDTTEISQTETTPFIIEVTEPITSETFTSTYPVEEETFSSLESSLQTTVPSFLWNSYRTNMDNLNDEEIQTTIFDTTTESFNAKLSTIPSSSTATLSSTDQITKKILLRKRLSTTPTSVDRQPHDDVNSRRRKVVRRLRPLQDPNLNTTRSETTRGRSRYANERLSSEPSYQNSNNENDNQKSTTLSLNQSVKSKSRYIRRKIVKSPSTPTTSSTPTTVINKRKHIFERYRPTSGSLGKLDTLNDENDYNSADYNHDSVPKDTSKDSKSSQINSHLDVPDIPQEKIDISQTPEYRKSRTRFRIKNNEPKEFENFTPKNKVTSRYLSRTTSTTESSIQETLVPTKKFDYFADAIKRANQLQRTTPKFNNDNGVLVSTSKPLVTRLVTSIVESATTERQKISIKKKYSSLTSFTYIPKTTTVSPYSYLQRNKEKRKKQLINEVSPGFSTEQSVEWSTLPIESEFSDKKFTTESSDESSSTIEIESVSDELISHYPDYKEITTHKSISHFITEHPKKISISNNSLYNNKPENDQDYSFVKKSLLISPANQNDSNDTDGFIRIPVKFVGDPDNEYFLLQIPENKINISGISSILKIQVLNSDEFNVKNVNTLNDVNNTNISALDETVISTTSSPPSVNIETKILESKQSQEYEYPSSNFTTNTLIVKKEPTIRIENSTIATIKYADDSFIKNLGINSTVGQVTNSDGKLDIKNIEGAIYNLLNSTVKPKQAFFNPQLIKNNQNSTRKVHRQRVLIYRGAAKDQPLNNSTQKRWIMKKVVRKRIRRTKSKPTEDLETSDTAPEANVLDSFTEVSKPAVTRPNFRRKISTTISPQTTEESQLSTSSRRIISSDRRRQGQKYGSERIVPQTTYLVRSHPYKQITDYDYYEDEEERFVIGKTEGKLLITNRGFIKCLDQGNFPHPNSCKKFITCAKMVNGIVVGTEYTCPDKLSFDPIGGICNWSAGLGCIELSTDTDTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWW2</accession>
    <name>A0A232EWW2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001815">
        <property type="protein sequence ID" value="OXU22840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWW2"/>
    <dbReference type="STRING" id="543379.A0A232EWW2"/>
    <dbReference type="OrthoDB" id="10024839at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037863">
        <property type="entry name" value="RHOGAP6/36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12635:SF7">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12635">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="221"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="830"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="893" mass="96216" checksum="4031D5219A339CC1" modified="2017-10-25" version="1">MQKSKSSSSVVHHGSRLVAKKIWKSRSKSSSRAINLVSAWTPQGKCTWAGTSGRRVTLQDTPLRSLSEIERKVLCRVAVAKLQALNLGVHIRPPSESLSGGSVTAKPKRRAYLLKRKALTTGFFDSKSKEEKDKGWYESSGGLVFGISLGQCLENDRLARIASGEIVDVGCLSRSSRHGSRTSFTSLIETTTTAAKTDEGGSCESLSSKGGALTGSDSGVLELSDGGASSEYDAVPCVVRQCIRHLETTGLHTLGIFRVSPSKKRVRQLREDWDCGREAKIGADQCPHDVAALLKEYFRDLPDPLLCRDLYQAFVHTQKIRNRRLQQEALQHLIQLLPTPNRETLYVLLNFLSEVAANCEDRKTDDGETLAGNKMDTTNLATVFAPNILHCVKPGQARSEVSAERAEERIDVINVVRALLEHVATLFIVPAALLDELYLHMMDSHPAELDLALSRRADEQCPDEADLCSETENYSVEENLSPTATTSPTSPLAASPSATVPSSPSATTSTTFGTLNAGSSASRKLYSREECLHQTAGVGGDIGPRPRRSKRPGSRRKDESTRRGSVDSGSSEDPADPRRKSSPMVITASLTIPMSGAFTLNLDDPDIPYIEADSAQTQVATVPVRRDQQQQPNAPPRRQRQRSVSGSEGGGGGRHGSDSAVGSSATLSGDQPPSSPPSWASTPPASPDSAVTAVSYIPDSQAQQPQLQQQAVLQRVSFTTSSELRQISRSTSQEASRASVAPAYTPSITSIGGAVMRNIAATQPLAVVHRSKTADIERMLRINRAEPSSLTSRQLPSSNVPSSLIDSKKYTKRRYTDSRHQTRHIPDADSLASSSSLASRLSSALHQRSHLSSTTTTSSSSSAAGGSSTGATQPVWKRRELISSAPKERGSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWW4</accession>
    <name>A0A232EWW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001820">
        <property type="protein sequence ID" value="OXU22821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWW4"/>
    <dbReference type="OrthoDB" id="10051322at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="122" mass="13878" checksum="7A7273BFBA13CCD1" modified="2017-10-25" version="1">MPVTNLTSSWETKAALATGASDERKNKSGVGVLSRLRKSQQQQLRMCDIPKPKMRGLLASQIRRHVIIGSLFAFSNSLAYKVFVADKRKQVMRDYYLDYDPDVSLDQMRKHMESTGSWKPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWY9</accession>
    <name>A0A232EWY9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001809">
        <property type="protein sequence ID" value="OXU22864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWY9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="155" mass="17470" checksum="9C40A486A6BDD5B3" modified="2017-10-25" version="1">MRYPPHVLRACIQLHVYIRYDIEIRKRITEHPRVSKPPSIRNAMIYARQGLADRYKIVGHDRPDTVVHVASYITKCNNDFQTVHRLTKLVILQVILLAAVFAVAQSAFIITPSGIIPLAHPNNYGYNPVDGLAGLALPTAQVSQVGPTLRQQHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXZ0</accession>
    <name>A0A232EXZ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001644">
        <property type="protein sequence ID" value="OXU23334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXZ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="9100" checksum="9E554AB09A1F70AC" modified="2017-10-25" version="1">MSIDLSERLHMLSNPRRRRKGNNNFNKFSFGIGITHLKQFDTGIQNKATFFGTKIFGGNNLMIQGRQSRRKYRKFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYY1</accession>
    <name>A0A232EYY1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like G exchanging factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001572">
        <property type="protein sequence ID" value="OXU23555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYY1"/>
    <dbReference type="STRING" id="543379.A0A232EYY1"/>
    <dbReference type="OrthoDB" id="70707at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="233"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="286"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="340"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="398"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48935" checksum="01318BECCE979DD4" modified="2017-10-25" version="1">MFSAIRNLATFVGRRSGKGNSRAPRKPKPKFSKKKKLKAMPIYDYKISKPSDHRVYVWGLQDHGALGTDKKLSHRKGGAAYSGYPHRLSFGEYYHVTDVACGYGFTAFGVKAKDHRILYGTGINSDSQLGYHPKDDKLKSPVVREPRPIFIPLKGKTANILGLSAGRAHLLVLTDEGLYTLGNNGYGQCGRPIINNEDYLKSKVVNYIPDIKGTKIKSVTAGQDHSMLVTENGEVYSFGWGADGQTGLAHYHNEYRPSLVKGDLSGENIIKVACTADCALALSDKGKVFGWGNAEYSQLPAQSDSQQINIATQLKSCDDLGNIIDIASGGSFCMLLNSEGEVYVWGFGILGLGPQVQKVLKPTLVPKTLFGVNPYEPDTKVVKIFCGISQLGAITNAGHLYMWGRNQYGGLGLGNYKDQFFPLRVSIGGIVKKISCGVDHTVSICKPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ54</accession>
    <name>A0A232EZ54_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin-conjugating enzyme E2 C</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
            <ecNumber evidence="12">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">(E3-independent) E2 ubiquitin-conjugating enzyme C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin carrier protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin-protein ligase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_014105</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EC" id="2.3.2.24" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01001539">
        <property type="protein sequence ID" value="OXU23651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ54"/>
    <dbReference type="SMR" id="A0A232EZ54"/>
    <dbReference type="STRING" id="543379.A0A232EZ54"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000039">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="22">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="19">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU23651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="182" mass="20414" checksum="CF836E0D5C6C6F24" modified="2017-10-25" version="1">MAQNINPYYSSQGAQSKSREEKQSMPKDNHAVSKRLQKELMILMMSTEKGVSAFPEGENLFKWVGTIAGPADTVYAGLTYKLTLEFPHSYPYSAPVVRFATPCFHPNVDSGGNICLDILKDKWSALYDVRTILLSIQSLLGEPNNDSPLNPVAAELWNDQTQYKKHLTDEYHKAQAKSEQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZP1</accession>
    <name>A0A232EZP1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001489">
        <property type="protein sequence ID" value="OXU23799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZP1"/>
    <dbReference type="STRING" id="543379.A0A232EZP1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7466" checksum="FE43EB5388D1822E" modified="2017-10-25" version="1">MAAEAAEILPTSPSDKSLTGSLLSESDNSNSNSNSNSNSYSIREDKWPDLVVSRPRKLDAWWTPRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZW8</accession>
    <name>A0A232EZW8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001519">
        <property type="protein sequence ID" value="OXU23708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZW8"/>
    <dbReference type="STRING" id="543379.A0A232EZW8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="263"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="441" mass="48922" checksum="32706CD4F46C1DC8" modified="2017-10-25" version="1">MKLSLIFFVIINVFCIGIESISNGTFVTIKEAPFYVSIIIGNKEFCGGSIISDYWIVSAAHCFLDFENQDVTIRSGSSTDLTFGKKHKIEKVITSEDYNILDFSKTTGTHDISLIKLKKPIIFDEFQQPIKISQDPPKDHDKVIIYGLGIQGPTRTDPFVLKMVEIDIIAQEVCSTNMASLTYVTDDVFCAGNDMTNANACIGDSGGPVVIDGKLAGIVSQGYPCNALFSGAPGFHTRVHKHYDWIIKHTGLNFYRAYGTIVLTIHTGSSTKPTEGNYDADKVIFHEDYIPDSLKGTERNDICLIELSKPIEFNEFQQPIKIAQDPPKGGDRAITYGLGKQGKTRTETLVLKKMESDIMNQEDCRSKYMSYLQSDVFCLGEDGLTIPCSGDSGGPIVVDGKLAGVVSRGELCINRNSNTLSTHVRVHKHYDWIIKHTRIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZZ3</accession>
    <name>A0A232EZZ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001450">
        <property type="protein sequence ID" value="OXU23945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZZ3"/>
    <dbReference type="OrthoDB" id="7697589at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="214" mass="23812" checksum="DE915CBEE93F0171" modified="2017-10-25" version="1">MGIPTMGNRTCSADEFRNSDTLTQLDNNPGMISELISPLASSTTDWKIIQKVELDSYFGTGAILTEQWEKLFHYCDELFSPCIHKSLLDATHKQPDDSINQVNRIIQLLSGLGGSKDVRDKRSVLPFIGQISKILFGTLDENTEASLRDLIQITSNDTKEVARLLAEQTELVEAKLTEMDKKIEVLDVARGFFFKIGIREFTTPESALTAALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0X7</accession>
    <name>A0A232F0X7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicastrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_003148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001330">
        <property type="protein sequence ID" value="OXU24334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0X7"/>
    <dbReference type="STRING" id="543379.A0A232F0X7"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007220">
        <property type="term" value="P:Notch receptor processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041084">
        <property type="entry name" value="Ncstrn_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008710">
        <property type="entry name" value="Nicastrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092:SF0">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18266">
        <property type="entry name" value="Ncstrn_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05450">
        <property type="entry name" value="Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189570" description="Nicastrin" evidence="11">
        <location>
            <begin position="23"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Nicastrin small lobe" evidence="12">
        <location>
            <begin position="38"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU24334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="640" mass="70519" checksum="38F773E4A75A8E63" modified="2017-10-25" version="1">MKHLKCSRISLCLLALVSFVAANRIKNMLYMPIDGAAACFRRHNGTHQFGCSSSKSGSVGVIHIVESMEDVQWLEQNSTAGPYTIVLSFDMFKMDVLKKFKDSHNVNGVLLTRNTSLERPSSYSPEDSCPNRYSGFKSCEEPWNPYGSSLLLEDWPFPMFYMQDEKALEKIKECYLKYNAHNREKQAERSLCAIEMKSFMFAALNAESCMRRSTSSINFNPNVFCDPLGDRNIHWPVGPITDNVKNVIMVIARLDANSLYENLVPGAGSTVTGLVTLLATATYLHSLNATVNNTNVVFSLLNGESMDYIGSSKLVYDLKEGTFRSLGNKILKFEQISHVIELGQVGEGQLYLHANNFQDSSILANVQKALDAEVLENSVPPASIQSFLKANSSLPAVVIANHGKNFVNKYYNSLLDDAVGLAYSRNKSEKLTSSLAKIATTLGNELYRLITNSSIPPSTNTSLVTELVSELLPCYLVSARCPLFQAASPPGTILPDQVLPMYVSVIRSDNAATTLTGQLLAVLTGEQYPHMNSSTCLEKHLLWMAGRNLSGLCINATVNYSNAVSPAFLIEGYNMKSGIYSTWTESVWQNLGMRMLLKPSAAMERLSLILGSTVAGLSFILVWFITSRADTLFNTGSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1U9</accession>
    <name>A0A232F1U9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001304">
        <property type="protein sequence ID" value="OXU24418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1U9"/>
    <dbReference type="STRING" id="543379.A0A232F1U9"/>
    <dbReference type="OrthoDB" id="7696577at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06910">
        <property type="entry name" value="MEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="352"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="482" mass="54426" checksum="9D81971530809192" modified="2017-10-25" version="1">MMTFMGLWPYQDFKTKLFIRTFLAIVLGIALIPQIISIVKYTNEDSDKVIQGTATLLYVTGVTLKILTTITSEKKIEIVYRNIVENWKLLDDENEIRTMTEYSEFGRLLTIGYVAYMFFALGLFVTMPMLPMMIDVISPINGSRPRIFILDGEYIADKYENYGKVYIFESLTCIMSVFVFSTVDSTYAVCVEQCVGLMAVVSFARILDSSYSVNFLLSMGSNVMILSVGSVVILINLGRPMEFIRYSMIFIGLMIHMFYLSWPGQKVIDSSQGILYDAYNNEWYECSKKTKTLLKFMMLRCIEPCQLTAGGLYVMNIANFGSQQSKQMKPTQEPVDNLNTANVNVNVITAHESDSEDEDAGPAGYMPLSQTPAEGEPLEDEDDDDDEDFEWTHAPTEPQQSLPESNEPGEPSVDPETLEVWSAPGNSSNIDLDADKINQVKSAMASFTLPTTAIPDWANSISEDQWKEQLIHRIKEIQKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1W9</accession>
    <name>A0A232F1W9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001191">
        <property type="protein sequence ID" value="OXU24796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7701795at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="654" mass="74036" checksum="247C89C8306651C6" modified="2017-10-25" version="1">MMDHEVKTEVKTEVLSPPSTGSFRSSPDGPTSTKKLDPIDKWRSRVLFCGRTSHGDEEESWSKKIEKQIAVLRVAFPFLTERQIQGKAWQSCGLNSVMGGVPRHGLSPGVKKEFMKHKNPYRCTMHQGSKVKREPIKIERVDKKFAHCPYTFASPTGQLLTPQSIIETLTSQNDLVVNPFSQSQEKNSSPTSGDGLPPSRSAKKRKRRTNKKATNLECNKSVSTTQGQDVIPETPTNSIRSTSPFCSQPLNSQVAAGLDEIIPSLAARSNYFTQAHISECSSTVQSNTEKTQSGLDQDFPKLSQVDYRFIKAQEPEEASVPPTMCTPEYFFVTPKNQIQRDIDGSQIDSDPAVSDLNNVSAERNPTNYFCSNMTPNRNTEILDAKKKITFETIAEVYYSDSYVPENKNKMALMHLINQNLQEGEDIIRAASPTENIENPQMYTPKTLHHTQQETIRSRTFSIDADTNVDHANQMTINPVNNDSLINTNPSRATNASFHLSEKVSELHQSALQRSFQDYANQARSEGYQEFRSFTQELRTPVSLPTTPQNPIKYVKXNPIKYVMPDSVLLSNYSSEYEKAYTKKDLNPSTYRNYYSAKIDESLKNYFDQVIPADQYLQTFFNASDRSFKKVQNEVRRKVRNILLSLEENESGENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2M1</accession>
    <name>A0A232F2M1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSAR_002428</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Alberta</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="NNAY01001234">
        <property type="protein sequence ID" value="OXU24667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2M1"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="25">
        <location>
            <begin position="25"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1154"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1160"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1165"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OXU24667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2074" mass="229193" checksum="A52D17F2AC9D1D45" modified="2017-10-25" version="1">MSYGESWSLPAKQGLYDPTLEKDACGVGFIVAIDGKRSHKIVRDAEKLSARMNHRGACACDNDTGDGAGVLVAIPHQYYADELREQQGIELPEFGRYATGILFLDKSTYKETEAAFEKIAKEANLRVICWRDVPTDNSHIGRVAKKCEPYMRQVFVTGDQEVEALNRQVFVLRKKSSHIIPKPGLRYYICSLSLKTVVYKGQLTADQLWLYFTDLQSPKFETYLALVHTRFSTNTFPSWERAHPLRLLAHNGEINTLRGNVNFMKAREGVMRSSLFGDQLKDLYPVVEPNLSDSGSADCVLEFLVMAGQRSLPEAVMTMVPEAWQNDLTMATEKRDFYHWAACTMEPWDGPALLTFTDGRYVGAILDRNGLRPSRFYVTKDNMMVMASEVGVYDTPPGNVVLKSRLKPGRMLLVDTEEKQIIQDVELKLKIARSRPHSQWLKNQITMDDFRNAHTGGESNGVDADNFTQSLVPKNGLSKADGVSAVNRVWGGDKRIALFGYTLETINLLLLPMIKTKKEALGSMGNDAPLACLSEFQPLLYEYFKQLFAQVTNPPIDPFREKIVMSLLCPIGPESNILEPNEMFVHRLFLEQPILSLHDLEVIKKTSYRGWKAQVIDCTYPKSEGPSGLLKTLDRVCKEANIAARAGFQLIVLSDRQAGPERVPVSILMALGAVHHHLIEERQRMKVGIILETGEAREVHHICVLLGYGADGICPYLVFEMAQNLRADFVLDESMTDDVIYKCYSEAMERGIAKVMAKMGISTLQSYKGAQIFEAVGLADEVIEKCFKGTYSRIGGVDFNILAREGFSRHRITYWDDSFDTVVIHNPGIYHWRAGGEKHINDPRSIASLQEYVNSKNSSAYENYRKTSMEVVQACTLRGQLEFVKDKTAVNISLVEPASEIVKRFATGAMSFGSISLEAHQTLAIAMNRIGGKSNTGEGGENADRYLNQDPQFNRRSAIKQVASGRFGVTSSYLANADDLQIKMAQGAKPGEGGELPGYKVTADIAATRHSVPGVGLISPPPHHDIYSIEDLAELIYDLKCANPEARISVKLVSEVGVGVVASGVAKGKGEHVVISGHDGGTGASSWTGIKSAGLPWELGVAETHQILTLNNLRSRMVVQADGQMRTGFDIVVAALLGADEFGLSTAPLIAMGCTMMRKCHLNTCPVGIATQDPYLRKKFAGSPEHVINFFFALAEEVRSIMASLGITKFQDLIGRTDLLKVRDDIKIFKAKTLDLSMILRSALELRPGVNIKGGSVKQDFQLEQRPENALIEKCRPVLNGEQKSVTVEMTINNETRAFGSTLSYHISKKYGEEGLPENSINIKLKGSAGQSFCAFMTKGVHVTLEGDANDYVGKGLCGGEIVIYPPKESEFNSEANVIVGNVCLYGATSGRAYFRGIAAERFSVRNSGAVVVVEGVGDHGCEYMTGGCALILGLTGRNFAAGMSGGIAYVLDVDGSFKSKCNPEMVELLPLNGKKDIDYVQKLLEEFVEKTGSLIAQELLQIWPEPTNRFFKVFPYEYQRALKQLEEEQAMKETQKEIKAPEPLAITNGNGKTDTVMDIEDVVADAEIAQKKLDKIKGFMKYKRQTGHYRPVEKRVEDWNEIYNFQGVRKGLKVQAARCMECGVPFCQSSHGCPLGNIIPKWNDLVFQDNWKEALNQLLQTNNFPEFTGRVCPAPCEGACVLGISEPAVTIKNIECAIIDHAFEQGWIVAHPPAKRSGKKIAVIGSGPAGLAAAHQLNKAGHLVTVFERNDRVGGLLQYGIPTMKLSKEVVQRRVNLLIEEGITFKTGVNVGKTVTVNELRQEHDAVLICTGATWPRDLPIPGRQLQGIHFAVSFLEHWQKKQMGNKDPLKPELMAKGKDVIIIGGGDTGCDCIATSLRQGARSIVTFEILPEPPKSRADDNPWPQFPRIFKMDYGHEEVVHRFGEDPRRFSTLSKEFLDDGKGNVTGIKTVNVKWTKDEAGQWKMNEVPNSEKVYKCDLVLLAMGFLGPEKYIAEELATKMDGRGNYETPAGKYETSVPGIFAAGDCRRGQSLVVWAITEGRQAAREVDLALMKQTCLPEIGGIVTTVTNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2N3</accession>
    <name>A0A232F2N3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_005275</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001133">
        <property type="protein sequence ID" value="OXU25024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2N3"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56758" checksum="C156EA5023779849" modified="2017-10-25" version="1">MISVILDIIMPLNVSRTKILFEGGEFILDPYQHFYKLYVYFVITSFVIMTSIIAIDTNYTIIIHQILGLLTIVKHRLRRLAIPMNLKKDNSYHAIIKTIHLHNDALQFVDLIESSYSYLFLVFIGFTIIIISISTSIMMAQIGKLLNMIRVAMFVLGASLHFLYINWTGQQMIDHSKELYLNVYSNEWYNLTKEAKTLLKIVMLRCLKPSKFTAGGLYTMNLESFGTIMESALTYVAIMSSFLYMLIAGLGFCQIPMIPIVLDLIMPLNESRPKILFVKGEYIIDPLKHFYKLYLYFAIASLITVTVVSAIDTTYTACVHQILAIFSIIKHRIHTATISFDSKNDISYDIIIKAIHLHTAALQFIDLIDLSYSLSFLILIGFTIVFISIGTVVVIDHMGAMLDLIRLTLFLIGSLMHFLFISWPGQLVIDHSNDLFVSVYANEWYVISARAKTLLKIVMLRCIKPCILTAGGLYVMNLENFGVILKSALSYMAVVASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2R4</accession>
    <name>A0A232F2R4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001104">
        <property type="protein sequence ID" value="OXU25116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2R4"/>
    <dbReference type="STRING" id="543379.A0A232F2R4"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135800" checksum="7CADFC18786A8136" modified="2017-10-25" version="1">MEFGVGGDIAQISAELARLVELMMSPNVSQQQRVEVLNACERFKESSPLCAQCGLFLAQKASNRSSIVRHFGLQLMEHCVKYRWTQMSQTEKVFIKENAMKLLQEGTEPLLQEENHIKDALSRIVVEMIKREWPQQWPQLLGELSQACTRGETQTELVLLVFLRLVEDVAILETLESNQRRKDIYQALVTNMTEIFAFFLRLMEQHFAEFQKQSTLGRTTEAAAHGRVVQVVLLTLSGFVEWVPINHIMADKGRLLQILCILLSHPTFRCPSAECLQQVVNRKGKIEDRKQLMILFTEEALGYMYAAATAAPPTGPSDLQENHYLFLKKLVQVLNGMATQLCSLWSKDDANGVRPVHFGLFLDAVLTFTMHSSLTLVQLANTIWIMFFKHEYIKTDSLVLSYVPKYVEYSGPKIVKVSFPNKRHANGMASYFVDYDTEEEFRMFFHRLRMDLLEGFRNATMVAPLVTFAYVQQWLTVKIRKGSENLAYKSDPLDPEFLEWEALALAFDSVMARILLVSERPNVQTGLQLLELCLGYSPQDPWILSALLSCISALFVFMSMSTGSMAMPGVAILPRVLEKIFAALVFNRPGETKENRSKASKNVRRHAACLMVKIGLKYPLLLLPVFEQIHSTVKNLVREPSQVSMMESLALYEALLLISNHFCDYERQTRLVAEIIGDTSTRFIAIGAQAFKSPVDLVHFLGLDRPVLENSRDERTGSNRSELMYSINTVLSVVKRCAIPEDPDRAARGGFVAALSESGNPIYRNPVTPHIVPVLPPLFDMLRTMNALFTPAALGLLSEGYRNVHGIIESEKANLLGLHTSNNGENSAESELQSAPLARMQSFLTTIHDNCYHMLGSGCHTIGRDLYQLPGLAAALLNSVFSNMELIPDHRLRPIIRVFMKPFIYSCPSAFYETVLVPVLAHVSTHMYQRLSAKWQHMTRLYEAGSLDDDNTDAQEVIDDMLNRNLTRDFVDVLKVALVGGAATDASPQDSMEQDSGGMAVDSPPARGSNSIVAEVVSELGAFILRHPSTCHSVVLCILGALSWNDSNASLRATMLTGPVVRALAADGILTPAMAAHIMVAILQGLQLHGQHEANQGSLITLGAQVYECLRPKFPNIIEVMQQIPGVNPADLQRFDEKMSAVVTTKGNKVEKGKKDLFKKITNQLIGRNIGQLFRKEVKIANLPRLEISSKEVVRVDDLSKNSHDTGLTALFAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F314</accession>
    <name>A0A232F314_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001188">
        <property type="protein sequence ID" value="OXU24817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F314"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11744" checksum="60803F140A05ECFC" modified="2017-10-25" version="1">MATDYNITVAEVKSQLKKSNHSIDRTFQRSITHPKKAFYLLKLKTLHCSPIKLSSILPKESRRQTNCLSRKKNTQSPKETSDPRKCPPRNITKMTITKTENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F370</accession>
    <name>A0A232F370_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_017021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001062">
        <property type="protein sequence ID" value="OXU25286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F370"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759826" description="VM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10825" checksum="F7D6E0FF0B742867" modified="2017-10-25" version="1" fragment="single">MSFALRGVCLALALAVCSAHYLPPCDDELELPYKIELPASRPAYSPVYAVVPAPPPPPPPAYDDCDEIVLVPSKPAAPAYAPPPPPAYAPPPPPPAYAPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4G1</accession>
    <name>A0A232F4G1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_015236</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000996">
        <property type="protein sequence ID" value="OXU25565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4G1"/>
    <dbReference type="STRING" id="543379.A0A232F4G1"/>
    <dbReference type="OrthoDB" id="7551581at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF251">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="123"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="470"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="839" mass="97395" checksum="6DF57AB176537874" modified="2017-10-25" version="1">MEDDDFVNNIIEEAQDLINRFDATSPTLLTPILDAPEGSPASFYTVEHSQTRCQVERTIRILTGTWKIISRSRKLYYTPYKLHSKEGYEFLESLDWLMALYFTWARNEHTNLKLNSKLLLYINIFIISDCYYKIRSIRTVPGSDNDQFNWNFSEAREYLEALRNNADIVQDEGFYYMLDYAGDSGYARSPTLLTPILDAPEGSPASFYTVEHSQTQCQVERTIGILTGTWKIISRFRKLYYAPYKVSRIINVAVILHNFLRVHGFQRRIRIPGVIGLIADCYYKIRSIRIVRGSNNDQFNWNFSEAREYLEALRNNADIVQDEGFSYMLDYAGDSGYARSPTLLTPIFDAPEGSPASFYTVEHSQTRCQVERTIEILTETWKIISRSRKPYYTPYKIADCYYKIRSIRIVPGSNNDQFNWNFSEAREYLEALRNNADIVQDEGFYYMLGNAWMCNIADCYYKIRSIRIVRGSNNDQFNWNFSEAREYLEALRNNADIVQDEGFSYMLDYAGDSGYARSPTLLTPIFDAPEGSPASFYTVEHSQTRCQVERTIEILTETWKIISRSRKPYYTPYKVSRIINVVTVILRNFLSVHGAPDVIPNEYVHRNNIDLRNGEEEIDRILRDATSPTLLTPILDAPEGSPASFYTVEHSQTQCQVERTIGILTGTWKIISRFRKLYYAPYKVSRIINVAVILHNFLRVHGAPDVIPNEYVHRNNIDLRNGEEEIDRILRSDNDQFNWNFSEAREYLEALRNNADIVQDEGFYYMLDYAGDSGYARSPTLLTPILDAPEGSPASFYTVEHSQTRAPDVIPNEYVHRNNIDLRNGEEEIDRILRVYYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F552</accession>
    <name>A0A232F552_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000955">
        <property type="protein sequence ID" value="OXU25742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F552"/>
    <dbReference type="STRING" id="543379.A0A232F552"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12352">
        <property type="entry name" value="RRM1_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12353">
        <property type="entry name" value="RRM2_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12354">
        <property type="entry name" value="RRM3_TIA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000419">
        <property type="entry name" value="CLUMA_CG006354, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000087">
        <property type="entry name" value="Nucleolysin TIAR isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000317">
        <property type="entry name" value="Rox8, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF20">
        <property type="entry name" value="TIA1 CYTOTOXIC GRANULE ASSOCIATED RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="208"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="395" mass="43820" checksum="5A99B23233E25F42" modified="2017-10-25" version="1">MSMSEESNPRTLYVGNLDVSVSEDLLCALFSQIGQVKGCKIIREAGNDPYAFVEFTNHQCAATALAAMNKRVFLNKEMKVNWATSPGNQPKLDTSNHHHIFVGDLSPEIETQTLREAFTPFGEISNCRIVRDPQTLKSKGYAFVSFVKKSDAEAAIAAMNGQWLGSRSIRTNWSTRKPPPPRSDRPRHAANSKPNYEEVYNQSSPTNCTVYCGGFTNGITEDLITKTFSPFGTIQDIRVFKDKGYAFIKFTTKEAATHAIERTHNTEINGSVVKCFWGKENGDPNSVGPNANQQAQQVTSGAGQYAYGYGQQMSYWYPQSYPQMQGQFLQPAQYYGQYYGQQQAQYMNSMRMPTPAGGTWQPGQGGTAQPTPAAPLPPGQQPMVTYTMPPQYPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F557</accession>
    <name>A0A232F557_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000908">
        <property type="protein sequence ID" value="OXU25966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F557"/>
    <dbReference type="STRING" id="543379.A0A232F557"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="219" mass="25856" checksum="E444600C8244DEE3" modified="2017-10-25" version="1">MSILREKVNFKNQSFIADIMYLPIFPEPINGELSSEEFLASSRNVVRILDYFGNIFMPVKYDMQGNIDKLSKKFNQNKKKYSTLQKMLIDEKDKLEDSVVIDAILWLRRALHMIQLFFEYIVYDFNSGKKSEDLMANICKSYELSLEPYHGYMAQQLFNLLSRMIPPRNKVLQVIANGYDVKQEIIIKSMDSFSKRLQENITILKLFYEKHDLESYEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F580</accession>
    <name>A0A232F580_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000982">
        <property type="protein sequence ID" value="OXU25623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F580"/>
    <dbReference type="STRING" id="543379.A0A232F580"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="4">
        <location>
            <begin position="486"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="753" mass="85457" checksum="4F34C23605B3E5A9" modified="2017-10-25" version="1">MLIHLGALFHPLETPEKAVITQSYCFGQEYAEHEAIIASDYDQVALFVARGANLNAKTNTNILKLLLSRKCNVNERNHRGSTPLHFVVKHGTDLKLMTAAGGDVSILNNFGESVLYSAAANKNPEICRYLIRKNKRNVNRHCILGLYPLHIACKAGHEEVATALIEAGAKMNVTCLSDKSPLHYAIYYNRHKIVTILLEHGANINGPKSSDMMLRLAVERKSQVAARILVKFLARLKTKGVAISPADYTLIAEKEELLELLEQCRAELRAMMEHNTTDVTRNVLLGYVRNEDFLRHFEEHVHRFPYYEPTLRSNINWAVNRDRFQWSVSSLMCEVLPVEDPQHLIIQNIFRFLEENDVPNWQKIEEAKSLLNSDSLFERKDRTRLNINNNIRDVVDRGTKVAMRDSWCSNRATFRLGHNNIYVTVFVATFIITHLQLSPILNTQPRYSDPLEGDGLLCRFVSNSPENKDEAGASRSSPPITLGQINYIPQRQYLKFEQANISAIHEKLQEFNSNEDGIQRIEAEKLESLVNLVTAENEKPIDEEMNVFKALLNWPDNVVFPVLDIARLAVLRADVNEQFCSNRILNVLKRHIQNDAVTSNQMLTFRLLANLFSHETGEQFCIRSKNEVLTTVRDLYTLGSKSNEIALSTYILNLVIALNKTNNTFGKMQVLGVIFRLFEILKDTEALFRVFVALGSLILDASSATERKGFVKSVKKCRPVLKALRIVLDGVDSSNVPNKLLSLTRQVLELIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5M2</accession>
    <name>A0A232F5M2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000872">
        <property type="protein sequence ID" value="OXU26126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5M2"/>
    <dbReference type="STRING" id="543379.A0A232F5M2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="717" mass="81874" checksum="D7A47B3CCB7F48AA" modified="2017-10-25" version="1">MSSVFFNIYEDDDDEDSCSDTVTVIGDLPVDSYTENRQLLNQAIEEENLLQISYHLAFEPDPHVPILGKPSPLWMAIHNSTPEIVDVLIRSGYSIMEMQCPSTYYFHSDDYTYTGDLDSLSDYKGYTYFTYMTLLHWAVINDSYSKVKVLLAHGASPNWVDERGNSVLLYAVESGSVRIAEELIKQGAKVNEPLTKHPGNYLIHDAVHSGNFAMVKMLLNYGAKVNVINCDDQSVLHLLLKPKQKEMPDLVQLLADAGCPINYRQQDKFSPLYLAVEQRRTRTCRILLEHLADPNAGIYGTNAFPLVMACEYRCLSLIRHLLESGAYVDQRLDSRQTLLHVACTKGHAEVVRELLKYGADIDAIDNSHKTPLHAAVERGSKWIVRLLLRNGANAEVPDNEMYTPLHRATFLGLVDVVKILLEAEANMNTEDYWCFTPLHTACRKDKLQVVKILVKMGADVNRKSKIKVTPLHLAVEHSSTCLVQFLLRKGADVNCRGPDNKTPIFRACSYHNVAKIKLLLNYGAKINVKDNSGSTPFHQLYYKEREAGQIMLKHMALRFYNGERIEACDLRLLRDHNAAHAYFMNALSRVMMLKNDKFFRNVTFFDVFCMKPSQLLKLVRNNEFIGAFRANYGKHKSFWDDLEIKFEKALMERELLYSAEHFLASIFGEYLPAAALERMATFFIIDALDQMEEEEARKADNSFVHPLIARYQRRGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5Z4</accession>
    <name>A0A232F5Z4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_012182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000841">
        <property type="protein sequence ID" value="OXU26241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F5Z4"/>
    <dbReference type="OrthoDB" id="2152335at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000147">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="536"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="635"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="736"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="843"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="946"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1396"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2511"/>
            <end position="2531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="5496"/>
            <end position="5543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="5582"/>
            <end position="5603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="5662"/>
            <end position="5684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="5751"/>
            <end position="5936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="6270"/>
            <end position="6302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="6543"/>
            <end position="6727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="6788"/>
            <end position="6870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="6886"/>
            <end position="7064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="7262"/>
            <end position="7489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="7537"/>
            <end position="7568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="7616"/>
            <end position="7650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="7702"/>
            <end position="7731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="5504"/>
            <end position="5519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="5529"/>
            <end position="5542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="5586"/>
            <end position="5601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="5668"/>
            <end position="5683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="5751"/>
            <end position="5775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="5791"/>
            <end position="5883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="5904"/>
            <end position="5936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="6543"/>
            <end position="6566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="6582"/>
            <end position="6674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="6695"/>
            <end position="6727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="6788"/>
            <end position="6812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="6828"/>
            <end position="6870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="6886"/>
            <end position="6920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="6946"/>
            <end position="6998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7036"/>
            <end position="7055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7262"/>
            <end position="7285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7292"/>
            <end position="7344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7352"/>
            <end position="7393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7404"/>
            <end position="7433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7441"/>
            <end position="7450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7451"/>
            <end position="7462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7463"/>
            <end position="7473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7537"/>
            <end position="7547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7635"/>
            <end position="7650"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="7755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="7755" mass="878431" checksum="5A42D31CB799E40F" modified="2017-10-25" version="1" fragment="single">[encoded data, 7755 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F743</accession>
    <name>A0A232F743_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000752">
        <property type="protein sequence ID" value="OXU26674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F743"/>
    <dbReference type="STRING" id="543379.A0A232F743"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="78"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU26674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="273" mass="30606" checksum="B1AA453A5416ACAC" modified="2017-10-25" version="1">MRTVCYKCRKSLISAVKSHKGEHLHLRGILRQEMGSYLCIASNGVPPSVSKRYYNRAKPACRCSLNDKLAMRRSAVKPSIRTKEQVVFARVNGDVTLKCLVEASPKSLTSWYAETGNADRNANAFFSSDWKSKSLKIGLSERHEVTESAINDYTYQVNLTIRRVRPSDWTAYTCFTENSFGTASASVRLREQHKSASGRRVAHRKSKDQFEDAPEHVDGEYLPALPGAHYGSTDFPGSGSPDRDGGARRTPASTGRQIILNQHSQQRYRAYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F795</accession>
    <name>A0A232F795_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000743">
        <property type="protein sequence ID" value="OXU26726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F795"/>
    <dbReference type="OrthoDB" id="8191828at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850590" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8993" checksum="04B63C03FFB218DE" modified="2017-10-25" version="1">MAKLALCLAAIVFVILAQDVMPSESTFAQPRAPNFQYFERPQYRYPYYDENGKGRLLYGYGGPQLYQYKTYSALEGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Q4</accession>
    <name>A0A232F7Q4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000707">
        <property type="protein sequence ID" value="OXU26871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Q4"/>
    <dbReference type="STRING" id="543379.A0A232F7Q4"/>
    <dbReference type="OrthoDB" id="10068328at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="2">
        <location>
            <begin position="393"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="584" mass="66994" checksum="071A29F3FD514481" modified="2017-10-25" version="1">MDENTATEELQRSMSELDISEDNDSPSGERWDPVGANNGDDDDFALEYKHQHGMESHCSEMEKLRMLEEEQEMLNSSLIALTTHFAQVQFRLKQICDAPTDKKEELLKELEEFAFRGIPDIQSNLIFNTRSSSPSSPSHRHDSIQFEDKEADLKMEMQRNKQKELICQLKSQLEDLEKYAYETGAADLPQSIVLERQNLIINHLKEKLNFNVEDFSKLSADDLRWQVDFAINQIVSPLKMKEQLITQLKTQITDLERFINYLQGEVSTETLACTCACPVHTNGPTQNYNAKKSFQKASMSENTTSLSTVRKVVALLHMYIMSQMGCGSQRSHRVKKKDTLYGWRDLRTRLDIAVEHVLETIAESEYCSSRGNMLEDISYNSDSDSAANQYDAKVTLAVRKHLAICIRDLMQHGTTTDATVNSVVPFVGCFAQRTYSPSNFMHAWEIILKYYEIKNGHRYNSSPAQKLSQSFNLDLNGGQMASSKQNLLITIGNIITMHTPYKRSFDSNFKAFICAALNANKLVTWLKLILQCQYLLENYYMPWSYVIKTGFQDAFHTLDKLTKHKFDLPIDLAIQQFQNIKEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F872</accession>
    <name>A0A232F872_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000754">
        <property type="protein sequence ID" value="OXU26659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F872"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="48" mass="5564" checksum="D8FECA6F0FDEB5FE" modified="2017-10-25" version="1">MGSTTIGYLIRKYAAVVIFPTIVFSSIYADLRRTQKWKARLAEQNKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8Q7</accession>
    <name>A0A232F8Q7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000684">
        <property type="protein sequence ID" value="OXU26992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8Q7"/>
    <dbReference type="STRING" id="543379.A0A232F8Q7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="411" mass="46321" checksum="0083D349999FF455" modified="2017-10-25" version="1">MQFVLRALAINNNPTIHSLILVHILRDLGLPWQICKFFYNLTCSRSVYFNVGGVIQGPFETLKGVPQGCCTSPVAYNIYTHKLPNHIDPDCQYLCFADDVALFVSSPDLNFCTTVLQNSLITIASYFDSLGLSIAPEKTQLITFSRKQTDTSEVTLTFGDTIIHSIPQVKLLGVTFDSKLSWTPHYQSLIQKGTRYTNLIRSLCGTWWGGNPQSLIQTLREKLGVTQRRALRSCLGLRRSTPNRIVYAESCELPVSLRPKKLAMQFVLRALAINNNPTIHSLESLLTLLRNRNILNLLELLILRAYARLKKHRSKIHSSDVLPCYTYSLESQSLLSKIIISKGQKIKSSPNPPRKFSLLFRDLLTSSIAFYANGSKSSEGSYVGIGIYCPDLDLNLRYRIFSYALLPRPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F964</accession>
    <name>A0A232F964_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock 70 kDa protein cognate 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_013939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000613">
        <property type="protein sequence ID" value="OXU27394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F964"/>
    <dbReference type="STRING" id="543379.A0A232F964"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000134">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000003">
        <property type="entry name" value="heat shock cognate 71 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="589" mass="64307" checksum="F1ED86F2EF2313EF" modified="2017-10-25" version="1" fragment="single">YSDAKRLIGRRFEDATVQADMKHWPFNVISDGGKPKIQVQYKGETKTFFPEEVSSMVLVKMKETAEAYLGMTVTNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFVQEFKRKYKKDLTANKRALRRLRTSCERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMDKAQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEEVQDLLLLDVTPLSLGIETAGGVMTALIKRNTTIPTKQTQTFTTYADNQPGVLIQVYEGERAMTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVNEAEKYRSEDEKQKETISAKNGLESYCFNMKSAVEDEKIKDKISSSDKQVVLDKCNEIIKWLDANQLADKEEYEHKQKELESICNPIVTKMYQGAGGGMPGGMPGGFPGAGGAPGAGGAAPGGAGGAAGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9L8</accession>
    <name>A0A232F9L8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_016056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000632">
        <property type="protein sequence ID" value="OXU27302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9L8"/>
    <dbReference type="STRING" id="543379.A0A232F9L8"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06755">
        <property type="entry name" value="PDZ_RapGEF2_RapGEF6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01785">
        <property type="entry name" value="RA_PDZ-GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000001">
        <property type="entry name" value="Rap guanine nucleotide exchange factor (GEF) 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF249">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="7">
        <location>
            <begin position="141"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="259"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="492"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="603"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="897"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="906"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116062" checksum="2796FD285916DF97" modified="2017-10-25" version="1">MYQEAYLGSRSAAPRLPRAVQALRSESVDRAHPARVQPPPPPAFPRRRFSVCFGKRTGGSARRPNECFVLEPSEMIAVSIVHNFLSSQRSKSRHVPLFARSVSIESLVYTEEEENTRRHEEDGRVILVTELRGALDGGARRGHVVIRGTSDRLMLQLIEENSITDPTYVEDFLLTHRTFVDNSQFVANQLLEWFEQAQVRDRVARVVLLWVNNHFTDFETDPMMMEFLEKFEACLEKEKMLGQQRLLNIACAAKARTRNVVLARPSRDEVLHFSILGGYEKKYVEKKSKAEDVGLKRGDQILEVNGQSFEHVNHAKALEILRGSTHLSITVKSNLLAFKEMLAKPDNSPRQRSRPSKPEILPRLQTDPRIRLSTHVDPLTPVNPLNPMVGGVPLLIPADSSNVSPCKDAKKEHKGFMTLGPRKRFQKALMKMNILPKNMINDGVHADDPLGPPHTPPGTGLSQQSSNLYHSRSNPDLTSLYCYDEPRAPDYPEHVLKVYKADQTCKYLLVHKETTAHEVVMLALQEFGITESSSNFSLAEVSVGEGGMIKQRRLPDQLQNLAERIGLSSRYYLKTNGISETLVADEQAPDLVRESQVHFLQLNAIEVAAQLTFQDFNIFRQIESTEYVDDLFELKSKYGVPMLSQFAELVNREMFWVVTEVCSEHNIVRRSKIIKQFIKIARQCKECKNFNSMFAIVSGLGHGAVSRLRASWEKLPSKYQRLFSDLQELMDPSRNMSKYRQLVASEQTQPPIIPFYPVVKKDLTFIHLGNDSRVEGLVNFEKLRMIAKEVRTLTNMCSSAYDLQTMLERGGQPSSSAMVALNQMTTGGQTATVKRRKKSAAAPNPKKMFEEAQMVRRVKAYLANIKVISDEEKLHQLSVECEPHVGAVAMAAAVPLGGSRGRRHPSPTLSTTSSASSTSEGRKSIQGTKFGAASPQAVRKMLALSDPHKTRPYQPKHCAAPLPVPGLALHSSALEQSPGAPRRVGSGSNRVPMHERSHSDTPSGLPPPVDLSAESSSVTSLSNLQPLRKTLTSVDDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA86</accession>
    <name>A0A232FA86_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000579">
        <property type="protein sequence ID" value="OXU27575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA86"/>
    <dbReference type="STRING" id="543379.A0A232FA86"/>
    <dbReference type="OrthoDB" id="10052721at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.710">
        <property type="entry name" value="SATB, ubiquitin-like oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038224">
        <property type="entry name" value="SATB_ULD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032392">
        <property type="entry name" value="ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16534">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51982">
        <property type="entry name" value="CMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CMP" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="12893" checksum="43EE41D12143FE48" modified="2017-10-25" version="1">MPFQDLVGEALMRLSYSNDLILSARGSIVIRNWKPLPTEKVAEGPLLTVGDILAELINVATLKIQVYRSRPPPPTPAAEVRDKLLRLLLLRSHAVLVAAGCPLDEVCIRYQFLIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAD0</accession>
    <name>A0A232FAD0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_000345</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000635">
        <property type="protein sequence ID" value="OXU27277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAD0"/>
    <dbReference type="STRING" id="543379.A0A232FAD0"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11876">
        <property type="entry name" value="SH3_MLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14061">
        <property type="entry name" value="STKc_MLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000076">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000085">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF293">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="223"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="61"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="569"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="687"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="926"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="515"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="943"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="957"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU27277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113032" checksum="50E2D59D63FE2580" modified="2017-10-25" version="1">MRLDTEQDSGAPGVLAVPGFNTCVSHMPPAGLSARGLPTLMDPGQPDARLRSERLLLYSENGSTQSNSSNAGNFSPRYQHTSRTNNQSTGGQNYCYTRTPSNMSDSSVSDTHSGGTARTLSQQTSPSHGTLSSQSRHDSSTLFTALYDYVAQGEDELSLQRGETVEVLSKDSKISGDEGWWTGKIRGKVGIFPANFVAEAETIDRVSSVIEQVQPVEIDFEELTLEEVIGVGGFGKVYRGFWNKKEVAVKAARQDPDEEPSATLQNVRQEAKLFWLLKHENIVQLEGVCLKMPNMCLVMEYARGGSLNRVLSGRKIRPDVLVDWAIQIARGMDYLHNKAPISLIHRDLKSSNVLLSEPIENDDFQYKTLKITDFGLAREVYKTTRMSAAGTYAWMAPEVIKKSTFSKASDVWSYGVLLWELLTGETPYKGIDALAVAYGVAVNKLTLPIPSTCPQPWRCLMEACWLSDSHQRPGFAEILVALDEVRSAFAATPHESFHTMQEDWRLEIEQVLHGLRMKEKELRCREEELSKAQVQQRQVEESLRQREKELAAREIDLLERELAVMITQQQSNTPTPNARRGKFKKSKLRSNKLGNKISAPSDFRHTITVQNTAPDRVKSRNPSRSNSPPNSPSIPRLRAIAFSDYITDEGRVNYNFSGMHCTPLLQEIGNVRKSDARKLYSSANDLVDAPATAPGSVDRHVDDYCSRDDEEDDSSSSSFVVGCVRKTKRRERSKSKDSSYVVSNSSASGKRRDSSESRLTSLADFFRSPSGSRKSSLNNERKNSANVTIKINDSDGLESSPENSVAHKSRLSKSPLRVFSRVKAWGSRDALDDKSGGSAGSVKVEYSVLQDSVSLPRFDKQQTTTSSTPSFLAANSREGIDFENLESELCNLESEQSNDDSSSTSLRSRINLKLLQELDFHNKASEGCNNSSNFSDNEPGFGSDDDTEDLIEDNDSSARNGTNGTRITRSVDDTRIIGSKPTTDGTNNHNLTTICSFAKPKIHVAKKFFRKNCSGTAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAQ6</accession>
    <name>A0A232FAQ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000554">
        <property type="protein sequence ID" value="OXU27702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAQ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10441" checksum="1596C861CF97FDCC" modified="2017-10-25" version="1">MTTVSEKNDADKDANQEHENGNADNQNADADVIQTTINEEDLIDGLDVVDAWDDEDEPRRRSWDRTRGKERRTSRYQRLWLLCINSLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAS1</accession>
    <name>A0A232FAS1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01000585">
        <property type="protein sequence ID" value="OXU27538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAS1"/>
    <dbReference type="STRING" id="543379.A0A232FAS1"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF63">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="370" mass="43257" checksum="D2BA5BD0F7377B28" modified="2017-10-25" version="1" fragment="single">SVTSMRFISIAVNRITMSRTLRRNVPKFLVLFTVGALFFLLLVRSKLVRSYDEPEYKNQDTERAKREAEIENRERIARVRRVCKKYQMGPFKSASSDVEFKEPPAPQYSVFYIDSKHNISYCPIYKSGSTTWIYNLCLLNGVSEEELSSGKEQISVIARRIMPELDYPEADVLLRKTAKLLIVRHPFERLLSAYRDKLENSVAGREHGSLHFYKRYGESIVRKYRDKKRPTPSSNQVILRAGLAAPAGIEPTWREFVDYLINTDLASYADDHWTPYYLYCTPCLINYDIIAKVETLWRDQAYAIHQLGLDQQIRPRWRHSTSNNVTDAATVYFSQLTKEHVRKLHEKFRLDLEMFGYDAERYYELATAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBZ3</accession>
    <name>A0A232FBZ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000529">
        <property type="protein sequence ID" value="OXU27857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBZ3"/>
    <dbReference type="STRING" id="543379.A0A232FBZ3"/>
    <dbReference type="OrthoDB" id="10033972at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="396" mass="46355" checksum="8A9F32FF763D3B7A" modified="2017-10-25" version="1">MGGEAIVSGHLSRPETYSPVRRRGAAAHVKIESPKESNPSDMDRKDQRVCIKFCVKNEKTEAEIYDMLQKAYGKASLSRYIVYEWVRCFRKDKDLMKDDLWAGKHSASCNDANVDKVRQKIHEDRRLSIKEIADELQLTQESIQSILTVNLGMKRIAAKLVPRFLNDDQKNRRFEVCLELKRRAENNPLFIDSIITGDEMWLYGYDPEAKGPHQYAWKTLNEPWTRKLRQARSNVKTLMIVFFDSQGIIHQEFVPQNQTVTQAYYKEVLIRLREKIRNKRAQLFRNRSWFLHHDNSQGHNGLVIREFLAAKKIPVLPHPSYSPDLSPCDFFLFPRIKFFLKGKTFDDVGTMKKGTIAHLQTLTLQDFQGCFQKLQERWAKCIDMRGEYFDSDKNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCB8</accession>
    <name>A0A232FCB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000428">
        <property type="protein sequence ID" value="OXU28466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FCB8"/>
    <dbReference type="OrthoDB" id="1063785at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF372">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP76A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393983" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="1862"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="749"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1289"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1797"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2228"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="808"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1291"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1309"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1797"/>
            <end position="1808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU28466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2334" mass="256859" checksum="36C34A29FDC5765C" modified="2017-10-25" version="1">MTPKRRLRPLLLATTALLIWGNPNSTRASSIPPTVLPSPDKPIPSVMIDEAGSRRISSSASSSSANGPQHVRGRDPPGSPVNLFTPDEFQFYTLNGHGQLVMKQMTKQEIQSMIAAGGGGPTVGNLPVDLGHHQSSMTADAVPKVSDVVQNVQKVLKSELNKPVKVHTSGSSIPGSVNSQWTNMLPYILSGGSVDQQDVAQDTSIILPALDDDESYVDVVPLQGNKPMVNQYEPEVNYVQVQSTSNDQMVKPVSAKPTKGTSDKPINLLGNMALDSGIIGEQDPFTVPTKGKPSRPSSTPTYHKYTTTRPSVISVVKDVPKVSEKNSTGSKPTLYIPLSVSSSLLTDSEKQEEYSIPSYGFKPDISAESTSIAAPTKKTTTSYVYPDEASFTRVPMIQVPVISADKISTSTQRTNQQQTPMFEKLPTISPASITSTTVKETSYPSMMNLGPIGGFKKPETSYKPPTYQYPVYDPETKSSPTASTTTRHPVYEPATKPFKTPTSTTYHPVYRPATSPSTRRPVYEPSTRPTTLNFKPSFSRRPIFEATTAKASPALLEITTKPSSQTEGTRYPSGIYTTGKASTSAIEFATKPTIQAEEVKVTRYPDTTYQTQTTGKSSTPATESATKASQSSSTTQETTTRDEVKDLSPVYVVQQLLESDKYPAIPSASQSLDNSEAVKDSYGILEKLPTLNASDIDKNEGSTESYNTYDYDKHTVIYSDTSDKLPVKTTVFSEMDKDSEDMSYTVAPVKAETESDTPTTNYYATEKSTQPQPIDTVTSDQKKPLKTEESTVYEASSTVPLKSEEPSTEASVLKNKTVQTENTPIAETVTPKYEINSTRPASAEETKRPLGSEVNKDAPYVKVSQNEKTEESPTTVYVNEPEQTQSWSESEMTTQFVSIDEGVTEIQMIEHVSEKEMDKKPVTIEAVTKKQESTIKPIQDSTTLKTEYSELTTDYVAPINPIADSVKKEESSASSTTMENVNEPIQSVKKTTTIPLDATKEIIEKVTMTVEDKKPTTELVTDGITILDSEKEKPAEKEAAITLEADKITKPAYPDQTKLMTEAIITTSTEMNQADKNPPTEFPVYEKMETITESALDKQTEKINVDIDKQKIQPMEEEVSTVKVIPIYDDDTSIYTLISENPDRIKFADQAPTTIVPVAEKQEETKLIALPAKTTQYTKAPTITPSTPVQTTQSEPAQDTVLPGLEETFNNYIKEHYDPNLSSTGEDDEISHMTTFPPEIVKSSLSYNDGVPTWPTTISNYITTNKPNQYTGTELPNMQSSSFINAMETTENSKPDKREEPVATPFKDSPTTESLSDKNTPFTTKSPVTQDKSKVETPIIYLDLANSDANKQSVPPQPNKDFMSNSSLTRIKIKNPVMDIDKIISEAQAQTNTPSTVPYTLPSENRPANNFASGIIAGYPTYEQMKPVTEQILGTTLYEIVGGTKKPTLNVKPVQDKLVDSEQSESNISYQGKLTTALPVDDVKITEKLDFPSTMSSASDVGTTIYQASETPNYESYTQIPFESLPIASKPSAPSQPGEIYDPPLEKINDLINQLKNTPSEHASIGYDFSNGVETTIVPLDRFETLITESNPAPTDDTLTTIIEDLSKTSTESQNSTYVVIQTLPYSKPVLSSTEPTVRQTTIKEPTTAATTTTTAQNISKTKPSTSATTVLSIVKQPTTGKPYVTSTYSPTKGSIDKIQSTIDKSAGRINLEEEKNKMQQPIKPTEPTKFTIKNKYHYSTIRRGTSPGYQNYSRKTTKAPIKETAATAIPDRTTSKPIEDTKETSDKWTLIPQKGVEKVDEKPEVKKIPPASSKDGAQPINSQIVTLDHASGAIGLDQSNKALDEDVAEFLNMCNELSFKFWTLANSNLSSARSVTMSPFGMISTLAMIFLGARGLTSNQMNDILKLDDVVTFNPHLVFQNITDTVTLARGQGIENAAFVRALFADRLKVRRIIPFYKEQTQQFYEGAVVDINFSTAGDILRRRTNLLIRKQTGGRIKDFMKQHTVPLRSPLTALSANVFQTSCDGPDASSEGRDGEMYFAVSQTVKQRKLVPIPAVVWKSGVSAGYEPSLDATAVALGESKRPVSLIMVMPGQQGLTAPGDNLERLENRLFGNPSDNALEKLLKVIIPRRVELQMPKFSQRSIINVTSALKKMGFDQLFTRTADLKGINGAGHDLYLADMLQMNLFCTCGDENKPGGKHLSETYPGTPSRHNRAWEVLSNVDDNGVNDFAETRSSDNSEATEGCEEDETESWSGSNDSSNEEHDRMKGLRQKMHQKRLRWLTSPRRTRCRTRRQAEPEKPRMKMDKPFLYLIRHNLSGLILHIGRFNPKNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCZ3</accession>
    <name>A0A232FCZ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA topoisomerase I</fullName>
            <ecNumber evidence="9">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_011728</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01000461">
        <property type="protein sequence ID" value="OXU28217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCZ3"/>
    <dbReference type="STRING" id="543379.A0A232FCZ3"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46596">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, dispensable insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="12">
        <location>
            <begin position="698"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="1059"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU28217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1101" mass="129044" checksum="90DDBA7B057D28A0" modified="2017-10-25" version="1" fragment="single">WWSGARASIYTAQHSRTLRARQPRAALSDIERASQPVLIRSRQRLSPAIVEKMELEQPVPRADVDLEKKAKENSSAAGNHGDAQMNGMTNGYDHKKEHKSEHRDKDKERSHKSEHKDKERSKDKEKSHKSEHRDKDRHKHSSSSSKDKDKDKHSSSKDKEKDKDRSRDKDKKSSSSSSKDKEHKSSSSSSRDKEKDKERSKDKEHHKTSSSSSSKDKHHSSSSKDKDKEKDKERSKDKDKHKDRHSSSQSSSRDKDKEKSSKDKKHSSEKDKDRHSSSHSSEKDKQRSSDKEKHSSSEKDKDRHRHDKDRDRHRHDKEKSKHRDEKERKEKNREESKSKDENKVKEDVNFEPEIKTEIKMEQESFKEHEEDYDSGDDSQKLYIKEEDEEMKQDNSMDSTDANDTKLSDMHNTTVKTEEDESDEDMPLASRSSGISPGVKRKVETSDEDDDIPLSARKKLKKEPVAKKQKKKKKVESEDEEYDEPEEKPQKKRKPKAEKSENSSPKKKKKEDEEPENHFCAEFFVVRLKRNFPTLKSTKTLEKRWEEEKKNDGTKWHFLEHKGPVFAPEYEPLPPSVKFYYNGKEMKLTQDTEEVATFYARMLEHDYTTKQVFNDNFFHDWREVMTESERAKITDLKKCNFTEMHKYFIMKSEERKAMSKEEKKAIKEKNDEIQKEYGICTIDGHKEKIGNFKIEPPGLFRGRGEHPKMGKLKKRLVPEDVLINCSKDSVHPKPPPGHKWKEIRHDPTVTWLASWTENIQGQVKYVMLNPSSKLKGEKDWQKYETARKLAKSVDKIRATYREDWKSKEMRIRQRAVALYFIDKLALRAGNEKDEDQADTVGCCSLRVEHIALHEKKDGKEYVVVFDFLGKDSIRYYNEVPVEKRVFKSLQLFMENKSPGDELFDRLNTTVMNKHLNELMDGLTAKVFRTYNASWTLQQQLEELTDPNSTVAEKILSYNRANRAVAILCNHQRSVPKSHEKSMENLKAKIDAKREAIAETEQIVKDAKRDAKHGSVKEKVLYEKKKKQLDRLKEQLMKLEVQATDREENKEIALGTSKLNYLDPRISVAWCKKHDVPIEKIYNKTQRDKFRWAIDMAGPDYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD04</accession>
    <name>A0A232FD04_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000398">
        <property type="protein sequence ID" value="OXU28666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD04"/>
    <dbReference type="STRING" id="543379.A0A232FD04"/>
    <dbReference type="OrthoDB" id="10658564at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1111" mass="128215" checksum="311CC2493F732D05" modified="2017-10-25" version="1" fragment="single">SSLSSVAIKKLPVPRNHEESTMENRNFALCCYSRIRLRIESVQLSGCNQLFGLCRIGKHDNVSDINNHEQETYIEYVEGNDKNGTPEMYLVQNRDKKSQSRRCSGMDNLLIDRKVYISNNTFVLILNVENPRHLTQIISDRSEIVNIAVHPYEGDLYFIDLKKHIHNNSITNAIYRANLDGWNIIQITEPVDTRMSALIIDFYTDRLYWRLFEKEDIYHSKLDGSDFKRVHVPGTKFNVSEHHRGAKLHDIPSYSLHSISFDKDYLYCPKKRLQYNVSEKLITKLIQINLIIVQELVVYDPEVQKMKCTSTAKLLLEVADKPNLFVIVANVPGLCHINSTSASSVNTFGHQIIPCNDDHPSDSYKLSQANRPRLLLSPHNFLKMETFRGINYDASKKSIYYASNAIGDREAVKIVKRNFSSSVVEIIFDNTLFVSVDKDSRRKFEVTGLSFDWITGNVYMNTRTSILVINELKSKHSITIIDNRSEIISPVVHPNEGYLYFIDAQLHSGERRNSVRNAIYRSNQDGSNIEQITPIYDKEISTLAIDFYADRLYWSEPSSEVIKHSKLDGSDVKSFRTGLLYVGLYNGVLGSIAVDKDYIYYISKSPNTVQRHKKINVEKDETFKLKANQETPIVELMVYDPDAQQVREDHPCLSNNGDCQKFCFVRSQNDGKLKRSCKCSDGDVLADDEVSCHSKSLKQLSVYNRVSLDEKDVPDKPDIILLTEGNNEVTPAICQIKSFELISTHNYFQQHKTYYQIPLHTRTFTCRQPWCISNRGGGRDRYGSNRLIQKQLSRFRSLCYDARKQLILYFSSGDGFGIIKHHLRVLEKTPVRFANTDIDFRLKDFTYDWITKNVYINGHKRINVANLENPELSKEIISNRKENTNLRVHPNKGYLFFMDVNRRSNKNEKSRSKHAIYRANLDGSNVTRISKFVNETMYGLSIDYYSDRLYWSIPSLKIILHSKLDGTDVKNFSCESYGTIVFDKNYIYYVDGETDSIVRRKKLENEDKDFRINSVQDNRINDFIIYDTESQQIRKDHPCLLNNGDCQQFCFAVSEFDKLKRVCACKTQDELGVDLVSCTPVKNDTSNKCNNSTKPKLLHFFVLVNPSLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD57</accession>
    <name>A0A232FD57_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000437">
        <property type="protein sequence ID" value="OXU28398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD57"/>
    <dbReference type="OrthoDB" id="8186325at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032134">
        <property type="entry name" value="DUF4816"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF4">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16086">
        <property type="entry name" value="DUF4816"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="389" mass="45656" checksum="280096CCAD61ED60" modified="2017-10-25" version="1">MCYMTDPPQRYTHKLIIQRLTRRAPLSSYGPPAASYGVPNTGVSNSYGPPPAPSSSYGVPSNSYGAPALGFSDASASAHSFGGSSSSSSFASAGAVGHVSDSYGAPAPQYGAPAPVYGAPQQQQQHQPSGHWEKKLTWKQEWQKVWKTENKMTWKQEWKKVQVPVWKEVQVPIWKDVQVPVWKKVQKPVWKEIQVPAWKEVQVPAWKKVWKPTWKEVQVPIWKEVQVPDWKKVWVPEWVKVGIPGEKHLGTDGHGWQYTSHDLWKKKLVWKPSWKKVWRTEKKQTWSTDKKLEWVAKWEQVWKTEKKQVWNTEKKLVWKEESVQAWDNQKKQVWVTEKKQVWKDEWKSRWVPAWKQVQVPDWKQVWKPVWENVWVQDQHQQNHDEGYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD78</accession>
    <name>A0A232FD78_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000405">
        <property type="protein sequence ID" value="OXU28625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD78"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="9808" checksum="F38F62473E6B92E8" modified="2017-10-25" version="1">MARSERTRRKQHRRRQLRNTATVEPPVVVEDEPLGLWRHVGWADAFVLLIASPLMINICTGAFVLGLCYFLGPTIRQDEPKSCCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDE2</accession>
    <name>A0A232FDE2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000429">
        <property type="protein sequence ID" value="OXU28459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDE2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11965" checksum="8EF01E4ADA6C7EA1" modified="2017-10-25" version="1" fragment="single">MIARKSEMRSRYSGQRTRKNFEKRRRQAIATEDFFLLLLRHCGHLSPGCSCDFQEIKGLRPRSMAKIIDVAFPRIPPKASCRSPSWSSRKSHFEAQKDSPIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE44</accession>
    <name>A0A232FE44_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000410">
        <property type="protein sequence ID" value="OXU28597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE44"/>
    <dbReference type="STRING" id="543379.A0A232FE44"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7643" checksum="17E962342B0D4864" modified="2017-10-25" version="1">MYGIELVFLHGACVYNELQGTFVDFECTCLISACIASRPGQCGRSDGYILEGKELEFYLRKIKSKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE65</accession>
    <name>A0A232FE65_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000343">
        <property type="protein sequence ID" value="OXU29051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE65"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="44" mass="5400" checksum="C8790B75A20D18EF" modified="2017-10-25" version="1">MVLNMYNKKKKLRECAPTFVFSVSPTRKWHFSRRIDVPYTRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEH1</accession>
    <name>A0A232FEH1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sedoheptulokinase</fullName>
            <ecNumber evidence="10">2.7.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbohydrate kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_005663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a modulator of macrophage activation through control of glucose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16802"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.14" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01000331">
        <property type="protein sequence ID" value="OXU29161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEH1"/>
    <dbReference type="STRING" id="543379.A0A232FEH1"/>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000111">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000132">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU29161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="464" mass="50726" checksum="7E0BAF616A02C81B" modified="2017-10-25" version="1">MSPLVLGIDVGTTSVKVVIVQKETQLILANQSKDTQANVPSDLGIEGNKQDVPKILSAIHNCVSRLPKDLLRQVESIGICGQMHGMTLWQLPNECSYKDNGVFKLDIDKDKVSNLYTWQDGRCDIDFLNSLPKSKSHLPVHTGFGCATLFWFAKNKPEKLKKYDRCGTVQDLVVSLLCDNDDVKMSSQNAASWGYFLTEPREWDREALEAGGFPMHLLPSEILSPGQAAGTLAHNWFGIPAGVTIGVALGDLQCSVFALLKEPTDAVLNISTSAQLAYVHPTFRPETINESQKIEYFPYFGDKYLAVAASLNGGNTLATFVKSLQQWTLELGFSVPQSKVWDKLIALGKDDNSISDMTIVPTLLGERYAPDQTASVTGITLDTLHLGNIFRALCSGIIKNLHDIMSREELESVGICRIVGNGSGLVRNPVLQKEVSRWYSLPLELGHTGDAALGAALAMFTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFA8</accession>
    <name>A0A232FFA8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000320">
        <property type="protein sequence ID" value="OXU29243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFA8"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026142">
        <property type="entry name" value="Pro_pase_1_reg_su_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14895">
        <property type="entry name" value="PPPI_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="449" mass="51915" checksum="8334A85BF3551F6B" modified="2017-10-25" version="1">MEEKYFIWDEIYEGLVLSGPSKIEDEKKKDSRTKSQVTEAKIYCPHKRLIFNFKETLNFSEQTKFRKYYLRPQSSPDVILLQDVKDLVLYLLSSPSSLELIGFLHLPIVDRFLRALILYLQHYLTTWSELGAKRAATAKRASNPLAGGARVQRAEEMRALRCLLAREYTDLLMGCQSNARRYHHAGGGVASFAQSNPEKDLRIYEGLIQFAHRVAWIALERKQKELIEVEMHRLFRTESFNTAKRKCGESCWEVPEDERWILYGPRMPARRKIRSNSPLPHEILYTDCDYRILSVGFTNDESRDPRITYLQNALLAREQDLPRLGIKVGILGFPRTDFDILLIPQTSEDDLQAMLDDAPVEDVEKADDYETLMPSCSGPDPESTKPFPLDRSSPRCVGDEKIRNDSRKKWMMRELMRASSNYAEITYACTYGSKHNESLDSSVFPLNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFL2</accession>
    <name>A0A232FFL2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000286">
        <property type="protein sequence ID" value="OXU29485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFL2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9801" checksum="D9A202D5D4677635" modified="2017-10-25" version="1">MQCSDGVTSTPRLRKITRSLSRSAIAAVAASLTLIASRLWRPFERSLFHRTKRKDSRGENEDDHMRAYVYSKNNENKKIYKRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFS6</accession>
    <name>A0A232FFS6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000266">
        <property type="protein sequence ID" value="OXU29614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFS6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="13377" checksum="FE8D1A7999CA5E04" modified="2017-10-25" version="1">MELYACIRFVEENLYSAKYYYIPITSVYCNKHDTDHIVPVDLGDYDTKNKYYIFWNDGVNEDKYLGYIVSLGESKEDAKNRTLTREKRVIIPKKLTSSDTSDQEIEENNSKNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFY8</accession>
    <name>A0A232FFY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Follistatin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000299">
        <property type="protein sequence ID" value="OXU29368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFY8"/>
    <dbReference type="STRING" id="543379.A0A232FFY8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012782488" description="Follistatin-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Follistatin-like" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="185" mass="19971" checksum="BD1FECC15D515F37" modified="2017-10-25" version="1">MKSVLIVCLLAVYQVQAQLTCSTLDCRPGYHCKDGKCLPNTPKLTCSTLDCLPGYHCKDGKCLPNTPKLTCSTIDCRTGYYCLDGKCIPKATCETIDCRSGDICIDGQCIPKLTCATVLCRIGYICQDGQCFKKPPSGITCANVKCMSGYVCVEPARCVKKFDKKCFTVKCSAGHVCVNGVCVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGI6</accession>
    <name>A0A232FGI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HYR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000257">
        <property type="protein sequence ID" value="OXU29673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGI6"/>
    <dbReference type="STRING" id="543379.A0A232FGI6"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="13756" checksum="BBE61EFF83FE2092" modified="2017-10-25" version="1">MLFRDGLARAIWVIVCEKYGINTSATERARTTTSTEAPRPYIRCPNDLDVELPPRRATARVSFPQPKTNVDWYRYVDASPAWGKQLQADLPPGLTMLTFTAWSSATNYTNACRMMIRIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI23</accession>
    <name>A0A232FI23_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000164">
        <property type="protein sequence ID" value="OXU30391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI23"/>
    <dbReference type="STRING" id="543379.A0A232FI23"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="8521" checksum="5DB5BD5929C100D1" modified="2017-10-25" version="1">MLAARAQAIARLKESSAYSHLDETALLGRLMAYCSRESHSCVEKDAMISFVKLRILEPDEKSVLRGETLRQVIISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIC0</accession>
    <name>A0A232FIC0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000177">
        <property type="protein sequence ID" value="OXU30270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIC0"/>
    <dbReference type="STRING" id="543379.A0A232FIC0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="20147" checksum="AE64C39EC9C90229" modified="2017-10-25" version="1">MISPGMSSCEHSLNTLRYADRVKELAVTDPSETRCSTEENETNLQVNENSNNSALSDSDLAQLISLNEGELSQDLYTFHEAVSALQMLEEEVLDMHKLVMDDTTKFLNVAHDIFSITHEVDYDQEDYAKKWEDVLLKQRNILNEALNQVTKFRGQLLQEEQISQKMTRTKNLKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKI0</accession>
    <name>A0A232FKI0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000115">
        <property type="protein sequence ID" value="OXU30827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKI0"/>
    <dbReference type="STRING" id="543379.A0A232FKI0"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="10">
        <location>
            <begin position="104"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU30827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="449" mass="51046" checksum="0CD5353BD13ADB0B" modified="2017-10-25" version="1">MHRTLISCVFWQCSVYVKQCIKQLLLHEHLTLSNSAIFRTMDNKKEVEDEKKDSSSSVEEHESSSSSLDQAEGGDSDTSMDKIRKFLEQKLHIFDNNSSDHVEKVLTETTVDGVVEFIKTHNVKKIVTMAGAAAGIPDFRSPKSGLYHNLDKYNLPHPQAIFELDFFKSNPEPFFVLAKELLPEGYKPTPSHYFIRLLHEKGLLLRHYTQNIDTLERLAGLPEEKLVEAHGTFHSGRCLDCQASFDLPWMKEKIKKATVPKCEECSEGVVKPDIVFFGEMLPDRFHRLIDQDFPEAELLIIMGSSLLVQPFASLVDRVKRSCPRLLINKEKVGMQDRLSRFLGISSGMNFDSSNGRDVALLGECDKGCQLLAEKLGWGDELKDLIAKEYERLDTETYNFTNCVFLCFFVACNQERSSVKLYSDSTHVSTKSRLTYDSLEASTRSDFVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKS3</accession>
    <name>A0A232FKS3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000089">
        <property type="protein sequence ID" value="OXU31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKS3"/>
    <dbReference type="STRING" id="543379.A0A232FKS3"/>
    <dbReference type="OrthoDB" id="5860767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22100">
        <property type="entry name" value="F-box_FBXO28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="369" mass="42520" checksum="319D41123D6036CB" modified="2017-10-25" version="1">MKEEGGYRLHLIELPDIVLEGILSNLTYDEIAKNRVVCKTFDNICKKLLNRGFNLMEKYHAQCLKAVKSQLPRRESERRSHPLARHCDILTAIETRISMLSMTFTKYVDLNLCCFIPGKVIDEIFRVLRLIRISKTPPRTPEILQELRDISSMAMEHFDEKILPDFKHSLCTSVVSNVNSYDNLMIAHHSSGSKSSSLPHSLSPDKINQTFKKIYSRTKKNKMTVLCVKGQISKMKLRMNRQSFQMRLQSLKIQEHAKKIVDQDAQLAEMRKHLEEWEQKLADVTAELSRAREESQKPDTLDACKRKVSDIPSPNLETSLLKTKELQAKKRKLIVERKSSSDAQDVKFKKFMAELLSDSSIEECPASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLQ7</accession>
    <name>A0A232FLQ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000038">
        <property type="protein sequence ID" value="OXU31681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLQ7"/>
    <dbReference type="STRING" id="543379.A0A232FLQ7"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, DROSOPHILA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112:SF16">
        <property type="entry name" value="SIX-BANDED, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="207" mass="22298" checksum="09BD35A770DCB6B1" modified="2017-10-25" version="1">MHSTLHEDQDGHVRAEPQDDPASAKATRMFAVGEVVWGCARGNAAWPGKVEAIGALPTSLSSSPGGTNAAAAATAGPTVWIRWYGSQRETGLSQVAVKSLKSLSEGLEAHHRARKKFRKSRKLNTQLENAIQEAMAELDNKPKLQSQPDNSISKPKPREKLIAPATLVVPAPQQQQQQRTIGLRKTPGRKVPQVALAVAVAPRKQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNM1</accession>
    <name>A0A232FNM1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000014">
        <property type="protein sequence ID" value="OXU31967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNM1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="35" mass="3803" checksum="B0F7359E76670FFD" modified="2017-10-25" version="1" fragment="single">VLQRSSKHVLAEWGDRAAVDVPGLLPQAPTRGLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDC2</accession>
    <name>A0A232EDC2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006867">
        <property type="protein sequence ID" value="OXU16356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDC2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="201" mass="22689" checksum="B922EE62D5E0646C" modified="2017-10-25" version="1">MSNKFSKINEVILNVHLPHTVETNDSITMLLSIAKESFAAAKKNNLQKLEKLLEKKCGRQCRRWNNTIALCCVNNGNLNMVMAPLHVATLKGQKEILELLLKHVKLEKLYDFVNTNTTTTSGATALHVAAKNNVKKGEAKILNRLNEMNPDELTATLNARDLRGNTLLKVSIINKHKSISSGWKWKHQLRLPTLFPNPKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDL4</accession>
    <name>A0A232EDL4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006197">
        <property type="protein sequence ID" value="OXU16441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EDL4"/>
    <dbReference type="OrthoDB" id="7553767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="50195" checksum="6F1111F3BD11F68C" modified="2017-10-25" version="1">MKNKINDLNRRMVVDVEESNSNISARLTAVETLASNISARLTAVETLASSIDERLRKMEKVQNSMFKKMRDMTKRNSPKVRTKPSCFPFKSIADLLEFNNATDELFDDVVSISXPLRFASLFLTHTLAVALFMFKMMRDMTKRNSPKVRTKPSCFPFKSIADLLEFNNATDELFDDVVYYLAYLGGANLQDKASLYFKCCIELDEDLFRNLCWHGSKINHVKVCRHVLPRLAKDAMEKPTLDKFSTAMTKAIKNANEGYRRKRSAAEPLEEQLPRRRSRVLLPRNNPAVVVIRQPPLHQDDNYEDVKPLQPEHLIPANVDREDQYQDETQYENETQYEDETQYEDETNENEDQHEDETNENEDQHEDETNEDQYEEEGKEPNKYQQEEEPEEEDYVRNINVNAPYVYKQELDSNEEDNLDEDLDLFANIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEJ6</accession>
    <name>A0A232EEJ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005288">
        <property type="protein sequence ID" value="OXU16786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEJ6"/>
    <dbReference type="OrthoDB" id="7680010at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12115" checksum="C8D45160913C5281" modified="2017-10-25" version="1">MYEESCCGLGGNVLAMRIVKDGLESLRRFCGVINFPAPMQNSSFTKIRKQLLNVTCDVAHKFMTDAVEEEIKLSQNSSKETVEVDDFNQEAIRRLSMINLEQEDIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEL8</accession>
    <name>A0A232EEL8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005282">
        <property type="protein sequence ID" value="OXU16795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEL8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10770" checksum="78FBDA602F242903" modified="2017-10-25" version="1">MCKGEQFIMNCKAFITKNPKERKQIVIKKGFALTAYLATRLTSVKMGRAVKFVRVTTTLYCTTKREDRLRVMQGQIKILRMKRRTIAQFIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEU0</accession>
    <name>A0A232EEU0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005222">
        <property type="protein sequence ID" value="OXU16863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEU0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="111" mass="12834" checksum="37625FB42F1F2074" modified="2017-10-25" version="1">MSYWKHLSTIELEDNQVAAEITSEEDKLSPKKKSDSDKLVERAEQITDEKPLVTRLVRTVSLAALLMLSWVPFFQGKNEYSLPYYKLTPLRGEDRNSKMENSSHLGFQQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFH1</accession>
    <name>A0A232EFH1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005040">
        <property type="protein sequence ID" value="OXU17078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFH1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="28" mass="3344" checksum="308B1009512191EF" modified="2017-10-25" version="1">MLINTVLLVHLDRQKNILQNHPLLKYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH27</accession>
    <name>A0A232EH27_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01004604">
        <property type="protein sequence ID" value="OXU17667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH27"/>
    <dbReference type="STRING" id="543379.A0A232EH27"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF6">
        <property type="entry name" value="HEAD-SPECIFIC GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="11">
        <location>
            <begin position="266"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU17667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="475" mass="53545" checksum="0593E369106AE50F" modified="2017-10-25" version="1" fragment="single">YRITPEHFSSETSTASTTTTTTTTTTTTTRRTDEDEDDEEAEEKERHASHLLSHEAADLRMGVPSFCKAFPWHFVVDRNLEFVQLGVGFMRIFGHQLNRHGRDISTYFLFTRPRGVTLTFHEILKRSNTPFVLTLQKPPGADQFQAEGLEFKGQMVHCPESDSILFVSSPFLNGLEGLTGRGLFISDIPLHDATRDVILVGEQARAQDGLRRRMDKLKSSIEETNRAVDAEREKNVSLLHLIFPPDIAKRLWLGETIEAKNYADVTMLFSDIVGFTAICSTATPMMVINMLQNLYQQFDSYCGQLDVYKPLVETIGDAYCVACGLHRNTSTHAQQIAWMGLKMIQTCTQHSTHDGKPIKMRIGIHTGMVLAGVVGKKMPRYCLFGHNVTIANKFESSSEPLRVNISPTTYEFLMQGPGFILEERSRDNLPKEMPRDTEGTCHFLNDYKHPEVEENEPLDTHIQAALNELGINGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHN0</accession>
    <name>A0A232EHN0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004485">
        <property type="protein sequence ID" value="OXU17831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHN0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="149" mass="16551" checksum="97A0CEFC2A31D025" modified="2017-10-25" version="1">MSQIDLSTGNHSQDPPPSYEEVCSSLTPGKLINSEEVTTGETTQYHTPTAPACEDIQDGISENVVLENRINTGIPNSGFPQNVRAKEGLEKAATTRRAPTKAELYRNLLELEESERRAELAEEHLKRIKREIDAMDDCSGFCNCNKINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIE9</accession>
    <name>A0A232EIE9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004249">
        <property type="protein sequence ID" value="OXU18149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIE9"/>
    <dbReference type="STRING" id="543379.A0A232EIE9"/>
    <dbReference type="OrthoDB" id="7701690at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36927" checksum="C293062E482773B3" modified="2017-10-25" version="1" fragment="single">GEHGEHDKQHHEGHHEEHGGHHKKHHDEEGEHGEHHEEEKGHKGGKFGEKKGHKKGHKTSGYHHKVHKDEYHKEHNRISCYVKKGRYPIGAMRSGTLACLLAVALCLAISRVDGRGIAGHGGESHEDHHSEHGDKGHKGYKNHHEHHKGEKGHHDKEGHHHHYDEDGGHKKHHHHDDGYHHEHHKGEKGEKGHKFHEKGHFGKGHSTKGHHEVHKLDEFKKDKEFYDEHHDHGHHEDHGGHHHEHHHKKGGHHKKGHHHKGHHEGHHGKKGHHEKGHHHHDHKGHKKEGGGHDHHHHHHSYGKKGGHEDHKHWHHKKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIM7</accession>
    <name>A0A232EIM7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004236">
        <property type="protein sequence ID" value="OXU18161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIM7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="392" mass="45688" checksum="CCC17D7A60111237" modified="2017-10-25" version="1">MNLLLRYGAEFYPRRSYMRYITDRRPPGSTSQFIVYCLAREISEKRFSKIVTGRYHPFPQYTMSTYQKKLRMIGMSIPYGDQQETLRLIKSLAPTMLPTKMTMIIHQCILGDKIKIIEYSLDNLYEQRLLRHCSWEGTNLVHLVVESGSLKAVETTLSREINDINGIDGNGYGAEFYPRRSYMRYITDRRPPGSTSQFIVYCLAREISEKRFVNSDDLRALKIYHPEDLMENPIKNFYNVDPPFLEDRKRGTNKEGPVMEITKMLAYLGGIPNHQAKKNKLLQGDRILTRSSYLEKSVNIVKPDRNNCKDFVDKYIRVLIGETPSQVLELNALLWQFDIDLTYQRGMDLFNQDIITRDERILQFLLDAGIKPENDLCPYIVAITSQFSNYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIV7</accession>
    <name>A0A232EIV7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004163">
        <property type="protein sequence ID" value="OXU18262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIV7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="13297" checksum="31A19399303D1558" modified="2017-10-25" version="1">MLGHTPATCFPSEMLDLVKTLFSYSFSTVIHVLVVPLCISYMSLNNGYFSTNLKGLKNSVTRHFSILERGFCMVLNMYSKKKKVAGVCPNICLFRFLQPENSIFPVEFLIYIWQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIX6</accession>
    <name>A0A232EIX6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004155">
        <property type="protein sequence ID" value="OXU18282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIX6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="11336" checksum="384DA1201596D3A6" modified="2017-10-25" version="1">MLQKSCGLKSIIKLASDTDADCIWIIPQSVRFTRPLQMCFEKENNATTRKKYDRLQNEIKNLKRHRFKWSNGKTIHNFDFRKKKYKEIFLIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIY8</accession>
    <name>A0A232EIY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01004139">
        <property type="protein sequence ID" value="OXU18315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIY8"/>
    <dbReference type="STRING" id="543379.A0A232EIY8"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000008">
        <property type="entry name" value="histidine--tRNA ligase, cytoplasmic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="176"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU18315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="597" mass="67697" checksum="E545F1F917970E07" modified="2017-10-25" version="1">MGSLQEMIKEQGELVRRLKSEKADPAKGFKESLGEIDRLFSNYSYVCGWKPTKNDTQFFNLCCTHENGGYGYWPHLKRWFDHIKSFSSEEQSKFPELKQSNCELASKISRLTTAFCGDIDEKIKEEVSKLLELKAQLGDENVGSQKLLLKTPKGTRDYNPEQMALRLSAMDKIVAIFRKHGAETIDTPIFELKEVLTGKYGEDSKLIYDLKDQGGEILALRYDLTVPFARYLAMNKITNIKRYHIAKVYRRDNPAMTKGRYREFYQCDFDIAGQYDPMLPDSECLRIIYEALKSLNLGPFTIKVNHRCLLDGIFATCGVPQEKFRSICSAVDKLDKSPWEEVKKEMVEEKGLDEKIADRIGTYVSKSGGRDLVEELRKDADLLKQPSAVEGINSMELLLKYCEIFKIMDNLVFDLSLARGLDYYTGVIFEAVLTGDNIGVGSVAGGGRYDNLVGMFDPKNKNVPCVGMSLGIERIFSVLETSIANRGMKTRTTEVQVFVATAQKNLHEERMLILAELWEANIKAEQSYKKSPKLLAQLQHCEEYGIPLAIIVGEGELKRGEVTLRNVKTREETSIPRANLVEELKKKLNTLDLSAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJE0</accession>
    <name>A0A232EJE0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004067">
        <property type="protein sequence ID" value="OXU18421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJE0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10628" checksum="76430C512C314836" modified="2017-10-25" version="1" fragment="single">SHGFEGDCFFFYTGFFYLGFAENFRHLSFADERVRDGWKSILTLVFPKMNYLFVYYNCLPLAKVCVAFRFAINSSLATRNKNTYFLETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK16</accession>
    <name>A0A232EK16_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003920">
        <property type="protein sequence ID" value="OXU18651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK16"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13174" checksum="9461CCDF70FA23EA" modified="2017-10-25" version="1" fragment="single">MAIPIEALHKSWVMSAEENEICAKLLFLNITLFPIAHSTVIHFLFVPLCIRCMPLNNGYFSTNLKGLENSVTRHFFDVGTWFCMVLNIPPELLLRYHGPTVDTWGVGFIMAEMWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKK9</accession>
    <name>A0A232EKK9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_016577</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003756">
        <property type="protein sequence ID" value="OXU18896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKK9"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF37">
        <property type="entry name" value="ODORANT RECEPTOR 46A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU18896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="386" mass="45441" checksum="E46171AFE652966C" modified="2017-10-25" version="1">MHTIHLPFTILKYIGIWKPNSWKSTWKSYQYDCWSLAVMMIMYSFVTTELIAVVKLISDHYDEISDTLFLLLTTAGVFIKSMNFLANRNNMAHLGNMLLKSCCIPKNLNELKIQKKFDDINSRFVTLMCITMVYGNIMTMMTIPLLQPKEHRNLPFNTWLPYDTRSNTLNYWLSYLHQGLGLACCGTMGVMIVNIITGFMQQACAQFEILDSRWRNLPKIVEIARSRWSDSAADEHENIMLRQHIRHHIHVYEYMNEFVKTFNIMILVQFCVSSAVITISVYQMSTKSLGLEWFMVFGYAVSMLTEFFLYCWFGNEVTLKSMDFALKIYDTEWNLLNIKSWKLILFVTYRTRKPIVVRCYNYIILSLDTYVNVSNSDINIFYFFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL51</accession>
    <name>A0A232EL51_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003652">
        <property type="protein sequence ID" value="OXU19048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL51"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="223" mass="24871" checksum="6322AA12F3822EE1" modified="2017-10-25" version="1">MLPAKKFTAVMEISAELLRRISRLMGQLITTRASEISPTLGEPIPLSVLLRSLEEAIRTTTELSLDQRAAILPALHAGREKPCIELELLPEEVKPLASSVTPPSPPEPTGEGEMAPPCPPPGTTPTPADRKNTATLQEKWAQFEANARACRRARQEAARKDKEAHRKVLAFAQWADIRKRAMLPLDFLDKVQKDVALQEHLDKVEAQEQKQEKKKEALKLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELM1</accession>
    <name>A0A232ELM1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003531">
        <property type="protein sequence ID" value="OXU19247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELM1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="8668" checksum="91C5A94544C27955" modified="2017-10-25" version="1" fragment="single">HPESPNQGRLLTLFYQVGESHQQASPHTRERGGNKHTSSAATNQKSLQTHQPGRRVIITMEERRCECTYVCDCARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM02</accession>
    <name>A0A232EM02_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003453">
        <property type="protein sequence ID" value="OXU19393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM02"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="228" mass="27328" checksum="FD8F8918EEEF67C4" modified="2017-10-25" version="1">MYSIVMQMQAELDEQLANFKPIKINLLRIKENKLGASLMDTEVLRQIERSFNIYYRTCKFPVINITNAAELNQWIETSYGIDKDQIYIKIRIPCVNEKRVQFHRYKPIPILAYIEPRSRYMLVHSNSHYHASYEEIQECKHGDQLIICPVQWFTFNDQNSLREHPIDEPREYRLQHLPNKSIKKNTLTTQSRQCHIEWSRIAKNLQRMQHRVQGHEYTKISDNNEPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM51</accession>
    <name>A0A232EM51_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003420">
        <property type="protein sequence ID" value="OXU19443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM51"/>
    <dbReference type="STRING" id="543379.A0A232EM51"/>
    <dbReference type="OrthoDB" id="10256182at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11686">
        <property type="entry name" value="UBCc_UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000042">
        <property type="entry name" value="Ubiquitin-fold modifier-conjugating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008716">
        <property type="entry name" value="DUF1782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR008716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR008716-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="20597" checksum="F09D708523C8D690" modified="2017-10-25" version="1">MVDESTRKTLSSIPLLKTKAGPRDSEAWSQRLKEEYLSLIKVSNNVYKTELLPYENNKKADNDWFRLQSNEQGTKWFGKCWYIHNLLKYEFDIEFDIPVTYPTTAPEIALPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGIGHAMALGLGPWLAVEIPELIERGVVKHKDNVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMH9</accession>
    <name>A0A232EMH9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003363">
        <property type="protein sequence ID" value="OXU19547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMH9"/>
    <dbReference type="STRING" id="543379.A0A232EMH9"/>
    <dbReference type="OrthoDB" id="5911912at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09455">
        <property type="entry name" value="LIM1_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09461">
        <property type="entry name" value="LIM3_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000060">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000067">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000069">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="225"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="280" mass="30725" checksum="56DD3276B619714D" modified="2017-10-25" version="1" fragment="single">PPCRSSSSSQQVKQTVQSQNRFRRETQTTTTCQSQSRTQSQTSCSLSSKTQSSVDPPNMSSLPDLGAGSCGLGGGNKAGTFAGSSAPNRGRGILNQAGSGLRVPLCAACNSQVRGPFISALGQIWCPEHFVCVNPQCRRGLQDIGFVEEKGQLYCEYCFERFIAPSCNKCNNKIKGDCLNAIGKHFHPECFNCAHCGKHFGNSPFFLEEGLPYCERDWNDLFTTKCFACGFPVEAGDRWVEALNNNYHSQCFNCTMCKKNLEGQSFYAKGGRPFCKNHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENA8</accession>
    <name>A0A232ENA8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_002000</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01003183">
        <property type="protein sequence ID" value="OXU19849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENA8"/>
    <dbReference type="STRING" id="543379.A0A232ENA8"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060003">
        <property type="term" value="P:copper ion export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000031">
        <property type="entry name" value="Probable copper-transporting ATPase HMA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1018"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU19849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1122" mass="122372" checksum="C67846690C628E30" modified="2017-10-25" version="1">MSAGKNEWKYLFNETKIDCENEGSALQELNRPREGQDEEGLSSCVIGIEGMTCMSCVNSITGMLSGKNGVEKVYVSLETHEGTVSYDPKLITPQEIADIVEDMGFGAVVKKVNNDVLINNVDSVVLTIKEGSPAKVSKKSSPLKECIERCFLHVDGITCNACVTAIEKHCKKLVGVKNVLISFISGKAEIDYDSNEIRPADIAASITELGFPALLINEKGSQIKEVEMHITGMTCSSCVSKIEKTVKQLPGVQSAMVSLVTQKGKINYDPSKISVDEITDCVKKIGFGVSTKRNEAENRQYLDHRLQIQKWRTSFLVSLAFGAPSMIAMAYFMITMSYMEKEEDMCCVLPGLSLENLISFILSTPVQIFGGWHFHLQAYKAVKHGTTNMDVLISMTTTISYVYSVLVLVTAMIMEEITSPKTFFDTPPMLLVFVSLGRWLEHIAKGKTSEALSKLLSLQAADAVIVTLGADNEILTERLVKIDLVQPGDILKVNQGNKIPVDGQVYIGQSSCDESLITGESMPVPKKEGSIVIGGSINLSGPLYIKATHTGEKTTLAQIVRLVEEAQMSKAPIQHIADKIAGFFVPFVISVSALTLIAWTIIGYINIDYLMLMGDDHMHHSNRNRDEVIFQNAFRSALSVLAIACPCALGLATPIAVMVGTGVGAINGILIKSSDSLENAHKINCVVFDKTGTITKGFPTVTNIGLFTSNGAFNIGKILVIIGIAELNSEHPIASAIVHYVREVIETELSGRCSNYLSVPGCGMKCKISFITDTLKSVAKSSKITSFVNNLQNNVKDPLELNDVLIDFSQVSPEQETANSEQESQLNALNADNSEVYEVCIGNREWMKRNGITIPQDVENTMRKEEDMGRTVVLAVIDGELSAIISVSDAIKPEAHLAIYTLKKMGFEVILLTGDNRLTANTIAQQVGIEQVFAEVLPSHKVEKIQQLQKQGKKVAMVGDGVNDSPALAQSNVGIAIAAGTDVAIEAADIVLMRNDLLDVIACIDLSRETVRRIRLNFLYASLYNILGLPIAAGIFTPLGLRLQPWMATAAMALSSVSIVGSSLLLKLYKKPTRERLENQEYKRIARFAKRNMQMIDNPTKASINGSSLSLSKIRYSNLSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENG9</accession>
    <name>A0A232ENG9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003168">
        <property type="protein sequence ID" value="OXU19877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENG9"/>
    <dbReference type="OrthoDB" id="7681072at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="157" mass="18009" checksum="5AD55C8BB711984C" modified="2017-10-25" version="1">MMSNEQTRPYKASKDSVKKAMELFNNVKKTTKRKKSPENEDDSNKHSQFCNPIIGSSKKNLTALAFSPSFALREMRLCLMKHDWVNLQRLFPLLLELSSDKETLVWRYALTILLHSPMSSGAHVENFLNSCVGCQNDNLNYVLDQLITLRVSKQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENK2</accession>
    <name>A0A232ENK2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003149">
        <property type="protein sequence ID" value="OXU19906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENK2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669399" evidence="1">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12164" checksum="108DC672F6A3BBB3" modified="2017-10-25" version="1">MSIAIKELLLSLGVMLLVTPQLCWAYRLPYPCPDEKKHHLPYRVDGPAKETYIKVLTPIPPPSPSPPSPPPLYDCNEDVYDNIADQYKEPRSGYLQKYVLYNEEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ96</accession>
    <name>A0A232EQ96_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_001970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002819">
        <property type="protein sequence ID" value="OXU20502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EQ96"/>
    <dbReference type="OrthoDB" id="7549390at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU20502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="12014" checksum="92CCD8654BC4AD39" modified="2017-10-25" version="1">MPKVCCVPTCKVRSDDFDSLKKTFHTFPADKDLRQKWEQQLKAEFMDLSLPKYSYVCSSHFKPDCFYFSGLCANLRLKKGSYPSIFSSXPQNANFIVDFEVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQK5</accession>
    <name>A0A232EQK5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_014395</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="NNAY01002745">
        <property type="protein sequence ID" value="OXU20644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQK5"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="383"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU20644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="682" mass="77774" checksum="58A6B906CDDF57D7" modified="2017-10-25" version="1">MINENIFVFYRKMPALKLFGRKWLAATDDLVYPGLFEIFIRIVWLVLIGIACLRYYGETWKCRSGGDLVRVFLIGEMAILGIVTILIIFIVNHSARGSIADTYARRYVQPLLTVKVLLIPAEVVWNILGTIWLFSEAVECSSEHYTTGVVEALVIFDWVLIGLTIFGLALIFDPLGSLGLEDKELEDSVEHGKISRIWLRRFKFFWWMRRDESASETFQHVAGLLSALFRGTDLVPSDVMAGCVLLRVRQKRETLELRRLNILERPKYTTDGVSIFAGAPDWMSLEWAHHYLQLAISSYGWLFVIYRHACTGCFRLVREMTCCACMRRKRNVVLDDNCCLCSLSGVKTLSKLSEDDILFASFRNHLCEIPFVVLADHKTSSIVIVIRGSLSLRDLITDIAAASDSFEPEGLPPGSMAHRGMIIGAKVLLKQLDQYKVLEKAFKMYPHYDLTLTGHSLGAGLAVLLGTLIRPRYPHLRVYAFATPAGLLSRDAARVTEEFVLSIGLGDDLVMRLSVDSMENFRTSLLITLQACRLPKYRVVLNGFGYILFGVPDRDLNRTWRNGNTINSIPGQLPLLSETPSMRPTETILERDVTRRRYSKVRLYTAGRILHIARCKPASKEKKRFDNRKKNKDKKFEMRWAHPEDFMELSVMPRMLLDHLPENLEEALAILVKQQDELPFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERJ1</accession>
    <name>A0A232ERJ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-cysteine N-palmitoyltransferase Rasp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002610">
        <property type="protein sequence ID" value="OXU20951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERJ1"/>
    <dbReference type="STRING" id="543379.A0A232ERJ1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="60554" checksum="2B6EEA7BB997EF0B" modified="2017-10-25" version="1">METKQAMTKLSRFETWLCVAGWSGAVFYSIYCVHLSTDRYFRDYDDAYSDFAPGWSFVKRKVDVSDEEWRIWIPLMFQLVPWIALQVFVSQCLKILCHNKTLLCSWYAALSVIFLWNYFGLLSTLCTLLLPCISCLLASLRSKVISWIVHTATLALIYYAKVSDVIFREWLMLEDEEYFMLTAAICWIQLRSISYSIDSIESYKHVDVWGFVQDLLQNLAYCLYLPTLFLGPVIFYQQFLDGVNKPFTQWGKEKSLRIFSSLVRYTFWMYFTQLALHYVYFNALRFHPEFVISLRPWAFYGLGYCMGQYFLNKYVVVYGLTSTVCRAEDIDAPPQPKCIGRIHLYSDMWKHFDRGLYKFLLRYIYIPCNPKSAIGKFFASAVCFTFIYLWHGMHLYIFIWAFLNFFGLFIETIAKSISGFFYQNIIRISISPQNKRRLECMISSPLLALSAISNFYFFAGDEIGHMYIYRVFRESWTATATLLLALYCCCQTSTEVKQFEKGKVLNESKDKNKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERJ4</accession>
    <name>A0A232ERJ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002585">
        <property type="protein sequence ID" value="OXU20989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERJ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19335" checksum="17172B4C6AF3911E" modified="2017-10-25" version="1">MCTRYAQYKEYVARENFGRGMRDDDYIDEDEVKFIPFCPRVMTATTTLYVDGYNRIPVILGLIDCFKVAFNRPIDNEEAFYSHNTGTSKLLQTPIILFDTSESVLVATQTNSYGATVILNDVWSGNGYTLSPLLLTSIVNAPEGSPEAQYTREHESTRCKIEQCFGILTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERM1</accession>
    <name>A0A232ERM1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002614">
        <property type="protein sequence ID" value="OXU20936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERM1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="856" mass="99571" checksum="9E5B86338FE8CC6D" modified="2017-10-25" version="1">MKNLLYWTTSTERGRYRIKQKLIKMAPWKDHQENINPLQHRYYSSVKSARPRHTLPISKPSCTFSKSQIKIIKNFERNTSSLTPSSKSKFSQRRDALVSNKLAKPPISSGIPPNVQNNIQSHPNSETAEVVNQQQEVHKHASPSKRQRLEKVNYANDPHTSEERIEELHNGVQMQYHTNIQATTIPIPLNLTVHTGAEVPPKLANTPSGLGREQQNNGTYSFAMKLTQNNTEDFFESLKLDNIKSRKKYLTYLESEYRNNVDGITYSEAMQELKKEVNILKQSIERSERIRLDIAETKAILRLGKYICKKCKSGYEKPGNIFNHILASHPEIVEEYKLAQMNHTASTGNGASSLSSHSHSIHSQITLMDSTVSPRVANAAFKLQKENSNQTQTERNPARKNIPVSSRCNVNTRPDHALAKTTNLRMYLQTTAEIRQDNPLWKRIEINFVPRKPVDFLGHKSFVLFEKNERMIRKWMRNRRSNNLTTHTNKNINITPRVVSGKNKTVQDGSVQINKYYLDLLYNKAELEQINHCYANKKIMDLCESCLNKLVEFQAKQYAVSKAAYDEYKKVTESNSLSNEKKRSKIKKIINTRDEYSLIRERLQSVKAKRGFFKLNEVVVQYNRKYFLLLQKAFNDTNIQDYVQLDESNRPEYNLGIYCSKLMDDIVNEFLVQVTVTCMNFAYHKRQVTLTKELLSQYRALFKMTNKDAKYLEPSSRMEFYFEKKYMNLLPKGRNLEVLIIDCLLRHCFGDENTMHESLDELIFEHLKSPQPIFKFLMYMKFTTPYLAIIRVLLLAFLFQLSVEVLKLKKEKRNKCLVTFEELIEACEIVGVFGSSYIHNLKKSYTQYFEAFVLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU09</accession>
    <name>A0A232EU09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="7">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSAR_012185</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Alberta</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="25">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01002209">
        <property type="protein sequence ID" value="OXU21797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU09"/>
    <dbReference type="STRING" id="543379.A0A232EU09"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140290">
        <property type="term" value="P:peptidyl-serine ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4080.10:FF:000001">
        <property type="entry name" value="ADP-ribose glycohydrolase ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="25">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OXU21797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="357" mass="39592" checksum="8CE3367995B9197E" modified="2017-10-25" version="1">MTKIDLSLFRRKFRGSILGVLTGDCLGSPYENEKLSSGSKLVLQKSFDKLEGPPFKAPVMQFTDDSAMTMSLAESLIEKKDLDLVDLAKKFVKSYYQEPQRGYGSGVVTVFQKLRGSKFSDVLLPAKEQFHGQGSFGNGAAMRVAPVALFCYNHYDNLREFAKKQSLITHTHKIGVDGAILQAIAIQQSIHIHPDDQLNVIDFVDELVNKMNFVEEDEEGLDLVEAQPYKSQLNLVKKLLQEEGEENPIDDKVIKNLGNDISGLRSVPTAIFCFLRAQKPIKGIKTENPFRRAVQYAISLGGDTDTIGSMTGAIAGAFYGEEVISPNILQHLEASTDFKDLADDLFQVATNMEWNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU10</accession>
    <name>A0A232EU10_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002192">
        <property type="protein sequence ID" value="OXU21841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU10"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="79" mass="8743" checksum="497CC15E167077F8" modified="2017-10-25" version="1">MSILPLQVRLVWAGSYTAPDIVRTSQGCIIDSEILHNGIIILIRLFNIIIPLCNVAKFCIAILRQYSDDIGCCRQAGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUL6</accession>
    <name>A0A232EUL6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">trypsin</fullName>
            <ecNumber evidence="9">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01002127">
        <property type="protein sequence ID" value="OXU22006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUL6"/>
    <dbReference type="STRING" id="543379.A0A232EUL6"/>
    <dbReference type="OrthoDB" id="10051896at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF97">
        <property type="entry name" value="GH13245P2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0222">Digestion</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011991522" description="trypsin" evidence="10">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU22006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="244" mass="26945" checksum="820628F0FA5F866B" modified="2017-10-25" version="1">MKFTYFWLLAISGANLFVDAMHGGDYFPIKDVPYMAQLYFEAENGMISYCGATILSEYWLVSAAHCVGLKGMVINQVRVGSTFTAEAGNVINITRIIVNGNYETNNIWDSDISLIKLQSPIEFDEKQQPIHVAREPPKVGDSITISGFGYSYRGLMGESLQVGHVPVIDDETCRVNYTITKNMFCTSTSKIDLCYGDSGGPAVLDGKLVGIVSQGCEITAPNVFTKVANFYNWIIKHTGIKYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUQ9</accession>
    <name>A0A232EUQ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_008547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01002108">
        <property type="protein sequence ID" value="OXU22057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUQ9"/>
    <dbReference type="STRING" id="543379.A0A232EUQ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="74"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="461"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="809" mass="91337" checksum="87FB74C991A3BBE1" modified="2017-10-25" version="1">MFYKYNKFCINTILSKASVLSKIMYVLVVTLLALSSSNLVLAEELGADLSCTEFKDDYVGSVFYVFSSKPTYDGANFYLASKDSVDGVEINKNDWKGLESDSFDLSRKTYFIIHGYIDDHKKGWIRKLKRALLDTNNVNLIIVDWSKGSQTWNYVNAVQTTYLVSQDIVRFLENMRIEVSQFKNFTESHLWTNLYLIGHSLGAHISGQVGHILKTKKSSFKVERITGLDPAQPCFKNINSSLSLDQNDADFVDVIHTQTGNGEKISGFGLQKPCGHLDFYVNGGVMQPECEIKSVFYTELNKMICSHNLAYTFFTSTVKNLKTANCKLLGYQWDGTYKHALEISHEVQKSNQCSNCLEMGINAVNHQTQIGRYLVITSASTPYCQLKNDDEALITKAIDLPHYFLSCHQTQMKAFFASLLTILFCHVSAEEPVNLTCTELKNTFFGSAFYVFSSTPTYNGSDYYLQSKNNEEGVKIGVNNWSTINSQGFDPSRKTIFIIHGYIAHRKKPYIIEMTKQLLDTNNINLIVIDWSKGSQTWNYINAVQTTYHVAQDLVKFLQTMKEEVAKLNKPASEEWKNLYLIGHSLGAHISGQTGYLLKQRDQSFKVERITGLDPAQPCFISVEQSARLDKSDADFVDIIHTQTGHGNGINAFGLENPVGHIDFYVNGGVMQPECEAKSIFYTEINKMICSHNLANYFYAETVGYSKSKDCKFVGRSWDGSYSDAVRILDDVEKGSSCSNCPEMGLNAIHYKKNTGKYLVITSTKKPYCQLKTDDKDQLIKGFGRLNTTTVLFPASTFDPETIFEDWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUV7</accession>
    <name>A0A232EUV7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002087">
        <property type="protein sequence ID" value="OXU22115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUV7"/>
    <dbReference type="OrthoDB" id="7684052at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="693" mass="77131" checksum="9CA55BE323AC7581" modified="2017-10-25" version="1">MALNKSNKSTPSSRSGYLRELTASAGKTSNFLLPVRIKVTPQHNSTLAPLSGGKKNHTKMMQPVLIKDLLQSTQKSKSTTLASVSTQKKKARAQRSTQPYLNTQSCYKPKGNEDAESSFLGRKSFGGNKVRRQLYQALDSPQRSAIDGKENTAKNVKPRVKSTRDSEVPAAKSFQMLNKSRKSLLLPPNSIRNSIIRKSGNFKPPGKQGVKTNASVVNKSTKDVSRVTEAKLVKNNLKKNVQKVQDDIDMETDFSSPDADVHGMEESCVTRDIYTMTSPMRGEAASSKSLFNLSKLERPSVIVKSATKKTNDGEAPCLEMQNLNINPTQSYSHCPEFDFSQINCSDTDGIMQCKAYLEQSIQACEDQAFKLKQVLNFVNALFVKTKTMPTKETVNIQTDEQIRTDDKFDISSNTIVNSQNSSDVTDIIDKSLEKKEITDDVNSLSTAKPEIKVYVDKEDNGIEATEKLPIPIKILVTQADLNQEAKDTSSDTLSEMARLSTIGEVSCEGDESNKDESRKEEKDEKESENKENIDDSSPMLLTPTVSPKTPKTPRRRSVMPGSGERRRSARLAAKRRSLSVVSDTESDKQDSFTLLENELNVVHAVKVSSKSLPASPMKAPMTPGCIRQWDKRVERPLREYMALKMNGTFLVTPDVKRFQSCLEPTDTPHSRKSLSRKIFMELCDLYAESPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUW1</accession>
    <name>A0A232EUW1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_002317</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="EMBL" id="NNAY01002085">
        <property type="protein sequence ID" value="OXU22127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUW1"/>
    <dbReference type="STRING" id="543379.A0A232EUW1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA01020"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="17">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU22127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="367" mass="42353" checksum="12667D67506D1398" modified="2017-10-25" version="1">MAKYRININQTIKNLPPVYPNGWFGLLDSRKLKNGQVEHVAALGQNFAVFRTESGVARVIDAFCPHLGANMAEGGKVIGEELECHFHSWRFCGESGKCTTIPYSKTVPPNIKVKVWECVEVNGVIFVWHHAENVSPYWWPEQEEKIAKYKLQYQGQNEFYINCHIQDIPENGSDWAHLGAIHSSAMLPTDMFSGMMHHTWTNISWSTKSGIFQTETPDSSFSDQEKKEKHIAQITLQHTLVLFNKFPILQLKVQARQLGPGCVEIHLQSGFGPMFIVQTVTPVQPLIHRVTHSMYAPRYMSPYSKIVLIGESIMFERDVLVWNHKKYMHKPILLSEEKTIKAYRRWYQQFYSENSPTYESCKTSLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUY0</accession>
    <name>A0A232EUY0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002077">
        <property type="protein sequence ID" value="OXU22146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUY0"/>
    <dbReference type="STRING" id="543379.A0A232EUY0"/>
    <dbReference type="OrthoDB" id="7684415at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28499" checksum="EB49FDCC124F5EE2" modified="2017-10-25" version="1">MAEGKEEPTDGGLLMDGWKNSSANTKNVVSMIRLESFNFSSKQETAQNLIDVFQQSIVLTRYRFNVNLHGVVTDNASNIMSMGRMCELWHTTCNSHSGNLLCKAMVDVSFAKQVNTLLKEFKNPNLEHLLVEAGENRIILAGDTRWCSYRDVFRRALRNAPFMWLVVNNGAIIKDDNRNLLFDDNFELRLQESLVMLDPVCKLIRNCEKNTATITDSTEYWLQINLPAINNDFEVLIENRLVKIINKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWS7</accession>
    <name>A0A232EWS7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="9">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_004608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01001823">
        <property type="protein sequence ID" value="OXU22804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWS7"/>
    <dbReference type="STRING" id="543379.A0A232EWS7"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU22804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="19264" checksum="0DC37491FFFC7EFB" modified="2017-10-25" version="1">METMADGKPCRTCTDFKTWAKLQKQTFDSEKKSDQAKQGSDHKYTETMNARRKDCPLDRDELGSRTWGFLHTMAAYYPESPTVEQRKDMKTFFHLISKFYPCNVCAEDLQEQLKKSPPKTDSQHQLSQWLCDVHNEVNKKLGKPVFDCSLINQRWRDGWLDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWZ8</accession>
    <name>A0A232EWZ8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001803">
        <property type="protein sequence ID" value="OXU22879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWZ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7659" checksum="0D6EC7359D5DE6AA" modified="2017-10-25" version="1">MLETKIVGFCKGPFCDLRFDLESVFKLLRSRILTGKIEVNLGMTLKNDRFPIEDHCFEPISNYYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX64</accession>
    <name>A0A232EX64_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_016170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001792">
        <property type="protein sequence ID" value="OXU22910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EX64"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055444">
        <property type="entry name" value="ARM_ECM29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23702">
        <property type="entry name" value="ARM_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="ECM29 ARM-like repeats" evidence="7">
        <location>
            <begin position="595"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="8">
        <location>
            <begin position="1257"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1633"/>
            <end position="1652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1813" mass="202893" checksum="9E3BB9A581C31FAB" modified="2017-10-25" version="1">MVDQPMDEKILLERVFLRLGSAETDEQLQASICKFLPPVLLKLSSSQEGVRKKVMELLIHINRRIKSRPQVQLPVEALLLQYQDPAASSFVINFTIIYIKLGYPRMEISKQAELIPSVLNAIQGKPLSHQDSLMLIIMPALAHVNIPLDPEKRASLLGLQDEPQVAKQLLNFMLDMLLLPYGSIGQSENQQPGQPIDWSQYPVPPGLSEYAFKRVIGETPPTAEQLEQTKLGIVKFLAGGFFSDSDILIHLIVAAADTRFSVANLADLELKKIANLLDWSSMQLAAPLYTLFLGTDALATQKEVKQEIKRTPASIRIRLKLLHYLCRVTKAGFIIPPCIQVIFESLYGANNTNSKLKSLALQFTSNLVQQCSLTPIVRVAKVIQNGMMKLITEEAEPAHRLMAYTIIGQLGQRIPSLVNKDLSLLQNFFDMLASTDGDLRRTVRDALISMTSAFVLNKDDDTGISLMVGLLSAHIESLEAHVRFVAVHYSATVFPPDHAPSRYLLLLASGDSKLEVQSEALKSLYGTSYKNERSKCLAKEVALPDFPQLMSYIHSKVQVRVNSNNKVTVGNKILPFNTATFVEIISYLRLCLARSANVVIQNDSIEHPSEFTPLIGRYLEKLYKENPDSLYHYVDIVVLFGQVTGDEVALSALLEIVGTIPTYIVERYAKEQSWIQSLLTSSKEYVRDLAAKIYAVFLAYVPTNEFENQISKMLKTTKDKVLENQQGAILALSYSMERKLILRRSEDKNTLVNWNTYIDTVKAICDFLNVNNPMLLTAAINGIGEIGKSFSLPLPSEAEKNTSKKSVADKLFSIFINTKSNAKVKEKVALSLGYICVGEEFPHTKMIVEKFIETANETKDINIHLSVGEALVCCVQGPASPEARDAWKTLPSEHSVPYTKESNDLLVFVLDKLLSIASKPHPNIRQAVCTWLLTILKHNSKRQGIIEKLSDIQSAFMDFLSENSDIVQDIASKGLYLVYTSCSEDKKAALVSAITNQLLHGRREVRKVTDDTQLFEEGALGKCPTGGNMTTYKEICSLATDLNKPELTYRFLHLANHNALWTSKKGAALGFSQLASLINEDLSAQLPNIIPKLYRYQFDPIPKTQQSFASIWRSIVPSTSKALEQHHKEILDDITQNLTNNQFRVRISCCLALADLLKSPNVSINYVECAPGLWKQLFRVMDDIHEGTRQEATNTTKVFSRVCIRQCDASHGKTGEELLQVILPVLLEEGITHTVSQIRMISLQTVSQLVTTAGSLLKPSIPFLIPALLNSIGEVENANLLYLRNMTANSAEVQEAIDNATAQQTKTHTTTDTMTKCIQYIDAPILKELMPKVIDLIKSSLKLGTKLACSNFLIKLSSHMKHELQPYAGKILAALINGLTDRNAGIKKNNAVTIGHIVGCAKESSLDKLFNMLNTWYMEREDDSIRLAIGQTLQSINNHNQDILKKYSNIVMPLTFFAMHAEKVVGENEKTVELWTELWSEITPGTEAGIRQNLTVITSTLNTALESASWTTKAQAANAVSTVATKLGATIDEEARNSLLNILVNGLQGRTWNGKTRLLNALSTLACNSKDALKNDAKLKETIVEALYKESKKEGLEYRRHAFKALTEVLHELDEDKYKQVYDIAQEVLPKLTKKGDDDDDDSMEENKKKREEKIKLQETIYEGLGKAWPTCKETQDQYCVQFVAHCFDTLPTSTRPVQVSILTTLNRYVDKLALLKMDYNQCTENDKKMLDTICGTLLKILRYAIGIAKYTRIRKEALNIVISLSRKLSEMQNHKQSNFMMALMKDMLPELSKDNQPEIRSRVVDIKDMLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXX6</accession>
    <name>A0A232EXX6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001677">
        <property type="protein sequence ID" value="OXU23251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXX6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="17467" checksum="ADD419C34874111F" modified="2017-10-25" version="1">MLYILFSTTTAVAAATATAVPVFSPLRLICTKRRAASAIGYRSTRAIIMQTTLFIDDRRSRSKFQRRRSIAYRYTHIFIYRVDLSLLFYTEALPDLSRSDCVIALDVADTLLSVCVCVCVCSCGYRQERRDNRALFARDERVTRRVQRFACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ75</accession>
    <name>A0A232EZ75_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001515">
        <property type="protein sequence ID" value="OXU23732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ75"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="8824" checksum="1EE976568063B212" modified="2017-10-25" version="1">MGSLPVLDCGPLLASSPGIIDHEATEVAGKPAFALLSTVLSALQKNDVASTRVLRQRRLDRVQSNNTIAANSATRQCVLPSIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZI6</accession>
    <name>A0A232EZI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001532">
        <property type="protein sequence ID" value="OXU23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZI6"/>
    <dbReference type="STRING" id="543379.A0A232EZI6"/>
    <dbReference type="OrthoDB" id="2347980at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061138">
        <property type="term" value="P:morphogenesis of a branching epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18489">
        <property type="entry name" value="BACK_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18283">
        <property type="entry name" value="BTB1_POZ_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18284">
        <property type="entry name" value="BTB2_POZ_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042345">
        <property type="entry name" value="Btbd7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047936">
        <property type="entry name" value="BTBD7_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047934">
        <property type="entry name" value="BTBD7_BTB_POZ_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047935">
        <property type="entry name" value="BTBD7_BTB_POZ_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064:SF3">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="207"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="311"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="883" mass="98371" checksum="C89F7B14BC7CE34A" modified="2017-10-25" version="1" fragment="single">MNVFRALIPCALQRSGESGAGGEGDSSSGGCWFTGRGQGDDSRMTHRMGASASSSLAPVGGDSVQAARLSASGNPDPLSIILCHRKYYCLTSSDNFLTKPDIANFTLNKQSKPTMFIFRERKKRVTGFATLRKKFIRRRRSSKACDHGRIIRELVSSWSPLEASALLEEYEALAALKDLHVQAELARPPAATFKQDLSTLYDYKYCTDVDLVYRGACFPVHRALLSARCPYFRDLLAGCPGYGARICLELRSHNIEVSMFSGLLRYLYTGDVCPHDGSLDAGLLRRLGEEFGNPNPLEHDLRYLLDTGNYADAALVFTSDSDYQRPDSGSSEYGFRPKLELPCHKAILSARSPFFRNLIQRRTRSGEDHTERALHIPTRIVLDESVIPKRYAHVLLHAVYLDTVDLSLILRGSGCGNSAGSLSEALTHTGRVRPSPLEEAMELYQIGRFLELDILSQGCEDLILEWLTLDSLPTVLKWGSQPHGSAWVHRQALHYLREEFQPVASSPILHQLDHAHLSNVLQSHFLQASELEVLQAVLKWGEQELVRRMEDREPNLLSHTVHSVARKGVKKRDLSDIELREILSELLPLVRMDHVLPPNNEILAQAIRRGLVSTPPSHMIGDERENLRINAWIRGGKKNGLFVRPRLFMPYYEEIKALVEEQMVQEAELVRLRRARYIHDIPDTLYMVDEKPRVMGAAGVDILAAALPDSATMSAMLKREQKLRQSPSCQRAISLPLSSRHEINRQLRLRVVREFNLPDAVADLLENAACYSLGEPDANSVSADEDCGSMMGLGGNSGLGASAAICYGRNMTFPRHAASYAHRHHELPAIVTEGENYRLSAEHLESNSCSDGHLSGIMPDVAMATASFGALQLVEQQELELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZS2</accession>
    <name>A0A232EZS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001477">
        <property type="protein sequence ID" value="OXU23829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZS2"/>
    <dbReference type="STRING" id="543379.A0A232EZS2"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF161">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="131" mass="15340" checksum="9BE00B7FE8EE23D6" modified="2017-10-25" version="1">MEESATSMIAAPAEDWRDESLAVWEVIVLALILTTTLMGNVLVLFAIYLKRCRGRRQRLTRMHFFVMHLSVADLITGLFNVLPQLAWDVTFSWSSNTTKLHLTYRRLRLELEKAIFCFYDHLKWTLLYQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0C0</accession>
    <name>A0A232F0C0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001369">
        <property type="protein sequence ID" value="OXU24216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0C0"/>
    <dbReference type="OrthoDB" id="7675441at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="608" mass="71886" checksum="90B4486721423DC6" modified="2017-10-25" version="1" fragment="single">IVGKTPQDDGILRLPTKHLIQLTKKPPFRPHKFLERQYQLQAQKRHEEHVRQDYYRETARYFEREAAAAQKFNSWSTKSRECYSDRLEKLQRAENLKKRREKLRRLFAEENEKFEKELEEQRLTRRRSNEAITLEELRQKLMEKKAEQSLYYPNACRLRSYAFSPTYAARKLEALDNANNGPDSVRPVSGNSQRHKRFSTSPSIGRALYYDYEEDINNNEDNKSSTPTNRRYAESYRTAKMSEHDKMAEHVPRTNLRFAARSNQQSMCETNLRDDDYPRECHNITHTPQENNGQYLFPSEQEEQRQQNKSNQTNEAQQEYRDDDSSEAQEDRSVEERLDELNMDGRSNASSEYEQSLPEERREEIDEPDHAQVNAAPLHADFTAPTAFVRHTENEKTDDHNAAEDMDRHRRGNMRQKDADVAGDADISVQMYRYLKHNDLKRQIVDLCKREHTFVIKQSFDDALRLREMRNELILLKNKNLYENQDLAIDEETRKAGLEVIAAREKLNEKRTKMRNTGLYSDEAKDLWKQWVHEDEAIAKTETNAMRDLMLQELENEWQNLALSDKNRISQLYDRVMIGSDLQDEQKLAAVIRAANEGQKQYMNYLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0E5</accession>
    <name>A0A232F0E5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase subunit gamma-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001391">
        <property type="protein sequence ID" value="OXU24144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0E5"/>
    <dbReference type="STRING" id="543379.A0A232F0E5"/>
    <dbReference type="OrthoDB" id="5394539at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="51272" checksum="F5D1F0D2E88CD4F1" modified="2017-10-25" version="1">MGYLSRCHSKGSFIFKTFLKHKRSATSLAHSQGSISKETVDKEFTTDIKIDIKTISKLEKISLVDFDNDGGIQRLEAAIRFAQKLREVQLHPSVKPMYSVLENERLHLREDKVTEHTMEKIFKTLGPTLLTLKEFGFAYGVQGILMRRNLEKLWLMKNMTQSDYNVFLVDSDQITANLKDLSDIGLNNPPFGIAEISSVKNTWNESYFPPKSKPIKHRIAKVTTIYEGDGDIISVKDLFYKKQRERKSWWRRITENPNIFHIGEIKQERGKEYVEIEARLPFGNIVVETIYYKPSAKLYLRGGEFSNNLKIVENITSLDWGCLALICDGYVEIDDCKEMQVHPNLAPYKAYSKANIKPEDNEQTRIALNNLSIHLIQLLREQGIEAVLMNLAKQPEVFQVPYILTVDNESLKNGFIRVVSQRTLCGEIVHITKLAQHVYDLTTIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0Q4</accession>
    <name>A0A232F0Q4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_001474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01001361">
        <property type="protein sequence ID" value="OXU24241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0Q4"/>
    <dbReference type="STRING" id="543379.A0A232F0Q4"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="55"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="581" mass="65695" checksum="85887DEFEC36FBE7" modified="2017-10-25" version="1" fragment="single">HTYQTNSFRFLRPPRTRKTLGSRVFEIPIFLTGRYDVKYSQLKSRHPQKRMMDLLIETSCGKIRGVVEKSSEGFDIYSFKGIPYAEPPIGELRFKDPVPIKKWTGIRDATKFSPISMQYDSTIRIKSENEDCLSLNVYVKAGTKPNARKAVMVWIHGGAFIFGSSYHTIYGPDYLVRHDIVLVSVNYRLGVLGFLNLEDEYATGNQGLKDQALALRWVHENIGNFGGDPGNVTIFGESAGGVSVHYLCLSPLSKDYVHKAISQSGVIFNPWTEIKNPKKIACDLCKVLGKPLTNSKDIVEFLRTIDTKRLLEAQQEMIKHADELIFGPSSDPKSANPFMSESIEKEANKGVHIPYLVGNTSREGIFFVQEEFSLSEVKNDEAFKMMGQDVNVAFPFNTTKVLNKYQVTLQQAKRLYYKSKQISVDTIESFVDSMSDLLLLDGIHQFVKVQVEESTSPTYFYQLSYDSESSLVKFGKAAQISGVSHFDDLRYLFKGKIYDEANIGLKKGTKDYRVMEQMTTLWTNFAKYGKPTIATSKLIPVNWKPVTDKTVLRYLDIDEDLTMQSVLNLSLKLSSAQSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F125</accession>
    <name>A0A232F125_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001352">
        <property type="protein sequence ID" value="OXU24269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F125"/>
    <dbReference type="STRING" id="543379.A0A232F125"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="10">
        <location>
            <begin position="102"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="325"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="522" mass="59817" checksum="EA8C153BE74DBA96" modified="2017-10-25" version="1" fragment="single">YTSKIKRAVDVIANIRAFSNNSASQTYRTSVVALMQALIGALKEPAGRRVLGYRCGNVGGRKSFSSVTMSDPDPCKIEMHFTRPTSDTIQTKPFPIRGERANFVNKPHVIAMVGLPARGKTYISKKLCRYLNWIGINTKVYNLGEYRRHATTAYQCHDFFRPDNIKAMAIRTQCAMDALNDVCQWLESGDGEVAVFDATNSTVERRQLIRDIVVKKMGFNLFFVESVCNDPEIVEQNIMEVKVSSPDYTNMNKEEVLADFMLRIEHYQEKYQPLDEQYESDLSFMKIYNTGEKVLVHKHEGHIQSRIVYYLMNIHIVPRTIYLTRHGESAMNLDGRIGGDSDLSDRGWEYAKALGNYITEQDIQGLRVWTSWLKRTIQTAAHVKAPQERWKALNEIDAGICEEMTYEEIESKYPTDFAARDQNKFSYRYPRGESYEDLVARLEPVIMELERQGNVLVVSHQAVLRCLLAYFLDKNADELPYLQVPLHTIIKLTPVAYGCKVENIRLPIDAVDTHRPKPKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1G9</accession>
    <name>A0A232F1G9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001237">
        <property type="protein sequence ID" value="OXU24646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1G9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="231" mass="26128" checksum="C7E25474C1A7B18A" modified="2017-10-25" version="1">MLQTIPTPQVQEDEQPLNRSVMLIPGDIGEVTIGSISDEIIVESEVTEGRLDKLLNPQNNTYYNETSDSKIRNKNSSIQPSAQFSTDVKSISNCNEAIKHNQPPSSKSNLALKVNTAGKAQKRRRSEVDEDSELEELLEDENITLQDISTVLNEVRTLVVETRAMREKEDILSFNELCRQHNLNLPLEELNEFLDFDNQIQSKGDLYKSLKKYFISNIATCDTVKAQVTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1K7</accession>
    <name>A0A232F1K7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_007376</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01001341">
        <property type="protein sequence ID" value="OXU24308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1K7"/>
    <dbReference type="STRING" id="543379.A0A232F1K7"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="410"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="858" mass="96835" checksum="890EDBFB5FB1FEC0" modified="2017-10-25" version="1">MKENKKKPAQSSRIFIIIWGFVMHIIFLWGVMDANFHSPIIQGLPVVPMPSGSPAKRIFVFVADGLRYRTFKSFTPPYLNSIIKKGGVWGISHTRMPTESRPGNIAIVAGLYEDPSALFKGWKENPVDFDSVFNQSRASWLWGSPDIIPIFTKGNNHNIRGASYPASWQDFSNEPAATKRLDDWVFHEYSKWLANEAPAYKTEDKIIFYFHLLGCDTAGHAAKPQSKQYVDTMIQLDRNIKKVVENTENYFGKDTTAYIFTSDHGMTDWGSHGSGSTDETETPFVAWGAGIAKDSNTIDIKQADITPLISALVGIPVPVNNEVGVLHHELLDPKNDEFIANALLTNAKQLAEQIKANRELTTGRSIVNQFYKDKEYHEKLARAERILDKGATEKSITELEYVTKLSEEVLTYYRRYQTDRFLFCLMLMWVGWIALLFVDLSGLPRRTIQLGCYSWMLLANIALGVASIPLFIEYAVAGCKEWRLFGYGMICVISLWLAFRGIIKKGPTLEIDSNKPFIEALGIVFLTFMMFVGLIYRWTFSISMLVAVGLQKLIFDRNAPSWLLITGAALVVFPLLPVVGPQPRVYIVLIALGVSIVPIIKKRRIHNYNKVIEVIRIILTSLLCLNVIDGRAWLSWLLLLSTPLVISLYPKDWNQRIFGVTVALLSPLALLSASYEPIFFLIFATHIQHWPTFEFSQKSESGLRVLRLRNFSTAAFLMLYTLLCFFGTGNMASLSSFDPSWTRHFLTVFSPFTMASLILLKFVIPLILVGCLIRALAPDSTIFSAVLLLGDCLAIPLMYGVTNQGSWLDIGSAISRFAIAIVLPCLLLLVFYLTQPFTTFSLQDFLRRRAIKNQRLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F237</accession>
    <name>A0A232F237_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="22">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSAR_005271</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">Alberta</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="22"/>
    <dbReference type="EMBL" id="NNAY01001266">
        <property type="protein sequence ID" value="OXU24559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F237"/>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05032">
        <property type="entry name" value="PTKc_InsR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000528">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001941">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000026">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 22" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="939"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="828"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="999"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="721"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1336"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1436"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1340"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1447"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1460"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1493"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1033"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OXU24559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1584" mass="179007" checksum="BA45446B9A37A1CD" modified="2017-10-25" version="1">MSYPDLVEITGYFMVYRVQGLQSLGHLFPNLAVIRGHLLFLNYAFVAFEMTSLQEIGLASLTDIMRGSVRFEKNPVLCYANTVDWDLIAHAGKGGNVISYNRPKNECPVCEKDCPRRQTNLDERLCWNKQFCQKVCTSCQDKDERDRTCTVGSRPDNKTICCHENCLGGCTGPSNLECKVCRDVVVNQNECVSSCPNGTYQFFNRRCITKRECQMMRRPREAPPETRAYPFKPFNNECLMDCPAGYEEVAEKDMWSCKKCTGPCLRECSGIVVDSIATAQKLRGCSHIKGNLEIAVREGQNIVHELEESLSNIEVITGYLKIFRSFPLISLSFLKNLVEIKGETLDMKDYSLVVLDNQNLQQLWNWTTRPPLKIGSSNPVPKVSFHYNPKLCLQTIEELRERTGLNPFREVEVSPTSNGDKVACNVTEIKTMVFSISSKAAMINWEPFEHHDMRTLLGYVLYSKEAPFQNVSMYESRDACGGDGWKVVDIGVNEEDKIKMKKIDTSISDSNTNNVTNNRSSTYTQYTILTQLKPFTQYVYYVKTYTISTERSGAQSKLTYFKTLPGQPSIVRALTIYSNASDTLVISWLPPTEANSNLTHYEITGQMERYDLTFLRQRNYCIEPMQVLEYKPIAEIAAEEKKRAEQELEASKIPEPSACECKKRDPVQSESEVYSSITFEDALHNTVYVRRQDNRRRRDVSYTSVMLEAVRMKRELTNYQEKDVISHSKKSLQNQSKTNPGQERSLEQQKILKPDEDYIEDGAIVYFKRKVPANELNFVMRGLRHYGKYNIKVTACRDKEANAHELPCSSESMKSLQTLRLDHADEIPSGTLRLQKQANNDSTTSIKLTWDEPPRPNGVIVTYQIEYKRVDVQNLKAEVACTTRDKFNEDGNSYLLQNLATGNYSVRVRATSFAGNGEYTEYKYFDVPESNYSMPAWKVILIVLFSISFILGAFLVAAWFFKRKFMRNVPSMRLIATVNPEYVSTVYIPDEWEVPRKKVHLLKELGNGSFGMVYEGIAKDVVKGKPEMRCAVKTVNENATDRERVEFLNEASVMKGFNTHHVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRPDVCENFSRQPPTLNRIMRMALEIADGMAYLAAKKFVHRDLAARNCMVSDDLTVKIGDFGMTRDVYETDYYRKGTKGLLPVRWMAPESLKDGVFTSFSDVWSYGVVLWEMVTLASQPYQGLSNDQVLRYVIDGGVMERPENCPDILYGMMRQTWCHKATRRPTFIDIERELMLEVDTTEFEKVSFYHSPDGVEVRNQNPPSQYRTDKLVAFNPKNAELEFLDSKMKTLCFSSLNRELEMVMQESREEEAEGEEDSPLRQDFGDFSSFEPMTRRKNGSSGHFGMEPFTDNSKSPTSLALGFLDLNSSKAPLKAGFDDFDGVSVGSLASSKDTLNLPFVEDSVKPAKNSPFAQKKSSSKGNVSQSSAGKSSLSPQSPSIIATTGNLGSKPSPSLVSSTRSDPEYENRSPEAVDQPQQQPPTRDVASLRVSFPSMDAIDSDGTVLPETTSSIVVDSNSSSATLPSAKQQYVNKSGEQQVAPLNNGYIGGPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F291</accession>
    <name>A0A232F291_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016594</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001188">
        <property type="protein sequence ID" value="OXU24815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F291"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000401">
        <property type="entry name" value="serine/threonine-protein kinase haspin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1224"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="68"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="500"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="658"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="735"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1108"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU24815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1540" mass="176301" checksum="11B9D6474BF29DA4" modified="2017-10-25" version="1">MERQTIKTYSRKAPITEYKPSSALVPSFPNPVEHPHVRESRLNDKTLVVDVFEDTFDRIATGVVVKSPKKYASPHSSDTNDSDNSSDDYFKRPTRAEEETERKRVSDEFWEQENQQFEKDSAKTRQRNKKGATSKKAGVKRKKLVSKSSDEEDDFTANKQSAKVTKFKEPKQQIRKVVKRNKKDSPAKGKVPEINFPGENKNLANAEDGQLNSSVMVNDCSLGFIDENVQMSKDICNVNQKKFLHDFPTSTPRDHKQKLIVNVQNLSPITLNKEHLSVADTESISKEKHVLRESNLNDVSSQMTSLSKESNKVVESKSVQIEKNCPSNSYIHTPSKLISDRKERSETEDEDHVVEENNDENNSNMCALLPANANVDSHRNLEENDKLQVTNGKTQFFNRTPTRRNQRNDIPSFVESPLLFDDTEQSQHIKDRSVASSNISNITGESNDKSLKNTHTSKKSSSAFKNLYGELENTQREHFNESSYSPHEWSNDYDSSYGDFTNKNKTMVNRTEDPERRNLENSHEDKQIDTNNTSMDKELSKESILNASESSQQQSSGNGELQKIEDVASLVNTLDPKNESINSIITNRSIDDQRKISETDNVISQDIEHSVEAIHEIDSNSNSFELHIESNTSSTKSDSPISENQEPITNQCSKMDNADEHVGQNSMNHEHQINECSRPTMSSSTNEREESIQNNEDDERLNGQKLIIRLTKLSPDFYKSSPVFLSKTSIRKQLQMQTKNVKKSRVSKKGTKKTVSDNENSDVEKLDENRESRLFVLSGRVTKSKTNKKALKKSTRTSRKKKESYKSYAMDIVENEILHHNKTGSEGNEDKYKKLCQLFNIKELCVLLSKLPDLDMENKLSVSRRKIKSTSPIIKRKSSRKSKSIYKLGDEDKSGNESINKTVEDSTINVDAERNNSIKINKYIDGIDQKTLTVNEQSNPENRNEINASFNGEELCDILSKLSDPVKITMRRNPYKRLDRPLAAITEHLVEQPSRIDEEEEEEEENRNKEEINIETRKTDKNLVTNSSIEESDTNKLADDQTHPIFLKPGKSWARSLSIINHFHTGQNLDQLAVGRGKSWRHSVQTILNMQSEANAQAVARNCSEDKDEHSQSFNMPLVPPRESNRVSTIVTSPSRFSRFSIRIIPDGKRSTLTDDFTHSRGSSNISDRTRKTSLSRKTSLKIRRETLIETEEDLIRSAKDIILKRCKQKSYLQFSDCFPDSYIENCRKIGEGVYGEVFLYQNKTEKSVIKIIPIEGDELVNCERQKKFHEILSEIIISEELHKLRFGSDFNTNGFVGVNRIMCVIGKYPEKLIDLWNAYDQEKNSENDCPTMFYDDQLYIILELAHGGQDLEAYVFQNASESYSIFLQTAFTLAVAEQALEFEHRDLHWGNILISKSDDNESTYKLGSEEISLPTKGVKVSVIDFTLSRMSYQGCKIFNDLAADPTLFTAQGEYQFDIYRMMRDNVNNDWQQFNPYTNVLWLDYTLDKMITAARYKRKTSKIHKSAIEEMKMLRKEVLNYKSAFEFVSKCEIITNATKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2D4</accession>
    <name>A0A232F2D4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001236">
        <property type="protein sequence ID" value="OXU24650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2D4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="118" mass="13275" checksum="2AE5FC3ECD3893E7" modified="2017-10-25" version="1" fragment="single">LKLVGSLVSNNHFEHEEFQLIWRPKPRVYYFWACSSSLRFTSPLQVCLIVISSDTSAALIARPRSSACRENPILMGVTHVFALKHIPSSVPGDCVLTHGRLFLHLLTSTNKLIQQMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2J0</accession>
    <name>A0A232F2J0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001190">
        <property type="protein sequence ID" value="OXU24802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2J0"/>
    <dbReference type="STRING" id="543379.A0A232F2J0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="311" mass="35101" checksum="FD8595AF5094C70B" modified="2017-10-25" version="1">MLRQMRILRISGKGEDWISFSDLFTSLVHSGSGISDVTKLQYHVMLNWCGYRADQGRDDNQTRTMRALGRHFSIVIKLWEAELSEKDQEFVPEEDEPERDINSTFWDLLKFLERRAQALKMLNSECKVDKRLASTSTSGPQGPAEEIDMDESVKTLGVHWNPAQDQFRFSVSDITKRSILFNNARLFDPLRRKGAQEPLLGFLTLSELAEARSVVIRLSQASSFAVEIEALKAGGVLPKGNRLSKLNPFIGKDNTLRVGGRLSHFSLFFDCKHPPILSQESALSHLFVYSAHQLCLHGGFTLTSSVLMQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F331</accession>
    <name>A0A232F331_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrator complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001170">
        <property type="protein sequence ID" value="OXU24898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F331"/>
    <dbReference type="STRING" id="543379.A0A232F331"/>
    <dbReference type="OrthoDB" id="1921953at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033060">
        <property type="entry name" value="INTS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054519">
        <property type="entry name" value="INTS7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056517">
        <property type="entry name" value="INTS7_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056516">
        <property type="entry name" value="INTS7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322">
        <property type="entry name" value="C1ORF73 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22965">
        <property type="entry name" value="INTS7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24437">
        <property type="entry name" value="INTS7_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24436">
        <property type="entry name" value="INTS7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 7 N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 7 helical bundle" evidence="9">
        <location>
            <begin position="534"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 7 C-terminal" evidence="7">
        <location>
            <begin position="807"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="956" mass="105557" checksum="FA702742AAA99B5B" modified="2017-10-25" version="1">MINVRMNAFNDSTIGEPEQDANSALIELDKGLRSTKIGEQCEAIVRFPRLFEKYPFPILINSSLLKLADVFRVGSNFLRVWVLRVCQQSEKHLDKILNIDEFVRRIYSVMHSNDPVAKALTLRTLGSVARIIAERKQVHHSIRRSLDCHDLVQVEAAIYAAQMFAAQSKLFAIFMCSKISDMIRGQATPASMKLQLIPILQYMHHDISTASMANELCMELLESYPADEFVRVTLSASTTLASATLINVPAQVTLLLRYLLEDPRSSIKTHALQLLHNLAKKGAHLWPQGALEQLIDSTTSLLQDSAGNKNLLIRSLNVIEVLSESPVTCDANMEEGSPLIVLCSKACYSPNPIVAVKAITIWARIACYCYEEGLPVYCIQDVVSCLESLIMLLTLDDKYIYQLKVCLQLAVKLCQVQRGHCNIFVDAIGSTLINTSAKSKHSDNQAVALCEALGAIGSLGDNILLPLLPDILVKLKETPHAHTKVMLCTLLFQMVASGYEWNPECLEAIDSVTKSIDDWNKYRIARGATRYGHHKIATRLFKDLKEAVASEQLHFWLLGLELLTSAENCLLDDSADNITVKKLNGAIAQYASACASFKAASTPLRSLQFACDYSKLRCEFLQTLVQLLHSCRSLCTAPPYAIAAHEAHTAKDELQRYGRVTSQLRKSLLELRTCAENYQKLYQSAFDADPGSLNNIRALQELCLLLAHSVQRVCGGPPVSTNFPSTDASFHFGETVEMQQLAKCCSQIQELAPEGDADNETSSRMTSGISHLRVASLVSQVTLLASSKLRLPVPRYFFQTLQTTSVKLSVWPQPRVLGEPVSVPQGSQLSLKVEGVLRHGKRASLFRSVAAISINISTAPPSKNNSDRKDNNISDLEQTVVPHRDFFSCEFLLSLGAQNNNPCMGNVGNTGAGTGGQYQVTASANIVDESGNVWRCGPRSVLQVRVHEEPSRKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3A2</accession>
    <name>A0A232F3A2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_006905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001168">
        <property type="protein sequence ID" value="OXU24907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3A2"/>
    <dbReference type="STRING" id="543379.A0A232F3A2"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001325">
        <property type="entry name" value="zinc finger protein 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="293" mass="34342" checksum="A75D827FFC76B8AA" modified="2017-10-25" version="1">MPRCLLKSMMRYGQNNRSDDDLKSPVQRAPAVKETKKKKRRYKEGQGNLDNIWSWSNLPIVTRYNFHQKNESVLWNPESAKNVECFVNNTGNHSNVDQAQENSSASCSDDQAVTYHEQADDKAMEMARLLQLQENHSTVNVRVEEKSTDVFLYSSNAQMQNVVSVIYSPANNKENETVKSGEEDRGCSEIEGTPNQKRNKTMHFCQYCHKSFDRPWVLKGHLRLHTGERPFECPVCNKSFADRSNLRAHQRTRNHHQWQWRCQICLKAFSQRRYLERHCPEACRKYRISQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4F6</accession>
    <name>A0A232F4F6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000977">
        <property type="protein sequence ID" value="OXU25651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4F6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11287" checksum="EA44D034B5CAA042" modified="2017-10-25" version="1">MIEERLLKSKSVADRALCWCFSYLSDRLHAVVDEGSDLPNMLKLLKRMIFVDDTQIYCHCSPGGLEQALSKVQAEAQAISDWAAINGLSLNLAKCKVMILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5E8</accession>
    <name>A0A232F5E8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSAR_007020</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Alberta</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="NNAY01000937">
        <property type="protein sequence ID" value="OXU25832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F5E8"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000097">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031733">
        <property type="entry name" value="Dynein_attach_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15867">
        <property type="entry name" value="Dynein_attach_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1139"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1165"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1217"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1243"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1272"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1305"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein attachment factor N-terminal" evidence="22">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="21">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="318"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="417"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="24">
        <location>
            <begin position="1105"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="861"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="890"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="970"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="971"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="972"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1052"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1058"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1078"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1081"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1082"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1082"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF15867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OXU25832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1339" mass="152430" checksum="77ACDDBFA9399A8D" modified="2017-10-25" version="1">MSNLKKPIDFKMLENELDRALRADELYKLQNDAKLRAIEQRVPSYDHFRGMVQAAHLRPLERSEMQKKADVSWNHCYNKSGDEEILKICGPTNDGRCDNVFESTEPQNSAEFLKNWKNLSDHRHKLEYLLRFRKGLREKFFKAEVPSEFLEEFFKLSLDVCSPDVFLEVVEILRIFTECNRFALSLAMISESGKNCLQLLFENFAAFARNSAETETVERLMSKYCMRGATMRLEEMPLRLNSDERDFEMDEETDYLLQPPEDSIRMMAGNRNRHRRLSKCSTFFKHVLCGCCTWMWRRCCKEKELRARTIQIGQPMYEKFPTNVIRNQKYSIITFLPMVLFQQFKFFLNLYFLLMAISQFIPDIRIGYLYTYWGPLCFVLAVTLCREAVDDFRRYKRDKEVNGQKYHRLVKGFSAPEKVPSSKLRVGDLVIVEKGQRVPADLVLLRTTEKSGACFVRTDQLDGETDWKLRLAVPTTQKLDSDAQLFDIKASLYVEKPQKDIHSFIGTFTRYDGYSSEESLGVDNTLWANTAIASGSALGVVVYTGQETRSLMNHSAPRSKVGLLDEEINQLTKVLFCAVIGLALVMMCLKGFSGPWYRYMFRFVLLFSYIIPISLRVNLDMGKTFYAWCIQRDKDIAGTVVRTTTIPEELGRISYLLSDKTGTLTQNKMVFKKLHLGTISYGQDSFDDVSSVLSTFYTVDSESSPVKVVVTGTHSGKVRRSENTRVYEAVHALALCHNVTPVYDEVNNKDVASKLTDTDSIETVETSSVQSQPEAEQSYCPPEQGLTYQASSPDEVALVKWTEEVGLALVKRDLNTMQLKAPNGKLLNYTILQIFPFTSETKRMGVIVKDETTNEITFYLKGADVVMAGIVQYNDWLEEECGNMAREGFRTLVVAKKNLTEEQYLDFEARFNAARMCVTDRVSRVAAVIESLEREMELLCVTGVEDKLQDKVRSTLESLRNAGIKIWMLTGDKLETATCIAKSSRLVSRTQGLHVFKSVVTRTDAHLELNIFRKKQDCALVISGDSLEVCLQYYEDEFLELACGSPAVVCCRCSPTQKAEVVSLIQRHTGKRTAAVGDGGNDVSMIQSADAGIGIEGLEGRQASLAADFSIQQFSHLANLLLVHGRRSYKRSAALSQFVIHRGLIISTMQAVFSAVFYFSSVPLYQGFLMVGYATIYTMFPVFSLVLDKDVSGKIALTFPELYKDLSKGRSLSYKTFFMWVLISIYQGGVIMYGALIMFEDEFIHIVAISFSALVLTELIMVALTIRTWHHIMVLAEVFSLALYMLSLVVLKDYFDAEFIKTVDFLWKVVVITLISCLPLYILKLLRKKFSPPSYTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5H6</accession>
    <name>A0A232F5H6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000885">
        <property type="protein sequence ID" value="OXU26064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5H6"/>
    <dbReference type="STRING" id="543379.A0A232F5H6"/>
    <dbReference type="OrthoDB" id="7789829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="159" mass="17059" checksum="90F68A8B085BDE8B" modified="2017-10-25" version="1">MLSVPHGKLVYGAPALGYQQPIAAYANVGYGNAGYGNAVYGGYPAVYGGHGHYAGEYDHHDDDGHHGDHHAYPKYAYNYGVNDPHTGDVKSAYEERDGDVVKGSYSVNEPDGTIRVVEYTADDHNGFNAVVKKIGHAVHPAPIHAAAPVAHGYHGYDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5W8</accession>
    <name>A0A232F5W8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_009730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000925">
        <property type="protein sequence ID" value="OXU25873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5W8"/>
    <dbReference type="STRING" id="543379.A0A232F5W8"/>
    <dbReference type="OrthoDB" id="7523059at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="208"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="436" mass="50158" checksum="D3DFE2C122B68022" modified="2017-10-25" version="1">MKPEIALALIMKRWRDWQEVARYQLPAQQEAERQNLLELFVLYQKMKKKKSQATQVQFAIEQPISQVEAQEEKIRKGNDALVVYSQPVDYEKYFEYIRMDVETYNELFKLVEPKIKKQFLIKYPIPAHTRLQICLRYLASGDSMTSISSAFKVANNTVSKIVTDTCQAIWDVLSNLVFPTPSVDLWKERAHSFETQWDFTHCIGAIDSRQLVLQTPVNTESNYCKTNETIVLCAIIDANSCFSLINIDVEEVLEDGINFAASETGCHLQDNTYDIPAPSKINETGPELPYVLAGNENFPLTVNLLRPYAATSDLDLPKQVFNYRIGRARKCSDCAFRILTNQWRIFHKKFSNSASNTIKITKAAICLHNFLMNKENSRPFQDRRYSLLSESDREYNILGCTNVSISSEIPSENAETVRNMFKDLFCEDGAILLEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F619</accession>
    <name>A0A232F619_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000919">
        <property type="protein sequence ID" value="OXU25898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F619"/>
    <dbReference type="OrthoDB" id="7697863at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="302" mass="34980" checksum="1AC48E65D7A0DD66" modified="2017-10-25" version="1">MILKLDPLAIDDDYNYTMPRRRNRRSADVSNQNFLCGQCDRGYTRIENLMRHQRLECGKEPKRYELKNHNEAKHSRLNQEIVEPEELFSTFMFILSTRNFQILMYALEEISDLLRDISKCQKATKTALTNVSSAQIIVKPDDVKPAVTNDINLPAACDFGFADKYSIDLPMKELAEFHEFEDMLKNDEAMRKDFSAVLPSLVDRHNIASKSTTNILRKFFTRAVVLKFTVQKKISDKIVLKDTCFCKCTIEVLIKMHKDNQGNPITEKDVYSAFGSSLNNAKDWDGYRSQRKEKEKKVVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F658</accession>
    <name>A0A232F658_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000817">
        <property type="protein sequence ID" value="OXU26346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F658"/>
    <dbReference type="STRING" id="543379.A0A232F658"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000177">
        <property type="entry name" value="Troponin C Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="140" mass="16134" checksum="30C64C2CD7EDB5E8" modified="2017-10-25" version="1">MRKAFDSFDREKSGSIPTDMVADILRLMGQPFNKKILDELIEEVDADKSGRLEFEEFVTLAAKFIVEEDAEALEKELREAFRLYDKEGNGYIPTTCLREILRELDDQLTDEELDIMIEEIDSDGSGTVDFDEFMEMMTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6N7</accession>
    <name>A0A232F6N7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_003326</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000868">
        <property type="protein sequence ID" value="OXU26140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6N7"/>
    <dbReference type="STRING" id="543379.A0A232F6N7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU26140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="60175" checksum="02ED9807DA0DDA73" modified="2017-10-25" version="1">MTIYFLLIFLVLLFYRIYARNIKSRSLLKKIPGPPTLPLLGNLLIFNVPVEKQWDIVRSLTKQYYPICKIWLGPRHAVVSLLHPDDIEVLLTSSKHINKGDSYTYLHTWLKTGLLTSSGDKWRQRRKILTPAFHFNILKKYMDITNENSINFIEALRNEGEETIQNLTPLCSKYTLNIILESAMGIVLDKVDKKTADDYKNSVYEIGRIIMYRLARRYIREWMLNPLMNLARVQKRVLRTLHDFTEKVVKDRREYHERTENKYLDNFTNDVNESHCDDVYARTGGRKKRMAMLDLLLSAERDGLIDDEGIKEEVDTFTFEGHDTTAMAMTFALLLLAENKKAQDKAREEITEILNRSEGNMGMTQIQEFNYLERCIKESLRLFPPVATMARTITEDLQLKNYLVPAGTEVMYHLWEIHRDPNFWEEPLKFDPDRFLPERSHGRHPFSYVPFSAGPRNCIGQKFAMMELKSLIGRILYNFKLESIDKTTDMPMLLDIVIRPAKPVYTRFVRIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7F4</accession>
    <name>A0A232F7F4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000804">
        <property type="protein sequence ID" value="OXU26420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7F4"/>
    <dbReference type="OrthoDB" id="6424487at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="741"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="836" mass="96316" checksum="E24CA4416C7FFA1D" modified="2017-10-25" version="1">MGIETVEPTCEARLRHVKRGERRVAEMECRVRTLREKLCRLEKLLPQKDFVERAKLDCAANDKAEYKRETDDAANVCPIDEIARKEKFLRKQIYDMECTEKDYMRQIADAKNKAVTEEPKTSSTTKCGTTPRKNREEIAKERLSLLESYSQRLSSNLQTLEKNHVGLTQESRRLSQVLDETRKDCFEKQEVKKDTSPCGKRETKPDSPKKIEQNVECSCKVLPKCDSCIVCSCDEWERDLETTNEEEEPVKKRDSAKKTIVSTKRTPRTKEKCTCYEDAASSSSDSDGPCECQKVQCKPVKKVNCCDYEDVDVESLSSNDSSDIQTFYSEQSKYTCFCSRNHSHEELTLESDNNFVPNGTMYPKSRKIERIRGGRDIAREKSTALSVQRTQKLSAAFPPVQNSIVDQLKVTIRYNYFNESCNSSVYNSQKQIVKVDELREGLERLKIRNRNLKDFLHSLENPMNLFSKPSEVFSTTCTEVSSSYTLDLVGQSHSGLLSVVKVLEDKCRSKDAIIVALADELKTNASKKLRLRGKELTNDRTNIWKSLSKKKNGRRFTKKDSAIGFLVFLLILVSHVKRSEMISYLSAVKKILTESPFRLITFINESEKISADYVSAIQSRFSVLTKRFVTSASFSWRRMQIWLSELLNLTVILADSIYVQLNAHMLTVAEFLVANQVYIVSTSCFVYTVWLVIKFRKYVTNRARNFSFTPIYRFSNFHKSVLTAYTEILRMIKERLLSSRIFWLILGFCGHMLWSLVSADIIGLIYAYYPRNEEELDQQTLQLSEVVDAASCECDLYHQLVNYSWLFSTMCSKLQTFIEFTSYVLQNFLCDEAAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Q7</accession>
    <name>A0A232F7Q7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000763">
        <property type="protein sequence ID" value="OXU26632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Q7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="35" mass="3870" checksum="23338399A4AB5419" modified="2017-10-25" version="1" fragment="single">STTTRAQTSSGKAHLPLVVHRAFYNKCIRKTILVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8R1</accession>
    <name>A0A232F8R1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000118</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000747">
        <property type="protein sequence ID" value="OXU26707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8R1"/>
    <dbReference type="STRING" id="543379.A0A232F8R1"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="395"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="639" mass="71041" checksum="0C4D6292FFA8BAFE" modified="2017-10-25" version="1">MAGFLTGPAAHLVGAGMQAIGVGIPVGQTSAKLIDGMRDVGIPVPPKSWFKRKGSKDDPEIVGNNIKASKSPKKNVYDKLEEHIHGVIQVVRPVIELKQMVREGCCKSADRAKRADRSPSPSRDQRLKYYTPQKCSSGYRENDFVSRGDSAYPSQKRKVASKKSISRRKDSIDDDTDDELDGAATAAPRKSCIYCSRSKRLLELPCGAVICSKCDETENHERESKMPRRIRNLRSSKDERVTELITPDQLEPVDIIDLTQDSPMNTALRLSRARAGHNPEEVAIEQDQSEGDSVILTDESDSTPMAKKPKLNGCEGIEKRIMTVENASAERVMPVHQINVNPPDWQPSQSLGSANSPNSPTAGEQQLPEWTPREPAYAPVVTVIPDHCHSSVSTLSSSNHDICRICHCEGEVGAPLLAPCYCSGSLRYVHQACLQQWIKASDTRACELCKFTFIMHAKTKPFSEWEKLEMSAPEVRKLWCAVAFHAVAALCVAWSLYVLVERTVEEARRGFVDWGFWMKLIIVVIGSTGGLVFMYIQCKTYIMLCRRWRAFNRVIFIQNAPEKVVLPPSPTDSLREVTVPLKDPTASMPELNRSLLPRSVEPPCASQTVKPDSASISQRHDAQLKLYVFDKLSSSEDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F901</accession>
    <name>A0A232F901_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Group XV phospholipase A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000623">
        <property type="protein sequence ID" value="OXU27331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F901"/>
    <dbReference type="STRING" id="543379.A0A232F901"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127330" description="Group XV phospholipase A2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46484" checksum="46B710802D011FA2" modified="2017-10-25" version="1">MRLGSVSCLALLLFCCISLTQTFRFRGNQRSPVIFVPGDGGSQVEASVNKTTVVHYLCEKVSSGFFNIWLNLELLVPIIIDCWIDNMKLLYNNETRKSRNPDGVDIRIPGWGDSFVVEYLDPSKASPGAYFKDIANMLVKDLGYIRNVSLRGAPYDFRKGPNENDEYFVKLKDLVEETYIMNNNQPVTLVAHSMGGPMSLIFLQRQSQKWKDKYINSLITLAGAWGGSVKALKVFAIGDDLGAYLLRESILKDQQITSPSLGWLLPSKLFWKEDEVLVQTQLRNYTFADMRQYLIDINVPNGWEFRKDNEKFQLDFRPPGVELHCLHGVKVDTVERLFYKPGISIDGYPQQIPGDGDGTVNLRSLEGCTYWTNKQKQKIYHQPFPGVNHMQILNNGSVLDYIRNVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9C4</accession>
    <name>A0A232F9C4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000676">
        <property type="protein sequence ID" value="OXU27058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9C4"/>
    <dbReference type="STRING" id="543379.A0A232F9C4"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02991">
        <property type="entry name" value="UAS_ETEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="5">
        <location>
            <begin position="371"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="452" mass="52421" checksum="DBA8C1CAA647D864" modified="2017-10-25" version="1">MADFDLGDLIADQLDKVLQFQDLTGIENLSVCRDVLQRHNWNLEVAVQDLKWSREFMHGVLLDNLIQEQLNLYEGRPSMYAQDSRVRPPPVVDETSTRIYFSPPGSSGGGGFFSYVFSLCYNVVTSILQLIFAMFRRNVRPVSVDPVQDVMNFIHAYNEQYGINHPVFYQGSYSQALSDAKQELRFLLVYLHKDETQEVDQWCRNTLGDPEVVRYVNTHTLFWACNIKSGEGYKVAEALKAGTYPFLAVIVLKDNRMTIVGRMEGIPSPRELLARLQTIIDNNEINLIQARQERAERSATQSLRQQQDQAYEESLRADQEKDRRREEERLAREAEEAREREQLNAIEMEIQRIKMEKERTVEKVPSEPEPTNPDACHLQIKLGERTVKRRFLLSHTIQDVYHWIFSQPDSPANFEITTSYPRRILYPSVEILSLLKAGLTHREVLHINDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9U6</accession>
    <name>A0A232F9U6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000639">
        <property type="protein sequence ID" value="OXU27250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9U6"/>
    <dbReference type="OrthoDB" id="7675754at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032004">
        <property type="entry name" value="DUF4790"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16037">
        <property type="entry name" value="DUF4790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="10006" checksum="BF1E1CE9DF7FB51A" modified="2017-10-25" version="1">MNSQTKEDERDGLEKEETHRSEASIHPSYTTGFLTFPYDVICRRRLARKKRRFAAQINREINHIIAMKMRAIDGIRLELLFTING</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAB6</accession>
    <name>A0A232FAB6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_008606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000605">
        <property type="protein sequence ID" value="OXU27420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAB6"/>
    <dbReference type="STRING" id="543379.A0A232FAB6"/>
    <dbReference type="OrthoDB" id="7555456at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="387" mass="44352" checksum="3AA1D2078A792FAC" modified="2017-10-25" version="1">MRSNLSRALNKAERNYSTIEKECLAVLFALHQFKPYLLCRKFTLVSDHEPLNWMHTRKDPAQRLMRWMFRFTGYEHTFKYKPDKLNKNADALSRNPPEMTEKKINENLPKIKVMIIDEKTKQSGNKTKSNASTDATTFQNRAHSAYERTTAPRGRGRPVGAKTNKNAPKLDHSVIAQRTRGRTTKVESPIATYIKQGAIPKVPKTVKSTKINKPMDKPLLKVTKPTPETIAISEEESIKDTQSKTDSEASTSEKLSPSSRSWLSSTALEGSETERPPLLDPRYSGLRTEDYQSEDPDSDGDTSSTDSQNRTIRNIDKEEVEEASKKFEESLKRYQEKSIIPEKEEIDSEQELITDLPLCLSQEEEITEQMRFRIHELNPHYGTELMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAN2</accession>
    <name>A0A232FAN2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000552">
        <property type="protein sequence ID" value="OXU27715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAN2"/>
    <dbReference type="STRING" id="543379.A0A232FAN2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="324" mass="36764" checksum="DF90311EF3DEE9F6" modified="2017-10-25" version="1">MSYKALDETSDRIANLLRRYGKTRDSIIAVSLKPSEKLPLILLSILKAGISYLPIDVEFPVDRVQLILRDAQPVLCILEETADSSVYNDVPTLTVNDVLLRSEHESAEIAVDENIFKIAIILYTSGSTGTPKGVRLPYSALLNRLAWQWKTLPYASDEDLCIFKTALTFVDSVCEIWGPLLQARTLVVISRHVTKDPERFTAALNKYKIQRIVLVPSLLKSLLIFLRLQQDKRSLGSLKLWVCSGETLVASLVQEFFNWFTDEKKTIANFYGSTEIMGDVTYYLINKDDPYLKEGTIPIGKCTINLATGHFMRRIEREREREIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAS9</accession>
    <name>A0A232FAS9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000603">
        <property type="protein sequence ID" value="OXU27437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAS9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7940" checksum="998CFB39E96DBF2A" modified="2017-10-25" version="1">MIVPISLDTPCLLDAARVSRKWLAVSKFTFTFRQQVRRHILRRNQRLVQTKVSYPNIFNNSKLLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB51</accession>
    <name>A0A232FB51_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Death-inducer obliterator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_013016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000481">
        <property type="protein sequence ID" value="OXU28074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FB51"/>
    <dbReference type="OrthoDB" id="1884872at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15552">
        <property type="entry name" value="PHD_PHF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006576">
        <property type="entry name" value="BRK_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037259">
        <property type="entry name" value="BRK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF51">
        <property type="entry name" value="PROTEIN PARTNER OF SNF, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07533">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00592">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160481">
        <property type="entry name" value="BRK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="956"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="1325"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1216"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1260"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1493"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1953"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2052"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2138"/>
            <end position="2171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2188"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1262"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1295"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1495"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1542"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1567"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1596"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1622"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1641"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2004"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2143"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2188"/>
            <end position="2201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2208" mass="242254" checksum="65D82BDB8276AF85" modified="2017-10-25" version="1">MSSSYIVEPQEGASKKDDTLILMVNDNGVISVDQDTLQNLILNQSNANVSVVRLGQTDNDAAEGNITLTVDPPPFVASESNVANSAADPAGLVDPFMEMDPEQLERLETALQSEEAKQILGENVTAMLDMLTVEEQQNSIRYSIELDHCYTSRFSPSQPKPADPLPDMSSSDMDESMCLDSNKSTVPMMLPVSSANLNNTSITPMKQKVASIPPKIVKQPVSLGSRPRRASAAMQPITTTPKSSISTNARASNLTQQENKSNAKDVNEPEDDQLFSSSSESSESEESFSDSGFGPKPFRKGVRARGGRRGLTTRGGSMAAARRRGTNKHMDSEQVRRLDLEMAAAVNAMKSPEKEDKSEKHSPGKVKKPLKTFGGKKKEDGPTPSTHVNESPPVEPNVIQTTNQVKANLISANMFKGDMILTKPGQDRNNQKVVYIQKQVTMSPNDMKALGIKKQVMIPKSKLITSQNYKVPMAKDAKAISSPATVKGVTGNVQLATVAQTVTPMEVQMDTMQHQAQTQKTVSSAVIKTKPVELKKEKKKTETTSETPVKAVESAKPVEIKTPATVPKKVVKKEHRKSDPHVVEALGPALFSTPDIIRRVGSTESKVPDSPVTTTPTNLSAVINNANISTSVVSTASIPTVATPSLSTAISPINAAGILHEPMDTNISSTDSTNDGLARLDTNASLLPESLEDDKMDSKTAIAELLQPALEAASKPSPSKEMPPSMEQNSSSKHVVSESGIEGDDHLLATLGMEAAKQLPNDEELLAEALLLQETLGVDLDHSGLVDPTPEIPDSILSSPIMEPPPVVPPTIKAAEPMPIAPPVQTSVSAIPLAPLTPEVKSESIVKKDSKPIQIVRHGRVITLPPIEAPATRSKRLQAKTDNQQPDVAQAKVEKKPQVQQHHQQQLKVKPIVIKTERSSRTPSHVSLKKQDMIYDMDDDDEEEEANSDSEDDPNRLWCICRQPHNNRFMICCDICQDWFHGKCVNVTKAMGEDMENKGVEWVCPNCKTKKSEESKPKSTARKQKHSTDLTASERSRTLSVSNTSTSDGKVTSNTGKNSGALAGVTHCVVCKKEARKSSIYCSDACILAHAEKTSTQDKPAPSPQPVKTPKADTSKSKADVRVVVFDKKTGNVLTGSNAPTTSNLKAWLKENPSYEVVKPNNTNTIQLGGKTFTAIQTQGIKTNKPLQGKTSAQAKMVYSKVAGSKQTVLAPSTKKTVLTIDTPPGRATASPQHRPKQNAVVTPYKTPTSNLKQTTIKSVVQPNQQQQQQQTPQKPIAASTPKVVSVKKPAEPKPSTSQQKPVQSPKEQIAIKTPPPRKPETEPIRLTVRKTLAELLTSRVKEANDLAITEEEISELALQIELEMFKFFKDTGQKYKSKYRSLVFNIKDTKNLTLFRKIADRSLSPAAVVKLSPDEMASQELAEWREKENKHQLEMIKKNELDLMAQAKSIVVKTHKGEQIIENASAIDSIDPKTSVQDIVTALNSGDSISSTMEEDKLKEDKLLDESKKPKTLEDEKKKKEKDRDRDKRRGRSRDRDSSHKRDRSRHKHSKDRDRSRDRKSKGKHKDRDRTREKDHDKSRGRDRKKDKDRDKDRKDKHKRSRSSSRSHSKSRHKEHKDKHKKDDEKKKEGSKIDGVGMEKPIEDRLWRHIEEETTTNTLDGNESDISDREPSSTVTIKTPDINEDLDREIDRELEKEIDKSAKLANESALATTAKGSITVWRGFVYMADVAKFFVTAQNVSGNSKEFLEGLPETFDVVGRISPNIVWDYLAKMKKSGTKDILIIKLTATNDEEKIPYITLYSYLNSRSRLGVLGRISPQIKDFYIVPFSHGSKLPLVLLPFDGPGLEENNQHLLLGIIVVHRIKKRVITNPSSLTPTPAKIAKKEPLQIGDTNYTSPVTSHLLAGSSIKDESMTPPSSPRASISQVRIVTQEVKQSFSIISKVVPELSSKITLESSSSSDKMQLDDDEPYSPGEPVDIVLEDDEDALSSSSSLKPAGLDAASIATTTTPIKSPSQLQREMEEVSRQIEEEKMQIQNISSSFLSEASTTLPGLGLDPPDNSEVYSPSDARSFTPPPQGIPKLTQPILDKVSNIMIPPNLQEILANVKRQESTKVDPYLPSKPSATFLTTANSAMYQNPEKYSPTYSKTSNVNTEVQSSPRKETKSTLSSLSDADLCRKAEEELAALAAASAPTVATSVPSAQSPAHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB63</accession>
    <name>A0A232FB63_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000553">
        <property type="protein sequence ID" value="OXU27709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB63"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="159" mass="18942" checksum="032FFCD74071AC08" modified="2017-10-25" version="1">MDLLPYTKDRRLDFDTARMFSGFKLDDHPNCSICSDATEDVEHVFCECSRYNQKREELEIYLQIRLTPKSIITAMLISKDGSCSQQLYSRNSLKSQERRRRQKKTKRKRTWESQLLPLCLDADEDVEHVFCECSRYQQERENLEDYLQTRVTPESIMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB65</accession>
    <name>A0A232FB65_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000480">
        <property type="protein sequence ID" value="OXU28084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB65"/>
    <dbReference type="STRING" id="543379.A0A232FB65"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012330643" description="Glycosyl transferase family 25 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="318"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="564" mass="66060" checksum="DB21157E3D8CDFF0" modified="2017-10-25" version="1">MNYYLVLLLCVLKIINSEETFKKPNILVGILARNKAHTLPYTLSYLEKLDYPKDRIALWIYSDNNVDNTIEVLKKWLTVQKDNYFMVNATLDEESHGHDDEKGIADWSSKRFEHIIKLREEVLNYARRIWADFIFMLDADVFLTNPKTLDSLIRKNETVVAPLLKSDGMYSNFWAGMSDDFYYKRTDDYESILNNKVSGCFPVPMVHSAVLIDLRRKNSDYLTYNFKNINNYNGPIDDIITFALSAKYSDISLNVCNDQKYGFIMVPLQSDDSFDHDYQQLVNVKLEILAAGDQEYIELTESMKPFVNYPEKDSMDFSNVYMINLLRRPERRRRMMSCLNELGIQVEIIDAVDGRVLNESLLESWNIKMMPGYKDPYHKRPMTMGEVGCFLSHYIVWNRIVEDGDKISLILEDDVKFEPYFRQKIKLILNELERFKKDWDLVYLGRKQMQRDTESWVEGSRYLVHAGYSYWTVGYMLSAKGAKKLIDAKPLESLIPVDEYLPIMYDKHPREDWKEYFNDRDLIALSAEPLILFPTHYTGDSGYISDTENSVLLPAEEMPSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB71</accession>
    <name>A0A232FB71_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000555">
        <property type="protein sequence ID" value="OXU27698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB71"/>
    <dbReference type="STRING" id="543379.A0A232FB71"/>
    <dbReference type="OrthoDB" id="190835at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF46">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="100"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="209"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="340" mass="37780" checksum="ADA4AB8DC47B855B" modified="2017-10-25" version="1" fragment="single">VEKAAEPADLSCTHPESWLSELVVISMQHFQKSPSRVLALVHMLYERILANNIMPKFFLFADTLSLGDRPMDTAERHSSASRPRQQLLDTTASQKSKLEPGFDLLQPTNVTALVGKTAYLTCRVHNLGDKTVSWVRHRDIHILTAGAYTYTSDQRFQALHKPNTGSNNEWSEWTLCIKWAQERDEGIYECQISTSPLKSHQYHLNVVVPTATILGGPELYVGAGSTINLTCAIHFSWEPPAFIFWYYNGAVMSYDSPRGGVSVITEKGNDVTTSWLLIQAAQPSDSGEYRCKPSNANMSSIRVHVLNGERPEAMQTGTAGPTLSSSCLLVSLIILYISYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC77</accession>
    <name>A0A232FC77_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000488">
        <property type="protein sequence ID" value="OXU28048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC77"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="28" mass="3326" checksum="9A58974FEBE3314E" modified="2017-10-25" version="1">MDLSLYFSLWHLFVFKELSGVCYTKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCJ2</accession>
    <name>A0A232FCJ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_006138</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000418">
        <property type="protein sequence ID" value="OXU28541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCJ2"/>
    <dbReference type="STRING" id="543379.A0A232FCJ2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="61830" checksum="3B985A8D1E47C309" modified="2017-10-25" version="1">MFETVGSVLNFKLFWISAIIFVFYSYFKLIIYSYWKRHDIPHDKPTVPFGNIGMDLITKKVSIGEKMKFSYDKYKKHPFHGLYMFHKPTLMVNDPEVIKYVLVKEFTHFHDRGMYFNDKIDPISGHLFFMTGDRWRALRIKLSPSFTSGKLKNMYPFVQEIADEMVNIASENLEKTNVLEIKELVARYTTDTIFSLAFGFNANTLRNPDSEFRHYGDLSIKNAPLFNAIAAFTPYILEFFKIPFTNAKAAAFFIKLFKDMIEQRKMEKKNRKDFLNLLIELIDHGQIRDQEGENSTDEPVNLTKLKLLEAVAQAFVFFLAGFETSSSIVTHTLYELALNPDEQEKLHQDIDELLKRDGGFNYENKWHFMVSQAISSHKLSYEGMAMLYNADYAISETLRKHPSLPFLNRICVKDCKLPNSDFVVPEGMPIIISISGLHRDPNIHPDPDKFDPTRFSKENIAARHPYAYLAFGEGPRICIGKRLGIMMSTVALATLLSKFKFSVCDRTPIPNRYSMNSILQTPGDGIYLGMEKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCL6</accession>
    <name>A0A232FCL6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000415">
        <property type="protein sequence ID" value="OXU28561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCL6"/>
    <dbReference type="STRING" id="543379.A0A232FCL6"/>
    <dbReference type="OrthoDB" id="78437at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12366">
        <property type="entry name" value="RRM1_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12368">
        <property type="entry name" value="RRM3_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12369">
        <property type="entry name" value="RRM4_RBM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034203">
        <property type="entry name" value="RBM45_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034207">
        <property type="entry name" value="RBM45_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034208">
        <property type="entry name" value="RBM45_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="141"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="502" mass="56171" checksum="38A5368ADCD857AA" modified="2017-10-25" version="1">MADHRERGEYYGGGADLRCKNDEPPNSRLFVICHKSLEEEELRKAFEKFGNIEDIWVVKDRNTGENKGKIRVYLLLIIVARVTYIKYAKTSQAAFALEEMNGKMLSSVGRPIKVMIASNRDQGSVRETNEEERWVRLFCVLPKSMTDSELQQEFSKFGAIEYVTVVKDRSTNESKGFGYVKFKKVSSAARAFEECDRKYKAVFAEPKKPKPDPDQKFSNGMSMGYDNSNNSNYGNNYGKSSIGLEIATNYPNPEGYTKLQVIAHPALNQDQLWKLFDIVPGMDYCHLKTDARYRMPRGQATVVYTNPNAAAYAREKFHGFEYPLGHRMIVKPDLTGALPQKPGLKQGIPSNNITTPGGVVAARTDLAQLAETIAQATSLIQQAGLTAPIIDPSICKLPPMQPMASIDADVAKRCFIVCGPPVPPIYAMKDAFCRFGNLIDVYMLPGKNCGYAKYASVDSANKAIEALHGQEICGSRLKVLEAEERNVGDDRRKRLRMDEDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD21</accession>
    <name>A0A232FD21_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">ATP-citrate synthase</fullName>
            <ecNumber evidence="23">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">TSAR_010773</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">Alberta</strain>
            <tissue evidence="30">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 23">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 23">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="23"/>
    <dbReference type="EMBL" id="NNAY01000459">
        <property type="protein sequence ID" value="OXU28247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD21"/>
    <dbReference type="STRING" id="543379.A0A232FD21"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="29">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="28">
        <location>
            <begin position="244"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="27">
        <location>
            <begin position="482"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="26">
        <location>
            <begin position="647"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="24">
        <location>
            <position position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR036511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR036511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="OXU28247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119604" checksum="C62C450870A66771" modified="2017-10-25" version="1">MSAKAIREATGKDLINRKLAQGTRAAKCRFVSIDESTNWSHLVSENPWLSSERLVVKPDQLIKRRGKLGLIKVNADLAQCQQWVAERLNKDQQIGKATGKLKTFIIEPFVPHKPEEEAYVCIYSHRTADTILFHHEGGVDIGDVDAKALKLDVPVDSDIPDESTITSRLLTHVANDKKPVIAKFIQSLYKLYVDLYFTYLEINPLVVTDDSIYILDLAAKLDTTADFICRPDWGEIDYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNPSGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILGLMTKEKHPDGKVLIVGGGIANFTNVAATFKGIVKAAQQFQPKLVEHDIKIFVRRAGPNYQEGLRIIREVGKRLQIPVHVFGPETHMTAICAMALGKKPIPDPEAQEFSTANFLLPSGQDVGPSAPSSAATSPCTPTKQPRVQKSDSVDSSFKPLFSSKTKSIIWGMQTRAVQSMLDFDFVCRRTEPSVAALVYPFTGDHKQKFYWGHKEVLIPSYKNMKDAMAKHPDADVMITFASLRSAYDSAIETLQFPQIKTIAIIAEGIPENMTRKLILKANEKKVTIIGPATVGGVKPGCFKIGNTGGMMDNILHSKLYRPGSVAYVSRSGGMSNELNNIVSKASNGVFEGVAIGGDRYPGTTFMDHIMRYQNDPDAKLIILLGEVGGVEEYEVCEALKSKRITKPLVAWCIGTCASMFNSEVQFGHAGSIAHSNLETAVAKNEALKAAGAYVPDSFDNLGDLIHSVYEQLVRDGTIVPEPEMPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELLYAGMPVTEVLKQNVGIGGVVSLLWFQRCLPPIYCKFLEMSLMLTADHGPAVSGAHNTIVCARAGKDLVSSLVSGLLTIGDRFGGALDGAARMFSEAYDAGLHPQEFVNNTRKKGKLIMGIGHRVKSINNPDMRVKLIKEYVLENFPTKPLVEYALEVEKITTTKKPNLILNVDGIIACAFVDMMRNSGSFTREEAQEYIEIGAINSLFVLGRSIGFIGHYMDQRRLKQGLYRHPWDDISYVLPEQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDH6</accession>
    <name>A0A232FDH6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000415">
        <property type="protein sequence ID" value="OXU28560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDH6"/>
    <dbReference type="STRING" id="543379.A0A232FDH6"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06860">
        <property type="entry name" value="PX_SNX7_30_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="77"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="471" mass="53892" checksum="5C6336AFCE34BDAF" modified="2017-10-25" version="1">MMTPTDAELDESGQQEDAVPEITAVLEVSPMSTAAKPEDGLSNYSTSVEGSVVASPSIESFSTFPEQETSDTNVDLRDLQVKVESPQKHVETLETYITFRITTRSTRPEYEEGEYIVRRRYNDFIWLRQKLVESYPAHIIPPMPGKHSLLAQLDRYSKEFIIARMKLLHIFLNRMVNHPILSYDKNLHVFLTAKPAEFSVYRKNRGNAMGKVSDSLQSMASSGVVKQRHLEFEQARDYCISLSEKLSTIDKISRRIHKERQDYLVELHQLHPIFTLWATSEPELARTLQAVAGAIESNASAHQKLLDTAVNEEREYITYIDAVKDALSRRDTMQVEYEMTAEELTKRKTERDQIVSSGNITSSRWDNSFWKTESNGEKLDRLSQTIPRLSKVVEVLQDRLECANENLRSDLERWNIEKRTDLKNILIAMADQQIAHYQQCTNAWEEALSVVKVGNNDASESATSPPNRVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDZ7</accession>
    <name>A0A232FDZ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000386">
        <property type="protein sequence ID" value="OXU28750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDZ7"/>
    <dbReference type="STRING" id="543379.A0A232FDZ7"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850600" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11379" checksum="745095F3C50F1994" modified="2017-10-25" version="1">MFSCWSLLLILQPTLAGVIDPTSLLEDFEVRISRLERRLRAVEQPVWHISGVEGGWDGCAEGPCKCRVETRSLSCWSMGLSDLPPTQLVPKNILKLQRSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE68</accession>
    <name>A0A232FE68_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000340">
        <property type="protein sequence ID" value="OXU29076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE68"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="11513" checksum="396BC246ECD553AA" modified="2017-10-25" version="1">MKEYFVNSWVSAEGLVKLHESDNNNNNNNNKMTTDEPYIVFPVVAVDMCSLRTLQLLYHTTPPEFLSARQLISMGKKKAAYTNNKLRNDDDDDDERAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF42</accession>
    <name>A0A232FF42_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000330">
        <property type="protein sequence ID" value="OXU29173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF42"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="18787" checksum="10AD89927402518E" modified="2017-10-25" version="1">MTDSNVPNVKLKVTKRLQSAWGDLIVSKVREKHRIRCPFKQRSEDAKRVKFIINTSDTRGINHVKSARPLAKEQIDDLALHEDTITAILVICQSQSIDEGTWPNVMHRFYEFEPNKVSTPTASECYYQIMRREYGFNCPVGFNRFILLHIPLIDKATKLKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF87</accession>
    <name>A0A232FF87_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000292">
        <property type="protein sequence ID" value="OXU29421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF87"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="8211" checksum="70BF39C9B01804A1" modified="2017-10-25" version="1">MQQLDLLIQEIESIDDYLGPTFREPLPERVEARRFGSSQTETALIYDQLTHMRTGRGMYLSPRLLRRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF89</accession>
    <name>A0A232FF89_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prolyl 4-hydroxylase alpha-subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000322">
        <property type="protein sequence ID" value="OXU29223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF89"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012150027" description="Prolyl 4-hydroxylase alpha-subunit N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23590" checksum="A4BCC36D40245B0A" modified="2017-10-25" version="1">MKLIFTTLGFLATICGSLGMSNLETATTILDEVKYLKNEIANVQRDVEYLSVKKLLENPHIHKIQVALEKAWQSQSITADCTVSLDNSFKILVEKVNAELLPEILKNVTEDANFFDNTQKELNEIEKSLEQIQKDDKASSSNNDEENRNLILTYLDKTEKLFRFVDPQQYRVLDMISSSPYFDSEDVLKRVKDDFVTPSTNCIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGE2</accession>
    <name>A0A232FGE2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Gem-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the core SMN complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000231">
        <property type="protein sequence ID" value="OXU29831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGE2"/>
    <dbReference type="STRING" id="543379.A0A232FGE2"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017364">
        <property type="entry name" value="GEMIN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038038">
        <property type="entry name" value="SMN_Gemin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="244" mass="28003" checksum="D172D1EE5C2D4AB8" modified="2017-10-25" version="1">MNERFKEPVLFVGDIEDDINLSMPPATGEEYIKRVILEARQCEDVVCAKIDEARLKKPTLNVKPLPECAKAPDYVSPTMEWQHCQLADFSHSRLYIAQIREEITNCNRKKKPMKDKLPDVNDQTRWIDMCTASDEKKTLYIEPTLTVILSMNQPTIEQVLEYLVEYLEEQISIQPPLGRWLYALLSALELPLNPDMCSCLRSLARTCSKMRSQLASSCANDAISLNLFICLVARYFRQLDLADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH45</accession>
    <name>A0A232FH45_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xanthine dehydrogenase</fullName>
            <ecNumber evidence="6">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSAR_015306</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Alberta</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000242">
        <property type="protein sequence ID" value="OXU29769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A232FH45"/>
    <dbReference type="STRING" id="543379.A0A232FH45"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000009">
        <property type="entry name" value="Aldehyde oxidase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014309">
        <property type="entry name" value="Xanthine_DH_Mopterin-bd_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02965">
        <property type="entry name" value="xanthine_xdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="22">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="23">
        <location>
            <begin position="262"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="22">
        <location>
            <begin position="1336"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="23">
        <location>
            <begin position="1570"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="22">
        <location>
            <begin position="2692"/>
            <end position="2767"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="23">
        <location>
            <begin position="2912"/>
            <end position="3098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00053333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OXU29769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="4013" mass="446244" checksum="F454878120B16AA6" modified="2017-10-25" version="1">MESHTYKEEIENELKANNDALNDTNSIKISNTLVFFVNGKEVRDSRVEPEWTLLCYLRNKLNLYGTKLGCAEGGCGACTVMVSRYDRKQDKIIHVAVNACLTPVCAMHGMAVTTVEGIGSTRTKLHPVQERIAKAHGSQCGFCTPGIVMSMYALLRTKPLPSIQDIEVAFQGNLCRCTGYRPIIEGYKTFTEEWEKSRLSRNDEGKDRTCAMGDACCRRVFTSEPQEVFDTNTFTPYDPSQEIIFPPKLQLSSEFDDEYFIMKGKEVTWYRPIHLREILALKQQYPNSKIIVGNTEVGVEVKFKHFVYPVLIQPIKIKELRDITELNDAMRIGAGVTLIEMEEALRHQIQTKPEEKTRIFDSIVGMLNWFAGKQIRNVAAIGGNIMTGSPISDMNPVLMAAGIKLNVCSLERGVRSITMDHSFFVGYRRNVVAPDEVLLSIEIPYSTPNQYFVSYKQAKRRDDDIAIVNLALNVFFEPGTSIVAKSYMAFGGMAPTTILARKSCEAMIGKKWNEQLVEAVTDSLVNELPLSGDAPGGMVLYRRSLTLSLFFKGFVCITKKLRINVNDVDPLPKELETAGEGFHFQAPKSSQYFQVVPKDQSSIDLIGRPIIHINAFKQATGEAIYCDDIPRITGELYLALVLSTKAHAKIVKIDPSQALAMEGVEAFLSAEDIPEKQRIIGHKCFDEEVFVSKIVTSQGQSLGAILAVDQITAQKAAKLVKVEYEELQPIIITIEDAIKHKSFFHEHPTVICNGDVDKVFAESDHVIEGEVRMGGQEHFYLETQASLANFREEGELELFSSTQNPTEIQKLTAHVLNLPISRINVRVKRIGGGFGGKETREALVALPVAIAAYKYRKPVRCMLDRDEDMMITGTRHPFLINYKVGFTKDGLITAAEICLYNNCGYSTDLSPAVLECAMFYVLNGYKVPVAKVSGYMCKTNLPSNTAFRGFGGPQGMFCAENIIRHIADYLGRDQVEISEKNLYREGDITFYNQPLIKCTLRRCWEECLFSANYKERVTEVNQFNKEHRYKKRGIAMVPVMFGIGYEVAFLNQGGALVHVYTDGSVLLNHGGVEMGQGLYTKMIQIASRILKVKPDKIYTAETGTDKVPNTIATAASLGSDLNGMAVLDACTKIMERIKYIIDDDPEGTWEDWVKRAYFDRVSLSATGYYRTPEIGYDFDTNSGRRFNYYTYGTACTEVELDCLTGDHEVLRSDVVMDLGESLNPAIDIGQVEGGFMQGYGLFTMEEMVYSPTGIVFSRGPGVYKIPSFTNIPREFNVSLLKASSNPRAVFSSKATGEPPLFLASSAFFGIKEAIRAARKDMGIHGYFRLDSPATAARIRMACVDQLTKKIKDCNIEPEWTLIYYLRNKLGLCGTKLGCSEGNCGACTVMISRFDRKNNKIIHLAANACLTPVCAMHGMAVTTVEGIGSTRKKLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRSNPKPTMNDIDIAFQGNLCRCTGYRPIIEGLRTFTKEWEQSRMSKLKNHEEKLCALGNACCKKAFTSEPTALFDSKEFTPYDSSQEPIFPPSLQLSSNLDDEYLIISGKEVTWYRPTQLKKLLILKNQYPNAKIIVGNTEVGVEVKIKHLMYPVLIQSTAIKELKIIEEMNDGIKIGASVTLVEMESALRHQISTKHESRTRIFGSIVKMLHWFAGHQIRNVAAVGGNIMTGSPISDLNPIFLAVGTKLNLCSLNNGHRSVIMDNKFFLGYRRNIVAPDEVLLSIEIPFSTPNQYFVSYKQSKRRDDDITIVNMAMNVFFKPNTNIVQKINLTFGGMAPITVLAKKTCESLVGKNWDESILEAVTNNLVAELPLPGNAPGGMILYRRSLTLSLFFKGFISISKKLHKDIPHIAPVLKELESASEGFHYVPPKSSQYYQMVSKDQSSIDLIGRPLIHASAFKQASGEAIYCDDIPRITGELYLALVLSTSAHARITGIDNSKAVALDGVVAYFDAKDIPEHCRFVGPIIEDEEVFVSEKVTCHGQVIAAIVAVDQVTAQKAARMVKIDYEELQPVLLTIEDAIEAKSFLEKDGRSITKGNVDEAFTNVDHILEGEIRMGGQEHFYLETQCSIAIPKEHEMEIIASTQDLTEMQRLIAHVLDIPINRVTVRTKRLGGGFGGKESRSMLVALPVAIAAHSLQKPVRCILDRDEDMMITGTRHPFLFKYKVGFSNEGLIKVLEVYVYANAGCSWDLSGPAISRTMAHIENAYRIPAIRVIGYLCKTNLPSNTAFRGFGGPQGMFCAETIIRHIADYLDRDVVQLSEINLYKEGDITHYNQKLENCTMQRCWIECLAFSNYEQRLAAVQKFNSENRYKKKGITVIPTKFGIAFETLFLNQGGALVHIYTDGSVLLTHGGVEMGQGVHTKMIQVASRILKVHPDKILITETATDKVPNATATAASTGSDLNGMAIMEACNKIMQRIKYIIDANPEGTWESWIKKAYFDRVSLSATGFYRTPDIGYDFATNSGTLYDYFTYGVACSEVIIDSLTGDHQVLRTDIVMDLGESLNPAIDIGQVEGGFIQGYGLFTMEEMIYSPTGIVYSRGPGVYKIPGFADIPQEFNVSLLKGSSNPRAVYSSKAVGEPPLFLSSSIFFAIKDAIKAARKDMNLHEYFRFDSPATAARIRMACIDHFTKKMDSKKLQMNSGRESGDSAEEDCSVNGDSYQRSNISNVLVFYVNGKEVVDDDVDPAWTLLYYLLGLVGTKLGCAEGGCGACTVMISNHVAANACLTPVCAMHGMAVTTVEGIGSTRTRLHPVQERIAKAHGSQCGFCTPGIVMSMYSLLRTKPLPTMEDMEVAFQGNLCRCTGYRPIIEGFKTFTEEWEQSQRLSEMKKDEKKVCAMGDACCKKAFTSEPTEVFSSKEFLPYDPTQEPIFPPKLQLSAEYDEQYLILKGKEITWYRPTCLRDILTLKQQYPKAKIVVGNTEVGVEVKFKHFVYPVLILPNQVKEMREITELDDAMKIGASTTLVEMEDAFKNQMKIKPEHKTRIFKGAVEILHWFAGKQIRNVAAIGGNIMTGSPISDMNPVLMAAGIKLNLCSLERGYRSVTMDHTFFTGYRRNIVAQDEILVSIEVPFTLPNQYFVAYKQAKRRDDDIAIVNLALNVFFEPGTSVIQKAVMAFGGMAPTTVLAKKTCEAIVGRKWNSELVESVTNLLIEELPLSGDAPGGMILYRRSLTISLFFKGFVYITKQLRENVPDVEPLPKELESAGEGFHYVPPKSSQYYQVVPSALNSTDLVGKPIVHVSAMKQAAGEAVYLDDMPKIIGELYLAFVLSTRAYAKILKIDPSQALSVKGVVAYYDANDIPDHNRYVGPVLHDEEVFVSKEVTSQGQIIGAVVANDQLTAQKAARMVKVEYEDLQPVIISIEDAIREKSFFAGSGKSIVRGDVDKAFAECDHVIEGEARMGGQEHFYLETHCSFAIPREEDEIEIFCSTQHPSEIQKLVAHALGVQINRINVRVKRLGGGFGGKESRGQLVALPVAFAAHRLRKPVRCMLDRDEDMMITGTRHPFLYKYKVGFNNDGLLQAIEIHIYNNAGYSLDLSMSVLERAMFHFENAYKVPNARVYGYACKTNLPSNTAFRGFGGPQGMFAAEQMIRHVADYLGRDVVEISEMNLYKEGDTTHYHQKLENCTLKRCWDECLALSNYKERIEDVKKFNKQHRYRKRGFAVIPTKFGIAFTALFLNQGGALVHIYTDGSVLLSHGGTEMGQGLHTKMIQVASRVLRVKPEKIHIAETATDKVPNTSATAASAGSDLNGMAVLNACKEIMSRIQYIIDANPEGTWEDWIKTAYFDRVSLSATGFYRTPGIGYNFANNTGTPFNYYTYGASCAEVEIDCLTGDHQVLRSDIVMDLGESLNPAIDIGQVEGGFIQGQGLFTMEEMIYSPTGTIFSRGPGVYKIPGFADIPLEFNVSLLKGATNPRAVYSSKAVGEPPLFLASSIFFAIKEAIKASREEMGIRGYFRLDSPATSARIRMACVDPLTKKIGDGDGKKAWNVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI32</accession>
    <name>A0A232FI32_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_007633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000187">
        <property type="protein sequence ID" value="OXU30180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI32"/>
    <dbReference type="STRING" id="543379.A0A232FI32"/>
    <dbReference type="OrthoDB" id="77368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03406">
        <property type="entry name" value="SPFH_like_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000009">
        <property type="entry name" value="Erlin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033294">
        <property type="entry name" value="Erlin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351:SF3">
        <property type="entry name" value="ERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15351">
        <property type="entry name" value="ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013302848" description="Band 7 domain-containing protein" evidence="11">
        <location>
            <begin position="17"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="12">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU30180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="333" mass="38120" checksum="7A57C112C980509D" modified="2017-10-25" version="1">MIDQNIIVMCFLVCLAVVFNFSLHRIEEGHVGVYFRGGALLPQVSSPGFHMMIPLLTTFRAVQVTLQTDEVKNVPCGTSGGVMIYFDRIEVVNILNANSVYNMVRNYTADYDRSLIFNKVHHELNQFCSVHTLHEVYIDLFDQIDENLKTALQRDLNEMAPGLSILAVRVTKPKIPETIRKNYELMEAEKTKLLISTQHQKVVEKDAETDRKKAIIEAEKEAQVAKIQYNQKIMEKESLQRMAAIEDEMHLAREKSRSDADYYQMARQAEANKLLLSKEYLELEKYKSLSKNAKVYYGQDIPKMFSLGGCSNDANLGSSINRVTSEKDENYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIF7</accession>
    <name>A0A232FIF7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_013486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000156">
        <property type="protein sequence ID" value="OXU30462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIF7"/>
    <dbReference type="STRING" id="543379.A0A232FIF7"/>
    <dbReference type="OrthoDB" id="10067025at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021019">
        <property type="entry name" value="Mediator_Med30_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11315">
        <property type="entry name" value="Med30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU30462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="279" mass="31366" checksum="AF4312B3516881A8" modified="2017-10-25" version="1">MAGQQHPFPTGFPNAQQNTMRNQFGGGQMVSGLMGPQQGMVSPQQFGGGVGAGVGPNALGMLNAQQVMAQQQPMQQQMQHQQQMHLQQQQQAALAQQNNQVVGTPTTPQIPVPQSQPPAPRPPTRDLNTASLCKLGQETVQEIVSRMQELFQTLKVIQPPNGTSQGQNLSNDKKLKVQEQLKTTTVLFKRLRVIYEKCNENCQLQGMEYTHIESLIPIKEEWDMKSDEKKASEAYRLACEEHKDAMEQLVLKNRQLKEIIDHLRRIISEINTMMSMRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK89</accession>
    <name>A0A232FK89_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000090">
        <property type="protein sequence ID" value="OXU31082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK89"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12920" checksum="89DEFB0FB853C937" modified="2017-10-25" version="1">MFSLQCMDEFYEHDKCNYYLIFKHLKSFRCSNKWYNLSIKGQKLVYFLLQNNLKKITLKAGGIVDLNLQQFAAVSICLKSEVNINRTLDFENINVLRYSYDVNEWLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKH2</accession>
    <name>A0A232FKH2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Ribokinase</fullName>
            <shortName evidence="13">RK</shortName>
            <ecNumber evidence="2 13">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_006477</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 13"/>
    <dbReference type="EMBL" id="NNAY01000080">
        <property type="protein sequence ID" value="OXU31165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKH2"/>
    <dbReference type="STRING" id="543379.A0A232FKH2"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000010">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="15">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU31165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="309" mass="32888" checksum="CBB7A87AB170F04E" modified="2017-10-25" version="1">MSNTIAVVGSCMIDFITYSSRLPKIGETLIGNKYEQGFGGKGANQCVTAARLGASTVFVTSLGSDSLGKEYLEKLKTENVDVTHVKLQNNIHSGIAQIIVTETGENVIVIVPGANALLSPKDVVEAKEKIQAASVLVCQFESSLEATLEALKLYKGHGISIVNGAPAVKSVHPDILKLADIFCVNETEAELMTGIDHLTLKNAQDAVDKLFSLGCNTVIITFGAQGAIHASQSQKKFVHTPVEVVKAVDTTGAGDAFIGALAYFLAYHKDLPLEESIKRANKIAAQSVLKSGTQTSLPYRKDIPATLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLE8</accession>
    <name>A0A232FLE8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000047">
        <property type="protein sequence ID" value="OXU31576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLE8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8717" checksum="6210825206BB391A" modified="2017-10-25" version="1">MKIRAKIVNRVYENWKYFEPFIVGDESLKITDRSTYKMHMSMNSTYGSKTEIIAFVRLYSVRISVSSTNFINPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLL0</accession>
    <name>A0A232FLL0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_016126</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000041">
        <property type="protein sequence ID" value="OXU31636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLL0"/>
    <dbReference type="STRING" id="543379.A0A232FLL0"/>
    <dbReference type="OrthoDB" id="7699693at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU31636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="514" mass="58507" checksum="79C0E79F7C82576A" modified="2017-10-25" version="1">MVRRCCVVTCRNSRSENCDERVSFFKVPSDQNLLDKWLKAVKERASAGDTILQRSSSICERHFRDEDIRREATLKDSFGNVIFQRPLIKFSLVKDAVPSIFEEDLEKSSIRKRRKRKAPKDPENSNDGAQPNFQGNFILSNDGNLNVNYSNILVTFNENQSNLVNFNVAPSNNSQSEVIPITVRNGAHNALSNLDNINGTFDATAYFVNGQVNSYNNGFDITSQNKDSQVSEKTGTGESNQPKIISIQYLKPQEHFTDLSNISKEQVQNHHSNFNGLNGPKEVTIIVPQEELMILNESNNYAHNNNTQKTVNHQVKNKNAKTPAPPKGGTLHYPLPESEAQLNIRAFDLIFHNSHKIKLPNAMWGYHKNCIDKDIIIFSKAKWFKSDVLIPPIYEKQVIFHESDNIKIYINNKFSPLEVRRPKDVQEMEVILKHVDETVVCSGGPNIGECDTAQCAQKDYAVNRWRHKLCPIIIGEAETICKFCSTINQVLRYPKKKRLPFGRRPPPDVIQEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLY9</accession>
    <name>A0A232FLY9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000032">
        <property type="protein sequence ID" value="OXU31761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLY9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="9267" checksum="59DA7CB744BABA81" modified="2017-10-25" version="1" fragment="single">MRYNQDYQEGPMVVLFVLFTNSIPSIYKSRIAFHGMLQRMGYSSWYEFLGNVCTDENLIRLANNFALDKRFCCFYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM03</accession>
    <name>A0A232FM03_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000037">
        <property type="protein sequence ID" value="OXU31692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM03"/>
    <dbReference type="STRING" id="543379.A0A232FM03"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055262">
        <property type="entry name" value="GGT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257643" description="Gamma-glutamyltransferase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="530"/>
            <end position="531"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="71553" checksum="7F60420FFEC25A0F" modified="2017-10-25" version="1">MSGTKASLRKCRWVIPIISLVLVCAFPTTSNPVPEQDEHICYKELGPNTQVLEKNGDLYVFKPSNETSGTYKKAAVASSSVRCADAGAKILKKGGSAVDAAIATLLCDGVVSLQSMGIGGGFLMTIWDAKEKKAHFLNAREYAPAAAHETIFTIANEDESVNGGKAIAVPGEIAGYWEAHQKFGILKWAELFEDAIKVCEEGSYVSAYNANNIQKAKEDLENLTYNFTKPLKDILMKPNNNNEFVDIGDRIRRQQLAETLRMIRDGGKDVFYNGKIADDLVSDIKQVGGIIEKKDFQDYTVEWKTPVSTTIKGKTLYSASTPGSGAVLAFILNVLEDSISTATNKSVMYQRITETLKWGYAEKNGIGDFIERNEYNNKTSKEECKVEPWYVKDLKNKGYYFVKRNNEIWDRDCLVSVTSKKLLSKEYANEIKTKIEDSKTYNDYKHYGVDSAGSIDEGTSHTSVYAEDGSAVSVTSTVNHGYGSKVLSEKTGIILNNEMNDYNYPGIDSFFGKPSEFNFVRKGSKLRPLSSMLPTVILNEDQTVRLVIGSAGGPKIISGVVEVIIKNLILGDDIRTSVDKQRINPNFWSMSLQIEPGFDPEVKTYLESIGHKTTIWLDILNTVAAIAVNKDSVTASGDFRRQAGTCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM26</accession>
    <name>A0A232FM26_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000030">
        <property type="protein sequence ID" value="OXU31801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM26"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="5377" checksum="7F63E02D9E2C31D3" modified="2017-10-25" version="1">MAMNGLECGQRKLLAPPPDDAPLANGSKAQRPMRCEVVARRTTTFGVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM51</accession>
    <name>A0A232FM51_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000035">
        <property type="protein sequence ID" value="OXU31725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM51"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047876">
        <property type="entry name" value="SHKBP1/KCTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Potassium channel tetramerisation-type BTB" evidence="2">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39064" checksum="AFC15746DF8DBF2B" modified="2017-10-25" version="1">MGVYCGMRLCDIVRFAKLTDVKDISTTGVGTFWGLGSLLTDAEGFDELLQLAEIGDLRNVDMLVIKTFMVEIIFYKAWQVRDENEVLFIDRDPKIFSVIFNYLRITDIDLESVNIRILKHGAQYYGMTLLVKRLMLCEDLSQFSCGDVLFYDILMQEPLSVSLSISDVSVHGRPPGAILTLLSRAETLLTLQPTANANNSPAQTESKIDISMETTLPYLTRLCERSELSFLLYPGVEIAPLYSKSLIRSGILKIVIVIPVIVIPLAQITKVLKEQVHPLVSIEPDASLYDAIKTLINNRIHRLPVIDPDTGNRSRQSIPRLNKCFERMRLTPSVWFRANDAKTGPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM93</accession>
    <name>A0A232FM93_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ionotropic receptor 75a N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000030">
        <property type="protein sequence ID" value="OXU31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM93"/>
    <dbReference type="STRING" id="543379.A0A232FM93"/>
    <dbReference type="OrthoDB" id="6424337at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="524" mass="60671" checksum="6C61307152F4D3C0" modified="2017-10-25" version="1">MRRDRNIHKMSSAFKCLALFVFIIIIFPLDQCKQNITDEFIIEYFRYRAPSTVVGFTCDQYENDVQLIKKFSDVKLQSLIWKLENRMELSSLAKALHHRLGVFIDLRCQFSENVKMAFNEATDHKMFDELYYWLILGSDLNESLSLINDNSFGVSTDFVLAIFEENQCILYDIYNPCKLRGGTLKTTRLGFWNESSGLNIVFELNKVRRWNLEGMAIRISGLVCKRCSLPFKKVETCPVVKNRPSNVPVLEYLQDPNYKHLDRLTRLGYAMWMHLADMFNFTVQIVFLKHITRFVHVYSLEFNETTVWNEGDENGPVMTSLMNGEIDASGTADALTIERLDLVKAVYPALPFRYFIIQYEMIIAKLLLKLTILLDFRTCFIFRSTSSDRISVRDIFLPLSSTVWYLTIAISVLSINALAFLSILSNRDIYENYLSSIIIHVGAFCQQGTEFSSNNLSGRIAILHILLFNLLLYNYYLASAVSNRLSEPITLINDSLHELRKTDFQYASEPMLDFDRHIKVDAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMQ5</accession>
    <name>A0A232FMQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000011">
        <property type="protein sequence ID" value="OXU32026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMQ5"/>
    <dbReference type="STRING" id="543379.A0A232FMQ5"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF405">
        <property type="entry name" value="PEROXISOMAL N(1)-ACETYL-SPERMINE_SPERMIDINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU32026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="509" mass="57717" checksum="722F8589B1A7611E" modified="2017-10-25" version="1">MNSGRPESFIETTKLVIVGAGIAGLGAALTLEKCNFKDYILIEAQSEIGGRICSVPWNDGWIERGAQFLHGRGSTLGKFAEEKGFLSDDEVAEGEGLYLREDGTEMDHELVREVDDIVKNIMEDCEKYATNNEIEYLDVEENIGKVLKTRFCKYLTMTNDPLSIRNAKEELFDWNVRFLAIDNACNSLNELSVKSWGKFKAVSGPEHNIFKTHYGSMVESIAGKLTQENIRLNSPVKKIEWNEQVNSHDSKTILVTLQDNKQILANCIIVTCSLGVLKETHNKLFSPILPVRLRGAIESMGFGMINKVFLDFDEPWWEPGTKGFQFLWRTETDNCTNNQNKNKLPLWTRDLTGFDVLPGHRSVLLGWIGRKGARIIESLSEQQIIRDCSDLFKYFLKKNEVPEARKCLRSRWSSNEFIRGGYSHITKKCDVIGVSPATLAEPIWGTVSSHQKDERLPILMLAGEATHENYYSTTHGAYDTGVKQAQTFLQYHVTKYNTQVFLSVVNLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNS3</accession>
    <name>A0A232FNS3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNS3"/>
    <dbReference type="OrthoDB" id="7696379at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="300" mass="35060" checksum="65EA502209C36C07" modified="2017-10-25" version="1">MSEYLIKVTSTGRIGSMPDMSGRYKAVSNSNEVPRSENNFDTVNVNSLIAKEIDKRFKERDNAKTSLESRNMKRKIELGSNVDESVLKQPKYDFRERLIGRLEINYYSKVCDIQEPKKILEKLKTSKLSEANLTTMKLRERLYSIKYNPSKERASAFWNRFEDIVRMYNGLPDVKSLTDDELVIEGVEAVIIIAVVQNVRMKVRTIRMLKGVDKRGRGNRNRNYQGEKQQKGNNKQDKDQQQNKGILNINEIQRMNEETEELVERENETENERENEFEREKEKEIVNSNLGNCSDFDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED13</accession>
    <name>A0A232ED13_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01009982">
        <property type="protein sequence ID" value="OXU16227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED13"/>
    <dbReference type="STRING" id="543379.A0A232ED13"/>
    <dbReference type="OrthoDB" id="6740702at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="810" mass="91847" checksum="FD2A7B27388BD146" modified="2017-10-25" version="1" fragment="single">MDQCDKTSVQSNLKTLENLLADISTDEDDDAYTTSSQNVEATSSGEGEEGGETEEGEEREEEDAAQAEDAVVDVQFVPAEMVVGADDAREEEMQAEEEEESEAETSEAAEGEHEHFYVSREEADDARQQAAAGYLQPNEVGEGGDGGDRAIESEDPPVNEDPQHMSNVDRLLSICREPIAAVNNILQRLMERAADESENMVEYANHPCVERREQILEFLSRPIEPEEMRYTRRSAEGVVTEHFFNQRNPRDRQINELIRRGLEGFSKYPNSLKQDIARIMYVRRAQEIRWFFNACKDNENSVLLSTENLPELFHRLGQKYIDSDASSITVLPLSTSSSSYSNTTVESADYEADESDECMQVGGGFESLENSSQDGFSDNEQDEEAQAEEEEVSDTEDHTDSQGGRDQNMDVDSEQNEDIQPPGNRFIIFQNNSHYISKYKLEGRRLILKIKPPPEDGSINPIVWLELVIRDIYAYIISLCNDNDMIGVSVRSLNFARGPGGLSLRLVNNFFYNDLWNLISGLAQSNEDFQIDESFIMTLTLVNVPNGGRGGKKNINVDTLGQRSIVTIRNIDNLCLPRALIVGESFITYKKSATNEAREIWNIVRDSRRSMQKERANLLTISANVVIPEIGCGIREIEAYQEYYVEKNIAIVIYDSLSFGSGEPAFYDGRPLLNSNNFDVIYLLYDAGRRHFDTILNLSGAARSHFFCEHCNKNYRFIDEHRCSAKCHRCFCTPACNTDIDVIKCFQCNREFFGEICFDRHKTAGSYKKNNKKVCDVVRVCTMCCKRINIFKSKHECGVNWCNLCRKKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED24</accession>
    <name>A0A232ED24_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01009046">
        <property type="protein sequence ID" value="OXU16246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED24"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="10460" checksum="93BEC050F938D58B" modified="2017-10-25" version="1">MRDFEEGMRKSAHKAFPDAQKIGESLQYSWDKKKQKLTTVLLPAEQRKGEENDVTVLWYDKEFLLQFDETKLGMDRTYNSRPNIYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDB3</accession>
    <name>A0A232EDB3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007296">
        <property type="protein sequence ID" value="OXU16332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDB3"/>
    <dbReference type="OrthoDB" id="7701400at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="12757" checksum="32420BE894C77E6D" modified="2017-10-25" version="1">MLEGHTFNTLEDLKKHLKDSLAPNESYGYYLNEIQSATIRQFYGRLNALINSAVTVVKEGLTAAQAAVDQGPHLELLTLESFVNGLPDGWRTGLVDSAPQTLQAPTTSPTIMRKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDG0</accession>
    <name>A0A232EDG0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006462">
        <property type="protein sequence ID" value="OXU16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDG0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7317" checksum="DEAAB37CAAB76056" modified="2017-10-25" version="1">MNNNECILVLFSNQQKAVTGYLVDSGITSLSLVKYFLYRPLFRAFGIFLRYTRKVLASEYTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDV2</accession>
    <name>A0A232EDV2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005840">
        <property type="protein sequence ID" value="OXU16530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDV2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="10418" checksum="00977A66DE179263" modified="2017-10-25" version="1">MLQQYKPKLYKKYRKVGYKLDSEIPEQHRRYDIVNNKVYLSENMRVGDLITVLWTKKRIALKSLDLSKLKKKNLERSLYNYTHLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE59</accession>
    <name>A0A232EE59_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005547">
        <property type="protein sequence ID" value="OXU16640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE59"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="113" mass="12266" checksum="B043CE340F4CE193" modified="2017-10-25" version="1">MAVQFWGPGVEEVPEIEMYESDPESGDDGYASEVGSVGEADEAVDAGPDPLYPCHGIAGSSVYVDGRCAICRQPSALPAAMDVRRVSAGVQVGAYFILYIFFLFYLLIRYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EET6</accession>
    <name>A0A232EET6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005221">
        <property type="protein sequence ID" value="OXU16870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EET6"/>
    <dbReference type="OrthoDB" id="7536850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12804" checksum="1FE61EF87C55DD25" modified="2017-10-25" version="1">MKRLLQCRYPKQVSLMALLTRSLMGGFRFNACGGRLYYFFSIRFNMELPLFWWRHGIPVARWRSTSIGLSYIIIDGEWYRYVFINVHCPTEDKEEEAKDLYYETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFI1</accession>
    <name>A0A232EFI1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005013">
        <property type="protein sequence ID" value="OXU17111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFI1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="14026" checksum="D21DB9D7495CD20D" modified="2017-10-25" version="1">MGLILRCRTTFKTRSKHLRHIITNTTSSQHQRTSCDPWFISVDLKVGTSQLLCVCRSATTESSDIGTMIHRKFIISFVAALANYGESRNEDYQNCSSDWQRTLGAQDHYAENGALDNKSPRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFX7</accession>
    <name>A0A232EFX7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004911">
        <property type="protein sequence ID" value="OXU17253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFX7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="158" mass="18135" checksum="7370B2694DDD280F" modified="2017-10-25" version="1">MISDKEKAENQNVIIIKGSVDEKGSDVKKVVEKFLDEKLETKVDIKSAWIRGKVIVARINSFEEKEKILSSKLLKYSIKIRVPVSFFLFLMKETRGYSAWVKTKKDMGFIVRIGFGKWEDRVSAKSHMADDKKKSDDKKKLPEQQEELDFAGASANFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH26</accession>
    <name>A0A232EH26_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004614">
        <property type="protein sequence ID" value="OXU17659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH26"/>
    <dbReference type="OrthoDB" id="6740702at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="17174" checksum="BF80405D914046D9" modified="2017-10-25" version="1">MLLNTVQSANDSNITDRLSINCAIVESVAGSSRVKLTEETVNKRSIFGMRNYHNLCLPRSLVAAYAYAVRCQIRTGSRHNYWNLIRQNRGRVPKRAAENKICHRHTVVFDQSIINQSLILLELVSVINIVYPVIKVISSLKIIDVLINVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHF7</accession>
    <name>A0A232EHF7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004530">
        <property type="protein sequence ID" value="OXU17761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHF7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="185" mass="22837" checksum="3335E844BBEA9F3C" modified="2017-10-25" version="1">MGIWMIEKETEEKKEKRSGEKSSRLRTRRLENLKKIERLEKKSTDIDTQERKMKETTVEEVEEESERDKKERKRHKKSLFIRKVLYWRQIENEWWTENMLKIDFDEAKGRKKLRKWRRVAKEENCYVLDEWLSLKEREDRFHLVKIARELDEKKTEKGEKIKSRKKGELKKISEKEADEEPVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIC8</accession>
    <name>A0A232EIC8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004286">
        <property type="protein sequence ID" value="OXU18103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIC8"/>
    <dbReference type="OrthoDB" id="7693528at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="418" mass="47719" checksum="B436479724B62E73" modified="2017-10-25" version="1">MACDHNKICPSIQLEVSCTKCDDVKKSNPTAANKCQPFLANTIERYADRQEDLDERHRQLKDKISTMEKLLPALIACGMCNKSSDEKNQACESSNAALNQVREMMRKLSPLPDPADELVAELATCVEQLNRETAELHDKIINADIQLEESCMELESLGQANRELEEQIRHLEAQLNSQTSLQTISSEDRICLSRIRKLAEDEIKMKSNIRELEEREKVLCCQIEKIFGSSDKPLCEAARGQKHHAHRPKSRKKKHCNTLETSTESLFKKDKKCDKSKCDTIISGNIPVMCCCLKDKVGCSYNFARTCEYLSQRKIQMPKKSKKSISSKLCNCNLSAKEKQQKKNYEPTDSRRCTPDVSHLTHRNALVKLQKQSPCMQQSVANFDEFVLLLTHDRAIQRINLTCSLDKPSIYDQKYEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIV3</accession>
    <name>A0A232EIV3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004156">
        <property type="protein sequence ID" value="OXU18275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIV3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="200" mass="23368" checksum="4A5F00008B0FA6E9" modified="2017-10-25" version="1">MTYSIENQPMLQSTPKIIRLPVPSYTTHEIPAKKPLEFSTRLKLMKEIAGSLASIGSTATSKNFEEKLNTLRHIESAWRQNKSVKFITDDDLSNFSNLSIVDKDVEEDHEKSIILPTPVKIRGRPSKITKKRYTTKDYLKYFNQIVKQKRKKNIFICDLCFQEADDMTIQCDICFMWYHFICVKMNLCCSMIFHITIKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK36</accession>
    <name>A0A232EK36_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003882">
        <property type="protein sequence ID" value="OXU18720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK36"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12864" checksum="8C154BEE9342FA52" modified="2017-10-25" version="1">MNNLTSENKRAIEQIANKIINTWKLKTENKQIIRTTTTEDKVFKSTLGNAEKQKKQLMLAENCENCDVPKPSITKHIHFVKQEQKVDDDSIKHIKEIKKQSNQYSLRLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK55</accession>
    <name>A0A232EK55_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003860">
        <property type="protein sequence ID" value="OXU18746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK55"/>
    <dbReference type="OrthoDB" id="10600644at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012240678" evidence="1">
        <location>
            <begin position="18"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17064" checksum="2F9A3604CF195D5A" modified="2017-10-25" version="1">MKTIVFTLCMMIVAVRCSPRPGGRGGGSMFNRESVKKCMSEMDIKREDIKTLKQNNDPKLSCLNACAMTKEEIMDEAGNIDADKLIKTTLELVQKKKPDINVEELETAMRSCVEKAKEVEDKCMKAKTLVVCSYEYWKANVKGNPSSAGGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK57</accession>
    <name>A0A232EK57_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_006978</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01003892">
        <property type="protein sequence ID" value="OXU18708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK57"/>
    <dbReference type="STRING" id="543379.A0A232EK57"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17951">
        <property type="entry name" value="DEADc_DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000449">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044113">
        <property type="entry name" value="DEADc_DDX41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="210"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="405"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU18708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="620" mass="69676" checksum="A76FC957CA258982" modified="2017-10-25" version="1">MDVPVKRYRRDDEKEEKDELESDDDYVPYVPVKIRKKQQLIKLGRLGQIKEDGTHGTGKSSSENERDEGDDEDIQVWGRKSNISLLDQHTELKKLAEAKKESAMEKQLKEEEKILESVAENKALMGVAELAKGIEYTDPIKTSWRPPRTILTMDNVRHERIRRKFGITVEGEDVPPPLRSFKEMKFHKGILLGLEQKGITKPTPIQVQGIPAVLSGRDIIGIAFTGSGKTLVFVLPLIMFCLEQEVALPFGRNEGPYGLIICPSRELAKQTYDIIQHYTNSLRHHHCPEIRCCLAIGGVPVSESLDVISRGVHIMVATPGRLMDMLDKKMVKLSVCRYLCMDEADRMIDMGFEEDVRTIFSFFEGQRQSLLFSATMPKKIQNFARSALVKPVTINVGRAGAASMNVIQEVEYVKQEAKIVYLLECLKKTPPPVLIFAEKKQDVDAIHEYLLLKGVEAVAIHGGKDQEERSRSVEAFRAGKKDVLVATDVASKGLDFANIQHVINYDMPDDVENYVHRIGRTGRSGHTGTATTFINKANDESVLLDLKHLLREAKQKIPAFLLELCSENEKYLNVGDEQGCSYCGGLGHRITECPKLEAIQNKQASNIGRRDYLASNAADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKL0</accession>
    <name>A0A232EKL0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003753">
        <property type="protein sequence ID" value="OXU18899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKL0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="249" mass="29261" checksum="3CA0675ABBDC506B" modified="2017-10-25" version="1">MRGENYIHMNSTEDHYSIFVLDYYQDETGTKLCQECHNKKHLKTHKKEQYLLPPNNKCRDCKTNIIRTAKCALDALELLKMYEEMLNGLKAMKKIDINLIQYPINNKSGEKQVEPPMSEMQGTRSEIYQQISDKRNNHCYHCYIKGNKKKQEYLRRVTYQFNTRANNTKTCSGCGQRKLPKRIKFFDIIQLLPVVRLTRMPGKHESINITITEEINSVSLIDIEKTTNDFTTDLPIIVNQEKYIDSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKX0</accession>
    <name>A0A232EKX0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003680">
        <property type="protein sequence ID" value="OXU19009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EKX0"/>
    <dbReference type="OrthoDB" id="7700068at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="435"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="723"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="616"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="910" mass="106706" checksum="18523FB3B10C3816" modified="2017-10-25" version="1">MADGAGKTTSENNTRRRGRPPKEEKENIQTNEMKNYLIYINKQGDGQSKGEKIKESEAEDRKDNEKAYDTRRDDQVEEVEEKTPGKEERESHLPTQQKGDGEDNGPTDGEGEEKKESLEEESTKGTREATHGDDGKREDAKLDIRLLETKETENKLKGVVERLNKETDKNRDLENEIEKMPEVLEEQEIEWEIKEIIKTNLELDIYIRRVRSIGGGILLDLESFKNKIELMKRKKKLKGKNIWIEDDHTPREQEVQKWLEKLEESERKRGLEVRLGYMKIKVDGRWYFWNEREGKLENETEIKEIIKTNLEMDIYIRRVRAIGGGILLELESFKNKIELMKRKQMLKGKNIWIEDDLTPREQEVQKWLEKLKESERKRGLEVRLGYMKIKVDGRWYFWNEREGKLENETVLFWKEMGKEGQRREDDQINNGEKMNLINCYNNVGMSKIGKDLEEIVQEGVNRGVRVVLTGDFNARIGELQSEEDQEGKKLLKICDEIGLKIRNGAAKGDEEGRQTYTGEGTGSVIDLVLEIETEKESIIEEMEVIKRIESDHLPIVFLIRRRERDRGTVEEEEQEVIRKLKWKERRGVDYKQIMRERWDESESKKGYSQEKWNNLKKEIKETADMLNLRVDTEEKRKKSIENLREVKXETWLERERERRILKTLDQRYRWETKTAERESNRGRAKGGILVGIKQGLAKNVEIKEWKYGISIQNIDIGEGEKMNLINCYNNVGMSKIGKDLEEIVQKGVNRGERVVLTGDINARIGELQSEEDQGGGTKRESKDKTLNAEGKKLLKICDEIELKIRNGATKGGEEGRQTYTEEGTGSVIGLVLEIETEKESIIEEMEVIKRIESDHLPIEKWNNLKKEIEIREIDSRYVKFDTGVDTEEKRKKSIENFRGVKEQKKRYLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL90</accession>
    <name>A0A232EL90_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003608">
        <property type="protein sequence ID" value="OXU19115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL90"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12685" checksum="97CF993444C0C200" modified="2017-10-25" version="1">MVSKDSLKHNHFDNSFCSSTSIFSLLTTPSNTNTSVESQDYEADGSDVSIQVGRGQRKIKNLSSNNDDLSDYEQEDNQPSEKDEKEEEEEISEEDEERSENRQQHRPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM12</accession>
    <name>A0A232EM12_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_008624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003445">
        <property type="protein sequence ID" value="OXU19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM12"/>
    <dbReference type="STRING" id="543379.A0A232EM12"/>
    <dbReference type="OrthoDB" id="7548151at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30760" checksum="149A73F71D840312" modified="2017-10-25" version="1">MDKETSMYMAAALLSFTTLPIAPMVLNFLKPLNESRPKIFILGGEFFTDRLEHYGKIYLFDCVCCSITAIIICAVDSMYAVCIEHCLGLFAIIKFRLQMSTKFINNKSIESKQKHEDISYELIVQTIQLHKKIIMLHIIASSYSSSFLILMGLNMIILSFESVLILIKLNNIIEVVRFGFILLGIVIHLFYISWPGQKLIDFSVGLFQDAYVNEWYESSIKAQKLLGFMTLRCIRPCQITAGGIYVINFSNFASIVKTSLSYMTLFASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM88</accession>
    <name>A0A232EM88_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_002163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003401">
        <property type="protein sequence ID" value="OXU19466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM88"/>
    <dbReference type="STRING" id="543379.A0A232EM88"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001385">
        <property type="entry name" value="zinc finger protein 774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="434"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU19466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="613" mass="66472" checksum="715DA0C70D6BF91F" modified="2017-10-25" version="1">MDLTEAYAPSQNRRGGTVTEEKTTDYFDFVVSPPPHCTNADGTVDGDNFLQHTDCRTINFLEDADLNRDSFIANVKEANNNTIQLPALPPVSTITGHINRNCGYPLLEDLSYYTNNNWNTSPATSNDHHSGLLNNQRRDSPLGDMALQQHRDCSSDDRQNTDGAIYTLTVLNSEANSIDGLECCKSSPSGTTSDGWTLRNNQLDLDAILNMESSVNISDPNDRDNERGQDVVSVNGNVVDRYTAIAGTQYTTDDQTGPFGVTIKTEPFGVTVKAEHGDNNNDWKLSDRNNLQETVTVSESAAESLLRNALQGKLYSTTTSLTGATRLLGDGSTSGQPNQDDTMQTCTDELLLSQLDVDGTYRTGDYDKLKNIANEVVESYCNLEPVCNVQATTVMYTLDPASGSLGTITLPADLAQVGTVTVVTTAPPQQDVLHQDTRHTEQQQPTVTARTTTATSQLQLPNNTTTTGRSTKAPKKYVRRANRNTANAAGNGGAGATSQGGAGATGSPGAVQQRKERSLHYCSICSKGFKDKYSVNVHIRTHTGEKPFACSLCGKSFRQKAHLAKHYQTHVQVDGIHVEGMQVEGVPVEQQQLEHQQQIIEMPADSQACTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMT8</accession>
    <name>A0A232EMT8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003290">
        <property type="protein sequence ID" value="OXU19674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMT8"/>
    <dbReference type="OrthoDB" id="7700397at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="229" mass="25668" checksum="9400ECE3847856FE" modified="2017-10-25" version="1">MAPRVCWLRPEDHLCSMSLAKVKKLTTPMKAKGKASSGKSSKLPSSSFTGYSLAKKRKMFTVMKQGNSESVTKWHDKIKELASLCKFGDDLEDKMKDKFIKASLSHFLSESRIIGLKAGPIHDGVQEFTGSMDELLEAAKNLESNYNKQAFGSDFQPSSSEDSGNSEADVDFEKDKKNYREVHAYDCPCIYCDIIRCNKSRKCYDPNNSHPKKLILVSTQMAVKSNQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN95</accession>
    <name>A0A232EN95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003203">
        <property type="protein sequence ID" value="OXU19808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN95"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="123" mass="14702" checksum="8C39D1824175EE0F" modified="2017-10-25" version="1">MFYLNCLCKKKPHSIILLDKHVSEIINKLRLYDVVKNLKMERLHEKVNFLLEIMTKVWRDCQMVIKNFRDMCLVDKAKTILKWLEFAKAFIADVLYGRNSIDIDQIKKISSISESFRDDEKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENE2</accession>
    <name>A0A232ENE2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003189">
        <property type="protein sequence ID" value="OXU19841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENE2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="7800" checksum="C956D1F563654D50" modified="2017-10-25" version="1">MPGCPNASRYAAVSEDISLPISWRIWAKSITSGKNPVASKIVNRYSDIFEIPEYKYSNDKVFWGTWCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENW9</accession>
    <name>A0A232ENW9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003050">
        <property type="protein sequence ID" value="OXU20055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENW9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="53" mass="6100" checksum="99793B6E41BDF627" modified="2017-10-25" version="1" fragment="single">VTSFVYNFIAQTAKICKSRLSEIKVVLLCTVKLAHERSECDKHGAKKDYFSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPW0</accession>
    <name>A0A232EPW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_016511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002882">
        <property type="protein sequence ID" value="OXU20390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EPW0"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="427" mass="46848" checksum="01BBA45A7C0B7584" modified="2017-10-25" version="1">MDRGEEEYRRSPVLIPVLLSAIAIPLSMLFWTINVVYSFLSPSVEQHQSDVTMDRSKEEYRRSPVLIPVQLSAIAIPLSMLFWTINVVYFFLSPSVEQNQSDAVXLSAIAIPLSMLFWTINVVYSFLSPSVEQHQSDGYIVISPWRWLVAVLLPILCSLWGLKRKAIVMSGAILGFMMGFILTLTSLSHVACLIAFFFTSSKATKFRIEKKKTIEELKEGGQRNWIQVLCNGGMATQLAILYLLDVGCGERPIDFDKDYRSSWLSIGIMGATACCNGDTWASEIGTVVGKSDPFLITSRKRVPRGTNGAVSWVGLLVSALGGLVVGLFHYLTVLYAVDSAVLEVAAPQWPIIVLGGVGGLLGSIVDSILGATLQYSGMNEKGMIVERPGKGVKHICGRQILDNHSVNLLSSIIIALTLPRIANLVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ38</accession>
    <name>A0A232EQ38_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002852">
        <property type="protein sequence ID" value="OXU20442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ38"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13175" checksum="9751360553D71553" modified="2017-10-25" version="1">MVIKDDKKDSEPIMNRLLACVVTSWTSLQAANGLQPDVAEYLQVKMFTVSKIGLDGVVVEDGCVKKAVEFKCLITCKENPIFDYQQKKCNVNYLYFVQDEVKLKESFLYYTQCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ66</accession>
    <name>A0A232EQ66_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002819">
        <property type="protein sequence ID" value="OXU20504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ66"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="83" mass="9418" checksum="91ACD0574C3B1EF3" modified="2017-10-25" version="1">MNVRLAAQTVYLGTSDGTPVIDCARKTGFVALNYKQKEEKKYLIGNRTPKKKHLAMCLKPHDHLRIQIAINSKWLMIIIPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQC6</accession>
    <name>A0A232EQC6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002786">
        <property type="protein sequence ID" value="OXU20563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQC6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8465" checksum="7C7881FB71A2B01C" modified="2017-10-25" version="1">MVLFYTAQLAPKRSEGAKGRVKLNHLSQEYPQTAKIRMSRLFVTKVVLISTVRLGHEHSQCDKHGAKKDCFSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQJ6</accession>
    <name>A0A232EQJ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002747">
        <property type="protein sequence ID" value="OXU20633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQJ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172517" evidence="3">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="198" mass="23803" checksum="2E4CD3850A9F0850" modified="2017-10-25" version="1">MGASYLVILLLISCRVNSNGDYGRDSAINYVTIEEALQRRIDAIKDKIDVERRERERRIQENNEKFDELQRRFAVEDVVEVKDADQDTRIERGREDNEVIQESKKVKDEAAGQQPIFLFQSEAQPSDKRRIIRRRRVARRFRGSPSRFVRRRRRRHSRSPRRRRRRRPRRNKSLTSAYAENFARTDYKNGPLSRFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERD2</accession>
    <name>A0A232ERD2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] 1 subunit C2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFC2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002641">
        <property type="protein sequence ID" value="OXU20882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERD2"/>
    <dbReference type="STRING" id="543379.A0A232ERD2"/>
    <dbReference type="OrthoDB" id="6329847at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009423">
        <property type="entry name" value="NDUC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13099:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13099">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06374">
        <property type="entry name" value="NDUF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14044" checksum="1BDFBDA2365323D0" modified="2017-10-25" version="1">MTTENPDIQWALDLLTPDPNYQENFISKNYPWIVCPFITVGGNAYVTYLQGRPWYSGIRRYALAIGAGIIMAKVLKDAKYHREAERDAVMRHYIKLHPEDFPPPVRKTFNEELRDWVACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERU3</accession>
    <name>A0A232ERU3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002555">
        <property type="protein sequence ID" value="OXU21057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERU3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008730" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="7816" checksum="A184B7213FD00860" modified="2017-10-25" version="1">MCQALTFVGLLQLLDSSQPVFWCYYLSGKTVLALIIRGDHSKCLPYTCYGLNSSLPPLWHNTICLAIIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERW0</accession>
    <name>A0A232ERW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_013188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002545">
        <property type="protein sequence ID" value="OXU21090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERW0"/>
    <dbReference type="OrthoDB" id="411535at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026721">
        <property type="entry name" value="TMEM18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22593">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22593:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14770">
        <property type="entry name" value="TMEM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="161" mass="18481" checksum="8FCE75EFF8DEB3E5" modified="2017-10-25" version="1">MSDRQFVATDTIDGVWPFLQSIDWRDPWLALLLTFHIAVTMTALMTRNHANFQILLFLVLLLLVYFSESINEVAATNWMVFSRQQYFDSKGLFISIVFSVPILMNCMIMVASWLYQSSQLMTSLKRAQLRQQAKNRLTTTPTTDASNGTSNISSRTEKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES47</accession>
    <name>A0A232ES47_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002510">
        <property type="protein sequence ID" value="OXU21162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES47"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="52" mass="5889" checksum="5C2A35181DD50059" modified="2017-10-25" version="1">MPACMLASRDRKMPTFCFRSCRCHTASTHGRHSDKVSCRRNVSTRAAKMSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES60</accession>
    <name>A0A232ES60_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_011473</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002491">
        <property type="protein sequence ID" value="OXU21195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES60"/>
    <dbReference type="STRING" id="543379.A0A232ES60"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000001">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="325"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="67"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="743"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU21195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="796" mass="88238" checksum="A223DA7C7B02AC69" modified="2017-10-25" version="1">MAHQLLSSASKLEKFLLSRLDHLQTWRKLSLLRNGPRISAIEQVQQQWRLLCNKPPKGFEKYFKQGQKTKEAPKEAEGPAKDSKSSQSAEAPSSKSPGSSSSGRKKDFTYGFYPGKNMGGEGGGPFQGNDKWLTLGAVGALGIIGVLMFSEGGKEITWREFVYGYLNKGTVEKLEVINKKWVRVRLLPGTSTDGTLWFNIGSSDTFERNLENAQLELNIEPQNHIPVVYKNEMESGHLVSYLPTIITIGLLLYFTRSTASMFSKGGRGKGLFGNVTSSTAKLINPNEIGVRFKDVAGCEEAKIEIMEFVNFLKNPQQYINLGAKIPKGAILTGPPGTGKTLLAKATAGEADVPFLTVSGSEFLEMFVGVGPSRVRDMFAQARKHAPCILFIDEIDAVGRKRGGKSFGSHSEQENTLNQLLVEMDGFNTTTNVVVLAATNRIDILDKALLRPGRFDRQIYVPAPDIKGRASIFKVHLQNLKTNLDKIELSRKMAALTPGFTGADIANVCNEAALIAARDKRESIIMKNFEQAIERVVAGMEKKTNVLQPEEKKTVAYHEAGHAVAGWFLQHADPLLKVSIIPRGKGLGYAQYLPREQYLYTKEQLFDRMCMTLGGRVSEEIFFHRITTGAQDDLQKVTQSAYAQVVHYGMNEKVGTVSFEMPQPGDMVLDKPYSESTAQLIDQEVRIMIDTAHKHTTALLTKHKADVNKVAERLLKQEILSRDDMIELLGKRPFPEKSTYEEFVEGTGSFEEDTTLPEGLKEWNKARDSSDTKPDGSSTEPPISPSDPPKNQPEQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESZ4</accession>
    <name>A0A232ESZ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002358">
        <property type="protein sequence ID" value="OXU21475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESZ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7204" checksum="321EED1B1D73213B" modified="2017-10-25" version="1">MRATAMSEPEWQYDTSGIASVLPSTICRIILMTVYVTLLQTIVFDLLNDDSATVCSLLNRYVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET24</accession>
    <name>A0A232ET24_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_009790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATG13 family. Metazoan subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002343">
        <property type="protein sequence ID" value="OXU21509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET24"/>
    <dbReference type="STRING" id="543379.A0A232ET24"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="103"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="423" mass="47107" checksum="0085075D6ABA7E0C" modified="2017-10-25" version="1">MWILLPPDEMSSLKLSMQDKRDLEKFTRFLALKAAQIIVQSRTGQKVCTKCKPNSSGTDWFNLAIEDEPDVAAEAKKVLCAEIISSTIPLCIEISLRTVEGDTMVLETWSLGVLPEQSDHTVRVTYTVYNRMGILLKSLLSVSRITPAYKLSRRQGPDSFKIYYRMYMGEPQLHSLGDNYKHVRVGQLCTPVGMIHLSVSYRTKMMISPTQTGRDSIMLKSDHFHSDLSPRHARYQQNEDGSKSLSDTIKVGAFVVNKQVAISEEDSHSDIPFSSLLTPRQTSSPTPATTEVSNAAQNNTTATTASAGAIDTSNGNERPANENTTPKCNSRNESRRSSCSMTSANDDFIMVDLKTPFAATNTNSDLGTFYRECQSAPQLQAFMEEQTLAEQVGDLTKQLEAFETNMHHYEDLLNSLCKSENNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETR9</accession>
    <name>A0A232ETR9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002238">
        <property type="protein sequence ID" value="OXU21753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ETR9"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000084">
        <property type="entry name" value="paired box protein Pax-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF16">
        <property type="entry name" value="PAIRED BOX POX-MESO PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="45"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="368" mass="40228" checksum="CF42A794E48C5B7A" modified="2017-10-25" version="1">MDPILLESNQQQQQHHNPHQQQQQQQQQSQQQQQQQQHQQQQQQQYGEVNQLGGVFVNGRPLPNAVRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVQYIKQLKHKDPGIFAWEIRDRLLSDGVCDKYNVPSVSSISRILRNKVGAAVTAAAAAAVAAAVIHHHPHHPXXXXXXXXXPPPPPHHHHHHQGSVEAPQQDASAPNAAGSFRRFLPIEEAALPSSPASSTCKQPSNPSPSPPPTSTPTSTSTTSLQWPSSHTVHDILSGAIPGFVADNLVQRSNGCNNNSHQLDQHHRQQQYYASTLYHHHHHLGHQPTATGNAGGHMQIVAAGNESFHAACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUI0</accession>
    <name>A0A232EUI0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002137">
        <property type="protein sequence ID" value="OXU21967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUI0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="151" mass="17117" checksum="6696DCDA38923A30" modified="2017-10-25" version="1">MEQSSDIVEPRLLNILPNMLLSTTYACHQGSFRPVDKLSTATLSFKSIKFDVASWNVFKNYFDLINTYFQDAYRFQDEEDEDEVNIASAALAESGFATCGNDATPVAGKYEPPRAKKQNTSRIQFAICMQKVTFDELKIVLPCVDERLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUM0</accession>
    <name>A0A232EUM0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01002109">
        <property type="protein sequence ID" value="OXU22053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUM0"/>
    <dbReference type="STRING" id="543379.A0A232EUM0"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="717" mass="81125" checksum="DBF4976F8D6C2DBB" modified="2017-10-25" version="1">MFSRNYQNPKEKLANVLPIFEPQSVDTWIGKVEELRIVNGWNEDTTLFLAASRLQGKTKDWHESGGKRVTSWTEWKEKLRQATKSLEEDRIDEAEESKENVLTEENNKGRAIHKEEKGRSSHTPLRPINNQQLSSTKTPKLPRVQLSIGLKSKNVDDPRFREVQVNGRQLLGLIDLASDVVTIRRREAVNLDIPIRSVSEKRVDLLGYDGSIVRLLGICEIGLQVDLAKEATVQAYVVPNEAQESPIVVGSVYLDRPGVTVLRRNGLVRVLDSTALEIKGLEEEMKNKPVALKERSANGKEEQDRRTSEKMVHLRRKILSFGGLLNQLQPNVRWSSSLKIRDKEAVQPERTFKYSDMSVRLAAPHQLQPKPNVSDLAFGKYFTDHMLKVFYYEALGGWQMPEITPFENLVLHPAAKVLHYAIELFEGMKAYRGVDGKIRVFRPDMNMDRMNASAVRSGLPTFNGMELIKCINRLISIDQEWVPHSEASSLYIRPTLIGIDPTLGVATSDSAMLYVILSPVGSYFKSKESLRGVSLLADPRYTRAWPGGCGDRKMGSNYAPTIHVQKEATEKGLQQVLWLYGDDHQLTEAGTMNIFLFCINDQGEKELITPPLSGLILPGITRNSILAMTKEWNQFKVTERTITMTEVRHLLSENRCLELFGAGTACIVSPVSYIEYMGQGLHIPTLDHAEPVHRLIHKQLTEIQYGYVDHPWAMPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUU5</accession>
    <name>A0A232EUU5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002090">
        <property type="protein sequence ID" value="OXU22108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUU5"/>
    <dbReference type="STRING" id="543379.A0A232EUU5"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="223" mass="26200" checksum="EAFC409B663ED966" modified="2017-10-25" version="1">MVNGSFVEWFAKLGESVETVEKLPSPRYIKTHLPLDLLPRQLLEKKPKMIYIARNPKDMCVSFYHYCRLFHDLSCSFEEFAELMVADDAPPGPFWSHVLPFWERRHQDNILFLTYEEMKKDQEGAIRKTAKFLKKKLTDEQVAQLSDHLSFPKMAANPSVNYEQVLAQKNVCPSDPNTKFIRKGKVGDWRHYMSEDLSRKFDEWTERNLKGTGLKFVTDDFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVG4</accession>
    <name>A0A232EVG4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001995">
        <property type="protein sequence ID" value="OXU22353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVG4"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47734" checksum="640C0ACED1690B32" modified="2017-10-25" version="1">MPAQLSKFAIRASCKEYAHPWSDSCISTTAGLGLQAVQDCLRIYSTLYFVNYASDKGKGSNIERLETDLYKYHTVNCISVMECFCLFHVYLHFSATEALFRMAVSRGYISGIPHGEVFIFAAGLATLLYFFRSKNNTDSIFRVLRLGLGPYEEKGYQQRNDSQAAQPTSSYAKNDTNRRRKPSNSILKLIWEALRVYKQLIDKVKTLGGKHSSCPHPNSCVHYVLSGGLKMFSIGCSIQIGLKLVFQMKSLIQKPKQFKEILFKKGTLNLACFLGGFAGLYKFVSCSLRRAWNKDSPEHALIAGLIASTSFLMYPDNTIALYVAWKAAQLLWNDGVEKGRVPEVKWFVIFLYCFSTAVLFHAAIVEPQNLRISYWKFLYNLSGGRIAAMSRVPIDEFGLESNKHLQAILKISKTHDKHVYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVP5</accession>
    <name>A0A232EVP5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001975">
        <property type="protein sequence ID" value="OXU22405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVP5"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="382" mass="44497" checksum="CF9E38DBE7A016BA" modified="2017-10-25" version="1">MKCFDSYDKSNLKTDPQHAINFLKKLGRFWTIWPVSANASRFTKVYHECSLWFIIINLFFASLTLWMSVCVYHKYPILMAKNLSQLMIISDSFSHLVLYRINRSELQVLVQEVFDFMKNSKQNEKYIMRKHYNRFLGHYTILIVLYVIASLAFFCGAFILGKKFPMDASYPFSTDSILVSSIIFTHQTFSIVQNSVLIMIDLLVITLFWYAGARIKILGYKFKIVDSNEKLKNCIKEHQKIIQYVASIVKAVRFILYKTISIVAIIIISAGLQLLYYDAKVVISQFSLIIIVACFRIITYSSTIEEMKQLNEDLRWTVYKSSWFCISSEMKQCLQIFIHRCQIPLVTIDGQLLNIMSLAFFAKLIYSTVSHLTTLRAIIERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWB5</accession>
    <name>A0A232EWB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_008729</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001899">
        <property type="protein sequence ID" value="OXU22616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWB5"/>
    <dbReference type="STRING" id="543379.A0A232EWB5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="979"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU22616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="120138" checksum="E2657B54DC823ACB" modified="2017-10-25" version="1">MRYSNCIFFSLAAAEKLRNTNSMLLNIWQILCLKTVWISIAIVGVYLYLKFVVFNYWSRKKVPHVPPNILLGNINKSFLLDKITIGDLVRQHYDKFRKEKYFGIYIFHNPILVINDLELIRLILVKDFPYFYDRGIHSNVDVDPMSFNLFRLPGERWKNLRTKLTPIFTSGKLKQLYPLLYEVSHELVDICDQILEETDVIDMKDLVERFITDCISNVAFGFNCNSLKDPNNEFRNNGKSGTDVGKYVATLSIFGSNILNFLRLRVFSSNVNKFFIRIFEDVVNHRVENKIVRNDFINLLMELTDHKQGSDKAPIVNESDPAGKMKNRKLNMLEAAAQVFVFFIAGFETTSTTVTYCLHELAKYPEVQKKLQEEIDEVANSPEGFNYDNIMNMKYLDMTFNETLRKHPPVPFVNRLCTKDYQIPGTDLWIPKGMRLAISVSGLQRDPDIYPEPEKFEPLRFSKENLAQRSAYCFLPFGEGPRICIAKRIALMQGKLALATLLSKYTFSICDETPVPLKYSNRTFLTVAEKDFKLFLLAAVLTAVYFYLKLCVYNYWKKCNVPHEAPSIPLGNIPVSLFTGKKALGNLFWDWYNKFSQHPFYGVYLFNRPVLMVNDPELINLVLVKEFHRFIDRGWFSNEKVDKLSCNLFLVPDKPWKRLRSKLSPTFTPGKLRQIFPLMSDVSEEMIKTCETELKLTDELNIIDIVGRYATDVISSQVYGFSSSSLKHPDNDFRRLGMRGLTFGRFKMLMVIFFRDLLVNVNIPFNPKEVREFFTRIFAETVDYRRREKVTRKDFMNLLMQLVDKGMLLDDEQKPKGDNEANSDRISMVEATAQAYVFFIAGFETTTSVVAYCLLEMALNPDIQEKLQQEIDEVTERTGITYDALMEMEYLNMVFLETERKYPGVVFLNRLCSSDCPIPESNYVIPKGMPVVISTLGVQYDPKHFPNPHKFDPTRFSKENSVDRSPYVNLAFGEGPRNCIGKRFGILQSKLAIARLLSNYKFYVSQNTVLPVKFTSESFFVSPDHKLTLRFEPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWM4</accession>
    <name>A0A232EWM4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001839">
        <property type="protein sequence ID" value="OXU22750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EWM4"/>
    <dbReference type="OrthoDB" id="7694755at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812:SF9">
        <property type="entry name" value="MYB-LIKE PROTEIN X ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812">
        <property type="entry name" value="NEUROFILAMENT TRIPLET M PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1710"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1795"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1935"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2349"/>
            <end position="2374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2655"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2815"/>
            <end position="2836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2856"/>
            <end position="2968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2989"/>
            <end position="3035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2617"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1241"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1468"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1606"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1950"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1969"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2036"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2063"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2131"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2159"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2213"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2248"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2712"/>
            <end position="2770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2897"/>
            <end position="2930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2949"/>
            <end position="2963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2989"/>
            <end position="3008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="3009"/>
            <end position="3025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="3035" mass="346266" checksum="A3FA0EED1E39BEAB" modified="2017-10-25" version="1">MHTNQTGYGRNFRIKLLIRAKKYAASQDSSSHSSEVVFLSQLAQQKNHRLLETSTYILDTLPSCASVSCGRSTSKELRTSANGKMQEATEVSEPEPLLKMESSEIQDPPPMDQVKLEDIETPATPDSSKGEASSDSVKTESPKIWKPVLGKLQAKKRLMAFANKFNTMPKVHKLKTKGDKVKRQEKILAIEEIVREENQSRLAAQEARDLNIKNALHARRIREESRERKSEERFSRRSGSSYRRRSDRERRHSRDRRSRSKSRQRPSRKSSPEDERSSKSKHKDKKEKSDKKDRDRKDDSRHKQDESKHKEDSKSCDKHKKDDLKFVETKNDEKKVEDFKSSSSKQNEDVNSKDKDKKQDPTERNNKRVDSVSQSMKELINDGKSEEFKNDEFKEDSRVESQSSEIMKTDKSKHDRHEKAEKADRNDKHEKLETSKKEDSKSDRGSKEELKNEQNKREDAKSELEKREEPKLERQRKDSKSESGKKEDTKPDKPKRDDAKLETRKCDESKIDLKREDDRDESGKMKRDDVILKRSNSKDNKLDRIDLKDKREEPRMKVHREREREKDKIREMREKELLKCRNWREFRRYGFFIDDVGYIRRNDNGDKMGKQRLILYFCNFSWKKCIDRSAQDYNQYLQQMLMLSDERQHRFAFIAEGQNGPKEYPPETIKSTKTKPFLLFCENPRYPTYFDRQHILSTVSPNRREKMEDICEATQIRIITSEREEGHHERLWYKTMDPSKSISIRTSVDVPSFPRSKWDSENELSDDDNVFEKSPEDIILTKDGVHVDESVSESELELEKLPLQVQPHPVPKQNSPQISVKPQLEPQPIIHPQPQPKSDSKESKQSSVEPHIDEQPPKSKSKHKSKSKHNHSPSPKKKDRSPSHKKHKEEKSKHHEKHRSREDKHHHHHHHKDKGKKSHTEPEPKESSIEKPVKAKPATPENQQQKQPAQVEEPGDDKLVSEYEQFIKMVSSSDGKQSTESAEPSSFYEFSLEAKLAKEPPGGLKLDKVPSPAIEKPSKEIIKLPKSPLLAKPLIKNTEKVKVSEPVKESEKFVDKPTLQSQPTPGPQAPQQKQKQNSEESEANYESSKADEEDSRSIPSDWENVKIKEEKLSEGETSETTAEALTKLKTSKKRRKRRESWSSDSSSSSSSDSEDAKQSSKRRKRRRKRSRKASTSESESSDSSSSDSSSSEELRKKKRKKADRKRKKRKRSKKLSKKLKRKRKRKASTDSSSSDSDVKPPKKRSRKLKLKKRKKNKLSKQQSQNSSDGGEKTKSKSEKSDGKHQKATKMKEETKKPSKNKQADAVVEPEKLANQKKSEVDQIKLTKSPVITDSRNRHTSEDIYSEWERESSPRQIAKEAEKEPVQEETKSNESSRKKEKPSEDKNESSKSSKSQEKEKEKEVAKNEFDETKADEVTESKKNKKKKKDKEVKRESHQEFEAEWEKEGGCQQHAAKPAPTVVEEEPQKFATTSTSVVESTGKKSAIDWHDTDFDSLNVLSLTQLEQVVEKRESIFANEWEVDSLDAMPNPRATLPMKKETTKTKKVDKSFRYDVQTDTYVPVEVDIKKDGKKKKDKRVSTIRIWEDEQENAEREELSLSLEKNPPVENKEKVVSESEAKKMTSKVTESTESTVEDKARQEAANRRKSRWDVESQSEEFEHAPPVMWEVESNIWPDSKLGSLDIIKAEETTFNSPLLEAVSARVKDEVVKVNASSSRRYTPPKDDDIVDSPETLRRKMEEIAALERALNADSNIMKSLDDFKSFEVKDTLDLEPPKETEIAAAKEQKTEAYLKAKEEANASLSKSKDAASSSKRVKEEKKPDPLASWESSKQPQIEEASEFGIPPLAEIDSKIEASGSSYRDIFLDMESINFESNILKKLNNKESVEPVAPAEEKSKVSLKLVPKQVLTRQVNAVAPTNTSLPETFKKKICNMDELPQAAVVDTPKTEIVQPRSVSSKSPTPSSFKRKSPSRKDRESGKRRSVEKDSKEDKQKKEYQSRGSRRSPMSNWDNKEAIKSESTSRTASLSRSRSRSRSPRRRDDRSKVPYDTFKKTPQSSKSDRNKRRYDDNLEQDKNRDKPYDPMEILRERNYEGDKGRGSNRSRIDQDTPKSWRHSDHPDDKFPVNPYPNEYSYENKGRGWDDGSERDSKSHSRPGSSARPRSRERSSKSYDRRDRRDSRSPDSLIGSIPLSRRDKLPPLRKSPPRSSRRSPPPRSRLRSRSRSRSWSRSLTRSRSRSRSRSRSTSRSRFRNHELRPLDKSRRSRSYSPVRNRYPIDEKDRLEEEIRRIGEGINRPAPILPLPRPVEPSSASCVTPVRPTVDRTRRMDAIIQLTGESQDDMLLPPPPVNRAPAPAPGVNEPQSRYRYPNENENEPEYNTFYQGRNLTYPKIADESTDSPKRLSLDDRLELELGIKKQTPPEPSVSTSFNSPGFIPNASGYPHLPPGQHHGHFVRQPPTVLQKETTIRQHLNSPNHTLFQVGNVLQVVPTEYPPHPSPPATPASQILRIGNVLQVVPATTIEWAATPTQQQSTVTAPPLGVRYTPSVPPPQPNASPALLAGASPLPTSVAQIPPIVKQIVPITVPPPQIAVASPIITAPAPKPKPPPPEPIVQPVYNYEAILEARRVEKEERKRLRELKRKEKERRRFERAKRRTEKILGKSKVNADSSSSSGISTNIFGKPGDILAKLTAKDENDTNEDNEIEESKSPVAPTPSEEAETEAAIAEDEEEDDGDEEDDEEEEPEQEQEQQEQEEQEDEEENEEFDADIENEEESKELVVKNEEASVAAIPPPPAKGILILPGFGNLSMTNGILSDLEKLEAEAKENEEQKASMEKEEEAKLSTSMALKLFEKIRMKKSVQFADGIKPGEGTSPSGGEGDMPSPPPPASNLPSDLTLDISKKLRARKMRRKQKRTKPPKTKKKVKVKIIKLKKPKVTPLPTSILDDSDEMDNRSPPPPPPGSPPPPHLWPSYLSTFGTTMAANSALTGATTTAVASTTAVNSTSSVSVSSLPPAQAPPTPLPLLVPPPPLNYSIQPCSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX43</accession>
    <name>A0A232EX43_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001778">
        <property type="protein sequence ID" value="OXU22944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX43"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8738" checksum="58485C1A390297CB" modified="2017-10-25" version="1">MARSQLPSNLSAGKLYILGYENFAQNINNDLQLEIVMSLVQGFVFDNEDKTFYASITSDHPATSLRDNYGTRFKIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXT8</accession>
    <name>A0A232EXT8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001661">
        <property type="protein sequence ID" value="OXU23286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXT8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13504" checksum="731A7B6E1D2A213C" modified="2017-10-25" version="1" fragment="single">RPRRKISVFPRPAVSPITGCIHPRERKRNTQYSSGHIYHEAYASFCMTRWSICPPISTLASIRARTSGTHSECIKGLALYLSNRKRQIVAHSMTSLQVTINVSVRRSFVSLEHNALQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXZ8</accession>
    <name>A0A232EXZ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_015011</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001734">
        <property type="protein sequence ID" value="OXU23088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXZ8"/>
    <dbReference type="STRING" id="543379.A0A232EXZ8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU23088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="59639" checksum="D837DA0C7B2678D2" modified="2017-10-25" version="1">MQSQCYIPHVLIIGYAMTLGFFEVAAGLVVLGLGIYYYFTSNMDFWSSRGVKGPKPVLLFGTTRDLVFGRMSIAQHTTQMYETFQDEPLVGLFTNRKPILMVRDPELIKDVLIKDFPVFSYRGLPIASKAEPLSQHLFLLEPKRWRPLRQKLSPTFTSGKLKDMFYLLRECAEHLGSFLEDFVEKNPVIECRELAGKFTTDVIGVCAFGLNMNAIAEDDSKFRKIARKPFDSSTLSLMKNYLRFAAPWLMDLLSPIFYDRELNDFFIGTISQTMEYRKKSNVKRNDFIDLLMAIKDDPSKLNDIELTDTFLAAQAFVFFIAGFETSSSTISHTLYELAQNQPIQDKLREEIVEGLKSHNGELTYESVKSMKYLHKVFCETLRKYPPLSVLQRCSLEPYTFAGTKVTIPENTLLWIPAHAIQHDPENYPEPEKFDPDRFDEENVKHRHPSLYLPFGDGPRNCIGARFGIYQTKVGLIQILKSYKVEVCAETCIPYMVDPKKFLLTPLDGIKLKFRKVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY81</accession>
    <name>A0A232EY81_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ral guanine nucleotide dissociation stimulator-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001618">
        <property type="protein sequence ID" value="OXU23414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EY81"/>
    <dbReference type="OrthoDB" id="26687at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00153">
        <property type="entry name" value="RA_RalGDS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF312">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="198"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="591"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="76528" checksum="B438A6E71750271D" modified="2017-10-25" version="1">MVQKGAAPAAYKPNKLAPLLLCAPCKPAQRKNQSTTQWYVQQPTWRLWGEEKGDGVIYTVYLKKVRYHRPTRSLSASDSDDEISHLEWETVRVRFLKAGTVQRLVESLANDDGELESTYINVFLATYRATXXXXXHPLLSRLLDFAHRRLPGSELELKARHRLHRFSQREDQIDNCAAIYGNDSFSDSWSSYSFPEVPHRHFAEQLTRMDAEVFRKLVAHQCLGAVWSRRRSRSHDAATVLATVNQFNAVSLRVISSVLLCSGAGGDEAKPQERARIIETWIDIAQELRILKNFSSLKAIVSGLQSNPVYRLEKCWQCVPREKYEVFRELERIFSEENNAWTQRELLIKEGTAKFADTAGRSDRHLQKILQKQNTHAGNISYGTIPYLGTFLTDLTMIDTAIPDTIAEGLINFDKRRKEFEVLARIRLLQGAANAYNFSADPLFDRWFHSIVVLDDREAYRMSCQIEPPPPGSTINNRSAPPKKKHNHNHNHSNNHNSSGHRKNDSIASTSSSSSSQFYCDLDSLPSSPHNSLDRRTSPSQMSSSSSSSSLPSLDISLSSGGGNGSARLNNSNGAAGGLSSPSHSHKSSPDFYIIKVTMESDNVETEGVVLYKSIMLSNNERTPQVIRNAMLKLGIEGNPDQFTLAQVLPDREMVLPNSANVYYAVNTAHNLNFILRPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYI2</accession>
    <name>A0A232EYI2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001613">
        <property type="protein sequence ID" value="OXU23421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYI2"/>
    <dbReference type="STRING" id="543379.A0A232EYI2"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="202"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="353" mass="40080" checksum="E4573CC38D798CB6" modified="2017-10-25" version="1">MSNDVHGTINLVQKPESVYLTWIFKKFWQTKYASSPSRLLECMTSPDIISKINDNEHTWYFQIHVSDVSTINDMTLVDFTPVKARGILRLRLKTDLDADVDVIVECSLIGEKGRVLNSKITKCTFTKSFRTADISDIPYCYNEFEMPPVFRESGDAEENVGVVCEITYKRKAVEAKESDTTSVDVSSLSNDLKLLFETKKFSDLTIIVEQQEFHVHKAILASRSPVFLAMLENDMAEKQNNRVDIADLDYETMHHVLFYVYTGKVEKLELAGKLLGPADKYALDSLKNTCAEALANDLTIENVVKTLVLADLYRVGKLKKKAIEFMGKHFHEVTQTAGFESLLKPNSDLFKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYT8</accession>
    <name>A0A232EYT8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_015158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001602">
        <property type="protein sequence ID" value="OXU23460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYT8"/>
    <dbReference type="STRING" id="543379.A0A232EYT8"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000036">
        <property type="entry name" value="septin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="52"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="356"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="434" mass="50208" checksum="91977279C68AA9B8" modified="2017-10-25" version="1">MAAVDVERAKFITFIEIIMFEQLENSIRNLKLSGHVGFDSLPDQLVNKSVQNGFVFNILCIGETGLGKSTLMDSLFNTSFESTPSPHNLPAVKLKAHTYELQESNVRLKLTIVDTVGYGDQVNKEDSFKAVVDYIDTQFEAYLQEELKIKRSLSTYHDSRTHVCLYFICPTGHGLKSIDLVCMKKLDTKVNIIPIIAKADTISKTELQKFKSKIISELQTNGVNIYQFPTDDESVADVNTQMNAHVPFAVVGSTDFVRVGNKMMRSRQYPWGTVQVENESHCDFVKLREMLIRTNMEDMREKTHNRHYELYRKKRLEQIGFSDVDSENKPVSFQKTCEAKRSTHLQELQQKEDEMRQMFVIRVKDAEAELKEAEKDLHNKFDKLKRDHTDEKKKLEESRKKLEEDIQEFNRRRAQIAMQSQSHHTLTLGKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYX8</accession>
    <name>A0A232EYX8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001568">
        <property type="protein sequence ID" value="OXU23571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYX8"/>
    <dbReference type="STRING" id="543379.A0A232EYX8"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="431" mass="48024" checksum="50E1E59EE90F92A5" modified="2017-10-25" version="1">MKSNTGFLKVDRDNSDNEDEINMSDSDDSMNESSDSDSSVSDTDDDSDADNATAGSSGQNESGPSTSKGENNENDVEEEEEDEVIKAILKSKEIHRDHPPTISIEDTLSDICFHPTRDILALASITGDVLIYKYNNEQNELVSTQELHEKACRDIEFNEDGGILFSTGKDKAIMMSDVATEKLIQIYENAHEHPIYCLSLIDDNTFATGDDEGYVKLWDRRQKTNNPVFSLKEMDDFVSAMVTNDDKRYLVCSSGDGTVTTLNIRAKKLHVRTEDYPQELLCLGLFKHGRKILAAGSKGNLYLFNWGEFGLHSDEIPSLTKKSINCMIPITENIVVTGGEDKMLRATSLFPNRQLGIVGQHDMSVECLDICNDGTIIASYSYDNSVKFWNVSYFETLNVAQPLIKGGKQKQLKHNLPSSKLENASDFFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZZ7</accession>
    <name>A0A232EZZ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001431">
        <property type="protein sequence ID" value="OXU23991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZZ7"/>
    <dbReference type="STRING" id="543379.A0A232EZZ7"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="14708" checksum="75ADB6361542F268" modified="2017-10-25" version="1">MLAAVGRLTRNFGATLAPTPPRTMSSKSKKKTGKTVSTASGKEQEVRETLNFLRLTSQESTLPVDFSEETVGIAISAPPQEGEANAELVKYLASILNVRKSDVTLDRGSRSRQKKVIVTGSSVEKVTEKLKAEAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1S4</accession>
    <name>A0A232F1S4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001203">
        <property type="protein sequence ID" value="OXU24756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1S4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="11312" checksum="706DC78155D63BAA" modified="2017-10-25" version="1">MKLGELNLGKRKPYAVNEGDGKDDPKKYYLKEEKKGVQDEMLAKKEKRVKKMKREQKRRALENAEKKRGETQKTVEEAMNSNGTKGLVLNTQADEDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2I7</accession>
    <name>A0A232F2I7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_010896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001153">
        <property type="protein sequence ID" value="OXU24974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2I7"/>
    <dbReference type="STRING" id="543379.A0A232F2I7"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="450" mass="51838" checksum="E452D5CF0A195039" modified="2017-10-25" version="1">MSKSKTLKIFESDYYRTYKNLVKLIGLWPHENIHKKRITRFFITVLLTTFMILQGIRLYEELGNDIDVVLELIGSMAYFSGCILKYLTTIKAQAALQFLYEQIQGHWDTITNKRERQILQESASDSQLLSKLYMGAAYVALMVYTTSPVLVPIVLDIALPLNESRRKTFPYFIEYFIDTELYYYQLMVHGTICFTVSVLVYISIDTMYAACCQHLCGLFDIVEHRLKEAVKTNSNRIYLELDRTDILMHKLLNEAITLHQDSIEFAVLIENTYALCYLLVLGLNLAAIVLVAVDIVINLDDMNQIIRLSILYIAFSFHLFFNSVPGQKIHDKSINVMNSAYVYAIHNYCESRYFTEWYNLPLNARKLIQLVMHRSLNPCQFTAGGLFVLNIESFGSVMGLDDGLKTFRNSRTGFIGDFDLAATPTDLLLEIADCPLGEFLRRVDFRLVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2W1</accession>
    <name>A0A232F2W1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001092">
        <property type="protein sequence ID" value="OXU25166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2W1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="149" mass="17304" checksum="3E5B278E928C08EA" modified="2017-10-25" version="1" fragment="single">TPRVESSSDTPREEIDIDHLLNCFSKTYDAFCSKFTADAQFQQQHVPTPAYSEQISVASPQQTEMTNEQPQSQLLEVPSHWPTLYSLPKDADSLAFVAPNIYNCKFCRKHYLSRAALTRHINNYQAKRHLRCWECGLFQKCIRKYCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F458</accession>
    <name>A0A232F458_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-retinol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.300</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25033"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.300"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; retinol metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.300" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001089">
        <property type="protein sequence ID" value="OXU25177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F458"/>
    <dbReference type="STRING" id="543379.A0A232F458"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000145">
        <property type="entry name" value="Retinol dehydrogenase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="324" mass="36397" checksum="CF749D736655A915" modified="2017-10-25" version="1">MAPLPKTIIWGSTIASLTGFVYLLKDYNGGKKYEGNEKLTDKVVIVTGANTGIGKEVAHDLAKREARVIMACRDMFKCETARKQIVIDTKNKYVYCRKCDLASQESIRDFVKLFQKEHQKLHILINNAGVMRCPKSQTKEGIEMQLGVNHMGHFLLTNLLLDTLKASAPARIINVSSLAHARGKINTYDLNSNEHYDPAAAYAQSKLANVMFTKELAKRLKGTGVTANAVHPGIVDTELTRHMGYYTSGFSAIFLKPLIWPFIRTPKQGAQTILYAALSPELEKETGQYFSDCKREDVNPIAEKEDLVEWLWKTSEKWTHLSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4H1</accession>
    <name>A0A232F4H1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001009">
        <property type="protein sequence ID" value="OXU25502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4H1"/>
    <dbReference type="STRING" id="543379.A0A232F4H1"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19601">
        <property type="entry name" value="serpin42Da-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="45"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="409" mass="47009" checksum="2605EA55D5C2311D" modified="2017-10-25" version="1">MELNFEGINLFYCFLISQVVISTGVNMNSELNFLHISNSCSDFTSNLFQVLTSKQEDTENVACSSLSAYIILSLLLHGTDGETREEIKSGLNLNDLDKTQEELQSLFMHLNNVTDADLQLANGIYVDSNFQLRDCFMSKSQEYYQTSVEKMIFQNSNVAANQINEWVKEKTKNKILNIISSNDIDEYTKVILINALYFKSSWLNPFESQFTEKRKFFNIDGIETYVPTMHKTFNVLHGHIKSLRSSFIKMKYLSKEFEMILILPDEKDGLRELEKNFDWNQISKARCLTTEVELFLPKFKVEATINLKSALKKLGMNVMFTERANFSLMAEKPLYVDRVLQKIIVEVDEKGSEAAAATVAQIRSRRMVTDIDVFAVDRPFMFIIHHKPSSIPLFIGSIRKLGGNYKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6L0</accession>
    <name>A0A232F6L0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_009234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000792">
        <property type="protein sequence ID" value="OXU26471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6L0"/>
    <dbReference type="STRING" id="543379.A0A232F6L0"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="326" mass="37193" checksum="C019D89E871F99B2" modified="2017-10-25" version="1">MLLEILKLRHSPVAGHAHVTDFNIAATLEGDQLATSMSGTKPYMAPEVYKCSCEEYGVMGYGFAVDWWSLGVLAWETLSGSRPFAVHASTTHREALALLSERPEPQSRWSRGFRELVDRLLAIEPLERCSSLKELKLLSAMSKLDFEAVLGKRVKPAFTPPKDHLNCDPTFELEEMIVETKPLHKKKKRLAKQRSLKAESLAEDPVQSSEAATTGEEQQRRLAFIPEYRVYNRERELERLERERKERQWERELNTAMSQASTGEDDQQPQIDPSRLRCKPNQSIYCMTLKMKLYDTDVIALKSTISKVSLKILKVSLTKMCLRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6S2</accession>
    <name>A0A232F6S2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocon-associated protein subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Signal sequence receptor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000817">
        <property type="protein sequence ID" value="OXU26345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6S2"/>
    <dbReference type="STRING" id="543379.A0A232F6S2"/>
    <dbReference type="OrthoDB" id="10059529at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009779">
        <property type="entry name" value="SSR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399:SF2">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07074">
        <property type="entry name" value="TRAP-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="254" mass="29177" checksum="C2FCCAFD9E836B8D" modified="2017-10-25" version="1">MFSLFVTFQRDTSSCCCSAWKIGRPRMRQFILPLVRVSRDRSPDPRLVPLNCLLLLHRFLSGTSQEDKRTRIMSGKSKAFTKEEELLLQDFSRNVSTKSSALFYGNALIVSAIPIWLFWRIHLIDVYSNLISFVLVTLVSTYALAFAYKNTKYVLKHKIAVKREDAVTREMSRKLAEDKKMSRKEKDERILWKKNEVADYEATTFSIFYNNALFLAFVIICSFYILKTMTPAVNYVFSVGTASALLALLSTGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F769</accession>
    <name>A0A232F769_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mRNA-decapping enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000748">
        <property type="protein sequence ID" value="OXU26704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F769"/>
    <dbReference type="STRING" id="543379.A0A232F769"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031953">
        <property type="entry name" value="mRNA_decap_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16741">
        <property type="entry name" value="mRNA_decap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA-decapping enzyme C-terminal" evidence="7">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="487" mass="53267" checksum="2E8FEED1313C94A5" modified="2017-10-25" version="1">MTTDVSELRMNVAALKRVDPYVRDILETATHVALYTFNGEKNEWEKTDIEGALFVYSRIGEPYNSILIMNRLNTKNQVEPVTPGLDLQLQEPFLLYKNSKGNIYGIWFYDKDECVRISSMLNKLAKESDTSNKVTPKNKKTVPKKTNNVDIFSMLSKAQEDFNSNKSGGSEKPVRGINSKSPMSNAIGELSGAINAMNMAQDVTSKSVMDFFAKAKVNTGHFQAGDQPQTGNVVNEGKPLLARLMSHPAAHTLEHIEKQHRSITPQPAAPAQPQPGIIPMNNQSCDNSIITKLRNKMPSQSNANTASSAHMGGQEYSSAHGMPCSDMSSVLCADNSHSSSSFLRIQSPTANNSNNLVNQHKSNANVSNFVDAYESIHKPNDSVTGNAMSFDTLFQHSSTANVCDDLMGQPLTPKTAALNTSGSTPALIPPGMFAAPSPATAEPLHRPIEPLTRNQLLQAFNYLLRNDPEFVNKLHEAYVKSLGEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7M4</accession>
    <name>A0A232F7M4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000714">
        <property type="protein sequence ID" value="OXU26841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7M4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="414" mass="45975" checksum="190F7BF91345A7E8" modified="2017-10-25" version="1">MVSSWTLADLTIFKEKVNARLRDWIQNLSSIEVNEVLIHLELHTNAFPEDLRNDVLTVIEAEEALEYSLQENVQLPSSSPHDSHKEQDISLTMTINLRPQRHMETDPVNFETLQVPTLLNTIATNKVAPSHFSTTVQETIYAAASTSAHYSRAIGAQATIAPTTPQNTANSSQNMDIKNLIRTVLPNGDVQFISFVIATELQRAWISERELQRNQVKINNYILDQAEKVNSLSSKIVGLEAVTKDLQLQSVRNNTSKRTRPIFHSTAKAYCPSAPTAAHAPLPRSSCMSASQNHNVLMPAATASSQPACSSWERGVWPQATNNTLSQSNPRATYHATEAAVPKRRDRPRGSKKKMPLLTATIMLPVKKPATIIEVPAKLLQQIKKLVAQMILAQTNEISPTLGELHPWPELIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7P2</accession>
    <name>A0A232F7P2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000706">
        <property type="protein sequence ID" value="OXU26876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7P2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8387" checksum="8C6F57513DA0443F" modified="2017-10-25" version="1">MHENKGRVSNATSKFASAGNFALLVVNGAEASLQQRSSSEFKLQHVQNSIFVKFKIQLKAEQNQDVYFRLENQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8L5</accession>
    <name>A0A232F8L5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_005446</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000651">
        <property type="protein sequence ID" value="OXU27181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8L5"/>
    <dbReference type="STRING" id="543379.A0A232F8L5"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="12">
        <location>
            <begin position="816"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="664"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="742"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU27181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="905" mass="102695" checksum="418EF7F21B946477" modified="2017-10-25" version="1">MDGKISKFVRKHLELLLLEREENLQNFFKDLSPASLHHLERTGQALTKLSITNLASKGPGRFQIDLERADGLPLEHGLCSGDLVICIRSKEKGQTIRAIVNEIGESTLSISTNDDYEDIQEEEIFTVVKTDSDFTYKSQTRALSFLEKKELHSSSCLEIVRILFDTDKGIVQNLLTSEDSIPKNTLDDQGSINFYNPNLAKDQKSAVEFALKRRYFAIIQGPPGTGKTTTLIEIIVQLQKFGKKVLICAPTNVAVDNLVIRLGQTEAKPLRLGHPTRIAKEALKYSLDSYLERDDGFIILKDIKKSIKDLETNIGNSGTKYAYKEVRELKKEYRKRLIRLTCDTLKKCSVILCTLNSASANDGQLQYIPRDHFDVLIVDEASQAMEASTWIAIPNAPKLILAGDINQLPPVVMCQEATKGGLNISLMERAIKKLNTDCYVRLTRQYRMNEKIMTWSSKKFYDDTLEADDLVKNHLLKHLPSVKQEDDLTTEAVVYIDTCGCECEEFNTGVENASKGNLGEAVIVDKVVTNLVKVGLSHKDIGVITPYALQVDFIRRSFAAKSLNVEVSTVDGFQGREKEVIILSLVRSNEDKELGFVTDFRRLNVAVTRARRSLIVIADSETMEKDDLIVSLLKHIEDNGLLQTAEEYLSETIEKEIERIEITPQTNFKSKKKPKAKTKSSKREKGDEPKVPISKDQLKPNQIIPSKSVIKRKSKGTALSACANLKQYNVYETIAGTLSDNEDKDEVISEKKDEENVDNKETLKMEQNLEHSDIDISAHSRKKEQLMRNKEEREDKSHENSAKENDNFDKIVQEFNKSNSLCSFDGCKKSTKLIKLICEFCKKWYCLEHGLQEIHGCGNAIRRKEQHAFRHRKPETSTNREKDRFARKLKELEEARKPKKKVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9R5</accession>
    <name>A0A232F9R5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000651">
        <property type="protein sequence ID" value="OXU27173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F9R5"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17738">
        <property type="entry name" value="BRCT_TopBP1_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17728">
        <property type="entry name" value="BRCT_TopBP1_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000018">
        <property type="entry name" value="DNA topoisomerase 2-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000021">
        <property type="entry name" value="DNA topoisomerase II binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049542">
        <property type="entry name" value="TopBP1-like_BRCT0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049936">
        <property type="entry name" value="TopBP1_BRCT_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21298">
        <property type="entry name" value="TopBP1_BRCT0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="108"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="207"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="385"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="601"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="692"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="1189"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1299" mass="146270" checksum="2D0BED675C9791EB" modified="2017-10-25" version="1">MEGDTNQTAFDVNVYFVVPSQYESEKECNEDMWDAYNKCPDWDISPEWISEKRCLKMKPEKKDVFVMETFSGETFEKLQEFKCTIIGPRCLLSCFLTGEPIPEGLTPIFNTAMRGIVVSPSGFNAAIKSKIQKRVEYMGGIFTRQLRGSVTHLVTDTVISAKYERAVEIGIKIVTIDWIESVWITNLKDNIPASDKVYDKYKCPVFLNLIVTSTNLPKHKKEEVKRLVNSHGGEFMGVLDGSKIKIVITLQTSKLSDKLKYAMQNNIPCLKVEWIYESIEAGYSLPINNYQIKSTQACSTPEKSTGKFLFSLSNCVLVNEPFNFSTISLIPGDNPNFVDETLASATTMSSTIMSSTLSRESVQTAVPKTTYITVLDRLDIAQAKKAGPFLDGCNIYLTGFSSNYRDKLNRILNVGSATRLDEISDALTHVIVGDAMKATQDLRVIKSKGLYPYILKVEWLEECMKIQAPAPEENFLFNSKDTTQQAATEPPSPLSKKLLQRPKIPAAPLFDDSKFTRKPENDEASEIVQQYLQNSKSEPDNSLREILKLPSTENFDNDYNATKNQSISERWNDTTKKDIRMTMNAESRDDSAIPISQESIISQKLFRGLVFIITGFADEELIQIVGQIQELGGRIVDRKYSGIPDYGIVPILGAELKHTVGEIVTNLFIEDCIDNEKLVNIEYYHTPITIAQNVKPLANCVIGMSTYAGVERRYLSELSEALGARYQDTFARKTNLVKNTYSSTHLICPMPQGEKYNAAVKWKLPAVTAEWLLQCAAKMKLVNESEYLVGETMAPERLDVTITNDNATKLMGPPNGPTPKRHTLSKSDTGEDGMKTPIINKRLNNLISDKTPQSPFHISTPETPYGQLFKENPSPRTRKGWVKWIDHFPDIPIEEPPPKRKRSTPMSEVFREAWDYVAGRFDSEEGNEVRSASENENNAVQEANGADNPQSSHMVTNRKLSFSDENSPNKTPNNQAVKLQLEQLDNLLKEASNTPETRQSLSSERAKPYQLESNHQAVRCLAKESQPDSVGWEDPVKRVPPQRRSTLNEESIDLENEVDLEEIPLASKQEISKPKFMFSGIKEKAIAEKLIKELGGEVSTESSFDITATHLLCLKPARNEKVLGSIASGKWVLHYLYIEACRDEKKFVDEEEFELGNPKSVGKIPDPSSENEKMIMSAAHRWRMRLLKNPGGAFRGMVALLIVQQEKREQFERLIHAGGGIVVEAKPPYDSSPKSKKITHCFVQLKQVDQKLEWATMANKGIMCFPPQYLNDALMSEKPLNPRECVLPDFQKYLALLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9T3</accession>
    <name>A0A232F9T3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_015042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000647">
        <property type="protein sequence ID" value="OXU27198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9T3"/>
    <dbReference type="STRING" id="543379.A0A232F9T3"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="4">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="457" mass="51950" checksum="D4C473741A95D44C" modified="2017-10-25" version="1">MAPPKHIQTDMPACTLDSSEVTEDSDDFFNMWTSHKDWQKNGYSDKTIDYGIRSNPHRRFVWNSHLLDTVEKNLHRDWLLYIIHGFIGQSNVSVFGRSMFITIIARRSNKYAGTRFLKRGANFNGDVANEVETEQIVHDSGVSSLNNGHFSSFVQLRGSVPAHWSQDVSKMVPKPTITIDLSDPYVETAGEHFNGLLKRYGSPTIILNLVKKREKKKHESTLSDGIYTSVKYLNQFLPPEYHIQYISFDMARKNKGKEANVMGRLANIANTAVLKTGIFLSLHPYYNKNQVSNIKKFHIFTKNKTLQTGVIRTNCVDCLDRTNTAQFVIGKCALGYQLHALGILNSSQLEFDTDCVRMLEELYEDHGDTLALQYGGSQLVHRIKTYRGESWLLQARMMIEHEWESKAPQAPETYTSAQPSSESKKANSPLVLYRAFYNQCINNALLSLSEKAESSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA33</accession>
    <name>A0A232FA33_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tubulin-glutamate carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.17.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_010642</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:63792"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="Rhea" id="RHEA-COMP:16436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:149556"/>
            <dbReference type="EC" id="3.4.17.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:63793"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.24" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01000597">
        <property type="protein sequence ID" value="OXU27482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA33"/>
    <dbReference type="STRING" id="543379.A0A232FA33"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06236">
        <property type="entry name" value="M14_AGBL5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034286">
        <property type="entry name" value="M14_AGBL5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF12">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="161"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="754"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="887"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU27482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="900" mass="102153" checksum="C99734D9B55DDC4E" modified="2017-10-25" version="1">MEENIECGGFTFLNNFDSANLAKVEAVEINKTDNGKGENNKTYKSSSSIELPSYEFNIWTKHDCHGTEYQNNNKTWFHFGIKAAAQGVYVKLNLVNLNKQVKMFSQGMCPVFKVIPGHPQWERIREKPTFTADDKNNEFILSFNYRTSENPNAVTYFAFTYPFSYTDLQNHLKKIDAKMTKQNVNLADDIYYHRENAINSLEGRRLDILTISSYYNILTEREAKLKDLFPDENEERPFKFQDKKIIFISARVHPGETPSSFVLNGFLNLLLNREDQIAIALRRLYVFKLIPMLNPDGVAQGYYRMDTRGVNLNRLYLNPSKTDHPTIFAAKTLLRYYHNSYSLADDHVPEITNIHNISNFDTTSSIDTISNETNKLLQRVTLMSLEEKNKVIEQGSRVRNCLVQASEKSICKFRLSKQCTVIKLTRALSIIGRLLLTVKSQGYIENQPQSIESVENVPCKRLCSASNIKQSPRSSSEDSGIFLYIDFHGHASKKGIFMYGNHFDDPEDSSACMLLPKLMSINNPNFHFTSCNFAEKNMYLVDKRDGMSREGSGRVAVYKLTGLVHSYTLECNYNTGRLVNTVPARVKEGLHKIRGQLFIPPKYNPAIFEEVGAALGPSILDMTGNNPNSRLPNSQYRSLKGLKSYLKLISTNHYQTSLNKPLHKHNMQKPNGLPYTFLNKITLYDNVLIAGKTVNSGGDQCRYSQDSTPDESKFIGNFVMKSSSIYTTKFSNNTYKLFRTANIYGTIKKKMKNRISRQASLTKNSNKGKNRDSKIRAVSKIVTAHIQPKSKSTISSHNEKLMSKPNFSTKKQSSNREKSSKIKLPSVKNSAKKSAIYAKKIIGSKKSQGAHKSISRNAAKALINNKQKNKNNNSVSKSKGKKEISKSNRKSRKKSSSTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA58</accession>
    <name>A0A232FA58_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000620">
        <property type="protein sequence ID" value="OXU27360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA58"/>
    <dbReference type="STRING" id="543379.A0A232FA58"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF38">
        <property type="entry name" value="SYNAPTIC VESICLE 2-RELATED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="24"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="546" mass="60817" checksum="3E24D99E716AE20E" modified="2017-10-25" version="1">MYMDEVTAQKAVEQTGFGKFNIKVTICCALIFLNCAFCITSVGFVVPTAACDFQMTTIDKGRINAAPMLGMVVGSCAWGYYADLKGRRSALLIALFVQFIVDAISSVVPSYWTFVFLKFLSGFTFTGQMSVVFTYLGEFQPTKYRNTTMSFMELSWAIGVIFEALFAWAVIPFPFSYKTEWFFFSSWNLFVFASALPALLTGLWLITLPETPKFLAENGQRDELLKVLTRMYTENTGNTAEQFKEKLATSTSPSISALVAKYEISPEEAAAAEKKLSLSMNEKLMDMLASSKDQVKMLLRKPYAKRISVCSFIMFCMTSTYYSLMTWFPELFQRFAAFEAAFPDEYASVCSVSKRLAAIANETEEFMEAAIDPFGCDTPIDTSVYVNSIWLGVACLPCAILLPLTVDYVGYRIYLLFTATIACAVTIAFFFVKTSTQNLVLSCIFEAFTSLNISVTLCLLVELFPTNLRVMATGITLLIGRIGSLFGNMLFGYLIDDHCSILIIIMAAQLFLAASMCWAAPGRDKLRKIQGYPFLEVQNKAFSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAP9</accession>
    <name>A0A232FAP9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000591">
        <property type="protein sequence ID" value="OXU27513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAP9"/>
    <dbReference type="STRING" id="543379.A0A232FAP9"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="237" mass="27085" checksum="F48E2F78E209C208" modified="2017-10-25" version="1">MGKQNSKLKPEVLEDLKQNTEFSDAEIQEWYKGFLKDCPSGHLSVEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFLCALSVTSRGKLEQKLKWAFSMYDLDGNGYISRQEMLEIVTGVIVTSTVGKAVPKVMKESRTPFEKSIILHYYYSKDTYDDIPTPQAIYKMVGTVMKMPEDESTPEKRTDKIFRQMDKNKDGKLSLEEFIEGAKSDPSIVRLLQCDPSAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBM7</accession>
    <name>A0A232FBM7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_009647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000460">
        <property type="protein sequence ID" value="OXU28236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBM7"/>
    <dbReference type="STRING" id="543379.A0A232FBM7"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU28236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="265" mass="28950" checksum="5AC7B072297B4B88" modified="2017-10-25" version="1">MPSDVVLERLQQSSSSSDRVDSVTPMSALENLGFLHAFLASLSVIVVSELGDKTFFIAAIMAMRHPRLTVFAGAISALAVMTVLSVIFGYAATIIPRAYTYYISTALFALFGLKMLRDGYYMSPNEGQEELEEVQSDLRKREDEFEKETSTTLVQDPETGVIRKSQKTSAFMLLSRIFLQAFSLTFLAEWGDRSQLTTIILAASEDVYGVVIGGVLGHSFCTGLAVLGGRMIAQRISVRTVTITGGVVFLIFALTALFVKPTDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBY3</accession>
    <name>A0A232FBY3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000531">
        <property type="protein sequence ID" value="OXU27847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBY3"/>
    <dbReference type="OrthoDB" id="7658983at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032145">
        <property type="entry name" value="DUF4818"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16089">
        <property type="entry name" value="DUF4818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="20645" checksum="58E786372869B0C4" modified="2017-10-25" version="1">MDVLRDYMECVNYHWLVIVGTGLYVYLREICLIGLCFEVAEDPPFDPSYASLIFVFSTLCLLAEYRLWPRSLKEPPIQLMIIYEMLVSALITDLARRIIWIPLMNMTWCLTQESSKALTWLNSQMELGKYSHVTAAASYMSTKMAATHTAFCISVLAFLWMLDATETLDSLLIDLWAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCD5</accession>
    <name>A0A232FCD5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_015834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000426">
        <property type="protein sequence ID" value="OXU28491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCD5"/>
    <dbReference type="STRING" id="543379.A0A232FCD5"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="251"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="415"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="451"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU28491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="634" mass="67326" checksum="C00761D74FA4B904" modified="2017-10-25" version="1">MRLVSPAQVLVNRAPSQPPPGPQAPPPPSLYSQATPTSHSNATPGECLGLAACSAAAVVAQAQAVAVQQAQQQGSGLAAGLAALGYGGSPLGALGSPAQLQSTGLGLGASSTGRRDSFDRNTSAFSPSLEYNRGKWPQSYGALAVGPRTVAENNEVEFPMNAGTVTASPSPLGLSLTPPPSIGGSLGGLVGGANRVSAAPGAEAKFRTNAVPTALTTNGVFGSSSSLFPNLVGKPGRGGAAGVGGDKTTGGRSRLLEDFRNNRFPSLQLRDLANHIVEFSQDQHGSRFIQQKLERATPNEKQLVFQEILASAYSLMTDVFGNYVIQKFFEFGTPEQKSTLAQKVRGHVLPLALQMYGCRVIQKALESIGPEQQQEIVRELDGHVLKCVKDQNGNHVVQKCIECVEPRALQFVIGAFAGQVHSLSTHPYGCRVIQRILEHCTPEQTQGILQELHAATDQLIQDQYGNYVIQHVLEHGKPEDKAQLINSVRGKVLALSQHKFASNVVEKCVTHATRQERAVLIEEVCGFNDSALNVMMKDQYANYVVQKMIDVAEPAQRKILMHKIRPHLAGLRKYTYGKHIIVKLEKFFMKTANAMVGAAPASGTTGSSDLGPIGPPASTAGSVTTSSQQSTQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCI4</accession>
    <name>A0A232FCI4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_008333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ric-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000462">
        <property type="protein sequence ID" value="OXU28200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCI4"/>
    <dbReference type="STRING" id="543379.A0A232FCI4"/>
    <dbReference type="OrthoDB" id="10070774at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026160">
        <property type="entry name" value="Ric3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032763">
        <property type="entry name" value="RIC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723:SF3">
        <property type="entry name" value="PROTEIN RIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723">
        <property type="entry name" value="RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15361">
        <property type="entry name" value="RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Resistance to inhibitors of cholinesterase protein 3 N-terminal" evidence="9">
        <location>
            <begin position="190"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="679"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="736" mass="83468" checksum="DD9B3EC28D38D373" modified="2017-10-25" version="1">MTETTSEFGPRKTAIIIAIVAGCFGMLWPKILYPMLTGSVNPPHSADSSGCCDVIFESDVTAVDIMQELCHNIIRHHQVDPRVRDAIAGNKFNKLTPSSASLCREEVLARCGIDVSSFLAEKERLKKSYKQVLEEIRGFNGSLCLKMQFGVPLSRLGTPHLIRYHILMPHSTIRQERQTPPHAGSYHPALRERGRAIPSSHIVPRIQDRPDHIAPMKMRPPMGGAGHVVAAPKGNGSLGLLMPLYTIGIIIFFLYTISKVLMGIIMPLYTIGNVVSFLYKVLQVLRKTADSEIMRPEYSTAAAEREYQKLVFNPEVFAAAVTAVNGQPEQRERPTTPIEEPPPTIDELQEHQAPKSNGLAAGLSPNSKVQDDQDENELEEFHEASPTVKVLNMEMTTSCEGGQKCSRPTTPVLFTSHGHTEEKEEKSPPISIYLEGSLPPQCELLVTDSKTQEIQEEENVEVPVVLSGKMTLSLISLDQVAAESQENDQLENEAASKLKQSNQDNLSSERDDSEPKNVDKISSNNKVETGNQRKEHYESDEDEEEDEEDDEEEEEEEEDEEEEEEEEEEEEVEEETDEELEEEVKEREDFKVRNYVSQSTGLDKNHENKQKYNEDISKNLASRIGDDNNIAKESEVDETEDDEEPSEEEEYEEEEVEVVEVEEGEDDEEEIEVQGKVEELEEEEEDDEEEEEEEEEEEEEEEEEEDEEEETEDDDEDKEDSRTMKIKQPIVIKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCQ4</accession>
    <name>A0A232FCQ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000460">
        <property type="protein sequence ID" value="OXU28229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FCQ4"/>
    <dbReference type="OrthoDB" id="1357022at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041452">
        <property type="entry name" value="APAF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048975">
        <property type="entry name" value="WHD_APAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17908">
        <property type="entry name" value="APAF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21296">
        <property type="entry name" value="WHD_APAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CARD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1379" mass="158347" checksum="27D67B9391484956" modified="2017-10-25" version="1">MERRHQDVLRRMRQNIVDDLDVNNGIIIPLTTEFILREEDVIKIKKGKTKPERAAILLDLLPLRGSRAFEVFHQSLKHHYDWLSDGIDNMLESARPGTPVSDTPFFSPNLQPVSPLTVRRGKMIEELKSGLKNLQSNGYIALHGMKGFGKSCLTASTLHDKDLTSQLFNNEIYWIKFNYKRHIHEEILIQLNNLYHQIKNYNPLIESINTEFLENSLKQAIDNHFKISGHNKALLILDDVSDKQIIDKFDFSCKTLVITSDIGVLENRCHIFVAIDHGFTEDETLGLFAKVLNIGIDELPEEAKQINAECKGMPLLIAMFAAQFENFKYDMKDKNRKGRWGYYLNSLRTKNEKNKVIEQFLKIQEATFDMCIGQLKKEMKERYEQLAIFSEDVNIMPKTLEILWKEEPFIVDEQMLDFCHKSLAAKKWNDELRSYIYGIHDLLLCHLRKKLLPEQLRDKHRVFIERYKTYCNGDFSKLPNDNYSLSYIGHHLEQAEYFDEFPSLYTNFEFLQAKINYTGLNDLLIDLKKYRKYITNNGNKTIEANLQDLEKFLEKQATTLAKHRLMKCLDLVQIALDHSDEGFVKDTAKQLALSKQFSLYLSHDKNSFKNNYLKFSQEVTTQATCIAFTNDPNHILIGSIDGEVVLWDYENCKPKMFHGHNKKYPIKKIVLSDGGSYFLALSEDGTCKLFALNSDEFTGNGLNIPAQSPRHKQTFWTNIFDSIHDDSLKTFAIKHEFITDMKFTPELSEISETPEIKKSDIKIAACTNAGTVALWNENGNLEWQDAYKTHYFGGVAFTSGDKFLHVMNETISVVRIYKKNQNSGYTYLSQFNLQLDSPKVIYFSKNPNPIENNCLVIVTDKMALYLKWFSQDQEYLQRYEKYIKIEEKSKNTFYTAATLTYDARYLVISNSKGTISVLKAFNADDLITYFKGYVTSLDSYYFNEENHLICGSENRIIYMWDISADEKPKSVKTLLFDAKMANLGEDNTVFLKTLPNTITIYNGNNELTKIESLHGKISSINLSNDAKKLIYMTELGSVVIYEVATAELRKISQLDSVDNYIDILELQDNYFVLCRTADNNMQVSRSPKASQSLENTGYVISINKLNDESVMTVSKEGKIICWIIEDYEWRSCYECIDENGTIIHSCLSIYKTFLALLKDEQILVIYRMPDMDTIESNLGKLEIFMKHSYKNPLSSCQFSQDEKYLAVALEGGDISIIDVMTSLELARLSLHCSTVCQLHWSPITINVPILLSVGCDELAWWNVSFLKTPDRSQNRRSRMGFSRSVSSPIVGMSPRSSYRLPNSPMAPPTSPSVNVNEFWSRKLQKTSDADRPALLCCIQLPATCAGPTKVCVSDDFAKFLTVDIHGTVSNYTIFGSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCS2</accession>
    <name>A0A232FCS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_005014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000473">
        <property type="protein sequence ID" value="OXU28137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCS2"/>
    <dbReference type="STRING" id="543379.A0A232FCS2"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46287" checksum="C99A6CF7E32F6201" modified="2017-10-25" version="1">MPGPDLPETPAPLKSIQPYLKTASEHDARDVVVSYWCRLYALQTGLKLSTKTGEETNFLLKLMDWLESTKKAHHENEAITNEVAAQAHLENWALKLFLYADKHDRASNFGKNVIQSFYTAGLLYDVLTTFGELSEEASQNKKYAKWKAAYIHNCLKNGQTPVPGPAKEDGDDNSNENVGSDLLDYDENADHENNDPGVQPSQPTLPAMPMQPPMIPTRPTQPTPPTTMGAYDFPSVPAKDEDNKDNDENNERDENNEGVENNEEPAENDENKDDENNENLDNDENNENDESIENNENVETNESDENDESHENNDNNEEAAENEENQDDGKDEKSEPHPYNPAPTPTNPGNNRVTYDDKSVGIKSETGVELTVELSGKAQKYIKWAGSSLNYDDVPTAILNLRKALHLLTTGEDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEA7</accession>
    <name>A0A232FEA7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000399">
        <property type="protein sequence ID" value="OXU28657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEA7"/>
    <dbReference type="STRING" id="543379.A0A232FEA7"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="69"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU28657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="522" mass="59348" checksum="38E2BFC32FB14729" modified="2017-10-25" version="1">MSQFVTVQVGQCGNQIGSAFWPLVLHEYGVQTTSGSVNLLKTHKNYGRNSKELAEAFNSFFHVPDHRGDFAFKHVSDLELARVKARAVLIDMEDSVVGRFRQGPLRNLFDQTCTVTNYPGSGNNWFLNFCYYFDVPLIERTEDTAVGYYTHGIEYHNKLEETIRRTVEKCDCLHGFLVTHSLGGGTGSGLGTATLKLLDDYYPQVDRSIQNYFSYCQTIRSPCTILIINFYRFVSCVYPASTQDVITAPYNVLLATRELIEHATCVFPAENRALQDMCNVYMNNRRENVDQAKYNASCLPFQDMNSIIVNMLLHLTSGSRFPGCLNTDMNELATNLVAYPQLHYIFSSVSPVALTASQISTTNGTKYQDELFTNAWSRNNQLIKVDPLQSGSLVIGAAHIYRGDSSLTDIRRNIERFQNKAKFTSWSKEAMKIGLCSVPPAGHPASLLCMMNSTSMSLLFKDIIQQFDRLYKKKAHIHHYLQVDQFEKEDFIESRERIVSVFERYNKIEKQNPVSISRLQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF07</accession>
    <name>A0A232FF07_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_008175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000360">
        <property type="protein sequence ID" value="OXU28897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF07"/>
    <dbReference type="STRING" id="543379.A0A232FF07"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="167"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="560" mass="62412" checksum="10498B06999AD5C1" modified="2017-10-25" version="1">MATTVSCSVGTTITETDDRNNKQQKHVEGGTRRRNGYSKTLNGHASFIGDGKNNRNLPPKSSKYKESFEKVPFITAALTHFGFYILMFLGFINQLLFTPNVAKERKRKGYAPLYESFEQFYLRYVYRRLKDCWNRPICSVPGGTVTLKDRVTHDYGWTFEFTGTTTECINLGSYNYLGFAESSGACAQESIKTLKEFGCAGCSPRLELGNMPIHDELEKLTARFLGVEDAIVFGMGFATNALNLPSLISKGCLVLSDEKNHASLILGLRLSGATTRVFEHNSKLINVEHLEKCLKKAILSGQPGTGEPWKKIVIVVEGIYSMEGSIVHLPEIIKLKQKYKAYLYLDEAHSTGAMGKRGRGVCDYYGVDPRDVDILMGTFTKSFGSAGGYIAGTKALINHLRVYSHAHTYAVAMSPPIAQQIITSMKIIIGEDGTDAGKKRIKQLARNTRYFRRRLNQIGVIIYGNEDSPVIPMLVYLYSKIGTVVRTLTTRNIASVGVGFPATPLMEGRIRFCLSAAHTKEQLDYVLKNIEDISDTLGLKYSKKPRDPNSIEYYSDSETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF09</accession>
    <name>A0A232FF09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000343">
        <property type="protein sequence ID" value="OXU29048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF09"/>
    <dbReference type="STRING" id="543379.A0A232FF09"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF117">
        <property type="entry name" value="LP05237P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="392" mass="44852" checksum="519DCFB8F184E939" modified="2017-10-25" version="1">MSARLESSMTTKNYEATWSTFDEKLLTNERKLKDLLDISSSNDEESILCSFGASGGTTISRMLARKSIVWAKDSLERLPIRLTLENVGVFTLFLVLLMPRAITYWLLYPLYRLVFGTLYPAYASYKAVRTKNVKEYVKWMMYWIVFALFTCAETFTDVFFSFWFPFYYEIKIILVLWLLSPATKGSSILYRRFVHPALCRREAEIDDALARATEQGYTAVLQLGTKGVNYATTVLMQTAIKNLPNVVPIGALAASQSDPAISSLANRRASPSRSATDGTTMAEPQEQMSRRKPRRRSRSENVMEVKTEKRHYHVEAESDGSELIDVYEDLDMDYMPSEENTEDSLHFDHFKEPEPAVVANKNNKKTRDDSVTRRKPRTRGNTGRNVDSEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFR0</accession>
    <name>A0A232FFR0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_015208</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000295">
        <property type="protein sequence ID" value="OXU29393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFR0"/>
    <dbReference type="STRING" id="543379.A0A232FFR0"/>
    <dbReference type="OrthoDB" id="337575at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17086">
        <property type="entry name" value="RAWUL_RING1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16739">
        <property type="entry name" value="RING-HC_RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000219">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000100">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042741">
        <property type="entry name" value="RING1_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="178"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU29393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="435" mass="48077" checksum="6937F4EAE9F39B53" modified="2017-10-25" version="1">MLCSASRRHNTATTDRSRRLVFVVSPLQHRSSVNMASTEQVGLNKTWELSLYELHRTPQDAITDNTEIAVSPRSLHSELMCPICLDMLKKTMTTKECLHRFCSDCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDLLISKIYPSRDEYEAHQERVLAKLNNSHSQAALVNSITEGIKLQSQNRPQRSRKNANEPEITNNTASYNNTPNVSAPTTPNPAVIAANQSDSSQGAIGQSSNGGSRENHSTTSNGVPQPSISPAVSGTTSRNSTTPSPVPSNPKPAKRQKSLQNSENDSSSAEAETGGNDSMVDTEGEGSSEPLMLNEIELVFKPHPTEMAGDNSLIKALKENSIRYIKTTANATVDHLSKYLAMRLTLDLDTELLSESDRLLNFCIYIAPTTGQLVVLSGSQTLRQVKDKFWRVNRPLEMYYSWKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFS4</accession>
    <name>A0A232FFS4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_006559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000332">
        <property type="protein sequence ID" value="OXU29157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFS4"/>
    <dbReference type="STRING" id="543379.A0A232FFS4"/>
    <dbReference type="OrthoDB" id="10250728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371204" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="9">
        <location>
            <begin position="454"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="600" mass="66493" checksum="D0B8DC6203E4A390" modified="2017-10-25" version="1">MKLLLLFVSLNALVALSLGSDITNAVFGKDLDGMPAAFGDFNSDELTDVFVLSKDGRTVKIMLASVEEPLLQSRKDLSCDFEDKVSSVVPGDFDGDVFMDVMVTTVSSAEATRGATNVHILWGDNNKLNCNGSLAKNAIIQMQGQPLAMDYNQDMIIDLFGTDVNGTRAFWVFNSTKTKPSQVFMKKPKELETWLPIRAPHANAFLDLNSDFYSDLVVTTEKFLEIWHGGENGFTFHKTLPTIFKQYPNAIVGQSLHSDVELMGKMDLVLPVCTDSSCTKSVIMVHSDSSSDWIELQVEFADGTGVGGTWGFALQGGQRYTDTITMRGGDFNMDGYPDLLATLKNSITQQTRSFLLENVHCKSNCGKFNRTFEVRWNALSPFFNESVMAVFYDFYQDGILDVILVLKSDKIYKTAAFKNSLDYDANFVKVMVLTGRTNSQYPISPGSLGKKKRTYGTNLPGPSIAYKTTTQDGSPRSAIAAQLPQSAHFSLNLPFTTFGLGRTPNFIDSLTIGLSNRSREWPQIIPNSQMVVIPNPPEDPSRWKAQLFVTPSKLILLSAAALTGTCGLITAIIAALYWKERREDKIEKLQEAHRFHFDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG41</accession>
    <name>A0A232FG41_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000286">
        <property type="protein sequence ID" value="OXU29490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG41"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7622" checksum="3FCDF052C1485B15" modified="2017-10-25" version="1">MPLNKGYFSTDLKGLENSVTRHFFDVGTWFCMVLNMYNKKKKLRKCTLTFVFFSFSNQKMAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGA7</accession>
    <name>A0A232FGA7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000248">
        <property type="protein sequence ID" value="OXU29715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGA7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012240695" description="Single domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10358" checksum="8FE94EC1A55FCC53" modified="2017-10-25" version="1">MKFFVVFGVLCLVALSTQVPLFEGCDEKVQKVFDKESCGHVQCYNFSNETVTVNKMSYNSCAIPSCEGGLELKGQNPEDVTKTYPDCCATPICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGC7</accession>
    <name>A0A232FGC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Microsomal signal peptidase 12 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000297">
        <property type="protein sequence ID" value="OXU29377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGC7"/>
    <dbReference type="STRING" id="543379.A0A232FGC7"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="10938" checksum="4E842618A9D10904" modified="2017-10-25" version="1">MGSIVDYFKNIPLHMDYEGQARAEKLSRIIITLFGVVGLIWGYIIQQFSQTIYILGAGFVMAAIITVPPWPMYRRHPLEWQKPVSENLSKAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGG4</accession>
    <name>A0A232FGG4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000277">
        <property type="protein sequence ID" value="OXU29548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGG4"/>
    <dbReference type="STRING" id="543379.A0A232FGG4"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="503" mass="58314" checksum="38385EC61D8627E7" modified="2017-10-25" version="1">MAKLPNKITTREVINLEEAYECQAYYKLPHCARYCMQHSIKRCALHYTCALNYNSKAFRKVRPYRFSLNSLYSISDSIGYPLVARLFIIGLTSHQIRRSCSTKSTFLFHKSKPDSGQPDFYHHQVSLSSNSTHVIWLEQLLWKIIYIGLENTLVDSDDFNLVVRLSDNEFYGISLPLASTVPAARGDTFSRFFIRFVISYADRAFELLEDDETTLRKDSRESRAKKDNNNLCAFSNPELDMISKDIKELIQEKHGLEQDISQKEADIKIKNGEIKSLQSELDTLAATLKQLDNQKVEAQKRLNDLQTQVEKLRQQASDQESNLHVHESELNNKRQEIECLKQAEQNLETKQHSCNQNLNSLSQLLQSVQLQISQTKAKMTQLEEQQRQIVDVITQYDAALTIGDASVITDSLLTFKAELNRATVNGTGNLKQMNNKDSYNNNDVVENDNNFTSFENRKNDNEIDRDPFENNLYEGRNQNIKRKNEIKDSFRLKKIWWKRTLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI76</accession>
    <name>A0A232FI76_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000158">
        <property type="protein sequence ID" value="OXU30454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI76"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10257" checksum="835F11D19E2D1B4A" modified="2017-10-25" version="1">MSTVSRTPSNTRPVPFPRTLLIDQPQPLRRSSKHATTQATPAEMYTGFDLRLSLDLIRGCLPEEVEIKGDGDFVHRLRRKLSEIHKMAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI99</accession>
    <name>A0A232FI99_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000164">
        <property type="protein sequence ID" value="OXU30402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI99"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="211" mass="23475" checksum="290B65F4CB4994BC" modified="2017-10-25" version="1">MSRPDSQALRQLRAECELLHLLLAKTNRALILERCQHRKSLTADVAAQTEPVPDHRHNSAQTDPPLTPRHRPNTPESSSNMLNAEWPEHQQLIDIPAWITTDSDLRDLRLYHPDSSSRGSGHTATAKQFAQTTQRKSIGISPRKGRPTAGKLSPTKRRPTAPRSPGQRRKPRVIANEILKIPLSIPLGKALLVEEKTEPMASVAVDLTTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIL7</accession>
    <name>A0A232FIL7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_015425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000174">
        <property type="protein sequence ID" value="OXU30309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIL7"/>
    <dbReference type="STRING" id="543379.A0A232FIL7"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="248" mass="29473" checksum="7465FDBBB415CCBF" modified="2017-10-25" version="1">MSGDEEDTLLDRDKDKCLHEYVKLTNYISFSQTEIRKELSQMSFEDLQKLKEKLGTKVYNAAMFGVKKTKAVAFKRENKNRPREESAKKQVSRFREIIPVKKKAPRDPRFDSLCGTFDEKAFKNSYAFLNKVRENDLEALKKELETEEDPKQIKKIKYLIQRLENQLREERKKNEKKEKEKQEKEEIANAIKSGKKPIFKKKSEKRIENLVSQYEELKNSGKLKKHIQRIRKKNLKKDRVRLDNSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIV0</accession>
    <name>A0A232FIV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000153">
        <property type="protein sequence ID" value="OXU30513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIV0"/>
    <dbReference type="OrthoDB" id="7697863at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="76058" checksum="5F85BC03DD6B8B32" modified="2017-10-25" version="1">MSQESESDISEMEGFVPKKRREFSSEDESLNLSKYRKLTTEQKLKDLKTEVTAADTSYESEEEDNESYVDRRKNSLSDEVVPDSNKQQENSHSSNENITETNTPSTMKQEYQDSMETISESDVDSLEVSATEELNLLEKLRKPFEKVQRLAFISATYRISGRKMNTSQFSCNANVTVNGAVAHNEVINKTIKKKNSALYEDDKTDEKVEANRSLNSCEETTGSDNIELEKVAKSEFVNTQDLADTQIMDNSLEPDNIKTEIASQVTVPANVEKFSENVDSESRKSVSENINSENSKSISEDVDSAYKNAASENVDYENEKNLAQDVEKEPAVIENVDTANGESVTMTSHSENMPVLSINSNFNNDAQTESMDVETSGTGNTEMKMNIQTTEPINKTTEAPKSNVNECFASENTNHSRINETEQEAAILNLLSHANFDITDGNQVVSEVIIPENAEEIYTEPNNSSNAPTYEHSYQDPSTSGVVGEVFTDASRANSNLDLAQLVLSIKQDIQELTKKVDRQGNVLEAVVNANEINLTPLFAQTFQEKYNLQLPFTKIEDFDKFNQDLGKNTRFCNEFITSLCSYIDNNVTLAKNILNMLRKYMSKELATLYTACKATGNKMVLKDTLFCKCLLQATKLTIRNGLLPLEHEKAFLKNLGLVVSGAKNWVTHEDERRKSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJD5</accession>
    <name>A0A232FJD5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000135">
        <property type="protein sequence ID" value="OXU30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJD5"/>
    <dbReference type="STRING" id="543379.A0A232FJD5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU30650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11982" checksum="DF5CED54006B09E7" modified="2017-10-25" version="1">MPVNLPNHNQFDPNALRQSTIPATAYRELKILKYAKYENIVRLVEMIMHRDLKPDNVIITKNDVLKIADFGLSRLFKENSNGEHNRFKNRVVTMVPATEAFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJQ7</accession>
    <name>A0A232FJQ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_012766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000129">
        <property type="protein sequence ID" value="OXU30698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJQ7"/>
    <dbReference type="STRING" id="543379.A0A232FJQ7"/>
    <dbReference type="OrthoDB" id="5875866at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040024">
        <property type="term" value="P:dauer larval development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF45">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="12">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="13">
        <location>
            <begin position="462"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="686" mass="73071" checksum="E8BE46838099A77D" modified="2017-10-25" version="1">MVGLAGGGAHLYPSPPMQPNPELREMPGMTPAAPTSADACLSIVHSLMCHRQGGESEGFSKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCQFAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSGVGVGPGGRLVKDEYSVGGGGNVAAGAGAGVGSGMDVDGEMNQTIQHHPPPAGQPAAPANPQQSQQPFMPNLAQPAAANGEGMYNGVVSSSSNGPRAPAPTGKPHLDDAAARQTWIPAAPSQPQSQTQTHHSPTPRNLHHRNQQQQQSLGSTGGSSSSQILSPTQGPSSSESFYSATSPPQDLNQAPTPVDALQATLTGGSQSSPVSPVHLHHQNGFAVATVANPYNTGAPQWTGNNTLTYTQSMQPPDHRHLHATPYWGNHGGEVPGNIGTGATPGLLSSQPAPEYWCSVAYFELDTQVGETFKVSSNCPTVTIDGYVDPSGGNRFCLGALSNVHRTDQSEKARLHIGKGVVLDLRGEGDVWLRCLSEHSVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHKQMRGQAATAQAAAAAQAAAVAGHLTHGAPITKSLSAAAGIGVDDLRRLCILRLSFVKGWGPDYPRNSIKETPCWIEVHLHRALQLLDEVLHTMPIDGPRGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJT8</accession>
    <name>A0A232FJT8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000099">
        <property type="protein sequence ID" value="OXU30994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJT8"/>
    <dbReference type="OrthoDB" id="7691758at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144682" description="CUB domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21940" checksum="5CBE1E2A7F13B328" modified="2017-10-25" version="1">MRTKFSLFCLFVALCATLAHAKLNDWHFQAVSVRSHIFESLRPKGNPEVIKECGSVVTKPYGQLEQVYKRGQVAADTTCTWKLRAPANHRINIISVGFDLSDSHSDTPIDYDSAKNSGVSLYNSEEAGEGLMTTFYTSPKEHGSSGFVNSISSQENMVVEVKYHDNINYDTQYIKIKYEFLPVDKMQELLSKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK30</accession>
    <name>A0A232FK30_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_002781</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:137009"/>
            <dbReference type="ChEBI" id="CHEBI:137017"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:53185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41143"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85222"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:56461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45544"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:45545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53168"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85217"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:53169"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000103">
        <property type="protein sequence ID" value="OXU30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK30"/>
    <dbReference type="STRING" id="543379.A0A232FK30"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08612">
        <property type="entry name" value="GDPD_GDE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052271">
        <property type="entry name" value="GDPD-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="14">
        <location>
            <begin position="50"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="330" mass="38798" checksum="F5B4D4065145CD3E" modified="2017-10-25" version="1">MLFYTLFGSYVLTSILLFKYPTLIHKKKKIKFMCRHISHRGGKYFFVNFIFMLSIIAGAGENYENTMCAFKRAAAIGTEMLELDCHLTKDGQVVVSHDQNLLRCTGYDVNISDLNFKDLPLLKQRIPIDFVPGVEYVGSDKEEERKFVLLKEVFEEFPRMPINIDIKINNDELIFKVSELIKQYQREEYTVWGNYSDEITRKCYKMNPNVNLLFSMKRVVLLIILMYTGLLPFVPLRETHLEIFLPSIYRRKDRQIPSFLPIDKVFLGAMNVLLMRPCLFNHLQARGIHVYFWVLNKEEEFQKALDLKATGIMTDYPTKLKLFLKNKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKQ1</accession>
    <name>A0A232FKQ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_001006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000074">
        <property type="protein sequence ID" value="OXU31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKQ1"/>
    <dbReference type="STRING" id="543379.A0A232FKQ1"/>
    <dbReference type="OrthoDB" id="6369184at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="120"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="339" mass="38476" checksum="F0EFE492632CBDD8" modified="2017-10-25" version="1">MQATAAAAADVRRGSMTRDRQASNMHRVLPNSDYIYLQRDSPITFTSVSNRKKANIPQGRKVRDRVSRKTVWEGKEITEQRKKVAAKNERIRRKDGNRRKKDYAERAENEKEASCSCVVYSSRYNPQGGTFTSPDYPKRYPANIDCLLYTFHARQDEIVELTFHHFQTRGSNVATERDQMRFLVIFGLHFVVCESERYFDVDDKAVQNIANDENHSCKALNKSSTVKFTENCAGGDFLKVFLHLEAGVRGVSEYTPWSRLLCGGLQDIPRQLYSSGPTLVLELHTQPATRASNASDTAPGFSGTFRFVDSQIIAIKAYIKRNIVTAAELLLKALMRCEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKR7</accession>
    <name>A0A232FKR7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000105">
        <property type="protein sequence ID" value="OXU30927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="219" mass="25020" checksum="C36F814A21EA8EE5" modified="2017-10-25" version="1">MGKNERASETSESKREGRKRKKKEEDEEMRRMKEKMVEMEKTLKAALDEIANQKESVPRKRVRTRKYGASRTKTGRLVSTVLAVTPYTYFGSSSVLAETRSMRKINTESDSGSESEKSSCGEELETPKAQAEKFLGEDPKDKKEKKLVINEVLVSRINEYLKAGLQKDLKDGIIEGTPRIGEEINLEPPELNGEIVYGLNEAARKRDEHFRESYKMXNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLP1</accession>
    <name>A0A232FLP1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_001035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000053">
        <property type="protein sequence ID" value="OXU31503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLP1"/>
    <dbReference type="STRING" id="543379.A0A232FLP1"/>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF0">
        <property type="entry name" value="NUCLEOPROTEIN TPR_MLP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="775"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="241"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU31503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="906" mass="102989" checksum="7823E534BBD3F7A2" modified="2017-10-25" version="1">MSIRICIDQAADLERQMRSMQLDMDNLQRQLSSATLDRESAIQENRRLQDDLAAVSCEVRSILKDLEASKAESQDLKRQLQTYVTEVRRAEELISEKENERTEMLNHFRSLSLEATVLENNNHSLESEAAEARGALQSARDQILDLQRQLSDKDCLVRGYEAQITELTQNVASLEIQLQQATEQRLCAEEDLRTVRNLCMTLEQQKECISQRLNENTDLKTQYEVQLSRYRSEQEIFQDQMNKDHVQIDRLEKLLEEARKETMDCQSNCRELQNEVSKLKKKVSELQSKLSAETAEVRKYQTQAAEYNKQITELRRQVTNERFERARMQEDSHSECQTRKEITCQTRATRVNGHPCSSIQPSVTPNPSKRYSKALVPRNQRTRASQSSNEVDAGKLSCKICACSNNGSETIDSNRFKFHITELSSSSDGTRDGCCATNYKNNCCQEKRQQLVPSNHFTCKENLLRDAQIEGVANYQSVNRVCFCTGQTKIGDLIAKAKINKDINCKKVDMQNNLFSKDLNSKPTTSNSIGSLEPSGHCGRCGGRKKQKQCTRNMSPSWIAETLNLMSKLLEGKKKSVHKNEKCTDNQSTCKEIALNIVKQDKVTPSPEEKKIELSNNMLKTKQHIKYSLIETCNSNCTVSTQTLESIITISDNSRPHLLKILSEIQQYAKSIEDLFYVMNETAMQQQRNNNHEGNKEQNFNNGSTTQPVLAALASSEGEQALQDKPAELNSSINTSIPAEFPSKHTLFGEDDFDVSKLVAVPLASTPRDSVTLLDSNAEPTEQTLNQPMRLESGQEPSEMDSIEHLSLPKEQRLILARSRESDEDSTEYLALPKVIRSGTSEYENTTQFSRSVAAYPEDVQDNEVDPELEAIEEKIERLRRDVFMDAEENLYEDKNTDTDKPSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMF2</accession>
    <name>A0A232FMF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000016">
        <property type="protein sequence ID" value="OXU31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMF2"/>
    <dbReference type="STRING" id="543379.A0A232FMF2"/>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="199" mass="22963" checksum="34FB938F98D62A0E" modified="2017-10-25" version="1">MTYLNIPSFSGDDEIILSYDTVQNITIDFTRPVIILGPIKDKINDDLITEYPEKFSSCVPHTTRAKRDNEIDGQDYYFMSSREEMEKDIQNHLFIEAGQYNENLYGTSITAVKEVASQGKHCILDVSGNAIKRLYAAQLYPIALFVKVNSPDSMLHDRGMKVLLSFVYTTRSKRSKFFLMVDFTGEKYYVRQHKTKPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMM4</accession>
    <name>A0A232FMM4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000016">
        <property type="protein sequence ID" value="OXU31922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMM4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12509" checksum="E8A5AC1059DBA297" modified="2017-10-25" version="1">MTPCFPFMAVDPDNMLPTSYACLSLIASAQENLGFSSPRCLQLPEGEEKKYSVFKWPHIPRGLRVILHDALEHLSADLYSRFNPRPYVRNNDHIIAIFRCLKKYFCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMM7</accession>
    <name>A0A232FMM7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000018">
        <property type="protein sequence ID" value="OXU31905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMM7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013394006" evidence="2">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12078" checksum="14D944054C7E3CB4" modified="2017-10-25" version="1">MNEVPVLVSMTCAWWLFSIANQCEAGLVGKISFREEITPGVREHFGNSTSDSIQTSRKIRDMMGGDKSTEIPLEVESTKITPKAEDAQFSDYADSLPPLPSIIKSEPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMV8</accession>
    <name>A0A232FMV8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMV8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="8337" checksum="A4728415FD8749C5" modified="2017-10-25" version="1">MTKDYLTLQVMINGQCINRFFEENHTLTSTSEYHQFGQGRDPYPPDNPLRTLCSKHTKHPEDWTVDKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN83</accession>
    <name>A0A232FN83_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000007">
        <property type="protein sequence ID" value="OXU32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN83"/>
    <dbReference type="OrthoDB" id="7613924at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="842" mass="92796" checksum="6EC88B3A059534E4" modified="2017-10-25" version="1">MERFTPIDSKLQHIRRANGKIDGRRLLELNPPKSFCASNRLFCYSQEEIGAIIESVPPRRDDPPEKKNNNNNNEYISTVGAVKETSSRSNSIRRQRQFESRRANDWSENILAEFNNIIANEISELTKSRSQSNDYRDLLTDLGIPNSDSGTEEDAVTKDEKRTFDEMKSRHQHMLSADYDEPRDQIRRRQRRISGSLPENLEYPTSCNGTSPNATSDYDEPSNCLMQSVSRSVAELRNSSSSPASSSPKSQHRNVGLPLKKPSTDPMPRSHRMLKAFARSRNNNLDDPRSQLPPQPFQRKSSLPGNGLLSNQSQKKTSNYGKIRKLKPSEAEPDYEEIHDPHLYEVIGRSKSLENNMPRSAPSTPTEVKRSPFSRLLKRHKHAPVYRDSSAEAILVRVSSLPDQDLVKTGTLRDTDTCRKKRAVSPLTLRSDATAKRLSESDKDVTQISPVELRRFQVTKSNANDVAVSCDFPEVERSEVDEEPLVTKNNGDDKAMVDAQNSRSASLPISLQSILSRLTKSGGSWCPNSPPMEGLACSDMATQTSPAISRSSSFTWVSDCESPHHDLHADAGSLQDETILNPASPQNTVDDDNRSSSSSQDLLQSMDEISSGSLSPDTTDRASPLESGIGTASPPRSTDRRLVKPPTSSSTGTILPATNKCHRKETWERIRRRPSKLNSSRDQHEDEASVWVKRESVHTQTRSAADEERDYSQEAVDSSSGLDDSLPRTGKPARPNNLPLGQFDSLVISAHLGSSFLGGLDMSLILAVLRGLSTTASSSVSSGELVDTSLPRALSSPSTASLQLKTAEPVAIELACKSNSAPLLDNNGSSPEKSVTEEPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED88</accession>
    <name>A0A232ED88_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007411">
        <property type="protein sequence ID" value="OXU16315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED88"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="170" mass="17900" checksum="56DB07D75519F6D7" modified="2017-10-25" version="1">MTALPPEAAAAPVVAATAAGVVVVSVIYIATVVCIVRKVRIAVTSNVYTAIMIASRVALEKTIIMGIQGPVPMAGSSDLIGVTINSENFAHGSAATYVPLGAGRKKSFGINVLGQRSLISIIRNSDNLCLPRALVVDEAFVNLKEEATDTTKKAWTIYVTVVVLYKRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEL0</accession>
    <name>A0A232EEL0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005288">
        <property type="protein sequence ID" value="OXU16787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEL0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7762" checksum="854AF6E98949610E" modified="2017-10-25" version="1">MFKVMVHTWQRRGHKFYNSVFTIIGQGLQNVKNALVRTYHRALKIILAHPNQWNLQPLWIYSVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEL5</accession>
    <name>A0A232EEL5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005269">
        <property type="protein sequence ID" value="OXU16806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EEL5"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU16806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1086" mass="125034" checksum="68D018B4EA5B602C" modified="2017-10-25" version="1">MEVMETLKITDIMPLSFFYLKLSGAWKPSSWPSYLRLMTFFIMKVMIVAEILYIFAEENQLKVLKGNVYIICTLINGWLKMFNLICRRKNIANLVNSCIAKPWNPPRDNYESSVLAATKHTSSRKITVVGSCVVSTLLNSVLSSTPVLTLDAWYPCNITLPICFWTSFVHQSIGYTVTAIVHVAKDKIVVGFMMQICAQLNVLNRRLLLVHVEVEKAARQQKDQSQITCLETTLVNECIVNYRDILKQVYICYTRVSTLMYVNXRLIYDSYTILMTFFIMKVIIVTEILYVIFAEENQSKVLKDNVYIICTMINGWFKMFNLICRRKNIANLVNGCIAKQWNPPRDSYESSVLAATKQTSSRKITLAHASVVGSCVVSTLLNSVLSSPPFLPVDAWYPCNITLPICFWTSFVHQSIGYTVTAIVHVANDNIVVGFMMQICAQLNVLNRRLLLVHVEVEKAARQQKDQSQITCLETTLVNECIVNYRDILKQVYICYTRVSTLIFAEQLSETFIEMIFIQFCAGLSVICTSVYLLTTLNICSFEFFGMFLYLWCMLGQMFLYCWFGNEVVLNNQTQXLLNSVLSSPPFLPVDAWYPCNITLPICFWTSFVHQSIGYTVTAIVHVANDNIVVGFMMQICAQLNVLNRRLLLVHVEVEKAARQQKDQSQITSLETTLVNECIVNYRDILKQVFAEQLSETFIETIFIQFCAGLSVICTSVYVLTTLNIFSFEFFGMFLYLWCMLGQMFLYCWFGNEVVLNSSKLFHSIYNMDWIKLQSRTQTKLLFMMLVASSPIQLFRGAIIRVNLDAFINILKFSYSAFAEQLSETFIETIFIQFCAGLSVICTSVYVLTTLNIFSFEFFGMFLYLWCMLGQMFLYCWFGNEVVLNFEALPLDLYNMDWIKLQNQTQTKLLFMMLVASSPIQLFRGANHPSEFGCFHQRKSFFLNSIRCCTFAEQLSETFIEMIFIQFCAGLSVICTSVYLLTTLNICSFEFFGMFLYLWCMLGQMFLYCWFGNEVVLNFEALPLDLYNMDWIKLQNQTQTKLLFMMLVASSPIQLFRGANHPSEFGCFHQHPQVFLLGVQYSTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFD4</accession>
    <name>A0A232EFD4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005079">
        <property type="protein sequence ID" value="OXU17032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFD4"/>
    <dbReference type="STRING" id="543379.A0A232EFD4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257649" description="SWIM-type domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="297" mass="35704" checksum="324ECD7D9F400A32" modified="2017-10-25" version="1">MHSLIVLIFLVEDGNFLTEIVGVGIVRREDQDTMDWIMSSFKKHHHNNFQIIKYFMSDKNQTQRQAVKKICPNIVLLICLYHTIQIWKRQLSKMNLSSKQKEFYLDELKKLAYAENINIYEYRLREMVKECPECILSYFFQNWDDIKLQWTCYNEHHGTFYNRTNNRTESINQKLKQVIDKMNKMSNPLQAVTHFFTWKNFHDNENKRKIMRNFGSILQREQSEDEKKYMNYLMDGPGEIVLNEIKNKNYITFDNDNQNNTIFTIAKSKRETTYKECNCTISIAYKLPCRHIFAAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFQ2</accession>
    <name>A0A232EFQ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004958">
        <property type="protein sequence ID" value="OXU17177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFQ2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="20195" checksum="1D842E4EE34994C2" modified="2017-10-25" version="1">MEEIEKMKTIKREYEQDKVQQDNVSQIHENIKVDRKEREMKQKSKTSQHEREIEQKNHKPESKQENYQISKPSETKDKNDSKSKEKSEFRGERKEYEQKQKLAVLFTVSSRSVFLVSNLEGNQDYADHLVHFLLRNKPITIYDYGVDDFEQLYTLNPKVEKLTLGNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGT3</accession>
    <name>A0A232EGT3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004693">
        <property type="protein sequence ID" value="OXU17543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGT3"/>
    <dbReference type="STRING" id="543379.A0A232EGT3"/>
    <dbReference type="OrthoDB" id="7697376at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="348" mass="38567" checksum="A27B1D12646252FE" modified="2017-10-25" version="1">MERLDDFRANALENSRAAQGRQEKYYNAKHRNIEYKVGEKLWARYHILSSAAQAIAAKLSPKYAGPFIVTDRIGIHHDEEQFPKNSPVPQDSDSPVPEPLTSPKKDEHAAISQPAPSTKTTAGSAPQIPTSAVPKRRGRPRGSKKKTPLPTETIMLPVKKSATIIEVQAELLQQIKKLVAQMILAQTSEIPPTLGKLRTWPKLLRSLGETTRESAGLLPDRPAPALPAPAEPENEEVAPQSTSPDTPPPSTIDHLTSALEQWTARGAKSRACRRARQQAQQQEKATYEEVLLFTRHPDQGTEGGRATGASDQGKSPREEQKQALKLEQLRKLHKLEEIRTQLHKLEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH12</accession>
    <name>A0A232EH12_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004636">
        <property type="protein sequence ID" value="OXU17624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH12"/>
    <dbReference type="STRING" id="543379.A0A232EH12"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012918022" description="Plastocyanin-like domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU17624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="168" mass="18730" checksum="2460442E9B162C08" modified="2017-10-25" version="1" fragment="single">MSRLVALILVPTLQLCMLLNITVAINDNHPCHRECNDDTVPMTCHYNFILDVYSSMSKKCADCPFNLTDCFNPGCIPAEGKRKALYLVNQQLPGPAILVCKGDRIIVDLKNDLLTETTSIHWHGQHLQDAPFMDGVPFVTQCPIPPAGLFRYDFVADSAGTFVWHSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIG1</accession>
    <name>A0A232EIG1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004238">
        <property type="protein sequence ID" value="OXU18159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIG1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="11371" checksum="0800B19F29F93E8F" modified="2017-10-25" version="1">MMVLTALKQVATAATNAVHSATGGGSSHHHPAATSGRSLQFKSPASRICRARREIFTFKSFVCWPGETSREVFRLSNSSLDSRCERITRAINRTALLFVYAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIG9</accession>
    <name>A0A232EIG9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004259">
        <property type="protein sequence ID" value="OXU18134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIG9"/>
    <dbReference type="STRING" id="543379.A0A232EIG9"/>
    <dbReference type="OrthoDB" id="7700475at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="240" mass="27838" checksum="A135B9A74A4787E6" modified="2017-10-25" version="1" fragment="single">MGKKKSHHRDYSSDDRDPASSDEGRRKRTRKHKKKSRRRRRHDSTSSDYSSRDRGINNTLLSILFVTTEKRSRRCSRSKSPRHRYSQSRSQSRSVRSSNATLPSPPTPPAPPEKEPTEKELTSKVLDIIGKRIEEEKALAPPVHKDFAFRWAEIMKLGLSSEERIELCKKYPPPKNCEFFNPPKLNAEVHRAINDNVRTRDKRITDKQRKLVASLSIIAKVISFLLERERTEDIQAIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIV5</accession>
    <name>A0A232EIV5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004152">
        <property type="protein sequence ID" value="OXU18286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIV5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9754" checksum="CBC59D1DA1A521F6" modified="2017-10-25" version="1">MTLRIFKTILQLQLELLSKAPVSLEPSFSSEEIDLFLTCGQLLKEKHETKTNATHFVKNLKLIYLLEELQVLQKYGVYDLKTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIX8</accession>
    <name>A0A232EIX8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004144">
        <property type="protein sequence ID" value="OXU18305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIX8"/>
    <dbReference type="OrthoDB" id="9938256at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12616" checksum="CE37BA3F08D0DC65" modified="2017-10-25" version="1">MPANYVSPDVKSTLTLDEIRQRYRDTSLVIFKEHQLFRGRRTGESEREASTYLSFGINRRTMAYSSNGNDPVLVHRSMKSVTIHEDENARLLSRVFRGYRKPSESCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIZ7</accession>
    <name>A0A232EIZ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004155">
        <property type="protein sequence ID" value="OXU18281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIZ7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="127" mass="14603" checksum="71AEBB30AE996D69" modified="2017-10-25" version="1">MIHRARQNIRQNRILDNRLKFHKVKEIPSELEGYIISDTGNVEKLGNPLDIIIETENRSYDGILKDVTFTKLLTNNNNKKITDTTSSCKLSENSLRFYIVVQAKETIVHSIRFNLSCGSSDQVHQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ45</accession>
    <name>A0A232EJ45_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004088">
        <property type="protein sequence ID" value="OXU18389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ45"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7918" checksum="7690943ACBEAA7C8" modified="2017-10-25" version="1">MLIGIKIFIKNIIRVKEKESDQKFEIELQSDFGISMAFMIELDIKVEMEMSNRDKVRNTKGRQYHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJB5</accession>
    <name>A0A232EJB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004039">
        <property type="protein sequence ID" value="OXU18460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJB5"/>
    <dbReference type="STRING" id="543379.A0A232EJB5"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22540" checksum="DD8041290ADFE2F3" modified="2017-10-25" version="1">MAENLGKRPSKGILKTSSSFDNQETPSRATKETKWDEMNIIATLHPADKDYGHMKIEEPKTPYNFEGAKNDDHLDSSAVASKLEKNIKPKIFEESSEEEEDEETPEEKERRKAFEAKRKGHYREWEAVQLARKKLLEEEDEEEETNNERDEEDEETEKEEDKDDVEKSEDNQRESDKKTANKCVPLSENDTESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK30</accession>
    <name>A0A232EK30_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003881">
        <property type="protein sequence ID" value="OXU18724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK30"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669416" description="Protein sleepless" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21281" checksum="206D284FFE0DEBBF" modified="2017-10-25" version="1">MSISKSVIALALCFLLSTESVFSKVGKCYQCDSATDVDCALNLKQKKFIFNCKDTPTGEGFFNLNENIANVEFVCVKAIITKSFFGNKTLKMLVHGCGTKDTCNEKPDPKTGITLAECNTCTNSFWSNVLQRPVGGVYKTARATGVPFFLRGFSWKVFLVEMFSNLLAVTRQSLCLFRQIFDTVTGQGLGNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK81</accession>
    <name>A0A232EK81_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003877">
        <property type="protein sequence ID" value="OXU18732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK81"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8382" checksum="B0ED08A6E69078EE" modified="2017-10-25" version="1">MVSIVEIFELISYINGGTRPFEEGSRIVNFHNILLCGHCEIKQNSQTDKYFETVAATILFLRSTNITSTVDNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKB6</accession>
    <name>A0A232EKB6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">N-glycosylase/DNA lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_013277</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01003821">
        <property type="protein sequence ID" value="OXU18799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKB6"/>
    <dbReference type="STRING" id="543379.A0A232EKB6"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="108"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU18799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="317" mass="35307" checksum="A9B85C841C768630" modified="2017-10-25" version="1">MTQILNKYANRIGLSIFKVTESVLKMSSTTSIEKSSDEISSYILCEKDELDLGITLKGGQSFRLDVSLKENLKSWAGTDSHFKTTYDKIGAVRILNQDVVENLFSFICSSNNNITRISGMVDKLCRLFGEYICTVEGQDYYDFPTIEKLSSSELENILRKEGFGYRAGYIVKSAQKLLSLGENWLLGLKKENGATYEHARESLMSLPGIGPKVADCICLMSLGHLESIPVDTHIFQVACSNYTPHLSKQKTVTPKIHQEVSSHLRELWGPLAGWAQAIVFCVKINSTSSKTSKKRPISKAEKNKSVKTKVGRNNSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKW4</accession>
    <name>A0A232EKW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003718">
        <property type="protein sequence ID" value="OXU18961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6177" checksum="1E0C8072158E1980" modified="2017-10-25" version="1">MPRPGSRSAYMPSKALLLFGEYGSRLAAARGTSGTVGELQRCRAGCRHPGACAKEPAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELR4</accession>
    <name>A0A232ELR4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003513">
        <property type="protein sequence ID" value="OXU19296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELR4"/>
    <dbReference type="STRING" id="543379.A0A232ELR4"/>
    <dbReference type="OrthoDB" id="14717at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097500">
        <property type="term" value="P:receptor localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00878">
        <property type="entry name" value="Arf_Arl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06894">
        <property type="entry name" value="PX_SNX3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051995">
        <property type="entry name" value="Ciliary_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="28"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="243"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="465" mass="54231" checksum="EFBA36BD6DAAE253" modified="2017-10-25" version="1">MADTTVDATRRLNIKKQTLDDAYAAPANFLEIDVINPITHGLGKKRYTDYEVRMRTNLPVFKVKDSSVRRRYSDFEWLRNELERDSKIVVPPLPGKAWKRQMPFRGDDGIFEEDFIEDRRKGLEVFVNKSIVLLVVGLDNAGKSSVVNYIFNKSLLTQESVVPTIGFRTVSFDYKSKYSVRLYDVGGGPQIRALWPKYYADVHGVIFVVDCNDHRRLAENTAVFQDLVCHDLISQKPVLVLGNKQDLREAVDELDLIEIMKIEQIVNYAKSYTRVEICSCYPDNHKHFNLNKNIDIGFSWLIQDIGDNYEALEELLEERRAKRNERWLHTIKSWTAESFENSFEYTDSDSELYMKPIIPKNEYKKRRKRRRTLKSVFCIANNRTAPMSDYDNNVARKKSTKEMIRSMRIEELIRSTEIDADAVMRYKRPWIRRKKYRPKTAPAAAKPFEVKPVESPIPNQLPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMT6</accession>
    <name>A0A232EMT6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003316">
        <property type="protein sequence ID" value="OXU19638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMT6"/>
    <dbReference type="STRING" id="543379.A0A232EMT6"/>
    <dbReference type="OrthoDB" id="206339at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189564" evidence="2">
        <location>
            <begin position="23"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="546" mass="63232" checksum="0B6DB2488DF46841" modified="2017-10-25" version="1">MIKVTFWISLFVLAAVINCVFGQEFVNYTKYRTKNDPSCFHMSWLGSTHDEKRNVNCSDPAYKGVPCIKPHIISKTLPNVTDLWLNKQRTDIYCDLQEGYSCIKYTYTFNNKVANISYFCGKMIEGFDALDNGCFTQKVHHFIKFDKCGIISNIQTHLRQNLVNALKNRDLAQKFDKTAPKSAKHEAPLLINFNKHVKQCGGSESTSSSGSKQKLQSDYVCHTLETLGIEPTKAKGQSIIKEYENSDLPLLLCILQCIKTVEDRLRATTNSTDGYESHKENVLRKTFKKFEAAKKRLIQQKDLFNAQLRQKENELKEQTLIMEKQLTILQDKLEKAQKLMHTYDIKQKQLDETKRQQCLQLVQKETELAIKENLLSQEANRLEKERDSYRHFEGDMKKLQNELLKVQKEIPPVVDRGDCNLSTKDAEIQTEFEKSFVSARNETNLLNQEKHDLSGLVQEQRWRIEQLTAKVLQLSRKLEETHLKRLSVDAQVPVSSIRVLNTNTIISESSSTEDILQDAKMRLRRLEEESMKADQYYFNFMGNTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENA9</accession>
    <name>A0A232ENA9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003202">
        <property type="protein sequence ID" value="OXU19811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENA9"/>
    <dbReference type="STRING" id="543379.A0A232ENA9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="16684" checksum="8950956C59F9E166" modified="2017-10-25" version="1">MHGLKANANPGPDDISAHFVKCYLPISTISCLPKVLDALVTDELASALTLQLADQQHVFVKRRSTLTNLLVFNDFLLDALDKHRQDDALYIDMSKAFDKVNHARLLSKVWNFGVRRVLHSLLASYLSGCSQAVRFGDCILPIMYVASDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENN3</accession>
    <name>A0A232ENN3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003128">
        <property type="protein sequence ID" value="OXU19936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENN3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="214" mass="24877" checksum="56893852E524C9A0" modified="2017-10-25" version="1">MRSGPLGKLSTSFRVERDSEECSADSRQLLPSHDAHAMNQLTKRQLVVGLGVESNAKRDSVGSSIKSQRDVLPRVRSSDSESADGDDWHTVRRKRRRRGLRVKLFDESWKRVDSLVSLSSDNESREKSPRLSSTWREAYEEALLEARVKLRDELATLEHKRRLQRVREEAREAAREQVRVGRRNRSTDWRKSEYGESYVCEPQSKRLIQFARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENR7</accession>
    <name>A0A232ENR7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003079">
        <property type="protein sequence ID" value="OXU20013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENR7"/>
    <dbReference type="STRING" id="543379.A0A232ENR7"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060560">
        <property type="term" value="P:developmental growth involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19337">
        <property type="entry name" value="Wnt_Wnt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF77">
        <property type="entry name" value="PROTEIN WNT-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012150019" description="Protein Wnt" evidence="11">
        <location>
            <begin position="30"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="389" mass="42980" checksum="39EC6ED0989F27C3" modified="2017-10-25" version="1">MSSRHWTRSVKSALDIRLLALLLLELALGSLAGSRRGGTWIYSGLRGISLLEPASSSSGNTDLPGIVDVRTMEASSLCSSLKGLSQGQEKLCQLSHDHMPCVARGAKAGIHECQHQFRHRRWNCSTSNDESVFGPVLDLGSRETAFVHAITAAGVVYSLGRACRDGQLSSCGCSRSGRPKDLNREWIWGGCGDNLEYGYKFAQSFVDVRERERSYKRRSRQHGRSLMNLHNNEAGRRAVIKSSKVTCKCHGVSGSCSLITCWQQLASFREIGDYLLDKYDGATEVKVNRRGRLSIRDPRYSLPTANDLVYLDDSPNYCFANTSLGSLGTRGRTCNRTSSGIDGCNLLCCGRGYNTQKSTISERCDCKFHWCCEVQCSTCNKSVELHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ81</accession>
    <name>A0A232EQ81_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002795">
        <property type="protein sequence ID" value="OXU20549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ81"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850587" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="10681" checksum="13572A70ACE91FF5" modified="2017-10-25" version="1">MVKTVLFIVFYTAALIECNASPETTMQDSHRVARQAEIMNSEESSENSQSWFQRVGTWIYESVQKAAEAAQQTIHNIVSGVMTSGMPTSGPIQQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQQ4</accession>
    <name>A0A232EQQ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002727">
        <property type="protein sequence ID" value="OXU20683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQQ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11789" checksum="7B3FB8778388F5EB" modified="2017-10-25" version="1">MVVIYGSILVPVTCKNLDSSRENALELVYDGTDMKTVITKNDAIHFKSNNLISAPFMDRPNYYERCLFSGHIPPKAFKYLDYNGFIVDKNQIPILYLRFFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQU7</accession>
    <name>A0A232EQU7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002696">
        <property type="protein sequence ID" value="OXU20759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQU7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10272" checksum="9BADC4B24A9580C7" modified="2017-10-25" version="1" fragment="single">FCYSGVFAVAEHEYRDGNALLGSWCPGWAVSTSSPTVSRKINDFFVFCYSGVFAVAEHEYRDGNARLGSWCPGWAVSTLLFTPMFLLYIDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERA4</accession>
    <name>A0A232ERA4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002671">
        <property type="protein sequence ID" value="OXU20806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERA4"/>
    <dbReference type="STRING" id="543379.A0A232ERA4"/>
    <dbReference type="OrthoDB" id="8193822at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="4">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU20806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44092" checksum="6A848E8D55D7811E" modified="2017-10-25" version="1">MKNEGTGSPNISPEDKQELNSGPLNVCVYLDDTIVYAKTVEEHNDKFAKLLRRLKVANVKLQPDKCDFLRREVSYSGHVINEVGIRPDPKKSKHFSKIAKPLSNLLTQTVPFVWDDKAQEAFDILKEKLCKEAILIYPNFTKPFILTTDASQTCVGAVLSQGLIEQDRPVAYVSRVLNDAETRYDTYSREALAMPGRINLNADALSRNPIEESTETVMHILQETEERNRASQEQQPDYNTESQIKSQEGRPAGNAPKAMHEVNASLTDPEAVNTGRSETEEIYRAVEPTREREINILKEFPEPSEETRAEATKQRSRSYGKIFVECKEQLFMRKDNYLYFLTSKGTPCDKGARLLEERNELPRLYNLSVGELKITPESNKHHFIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERV6</accession>
    <name>A0A232ERV6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002546">
        <property type="protein sequence ID" value="OXU21085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERV6"/>
    <dbReference type="OrthoDB" id="6332063at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="18893" checksum="5F5CAE41C75C7226" modified="2017-10-25" version="1" fragment="single">TASGKESPLTSNSALVPCNGSKVEKSSGNLSYDWAYGASPLAERPELKDRVSVTANGALLINRFSGKDHGKYTCRVRDGNSVVEEVTVDVDDKYRLLAEVCHPSGCISAEKCDSPSETRTSCLLDGEVCCSVVREDAKHRCGHFLGECMKSCTQEIQVLQADDCEEGTTCCVLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERZ5</accession>
    <name>A0A232ERZ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002528">
        <property type="protein sequence ID" value="OXU21133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ERZ5"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01659">
        <property type="entry name" value="TRX_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991">
        <property type="entry name" value="L 2 01289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991:SF3">
        <property type="entry name" value="LETHAL (2) 01289, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012714617" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="42"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="374"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="708"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU21133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1341" mass="153736" checksum="08BFAE0F85728CFE" modified="2017-10-25" version="1">MSTTNDASRGQQHQHLHRRCCFLLLLLLLLLTWFGASPASAALRAPSKDQPSQQYHGKEQGGGGGAHGKAKEDPVIEEVTSKQLERLLKEKDFVAVYWYARSCTTCDKVLAELEKIDDDTDTFGVDFVKINDKRLAKQYGIKTFPALTYFREKEPIIYEGDLMDEENVLEFLTSLEAMDLPDRIEEVNAKILGKIVEDADFVAVLFYKPDCKKCARALQELENIDDEADQLGIGFVKIADERLAEEYNLGPLPVLVYYRHQIPIVYERFDRYRSQFSIIDTFFRCTEELSREEDVLEWLIANKSTGDEEDVIEDVTAKTLTTLIGNIDNLVVLFYDHGDEDSMQVLTELEKIDDDCDKHGIQFVKIDDVKAAKEFGIDSIPAIVYFEKQLPNVYDGDLQNEDEILEWLLSQLEKDEIEDVTDEMLDRLVKEGKTLAVLFYDNNDRKSQRVLNELENIDDECDQLGVVFVKIDNAEEAKEYGIEKIPSLLYFEKGIPTLFEGNLEDEEKVLKWLDSQQKSDHIEDITDEMLDMVIDKMPHVAVLFYDKDQKKSAKILAELENIDDDCDEHNIAFVKIDDAEEAKEYGIDQLPTLVLFERKIPHIYDGDLMNEDQLLGWLLHQKKHSEIPEVTDEMMEKLIETTPYLAVLFYDKDDKQDIRILNELENIDDELEKEGIVIIRIDNEAEAKEYGIDHLPTLVYFEDKIPALYEGDLLNEDEVLKWLIEQKNTATIEEVTDEILKDLIDEHEYVVVYFSGNCEDGDECETVLKELENIDDELDETGIVFVTTEDTGLAKKHGIKNLPTLAFFRNKEPLIYKGDIEDEDEVLSWLTDENTLEIPGKIEEVNARMLENILDENDYVVVFFYKEGDKKSQKILQELENIDEECEEKDIDFVKISDEGIEKEYDLPSLPALAFYRHKFRQVYTGDMMHEEQILDWVLDLRTSTPDVIESVDRKTLQVLINDVEHLAVFFYDDDCESCKEILEELETIDDDTDKHGIQFVKSKDAKLAAEIGIFSFPALVYYETGVPIMYDGNLKKEDEVLEWLIEQKSFSTNALLRKKSCLPGETAFSRSHCGNDNDDDDDDDDDDDDNDDDDDDDRTRTRKSRTIPKIKRTVPKSKKPFDKRIIKKRIQDDSVEDKKNDDEEDEEDSEENDDDDDEDDDENDTKECKDDDDDDEDDDEDDDDDEDDDEDDDDDDDDDSSSSRAIKHFVGKGDGCFYIGMGAKSAKPTIPSYEPYQCCPSKVTRSTKVAKVSPVAGKPKLQHKTSSSSSSSKRPKITPTISTPPPSLKPINKLSAKDSRKTLQSASVRTSTATTSEKAKKEQAKAKKSKGFFGSGNYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES00</accession>
    <name>A0A232ES00_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013793</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KEAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002537">
        <property type="protein sequence ID" value="OXU21112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES00"/>
    <dbReference type="STRING" id="543379.A0A232ES00"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18458">
        <property type="entry name" value="BACK_KLHL19_KEAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000024">
        <property type="entry name" value="Kelch-like ECH-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047098">
        <property type="entry name" value="KEAP1_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF401">
        <property type="entry name" value="FI11917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU21112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="625" mass="69871" checksum="A711FFC9F17B5890" modified="2017-10-25" version="1">MRKKPASLMDDEDECLGQNGNILFANDAARAAAFDTTDEKDTCEETKGDLGDMTFCMTSYIKGVMKMMHIMRSHHMLTDVMLEVGSEIFHAHKVILAAASPYFKAMFTGGLKECEMTRVKLQGVCPTAMAKLVYFMYTGKIRVTEVTVCSLLPAATMFQVSNVVRACCVFLEKQIDPTNAIGIANFAEQHGCTDLYNKATQFIIQHFSQICQEEEFLQLSAMQLVSLVRKDELNVQEEREVYNAVLKWVRYNEEARGPKMEHILHAVRCQYLTPSFLCEQMKNCDVLKKMPACREYLAQIFKDLTLHKKPIVKERTPNAPRIIYIAGGFYSHSLDTLEGYNVDDKTWTEHAKLIVPRSGLGGAFLKGMFYAVGGRNNTPGSRYDSDWVDRYNPATDQWRPCSPLSVPRNRVGVAVMDGLLYAVGGSSNAEYHRSVEYYDPDCDSWTYIKPMHTKRLGVGVAVVNRLLYAIGGFDGVNRLNSVECYHPENDEWSMVAEMNECRSGAGVASLGQYIYAVGGYNGVSQMKSVERYDTESDSWEFVEPLPTARSALSVTVLDGKLYAMGGFNGITFLSTVEIFDPDTNKWESGVPMTSGRSGHASAVSYQNCAFNCEHLDNANLQKAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESG4</accession>
    <name>A0A232ESG4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002425">
        <property type="protein sequence ID" value="OXU21295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESG4"/>
    <dbReference type="STRING" id="543379.A0A232ESG4"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU21295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10625" checksum="8DDD11609D1AE59B" modified="2017-10-25" version="1">MQPSEYQRARHLLLVRSRVANLRDSKNPTLRTNFIIGAITPGRLATMTAEEMASDEIKQLREQFKKEAINDAQLATVQGTKTDLLKCGKCKKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EST1</accession>
    <name>A0A232EST1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_015385</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002379">
        <property type="protein sequence ID" value="OXU21414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EST1"/>
    <dbReference type="STRING" id="543379.A0A232EST1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU21414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="456" mass="50985" checksum="C8CC89A3F42C1FFD" modified="2017-10-25" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGAYHGDSDLQLERINVYYNEATGGKYVPRAILVDLEPGTMDAVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQMTHSLGGGTGAGMGTLLISKIREEYPDRIMMTFSVVPSPKVSDTVVEPYNCTLSVHQLVENTDESYCIDNEALYDICFRTLKLTTPTYGDLNHLVCATLSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFIPGFAPLTSRGSQQYRSLTVPELTQQMFDAKNMMAACDPRNGRYLTVAAVFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPSNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGETHRLLSHIGMDEMEFTEAESNMNDLVSEYQQYQDATAEEDADFDEDEGENEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESX6</accession>
    <name>A0A232ESX6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002362">
        <property type="protein sequence ID" value="OXU21460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESX6"/>
    <dbReference type="STRING" id="543379.A0A232ESX6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000098">
        <property type="entry name" value="Transcription factor LBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051892">
        <property type="entry name" value="LBX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336:SF8">
        <property type="entry name" value="LADYBIRD EARLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336">
        <property type="entry name" value="TRANSCRIPTION FACTOR LBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="15870" checksum="D6B227E447E19260" modified="2017-10-25" version="1">MTRRLIKPFSFAEQANHLNLFNNRQQPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAAQLGLSNAQVITWFQNRRAKLKRDMEELKKDVQTVNPLLVAQHHKTFLENVQDLGMLKKRPLPSSMDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETG7</accession>
    <name>A0A232ETG7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002278">
        <property type="protein sequence ID" value="OXU21643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETG7"/>
    <dbReference type="STRING" id="543379.A0A232ETG7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="8565" checksum="E467C2019B9ECF84" modified="2017-10-25" version="1">MADNEQKAMQLIAEAEKKLTSKGFLSSLFGLKIVSPVKYSTISVFSDIFWHGELHLGTYAIPKSDMYIQCVYRVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETY3</accession>
    <name>A0A232ETY3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002205">
        <property type="protein sequence ID" value="OXU21811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ETY3"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05528">
        <property type="entry name" value="Bromo_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="935"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1058"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1120"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1220"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1221"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU21811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1344" mass="153723" checksum="A00C0BC375AB3B0B" modified="2017-10-25" version="1">MSDDAMDSMDAEDTEEEIFENPRKAHLQGTQTLKGYPMYKQHDSSSDKEMVDEEPPRTQRLSRRMTIRSRENHPPNKAPSRHLRDHSNHNSSRELRVRPHRLRERSDRDRDRSEHDLHERPDRERALRERPDRERELRSRPQQRGRGDHDLRDRNDRDIDLRALKERQDRDRAERDLKDKMETNDKSDSKTTNNEKESRPRKSDSPSRSREGPVTRLSNSCVEKDEKIKSESNDNNGKDEKNDEDDDEDEDNSQESEKAENNDNSENDENEGYEDMYTRIKRTRRTSQRVLQKRQMTVEDSDMSESSYTPGLRKYSLRQKKPTVDRFQANVEPVRRSIRAFRSVLSNSMRRRKHRSKSSSSTDSSDSEPQCYDKKKSKKSRQSAIPQGGPTDKKADISPISVDTDITFNDVGGLESHIHCLKEMVVFPMMYPDVFERFHITPPKGVLFHGPPGTGKTLLARALANECSQGSRKVSFFMRKGADCLTKWVGESERQLRLLFEQAQQMKPSIIFFDEIDGLAPVRSTKQDQIHASIVSTLLALMDGLSDRGEVIVIGATNRIDAIDPALRRPGRFDRELFFPLPAVKERLDILKIHVKKWSNPPTEDLMQSLAEKATGYCGSDLKALCTEAVIQGLKRTYPQIYLTSNRLLLNPARVEVKKADFVRASSLLVPSSHRVTPCIGRKLAPFIEPLLGSSLQELLGTIRKIFPQGINQELAKLKVTKGIHRPRLLITGGSMARNQGPQLAQAAIYQMEHLPVHSLNVSTLFAESARSPEETCVQVFNEASRNIPSIIYIAAIDQWWPLVPETVKAVFLCRIASLDPSTPILIIATSGVTYEELPDQLKSLFSALRGEIHSICSPTEEQRTKFFKPVFTVQSLKPPQIKKKNIEELEELPLAPDPEPKKLTPEEQKILYEKEEISLRELRIFLREICAKLARNRQFFMFTKPVDIEEVPDYNEIIEQPMDLETMMTKIDMHCYLCARDFLDDIDLICRNALEYNPDSLRDRPSLGLIKRDPADKLIRHRACSLRDNAYALIKAELDSDFEDKCRTISKNRKIQRNGVNRKKESQKTEPFNASEKSDRREGSAGSAIVVNGKKLPSSRKRRLHAWARGFVKKVAKKKKISFDDSTNNENSSSKPQEVTTTAAASETSAQGIDLEKFQEFESEAHCVLNGHVPISDHTDTDNDSQNESTRDAQLNHFADADKNVPEKKNVINNEVESMDVSHGEVEKSVENNVSNSSSRRESLNAEDLSFAVDSDSSLMNNPQESDKVMIDRIELDKVFAYTVKATEMFPIELLCDVYVQLSRSVGQYARTYDRKSLPKDLLKDVKIFEKYKIGENESVMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU60</accession>
    <name>A0A232EU60_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription and DNA repair factor IIH helicase subunit XPD</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CXPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">DNA 5'-3' helicase XPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DNA excision repair protein ERCC-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">DNA repair protein complementing XP-D cells</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Xeroderma pigmentosum group D-complementing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSAR_012670</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">Alberta</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="NNAY01002165">
        <property type="protein sequence ID" value="OXU21893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU60"/>
    <dbReference type="STRING" id="543379.A0A232EU60"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035315">
        <property type="term" value="P:hair cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="24"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OXU21893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="777" mass="89374" checksum="9EA8F13D911F763D" modified="2017-10-25" version="1" fragment="single">ISDLYFIEYNSIPLPLYYRISVDGLLVYFPYDYIYPEQYAYMLDLKRGLDAKVGHCLLEMPSGTGKTITLLSLIVAYMLEHPHQVTKLIYCSRTVPEIEKVIEELKKLIDYYEKETKVLPKIIGLVLSSRKNMCIHPEVSKEREGKIVDSRCHALTASYVRERHNYDESTPVCGFYEAFDIEGREMMMPPGIYSIDDMKEYGKDRNWCPYFLARYTIMHAQIIVYSYHYLLDPKIAEAVSKELAKSSVVVFDEAHNIDNVCIDSMSVKLNRRTMEKSCANLTLLEKTVAEMKEDDANKLKDEYNKLVEGLKDAQVARETDVVLANPVLPNEVLEDVVPGNIRKAEHFVGFLKRFVEYLKMRLRIQHVVQESPVTFLRDVQAKICIERKPLRFCAERLASLLRTMEISDLTDFSPLILVTHLATLVATYTKGFTIIIEPFDDKAPTVHNPILYFSCLDSSIAMKPIFDRFQSVVITSGTLSPLDMYPKILNFHPVIMSSFTMTLARPCLLPMIVSKGNDQVAISSKYETREDVAVIRNYGQLLVEFAANVPDGIVCFFTSYLYMESVVAAWYDQGILDQIQRYKLIFIETQDAAETSLALYYYNKACDNGRGAVLLSVARGKVSEGVDFDHHLGRAVLMFGIPYVYTQSRILKARLEYLRDQFQIKENDFLTFDAMRHAAQCVGRAIRGKTDYGIMVFADKRFSRIDKKSKLPKWIQEYLTDNLCNLSTEEAIQICKRWLRQMAQPFSREDQLGLSLLTLEQLQNREQAKIEEQAQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU64</accession>
    <name>A0A232EU64_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002164">
        <property type="protein sequence ID" value="OXU21898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU64"/>
    <dbReference type="STRING" id="543379.A0A232EU64"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10228">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000495">
        <property type="entry name" value="Heat shock protein 4b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="798"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="812"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="831"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU21898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="859" mass="96747" checksum="78FF702CD2DA0FB3" modified="2017-10-25" version="1">MAAMSVIGIDFGNDNCYIAVARAGGIETIANDYSLRGTPSCVAFSGKNRILGVAAKNQLVTNMKNTIYGFKRLLGRKYNDPFAQKELQSLPYRTSQLADGGIGIHVQYLNEDHVFTPEQITAMLFTKLKDTSVTALQTAVNDCVISVPSYFTQAERQALLDAARIAGLNVLRLFNETTATALTYGIYKQDLPPPDAAPRNVVFVDCGYASLQVSICAFHKGKLKMLASAADSQVGGREIDAILADYFCKDFQARYKIDARNNPRAYVRLLTEVEKLKKQMSANSTKLPINIECFIDEKDVHGDLQRADMESMCAHLFKRVEATLRQCLAQSKLKLDEIHSVELAGGSSRVPAIKRLIEEVYGKPCSTTLNQDEAVARGCALQCAMLSPAVRVREFSVTDIQPYSIKLTWDASQGEAGEMEVFEQNHPIPFSKMLTFYRSSPFTLTASYSSLPPAYPSTQIGTFTIKDVKPNKEGESSKVKVKVRINLNGILTIASASLVEKREQTQQEKEEEEQQQAQEANAEQQQDKKDKTDQDAEAKEPPAPEVKMDKLRRGSDDEDEARSSSYSSRIKTALSWFSSGDEKGEDGKNKVKVRHIDLPIDIRGHGLTQKELDHALERECKMVAEDRQEKERVDARNALEEYVYDLRSKISEEDQLYTFILDEEREALCRTLDDTENWLYEEGEECQRQVYSDRLARLRSQGEPIKDLKIEFEGRGPAMDEFAGALQLAKKGIDRIRASQNKGEDKYDHISEEEIKQVERTVQEKWNWLEDKRVQLNQTPRTQQPPIYCNQIRTEKQTLDNAVNPILNKPKPKVEPPKDDKKDKTGEHKNQNSQQGHNQNNQSGNDDKMDVDSSAADME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU83</accession>
    <name>A0A232EU83_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002165">
        <property type="protein sequence ID" value="OXU21894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU83"/>
    <dbReference type="STRING" id="543379.A0A232EU83"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="655" mass="70695" checksum="661F4D695077B8A5" modified="2017-10-25" version="1">MSKNFGETTNGTSSNDSIIPNKSCHSEDTPIRGKELKKASKKKLSRTTTKPRLSGGADDGPEDDVPGTNKAVRMNDSSMGGPQDNTAGTNKSVRMNNTSMGGPEDNTSRSGPVDNSRSGPVDLHSQSGPVDLHSQSGPVDNSRSGPVDNSRSGPVDNLRYNGPEEHHSRSGPVDHQSRSGMEGPVDLHQSRSGMGGPVDLRASTPSRSVDNRGRGTPIRSGLEGPEDNVAYEGPVDLYSGQALPSTGRKKSFDELVLFRDPRVDEMLDCSLHNLSEANLALTSLSENLEHELKLSLVELMNRTRKWTSLVENKIEWSRKDILNLHQELAKIMASLKESRRESSMLRDQLTSSEAANKSMADSSMNEKMRNGQKFDNTGQLLAVSGLPSAQSTGHDQQHQSAVPSAVRSAQLEHQSAGLISPRSQSRSRIMSAALAKQTPGSLSPPELATVHAEEERLQSCCAELEAEVQELRKENERIVKERAEYENAIQRALLKGVSSLNVEALKVLRCSPIPNCCTPCPPSSTIEPVSKPRDCSTPLHCGGTKSSNANENKACNNGRSVTAASSACRSHNGSREALYSGNGNGRRVCPSAGHHQEHKQRKSRDNNMLLLLHQKDAECYGIQTGSNCCDNAAKKSSAYASGNCGKHNSKSSYMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV41</accession>
    <name>A0A232EV41_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_007101</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01002054">
        <property type="protein sequence ID" value="OXU22224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV41"/>
    <dbReference type="STRING" id="543379.A0A232EV41"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17958">
        <property type="entry name" value="DEADc_DDX43_DDX53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076493" description="RNA helicase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="751"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="938"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1164" mass="131919" checksum="402917F9019293EC" modified="2017-10-25" version="1">MATMLLWSLLALILTAGPEVEAKPPPLRPPRLLVISYDAFRYDYFERDFTPFLKQLKLKGTHADYMRNVFVTKTFPNHHTISTGLFVESHGVVDSEFYDPKTNRTVNYSDELFHYNNDINPIWTLNEIGGEGRYSGVMMWPGSNFKYHGTHSTFTVPWNMSVPWTERVDQLLSWFNHPKTPINFGMMYIEEPDFHGHGIGINHPRFNEVLKKLDYVTNYLHDKLKEKCLTDVNVVHLSDHGMATVTLDKIVNLTNYINPADYKTAGLSPVISIFPNPGKENEIYNKLKKASEHTKEFDVYLNNEIPARYHFSKNPRIGPMVVIAKVGYSFEGLYDSFPWYEKEFNITINEKSEFGLHGYDNNATEMHPFFFGVGPAFLPECKVPPFDNVDLLPLFCEILDIQCPQVNGTVGELRNCLTKHQYEAVLYKGIYIGGIVISILGIIALFLVYLRRKRIAKHNAKYRMDEDWDDDSSQQTYQAQSSNSYQQGGYEQRNRNNFRKPRDDHHNNGRYNNRDRSGGSNRGDRDGRREQDYNRNSNEEDDERTTFFVETSKLGKVIGKGGSKIRELEEQTGAKLKINKDCVNGDATAVIVSGTKDAQDQVKTLIDELLSDQRPDRPFTINTMNSQECNNVRNDDRRSAPIDWDAAAKEHDQYQAQKWEKYGSIKKNFYIEDPEVARLSKSEVEKIRKDNNDISVDHTFDVDPSQADSEEYKIPNPVQTFEQAFRNYPDILVEIRKQNFEKPSPIQCQAWPILLSGKDMIGIAQTGTGKTLAFLLPALIHIDNQDTPRSERSGPTVLVMAPTRELALQIEKEVNKYYYHGIKAVCVYGGGDRKKQMNIVSKGVEIVIATPGRLNDLIQTEVLDVKCVSYLVLDEADRMLDMGFEPQIRKSLLDIRPDRQTVMTSATWPPGVRRLAESYMKSPITVCVGSLDLKAVHSVTQRIWIVDEEEKTDVLKEFFHNMAPTDKVIVFFGKKSKVDDIGSDLALSGVACQSIHGGREQADREQALEDIKTGDVNILLATDVASRGIDIEDITHVFNYDFPRDIEEYVHRVGRTGRAGKTGESISLVTRRDWGMTKELIKILEEAEQEIPNELYSMAERYEAMKKKRDEERGDGDRRESGGRRYGGGGGGGGFRSGGGGGGHGYGGGGFGGGGGGRRGGSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV65</accession>
    <name>A0A232EV65_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002051">
        <property type="protein sequence ID" value="OXU22239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV65"/>
    <dbReference type="STRING" id="543379.A0A232EV65"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000300">
        <property type="entry name" value="THO complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001007">
        <property type="entry name" value="THO complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25174">
        <property type="entry name" value="Beta-prop_THOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU22239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="552" mass="62048" checksum="6D0D97906B4C93BF" modified="2017-10-25" version="1">MAPQSSVEELITYFKTHNKVREQQSHTAKVHSVGWNCDGKLLASGSFDKCVCIFSLSPDRLKLETTFRGHGGSVDQLCWHASNPELLSTASGDKTVRIWDTRTQKCTANISTKGENINISWSPDGNTIAVGNKEDLVTFIDARAMKIKVEEQFNFEVNEISWNKDSDTFYLTNGQGCVHILSYPSLELLHVIKAHPGTCICIEFDPTGRYFATGSADALVSLWDADELCCLRTFSRLDWPVRTISFSHDGRLLAAASEDLVIDIGEVESGEKVTDIPVEAATFTVAWHPKQYLLAYACDDKDNYDRKRDAGSLKVFGFPNEKNVLSSGDYTKNEVRTKVNTRRSMESKIAGEGDGKINTLKSDIEEDTADIESAYDDSFCSDNSDDDSELTGASHQSSLSEIPSLQLTSPKTLLKKKDLTNLNKKFVSTSKIWDDPPLTLEDKAKSLSLNEVRPHRNVQFRPNRKNMSFTNDQIMKIERDNEILLRKIMAQQKSQKQKVQPPQSKLCSSAINRKKLQRKIEEDNMMLLRRLQQAKSCALNTNKIPGFRTTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV81</accession>
    <name>A0A232EV81_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002042">
        <property type="protein sequence ID" value="OXU22245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV81"/>
    <dbReference type="STRING" id="543379.A0A232EV81"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="125"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="335" mass="39783" checksum="9465D01A4A19772C" modified="2017-10-25" version="1">MKVKKDLVVNPLSRTKQKKVKDEDGKEAKEVIMPRETGINHIKCKVIRQKKNAELQRQKKKEKKERRKARAQTGEPKQVPHTIESLREKDETMIYGEIEDEDNEEVKIDMEHDEFAPYYRQEYEPKVLITYADNPHTKTRIFGRELTRIIPNSTSLYRNRSGVKKMVKSCIENGYTDIIVINEDQCKPNGMLIVHLPDGPTMHCKLSNVKITPELKRSHKEITNHRPEVVLNNFTTRLGHSVARMFGAIFHHQPEFKGRRVVTFHNQRDYIFFRHHRYEFNPKTGKPRLRELGPRFTLRLRSLQHGTFDSKYGNYEWIIQGRRHQLETSRRKFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWL7</accession>
    <name>A0A232EWL7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001853">
        <property type="protein sequence ID" value="OXU22725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWL7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="159" mass="18320" checksum="8B95D6FD8F6DB8BD" modified="2017-10-25" version="1">MDLRVSQTHKVVEKNQREDLKILKELGNIEEKATFFLKVPELRLGGESLGSRTISRENLASMVSARSMDSTSSITRIADYRKAQQEAIEVRKEEKDYITKLEKKVGELIEDCQSAPKDVKRTAERAKQLKVLSIQSRKKHEKGNNKDARYEGDVDYYQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWU3</accession>
    <name>A0A232EWU3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress-induced-phosphoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001821">
        <property type="protein sequence ID" value="OXU22816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWU3"/>
    <dbReference type="STRING" id="543379.A0A232EWU3"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="9">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="9">
        <location>
            <begin position="494"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="545" mass="61855" checksum="A8DF7EE2CA584619" modified="2017-10-25" version="1">MLKDLGNKLLAENKLDDAIHIYTQAIELDSKNHVLYSNRSAAYAKAGKYDLALQDAEKTVSLKPDWSKGYSRKGGALAYLGRYDDSIETYTKGLLLDPSNEQLKSGLEEVKAQKNSQSQFNSQGAFPNPFGGADVITKLRNDPRTKAYLDDPEYMKMLDNLRTNPKALSSHLHDTKVLTTLSVLLGLNDDMDMSMDVDPPKYEEKPQKKAEEPKPKPKEEENLSPEKKQALEEKNLGNAAYKKKDFEEALKHYNKAVEIDPTDITYYLNIAAVYFEQKEYEKCIAQCEKAIDIGRENRADFKLIAKAFTRIGHSHKKMNNWKQAKVYYEKSMSEHRTPEIKTLLSDIEKKIKEEERKAYIDPVKAEEEKELGNEKFKEGDYAAAVKHYTEAILRNPDDPKYYSNRAACYTKLAAFDLGLKDCEKCVEIDPKFIKGWIRKGKILQGMQQQGKAITAYQKALDLDPSNAEALDGYRSCSVAVSSNPEEVRKRAMADPEVQSILRDPAMRLILEQMQNDPKALQDHLKNPDIAAKLQKLLESGLVAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX46</accession>
    <name>A0A232EX46_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001796">
        <property type="protein sequence ID" value="OXU22893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX46"/>
    <dbReference type="STRING" id="543379.A0A232EX46"/>
    <dbReference type="OrthoDB" id="6577359at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19195" checksum="ECD775D4D5899B5E" modified="2017-10-25" version="1">MDSFHLLMTLINQHSPDDDQPDLDMLKNLPVEISQTILSKLDSDSLLNCALVSRKWLSICKSSRSLRQKVRLHIRSKENVRIINQSITNAPSTSNHSIHQPNHDTYRPSYRPMPPPTNNRSIVIFDDSSISNDTNPTSSTPSVSQQPPSQRRRSTSTKCLLKKTSCLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX73</accession>
    <name>A0A232EX73_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001765">
        <property type="protein sequence ID" value="OXU22974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX73"/>
    <dbReference type="STRING" id="543379.A0A232EX73"/>
    <dbReference type="OrthoDB" id="8175398at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="723"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="758"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="791"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="824"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117802" checksum="24F4FDC9FDADDEFE" modified="2017-10-25" version="1">MATKLGIMQFIRAVRQGDIATIQNEIRRYGLPKGGSVYTDYTALQAAFECRRYEIAKLLISAGCRINPNQSDKGSIPLMKAVYYENNELVEMLLERKANITSDNTTVLHLAAERRLLNMLQLILSYNVDVNAVNSSGNTALQSIILRFTRFAIPHLAPLLTAVDIAIIQLLLSKGAKIEFKDYNGVNPLHFAVKLNDMKVLQQFVQACPDVNVTDKDGNTILHILVSMTNMNSQSEIGILGVVKMLIHKGARIDIANKHKENVSHLAAKYKKLHIMKIIPHNETTLNETDSEGNTVFHLLFENSLSFVKDQEFMSVFMHLLSLGIIIDTTNSVGKTPLQLAAENRQDQILHILLPYANTVDLRDNQGNSLLHCYLQSIIDYGTTSCEDNLAIVQILLNKGAEVDATNVKGISPVHLALKLRDRDIVLELLERINNADLCDIKGSEIFHRALLHFLAANKYKSRTTSNSPKNPQESIEIAKKILAKNATIDKRDNRKRTPLHVAVTSRQSGLVQLLLDHGADPNAVDEQDENALQFLVNSQSDQPEDLDVSIAEMLITKGANVNAVSKENLSLLHTVARKRRMKLMQGLLQHCSKEVISLKDHQGNTVLHILMGFNKPRSDAELSNLCIDVAMKLLTEAGDMLVNEPNARGETPLHLAAREKHGLMLQILLLDGADPFIRDITGNTVLHSLASSQSSQNQSNIEEQIVEIFVKKGCLIDAMNQAGLTPLHVAIKNVKNAKVVAALVARGAEIHRTVGENLSTALHLSVECDNIEVANVLLRNGSNVNAVQSNGKTCLHLAAARKSFKMIKTLLDNRADPDVQDLSGNTALHLACWYDDFETATQLLDYGADINIVNSKGSTALLFSQGADNALKSKLLHYGWKLRKANLPLASSNLEYIRKSLVQFHMNSSIYDEELLEMERYQVDARTNVADVLRMPASRLVVYKAKLKFRQLIFEFEELAQKFPHYADIIRANYRKGIARSELECSAKKAFNALCQFIWPDICCEKILRNLNNEQLRSLIKASNLKVNNKKRFLRDLDEEFERPAKRTRRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX80</accession>
    <name>A0A232EX80_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001790">
        <property type="protein sequence ID" value="OXU22918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX80"/>
    <dbReference type="STRING" id="543379.A0A232EX80"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325602" description="Lipase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="433" mass="49083" checksum="521E7DE9E60F347E" modified="2017-10-25" version="1">MTSLRIFVSAIALLAASVVSSKVAPEALDVLNEELQDLDFPEAFNLTSSDLVLRYEHPHANMNVPEIVAYYEYKVEKHTIRTTDGYILGLHRIAGNKTHPKPDGKPAVFLMHGLLCSSMDWVVAGPERGLGFILADAGYDVWMGNARGNKYSRRHAELTTDDAEYWNFSWHEIGTKDLPVTIDYILKRTGHKKVAYIGHSQGSTAFTVMLSEHPEYNEKITSMYSLAPISYLSHMTSPVFKTLARLMPIIDVILGLIGKHEIDPSSEFFKKFTGIFCEDGSITNPVCTNVIFLICGYSEELLDKELLPAILAHTPAGSSTKQFTHFAQLVNSGHFRQFDHGWWGNFKKYSSFTPPSYKFENVKVPVALHYAVNDWLSHPKDVEKIYSKLPNPIGKFRVPHEKFNHLDFVWAKDVKTLLYNKVLSLLARYHHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXG1</accession>
    <name>A0A232EXG1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001761">
        <property type="protein sequence ID" value="OXU22999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXG1"/>
    <dbReference type="STRING" id="543379.A0A232EXG1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475">
        <property type="entry name" value="ZYGOTE-SPECIFIC CLASS V COPY B GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475:SF1">
        <property type="entry name" value="ZYGOTE-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325597" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="7894" checksum="3CF0651802D68DEE" modified="2017-10-25" version="1">MEVKSIVLLLLLIQFASAGPIGAGICYAGCAAVTCACFAAAGFTFGTVPATIIAATPALAACNAAFATCEAACVAALIAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F024</accession>
    <name>A0A232F024_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_010677</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001399">
        <property type="protein sequence ID" value="OXU24106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F024"/>
    <dbReference type="STRING" id="543379.A0A232F024"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="14">
        <location>
            <begin position="41"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="13">
        <location>
            <begin position="180"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU24106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="472" mass="51051" checksum="9B2D530F556F2E36" modified="2017-10-25" version="1">MTLARSLLSARAYLPLLSSLSLYCRTLTLIFKRSIQSSMPIQSIKARQIFDSRGNPTVEVDLLTENGLFRAAVPSGASTGVHEALELRDNDKSQYHGKSVFKAIDNINKIIAPELLKAGIDVTQQTDIDNFLLKLDGTPNKSKLGANAILGVSLAVCKAGAAKKGIPLYKYIAELAGNNDIILPTPAFNVINGGSHAGNKLAMQEFMILPTGAKNFTEAMKIGSEVYHHLKNGIKKKFGLDATAVGDEGGFAPNILENKEALNLILDAIKVAGYEGKVKIGMDVAASEFHKNGKYDLDFKNEKSDPATYLEPSALQDLYLGWVKDFPIVSIEDPFDQDGWDSWASITAATPIQIVGDDLTVTNPERIKTAIEKKACNCLLLKVNQIGSVTESINAHKLAKSAGWGTMVSHRSGETEDTFIADLVVGLSTGQIKTGAPCRSERLAKYNQILRIEEELGAGAKFAGEKFRNPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0V2</accession>
    <name>A0A232F0V2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001328">
        <property type="protein sequence ID" value="OXU24345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0V2"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU24345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="667" mass="76593" checksum="C356DEF7B8B0214E" modified="2017-10-25" version="1">MHRVFIIMSFFSLSGRKINYDPDWKGPLHKRSCTDCFWLILFIIFLVGWSGVAYYALKHGNMEKLLHPSDTEGRKCGIDSAVKDKKYLIFFDLSKCARISTEYRSCPTTQVCVEKCPDRNFLYNNARETLPLAELKRQLICKIDVKLNEIYRLDQIDKLVKAEKCASWYLESTSIVGRCFPKGIWPEFVNSTITVPDLQHAEAFVKAVANIEDVLKKVYQDIKETKYIVLGIAIASGFVSLFYIVVLRWLATPCVWLTILAVCASLGYGTYETTLVYIKTRYTEWLVLLVIVATILFLIILATLFLRRRIYLACQLIKESSKAVTCVLSSLIFPVVPWVLQLLVLTYGVTIFLYLLTIWSPNYRVEMMDDNCICDSSLHYVNNATCDPGIFNANCKQSGGPCILSACNLVGKDRPWFIKYFHIVNIVGFYWLFFFVSAFGEMVLAATFATWYWTLNKHNVPYFTITVGFWRTVRYHLGTLAFGALILTICRIIRLILEAINEKVKKANNECANAVMCCCRCFFYLLENFLKFINSNAYIMCAVHGKGFCRSARDAFNLLMRNVIRVVVINKITGWLLLLGKLLITGLTVAATWWYYTNKGKDDVFYWEVPAVMTAIASFLIATVFFKVHAAAIDTLFLCFLEDCERNDGTDARPYYMSKRLRKLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2C4</accession>
    <name>A0A232F2C4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001239">
        <property type="protein sequence ID" value="OXU24640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2C4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="11641" checksum="C1D878CA0C9DB41D" modified="2017-10-25" version="1" fragment="single">ERKGKRFLEEPAPPDKGRERVTASSSSLRRAAASSDRRTLFPIALSVLTRPISRLLLRSASRRAKAPEMTGTAAQKRRSSLKIPIQSHESKNILTTYFILLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2R6</accession>
    <name>A0A232F2R6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001172">
        <property type="protein sequence ID" value="OXU24882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2R6"/>
    <dbReference type="OrthoDB" id="9884296at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17685">
        <property type="entry name" value="RUN_RUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF13">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="RUN" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1460"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="665"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="740"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1311"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1322"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1519" mass="169416" checksum="80C4AE49CCBEEA8A" modified="2017-10-25" version="1">MMEDPQTPGSDCNSNPANDPQDFVGSEFIQDNMDYQWFIDYRAHSQEAYCTSYRDGGLHVHPSVLSSLSASYTKDDLGYYDDLARNLDANLAEVDMESFRTADIHTLLTALPVMCTDPVQHSEFNYQRERYASISGSVMEKLDISSSISPRASSQGEDSACSTTDTISICKSSLLFSPVKEMPVLPPGGSYSVDSLDCEDMLITCQTNNKNNYTIAFEGSIAMYSDGSQDFDNQEKQKVYEVPTDSYYDKTLNLKNMLDLSMACSDSKIYTTWSNLKHSSISKAITRHPSGNNNTTPNFLQSTGSGTSNATSLPVVSNKSRSQSLPDLSRAREIERVEMPLNFSVDSGETSSRSGRLQSSGSLMSRSMNEESSDSVGNTFSSNKKLQNMSLVRLFMKQKSMSTEGMSLTLDQTDSGSETGWPTSSNSESGTHVTQIHKQHNQLQHTQNNLSVPDNDLAIKWVKADNYDIPKRSNCSTSMEDLLNTSRSASSIGRDVSMKTKKKEVCTKTTTGIQVMTEVEDNGVQTSLIYPPLNNSNKESGNYPFRETVVNEKPVYVVYPNYTLPDLSFLNSTETRFDNVALKPQVYGKRSGKSGRPFSCNDIDALKQRGFSHVKDWESLTFLLPNEYRKILHDVPEVSKHVKMVGEEARKPLFCLSPPMRHRKRTLSDMIPNTVASSSSSTATQPSSGYRGSSTILTDSSSNQQNSSNAGLGNNNPLYLYRYDSVSSEASLHGQEKLLTNSRQPTQYHYRQGAPSLPKRSISLPQASDCGSAPPRPPLPRSILRKNRAAAAAAGKRCSMFEMGQVNEIETRHGMSQENKRMSLQEPYYMNNDLQLLRHAGIVDSEKDIDEAEERQRFDRLRGIDNDDLESSGEDVKQLEEFLRRSGFSSHSSDGDTGMEHDDIKLRSCVRRFLALKMNQDMAKMIDMADSQKKTVSFAVNGKPRYLDEKTNTMDEKERLNVSESADTNFELRPIDLEDKKKMIWSVNKAVDGLLKFWHSEPVRSRQGYNDKNECSQLCLGQLCPALYAVMSDGLKPQLNSTFGPIANSVWQVVEASSQQGPLTKTLNDLVQKINGEDFMTEGMLKFHAFVFGLLNLRALDAWFAYLCTRESILRKHYNNNSLFVGALGCANSREVIDAFLNILQPLAFCPFQLDLLYQYRQLHNSFGQSNAINLEPVTVTPTKKSSERGQRPRSCVLYDNSRQQYDGEKRADEEIKKRWSHTPLSAKFHVFDRLDDSEDYTDSLEHSPLNRASPKKTVSKQQSKLPESRDSKSRKDEDHSAEAAPAGENKFRKLQEKWEHLGRDDTSPKEPQPPTTPSPSSPTRTPTSNLSKSRIPRLLTSPVKTPSNLPIPVKSAKSPSGIPSLKKPSGIATTTKPRTTTGNNISCKDSPRRTSRLDQESTGTPRAHLTRPSSLPYKTGYGASAKEKSTVSPHRRAASTSLPRPHSIAAPPRNLPPKQAPKFVRTLTSKPQSVDGHLSFNEGDKLKVILEVDGKWLLCARGERKGLVPRSCVRLILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2U4</accession>
    <name>A0A232F2U4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_000076</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001205">
        <property type="protein sequence ID" value="OXU24747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2U4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2425"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2458"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2497"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2580"/>
            <end position="2598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2604"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2634"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="388"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="528"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="832"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="911"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1384"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1461"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1604"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1946"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2080"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2206"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2274"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2736"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="849"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1384"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1407"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1476"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1499"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1542"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1604"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1651"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1714"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1958"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1971"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2013"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2024"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2037"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2054"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2210"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2247"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2312"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="2745"/>
            <end position="2755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2852" mass="319697" checksum="9B7E7E3D902E866D" modified="2017-10-25" version="1">MPRKENTKAKTWERDRRNRMNEYFKNLSDLLPPHLEGRKRNKIDILVHASKYIKDLHSRTDELFYARASDAHKEELARLKKLVAQLISRTQLLSGLLKDAGITVPAEPALERISPLKWSNKINVVPESQIAEKVETNAGREKKKEKSSASLRTNLKKKAIKVKMAKKQPVRKKCFPEKSKRIIEDQENHATSGSSDTSEKGDKSSSSNEELALSTTSAEASPPKPEIKNHKKVKRKKKVAKKDKKTKGTTDINSFAAGTYVLSGGKIVPMVTPMQCNVTPNIIVNAQSHPPNPIILNNAQPGQMIVVQPLQTNHFQTVSTMQTLNTVTLNTMPNIQTNMLINSKDWPKNVKSIVNSTKIGGTKGILPKIKEVTETTMTYKVPIPAIRKEKSDSKAESKESASVDKQTKGKDVSKAVNNSRLANAETQKDSQNSKDDDKNNSSKTKSPVNKPIKRNSKPNSKEVVETKKKKLSKNENQVTNLQIESNIILNDTVTCKSIENLKQVISKIGEDSSYSAVDNSVEIREEQECDNNLIKDSNKISLTNDEPEEEKTDSQNEFSTDEKAANLNNSNNSNNSNNSVSSSEKELLNESNFTERTLDEAKSITEPKEITVEKRDDKITDSEKTDVQLASNCIIDDNMILANDANQSCSIETRLDNMLQSNAQNEIIDEQQPENNKIFLNLDTNTTMKLEGSEDKIHSVPPTSTSPFIKVTTEDESLKSKNNIKEDQNLLKTISYSPSNSFVPINHKTDSLHSDLSNDIFASLQVPSSSNNSESISPTAAFLMAFPIVSSLAGKTEVLDDEMKDEFKYSSQTPPMILQIGAIEPNNFKINTKNSTNDNLDTAEPTGISEPSQTKSSTETVTPITSSTSVAVPAKTLPRVISSQTITESYKIIPVSSEQINRQLNVDTNSSMQVRQNNSTNPSENSNVNNTLTNRDQSSVIADNIDRSIDNSVQNYPLENKSQSTFSYSKDMTLTSMSNSMANEILNKYISTTSLSTNTMPTETSSKYNSVSQYVPQECQTSVPNNCVKESVDRNSSQYSFPSDRDLCKLQICPMEAFTERSNEYSSYNKDNSFSNNPSVETNNESLNKNIQIPISQEKASKVSIQNNHNVASNNFHSIKKLESKGPPPTSTDNTALYHKKPNEIPNTNSYIGPCDNKISKKVMNVSSQPSTSVQKITVSSRSNVFMHQTEASYNVTTNFEENIVARSTTTVANNSSNFSILSWTTFSPLSSNNNNNFSQYDQTPVSTDISRNICENFNYHPLPKDNASLSNTLTQPTYSTVDSQMPSFDKSKNNNLNQPSYTTVDSHMPNFEKSKNNVQPSYTTVNSQMPSFDKSKDNALTQPTYSAIDSQMPNFNKSKSNNLTQPSYTTVDSQMPNFDKSKNNALTQPSYTTVNSQMPSFDKSKNNTMSQPTYSTVDSQMPNFDKSKNNLLTQPSYTTVNSQMPNFDKSKNNTLTQSTYSTVDSQMPSFDKTKNNTLTQPTYSAVDSQMPNFDKSKNNTLTQPTYSTVDSQMPSFDKSKNKQSTDNQKRPYNDPLKSRTMRLSQLDSRNPPMQKSTRAHNQPSVSNSDYKYASENKNKYKYPMDIDYMQNNYSSSLDLAPHLQHNQQQQNQQNQQTHQTSNSKSSNSNQQLQPLKSDKSNYMLPDYETHTSTNFNSDSANIQPRYSNSHEVYPSTSYKYASDNKPQQIHSKYQSTTQGPTSSLQQENTIYANNSNNTNGNNNSKQQHVQQQQQQHQPQSKAKSEHTMRPPVNWMMTPEIKHNSNISDIILPPIGKELDFCQNNIFSQTSGYNQTSGNHQFYNNYDMSTPSFPNIPVLQTDSKRNVDTTYYPEEQTFSWSPTKNLSQSTEQNQNLKNVESSTMPALVGDLALGTPNVSDKQNFLFGQMPIRTSNTEIGKEPLKSKETNVSSRDYQGIVNSQNPQQQSSHGMPFLSVSQLVDHEKVDKNQQQQTHNTGNHHHGSHHHPQHHQQPQQQQQTPPRKQRKSNSSPRASAKRQMDMRQKQSANSANDHIHRQHEEPKTSSTASGFGDTNYQQQQQQQQQQQQQQQQQKYNQQTNDTQWRNRNCKSNYTAEALIGTNNTDSSSHPEKNLPKYSSSNYTQNKFSTSLSSDPMSINYFPNVDEAGTGYGQVMNQNFNHSYAYSSNANIYPTSNFISNMSNSSANYMMSLHENTPDYLEGNNFLLPPNVSTTSITTPLLTNMTDGVKSHHHHHHHHHHQPYKPQNCADKRLYFGQQKKTKRKQETTSASSSATSTVQNFDFPGLSSPLDDYHHASTFLPPPNPLYQNQSYSKSTLPPPPPPPSVSSSNSGGNQASGVPASTSNPMAMTQHHPSGTSLTNFNLSTIFPEINDKEMRKTVVEDLDAMMSEVRQLKLAASEMQSSGANGTEDNRTTRRNGKLQDKVFVARNSYLTDLFEISHFRTIYNIFIVMLMILFLNTAVHDFIETGTTKEIKWKVVLTNFVEVLLVVFYVAFMFERFVIPPFDKFGSKILEPRAVVLTIFSLMLPGLIMFLFGFYTVLHTWQNCMAELLRFSDRLFYKDWWNCTSYDAYYRTWNIIVHDWLYAYIYKDVYETLHNKVIATFTVFLVSAAFHEYILAFTFQFFYPVMMLMFGGFGMLFVFITKNYSKMDGNIFIWFGLFAGNGIIFSLYSMEYYARGHCLPYEDPLFDLLLPRSWACRPSELNASAAASNNNDQPILHDEIRIRNPKPTDNRLVHEFVVDGLWGKLEIGDTDGGTAASTAGDTEGGGGGGSGGGGGGGGGVVFFLIGDDDAAKDIALFSGRLLTLPPPPPDSFGVEKSSSISAASCELVPLPPAEADEETGGIGVRVILAGVVILDSTYTRNKFIHYYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2U5</accession>
    <name>A0A232F2U5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001198">
        <property type="protein sequence ID" value="OXU24773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2U5"/>
    <dbReference type="STRING" id="543379.A0A232F2U5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="448"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="506" mass="57052" checksum="6D88F76EF4EB6D55" modified="2017-10-25" version="1">MDYSKEFNCTRGLRKFIAKKMLSVVSCKESPQKKRSKVQAQVVQVLEKTNYSLNVVNRYKENIVHVSAANNCVDVIKCILQKHVKHCLERKNSFGWTPLMQAVRNENVEMVKFLLDSGAIVNDFSFLAGLSVVSLACAISKEMFDLLYNSCPQALEYAAHDDINPLCVAALKNDKELFFHLIALGLDVRKANAFTHTIMKQSTDPQIAALAKNHLSSEDYWNDISQIEDYLNVESGNNSNNTPSPNAKNVQNTEQTCNANNCIPKICVEMSKPAIIKDVNNNKNNINLYLDLKSVETNCNSKSLISPTLSYVNKDVLPTTPNTFITEDNPVHAFSKLTLNVEEKSIKAKHNNIQTYMDKTEDAMTSPLVLRRCQNIRPPNLKLRHSSNDSNATLSFTPQFTPTKSPNLPKDINEDNVFDESTPTPPKYKTPPRGIILDPSTARLMFILQRFGLKRHIPTFLEQEVDLDLFLTLTDQDLLEIGIESKSERLILLSVINECKGKRNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3G6</accession>
    <name>A0A232F3G6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001154">
        <property type="protein sequence ID" value="OXU24967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3G6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234843" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13750" checksum="88CB5DA7F1C1C830" modified="2017-10-25" version="1">MARDCRFSATGMTMRLLLALALCAAFCHDNLNPNRRAVKMQDCRMKFYFYPRDANEVNYLRFVEKKKKKEEEEANSGCYVIEFPNKRSVNIHRMVRRRRAENYVDICKYPIADKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3Y4</accession>
    <name>A0A232F3Y4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001075">
        <property type="protein sequence ID" value="OXU25239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3Y4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="188" mass="21867" checksum="3A333E4235B8A01A" modified="2017-10-25" version="1">MDDIHDRQWSNGKFSKIREQKKRAHNPYKSSDILQIEERNNDKESCNVNASVNADVPMKTKQIIKARTRRVVRINLIKSELKEGYIPRIDVGNKDVFLREGVVINDNNTCKMVAINTSEHDVAIEDDARELIPFETEPEFLEETDIKDTGSLTIWDPYRNLCTIKKYLHEFFGGRIPDRTLTFTNIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4K3</accession>
    <name>A0A232F4K3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galactokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_010872</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001063">
        <property type="protein sequence ID" value="OXU25277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4K3"/>
    <dbReference type="STRING" id="543379.A0A232F4K3"/>
    <dbReference type="OrthoDB" id="275179at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000001">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000040">
        <property type="entry name" value="Galactokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="320"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45593" checksum="067748CC843021E5" modified="2017-10-25" version="1">MATIYPEVSEVKEKALQSFSKEFGVNADICVCAPGRVNLIGEHTDYNEGFVLPMCFQDLILKFDIECGALPMVTMIVGKKNNSTTCKIFSLSTSIGGQSVAEFNCVDREAMKPGEPKWANYVKGCIANFPHSTPGFNAVVTSTVPVGSGLSSSAALEVATYTFLEAMTGQVSSKPEDKALACQRAEHEFAGVPCGIMDQFISAMGQEGNALLLDCRDLTTKQIPMQKLDDCVFLITNSNAPHKLSSSAYCERRDCCIEASKLLGKKSLREANVNDLEADFLLHKFCSFSSVVLKSKAANEVTIKRVRHVITEIQRTLEAAASLEKNDFVRFGQLMNESHNSLRDDYEVSSKELDSLVTIARGVDGVLGSRLTGAGFGGCTVTLLKKNVVDTVIELIKKEYAGTPSFYIAKPSKGAQVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4Y4</accession>
    <name>A0A232F4Y4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_006047</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000969">
        <property type="protein sequence ID" value="OXU25672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4Y4"/>
    <dbReference type="STRING" id="543379.A0A232F4Y4"/>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF247">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012692056" description="Peptidase M12B domain-containing protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="195"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="755" mass="85550" checksum="179EB801870F154A" modified="2017-10-25" version="1">MNCVALLVALSVFQFAKPVRSNDEELEVVLLPIQWSSGNATVPLSFRAFGEQVDLLLEKNENLLTPNFEVWKRGSNDVLERKNHLENRSSCQYVYESSLSSAAVSLCDTGTVHGFVFLENDSLEITPLRSEDEDLFRKHRIQVRSTSYGEPHVIKRRRVSSHDRERVFDPERFRASPRRRKSSEPSSDKRSVSPLTIELAVFFDATAHRLFHPHLSRDDDKLLDMLLAYINNIQALYYHPSLGQRIELALVRLELMERQPKDLAHLDGERGQLLDTFCAYAKKLNPAGDDDPGHWDMALYISGMDFYAMEDGKKNPITMGLAPVGGVCWDEYACVIAEFGVTNRFGKPYPSAGFTSVYIAAHEIAHNLGMHHDSTGNSCPKDGYIMSPSRGVQGETHWSSCSREVANALGSSKRCLLDRPRLDYRLQPNRHLDHSGRFSELPGRHWSAKRQCELLLRDRKAQVDSLKDCCKALRCRTPNREGFYFAGPALDGTSCEKDKECRAGDCLPVEDKWEALPPLTTPSPGASGWSDWREGVCESGCIRGSLGYQERRRICLGESSCPGSNVDVILCKDAHICDRGSRKRLDVLEFAGQRCLEFAEKLDEIDGVAGGLQAGHEELRPWMACAVFCKRSDIASYYTPRLELNDLGMDPYFPDGTWCHKDEEGVDYFCRRHHCLPENFRFGKGLTTDEKEEEDLLGPMNARPKLRPEVVRYLSLDLNGKPLLGSFEPREEDEDAWLDTKDYVELPDEFLARFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F513</accession>
    <name>A0A232F513_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_012354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001028">
        <property type="protein sequence ID" value="OXU25427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F513"/>
    <dbReference type="STRING" id="543379.A0A232F513"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="229"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="638"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="91064" checksum="8F23536CE5A1BDF2" modified="2017-10-25" version="1">MNGLIRKGLVWWNEELKEKKREVAKEKKKYQKEKRREGANVREKWTEWKTSVSEYKEMMNEAKEKNWREFVGNKSRDDVWKVISVCMGKRKNESLIALKVGDGWTKDWSESVNVLLNEFQQCIPDDGIPVEAGGSNERVVDEFDENEFRMNEFMSAVRLMSVKKALVFATAYRRSGLVYRNLYGFVEDQTPVREALQRLAAGARNFLQEGENFLSSQLKDSTPRYNQEYDFVVIGAGTAGATVAGRLSEMEDQTILLIEAGPNENLLMDIPLIVNYLQFSNDLNWKYQTEASKTYCQGMTNRKCNWPRGKVMGGSSVLNYMIATRGNPLDYDAWAEMGNEGWSYDELLPYFKKLEDIGIDELKYDRELHNVDGPVHITYPPYHTPLAESFLEAGLEMGYPIIDYNANQDIGFSYIQATLKNGTRMSTNRAYLYPANRRKNLFVTRLSHVNKILIDPVTKRAYGVDYTKLGMNLRVRARKEIILCAGSIGSAQILMLSGVGPADHLNEMKINIIQDAPVGENLMDHIAYGGLVFLVDQPVSITSTVTDPTKPYLRDFLNTRLGPYTIPGGCEALAFLDVDNSESLHGFPNMELLFIAASLVSDTSFHNNVGISREYWTKMFARVAGHHSWTIFPMLMRPNSRGRILLRNKDPHSKPKIFANYLDDPEDVRIMIKGIRAAIEVSRTKSMRRFNSQFYDFTVPGCEDYEYDSDEYWECALRTFTFTIYHHSGTCKMAPENDPTGVVNPRLQVKGIQGLRVADASIMPMIMTGHTNVPVIMIGEKLADMVKEDWGYNTEILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F528</accession>
    <name>A0A232F528_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000922">
        <property type="protein sequence ID" value="OXU25891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F528"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="398" mass="45060" checksum="66C4CCD8B905C2A3" modified="2017-10-25" version="1">MRSSDPVQRFVIHVVETIPYASFLTVIAFHLIKKLVREVFVLIAFGINKLFPRALQAKNETLVRWLIKAGVNVRACSYHNTALYLLLEGEEEKKKSSGKNLCFRRFFSRRGAVSTKEIDLQRRVRIAKLLIQHGADVSASFYLDQTPFGWATLQSSRNRALIQLFLDNGADVNRKNLHGRNVAEEYLANAANTVYLPNTRGGIEPAFLKLIQPSGTYTSALHEACIFHRTLEIRNDTILLADGDINAKDTFGHTPLCYAVLSTSTADAAEDKKSTINLLLRLGADINQKIILNFFNEMETSILELAVLLGDRDIVEILLQHAAKLVDLESGDEKKALSDFNLEFIHNLDFDLKQSYLEYVEELREIRMSMQLAEEQTSLSRSIWFKKAFEGLSSSVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F553</accession>
    <name>A0A232F553_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine-rich glycoprotein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000985">
        <property type="protein sequence ID" value="OXU25609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F553"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031959">
        <property type="entry name" value="DUF4779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16009">
        <property type="entry name" value="DUF4779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012353279" description="Histidine-rich glycoprotein-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="31165" checksum="CEA8731A910888D0" modified="2017-10-25" version="1">MINRNDRAMLLLLLISAVLLQCGTGRKIYSRPLRFRYVQEDQETSDTKHEDKHHHEPEKHEVAEESEHHRGEHHEDKDHEGHKGYKSYHELDKAGKEHLDKGGHSHHYEEEKNHGGEKHEEAGHYKDHHKGEKAEKSAEFEEEAKHQKGHSTKGEHNIFKKDEYEKKHDFYDEFHEGDDHEKHGGHNEHHDHHKGGHKKDGHEHAGKHEEKKGHHKEHRHGHHQHKHKGHEEKGEHSQHRDHHEKYGEDDGHGMGKHWAHKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F592</accession>
    <name>A0A232F592_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase Era, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ERA-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_016009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000980">
        <property type="protein sequence ID" value="OXU25633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F592"/>
    <dbReference type="STRING" id="543379.A0A232F592"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002220">
        <property type="entry name" value="GTPase Era, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Era-type G" evidence="7">
        <location>
            <begin position="49"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="6">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="6">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="6">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="6">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="6">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="346" mass="38593" checksum="779BE5EBDCE1EBE1" modified="2017-10-25" version="1">MWICISKKAARAGAQIVRQVSNFADDLGESLIEAKKVFLNDHDNKKNVKSLKIAILGLPNAGKSTLINHLIGRPVCATSSKIHTTRKKASAIFCLDDTQLVFIDTPGLVGRGDVKKYKLEDSFKKDVQHSMKEADVIGVLQDMTNLHARKFIDKKIMSILELSAAETNSILILNKIDTLKHKKLLLEVVKNLTSQEAGPKFSDVFMISALTGDGVDDLRNYFLDSAKERAWDYNKKTYSDQTPDTIVKEIVKAKFLDDLPQEVPYLVDVVAEHVEKCEDGSMNVVVNVNCPSVRIARMIIGKSGERVKKVAKEAEQLLCTTFTTAVRLKIAIPIKEEPLALKKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5Q6</accession>
    <name>A0A232F5Q6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="6">1.3.8.1</ecNumber>
            <ecNumber evidence="5">1.3.8.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Butyryl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSAR_009309</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Alberta</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:12276"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57345"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21 22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="6"/>
    <dbReference type="EC" id="1.3.8.4" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000902">
        <property type="protein sequence ID" value="OXU26005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5Q6"/>
    <dbReference type="STRING" id="543379.A0A232F5Q6"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 22" id="KW-0274">FAD</keyword>
    <keyword evidence="8 22" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="25">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="24">
        <location>
            <begin position="161"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="23">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="377"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="406"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OXU26005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="423" mass="46437" checksum="0D70B5E5F6E989C3" modified="2017-10-25" version="1">MSSHTLRRGLQPIFARSSPLLQYCSKALSSQYYAIDENVFGLSEQQKELRNLVFNFAQKELAPKAAEIDKKNHFDELRPFWRELGKLGLLGITVKEEYGGTGGGYLDHVVIQEELSRASAAISLSYGAHSNLCVNQIHRNGTEEQKHKYLPKLCSGEHIGALAMSEPGAGSDVVSMKLKAEKKADYYVLNGNKFWITNGPDADTLVVYARTDPNAAKKQHGITTFIVEKGMEGFGTAQKLDKLGMRGSNTCELIFENCKVPAANVLGQENKGVYVLLSGLDLERLVLSGGPLGLMQAACDVSFEYAHTRKQFGKNIAEFQLIQGKMADMYTRLCSSRSYLYSVARACDNGHVNGKDCAAVILYCAENATKTALDAIQILGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMVIARAISAEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5V2</accession>
    <name>A0A232F5V2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_007016</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000937">
        <property type="protein sequence ID" value="OXU25828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5V2"/>
    <dbReference type="STRING" id="543379.A0A232F5V2"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000041">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="160"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="18">
        <location>
            <begin position="345"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU25828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="438" mass="50776" checksum="D632E91E7AE5AF8D" modified="2017-10-25" version="1">MGIRVYRILLAAEKYKRKIICRTYSTAPEANKSLGSIELLGQKYPTDDWTNITPKIISKLGKNLHVTKNHPLSHVRQCIVNHFYRTYSNRVGNPLFSVYDNLRPIVTTAQNFDSLLVPPDHPSRKKSDCYFVNQETLLRAHTTAHQAELIAMGLNNFLVIGDVYRRDEIDSTHYPVFHQVDGVRLCTTEEVFQYVKDSNKLSIFEHRGVESADKQACHSLESVKIMEHDLKQALVGLAQSLFGKDIKYRWVDQYFPFTHPSWELEVFFNNNWLEVLGCGIIRQEILQKTGTVDRIGWAFGLGLERLAMCLYSIPDIRLFWSTDPGFLNQFITDDVNKAITYKPVSIYPQCYNDISFWIPQDTPYCSNDFYDLVREIGGDMVEQIMLIDEFVHPKTKKASHCYKIIYRHMEKVLTQEEVNQIHKQIEKAAAEQLNVVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6W9</accession>
    <name>A0A232F6W9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000860">
        <property type="protein sequence ID" value="OXU26179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6W9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="13464" checksum="74C28C3CF8E158C0" modified="2017-10-25" version="1" fragment="single">MVRSQQLYSRHPQESQKKQRRQKKTKRLSSALSIISQVTVDYIDFHIAPMFLYTVYACATLYINSQNNYTDFDIAPMFVHAVYAWSTLYINSVNIDSVTLKDWRTEKKVFMLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F775</accession>
    <name>A0A232F775_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000829">
        <property type="protein sequence ID" value="OXU26293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F775"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12044" checksum="5470D4A9B9F2C05D" modified="2017-10-25" version="1">MEFKIPDERSTEAARDVNKRTEGQADLSLAEFVEKDQVSHSQATMEEQEEKSPTVATQTESTAVCHQGTSVNEFLLATGDAILTTELRIRVKCHTAFCTSGQVATFQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7A8</accession>
    <name>A0A232F7A8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_000388</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000743">
        <property type="protein sequence ID" value="OXU26731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7A8"/>
    <dbReference type="STRING" id="543379.A0A232F7A8"/>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="454" mass="52135" checksum="C00A61584D8EFD70" modified="2017-10-25" version="1">MTRKCIMCKSKNYKNTYSFFSAPKDPEIRRLWQEAINIKDYTVNEDTYVCSKHFRKDDIITHWVSGVPPHVITIKYKKCRLRPGAVPVPLDSTNNSVNDTTSETQKNGIILDGKKYFIEPKKKDLDSSSKVHKSEEASNESLNCNLEDEIYEYIPEDSQEPEEMEIETNPTRKRQKLHDRNTSNQEIILVDCTNDDADIQVNDIEVEKNKSNKPLDDLDNTETIVTYLPKRTYIKVKKGLKKADSNILSEDMVSSMNWHDATITEKFAILKDNMDDINENLNKSDYEPVHLAQEIIYCDNTLSFEDFIEMYNEVSLPSSWFTSLVSKDHDTTVIYCCMNISSSGMPYLEKKIFLSNNMILRCGVFNKEINIANISKTGRNRVVTALADIEEFIKDFDQMSICPGILGENFAENSNQAVVTLDGSTWRHSQCSMILSENQTTCLQCASLMRRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7F2</accession>
    <name>A0A232F7F2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000730">
        <property type="protein sequence ID" value="OXU26771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7F2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10269" checksum="3FB3F374FA17428C" modified="2017-10-25" version="1" fragment="single">MTLLKSPNDQVLSCARANASRYSPSGLAVTDWPFSLSTLKVTLKIRGRGSCQSKNDYKITPNPIGLKPRIALSIRDYESQMMEKRSLNLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7W5</accession>
    <name>A0A232F7W5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000751">
        <property type="protein sequence ID" value="OXU26692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7W5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="23986" checksum="6B7E9EA635F78F15" modified="2017-10-25" version="1">MTPVGHRCLVIERLVDRKGRRKYVKDNIDFKEKRGRKELWKWRWVAGEENFYILDEWLSIKERENRFHLVKTARELEEKNIEKGKKIKVKLENNWIKIGEERYKWNRKEEDLKKISEKEADEESVIESWKEAMLCEIRIREERTKQEKEKEEKKKQELEREEKEMKESVQKKLESTQKERKEESSKEKEESECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F815</accession>
    <name>A0A232F815_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000685">
        <property type="protein sequence ID" value="OXU26984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F815"/>
    <dbReference type="STRING" id="543379.A0A232F815"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="351"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="629" mass="70239" checksum="BD4DE8D81B2B70EC" modified="2017-10-25" version="1" fragment="single">LIKSNAIICPNRPVRPQGCSREPPVDLRYDESKRIDVRRKSIIDNNSRERQRVLGTDAAIPMMNEFADQQRPFNRNGKALRASKKSALYYTTDCGGDENDNIEHNLQQRSVSLTALHTSSGSPQQQQLTEPRMAHLETLEAKMASIEVSLSSTPRRKKGGSVSGGMTSPAAHRNRDYYKELDSLRVALRDKENIIQTLKGQLCNTLSNRLALRNGAPPLTEADRKATEERLQRLRRDADNKRLAIKNLKLALERLDITDNIDVRIQQAELEYRLGREELELLSLREESRALQAAIELAETQEKQKNDTIFSCITGSTQITIHAVEVSADPKSPRFGAGPREDAAGLYVDWAIEDSGLCKGDRILEVNGKLVVGAGRSDLARLLAVAPDAAQIVVLRKNESLAALRTLRSDNLRLTHRISYLEEQVRDLLAPRTEMPVESSTTAVIESPPARKDHLQVFQKGPQVTALISSMGPGLILKGSPDTRQSLPNDNQSRASEHSEASTTAYSSQEYSSSSNKSRPAPPKKPLRLSLHRAASLQSVESAPPTTSSSNHHHHQYHYHHHQDVYTPSKKPTKRNYRGDLPINESQQQEAPQPPPRTPSRAESCQSALRWPSPKPRPHLTQLSMEKWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F938</accession>
    <name>A0A232F938_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pericentriolar material 1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000686">
        <property type="protein sequence ID" value="OXU26978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F938"/>
    <dbReference type="STRING" id="543379.A0A232F938"/>
    <dbReference type="OrthoDB" id="2125770at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1133" mass="126995" checksum="E796C514C024AE2B" modified="2017-10-25" version="1">MSTAILIQSFKLALDIPTLLQLKKQETILTYWQIAATMSPGVNDHLRSTGAFPKSNRRSDRNRERDRAANQNSNFRRAPRAQAQHANNLLDWHPACELIQTSSRSTPVTSARTAKNSNARSSAPIASYDLPDIGLYNAYSRLYPNIHALEDLTPWLKMTSPVDQRTQSPPNLTAKPTNTDKMPERGQVEGRLNQIREYIKVTSTMMDSLSQSSDPRAQAQHDKLSKMVEDLYDSEVKLSKLMEDCQKYWRPAENVELENGEDVREQELRKKVEESQHKLAQLQEHQAQLVGMQLRVRERLNEARQAQQALLVDDEEEEEGEEHIQGAEEQPNQGNVDQLERETEVLRGKLQQLENKKRHMDHLMQELQAVEHIERASCSSESSRTTGQRDKVAELEAMKAQLSYLKALMNNTTGEREPVDGIQNSEPELVEDEPPIINGGVDDVYQLEENHSNEYNDLDETVKPKRSELPSVERIQAVTRELKEQQLMLQAARDELRRLKQGNGNPQAPPSLTSSTPPLSQTTLVEKKQSNHTASNNGTVRQQAQNKCWQLEDMMRKDQITGLSVNQNGGPEWGSRRNSTSQHSHTSTTPGNLWPPPVNHGSINTAPHHRSVDGISTAENLLELGSQPPMENGFPGNFWNMPAMLANQPPQAGAVAGSAEYYRQLLLGSQAQQLQLMSTTVQQCCQLLWSQQREMQSMRAAINQLQAQLRQSHSRTSNNNTEEQHSNLGRPAQPHFDVTPLPPSSSLPNLVSLPTSSPAPPPVNCHHPQPQLQQPQQQQQQPQLNNQVPPGNRANNYWDNFRSYSRQNLLSGSSKTVTDHTTVASSTSSSNTASGSHASNKCNRQQGLDSHLPPGDAQYSLNLQQIPQEERNNYVPMNEASSSQQQQQPEHSRADETVTSYRRQPRLRDEDSCARIAKKIAGRDDLRHILMQCLNVLESRKLDESPLPSSNASNTTDSSDDESEAGARSSTTLPSAIGNFNSDNQVSTSELIDTASLAPIMHYPTHQQVTEQNETSDTYSLGDTIEKYYHPMSSLSMTVSSNTQVHNDATEPDIITQEASNNNQQTNCDSPYVDPVDSTNPDEGAAAISILTLDELKAEEERDRAEYVMLERTPTSQQPHRSRCSPRMDHLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9M1</accession>
    <name>A0A232F9M1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium channel protein Nach</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_013004</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000660">
        <property type="protein sequence ID" value="OXU27138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9M1"/>
    <dbReference type="STRING" id="543379.A0A232F9M1"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF237">
        <property type="entry name" value="PICKPOCKET 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU27138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="73009" checksum="ED39D9D6AA806130" modified="2017-10-25" version="1">MNEGARVWKSYANDEWASIYIFVVMSVLERKGEKFWKPVIQQYCENTTLHGFRYVVSRDSTIVEKFIWLLVQTWKNLILSIISNKRINEFLCNNQVCILGLSFSVALMMLVWQRFKQTPTVTTIESTTHPIFSLNFPAVSICNYNKVYKPHADKFSEDMRRKGLSEQEIVTFFASLPKLVRPDYIDADNRRALELMTSPEVTIEDIMYDMMQPCEKLLLRCTWEGKVYDCNKIFKPIKSIEGFCCAFNYHVDTSENSIFGVKGAKKYINVSSAVRHNLTKEEPGVFEVLSVPGAGRDVGLSVVLDLEKEAYYGSIKPSVGASILVHDPFNYPEVEILTSFIQPTQEIAVILSGTIMESAPDVRNLDLTRRNCWFNDEKKLQISTVYSYQSCITECRIRYIRRYCNCVPFYYPNYYQERVCTLLDVDCLTKYRGSLSNLRTIIDLVTENNTQDSVKCECLPSCDDNRYTSNSENAFMENVSFHLPILEGFDVKNVSLASIYFRGITCLKYRKESWMSWDDVLASFGGIFGLCVGGSFVSLVEFFYFFANKIFRNSKEQHQQNFVSTPPAREKFKVVSIDRLSDWSRKTKLEVESSQMKELTALKQSYSYSVQSAGVKPDLQEDFIKHFLKQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9R0</accession>
    <name>A0A232F9R0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_005444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000651">
        <property type="protein sequence ID" value="OXU27179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9R0"/>
    <dbReference type="STRING" id="543379.A0A232F9R0"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU27179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="63018" checksum="BA43B256D5EC6445" modified="2017-10-25" version="1">MLDPSFLVNLVTVLATLLTTFYLWARYKQSYWSRRGIPTAPNSHWFFGHFRDAIFMRSAPPTLLGELHKSCPSDEPILGVYIMQKPFLLLRNAELIKQLLVKDSQYFPNRYFASKRKSDVIGSQNLFSVDNPMWKYLRVKLSPAFTTGKQKRLFELMLESSQNMRKYLEANLPKDGTEIDMEMRRVSSKYTTDVISSLAFGIKTDSFADPEAEFYLRSRKLFEQSIINTLKLFYNFFFPKLNDIVGSSFLGAEEDYFRKIFWESMNQREKSGVSRGDAMDLLLELKNEKQSKEFRFEGDRLVAQSVILFAAGLETSATTMSFTLLEIAKQPEIQRKVREEIRDKLNGKPLTYERISEMNYLHQVVSETLRLYPPAPLLDRVAIDDYKIPGTDIVLEKGTVVYVALNGVHRDPDYHSAPLTYDPDRFSEMRKKDMKPCTYMPFGDGPRICIGMRTGMLQTMVGLITLLSQYEVKLNPMYKNEISKRAIFLAPANGIHLYIKSSPIIVKLERIPGIDITDEKETVIYHKGPDYNADPMTYDPDRLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA43</accession>
    <name>A0A232FA43_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000586">
        <property type="protein sequence ID" value="OXU27535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA43"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8557" checksum="104EA64AA35A5882" modified="2017-10-25" version="1">MASKSEKQSSKTNIIKSSYSTPRDSLYKRPHIVEKQIRRKQEREKNRNRTNIDAPKQKLLNLANLRCEIPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAG1</accession>
    <name>A0A232FAG1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000604">
        <property type="protein sequence ID" value="OXU27428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAG1"/>
    <dbReference type="STRING" id="543379.A0A232FAG1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF227">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="615" mass="68813" checksum="09035A2C60CEB18A" modified="2017-10-25" version="1">MTWIPAGATGHCYQNLFMSTCEPSFLTFLTFLTHYLGPSKDDRFKKTENKNELKEFDFIVVGAGSAGCVVANRLSEIKNWKVLLLEAGDEQPLIVDVPGFAGLLGNSSIDYGYTFQTDNEVCRDNPNSCLEPRGKVMGGTSSINGMVYVRGNKEDYNDWAKLGNHGWSWDEVLPYFKKSEDLQDKIPHGNPKHHSTGGYLGISLPEKDSNIDVIIDSWKELGYDEIDYNSGSQVGVNKFQYTIKNGVRQTTNAAFIRPIRGKRANLFVRPNSHVTKIIINPKTKVAIGVEYVEAGTKITKRAFAKKEVIVSGGAIDSPKLLMLSGIGPVDELKQAGIKQILELPVGRNLQEHVAASPVTVSLKNSPAPFKPFDEKVQDVKQWLANRTGPLRRSGAWGVIPFIQTSYETRPGVPDMEIHYLTSFDAEELNGSTALYNLWSYYNKLTVYTTLLTPKSRGWIELNKTDPIWGKPLIYPNFYEHPDDIKALVEGLSLTKKFTETEAFKQSELSATRTPAPKCEKDLGDEDKYHECIARNYFLPLYHPSCSCRMGPKSDGNAVVDPRLRVHGIKRLRVIDASVMPVVIKGNTNAPTIMIAEKGSDLVKEDWLVPRRHERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAH6</accession>
    <name>A0A232FAH6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000600">
        <property type="protein sequence ID" value="OXU27459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAH6"/>
    <dbReference type="STRING" id="543379.A0A232FAH6"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="425" mass="48101" checksum="E9953B466E1AAF93" modified="2017-10-25" version="1">MGKKPTTRPILPLLISNWVLGIGIIEYPIGTPRPTFSFIYSTTLLVIYCTTSIMIRDEIFRVSIILKNYTVPMTIVFYTNIFLTISIVTLGWYRSKGLRRYVAKAAVADDLMERIGIPNNHGKMLRAVAGQVIKGFFLVIVLIAIISVIVLVEDSPLQTKILISTVMSFPLLTMFVSDAMFTSCVRCACYRFTELNKVLKTVLTSTHAFPQHKRVCSSVFESGGQDSNFVIDNVSQRKNPAVIVKLAKEIHLQLISACQEINNTYGLHLVLSIMFAFAVITGNMYLCYMSSRNSNIPHYVLVKTMVVSGIWIVYYGMKICYFSIVCGCCTENSIKTGDYINELYDEPSTTNETKLKIRQFNMQLIQKPCKFTAWGFVDLNCHLIQVMIGTITTYLMILIQLGTTTYVADDSYYKYLKLFNNSPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAN0</accession>
    <name>A0A232FAN0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000596">
        <property type="protein sequence ID" value="OXU27493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAN0"/>
    <dbReference type="STRING" id="543379.A0A232FAN0"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="270" mass="30206" checksum="5D17E71AFFD6B029" modified="2017-10-25" version="1">MLHLDEKQLKAMHTRTNLRRLLDYVANSQVEKIAKMCGKGLDPNFHCQDTGETPLTLATTLKKPSKVIIALVNGGALLDYRTKEGLTAMHRAVERNNLEAVKTLLELGASPNYKDTKGLTPLYYSVIYKTDPMLCETLLHDHATIGAQDLQGWQEVHQACRNNLVQHLDHLLFYGADMNARNASGNTPLHVCAVNNTDSSCIRQLLFRGAQKDALNYANQTPYQVAVIAGNMELADVIKNYQPDEVGEFPRESREIISPPLFRSLTRVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCC1</accession>
    <name>A0A232FCC1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000456">
        <property type="protein sequence ID" value="OXU28272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCC1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="58" mass="6667" checksum="6FAAEBF6C543D74D" modified="2017-10-25" version="1">MQCKKARLAFHRRIRKHVSTPRRNMESVRGSSRDNSGTRGLIGTTAKRMRNLSLSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCP3</accession>
    <name>A0A232FCP3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000460">
        <property type="protein sequence ID" value="OXU28228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCP3"/>
    <dbReference type="STRING" id="543379.A0A232FCP3"/>
    <dbReference type="OrthoDB" id="7613031at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="12060" checksum="9FCDFC98B8ECE30C" modified="2017-10-25" version="1">MEEFKKINWHPSIEDMIDNTFLNEKRLQTEGAMYQIMNGVFEDPFQELRPRVPISFKADASKKTKTNINNDDNNKKKVVPRKRTKKKKKNNKKPQNKPTTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD05</accession>
    <name>A0A232FD05_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_009638</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000460">
        <property type="protein sequence ID" value="OXU28227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD05"/>
    <dbReference type="STRING" id="543379.A0A232FD05"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000475">
        <property type="entry name" value="zinc finger protein 32 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU28227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="395" mass="44480" checksum="98D8DDB84D4510BA" modified="2017-10-25" version="1">MFSSVQIKQEYNGADDRGHENMVGGQGNNVDYSVFDNQNVQYAYHQLPHFWDQALQVQTNQYPKDFSQKNDGITRQDMSRIPPGIPSISTNYLNHHLQQQQQQHQQQQHQQQQNSFPLNHQATADHSQINPVNQSNVGSEHIASRVASEIISNSGLMNPGLMAGQTTTSSIKRSNPGRPSKSTNSTDSPGKKLKCQCEICFKEFGHKSNLFIHMRTHNGERPYKCKQCDKCFTHSGNLAIHMRTHSGERPYACQVCGKMFSHSGNLSTHLRTHSGVKPYKCSVCAKEFRHSGNLSIHERIHSGIKPFQCKVCGKEFYHSGNLTTHMKKHPVTVSTEQCKNNVLPALSTDYISNNVHQVKETESILISNSSDLNSTIQNSNEIVIEDKLHEQSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD80</accession>
    <name>A0A232FD80_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000388">
        <property type="protein sequence ID" value="OXU28746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD80"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="57" mass="6366" checksum="E5A3C4D97D0C5C58" modified="2017-10-25" version="1" fragment="single">SHDYSEGHLNAHFSGHRGKSNLLCPLKSAIERSCTNSQMFELPVAARCFNKTMSIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDA0</accession>
    <name>A0A232FDA0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore complex protein Nup98-Nup96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_008304</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000442">
        <property type="protein sequence ID" value="OXU28347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDA0"/>
    <dbReference type="STRING" id="543379.A0A232FDA0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF441">
        <property type="entry name" value="KELCH-LIKE PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21240">
        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="383" mass="44953" checksum="6B7D50E9F3161EF2" modified="2017-10-25" version="1">MSFFEKSFEMNTVEMNYIYKRPDHSAWLQTIRERDELCDVTIKVRNKQIRAHKLVLAATIDYFHRMFLGNSEERMKDVISIDDFDEEIMEAIVTFSYTGKIVFTKENAADMLKATHFFELTDVKYKCIKFLKYNLETKNVFAMLHLAKLVPGCTSLLERTEKFIRRNLREVSLTDSYRNVDIELLKSILSREVPPIYNSEIIFEAIMRWISTDVDSKMTHLSELLRHVSLLDLSSQFLIGFLFKDEFKNSIGPKHREIVAEVLSVFNELKQINDSKNTTAVIRIVSRSIATKRQKNKLKIFFRLFIVGTSLVKFSSIVLLNTDIQIRNKTAYRISTRLHSITAMREYKSKSFEELRFEDYNAGRNKGCKDVARCPYFDLNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDX1</accession>
    <name>A0A232FDX1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_008982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000419">
        <property type="protein sequence ID" value="OXU28537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDX1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="93343" checksum="618C2147B0C8ECB5" modified="2017-10-25" version="1">MDLYESPYCTMVKRVLKVCGLWPYQSNFKRRSNYVIFIISTFSLVFAMATGIYTQANAKLLIIIETYCALCYCGGSFFAYTLLYIRRVEIKNWYGGVVDGWIRLADASERKIMDNFLLEARHAILCEVIVYNTLGNMPIKSMSLKFSGYGFPAFGIFVCFTFLPRIFRKESLEQSLQNFPCYFKSIIINENTCDLQISVHFTVTILFATSAYFSVSAIYLTSVKHVCGLYGIARYRLQHSVVYNKNLDSLRKLKDYSSVIPSLINVIDIHKDALRALQMIEKNFSLGFFFLEICALALLAVLMFEANYNRGNVNVLIRCLPLLFNFIMYVFFMNWCGEQVIQSCDDLRMSAYNIDWYGISSSRVRIFILMIMQKTAKPAHLTAGTVMLLSIQNFATDCVVIWDVAINYAKASQYFKSNKRLLEVCGLWPYQSTLRSISNYAIFTVTLVSMVIAMVAGIYSETKLLHILEGSLPIIFCSGALVAYMLLYSEKKEIKERTELMATDWMELADDSERKILGTSFLEARSAINITIGYGIPVYGLFFGVTFMPRIFNKKSLEQCLRSFPYYFKLIVIDESTCDLQVGVHFALAVLFSSFTFLTIGSTYIISVKHICGLYGIAWYHRLRNAELVLDNESLDALKKSSEDYDTRVIHSLIKVIDVHKEALRGIQIIEKHYSFGFFLLEIGALVVLAILMFEINYHKEHISELLRFLPLLLLFTTYVFFMNWCGEQVIQSCDDLRISVYNMDWYKKSSRIRIFVLMIMQRTTKPVHLTAGTVMLLSIKNFATILKTASSFGMLLLTTQKPGKNKDANYLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE88</accession>
    <name>A0A232FE88_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000386">
        <property type="protein sequence ID" value="OXU28749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE88"/>
    <dbReference type="STRING" id="543379.A0A232FE88"/>
    <dbReference type="OrthoDB" id="6817055at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011303137" description="Kazal-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="115" mass="12254" checksum="BE55B870E457254A" modified="2017-10-25" version="1">MKLAFALGAVLLVCLVCSIEAGPTEKPVTTAKPTASKEVKDAIKNAKEAKKAKKDCLKSCPTDYVPICAHDPANASFKPRTFGNQCVLDTHNCEMGTKLVMKMKGECPGSDGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEC1</accession>
    <name>A0A232FEC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_004900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000336">
        <property type="protein sequence ID" value="OXU29116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEC1"/>
    <dbReference type="STRING" id="543379.A0A232FEC1"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="363" mass="41246" checksum="62D03F6E2E3808DB" modified="2017-10-25" version="1">MSNSEKPTGSMLEDEENSVTMLDVLQEENALEEDAIAVLGASDDQNCTYSKGYIRQALYACKTCCSSGTRAAICFACSLHCHEGHELVELYTKRHVRCDCGNSKFGDKACSLDTSKTSENSENKYNQNYDGVYCTCARPYPDPDETESDEMIQCVVCEDWYHSKHLGDSDNLPGDNDYSEMICAGCMKAHEFLWRYATMYSVSKVKKPPANTEEKVDVEESKEQKKECTLPEADFPKKEGSCFWIEGWRSSLCTCDKCKKIYEENSVSYLLDPLDSVQAYEEAGKANKNETQYEKGMKALASLGHVEQLNAIVEYNNMKDSLKQYLQKFVENKKVVREEDIKEFFTGMKSQKRQKVIVPSFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEU0</accession>
    <name>A0A232FEU0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000329">
        <property type="protein sequence ID" value="OXU29182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEU0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="534" mass="56909" checksum="5C92286A673DC58A" modified="2017-10-25" version="1">MVDLSEGTGDMGGLKPRDMLLWELLTAESLSESSRDEVEAVVAAGRAADALETLGRVGGWTDQLVAGGVRGFGAVDQGGRSLATIVVVVVVVVVGLAVAAVDREALALEGRGVVGEDLGRGHFEGAASSDGRAHGAGVARQGALGAPLVLDVGSRSLIKIYSVDFDIKRATMANSYLVVQNGIPRLDLRQVDDGLIDGQGVLLRDDQSSELGYSLPPLLDQLVQAALPDLVAGSLEGRHQRVGPRDDGHRAIAILVVVGQQFAGRLESVVPVGCSRRAREARGPGQSVGLSLARRCRQRAVEALVRAVGVVGGVRAQRTAALGRAVAARQRRLLVQVAVVGVARRTRGRRGLRQAGRFLMHRSAQVEGALGAFAHRRALVLGEHVVGGLVLGQPLHRRGHRRRGEERSLQATLRREHCDLVLDGGLRAVVLTPEVAVRARELPVLLTVELGWSGGADEASFKSKEKRARLFTARGKFRFDSLYELLLFACKYSCRPCGFRSSRASPVASDTHLKQNKIMAGVRMSLVRALNAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEZ9</accession>
    <name>A0A232FEZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_004995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000318">
        <property type="protein sequence ID" value="OXU29265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEZ9"/>
    <dbReference type="STRING" id="543379.A0A232FEZ9"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF203">
        <property type="entry name" value="FI18611P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52945" checksum="86BDC8BAB2106090" modified="2017-10-25" version="1" fragment="single">SRVVLRVASRRSAVAFSRSFSAATISARKNAARANSYEASRRSFFFLFPPPTRRTSSSSRRSRRTDSLSGIHLRERIIHKRAFLPRLLQTFQDPRCLRRIHNDEMHINDKNPEHLMHIIATKAMEAMNDTGAGHDEHDHAAAKEEAVGSVLTAKTVTMVTLCLVSICMGIIPMQIAKCFNIVSTNQVVNPRSFKYVSVLLGFGGGVLFSTTFLHMLPEVEEGVEHLMEEGVFPHLDFSLAKVFCCTGFFIMYLIEEIVHAHLKHRHPKRASTDAASKTSSNVNIYSTESIDSYGSVAATPKWKGHGGHRHEETCEIGHTHLDIIEDCDSFHDGAIRGLLIVLGLSVHELFEGLAIGLESSAQYVWYMFGAVAAHKFIIAFCIGVELTTSRTRAILSYVYVCMFAVVSPLGIGIGMILVGGNSAAASGPAAVALQGLASGTLLYVVFFEILHKHRDGLFQYLSIILGFLVMFGLQVLSEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFT8</accession>
    <name>A0A232FFT8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromodomain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000291">
        <property type="protein sequence ID" value="OXU29423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFT8"/>
    <dbReference type="STRING" id="543379.A0A232FFT8"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="552"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="7">
        <location>
            <begin position="837"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="789"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="913"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="971"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1191"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="134237" checksum="B2EA5A6CDB602DCC" modified="2017-10-25" version="1" fragment="single">MLCSGTETKMQQVDSILQNNSVILRIFHNAQVCPNKIEENKSWSEEKAHTKVIGNISNFKYYILAVYFVHSFISLSTSWCTFLTLILDMKLTPRYSFKSIDALKPCILRVFKTKANPARHSSLNYVWTSAPGKASTTPAVPAKEPPPREEPPVEPVNGIVQPPVVPPPNRPGRVTNQLQFLQKGVLKPLWKHQFAWPFQQPVDAKKLNLPDYHKIIKHPMDLGTIKKRLENTYYWSGKECVQDLNTMFTNCYVYNKPGEDVVVMAQTLERLFLTKVAQMPKEEVELEPPVAKGPKGKKPGGVGRVAGVPLGPGVPPGVPGTPGRGRPSSGAPTVSSSVPNSMIVPTATTTGTTGPIPAMPPMGTQVPASVPGSTNTTTIAPPTAPTLPGVTSMATHNSLPPQVVPPATGYHAQAAMDPQTAAAVSAPPQVPTAATVMPPSQPAKLKKGVKRKADTTTPTANSFDPIYAPLDSKNAKIPTRRESGRQIKKGLMGLFQPTRQAEDGLVPFHQANMPLMGAMAQQPQHTSSKLKDKLSEALKSCNEILKELFSKKHSSYAWPFYKPVDAELLGLHDYHDIIKKPMDLGTVKVKMDKREYNTASEFAADVRLIFTNCYKYNPPDHDVVAMAKKLQDVFEMRYAKIPDEPMGGLVGLKGSDSSGSSSVSEDSSDSDDSEEERTQKLVALQQELKAMQEQMRKLVEQSGKKKSKKKKPEKPNKPKSLNNKDLMAGGHSGAMKELMKSGIRSVSESVGATLANVSLGPGHHLPPNSAAAAAVAAQAAAAVAAVTGNAKAPKGKSRGPGKATAANAANKRPKTASRSSGNKKKNAVNQPPPIVFDSEDEDNAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPSTLRELENYVASCLRKKPHKKVSGKSKDEQMAEKKQELEKRLQDVTGQLGNIKKPTKKEDSSKSVDVVGTAGTSAPSRLSASSSSSSDSDSSSSSLTSSSSDSSDSEAGTAGNRPPRKKKKLSTTASTAPTTATTTTTTASTVPTASNLNHTGGMLMNSQTTANTTGPATKPAATQPSNNPTDQVTQTPNDTVLSGLSASNANQSTVSQPGAVAAVTASPSVVAPPAPTPPVASHASMPAQPSRPSSLATAVPVKKPPVIPPVQPIQQQQQPIPSSQPITTTAAPATITPTIASIPQQQHQPQQQQQQAPSITSPIVPQTVSAAPPVVTSFPSVATSLAQHDVVSGVVGQQSDLLQPYNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG81</accession>
    <name>A0A232FG81_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000280">
        <property type="protein sequence ID" value="OXU29530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG81"/>
    <dbReference type="STRING" id="543379.A0A232FG81"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000155">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011820402" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="663" mass="74667" checksum="57BEFDE577CDF2A2" modified="2017-10-25" version="1" fragment="single">MTLGVKCASLLVFLTVVAGNYATEPEVRTSLGRIKGSLMNTRLNKTIFAFRGVRYGKSPEGERRFKQAEPVDAWNDVFDASKEGPSCPLPAAPELTSEDCLRLNVYTTKLPDSKNKVKRPVIVFFHPGGFYGFSAQSYVFGPQYYLDQDIVLVTVNYRLATFGFMSTGDARAPGNLGLKDQVVALRWIQKNIASFGGDSNSVTITGYSAGSWSVILHLMSPMSKGLFHRAIASSGAPTTPDPMPTKQPELITKQASFVGCPSDNIDVALECLKTVPHQKISDSMPKFSEWYGDPILIWSPVVEPEIPGVERFITAQPVDLIRTKNFQHIPIITGITKDEFAGAPLIALEQALKGNDSIYRNLTENWEYAAPISFQYERGTERSKHISRELKKFYFNDEPITAENGKNLGLIYADAIIGYPTQRFAKLMSENSRAPVYNYQFVYQGRYSFSVWRDTKKPYGVVHHDDLLYLFYMSFGFPFFNATDPESAVVEKMTTMWANFAKTGEPIPKDNKLFKGVTWPLLQPKTNNYLEIGDSFAVKSNMFPKRYALWDRLFPLPPVASCPKHYNDATEPEVRTSLGRIKGSLMNTRLNKTIFAFRGVRYGKSTEGDRRFKGVTCPLLQPRTNNYLEIGNSFAVKSNMFPDRYALWDRLFPLPLVASFIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHU8</accession>
    <name>A0A232FHU8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000189">
        <property type="protein sequence ID" value="OXU30143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHU8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="208" mass="23950" checksum="C4475E4314627159" modified="2017-10-25" version="1">MQPEHRGYSWKTRLLELPGCQMNLAALSTGENLLGRSRAGWRLRSQVEEHKKEGNQKKNMLKAPKPSTPETLTPKLVEQGDTFSGLKSIITDVNEYAKSKTNVHGPIKIGLTKALKELEKIEKQGKEEHITKLKKEVDDQVRDCQSTLKSIEDIAKHAQKLKVLVTQLKEMHKMGDNKNNSYERGIKYYEYYNEVREKARRRVQGHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIK3</accession>
    <name>A0A232FIK3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000153">
        <property type="protein sequence ID" value="OXU30515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIK3"/>
    <dbReference type="STRING" id="543379.A0A232FIK3"/>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="286" mass="33249" checksum="1C4EE979CC55FF9A" modified="2017-10-25" version="1">MLSQKILNVIKFSKNQVYQAWNTQFLTTSARVLNRNEWSEEKPNLYDEETSGSVIEKRESDRKSNLVKEDDNIIYAILKSNLELTPWGMKKYFTKKKIEIEKQRQGFSQERIDFLGADLAVAHFLVFQGGKVKFRGSDKWVELNEDKKTADLPSLFNPNYILTAFDASGIEIYYEGLETLNNVPKVTHINFSRSPHFDDWFMDKLSSMYPNLEYLDVSDCPKLSERGLEALYKNSKLKTLIVTNHYKSAAFELTCMMLQDILPELKINIITPKEKMKPIINTYLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIS0</accession>
    <name>A0A232FIS0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000136">
        <property type="protein sequence ID" value="OXU30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIS0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="196" mass="22922" checksum="D6A77EF5C1B2E018" modified="2017-10-25" version="1">MATTAVLALRNRRKSDQQSANTFRDLRPQRAVKMKKEWRDELEQFCWDTGESFFSYAVTFYAMIYSHDRAAAVAEGSKRPEEYTRRTCCKRDTPDIKRRRREKRIRPGNVLLLQSRMRGSRGMGLVPPLLMLMTLLIRQEARLFIKLPRLCFCLFAKADTQSFSSHFPVNQFSGNVDPFVNSILQLSTYPRNTEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ81</accession>
    <name>A0A232FJ81_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000117">
        <property type="protein sequence ID" value="OXU30804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ81"/>
    <dbReference type="STRING" id="543379.A0A232FJ81"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120531">
        <property type="term" value="F:prenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000009">
        <property type="entry name" value="Geranylgeranyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU30804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="607" mass="68095" checksum="31110F2D819DFE1D" modified="2017-10-25" version="1">MQIDMDCQLSDNTPPTVYLNRNWVLKETDPVGYVVERVRAEDNDQGELIYGLEPSTLNYNGNAEPQRPLPFAINSTTGVIYLNETLKGRGGQHMSLYVTVSNGIVPAKAEVYVNIQRAAGSKTGPTRSPFSNQPGNGGLIRPPILRLPSLTIPASSSQSQPQQPPSRTRLKPESASSSPGTSTSLDDRRDDAANDLETPALSSKVEPSEAPPSQDITMTLVPIAAVCALVFGLGMGVWSLRKRICASRKSKEQNKEHTSVSVSTISNDPSLDLKRWRSPKVANNRYEVWDKEAKPGARIKRDDKWEFPRHRLKKLLQPFTYILQVPGKQIRGKLAHAFNYWLKIPVEKLQAVGDITQMLHNSSLLIDDIQDNSILRRGIPVAHSIYGVASTINAANYVLFIALERVISLNHPEATQVYTEQLLELHRGQGMEIYWRDNFICPSEAEYRTMTIRKTGGLFNLAVRLMQLFSDCKEDFTPLAGILGLYFQIRDDYCNLCLQEYTENKSYCEDLSEGKFSFPIVHAIQSNADDGQVLNILRQRTKNVEVKRYCVNLLDKFGSFAYTRQILSDLDKQARQEVERLGGNPYLMAVLDELLAWKKGKNSSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJH8</accession>
    <name>A0A232FJH8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000110">
        <property type="protein sequence ID" value="OXU30891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJH8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="10978" checksum="4D82E80254170CC5" modified="2017-10-25" version="1">MKNSSLRLLDLTSYGSNKIGNLFPAILLPCRRRHQKYFDSQAHATKLKVFNWSSSSIKCAYILALTVSKRKSNELFLPSFSLILLTICQLQWSAAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJU9</accession>
    <name>A0A232FJU9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_001898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ubiquitin-like protein involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000124">
        <property type="protein sequence ID" value="OXU30738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJU9"/>
    <dbReference type="STRING" id="543379.A0A232FJU9"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000150">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="1 4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="142" mass="15562" checksum="2B30ABC58EBBF678" modified="2017-10-25" version="1">MADKEEDGVSEGSAKTGAKTPEATTASNEETPQEPASIDANLTNNEAPPPPVKGKKIEVLLKATGDAPIMMKKKWVVSQDQTIGWISEFIKKCIKLGTEERLFLYINQTFAPAPDQTVKNLYDCYGTDGKLIIHYCKSQAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK42</accession>
    <name>A0A232FK42_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000106">
        <property type="protein sequence ID" value="OXU30910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK42"/>
    <dbReference type="STRING" id="543379.A0A232FK42"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="188" mass="22027" checksum="BF5CC81724FAAEFC" modified="2017-10-25" version="1">MLGHTPATFFSYCTCFIYSKASRQIGFIKRTTSDFKHYGTVAYLYRFLVLPILLYCFPIWSPFTKTSRVKLESVQHRIIRYLAYKNNSLMSRLKHDYTELSLFFNLPTITSLHHYHDCLLSIKVLRDFITSEVIKAKFCVGELAYMLRNHQPLQEESSSSNFGLFSTIRLRRSWNILPRSVTEVSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKC1</accession>
    <name>A0A232FKC1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000087">
        <property type="protein sequence ID" value="OXU31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKC1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601828" evidence="1">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="133" mass="14991" checksum="34EBFFE4EEAC097B" modified="2017-10-25" version="1">MMSKVLFLVLVGCAMVLAKPTVLSEEVPNEVPNKSVEVEVPEKSAEVQVPNKSVEVEVPKESSEVEVPKSNEVEIVEISDEELQEIIKNVEEKINEIFEKVNEGFNDGDFKNAFEEMQKITEKIFGQKKPNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL82</accession>
    <name>A0A232FL82_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_016393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000089">
        <property type="protein sequence ID" value="OXU31097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL82"/>
    <dbReference type="STRING" id="543379.A0A232FL82"/>
    <dbReference type="OrthoDB" id="532682at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU31097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="383" mass="43079" checksum="8E13837D90F8036C" modified="2017-10-25" version="1">METETLPRPEENHTQSDFIQKELNFDVDPDDPLTKASLSDHPVNEWMDILGNGQLRKKVLKAGKENSRPNRSDVCVLKFTGRLEDGTIVEEEEDIKIQLGDMEVIQGLDLAVALMDLEEEAEVETASRFAYGSLGRKATASFPEIRPDAKITYNIVLKSIEFEPDIDELEYSERQKIGNKKRERGNWWFARDECTLAIHCYRRALEYLSPSNDDVMAEKIPEKKVIEPTDAELQALLEDALKVHNNLAAAQLKCEAYDAALKSVENVLRCQPRNVKALFRKGKILHYKGEHAEACATLSQASKIEPDNKAILQELSILKKKTAKDARYEKNLYRKMLGATPDNKQNNVGTASSNKKTPAKLTWSLAGGTLVAVAGWIAYRFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLI3</accession>
    <name>A0A232FLI3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLI3"/>
    <dbReference type="STRING" id="543379.A0A232FLI3"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007476">
        <property type="term" value="P:imaginal disc-derived wing morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF152">
        <property type="entry name" value="UT01108P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="66"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="43783" checksum="4D206C0DF2F90989" modified="2017-10-25" version="1">MSITSRPISSKSSNKRPISSIDARRREQTFKEYETILEGLKQSFDERWKLNVAANSEENGAKFEDFERFRTLGTGAFGRVILVKHKADGGYHAMKILDKAKIVKMKQVEPTHNEKHILWSIRFPFVVYLEYCFKDNSYIYMVLPFINGGEMFSHLRKIGKFDEALARFYAAQVALALEYLHKCSLVYRDLKPENILIDHAGYIRVTDFGFSKMIENRQVLTWTLCGTPEYLAPEIILSKGYGKCVDWWSFGVLVYEMNAGYSPFYSHNPMKTYEKISAGKYRCPAFFNEDLKDLIKNLLQVDLTRRYGNLKGGSMDIKKHKWFQKIDWLKIYNRAVVPSFIPHVSSPGDVSNFEKYEEEELVVGEEELFAKEFENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMH3</accession>
    <name>A0A232FMH3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000035">
        <property type="protein sequence ID" value="OXU31720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMH3"/>
    <dbReference type="STRING" id="543379.A0A232FMH3"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="191" mass="21126" checksum="1BDB294110CB5138" modified="2017-10-25" version="1" fragment="single">MPGKSKVTSKNKIISNQESEKGNISRDLESSSSSEKSSSEHLDLQSSYNSISESPLTPCSSSRFTSHIITSPTTTKPPLRRRNTAGPGMVFSATDPPSYSSSMTFSKISPLASPHLDKRFFDSSLVEMKSQASSTSTLDYDSTEEVWIRRNDFIQDRKKIESASQPLPTIVTEDINNSSLSLQDQDRRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNL1</accession>
    <name>A0A232FNL1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000014">
        <property type="protein sequence ID" value="OXU31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNL1"/>
    <dbReference type="STRING" id="543379.A0A232FNL1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="205" mass="23395" checksum="A23E27F0E2E51E24" modified="2017-10-25" version="1" fragment="single">SYQNPTSFQNYSQDQYIRPQGSALNQQSEFNQPYSTRAHYPPYVSDIERGYSNNNIGQGNSGNQDIYNRYSANQPVGTYSSGSASGIRCTYSTASQGHSNNSQQQTVSSQQTTSLTQSTSGNTYSSSQDYYRQDQIVLETYCFLLEEALRNICFFFKHPIVTNNSANMHLKENKITYFSPFDPRDRPLYSADKMRKENSDYERAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDV8</accession>
    <name>A0A232EDV8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005839">
        <property type="protein sequence ID" value="OXU16535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDV8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7508" checksum="463C15BDACC88106" modified="2017-10-25" version="1">MDWVIHHKGEPPFYHEVSDIREWDKNFLEVDDETLSDIIEAADYLEMGNLLQLCYVHTWRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDX0</accession>
    <name>A0A232EDX0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005929">
        <property type="protein sequence ID" value="OXU16518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDX0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="12071" checksum="F2CEB6AFF3761F5F" modified="2017-10-25" version="1">MANRLHCYICDGRFSARTMSRIDGEENAAKLGIAVQRRDAFNRPPLEVKNLTRLCINCNQSVREEIQAIEEDPSLYYDSNKPTSNQRSSILEFHLNLVYLFYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEG3</accession>
    <name>A0A232EEG3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005346">
        <property type="protein sequence ID" value="OXU16737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEG3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="180" mass="20664" checksum="3C193BBB4782E29E" modified="2017-10-25" version="1">MAQQLKQKILTMNVSEVQKNRSRMSSNQIDMMITYMEDHTYFAKGSITKLGPQEDSSSALAAHNEYVANISESLKSVARNQLDQMRVMCENHRCTNSLLEELNSILKNYLADNPISSAFNQENRRVESVEHDIQPTGLSSSTNSDPINEFDENEEIEEMEILEDEVDFDEIMRHIKKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF48</accession>
    <name>A0A232EF48_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_001136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005106">
        <property type="protein sequence ID" value="OXU16989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF48"/>
    <dbReference type="STRING" id="543379.A0A232EF48"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU16989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="368" mass="42461" checksum="B26317111A9354A6" modified="2017-10-25" version="1">MSEIARRRRPNQLQVREARTSRPVDQRPNKRTSASASEPATPPAQTISPKTSPPIFNSRDSIIKAFEMKNVPRASIEILLASLSKATYKQWWQFCVLSKEDFYKPTRNRLLRFLTYSSQNNASYATLNTYRSAISLLSLEKIGEDLMISRLFKGIEKIKPPRPKYNFTWDVSIVLNYLRSLERSIELKLRTLRSLSFPDLTYKAVMLIILCTAHRAQTLANIKLSNIKSTEKSLEIRIPDTIKTTGRTRYQQLLYLPKYPHDESLCVATVIEYYINVTKDLRSSEKLFISTVKPYKEIGSQTISRWIKQVLCKIGIDVSLFSGHSTRHAATSHAFEIQQYSKYQVFTKFYNRLILPENNSFALAILES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFB9</accession>
    <name>A0A232EFB9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005076">
        <property type="protein sequence ID" value="OXU17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFB9"/>
    <dbReference type="STRING" id="543379.A0A232EFB9"/>
    <dbReference type="OrthoDB" id="7697116at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF41">
        <property type="entry name" value="INTEGRASE_RECOMBINASE PROTEIN MJ0367-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="109"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="425" mass="48339" checksum="2EA78660DD1151B8" modified="2017-10-25" version="1">MTKSCSSDESGDEEEAFQTETLPKKSANRYMLIYDTYKKWQIDHISSLSDSQEKLTSKLKPPTLWSIWSMLKKTLNTRDNVDISYKPKKSLVLKWTDIVIILIFGICRTLRCDELKNLKVQDIEDLGNRNLVSINETKHDKPRQFIIGEHFYDKVKKYTSLRPSDLSSDRFFIQYQKEKCVHQVIGRNKIRETPQAIASYLDLQDANSYTGHCFRRTGATLLSDSDANITILKQLGGWKSTNIAQVLQQCRLSTSKNSLSKIIANKSALSEAVDDDVFDDIEITDFTTARNTKIDVPSSKESTPPKHFSSRLPVKVSFKSSENEPPLKKVKHTESKSCARRQVLQYLSDESIRNNSDVNFVDLEIQNNVSSDDRIKTNFVVAIFYVLYPVASSFSQTLGSNILIFEPNVCENDEATGYSSYGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFN2</accession>
    <name>A0A232EFN2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004963">
        <property type="protein sequence ID" value="OXU17170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFN2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="27" mass="3527" checksum="21EA6D26BB0C49B2" modified="2017-10-25" version="1">MYIFAFRIQEKHLFFIFLTIFYFMVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG77</accession>
    <name>A0A232EG77_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004834">
        <property type="protein sequence ID" value="OXU17360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG77"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8107" checksum="5AA55D9207396DDE" modified="2017-10-25" version="1">MRNKYDISYQQQALMSFMTHDPVRNTTHSLELAKLTSHAVRPQHKVALTQKGDRGILGISMPGALGRGVPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGD7</accession>
    <name>A0A232EGD7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004786">
        <property type="protein sequence ID" value="OXU17413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGD7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12638" checksum="4602B86652326F6B" modified="2017-10-25" version="1">MSQKDGEMCVLATTTQARCYIKRTRPQRQAGQSGVVAEPRADVICYNSKKPGHFACKCRKKKDDNSKQGENKENAKFKGVYIAEMPNSNSEQAESRVPDEQEQRILSADIADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGX7</accession>
    <name>A0A232EGX7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004651">
        <property type="protein sequence ID" value="OXU17605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGX7"/>
    <dbReference type="STRING" id="543379.A0A232EGX7"/>
    <dbReference type="OrthoDB" id="2431000at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043121">
        <property type="term" value="F:neurotrophin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005030">
        <property type="term" value="F:neurotrophin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990090">
        <property type="term" value="P:cellular response to nerve growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001614">
        <property type="entry name" value="Nerve growth factor receptor TRKA, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF619">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="205"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU17605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="526" mass="58854" checksum="CCB1D0D5C575CAE5" modified="2017-10-25" version="1">MEKENHMRKRRTPARANYDRGPHVTDSESPEMLEMDQTASTPSVNCSEKPGMCGLEAACLKVDATTSKCICPHDKSEPTADLKCLNRSKVSKGPNPIRNIILAPGNGTNVTTVLPESKQVERLEPSRVPEVTGIVMGCVLVLALLFGLIYYCKRRNFNAKSKRGDLEASPMNLKTSLLLANKYTPNPQYFTCASPEVPILPRDSLVFLQDIGEGCFGKVFKGELTCADATEIVAIKVLKDTASREAEEDFMREVDIMSTFRHDNILSLVGVVLRDSSNSPWMVFEYMPYGDLAEVLRANSATLRTPTPGLQPLTKDSLHWITTQIAAGMTYLSAQRFVHRDLACRNCLVGSGLVVKIADFGMSRDVYTCDYYKIGGSRLLPVRWMSPESVMYGRFTLESDVWSFGVVLWEVYSFGKQPYYGHNNEEVVKLILQGIMLIPPEDCPPYVCQIMRDCWKTEPRDRLRFVDILEKLEKAQDKPSQISSLPRPPQGPVTIRTPDALDCDGYLLPSPAAMREYLQPLPMITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHG7</accession>
    <name>A0A232EHG7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004495">
        <property type="protein sequence ID" value="OXU17817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHG7"/>
    <dbReference type="STRING" id="543379.A0A232EHG7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10249" checksum="01F28479EF2B9F98" modified="2017-10-25" version="1">MTRASVAEEDLRGWFTKIEKYLKEKHLFNAEPSRVFNCDETSIQLCPTAGKVLAPTRASTVYTVILFPYQEKLSKKCSSASCWMGYRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHK1</accession>
    <name>A0A232EHK1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004472">
        <property type="protein sequence ID" value="OXU17847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHK1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="14379" checksum="04A3FD89157B21DF" modified="2017-10-25" version="1">MGLSILNGNIEGDEEGEITYVGGMGCLVIDYGIRNEEGRRKIKRMKVKDRIESDHGVLDIEIDAETKAEVVKEETSRSLWTEKAIIEYRNCLEKGGEAKSWRELEVKIRNAVQTKRRVRKKNEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHV0</accession>
    <name>A0A232EHV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_012801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004397">
        <property type="protein sequence ID" value="OXU17950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EHV0"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="1271"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="812"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="911"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="967"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1068"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="967"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU17950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1400" mass="157403" checksum="C0ABFF2A033CE189" modified="2017-10-25" version="1">MKNFQFTVLEPCHTAKNSKESVPPIPKPSTFRVEEASTSSRGSDNTKIRASDKGRAVLQKKSFTPKTRTTRRTSNTLHKYLSAKTIGTPDDEKVESQDKVESWLQFIEPADADNEVIDEINRDIIEDTDNEAIFNPEDSPLSEHKHVNQSSTNKSCFTETKQSCEKPLPHTYPSISKGITKYKETEMRIQEAEIMAKKKKLNQALTDKAILKTPSSVPAASHSDAHDWRRVKRVGKEMQVKTFKSLNVSKEKSSSSIVLDDTVPCNLKTPERSRNVFDLSNPEIIPKAKGSSPSQINTNHRLQENELPGGESLNLESKSNPIDSLNSPPKRKLSLKMKSSDSTSSKSTRSHASTPDKIHLNKTESPTKITTDRPKSRLSLRLQTSKPAEHKLGLKKSSNENQNPTRSNEHKLSLNKSPNKNQTPIISSEQKSSQKKSPNKNQDTTKINEHKLSLKKSSNKNQNPISTLSTDKSKSARLPNSKIVLFKKLGKICKKPKYIPFKKLGRLCPRVTVGKVKVISNQNVNVDISCIKVKRKVKETSNEVKMVLPEEDSQLKFFTVEASPCAQQVSRKTFDGKSAVHESAANETHQTIMTMEIDESLPSVTIITSQRKQTKDNKSVGRDDEHSETTNSEPPTSNCKKPEEGIRSNVNERKFDDISSKTCEKVDEDILTTNIDGKSSKKCKNFESSNHENLQTNLKIVEVLHDAISINSNESESRHTRKQADCENIDLNRKNKHPEVESETSDSSLMYVPKQKEKFDENKSVFSSRSSSPLRTSPLKKKRTHSESSNDDDDDLVTSIIGKWTNAKPVIKKPKVIENNQKSFKKSKNKSNQLENSDSDDNEQTLVEDESKQPEFVMPQRDPPIDDIISKVKSFKELKEDNYSVNKLTGLPISLQSADLFESNDSRLRVEANKQSNEITSDNSSVSTWNPNKESDKENVDQSFEAEEPRSETTVVDLLQFDGKKSNGSICSNSSNKENNACNKVNADNSKIKDQVNKVESSPNEKSIADKSHDSPLDLYHVPDSLMNITQEQLILKMIEKELMGADVSTVNNENRDSCESNKFATPRRKVANSRAGNNDDDFDSESIDATPVAKKRRIFRQCQSKSSADAGINSSEIFSPEKSLQLIAAVTPMRNRTSYPLCHSTPMMINTPSPEKQSRPQRKPMTLICSGLSPSNIKIVQNFANKFNATFLVTFTEDVTHVIVATDPETKLGQKTLKYIQGIAFKKHVISFQWILDCLDENAILDEDDEKYDVLDPEICECGARRSRNRVQDLFENFAFYCLEPFSSISLADLKSLLVYNGASVTSTVKELSLRKDKYRVIILESEELCPKKLAALKKVECVMVSFEWVVDSISQYQIVSLFTYLHETSPEEAIAVGLPPSYLTEEVVEEEEEDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI03</accession>
    <name>A0A232EI03_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004375">
        <property type="protein sequence ID" value="OXU17986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI03"/>
    <dbReference type="STRING" id="543379.A0A232EI03"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="136" mass="16251" checksum="719EE2D08864CF74" modified="2017-10-25" version="1">MHVVYGHDIHQRCNDEYFPEGTHLLGDSAYILQKYLIVPYRDNGYLTVEENFFNTSLSRSRMMVERTIGLLKGRWRYFLDKLPMKRTDLIPYYIVCARVLHNLCLKEEDTFEYPLIIPNNLDLNLEPLNVRNELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-07-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI19</accession>
    <name>A0A232EI19_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004375">
        <property type="protein sequence ID" value="OXU17984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI19"/>
    <dbReference type="STRING" id="543379.A0A232EI19"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="34"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14452" checksum="D3BA2A344665303C" modified="2017-10-25" version="1" fragment="single">SCYTSRLHETTLSFFFLIGPRTLSARAASASRLPAQTHRLPELQELLGSKDLLKVGVASFDDEMKIAKDYDCQVVGTVVLRMLTQQNSLPSSKSLAELCVYYLNSELDTILEVKYSNWNKDSLTVEQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIH6</accession>
    <name>A0A232EIH6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004225">
        <property type="protein sequence ID" value="OXU18177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EIH6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15082" checksum="8F7538BDF9B7AF3A" modified="2017-10-25" version="1">MYPRSGNPQHYTNKQRGLLLLLQDKNASIETFLQDTHSFHIHALNSSRSVNGEYKILFPILKSYPDKFVQYMRMQVSTFEYLLLHLLRNGVTYMFNLVLTLRFLATGSTYSHLAFSFKMGVSTVSAVVTXI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIX0</accession>
    <name>A0A232EIX0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004142">
        <property type="protein sequence ID" value="OXU18310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIX0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12336" checksum="1B4995DEC04A65F9" modified="2017-10-25" version="1" fragment="single">SHLCKLSPEPKARVSKARYGLFNFPPVVEILFLFTPAPKMHIPFQAPGRECGIFGAGVKKKHLFLYNEKCEHQYKSKKCVRSSNHVFLENVRMDVCVCIPQYFWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJI6</accession>
    <name>A0A232EJI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acid-binding protein, muscle</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">M-FABP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds fatty acids in a 1:1 molar ratio.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003987">
        <property type="protein sequence ID" value="OXU18530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJI6"/>
    <dbReference type="STRING" id="543379.A0A232EJI6"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19852">
        <property type="entry name" value="FABP_pancrustacea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU18530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="132" mass="15028" checksum="62F36BF0FA740F78" modified="2017-10-25" version="1">MTEFLGKRYKLATSENFEELMKALGVGMMTRKMGASVSPVVEVTENSGEYTMKTQSRFKNSEIKFKLGEEFDEETPDGRKVKSVITLDGNKMTHVQKGEKETVIEREFGPTEMKAVMKVDDIVCTRVYKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJK8</accession>
    <name>A0A232EJK8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003976">
        <property type="protein sequence ID" value="OXU18547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJK8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="99" mass="12053" checksum="DC53FEF381C05C74" modified="2017-10-25" version="1">MDRKSFTTHYSLDKHFEHNLDQSIRRWWTKLDTTEQQRLSFAFSTIFTYMKNNDYEKLYDYIGMSLEQFEYLYALVGNKLEKRSRRTPLPTKLRLAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJQ1</accession>
    <name>A0A232EJQ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_008165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003979">
        <property type="protein sequence ID" value="OXU18538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EJQ1"/>
    <dbReference type="OrthoDB" id="6357915at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1230"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1122"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1139"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1522" mass="167973" checksum="A40CADDEDBCBCEB3" modified="2017-10-25" version="1">MEDHTGVYEQVIDASSTNPGSELVSSHLVQEIVVENDDRESSMNCGLSDGSEINLKNDSTNIHNNIETIKQDQICENYKNLASDNPRHKEQNIDNSVPQNQASDHKGITDFNDSTSDAPKSETDCRESIAEAILDPNESVPVINVNDTVPNLSKNQTLDDYNVLNNDQNIMDNLVTIKDEHTDKCDQAMGNIVTNKKETDSIIDNMQSEKIESMEIKSVSIDSEGGNENVNIAIEEIPVKSHCTDDANERYDNLKFKQLNSEITEEGDHPVLIEESIKATNIVINSDDVAVLTEFSSVEYNIQTEITKKEGVKVETEHKLHQITKSGTIKNSQDLTDNMLSIDMNNQESKHNDVSIYDELTNEEDEDELNLHLSSQSTENHRKVIQDIFDDWQDENGEEEVNQPSSTFKDNHDSVELELQSLLNDGAQQEETDSSINIEVTEKSSTENSKTKFVKSDKLSQLDKTAMEVKTFAQNKSPKLALNSTSIKDLSLGHLPRTLSQDELLDQKQKQQSPRPGVKVPGIHLTSQIASTTEVNEALKERLREKQKDLVTPKTVDIVFVKKITQRLSSQLSGAVSVPPLIPLQSTPITENHKIKDNKSETSEDEKFNKISSSTTADKELLAILEGDVDPDWSNLKSVTDESNKVSNSGEPHSTDVCTRPGSKLDPAVERELALKQLLELPNIPAKKNNPVSLKKIKKTGRSSNVANEVLESKSVDEIKTEIISLDSAEEESPKKSKTPKALKENNNQNMHRAATDTVIIDLGVEESRSGRKRKLTEKAREHELSVKRQKVPKVKPGPEKKSLHEFSENSKHMTDFDSPAINKSTNTSKAALEPNSSSPPKCSQTKLDAKQNKPEVKQSKVDIKAASSKSEIKQTGAKMAGTKGKITLVKPSKIGLLKKDVPISKRKLAVKNLLRQKMADKKSSIVRTKGQVSEKSLATGLLITKPKKVVTEIDKLLQDEGVVNLLYDVEQPDLKKRLIPITKSQKKVMDVEKAERELKLRTKLVRNAVLRLRNSNASAVKISPRSRRNMSVTENVSTQSEKKCGEPTKSPKSPVFTSASSDFIIPAKIRNAADASRIIRRHSSSSFSSASASPRVSIDMPPESIKLDESDLQTKSKRKLSHDSVEKPDTRKIKKKLAPKEEIKDTESSEKSSTKKELAKKITTRSNITSVSSTASIKTVCKNKKVPKNKTSSETLTNDAKSLKGQDELSACLAEAATALLSGISTIGSSRLSSGSTSRKKGSTNFSKTDDERVDSKKLFSNKEINVRHHGHLVQLILTPSTPVSGIRNAITVQVMNEMREALSILKNDDDCRVVLFTSTGTSFCEGLEVSALLQSNKDERKVRAEETAMAVKNFIKELAAFNKPIVAGVQGAAIGLGVTMLPLFDLVIASDKATFSTPYGKLGQIAEGAAVLTLSHSLGSAVTNELLLGGRVLTASEALRAGLVTRVLWPDRFQGELLPSLKTMSEQSSQSMEATKALLRQSLRQKLEMALESETLLLVKHWCSPECQEAMKIYIEEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJR4</accession>
    <name>A0A232EJR4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003970">
        <property type="protein sequence ID" value="OXU18558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJR4"/>
    <dbReference type="STRING" id="543379.A0A232EJR4"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="189"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="308"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="399" mass="46391" checksum="BDAD9756B05DDCB7" modified="2017-10-25" version="1">MRRLSRGKQRKSEANSDAEEEVSGSAKTDNDETGSGNDVEVSNSTGKKRNARGRVKTSEENQLDDKEEAEGQENGKPASKRRKKDSDENVESEKAESDNETEKPVNKKRRGKQQDKDSSKAESEEEAEKPVSKKKRGKQDKDSDVSYEEKKDKTEENGKSAKGKKKGKAARKEDPKEAEDEVEEDEEEYEVEKIIDQRTIKGRRQFLVRWKGYTAESDTWEDDKELNCDRLIEEFLTEQEEKDESHEDDENERTDKKTKGKKPDKKSKKAKKPAAKAKNGSPKQATKHKEKEKDADDDDEDEDDAKEYEVEKIIEVHFKKDKKREFLIRWKGFSATSDTWEPEENLNCPELINKFMEKLDKIKNIESRELRMNPSHTKRYTLTMHADKRQSRRHADKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJU3</accession>
    <name>A0A232EJU3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003952">
        <property type="protein sequence ID" value="OXU18598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJU3"/>
    <dbReference type="OrthoDB" id="7699847at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="219"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="320"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="620" mass="70747" checksum="9336CB0C2CFCF233" modified="2017-10-25" version="1" fragment="single">LVEIRKTFITAFYVRKSMLMECSSDVVRHNLKLRRRDLNVHSNIEFKENGSRLFDDANDDFCAHTNNNGVYNDENVDCNEQFDDNLYKEIIETIENIFGKEIEGEGLKYESLEPMTEKELLEVLIAPNHAESTSEDSKKILSTSELIEILQLSENEQKDPCFENGQEDLCFESLSSNPVQVVEEKNIIQHSLTNNECLVNKSTDDTQRSIVQMSSEPDRLDSKSMSLNSSSVAGSITFGNGYSQLEKLLASMHVHCIAPTTYIRNHDLLLEAFKISAEKSMHIAGELELEFAKKSRSYKNGMPCIRVVGDGELELEFTKKSRSYKNGMPCIRVVEDGIFLRRTFPNGRYDSNSGMAIIVEYHTQRILYIGIRNKYCFVCARAENQNIPAKKHICYKNYSSNKSASSIETDIITEGFKQSVTQHGLIYEYLIADGNSSLYNQILQDDPYKKYCISVKKIECTNHLLRNLCTNLKTVGKGRKKLSKWRKLIEDKVLRIRTAVTKATEYRVKENVPETKEGETNHVKEMEKFGIFTEIEESFSRISSNCLSLLQQLNNNIVERCNSVLAKIINGKRINYGLKSSYECRAYDSVTQSNTENTLSQVAVALNKTSNDIKKEKLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK03</accession>
    <name>A0A232EK03_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003902">
        <property type="protein sequence ID" value="OXU18689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK03"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="8854" checksum="26D61BA210E22866" modified="2017-10-25" version="1" fragment="single">MCITRIKVLKESFNLRTGKLRIITCVKSCLGLKIAKNHKNLNFLRKSCLGKKKYFVIAGTQGFSGSRWPKEPKKVGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL72</accession>
    <name>A0A232EL72_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003620">
        <property type="protein sequence ID" value="OXU19095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL72"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="118" mass="13916" checksum="2565906C69F18FF6" modified="2017-10-25" version="1" fragment="single">MMLILFTLGTRYLKERDDVILSTLGTRYLRERCRHDIRVLQPQKSPSSKTGLISINIYGRKLCNIFYGIEKHYFAFFFNHPIVTNKSANLHLKENKITNFFPFCPRDRPLCSADKMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELN4</accession>
    <name>A0A232ELN4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003521">
        <property type="protein sequence ID" value="OXU19273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELN4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="29" mass="3548" checksum="9AEDDA2AB1DAFEA7" modified="2017-10-25" version="1">MLRIPVKFSEMTFILFTMGNRRCRREICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMB6</accession>
    <name>A0A232EMB6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003397">
        <property type="protein sequence ID" value="OXU19481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMB6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21635" checksum="AA10A1783492D9BF" modified="2017-10-25" version="1">MSEQLDKLIESGIVQKSHSAWISRIVMLKIKVGNTEFEALVDLGAARTIIGKHGKEIERRLGAEIKPTIYKNAVIANGSPEPIDGEITVAFEIAGVSKRALILVTPGIPTDFILGIDLVRLFGMKIDARRDTFKLPDRKDKKEIAFEVWSIDTCDSPINVASCRISQISASEQQQINNLINELLPSDGQNDKILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENH2</accession>
    <name>A0A232ENH2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003150">
        <property type="protein sequence ID" value="OXU19904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENH2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="16" mass="1858" checksum="F91CA35273501511" modified="2017-10-25" version="1">MLLIVEIWVLKLTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENH5</accession>
    <name>A0A232ENH5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003166">
        <property type="protein sequence ID" value="OXU19881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENH5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10387" checksum="63A46A55ECD607DB" modified="2017-10-25" version="1">MAYFAQNLTVTLVLNWREARRRRREKERKNLREAVNRANGEGNSTVGLYAREKKATQQRRATTVAITLPPAVLVVSTLLNPPQNLTFWHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP02</accession>
    <name>A0A232EP02_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylglycine monooxygenase</fullName>
            <ecNumber evidence="1">1.14.17.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_006431</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O</text>
            <dbReference type="Rhea" id="RHEA:21452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13486"/>
            <dbReference type="Rhea" id="RHEA-COMP:15321"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="ChEBI" id="CHEBI:137000"/>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
            <dbReference type="EC" id="1.14.17.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="10">Binds 2 Cu(2+) ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.3" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01003041">
        <property type="protein sequence ID" value="OXU20068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP02"/>
    <dbReference type="OrthoDB" id="10044505at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004504">
        <property type="term" value="F:peptidylglycine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000002">
        <property type="entry name" value="Peptidyl-glycine alpha-amidating monooxygenase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0186">Copper</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="13">
        <location>
            <begin position="81"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="105"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU20068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="238" mass="27086" checksum="0FE77B208C3277FE" modified="2017-10-25" version="1">METKKVFDLFLYNAWSIIYAWARDAPALILPDGVGFKVGKGSLLKYLVLQVHYAHIDQFKDGSTDDSGITLHITKQPLTKLAGVYVLGTGGGIPPNSIENMESSCKISENKTLYPFAYRVHTHSLGKVVSGYVIKNNEWIELGKRDPLTPQMFYNINYNGTITYGDRLAARCTMKSERDKWTYVGTTNNDEMCNFYLMYYVTDDEPLYDKFCFSMGPPRYYWRKDGLINIPDSEASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPB8</accession>
    <name>A0A232EPB8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002977">
        <property type="protein sequence ID" value="OXU20193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPB8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7193" checksum="FEA0F4EB7C2DFAAA" modified="2017-10-25" version="1">MRAQFVLFLSVFLIKIVLWCYYLGKSLINRAKKFVCELSSFILGLILHVYAECGHLQKSLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPM0</accession>
    <name>A0A232EPM0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002915">
        <property type="protein sequence ID" value="OXU20329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPM0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="218" mass="25113" checksum="E8449D136EF311B0" modified="2017-10-25" version="1">MSNRGPKTNISHEMRVIELQKHNIFYENGKVKKESDPVWVKISANLNKGLDPKEKPISVRNIQTYVAQNRNHVIQDIKKDSANTSNLRSHSEVNKSDFNVEERLLKIKNNALYKPIIRELCTYPFIVFHWSFEALDLVSNFKENVFIFGVAGSPCQPFIAPDKTVSENIFLFTFGINVLNEHISICEFSSEENSVSLVNRFFYECLRSGLKIPKKIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPR4</accession>
    <name>A0A232EPR4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_000626</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002920">
        <property type="protein sequence ID" value="OXU20296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPR4"/>
    <dbReference type="STRING" id="543379.A0A232EPR4"/>
    <dbReference type="OrthoDB" id="20573at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1440:FF:000001">
        <property type="entry name" value="phosphorylated adapter RNA export protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="12">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU20296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="418" mass="47948" checksum="AE74DCD35174C232" modified="2017-10-25" version="1">METETLELEDGEVVDDEPIDAFEAYNVLQRPHSHVPPVPEQSNKLRYSDDSDVSEASESDSDSDAGHCRIKRPKIKIKRCKTLNQQSRSNDKYKVWCTQVQEESLTEDLVSCGVTRSLYHDRNVESYDYTMGYSLNKKSRDNNTSDEDQEAEPRLTNKRTFNDRRNAKLRLGKRSKSHENEEDPKGAARILPDLIVTTESSVDEVAADIADKLSEKKDTLIKRVVEILGKEQAIDFFQRTKKIEEEGGMLIMNGSRRRTAGGIYLYLVKNDDHIPQPKIREIFYQDKRENTDRKKMIETTHRKQQTQELMKLLENGSNKDLPALLNRAELSTRQIAEEARLRRGEGMDRIPIDSDRTVSNPPPSPVTDDPDHSEPPNPVCSRRIQEYGDDFLDIGVEVDMEEPCNFDNVLAIKELKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQZ3</accession>
    <name>A0A232EQZ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI ethanolamine phosphate transferase 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_005270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002685">
        <property type="protein sequence ID" value="OXU20780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQZ3"/>
    <dbReference type="STRING" id="543379.A0A232EQZ3"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="812"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="888"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="516"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="730"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU20780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="920" mass="106660" checksum="D9C3B12310A5F825" modified="2017-10-25" version="1">MKNFKRRSDDNKTSYRDYFMLNYVIVASMFSILLFLYGFFPLSYNDHSIATRKDIPKFIERTRVKMDEVYKPVVKKVIIMVIDAMRWDFISGPNSAEYMPMTHDLLKRKEGCLYKTKVNPPTVTMPRIKAKTTGSVPNFIEVVLNLGATEILGDSILRQSKYQGHKIIFYGDDTWLKLFPDIFDRYEGTSSFYVSDYTEVDFNVTRNVAIELHKKDWSIMVLHYLGLDHIGHIAGPFSPLIKPKLQEMDNVIGNIEFYVSEWNKNREETVFIVCGDHGMKDSGGHGGATLEETLVPLMVFGKSCSNKKNPNDHISQIDIAPTLSVLLGTPIPSTSLGTIVLDLMTDLSLSQKLFALYYNAEQLFLKYQKFSDYQYTGTYKNYQNAIKLHAAWLNTNSQPNDMVDDIIIMYESAIIDMKKRLTSNLLEYDVQVLTLAIIFMGQILYISTSTEKSTPISYKQFLTIFVASYMMWMFLNQIFDSGTTTVLFSQRLDLHFLFVTIPIFGILALNCYLCATRAIASDKTRDWPDLQWLLMIGTLFHTISLASSSFVEEEHQTWYYYWITLVTFFAFYHFRKNINAKQKSFKLLAKLMLLLVSHRILRKLNSTGDKYAHLPDISGWLQNRPCTIEMTTILLFGLGLLIWLDYIYEDEENRPIVLLLDSILAILVYLRHAIADTVFLPSFYFDSRGLIEMYYFWAFTLIYIVHSIYRLGAAKRHNKEKYLCLSLFLLVKKWVIVSSILHRPYNVILLPMQLIVGATIFELTNEREFSNAKLFIYLWCSNVFYFYQGNSNSLATVDVAAGYVGLESHQPVITGIFISINTYSAQILGFLMYLCDYALQYPRSTSKSMLLLCRQYAFWRLVPITFYAAVTSFQRYHLFVWSVFSPKLLYEAMHCAVLLSVMFLLQFHFILCDRVRARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERJ9</accession>
    <name>A0A232ERJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_015350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with the U2AF small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002580">
        <property type="protein sequence ID" value="OXU21003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERJ9"/>
    <dbReference type="STRING" id="543379.A0A232ERJ9"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="246"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="355"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="453" mass="51807" checksum="36AEA8F76A7917D8" modified="2017-10-25" version="1">MGEDFNGDRERQDRDRDRDREKDRERERDRGDRPDRGDRERERDRDKERRHRSRSRERRKRSRSRSKDRRSRDRRRSNSPKKSRNSRRRKLSLYWDVPPPGFEHITPLQYKAMQAAGQIPANIVADTPQAAVPVVGSTITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLSGLAQAAGNPVLACQINLDKNFAFLEFRSIDETTQAMAFDGINFKGQSLKIRRPHDYQPMPGMTDNPSMNVPDSPHKIFIGGLPNYLNEEQVKELLMSFGQLRAFNLVKDSATGLSKGYAFCEYVDVSMTDQAIAGLNGMQLGDKKLIVQRASVGAKNPMIGAQAPVQIQVPGLSMVGTSGPPTEVLCLLNMVTPEELMEEEEYEDILEDIKEECNKYGVVRSVEIPRPIEGVDVPGCGKVFVEFNSVLDCQKAQQTLTGRKFNNRVVVTSYFDPDKYHRREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERX1</accession>
    <name>A0A232ERX1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002544">
        <property type="protein sequence ID" value="OXU21095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERX1"/>
    <dbReference type="STRING" id="543379.A0A232ERX1"/>
    <dbReference type="OrthoDB" id="193905at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005119">
        <property type="term" value="F:smoothened binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028784">
        <property type="entry name" value="BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032728">
        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056419">
        <property type="entry name" value="GAE_BBS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14779">
        <property type="entry name" value="BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23304">
        <property type="entry name" value="GAE_BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bardet-Biedl syndrome 1 N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Bardet-Biedl syndrome 1 protein GAE" evidence="2">
        <location>
            <begin position="477"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="580" mass="63446" checksum="E9DD8E48C7A34A37" modified="2017-10-25" version="1">MERTGLSTSRWLDAIWEPNTRMYTLPNGIDMLDVTGDGDARLIIADLGSSTLDDTKLRVFKGADQATEHAMADVPCSVVGFYTENGEKKSAALAIGAGSSVFVYKNMRPHFKFCLPQLSAHPREQDIWYKAGLDEELNILSLADDLEVLQKEIGAAYLTSRTLKFLSLESEARRSFAEQYRRLPLVKTNAISIVGAIRKDSWTDIACSYLIVGTEFGDILIVDQRLVAFFVVEKYTIGWPVVALTTSGLWMGDGQIVMTGRDGRIGAIKKGGKFKPWETLSAPAVAIATLTCEGAAIAAMNGTFSAFSKKGVKLWKVQLPGNPLDMVSLPVPQSGLSLLAISIANLGVRIYDQKHLVDTIKTLESVSSLKYGRLGQEERAMAMVTCSGGLSVKILKRTADFSTRSNLQSNFDSPSANAKFLIPKKTKLFIEQTIRERSEAVKIHTSFQQGFLRLRLDAAIRAREITKSRHESGPVPITLQSSVLGLGPSYIVKIVVTNIFEGYSSADLFLVCRDENASIKPRVVKLPLLATGIPLPVTFSVTPQGRVSSKIQVLLCSKGQIRPLTVTNVLLPVAEEDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESB7</accession>
    <name>A0A232ESB7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002449">
        <property type="protein sequence ID" value="OXU21253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESB7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12434" checksum="674B2852F5F0A941" modified="2017-10-25" version="1">MTKVHKPLLVFKRVTLDRLKAVSKIIDHRIKYLLNVREAITIIVKELGDYSKDKLVNSENVKYTYFTASNFERAMRAFDETLVDKIDQLLEDKNIYSTLEDINLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESH7</accession>
    <name>A0A232ESH7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002440">
        <property type="protein sequence ID" value="OXU21267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESH7"/>
    <dbReference type="OrthoDB" id="6365737at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10331" checksum="12E1DF33B16EBE1D" modified="2017-10-25" version="1" fragment="single">VDENLAKVIQGTYSGRGISTILVYPDKCICQRPYSHVICLNCGHLMFGRVRYQCPKHKMVTFLIDITHCPRCRCLEYMLSEFSKEDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESK2</accession>
    <name>A0A232ESK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_003961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002414">
        <property type="protein sequence ID" value="OXU21334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESK2"/>
    <dbReference type="OrthoDB" id="7179992at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="76647" checksum="F59D38C6C07F5402" modified="2017-10-25" version="1">MIIKSIILSKCQKYPAISINGVMSTLYRKIYVSPKKSFRVLRFVGIILRVWPVNDKKWNYRTDIFFWFCIINCALLWVPLCNALYLNHKNVVTAAISWIEVSWFAEITFVLIYSKYKKLQLYVLLSQVERCVYLRKTNIIKQYATIYAMIFFSVMLFYLLAFFVYMSIERPNTGYNTLITTAVYPFDINSYVAKAILYCNQIFLLTYAAIAPTFDGISVLLLFVCTHRINILDHNFRLAKTLSDLAQCIREHDDILYTIKETNSIVRILAFKTVCSFMSNVIPAGLEILNSVGLSQSILQICTILLVYTRIVLCSESAGNMTNAAEDLVFTIYSSLWYDEEPKIVLTKTFILQKCQNIPAIHINGLMSGLDRKYLLANYYTNHDNSLIEKVVLKNKEIKAWNVKTALYKSASVMACVWVYRVIVRSLHYWEFKVAMRYYRQLRELKNMASIKSLLTLVLLFIARRTYQRARVPIEVDVQEGETDDPSVDDSENEDAGPSPKRARIEDLRAVHSPGRISLRGVGSDKAIATASRKVNLQIRNDFESFKMKNVLVIDSLALPPQRVSKEMVEHYQIKTGIVTRAYDASPMLLIGQENCSLILTREHREINSDVYVVFRCILGWSIHGFPNKPSKIRQINVVGNSIRALCISENFWLPSLLTFKHANQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESQ0</accession>
    <name>A0A232ESQ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_015106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002392">
        <property type="protein sequence ID" value="OXU21379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESQ0"/>
    <dbReference type="STRING" id="543379.A0A232ESQ0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF188">
        <property type="entry name" value="NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624341" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU21379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="566" mass="62759" checksum="4E744F08EA6FD1AB" modified="2017-10-25" version="1">MWNYLLFSALVTLVSLLFRHNLSSPISVVDHPETQYDYIIVGAGTAGCVMASRLSEDPNVTVLLVEAGGYFNWLSSIPLAAPALQKTHVDWGYKTESQAFSSRGLWDHQQRIPRGKGLGGSGQLNYLVHSFGRPEDYSNWPRGWSYADLQPYFKKVASTMHVQQIISDEQGLVQAMDMARETMNETDTVFIRPQSTLFKGSRWSTYQSHLQRAWNRRNLHIVMNTVVSRILLDSKNAIDGVEIQYEDGMREKIEAKKEVIVCAGAIATPQLLMVSGIGPEDELKKHKIALQVDVPAVGKNYADHFNMPVYVNLESPVSITLKKMQSVSTIVDYFLHGTGLLASNGIMGMARLDDSAVILAGVGSADEKLLKDLSNYRTETFRSLFPSYSDITREGFLFMSNCQQPKSRGNVTLRSASVVDRPMIEPAFLERDEDIACTIKAIRLGLSILETPLFREFGAEAHVPDLEECKDLVQDYRDDAFAECAIRVSALTSHHPCGTCRMGDSNADNDTVVDEFLRVYGIEGLRIVDASVLPGPISGTPNSVIIALAEKAADIVLNRSPSSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESY0</accession>
    <name>A0A232ESY0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002361">
        <property type="protein sequence ID" value="OXU21463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESY0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11551" checksum="357751858A0B58A1" modified="2017-10-25" version="1">MMSGHAKKSYEPKILQQLRAVEYPKLCSELDDTFSRSSIGDKIAVVCSGKPFHLDKSNNFKGTVKTVANKSNKRISRSCKQHYTANIRLIKIVYCFLPKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET27</accession>
    <name>A0A232ET27_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002343">
        <property type="protein sequence ID" value="OXU21508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET27"/>
    <dbReference type="STRING" id="543379.A0A232ET27"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF133">
        <property type="entry name" value="POLY(A) RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="459"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1089" mass="126905" checksum="9ED5B1C5B11B2316" modified="2017-10-25" version="1">MFKKCLENRIVCRCPGFKCYLCHHEIQDKNFIAVEKHIETDKHQQRINGIDKTMRAEVSRKLETVSEKQRGIIAKNQITTDVKHNFLYCHICKCSISGISNTLEHIKGSCHARNFSAIENKNQMNMPKNSSTNQVGCNHLTNNDYITLDKKTKWFKCHACNCQISGSENVLQHTQTKLHKDAANAIKDKKIFKLVKQSIDHNVSVPTKSKDDFMEIRFCTSCQINLKNTAMLQFHSLMHFYKDVKTPLILDIIKFRFDQHEKAIIQCLLCNTFVYNNEIVDTHFRSPLHLKRLKFFKYVQDDIELDDADNQQINLEKMNFKPHKQISKALLCTLCDVSVSTAADKKDHLQGKKHKKNSLLPLENKIEKISNKISVADYLYFYPCYLCEKSFINAENLLDHYQEKKHKLKLKFFRLVTKNPYITFIQVKSKQAAKCRLCMIFMYDCTSIINHTLGKKHLQREKNSDLPMTSRNSSSDNSQSTNNNKIVTLRTVPVKPSSSKSSNPKQKNNYETSTEELVKLGFSVENLNSATSIESISLDVDDALNNLISLDLTVSQKKKLSRSSRVRKPRKPNAEGKKTISSFNQSAYIWGKSYIKHCINLGAYNIYNINPDKLRLLKLGTSLIFPWQSEHACLVCGEQFVNQQILFEHLQDAKHIENLQLMEESDKEFQFYDKQFSDLELAKNYMQEESNDLVHCYACENKVKNDDTYIRLHIAELNHINKSQLWRKLSDEIYKNLSVIFEEAWYYAQVFVCDICKIKNHMEIDFVMHLETQKHVQNVTKLLQKGIMTKFGMCPVCITCWYASSDFYTVHCQDQLHKRFAKNGDFMIPNMTITALDLLVNVDEQIDFLINESNKAVLEKYKETELLKAIEETVESIYPNAKAHTFGSRLSHLGFVDSDVDVFLDCNNLYYSRTTKEQSQHYLMSVKKNFETKPNIWIVDEVLLVTRVPILKLRHIPTMLKCDISFINGLSWECGFVDNFSANHSDLNFREHLKGFFNYYAEFDYKTYVACPYLGKIIKKHTFAYKDELPIEMQIYKYRLQLNYVETFRFDSPMCIQDPIDLSQNITKAVKKHHLRCFRQYCTESAAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETT1</accession>
    <name>A0A232ETT1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_014022</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01002226">
        <property type="protein sequence ID" value="OXU21770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETT1"/>
    <dbReference type="STRING" id="543379.A0A232ETT1"/>
    <dbReference type="OrthoDB" id="10064699at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22768">
        <property type="entry name" value="OTU_OTUD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF27">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="17">
        <location>
            <begin position="119"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="18">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU21770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="555" mass="61875" checksum="15C5CA92A150CBFE" modified="2017-10-25" version="1">MSLHDTAMSGALSMYDALNQEGGSSGNSLQPPEAGATKKLARGISRATENADIVTHARLQLALGSIDTPEFTFSLPDLSIYPDDFRQFLEKDLIEGGCLASLEAAGRLNWWCGGKNRVLWPLATTGDGNCLLHAASLGMWGFHDRELTLRDTLHNTLSKGEYRLALFRRWRWRQLGLNAVAGLTYTEAEWVAEWQAIVDMASTHPRNQMSTSYQSLEEIHVLALAHILRRPIIVIAETMLRDSEGVALAPIPFGGIYLPLEVPPPRCHRTPLLLAYHSAHFSPLVTVDSSSDPSEGSIEGYSIPLVDPDTGQLYPILFAVDPGPDWVWTASQDLLACQPDTMEILIKEYLDCEYQVFTPDEIDRLSESDAAKSKTAKQLMGVAKQFGSIGKSVSKKIWFMNRRPKSPPSSNSGGYGDTLLCVRIRSRRHQYADQMLQNYLESAHARYLQDHQGNNPGSEMNYGAGKSKFYAASDSNSHASVSKLPATNHKKDGTLYLSRSTFYNDQVLPEEPKTDLRGNIDSDLVKRCRTQDCKFFGSPENQYYCSQCWADRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU28</accession>
    <name>A0A232EU28_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002173">
        <property type="protein sequence ID" value="OXU21869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU28"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="13116" checksum="0811C9BD0DDC5F77" modified="2017-10-25" version="1">MIKLDFYTKSSAIYEDKFLGEGIIVLRPNCQSIINLQKQNRLFEVHRSKLTLSINQISLEDDQLDLNNLFVEISQIILSKLDSDSLLNCALLPQPRRQPSSTKSILKKTSRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUB7</accession>
    <name>A0A232EUB7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSAR_014116</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Alberta</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Microsome membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002144">
        <property type="protein sequence ID" value="OXU21942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EUB7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0408">Iron</keyword>
    <keyword evidence="22 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="25">
        <location>
            <begin position="243"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="25">
        <location>
            <begin position="394"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="24">
        <location>
            <begin position="645"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OXU21942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1345" mass="154684" checksum="1E275379FC0BCCBA" modified="2017-10-25" version="1">MGYDTEMDGCGRCMKYTLFVVNFIIFIGGLTITGLSIWALVQKVNYVSELTGNNLLTGTVYILLVSGIIVTVISFLGCIGAAREIKCMLFMYFIIILLLFFIILIGGVLGYVFREKFITTLQQQMQNSMSLYRQKKEITEAWDYVQGQLKCCGVRSWRDWSRYLNEVPLSCCKSYTPDGQPVACNRYADSINEHNAYPWGCVDATKDFMQKHAAALGGAGITLAILMLIADFIKSAMNDGVKPCDDFYSYACGSWAANHPVRKGEDVSSIDAIIERHINHLVIDILEEEENNNDTAALKYEKIFHKSCLDTDKIEEIGIQPLEETVNYFGGWPITMNSSDWNDENRDWQSIHEVYSAMQGLSSIFDIFVHYDQRNQSKWAIELKVSDNETSYMEPPRTYTTIDDLQSFYNEENPTKPTSKINWLQTIRALFRNVNKSENIEIGELEEIGIGDKYFLHGLLHLLEKTPNRVIVNYVHWKFVSTSIKFTNKEMRDLYWQFINIGEDSELVHKSRRETCQADMRIGTGLKYEFLRRHISPEDKEIALEMSSEVRSEMLDEIELSTWLDYDTKQETMIKLHDLKTRVAGARREWTEHVYEDLIIGNNYFENVQNVRKFYTTRMLKRLRKSRDPRKFPLVHPLRVRPAYDKRHGRVVLSAAQLFSPLFHSSLPLPVNYGYLAPTIGNLMARAMEKEVDTNVYVTPWSSYFGENYKSYETKTECLIKQYSNYSVGPATIDENMYDTIAIKVAFNAFRNSFIGENTVMHLPGLEHLTEYQLFFVSYAVGKCQAVTAKYLAEHDPAYFTPNEYRVIGPISNSELFTNAFFCFFQNPENSAPNSVKQSSNMDYWIWSLLVVTLTYAITSIYRQLSYFSRWGIPHPREMPIVGASYALFFPRRHINDFIKYIYDFNPDAKYVGAHIFTKPTIFIQDLDLVKTVLVKHFDHFADRKTFVDEKADPLFGRNLNFLNGDRWKEVRTILSPAFTSSKMKMMYVLMSKCAENFTEEFLKKYGDAEAVDMKDAIGKYTNDTIASCAFGIEVDSMKDPNNEFYLQAKETNFNGVTLLKIQLEMIFPALTRKFGMRIVSKKLTDFFVNAIATTMSVREEQGIFRPDMLQLMMEARSKMDKEASERFDLLEMTAQAFLFFLAGFDASSNQFCIIAHELAANPDIQSRLQAEVDDLMQKCDNKPTYDALNHIPYMDAVISESLRRHPIAFLNRICSKEFELPPAVPGSKPYTMKPGDGLMIPVAGIHMDPNLYPNPERFDPDRFIDKKIAISDVTNLGFGLGPRMCIGNRFAILSMKSLLVQLLSRCNLVPCSKTCIPLEYCKNIFAPTPKNGFWLRIEPRAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUS7</accession>
    <name>A0A232EUS7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002098">
        <property type="protein sequence ID" value="OXU22093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUS7"/>
    <dbReference type="STRING" id="543379.A0A232EUS7"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF405">
        <property type="entry name" value="PEROXISOMAL N(1)-ACETYL-SPERMINE_SPERMIDINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="293"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="591" mass="66254" checksum="76D2B3E157CB047B" modified="2017-10-25" version="1">MHATDSSLMSFNTKRFCHQPLERCLTKTVTDKKVELGANWIHGVLGNPIFELAMANDLISITSIPRPHKIVAAMENGKQLLFSVLEEIYAAYVSVGEHIALETDLYLEHLSPEDRKVRQILFDCLLKRETCITGCDSMKDVDLLEMGSYTELQGGNISLPGGYSSILAPVCKHIPKEKILTRHAVTKIRWHNDAEDKSSSPIKVECDNGKVINCEQVICTLPLGVLKACAKDIFEPQLTTHKLEAIDRLMFGTVDKIILEYERPFLNPGVSEIMLLWDDRILPAEEAEDLSKVWFRKIYSFTKLSDTLLLIVHSILAPVCKHIPKEKILTTHTVTKIRWHNDAEDKSSSPIKVECNNGKVINCEQMICTLPLGLTTHKLEAIDRLMFGTVDKIILEYERPFLNPGVSEIMLLWDDRILSAEEAEDLSKVWFRKIYSFTKLSDTLLLGWISGKAAEYMEGLASEEVARVCTGILRSFLNDPFVPAPKACVHTSWHSQPYTRGSYTAMAVGASQLDIECLAEPLAGPESSKLRLAFAGEHTHSSFYSTVHGAYLSGRTAAQAVLESRRWEKQDSVSCDTTSDLSSWIQGIELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV69</accession>
    <name>A0A232EV69_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_002570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002040">
        <property type="protein sequence ID" value="OXU22252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV69"/>
    <dbReference type="STRING" id="543379.A0A232EV69"/>
    <dbReference type="OrthoDB" id="7635222at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="441" mass="50516" checksum="DCD423645FEDA43E" modified="2017-10-25" version="1">MAHHLELVRENMQKLFIILLVQVLCYVEASDRLHRSKRDESYNRDLWSFECKDKSKRISLYYVCDGYNNCQDNSDEVGCTEERCKQLWRLKCKNRDVCLDKSAICDGRNDCGDNSDEENCTEKRCNELGKFKCKYVNMCIPHHWTCNGRDFCGDNSDKEIDCSEKWCNQFDAVKCKNKNLCIRSIDECNGRNDCGDNSDEVGCDEKRCRELGRFKCKNTNVCIPYKSWFCDGINNCGDNSDEMDCFDREKPCNENGKFKCIGTNKCIDQDLICDGIDHCGDNFDETDCTAERCSRIGKFKCKHGNTTCISDSYVCNGYDDCGDNSDEADCTEKRCHAFDKVACKDKSKCLNPYDVCDGRQDCDDNSDEIGCDDKRCHEISKFKCRATDKCIPSEYVCNGDDDCGDNSDEVDCKKNSDAKNLVPLLNFDVSSNHFKRHGQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWI1</accession>
    <name>A0A232EWI1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001855">
        <property type="protein sequence ID" value="OXU22708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWI1"/>
    <dbReference type="STRING" id="543379.A0A232EWI1"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF114">
        <property type="entry name" value="CARBONIC ANHYDRASE 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="333" mass="38044" checksum="BC8AB072B441AD44" modified="2017-10-25" version="1">MSKKTKKKDETMWTSTTGLPSWKQSPVDLSPMYTLHQNFPPLVLQGHLSSKSCAKMSNTGNTGNRLPFKQMVTSLANVQYLNITLKIEFPEGREPIVRGGPLQSDEYRFGELQFRWGPSDARGAEHSVDGAWYAKIKLFSSRVILSYLITRFIERFSMEAQAVHWNTSYGSLDKCYERDDGIAVVAFLFQVIGCQDMVDNPDFACIADNLSRIKIPDRSVELPPGILIPHIQRYSCNEICKRPGCLNWMTDACSKPGYYTYNGSLSTPPFTECVTWIVIPRSVKISARQANAFRDIYNSQGERILRNFRSQQKIHERKSELSSKIQELREYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWN5</accession>
    <name>A0A232EWN5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001835">
        <property type="protein sequence ID" value="OXU22760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWN5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="7819" checksum="129E071F70F146D4" modified="2017-10-25" version="1">MSNESAAMRTWLSDTFRVSAKPSPAVEQQQQQQEESSAESAGSQSSSFNDKASASQPEALVAQDSRSRPAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWW8</accession>
    <name>A0A232EWW8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001816">
        <property type="protein sequence ID" value="OXU22836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWW8"/>
    <dbReference type="STRING" id="543379.A0A232EWW8"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="273" mass="31510" checksum="A627CC7250288C89" modified="2017-10-25" version="1">MEEVREAIGIDKVDMCGNVIFIEEQHNADANFVLHAITSHCRDTNKIVCFALFHNTFGHFHNVGMKLGYNLRKELNSSVRVIEPLKIISKNIHRENKAYAAPQVTDNKLPEFDIKNQSSHLVKQLAQVIKDECISMKKGLINQKVYVIIDDLSHLFDLGLSFQDIWLFIRYLRSFVNFEPHLTLCIASHVYKAAQEVCHPNITAICLRHFADLVINVQPLETGFSKNVSGKMIVNWKSQQQRLKFKWSEEMIYLFKLLDRQVKLFAPGSSHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX67</accession>
    <name>A0A232EX67_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cyclin-dependent kinase 20</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cell cycle-related kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cell division protein kinase 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">TSAR_008557</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Alberta</strain>
            <tissue evidence="26">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001765">
        <property type="protein sequence ID" value="OXU22976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX67"/>
    <dbReference type="STRING" id="543379.A0A232EX67"/>
    <dbReference type="OrthoDB" id="63265at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07832">
        <property type="entry name" value="STKc_CCRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000579">
        <property type="entry name" value="cyclin-dependent kinase 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048002">
        <property type="entry name" value="CDK20-like_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF171">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 23 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 23 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OXU22976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="334" mass="38000" checksum="FB8CFCD10224C220" modified="2017-10-25" version="1">MNRYTISGRIGEGAHGLVLKAYDNASPVPKPVALKRILLKRIEDGIPTSVVREVKTLQRLKHPYIVELLDAFPAGLDFVMVFEYMPSGLWELLKDHDKALTDSQIKTYTRMLLEGVAYMHANNIMHRDLKPANLLIREDGVLTIADFGLGRLMWEDISRPYSHQVATRWYRAPELLYGARFYTAAVDMWAVGCIIGEMLNNSPLFPGESDIEQLAIVLGHLGSPTAESWPELSSLPDYNKITFPYHKGVLWERIVPDAQQEAVDLVRNILIYDSSKRLTAEEALRHVYFNTKPYPCTKAELVKPPTDHRTRLKPKEIETNVKASTLFRNMLSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYD5</accession>
    <name>A0A232EYD5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001698">
        <property type="protein sequence ID" value="OXU23188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYD5"/>
    <dbReference type="STRING" id="543379.A0A232EYD5"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19049" checksum="419B55B2DE923802" modified="2017-10-25" version="1" fragment="single">ESLHTSLLRLIGNCAFCLLRKADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYK4</accession>
    <name>A0A232EYK4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001609">
        <property type="protein sequence ID" value="OXU23441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYK4"/>
    <dbReference type="STRING" id="543379.A0A232EYK4"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15669" checksum="D7FF0F5C4C0A04D9" modified="2017-10-25" version="1">MAGGKTAQSGFQPDSDVHISFEDQQKINKFARQNAKMEDLKEELKLKQNELQNLKDAVSELDLFDDDAKIPYHIGEIFVDQDLSKTLSCLEDARVKKEKEIVSLEEQCTTLKSMMTELKTQLYAKFGNHINLEADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZE0</accession>
    <name>A0A232EZE0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001515">
        <property type="protein sequence ID" value="OXU23735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZE0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="7454" checksum="927A2D729F0BC87A" modified="2017-10-25" version="1">MDNSGVEIVDSDPEPMDQDDDSSCSSSRISSDSEADKPYKGSGTRSPLAPASRLPQTPMAVSRPTNILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZR0</accession>
    <name>A0A232EZR0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001464">
        <property type="protein sequence ID" value="OXU23882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZR0"/>
    <dbReference type="SMR" id="A0A232EZR0"/>
    <dbReference type="STRING" id="543379.A0A232EZR0"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22016">
        <property type="entry name" value="HMG-box_NHP10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="208" mass="24490" checksum="1F2868114F470E82" modified="2017-10-25" version="1">MSDDSDYDAEQEEIDVYKRKYQLLAERCEVLQQDNERLVHRIQQARKLLKRTKKEKKYLINRLDQHGDNWREAPMGVLEENSIFQSTPKQEKGSKSVVNNIKEEKPKKGTKRKAGKADPNAPKRPANPFFQFCQEQRPRVMERLAGDPEPSKQELTRQLATTWKSLSSEDKKVYYDMYERSKEKYVAEMQIYNKKAEDAPPQMSMNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F061</accession>
    <name>A0A232F061_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001450">
        <property type="protein sequence ID" value="OXU23943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F061"/>
    <dbReference type="STRING" id="543379.A0A232F061"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26933" checksum="ED575448BE536E0B" modified="2017-10-25" version="1">MYRWAGKVAVIAGASSGIGLATAKALVNHGLIVVGLARRKSKMESDMKDAKGNGRFYPLECDISNEKQIGEAFAWVKKNLNSVHILINSAGIQRAGKVTDLSFSELKQIVDINFIGLLYCSKVATTIMKEGGEESHIIMINSVVGHRLSQIPSEHSTNIYAATKFAVRALANILEKESYGGNIRVTNISPGAVKTEMTDKIAEDIPQINQLDFLNPEDIVDAIVYILGTPPRVQIEELVIKPLKAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0I0</accession>
    <name>A0A232F0I0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001427">
        <property type="protein sequence ID" value="OXU24007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0I0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="281" mass="32116" checksum="DDD7C541DB411325" modified="2017-10-25" version="1">MQCPAVRIHSGVIILPPQKCTIHSKNSGIITIHSRNSGGVTTHIRNNVVRTDGRRVRVAEKIDDEATQDLPLQHITPSNDPRQRLSFSLAAEGQTPASGTLRLRDGFLPERFFCDRRESKEIPAESKRARGNPLKYFLCSKEEKHRMKFLIILCLTTIGVVLVEGKTEHPVESELLEKIVECYQREKCHERAKASLSNYAARHVERDDVTPMRWSFLEFETHCQSTKEMFTQAYAEFPTEKINYEYLTRVQGSNFNYEKELSNHPAKISRAENTTSPQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F263</accession>
    <name>A0A232F263_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_004516</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001191">
        <property type="protein sequence ID" value="OXU24791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F263"/>
    <dbReference type="STRING" id="543379.A0A232F263"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0492">Microsome</keyword>
    <keyword evidence="13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="17">
        <location>
            <begin position="597"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU24791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="888" mass="99105" checksum="A77AEFFC5C13E3FF" modified="2017-10-25" version="1">MLSLIKDCLWEPLPIVLIMLGYALYAFLTSTFDYWLVRGVPYRKPTPLLGNFGDLLLFRKSQPEGISEMYNWFGNERFFGVFRVRSPILIVRDPELIKCVCVKDFHVFCNRGIPVNSTKDPLSGHLFNLEGKHWKSLRSKLTPAFSSGKLKNMFYLLVECSDDLTRLVERRLEVLENSSSSSSSSSSFPDASIVEVRELAANFTIDVIGSCAFGIHINALSDEDSEFRKAAGRLSKPSYKATLWRMLRTSMPKLYKLLGVQVIDPSVTKFFMDVVSQMVKERENKALKRHDFMDLLIELKNRGTLELDNGNGLRAHNDEEVPVAEEIVLDENTIAAQAFVFFVAGYETSSNTIAFCLYELAVNPEIQEKARRDIIDALDKRDGKLTYDAVQDMKYLDMVILETLRKYPPAPLLSRRCEYPYKLPGSDVELSKGMRVVIPIYAIHHDPKHYPEPDKFRPERFGDEEKRARHPYTFLPFGEGPRNCIGTRFALLQTKVGVITFLRKYQVEVCEKTDIPIKFSRRSLVTASETGVNSGIMYLSATTLSVKEIFANFEHPVVMAFGNPLLDVILTDDENNLLSKYNLKIDGQTELEEKVMEQLFADLPEGSKRKTSAGGCAQNTMRVLQKLCGKKNGPKICVYYGGLGKDSRGDMLEELVRSANVDARYAIHPTLPTGVCVSIINDGYRSLAATLGAASIYTLEDLKTTVLPLDTVRVIYIEGFFVTHSLDVAKEVVRRAQGKNIVIALNLNGTYIFEDHHAALCEMVGLAKIVFGNVEEMKALANSLNLKFDNPTDIPFLLNNLKGVSVNASNSSSVWGQGQSAQISPIKPKSPVIDTTGAGDSLVAGFLAGLLTKKDPKTCLEWGCKVASEVVTNIGATLSNDLPADFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2D2</accession>
    <name>A0A232F2D2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001206">
        <property type="protein sequence ID" value="OXU24742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2D2"/>
    <dbReference type="STRING" id="543379.A0A232F2D2"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="325" mass="37009" checksum="5C9DC77B8E60C86D" modified="2017-10-25" version="1">MSCNTCQAKFSFFTKEVGCANCGFSYCTKCLKYKVQLPVVGEKKICGRCYNKMQTIAEPVTATEDFSIPDGLDEPLAPIDITKKMESLENPARPPITMYRQGSKLDRLQVGLDPIDQEIVNRLKKLKDEDKQLPPPTEDEIRRRLALLQDQDPDIANQPINIHQVDTRTDQEKTDDLIKEYLEILEIGKASGEIDTDIQARLDNLRGIDSSKYKNYITDFEEDDDETATMKVIQKALAEATLEAKYCDVDELVDIETEQPAQRSKNTHHDDYVDTCVLCDQTANLVMCKGCTGDLFCPVCFEDNHDDFEMHKHTTVPFKPRKYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2J2</accession>
    <name>A0A232F2J2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001167">
        <property type="protein sequence ID" value="OXU24915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2J2"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263212" description="VWFA domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="49231" checksum="6767C52E4DF2C94D" modified="2017-10-25" version="1" fragment="single">MQCSLLLKYQITCVFVLILYQQKLHCCAHWINHILDKITEEINPHQVTVFTSKSNSYPATQYDVVQRNIVRRFSTMSIDSTTKVEYLGDNRSWNVPVHKNPREARVLYVVLQNVKNGSVDVDILKELFRNFVNFAPIPQRPKCLVIIFGFNGTSEKSMRSIYSVLQFAWEKNFLDVTILMVGEYDLPKKIVYNPFTNAISNGIFNNESELFPQKLNDMNNYLIKLPLYKNGNPYISYHKNNNNKIIAEGCDLDYIVTFSKIINFNITYKVFYPATVDDKYKIYRKLRTNEINTIHIGMMVGTMLPSICVVYLSYGKHAIRKPQMTNGVPILKMTKLMLNNDNIAFPFERGSPYLEKFNFYLRKIVESGIPKLWTKRREYKAEGMINRTVDHSTKESQMEVEITLLIIGHLIAMVLFATEFIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3E6</accession>
    <name>A0A232F3E6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_007618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001084">
        <property type="protein sequence ID" value="OXU25205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3E6"/>
    <dbReference type="STRING" id="543379.A0A232F3E6"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016820">
        <property type="entry name" value="Mediator_Med6_met/pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023869">
        <property type="entry name" value="Mediator_MED6_meta/pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR023869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="229" mass="26241" checksum="6A11C94CDD75D753" modified="2017-10-25" version="1">MIPGRLPVPENPLGLSWHDSAWIPMLNPSNIMDYFSERSNPFYDRTCNNEVVKMQRLNPEQLMNMTGFEYILLHVQEPILYVIRKQHRHGPTQATPVADYYIIAGVVYQAPDLASVVNSRLLSAVHHLQSAFEETSACSRYHPSKGYSWDLKNGKTAAAKKEIPVREEPSTLFQRQRVDMLLGELTRKYPLPVPRPVQAVTEPTVQIKQENQTEKQGMKPPPERKPRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3I9</accession>
    <name>A0A232F3I9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001146">
        <property type="protein sequence ID" value="OXU24987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3I9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="154" mass="17831" checksum="388EAE48AFAEE6BA" modified="2017-10-25" version="1">MISNTNHINHACRSDNSVHKTTTQGHVYNRRWVSDKRKHSSLKPETVMEYTDFMHIMGISSQYIVTLGSIKLSIMGKEHFFHILPDETPLSEHLILGNPFTYHEKVNIMFEDEVLMTESQSILSSIIVPFVHKVFLMNEIDPDEIGLKLLRHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3N4</accession>
    <name>A0A232F3N4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Equilibrative nucleoside transporter 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001061">
        <property type="protein sequence ID" value="OXU25295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3N4"/>
    <dbReference type="STRING" id="543379.A0A232F3N4"/>
    <dbReference type="OrthoDB" id="10014563at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="72421" checksum="25DF94796C033F5E" modified="2017-10-25" version="1">MDENLSRGYVQLGKARRMNEFKFNENGFARLSPPVDKYNLIYLSLILAGAGFLLPYNSFIIAVDYFQARYPGTTVIFDMSVVYITMAFFAVLVNNVLVETLSLGTRITFGYLVSFLTLNFIVICEIWWEVVGVATSYTINLVAVAIVSLGCTVQQSSFYGYTSMLPSRYTQAVMAGESAAGFSVSINRILTKSLIEDERGNTSLFFVVSIITIVVCFVVQQIIYKTEFVQYYISMCQERNKITLEPQEDAGLVRMDPLDQGNDPSRGQYGVLKLQTSPLGPDSAGGSVDMGNTTGQFFEFSFSNPVYDPTAPSGNPPGSAGPTYKVEDIVVMRGSYGNTQSTTSKRWSGIKRGLVARMEVAKLIYPYMASIGMAYFVTLCLYPGIISEIISCRFGSWMPVILMTCFNGADLIGKMLATLLCQWTRTQLMHFSCARTLLILLFLMCAMPRLSPVLSNELFPVILSIVLGITNGIVGSVPMVQAPTKVAEEYRELAGNIMTLSYTTGLIFGSILAYMLDACLGPPVTAKQICPKPTIYPVVAITPMSISNVTMNLLTTAATTLASTTSSTPIPTTIPTTTTTTTTLASTIAMIVKATKKAGNATRRATKIPKIRTTASTLATVFPWAVMTSTASEAVFRTEMMNATSTAIPNLLANATAAIGNGIFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4T9</accession>
    <name>A0A232F4T9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001009">
        <property type="protein sequence ID" value="OXU25498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4T9"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041506">
        <property type="entry name" value="DUF5645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18713">
        <property type="entry name" value="DUF5645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="291" mass="34536" checksum="FE237C6FE8A2DD20" modified="2017-10-25" version="1">MMDTLQILPMEDWPLLRDTLKRDWPMYAYHYNWVKTAIKWRKKEPELEHEIYCPNGKYDSGVFVGISNSGFFVTTVFAFKESKDVLKRAINETKIIKWDKGVLFNSVHEHFVDVVEEFLDKIKKRKNIQIIKDMTNYFFKSREDCAKQELPKIPEECEIKHLNLSDIRLIHSIWPHRDLERPETSKKYLENFIRLNRGVGLFLKKNDRLVSWVLYGELGHLGMLQTVDEHKRKGYGKIVTQVLSKELADEEGLDSVLFVVHKNVASEKLFESLNYKRVATTFWFRTEPFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F515</accession>
    <name>A0A232F515_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_011089</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000922">
        <property type="protein sequence ID" value="OXU25894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F515"/>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="345"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="448"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="557"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1011"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="1185"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1378"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1408"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU25894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1432" mass="162995" checksum="12F4806BC23DDF78" modified="2017-10-25" version="1">MSFRSATALTCITRKPLPIFQAFIDSFFKKLTYACLRMAFTFIHVESLQNIYTCSLCTRTFAICVGYPDDPYHVGRRRSKRLGIPDSAYHAMLLSESEDRFATEAYPSRIRGSLDEIHCTRLYTYCVLEHRDTHTFLCFSVAEFELNDRMIPRKRLQVLLYILQIFYVFGDGDPGSDGLLLKDLPNNVIDEPAFTSSTTTTTTTTTTTTTPVLIDHDDKSLNSSQKIYNSSEKEEDSVDTRENVVVTDKPDLSNSNRITYVEGLEVARGPTFLNVSWISSGADGYEIKVWTEEEFLDTYWSKKSEYSITGLEPCREYRIGVTPMPTNENDAEFINTTTEFEEPGPVGNVNLTLQEPFSLVVRWDMPENANRCIQEYKIIADTVDDYNRHTVTNYTTETNFVFENLRSCFKYWVSVSVIDITNNTASTTNPIESLLPIYPKVASAPWLNISDVRTINTTKESITLIWDVKNNEDNCTLNEVISTCHYNYTTGGGISVIANGTAKIVITDRLIQNVTTTIKNLSPYSHYVCTAYSINEKGDSLLSKPVYVVTSEDRPSTPQNFQTLGTENSKRWFIWDPPKYTPGKLLGYRINFTWVPCSPVPDGCTLKREFIVDNIDPTLTKYSLIKEEAYSQYTARIEAKTGGGKSPSVDIKFYSKAQGVPDKVTNLTIAIKRRDDDPNALDTQLSWGLPCSLQGILHRFNVSVYGTRPGLENHTITTEVNVTDDFDKNEIFVLDLGELKPLYTYKFEVFAKVSGLTDSGEIADLEYKYPAGIPPQPEMEYIKSITLDPHKARRTTTSAAILLPLFPDVNGDIKYYAIMVSGVPFDNSSSSGRFDIQAERWPNVSSWEEAMEKDFQIPYQATEPLWNPFPSFVVDYGHMKAVKFVVGEDTTCPDVSSNTKTRAYCNGPLKSDTWYEVRMRAFTDQGYADSVSFTIKTNAELNVGLVLGVVFGILFIGILTTLMLLVKRCSFRLLLQRILQSNIPESPVPDPFTRRKFINHCQQLAENPGKLSNEFQLLQTLSVDLQMPSNAACLQANRKKNRYSDILPYDFSRVKLEVIDNDPNTDYINASFIRGYSGNEEYIACQGPKEDTTYDFWRMIDQYDVKMILMLTQLVEKGKEKCHQYYPTIRETFNYEKLSIRCTSELDYRNFTQRTLVLQKDDKRRTITHLHFKDWPDHDVPDDFDAMIHFCQIFRKQFSTVKGLAVIHCSAGIGRTGTLIAIDILLQSIRDNRKLDVFGTVYRLRRHRLNMVQRESQYAYIYNCIRQVLKNPYFLKTYKPPPIDPIYSKDKTKKDRSDSNTDLVDSFDTLKKNSLSTSIDSMQPLCQSSPQTTPKIQMNGLRYCKSTSAIDTRTNHNRIGRYNSEGYAICESARDSFSTTSKESTDENNDLKSSSSSLYENVEPLIRPSSSQTIAGSSYYLTNDSGEKDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5W5</accession>
    <name>A0A232F5W5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000895">
        <property type="protein sequence ID" value="OXU26035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5W5"/>
    <dbReference type="STRING" id="543379.A0A232F5W5"/>
    <dbReference type="OrthoDB" id="10036121at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000043">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="13600" checksum="39F8D896A52C240B" modified="2017-10-25" version="1">MARKAAAKKFLKSKAEKIATPPPGSVPVEKKKGKGKRKREFLVLKQVHPDAGISSKSMSIMNSFVNDIFEHIATEASHLISLNKRSTITSRDIQTAVRLLLPGELAKHSVSEDTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6Q1</accession>
    <name>A0A232F6Q1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_005247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000779">
        <property type="protein sequence ID" value="OXU26546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6Q1"/>
    <dbReference type="STRING" id="543379.A0A232F6Q1"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="272" mass="30124" checksum="F1ED7E63C24EE6E7" modified="2017-10-25" version="1">MPRARRRHRWQHEAGPAELQCYGGFCGTVLRYQVNPPESSSQLRMAEKKDLSEVRLAKYVQYALSRGFSVSIIKELYKEPDNPVTATTVKTQLLIAVRKLLGTEGAAHKVDILKAIMSIVRKEGKDTIIFATKEDHATPSKVTLPAPEPSPGLILPNGEINWNCPCLGGMATGPCGVEFREAFSCFHYSTADPKGSDCYEAFKTMQGCMSNYPALYANKGTDMDDLDNESGELENKSEDRRDLKEDEVPEVRNESSQSVTSSKTEVEPAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6Z1</accession>
    <name>A0A232F6Z1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000842">
        <property type="protein sequence ID" value="OXU26240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6Z1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="11478" checksum="37B137340666BE6C" modified="2017-10-25" version="1">MLHSEPDGGRILSVMKEPLDTGISAIMLSKFTPYANEFDIIIQRSLESGIPIFWMSNAIRIYGLTRRGENESRVYLQGLREEKPFTFKESIKEMPLAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F710</accession>
    <name>A0A232F710_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_000506</name>
        <name evidence="17" type="ORF">TSAR_005849</name>
        <name evidence="16" type="ORF">TSAR_007162</name>
        <name evidence="15" type="ORF">TSAR_008314</name>
        <name evidence="14" type="ORF">TSAR_013416</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002259">
        <property type="protein sequence ID" value="OXU21709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01000810">
        <property type="protein sequence ID" value="OXU26382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01000442">
        <property type="protein sequence ID" value="OXU28357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01000238">
        <property type="protein sequence ID" value="OXU29800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01000061">
        <property type="protein sequence ID" value="OXU31398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F710"/>
    <dbReference type="SMR" id="A0A232F710"/>
    <dbReference type="STRING" id="543379.A0A232F710"/>
    <dbReference type="OrthoDB" id="8112831at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU26382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU28357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU29800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU31398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="136" mass="15388" checksum="6FD8508EA50A0EEC" modified="2017-10-25" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F752</accession>
    <name>A0A232F752_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylethanolamine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000752">
        <property type="protein sequence ID" value="OXU26686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F752"/>
    <dbReference type="STRING" id="543379.A0A232F752"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013302845" description="Phosphatidylethanolamine-binding protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22646" checksum="382903B8D46417D1" modified="2017-10-25" version="1">MKLLTAGLFVLAWSFAAADVASELKAAKIDPELIDNAPNETIEIKYGDKEVKLGNEFTPSETKEIPEVHYKHEGGVLYTLVMTDPDVPVRGYNREWQHWVVGNIPEDKVAKGEVLTEYVAPAPSKTTGLHRFVFLLYKQNQGSITFDERRIGNRDKRRNRFSTKKFAEKYNLEGPIAGNYMKAKYDDYVPTVMKQLGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7L6</accession>
    <name>A0A232F7L6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000754">
        <property type="protein sequence ID" value="OXU26665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7L6"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="568" mass="65763" checksum="46FCB3606858DEC6" modified="2017-10-25" version="1">MKKYRVEAFIIPTNGNKEVDSNQIDDVKLAKKLKDHSISSSDETIDERNNGKIEENLNNRSNICTEVNDQSSLELSGIFFEINEHIYDEIILPEKKQETQVIPNKKTDTEYTKTIFRVEEPLYDEPFIGNFTKLNTQQKDQDHSKLSPWVLGNSKYRRFGIVAPKLPRRSSSLKSIVEDIEQFDETLQEICCHGRINGCLLDHQRPEDISEDIFKENWMQRLDSLRKLETLLKDKEVALQSRERLLFKKEKELRILERLVKDKMKQAELYAKRYKKSLSSESIPSNNRDLESRSSNGSKGHGTKSEEFLSVTNLPSNTNSKTSLESKERTFKNPPNSRSSLTTDRLSNRIGSIRSRSRPKIRYEDLDSTLSADIGDSSFVVTSRKFDPETFKKPAAFIRSASERRPKVEQQINTLRLSCVTEKDERGDDLAEVIEEKTLKKISENILASQNHETKFLNYGLIDEKSSVNVDIVDKKDTVNQKRFSYLNLESISKAKSKIVSKERPVSWSEDTDDWLKKKRLAYNMATNKTLFESTAEKENLSVQTKINKSVKMNKKKENTRKKFSIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7M5</accession>
    <name>A0A232F7M5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_012573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000752">
        <property type="protein sequence ID" value="OXU26675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F7M5"/>
    <dbReference type="OrthoDB" id="8197317at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="2311"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="2311"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1374"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1620"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2258"/>
            <end position="2292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1725"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="911"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="958"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1380"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1397"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1620"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1642"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2258"/>
            <end position="2271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2383" mass="263668" checksum="E294B664B9AB2BAF" modified="2017-10-25" version="1">MASDFSSGCTEVNDILDDEKEEGEISLEDVSSSEEGPTCKYLPRAFGQCRYCLSTHQCATWCSSLTVNKINMKREAPCRIVAQDAGLQGKENRSNRRYHKDGLQVPILGNSSSSKSIPYSSSTLQEKNDDDPIGPIINNDLIPISSDSDMEVVGLTSEKHEKKSSHRRKLRKKRRKKSPDTLSLSLSPNPQDFELFSTHRIERDKLESGHPKYRHHHSPSRRKLASRLSSPPRRRNRSPLANRSDRRRTRSPLKTSPSRSRKTVQKKSRMIENDSPVKQSFNKLLKKVRHLETCSRSREKGSSLQDKLNNIIKQDKKESSAPVEKSKEPSHEATLSEEPKPAVKDKAEEKEDITKKPIVLEEKNDNDNNNKEEDEEDLVILRQIALETKVKKSVALIKPEDIKTEPVDEPSAPAPPPPEEPLPQEPPPPLPSPKLSEPAQPEQPQQPQQPQQSQQKAEDKAEHKLPNFCMDDNDEDLELRMIALHSAVLKKHRTRIARGRRKRLEATVPRIESPFTSSFLEDFPMLAEICSPTSPLGSKRDILLAEDMELDSDMELETLLSEPEDQSPYSPSDDITGDMLLDRDIVQPVPVPPVAVQPIGKNRSLYSPSNPTETAASAIQQTTKQPEVSRLDGSILEFTSQESRPYSPSDATVYDPDLPGLHSPVKSTTLATTTPTGLASMPLQPPPMPPLSMFGPQQPMLLGCPPSMLNAFGDPIAMAPSSMVTGFPALHQSVNPLLLPTAPPLFAYPTAHPAAVSIPAPQPAIPFKPESNELDDFMETDLDGSPLVPIEKDGNEQRWQLLGEPLYLQNVPELTQSEHSKLPTLMERSLVPAAVLRCNKQLQKQPPKKPMPPVGEALFRNADMRPVALVEETDVRAASFKPIKLQAQPKKSVIAQPAAAFNSTLDDIVAKEEKPSKSTKEVEEKKEESRTSPRKKEAIETADSKCKSKKPASKHKSKELDSSRQSMREMLNERRKDLSRRVRERSCRLSRARSVSKNISKTKKIEETTKKEISKSDDKKRRSSVEDDEQALRESLLASLAMKAKEPQPAAVPKPSVPEKSPATRKPSAESVPKSTDEMPLAERVSAFLAKSKEKDLKNGTAPVSATVSTATGTNQLKRVSEPLSETLLPPRKIIKRVASMTPASKVVNNAKRYQNLMLQRKLTQQTGSPAIKSRFKLNHTSHARSDSPVVTKSSNEIHRIIINLNEDTESESEAEEARSKVSPVKVRPTLNIPTTDFEKSVDQFLKNARQQQEMASTVNKNVVSAKPVKNNPLPMGPPPISTPSASKAVTDNTNVTTAKVTVATPPVNESIGSIVSTTADSVSIAKNKVVPPKVTKTTSKLLSNATATPTAVKHLTLAQQEEYRLLKQIIQEREKTKESTSTTAQSQSPLEKITTAPSSSPLSASSSPPSVLTICTSSALSSSTPKAVAKVVLSPTTSIASSLSVKPHEQVLRQNEPVPKKQSVATISPISKPSVESVKVPLASNKPLKIGVSSTKIIHVSPSISQSNTLNKTAAVITTTSTSKASAVAGTESTATTLKLTPQSNNNMLLGMISDSINRQRQQISDAAQKVSTLTILTKEQINLKTSQIQQTKLNSEGNVVMDDLNKIGNNLSITSKRFTGETNKAQSTKNIENVNTKSALKNDPRKDSSSVDTSQDKTRQNWENFKEVVNDEVQALSHLPAQQQKELLSKTEESLIEKRRSVVDDIAEMSLKLREWEIERDLQYKYNEEAKKLREELRKVEGKIQQQKDKLNTIQPQVSLYHKKINSGRKECFKLSKICDSLGQKIIGSNYNVPTAGAEILNNRIKEVVKHTQKLQNKKTQYTNTVQNNFGKTGNTSGKKNFKPNNNNLFKRKEIVKQLSLNNNKIGVLSSNSTNINSASKNEPSSTVSNNLNTCTNEKIIINPKIKNDPIDTSTENSNANTKCTVANNNPFTSTELTNSVLNLNDTSNLKTITNSNIPNIILTADSIANLKTENLSVNLNSDNEIKKLNQTFEDKIDKQLRDNENIILSESTDNAGSSTKNNFIKANLTMYSPKSESITNVNSPNDFDDSRSIIQRGVENSASNAASSENENLPTGINVIQTISNVENTESTNTENQTLQTVSIKNNIIKTETEEIAPESIEVLTTVEENRSVETYNPNLSTSNAPSEKLNNETAIQKMALDSDNAITDSDTQISFCTNNVDNNINIDDDEPMETNNKIDEIKIKLEVEDHTSSTSEIHNNIDNSLSSMSLIHVPKIEESVLPRKKSRLFKSAIKRKPTKAQQRKMYNKQKQQLKAAENFAKGSEDSKKKSIQPYESVLKPLRAPRNYTNGFLCPFEMQGTCNDGDCKYIHSYSASSSESLRDMQKSVAGRIIFSSFLKIAPEVDYLRCEKNAVMTSINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Z1</accession>
    <name>A0A232F7Z1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000730">
        <property type="protein sequence ID" value="OXU26775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Z1"/>
    <dbReference type="STRING" id="543379.A0A232F7Z1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="181" mass="21041" checksum="A3018A90196E74D4" modified="2017-10-25" version="1" fragment="single">LDGGRISRDPATPVLPLFDKKTWAFFSYVSALAGTPTGCNASSFLLQRGRKLSLFITSAVSILGWLVIYLSKTYKNFYGSCFGSRNWLFCRNYFTRNTMHNFDMDKHGYSCSILAVYIFEYTFPFNGLPEDHLLSFDLKDQIKPKVLKRLKRNTSFEELRCRKAMKPFLIMLCFFFFQQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8C2</accession>
    <name>A0A232F8C2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_015798</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000710">
        <property type="protein sequence ID" value="OXU26852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8C2"/>
    <dbReference type="OrthoDB" id="10039931at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="772"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="861"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1003"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1081"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1118"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1164"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1205"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1337"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1367"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="587"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU26852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1477" mass="167525" checksum="539E68689487DC02" modified="2017-10-25" version="1">MLLGDSGVGKTCILTRFRDGQFLSGNYITTVGIDFRVILFTLFTIHVVLNVGIADFRLQLSLNNNKMVTVDDSQVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKQSYDNIRAWLGEIREYAQDDVVIMLLGNKCDCGSERIVRREDGQRLANEYKVPFMETSAKTGLNVELAFHAVASGIVFLLWPNAALAGFKVSSNDKLPTLVCTTCIKNINHWHSYKDTCLRSQEKLQQWMMSKQNTAAVPMVTIKEEPMDEAAPNNAQNESSATNHTVQNGMDVDSETNATLTTGPELEKSSKISEMDRAMIPEIQIKTEPLDTEDEDDCNVDVESVNSGELLINPMAVAANNVNTDRIMEADSTQKFGSRRFATRKKYRRGPHTHFRGAKLFKKKCVHCKIYLHSKHSFIQHMSRYHGIVNSLGSNETVKVVNQPSVNKQKSKLSEHPDNVELLAEIQQESNPEDAEFEQMVKTDPLTPVQKNIIGQLKTFSCYSCKQTFFDRRHTLNHIRQHMPDLRPYTCIACLTEFSDRSMYKLHCGASFECAMKIALVVPKGGNEKYFTCNMCLRPFANRSELLTHLAMHADKQHKQQAQQPVRSPPKSNPIASPLLAPTPESSPSKRSITNKIAGPYMNGDPAHNHTCDLCGMIYRYKPNMFKHRELCSSLAENIRTSYRCAHCSMTYLVYKKFYSHVFSDHKKREITCFTCHEKFPTADEYLTHHETHRVFSKDKENANEVASEQQQQQQENDSSKSSDTKASEDPLNASEKPFNCALCSERFATKLELTEHRNLHLKVKIYSCVICRSMFSSSGALEIHMKEHGIDDAVEQNANSSCIEYNSQSSMNESSMSATSDPGGKFHHCYPCGKNFSNYANLKRHERNLHIKNMKRRWSCDFCKRRFKSSQAHDEHVLSTHGMHPSQLQRQSKTPPQVVPTPQFSAATGKPLMQCPKCPKTFTYQGNLILHCQNVHKESPYERPQSSAMRQSAPPAPRRALSIVTARGYACDICGKSFREEQSLKTHRGWHLRSNYRLKVDQNASLNERAMSSPGYTMTSAIPKPAKARKSFPNNPSQKQLSALASLQCQVCDDRFPDVEMLRKHLWDVHCARNKPEKTFTTDLQCELCTNKFPDEEELENHMKWHAQNPILGGPLNNRVPVSEVPKKTFCCDVCGKYYSNRKLFLRHKKLHKVLPASTMMNLHSLQNRRHYCHACQKSFATEASLRRHKASPCHQSAARSHMQASKKITTTALVHHPPPDPMPEIKDEPSEMDYSSLPTHGAHGQLLKKRPVTCHICNMIFPNMSVLYQHKQLAHKQSAVSSKSPAPQQKDCVPVVSSQGLVACNLCGKQFPGISNLKQHFAHKHKTKGSSFPCYAPGCKLVFSSLSSLKNHETTHSSMIFNCLLCDRHVFSRAAMTKHMLAMHKAIYQSGADKSTLWTETDLTNYTIKNCQSTACPKCKVKYPNLRALKIHYLKFHDNKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9V4</accession>
    <name>A0A232F9V4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000566">
        <property type="protein sequence ID" value="OXU27634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9V4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="45" mass="5026" checksum="FF7D11F1B5E4ADCC" modified="2017-10-25" version="1" fragment="single">VVQIGRVLRLRIEKQPLRKRLTAITEIISRGQPIETGVGVMSPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA59</accession>
    <name>A0A232FA59_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000647">
        <property type="protein sequence ID" value="OXU27197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA59"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14368" checksum="B318BFEB77926795" modified="2017-10-25" version="1" fragment="single">TINKNFVNVDGNESSSAIRGFLRSLNTNIVTATLPEKPGAQTRHNDLLRYLVPRVDSITSSPGVFWEFDRATKHGCGVILKIILKGDVDTVYPWNEVPRIPLFLLYSCSESSKTPETTLILATVGPRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBM4</accession>
    <name>A0A232FBM4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000487">
        <property type="protein sequence ID" value="OXU28055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBM4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="11769" checksum="68C5FB802EC46271" modified="2017-10-25" version="1">MGVIRSFRALQSSFPFIFQNHSFQADGRIQKLSPYSWLILYYSKLCGQKNILHLNHVMLCVYLVFLNCAFFFSIYSAGIIFYSTVWLFTRYARALTSRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBY6</accession>
    <name>A0A232FBY6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000503">
        <property type="protein sequence ID" value="OXU27968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBY6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10818" checksum="E077F4C40F8AB0A2" modified="2017-10-25" version="1" fragment="single">MRRKNQYILNRLTHNVKRLSTAVQIVPLHNIVKNLMADYEEENSICAFILVAFVQSGKKRETESVDIIPSQWLRYNPKKERCVTPFMKSPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCB5</accession>
    <name>A0A232FCB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).</text>
    </comment>
    <comment type="function">
        <text evidence="11">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
            <location evidence="2 11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000428">
        <property type="protein sequence ID" value="OXU28471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCB5"/>
    <dbReference type="STRING" id="543379.A0A232FCB5"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="181" mass="20468" checksum="A81CF29C6B460F0B" modified="2017-10-25" version="1">MPVSKAYHSSFMGTKNSLGNMALLPLKTTFRGPAPPLANGEEMDIIDEALYFFKANVFFRTYEIKSESDRVLIYVTLYITECLKKLQKCINQHQAQNEMYSLAISKFDIPGDAGFPLNSVYAKPNSPTEADAMRQYLLQIRQETGSRLIEKVYGADGKPSKWWLCFAKKKFMDKSLSGPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCN5</accession>
    <name>A0A232FCN5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000432">
        <property type="protein sequence ID" value="OXU28435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCN5"/>
    <dbReference type="STRING" id="543379.A0A232FCN5"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="212"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="34146" checksum="47B37042439BD931" modified="2017-10-25" version="1">MVLKRFNMLNLVAKAQGRMSTEMGADRYNMENPNRGKYVVFNHETFATQLAPRKGSSVDTRKIKQTFQQLGFTVDICNDYEYSGIIKKLEELRRYDHSDNDCLCIFVLTHGVMDDFISAKDTNYKLDKIWKPFTADECSTLAGKPKLFFFQTCRGTNLDPGVQMISFSGTTQTDGSGSNTSYRISTHADFFIRLQYGSRQKFHSILTPLFAGFYSWRNPTEGSWYVQSLCDVLDKYAATRDLVNMLTITNRNVVENFESYNNDMPLLHNKKQMSSFTSNLMRDIYFTPKNQRNTTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDC4</accession>
    <name>A0A232FDC4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_015411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000397">
        <property type="protein sequence ID" value="OXU28675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDC4"/>
    <dbReference type="STRING" id="543379.A0A232FDC4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0114">cAMP</keyword>
    <keyword evidence="2" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10465" checksum="FBC54AD90EE6FAD4" modified="2017-10-25" version="1">MSLWLTEFYPAGAQIVRQGEKGNKFYIISGGTVRVTKDTDFGEEELVVLCKGQYFGEKALYDDSGENRRHANVIALDPVECLTLDRTCVFLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDZ6</accession>
    <name>A0A232FDZ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000347">
        <property type="protein sequence ID" value="OXU29014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDZ6"/>
    <dbReference type="STRING" id="543379.A0A232FDZ6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21636" checksum="703EDF5654CF1A3B" modified="2017-10-25" version="1">MELTSIKIGLSVTRVLVPHIILSKYRTILSSLRRKNVPLKKVNSKYILKSTLTPRLARKQFQKNTTGIERSRSWSSLDNGNVSEKDYTSQNYLTIHSFPSTINVPAVRIDDEKDYSIGSVVTIDSNPSPPPPAPPVAKPFQRRGTLARLNTFTTMTPQQIAQWIDKRCRIVFPVSFLIFNILYWSFIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE73</accession>
    <name>A0A232FE73_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_015024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000349">
        <property type="protein sequence ID" value="OXU28995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FE73"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="388"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="706"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="915"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1086"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1164"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1268"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1164"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1278"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU28995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1321" mass="151512" checksum="DCF12A4006B16BCD" modified="2017-10-25" version="1">MRNLVIESQWTNTFNDGDFLPHEKYHCCYNADKDRYYIIEGEDNRFLAIDASNNRKYIDEEVIFNNKELKPIGIEYCSINQEVYVACDCGLVICMTYLDDEKVKYEEIADFTNGLQCMKISPDHEVVVLITKDNVVITLSSNFDILQEVNLTSKEFGEKQFITVGWGKKETQFHGSEGKAAAKAKSAVIGKTDTDNGLPRITWKGDGTLFAVSYIDEEANARRFKVFDREGILQYTSELVDCLEGTLSWKPSGNLIASTRKLPNKHTVALFEKNGLLHREFTLPLETKNVQIEDLVWSRDSDILAVWYKDIASGIMTVQLWGEKNYHWYLKQTITYPKNNPVLYLAWSPQVNKDLLILSSKNSTIYTFYWTVTHSHGKDLADKAVVSVIDGNKVLVTGFRDGIVPPPMAQQTIQFDEPVNAISFAPKQIQDSEISSNDFLVLLSNNKIEFCQNINESWAVQYAKKKLYNVDLRLKDAKKYSFHLLQHLFWYKPNIVLCSVSLGVKSSLCEIHLLDVEGVEEITVDAKIIQEMPGQIEHIVPSSDSKTVYIVVNNKIYSYNDRDGLSKSDLVIMNESSTRAMVKVEFVMFGEKEAIVTLSRKYVLYVNGKQVSNNITSFFVHSEFLLLTTLQHALICFKLDENGLDQLCTRDLTIQPWENEANVVHRKQELSIRRLERGSTLVMAIPKDARAILQMPRGNLECIQPRALSLAIIGNFIDKLDYHKAFDLMRKQRIDLNLLYDHNPQSFIEHAEKFVQDVKNANWLSLFLTDLKDEDVTRTTYASSYENRSKQPEESVSGKVEAVCEVLRKIMEQNSNDFVQPILISLVKNQKKVGLENALKKIKQLKAQENVNQQGFSAEEALKYLLYMVDVNVLYDIALGMYDFELVMLVAQKSQKDPKEYISYLNTLNGLEENYRKFSIDSYLKRYNSALTHIAKIPDRFDECMYFIQCHELYSQGLKLYNSKSSEFKQITVAYGKHLSSKAKYREAGIMFTKGKDYVEALNAFKQANSWQDAIVTAMKLNLSFPQLTELYEELVSRLLEDKRYEAAAVILSKHLNRYEDAVATLCEGRHWHQAWTDAHCMKREDLIETHVKPGILDHAEFMLSQIRQHKQDFEKYKNRLGVVRAQAAARELAMRNLFDVDDEPTGNERGDFSDLISDTTSIAGSTMSRSSQASRSTGRSYRSSKNRRKHERKLQSIKEGSVYEDLALIRTLHQLVSQAYKQRDEVRSIAEMLLFINSDQLAAELYKVMSEFLEDIYQGKREIWPPAEIKSPDSEEPSSSSTNLPSPSTIPQNLIEPRLLNPPEEQPSDWKLDAFKVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE74</accession>
    <name>A0A232FE74_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tropomodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000374">
        <property type="protein sequence ID" value="OXU28810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE74"/>
    <dbReference type="STRING" id="543379.A0A232FE74"/>
    <dbReference type="OrthoDB" id="2163268at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000099">
        <property type="entry name" value="Tropomodulin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43524" checksum="10906E67A3E191DC" modified="2017-10-25" version="1" fragment="single">QTSASKKTTTMTTAAKLYGKDLSEYDDVDVDELLAQLTPEEINILAKEVDPDDSFMPPSQRCSYECDKTPTGPLNRKKLIEHINKQALETPDIPELKPYVPGVIRGKKWVPPVRENLKEKEADEQIAIDLGDEYEQALTNASEDEIIDLAAILGFHSMMNQDQYHASLLNSGQPVGLGWDGVTKASQPKVYPMEPPNDTDVDETIKRVREDDHSLLDVNWNNIKNISDEKFFQLFEALESNTHLETLSLTNTGLTDKTAQRLSEAMEKNSTLRVLNVETNFISPPVIVKLVRALLKTKSIEEFRCSNQRSQVLGNKIEMEITQLVEQNPTLLRLGLHLEFNDARHRVAAHLQRNIDRIRKDLTLRLQFRFFNMNHRKPALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEG7</accession>
    <name>A0A232FEG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_015177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000342">
        <property type="protein sequence ID" value="OXU29062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEG7"/>
    <dbReference type="STRING" id="543379.A0A232FEG7"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU29062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="65095" checksum="DB8CF65AE2B6ADB1" modified="2017-10-25" version="1">MEKLVFGWIDYLLFGSLLGLSLLIGIYFGFFSKQDSVNEYLFGGKTMGYIPVATSILASLLSGITFLGVPTEVYFHGCQYFLTIINTIFNGLITAYVFMPVFYKLQIASIYEYLELRFSRRIRSFASTLYILSLLVYVPIVIYVPALAFSQVTGFSVHLISPALSIICITYTSMGGVKAVVWTDTIQFIFTMGGLVTVLVIGVRSVGGFLNVWKISNEGGRLDIFDFNPSPFVRNTFWGMAFGTLFTSLSHFAVGQKFIQRFLAIETQADINKAILVKTVGTVIIDVGVVFTGLLMYAKYHDCDPASAKLVQRSDQVVPYYVMDITKNIPGISGLFLAGIVSSALSTMSASINTLSGLIYDDFIEQWMSESSNKDAKAANIMKVISVIIGCISVAMIFVIEHLGTVLEMSYSIRGAVDGPLLGIFILGMCVPCVGKRGALTGACTALLFMSWIVIGSKWHILNKRIRYSTLPMTVENCPYPLNESLTETTTLPPINPEDEPMILFQTTFLFFVFFGSMITVVVGVATSFLLGESDVSKVNPEHITPAIRRFLPKKQYFEVNLDVLHQQENLLAEKDKEIDSDKKIAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEW7</accession>
    <name>A0A232FEW7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
            <ecNumber evidence="3">3.1.3.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inositol polyphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSAR_006117</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Alberta</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83420"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:43561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83416"/>
            <dbReference type="ChEBI" id="CHEBI:83419"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:43553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57627"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:77144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77155"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77156"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25018"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EC" id="3.1.3.67" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000310">
        <property type="protein sequence ID" value="OXU29306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEW7"/>
    <dbReference type="STRING" id="543379.A0A232FEW7"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000029">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="22">
        <location>
            <begin position="134"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="21">
        <location>
            <begin position="222"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="23">
        <location>
            <begin position="310"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="489"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OXU29306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="608" mass="68032" checksum="284420F5CED61D45" modified="2017-10-25" version="1">MSGCITILSFEQLKSQIGSEVANGLGSTLRPTSNRLNNKISEHISASVTPLHVCFEEPRGPELDLCDITSLRPQIEGGNSKRGSREVPCEDDTGAELLQSGASELKQTQASMANTISNMKMTNPIKGLVSKRRKRFTADGYNLDLTYIKDNLIAMGFPAEKLEGVYRNNIDEVVRFLESRHRNHYTIYNLCSERSYDHTKFKGRVATYAFDDHNPPPLELIKPFCEDMDSWLLQHDENVAVVHCKAGKGRTGVMVCCYLLHSKQFRTATEALNFYGNERTTDKKGVTIPSQRRYVDYYATLVQENLNYQPVTLILREIKLESISATNGGQGYHFVISEAKNKIFSSETYEIRKGTSTLCIPLNLGVPIKGDIRVDFYNIPKVKRKEKLFHFWFNTFLVREHVTSENDNEEPVERTTRALSCDGSAMELPMVHTKPRTGSLASLGPMPPSLILTIDKWGLDGTHKDKHHKLCNEDFKVSLIMHRVEGIIPPTVPTNEGQETDDMQIGMSGQVSPNELSEADSSECDTTGDEDGWESGESSASLVVKRHSHLHGSSHNTHSNAQHRVSIGEATKKSLPREDRDKKGGQKSNSNVSTRRSSGLFRSSTFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG85</accession>
    <name>A0A232FG85_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000240">
        <property type="protein sequence ID" value="OXU29776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG85"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="222"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="350" mass="39435" checksum="CA4B6B783CDDDD11" modified="2017-10-25" version="1">MIRPCNYGAIIYSICFVLVVSSAVDHSGEADDLKKVLSELEKVSSLLQSVNSINDRLINNLRVNATRYLRSNSPELLRKRGYTCTSGIGWHKLYLANLTWNEARKACRRDDAHLAVLNSPNEAKLQSVIRDDNMSLPTRYCIALCFGALFSIALAVEVVDNVGITTERSVFLSDFDRIMTRMESTKDRIAKVLNETRQNDVKSLHELLIGRGYQHTAEVGYHKLYSKQLSWYDALQRCRMEDAHLAIIDSSAEAVVISKLVKEKLPVVSDEKSVAYVGYHDYCANGWIDVFFKPLGNDNDYVHWKQGVPQSTAGPKCATIDGDGYLRSSRCTAERAFICETKLPNFSKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGS0</accession>
    <name>A0A232FGS0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000248">
        <property type="protein sequence ID" value="OXU29720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGS0"/>
    <dbReference type="STRING" id="543379.A0A232FGS0"/>
    <dbReference type="OrthoDB" id="5800423at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="757"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1277" mass="147181" checksum="BE00C62F7E75AFAD" modified="2017-10-25" version="1">MTNLVDPTEFYVQRRSTRRILEELEADIVKFIESDPPKPEVILLNSLYVVHDRSNNKWIRGRVISVQDGSPTIYEVLYIDYGYKESGLTLDSIKYAKPQFIIEPGLAVRCSLAEIAPIEGNEWDDEVIHRFSDMAKNSELTIHVLNVDETVYIVELIGFGNNNGMTVSFRDWLIDVKLAKPTTFYKLKVRMVHQEKYYQDIMDQFNHQYSKLQQKEDLTIKLPEYGDKVTLKENKVWRRGIITNIRHNESKVEVFLVDIGSTQLVPYNQLKRLPNRFCNWNAQVMKVSLLDIKPIDGVEWNLEATNFLKTNLEGRQVTVIPFLKTEKTFDVCMYVDRDININALLVSKSFAQSTGLRSKHEVLDKDISIPKKNRKKDKKNAKAVKGIATSASSKPKKETVQRVEESDPYKVRVSINKIISPDIIYVSDCSNRESYKMMTAEMQKFYKSKKGRVQGPLDPNWVYCVYSRKDKQFCRAQLLDTSESDPSIVKMTLVDLAEVEDIPLDEIQPLEPRFIDTPKYQFKVRLAGIEPCGGSNDWQSSSCQKLKDIIHDTGDFKYYITLIEDSGPKDPMPVELFITRKVFVGPINPERKETFSVARCLIDHGLALPIRGFNMKNEELKELAIELKKKLQFGNSLYDNTRQLSDISNTIIEEEPILDNDSDSNSTTDVQNVEDVDKEKIVDVSSESTPLPPKVVDWIEPAHIQETIFHANITYLDWDGNVYFHPDTNEYKDTLQYISDTLFKHYNSRSIKKYDYKWEVGDLCIASFHADKKWYRGRVTQVVSQQIVMVLFVDYGNIEECSVGSLKKRIILEHIPIQCTKARIVGVNPINRKWKESDLDIIHAATVSQPCRIKIVTRPPNPWKVAVWVKPSDYSTFFPLPWFLKNKTTVSNIKIDNSILYCQDDEDFQKPNCKPIQSVKTNEKMIISINGEDSSESSSDEEDSELAMSKNGSSVESVVVFGEIPDNCSLTMRENSELSPEITMRMNHFNRSTSVNNSRSPTVDSQNDSFSEEINEKVLSGNSIYLKMNGNIDIETESVKSEALMYDAKNGHMVASTPLNTTYQDIDTEFIFGPIDFSMYEITKMEISVSTMFSDKSFSGYILQTTNEELNQWIKKASELHEQINKFAEKQPILKIELEKNCIVKYKNEMWYRGHIVKQVDNESGYGVCVELVDFGNRFYVFDELSLRTTKDEWLQIPMMGIRFRLSDIKFDETKELKDLHRAVMKVIGRNHKFTAVIKNHGPILDLELYWDKDCKESIFTQMFKSGALEILNMSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHP0</accession>
    <name>A0A232FHP0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000229">
        <property type="protein sequence ID" value="OXU29857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHP0"/>
    <dbReference type="STRING" id="543379.A0A232FHP0"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="590" mass="64275" checksum="2E0977010E986E99" modified="2017-10-25" version="1" fragment="single">MPLRSRVNAATNQPKTKKNPLLPVPTNQPLRPTTTSSIATIHQLLESGNKPEEEAVAAVGVSSGACTELEAKNGVGIDEQLAANRYDDEVEHQSCPNDEESRSLLEVGLAGLTHRRFEDDHGDEQRLYLSPTSAQYPPAPAASILGEESQAQSPSEDHHQQPPQPHHRLVSRDNNIIISPSEQHHPHQSYANSSSGGGTAVELGAGELVPASAVVPEGGDSLRQRRRRRRHSDELSVPTEGKSAGSHMPLVLAMHRYGTEALSPAASSDHHSHHHHHHHHLSAGEQQVIARHLEEQQHQEQEDVDRVNGITAAMRGARGEFNLNVLFPGMSSSAGNHQHQQQQQQHLDEVLHDESAYLQIRTSSEGVSPVPVRTASSPGSSRSPHEDHQQQQQQQQQQQQQQQELSSPHRHNDSGYSPSQEQGRLQSFTHLTTMQPTVVVNHLQEVDRVQPDQLYIESIYAHQQTAAHHHHQDHDGNSPHSPTAPSSSLYRMTGVGGIGGGTGAGSGYPLYVNPAELTPTTQQLWSSQVPSLSGGLPSMSEDYGVSKAPTVSHQSLPAFSQPFSTRFPRYSPPYTSQQGNTAADVAAGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIA9</accession>
    <name>A0A232FIA9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein sidekick</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_014305</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sidekick family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000179">
        <property type="protein sequence ID" value="OXU30260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FIA9"/>
    <dbReference type="OrthoDB" id="8923679at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002352">
        <property type="entry name" value="Blast:Protein sidekick"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000158">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000209">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000231">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000236">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001715">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001849">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002022">
        <property type="entry name" value="Sidekick, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1824"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="102"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="201"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="295"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="386"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="482"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="593"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="695"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="803"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="901"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1001"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1101"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1201"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1299"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1400"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1507"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1612"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="1707"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1884"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1976"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1887"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1910"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1932"/>
            <end position="1942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU30260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2029" mass="225668" checksum="FD06FD1DE534AB42" modified="2017-10-25" version="1">MGEFEDLTERGLEVSSGEAAVLEMPHIESHPVPDVIWSTSDGIIPYTIKYAKVYHKLLILNAAESDEGSYRARAINSQLGKEENSPFFKLKVTGDPNAEVAPTIVVKPEDTKIIKDQGTTYLHCIANARSLHELRTIWTKDDIPIEDARIAFNFQDSWNRTLILISANLTYTGVYACHVDLRSGGYPTISASAMIEVLEKPTFVAELKRVTLSEYGTTVTLPCDADGVPPPTIQWFRNAEPVDSLLGTRYAMQEDGSLTIKKLTMEDSGMFQCLALNEAGEASSYTWLKAKTSIPIMEIPPQNVTVLDGKDANLNCRAIAAPVPNVTWMYNDTTPVEIAGRVQVLENGDLLIADVKPSDAGKYTCIRANEAGSVNGSAYVSVLVRTQIIQPPVDQSVLLGHTAELKCEVSNDPSVKYDIAWFHNSQVINTRASPRVKMQNDGTLEIGAVRASDVGEYMCSVVSSGGNETRTARLSVIELPFAPINVVASRVEKISPRTINVTWVPGFDGNSPIKSFIVQRREVPELGPLPDTSLNWVTEYSNISASNRWVLFNNLKAAAAYQFRVSAENSVGEGPSSEPSNVVLLPQEPPTGPPLGFVGSARSSSEIITQWQLPAEEHRNGHILGYVLRYKLHGYNETPWMIQNITNEAQKNYLITDLITWKDYIVQIAAYNDKGVGVFTNELRIKTKEGVPEAPPTDVRVKAINSTAVNVWWKPPNPQNINGINQGYKLQAWHNGGFAEENEYKSITVAPNLFDPQAEQNAVIPNLRKYTLYNITVLCFTNPGDGERSAPVSVRTSEDVPGKVENLQFLNISDRALTVKWRPPKEINGVLTFYQLKYTIKDKPDTLRVLNFTADMLSTKIEQLQATTHYTFEVLAWTSKGPGEPSIATIQSGVEPVLPEPPTKLALSNIDAFSIVLQFTPGFNGNASISKWTVQAQTTRNTTWHTISEIYDPDARKIMVEGLTPFMQYKLRLIANNVVGASAPSEPTKEFQTIQAPPSHPPRNVTVRAMSATELRVRWIPLQQVEWYGNPRGYNITYREVRTNKSKSISIDDHTANSYVLENMEEFALYEVYMHAYNDVGSSTLSPKAVERTRESVPSLGPIGVEANATSSTTIVVKWKEVPIEHQNGQIEGYKVYYRANTRSPFQFKNIPSNSTFTTTLTELRKYVQYHVQVLAYTRLGDGALSMPPIRVQTFEDVPGPPSNVSLPDVSFNTARIIWDTPEDPNGDILAFKVMFHLNGSMNHQFAKEFSATTRTFTATNLEPEKYYMFSVTAQSRLGWGKTAYALVLTTNNRERPQPPSKPHVSRSQVQSRQITFSWTPGRDGFAPLRYYTVQQSENSGPFQTIPERVDPSLTSYTANNLKPFTFYQFRIQATNDIGPSAWSNESIQVKTLPAAPSRGVSGLKVVPITTTSIEVHWNPIDELHWSGDHQTGGYRVSYQILSDFPSAVAGPPKEEVKGINETKKTLMDLTEDKYYEVIVAPFNSEGEGPPSLPVTVYVGEAIPTGEPQQVTVEPISSTEVQLKWKPPQANMQNGELLGYKIFYLVTDSPQELEKKQEEEIEVVPASYSMHSLVFLDKYTQYRIQVLAFNPAGDGPRSPPITVRTKQDIPGPPQNLQFSEITLTSLIVSWDPPKMRNGEIVGYVVSYKTSEQNDRFSKQVRQKVTETNLLIQPLEEEVTYTFSVQAETIDLGPPISGNVTTGPQEGSPMAPSGLIITKTVSSVDLQWTNGATGKGPILGYYIETRSKDNSQWLRITRTDNGLLTEYSVSYQNLLPSTLYLFRVIAYNRYGISYPAFSTETILTPSKLYREYAYLQHQPFYRQTWFMVTLAATSVVIIIMVIAVLCVKSKSYKYKQEAQKALEESMAMDIDDRQESDLELYRSRQTGGVSGMGNGCGTLGKRSTLSRKSAHPPPPAVYGKSPPRPSPASVAYHSDEESLKGYDENPDDSSASESENESVQSDPHSFVNHYANVNDSLRQSWKRQKPVRNYSSYTDSEPEGSAVVSLNGGQIIMNNMARSRAPLPGFSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIU3</accession>
    <name>A0A232FIU3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000164">
        <property type="protein sequence ID" value="OXU30388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIU3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="55" mass="6495" checksum="04D2FC6043DA8B1E" modified="2017-10-25" version="1" fragment="single">GSQNIIEREEKLSPLSHRVLKHSERREGVLVSWRVREDPYSSIGYQNTLRGERVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIW2</accession>
    <name>A0A232FIW2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_013494</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000156">
        <property type="protein sequence ID" value="OXU30470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIW2"/>
    <dbReference type="STRING" id="543379.A0A232FIW2"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF158">
        <property type="entry name" value="ORGANIC ANION TRANSPORTING POLYPEPTIDE 33EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="481"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="777"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU30470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114340" checksum="2BDA7687AEECBBAE" modified="2017-10-25" version="1">MKPCNSDTYTIKSIDLKIIPLSIFSQNMTLGPQEIVRSEVEGSFSGPANSLTPESIDCGCSRYQLPRLAKFATRQSFLALLCCIGVLQAAAQAYLHVTSSTIARRFQFDPYLMGWILCTSEIVLVIVGLTVAYWGDRIHRASWLGGTTLIQCATFLTILIPHGSNWLKITTSTDEPVNVTHMSIYAEESPDLCMRMSSRLIALEDPPHYSTLFILIAVQIVTGMANVAYYALGISYLDDNTKKIHVSVYFGVVLATKVLGSILGYILGWSFLRIDAEDLSSIRSYRDQIGAWWLGWPILSVMLAIPAGFMAIFPRKLPSELVEEAAATIIDQSGTLRGSQRIAVKKVGSPDFFPSILRLLTNKILICNVLAAAFFLTALINFIANENIFLESRFYAPRPTGMLLGFGDPLLSRTVTTIIKPLLAGLVIIISGLVIARAKPNARMLVIYSLITLISSALIIFGLAFDNCDKPPIVGAHRGSIVLNRFCNRECGCSRDADFRPVCDSRGTLTFYSPCHAGCTAMDYDGTTKVFSNCSCVEDDTGQGNTEAREGPCGSDSCQVGWLIYEILTIVVYAAAASTIVGDLLISLRSVNVQDKALTIGYSMTLLAFFTYAIGKISYDELAKSTCQHWGLEDRICHLHHSTDLGNYLCFLTAGLIVIAALFKVGVWLFCQDLEMYDPTESEESQPREMKDMSKTQAEPLLQPQATSEQEESNQRTLDTVDDVVEPVVVIESKKLGKENGPVANVDEGEPSRLRYGPLGPGNRRVLKTQFNASIPHIDTDDDLDSSEGSQTLRKGSASQVSYKPLELDSDVESEMSGTLPRSKKLIPNAYDPGTLQVGIRAPFSNKPFPNPENYEDPRKVRSSRDNSPNVAADGSSKTNSFEYSKKRKDDKPLSASRGDFNEVGIPVVEPLETAAKGSMSSLRSPTIMMAITQLDRNPSREILEQTRFTYAPSRKHNTEEMEENRKFRLEKLMQPMNYPEPTARPPSRDQASSGFGSLQDMRERARLPSEISDSRDSLSSKSSTSGPPKKGGPLCTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ24</accession>
    <name>A0A232FJ24_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12493" checksum="F1254FB886214F49" modified="2017-10-25" version="1" fragment="single">KCYPVTIIQYKLRFPGRNRNQFQPKNKLISVELAYLSQECWKRYVTSNVNNNAAKQKKXGGVAWPKRPAVCCFITPVILERRHSSVAIAVILRQEKKTRVQARVVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJK1</accession>
    <name>A0A232FJK1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000106">
        <property type="protein sequence ID" value="OXU30911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJK1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="55" mass="6213" checksum="FF8B4EE916268122" modified="2017-10-25" version="1">MSILPTLGTRNLAERCRHDIRVLRPQKPPSSKTGLISINIDGVLIYCLCRCTLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJL4</accession>
    <name>A0A232FJL4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000126">
        <property type="protein sequence ID" value="OXU30730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJL4"/>
    <dbReference type="STRING" id="543379.A0A232FJL4"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000004">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="308"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU30730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="598" mass="67522" checksum="5D07DF345B34BDC2" modified="2017-10-25" version="1">MLVLFETPAGYAIFKLLDENKLAKTDNLYLDFETPEGASKVLKLKHFEKFADTTEALAATTAAVEGKLCKSLKKMLKKQCSEVQEQLAVADAKLGNAIKEKLSLPCVSNTAVQELMRCIRSQMDSLLAGLPKKEITAMALGLAHSLSRYKLKFSPDKIDTMIIQAVCLLDDLDKELNNYVMRCREWYDLIFFAVYYVFKNLYHFNYNHIYCRYGWHFPELGKIITDNIAFVKTVKIIGTRENAIQSDLSDILPEEVEEKVKEAAEISMGTEISQDDILNILHLCDQVIEISSYRSQLYDYLKSRMMAVSPNLSVLVGDLVGARLVSHAGSLINLAKHPASTLQILGAEKALFRALKTKKDTPKYGLIYHSQLVGQATTKNKGKMSRMLAAKASLCTRVDALGEESSFELGAEHKVKLEQRLRMLEEGNIRRLSGTAKAKAKFEKFHTKSEVLEYPTAVDSTLQSQKRRHSEIEEKKPLIEVIGESSEGPEKPKKKKRKTEDDADVEIKQEVEEEAQEGEGKKKKKKKKQEVEEVKEEPVEAAEAEEEPKKKKKKKKKDHTEEADTSQAAEEEMDTTVAEETVTGEKKKKKKKKSQSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKK5</accession>
    <name>A0A232FKK5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000073">
        <property type="protein sequence ID" value="OXU31264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKK5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="193" mass="22943" checksum="331E1B089982389B" modified="2017-10-25" version="1">MFNTYVKAQNVTSDLEKYQIKKDSVQLQTKQLKMIIYIILALDEQLPKKSSTFYFNAEKNESPNRFEATIKQNKILNLTNLTVKKKMKINNNKVQKVRLQRDLFGRMLAISMNANTNIDKIFTFPLIPVLIIRCKKRSSNTHRHLFDRRLLSNLLYERRIKNQIVTSNNKAREIQLNFERYFAPPIKNYERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL27</accession>
    <name>A0A232FL27_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL27"/>
    <dbReference type="STRING" id="543379.A0A232FL27"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="382" mass="43330" checksum="2DD56875C0C83489" modified="2017-10-25" version="1">MQGHHASGGRPSVLPSLTPGLLPDLVAAGGFGSLTPMLLAALVLWMMVADWLTSFLSLGWSLARLGAPFERRNSNSPKRRQCSSKLELMVHQRLLRLEKILRDHCFCLANSLWCKFDDDVVSKCSKQEAIEHNYGGQDEDISMTVKHCTNAYMLVYIRNSELEHVLQEVREEDIPQEPAVTPIHVISSSILDRETSTTTTKYRCHQILPMVFGLNISYGKIIQIELENTSVGYDDFNLVFRLCNNTVYGLSLPLAAWIQLREQSRVMRICWISESPFPASASAMLIGHLNCWGVIRRQYAKILIVRKPLLVFKRVTLDRLKALSKIIDHRIKYLLKGKEAIAIIVKELGDYSRDKLINSENAMRDFDETLISSMAWGVLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL93</accession>
    <name>A0A232FL93_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000052">
        <property type="protein sequence ID" value="OXU31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL93"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9702" checksum="7FDFACB3C65C1036" modified="2017-10-25" version="1">MINERKKFVEYNCLILRLSSNYTKNFAFYLILLLLSDQRDFVLENPSDLGSVPPARFFLSSLLPKLLWIYTTDIYYGLEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLB4</accession>
    <name>A0A232FLB4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000070">
        <property type="protein sequence ID" value="OXU31300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLB4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="9284" checksum="CE0ACAD73BFFE93C" modified="2017-10-25" version="1">MVTLRDALKEVVDGVADDSEPRVGGVKEHPSLNILGCLNVPGHRAEDAVGAGWCAKRDLPVAVRGRQQQLRRKGGWSGHRQAFSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLW1</accession>
    <name>A0A232FLW1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000053">
        <property type="protein sequence ID" value="OXU31500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLW1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="203" mass="23016" checksum="563D93E4E62ED7E2" modified="2017-10-25" version="1">MNSALNQNNLPWNWNVYYFFFGKHEDDVWLLLSGFLLDCVVVSIPLPEDPLLFVMQLIMTLIGAYARRRYMYLDNLLFKEFASFLMLAIMFITGHQLLMSALTMLISAFLAIHATKRKPLVQESIETSLAVILFLTVIVFGTHPFTVIYAILTSVFSPFSVMLYLKLWTLTFEPEVKTTTSNGNETSFITSNDAAVAATNSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLZ4</accession>
    <name>A0A232FLZ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_014950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLZ4"/>
    <dbReference type="STRING" id="543379.A0A232FLZ4"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000019">
        <property type="entry name" value="Hydroxyacylglutathione hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="70"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="314" mass="35142" checksum="160591B281C8D88B" modified="2017-10-25" version="1">MLKTTLSLCSSRLKAGLCNVYFNGTGYLFCYDLIAARHIPISRLRRLIHSSCVSVDHNRMKVEILPALEDNYMYLIIDEDTQEAAIVDPVSPDQVLAAVKENNCKLTKVLTTHHHWDHAGGNKCLSCSVPDVQVYGGDDRIDALTCKVGHGSVINLGNLKIECLHTPCHTRGHICYYVTKDCAEPAVFTGDTLFSGGCGRFFEGTAEQMNKALNEILAKLPDHTKVYCGHEYTISNLKYGRQVEPNNQALLEKMEWACCRRKNNLPTIPSTIGEEKLFNPFMRVCEPTVKAHTQKCDPIDVMASLRSEKDNFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FP19</accession>
    <name>A0A232FP19_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000003">
        <property type="protein sequence ID" value="OXU32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FP19"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218139" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="45" mass="5366" checksum="76CE316C833D9C26" modified="2017-10-25" version="1">MAHTIKVCKFCLFVTKVVLFRTARLAHERSKCDKHGEKKDYFSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE32</accession>
    <name>A0A232EE32_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005709">
        <property type="protein sequence ID" value="OXU16588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE32"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="81" mass="9079" checksum="B98A9267308FE7BC" modified="2017-10-25" version="1">MLPTSADLDRYAQADSVYKFVCIVMGGLLVYKLPTNHITIVTKRQACAIISAVINSYTIKQKMLPTSADLDRYAQDIRNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEK7</accession>
    <name>A0A232EEK7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005287">
        <property type="protein sequence ID" value="OXU16790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEK7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="13706" checksum="56F91059BA7CDEE6" modified="2017-10-25" version="1">MSNSSSSESSSDGEIDPRVLKKLLHKLIDKTSKKKSDRKNRKDSSASGISARDKVSTKPSSSANEKVPDEKSYRGRVLRAKMKAYEQEYREQLIRQEKAQEEAERLAAILEAFESFKQAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEL6</accession>
    <name>A0A232EEL6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Solute carrier family 3 member 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005286">
        <property type="protein sequence ID" value="OXU16791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEL6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Solute carrier family 3 member 2 N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="13272" checksum="CF8F227C044188B5" modified="2017-10-25" version="1">MWIIVDRCRSSRSLRQGCWTSSGVSCKRNVRKKMLPEETTYLLTNPASKAMRINIPEKYITRELTREDLEYYTADPLWMKIRLFLFWSFWLAFLLVLFLSIFIYIFPSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEV9</accession>
    <name>A0A232EEV9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005209">
        <property type="protein sequence ID" value="OXU16885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEV9"/>
    <dbReference type="STRING" id="543379.A0A232EEV9"/>
    <dbReference type="OrthoDB" id="10263520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF4">
        <property type="entry name" value="TECTONIC-LIKE COMPLEX MEMBER MKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU16885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="261" mass="29189" checksum="6B935EF090845B7F" modified="2017-10-25" version="1">MMISVQELQRMRSLKEAQLFHELTAPQPRVLRLFLNLDIGSARDFGCDEAGLFVSYFVDLPKHWRSTGQRLAGRTQRSKAKDGRVNFGYCAEISLDLDLAAIDESEARTASWPSLLMSVASLDNWTRYRIEGYGSLPLPSTAGNFAYELKTWRPSGGIIDSLRRFFTGGSCELDDITYCAIPGMHEGPSLDKTNLRVVPSGSVELRINCVQQCQNFARERDLDPNSIGRLNAGKLLNSVDDVLSQFKAARERMIQARAMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFP9</accession>
    <name>A0A232EFP9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004950">
        <property type="protein sequence ID" value="OXU17199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFP9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11971" checksum="CC4B7EFC2BB3739B" modified="2017-10-25" version="1" fragment="single">WVHCISCWLKIDRKEPNFHITQCSRVYCTKCIVLAEKKMLSMWRNRYYIFACISGVCTPLEIPTITKVPRSTGYYIASYNSSNSSSNYQMITPKSDFSNYSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG83</accession>
    <name>A0A232EG83_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01004856">
        <property type="protein sequence ID" value="OXU17332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG83"/>
    <dbReference type="STRING" id="543379.A0A232EG83"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012782467" description="phospholipase A1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="91"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU17332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="356" mass="40156" checksum="A1F1AF0ADC6AC6A1" modified="2017-10-25" version="1">MKILAFVIIVGFLHLLLVKDVNSWSWEWLTRWFTSGRRKMEKVSNKTLQIPLSVSKSISEVAATGAVFLRDSAKLNCLGLPTKLFANTIYSSDTEAEDVRFYFFSQKTPGYSGIKIEDDFTLEHVDYSVYRDTIVLVHGFMSSGKEQWLVDMKDAFLKYDDVNVIVVDWQKGSNTWNYIAAAANTQIVGQQIASLFAHIRQFQFDKNVTNVADWGKIHFIGHSLGSHISARAAYGIHESQWNRPDQPSRSAWNVSRITGLDPAQPCFVTADETLKLGKDDAEYVDVIHTNARQLIHLGLGLPEQLGFVDFYPNGGQIQPGCSNGALDGFEYRRGLVVTPNILHTKMPYTNLFLHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG93</accession>
    <name>A0A232EG93_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004850">
        <property type="protein sequence ID" value="OXU17342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG93"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="29" mass="3468" checksum="9146BC2BCF57BC19" modified="2017-10-25" version="1">MVHWCLDDTKIWFTTESGFKRKIGIRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGQ3</accession>
    <name>A0A232EGQ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004736">
        <property type="protein sequence ID" value="OXU17492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGQ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="38" mass="4613" checksum="9F1415609D652900" modified="2017-10-25" version="1">MRWRPWRDDRVSAVQARGSRFKPGVRHVFVALFTRNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH03</accession>
    <name>A0A232EH03_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004644">
        <property type="protein sequence ID" value="OXU17613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH03"/>
    <dbReference type="STRING" id="543379.A0A232EH03"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="246" mass="28504" checksum="7A9749FCCE4A1609" modified="2017-10-25" version="1">MLNFVIIGLNSEFEEKFSIRVSGGESTFNSIGHLNRHIGHHNSHYWSAINQHWMQQIDNQHRWNINVWCGRINGNLIGPYFFEGCGCNKMELNHSTEILNDRFPNRSIGRGGPIAWPPRSPGLIPLDFYLWGYHKNTVYREKLTTAYDMRMRIQNACANIPRNVLIRTVGHFQQRLQLCLQVGLNGVQNPIVQPPRGVCRVTLMPKIKFWVLNIKFVSIAIKIPFEEQTQHITLKAFLHEIFACID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH13</accession>
    <name>A0A232EH13_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004617">
        <property type="protein sequence ID" value="OXU17650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH13"/>
    <dbReference type="STRING" id="543379.A0A232EH13"/>
    <dbReference type="OrthoDB" id="294696at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02996">
        <property type="entry name" value="PDI_a_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03072">
        <property type="entry name" value="PDI_b'_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03070">
        <property type="entry name" value="PDI_b_ERp44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000051">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000074">
        <property type="entry name" value="endoplasmic reticulum resident protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052643">
        <property type="entry name" value="ERP44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041870">
        <property type="entry name" value="ERp44_PDI_b_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041862">
        <property type="entry name" value="ERp44_PDI_b_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46295:SF1">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624334" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="426" mass="48948" checksum="2404F7FB2A7A6320" modified="2017-10-25" version="1">MLSYCDSRAARLVGIVCLLIFAQCTSVSGEATGATSLNQDNIDMTLASNELVFINFYAEWCRFSNMLQPIFDEASDKVREAFPEAGRVVMGKVDCDKESSIASRFHITKYPTLKVIRNGQPSKREYRGQRSVEAFVEFIKKQLEDPIKEFHDLKELRDLDDKKRMIIGYFDRKEVPEYQLFRRVATNLKDDCQFHVGFGTCSKEKCDIGQHLPLLDSSKAMHPPGQPIIVFRSDKALSNDDDETYHGSLTNYDELNIWAQEKCVPLVREITFENAEELTEEGLPFLILFHDSKDAESVKQYKDIVMNTMYDEKQNVNFLTADGYKFAHPLHHLGKKLSDLPLIAIDSFRHMYLFPNFQDIFVPGKLKAFLQDLYSGKLHREFHYGPDPNNNNVPQLEGKVPTSPPESTFKKLAPSKNRYTLLRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-05-29" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHD3</accession>
    <name>A0A232EHD3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004523">
        <property type="protein sequence ID" value="OXU17770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHD3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7575" checksum="EC4A95B883E5FBF6" modified="2017-10-25" version="1" fragment="single">IPLNKGYFSTNLKGLENNVTRHLFDVGTWFCIVLNMYNKKKKLRECTLTFVFFGFSNQKMAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHI2</accession>
    <name>A0A232EHI2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004514">
        <property type="protein sequence ID" value="OXU17794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="18757" checksum="60CB402E0B56C0D6" modified="2017-10-25" version="1" fragment="single">MFKVKNFRSRKPLGECSSAFRARRLRLIDKAHSEDLVDQAFIDVSSSCVKNFRSRKPLGECSSAYRARRLRLIDKAHSEDLVDQAFIDVSSSCVSHNLEVPSDSFHEDVIEVNHENDIVSCVSDNPVEHPIAEDQVHDDDLESATFSSVASDDSFHDNLENXLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI76</accession>
    <name>A0A232EI76_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004308">
        <property type="protein sequence ID" value="OXU18070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI76"/>
    <dbReference type="STRING" id="543379.A0A232EI76"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="408" mass="48232" checksum="428909A38117A51F" modified="2017-10-25" version="1">MFKKVKKKYSNGKQWKIFSATDFLSLIKPSLLVCRFFGLISYKILNGKIEQSKNFGSYCAIVTFVYICASLLILYIINVSPYMNRASTWMLQGNCFYTLVNFMLVSNFVFKSSTIKILQNLADTTAKLPNEKFVKISKWIHSKDLVLYLLLLLHVPKVFVGNIYAVLSKIIGTYAAMTIYLLDFQYNSYVFIIASCFEHINEELVQLKYNACKERGHLLRRVYHHQFNPLLFVKLRYLKQWHYELNEIIRKINSNFSLQVVATVIMTFTELTFGLYFYILDRRHKIRSLDKEIWYFYYHTMVMYFSTKLLLLTLTCQYANNENYKTRTIVNEIIISTDNKLFKEEIYLFSLQLLHTDNKFIAKGIQLDATLLTGVDGKRYIHISFNTNTIFNNKLIYMNKKLEMFTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIF0</accession>
    <name>A0A232EIF0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004286">
        <property type="protein sequence ID" value="OXU18102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIF0"/>
    <dbReference type="STRING" id="543379.A0A232EIF0"/>
    <dbReference type="OrthoDB" id="7694005at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="144" mass="16428" checksum="C4DF0C79706C1D4A" modified="2017-10-25" version="1">MQFLDIGSLDIDVEEKKNLPCNNFDEKQNQIRILHSRKTSEISGMFKAPPGVNPFHVGATKIKKFSSGGSKLVFIWPQKASSRRRMPNVLIPIFRLFLEGFIILDRLHLWPGEFMPSDLPAILPTPLPPIKCNVIEPRWFDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIT6</accession>
    <name>A0A232EIT6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004173">
        <property type="protein sequence ID" value="OXU18242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIT6"/>
    <dbReference type="STRING" id="543379.A0A232EIT6"/>
    <dbReference type="OrthoDB" id="5865932at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045811">
        <property type="entry name" value="MTP_lip-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039988">
        <property type="entry name" value="MTTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024:SF0">
        <property type="entry name" value="MICROSOMAL TRIACYLGLYCEROL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024">
        <property type="entry name" value="MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19444">
        <property type="entry name" value="MTP_lip_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013099268" description="Vitellogenin domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU18242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="879" mass="97603" checksum="D61E9A646065FE62" modified="2017-10-25" version="1">MTAMFAKILCCLLVVKVASAQKWEIGSGLVYDLTTTVLLGETPITQIRNDSTGDVGFQLTNKLTVLPLWRDPTDAETILLSIKADSLQLWIKSRKAPEPEGFVEHSSRLEDIPKDPILLLLRSGKITNVFANSAESLSSLNLKRGFASIFQYKTYDGALQETDSSGVCNVTYKSHNPKLFEKIKHTCKRIKNQHTNRLLGVKVSNLHRTTYDLTKSLHLRVLTDYEKHEMSLTLKPDARTSVTTHRNLQLLPDAIKENPIVASTYTEVINTFDSRYVEVSIESQNEHIPCPESGCVTLDTVLENSRSSLESSALGTAKAASAFLKLVTLIRDSSADALSKILKSPKNHDLLPQLYDLYGSASTLAAHQAAMKALRQDDIGDNTERYLWALSTSPFPDPDIIKDVLKRSEETIQNDKLSETLALTAAAMAKQYGTPSVVEKVKDSLELGLYSCTGDECKIKFLRSLGNLGTKTVIPTLLKYTNRTRAMSVVAWKAIGSFHADAITSEIKNIAMKTFLQLGGQKVDSSIRTLALNIILENSPSVEEMQQLLVYLTYNDPVYEVKKYLVQRIQQLASTNVRFLDVYQEAARREYKKAINYNTFAQKGLSTAFTRSFLRSSTSNGSLVTIQEISSGLLKRGVVDIVLESDANKYTFFSLGLFAGGLNSFVSSNDQEENEVPAENEPATAGMELSFLDVDIRPFVFFSGQGELMGHVWSGTASERTSAFQTTVNLHRYREVIALGSGFVVEIGVEGAMSFDLAGKISLSLWSRTAESLVDMQAGVAIHGISKILTNFVQSRAEYTFTMEPKLELATDVDFSGPVTLCMRLAQPQTLAKHNIYKVERIPGSRHRLRKTRRLTLFSPARSYLLNKKNNEMCSKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIU9</accession>
    <name>A0A232EIU9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004174">
        <property type="protein sequence ID" value="OXU18238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIU9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="61" mass="7290" checksum="95DD3B45C9FBEDE6" modified="2017-10-25" version="1">MIFTPRHQKPRSTPPRPCHRLPWQASYCYSSGTQSMHWQPLNSKYRNILLYFLEKAIPICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ52</accession>
    <name>A0A232EJ52_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004122">
        <property type="protein sequence ID" value="OXU18338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ52"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12192" checksum="25DBD29B137CF7CF" modified="2017-10-25" version="1">MDVEEVNYSLDEDFGELTDKDKTVELVGYVCFDLFKFPYGVTSQDRVLNTQANLKMDVEEVNYSLDEDFGELTDKDKTVELVGYVCFVEAPTKVKGYDLFKFGLTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJL8</accession>
    <name>A0A232EJL8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_006087</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01003970">
        <property type="protein sequence ID" value="OXU18556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EJL8"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000405">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000324">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="114"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU18556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="516" mass="59191" checksum="4979CF151475ED19" modified="2017-10-25" version="1" fragment="single">RVANQTLTASPQPAVTVEGPVFKMSPPTNDVTNGVVVAAPGDIVAPARLPTSPAATQQQQQQLNNPTGQQQQSLDTATPTTTVVPTHKRSPKDFIFGKVIVFIHAYYTPRDSSTKTNDAPFFCPRAQVYIAKDIHTSKEYAIKVCDKRHIIKEKKSEYVKREKEVLNMLAGAKHSFVRLFCTFQDLERLYFVLSYAKNGELLPYINKVGSFDIECTKFYSAEILRGLEYLHGLGIIHRDLKPENILLDENMHVLITDFGSAKILKEDPEQLALDKTNSGEYRRERRNSFVGTAQYVSPELLTDKTTSRASDLWALGCIVYQMXXXXXXXXIGEPSDDDDDESSSAEQQQQQQQKEQQQRKLEEDEQKRRAERREKQRRLKLDKSKKKTGISDLTQEEIARRLDEQKANNQWDSFVDGNLIVKQGFVSKRKGLFARRRMLLLTTGPHLYYVDPVNMVLKGEIPWSKELRVEPKNFKIFFVHTPNRTYYLEDPEGYALEWCQAIEEVRVHYYDVKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK23</accession>
    <name>A0A232EK23_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003896">
        <property type="protein sequence ID" value="OXU18695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK23"/>
    <dbReference type="STRING" id="543379.A0A232EK23"/>
    <dbReference type="OrthoDB" id="5920040at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="172" mass="18910" checksum="714369740D639454" modified="2017-10-25" version="1">MLSSPFICQIIMLRSLSKRFAFETSASTVEGQAMLLWQGLKLADPRFGTPGNIKLLMGADVLPDILRVGLLRRSDLTAQRTAVGLTISGRAPTAHAATQTSACLVLRSEINSPWHQQLMGALNRFWEMEEMPRSIRQSPEDEAKFESTSAMSTFSASSGVPMKIRSLHIISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL91</accession>
    <name>A0A232EL91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003603">
        <property type="protein sequence ID" value="OXU19120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL91"/>
    <dbReference type="STRING" id="543379.A0A232EL91"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990525">
        <property type="term" value="F:BIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045751">
        <property type="term" value="P:negative regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000001">
        <property type="entry name" value="Caspase-3 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="227"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="371"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU19120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="82826" checksum="4434D20226C49A1A" modified="2017-10-25" version="1">MDILLFYLVKSLRDSIVQASTSSGALEYKFRITSEMCDSKDEKSFEESSRGQVLFHGFEDFDVAELVENKLSDIDEEEDIILRQLPRTPVASAARGKRRRRASDVIDSMGERGCQLYNFNSPATCSSSASPYSYYCGSSTPASSSGFTTPRRGTNRNAISPDQGYATTPEFVQRTVIPEWMLRRIDSHDATVPIRNDENNYSTSPAEARARMSAQKDADRYNMEHRNRGKCVIFNHETFDTGFETREGSSVDARRIEQTFQQLGFTVEICDDYEHSGVMNKLNELSEEDHSENDCLCIFVLTHGLKNDLICAKDVVYKLENVWKPFTADKCTSLAGKPKLFFFSSIRIGDNLDGGIKMMRSGTTETDSSSASYQIPTHADFLFAHSTVQGFYSWRNPEEGTWYVQSLCDVFDEYAATQDLAKLMTITARKVATNFASYNDLDPMLHGKKQVPSVISSLIRDVYFTPKNYGRSKCQYDICQNKIQEASGYECEQTCHEHNYIQNIISLLIFVVNKFFCESRKCHDNLEDVLNPNEVNKPEIKRRLYDLLGSDDNLKNHLTQNKCDSSRFENSHKNEKIGCKLDSVQKLYQSSGNCCIHRRLPRHFRQNICLLNPLKCREVKIRKVEKCCGDMPNFIELRPMKLVLPNNKTSSQYFQKRLTIPKQKLNTVIEKISLSKRKRFRKLFNSLHLFCIKPKIYIFRKYCFCKYSKKYFYARKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELF8</accession>
    <name>A0A232ELF8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003561">
        <property type="protein sequence ID" value="OXU19196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELF8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="145" mass="15930" checksum="8CA6FF49298452C2" modified="2017-10-25" version="1">MPGQRSELCLVVVRRMTPVLAHTHYSLDAAEPLEDEDNAGLRGVCRCERGVYSSTSGNSLCNVEPSRTRDRLGAYVILRICVPLIHIEFATNLVDIGLGVVDLMLSFAVGSGDALCDLQHALALVSSGRYQRYDRVVLIVTRAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELI9</accession>
    <name>A0A232ELI9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003545">
        <property type="protein sequence ID" value="OXU19229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELI9"/>
    <dbReference type="STRING" id="543379.A0A232ELI9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57633" checksum="2C8BC9C13D1E9B31" modified="2017-10-25" version="1" fragment="single">MALTPQPKNLRNLQWNYLSFRQRRASTQELSKDFDVVILCETWLNPSDYASLKGFVVIRNDRPAGRGGGTAICIRSSIPFKSISTYNSFNFFESNAVSIITSQGELLIVSIYKPPNLSFDNNHIHRFLTSISSFKSIFIGSSYTCNLGDYLLSSFSDHDLLLLNNGSRTYLNRRNPSNPSCLLHPIRLPPSLHHFLLVCKRGQSLQRPLPRFLFLCIHAPFSSFRSHRPNYRRITQEDSLFNFSFDNLLVDASLSDKYILLTSTILSTINPFLSPSRSSTKRPRPPEPPWLNADCSQAESARKRALKDFRRNSNLYANLLEAEDRARFVFSNAKKSSYQEACASLTPSSDPNKFWELIKRFKHRNLGSSDYIANIEKQSNLIPSICPPSCFYPNFPSVFTPSLFTLNFFCKHFTRPELDIAVNQCLAKPNSVPGLDKINNLLISHLPDNIIDQLLSIFNGFYLKGIFPPCWSNFLVFFIPKFRPISLAQSPLKIFERLILRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELJ2</accession>
    <name>A0A232ELJ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003545">
        <property type="protein sequence ID" value="OXU19226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELJ2"/>
    <dbReference type="OrthoDB" id="6119432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="10098" checksum="86DEA5EE2D96993A" modified="2017-10-25" version="1">MTDELRSYGEGNHTEHHHSATIECCKVKGIRLNYNNSLKINFESIKSLIDDKFGENADKSDNDTVKDKRTIKVHTYTRGCDLRSVQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELL8</accession>
    <name>A0A232ELL8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bee-milk protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003548">
        <property type="protein sequence ID" value="OXU19221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELL8"/>
    <dbReference type="STRING" id="543379.A0A232ELL8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="49474" checksum="FE26C55A0573AC45" modified="2017-10-25" version="1">MVLHVHQNKKVPLITARQESSVSPLILQRNVYAAVTMILLVVSIALILQASAAFPYRYANDDTEILVAATDGVYRTSLDGFDTFLVAKAVNATGVDYHYDKHLVFWSDVATHRIYSKDLFNESSEIKTVVAGPNDWEPRAIAVDYVNDKIYAMDQRGRKIDVFELDGSKRISGIQVNLTDPEVDDGDTLDVGPSTMDIVVDPYEGFVFYGDHNKVIKRVYDRLLVDNFQAISHQRVMRATMDFTSVECVGQKARISGLAVDPYVKSFYYADAQHVLWETNYKGERKFRFNIYEDEQGSLLGRFMAPRSLSKYNYREFFWLEDLVEQGYPSLFHLWFYRSPQAESVYTDMKSGWTIRVRPSSVPKSRIVSVKVLSWFLHLRREQWRYRLLKINLFFQDYAKGCEKADCEYMCLVSNAMYSSVTHSCFDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELX6</accession>
    <name>A0A232ELX6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003504">
        <property type="protein sequence ID" value="OXU19312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELX6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19310" checksum="C66732779F2BB096" modified="2017-10-25" version="1">MENLTEQGEKAKKELSRSEIQFGMLSKNEKARGRRSETGWTLWIMLCQTYPTFIRQVALKKSKESLGLMLKIAEISPNQQHIQKEDKASQTIEASNAVTTRTLNKYKTSKNKGVASKGKKPPGVIVIQIALQAANPRQDPKTHYLRQNGSFYKRKGRLAEHKYSFRKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM63</accession>
    <name>A0A232EM63_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01003426">
        <property type="protein sequence ID" value="OXU19427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM63"/>
    <dbReference type="STRING" id="543379.A0A232EM63"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF186">
        <property type="entry name" value="FI22312P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325595" description="phospholipase A1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="60"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU19427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="550" mass="60905" checksum="40E2B0FDA35DC292" modified="2017-10-25" version="1">MRRSLILFSILLSVGSIRHNVRMPERRNRMLMMQRRLGNGRGDVGQKVCYVMIASSAELLGCFTDRQPLALKRPPQDPSVIKTQFHLYTREKRKEPDILNYGDKLQSMSQSKFNGTRKLKVIIHGYKGSGNNEGAIAGVQAFLDLEDANVVVVDWAKGAGSTYGLAVSNVELVGRQLGLILLDAVHMGVNPRNIHLVGFSLGAHVAGCASEVLKKNNILLGRITGLDPASPFFRVHLFREKSRKLDASDARLVDVIHTDGSVDFADGFGLLKPIGHIDFFPNGGRQQPGCKDVKNSVVVSHLNEGSLRLTFLTLQLPSLPYNNCYAVKTCAMLHEDSLDIHIACSHVRSWFLFVESLQSHAHNGCKFETWPCKRRFGSYAAGSCFPPEESTAAPELGYAADHGPTGLYYLPTRTEPPYCGYPLRAAVKVAEVEFRPKGVLSLDAIACFSQSALPPLSSLNNRNNPQPTFYDVEAADFGAFHANVTEIELHIKFEATIPENKPPEVVYPEILLINKIVLEDRRGHRWELCNLNLSVGSREESLTLKSQKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMK0</accession>
    <name>A0A232EMK0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003344">
        <property type="protein sequence ID" value="OXU19580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMK0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="25" mass="2825" checksum="9004CEA99CD96AD0" modified="2017-10-25" version="1">MIQKKTLIVTVRGFFGLLVSFLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMR2</accession>
    <name>A0A232EMR2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Myosin-VIIa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_006439</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003312">
        <property type="protein sequence ID" value="OXU19644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EMR2"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016461">
        <property type="term" value="C:unconventional myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17092">
        <property type="entry name" value="FERM1_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17093">
        <property type="entry name" value="FERM2_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13198">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13199">
        <property type="entry name" value="FERM_C2_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01381">
        <property type="entry name" value="MYSc_Myo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000012">
        <property type="entry name" value="Myosin VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000013">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000075">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000079">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000036">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000051">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041794">
        <property type="entry name" value="MyoVII_FERM_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036106">
        <property type="entry name" value="MYSc_Myo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 12" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="17">
        <location>
            <begin position="67"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="16">
        <location>
            <begin position="1017"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="15">
        <location>
            <begin position="1258"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="1566"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="16">
        <location>
            <begin position="1710"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="15">
        <location>
            <begin position="1864"/>
            <end position="2167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="12">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="954"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU19644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2176" mass="252313" checksum="F87688BB6ADD1970" modified="2017-10-25" version="1">MKTSFENQSIGDYIWIEPISGKEFDVAIGARVVSAEGRRIQVKDDDNKEQWLTPERRIKAMHATSVQGVEDMISLGDLHEAGILRNLLIRYNEHLIYTYTGSILVAVNPYQILPIYTAEQIKLYKDRKIGELPPHIFAIGDNSYAHMNRYGQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANPILEAFGNAKTVRNDNSSRFGKYIDIHFNDQGVIEGAKIEQYLLEKSRIVSQSLDERNYHIFYCMLAGLSKEEKQKLELEDASTYKYLTGGGSITCEGRDDAAEFADIRSAMKVLLFTDSEIWEILKLLAAVLHMGNVKYKATVIGKNTLPIHNLDATEIPEQTNVKRVAQLLGVPVQSLIDALTRRTIFASGETVVSTLSRDQSVDIRDAFVKGIYGRLFIHIVKKINEAIFRPKHKSRSAIGVLDIFGFENFNHNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEGINWQHIEFVDNQDALDLIAIKQLNIMALIDEESKFPKGTDQTMLAKIHKTHGAHRNYLKPKSDINTSFGLNHFAGVVFYDTRSFLEKNRDTFSADLLQLIHISSNKFLQTCFVEDIGMGSETRKRAPTLSTQFKKSLDSLMKTLANCQPFFIRCIKPNEYKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHSFSEFVERYRFLIPGIAPAHKTDCRYATTKICHVVLGRSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQKNIRGWVYRRRFLRMRAAAIQIQKYWRGYAQRQRYKRMRIGYMRLQALIRSRVLSHRFRHLRGHIVALQARARGHLVRRAYRKKMWAIVKIQAHVRRMIAQRRYKKLKYEYRLHIEALRLRKKEERELKDQGNKRAKEIADQHFRERMQELERKEYEMEMEDRRRMEIKKNLINDAAKKQDEPVDDSKLVEAMFDFLPDSSSEAPTPARETSVFNDLPAPKADQQEIISPVQTASEDEEDLSEFKFQKFAATYFQGNITHHYSRKPLKHPLLPLHTQGDQLAAQALWITILRFTGDLPEPRFHTMDRDNTSVMSKVTATLGRNFIRSKEFQEAQMMGVDPDSFLKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQEDEYTADSYQSWLEARPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPSKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEDRLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLRDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTEDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYYIEYHTDMNVERLFTLLPNYIPDYCLTDVDKAIERWGHLVLQAYKKSYYLKEKVPALRVKEDIVGYAKFKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITTVSSQKTNKMFTQTFSLSTVRGEEFTFQSPSAEDIRDLVVYFLEGLKKRSKYAIALQDYKGNSESSSFLTFQKGDLITLEDDNGDENVYNSGWCVGVCERTGEKGHFPAETVYVLPTLSKPPNDILSLFSVNGTENGRRLYPQQMNGIETRDKPHTLMEYAIDHFRPPPKKTMSKALTLSTARRYPDDLWRHSREPIKLPLLRKLIAKDELAEEAVFAFNAILKYMGDLPTKRPRIGNEYTDLIFDGPLKNEILRDEIYCQIMKQLTDNRNRLSEERGWELMWLATGLFTCSQSLLKELTLFLRTRRHRISQDSLQRLQKTLRNGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTRAKDFCQNIAQRLNLRSSEGFSLFVKIADKVISVPEGDFFFDFVRHLTDWMRKAHPTRDGLSPQFTYQVFFMKKLWTNTVPGKDRNADLIFHFHQELPKLLRGYHKCTKEEASRLAALVYRVRFGESKQELQAIPQMLRELIPGDLVKTQSSNEWKRSIIAAYNHDAGMSPEDAKITFLKIVYRWPTFGSAFFDVKQSTEPDYPEQLLIAINKHGVSLIHPQSKDILVTHPFTRISNWSSGNNYFHMTIGNLVRGSKLLCETSLGYKMDDLLTSYISLMLTNMNKQRTIRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENT0</accession>
    <name>A0A232ENT0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tumor protein p53-inducible nuclear protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001186</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003070">
        <property type="protein sequence ID" value="OXU20029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ENT0"/>
    <dbReference type="OrthoDB" id="10041339at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029431">
        <property type="entry name" value="TP53INP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671:SF3">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14839">
        <property type="entry name" value="DOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31508" checksum="4A8859CF0B98A0A1" modified="2017-10-25" version="1">MLSRLASYLLRGAASGADDGEAPPRDEEVDAAPDGVASIPVEARLRQVEVEGDDWILIDRNVEGFAGMDESWYVTPPACFTQPGPVHVETSPLEDLLIEHPSMSVYRAAGSSXXXXXXPEAKKPADNARLPLASRNANLQAVSTTTTTQATSLVRAEGQASSRSKAKANNNNSNSSSNNNRPSHYNHHHHHHRHHHNQGGAVAEQAPRRSSIRDLRNARGDENVRIVQIRSAQKMLEKRTSQSSKRNRLERGNKAREVXSSGKGRRPRRQDRLRLNNSGANNNRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPJ0</accession>
    <name>A0A232EPJ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002936">
        <property type="protein sequence ID" value="OXU20263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPJ0"/>
    <dbReference type="OrthoDB" id="10670333at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="202" mass="22888" checksum="4E66EFC09E31B906" modified="2017-10-25" version="1">MCSDKNDFTSVSSMDVESTKQLPLELSPNSLENVEDFNNQHRESTGLYLDNFAKECKSSKISDRFSSDDSDLSELDSSDSESVSESNDTCGATNESDLATDLRKWSKKNLISYVHLDELLQILQPYHSDLPSSMENFDNFDSDLEGQMFDDLQQHLLCTTNTKSLMQAFDKKKVIDDSTLLTTIGAVINNSYDWNDYRSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPT8</accession>
    <name>A0A232EPT8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002911">
        <property type="protein sequence ID" value="OXU20337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EPT8"/>
    <dbReference type="OrthoDB" id="8856548at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="2994"/>
            <end position="3022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1985"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2219"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2510"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2904"/>
            <end position="2931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3092"/>
            <end position="3131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1065"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2238"/>
            <end position="2249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2511"/>
            <end position="2521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2907"/>
            <end position="2916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="3118"/>
            <end position="3131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="3131" mass="355189" checksum="2659A1C287573CAC" modified="2017-10-25" version="1">MHISNRHSTAVLNDVTQPIDEYGKNVTHSNNTRVFQPKLIVTERSKKQYGPMYVNALREALFTHFEKPYKAPEVPLSIIQEGDNVSKYVCRQCKDCFHHQSSLEEHTFRGSWILGYWCTDCFQECEHLSGKKLYCAKCIKLRIQKFKALQVRGLKKRNDPGIVKIFFNPCQLLEHMQMHNSEDIAVNQLMLLPFPSGIGKEYFPHLKMISEALMDFMFLTNIHIADWLVQNKIYKWWRMAKGDNPVANIIKRYPFEVQQIKQLLSCNTKGNQTSKCSLNISNVSICDNKKNNVKNTENLLDKNKHRSSVSSSNLMRLNTSETDDANNIQSNNDIAFIDCGPCDSEHSYSTDKQLFDSSNNVTDLSNLTNTAEVGTNQNKISSMKGKISVKKFAKVPPSPVRSNNAKNANPTAACLSRVNATANHRVVTIRSTKPVNLSSIMKNFPQIADKVANKKIVFVHKNLPKNVNLTNLNDSLNNEGQNVGFFSNGSSKDQNIENQQIIQTHKLQQSDLLQTKLDSSSGGSKSKPVIKSVSQQNIKNNSKAKTKVIKKVYPPIKPKQNQKKNIQQKLDIENSNLCKASLRSSTRRILEQFFHENELMFLTIKRNEKSGKKFLSVTNNDCSTDDAFIYRTKFFSSISKMSRSKIYVRINHIKAMSRKFSEKVGFNNEIIKEHQKLISILDNIATNSDSSNQFVDDYFGPLVNASSGEICPVCHKLIKSEEYIVGFSNVVTDSDYCLCYDFICYKCNTFQGNKERLEAHLRYHNIESPFICPECNVTFSSFQSLNVHVWTECFHPLIMRFLSCNICEIGGFCSLESIINHFVIMHSVKLAACNACCMVFEYKRFCISHMKKGHSESANFNKPLLLTFCQLDDKAIPIECYNLHMQNHKCVQESYFYNCNLCSGNSKLFITKELIKTHIYKCHYSELSSFIDAASLREILLRNDIQQLFEENSTTNKLDTNLAINYESETMQSIQKLDTNDSIPELTHSSSSQIIESIKTKNINPETTNVNENNLAINLENKIIYNSKISKTSFSKTKNTTKKSNNPVDPKEDALSNDITNPKFNHNNKSSNSELSEQLNSNSSDIELMTSVDGENLITIETKNIENIIPDKPKNIDQYHYNTNNDLMETSEKTFVSSQNSKLKDKLNNTEQIQDTPLDSDLCVDSVLMESSKKAFVGSQKSKLNIATNDSQLANEENVSFSDISDDNNLHNVNCKETSETSDNIDSVRENISPLISEEWNTISRIILGSDSDKPKQINVCDSVKENNHCDTSDSLEESYETSIMEISSAHDFKDKKQCKDTTKISNNITSDCESVNLNKSIVNSIELFDVHQKEKSGNINSMNLKANNEENLKDLLAEKEIEKDYSLLTIDKDDTQNLSNCSKNNSDLLQIHQLKSDKSRESHVLTLHEESEKNGLNKMSLVPLKEQDSCVVKNSLNDKVNMQKSIEYSTLDDTSKIDESWTILNDSVSIKNNDTRLVISQTHDYIAKHNYVEIGNKSGNIENTSTSPNIVNKKKENNDNANTILQELTYECGSNNQIQKGIGSLKLTVNLQTEKTESEFMSSKTDSMTGTQSIKENLANTDNNIELQDDRMHIINQCKQILNEPVESSEIIITDMNNSNSLTNEMPTSQDIGHNEIKNTKKQTLIYEAVEEQVHDCNHVTGNEEFTNENIKSILLVNDDTAIDNETGKESLNKNTKSHVKNHHNNFPVTLPIENRNTLQCINAEQEVNIGMVDEDHVNSLIEQRSLSGSDRNEEIEESLKTNGLLVAGGSTILDQCMSLDKMNNDLKNKDKIVNTPVEKISISGRDISPEREHFEEINDSVAIAKINEVEQCNDKKCLMKQNELSGIEKFERSLIKDISELKIINQMNELSTIQENNLLEQCVVEESQSNINSSPIKDLSMHTLTEKMSVTGIKRNKHIKKVNEKFDKIHQCFVEKNQINSKSSSDNEKIEYNLIEEMLTSDKNVEYEHFEENTELETILESNELEQPFDREDQTSANSSSDNDKLEHTLIEKLPILNKDIADESTNFEEITESVNILESNEAEQLFDEINSKSLSDNEILENDLIAKVPVLDSNIIKECKNYEEIKKSVTIEKNEEIRQCINAEIQTDDKSTPDIEKVVHSFIEEIAASNQDITSEFENFEGIDDSIIIEESNKVDQCFANKEYTNQKCFKNSENIGYSTITEMYVSDQNVTEVCENIEEVIECVTTFESKLDKSFDKENQTNGESSPDNKKAENSLNEEFSASTKDITKEYDNSKNNDDLVAIEENVELDQAFDKEDQTIEHSLIEEMLKAGRAVKEFDNVEKINELEILEKGNESDQSHDAGHQIVDTNLTPEEEKIQLAVDKNLSDRGIGEENENIKINNDGMGVECVDQSIRESHVNSEQDSENISFEEKMTELEGRSNNCITSKSSIDNEEISNLTDDSFENSNLLNIDQLTVAVNHESITNNKNEAVLETAKESNNKDLIIPSSIKVKITTDKINVNTLPGRFVPEDLTSEENKMAVKDLTLKTQNSSGSSKESNKAENIKNTESADSESNEISVHKKQIYIKNNINESVDNFYLSSNVSSSAEASPAVESKIISEDSSSLDLVISVEQSIEKNAYIHEMDDSSSTDVLHDIEEKKDVIKCNEYELKNLSLTDDEKINLSKNSISLEFQVENSVVNVKRLRSRSSNRLSNSSSEVIKTKRKCKIKATTQLGKGQNLTEKNLKKSRLEKNIVNSVDTPVQENELVKTQKVEIRKTRSKSKIRRDEYLKNSNVNLDDKSVSSNAEEAKVIRRNLKRNRSENISNTDQCDKKNKLKQSLLMQMPTLRLIKTPTRSSPVDFSALPEKAPKLRAVKKYKIGFDNSTHVLNKVYKFKCHLCGDAISTSWSVVSDHYNKKHAHNYELCIISPKLTRLSDEDINRNKRKTDKKRKSSEASLANLKKRKRLSPKKVNEKIWISSDRTSGLFVQLESVIDGEGHFKCKKCDERCINMAELRQHISDSHRIAKKNLICLECGENFVVSPSLQMHLKAFHGIEDPVAYMNKYPTYAPDIDDFEADAKTTAANQCHVCMAVFKDKLSVDKHLRVHGMAFLSKKRREARNAQISKVEKFDKDQYNSSTARVSHETYRNKATPSSIADKASSSISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQR0</accession>
    <name>A0A232EQR0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002729">
        <property type="protein sequence ID" value="OXU20678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQR0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="123" mass="14869" checksum="6812AA944EE89248" modified="2017-10-25" version="1">MICVFLDKAEDLFTNKDVKQQNKEKMYLPLQVIQKQLLFLNPNYQAEKMQRKKLQHFFMICVFLDKAEDLFTNKDVKQQNKELKTHCVTQMYLPLQVIQKQLLFLNPNYQAEKMQRKKLQVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERE3</accession>
    <name>A0A232ERE3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002629">
        <property type="protein sequence ID" value="OXU20901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERE3"/>
    <dbReference type="STRING" id="543379.A0A232ERE3"/>
    <dbReference type="OrthoDB" id="1730117at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17491">
        <property type="entry name" value="MFS_MFSD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000431">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52984" checksum="C574187DC8281516" modified="2017-10-25" version="1">MDNISVETNDNQQEIQRVPLKSKLAYGVGHVLNDVCASMWFTYLLVYFHLVLGFSPAYAGVVLLIGQVADAVATPFVGLHSDKNDDFWLCRYGRRKTWHLMGTICVVATFPFIFSHCIGCSPRTHQWAQLIYYAAFVIIFQFGWASVQISHLSLIPDLTPSDLERTALTAISFTVFSNVLVYCVTWAVLHITSESPTDKIGPNDAYKFQEIVLIGMSIGVLSSIIFHIFVRENNSRDALTGVSQEESQRELQTPFSIFKDPELYQVACIYMPTRLFVNLTQTYIPLYLHETLQMPATSLAIIPLIMYLSSFKASLAINYINAKLGRKGSYLIGAVMGLGACTWIFFGKGEQFVSLFIYPVSLLLGSGGSMMIVTSLAITADYIGHSTENGAFVYGVMSFTDKLSNGLAVMIIQYMRCTTDCTDYYKQILSFVCGGAAVFGLIMTLSRNTCGNSVVRATADYSNLESEETEENPINASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERM9</accession>
    <name>A0A232ERM9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002587">
        <property type="protein sequence ID" value="OXU20982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERM9"/>
    <dbReference type="STRING" id="543379.A0A232ERM9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="72"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="525" mass="56737" checksum="D1E3FFA3CDA0F7B9" modified="2017-10-25" version="1">MLAEDDIVSAGPSQSDFSAADTEATPLLRATTSTASTSTMVEKNIGISQQTLVSNAGDRNVAAAKKLPQYMAGVAATLGALAMGMVIGWASAAGEDGKNLISEYKISMTKDEFSWITSLVTLGAAAICVPIGILSDLIGRKTAMLILVVPFTVGWLLIVFANSLGMFYIGRFITGVSGGAFCVTAPMYTAEIAENSIRGTLGSYFQLMLTVGILVSYVLGPMISMFQLSLISTVIPVIFFCVFFFMPETPIYYLKKGNLDAARASMVRLRGPHYNVEPEIQAQQEILEEAERNSVSFFEAIQGKAAIKGLVIGFGLMFFQQLSGVNAIIFYASTIFEKADESIPATTATIIVGVIQVVAVFLSTLVVDRLGRRILLLASIVAMFITTLILGVYFYLQMVVKADVSNIGWLPLLCVCTFIFLFSMGFGPIPWMMMGEIFSSTVKGIAGSSACLFNWLMAFVVTRYYLPLEKSAGAYTCFWIFSVVCAVGTLFIFFVVPETKGKTLEEIQYELGGEAPTPRRDSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESY8</accession>
    <name>A0A232ESY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA-binding protein 15B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_011839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM Spen family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002357">
        <property type="protein sequence ID" value="OXU21478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESY8"/>
    <dbReference type="STRING" id="543379.A0A232ESY8"/>
    <dbReference type="OrthoDB" id="10050565at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12308">
        <property type="entry name" value="RRM1_Spen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12309">
        <property type="entry name" value="RRM2_Spen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12310">
        <property type="entry name" value="RRM3_Spen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21544">
        <property type="entry name" value="SPOC_RBM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000112">
        <property type="entry name" value="RNA-binding motif protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000007">
        <property type="entry name" value="RNA-binding protein 15B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000565">
        <property type="entry name" value="RNA-binding protein 15B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010912">
        <property type="entry name" value="SPOC_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50917">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="303"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="384"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="9">
        <location>
            <begin position="601"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="87336" checksum="5D2091B2AEFD5428" modified="2017-10-25" version="1">MIGIPRDDRHKITVKIRNNMKRSSSRDSPPPRVKRGRSSIGRYEDSSDERITPERIRRRSRGARSPSPPPRTRYIESGSHREEYPRPPREIPAERPYSYKVLCVSGIHPKASDESVKETIYREYKKFGEFSIRIAHELDDRVAYVVFRSHEDARDAKYAKPRIPIYDKLCVVDSVYERPEAYTRRPRSVTPPDYDRYYARSPGPTDRHRPIERYDRVYGPPVGLPPRELRRDAIPPPHHDFVRPPLHHGPPHVHPGPPHHYGPPRHMMVRHPVHGFERVENKKDKFPNYLHHVQPEDDPLATRTLFAGNLEINITEEELRRIFSKYGIVDDIDIKRPPPGTGNAYAFVRFQTLDMAHRCKVELSGQYIGKFQCKIGYGKATPTTRIWVGGLGPWTSVAQLEREFDRFGAIKKIDYIKGDSNAYILYDSIDAAQAAVKEMRGFPLGGPDRRLRVDFADVTPGFGFKARPYSEDSAEFRARPAEYEAGYDPYAAESEFSYSSSRSGFRGRGSASYHEGRGGRRGAYRGTYPEGSYPREEADWPSGRRPTADADYEIPRSGRRSLSREPGVDSPRSRSPRRRHVDSDSDSENTRTGMLGTSRTLPDVARKSIAVWQGALILKNSLFPAKFHLTDGDTEIIDSLMKDEEGKHMLRITQRLRLDQPKLDDVSKRIQTSSSHAIFLGLAGSSAAITNDDANVQTRPLRNLVSYLKQKEAAGVISLLNKDTEGTGVLYAFPPCAFSTDLLKRTCPNLSEEGLKEDHLVIVVVKGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET47</accession>
    <name>A0A232ET47_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002346">
        <property type="protein sequence ID" value="OXU21497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET47"/>
    <dbReference type="STRING" id="543379.A0A232ET47"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF33">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11751" checksum="D0BAD5A7A76F8AC4" modified="2017-10-25" version="1">MIKDMADDEATQATNDDASECKRSAVQLGYWTDNFISLFVKQPNRKAPEINRGYYARVKGIEVFLDKFLKLHQLVYINKTWNKINLIRGALTWPWPNSVGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETI1</accession>
    <name>A0A232ETI1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002268">
        <property type="protein sequence ID" value="OXU21670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5814089at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="469" mass="50688" checksum="57FDF101AB9C1131" modified="2017-10-25" version="1">MSEVKINDVICSNRFSRRIRQGKIIKASASTMTMEERSSGIEDGAPVISTGATITSSNGPSNLKTKACELTTDASYPLQRTSKRSFDVAFLVAPDEKLIKRQTEKLVNLQFCTSRLKSEVSRHQEPIVTEDYNDDSREYEQNDRIPQNMTIKHFESLEASKYKIRRTEDLQAALPPYISPKRRLTPTSADLSPEPLAHLYAGSLRVQKSPSPPGIFQRTLPTRKIFVDENSSERPVDQVLGLPGPRGKSNCDSISCPDRLHGDSRSAFTKVNLAVQRSTLIGVSPSSSSVNFEEGTGSPRSSISPDVVTYQNSLSPPIAPPSNSGSAASPFNPKYTAGFPGKMPYPFLISPESQQSALLDNLKLSQQLAASSQSPPEVPSPKTPAGSGGSSSGSTNFRPELPSAVYPNLPYNPLSAVFPPIGDALARQPRFLAAGLLPXXXXXXXXPADVARRSSAVPSATRASARDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETK7</accession>
    <name>A0A232ETK7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002265">
        <property type="protein sequence ID" value="OXU21682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETK7"/>
    <dbReference type="STRING" id="543379.A0A232ETK7"/>
    <dbReference type="OrthoDB" id="440745at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF7">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU21682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="436" mass="51577" checksum="F361722436C3ACE5" modified="2017-10-25" version="1">MAEASIENDEKPIRHIGLADWHAQQWELHQSANKKESESFDLRYAAKSLISETNIKTEWNNHMNNHRLSERITELTRWHRIFDAVLDRLKNEIDLLVEERADTEKELELLDHPLQITIRCIAKRNNRTGSEITYDEGDIELKRELDLIEEMKKMMTNHIKIAWDKLNRLEDIKSKVMHELRDKSEAIKIDRENYDLSRTFPNFTYKPYALDIAENSVSYENWLEHTQHLKQLAENELGDTYTLRETMHVGKEKSKHEIEFQQDATNYALRRRAFASTKARNELEWQKLKLQKEMDTLRKRLTDLENALRAKTDDVKCAETRLENRTYRPGFELCQDEPEFGLKDELQKLHQTKEDLATKIDCAKSTLKDLDKLLERVNDALDNKKHALTTDIMCLDMRSTLIIRDGSRVQNETDRNIILTDINNELPYDTKRAFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETU0</accession>
    <name>A0A232ETU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_016841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002225">
        <property type="protein sequence ID" value="OXU21773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETU0"/>
    <dbReference type="STRING" id="543379.A0A232ETU0"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU21773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="173" mass="19857" checksum="A79C2ED49341628A" modified="2017-10-25" version="1">MATRRAIKAINWTALAERISEAERGTFAAFKSKSDQYLRRVNENPESPPKIDWAFYKSKIGIPGLVDKFQKEYEAVKIDYPADKYTPLIEAQEKEALEAVQKFISESNARIEESQKQIKKLEGMLKYSQMTMEDFKDAHPEIALDPLNNPTIFPHTPEYQPDPEGTEKPAVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUB4</accession>
    <name>A0A232EUB4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002138">
        <property type="protein sequence ID" value="OXU21960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUB4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850585" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9338" checksum="6B2974B8197676E4" modified="2017-10-25" version="1">MLTVQLFLSLRFFRVFLFDVRVLNDEEPSCSNGCQEENKIFRFISLPRNLKELIMQKQKKKNYLTPTNHQKNDIRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUR6</accession>
    <name>A0A232EUR6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centriolar and ciliogenesis-associated protein HYLS1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HYLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002098">
        <property type="protein sequence ID" value="OXU22092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUR6"/>
    <dbReference type="OrthoDB" id="6343432at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052319">
        <property type="entry name" value="Centriolar_ciliogenesis_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027918">
        <property type="entry name" value="HYLS1_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34174:SF1">
        <property type="entry name" value="CENTRIOLAR AND CILIOGENESIS-ASSOCIATED PROTEIN HYLS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34174">
        <property type="entry name" value="HYDROLETHALUS SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15311">
        <property type="entry name" value="HYLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centriolar and ciliogenesis-associated protein HYLS1 C-terminal" evidence="9">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="320" mass="36912" checksum="5CAF33B2D7E0F1C5" modified="2017-10-25" version="1">MEEETYDDPKQVLVILNSLGVVGVTTSELKAFMKELKAYKKVKRKMCQQSKDKIKMKILQKQDPDKIFQVYNSRQSLIEKTLKRQEKEFNSRQTSIETTLKRQEQEFNSRQTSIEKTLKRQEQDFTPRHNSISMAQNGTEIHASSKQSSEFANKENNVENRIIISLENLKCSKGKSPHKKTPMKLTREQKEADEIHSVRTCGSVKKILVEPASSKSKKPGMPVSSRSDNTESCSRSKSFIRPQIPCTESKSSLSSKKMATDPVTLYKKYKDFWDQLSIPGEENHTKLRWSVREKMLGQHPVPKVKNLFNLFHLTNVIINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV91</accession>
    <name>A0A232EV91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_012679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002029">
        <property type="protein sequence ID" value="OXU22269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV91"/>
    <dbReference type="STRING" id="543379.A0A232EV91"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21065">
        <property type="entry name" value="NURR_Syncrip-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12250">
        <property type="entry name" value="RRM2_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12251">
        <property type="entry name" value="RRM3_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000175">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000024">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000213">
        <property type="entry name" value="Uncharacterized protein, isoform R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041337">
        <property type="entry name" value="hnRNP_Q_AcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18360">
        <property type="entry name" value="hnRNP_Q_AcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="292"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="387"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="699" mass="78601" checksum="A68F6377A109FF3C" modified="2017-10-25" version="1" fragment="single">MAEGNGEIKAEDKQSKEEMEYVERTEDYSKLIQYGLNEKVAGKLDEIYKTGKLAHVDLDERALDALKEFPVDGALNVLTQFLESNLEHVSNKSAYLCGVMKTYRQKSRAGQGTGNTSTTPKAPDEDKIKMILERTGYPLDVTTGQRKYGGPPPNWEGPTPGTGCEVFCGKIPKDMYEDELIPLFEKCGKIWDLRLMMDPMTGTNRGYAFITFTNRDAAQQAVRELDNYEIKPGKSLKVNISVPNLRLFVGNIPKSKGKEEILDEFGKLTGKLNDYEIRKGKKIGVTVSYNNHRLFVGNIPKNRDRDDLFEEFTKHAPGLTEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRMKVWGCDIIVDWADPQEEPDEQTMSKVRVLYVRNLTQDCSEEKLKECFEQYGKIERVKKIKDYAFIHFEERECAVKAMRELNGKEMGGSHIEVSLAKPPSDKKKKEEMLRARERRMMQMVQMMQSRGGYDNALGSPSHPGMMGGPMPVRGPGQGPRGTGAGMRGPLARNDTYDYDYDYYGYGDYRGGYSEPYYDDYYRYEDFFFDYAPPPPPARGRGRQPQPNNWQEPIKKQKVGKRKFDGGHQNQGESKRRFQSSWGNQPLAQQPLGNAYAMASVNGGGGGGGGSGGGNNTGGGNSANERSNSGGGNNSAQADDEWYQDSIPLLHCHVRFKNDTAKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVK3</accession>
    <name>A0A232EVK3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_007735</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001988">
        <property type="protein sequence ID" value="OXU22377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVK3"/>
    <dbReference type="STRING" id="543379.A0A232EVK3"/>
    <dbReference type="OrthoDB" id="2413561at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000189">
        <property type="entry name" value="Neogenin isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280158" evidence="15">
        <location>
            <begin position="26"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="139"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="325"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="414"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="519"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="604"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="827"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="748"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="976"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="980"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="981"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU22377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119470" checksum="2BA17C2CE21B13E9" modified="2017-10-25" version="1" fragment="single">MQRHQRVRLVLTIGFLLAGCRSSSSQERLQQMQPGELYFTVNPSDHQVIEGQSVTLRCEAEPGAPVRYSWKIDGQPLAPSPRRHLRNGNLVISRVNRMLDSGSFVCVATNEKSGDSIESSPAKIDIQWISEASVQLQQPKLAPNIRAGGKVELRCHVDGSGELKYEWFRNTKSLAPNDRVEMKRNLLLIQEASPEDNGVYRCLARNQAGASPLAHTYPLIVPSNETATIKLVPQKAIVRRYEPASFSCVFDNADNVQWFFEDKGPIESDDERSILDNGTLVVLKAEDRHKGYYACHGLRADTVQVYAAELQIAYLYNLTSESFEPPLENQLAVVGENQELQVSCLAPGGLPTPKLFWREPQGRIVSDTGPVRVQDDTLILAKARRNADEGNYTCHAENMAGATHATVRIIVSWPAELRGSPKPVSVMEDEPATLTCSFRAMEPPITQVRWLRDGEALLSKDGVRYRIVEEPAGNLSLVFKNVQLMDRGNYVCEIVTKGFSPVRSAPAALSVEEKLKFSPEPVNRKLELNSSPKISCKAQGSTPVTFKWYKNGADSFPKHVRDELNGTLHFNGVLEEDKGNYTCVASNSQGQIKHTIKIDVVISPKFTIKPENATAIEGSSVLLHCAAEGDPKPAIQWDKDSRMNNLNGDRFEVMANGSLHIKEVYLSDEGKYGCTAGNSAGLKREEGHLSVRAGDGYRSDMELDAAEDGSMMTKTVIITLGAAAAYMVLVVGLMLYCRYRRRRRKQRYLQEQTDGQEKGEATEVQEEQCNLTETTASAKANSSSGKRKENRESHKSDGTDTAHSQNSNHSKKSKSSYDKLAVSRAHLQELKPLGRGEFGEVFSTKYRPHASTADETSTTLKESVVMVKTLTNTKDENVLQEFKRHLDLLHKLNHEHVARLIGLCRDEEPDYMIIEYTDWGDLKTFLLASKSKETADSTDAAKPRAPQLTVAQILSLANQAARGLKHISDHRLVHKDVAARNCLISSALHVKISLSCMTKEPHQQEYTKHKNQIIPLRWMPKEAVFEDEYSTKSDVYSYSCLVWEMFQQGELPFKKLNDESVLNQLKNQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWA6</accession>
    <name>A0A232EWA6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001902">
        <property type="protein sequence ID" value="OXU22611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWA6"/>
    <dbReference type="OrthoDB" id="7701443at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12645" checksum="ECC3DAED4E58D066" modified="2017-10-25" version="1">MRESLLSDHPEDGKVKLISGSKIYTNKTELKLLKMQYRSKPEQFARRLIKSIVGEDELESMTPDGDELIAYLCQFTMPFLVIYVNKKIPPDVNRMLESRYQHVLQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX25</accession>
    <name>A0A232EX25_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_016450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001794">
        <property type="protein sequence ID" value="OXU22901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX25"/>
    <dbReference type="STRING" id="543379.A0A232EX25"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011824625" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="593" mass="68404" checksum="C1BD6611156285EB" modified="2017-10-25" version="1">MCRRFILGFLAAVCLQLICVQADEHNHIYEKGDEVVLWMSTVGPYHNRQETYSYYSLPFCKGPKEVISHYHETLSEALQGIELKMSGLNIEFKDPVKKQEYCSVKLNEESYKAFVYAVKNQYWYQMYIDNLPIWGVVGEPDEINNNNGETSYYIWTHKKLDIGYNGKQIVDVNLTSESKVELKVGRTIPFSYEVNWKKSNTKFEDRFDKYLDPNFFQHRNHYMTIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKDEEMDDMERDLGDEYGWKQVHGDVFRPANHPMLFSALIGAGYQVTVVVLSVIIFAILGELYTERGSMLSTAIFVYAVTSPINGYTGGGLYARMGGRVWIKQMLLSAFMIPALVCGTAFFINFIAMYYHASRAIPFGSMVAVTCICIFVILPLTLVGTILGRNLAGTPDAPCRVNAVPRPIPEKKWFMEPLVIIMLGGILPFGSIFIEMYFIFTSFWAYKIYYVYGFMLLVFVILMIVTVCVTIVCTYFLLNAEDYRWQWTSFLAAGSTASYVYLYSFYYFFFKTKMYGLFQTAFYFGYMALFSLALGIMCGTVGYIGTSLFVRKIYSTVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXK3</accession>
    <name>A0A232EXK3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001737">
        <property type="protein sequence ID" value="OXU23075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXK3"/>
    <dbReference type="STRING" id="543379.A0A232EXK3"/>
    <dbReference type="OrthoDB" id="8182951at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17711" checksum="3FFB3630156C2D38" modified="2017-10-25" version="1">MGTAENVDVLGIRRKCPSYTFPERLPVKRCSKDEDCEGLNRICCPDKKDRLLYCRTAAPIWSELPFPENIDTLKTLVGFVQCQPAPPSIIDIFARPCNRTLDCVPNLCCQEGSKKICRPPKRSVLSLAVQATTVSLVLDILAIFSMSANDLTLFFAETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXL8</accession>
    <name>A0A232EXL8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001734">
        <property type="protein sequence ID" value="OXU23085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXL8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="291" mass="32548" checksum="648803A175C043D1" modified="2017-10-25" version="1">MSGYVVYLAPPEPETTTTNDVVVEDPPPSYEEVCGIGSVTRVTPASNHQNPNGNDESIAIPINYQLPSTAIFEVEPILNPADTRNDANCSRSDDSRILRPRRLTAIVRGSLRFEQQKICNMCHTANDIVSSRKSNSSANFGATETWSNSDTSTIKGYINIAQCTSHLRRGMSEHVVRLEAASEDRHDEVEDPPPSYEEVCGPKSQTESRRDSTTRVTLLQVPGGNNAEDDRQRRSPDAEQQPRYRVTILARAQPMGNCDFCKCFFNCLVFAIIIVVIWFLTLSAKHRNRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYQ4</accession>
    <name>A0A232EYQ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DnaJ homolog l(2)tid, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein lethal(2)tumorous imaginal discs</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_009323</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001615">
        <property type="protein sequence ID" value="OXU23417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYQ4"/>
    <dbReference type="STRING" id="543379.A0A232EYQ4"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000003">
        <property type="entry name" value="dnaJ homolog subfamily A member 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000075">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="18">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="19">
        <location>
            <begin position="239"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="16">
        <location>
            <begin position="239"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU23417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="522" mass="58016" checksum="87892B393FA0758A" modified="2017-10-25" version="1">MRLSANMATGKGLAAILRPRNLSLIPRGKPQNGQNQASSRCSDCRRHYATGPMPVDSWSGSFKVHKYTAAGSVQIHRKFHLTSETLAKKSYYEVLGISRNSSAKDIKKAYYQLAKKYHPDTNKDDPNASKKFQEVSEAYEVLSDETKRKEYDTWGATSEQMGMGAGPPPGAGRNQDTRDFNWQFKSTINPEELFRKIFGEAGFKSSGFSDFEDYADSRYGFGAAQEVIMNLTFSQAARGINKDININVVDTCPKCQGSRCELGYKAIKCHYCNGTGMETISTGPFVMRSTCRQCHGTRVYIKHPCGECEGKGQCVQRKKVTVPVPAGVEDGQTVRMAVGNKEIFITFRVEKSKYFRRDGPDIHTDADVSISQAILGGTIRIEGVYEVLTVQIRPGTSSHTLIRLNGKGLKKVNTVGYGDHYVQIKIKTPTSLNEKQRALIQAYAELESDTPGSIHGITTKKDGTKQCYSEPFDLMESIREALTDQKIQTKTKSSTPSNPADKPQDVSDDDDHDEKSERQKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ91</accession>
    <name>A0A232EZ91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001550">
        <property type="protein sequence ID" value="OXU23629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ91"/>
    <dbReference type="STRING" id="543379.A0A232EZ91"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="33120" checksum="8B379943196FC9EA" modified="2017-10-25" version="1">MKCRAYHVTPSFEWEKKNDRYTMRYDLENGKEIAKCKFPNKKFDLKFPEKENIVQIFTDGSKMKKGSITHVGFATWSKMDEFNFTCTINDIASIYTAECKALSYLIDNITNKNYSEFVIFSDSKKNEKILINLSKNKGTFYFEHFYVNKNKPWFYNTGLSRKSTVSINRIRCDHNSLNSNLYRHKIVDSDLCKCGEDADTVEHIFWCCKLSKSERETLLKEIRKEYKIGPYSVINLLALSNVRILNTISEFIDKIDCKIKNFNHAKPRSNSEKVPCDTVFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZD9</accession>
    <name>A0A232EZD9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_005485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001483">
        <property type="protein sequence ID" value="OXU23812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZD9"/>
    <dbReference type="STRING" id="543379.A0A232EZD9"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="369" mass="43613" checksum="A88EE0EAD30CCAF7" modified="2017-10-25" version="1">MRAIKFPAIIVLIECAIRSAGFSYPQLKLLSVVRNIRYNMCNPSEVFRHGDREINDEIGGDLTQVGRLRAYRLGEILRVRYGDFLGEEYEPSRLYARSTEYIRAKMSLQLLLAGLFVPREQQRWHESLDWQPIPFSYARSKEDVLLFPRDCPSFQREMKRFIPSPGFQKLLDPYREMMRNVTIWTGQEMSIPNHMFVLYHKLSSMQALDEPLPKWSRDFFPYGLLLNGTYLEYDTHKYTDWMRRVNGGTLVRKIIDDMLNRTDEKYPRKRDVYLYSGHELNVVSILQSLKIWQPHIPEYSSAVIVELREDRKNYYVKVLYHKGIPPIFKEMQIPGCPSLCPLDRFIELLSDNLPAYDEIICDDKTVKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZE6</accession>
    <name>A0A232EZE6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001549">
        <property type="protein sequence ID" value="OXU23630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EZE6"/>
    <dbReference type="OrthoDB" id="10040649at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031866">
        <property type="entry name" value="DUF4758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39072:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39072">
        <property type="entry name" value="RE48511P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15950">
        <property type="entry name" value="DUF4758"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257645" description="EGF-like domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="5520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5104"/>
            <end position="5129"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="5011"/>
            <end position="5052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1355"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1765"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2189"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2521"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2578"/>
            <end position="2701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2716"/>
            <end position="2741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2753"/>
            <end position="2772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2786"/>
            <end position="2817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3319"/>
            <end position="3370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3401"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3571"/>
            <end position="3600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3614"/>
            <end position="3649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3904"/>
            <end position="3948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4031"/>
            <end position="4096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4164"/>
            <end position="4377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="5174"/>
            <end position="5208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="5372"/>
            <end position="5391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1382"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1420"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1462"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1542"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1563"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1574"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1625"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1639"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1658"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1685"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1765"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1813"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1836"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1856"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1884"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2192"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2587"/>
            <end position="2598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2607"/>
            <end position="2624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2625"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2658"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2728"/>
            <end position="2741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2753"/>
            <end position="2767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2801"/>
            <end position="2815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3321"/>
            <end position="3331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3410"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3578"/>
            <end position="3599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3630"/>
            <end position="3640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="4058"/>
            <end position="4072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="4073"/>
            <end position="4082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="4177"/>
            <end position="4202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="4317"/>
            <end position="4326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="4327"/>
            <end position="4339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="5174"/>
            <end position="5188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU23630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="5520" mass="604387" checksum="EDD1966521773212" modified="2017-10-25" version="1">[encoded data, 5520 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZU3</accession>
    <name>A0A232EZU3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001452">
        <property type="protein sequence ID" value="OXU23931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZU3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="9711" checksum="AD8B451299113A9B" modified="2017-10-25" version="1">MSTASQQPPTPPVTFELIVSGVPNDINPELRKIASLFLRVLQLPHLETDVFTSEAFPRSRTLHSSTLPLNPASSSVIFSNDMHLAAQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZW2</accession>
    <name>A0A232EZW2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_015812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001457">
        <property type="protein sequence ID" value="OXU23915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF42">
        <property type="entry name" value="ODORANT RECEPTOR 83A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1253"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1343"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1385"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1599" mass="182036" checksum="5A8764913E983392" modified="2017-10-25" version="1" fragment="single">TKGVVEVDSIFVMVMAVSTIMRYYILVYHRFDFRDTMDACRVIWNDCTPNEHQIVRWFERKTWMLFKLLAGSGMFINVFCSIGSIVVRLPPDEPNGTERRLLPYRWFIEDREYHWLGYELIFGLQVLITHHLTVIAATVDTAGPLLMMISCGFFKALQERFFAAAAKNEMILCIDKLEFKRTIVSCSKFHQSVLALCKKIEVMTRMIFMVQLMCLGYNISLIGLKLTGVRHILHSPSASTILISLLKHRNSTAQTDPERFQYIPNLVLCLCQLFITQWASDYLLEQSEEVATATYFATLMSLDARIGGLLLIMVTRAQKPVQMTAGGVIKLSIERFGNLRHLDVSVTIRSSFLKDYIATTIMTKSEKSLSFKSLTAVFVFFHRLIGVLPLENRDFNFPSCQMLLLYFMFIGLLISVMFLRYCITRLIQGSVELDSVFVTVMATSTIVRYYILVYHRFEFRDAIDACRDIWDDCTPNEHQIVRWFERKSWILFKLLAGSGLLINVFCSIGSIVVRLPPDEPNGTERRMLPYKWFIEDREYYWMGYELIFGLQVLILHHLTVITATVDTAGPLLMLLSCGFFKALQERFFAAAVSKEKFLIEDELRYQPLLTSCSKFHQNVLNLCRKIEVIMRMIFMVQLMCLGYNISLIGLKLAGNDPERFQYIPNLVLCLCQLFITQWAADYLLEQSEGVATAAYFTTLMSLDPRIGGLLLTVITRAQKPVQITAGGVINLSVERFGNLITNAISFFMVLRINSNIMSEKSRQDECGKLHVFLLKLIGLLSFDGRSLNFPGTVLLSIYVHCSHLLVTSMYVCNVAKTGLGDGEYDIETVAETVGLCGVHFRFLIMFFNRKRIAKLLNESKKLWTELDEFEVAIIRSFVEKSLRLTHFYLGANGVMCAFYLTVSQFSVHNSLNSTFTRSLPYPFYADVQSTPWYELSVTGQMLGMIGICLSSSGVDTAAPFFIMVACGHHRSLCDRLQNLASAVDDDDQVAKVDAVKKIIECIVYHQRMIKFCKEVEKLTNSLFMVQLISTTYNMSLIGLKLVGDDPEKLKYLTVLSLLMCQLFMCQWAPDLLVSESESLARSAYFVPGSGDESKKLAKLIHILMMRSQRPLQLTAGGWINLSMECFGSMITSAMSFFTIVHRTSLYLRTRRTIYPLSAFAATTEHNSRRGIKFTSRRRKKKLVKYSSSTPTLSGNATQRTQYELGTYRSLIYTAMSSSRASKSFNASSRIQLSLFRLIGVLSFEKSRPLTSRLLSGWFYLCYCFFGSMFLNTCVHNCLRGYYNLEQISETVILLGSVGRFLLLIGSRREMERLLTSAEDLWRVLEQGERTLVARFADISRKVVYAYLAASCLMCSFYIGITPILQGNATWRVLPFEFYVEVQSTPWYELVLILEGIAMFSLALVSSLVDITAGPYLILMGCGHLRTLGHRLRNIDSRLDGRSAASSRQYLAELTSCIRYHQMIFSYCDQVQRVLGGVFVTQLISTTYNISLLGLKVIGSDPDKSKYVMLIGVLMLQLLFLQWAPDLLVEESKRLASDSFLVPPIGRENRQIGQLICIFAMRSQRPIEMKAAGYLELSMESFGAMLTNILSFFTVLHSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZX7</accession>
    <name>A0A232EZX7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001516">
        <property type="protein sequence ID" value="OXU23718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZX7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="44" mass="5136" checksum="D54C334139EFF7ED" modified="2017-10-25" version="1">MYLHKRYRSVRTRRFAAAVVQFFLLLSISCLYSRGSTVLQLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0S6</accession>
    <name>A0A232F0S6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Progestin and adipoQ receptor family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_015758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001381">
        <property type="protein sequence ID" value="OXU24169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0S6"/>
    <dbReference type="STRING" id="543379.A0A232F0S6"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47908" checksum="7E5F4FA6A3673CBA" modified="2017-10-25" version="1">MSRRGVRSPTALQMMKILPCVEEVTDAPRDDIVNEHLVHNNNAHEKPKPLEEMEEKPHGHHPTMFDRPRELADSPIKGPVTPEDEQRMRVLLPYHLAPEYLRFNPFILTGYRGYLTTKLCIESIFWWTNETINIWSHIFGFVLFCGLTFYDLYLVNITAPFGDKVLCALLLVCFQACMILSSIYHTFSCRSEKDYWYFLSYDLLGVALSLLAIYMSGVYYAFWCHKGLQRFYLVTVLAIFIVAMLLQLPRYQVNDNIKLAVFVGWAVYGVLPTLHWVVAMGGMQNPVVNLLLPRVLGMYVISGAAFLIYFSKMPERLFPGCVDYLGSSHQWWHILVVAALYYWHNTGMMYVEYRLNNGCPSLTPAVFSMECACEMENRWSSWYQESVIPYYAQQGVLTCLIENPLRAYAQLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0X2</accession>
    <name>A0A232F0X2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_015712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001402">
        <property type="protein sequence ID" value="OXU24097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0X2"/>
    <dbReference type="STRING" id="543379.A0A232F0X2"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01211">
        <property type="entry name" value="PTB_Rab6GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="559"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1004"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="808"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="936"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118701" checksum="BCB5FE18F5A4F651" modified="2017-10-25" version="1">MEDSMSVKSTESVATSDEYEFVSEKETIKQSQSLLESPMLKIANNGNLEDLQNNLHEVLTEESKMNEDTELKIIPSNVSNIQKTKTIGQSKFYDVTSSCAVTPEKQDEEKPDDYIEEELCILSDVQQEYTKFDAVTYLGSAQINAPKSEAEIQRNMKILAEQSTVPIKVSISVPSCSQGSVILYDSANQQPIKSYEVQRILFYARGESTGSCAACFAFTWSHGDTQESAIFQCLAFRCDIPEAIRQVSSCFAKAFQRFPRSMTNSLTGSDFNNGFNPVSDKVNSRVFIFEVTMEIKEEDGKGAYNTVPKDRNCFKLRSNVPKQVWLNIQQVKEGGITLEIERCFGVLVSPGRNVKHSDMRLLEMQISSSPMVSDKQSYNVCGKWDPADPALETLNIETEGKIFMTVAVDLVIRGIREPVRFVIETSVKVFQQNERFWSFYKKNLIQQFFLNSKEIISNEGNEIHYEVQNIETSGEIDRNRLNLALNLASLIRSPSLTSIDTLTPKEDFDSDGDEPMLSGTGEVSKDCSADELASWAEVLDSWQVNEQRPKLLVKLARQGIPEALRGEVWQRLSNCDNSQEMMDKYRMLITKESSCEGVILRDINRTFPAHDFFKETGGLGQDSLYRISKAYAVYDEEIGYCQGLSFLVASLLLHMPEEQAFCVLVKLMYDYGLRDLYKDRFDNLHMRFYQLNRLMEDQLPELYKHFCDRGIETHMFAAQWFLTLFTARFPLYLVFHILDVFLLQGLDTLFQVALALLTLCKKELLQLDFESTLKYFRVHLPKRCRSEEVSRYVMKLACSITLKKLKKYEAEFMALKEAQENADEYSNEVEQLRGIVARTEEEKQRLELELAQVKEMLQREVNRADVESRRNNVIITEYKQICQRLEDDYNTANASLSELRTKVSKCDKCASTALDSSGAASNATSHPLENRVDPILSRAQERVRELELELAQTKLAHVEAECRNQDLTHQLHATSAELNAARNSWPWLSKTLSSIKEAANKREMTAGGAGGGSVAGILRRESAPSGEMRHALHSQNRDSFKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1M2</accession>
    <name>A0A232F1M2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001251">
        <property type="protein sequence ID" value="OXU24614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1M2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29324" checksum="E875071843389CBA" modified="2017-10-25" version="1">MIRSRPWFTLYKYKGLQHLTERTDSKKYVLAACLKCDVDNVSLRTGYPEVKKSRKLISTARKSNSKCKVKVSDKKVVKQKVKRKCYTPEAIKNTVKVVNEGLSPRKAGVMYSVPHVTMFRRLKNPNAKTSGPPTVLTSQEENDRETIELAPETTNQLHTVDNGILREIIKPTNQRSIISEEEATKEKSRKPKRIFKSQEPEKLPVVGTSEEWLRIQAEKEQEKKIKEEKLAKKKELQEKKKQLAEEKRGYRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1P2</accession>
    <name>A0A232F1P2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001293">
        <property type="protein sequence ID" value="OXU24462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1P2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="12460" checksum="CA92ED2E2B00E64B" modified="2017-10-25" version="1">MRCTEKRFVLCLRAKFCLVKKKNYIRRRYLNSCNDMSLLHCQDIIEGPLDALTAAKQSLNHHRLIIRGKYPSLHTFYKRKSINCFQGSYRRMKFNLFDLYFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1Z3</accession>
    <name>A0A232F1Z3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the parvin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001275">
        <property type="protein sequence ID" value="OXU24530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1Z3"/>
    <dbReference type="STRING" id="543379.A0A232F1Z3"/>
    <dbReference type="OrthoDB" id="2099265at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071963">
        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21304">
        <property type="entry name" value="CH_PARVA_B_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21306">
        <property type="entry name" value="CH_PARVA_B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000015">
        <property type="entry name" value="Parvin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000011">
        <property type="entry name" value="Parvin, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="179"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="345"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="455" mass="51092" checksum="F4D49A3D8C896318" modified="2017-10-25" version="1">MDQEIENEKVSPQVAQYMSSILTANQPDDDDDLLEDSCPQVVGVLCKKRQSGGSQDKNDALLQDSDEAAADKNVNHELNSVGLIAGLAVMASPRPKSPRPAPISAKKEDKEESFWDKIGTLGRKKRIKEVQEVQEEGKYAIDSPGFAALVDMPPEDYALDENEERSMIAPRSLDVPKVQELIHVLIEWINDELAEQRIIVKDITEDLYDGQVLQKLLEKLTGKKLDVPEVTQSEEGQRQKLAVVLNTANRILGCYPPYKWSVESIHSRNIVAILHLLVSLARLFRAPVRLPELVSVQVVVVTKKDGQLIHKTVKEEITSTYDDLGMRCERDAFDALFDYAPDKLAVVKKSLVTFVNKHLSKVHLEVTDLDTQFHDGVFLTLLLGLLEGFFVPLGSFHLTPKTHEQKVHNVSFAFELMQDVGLPKPKARPEDIVNLDLKSTLRVLYNLFSKYKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2B7</accession>
    <name>A0A232F2B7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01001176">
        <property type="protein sequence ID" value="OXU24861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2B7"/>
    <dbReference type="STRING" id="543379.A0A232F2B7"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09093">
        <property type="entry name" value="INPP5c_INPP5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000132">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase OCRL-1 isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000012">
        <property type="entry name" value="Putative inositol polyphosphate 5-phosphatase OCRL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000004">
        <property type="entry name" value="Type II inositol 1,4,5-trisphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031896">
        <property type="entry name" value="INPP5B_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037793">
        <property type="entry name" value="OCRL1/INPP5B_INPP5c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16776">
        <property type="entry name" value="INPP5B_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="10">
        <location>
            <begin position="681"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="874" mass="99595" checksum="6F63D8292B3180BC" modified="2017-10-25" version="1">MSTPEQLAIVQSKFTTEEEKACIFLNLFLKAMEAMLIQGWLKTTRLIALVNKGSTNALVILITSRTPPQVYSDLSIERILPIDQDFQCDIGTDEEQKDITDVFLNVTCRKSRTIFEMRPGITTTNLVSAIFQAIDVYQKNKNPTTDFLWIQKLTGSVRSLDNTSDPVQSTTEPVIELESPDLVVSRRNIATGKTPIATRESVVRYQMACKEDDYTYTKVLRIFIGTWNVNGQPPNGITLEQWLSSDEVPPDLYAIGFQELDLSKEAFLFNDTPREDEWRQVVAKSLHPKAVYEQVALVRLVGMMLIIFAKTSHVPHIKNVCIDTVGTGIMGKLGNKGGVAVSCCIHNTSVCFVNAHLAAHCEEYERRNQDYADICSRLNFQTYVPPKGFKDHDQIYWLGDLNYRITEMDGHTAKQLIAAGNLDPILALDQLEQQRRLGRVFYGFHEADIKFKPTYKYDPGTDNWDSSEKGRAPAWCDRVLWKGEPITSLEYRSHPELKISDHKPVSSIFDSKVRVIDVVKYRKIHEELMKKLDKLENEFLPQVTVDTTEIIYETLRFDEPCVKELIVANTGQVPVEFEFIKKLDDSSYCKEWLTITPYTDFIEPGQKCDIKLEVCVDKRSAWKLNSGEDKLYDILVLHLINGKDIFITVTGTYERSCFGCSMEALVHIPVPIREIPIGRIMELENNKNVSQDPYSVPKEVWLLVDRLYRHGIKTAGLFETQGLHSEVLAIRDWLDIGSQDPMPGSVHSVAEALLLLLDSTPEPLVPYNLHNVCLSAATNYLQCKQIVMQLPEIRRTVFLYICSFLQELLNHTQDNGLDAKTLASLFGAFFLRDPPRSRGDRNQRSKTTQVTFDRKKAAFVYHFLINDQSDFIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2H7</accession>
    <name>A0A232F2H7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001245">
        <property type="protein sequence ID" value="OXU24617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2H7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="113" mass="13287" checksum="7A05C3EDC4E23767" modified="2017-10-25" version="1">MENINNNNNNRENNELSEKILNDHLFKSNPIVMILHEGEENIYNNAPAKRAKKRFQIFNKFIRSISESFYIIIYKFIEVISLISNAVSHIRIYVYLYGLYGSRGSRDFPIVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F303</accession>
    <name>A0A232F303_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcyclin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_000903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001120">
        <property type="protein sequence ID" value="OXU25065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F303"/>
    <dbReference type="STRING" id="543379.A0A232F303"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000006">
        <property type="entry name" value="calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037201">
        <property type="entry name" value="CacyBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015120">
        <property type="entry name" value="Siah-Interact_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09032">
        <property type="entry name" value="Siah-Interact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140106">
        <property type="entry name" value="Calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CS" evidence="12">
        <location>
            <begin position="71"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="11">
        <location>
            <begin position="149"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU25065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="228" mass="26000" checksum="0E011F1E453D5C66" modified="2017-10-25" version="1">MTARINEIKMDIDDLNSLLDKASRQKSKDVLNLEIRRLQTELFNLQSQISTNQENKASKPIANSALKCYDIKLNNYAWDQTEDFIKIYVTLNNVQSLPKESVFCNFSDRSMDLHVRGLDNKNYELPINNLCEDINTSKSFYKVKTDMIIVSLAKKSKKNWTCITSVEKRIKAAKATPSVSDPSDPNASLMSLMKKMYEDGDDEMKKTIAKAWTENQDKKTSLGGLPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F343</accession>
    <name>A0A232F343_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_006219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001167">
        <property type="protein sequence ID" value="OXU24908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F343"/>
    <dbReference type="STRING" id="543379.A0A232F343"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="360" mass="41469" checksum="91F38C7FAA5A5235" modified="2017-10-25" version="1">MSDIIDIGFAEECESWRLASRFFPSKIGGKPAWLDLKNIPDATQLACEYCGNPCMFLCQVYAPYEEDDKAFHRTLYVFICKNADCCKENCNGNIKVLRSQLKRVNEFYPPDPPIEEKNWRTDICTEKWSKTCSICGIFSSSHCAKCKQVNYCCRLHQVWDWKNSHKNLCGKEQSSENEKFLFPQFELVTEKEEYNPSNEDSVTSEEELQKFEELVKTGQAGTLQSEKDIDDDLLKMASGIEDKTFSKFRKRIKGEPEQVLRYNRGGSPLFISSSHQPESIPKCEECGGDRQFEFQIMPQLLVYLKVDNILESIDWGILAVYTCKNSCTPKTKYVQEYVCKQDIIKENSMDSPNADQSNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F389</accession>
    <name>A0A232F389_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015993</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001077">
        <property type="protein sequence ID" value="OXU25224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F389"/>
    <dbReference type="STRING" id="543379.A0A232F389"/>
    <dbReference type="OrthoDB" id="536093at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042815">
        <property type="entry name" value="DRC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="233"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="444" mass="52444" checksum="89BFA1FB0A971B42" modified="2017-10-25" version="1">MFKKNSLNFTPEMFKLNSNFYLDQGFFEKESHFEKPSEISNFEVTVFLNRLIGVFDVLMTKLEFAVNLRKLLLKHSKMATLPFILSHPRVLEILKAQDLKQIVSAFVPFSYFRNSSEETSLLHSLEESDLKTSESSVEVKTQNDKDCNCLHASFELCGSVKDNASVYSAVHILHSYPLIRQLAKDSQNDILKSTLNFLRQIKYLMEFVISKVELLPVEERDRELHIRHVCSEIEQSKHEISELTKSLEDQKIRHRTEANELSDQVTILMETWRSINDEFNSQLTKTLKDSEDNLAKSLSEFNERMENHQSTLDKLKMKVENQKAENRKKEHEVQGKKFKVESQLSSLIMKFDTEVSDRQQYYEELMKEYDALEKERLQLMDDMDKQLNIYDNIVEEKEEKEFAAYKEKYTNFVNNRCAKLIQRWWRNVCAKKKKGKKKKKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3T2</accession>
    <name>A0A232F3T2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_009543</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001103">
        <property type="protein sequence ID" value="OXU25130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3T2"/>
    <dbReference type="STRING" id="543379.A0A232F3T2"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19578">
        <property type="entry name" value="serpinK_insect_SRPN2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000030">
        <property type="entry name" value="Serpin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF357">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="11">
        <location>
            <begin position="250"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="11">
        <location>
            <begin position="657"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112797" checksum="E707687C0C2AEA2E" modified="2017-10-25" version="1" fragment="single">FTDKEVLGLSIDRRSGEPIRHQYSSLTSRRTNAMSSKTLVLVILASLALSQAIAIGKPTNQLEGTTTRVVKANANDGFTLQSGFEGYVASPQKTAVSSSGSSFKWIATTLAKLKLLKSLLIPISGALLVYGVKIVAHLGLSMLLGVVATTAVCAFTPICSFSLSLPGLDIFKGKSVKERVAEYARDYMTKENMEMLSLIVQSALNKYGTGQLREEEQPATESTTTPNGTSQDEIDDFVPYQGERSNIFDWNLLQNLAKSNRGNLLVSPISLKLALVLLYEGAQDETAQQLATVMHLPVGILATRDKFSSVLKSLQTRRPEYALNVGTRIFLDQSITPRQRYGAILKTFYNTDIVSLNFGNAKTSAELINDYVRNVTQARVQKLVEDESKLRNSMMLIASAMYFQGTWLRQPFSVNQTQIGKFRLGDGKNTVQVPFMRSNGKFYYAYSSDLEAKILRLPYAGRKLAMYAILPQAPGKLDELVKKVSPFVINRHVWLMQELYVDVMLPKFKFDFTSKLENNLRELGIRDIFDDTATLTGILRSKSTSRRLVVTDVIQKTGIEVSERGTVAYAATEIDIGNKMNDETFQADQPFLFYIEDESTGTILYMGLVNNPLEETGISESSAAPQMPSRVGGHEDAPTAPSAIGTGVDERQNFFNVELLQELNEAKPGNVVIGTSSVKAALMILAEAAGGRTRQQIVSTLRLPSDVAQIRDVVSQSISSFKDPKSNTVLQTAIKMWLSKDVALHKDYTDILQRYYKGELQATNFADVAGTVKTINDWAKKCTNGHISSILEPNSVAADTKMVLTTAVYFKGTWLHSFDKTATRSRCFNVPKLGCQQVPLMEVVENYKYNYVPALDAQVIQIPYTGERVSMVVLLPQRLGEQALLDLSRDLAFTPVSVLLSSLQKTEVLLQLPRFGIGNKVDLRATLEKLGIKDLFDENANLTTAFPRGNVQVGAVMHNAQIQVNEEGTIAAAVSGVSVIPLMGSTVTTFRADRPFLFFLVDHQTNSILFAGRYVQPEGTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3W2</accession>
    <name>A0A232F3W2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_015704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001025">
        <property type="protein sequence ID" value="OXU25441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3W2"/>
    <dbReference type="STRING" id="543379.A0A232F3W2"/>
    <dbReference type="OrthoDB" id="7696552at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="184"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="298" mass="33994" checksum="347843F762B6D039" modified="2017-10-25" version="1">MAENYFDNIRTVGAGLDQGIAKLQETWKMPQLILCNQNEEDQQTARKLIDNLRNELKLLKATIDENKAAVQCLRETQTQFLEESTRAIKCLKEEVDDIKVLFAENGYVEDPVEDDLSILNSQLESLFVNDSSSFLKDSNNITESSACDNASMCVDESSTASKESFNMGTPPINHIMHKKLLLEAMIGDTNLFLNDPDDKECAEIEIMIAETTDRGKGFGLESVYLMLQYGIEKLDIKKYSAKISMDNQKSINMFTKLGFKEISRSEVFQEITLERIVDDEWRDWLKSKTLHAIINENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F406</accession>
    <name>A0A232F406_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_010290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001083">
        <property type="protein sequence ID" value="OXU25208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F406"/>
    <dbReference type="STRING" id="543379.A0A232F406"/>
    <dbReference type="OrthoDB" id="5597713at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167132" description="Peptidase S1 domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="246" mass="27325" checksum="FC43DA403C2B504C" modified="2017-10-25" version="1">MKQLLVILCLAVSVYGQSDLGGTDAPDGAYPYQAALRRKSKFVCGASIINEHWLLTAAHCVKMMKDPKEATVLVGTNFVTGEGGHEYKVAYLIQHEDYDRDYIHVNDIALIRLAENIKFTQKVQPVKLPKDESQSYEGATAILAGWGSYGPNNYTPRKLQHIRLQVISRSKCANEWKTSRNRTIMPAQLCTSSATDENMATHGDSGGPLVSDGVQIGVVSFAWEGLPDVYGRVSSYLSWMNRYINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F494</accession>
    <name>A0A232F494_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15 16">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 15 16">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_010630</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 16">Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 16">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15 16">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 15 16"/>
    <dbReference type="EMBL" id="NNAY01001047">
        <property type="protein sequence ID" value="OXU25349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F494"/>
    <dbReference type="STRING" id="543379.A0A232F494"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000080">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="18">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="17">
        <location>
            <begin position="183"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU25349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="379" mass="42053" checksum="D348BA2878872B05" modified="2017-10-25" version="1">MSITVTCVAPVNIAVIKYWGKRDEDLILPINDSLSATLDTEHLCAKTTVRASPEFKENKIWLNGREESMDNPRLQNCLKEIMKRSQLSKDMESWKLHICSENNFPTAAGLASSAAGYACLAAALAKLYKVEGDISGIARAGSGSACRSVYGGFVRWYKGSDPTGIDSIAKPIAPASHWPDMRILVLVVNDSKKKVSSAIGMKRTLLTSEFLTYKAEKIIPKRIEQIQEAILKKDFETFAEHTMRDSNEMHAACLAAYPPCIYMNDTSHLIVELMHQYNSTSDRTKVAYSFDAGPNATLFLLEKDVAELLGILDHYLPPAVDNNLEYRKGISIEVTSPSQSLLQKINFPEQQPGKLKYIIHTQVGSGPKQLPDSEALKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4P5</accession>
    <name>A0A232F4P5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000992">
        <property type="protein sequence ID" value="OXU25582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4P5"/>
    <dbReference type="STRING" id="543379.A0A232F4P5"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="394" mass="45830" checksum="8472D6E05714605D" modified="2017-10-25" version="1">MHEKLIAIQKTNAEYELLPFQFLLLTIWGIWHPKDWPARLKNISNIIFISVFCLDIIICFEMSIYLVLSIGTNDFKLVNIFLTSATITGIYKAIKTMRIRESFRTMLLNYFNYEHLCSLNTKERMIREKNQTQIRKVTIIYSASMAGIFALNAIAPALSQPDSTMQLPVDAWYPYSIQKSLNFWLTYFHQIILGSSLICVHIGIDTLFVGLLLKLVCQINILRYRLQSLTTLCSENYKNFEHFNAMGRKFIYRYIHHQNKIYEFSKVLNNKFQAVITSIPNLCINVYTLSKYSGIINMDYISIIFNTTSSLIQLFITCWYGNEVLLSSLQIKKSIYEMDWTKLDVPTKKLLIVIMARSLRPIAFSVAHVIPMNIESFIKIIKISYSAFNVLQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F546</accession>
    <name>A0A232F546_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_013693</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the WD repeat BUB3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000987">
        <property type="protein sequence ID" value="OXU25600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F546"/>
    <dbReference type="SMR" id="A0A232F546"/>
    <dbReference type="STRING" id="543379.A0A232F546"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000047">
        <property type="entry name" value="Mitotic checkpoint protein bub3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU25600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="326" mass="36561" checksum="F8102261CABBB33C" modified="2017-10-25" version="1">MESRTEFKLKNPPTDAISAVEFGPNSTQFLLVSSWDSTVRLYDIQTNTMRLKYNHDLPVLDVAFQDAVHAYSGGLGNTLKMYDINTNTETVMGTHEEPIRKIEYCGAVNAILTGGWDAAVKLWDPRSPTCVGSYLQPDVVLALSVCGDKFVVGTAKRKVCIWDLRNMAGMFQRRESSLKYQTRCIKGFPNEQGYVLSSIEGRVAVEYLDTTPEAQKKKYAFKCHRIKENNVEHIYPVNAISFHSGYNTFATGGSDGYVNIWDGFNKKRLCQFHRYNAGVAALSFSQDGSVLAIGVSYLNEAEIPPGGNDEREVYIRYVNDQETKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5L8</accession>
    <name>A0A232F5L8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000909">
        <property type="protein sequence ID" value="OXU25965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5L8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="139" mass="15313" checksum="2FD836A391F806C3" modified="2017-10-25" version="1">MPLGAKPTAQMRKATAEEVGASGGQQQNEGSDQNENPRAHCIYCNQHGHSDDACVALVRHASKRAISNPYQKKNNIIKMPVQTIIILLLFERWVEHTNANAGSNNYKNANNAKGKNKDDNDNNNSNGNCNKSNQKNNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F677</accession>
    <name>A0A232F677_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000869">
        <property type="protein sequence ID" value="OXU26135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F677"/>
    <dbReference type="STRING" id="543379.A0A232F677"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000148">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940761" description="phosphatidylinositol N-acetylglucosaminyltransferase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="9">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="462" mass="52366" checksum="B1454F05E8C091B1" modified="2017-10-25" version="1">MASVAALCDLFTFVIRYVKAMSDTMVSDFFYPNMGGVEEHIFNLSQCLLDRGHKVVVMTHSYGNRIGVRYMTNGLKVYYLPIKVFYNQCVLPTMVCSIPLIRYIFIREQIEIIHGHSAFSALAHEGMLIGRLMGLKTVFTDHSLFGFADASAVLTNKCLEISLADCDHCICVSHTGKENTVLRAKVQKERVSVIPNAVDTALFTPDVSQRSKDFITIVVVSRLVYRKGVDFLACIIPEICARYENVQFLIGGDGPKRWLIEEIRERNLLQHRVTLLGSLEHSQVKHVLNKGHIFLNTSLTEAYCMAIVEAASCGLQVVSTKVGGIPEVLPPDLIYLVEPNVPSLIEGLEQAISDFQTNKVTCPIDVHRKISSFYNWHNVTRRTEIVYNSVRKEEEKNLGRQLSSYIQSGVLPYLLVVAWCYIVLQFLEYFVPRRYIDIAKDYKKSAKSSEKQKTKLYQNSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6A2</accession>
    <name>A0A232F6A2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hexosyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_002450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; chondroitin sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Golgi apparatus membrane</location>
            <topology evidence="2 15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01000815">
        <property type="protein sequence ID" value="OXU26361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6A2"/>
    <dbReference type="STRING" id="543379.A0A232F6A2"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047220">
        <property type="term" value="F:galactosylxylosylprotein 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000018">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF3">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU26361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="315" mass="37008" checksum="30472D294A63A7BC" modified="2017-10-25" version="1">MPKVKLSLIYILGIFLFTIFGVHHFSTLQCSDKNKKLVNKQKFRLLILVLSAPENTERRDTIRKTWLSLRQDEVKSFFAIGTLNFRPEQLQTVESENQKHNDILLLPKLLDSYGTVTKKVLQSFVHMYENYDFDFVLKCDDDSFAVVDQILKELNRWQNKGLRKELYWGYFNGRARVKRSGPWKETDWFLCDYYLPYALGGGYILSYNLVKFIAENEDILKLQNSEDVSVGLWVAPVANIERKHDPRFDTEYRSRGCSNQYLVTHKQSSQDMKKMYEFYTRTGNLCAQEVSTYLGYQYNWTVAPSQCCDRRPGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6M6</accession>
    <name>A0A232F6M6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000900">
        <property type="protein sequence ID" value="OXU26017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6M6"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF64">
        <property type="entry name" value="SISTER CHROMATID COHESION 1 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="781" mass="88218" checksum="35B425F446B6A0E8" modified="2017-10-25" version="1">MQMTEFFAENLRFRKNEEKTPLQTCWCAATIKHFSSICGIIDSVDVVAVCDEIKNKFVETQGKARCSLYLASQLMFGVVKVYQAQTDSCLRACQNLCESFMLRAVTKKKATKKKDNEYGETKSSPAEASPKIPEIPEVDIFSLLEKDSAKDVNLIEEIDFPSDHANDLSFAFSHDAESDDAAMEEEFDRELQRTLRQEKDIPPRLSTDSPLHEKAPSIDNVQSPHIPGNENDAMDQDQMSLDENHIHDDMRRKLQETPIRKAHPILRDINESTPANVRAGFSPLASKVPSLPQLPLFMSPVLGKRKRRPLTLGRDVTIVEPIAEAALPTDSPQQSRLPMECATPPRLFSTTLGAFESPSENDELPDRQSNIQPEKEKESAIENDEAIESISGKKSSSLLADDEDSTKSLSQSRANSQKVTTMPTDNSANRRRAKKRTFQDSEKTLDDGDFAKRLKNTNYLIKKKEKVLVTSSIFSQLSAARFLLTLPCVLQKQSSISNRLMQLYQQDIQVLQKLAKTPTEPQHSSQRSGNHFYDEEESPHPSPAATVIEENVEDDDITMPKDNVLNKQRLQSPTGVPKDYVNDEDEVQDNNISLTDPAVPTSCITAQVNSSQSTVVGTVSSSASLNKENEQIFYRPASPSTSIQSNPSQLFETSQTAHINEVSKEIDDKQQENNQVLHQAKKFKAGDTEFEIDLTVQTSKTIFLSIEDFYARVKTFWNECDKLNRRTNGKVMAVFQEVVSPENSNLYEVLKYLIYCFMLERDRKMDLHQQKPWNSLYILQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6Z8</accession>
    <name>A0A232F6Z8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000815">
        <property type="protein sequence ID" value="OXU26362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6Z8"/>
    <dbReference type="STRING" id="543379.A0A232F6Z8"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF9">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008744" description="Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="5">
        <location>
            <begin position="104"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="6">
        <location>
            <begin position="396"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="61634" checksum="69F0A4F1CDC32D7C" modified="2017-10-25" version="1">MMTHIMSLTPSRRRWLVVLCMILVPCVILNFASTPDVHEETLLQHSIAELQVKLEHLHSKYINSQEEIQLLTYQLVQLTEGAHLLPDVQVFINNSNYNVTNVKLPSVYNFLPHLLSDPNSLRPAFIHSKGRSGVSIVLGIPTVRREVQSYLMATLKNLLDRMSPQETADTLIVVFIAETDIEYVTYVAKQIEVHFPDEFESGVIEVISPHPSYYPDFAKLRDTLGDNHQRVVWRSKQNLDFAFLMSYAQAKGTFYVQLEDDILAKKNFITTMKSFALQKVSMKENWVVLDFCQLGFIGKLFKCVDLPWLVQFFLMFYNDKPVDWLLDHLISTKVCSLDMDNKRCKMAKAELWLHYKPSLFQHVGTHSSLKGKVQKLKDKQFGKITLYYGHQNPDAIVESQIKPYKQFTLNKAYKGDSFFWGLLPQPGDHLRFKFVHPIFIKRYLFRSGNAEHPSDKFYNTTVEVLPQSINSVDRNHNNVTEDGYIIVGKFDSLGIARGTVDKKLGKIAVLRLTVHSESDNWAILSEIHIEEDFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9M7</accession>
    <name>A0A232F9M7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000580">
        <property type="protein sequence ID" value="OXU27571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9M7"/>
    <dbReference type="STRING" id="543379.A0A232F9M7"/>
    <dbReference type="OrthoDB" id="17335at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28592">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28592:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="31331" checksum="9169D0A3BE9A58E3" modified="2017-10-25" version="1">MDEESTLDPTKLRPTLETYKKLSKDISNHDTILKDKTVLSYVAVVLEYPDDEIVHLALDILEIFVKNVENYNHITSTFGVREALDAVVNKYTLDEPKLAKRAQQIKDDIERMKPPIYNLRSRCRRVIEPKKLRTHVIVLHVHGLLPETRTELEYTLIRIEGLISLVVDVEHQRVTMRTLANVTAKQIAEAISENNPNMEARLVTRNKNNQEFLVKLVNTESGDCEDMPEYLPEDEDPEEEKEGVVSLFTGLRQSASSLYKSTAEFLSNSFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9Q1</accession>
    <name>A0A232F9Q1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LRRNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000653">
        <property type="protein sequence ID" value="OXU27168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9Q1"/>
    <dbReference type="STRING" id="543379.A0A232F9Q1"/>
    <dbReference type="OrthoDB" id="1574204at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012534012" description="LRRNT domain-containing protein" evidence="6">
        <location>
            <begin position="27"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="548"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="88266" checksum="CD1D812C8B1E2262" modified="2017-10-25" version="1">MAEETLGKSVVSWLVLVLLLLLEVKAHGCPARCQCNLVHVPRTVNCAGLGLQAFPENISDVVEHLDLSGNLLTELPAEVNRLTELQQLNLARNKLSSLPVNLRGLGNLRKLDLSENALKDPQPDLAGIAHLARLKTLYLAGNPLAELDGLKNAALQFLSADSCGIERLKNTSLSGLPELTKLSLSGNPLKDIKDPYSLKLKGLDLSKCQLKVLSPRAFQGFPELIDLRLADNPTLVYSTRYETLRHQKLQKIDVSRCDLDRPGLHGFPSLTYARLSSNSIRMLPDRIFAKNRELTHLFLDYNHLERLNKSTFANLLRLQVLDLSANGLKAVPSMAFRDNIELQFLNLSDNYMVDFPKLSTSVISLDLSANLISRVDPNSLSGTPSLYHLNLSKNLIDEMPSGLDSGTLRNLILRRNRITSLENVSLSGLPELEKLDLSGNMLTKGVTPEIFFDNPNLRHLYLHDNPWICDCTQLYPGYMFLTSLAAKTETLICHSPKNVTGFSWKLACANEWKREILHKSSNKTWGLILVSLLTVVVLTGTIISIRHSMKLKRQARNQRLEVERAEVRERLRLLQRRFVPLFILTFLLKRSQRLQEELREVTSEPRIHPMELIGPPSYEEAVTMPRLARSLDALDTVTTDSRSTTVIRMTGSSESLRGGKKRRRPRRLRSQSEDNLTRREMRRQERLRRVRETGPTAGQNDNVVNRQEDDPDDKEGRSRNRPPTPTAAKRKSIRRMSTRNGTSTDDEDSEGGGDAGGRRIGRTVIRNLDREPRSGYRPSTDGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBH5</accession>
    <name>A0A232FBH5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aladin seven-bladed propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000558">
        <property type="protein sequence ID" value="OXU27677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBH5"/>
    <dbReference type="STRING" id="543379.A0A232FBH5"/>
    <dbReference type="OrthoDB" id="411991at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045139">
        <property type="entry name" value="Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057403">
        <property type="entry name" value="Beta-prop_Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494:SF0">
        <property type="entry name" value="ALADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494">
        <property type="entry name" value="ALADIN/ADRACALIN/AAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25460">
        <property type="entry name" value="Beta-prop_Aladin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aladin seven-bladed propeller" evidence="1">
        <location>
            <begin position="143"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="535" mass="58998" checksum="B580952C621D0654" modified="2017-10-25" version="1">MLKVLSLRDFDPPSFSDLATASFAHNGLVYCSKQELQQEAQSCCIYLRDFPAVNITQEMLATRETHRTIGARDLFLPVQDSAFKKVVSIWREKGLLEAIRTAAAEDPAEITHPVHWITTRITRMLDSIEGGTFWSSILPSSGSGSVADVAATRDWTTALIRCIAWHPNCIRLAVATRDDRIRIFSTGNIATAILRHSAQKSVCCMSWRPNAGRELAAACQNGVLVWNVELGAASNSLSHAFMLKHRNHAPVTSVSWSPQGDVLVSCSLTDMNMIIWDVAKESGIPLRRVGGGGLCFARWSSCGSRLLATTCRKIFRVWNIGAGTPWKAERWTVPNGRVAAACFGPNLTLLFTSTEDPAMVFSLPLQEQIFDLKKIGTTDDNKVALPLIDLSKVTFMSNDEDMQVSVGGRVISMDWDPLGKYLAVIFQDSPLVALFKTKIGNTSRITEVKPMCLVKGFPGEVPNCIQFYHNYKQQSDASILTIAWSSGSVQHFPIIDSPHAEPRPELGKTVGAMNNTFSITEDFQTSLYSSFSMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC00</accession>
    <name>A0A232FC00_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000464">
        <property type="protein sequence ID" value="OXU28185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC00"/>
    <dbReference type="OrthoDB" id="7701343at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="79" mass="8629" checksum="8CF884FD64610A9E" modified="2017-10-25" version="1">MKIKYRKNIRSQGSHAKQNSNGNSVVTVDEKGFREQDIPGMVKDAQAQRGGTATLPCKLIDNGAGIVSIEHDWTFIAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCA0</accession>
    <name>A0A232FCA0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000503">
        <property type="protein sequence ID" value="OXU27957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCA0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9528" checksum="2296866A3173CD6D" modified="2017-10-25" version="1">MESIVFHKSKISDTNIEPERYATKDINYSTYKDTAIAMGLLEHDSQIMDIFEEASTVMLPTQLKQVVAWFLGTKCLIVLSSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCB6</accession>
    <name>A0A232FCB6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000446">
        <property type="protein sequence ID" value="OXU28325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCB6"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="199" mass="22631" checksum="CA31663AD2A060EE" modified="2017-10-25" version="1" fragment="single">TSASRESRLTLSLPSASRKSVQQCWCVLDSFDTRREKNPRKGGAAVENLAPAGSDRRAPPRSFRGTRESKRRAELCLSIRAVEMTRAMMEVTTRTSYASQQQDVQRMRLVSVGNYETTRLLGRGNFARVVEAVHSVLKAKKPPLHCLLNAEIRDRLFLFAVLQEYIYCAFPEIRPDTEPMPRPKGFVAFINPPYFPKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCW7</accession>
    <name>A0A232FCW7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000401">
        <property type="protein sequence ID" value="OXU28646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCW7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10892" checksum="C769BE3648E7F2D0" modified="2017-10-25" version="1">MEWTEWYLYTSRYIPVQRETEEFGNDSGVHICSWAYVLCTSKAKRFSENDMNSAIKGIANILAENYINEEQAKDKIKLCRELFKDYDPKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCX3</accession>
    <name>A0A232FCX3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemocyanin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000444">
        <property type="protein sequence ID" value="OXU28340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF5">
        <property type="entry name" value="FAT-BODY PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemocyanin C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="79" mass="9121" checksum="303DD576D695BF0B" modified="2017-10-25" version="1">MWPMLLTRXRGKPDGLTLRLFVIVNKFDEDKAVHTDSLIAGKGLLDSRSLGFPFDRPIDHLKFEGTNFAFKDIVVYYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCZ6</accession>
    <name>A0A232FCZ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphotransferase</fullName>
            <ecNumber evidence="14">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_012860</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-mannose + ATP = D-mannose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11028"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:11029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="14"/>
    <dbReference type="EMBL" id="NNAY01000445">
        <property type="protein sequence ID" value="OXU28329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCZ6"/>
    <dbReference type="SMR" id="A0A232FCZ6"/>
    <dbReference type="STRING" id="543379.A0A232FCZ6"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000095">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="15">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="16">
        <location>
            <begin position="217"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU28329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="456" mass="50687" checksum="E85F37953CAB2F38" modified="2017-10-25" version="1">MKMTPSLCTSDLLKPEIRDACKDLILTDEQLRLVMERLRHQIDRGLSKQSHEEAIVRCYTTYVQDLPNGTEKGNFLALDLGGTNFRVLLITLDGQSFDMKSKIYAIPQSLMLGTGRQLFDHIAQCLALFVKDLKLEQEVLPLGFTFSFPLSQQGLTKGLLVRWTKGFNCSGVVEQDVVALLEDAIARRNDVKIDVCAILNDTTGTLMSCAWKNKNCRVGLIVGTGSNACYVEKTENVECAIPGQYAAHKPHMLINTEWGAFGEQGTLDFVLTEFDRDIDENSINPSKQLFEKMISGMYMGELARLVLEKLTNNGLLFNGKCSCDLRKRGKFFTKYVSEIESDPKGKYANCREILAELGIRNATDQDCENVRYVCSVVSRRAAHLASAGIATLLVKMGENNVTVGVDGSVYRFHPHFHDLMVEKISALQPYKFDLMLSEDGSGRGAALVAAVAAQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDH9</accession>
    <name>A0A232FDH9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000425">
        <property type="protein sequence ID" value="OXU28499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDH9"/>
    <dbReference type="STRING" id="543379.A0A232FDH9"/>
    <dbReference type="OrthoDB" id="6372059at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF241">
        <property type="entry name" value="CUTICULAR PROTEIN 47EG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011292010" evidence="3">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="131" mass="13792" checksum="DB5BE8AEB1530292" modified="2017-10-25" version="1">MNAALLSLILFVACAAAAPADPQVIPIVSQTQEGPNPDGSYKWAYESGNGIKANEEGQVKNAGSENEAMQAQGAFSYKGDDGVDIAMTYIADENGFQPQGAHLPTPPPIPEAIQRALEWNAAHPEQDGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDT9</accession>
    <name>A0A232FDT9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000371">
        <property type="protein sequence ID" value="OXU28835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDT9"/>
    <dbReference type="STRING" id="543379.A0A232FDT9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="48" mass="5528" checksum="1A06E2C9A0164EA6" modified="2017-10-25" version="1">MSSTTFVDRIDPFAKRSLKKKSKKSQGSSRYRNSQDVELQQLPQLKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEC2</accession>
    <name>A0A232FEC2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_003562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000380">
        <property type="protein sequence ID" value="OXU28779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEC2"/>
    <dbReference type="STRING" id="543379.A0A232FEC2"/>
    <dbReference type="OrthoDB" id="7544260at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="69"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="9">
        <location>
            <begin position="329"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="552" mass="66309" checksum="EC9A74FAA9BBB0F9" modified="2017-10-25" version="1">MKAKKVLLRGMILMQIVIAIILYHKYIQSLDHQNYPNRVFNPHDRLEIEKRVLTKMKKRWDVYNLQNVKFGKDRYFLWPYGIVPYTFEKNYPLEWAMIFEKTVRYVKRTTCIRYRRRRPQDQDYIEVAHLNITDACNRGITGYFRGRTFLYLQSHCIHDRGLTLHMMMIVLGFYDQHNLHNRDDYINIHWDNLIPEAKAYLYKYRPEDSTDFGLPYDYHSVMQLYDWVYTNKENVTTFSPKIKGVTLGPRNKFSPDDIMKINTLYEWECAAREYKERGMIVLKILLCLTLTCECSVNPLMHYLDVHQLHEVKKIVLTKLTRRLEIYNSNKLRFGTDRGRIWRYGIIPYKFTYAFPTPIQYPAMDLARKFEQLVDYVNNSTCVRFRPYRRDVDVDYIEVATYREKLCTIFYGRPSYTNAVHFPAWCIYDNKTGLNQLMRLLGFEDMQRHPDRDKYVEILWQNIMPGKESYYSKMPKELFSEFYGMAYDYHSVSHLRDWEWAINGSKVMIPKIKGVTLGSSANFSAEDIAKINLFYEWECSLREYKESVSKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FED8</accession>
    <name>A0A232FED8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000369">
        <property type="protein sequence ID" value="OXU28838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FED8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="189" mass="20628" checksum="4CCCE71014BC8662" modified="2017-10-25" version="1">MINIDKKAKQKENKTNINASTDRTDSRNRAHSSSEKTTAPREKGRPVGAKTNKNAPELDHSVIAQRTRGRRAKVESPIATYIMQGAIPKVPKSIKHAKINNPVEKPFLKATKSASETIATSEEESSKGTQSDTDSEAPTSRKFSSSRRSWLSSTALAGRDPDLDGDTLSTDSQNRTISNIKVLVNAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEH4</accession>
    <name>A0A232FEH4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small lysine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000358">
        <property type="protein sequence ID" value="OXU28920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEH4"/>
    <dbReference type="STRING" id="543379.A0A232FEH4"/>
    <dbReference type="OrthoDB" id="5989977at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037760">
        <property type="entry name" value="SMKR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37932">
        <property type="entry name" value="SMALL LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37932:SF1">
        <property type="entry name" value="SMALL LYSINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9719" checksum="1F30B91FB5E46F8C" modified="2017-10-25" version="1">MPDKGRKKSTGKKNGKNGNGNGGGSGGKGKSKGSKKGSKRSGGKAKFTMDVFNEEAMETAYYTCHNIMDVLFCRGFPWPEAQKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FET0</accession>
    <name>A0A232FET0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000374">
        <property type="protein sequence ID" value="OXU28807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FET0"/>
    <dbReference type="STRING" id="543379.A0A232FET0"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU28807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="350" mass="38080" checksum="DDDC11C38CBC3EC3" modified="2017-10-25" version="1">MTLQAIKWKSGKLEILDQLLLPAQSKYIEVTSVEDGWNAIYNMQVRGAPAIAIVGCLSLAVEIQHKSYDDTKALLKDVKEKLEYLITARPTAVNIRLAADDFTRLATKLSHDESSPEDMKKRIISEITSMLEKDVADNKAIGDHGAAEILKTHPNEKNLRIITHCNTGSLATAGYGTALGVIRSIHSNGKLEHAYCTETRPYNQGARLTAYELVHDKIPSTLICDDMVAALMKSKNISAVVVGADRVVANGDTANKIGTYQIAVLAKHHNVPFYVAAPFTTIDFSIPTGEGIKIEERPANELTHVNGTRIAAEGINVWNPAFDVTPAELITGIVTEKGVYKPAELAGLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF43</accession>
    <name>A0A232FF43_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_015201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000295">
        <property type="protein sequence ID" value="OXU29386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF43"/>
    <dbReference type="STRING" id="543379.A0A232FF43"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000232">
        <property type="entry name" value="Organic cation/carnitine transporter 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF38">
        <property type="entry name" value="SYNAPTIC VESICLE 2-RELATED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="2"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU29386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="486" mass="53669" checksum="68B2785893B3D7C5" modified="2017-10-25" version="1">MLLAISGLIYMDTAIGVTILSFVLPAAQCDLRMDSTSKGWLTAAPMLGMVIGSYIWGCLADTKGRKIVLIATLLMDGIVGILSSFVQYFWVFLVFRFFNGFAVTGAMGIVFPYLGEFQPTKQREKILCWMEMFWTVGVIVLPLIAWLIVPLDLSYQTSGFDFKSWNLFVALCALPSLMLGLWLFAFPESPKFLLECGETEAALEVFKYIYAQNTGNDPDSYPIKSLQEKPNSKDKSTRALKLHKRKDLKVLVAEVWDLTKALCKPPYLKNTLLACGIQFGLTSSYYTLMVWFPELFTRFEDFEEMHPGESTSVCIVSALDESNNSTIQDPYGCETTIASSVYLHTVYIGLACVPGSIVLPLFVHKLGAKFFLILSLMVSGGVTVGFYYVTNANQNLVLSCIFEALTSLGISLVYCVIVDMFPTNLRVMAAALSLTMGRLGALVGNLVFGYLIDLACVVPVALFAAFLFACGFLSIFLPKTGKDTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFY0</accession>
    <name>A0A232FFY0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000260">
        <property type="protein sequence ID" value="OXU29661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFY0"/>
    <dbReference type="OrthoDB" id="10538459at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="177" mass="20798" checksum="A922CB9EE9971754" modified="2017-10-25" version="1">MSNGNNSMFDILMEIRKVDKQISELKSKWEKSQQDLMLVERSISNIKDLQMKAALVLIKSERQIEDTNENLKGIHENYFKFIEYIDEQIEDASEDEEENVMSNMDKLKKIRDNLKDKIDAAKSEKERVALEVNEIDLQISIQKKKNAAMFLRLQKDLKKCLQEERNLKDELMSNGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHQ2</accession>
    <name>A0A232FHQ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000185">
        <property type="protein sequence ID" value="OXU30202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHQ2"/>
    <dbReference type="STRING" id="543379.A0A232FHQ2"/>
    <dbReference type="OrthoDB" id="8063677at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="317" mass="36573" checksum="FC9E74272FE32FB6" modified="2017-10-25" version="1">MVIRLLSVLPRFSAFRMAWECTQTEQQKKKNLIARLLTEDKRLCEEDSSTDFPQKATSDSKPVQAHSKATKSYKKKNIEELKKRTKCAVCKQKRHWTRECPNKNSSENKQKNAGAFAVSAYVSDVPNEDIWLADSGASMHMTSRGEFFTSLNVASTTRQVKIDGKTLPVSGQGTIIICERLNDIARNLFSITAINDKKYSFHSYEKHYEVWDSNGKLSSRGVRHCGLFKMLFKVKISAKCKVVESKECHVKCNVDKPKEQNSLKLWHEWFGHILISNDVDFNESSYTNLQQEDDLFRERDKKRLKTKQQQIINKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJF0</accession>
    <name>A0A232FJF0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000129">
        <property type="protein sequence ID" value="OXU30713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJF0"/>
    <dbReference type="STRING" id="543379.A0A232FJF0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="115"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="207" mass="23631" checksum="34CA63F5F1F37339" modified="2017-10-25" version="1">MEGFDEDYVLPSSSISNLGNVTIKEFKLHLTLKRDYVSIYVGLLCLGSCADDKFVVVGHRSFYNFYNLAYNNNKFDISQSDKLFCPFLDNQMHRQLLFIFKISDLASMLDKGQLSDATLVVRCKDQSHRDFHVHKAILSARSPVFATEFEPRVTAVTRTCIQIDLTSEIVRLEDFADMLRYIYTGRVASVQERNLDGLIHLAKPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJI4</accession>
    <name>A0A232FJI4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000137">
        <property type="protein sequence ID" value="OXU30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJI4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="43" mass="5299" checksum="0727B19FECC0B2E5" modified="2017-10-25" version="1">MKIVCRNYRFVFSKIITYSSISYKSYALPKSYNRYCYTYRHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJN6</accession>
    <name>A0A232FJN6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000132">
        <property type="protein sequence ID" value="OXU30678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJN6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="148" mass="16211" checksum="7E505A914CA54D42" modified="2017-10-25" version="1">MERPAMKQAGERKEDSEESLFVELLRGQSQTGICPLKEAQRALVGGREVDRHRVFSSTKGAFSRGSGNGTLRISSEMTLGLRRCPRSLGAVGLRFVDNSFLIGGFLFRGEMQILLRCSVCTYCLAAIFRLMICSCAVEIATARVGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK67</accession>
    <name>A0A232FK67_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000113">
        <property type="protein sequence ID" value="OXU30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK67"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012782495" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="8049" checksum="092DA431F2F37B07" modified="2017-10-25" version="1">MLTKVLLLVLLGCTVALGATYYPFPGDCSLFQECDEHLGGCVIKTCGPGTEFNPAVGVCDWPLADRSNCGNPDIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKU1</accession>
    <name>A0A232FKU1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000076">
        <property type="protein sequence ID" value="OXU31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKU1"/>
    <dbReference type="STRING" id="543379.A0A232FKU1"/>
    <dbReference type="OrthoDB" id="6408700at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46585">
        <property type="entry name" value="INTEGRASE CORE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144685" evidence="1">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="171" mass="20194" checksum="F301C8BADE76179D" modified="2017-10-25" version="1">MSGVLPFRLSYLLVVIDVLTEYAWGKQLRDNMTKSVFSGLEQILQRNDSRQLYTFKRTWARNSLDAKVQNLLKKRNIIYRAVRDPDDKAAVAEHFIRTLKERIWCYFTHLNTRRYIDVLDGIVDTRSQPPVYTFKDLEGEKIDGYFYEQKLSRVCKDLSGDVLEVLVFTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMD4</accession>
    <name>A0A232FMD4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000052">
        <property type="protein sequence ID" value="OXU31517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMD4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="173" mass="19098" checksum="B313F0988B0469A9" modified="2017-10-25" version="1">MFAPVLKMSLEARDFIQAAINVKKTKRKDVTEKSNSTNNSIQESEHPKKLERDLISPDILASFKQAETDGVWNGDVAYVALFQSWLKLRKIPDTEITATISNESSGTDGSSLADHEMSENIAVDMIEDQMLDNVWNSQVIDITTESVEGQMPDANSTESTAANISSEIVDEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FP37</accession>
    <name>A0A232FP37_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_007065</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000002">
        <property type="protein sequence ID" value="OXU32289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FP37"/>
    <dbReference type="STRING" id="543379.A0A232FP37"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF514">
        <property type="entry name" value="B(0,+)-TYPE AMINO ACID TRANSPORTER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU32289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="502" mass="55847" checksum="CBE92AF75D5D3E9C" modified="2017-10-25" version="1">MSKAKKEDEVEQVGLKRELGLMSAISMIAAVMIGSGIFVSPASALAHSGSVGFCLIIWIVCGILSLLGALAFAELSAVVPRSGAEYAYLMDAFSPLHRYFGPLPAFICSWVFVFVLRPAEVAVVILTFAEYFVQPFEPYVGELTREHWDHVKKLIAILALGLIVYINLTSVKLFVKVQNVFTVCKIAACILVIVGGIWWLATGHTELLSDPFFNTTTKPGEIALAFYGGLWSYDGWTAAAVVAEEVQRPEINILLSIVIAVPIITVLYVSMNLMYMSAIPVQEMISAPTVAILWAKNVLPEWLIFAIPLGVALSTFGCALSLQFGVARLCYVAGREGHVPSFFSWVHYERMTPAAAVTLQGLLSLFFMLVGDILKLIDFASFLIWVFYGLSMVALIIMRRTKPDVKRPYRVPIFIPWLVLFIAIFLTVMPIIDNPSLMYLFVLFFILLGCMIYHFYVYKKRKSRFARKLTYLVQMLFMVVAPDEVESESDEAASKKLTKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED03</accession>
    <name>A0A232ED03_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01011491">
        <property type="protein sequence ID" value="OXU16222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED03"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="8301" checksum="E6908A3BAC76F758" modified="2017-10-25" version="1" fragment="single">FSYNDDRGGTVYVVAWCLYALDHPRLRINICYFQFFFVNDDRGDVVYVVAWYFYALGVESESQQIFFSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDA5</accession>
    <name>A0A232EDA5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007386">
        <property type="protein sequence ID" value="OXU16323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDA5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="139" mass="15453" checksum="1E2A27D000FB42D9" modified="2017-10-25" version="1" fragment="single">VTVSFSPPGKLPIVMALLNKYEPNNTRIFRITKQGADNATVRHNYYDLSRRVDQVANRKETAEPANNLVTSSSTDDSDNTDNSGSTSNADDSDSNGQTTRTTTTRLFQTMRLTTIMKTMARKISQRTVTMTIETLTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDS3</accession>
    <name>A0A232EDS3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005947">
        <property type="protein sequence ID" value="OXU16509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDS3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="190" mass="20473" checksum="2596DF54C15C364B" modified="2017-10-25" version="1">MTSKSNLITSQNSKVPIAKDAKAISSPATVKGAITNVQLTTGAQNITLMEVQMDTTQHQAQTHKSETPVKAIESSKPVEIKIPTVLKKVVKKEHQKSDPRVFKALPGPALFSTADLIRCVGSTESRTPDSLVTTTLTTPSAVVNNANMSFSGVSASGCTVATESLNTTYERSYYIACANGYKHFCNRFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDX2</accession>
    <name>A0A232EDX2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005912">
        <property type="protein sequence ID" value="OXU16522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDX2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12867" checksum="2F1720A9303ACEA0" modified="2017-10-25" version="1">MLKRQDTPGELPEEGRKKKIIMLEAAHNFPLFCFTPPTLFIQLFNFLTIKIRFTTSYGVKSTLFNKILKEPTNKRKHFLTSVTVLQKLTFYGLKAAICVDKRYQRLDRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE27</accession>
    <name>A0A232EE27_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005713">
        <property type="protein sequence ID" value="OXU16584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE27"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="11000" checksum="9BD0340590FE9A63" modified="2017-10-25" version="1">MSPAIVDFVVQNNMPLVWDDLLNDDEELQLPSCTTSTSNSIRELINNGEFFNAEFWYLIRDIKLISCFMMIVLHYTGYGLHVQRISEHFKILIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE33</accession>
    <name>A0A232EE33_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005583">
        <property type="protein sequence ID" value="OXU16621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE33"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12977" checksum="646EBAA4A02E1937" modified="2017-10-25" version="1">MERISEGLLFNKLSSSFQLSNQNYEKYADEIENINQNNWSNNFAPQNKFPRSTGPPNFISEELHYQEEQQLEEVDYNEKQENINGDDSNFQNQENVETANFQQDANTKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEY5</accession>
    <name>A0A232EEY5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_003194</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Postsynaptic cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005220">
        <property type="protein sequence ID" value="OXU16872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEY5"/>
    <dbReference type="STRING" id="543379.A0A232EEY5"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000038">
        <property type="entry name" value="Muscarinic acetylcholine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF265">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="60"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU16872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="572" mass="63968" checksum="7C8F45CA954EDC64" modified="2017-10-25" version="1">MNVTLVTTCLLPETCNETSLLESNLTGIEDDGPLGHQYPVWKVILISIVAACLSLVTVIGNIMVMVSFKIDKQLQTISNYFLFSLAVADFAIGLISMPLFTVYTVLGYWPLGSHVCDTWLALDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTVKAGIMIACAWGISLLLWPPWIYAWPYIEGERTVPDNACYIQFIETNHYITFGTAIAAFYVPVTVMAFLYWRIWQATEKRQKDLPNLQATNKQDVSKRSSGLSDEALDMEVCCERPRSESSTGAGYEVNSTHIAVSYLDRHYPQHRVKHRPLSWTWLKMWCVAWWHSGREDDDEEDDDDEPGGPESSRTVTTTQHTHHLVCPSQVYTILIRLPGPPARSKDAQMLGRYGAVEAPSIKMYPDDVISFQPLRPGMELNCDGQEIIVSASSTAATSQMQQDVRIPLSAKNIPGKQVAGKSSSSSGGGKAPAKKKKKSQEKKAEKKAAKTLSAILAAFIITWTPYNILVLLKPLTACTGCIPQELWDFFYYLCYINSTVNPVCYALCNATFRRTYVRILKSLVQEVTEPSTVAHNFTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFP6</accession>
    <name>A0A232EFP6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004989">
        <property type="protein sequence ID" value="OXU17132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFP6"/>
    <dbReference type="STRING" id="543379.A0A232EFP6"/>
    <dbReference type="OrthoDB" id="6777429at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="739" mass="84561" checksum="D27D448B56C04639" modified="2017-10-25" version="1">MNELEDEPDDVQKATPVEDELKRAEIDKLSTRTMAVPKVDAQPRHRCQKEPAIQKIDCCEAKRQRQLESSRQKTVTMYVHEEPCKLVKQEIIPRHCMSKEEYIDFLAKPSEKCPSPCAKKPVKRRVRAMSPRIDELAKPTARRLRNTLEDKADVLSAQMVDNLVEVLEGETALTAEQAENFVRDLRASKKSSKPKKRKMKCKSSPKPPQPIFEGGDPIDPEVADHQYSIAKRFVRSILNFKCPIPREDYQDISETVLEILSEQLEYTPVGNEDRKSRQMRILADSFACWLSGILLRVSEKHKEELEEECLKKRREMEELAAREAMMADDADDEDEGDDDLNEDRSEDDDDDDDDDEEKLLSKAESLARSLAQSEADEEGEGEEDEGDDSKTYKSDGVSIAVEDSTTQYEEADIEGAVVQKPDEDLLTAASLKAQSETRTMASRTDLTSEAEEDALTQAMSEAEMTALEEEEQSLLLLEEGVDEQQQTEPEVKFDAETETTAELRTLRSEVSAAKSREQRELERIASKMSKAFETDVPFLTFAKLADTLYTMLEAHSENKLSDPIDNRLHRAIYEKLSEAILREDPSLLTDRTRDVVDVVSGKITSWLKKTLDEQQIKFLDEEAPAKIESREVREWSEWLENLTDQADIWSKWIEKVTGEAKLMKTEGKVTRGAWQDWTSKFDSNALRWRETYLKARHQEHWNTMMMAERKVLKTGTKSRPAALQEKTIKNTNFESSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFP8</accession>
    <name>A0A232EFP8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004977">
        <property type="protein sequence ID" value="OXU17148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EFP8"/>
    <dbReference type="OrthoDB" id="7700340at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023263">
        <property type="entry name" value="Arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15962">
        <property type="entry name" value="ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15962:SF0">
        <property type="entry name" value="ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1266" mass="145756" checksum="96F7853D4F1D5DFE" modified="2017-10-25" version="1">MVNTRNQSGGSVNTEMDGLRRDLEKALTEAATARKENDSLRTQLDKIIQLNEALLAERDERNRNPHDEGNGIPNNDGRDSDLSRDLSQGNLNAQLVQGMLEHFQALNINLNIPIYHVEKCNPAEFIEKLEKYFIRKKISQNQKLIITEDALKGRARAWFEARLVPFINFAHFKTQFLQEFYSIEARTETKNNWSMRKFKSSDGSLLEYFTEQRRIAKYFNPPMDNYEMNYYIVKQLPGRARDVLSVIDYADVERIDHALGRLDASYRENSENKVPGQSNIKNNVPSYRGPPHXTRHCWRSVMREIETHMTKGNLNAQLVQGMLEHFQALNINLNIPIYHVEKCNPAEFIEKLEKYFIRKNISENQKLIITEDALKGRARSWFEARLVPFINFAHFKTQFLQEFYSIEARTETKNNWSMRKFKSSDGSLIEYFTEQRRIAKYFNPPMDNYEMNYYIVKQLPGRARDVLSVIDYADVERIGQALGRLDASYRENSENKVPGQSNIKNNVLSYRGPPHQQQQRSTVNYLRETHGARKENDSLRTQLDKIIQLNEALLAERDERNRNPHDEGNGIPNNDGRDSDLSRDLSQGNLNAQLVQGMLEHFQALNINLNIPIYHGEKCNPAEFIEKLEKYFIRKKISQNQKLIITEDALKGRARAWFEARLVPFINFAHFKTQFLQEFYSIEARTETKNNWSMRKFKSSDGSLLEYFTEQRRIAKYFNPPMDNYEMNYYIVKQLPGRARDVLSVIDYADVERIDHALGRLDASYRENSENKVPGQSNIKNNVPSYRGPPHQQQQRSTVNYLRETHAHGGNNHRPEQFSYDNSQYHGNSQNDNNRSGAMQNWRVGNSASENNAFCLPDTSRPPPSMVNTQIEDASANKRQQTERLGFDSNTTAIRALERSEFILELCYDVERNDGPIDWNNDSLRVCTLRYCRAQYVFYLTLVREHDIPELPISNLTVHVAVGKNIVKVVRKAKKIVKVVRKTYMAMKIWKFNLDYTFIVVPGLSTEVIVGADFLKKFGGIINFKTEAFELMNEVIPSELVSFRPVLGLNTYTMSASKDIPSPSENQERSMIMGGVLEVEPIEKEITAYIENIDYLKPHEKAEARALLIKHKEVFSDEPGCTNVYEHEIRLIVDKPIIRKSYPVPIRQQPAVDHAIKKMLEQKIIAYSCSEHCNPIRIVTKKERQPSDNESSMRIEELIQAGVADAVNNALLAGVAAESLVHVLVDAAECKGRVTGEVNDAFFILISPAAVTGDAPEVVVRESGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH54</accession>
    <name>A0A232EH54_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_016053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004612">
        <property type="protein sequence ID" value="OXU17661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH54"/>
    <dbReference type="STRING" id="543379.A0A232EH54"/>
    <dbReference type="OrthoDB" id="2377365at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21989">
        <property type="entry name" value="HMG-box_HBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049523">
        <property type="entry name" value="BBX_HMG-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF10">
        <property type="entry name" value="HMG BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU17661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="484" mass="54500" checksum="C423BA6238D7F2DE" modified="2017-10-25" version="1">MAANEHQQREEEDGHEPAHHARRPMNAFLIFCKRHRAAVRSGFPHLENRAVTRVLGEWWAMLSTEQKKAYTNLAQEYKDAFLNANPDFKWYKLPAPPLRTLNTRPTNKKTDGGLSDSGSETIKSDYLTLNVSKLDEDSIQPGKLADESQLGGLSSLFTPQKVNPQDCQSSTNNFVSEDEANDNSEVPKPPKKRYTELPISAESKEDCKADLFGDKKSRTESNNNDHHLMNVDEDENDETHTYIEDTSVEDSAFRAGRSCKGLRYQKFLAEQLATHQAKQRRIAGLPNIEHNRERRNSISSNVSEKTDSLSSEGTSSRGDLEHLVQGGEGNLEASKPEDTETEGAEGHATWMSRKRFKAEDFNLEKKIEALPSLSLEEFQAMKKQQRTKKKKILQKVSGSSKKPYRDNSPGRKTDMQKESEKALLVGSQKRKARKQSITRNTLTVDSPIVKEEQEPNKAWCESPDLEALACLAAVAANRTKLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHC4</accession>
    <name>A0A232EHC4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004530">
        <property type="protein sequence ID" value="OXU17760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHC4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12880" checksum="77E0F25706D3448A" modified="2017-10-25" version="1">MRVLKERIKQGREKIERKKQKTEKAEKGKKGAREQKKKNKNTQEAEEEKREEERKKGEAKIEQGEQNYLKSLISWTLAPIFRTTIRMVALIKATIKWRGRATKASLKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHJ2</accession>
    <name>A0A232EHJ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004486">
        <property type="protein sequence ID" value="OXU17826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EHJ2"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18676">
        <property type="entry name" value="PIN_asteroid-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Rad51-like C-terminal" evidence="4">
        <location>
            <begin position="1548"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1137"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1513"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU17826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1698" mass="195631" checksum="FE36D64BF32DCB29" modified="2017-10-25" version="1">MLRPIVTLNLPSTIISKLHEKGFFYVEELANLNSKQLKNFNLSRSDIEKQLQPSQELGLDIWQRETQQEHISLCCSELEAALGGGVQCRVITELSVQLNKCYGGLDGRAIYIDTRSGTCASRFKGLMSYITNQNKFLRDHDLHDTNLVIDGNCLMSQLYRDNNCNYCFGGDYGEYAYYVNEFFDELLECKITPLIIYDGAMEDKKLNTIIKRSQDRILNASVSTSANQLPILPVLAKDTFKYIARKRNIKSAQSTFEADDHIASVAKILNCPVLSFDSDFFIYDVMYIPLNTYKPGIFPNSKGVGFVKRCKIFKTEYFLNSFFKMDKNVLPLAAALLGNDYLSSSIFNNFFSTLKISRKLKKKNLLKNNHSRIEALFRWMQTRSLDNAITSVVNELDPEKRKSVIEVIEVIVNGFLNPSSEMLVPLGYSQQEIDTLMQNISTEQYTFEEVKDFSDKPEKLQDDETYLSCSEDETTTLPSADFLIFKPGSDININGKLPSWFLERCHTSRFPAYFMDMINRRLIVVSEQMEDFSQPSCVNISLKIISSIFRLLHNGITDYKSMKYMTRGSKLNVETYELDCDKYKFPFDIPTLEKLKDFPMLKRKEILTGTLGVNDKLIAEFPPIWRLYIATIKYWFDEADAVFTTTAHVYTLVLLLIHHVIKKVIKDQSYFGLESVNVKNSDEVVDNKQFTNQDLVRDMPVKTALEKVTKQDCLLALKYFQLHKQVKKEEEFKIAVVHSFSLLQSCLKQSINLNALLGHLYPDVDIAEFFSGTLAYNLYNDIEQKKPRYNSHISKVFQDSPSVLQLFVSVSTKMQIMAKQKNPSIIIDGNGVASQLYSREAKGNCCFGGDYDKYAWCVSNFFDELLKCNITPLIIIDGGSEDKKLSTIYKRTKDRVRTACGMTPQKQARTQLFPLLLKEVFKNTVQQKGIKCAQSLFEADDDIASVAKILNCPVLSFDSDFYIFDVMYIPFNTLDFGVVKNPNGNGFMKNCKVYKIDNFLSSFPGMDKTVMPLAATLLGNDYINRSTFKDFFSTLRLSKTSKRRYNEQQRRIEATFRWLQKQSLDSAIAIVLSKLDQKKRKHILEIMEMIINGYLIASPRMLYPLGFSNDYINHLMREMPNKPYKFQQDINNLRVKDEPKADDESDLSCSEDDPPSEELEIVKPENESHLYSLAPKWFIEEFNAANFPSYFIDMLTRQLYVCPVQVEDFSHPTCINISLKILRVIFKLLSAGTTNSNVLEYVARSNVTNITTYKLQCEDHIFFCKFPSLSQLRDLPLIIRKQILDNTLGISDNLLNEFPPEWRLYIATAKYWINEADAPFRTNCHLYALLFVMLYHVIDRKAGFHRSQSYFERKYGQHLKMLYQHRNNTMIYSPAPNMPIFEALNRVDPDDCLLAIPFFLSNFIMDERLLMNPKKFHISSVHGFSLFQNALRHSTHLNALLGFPYQQTNVAELFNGTLIYNLYNNLKTRHDIDVYIRTVLRNSPSLLQLFVSIMATIRSIFTEALETKINTGRRRKNRNRRKNDLHSDDNVLEDDDDFQNDVPYYDDLNLNADEVLKCIEILSPNSVEEFVQIIDSLKFKVKSNKDEKKVRLIIVDSLSMPILCCIDDPTKRPYYYSQILHKLHKLALINELAVVITNELVMQVDKDGKSYFAAAGGQYVADYASVKLEMTRLTDHKFATCLLKSPIMPEIAVTFMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHK8</accession>
    <name>A0A232EHK8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004489">
        <property type="protein sequence ID" value="OXU17824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHK8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="44" mass="5441" checksum="261F3F4A917AACCD" modified="2017-10-25" version="1" fragment="single">VKLLETTSILPTLGTRYLWECCYHYIRVHRPRKRTCDEFRLIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHS7</accession>
    <name>A0A232EHS7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004427">
        <property type="protein sequence ID" value="OXU17917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHS7"/>
    <dbReference type="OrthoDB" id="10249338at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="151" mass="17745" checksum="E082825E14AEFB54" modified="2017-10-25" version="1">MNMKNISTEQCKNRAFDPQDSPYGSRNYDPDVLQLEEKEKLNQHKIVLRHENEAYMYNHPEIRGLVSIMLRRNKISRRHRYFLEKKPSRVEEVQELCAAYFGRPRGTIAAELLDYLLEIKHQGAIVAELRREVASTATEAVEKPLDPEHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EID6</accession>
    <name>A0A232EID6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004257">
        <property type="protein sequence ID" value="OXU18137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EID6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10641" checksum="B9C60C7EC6A12B57" modified="2017-10-25" version="1">MRKVSSMLKVTNDEVCTSHQNSLPSQFSLNNLGSAMHPEPYGFGGKNTADMNSTFICRMMNFDLEYGYLAARGGFRLERHFLFYGGRLASMMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ74</accession>
    <name>A0A232EJ74_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004069">
        <property type="protein sequence ID" value="OXU18419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ74"/>
    <dbReference type="STRING" id="543379.A0A232EJ74"/>
    <dbReference type="OrthoDB" id="7698353at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="510" mass="58932" checksum="51E79AE1EF9BD11B" modified="2017-10-25" version="1">MDYEILQRLPVRYKLEAIISPLHPQTRRNKLSTHSTNILTCKFFETIVKNRLQWWVETQNIIPANQSGFRKGKSCADNLTSLTLKIDEAFSDKKSVPADFLDVNGAFDHVNIDILFKRLASIGCPHIQIFSDLNESPTFVHRGIPQGGVLSPLLYILYVANILSGLKKSVSISQFADNISLYVKCSVINRGKQILENAIKKVKDNLPEIGLELSPSKTKFIHFNNQKILPGSTEILINNISIISSESARFLSIIFNYNIFVNSRKKLKTQKNTKILHQCISNLTSSNVYKITTESNFNLYTNDYHTLITSIPINTSFASKFKKDLDPNKIINDYIIEHNALDFYTDGSKVLGNGAVGCSCYCPTLNLSHYFIQTRLYFYSRIYCDKRFTRFRFTTPKPKYYNLHRLSNEKPWFSSNNSLKRDFNVSIYRSRSGHYNIAESLARINIISDPKCLCNLYFENLNHVLWQCELYEKQRKDMISNLRKIRHYPSLCVKFLICLTINYGLFKEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ83</accession>
    <name>A0A232EJ83_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004059">
        <property type="protein sequence ID" value="OXU18429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ83"/>
    <dbReference type="STRING" id="543379.A0A232EJ83"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47255" checksum="BEAB32EAE902CA38" modified="2017-10-25" version="1">MHAYVNGLLTNFVEVEAYLHLNFKHIVAITETKLSGHDGDAPVAVDGYDLVRYDREGRGRGGMAVYIHKSLRSRILATSDNQEGTSSEYVVLEVSSDRDKLLFSVVYRPPKVTLPHAFFDKSLYLVSDFNCNMLSATLFETKYLADLISSHALAPTPSLVTHDTINWLIIQNLTLHSRMVMTALTLHSRSLDPIPLNGKFSVAIYLVSKIRAISKITLNALVNNNVCELDDSVSLFNALIITSIDKFALLLSIVTRTQQKPWVTQPIRAEIRDRDKIAKRACMRGFSEKTLITPIPKVSPPNDVSDLCPILRLSECSKLQERILSKQLMNYFGEHDLLSPRQVGFRTGHSTQTVLLRPNITNLRHLRLLLKSAASDPEKQKFLATIAFLKGFKDKLKCLLKRGEGVRERQSEMARLRGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKM1</accession>
    <name>A0A232EKM1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synembryn-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003783">
        <property type="protein sequence ID" value="OXU18872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKM1"/>
    <dbReference type="STRING" id="543379.A0A232EKM1"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008376">
        <property type="entry name" value="Chaperone_Ric-8_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01802">
        <property type="entry name" value="SYNEMBRYN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU18872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="61808" checksum="BBC5F72B1DA82D77" modified="2017-10-25" version="1">MEDLFLKLKSENDQDFSQALTTFVNNASYIVLLHYASVTKFEFLDKENFRSEIWEAIFLHLNSKEQYYIHEKCLATLRILSRDKTNLDSILTKEKLNVILEYAGLNIKQEKYTISSVTNEAQKLLCNLLFNSPKIQTTLVETSCLECVIDRISKYNENNCHDTKLFDVRIIFLVTALNISTRNFVCTELHGDIQLIKMLENVLQYYSMDNREIKDNDATLTCEILKALFNLFYQPKDLTTEEMEIYEKLVFILRNLCFNNSKQHKENLISNTVNLLTVIPKNCYSNLIVQLPNNQQDLILYKDVDMSTINILIIFLNNKLECKTNLIENLSPILSCFIRMCKTERLIRKYTRMQVLPPLKDVLQRPEEGTTLRNKLCKLLTTPITEVRDLVAEFLFVLCKEKVGRMIKYTGYGNAAGMFANKGLLGPDHAKVDYSSESEDSETEEYEKYKEKINPVVGCYESPKPNPLEGMTEEQKEYEAMKLVSLVDQLQRKGLIQPCRVGEDGKPKAIEHVLELKEQLPKQQIHRQESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKQ8</accession>
    <name>A0A232EKQ8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003730">
        <property type="protein sequence ID" value="OXU18939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKQ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="99" mass="11140" checksum="F2D4E31B2F80AFD9" modified="2017-10-25" version="1">MGLVHVQDDILASLYDSEIDSDKISEISNSNSEFDNSVNIQTNISIIAKTVIEVKLLMRPKSEFSDIETSIDINSDNESSKNDFESEKEESRDFKSTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL47</accession>
    <name>A0A232EL47_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003639">
        <property type="protein sequence ID" value="OXU19065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL47"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="168" mass="18986" checksum="F59B4617B3A0B050" modified="2017-10-25" version="1">MKQNVTPPVKNDTPSIVMTPHSSSDEYKWAVCHNFNQLSFGSYWSMTNNGSFKMSSETNIPSTSTSPVSDLAKNFKKNMHIKSCSPTQKRRKIKRRLNQICDQISKIKLSPPPQQQNIDKNSLDSFSEATTVKKGSKRALEQPETLAPPIRNCFIILRKSISRSIVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELR7</accession>
    <name>A0A232ELR7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003527">
        <property type="protein sequence ID" value="OXU19252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8046116at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32435" checksum="4178B0072BEFD01E" modified="2017-10-25" version="1" fragment="single">YLNIGRKFRDHGKSHTHIENINAARTSNTFVTVEVEGPSFLDKVHVAEIQTALFIAEHNVGVQLVDDLVPFMHKLCVDPEPVKSMRMKEDKCSRVIKEVLYKSLFDNLKEILSSTFYSILVDESTAIGNVKLLXIGYKSIRLKLRKLLEVEGPSFLDKVHVAEIQTALFIAEHNVGVQLVNDLVPFMQKLCVDPEPVKSMRMKEDKCSRVIKEEILSSTFYSILVDESTAIGNVKLLCVSVQYFSKEQNRVIQHLLQLIELDGKKGTALDIFTEFKAFFDKNHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELU2</accession>
    <name>A0A232ELU2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016192</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003494">
        <property type="protein sequence ID" value="OXU19333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELU2"/>
    <dbReference type="STRING" id="543379.A0A232ELU2"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="281"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU19333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="357" mass="41686" checksum="8FBB655E6775D83D" modified="2017-10-25" version="1">MQTDDRMASASEKLETCEVCAANKAKYTCPKCEVRTCSLTCANIHKRELECDGIRDKTKFIPLASFTDLDLLSDYRLLENIGRSVEQLQNDPTKRCTRLIEQNLPPHFYKLRAAAYRKGVELQFMPHNFSRHIENTTYLVWKTNEIFWRVELIFSQAENAKWVIERVPENKRLSILLEEILNGEGSTETKSSDASSQLSVLQNKLKFYRACGVSGLKAFLKAERVKKSDSRFFDLDLDMTLQENLKNKTVIEFPIIYVALKDHSDMFEIIDSDDEELKEKAERHSNKRNRLNRQRKQMDDEENSPKIEVDSSVNYFFNGDISDSEDELSCPSPERKRYKNNEELYIPDYKELVKMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM47</accession>
    <name>A0A232EM47_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003427">
        <property type="protein sequence ID" value="OXU19426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM47"/>
    <dbReference type="STRING" id="543379.A0A232EM47"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000066">
        <property type="entry name" value="Paired mesoderm homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU19426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="245" mass="27161" checksum="AD2996221D0092F3" modified="2017-10-25" version="1">MLSDTENLAQQAANSHAPQDFTVSRLLSCGTPNQALADCNENSSSGSRRPRRSRTTFSAQQLAALERVFERTHYPDAFVREELATRVSLSEARVQVWFQNRRAKFRRNERSSALNRGSSASREMETTLPLRPIRLNPSHESSNSGSTGDASQHHQLNPYNAYGDYWRSPSVSAAQHHYSAAATTNCNHGFNVTGLPTYHHHHHHHQSVAEAVHSNEMSSSTIGAALRLRSHPYGAAAYSAMHASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMV9</accession>
    <name>A0A232EMV9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003284">
        <property type="protein sequence ID" value="OXU19680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMV9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="151" mass="16827" checksum="8492DAE4F4C7F712" modified="2017-10-25" version="1">MKRNNSSSTTTTTTIRRYSMMRSHANSTSSSSSSDGNTTSHSSSSIESSRSQELNITGVYSQSGEGKGEEENPRFIIESNSTLFYRRIGYDGRGIRGILPEPPMNADFHSRLEGWVRDLHRQLCERSGPSNVIGVTINSEQFSFSQDIHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ32</accession>
    <name>A0A232EQ32_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002864">
        <property type="protein sequence ID" value="OXU20427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ32"/>
    <dbReference type="STRING" id="543379.A0A232EQ32"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="BACK" evidence="2">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14335" checksum="391F010B4A8367B0" modified="2017-10-25" version="1">MKSNVNSSFLEIKDIQIRAFKPLLQYIYTDEINNIDETLAKELIVAAIKYDIKGLATKCEEILCKNVNVSNVIEIFEIADQHNITQLKSQTLEFVADHASVVMNSKKFATKELEQSKSLSIQSPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ92</accession>
    <name>A0A232EQ92_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_009438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01002789">
        <property type="protein sequence ID" value="OXU20559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ92"/>
    <dbReference type="STRING" id="543379.A0A232EQ92"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20344">
        <property type="entry name" value="BRcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20360">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000004">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047555">
        <property type="entry name" value="BRcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047556">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26000">
        <property type="entry name" value="UBA_ARIH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="130"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="134"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU20559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="488" mass="56993" checksum="D35A3F47F443C5D2" modified="2017-10-25" version="1">MSGAECESEMDCSDSDCGDTGYEDYYSTQPWDNETENHIDYNPQHRDPEYAVYECLRVDEVERLLNENVEVLSTNLQITPSLAKLYLHAHDWALQDILIKYQNNASNIMNDSCIKLVQTIESSFNSNFHRSNICLVCLSSLPTDRFSNLSCGHSFCKECWCTHFETQISQGISTGISCMANDCNILAPEDFVLSILTKPIMRERYQQFVFRDYVKSHPQLRFCPGPNCQIVIRSKELCAKRVICNVCKTVFCFRCGMNYHAPTDCNTIKKWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNHMQCYNCKHEFCWMCLGDWKTHGSEYYECSRYKENPNIAHESVHAQAREALKKYLHYYERWENHSKSLKLEEQTLEKTKLRINKKVMNSSGTWIDWQHLFEAASLLARCRYTLQYTYPYAYYMEAGPRKELFEYQQAQLEAEIENLSWKIERAETTDRGDLENQMDIAEKRRITLLKDFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ95</accession>
    <name>A0A232EQ95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002808">
        <property type="protein sequence ID" value="OXU20535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ95"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7644" checksum="8CCC1FB932C0659F" modified="2017-10-25" version="1">MRPVRRRAGGGRTDRERGFTGDDWPERSRDPIASERIDEMISDLKEVKFHCESCIVIPTVDDLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQD2</accession>
    <name>A0A232EQD2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002785">
        <property type="protein sequence ID" value="OXU20564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQD2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="23" mass="2523" checksum="5B289C100425A4D0" modified="2017-10-25" version="1">MCQSVPKCVVFSNLNALAHFGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQF8</accession>
    <name>A0A232EQF8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002772">
        <property type="protein sequence ID" value="OXU20593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQF8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="15745" checksum="98319F5BB6A9CE0D" modified="2017-10-25" version="1">MVGRKAIISHEKILEKLLEFEIFQEDKILKTRTNKWSRISPVPKIYKDGRKGETLQDRWCGLMRDLIWDEKRLPCAFNFHKHSVNCYDAYIKIEGHCTDCNSIINAICEVEPRAGDPVVFKVIATDSRIYRYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQX6</accession>
    <name>A0A232EQX6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">High-affinity choline transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_003448</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002694">
        <property type="protein sequence ID" value="OXU20760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQX6"/>
    <dbReference type="STRING" id="543379.A0A232EQX6"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="558"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU20760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="66785" checksum="E80BB9BD0092586B" modified="2017-10-25" version="1">MINIAGVVSIVLFYMLILGVGIWAARKKEAGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGTAEAIYTRGLVWCQAPFGYSLSLIFGGIFFANKMRQQGYITMLDPLQDAFGERMGGLLFLPALCGEVFWAAGILAALGATLAVIIDMDQGTSVILSACIAVFYTLFGGLYSVAYTDVIQLFCIFIGLWMCIPFAWAHPIVQPLGSMDVDWIGAVEPKEYWSYLDYGLLLIFGGIPWQVYFQRVLSSKSAARAQILSYVAAFGCILMAIPPVLIGAIAKATPWNETGYKGPWPLTETETSMILPMVLQYLTPDFVSFFGLGAVSAAVMSSADSSILSASSMFARNVYKLIFRQRVSINTSILHYDLRSASQNANRGLSQASEMEIIWVMRVGIGVVGILSTIMALTIPSIYGLWSMCSDLVYVILFPQLLMVVHFKPYCNTYGSLTAYIIAFVVRISGGEPIMGLPALIHYPGYDYENKVQMFPFRTMAMLISLITLVGVSYGTQVVFLSGRLAPGYDIFRCVVNIPEDVERVGPDPAEGEQMSVLAAGDGRLYGSKDESNGRVNPALEPDYDMEPGYPAVDQTGSGGGGGGGSAGPTAPTIGSRQAQNSTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER61</accession>
    <name>A0A232ER61_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002658">
        <property type="protein sequence ID" value="OXU20850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER61"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="49" mass="5346" checksum="6EDF85C138045E5D" modified="2017-10-25" version="1">MNNGLQALRVQYDIHVKSLGLSESHRPAFPLKPDVTVSSPELSKPFALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERS6</accession>
    <name>A0A232ERS6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L17, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002555">
        <property type="protein sequence ID" value="OXU21060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERS6"/>
    <dbReference type="STRING" id="543379.A0A232ERS6"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12507" checksum="AC8B3BB7DAF2C9CE" modified="2017-10-25" version="1">MQNGCNKNMMELADYWILEKQLIHKLFNVLPSRYYGSTIYTNLYHSPRQFPGIHYKRAVLELKGNPFPSIVTHSTDGGLLIQNVLLNQAKKEYSSRQYEKTAENITNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESH1</accession>
    <name>A0A232ESH1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002421">
        <property type="protein sequence ID" value="OXU21308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESH1"/>
    <dbReference type="STRING" id="543379.A0A232ESH1"/>
    <dbReference type="OrthoDB" id="7692528at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008593">
        <property type="entry name" value="Dam_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05869">
        <property type="entry name" value="Dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="193" mass="21971" checksum="CEAC3915D61A29E9" modified="2017-10-25" version="1">MGGVRYEAYNRLAKEIWQWAEERHISLFASYIASSENTEADRLSRLVNLDIEWELHDSFFVVIENVFGRPDIDLFANGSNAKCATFYSWRPEPGAVGVDAFTMDWSGLNFYAFPPFSLILKTLAKIRQDEASGILVVPFWPGQPWFPLFESLLINQLVFGPEANLLLSPCRKKIHPQAEHLQLIVGRVSGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET14</accession>
    <name>A0A232ET14_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002347">
        <property type="protein sequence ID" value="OXU21494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET14"/>
    <dbReference type="STRING" id="543379.A0A232ET14"/>
    <dbReference type="OrthoDB" id="7695744at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6542" checksum="4BD322EE265A30E4" modified="2017-10-25" version="1">MKLSVSAYRAQASAHKKILSNYQHQLSYGATNQATSARTPSDPAAVLPGLKTIEYWGAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET50</accession>
    <name>A0A232ET50_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 57</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002329">
        <property type="protein sequence ID" value="OXU21538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET50"/>
    <dbReference type="STRING" id="543379.A0A232ET50"/>
    <dbReference type="OrthoDB" id="1728874at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000230">
        <property type="entry name" value="Leucine-rich repeat-containing protein 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26959" checksum="FD280B02263084C6" modified="2017-10-25" version="1">MGNTGFKEHFEVAKKTGTLNLSRRKLDEFPQQLASLVSLLRTLDLSDNKFSKLPLDIGKFTLLKQLNVSGNRLTELPDVLGNLLKLETLNANSNQISVLPASLSKLSHLKMVNLSDNRITAFPLMFCGLKHLDVLDLSHNRLTSVPDGVAELHVTELNLNQNQISEISEKIADCPRLKTLRIEENCLQIKSIHRRILEDSKISNLAVEGNLFEMKQFPDLDGYDKYMERYTAVKKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUD2</accession>
    <name>A0A232EUD2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002136">
        <property type="protein sequence ID" value="OXU21969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUD2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="193"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="241" mass="27862" checksum="E02F97A04D802598" modified="2017-10-25" version="1">MSKRKSENSANCEAKKKNISTLVAYVEQIVDEKTFTNKVKNVDFTIKKVILNNNDDVKIQCNLYNEIIDVFSANLKLNEKILIRNATAVSAKAYTKGNLTFEINLQSFTTITSLEEFEWKNVNIYNIDFDEIPTKIGFLTGFLFNEFTQRNKTNENEYFGSITNKKNKSDILLHKTKNESIDYELGCKIDVTSNLQENVMKEMLRFIYTDKANIESLPIMDLLAAADKYQQRSLRRITGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUG9</accession>
    <name>A0A232EUG9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWI/SNF Subunit INI1 DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002138">
        <property type="protein sequence ID" value="OXU21957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUG9"/>
    <dbReference type="STRING" id="543379.A0A232EUG9"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21086">
        <property type="entry name" value="WH_NTD_SMARCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048664">
        <property type="entry name" value="INI1_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017393">
        <property type="entry name" value="Sfh1/SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21459">
        <property type="entry name" value="INI1_DNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038126">
        <property type="entry name" value="SWI_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWI/SNF Subunit INI1 DNA binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="393" mass="45167" checksum="62B2F22880D99134" modified="2017-10-25" version="1">MALRTYGDKPISFQVEENGEYYCIGSEVGNYLRLFRGSLYKRYPGMYRRSITNDERKKLVELGLSQHVLASSVSLLRASEVEDIIEGNDEKYKAVSVHSTEPPAPREGKTKKPMSWVPSLPNSSHLDAVPQATPINRNRVHNKKVRTFPLCYDDTDPSANLENATQHEVLVPIRLDMEIEGQKLRDTFTWNKNESLITPEQFAEVLCDDLDLNPLTFVPAIAQAIRQQIEAFPQEAILEEACDQRVIIKLNIHVGNTSLVDQVEWDMSEKENNPEKFAMKLCAELGLGGEFVTAIAYSVRGQLSWHQRTYAFSEAPLPTVEVPFRPPSEAELWAPFLETLTDAEMEKKIRDQDRNTRSNKKKDRKWQSSQNHSFFVLHRVFMKNFNKLKYYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUS8</accession>
    <name>A0A232EUS8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002100">
        <property type="protein sequence ID" value="OXU22086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUS8"/>
    <dbReference type="STRING" id="543379.A0A232EUS8"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000008">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000060">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF90">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="169"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="360"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="653" mass="72464" checksum="5220DBA1AA1A437C" modified="2017-10-25" version="1">MSPRRLKTLTRIFGELRSGRFSTVVQTNARPEAMEDRSDGNTFGWIYDPISHRLQYRSIAEQNQVVSSSGANCQTPQRKMFTFERDQLGQRPADGDTSTPGLVRGLDHVRNPQLNKGMAFTIEERQTLGIHGLLPAAVKTQDEQLELCRLNLDRYTDELSKYIYLTGLLDRNEKLFYRLLSEDVEKMMPLVYTPTVGLACQKFGLIYRRPRGLFISIHDKGHVYDVLKNWPEHDVRAIVVTDGERILGLGDLGAQGMGIPIGKLSLYTALAGIKPHQCLPITLDVGTNNQAFLDDPLYIGHRHKRVTGPEYDAFIDEFMKAAVRRYGQNTLIQFEDFGNSNAFRLLNKYRDHYCTFNDDIQGTASVAVAGLFASLRLTKTRLSDNTIVFQGAGEAALGIAWLCVMAMRKEGVTEEEAKSKIWMVDSKGLIVKNRPSGGISEHKAQFAREHAPVDSLAEVVKLAKPSVLIGAAAIGGAFTRQILEEMGKINARPVIFALSNPTSKAECTAEEAYNATEGRAIFASGSPFDPVNYGGKMLYPGQGNNSYIFPGIALGAICAGMKTIPEEAFLQAATTLAEIVTDTDLERGTLYPPLKDIQKCSISIGTKLMDYAYAESLATIHPEPDNYEEFIRAQLYDTSYTSSIPPVYPWPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV29</accession>
    <name>A0A232EV29_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002063">
        <property type="protein sequence ID" value="OXU22193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV29"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14257" checksum="A5F0CE09E1E24717" modified="2017-10-25" version="1">MTLTKVEVGKGGHQMTQHPMTLNSIFKKQRRRRNRIVFPLGYLIRVSPLASHFLGCLIRVSPLASHFSGCLNRVSPLASHFSGCLIRVPKDTTIFLDSIQFLGCFRKRIFILSLALLRNDVDTIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVM0</accession>
    <name>A0A232EVM0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001975">
        <property type="protein sequence ID" value="OXU22403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVM0"/>
    <dbReference type="STRING" id="543379.A0A232EVM0"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="70368" checksum="4566657559780BC3" modified="2017-10-25" version="1">MLQLLTKKSSNSLRLQKTKILISKYKNCKFSTKPSSAAAVVEKQDEENVMSPPISLLNQRVSTSEASGNASFILSQLNSLPEKDAIQRPLDFAVLRNVSELDDSPLPFEEVPGPFILKLWEKYWKYVPLFGTQLIRSVLINRLTEGRLQWNRNVTPIRYLFDEYGPVVKLKGPFAGDIVLIHRPEHIQKVFNEENDYATRSAIDILQHYRLNYRKYRFAGPYSAQETQGLQWLKIKKSLEMPIKKQINNQFAKLEITCDELLQRIRLMKNRQDEVSGNFNQELLRWGMESFWIILLNKKLGYLESTGYSETSEASRFIDALSTAHLYMSRCETGFQVWRFMETPFSKKLFNSCDVIDETIEKYIRIFQSSRLHESPSNYNKNENICSSITENLLVDHSMNPDEVSTLLMDMIILGVQAAVNSQAFLLYFLAKNPRVQKRLFNEIISKTKDYPILNKETLEKMPYLDACIKECLRIRPPFPYLTRLLPKDIILHGYKIPKGTYLIMANQITSMREENFEDPEKFKPERWLQNDDSFSAYSYLPFGKGLRSCMGENIAKLEMMLLTAKIIRNFRVEYEYSEICSRFLMMNVPNRPLRFRFVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVX6</accession>
    <name>A0A232EVX6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001940">
        <property type="protein sequence ID" value="OXU22493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVX6"/>
    <dbReference type="STRING" id="543379.A0A232EVX6"/>
    <dbReference type="OrthoDB" id="624114at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059005">
        <property type="entry name" value="LETM1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26561">
        <property type="entry name" value="LETM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="270" mass="31004" checksum="3E7FD8A925633E1C" modified="2017-10-25" version="1">MSVEKEEIKELKEEMAEYQEDIQELHQLKAEASGLADIEKIKVSKGANRLFNKVNRMINKMDAVLVELEQSEKRIKEEMNTLYSEKKDKSHVAAELVKIDELIAAIKQIQNVPDNRRLSRITEILGKIDDDRDGAIKIEDVLKVVELIGKEDIKLNKKQLNELIELMEKEEVLEVEDQIQKALTKENKVFEEDKIEDIFESFTNTSTSTVPTSMTKKEDNFKDKEIKNNPNENENIVQSSLLKNTNTIHDNSLSPNTTPTPQKIKGSKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWC7</accession>
    <name>A0A232EWC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001881">
        <property type="protein sequence ID" value="OXU22655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWC7"/>
    <dbReference type="STRING" id="543379.A0A232EWC7"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="32"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU22655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="511" mass="57032" checksum="C85180D5B1041A2A" modified="2017-10-25" version="1">MQAVSVADEPRVSVTTFEKAMQKKVFWSQHVASVTLSLVMFLVGLANGWSSPYLAQLSLQDEVDGIPRATDKQLSWVATLMNFGRIFGAMAGAVAQDTIGRKMSLCFAGIPLMCGWTCIAVAVSVEWLYVARILCGFAMGMIWTTLSLYLSEIADPEIRGSLASRPLTFFFSTTTDMSIVAKSEWVVGRTVVRTLIFITSHVLWNITTQSIGLFLGNLMGPYISMKVYAYISLVPNVLFLLLFPLIPDSPYRLIMIGNLDKAEKSLRWFRRRQDVKQELLELQDYVSTSKVSLVERLKEFKEARYRRSFLMMFLINIFSYFGAFNVINNYMEIIVTKSQVSITPSIIVTVTGGFSILSGLLSTFLVDRLGRRFLLIGSSLGMALSLTALGLHFRLLDLGYDPVYLTWLPCIILLVYTVSYSAGCGCIPSALVGELFSPRLKTIASLSFSGTSAVFSTMSTGSFVPFLNLVGPSYLFWFYSVGIYVSVVYYWYFVPETMGKSLQAIQTESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWN0</accession>
    <name>A0A232EWN0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001836">
        <property type="protein sequence ID" value="OXU22757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWN0"/>
    <dbReference type="STRING" id="543379.A0A232EWN0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="317" mass="35677" checksum="DC8C9C568CD49562" modified="2017-10-25" version="1">MHLESFGPVTTEITQKDANSQSRFKAIVPNKREYTDDLYCPDKEAELTTLLDHFVATPFSFDSCDFCGCVWEENQYLINFDYDLADARSNKIITGATLRVLWNTINIQIQQVTLSVNGTIDESTVERIPVTNKTSAKTVPISWDGIREINLGSILLPAKRVLAGHKFNKTGLNRIVLSSYSHEFDFATEKLKLSSIVNFTGYQDYSINGTKQNYPIPDDNKFIKFQLSSLAKDGEQTTIPFIDTQAVHTKIPSPLSGIGLILRNRRATEVSLLSNSTPSTSTHSLAKRLISTVISLLREKFLCEYPSKKIVYNQKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWX8</accession>
    <name>A0A232EWX8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methenyltetrahydrofolate cyclohydrolase</fullName>
            <ecNumber evidence="2">3.5.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.9" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001812">
        <property type="protein sequence ID" value="OXU22848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWX8"/>
    <dbReference type="STRING" id="543379.A0A232EWX8"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000189">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF11">
        <property type="entry name" value="BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="8">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="9">
        <location>
            <begin position="165"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="327" mass="35336" checksum="FC26638D4563A3E2" modified="2017-10-25" version="1">MSVFKILRPLANQWASRGLHTTNRVCDAAIIDGNGVADQVLEEVKAEVDEMTRNGEKRPKLIAILVGNNPASKAYVGRKVKAAKTVGIDSETLRFEDSITQEELLHEVQKLNDDPTVDGLLVQLPVPEHISEREVCQAVTPTKDVDGFHLSNIGNLALNNKGIIPATALGVKELIVRSKIPTFGKNAVVIGRSKHVGFPIALLLHSDGNGETAGLDMTTTICHRYTPRVELERYTKLADIVVASAGVPGLVTKEMIKPGACVIDVGISRIKTSEGKYRLVGDVNYESVKTVAGHITPVPGGVGPMTVAMLMKNTLFAIRLRKSLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX47</accession>
    <name>A0A232EX47_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_001091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001797">
        <property type="protein sequence ID" value="OXU22890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EX47"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="2034"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1305"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1375"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1537"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1656"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="826"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="972"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1143"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1221"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1427"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1538"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1656"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1674"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1739"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1765"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1777"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1797"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1804"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1816"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1855"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1872"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1879"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1891"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2268" mass="247388" checksum="535A6936BA4FBBA0" modified="2017-10-25" version="1">MSDDGGGGTDNPAFSNDEDTTSCNNSTSTASAGHSNHQSDSETGKNETSHLENGKNETRIELPEDNGKPKQNGVNGNGNNNDVSFLNTSVTSVSNNDVTDKKEQIEAVNLELVSMKPYAGKNNLQTKNHEALEVPADPYEEYFVPVNERRKCIRGIFYWLLYDPKISRSPDTEVETTVAGVRFDLGPGVGREGLSLRDPAAGLVDYSHWLTALRGEKLYVTKDKRSTGSYWRRVLCWGCGLLIVAVIAIIAILAGTGVILTQEATQPLLNGDKTSSRQLNDVQTAGSQEYIKNPPPSPPPATSTFPPWQTTDETLYKLVPKALDGVIKLDDLEWNDEMNDPKSRVYRDVARDIESSLVNMLRLDEGMPLVKVYSISKDGEVKFRVSQPVFDKPLDTQEYLEHKFRLNGNSVSKYHVNRLAFDSLVDQCQSGSMGCSDSCVYDYVEAIFVCSCPEGKVLDESGKQCVVSMELSNVNFEETMTEDVQGRSRIHDDVYHTDDHHWQDPRHGLHHEHDESTRKTESKVDPSAEPKSEPEPAAEPKSEPEPSSEPKSEPEPSAEPKSEPEPAAEPKSEPEPAAEPKSEPEPSADVTSASEPTAEPKSEPEPSAEPASDLEPVSEPKSEPEPSAEPSSDSEPVSEPKSEPEPSAEPKSEPKPASEPEAEPKGEPEPASEPTSDSEPAGEPKSEPEPASEPSAEPAAEPTILPESTAESKSEPEPATEPEPASEPEPSAEPTSDLKSHAEPKSLAEPSIELEPTAEPKSEPEPSAEPTSESEPAAEPASQPEPSAEPKSESEPTDEPASEPEPTAEPTSKPEFEMEPSSEPGSTEKRKNELKPTNDFESIVESKSKAKSESEPKSEPEPAAEPEPSAEPTSEPSHSADSKSEVEPADQPMSDSQPSAEPKSESDPISEPESNIEPVAEPKQEPETVAEPTSDSEPISEPKSEPEPSLESTPEPKSEPEPVIETVSGEKSSAEPKSESSVKDSSEPLSEPKSEPEPVTEPASEPEPSAEPKSEKEPSSESAAEPETSAEPKSVSEPSAEPEPVAEPTIQPESSTEFVNLSVSTSEPTAEPSASSAEPPKISEELADEPNSESESSSAAKHDETTDNQVPDENKTEVPTEPSSEPHNETLDTKKVTDAASISNVEVSTTSTSEPVTVIGLDEDKEILQMIETTEINRNKHTSTETPLNIDQGFVKKAPRLDKDEQDNPNPIESNVKDVESSSVEANVTVTAASDSLNDVPDDKNKEADNSLSKENPEDQYNDITDELVPKGYGQNDIESSRDVKKDEKKIQKVYKEIKIIESVKPSATESPLDKHTDDPNMTSQVPILPIEIQNDMSTTETVEKLEAQATSQEPDKEIMLTTTLSKLSSVEAKTTEQIPILPEELQTTDANKQEHAETTADYTIGKRIDEPTEDVDEKDEDKLHASGTSESVTTSINLGEEIPDRTTMNYNVLLEKSDTMEDIKPVSESIADDTTPQSFEYVFQVTTTTEKSMTPEEYEELTEEQLRVVPLEEREEFKKPSDDQQMKIKKEKELNLEASSELANNAPTKSSRTVEDDNIPKLTFGVSESETNTKSVAHTFDADIKIINKPNNTESSTSSSSYPNIIPVSEDLEDDYHFTEPTILLTFNNRLATTNMPESTINIENTQNVSEVTTASSPAVEVSSTENAANATKTDETTKEPEKKDEVQPEILGIPVAILTSQDETPPVFFSKCKSGQFQCVNGTSRDGAYCVNLSAKCDSENDCSDGSDEVDCEQKGCPGNFQCASGQCLKRHLVCNGIVDCDDGSDEKECSQWKCIFDELQCPNGRCIPILWRCDGRPDCENHVDEYSCSESCGNDEYLCPIEKWCIPQTWRCNGVSECVNGEDEKLCECAIDQFKCDTGGCIPAEQLCDGVEHCPDRSDEWNCLGGFSKNTTSSTEVDKENKENEFATRSSLVKIRQSSGDGRFVCSDGWTDEFSDQYCRTLGFASFEVTQFVEQGSNQNLLQLTPNASPNSSLVINLEKISACKSEKIVEVSCQEFSCGSHESVGPTARLVGGTPASVGQWSSVALLKEPKHGAACTASVLSPMHALASYSCVHRFKQSSGWQLFVGGNLLKPYTVKDIVPYPQVKYNQFLYNNDIALVELAEPLTFSRNVSAVCLPNQSFQPRQLCVTAGWGFPVNGEVDLQQYLKFLPVPTYDSEECNATSHYAGFITKNNICAGFTDNDKGPCYNDEGAPLMCVSETGRWEIQGLLSHHSRCSRGHPAIFSSLTPALSWLRNSVPALQANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY23</accession>
    <name>A0A232EY23_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016973</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001707">
        <property type="protein sequence ID" value="OXU23170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY23"/>
    <dbReference type="STRING" id="543379.A0A232EY23"/>
    <dbReference type="OrthoDB" id="408511at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013053862" description="TM2 domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="10">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU23170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="188" mass="20878" checksum="108BBE8147AC4027" modified="2017-10-25" version="1">MRLIELLLGCAILLSWPGPRDCLIVMAVNKTTDPQPEYRPEGPLVLCKFLPKEFIECDDPIDHKGNKTAKEEVGMGCVKFGGSKYEDVEKTKVFCTVLPDIECHGCRTFLREGVPCIKYSGHYFTTTLLYSILLGFLGMDRFCLGQTGTAVGKLLTLGGIGVWWVVDVILLVTNSLQPEDGSNWNPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY82</accession>
    <name>A0A232EY82_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001665">
        <property type="protein sequence ID" value="OXU23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EY82"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF111">
        <property type="entry name" value="CHASKI, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="235"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="929" mass="102891" checksum="F0B5BFAA5FB1D228" modified="2017-10-25" version="1">MADRNRNFLSRDSINEHNNHKAAKIVANNNELPRKEGLYAKKENSNYQRFVDYPKNELDTPSKKAPIVGWQNGSPTLFPSSPEEHHASGVSAPVVRPLVPPXXXXXXXXXXELEQLDLESPADSEYRPPPTPGEDGYLASPNLSGRGXXXXXXXLPAGSPEKGGGGILVKRRYSEQDSAATLVQDALRGNEKELLNERDSIDDSELMLEIYDDEDDNSTEEDSKKKPKIPDGGWGWVIVCSSLVISMIADGVSFSFGLLYIEFLDHFQESKANTAWIGSLFMAVPLLSGPIMSALVDRYGCRKMTIAGGLISGTGFVLSSFANSIGVMYLTFGVLAGLGLGLCYVTAVVSIAFWFDKKRTLAVGLGACGTGIGTFVYAPMTTYFIQEFGWRGCVLLLSGTFFNMIVCGTVMRDPEWWILEQKKQQGLTSPKKSGKGANGPKLQDGMSRSQGSPTDEDFPGVEELRRLMKSGKAPEYLLQNLRTSTETRVNSSGNPAFRSVVNLPTFVRQSEKVPLEVLESLSSNSRLYNVILENYPSLLFCRSASDKKLDESNGDVNNKSGVTMSMRLKQAKDKGKKQQSSRSGSTHASTKVLAARRMSRKDLEEANPLLAKELAQAIAEAERAKSVSRHHLPGCGAGVVRTDSLPWLRRQFSTNTHYFKDIRVHRNSVMYRGAVLNLHKYRLRASSCPNIYRNSMTTLAKENEEKWYSELVDLMKGMMDFSMFSELHFLLLSLSTILLFTWFIVPYFYLAEHLSRQGYQESQSANLLSYIGITNTIGMIALGWAGDQPWMNVTKTYTCCLIACGISTILMPIFTHNYAALVVICCCFGLFFASNFSFTPVILVEIIPLERFTTAYGLSLLCQGIGNLLGPPLAGWIFDVTQVWDPSFIMAGAWIIVSGLLMGIIPYTKNRKIWGSGPVEIDRERECFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYA0</accession>
    <name>A0A232EYA0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001656">
        <property type="protein sequence ID" value="OXU23305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYA0"/>
    <dbReference type="STRING" id="543379.A0A232EYA0"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12649">
        <property type="entry name" value="RRM1_SXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000383">
        <property type="entry name" value="Sex lethal, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="167"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="320" mass="36435" checksum="8A911C7839BC5234" modified="2017-10-25" version="1">MVIVNGNSGSSQVHQTLPVNSSENATSTPSFQQDEEKSIQEDSKMNDQQQQQQQQQQQQQQQQQPQQQQQQVQQSRNDDRTNLIINYLPQSMTEKELYSMFVTIGPVESCRVMKDYKTGYSYGFGFVNYTKAEDALTAINTLNGLQVQNKRLKVSFARPSGEEIKETNLYVTNLPRNITEKQVEEIFSKFGQIVQKNILKDKLTGLPRGVAFVRYDKREEAQDAINQLHGTIPEGGSEPLSVKIAEEHGKQKAAYYAGWQAGYNQSRALLEKKINIAMLEDELGDLRLSEPMKHPVNKPHRRSNHFAGSSSKSSFHDIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZP4</accession>
    <name>A0A232EZP4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001474">
        <property type="protein sequence ID" value="OXU23845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZP4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10206" checksum="567935988896AD1C" modified="2017-10-25" version="1">MQRHNLEGIHTTLTFCISSTFSIYPTKIQVYVLLCFSFVRFSFSQDDDGDELLSHGGSSVSPRIVEDPVALFQPAIVRRLNDAQRFLLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZT4</accession>
    <name>A0A232EZT4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_014543</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001458">
        <property type="protein sequence ID" value="OXU23902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZT4"/>
    <dbReference type="STRING" id="543379.A0A232EZT4"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000005">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000032">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="301"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU23902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="589" mass="66745" checksum="F69D0D9EA85BCBE2" modified="2017-10-25" version="1">MPTVNVKRDLLFKALGKTYTDDEFQKLCFAFGLELDEVTSEQQMIAKEQGIEQTQGASDEILYKIDIPANRYDLLCLEGLATGLLVFLEKIPIPFYKAVKPKNVQRIEMKKACLQVRGHIVAAVLRNVTITQSAYDNFIDLQDKLHQNIGRKRSLVSIGTHDLDTIEGPFTYDAKPPKDIRFKPLNQDKEYTGEEIMDLYAHHAQLKQYLPIIKDSPVYPIIYDKNGVVLSLPPIINGDHSKITLNTKNIFIECTATDLTKAKIAVDTIVCAFSEYCSSKYEVEIVEVIYPDNKKFDSPDLKYRVEKISSKRATNYVGINQSPEQVAKLLTKMSLKTEVKDGDELHVQVSPTRHDIIHACDIYEDVAIGYGYNNIKKTIPKTPCIGKEFPLNKLTDQLRETMANAGFTEALTFSLCSREDIADKLGHDIKHVPAVHISNPKTLEFQVGRTTLLPGLLKTIVANRKMPLPMKLFEISDVILRDPKAEVGARNERRLCVVYYNKMARFEFVHGVLDRIMHILEVPWHSNKDNKGYHLRPLEDPTFFPHRCGEIVAYGNVIGKIGTLHPDVLTKFGLTIPCTSLEINIEPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZZ8</accession>
    <name>A0A232EZZ8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001425">
        <property type="protein sequence ID" value="OXU24014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZZ8"/>
    <dbReference type="STRING" id="543379.A0A232EZZ8"/>
    <dbReference type="OrthoDB" id="7691871at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="379" mass="43264" checksum="397A121EBF2BA638" modified="2017-10-25" version="1">MFSGRRVGETERLKKGNFSKIERLESNNDGSRKLSYGEIEFLQSFRRILIRGKLNRTVPLLMTDKDEEAINLYMSFFKVEEANVDKNNPYVFALPGHTYKHQRACDNIRKYTSSIKNLKHPERLRGTLFRKNISTIAMSLNLSNGARTDLYDVLGHSGKINKNIYAQHEFQQQILTIAPILLKASTAVNKLDEQKCENDDEEEDIIQYETIIPDMNAKIQILERHTDKPSKLAKGNEERLESNNDGSRKLSYGEIEFLQSFRRILIEYESYIIDKRIVDNYQTFHRKTSALLLIKDQVTCKSSGTMSSWRNVSGGMSPGEMSLEVGALLPARAPDVNCRCRLLLESSPVSPLAGRRAVAMATREFWLQCDSDLGDIAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F005</accession>
    <name>A0A232F005_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">chymotrypsin</fullName>
            <ecNumber evidence="8">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_015806</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01001457">
        <property type="protein sequence ID" value="OXU23909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F005"/>
    <dbReference type="STRING" id="543379.A0A232F005"/>
    <dbReference type="OrthoDB" id="6755574at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008738" description="chymotrypsin" evidence="10">
        <location>
            <begin position="20"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="318"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="550" mass="59401" checksum="D061417F93F53AAB" modified="2017-10-25" version="1">MGFGVASIACFVLFVGALAGPVKRIIDGKDANISEFPYQVSLRKEGKGHFCGGSILSNRHILTAAHCVNDIMKAPYTEFSVLTGSTNSSGNNGHVHKIETTHVHEDFLRTSESAYKNDIAIITLKEPIEFNENQKKIDLPSKDSSHRDNAVVSGWGIEKNQVKIAAATLKKAHMAVIPSHMCAMMILRPLQYETQICALYGNNVSICSGDSGSPLASNNEVIGIVSWSTSCGIGLPDVYTKKLLLVLLAVLTIATLCAANTCDVEVYNTDFKCKNKDQCNDVCTARLKRFDCFLVDTECHDERTCICRGAFAAPAEKIVGGGNADITEFPFQVSLRLRGKGHFCGGSIISERHILTAAHCVDGIITPLLKNRFSVVTGTTTSSGSSGKSHKIKSTHVHEGYLGTDESSYKNDVAVITLAAPIKFDAKQKKINLPTKDVSLGDKVMVSGWGIKKYPSEIVAATLQKASMKLVPSSQCEQFLYPQTLYSTQVCAIQKKGVGVCSGDSGGPLAADNEVIGIASWVVPCGKGFPDVYTKVYAFKDWIKNIIDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0P5</accession>
    <name>A0A232F0P5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001403">
        <property type="protein sequence ID" value="OXU24093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0P5"/>
    <dbReference type="STRING" id="543379.A0A232F0P5"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU24093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="21098" checksum="1CCEEF1322A482E8" modified="2017-10-25" version="1">MTEIDWPWQYSFPPFFTLQPHAETRAKQIAAWKNLVLNYFRTTKQAILDIREIHSTPLFNNVSIDSILSNDEFRKLPSEVVSVIVEELAKSGNATPLDKAKLRWIVSWHTLDEWADIIYSWAQTNGFAGSVCTFYELTQGENTVDQEFHGLDNELLVRALKTLEAAKRAELIIFDDNEGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0T3</accession>
    <name>A0A232F0T3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001371">
        <property type="protein sequence ID" value="OXU24202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0T3"/>
    <dbReference type="OrthoDB" id="7700068at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="252" mass="28728" checksum="B91FA2205D4CEAEA" modified="2017-10-25" version="1">MEIKVREFIPAEAEIPAGDKKKEDAGKVSTEDAAGMGAESTTEELAVVQEMNEVREKVRLERIINEGLRRYIEQVKKERIMDKNRMNELELVIEELLEKGRDTLGKEQNVENNNNNNEEKESVRGDGAGEKEEGELDIGNSEEENNNNKGGGLGNIKRNYLKKVRAIGGGLVVELESMENKIEVMRKRGMLKGMNVWIEDDLTERDKEIQNWLKMIAEEERGRGLETQVAKTVFSCDTRYLQILNQYESVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F148</accession>
    <name>A0A232F148_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_001210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001377">
        <property type="protein sequence ID" value="OXU24177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F148"/>
    <dbReference type="STRING" id="543379.A0A232F148"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16692">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039456">
        <property type="entry name" value="WDR59_mRING-H2-C3H3C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="432"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1000" mass="113614" checksum="C43D3D75A6615B09" modified="2017-10-25" version="1">MSKHWGRDYVVTEHRDLQANTMAVDVTGNHVLLAGRRYLAIKHLDEEPLRKFHRQSKYEVGSAEWNPNLANCHLCAISSNTRVEILSFMGNNGYELQPTHSLRAHTRVVSDLNWHPKDPDILATCSIDTYIHIWDTRDQRKPSLSLSAVGRFYCLNKSFITVHFLFLCHIGHYEYMLILAGASQVRWNVLSPNMLATAHDGDIKIWDQRKGNSPVQYIAAHLTKIHGLDWCPFQQNQLATSSQDCTVKIFDTNNPRRAESILTTNSPVWRARYTPFGEGLVTIVVPQLRRGENSLLLWNTSNLSAPIYTFDGHTDVVLEFQWRQPRSEKNDFELITWSKDQCLRIFKIPPLLKKLCGHDMDDGNCVYTQYSGDSNMRILQSVQALQLHESNNEQQLTYPATNMDTTVSNQEDEVSKLEKEAPSPTQPKTLQQEFSLINMNIPNIEVNAMDAKERTCTVTASNKNYNVVLKVNFPGNYPYSAQPTFQFCPGTNIDNAIMTNLLKVLKQTAQQRVRKNRSCLEPCLRQLITTLDQTCIKDESEKNHLEYHMQHTENFLNSNKICSNYQDAYIPFPRTSGAKFCSVGILVCFGRSSYARRTSVKPDGATPRALSALGSSVNNNGGHFMQIYPHSYVPPDNITISSFYFEERITRKNAHTFNRSHGKPGFKNYHSLVTIYDASSLFFVNKELAEKYVINTTDISAMCQANANIAASLERPDLVQAWCLAALVISQPLTNAQNAQGTYQSPDTDAPWSLHPFRQNLIHSLIQHYANQSDIQMAGMLSCAFSCRSENSDMLQSRFISKSVNVSKLFTGKWWLKPGGSPYHTIHPADTSLEGWNFPNLKQNRSNSWSESLDGLQIQDTYNEYGRNIRLLDEKNTALYDAYKKAYAEVLHRWRLLDARAQVLKHVSTTSFDTHKSIEFQSECLTCNKSSKGPQCSLCKRLTFQCVVCHISVRGPSNFCIVCGHGGHTYHLASWFKNETVCPTGCGCYCLQENMLLLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1I0</accession>
    <name>A0A232F1I0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001262">
        <property type="protein sequence ID" value="OXU24574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1I0"/>
    <dbReference type="STRING" id="543379.A0A232F1I0"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="174"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="595" mass="66043" checksum="AF04F20C656C953F" modified="2017-10-25" version="1">MESFLDLFDTGESKPRRSKSWDDSENEENDTSDSSNSSNSTFEDNEERLPPEPEQGNVEYKLKLINPSSQRFEHLVTQMKWRLQEGHGEAIYQIGVEDNGKLAGLSRDDMKASLKTLRDMAARLGATTNVLRERSTHPKSNNKRAKAKNNKSEEKRVAEVLIRKIRKDDREECVIDLRLAVMGGQDAGKSTLLGVLTQGELDNGRGRSRLNMLRHLHEIKSGRTSSISHEIIGFDNEGHVLNYAELTTAEEICEHASKVVTFIDLAGHRKYLRTTLLGLTGYSPHYVMLVVAPPVNEVVQEHVALCLALRLPFFVVLTKVDLGYCDPRETINQLESIARIQGCNKNFVLRSNNNGDAQSNDADIIPVFPVSCVTGEGLDELTRFIRDLSPMDTVPPDSDPDACLFQIDETFRVAGSSEPVLGGLLVKGAIALGTRLLVGPSPKGEFSPVKVVSLHRNKAPCCFVRASQSASLTLAPPTKRDPPLPHLRPGMVLVSIRDHPRATLFFQATVIVVYHATAIYPGFQATVHIGNVRQTCVIEGIMEIKKGGLQTNDTASVLFRFLSHPEYLHVDMRLLLREGRTKAIGKITQVFPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1I7</accession>
    <name>A0A232F1I7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_008666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001260">
        <property type="protein sequence ID" value="OXU24581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1I7"/>
    <dbReference type="STRING" id="543379.A0A232F1I7"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001909">
        <property type="entry name" value="WD repeat, SAM and U-box domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="900"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="369"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1148" mass="132042" checksum="75CDED2B0393BBCA" modified="2017-10-25" version="1">MQVSNPNDVKIYNLSAGKSLPEWLSERKRRNLVKKNIDIRRRIELIQDFDMPGVSTSIRVSKDGQYVFATGIYKPRLKCFDVNQLSLKFERCFDSEVVTFEALSDDYSKLVFLHCDRHIEFHAAHGKYYRLRIPRFGRDMQYHYPSCDLFVVGASNEIYRLNLERGQFLQPLISESSAINKCTINPVHNLLLVGNDEGKVEAWDPRVRNKVGTLDCGFSCIKQDNKLDTVPSITALKCQGGLTLGVGTVTGQVLLYDLRSNSPFMIKDHMYGLPIRNIEFHKSMDLVYSMDSSIVKIWEKQTGKIYTSIEAQSDFNDLCIVPNTGLMFMANENTKIQSYYIPSLGPAPRWCGFLDNLTEELEELDYETIYDDYKFVTEKELDELGLSHLKGTNLLRAYMHGYFMDVRLYRKARDVMKPFEFEEYKKKKIREKIEEERPKRVQVHKLPAVNKDLALKHLDNEETTDPKKKKKATPNLLKDDRFKALFENPDFQVDPNSEEYALLNPVISQMGKTKKRAASKVQVKEDNVEYDDAENLHSEDEDMADSSDDEKPWVKEVQKQYRLVKESEKKLEMEERRKKEEEEENAEGPKKQPKFYELKDGVSYNGSKYMRKRAKASLGDRLQKEESHRISVSGSRGNKEMTFTMGKQNFGKKGGQNKTNRQDFKHLLRPAKNIGKALSCYNNACKFSIIVQVIMKASPYNNASSNGKENSSQQNNDEPSQSTPSTPSLLSDLQLHSTEMGEIAEMPDYENLSTSAVLHYCKYKILRPYLRLLGVMGLRPNSEESERISRYCILSNFHTFQVIVFMCIGYVLQRDRGFCYVATSLESEITTKPRTYEKTCHGNAIFAYFIPNGLHLIAYLYTVYLFRVKENEQLQNLMERAFLLSSNSANRGGQKRLVRILWLFIGLGVVWMILALVAVSLMSARDVVTFQWLKHGSSDIKTVLKVLLILCTMWHDMVQGTIITSYCLQGQLLISHLHFLRVKLLQHTVSGLEWMKEISEFRKLLKYFNDEYGPAVCIYTVVNMSWAMSGTAWLLKYDIQNSGINPLTCINIANVILWIWIAIAPFIQAARLTTACSMIQSVGHEVRVRPFVYQSTPGEDLDTLLLYTSSLKMCARLYRVPITGRYLCLLLTLGSVTSLTLGQCQFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3L3</accession>
    <name>A0A232F3L3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001120">
        <property type="protein sequence ID" value="OXU25070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3L3"/>
    <dbReference type="STRING" id="543379.A0A232F3L3"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="278" mass="32005" checksum="6DB4294A25817027" modified="2017-10-25" version="1">MSPSFSLELILLAFILILPFLYETSRTFRYYFKFLMYYGSVMVNAVILIPIMTFRPKNVKNLLLASSLCHHASSLLGIRWQIRGREHLEKERACIIVANHQSSLDVLGMFDLWPVMDKCTVVAKKEIFYAWPFGLAAWLCGLIFIDRMNSEKARSTINTAVEYLKENKIKLWIFPEGTRRNTGEIHSFKKGAFHVAINAQLPILPVVYSSYYFMSKSEKRLDSGRVIITTLPPISTEGLDVKDVPDLMEKTRALMTQVFHNTNKEIQLSIASNRQEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3R7</accession>
    <name>A0A232F3R7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001076">
        <property type="protein sequence ID" value="OXU25232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3R7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="112" mass="12482" checksum="14DEDEEE77C01AB6" modified="2017-10-25" version="1" fragment="single">SGFGNGNGLRGTPCPESPVSTSSPRVSRKINNIFLRDFLFGGFRGRRTRIFVTTALPEKTTLILSTLGTRHPGEPCRCYTRKPPNKKSQRNMLLIFRKTLGVDVDTVNHGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3W3</accession>
    <name>A0A232F3W3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001080">
        <property type="protein sequence ID" value="OXU25219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3W3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="127" mass="13611" checksum="A71756C3272B18B0" modified="2017-10-25" version="1">MRFSRPLTCPSRAPLAIILSSTSPAAARPASSFLQRFSCKLVRGNRSCSRTREARASCPGCPGPEDNSSNSSAERSARTHFPWSSSSSCRAVVRGNCAVYCAAQRAPGTHRLSCARSERCRCSCPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3X0</accession>
    <name>A0A232F3X0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">CDK-activating kinase assembly factor MAT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDK7/cyclin-H assembly factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7 10">Menage a trois</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">RING finger protein MAT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_012041</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with CDK7 and cyclin H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001022">
        <property type="protein sequence ID" value="OXU25451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3X0"/>
    <dbReference type="STRING" id="543379.A0A232F3X0"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16517">
        <property type="entry name" value="RING-HC_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057657">
        <property type="entry name" value="MAT1_CAK-anch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25811">
        <property type="entry name" value="CAK-anch_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003338">
        <property type="entry name" value="MAT1_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="99"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="319" mass="36559" checksum="413FAA26184F2C21" modified="2017-10-25" version="1">MEDQACPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFLKGSGSCPECQTPLRRANFRVQLYEDAMVEKEVDIRKRILRDFNKKEEDFATQREYDDYLEEVENIIYNLANNIDVIETNKKIEQYKRENRELILKNKTKLGKKESELEELLELEKMEQEERRLELEKQEQEIKKRKIREKEALIDELMFSEGDASKIVQTFASSIQSSKEEVKLAPKATGFSTGIKFGQQNSTGFVPLPKMDDGPTYQYVPITQEIEGPTPPGLKEVQVRGYISNVRKETEAEKAGGFGANIACLRALQEAMASLYHNPSKPSQEVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F421</accession>
    <name>A0A232F421_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Ornithine aminotransferase</fullName>
            <ecNumber evidence="6 11">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_012416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="6 11"/>
    <dbReference type="EMBL" id="NNAY01000993">
        <property type="protein sequence ID" value="OXU25576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F421"/>
    <dbReference type="STRING" id="543379.A0A232F421"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="431" mass="47899" checksum="470E28DDB02B7098" modified="2017-10-25" version="1">MSLSRLSSARRLLSSSKSASAALHQTSRNVSSQEVFEREHKYSAHNYHPLEVALKRAEGVFMYDCEGKRYYDFLSAYSAVNQGHCHPRIYKAMMEQAKQLTLTSRAFYADALGEFAEYITGLFEYDKWLPMNTGVEGGETACKLARRWGYDRKGIERYRGKIIFAEGNFWGRSMSAVSSSTDPSSYAGFGPFMPGFEIIPYDDLEALRKAVADPNVCAFMVEPIQGEAGVVVPKEGYLRGVRDICTKNKVLWIADEVQTGLARTGRRLAVDHEDVKPDILILGKALSGGFYPVSGVLANDEVMLTIKPGEHGSTYGGNPLGCRIALEALRVLEEEKLAQNAEKLGQILRAELNKLPKEVVTLVRGKGLLNAIVINEKIDAMEVCRQMKDEGLLAKPTHGHIIRLAPPLVITEEQVHECVDIIKKVISRQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F442</accession>
    <name>A0A232F442_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_015992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001077">
        <property type="protein sequence ID" value="OXU25223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F442"/>
    <dbReference type="OrthoDB" id="7687339at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="831" mass="98883" checksum="64E426402C6DB9F5" modified="2017-10-25" version="1">MQEAAIRLREMAESPSTEKQDSLEDSLSSEEWTIIYKKESKSKDADDEKTDSEKPDESKETMISEDAYKVEESTKTEAEHIDEGVEAGEKEIESDDVSILSDESEPEHVVFEEGRIERIEWQVERKPSVQSRAVAPTTQSDGIITANALITCSVVALIFGIIIACQIVEYRADKPISYTGNTEIEDKLRELSGIEEKLKELNDVRNALEQIQISMPEMKNLKDQLTYQKYEKNKASHLIEDYKNLEKLNLQNLLNLNTHNDRLELLGTTYQNFCSTIKRINSSSSVIENELCETPKILSDMIVFKKNLRKAFQQTQDIMSPEKRILDDAEKKLDSVSDSLLSEMTVMFSRFSLKVQERLNKFGYKLNKRLCSMSNTGRTNDKFFNILLDKDFYINNCNETSNSDAVVLDSTTDIPYKKEKNHGMKKRSYEELKKNGYKYDYKNSKDYKQIKDSREYHSEKEYNEEIYIEKSKGEVKNGNNWKNKKYENKDKHSDEKKYKHEKPNENLKNENNKKVKEEREFESFLDNKVKEHHHDRKFEYNQKDNDYDRKSENHKKERDYDNKFEQYKKDNDFNKKFEHKKEHGFDQQFEQKKKDRDFDQKVEYHKKDNFDRKYDHNKKERDYDKTFGNKRNFVVYDDDDSKFIILENDGDEFVTSNEFQPKFKKEKEFPQRPDSYKESRYTKYTGNDRKDNKKDKYQPSGDWQMQRLQYYMVPKHHVCAIITIIRPVEGKAREKLRNSDWYFVRADSRQKARIVEDSDDLEVGEEAPWSPPRPHKKRQQHDHHHRTENDNDDHSQKSQTRCPAVDNLRKRVLRTVGRSWEFLNAKLRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5G0</accession>
    <name>A0A232F5G0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CCR4-NOT transcription complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CCR4-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_016088</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000895">
        <property type="protein sequence ID" value="OXU26031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5G0"/>
    <dbReference type="STRING" id="543379.A0A232F5G0"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000001">
        <property type="entry name" value="Putative CCR4-NOT transcription complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="17">
        <location>
            <begin position="371"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU26031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="510" mass="54996" checksum="2F212BA917249D87" modified="2017-10-25" version="1">MANLNFEQPPRSIANASLATRAANSAGGLNSSTLAGHVTPTSGMFSGSSTSTSGAANSAVIGPNLSYHPGGAASGVAGAQSTSNHQSQQQQQQQQQQQQQQQQQQQQQLSPMNSRGLFGQRAFTSERRNMPTLGNTNPMGGMSGFGIPQSRNYGSQGTINNFHSAFGSGTSTGGGGDTSTPPLLDLSEFPSLTNRGQGDSSMPQPSPMPGKQPYVGMVKQPTSEASEFTMSSEDFPALPGTQSRDGPSPGGSVMSGDKGLSVGLGPDLSPDVLQANRTSNSDKSQSSKKGIQTSPDGSYDIFGIKLKGIKMTTFRKVTNIPASMVKDQFGMVGLLTFIRAAETDPNLVTLALGQDLTALGLNLNSPENLYQNFGGPWAETPCRPQDIDFHVPPEYLINATIRDKLAPVKLNRYKDDLLFYMFYTNVGDVLQLAAAAELFSREWRYHTEEKVWITQAPGLGLVEKTSTYERGTYYYFDAQNWRKVAKEFHLDYTKLEGRPHLPNTFHQNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5W9</accession>
    <name>A0A232F5W9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000934">
        <property type="protein sequence ID" value="OXU25848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5W9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="26" mass="3141" checksum="9B31E5931B981795" modified="2017-10-25" version="1">MREIKKCLCATYVHLPETRRVLCFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7M6</accession>
    <name>A0A232F7M6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000710">
        <property type="protein sequence ID" value="OXU26854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7M6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="14256" checksum="A4918071EDA4B563" modified="2017-10-25" version="1">MDYECTLLSSLEEQSTAFNWTIENRNLIANTPGKFKPKPFTLIDSSVKCSMRIMSQNKNFPGVIFIITNCLKSRKIKYATLLLRRQKENLAIASPYVLAMFSKNLKESTESVVDLTKDIDVTLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Y2</accession>
    <name>A0A232F7Y2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000691">
        <property type="protein sequence ID" value="OXU26954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Y2"/>
    <dbReference type="OrthoDB" id="7634006at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10568" checksum="7D2B26B78F8059AE" modified="2017-10-25" version="1">MSPLDDIKSTTSVESELMVSDMLEEHEHHHHSIGLGAGKRKRQDDNDGDDLGPRKLPSLASNNNDVSFVLEEHNAEDGLHDDRDDVSFGEKYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAK3</accession>
    <name>A0A232FAK3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_005192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000620">
        <property type="protein sequence ID" value="OXU27357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAK3"/>
    <dbReference type="STRING" id="543379.A0A232FAK3"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="81"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="202" mass="22555" checksum="076D9A5E238F3DDF" modified="2017-10-25" version="1">MPSYKLTYFPVKALGEPIRFLFSYGGVDFVDDRFDQADWPKIKPTTPFGQVPILEVDGKKVCQSTAICRYLAKQFGLAGKDDWEALEIDAAVDTIHDLRAKIAAHHYENNATAKTEKLAAAKELVPFYVQRLDEQVKRNGGYLVGGKLSWADIILVGLLDYLNFMSGHNIIENAVNLKALEAKVLAQPGIKAWVAKRPKTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB20</accession>
    <name>A0A232FB20_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000536">
        <property type="protein sequence ID" value="OXU27812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB20"/>
    <dbReference type="STRING" id="543379.A0A232FB20"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF60">
        <property type="entry name" value="3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="493"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="963" mass="107297" checksum="691F889575981263" modified="2017-10-25" version="1">MDDKEFREFGKAAIDYIADYKENVRDRDVLPSIKPGYLCELLPKEAPEKPETWREVLDDVEKHIMPGVTHWNSPHFHAYYPTANSYPAIVGEIISAGIGCVGFSWIASPACTELEMITMDWLGKLLGLPEEFLNSSPGPGGGVLQGSASEATLVGLLAARETTVNRLKKEHPDWDEAIIRSKLIAYTSDQSNSSVEKSGRLGAMTMKLLPTDEKCSLRGATLLETIKKDIEDGFIPCYVVATLGTTPTCAFDNLDELGPICNKYNIWLHIDAAYAGAAFVCPEYRYLMSGVQYADSFNFNPHKWLLVNFDCSALWVKDSRFFTESFNVERIYLANNKEGQTHDYRHWQIPLGRRFRALKVWFVLRLYGVEGLQKHIRHTIELAQRFEKLVNDDNRFEIPIERQMGLICFRLKGEDKLTMQLLDRLMSRRKIYVIPGAYREKWFASAVTPGDGGSGKEVPPCTKIAKFDTCQLDPCMLDPCNPEPTVVIIGAGMAGLSAAHRLAQCGLKNFTILEATDRPGGRIHSCWLGDVVAEMGATWIEGGCVANPVFTLAAQEGLLKPPLFRPDPSKGLFCTSEGRAIDLPVSITAYHTFRQIEQQAAALFSLGCGRTHGNLLNFMGIRIQQELHNFPEEQRYDAARVMYGLTNCVRCRCGDDLSLVSADQFGSYVEIPGGNVRVPLGYVGMLAPLLRDLPSCSLKYCKPVSCVRWGAVNESCPRALVKCCDGDEFYADYVVVTVSLGVLKHQHEKLFCPALPAEKVEAISRLGYGCVNKIFLEYERPFWVWSEGGIRFAWSADELADRCDWVKGISMVEELAGSQHVLCAWVCGREAADMELCSDEEVVDSMTRLLRQFTGDPTLPYPTNLLRSKWCMDQYFAGSYSYMAMDSTVGHQCDLASPLPGSCEPVAPILLFAGEATIPGHYSTVHGARLSGIREADRIIQLTKRFNGPPKKFPEPSPPCPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBL5</accession>
    <name>A0A232FBL5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. PAR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000528">
        <property type="protein sequence ID" value="OXU27860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBL5"/>
    <dbReference type="STRING" id="543379.A0A232FBL5"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000007">
        <property type="entry name" value="hepatic leukemia factor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="178" mass="19832" checksum="68AE37DBD0309272" modified="2017-10-25" version="1">MQASQLHKLGGANASNNAAGPGGNGDVQATGHQGPAGLHLEPVTKRERSPSPSDCCSPDTLNPPSPADSTLSMASSGRDFDPRTRAFSDEELKPQPMIKKSRKQFVPDDLKDDKYWARRRKNNMAAKRSRDARRMKENQIALRAGFLEKENMGLRQELDRLKNENMLLRDKLSKYTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBW2</accession>
    <name>A0A232FBW2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_006960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000470">
        <property type="protein sequence ID" value="OXU28145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBW2"/>
    <dbReference type="STRING" id="543379.A0A232FBW2"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="534" mass="60212" checksum="2895FA63AAD8A461" modified="2017-10-25" version="1">MDETSETDQKNYISCLTWVRRGVAASVPDKIELTPQELQNIIQNTQSELNQIKEEDDSEDEEAAGTNESKNTTTDEEMKDGSVKANDEFDFDKYDDEADDIYANIDGIAVINEGKDPLVTVGDSEDEDSEKEDDIIKANDNLVLVGHIMDEASILEVYVYNEAEGSFYCHHHDYLSYIPLCFEWLNFDPSEEKPGNLCAIGNDTPVIEVWDLDVVGGIGPVFKLGKKLNKKKNIKRVGHRDAVLDIAWNTSHNHVLASGSADKTVLLWDLENGTPSTKLSSFEGIIQSIKWHQTEAHMLLTGSMDKKVRLFDCKTEVAKTWKASGEVEKVVWNQFDSNLFFVSTDNGYIECVDIRHDKPLWQKQVQEEEIAGLSMSVSCPGLLVSTNKDGTIKVWDVKNYLEPQLVLEKQTNLGHIICLESSCDSPFIFAAGGDNKANNLNVYDLSTIPEVSERFQNRELIHPTHVVEFSKTNKLNTVNEEVMEVADDIGSIALESKRPNHIAKKKKKPRHHCIGRRILYFLSLKSKDALQHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBW6</accession>
    <name>A0A232FBW6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000503">
        <property type="protein sequence ID" value="OXU27953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FBW6"/>
    <dbReference type="OrthoDB" id="7699017at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1117" mass="127761" checksum="6A5673A1B22296EE" modified="2017-10-25" version="1">MQDCDKKYNVLSSFTSHLTKQHRNSYKKVQDSEICEQSEIEESQTTSDSVETQSLECVVDNENQSERFEVDGDAQSESPVENPSLEESSDLYLHNLAQFYLKLETQLLLSASTVKTIVTEITNMQRESQNIVMTSLGRKLISEGISADKVDIIVKEIINEDPFLKCNIELGNAFEVVNPIGAAKKKHKILEVYMSIGNLPENLRSHVNTIKLVTLCKEIDFDYQKVYGKIVEDLKIIXKVHIKKNDQITCPMQDCGKKYKVLSSFTSHLTKQHRNNYKKVQDSEICEQSEIEESQTTSDSVETQSLECVVDNENQSERFEVDGDAQSESPVENPSLEESSDLYLHNLAQFYLKLETQLLLPASTVKTIVTEITSMQRESQNIVMTSLARKLISEGISADKVDIIVKEIINEDPFLKCNIEIGSNYKRKQFYKENFDFIQPESLSEIEESQTTSDSVETQSLECVVDNENQSERFEVDGDAQSESPVENPSLEESSDLYLHNLAQFYLKLETQHLLPASTVKTIVTEITSMQRESQNIVMTPLARKLISEGISADKVDIIVKEIINEDPFLKCNIELEKTQLLLPASTVKTIVTEITSMQRESQNIVMTSLARKLISEGISADKVDIIVKEIINEDPFLKCNIEIGSNYKRKQFYKENFDFIQPESLVIDKENQTYFSYVPIIETLKYTFHDKSIQHEILKKPEPRDKDILFDFMDGTVYKCNTFFNDNPDALKIILYQDAFEVVNPIGAAKKKHKILAVYMXIGNLPENLRSHVNTIKLVELCKEIDFDYQKVYGKIVEDLKIIETTGIEVGEKLLKESLVHICGDNLGSHSLGGFTENFSRAKYICRFCNIERTELEMVHVASYANALEQKGNSNDFEGIKFDSVFNQLVQQKWFTLQQLNSRIDKFPYSIEVRQNKPCTLSLNSEKITVGAVQIWNFLYILPLLIEHKIKDAEDDVWQLLIILTEIVKSLSEKHELHQSLVRLGADIRLEVETFDLNDFQIDVYSADIINAIRKADLPSDIQESSKIVIKGTAYKKGNILALNQYEYQNNVIFETEFIPYLRAYXQFSINSNIIMCVPLDFLHALDMICLKELSLMICDCLLTILYNKNGLLYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC78</accession>
    <name>A0A232FC78_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000433">
        <property type="protein sequence ID" value="OXU28424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FC78"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556727" description="Vitellogenin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="703"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1975" mass="225929" checksum="C668C9355A66F0FD" modified="2017-10-25" version="1">MYTMRATLLCLSLFFFYGQDKVKSSEYHLADAIEDLNFFIPGSKVILTTAIKIWTVYGEVRQLIDPNSTSLIEEHLQEISNSLSEITEQLDFMSDKLDNISDDIRDVKNLITDKVINDLPKELRLDNELINIYGDINKVNGMFEKFLHYNNVSKHYENSTLINFANRVVDHSLGELYSVLNQIHHSLVDRYTGINMLDIMSNSKLASSMMCKRRESAQHFINNLYNNIMLVETKAFIMTQFAYSVKNAFSNKTTSYITELDDATTGSYIRTSASIAEIKKAMYLAPRDVWSCDPPEHKEDETFTKLAPIFQTYIMKENDSGISSYLNKYTNKCSDTCAERTDTYDLCRSQYCQQHGRKCSGRVHDCKSSSAELKICAADKNSTKRYDSITLTGKQAEILGSKVPCARNTAINLREKIHYFYKCEYCFCICDDSNTEIDQMLLLTVVTGIRFAKKNNIIHIQIEQGQLLKNGNINESTAHWKAVDNFTIYDKMVLIDRDYHNITWSQRSVDLDTLDSPLNNVITGLRFQNVDGHLKLEIQVTPIDFYRGELKIDESTWISNSKSVHGRTELNVENLDLGTSTYVNLPDSSSNKFFKFTTSSMETDVGQSVVPFIDLQDITSSPPVLLSGAAKMNTARGALLFLFLFFICGQQQVKSVEYHLADAIDDLNFFIPGSKAILTTAIKIWTVYGEVKQLIDPNSTALIEQHLQNITEALEEISAQLDQISDKLDNISDDVHEIHDLITDEVLNNLPKELNLDTKLSQIYAKIHDINQLFTKFLRYNNNIKSYENDTLLNFANRVTDQSLKEMPSVLSQIHHLLTERHSNANMLTIMANKRLAKSNMCKRHESAQQFINNLYNNVMIAETKALLMTQFAYSLKNAFNLNSTSFVTELDDTNKEFCNRTSNSIAAIKDAMLAAPRDYWSCDPDDHVEGLTYAKLDPVFQAYVTSEKDAGISKYFKAFTNKCADTCSDRDDFHDICRSSYCFKHNQKRCYGKLHNCKSSGKNLRMCLSDKNSTRRFEFIELTGKKTEFLGSKKSCGSNTQVKVSQTTLFIETCEYCFCICDDTNNEMDRYFSLRNVNSDVDKNMVVTGVRFAKENHIFHIQIQQGKLVENGNIKASTVKWKPVDKFTIHDESVVLNRDYHNITWANRSVYLDTFDSPLHHVLTGLRFQLQNGDLKLEIQVTPFNFYTAELKTNESTWMSNSIGAYGRGELDLENLDLGTNGHLNLLDSSENQYIKFTTSSMKTDVGQTVVPFMDLQDVTSSPPVPLSGAGLVHRGDKASAGFLSFKVLTYNYAPYLETDCICFLILLIYGHHQVSSMKSTYKLEDAIEDLNVFIPGSKLVLTTAIKFWSVYNEVREMINPNMTAIDGHLQEMNSALIDISDSISEMSGKLNTVSDDVKEMKDLISNKLVDVLPKYQRLQNIIEKIKRKIHKINGIFEDAFTIKNTGYEKYEDKTLSDMVNSITQPGASNLNTLLHQIYELIMDNDSKDKFLDKMANKKIAFSMMCDKRESAHHEIKRLYQMVTIAEIKNLLLVQFAYATQNLLNKKPGGNVNELKNVVDKFSRRTSRMTAAFKNAMIKAPRDFWYCDPDEHAEGLYQTTHYFIRDDYYTQLLTLMVVLLGSTYAKLSPIFQAYIMNEKDSGLTLHDKKRNKCKGSCKDHNETNDLCRSKHCRNYEKKCSGVVRDCTSSAEELNICYANTESSRRYEFVEALSSGNRKFYGKPKSCSGNNTLQVKNRFNKLFYECEYCVCTCEDINTKMDRYFRVRFAKKNNIFHIQIQQGKLLENGNIDKSSVDWKPVDYFTVSDKHVVDHRDYYKISWNQRTVYLDTLDAPLNNVLTGLRFQIDGSNLKFEIQMTPFNFSSGELKKHESRWISNPPSDRTEIYLENRDLGTSTNQNSYHFEEGNNQLFKFTRSSFESDAGQNVVPFIDLQEIESTPFVPLSGAGLILRNTKESAGFLSFKLLTYSYAPYMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCF8</accession>
    <name>A0A232FCF8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000421">
        <property type="protein sequence ID" value="OXU28516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7674144at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="12551" checksum="6CBF4B0C93445CA7" modified="2017-10-25" version="1" fragment="single">MGSDEVELARVRLSDILAKARKLELPAXXXXXXXLLASRPARKLLARTSGALGRCALRLGMLVLVLAGIYVYARWPTQEVETVRTVLRRTDCINGNIFKLSCGTPIFIMTSSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCX6</accession>
    <name>A0A232FCX6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_008307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000442">
        <property type="protein sequence ID" value="OXU28350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCX6"/>
    <dbReference type="STRING" id="543379.A0A232FCX6"/>
    <dbReference type="OrthoDB" id="10070184at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF20">
        <property type="entry name" value="H15 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="218" mass="22275" checksum="3985221D7D3DAD33" modified="2017-10-25" version="1">MSDAVAETAPAAPAVASPKKAPAAKKTGAAKKPPKPRTHPPAAEMVLAAITALKDKKGSSLQAIKKYIAATYKCDVDKQSTFIRKYLKSAVEKKVIVQTKGSGASGSFKLAGKVEGEKKVVKKPAAAKKPTAKKPASENKAATKKPAAKKPAGEKKAVAAKKPKAAEKPKAAKTAKVAKSPAKAKKSGKAPAAVKPKAPKPKKVAAPKAAKPKAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDB6</accession>
    <name>A0A232FDB6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000430">
        <property type="protein sequence ID" value="OXU28448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDB6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="12847" checksum="54E26025B2D096E4" modified="2017-10-25" version="1">MPGWSTEEILLSNDHFYKLRMARYVEFTWHRLRKLGSKPRKMTPANLVQYVFFMRMNRKMPIRPYEIKYRVEQHFDNFTIEELTIIALAFSKYEALIRKLEGNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDH4</accession>
    <name>A0A232FDH4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000437">
        <property type="protein sequence ID" value="OXU28397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDH4"/>
    <dbReference type="STRING" id="543379.A0A232FDH4"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="443" mass="51085" checksum="620ED0E5A579B088" modified="2017-10-25" version="1">MQEDSCFELHSEPLSTNNILSGIRLCLKGTPDVVHFHMLDISPDLEFHDLRVTLIGYDHKILHKTGTTTKESHVVSVSLQLSSVLKVIAWEDVMTIHCEFDSPSNDYETKKEKPFIYGKRHTSKALDQFESLLDNSEYSDVKFIVGKKTLYAHKIILAARSSVFSAMFRHCMREKEQTIINIEEISYEVLKEVLRYIYAGKVNQNGSIIAKELIVAADKYNIVELKDECGKLLCNSLTSENAIECLNFAYLHNIDNLRESAIGFIVQNGKDMLNKPGFDSLGDLNKELMIFEIEKTMVEELGENNYKFQALDRFETLPDNQEFADIKFVVNDKTIYANKLIQSQEAPFFLIFLFKKKDERCQRKYQIEKFAKMCKNMSIDNVIEYHHHSADLHNVQQLRKKAIDIIILNGKMIAKRPDFNSLLKLHEDLVLEIVRSELSQEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDM5</accession>
    <name>A0A232FDM5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000365">
        <property type="protein sequence ID" value="OXU28861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDM5"/>
    <dbReference type="STRING" id="543379.A0A232FDM5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="205"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41779" checksum="CEC9968E756D93DD" modified="2017-10-25" version="1">MPSKEQGEISIVHAKYKWVIDNFCTGCLKPGECLVSPTFATYYGAKKNDWYVKLYPKGTTDTIKSWISVFLCSSTTTDFKATATFKILNSQNEEFVSHTTDEDIFIEEMSRGFQQFVTIQHIMDRNLGLLTDGRVTIVCELVVNANKENDIVSVMEKMIVMGKCLRLQNELKNLKDTVEDKDKTSSLRFKELEELEQLIGETNYSDVELCVEGKTIRAHKCILALKSPVFAAMFQTEMKEKCENKVQIQDIEYSVFTEMLRYVYSCQVTDIKTMAVELLAAADRYSIDGLKAACERTICSSLSVDNAAKSLQLAERYRLDELRRMAIHFIVRNSKKIVDKPDFQLIGLDTTREILRAVVKYTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE53</accession>
    <name>A0A232FE53_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000384">
        <property type="protein sequence ID" value="OXU28758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE53"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11134" checksum="49F123ABF314B955" modified="2017-10-25" version="1">MASALTDRGSSPVARLEYSRDAPSSRPLLLSLVPRCGVCMLRTSDRNHQTPLLQPCPLFFRVLLDAFASSFARQGFEGFCTTTTFWLHSANVIAASLFLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEJ1</accession>
    <name>A0A232FEJ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000327">
        <property type="protein sequence ID" value="OXU29204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEJ1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8004" checksum="38A7D3EC504C37CA" modified="2017-10-25" version="1">MVAQKKQVLVQIIVKFWQRGRILHTVPAIIGSAIIALFGTPATDIKAVVEASVNGAIYSLVMGLRNDSSGTRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEL4</accession>
    <name>A0A232FEL4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000350">
        <property type="protein sequence ID" value="OXU28993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEL4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12068" checksum="05900958035CCE10" modified="2017-10-25" version="1">MARQRGRKGCYLYGASSLSGFSKLKFSWGLSVVALRTMYPFQLYKDYNSNNIHYDDLRGSNIIGLIIRLVNISAPILWLENTLKIIFAYARSARQRFIAAAAATADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF28</accession>
    <name>A0A232FF28_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Dystroglycan 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Dystroglycan</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Dystrophin-associated glycoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">TSAR_001829</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">Alberta</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000345">
        <property type="protein sequence ID" value="OXU29039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FF28"/>
    <dbReference type="OrthoDB" id="5990676at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016011">
        <property type="term" value="C:dystroglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11303">
        <property type="entry name" value="Dystroglycan_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1040">
        <property type="entry name" value="Dystroglycan, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027468">
        <property type="entry name" value="Alpha-dystroglycan_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041631">
        <property type="entry name" value="Alpha_DG1_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008465">
        <property type="entry name" value="DAG1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030398">
        <property type="entry name" value="SEA_DG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559:SF21">
        <property type="entry name" value="DYSTROGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559">
        <property type="entry name" value="DYSTROGLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18424">
        <property type="entry name" value="a_DG1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05454">
        <property type="entry name" value="DAG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111006">
        <property type="entry name" value="Dystroglycan, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51699">
        <property type="entry name" value="SEA_DG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="26" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 27" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013302855" description="Dystroglycan 1" evidence="27">
        <location>
            <begin position="20"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1226"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="28">
        <location>
            <begin position="851"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="28">
        <location>
            <begin position="1080"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="306"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="408"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="655"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1258"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="438"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="662"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1261"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="1350"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OXU29039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151420" checksum="3ADAAD626BEA234B" modified="2017-10-25" version="1">MKKLRVAALLLLLLPLSLSLSQQEDDLVFDDVGDEASTLEPERSKEQQQQQQQQQQHTPANAKPKKSQRVEKLLGMPDAIANVGHVFKLHVPKQAFAGNIDYYEARGSNGKGLPHWLRWDEPASALYGVPARKDVGRHRVSVKAFGKHGDVAQDWFIIHVVPEKREHYGHKDGKKRCTEDQDRTMLTILIDARYENLKPSAKVRALENLAGFFGLHPSSISIQPEVKESSSSASSVLSGPGNVGRRREKHSTLVQWQVGCDGHFWPHQIDTIKQIPEQARDGTLSEVMELPVYQWRVRTDSTDFARNRRDAAAGSGDGLLPDEEDDDEEDDDQYDDYEDEYDSNSEGITETPQEPKQKPVFVPSGTGDNDGHPHRHRHGYGSVANIGPSINTEDEEDYIWRNSDVNNSIFNATPSTTSTTTTTTPSTTTETEPPPTTPTTTSTTSTTEAPTTSTSTTTTTESTTTSTTTSTTTEHVPEPSSSTTESTTTTSTTTTQATPSTVDILTNETTTTTTSPYTNLTQVATGSSNTQTNVTTDSLTVDNEDPLVTERDIDNETETDEMTTLQPSLFNGSESTTAGSSGAPASNTSIVEVSVSTEPNATSIFTVNATTEEYPEASVPVKESSSPSSTTSFPTNSWNDTDTDKIFEESDPYDTMHVPVYSSTPSTTTSTTTEEPTTTTPEPSLTTTITTTTTTEAPTTPSTTPTTTSTTTTTTTPAPTTSTTQSTTTTSTTTERIEYGMRNNPPRVQRRLKKIPITQGKPLSYMIPEETFRDDEDGNTRQLRLRIYEKDAPLKSSYWLQFNEETQEIYGLPLEDQYGTYPFEVVAMDSQGLTTSATLDISVQQHKQIRAVNHEFHVYLKIEKRSEFPTNVDWELKVMRSLAELYGDEDLSYITVRSIDIDGDQAIYTWTNDSLARSNICPQDEINRLYSILVADENTEEPSEGLTHVLGPEIRPKRVVYQGLQQCQQIKETQVNKYPVPRNQIDQLNATVGQLFVYKVPKDTFFDEEDGDTGSMKATLLTANRSEIPASDWLQFDSSNQEFYGVPLQQDIGRKTYQLVVKDREGLEATDSLVAEVHPSPNMRHVVEISMILNMGYDTFAKSAQKKREFIQKLQRLYGDKNTSAISLLHINGNGDTTTVTWSNLTLPTNECPSQEIDQLRGVLGKDNNLSDELIREFNSENQPEFAVIQLTVKSTGACREAGMIPPDQLPVDESTSVGASHDDHFFTIILPTIIIAALILLAAIIACILYKRKRSGKMSVSEKDDERQSFRSKGIPVIFQDELDEKPDPGNKSPIILKEEKPPLPPPEYQRAEDGADIPMLSKENSEEPYQPPPPFATNRDNNRQNRPKPTPTYRKPPPYVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFP7</accession>
    <name>A0A232FFP7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Anamorsin homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Fe-S cluster assembly protein DRE2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_007504</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000319">
        <property type="protein sequence ID" value="OXU29259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFP7"/>
    <dbReference type="STRING" id="543379.A0A232FFP7"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049011">
        <property type="entry name" value="Anamorsin_N_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20922">
        <property type="entry name" value="Anamorsin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin N-terminal" evidence="12">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU29259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="291" mass="31709" checksum="E41BEB9C2C7AADB8" modified="2017-10-25" version="1">MIAAEFTPEVSIIVINSLTTNNMANFVKEGNKVVVLLAPNENDIAAKNFVDEINKVTGSAGETLMVNSTNLQNQKYDSSSVDVVLSGFTTPFNHSDDLLKELLRVLKPKGVFVAHEPLDKTNETDFSSQKAKVKLTGFLLQDKEPRAITSVDGKNVCEIVAEKPYYEIGSSIKLSFSQPKPKVWKLEDDGEEEDLINEDDLLDESDIVKPQATSLKVCSTTGKRKACKDCSCGLAEELRGEALAKEQPKSSCGSCYLGDAFRCASCPYLGMPAFKPGEKIVLPDTQLTADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFW5</accession>
    <name>A0A232FFW5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neuroligin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000326">
        <property type="protein sequence ID" value="OXU29207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFW5"/>
    <dbReference type="STRING" id="543379.A0A232FFW5"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28544" checksum="F4AB8BA90780D095" modified="2017-10-25" version="1">MPISREKSRFRSLTWDQYDPVHQKYLEIGMKPKMKNHYRAHQLSVWLRLVPELHRAGMEDVEPRHNLFRGYADPNLYDGFVRPDPLSRIVSPSNDLDSQRRGAGSAAKNATTEPPTTTDYSLTTCVSLIQSTNIQNIHNASTDTLASLDAAGYATYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKSLQQQQMMNQQCGPRGFNDLKQPPPPPPPHTHFPGGGQVIVDVENEMIRRYSTWFHLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGC9</accession>
    <name>A0A232FGC9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000238">
        <property type="protein sequence ID" value="OXU29804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGC9"/>
    <dbReference type="STRING" id="543379.A0A232FGC9"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="706" mass="79151" checksum="FA43AC5FC5CEAF37" modified="2017-10-25" version="1">MSREDKEFARTTMTWWTDLKQLIRNGDSDGIKSMLSQVSVADIRDDHDSNLLHYFTNTDNETIARQLIEAGCDINLKNRYGETPLMTAVESNNLKIAKLLLDAGAIHLNTNFIQEFGPLHMAVWYGFKAMVQILLDAGADANVIDDEYSSPLHLAANVEPIPAQPCLVPGDNKCNYDIAKMLVDAGADVDAVDYQAISPLHWAVMRGNYDVAGLLLDKGANADVMDDNFVTPLHWSVRDQNIEFVKRLIKAGANVDMVDCHGMTCLHYAVKARFDGMVWLLLSAGATPNCTDGQGYSPLHWAVREESLELVQILLEAGADVNIQDDQATEGLSALQVAAELGLKDIILLLLSHGADVKAKCNRGCSVLYYAAMCKRINFHVDDELYVELLRLLLDHGAEIGDSSCSVKTSFDSALLYWNEQAVRLFIERGVDLRKCILENSKSSSLYDAALNNGKGVLKLLIDSGHLNIEQKYGSGLTALHLASFWNKFNCVKFLLKRGANINNNNVFGETPLYSAIQNGHAESVRLLLTYDADVNVKTTRNQTILSAALKTSRQDIVLYVVRHIAKVEAQQLRVEQENLRLIASFEDLHDFYEKCRTELALMEGSYIHGTITFFDILTARDIGKYARNEHVVRTFDTVDLSEYFPIYQDLLIERFDKEMKRQGLMKQAMAGLSRILRCDADTFHVLFYNVFHYLGTKDLRNLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGE7</accession>
    <name>A0A232FGE7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_015985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000241">
        <property type="protein sequence ID" value="OXU29772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGE7"/>
    <dbReference type="OrthoDB" id="8959630at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="8">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU29772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="141" mass="15207" checksum="3C489050A5DEF2A9" modified="2017-10-25" version="1">MPRGLPGRRGLQALVLVLATAYATVLLYQAVAPRQWVDDQAVDETSGDPSLDVPIPPRFERILVSASAPGIVEDVAAVTPSVATATMAPFSTDLEDVFISVKTTRHYHHSRLPAIIGTWFQFAKEQVCTGVKSRAIGLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGG2</accession>
    <name>A0A232FGG2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000229">
        <property type="protein sequence ID" value="OXU29851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGG2"/>
    <dbReference type="STRING" id="543379.A0A232FGG2"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="253"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="596" mass="67317" checksum="01D2748AB471EEBA" modified="2017-10-25" version="1">MSDEPLTKKPKLSGEEFAQLKEKLKERKKRLTAIPRIRLLAVGESASVCDTISEGDRIPIFLGDVQRLLVYSMLGHHAPYSPERWIKLDKYNKVTHTVVFIVEGLSINHYVTNESAFKHLTSELEHKLELITPSSYGGSVVDELAAVPLTGTQKAKLLKKFGSMEEAMKSSGDIIKLFRTIFPMQPVVKKDTNADKNIQLPPTDKFSRTELILSPWQLVEENYPIPLKGGLAKKYDDYVLTKDEYVEVNSMSPMYGLDCEMCRTTSGILELTRISIVDEKLNIVYDTLVMPDNKIVDYLTRFSGITEKMLENVNVKLADVQKFLRAFLPPDAILVGQSLNSDLHALRMMHPYVIDTSVIFNLTGDRFRKTKLKVLSEAFLNERIQTGKAGHCSTEDSQASMKLVQLKLSHSIHFGDSVLIDQSYIDSYETKIKEDKKSVRLKQDGTCTLSSLIFKHVTKVDQKTAAIFGCNEVMNDYSKILKNSSLNIMEDKHFDKGDNVRLVIADSNKEAITRCSEVAMEHALNFCHIKLNEEELSEEKLPKTLNSVDKWVKKLWQHTALHGLVCVIFSGEKNSSNGACFLNIKKNIEELNGDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGY4</accession>
    <name>A0A232FGY4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WASP family protein member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000233">
        <property type="protein sequence ID" value="OXU29823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FGY4"/>
    <dbReference type="OrthoDB" id="8965057at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1816"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1745"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1895" mass="208822" checksum="5B5D0F14640E1832" modified="2017-10-25" version="1" fragment="single">ESDICTFAQRTVHFHVGNEPERCLFTLDTRPKALRQLYDAAAAVAVRSLDSLRRDRDATTSSLEMFMCTPILGKRRQREQSLDIESRVPRAIEDLRRWTSAEALGDVTVAPDCMSRILADNAMDDSQPVDHKLPSPEEQVQAVALKFPAEIVAVDVSGKGFHRMSMRRKSMHTGQESQDTVKRRSRPRRPRGKRRNTIAGTDQKEIRQAVGGEATADEPEDAQASGVSKRTPRSASTDLLGSGGSKKDSPVEKKSHFNTLKAWGRSRLKLISPKSNQQNHAHSDVNASTISLSSIAMASRQQVVDDDIHVVEDVVTYETLTIGRRSRREVLTHERKPSSSSSTASSIQKPLAQQQINGPTTSLSKDEEPEKISGSLATQQSRRDSVKLRESAAERRERRKASSRADEPPHSSSGNWSASSESGRASIGSETTTTTHPPRSTTTASIGTSSTSLSHARRFKGRDTSASSSVTSEGTLTPDIIQDISAVPFSDDGETSSVYSCDTEGYYTSFHVDSGLKTLREEEPPMPQSPLTKSNEVQSDPTSPMMENEYELFGRGSTSTTTSSAGTVCTTLMAPPPPERKSSLTVVAMVHGQKQNGGESPDSGHNTSSSPVESASSPACTGRSCSEFEYSESSDLEGCERIERIRSKTAINTSRIPSMCVITPPGSDDEHNHHHHRHHHKEHHHSKDQKQKKDRNASPGSVLMSATVGTSKMEVINGQDKNLYATVQTVMAPTSSNNNVEKTPTGQNSNNNNNINNNNNNQKISPLSGVLGKLRGVLPGRKHQQKPITAQEAGQQQHNHNNNLQPDSGDYVTIADVRNNNDKRRQDNGGLTTVRPSAGVTYANADLFRRDAEYVSLSELPKKPDSSLERRRQGARVTLDSEGKVVYSSDSLKRRKGAHTTFIPVVGPTNATTTQRQTRQGAYVNVQGAPDEGKTATRNTTPRKQSTKASRAVRTVPDSRFGDAENRPPDGVKRGKHPMTLRFRHNKTLSVDRKVLKPSARQMALLPKGLIPNGNTPKLIRRLPMPDPIVEPVDKENSESAANATVVDDSEAKITETPRIERKLKRSESYRMANSPIMFIKKFSSGGCSSASSDKAHSQKIFRTASEELREDLLKERINYPETVASPEPGTDVEVEVTVTLDDSGDSSSVIGSAKTLPPHSPRPRTIDLEPARVLKYSGTDTEICKKIAKSVASIMLARHLLFLATRRPNKALLAIQPSEPVSTSACSNQQPQQHKHPQQHPQQPPPYVGPPQVHKLHEDYPYQVVHQTHQLQSQLRQNLPNANNQHQAYHHHHHHHHQQHPMYAQHIVDPYQQLIYEKAQNQVYSNYAENQKMYAQQMHNPVQGYNKVSQQQQFYTLPNRRPQREVILEPPRSITPDITRGLARHGALSAAHMLARQGQKAGSAEKLIAHHHGQGGYNCQADLNRKNLEQFEARCKPSAQQHQTPVDVKNRFASPLGLSALGYRFFASTIQDGLKSVPISPIGPEHTNGFKSSTPTSGVGRVAPTVAERLALQSQRCVSPNPALVQQQQQQRSDSPASLVLSPIRSTMSNEELFAAIHKSKRRLNIKDDPESLSPAGSVTSLSKGQQVVGTRHSWSPESQKVPEIPKTVLSPSATSRMDFKRLLLQQAVKAGPTRISAAEQLKLSRQQCQDAHQQQQPSSPKPSNQQIPLTKVLSPRSAWRFQTPRTDVLSSTIIEDAAAEEKAMKPSPETPSPVSTFPPPSSRRQLDLGTSSTETRDIEELKNSINDSKSQQQRSLEKREKELENRLQLEADPVKAIEHRRVSNQLARAQFLATPPSSGSTVPHKDLFSRRFRARSESPQQHNSGNNSATRDLSPPNTTTNTDSGEGALVARSPSAPALETALRSLMDESCVRASNRFIEVQNKGTDEDFLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHG8</accession>
    <name>A0A232FHG8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000184">
        <property type="protein sequence ID" value="OXU30206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHG8"/>
    <dbReference type="STRING" id="543379.A0A232FHG8"/>
    <dbReference type="OrthoDB" id="7536850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32474" checksum="19289125365E8263" modified="2017-10-25" version="1">MAQKNQYETKRDLRVRTWNVRSLYRAGAFKELIKKDDRYDLDLVAIQESRWLDGGVLASGNFTYLYGAGSGGSLGTGFLVAKASYIRLKVTNPSMIGSRTSSSKVNGIKICMYCVHCPTEVKEEEAKDLYYETLEQGRKACTKPHKASNDNGIRVINFAAAKDIIIKTTCFKHKDIHKARWTSPDGATQNQIDHFLIKKRRLINVLDVSAYRGADSDSDHFLVVAKLRAVLVANQSSKRTNKVESFDIEKLQDRTERIRYQIEINNRFQALEEANTSPEGNDEPNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHR2</accession>
    <name>A0A232FHR2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000195">
        <property type="protein sequence ID" value="OXU30093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHR2"/>
    <dbReference type="STRING" id="543379.A0A232FHR2"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53467" checksum="A7C96CDD4D107307" modified="2017-10-25" version="1">MILWDEDSTDYLVHATATSKHFYQGLGLAVLSSGFIGASFIIKKKALIRLQRYGRLRAGAGGFGYLRELVWWSGLLSMGIGEAANFAAYAFAPATLVTPLGALSVLVSAMLASTYLNEHLNLLGKLGCLLCILGSTMLVLHSPREEQIETMEDLSFKMQEPTFVTYTIFVIIGCLAIVFYFGPLYGKQNILVYILLCSSIGSLTVMSCKGLGLAIKETMNGKSEMGNWLTWALLFVLVLCIMVQMNYLNKSLDLFNTSIVTPIYYVFFTTFVIIASAILFREWEYMSIEDVIGCVCGFLTVIIAIFLLNAFKDLDVSYTDIRLIFRPKREIIIHHNSRWNNSADDEQMRYDMEHNYGTFDELKTEFKDPIDQCNSLNPLVLPEYGLHILINFLFLISGQWLSLFLNIPLIAYHINRYRTRPVMTGPGLYDPTSIMNMNDLNKCQREGWVKLAFYLMSFFYYLYGMISSLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHT0</accession>
    <name>A0A232FHT0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000173">
        <property type="protein sequence ID" value="OXU30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHT0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="189" mass="21095" checksum="42868B57AB4413B6" modified="2017-10-25" version="1">MKRDEGVTILLSLTVFLNLVAESMPTTSDAVPLIDTTRLKEQTHTWWATTVSGVTILLSLTVFLNLVAETLPQVSDAIPLLGVTILLSQTVFSLLVAHVLTRTSEAVPLIGTDDCVQYSNCLFLSIELELDGPQSRHYRSRKKRPPPSYTGSAAANSKMNLKQCFYYCHYYFFPSHPHNDIGTIRPRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHY2</accession>
    <name>A0A232FHY2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000218">
        <property type="protein sequence ID" value="OXU29937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHY2"/>
    <dbReference type="STRING" id="543379.A0A232FHY2"/>
    <dbReference type="OrthoDB" id="7697906at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="460" mass="53126" checksum="F27ECD7CA9BC3556" modified="2017-10-25" version="1">MSTKSKRPRLLYSREALEEAIAHVKAGMPVKTASDKYQIPRTTLHDKITARYADKRPGPETILTTAEENELVQWIDNSSKQGLMVGKQQLVNSVALLVKTLNRENPFSNGRPGRHWYKNFLRRHKDIVSRINENSEFVKTSADTADIRNWFHELSSYLEQKRLLDIPASRIYAAEMCVLFNKNANDTEKIYVQMAGSADGYLVPPMLLFDNNPENFYEYVIQRFHPWLVERKVDFPVVLFVDGKAPYLTLSLSNFCLRNKIQLIGLLPNLSHILQPLNKELFPSIKEAWKNILEFHLQKEATNSLKEYVAPLLKSVLNNLPIDQLLINGFLKSGLHPLTEDALNYDKVSKKIPPKSEIPEFDPYNLNEIFQIEEGEQHVEKCMNVLNHLEQWLSSTKLEIFNEAFDHEKWTGRIEDKSLFYYWRKVKTEVAYLNFEPAKSDTSCETVIVEAGVHSPTNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI66</accession>
    <name>A0A232FI66_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000166">
        <property type="protein sequence ID" value="OXU30372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI66"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15268" checksum="288F4861AEBB593C" modified="2017-10-25" version="1" fragment="single">VPDVLLLLRIGPQTIVHFRLESTKPELLVHYVAQTYELSTRSAECHSHAHLADGQLHRCQRTLHHPGTGDHRHGLSEWPGTTNMRSKFSERPLEDPETKQSQSNDGKGHCGGRDHHVPFAAHASGDATTTITIIIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKC7</accession>
    <name>A0A232FKC7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000088">
        <property type="protein sequence ID" value="OXU31112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKC7"/>
    <dbReference type="OrthoDB" id="6049566at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="189" mass="22324" checksum="3E1069359F4B8BD9" modified="2017-10-25" version="1">MDTHNIPVPARLRNRSGGGGSLLIKRTFNTDYADLHLTWKDNHYDWLPGPKQIPKQLGQQLDKEFLDKLEVRMLDTALLDAYEYMQRYAVGLEQIAWDQEDHGLEFRKQFKDSEYNLRAVLCELQMALAERGVVPRPDVSRDIMSREYRDMSVSATYRNLRDWLIFRDYMNGLEYIIEVFNQFVQGIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLG6</accession>
    <name>A0A232FLG6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radial spoke head 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000046">
        <property type="protein sequence ID" value="OXU31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLG6"/>
    <dbReference type="STRING" id="543379.A0A232FLG6"/>
    <dbReference type="OrthoDB" id="423343at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF263">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36781" checksum="68C58978E499D014" modified="2017-10-25" version="1">MSEDESVEATESTESEVQNPLGSYEGERNKSGERHGFGRYLLANGDTYEGKYCRGLRHGHGLYVFKLGARYEGQWCRGQKHGRGSFVYPDGTRYEGEWKRDKRCGFGAYHYRNGDVYEGTWRQNYRHGLGSYTYADGGCKFYGSWVADRMQGIGQLTHQRHRHHGFWETNLPQGRGCYIFEKGSMLHGHFLHILDTSGQIVTEIDEASQELEISEDEPPREDTAVNAKELRPEPLKQGIVAVVWRSRRVTPYSPDLMPPEPAAVIDQESSVETLNDDVCDETDDERAEEYLKRDDDEVEYEDEYVDEEAEDEENDYLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLI5</accession>
    <name>A0A232FLI5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000051">
        <property type="protein sequence ID" value="OXU31525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLI5"/>
    <dbReference type="STRING" id="543379.A0A232FLI5"/>
    <dbReference type="OrthoDB" id="9991628at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="623" mass="71255" checksum="DD884C97AE33005A" modified="2017-10-25" version="1">MKTIERNETSEIMCKNKLFIVFLVQILYVAASDQLYRSKRDESYNRDLWSFECKDKSKRIETNYVCDCYKNCPDNSDEADCTEERCKSMGKLKCKNRDVCFHQSFICNGNNDCGDNSDEEDCTEKRCNELNKFKCKGVNKCIYHEWTCDGKNDCGDNSDEQVACTEKHCSDLGRWKCKTSNKCVRDIDVCNGQNDCGDNSDEIGCDKKRCTDLGRFKCNNTNVCIPYDSWLCDGIDHCGDNSDEINCPENNLCDSNGKFKCKDTNKCIDQDLICDGIDHCGDNFDETDCTEERCKNIGKFRCNDGLKCISDSLVCDGYDNCDDKSDEADCTEERCHSLDKVGCKDKSKCLEPDDVCDGRQDCDDNSDEIDCDEKRCGAISKFKCKSANKCIRRLYICNGKDDCGDNSDESIKNLVQHLPLKVSLNHRIIKTHLIYADISDERKFCSFECSDESKRISLNYVCDGYNNCQDNSDEVGCTEERCKQLWRLKCKNRDVCLDESAICDGRNDCGDNSDEENCTEKRCNELGKFKCKRVHMCIPHHWTCNGRDFCGDNSDKEIGCDEKRCHELSKFKCKAMDKCIRSQDICNGNDDCGDNSDERLESIVQHFTFNILLKHVTGHDRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMH7</accession>
    <name>A0A232FMH7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000023">
        <property type="protein sequence ID" value="OXU31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMH7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013189582" evidence="1">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="358" mass="41508" checksum="EF3E331041587659" modified="2017-10-25" version="1">MDLRQILLTAFTIIFIFFQPTLRKDTLEKLDDNSSEVLRKPYNVSVTVYDRGVPTDIKRKCCTIDVQSLELNVPLMIDPDDHSEFLYPDKDGNIHFNEGESVFLSCGTDVKKNYLISFPNIFYAEFFCACGELFYGNGHSVYSLKIYWRRTKYLPAIPNTPPSDIIKALDQDAQFRSFKVVQYRIEDSYPCNLLEPAYLVSPHLMVYTAAAVAAYDYLNIVPFWKCNVSHGLFSKLLIDTVSKRKVDMYLSAKSISDLIEKKFPVHTYAFKAVIDRVGRSGVVFVTVNDIHLKLDNFVYYCENPMTEMKGARMPYHWKLKHTGYGFSYMCSVADFQRSTNIYFHEDIYEDRLLYIPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMI0</accession>
    <name>A0A232FMI0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMI0"/>
    <dbReference type="STRING" id="543379.A0A232FMI0"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF237">
        <property type="entry name" value="MIND-MELD, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="13554" checksum="AA475E1F5E4FA6F2" modified="2017-10-25" version="1" fragment="single">VILFYCRGESFSGGESGIAVPDTMCSQKSVGISVDLNSYEPHLLAGTMAHMIGHNIGMSHDDGRTECRCHDWHGCIMAQSIVGLENVQPYKFSECSKSDYIGAFKDGKDVCLLNKPNEVILLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMS7</accession>
    <name>A0A232FMS7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Direct IAP-binding protein with low pI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Smac/DIABLO protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000039">
        <property type="protein sequence ID" value="OXU31667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMS7"/>
    <dbReference type="OrthoDB" id="6153032at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008631">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009062">
        <property type="entry name" value="Smac/DIABLO-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015142">
        <property type="entry name" value="Smac_DIABLO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32247">
        <property type="entry name" value="DIABLO HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32247:SF3">
        <property type="entry name" value="DIABLO IAP-BINDING MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09057">
        <property type="entry name" value="Smac_DIABLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46984">
        <property type="entry name" value="Smac/diablo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU31667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="227" mass="26157" checksum="2379FCC475A39F96" modified="2017-10-25" version="1">MAFRNMIKIFLRKFSPVHPVVLYATTAPMFTNPDPPKDPNNDQKLQFEPPSPSNLTYDFLIKQSTINAVNSASQALTVTYSAIENTSREYRKLLTRLIALMNEAILRDVTDSHWDEILEIRSQMQKKKHILMQFIGYMDYVHKMAEAASEISFLAGMDNLSTSLTQRIDDALVKIQTEKTNNSQLEEEYTRVQEESIKSSNKKEAYKKEKINVQDTQIIDLDNLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN12</accession>
    <name>A0A232FN12_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000032">
        <property type="protein sequence ID" value="OXU31757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN12"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11367" checksum="2929527C46A2BD7F" modified="2017-10-25" version="1">MARYAVFQIALFVLAFVCLIQAKDRIGTFRHDMVEDFVDRLMDTIKKEHITCESYEKFCETSNEQFQNSQDPKEKDVNSMAIEFCKAILKPYVCNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEK1</accession>
    <name>A0A232EEK1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005320">
        <property type="protein sequence ID" value="OXU16758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEK1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172507" evidence="2">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="138" mass="15506" checksum="0909BC756A4B1A7D" modified="2017-10-25" version="1">MRLLTALLLIGIVAVVNAKSGSTAFTVTQNDRNVFRNCMTKIGIPDDEMVAVLDNHEKDADEKVKCYNGCLYKAFKVIKDDGTVDTEAAIKFFKVEDMESDKNIIVKCSNESNSNKEKNDCDTAQTMESCYYKLKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEN9</accession>
    <name>A0A232EEN9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase A2</fullName>
            <ecNumber evidence="2">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01005248">
        <property type="protein sequence ID" value="OXU16829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEN9"/>
    <dbReference type="STRING" id="543379.A0A232EEN9"/>
    <dbReference type="OrthoDB" id="8187220at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="6">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU16829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="13668" checksum="7A47C811B5A5CE4D" modified="2017-10-25" version="1" fragment="single">QCIHGICNTSPFTRSHCDCDAKFRRCLQTINTEVANTLGALFFNVIQVTCFKERRPCSQWQSCKQSSYEWRRSQKYILPNEWSPRAAARNKVQTLNTIFQSFNAWLQQLISHNQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EER6</accession>
    <name>A0A232EER6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005274">
        <property type="protein sequence ID" value="OXU16802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EER6"/>
    <dbReference type="STRING" id="543379.A0A232EER6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="178"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="343"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="520"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="76897" checksum="ABBA6C562536EAAA" modified="2017-10-25" version="1">MAPKTKSKILGQVKTLTSKIKWHIHKFKTSCSQANVGDALKSPLFTTSVEKRNVQWYLMLYPRGRTQDNRDFLSIYLYSTMYKGQFEVTATLNILNNRTQVVVDCYLEGSELGEAVWGNHKLISTEFITDPQNSMLNDGDLVIICELLILPQYEVATFLSRIQVLEMFENLLNDSKFSDVSLVLEGKTIRAHKCILAKNSSVFAAMFDAESNERKEIVLEIHDSTYSILMEMIRFIYTGKVNGIENMIEDLAIAANKYALHRLMIICEQTMIKCLSIHNVIHSLLFADKLEMKELKAMAIEFIIASGSNAIDQENFRTLPMDVVLEVCSAAKTTTCGTVKTMDAKFEWQIPDFYTLCSQSKVGDVIKSPNFATTVGFRDVEWYLRLFPGGERQELQDFIALYLCNTKTVSMGKIVAKSNFMIRNSEAQVVVNHSMTESVFDSKTSWGIDQVIPKNFILDPANQLLTNGSLTIICEIIPMPRYLVKELKQNKEVHEQQPTLASRLELLDIYGSLIDDNIFSDVALISESRSVRAHKCILARSSSVFATMIDNEINKGKKEIILEVNDIRYKALLEMIRFIYTGKVNGIETMIEDLAIAAKKFALHTLLIICEQVMIKIMSIHNVVSFLLVADKVKMKELKAMAIEFVTMSGSNVIDQPSFKTLPSKIIFKICSNLANKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFC8</accession>
    <name>A0A232EFC8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005056">
        <property type="protein sequence ID" value="OXU17060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFC8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="32" mass="3897" checksum="88A789F35EF6A132" modified="2017-10-25" version="1">MADIDTWIQKSTARNIFRQPRHRRPLAPRHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFL0</accession>
    <name>A0A232EFL0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004989">
        <property type="protein sequence ID" value="OXU17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFL0"/>
    <dbReference type="STRING" id="543379.A0A232EFL0"/>
    <dbReference type="OrthoDB" id="6288751at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042378">
        <property type="entry name" value="IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2/IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15256:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN DGCR2_IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012330616" description="VWFC domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="66073" checksum="611C7A644273F6DA" modified="2017-10-25" version="1">MRYRAELLGYAVLTLTLQFNGQVLARGATCKDINGLLHETGYHYIPGPEPCTLCVCDNGNPTLCKAVLCKYKNQESLPNKDCKSFRFGDTCCELICLDDAISSTTNDKVDGNGTSVVDSSTNYDLGLRLVASCITALLSLGLLIFLIHRLRQRKIRAGRQNHQIADDQRSLGSMGYLDRNSVQHGMPMDDLPCNGNYPLWKPPGNYFPRGEAPPPYEEAVAAARAEQALLSISPHALSPLNFPNTYLTTHNAHANVSIVTNSQNGLPVSSPTLSTQNNATSSSPLIPTSNRPLSSPAAHNCYQLNQAESAAAADFCAGSCTTSFAGSSNNTYENLPTPVSRSALSNSVSNITPQHTVSSSNQLLLPNAQSAPVQNYQQHTTLPRQGGAFTISATLPNSNGATHRTIPRTLVTSGSLRLRREYPVHQSVAPLFDTPLVLPKNTPGDGNPSPRSTIPSTVIPSSVPSTLSSGDAAVRTNAFYDNSCSRDPSPSTSAKSSETKPAEIPPTLCNYKPPLATANEVNEEGSFDSVTCTCSAQALPPLHDDADDYRSECENCKSATGSRYYLDNEDELVTSPHETMTLQRRPEDAASNVTPQYYRTSLTLPTSTRQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH47</accession>
    <name>A0A232EH47_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004589">
        <property type="protein sequence ID" value="OXU17686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH47"/>
    <dbReference type="STRING" id="543379.A0A232EH47"/>
    <dbReference type="OrthoDB" id="10625343at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47162">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012104634" evidence="2">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="403" mass="45924" checksum="4DBA1FE24842DE0E" modified="2017-10-25" version="1">MFTKSLVLILLGCTLILASPVQQSGESRAKRSFIGTIADWLQKIDNTIDNVTDRVKQPVNKVYDAILKQGEGAVGYGKDKINQVLEKYYELKSKSEESINKAKNTFLTKVIDELQKVIDSLSESDSEDLEKLKEKTQDIAQSGKDALEKLKQQLQEAIEAEKLKLEQNLGQWEEEAKEAEKINQLLGKYYELKHKSAKNVNNIKNAFFGKEKTNQIAESGKAALENLTMFTKALIFALLGATLVLANPISQENSVEEHTEKSWKAKVGEWVHHVEDSLKEYLEQGKESFEEAVKELKQKGGKASEISKEKWAELKEKYDEVKEKAKVAIAENKKVWSARLEEWKHKGEVALEQGKDKYAELKEKAKEAIKDEKAKWQAKFEEWKQKAKEAIEAAKHKLNKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIG4</accession>
    <name>A0A232EIG4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004271">
        <property type="protein sequence ID" value="OXU18124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIG4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="10115" checksum="1EE15549E7532A81" modified="2017-10-25" version="1">MVRNRAPTSRGARRLAQGQQGVLPLFARPEEVTYNTWTPSPTNLKTIASRHTHTCTQIHTRERRDRRARSGTKFIKPINLHLHYLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIJ2</accession>
    <name>A0A232EIJ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004218">
        <property type="protein sequence ID" value="OXU18189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIJ2"/>
    <dbReference type="STRING" id="543379.A0A232EIJ2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="282" mass="32946" checksum="C27DFC9EF8C64D76" modified="2017-10-25" version="1">MNLLVNEIQEIIVGTGQGTRVEEQGFRTPQPCIRRSVEEAGNSKSTRTERRAKRGGGRGGCRIGNKLKQRKLEDSLKSKEETGVKRKQRSTLEQEEKNKKERAGEEEVNEYAFAKGGNVKRTPQEKEKMEDETTGSLKNTIDRSLQKVEEISIKMDKEKEEREDDGELGTEISKTGRKYEQENRGKEGILKYVGERRKRVRRECKEAGEREEKERETEKKDWEMRLEQEKKERREDLKKIIERGKMGQEVSWRLVKEKTRGRGYAEENVVIERKNKKNRGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJV7</accession>
    <name>A0A232EJV7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003931">
        <property type="protein sequence ID" value="OXU18637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJV7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="112" mass="13238" checksum="5D22C5034353B6D7" modified="2017-10-25" version="1">MSDKLLLLNRIRTQNSEYVARFSSDKSSDESDSSGEYSDKEELNESIFMSDLKKWFYNYNIPYSHLDALLKTLKPYHSELPVSSKTFLKDNEVQNAIKFKNSFHMIRQMNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK87</accession>
    <name>A0A232EK87_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003882">
        <property type="protein sequence ID" value="OXU18721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK87"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7829" checksum="E8A50E96712AC5A6" modified="2017-10-25" version="1">MQGKGLKERYRLSKKYIRGYTGDTLPLSHRVLEHTERREGVLVSWRERGDPYSSIGYQNTLRGEGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKA3</accession>
    <name>A0A232EKA3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003824">
        <property type="protein sequence ID" value="OXU18794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKA3"/>
    <dbReference type="OrthoDB" id="6598185at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF141">
        <property type="entry name" value="TRANSPOSASE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU18794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="777" mass="87833" checksum="8A991EC313EF2DF4" modified="2017-10-25" version="1">MTDMEGKAQKSANKKFCSVPDCKGQGASMFHKFPLDEAVKRKWIETCHITNPVTTNSYVCNSHFSEEDYSCLKPKRLRRFVVPSKNLIHEEPDFEEFDPEKEISGVKQNDPGAALPTFVKVDILSHKMHGDAKTAAEVLELEKPTMGQFKQIKRVCCISDCHAKSSQSTFFHTFPKLKRIYQQWYAACNLSGPVKYPLFVCNSHFRKEDYLNLDSKTPILKSNAIPCLNVPRKPKFRVVFKEEKNEKETSTTVAKYGKYMLIYFELSICITCSNGEDKEKVTTIIYVPKNCKSVIAADSEPVQVVKALDNKNKSMPKNASNVLQNQNPIKSNAITKNQSEVVVQQKQSTDKGEQPNASDNEVEITSVLIKNDSHNHKPNSTVRTKEEKKNTVPKYLQVANERIKKNVSAITLCAGCGQYTTVNDEDLIDIKKNPETLAAEALLELQEVHPPNEDERTVITRKGIEICDRVIRKKRFSLLGLLNNDSELMAFTGINIALLDRLANAVTSAEGPKCVAKISNPPRERIVLCLCKLRTNLSFRSLAAMFGLTQIVCSSYFFAMVRTLAGILKHTIYWSKTEELLKNLPEAFQSFKQTRVILNCTEAEIEKQRCPKCKYELFEKKIEYESVKFVLGVAPNGLVIFKSKTFDAQGEDTSVFTQTALLESLDPMKEAIMADNSLNIEAECVERNITLIKALRFEKNKQYSAKDVELIKNVCAARVHVDRTLQRIKMYKVLQTKISWRLLPYLDDICTIVAGVVNLKNPILPDDVHLAQAGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELD4</accession>
    <name>A0A232ELD4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003591">
        <property type="protein sequence ID" value="OXU19141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELD4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="51" mass="5850" checksum="3FF8D04A842D3C40" modified="2017-10-25" version="1">MQAIIPLQSLMAEYEEYIANTGRDTWHDEDNDEVAQINNAFISSSDDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELE1</accession>
    <name>A0A232ELE1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003576">
        <property type="protein sequence ID" value="OXU19165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELE1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="45" mass="5347" checksum="F158160D55DC1997" modified="2017-10-25" version="1">MTLKCRLNKNCENIVNKSLDTKNLGQKLSRRVYSVVMRTFLHCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELH0</accession>
    <name>A0A232ELH0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003573">
        <property type="protein sequence ID" value="OXU19168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELH0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172503" evidence="2">
        <location>
            <begin position="20"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="644" mass="72791" checksum="193B62DEC7018906" modified="2017-10-25" version="1">MTVLRLVMVAAFLFSFVIADNGNFMRPSGQPFRSSQPQPNSNHRDLYHSYDTSNPWTSRRIAENGPDSGPPLDIPDSIASSNSPPSRYIQRFPKPVDSNDDMMILEPMPRHRESSWTDWMPDFFGDDSPPGPGPLIGPMEFPGIGKKVFIRQNEPLDEDTNRVVIHLINRETPPTYGTPVSHQSHPPQQYNQQPYYTEDPMKQHDRHYGDSFTSIRKKNTTWRWHSLLKNFLFSSNYMIPGKSSVIQQNEYPSKMTSSDPWKLSGTAPDKEIKDKKTSYPTHDRLLEVPNDPRYSVMLLKQSGSNIPNVIWTLIKTVETKQNSRPPDHRGNYYGRSLDSTESKDPATFPSTNNSSSASDKQSNLPQSKASGKVLEQQHNTLRRYGYQNNNRSPQYEIPRFKQPLNHLDEITLVNKAELNRRRGGGFAPFFDGSPIRTPRHHQYSGTKHFARSLPPPIRQKLPAAASGGLQVIPAPNLQRGPLDSDNSTGAKPNKNSTGEEVMHNIMSMTASQSWKNITSRSPKMIGEKNAIETEEKKSTTSKPEAVAVIERRIDEESTIEEETKEEQAPTESVPIVSSTAAPVVANKTDKAQAKMKEAVQKMMGSFSLWRHKVVSTKFLKELEEKQKHKKTKSSKKSETDAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELX4</accession>
    <name>A0A232ELX4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_015966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003467">
        <property type="protein sequence ID" value="OXU19363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELX4"/>
    <dbReference type="STRING" id="543379.A0A232ELX4"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000459">
        <property type="entry name" value="ARM repeat superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="938"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115145" checksum="8F30FB7281A8F318" modified="2017-10-25" version="1">MSGSEVQGSLKEALYETLSGILAAERDDRQAAEQRLTALEVTEEFGVHLTEFVVDPNGPLAIRQLASVLLKQYVENHWSPLAEKFSLPEIKTHIKQTIKSLLPLGLRESISKVRTAVAYAISRIAHWEWPENWPELFDILVGYLSEENQFAVHGAMRVLTEFTRDLTDTHLPNVGPVILQEMYRIIQSDTKYSVRTRGRAIEIFTTIASLVAETGVYSRGFIEQHLQPVIPMFCAKFLEFLAVPNGPTSDSGLKTEIIKSINCLVTKLSKYMTTFVPQILPCIWTTLTQSAIIYQEEVVNGDGEVNDQEVDSDGEVINFNNLVIAIFEFIGTLIDHKKYSNLLNNFLPDIMYYTILFMQVTEDQMDMWTNNPNQFIEDDDQYATVYNVRISAQELLGTLLSYSEEAAVNALCGAVTRHIEAANNPQSPNCVTRDVGTIWKIYEACIVSLNIAKESIIEQQQSGKLQFDIIRFLDTIVLATLNNPAAHPLLLGRCLCIGGRYAKELPPEMSARFLEATVNGLLETQPICIRVSAIKAVYWFCDAAIIENSPLLSILRLQLPAIFQGLFTLSNQLSKEILILVLNAYSVLVPIDPAFTASIENKICPFTIAAFIKFHSDPEILNLCQDIFKELSEILDCVGPLQTRLVPTLISMMNITAMDKSNDDGIRSVALDVLEVLVQYSPQPLSNILIDNAFPAACHCILDSTDNGTLQNGGEVIRTYLSVAAHQVIEYTDSEGRTGLQFILQIIAQLLNPQSSEFTAAFVGRLVTTLIRKAGNSLGGNLDLLLKAVLSKMQRTETSTVMQSLLMIYAHLINSEFDAVLNFLSTVPGPTGESALAFVLSEWVNKQQLFLGNYDRKVSTVALAKILEYGVTHDDSRLNEITVEGDQVPSENESSGVRTRGKSQSKPMQWTTIPVLVKIFKLIIYELGHYFEAHSAEQENEESEDDDDVDEDAVIDPGNDINQLLMENFEDEIDEEQDPDIRQDSIYNLNLGQYLRDFLQNFSTHHGFPIFAQHLNVAERKILNSINIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM23</accession>
    <name>A0A232EM23_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003452">
        <property type="protein sequence ID" value="OXU19396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM23"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="207" mass="23257" checksum="182F3A1DE2ED7FAA" modified="2017-10-25" version="1" fragment="single">MALNIYAEIDCYVPRYGIPVIKTRYHGTVGMTTKNHYPRAHFQPVLQHERINRQIASSTSGFQTNDTIKKCLEQGDVEDVQGVLARDGREELATKNNTAVLLSAREVEVMKGDVKIVDFAEPKVNLAMPDEVSDSTDRGFAASEESSLGRAMFRRSSAENVLPPKEPRIRDIKQRIFDRLATVNDGPELQRILTLVEGMLKEGLTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM73</accession>
    <name>A0A232EM73_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003407">
        <property type="protein sequence ID" value="OXU19459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM73"/>
    <dbReference type="STRING" id="543379.A0A232EM73"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="227"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="408"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="592"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="786"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="129900" checksum="DCEC725B8FF24B42" modified="2017-10-25" version="1">MALGGGLGGVSRSRIKTTSHQNTKGLVKISRRYFVHIVSITKMPIVGRIDCEIQTYKYTWQFDDFKLRHLEPGEKLRSPKFEATFNGKEFEWQTRLSLSEVKGSESVTIALYTFSTNVITANVSFGFVDTDNKVVQFMSTNKQRHDIRHKSEAIWAIPDFTHKSFVSRDNNLIHGFSKVIIECEIHVYATCAKEREKKELMEIEQDNVLRFEEFDKYEHLLNNDAFSDVSFIVEGKIFKAHKCILAKSSPVFAAMFQHEMREKRENVVRINDMRYNVFVEMLRFVYAGKISLYNYGVKSTSEELLFAADKYSIDGLKEKCVKLICDDLCIDNAVDILMLANRHEVQYLKFRAMKLIVLHSYELNKIPYFELLISTPNILYEVCHAIASHGNHNVVGNVVSDIDAGNKTYNYKWIITEDNFHANYSTHYNNTRVRSPKFTTTIDYYKFEWQLSLYPEGIGRGNKEDLNISLYNYSNCIVTAAVSFSIINTKGRVIRKRTINMATYNTQLVSEANWRVEKFIERSFINENENEIFYNGFLTIQCEIIIYETCAVELLKEGNMEHSDQEDDLSVNEERLEQLDKYETIMNDDIFSDILFIVEGKTLRAHRCILAKSCIVFAAQFKCEIRKNQESKILVIQNIRYKVFVEMLRFVYTGKINIEINNANVKSIVSDLSVTAGVYCVNGLKRMCVKLMFEYLRIDNAVEIVKLAERHQEKSLKIRAMQVIVCNLNVIDKITDFNTLTETPNILCEICHCLAKIKIVFVKFETVEMVTNSHDAVGKINSELQSYKYTWAVDYLDFNFKKSGEKMRSPKFKATVDATAFEWQLWLYPKGVKGYHGKSVSIALYNFSKNVVTATTSFGFVNDENKVIGTKITEKKTYNTQNDAEAMWGFYDFVDTSFVSNRENGLLHNSLKIVIECEIKIYASGDKERANQEDCVREEEKTQRLEEFDRYENLLDSSAFSDVSFMVEGKILHAHKCILVKSSPVFSAMFNNEMREKQERMIEIEDIKYSAIAEMLRFIYCGKINLEIDNTELSIGDLLFVAHKYDIDGLKDKCEKLMGKNLSNDKVVDILKLADRHNASNLKSKAIKFIVSRSSNVLKIPNFKTLTNTPDLLCEVCLAIAYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM93</accession>
    <name>A0A232EM93_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003411">
        <property type="protein sequence ID" value="OXU19457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM93"/>
    <dbReference type="STRING" id="543379.A0A232EM93"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF34">
        <property type="entry name" value="PROTEIN LETHAL(2)ESSENTIAL FOR LIFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19165" checksum="76EAB9F1DACD1353" modified="2017-10-25" version="1">MALIPTMFRDWWDDLDRPSRLMDQHFGMGLTRDELLQTLSVPSFRGYFRPWRNLLEQTGGVSRVQSDKDKFQVIIDVQQFAPQEITVKTVDNSIIVEAKHEEKKDEHGFISRQFQRRYVLPEGHDIGNVQSSLSSDGVLTITAPTLALPAPGEKIIPIQHTAAPAVKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMK2</accession>
    <name>A0A232EMK2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003343">
        <property type="protein sequence ID" value="OXU19585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMK2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257666" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="113" mass="12881" checksum="79F0F959FFC6C075" modified="2017-10-25" version="1" fragment="single">SLSLSLSLSLLLSHTLSRVHLRSRVLRRNHRIKTRSRARYAVTAEAEFPRRRGCCSTISSCLRSRFSLSFVLSLCSLTLTSILSLPRSPLCSFHDRVRESPNSEYLLSFRLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN09</accession>
    <name>A0A232EN09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_011904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003242">
        <property type="protein sequence ID" value="OXU19745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EN09"/>
    <dbReference type="OrthoDB" id="9451254at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016348">
        <property type="term" value="P:imaginal disc-derived leg joint morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000958">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002020">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000254">
        <property type="entry name" value="Odd-skipped related transciption factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF13">
        <property type="entry name" value="PROTEIN ODD-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU19745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="216" mass="24853" checksum="3525D049B509F12F" modified="2017-10-25" version="1">MEPLTPPHTPPHSTGTLRWPVPHPQQQAAFLXXXXXHPLAAAATLSQPPPPASFLSRRLPGQRPKKQFICKFCNRQFTKSYNLLIHERTHTDERPFSCDICGKAFRRQDHLRDHKYIHSKEKPFKCGDCGKGFCQSRTLAVHRTTHMPEAPHKCPVCSRSFNQRSNLKSHMLSHTDVPQDLRVEQQSSKPYPVRTTLPQQQPMPKLGFTIDEIMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN21</accession>
    <name>A0A232EN21_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial ribonuclease P catalytic subunit</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mitochondrial ribonuclease P protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_009704</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01003227">
        <property type="protein sequence ID" value="OXU19764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN21"/>
    <dbReference type="STRING" id="543379.A0A232EN21"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030678">
        <property type="term" value="C:mitochondrial ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18718">
        <property type="entry name" value="PIN_PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033495">
        <property type="entry name" value="MRPP3_PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRORP" evidence="16">
        <location>
            <begin position="292"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU19764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="534" mass="62392" checksum="F3341A474DB8ED24" modified="2017-10-25" version="1">MMGLFIRSSTRLLQCAKCMLSTNVAMSSVIANPVNRKRINNQHIFNEIVESDSLIIKKMKSNEIMQDEHWAAARKDLLETYNLTETNVDSKIYNLCQYYNRLDEAVHYFHFLERNNYEIPLIITGEYLRMFYTQDKTVTAEEEEEICRVYDNLRKKYPLLDAKTCSSCILALSLTKRWKETLELLEMMKITSNPGQSVMSAIISAAFRNQEVPMGWTIMTEVIERYPLEPRVYKDYLTHILNKVDKSKLQEEMEKMFLFWGQHDIKPTEEVIMKYTNLYESFGYTAKPTTVSKRGECSYCSQVLQATTLSKSDFKLLSTSVLSNLIIGKNVFCASSPQELKRYLLFVRTMKPYDVVIDGLNVAYGARKANEPGSLQSVLNVVNYFYNGRKRVLVMGRAHMNWWSKETMKAIHEKADVFLTKNISQDDPYLLHVTLLSGPQTYFVSRDLMRQHKAKLDDVNLQIMFRRWQLSRQYKFTKEHKSHFVKLIPPLAFEISAQKNKANWHMPFSTSHDLLLPQEYTIPPNWICLSKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENA1</accession>
    <name>A0A232ENA1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003203">
        <property type="protein sequence ID" value="OXU19802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENA1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8470" checksum="F8CB5739DEEA6B30" modified="2017-10-25" version="1">MYTPYWAQVKESQLWVFSLKEHAELEWKRIVCGHDHLTVHATGTLKLQPGCKAIANNYQLFTNAAMSLTPIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENH6</accession>
    <name>A0A232ENH6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003136">
        <property type="protein sequence ID" value="OXU19923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENH6"/>
    <dbReference type="STRING" id="543379.A0A232ENH6"/>
    <dbReference type="OrthoDB" id="10249775at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="251"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="527" mass="60990" checksum="60B0DD7D339415DC" modified="2017-10-25" version="1">MDAKDKKSELHKTAKKLTEDIQNMANYKNLYNEIQRLVASSAVKKEDFKNTLFEALKTEGLETELRNTVFHWSRSQRLSESRENVNEYQTDLSYLKKAQIQWERRIQKSLNSMCNELNVPLARIRPSADREELSEKWNELSTCDFDISQYRPLYAPKDFLEVLFSVRDPAFKKQPNEPNWEFSHIQIHVKTLAQLRETYKELSQGVALLGVNGNIPSAGNYPNLEAERTHLGEKVLISNHAPIAQEFLKRGAPRALRGKLWSLVLGSIIRESDVEYYEELKGMVLQYDIMVDKLIIKDVQLTASNDDQYFVFEDVLYKTMLSFSRDSEVLAPVTMDKSAGGQVIHAVLQGKPATLENTLVFPPSGVIPFHGFTMYATPFCYLYDDPCAMYFTFRAFYLRYWFRLHTVSSHEQGIVALCLLFERLLQCHEPQLWAHFRNLHIQPIKIVFKWLMRGFSGHLPPEQLLYLWDLVLGYDSLEIIPLLAVTILSFRKENLMQVKTLHNVEAVLADLSSLKVMPLLQLSLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENN7</accession>
    <name>A0A232ENN7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003120">
        <property type="protein sequence ID" value="OXU19947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENN7"/>
    <dbReference type="OrthoDB" id="7554092at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7019" checksum="E4844F633693AC23" modified="2017-10-25" version="1" fragment="single">VCPGSDSDFVWVRGDNVTYVSCYLTPNEDIGGFQEKLDALEDVVREVEGELIVARDFNAKAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENV4</accession>
    <name>A0A232ENV4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003055">
        <property type="protein sequence ID" value="OXU20043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10663546at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1282" mass="146077" checksum="534C1D8F773B5775" modified="2017-10-25" version="1" fragment="single">QQKGAVPILAASQGIPRVFRDATSDFKRLITGEYNVALDIRDQTPQWFTMSTPKISISLVILCFFLNTTSAEERIAYRKHWDFPTGSELFFNPKTYRISDEYHNLIYVVCDVRDDLRKSVRNCTAVQDTRPERSCPVTLQTFDKEEHFRYQSDYLEIFPFGSTRAVIVWPDSRGPWFLKCTILDFTTCKSKDVLLTGCDDYIDQAYFVAYDDSFELVIKSCSQGRHDKYHIDAEGNIISDLVHWKLPQYRVFSAAASNRAIVKDNKAKAYLHLAVHYTVDGERVTQMLLMKPYGSMTVVRKVVSTAHEKIGVAIPYDDRVDLNTSVPYDIKLAYLALRNLADGSKNRENGLFKPDTYYLKKVDDEGRVVGTVNMEPESKCEGKESGHQVFENGTTEYCVATACGDEPEIHGELKFLNLIFAQLDTSVRCVIRSRVQFGASQLGRWLGFVLFTVGYKGVVYENPDTYISTKVVGTVENKLQSNREDKGNEIETCPGGRFGGKSIALLAIICFFANTIKAEERIAYKKHWDFPSGLELFFDPRSYEASDEYHNPTYVICDKPDDLQSERNCTAVQDTQPERSCPVTLKNFTADGDELAIYPFGSTRAVIFWSKRYSLSKRSTIKCIILDFGTCESIDVLLEKSFDRIRWTYFVAYEDSFDLVTISSTIKNGHNKYHVDVEGNVTFSSWKNYLNMEQFTSAAAYRAITADSKLKVYLHFGKSFFDVSSTITSLVKPDGWRKVLVVTKKYWNTAFIRVESTAHETIGIAYALENVIEVSQFDQEGELKLNTSLTYDVKEVKSLSLLNLADGGFLLSTIGSNDGNPDAYYLTKVDARGKVVGTIKKEPEPNCEYKPPSLRVFDNEAKEHCFVIVCHDHHTLDLVVKSFSDEDFSDEKSIALLAIICFFASTTSANERIAYKKHWDFPYGSKIFFNPKLYRQNDEYQNLAYLLCNVDHDRKFEKNCTAVQDTQPERSCPVTLKDINADDDLEIYPFGSTRAVIFWSKQVTEGLPITCIIVDLGTCKNKYVFLRESIFSIRWAYFAAYEDSFDLIVSNSFNIRNKYHIDLEGKVTFSQWTNQELSRMGFGEEDYRAIVVDSKLKAFLNFGYSFSIFDRYSIVMSLVKPDGWSKVLAVYHDQIGDFQKVESTAHEKIGVAVVDNHRVNVSQFDQEGELKLNTSLTFKFQVRYLALRNLADGGFLLFAIGYGGNEYYLTKVDDQGKVAGTIQMEPERNCVGETPSLQVFDNEAKEYCFVVACYDDATIFAKLDLVVRCVSDEDLYKSEFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP84</accession>
    <name>A0A232EP84_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_007395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002995">
        <property type="protein sequence ID" value="OXU20151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP84"/>
    <dbReference type="OrthoDB" id="7179992at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="377" mass="44343" checksum="E072041AF2B56B80" modified="2017-10-25" version="1">MRIHLNAKIAYQYLRWSATLMATWPLSDATKQYRNVFYNMLWWLYLTNHLINLYLTLNTIITHNKNHLTVFYTWLEISFVTENIIVLISYKLQETKWKQLLYTSKMTINRTEDNIRLENSDLYPKVFVALLISFIVIVVSYVNKAETYERGLIMTTRYPFEIKSIGLKLFINLSQLITLLHASSILITDAIVVLLLYTCTIRLKIVEQKFKACKYYRHLKLHIHEHQKTLLLIEETNLLVSKTVLKSIALFMSYSIGGGLVLYNKNTSSLQLMQICLVICVIYLRVYVCAEIAEKMISTNESIGFTIYFTRWYEESAKDINAKNIIIQRCQKLPRIYINGFMQSLNRSYVRMITYATFSYFMAIRKIINKTANCVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPE4</accession>
    <name>A0A232EPE4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002955">
        <property type="protein sequence ID" value="OXU20224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPE4"/>
    <dbReference type="STRING" id="543379.A0A232EPE4"/>
    <dbReference type="OrthoDB" id="7713307at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="453"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="669" mass="76589" checksum="92F9898C8FBDC581" modified="2017-10-25" version="1" fragment="single">MSNSVCKRRKIKIIRIKDDSVRNVFVEDDKLKKITIEDYFSGEGNLTYKDENGEICFLRTDEQFFYLETGIDTYIFNEKQNSTGRLEKNKKRQLNDILEDLYKQRDPDRSSKKLTKTKISNKKQKLDSSSSNDEEECLKVSRTKTVEFLNRNIKVGWRHRVDSQSSYKYMGASIGPTVLLHLNGREDYPLDKLKQCLLEKYVTEANKAFFYNSSVEVGNSSCVVIESYYHDGKLRNFWEYCRLCLRKSNHALTVYLLTTEKPFNLSDFPDCSFLKQDYRNKITDSTSTSKGTIASKASVINKNMDENTHAINKTDKSNSNILMNKCDYCKIISNETITSKAMDKSAEEKVTNAETTVSKIFKIPTMSKICAQNNEKESRAMKEININVLEDNASNESDIEKSIGSPAYSQLTTEKKSTDCDSIESYFENARYNTFDIKKLKLSIPFIKEKDIEFSGIMLGSGAQGIVTKGKYRGSSVAIKSVQKGRNDNLIFKEVQLLNKIRHPNIVSIMAWTTSYTQFHILMELFESYSLFELLMDPKIKKLHKLTVRDKIQISQQIACALTFLHLHPEGIILHRDIKPGNILCSVPSCKIKLCDLGLGKSTIVNTSFQTVRENAMRGTYLFMAPEIILENKSATTATDVWAFVCTMVELFSEKSVWPIEEFDNGWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ00</accession>
    <name>A0A232EQ00_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_015596</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002835">
        <property type="protein sequence ID" value="OXU20469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EQ00"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000048">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="480"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="674"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="1327"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="206"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU20469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2129" mass="242173" checksum="C5469558D2A575DC" modified="2017-10-25" version="1">MADAAARQLQYEYKANSNLVLQADVRLIERRSRDEATGEVMSLVGKLDGTRMGDRAQRSKPGKAEERKVKRQKRDEAQYEFTHNKGATVLSDGVDEMVGIVYRPKTQETRQTYEVLLSFIQEAIDHQPRDILCGTADEVLAVLKNDKLKEKEKKKETELLLGSLADERFALLVNLGKKITDFGTDEKTTTGEENIDETYGINVQFEESSEEDDEDVYGEVRENEDEGDEGVEANEDRAIHAENLGKAEETKKEKPLHPRDIDAYWLQRQLKAIYNDAIVSHGKAKDVLEVLKTSVDCENQLVLLLGYDCFDFIKMLKKYRHMIAYCTMLASSQSNNERQKIRKKMSEDPALSKILYQLETGKGDEGEETIEAREQRHRREEIEDAGGPGGLVPGTRNVIDLEDIAFAQGSHFMPNKRCHLPDGSFRKQRKGYEEVHVPALKPKPFAENEKLVSINDLPKFAQPAFEGFKTLNRIQSRLYKCALDEDENLLLCAPTGAGKTNVALLCMMREIGKHINADGTINADDFKIIYIAPMRSLVQEMVGNFGKRLASYNLTVSELTGDHQLTREQISSTQIIVCTPEKWDVITRKGGEKTFTSLVRLIIVDEIHLLHDERGPVLESLVARTLRNIETTQEDVRLVGLSATLPNYEDVAAFLRVKPATGLYYFDNSFRPVSLEQQYIGVTEKKALKRFQVMNEVVYEKTMEHAGKNQVLIFVHSRKETGKTARAIRDMCLEKDSLGQFLREGSASMEVLRTEAEQVKNMELKDLLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKGTQVYNPEKGRWVELGALDVLQMLGRAGRPQYDTKGEGILITNHSELQYYLSLLNQQLPIESQLVSKMPDMMNAEIVLGTIQNVRDAVTWLGYTYLYIRMLRCPNLYGISHDKIRDDPLLELHRADLVHSAAMALDRSGLIKYDRKSGNFQATELGRIASHYYCTHETISTYNQLLKRTLSEIELFRVFSLSSEFKNINVRDEEKLELHKLMERVPIPIKENMEEPSAKVNVLLQAYISQLKLEGFALMSDMVYVTQSASRLMRAIFEIVLFRGWAQLADKCLSLCKMIDRRMWQSMSPLRQFRKMPEEIVKKIEKKNFPWERLYDLGPNEIGELIRVPKLGKTVHKYIHQFPKLDLSTHIQPITRSTLRVELTITPDFMWDDKVHGASEAFWILVEDVDSEVILHHEFFLLKSKYAGDEHLIKFFVPIFEPLPPHYFLRVVSDRWIGAETQLPVSFRHLILPEKNLPPTELLDLQPLPITALRNSVFENLYVEKFPQFNPIQTQVFNAVYNSDDNVFVGAPSGSGKTTIAEFAVLRLISQNPDGRCVYMVSKEALAEIIYSDWAYKFKSLGKKVVLLTGETGTDLKLLAKAQIIITTADKWDVLSRRWKQRKNVQNIQLFIIDELQLIGGEEGPVLEVACSRARYISSQLDKPTRIVALSASLADAKDVAQWLGAPAAATFNFQTSVRPIPLELHVQGINITHNASRLAAMAKPVYNAILRHALRKPAIIFVPTRKQARLTAFEILTFTAAEGKPTQFFHAEESDIKPFLDRMSDKTLKETLAQGVAYLHEGLSANDRRLVEQLFDSGAIQIAVCTRDLCWSLSIYAYLVVVMDTQCYNGKTHAYEDYPVTDVLQMVSRANRPQEDDDSKCVLLCQSSKKDFFKKFLMEPLPVESHLDHRLHDHFNAEVVTKTIENKQDAVDYLTWTLLYRRLTQNPNYYGLQGVTHRHLSDHLSELVESTLSDLEQAKCVTVEDEMDVTPLNLGMIAAYYYINYATVEMFDASLNAKTKIRGLIEIISAAAEYEAIPVRQKEENLLRSLASRLPHAPQAQRMADPHIKAQLLLQAHLSRIQLGPELQHDTELVLNKSIRLIQASVDVLSSAGWLAPAVAAMELAQMVTQAMWSKDSYLKQLPHFTPEIIKRCTDKGVETVFDVMELEDDVRNRLLQLTEQQMTDVAKFCNRYPNIEMAFDVQDKDRIRLGDTVNVVVQLEREDEVTGPVVAPLFPQKREEGWWVVIGDPKANQLLSIKRLTLQQKATVKLDFLAPAPGQHHYTLYFMSDAYLGCDQEYKFSINVGEYMSDASSGSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ72</accession>
    <name>A0A232EQ72_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002820">
        <property type="protein sequence ID" value="OXU20500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ72"/>
    <dbReference type="OrthoDB" id="7696379at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18310" checksum="C3B9A5624B3A9D6E" modified="2017-10-25" version="1">MIIEPSEIIEQLKETRRIEANLTDSTVRQKLYNLRKSKGEKVTVFCGKFDNLIRQYETCNKIIGEDEKRAIFEHAVTEAHPDLPTAIFVKNQTGTVMTTNDMKSFLLQLEAKNQINLEAKAATLLRQQHKAPANDPELAKVKCHRCNKHGNYQTDCPLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQP2</accession>
    <name>A0A232EQP2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_000817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002716">
        <property type="protein sequence ID" value="OXU20709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQP2"/>
    <dbReference type="STRING" id="543379.A0A232EQP2"/>
    <dbReference type="OrthoDB" id="7684415at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="66974" checksum="8C2C2300DACE32EE" modified="2017-10-25" version="1">MAPTPIKKKTGHEPKGPGGRPKHEVWTLGFRRVLKHCDKTQRTVHAAFCVICNKVLCNTAAKRLAAHRRICSLDQTDETELLDKSESDSKMKITKILSSDDSGTVTFVDMDDSAPFVNDQTTSEISKNEYTFLDSVDSMEEFRIQATGSTMTDSKLEMALAKFFIGCNIPFSVAESSYFKKLCLTLNPNAKIVSSDQLSGALLDNLYSKFHKDVKVGATSVLLIDEWKDENTNTNNVTVMIKTESNETIFLDNYELSSSMDIASELTDITKTSIVEAYDQFKTEIYAVILGNSCSLVKMQAASEVWQFPCNLHVLKLLTKEYVSQDFMNTLCKILKQLNTVFKDDELENKISSDQRWLNSKCILDYCIANLGTIQAVLSAENTIKLSKEYKSLFLDEDFVRKLESYNNFLESVSELSLVTQMPKSSIADTTEQWLSLQITEEDPELAQRLHARREIVMNVQCLVANYLHPAYRGRRLTDDQMNKVEEFLLNELDSEGLNSLQLYVNEDGIFRVLNQKEGLSAQTYWSLARRTHSDLATLSLKLLTIPATISTNYSRICNTIKNSSLKPDKTRKLLAVYYHLMEKEERIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER66</accession>
    <name>A0A232ER66_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002666">
        <property type="protein sequence ID" value="OXU20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER66"/>
    <dbReference type="STRING" id="543379.A0A232ER66"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000003">
        <property type="entry name" value="AN1-type zinc finger protein 2B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="209" mass="23129" checksum="968B991BB7D78229" modified="2017-10-25" version="1">MEFPNLGEHCSENTCNRLDILPLKCDACASIFCTDHISYVGHTCPSAYKKDVQVPTCPLCNAPVPSKRGDPPDLAVSLHIDNDCKSDFGKGRRKIFTNKCSSKGCKIKEIVQVNCADCGKNYCLKHRHPTDHSCAGKEESIRQKRLNALSRPAQNSSGNNSNSFRSLQGTMSEDEALARALQASLQDEHQRPAVQEPVPWATRDRCRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERR4</accession>
    <name>A0A232ERR4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002589">
        <property type="protein sequence ID" value="OXU20976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERR4"/>
    <dbReference type="STRING" id="543379.A0A232ERR4"/>
    <dbReference type="OrthoDB" id="6022711at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324">
        <property type="entry name" value="IL16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11324:SF16">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="643"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="834"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="938" mass="103911" checksum="4E871B85861C5155" modified="2017-10-25" version="1">MKLRPLQERRNMRLFKRRSLDQSPELVSATSISQDSQHQMERAVTIATTEEAVKTATLTVLVTPRRMKDEAKSAKKQQSSTSSFSAGKSKFLGNAFWRNLTSKTLIRPFSPTGLSSWGKKVGQKWDQLRRADSSEILSVSGRRRRWSPHRKSCADPLDEAKKSTAEPTPSSSPEFTKPKRISRVESLRNLFKSSTSERSSSMSKKSSAIKEEDESSYRMEKSLSEGALKHRPSPVGGDIDELANKRWQISRSIHDLEQKSRMLDYFLMNQAALTTSEGKALAKRTLQETTAAHRLMPTSGLMQHRQRRDSADSEEDLNSSNASSSSRESAVENVKRNLFNVRSGVNEDRCEPMKTSVISDIENLMSGLKLTGDESGYDSDSTRAGADSPDSEKSVGAPLFKPRSFSLDDYPGIDLSLPFSTPKKLQRQQTLSEENVTADHDKSLSQQEFDEQETTLLANGDSLNESSRTDTTLLMSEHDECDDEFAEIKLKPSSSNLTSADSGVVLDFLGPNSVQYRTPVKKRPESAPRTAHKSNKLGSLQKSLKPVQRKHSNVSVINLLDNAASPCQDSPPASKAVSALSSKSQLQYLNPKRAHSALEIEALESPKFKRPELNMTPQPLPRASASTLSATTKTPLIRRELKTMKLQVERCGSLGISVQRCDAVRPYFVISEMEPQGDARKSKMFRVGDEIVRVSGRRLRGMSLAEAKNALKNCVGSVELQIAREPNFFFGGELGDTWGCEEEVMVRSKSDSDVWGPIAKEREEEEQRRLQQAEAKTCEIIGAVTKDGRTVSAQDMECEEQKVTGMKKFQIRKRSSTIAIGSRRATSLSMDLLTVTLEKGGPKRLGFTIVGGADSNKGRMGIFIKDIMAYGQAAEQGVLKVEDEILAVNGVSLDGMTHARALQIFKTAKKGKLVLYIGRRDSSHKRSLTLGTQSSTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESJ7</accession>
    <name>A0A232ESJ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002428">
        <property type="protein sequence ID" value="OXU21287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESJ7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="8229" checksum="7FB7AD7BB6612252" modified="2017-10-25" version="1">MHMSMNGTYGSEEEIIAFVRIKSQSEVFIHLTKKWNQILFKIKKTHIRFNTFVEFVIRDLISRKIIQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESS6</accession>
    <name>A0A232ESS6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002381">
        <property type="protein sequence ID" value="OXU21401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESS6"/>
    <dbReference type="OrthoDB" id="6509516at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="722" mass="82938" checksum="1B717E33C266D209" modified="2017-10-25" version="1">MMIMMVFSDANDDDTVIIDIEDVENDSDIHFKDSDSEESVLDLLMFKESNLLVRDVVTMISAFSLRFSVSDEGRIQLMDMFKLAAGPKFEHCKISKYRMEQCVPNQDEYMTYYYYCSKCYNQILYSINAANYKLKTRNVVCEKCEEKVVLSNTKLLNDIVRNLSFRNDNKNSKGIITDIYGGEIQQKIIQEKNTKNLILLNFSTDGAPLTKSGKNSFWALQVTINSLSPKLRYKNILIAGMLIVKREPNPNLMNLYMSKFVDQINLLYENGISRRIEDTDITFNHSNDVAFALKNNKITNGVKGDSILNKLPYFDLVWSFSYEYMHGGICLKGDSILNKLPYFDLVWSFSYEYMHGLLLGVTLQLLNEWKNGSTEYKIKKKLIEMIEKKFLTITPNKEIHRLPRSGIIAGSNKAKASELRSWLLCYSLPCLTGTLHPDALNHYSLLVKSSYTLLKSQITENELKICEDDLTTFVVNYEMYYKETSMTFNVHTLLHICDSIRKTGLLCTNSAFPFESNIYNLKTFVNGSKGMDRQIARKSLQSLMFKTGDITSNSEKSNNFCANLFNPQRLKVYYDVGGAAGNVENVTYVGKGIRVNNVKDFPNCIAYKKCIFNGSVYHSTQYKRAKKTNDTTVLLKDDRFATILYFLKTQNDKRCYLKLSILNVPRSNPFSGIYHIKKVIRTENYNDSIVILPIDSIEKKAIFVDLNCIQYVCTLPNNIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESW2</accession>
    <name>A0A232ESW2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4'-phosphopantetheine phosphatase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inactive pantothenic acid kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_006573</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68340"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177302"/>
            <dbReference type="ChEBI" id="CHEBI:177303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:68341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with PKM.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002386">
        <property type="protein sequence ID" value="OXU21386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESW2"/>
    <dbReference type="STRING" id="543379.A0A232ESW2"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1700.10:FF:000001">
        <property type="entry name" value="Pantothenate kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000067">
        <property type="entry name" value="Pantothenate kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000001">
        <property type="entry name" value="Pantothenate kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1700.10">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035073">
        <property type="entry name" value="At2g17340_3_helix_bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-0944">Nitration</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="17">
        <location>
            <begin position="447"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="788"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU21386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="827" mass="92859" checksum="28A1A5FBD18C626E" modified="2017-10-25" version="1">MAEATNETFHPQSIKLPAAVEVFANLKNAQKFAIDIGLSLTKIAYYSTVRYRKALYEDAEDVATTTTENDSERDYQVFEGNRLHFVKFETRHIESCLDFVKANLVNVERFQGTSIQVTGGGAYKYKELIQEKLGTQVDKKDEICCLINGCNFLLKNIPGEAFEFERHANPEYKFQKASPNIFPYLLVNIGSGVSILKVESEQEFERVGGTATGGGTFWGLGSLLTNAKGFDELLQLAEIGDHRNVDMLVKDIYGGDYSSQGLAGDLIASSFGKAVNCNKSESGAKKFSEADIARSLLFLISNDIGQVASLYASMHNMNKVYFGGYFLRNHPLSMHTISYAIKYWTNGQVKPLFLRHEGYLGAIGAFIYGAKSESNKCSWLENYAGSSGFKDVIKSAELGIQVDQLEIDQAENAVSFCPLLIDPANYNPDTTDLAQDKEARDYWLECFEESVDKFITRAIHSQPQSPTAKDRANKLKEKYISRLHYLREQPFAYGTLTVRTLLDTIEHCMKEFDFPDPYLHQKKLENEQALKHFKSRLDEIDALEGNAKVEELIKGVLTGNIFDWGAQEVATLMETTEFSFKDAQEKIPERPWLEDGLNEWTTRLHEEEPHRCAAVFIDNSGVDVILGILPFVRDLLQRGTKVILCSNSMPALNDVTHPELVVILRDAAKICDVIKYALKEHRLMPMETAQAGPCLDLSRLNLDLCLAMIKHNVDLIVIEGMGRTLHTNLYARMKCECLKLAVVKNRWLAKRLGGDMYAVICKYERKAEKADLQNESFSMEQCACKNKRKNSLHQSTTNSTDDATSQALTSSNIENDSSDASTTNTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETL4</accession>
    <name>A0A232ETL4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002267">
        <property type="protein sequence ID" value="OXU21674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETL4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7024" checksum="8A8D2B33E388C95A" modified="2017-10-25" version="1">MSETMNEIIVHSDTCDLNAQIAKVCKSRLFVTKVVLICTVRLAYERSKCDKQGAKKDYFSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETP9</accession>
    <name>A0A232ETP9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002256">
        <property type="protein sequence ID" value="OXU21714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETP9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="313" mass="37085" checksum="FA2B4987F9D4B0EB" modified="2017-10-25" version="1">MVYYEYYDTEYCIPDEDSLQNNRQCKLTIRSSYKLLEIGTQESEDGEREFFVIRLTKNAVDREGEPNISFVDIDIDDVDCIAEQERYIRYLLQRNMYRTVYQNKSTHVWVKPGDIPMISTRNHRHCCHSSNMSYYNFNAIADKDILENSRQYQLTATSSFKILETGVHASSKNFVVRILRNVVYENGHSYVLYVNMSKHEFDQITREAGLISYLLQNQMNKTVFQSANVHVWTQSPTKNDPTPAMLCIRGSDERAYDRFTGDLDDDDSSYYSDSESTDSTEQDTDDYYYDNYYYDNYYDYFSDDYSSDDDYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETV3</accession>
    <name>A0A232ETV3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">28S ribosomal protein S14, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002218">
        <property type="protein sequence ID" value="OXU21783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETV3"/>
    <dbReference type="STRING" id="543379.A0A232ETV3"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU21783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18555" checksum="6AE27E8A7A20AC4C" modified="2017-10-25" version="1">MALFNSAKSVLSKLLCTGPTITQYGVKQDILRLYNLNHNYILCISLNHQLQQVRTKWTKKMTMRDMGRRAQVKQYAKDRLRYVAMKRNNILPTEIQELASEAFDFKNIPRTSSLRALTPRCVVTSRGYGTVIRWRLSRFIFRHLVDYNKMAGVQRAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU22</accession>
    <name>A0A232EU22_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002177">
        <property type="protein sequence ID" value="OXU21865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU22"/>
    <dbReference type="STRING" id="543379.A0A232EU22"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="177" mass="19583" checksum="700DF4609934D481" modified="2017-10-25" version="1">MCQVVDSLQLLVYFIPKTTPTRGLGWTRKAEVGDKMAAEVPEVAKNIFLLTSQVTKQNYYSSGSRSQQPRNLAHRTAPSSNQTQVVGMPSVGSTSGQPTSMYPHPNIAMQPSTIYVQNQVSGIHTNPHQQNVYSINNQMSIPILLNNIKILNQIPIGSVYSLNKKMESDPLQNQENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUT5</accession>
    <name>A0A232EUT5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_010751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002091">
        <property type="protein sequence ID" value="OXU22098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUT5"/>
    <dbReference type="STRING" id="543379.A0A232EUT5"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF335">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="454"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="616"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="749" mass="86287" checksum="E5BE9FA0154CEE57" modified="2017-10-25" version="1">MDEEEERRARMERMVEDTERMEMMAEEEQQRPRSRPRQLEAEEQPKQARARSPAVNRPEAEDSTRARAAASPPRKADTSEEIPPTKTSRRPRESSEGTELRRRMGSPEAAKTRASRHLSPSTTVPPSMTNVFINPSIDQEEEQQELQRTSSKKRVSSRQRHQNPSDEEEPPPPPPPIAHRSRRSPSQPVKKQIIPLSDDSLIEDVARAKRAYAHREPSDDYEYEDEEEEDEDEEYIRPRRKREATVRKRKTSVMHTDQEKEEIRKNVNQTSSWWSWIPFFGRRQKVEEMIEESEKEKKKKGKEKVDDEPPPKASKSKLEKNASTTAEPEKATIRDFFRSISDINGEFNEFCRQNPREVQILCELRNLCIVETVLTIIVCGLGAFAFRFTEGAFEQFYKCGVKRVKRDFLDSLWNFSHNMKEDDWKSMARRKLMDFEEQLHAAHEAGVQTYSGQKSWTFLNSMVYCLTVITTIGYGHISPSTTTGRALTIVYAIFGIPMFLIVLADFGKLFTRGIKFLWAFVRRLYYTGSCRKVRRTVQMQEMMKGVQMVYDLATFRRPSQMTPEELQEMQRQQQTVLSLDGNTQVQQQPESPSTPAMSTFEIDDEFNLPISVAITILVVYIFIGATVFNIFEDWTFFESFYFVFISMSTIGFGDFVPMEPLYMMLSIVYLIFGLALTSMCINVVQVMLADQFKHASQKIGATIGFHVSEEDGSLKPGPPEPVEIAEVHGAAEGTKEKVAPKAKQEDVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV74</accession>
    <name>A0A232EV74_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016878</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002052">
        <property type="protein sequence ID" value="OXU22235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV74"/>
    <dbReference type="STRING" id="543379.A0A232EV74"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU22235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="13718" checksum="9B39B4F4E8F9D341" modified="2017-10-25" version="1">MAPKASGKAVKKAGKAVKNITKGDKRKHKKKRKESYAIYIYKVLKQVHPDTGVSSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW18</accession>
    <name>A0A232EW18_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001923">
        <property type="protein sequence ID" value="OXU22554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW18"/>
    <dbReference type="STRING" id="543379.A0A232EW18"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="10693" checksum="028FBCF112673899" modified="2017-10-25" version="1" fragment="single">MSTTLIFAAGEHRGSGPAGSARGGSERGRVSGFGSGDHADSMDDPSSREDISEMVQQNISSKPKTSNINRSESYKERIHNKRQLREKRKTSDPNLSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWM3</accession>
    <name>A0A232EWM3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001841">
        <property type="protein sequence ID" value="OXU22746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWM3"/>
    <dbReference type="OrthoDB" id="7469116at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="11595" checksum="75B46D44DAC7497D" modified="2017-10-25" version="1" fragment="single">LNERNVRYSVAGDDQYRGAGGSSSGSPPASLLVVPQPLTVKPSHPSHLNPHLGGPHAHPPRKYQCKMCPQVSNRCTKILSVSVNTRAFPLPNATADPQPALSLSPKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWS9</accession>
    <name>A0A232EWS9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Presenilin</fullName>
            <ecNumber evidence="8">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A22A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01001825">
        <property type="protein sequence ID" value="OXU22798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWS9"/>
    <dbReference type="STRING" id="543379.A0A232EWS9"/>
    <dbReference type="OrthoDB" id="20287at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.100:FF:000001">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="499" mass="55033" checksum="57FE3E6CA536A0D4" modified="2017-10-25" version="1">MSESDYDCADEYTSLMDGHVAAETNRTASAPLATKRKKTGSKVASSIEMENGIPEVHIEDGSSRTRREHPDPVPPGNPVDHNDQDEVEEELKYGAVHVIKLFVPVSLCMLVVVATISSIGFYTTKGVYLVYTPFHEETNDSGTKAWQAVANSLILMAVVVFMTVILIVLYKYRFYKTIHAWLIISSLILLFLFTSLYCEEVLKAYNIPMDIITLAIGLWNFGVVGMVCIHWQGPLSLQQAYLIFIAALMALVFIKYLPEWTAWAVLAVISIWDLIAVLTPKGPLRILVETAQERNESIFPALIYSSTVMYAFTMNFTGYVAAATMANGDTAAGDSISSPARVQPQTQRSSVSSDTEEGGFTREWVETHADRSARRAQEVRENAQNSRGSAQVDGASQQANQQQMMMMQEERGVKLGLGDFIFYGVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISIAFGLIFYFATRVIVAPFADSLASEQIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYE4</accession>
    <name>A0A232EYE4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001629">
        <property type="protein sequence ID" value="OXU23381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYE4"/>
    <dbReference type="STRING" id="543379.A0A232EYE4"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF17">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="254" mass="29012" checksum="80124F87D885E91E" modified="2017-10-25" version="1">MEVKNDERSKSSIYLMVPFRKLCMVTVSIPLATLLFCFVTAYIYQQDDIHETHCRVYNVLPSISAITGVSPQRYLWRVSIALHIGPRLLIASVYYSFYHKILKSFEDVPKRLQGFRLLNLSYWLNIAEVGALCGVTYISNKENYAVHEKTFIVFMISSLTHMLVAVRLGRLVTPNAQSLQYKQALFTTSMISTVGLIIFFLKHRLLCHDLAFSWFSLCEYVIASANMAFHATVMLDFPVDQLVVGNGLHLLKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZE5</accession>
    <name>A0A232EZE5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_005959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001586">
        <property type="protein sequence ID" value="OXU23518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZE5"/>
    <dbReference type="STRING" id="543379.A0A232EZE5"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="12">
        <location>
            <begin position="145"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU23518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="441" mass="48280" checksum="9E3C665DEEE93913" modified="2017-10-25" version="1">MPIRKIKARQIFDSLGQPTVEVDLITDIGLLRSSVPCSSLFPGDNEAKEIRDDDEAAYNGRSVLKVVESINNVIAPEILKSKLEVNQQREIDLLMQSLDGTPDKSKLGANAMLGISVACCKAAAAKRGLPLYRYIAILSDSGANVRRLPVPVFCLMSGGRAAGNGLVYQEFLILPTGAETFAEALRMGTEIYRDLERKLAELQELKPPLTVADDGAFAPELEDDNEALTTLNEAIKSAGYDGKVKIALDVDASAFFREGMYDLEFKTDESDPENYLEPEALREQYTELFTQFPAIVSVEDPFDQEDWDSWSALASQAPTVQVVADLLTATNPERIEEAKEKQAANCLSIKLGQIGTVTEAIECVKAARAAGWSYLVSAGHGETEDTFIADFAVGVSAGQFKAGAPCRGERLAKYNQILRIEEELGQEARYAGEKFRELIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZT5</accession>
    <name>A0A232EZT5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pacifastin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the protease inhibitor I19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001501">
        <property type="protein sequence ID" value="OXU23780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZT5"/>
    <dbReference type="STRING" id="543379.A0A232EZT5"/>
    <dbReference type="OrthoDB" id="7655988at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008037">
        <property type="entry name" value="Pacifastin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036201">
        <property type="entry name" value="Pacifastin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05375">
        <property type="entry name" value="Pacifastin_I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57283">
        <property type="entry name" value="PMP inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51446">
        <property type="entry name" value="PACIFASTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511529" description="Pacifastin domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Pacifastin" evidence="9">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Pacifastin" evidence="9">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="site" description="Reactive bond" evidence="7">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="site" description="Reactive bond" evidence="7">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="281" mass="31637" checksum="8CAB121FDBAF51C0" modified="2017-10-25" version="1">MKSLFVVLVATAVASAHQVCTPGTYFKTECNTCVCANDGSASICTQKQCPPGLFNWDGSLKVPLDIIQQIIPDVSEIEIFESQLVAVGEVTYVQTCTPNSVFHINCNRCQCSKHVKKVCEPNQVFQNNCNTCACNKDSTAAACTLKKSPLLSCPKQKRMWLRCKFNVSSLFDQASADYIVDIVNRTYTSRNERFWNMYFTSTFFLLMLAIFNADDIEMQCKPKTRFKFYCNTCWCSEEGTTRICTKKYCPDNIFNKDGSLKTPPNVHQKLKIFPKGVGSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F095</accession>
    <name>A0A232F095_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001376">
        <property type="protein sequence ID" value="OXU24186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F095"/>
    <dbReference type="STRING" id="543379.A0A232F095"/>
    <dbReference type="OrthoDB" id="10064535at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="511" mass="60670" checksum="53644FE0FAB3E21F" modified="2017-10-25" version="1">MLKRMVLMNRCTLCAIPMQIPLVFVKNHRTVMSSYEGFQFKRPFQPNKILKKNNSKEPRNRVNVRVKDSHVSAVRLLLERFEVDMNELNTHKSIFVETTYTIERRIMLLQELGVPKITISCIVNFIRGMYLPVDRFKANFAIDPDFNIAQNLLSYTENPNINSQAIDHLNESMTMKQYYAICFAYYLKTELDLDEVQVKRISYKKYTPVLYNSFRLVKETLKIVRDMQFPVSLMIKNKYIFSLHPENASSVIDMIKSFNLPNKTLLRYPKLFYYDLDDLRTLLYYFKQYNITPQMIQSCYQIFHLSSAEFKRRVEHILSNPFTLVYQTHPRFLVLVRDYHIILPRIRYLQEKNLKFATIYTLTTFHNYLEILISKKKMNLLNIRSFLQSQFGSKGEELIEPIRRHACYAYAPLVQNYETLVYLKEVYPKEAIIKHIYAILYNKLDLQAAREVIMNDPEYSQWAPDKLLALCVYKIEEKCHFSGEAVLEPEKYAESVKEESSQDISKEMNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0G4</accession>
    <name>A0A232F0G4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase 2-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDK2AP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001420">
        <property type="protein sequence ID" value="OXU24040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0G4"/>
    <dbReference type="STRING" id="543379.A0A232F0G4"/>
    <dbReference type="OrthoDB" id="9628807at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017266">
        <property type="entry name" value="DOC_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607:SF3">
        <property type="entry name" value="CDK2-ASSOCIATED PROTEIN 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607">
        <property type="entry name" value="DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09806">
        <property type="entry name" value="CDK2AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10519" checksum="6AA158127EB46737" modified="2017-10-25" version="1">METQRKIAEPLLTIPKPKPQFLQQQPQLQTKISNGTGKSKYTELLQVIGEVGQHIRPSYAGHRGSAEKIRQGIIKARALVRECLIETERSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F246</accession>
    <name>A0A232F246_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methyltransferase-like protein 17, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001263">
        <property type="protein sequence ID" value="OXU24569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F246"/>
    <dbReference type="STRING" id="543379.A0A232F246"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="57919" checksum="52E11F15EE03B92C" modified="2017-10-25" version="1">MRASCVFQKLKLSSSLQVRWVTSKPQFKLKDEVENAIVEEKIKPRKHPGIIKNKLITLPDWIVQAMDERFDDADRTDIYKQRKIFQNYLFSRRLPLEKHELQEQYLFIENKILQNKINDQSTEEEIEEMRTVIQSQVKYKLKEHVFAWKPINYNKHRSLLYMIARSTAEYSVLHRIFEEIKIRDPHFDPHTMFDFGSGVGSVLWAANTHWKNINEYLGIDISNDMNDLSEKIMSYSPKKIKALLYRQYLPVSNLKHDIIVSAYSLMDLPDTKNRLDVISKLWRKTSKYLVIVEQGTNAGFKETRDYVKYMTTKYDVKSDYFTFAPCPHELSCPRYMERKTPCNFLAHYHGLRLVGPSSPQTELYSYVVFKKGERSENDNWHRLVRPTIIRSKHTRCQLCTSNGKLEQVVFTASKYGKPLYQCVRVSSWGDRLPADLINQDDQSNSTEEQKLNPTLSEDDTNCESVEDKVEDTSKKEKIIYSEAPAFTKTNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3Y1</accession>
    <name>A0A232F3Y1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001018">
        <property type="protein sequence ID" value="OXU25474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3Y1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="617" mass="69679" checksum="44752582FEEBE216" modified="2017-10-25" version="1">MSGSDSDSDSNEIKNGPFRCTCKCGVANCLDVSYTDCDDTESEESFSDDSLSQTSTDNKKTIFISIFNHKTQRNKNLISDTVEIKNYREQYQKLPLKNVNNIKKIWADVKVDMPLLGQIPLKCIDDELTEVKKGKYSHKKKLKKPTHLMQNKLSADSPANNSQQSVVADKSHKIGQPVVKQVHEKLPQAQINKKNTKDTKIKKANESILKGATKNTTSNENKNPKNEPKVSNKSTQSVKPHIIKDNLKFNTGKTVNSNSNALTSIQPIIETNSTNNISNTSNKKSNNQNNSAKVDTIKTPVKAIVENKIKKNEENKKKTIADSCLSKKESKEDMKIAKINLSTQSYTKSISKVKSENSNSDISNMKSSAEDKTVKVDNFVKSEAKMNTENRIEKTNLVELNAKSNTENKIVKDESINSNVESDVESQTLNNNLNKKLKLEVIEFRIPNSNKIIPSSNRNENENSANDKNLQSNKKLSKKQKKKMRQKEKNLEANVKDISTSNTRDLSISSSKSFDDKKSKNNSNKNVKEEATKPKKKEVNNTDKDKTKNKKLIEPEHSEQDTEEFEIEEMNSISNDNLDLLTDTKHMPTFIADIIKRKKKKTSQNKASNRNTNKKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4C0</accession>
    <name>A0A232F4C0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allatostatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000985">
        <property type="protein sequence ID" value="OXU25611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4C0"/>
    <dbReference type="STRING" id="543379.A0A232F4C0"/>
    <dbReference type="OrthoDB" id="10067964at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32829" checksum="80A431CE8E4BCD47" modified="2017-10-25" version="1" fragment="single">LANIIVAASSEQPRGRNNSSVEEEKKKKKKKKVIEQIVFPEKNERERGCLGRLLTAATATNRAKRSMSSSNLSGTAMSLTIFCVLSILGGTSVAMDEQPSASSSSGVSSSSSSSSHGPHFSQLVDPRDQIVGGKRAYTYRSEYKRLPIYQFGLGKRWVDDKRSQPFSFGLGKRTRPYSFGLGKRSSYSEDDGSRYGLGLSYLIQPSDLYEQLAQRDALENYLQQQQAIKRTGGFNFGLGKRDAEMNEGMMREDGLHEKVPVKHSRDKYLFGLGKRFYEPATMQDDEDEEMLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F516</accession>
    <name>A0A232F516_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000995">
        <property type="protein sequence ID" value="OXU25570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F516"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="463" mass="53676" checksum="15E00D2A568D65D3" modified="2017-10-25" version="1">MSQVMIKVINIYLIPNFFVSDLRNLTFYRILFYIGNYFVKFHRFVKFSHVMKGYCHDMLCSQNIRMIIFQNIFLTFKYFFAIFQRCIVVASQQKHQCDIREKVFDQTEVSVILRQQVSSVDRLAFVQYVLDLQKSIHSFTSNVVLEDQVVEYFGFLDFGAQAKRILVGYAPVQEQNQQFQLIDITRHQEQSRFVALLGTCGQKLALVQVQPHFEQVSVVPNLKLALVQVQPHFEQISVVPNLKLALVQVEPHLEQVSVVPNLKLALVQVQPHIEQVSVVPNLFFFPAYFHQSPTVACITSILWPLGCTRKRRGEHTELQSVIPVLELSWRLEKRTKPRIHLPSSFRNVDGRNTPEPTASPTSFQDRQNGNQSGTRNRFWYQSPQVQQGKKLQPDIRERLNQSLRRVRRRASAALDLGFRGRQLSSEICKQGPLGDVLAMRDTSPRRTIGNRRKMPVDNVPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5E1</accession>
    <name>A0A232F5E1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_014127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000965">
        <property type="protein sequence ID" value="OXU25698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5E1"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="94"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="24084" checksum="62AEFD01D2B7068A" modified="2017-10-25" version="1">MHHRHRFANQANHNRSLKTDYLPHRVYSESRRFVFHHRHHQQQQQHHRRHPKSAAQHRLAWTVLLLAAGLLVDAAKPDPPDIITTVGSQKLATASDCSKPVAFSGTHANIENARLILTETLLDKGVGYASNTGIFTTFCPGLYQFSFAGYGSSDLRLTLKRKLSKTETWQPVVSSGPSGGANIVLLRMALGDQVAVFVDSGKTDDSTTFSGYRIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5E3</accession>
    <name>A0A232F5E3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ecdysone-inducible protein E75</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_016429</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000921">
        <property type="protein sequence ID" value="OXU25895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F5E3"/>
    <dbReference type="OrthoDB" id="7634782at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018990">
        <property type="term" value="P:ecdysis, chitin-based cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007553">
        <property type="term" value="P:regulation of ecdysteroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035075">
        <property type="term" value="P:response to ecdysone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06940">
        <property type="entry name" value="NR_LBD_REV_ERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000029">
        <property type="entry name" value="Ecdysone-induced protein 75B, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF473">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 75B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="70"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="203"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="72411" checksum="90985023B70625C2" modified="2017-10-25" version="1">MSSTAAPQSRPSSVGPFTPRPVYCHYQTNSSPTVSPTGSPPISTTMPTMDSTVSSARPEPELNIEFDGTTVLCRVCGDKASGFHYGVHSCEGCKNREREKTKSSTSFPMGCLCECDLACSSSPALSSGSTGSGSSSDSDTGNLTDEGFGDSASSQGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDVAPVLARARETPNYTACPPTLACPLNPNPQPLTGQQELLQDFSKRFSPAIRGVVEFAKRIPGFSLLAQDDQVTLLKAGVFEVLLVRLACMFDAQTASMICLNGQVLKRESIHNSSNARFLMDSMFDFAERVNSLRLSDAELGLFCSVVVIAADRPGLRNTELVERMHNKLRSALQTVLAQNHPQHPDILRELLKKIPDLRTLNTLHSEKLLAFKMTEQQQQLQAQQQAQQQAQQQQQQHWPMDCDEPSGTEKPDKPASSSTSSAPTSVCSSPRSAEDKEVEDMPVLKRVLQAPPLYDTNSLMDEAYKPHKKFRALRQKDSAEAEPAXXXXXXXXXXRRATAAATSSGPSAVRLAVELRAAEVADVGHHDDDGGETATATAPAAVFPGLPGGVALELXXXXTSSTSTSPRPTSSGSAHLVLPSNMVELQVDIADSQQPLNLSKKSPSPSPRPLMPQGSTCKALSLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5X3</accession>
    <name>A0A232F5X3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000936">
        <property type="protein sequence ID" value="OXU25839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5X3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12338" checksum="DA604FA6E733EAA2" modified="2017-10-25" version="1">MFSVSHEQRNPRWQPTSRDRACLAIVAAAGTCGALFYSTGIFQLSNFKFDLSKCQCKSALSDTKQRDEKIGPMNRNRIQILNSFLEHRIERSREYHKTGIPHSTRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F837</accession>
    <name>A0A232F837_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 H</fullName>
            <ecNumber evidence="8">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">(E3-independent) E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_000895</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MAEA and WDR26, components of the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.24" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01000733">
        <property type="protein sequence ID" value="OXU26762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F837"/>
    <dbReference type="STRING" id="543379.A0A232F837"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000078">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="3 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU26762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="198" mass="22255" checksum="A996B194A9B68376" modified="2017-10-25" version="1">MKLENRIESKHEVTILGGLNEFSVKFYGPRGTPYEGGIWKVRVHLPEHYPFKSPSIGFMNKVYHPNIDEVSGTVCLDVINQAWTALYDLSNIFESFLPQLLTYPNPIDPLNGDAAAMYLHKPEEYKKKVAGTSLALVLFIRFVLDSILPRLVADYVRKYATEEALRDQENGGTGNGVSSDSESSMSDFSEDEAQDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F886</accession>
    <name>A0A232F886_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000754">
        <property type="protein sequence ID" value="OXU26663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F886"/>
    <dbReference type="STRING" id="543379.A0A232F886"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13380" checksum="E62F5AA926031ED9" modified="2017-10-25" version="1">MADEDVNGDSDEVQQEKSQKKTAKYDSGAADLEKVTDYAEEKEISSSEGFSSAMTIIGDRRNKEAAEKKAKEKELLKISINKEDVEIIMKEMEINRNLAEQTLREHRGEVVEALITLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8Z2</accession>
    <name>A0A232F8Z2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000698">
        <property type="protein sequence ID" value="OXU26929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8Z2"/>
    <dbReference type="STRING" id="543379.A0A232F8Z2"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF152">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="335"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="678" mass="76884" checksum="F7FD7BED9DDA6689" modified="2017-10-25" version="1">MVSSSESAKLELVPVKKLKPDGGSAREESVQFVEQFVKDVVDFSSQYGSNISISYTAYNIAGNPSKFPDYGDFPQAFVMRTYGRWWDNAPSKSLDYMPQNNGPIISHDYIDLEYHKEVYPVRVSIYETYNPGSVVAIWARDDTGQWLLLWDGPPQVVPHKPRIFSPPLQLCNFKTKMLRLEFNHSLLEYYTALDAVLLIGTSELIIPNVGFQTRSLSSLLKELGGTGYSNEDCYNLTPDYLKANQDLKKLKSTLHKHCVLYKSKSVEKVPKGRLAAKLGWHCHYIPPIEEAFNSIQKFLQEDFPKLIKDINISSSSIASAESENEAQINNVNNTCGSFSVLPDETILKIFKHLDLKSLSRCSQVNRHFNNIAQDALLYTSLNLKPYWHCVDAAVLNSYVSKCQYLQRLDLSWCGNYDTISSENFVAFLQSSGATLTHLRLNCCRFVNDTVIEEISRICKNLKELCLRNCTAISGDGFTPLENLENLERLELYRTSIETDDLCSILRKNSNIRHLNLASMQDRLNMDDVAAEIAVSCTKVESLDFWKAQALTVQGIRAIAHCTHLKEVDLGWCSGIGAPGDSLRLLFSSCRNLEKVFLTSFRGLTDRDLEPLLLCKNLKQLDLLGARYISGQFCMRLLYCLQLDMIDLSFCDEISDDAILEMRSHFPRVSIKRIFQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9Q8</accession>
    <name>A0A232F9Q8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000677">
        <property type="protein sequence ID" value="OXU27047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9Q8"/>
    <dbReference type="OrthoDB" id="8183954at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895596" evidence="1">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="14421" checksum="AD8D01BA857ECCE6" modified="2017-10-25" version="1">MTSTKRIVILAAGVCLVLALVQPSTASDQKYSGQYDDLDVEAILKNDEERERYYACFMDTGPCHTEAAVFFKSKAPEAVVTSCKYCTDKQIEMFEKIVSWFVDNKPKEWNALIEKTINDARAKGIPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAA1</accession>
    <name>A0A232FAA1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentraxin (PTX) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_001405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000583">
        <property type="protein sequence ID" value="OXU27552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAA1"/>
    <dbReference type="STRING" id="543379.A0A232FAA1"/>
    <dbReference type="OrthoDB" id="8793160at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF125">
        <property type="entry name" value="B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pentraxin (PTX)" evidence="7">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="294" mass="32838" checksum="DB115B3009A30974" modified="2017-10-25" version="1" fragment="single">MMSVDGHNLYRLNYPLQLNKWYHSCQSWNGHTGEWQIWINDERVGRGFNNRLVGHIIKGGGVAISGQEQGQLDQGLLKSDSLSTVTIGMRGELTMLQLYHVALTAGKAHRDHKHHHAHHFEHNSDNHLLSSTTAQVPVTGPPLPINPYITGGQINHQVKLNPGAHIQIIQNGVTLRHLNTPSAVKVLQPLSLAIQPALATTEHSLTSSQPKLSYNFVKTLIDIGGSNIPSKSNVPVSEYSFVNRQYRHTFATKPVLFSEQIVTYPQPESQLNGRVHEDINQLDKLVELKKITKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB06</accession>
    <name>A0A232FB06_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly factor 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hcp beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000558">
        <property type="protein sequence ID" value="OXU27670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB06"/>
    <dbReference type="STRING" id="543379.A0A232FB06"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040239">
        <property type="entry name" value="HcpB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13891:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26231" checksum="7AA237ADC7DF38E2" modified="2017-10-25" version="1">MAYDLKSEEDVKLYLKNLYTEYQFGCYGEKNPEVCHLLGDYHEALKKDFKGAADIYQKNCDNFNFGRSCAKFGGYKLIGKGCKKDMNDAFTYMKKGCEFNDEIGCTNAGILAVSSPEIQSNDRAKVINDGLKMLDKSCREYKTDKACFFLAGIYMSGIEGVVQKNLAEAYKLSLIACEHNNPYACANVSQMHARGEGAQKNEELAQTFKKRALELERELKSTQSGIKFGQGIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBE6</accession>
    <name>A0A232FBE6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_014527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000561">
        <property type="protein sequence ID" value="OXU27657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBE6"/>
    <dbReference type="STRING" id="543379.A0A232FBE6"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000003">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="9">
        <location>
            <begin position="726"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="10">
        <location>
            <begin position="845"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="956" mass="106038" checksum="950ECD1B64ED2DD2" modified="2017-10-25" version="1">MTDSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKYMSTYHLCLVVVSYFMFGLVKCMSLRFVSLKDQTSDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLYDINAGLVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINESSPSGQPLVEMNAQTINKLLTALNECTEWGQVFILDSLANYSPKDDREAQSICERITPRLAHANAAVVLSAVKVLMKLMEMLQSESDFVGTLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLSELKEYATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMIWIIGEYAERIDNADELLESFLEGFHDENTQVQLQLLTAIVKLFLKRPTDTQELVQQVLSLATQDSDNPDLRDRGFIYWRLLSTDPAAAKEVVLAEKPLISEETDLLEPTLLDELICHISSLASVYHKPPTAFVEGRAAGTRKSLPARSNSNDDPASRSQPQAQVIPAQDSLIGDLLSMDIGGPSLVTPTPPPSTGLGLDLLSSGLDGILGGPETTAPPAVSQTTTGLLGDIFGFTQGTTSYVAPKVNWLPAEKGKGFDIWGTFSRKNGQINMDMTFTNKAMQPMGGFAIQLNKNSFGLAPAVPLQVPAPLNPGQSIEASVVLSTVGAVQRMEPLNNLQVAIKNNIDVFYFACIVPMNVYFTEDGQLDKRVFLSTWKDIPAQNEVQYTLSGIMLTTDQVVSKMQQNNVFTIAKRNVEGQDMLYQSLKLTNNVWVLVELKIQPGNPDILLSLKSRTVEVASAIFQAYNAILYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBI6</accession>
    <name>A0A232FBI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000536">
        <property type="protein sequence ID" value="OXU27813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBI6"/>
    <dbReference type="STRING" id="543379.A0A232FBI6"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012714634" description="Beta-glucosidase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="106245" checksum="BA0E59E5DDA7CDCB" modified="2017-10-25" version="1">MTGAALLRCLLLASLALTLVAAKKELKLLNVLSANKFYVPDYDYPTAELQVPSNLTYKYFIENALDVPNSVKMHLYNLGVHLRNMYGDYLGSIYVDEIIRMQTTEYPASIIAGELINAGLWPPVEPQIWKDDLPWQPVPFVYTPAIEDTVLLGSLCSNFEYETHKILKNHLNLTTQQTEVIDYIRTKGHVNVKNPIHVSLLYLVLQNSIEINKRHPDWVKQIFPGDALLNVTLTAYELLSKTTVQKRLNGGSLLKHIIKESKERIKGTLHHSRKINVFSGDDRNLAGVLSILNISMFDLPSPGAALIFELFEEDGNHFFKINYYTGSSNDTIPYKLEGCDLFCPVENFTDLVADYLPENELSLCGSLVYKPPGMDDDSEPDGASTLSASLTFLSVFVVLTFNMLSDLVGLFYVADYSSDSLISMNINIKEKNSILESYEFATEAMKVTHAVAQNRFPNMFLFGAASSAYQIEGAYNSSEKGMNVWDYWTHTNPDLILDKSNADDACKSFYKYPDDIALLKNLGANAYRISLSWSRILPDGMSNFVSLEGVRYYNDLINTMILSGITPVVTIHQGDIPMKLQMMGGWTNPNMTEYFKGFARVAYSYFGDRVKYWITINDPWTLCNMQFGDAMRPVYSDSGVGNYLCGHHVLIAHAKAYRLYREEFQWLQNGKVGISIGTNWFEPADSTSLDDLEASEISYQFANYWFLNPLLGEKGDYPDIMREQITVDSQLQFFKQSRLPVFTDEEIQLVKFSLDFLGIGFFTTYEVKAKPIDLDSFYEYDSVLSKPSLESDMESIWLVYDEVQGAFDIKNTPDNFRKLLQKINEDYILPPVYITANGYADLGEIVDYDRAKYHYDHINAMFASMGNGVDIRGYFAWSLMDSFEWQDGYRKRFGLYGVDFGDDDRPRVEKVSVGVLKNIFETKVIPDEMNLALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCC3</accession>
    <name>A0A232FCC3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_013361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000427">
        <property type="protein sequence ID" value="OXU28481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCC3"/>
    <dbReference type="STRING" id="543379.A0A232FCC3"/>
    <dbReference type="OrthoDB" id="6110560at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23592">
        <property type="entry name" value="TFP_LU_ECD_Crok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021305264" evidence="10">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="154" mass="17627" checksum="6376F21AE9D94B4F" modified="2017-10-25" version="1">MGCKKVLFLQIVVFVLLACFVERGVSIKCWACRSDSDPKCADPFDNSTVPITDCSQEKELDHLPGVKPTMCRKIRQKVNGEWRYFRSCAYMGEPGIRGDERFCLMRTGTYNIFMEYCTCNSKDGCNSAPGLHHNIFLRYAGLTAIFIITWFLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCH8</accession>
    <name>A0A232FCH8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="13">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EIF6</name>
        <name evidence="17" type="ORF">TSAR_002154</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
            <location evidence="13">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="13">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000447">
        <property type="protein sequence ID" value="OXU28322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCH8"/>
    <dbReference type="STRING" id="543379.A0A232FCH8"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06902">
        <property type="entry name" value="lectin_ERGIC-53_ERGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000028">
        <property type="entry name" value="Blast:Protein ERGIC-53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="16">
        <location>
            <begin position="251"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU28322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="726" mass="81308" checksum="18EC05E969DFEBC0" modified="2017-10-25" version="1">MAVRVQFENNNEIGVFSKLTNSYCLVAIGGSENFYSVFEAELAETIPVIHTSVAGCRIIGRLCVGNKNGLLIPNTATDTELQQIRNSLPDNVKVQRVEERLSALGNVIACNDYVALVHPDLDRETEEILADTLNVEVFRQTVASNVLVGSYSVLSNQGGLVHPKTSIQDQDELSSLLQVPLVAGTINRGSEVIAAGMVVNDWISFCGMDTTSTEISVIENVFKLNESSASAITSVMRASLIESVSTESPHRKFEYKYSFKPPYLAQKDGSVPFWEYGGNAIASSENVRIAPSLRSQKGAIWTKSPVNFEWWEIDLVFRITGRGRIGADGLAFWYTSSKGAYNGTVFGSSDQWNGLGIFFDSFDNDNKHNNPYIMAVLNDGTKVFDHANDGGSQILAGCLRDFRNKPFATRAKIEYYKNTLTLLFHGGMTNSEHDYEVCFRVENVFLPKNGFFGISAATGGLADDHDVLHILTTSLHPPGQMVTDGRKVSIEEENKLSKEYEDYAKKLEQQREEYRKEHPEERHEKDEFEEWFESDNQRELRQIFSGQTQTYDAIRTLSGKLDEIVGRQERMLSLISQIQLGGVQTGNVQPGQAPQLIDTIRRQEVDILLSTQNNILNTAHEIKSFITDVQSKADVILNNQARNPTAQVQPLNYDYQSFTAEIRDGLNVLKRDISQTNNKLNNVNVDCPNACLSTTMFLVFVVIQMIILMGYNMYRDNKEAQAKKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCY3</accession>
    <name>A0A232FCY3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000450">
        <property type="protein sequence ID" value="OXU28309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCY3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="6079" checksum="8852948A58718E45" modified="2017-10-25" version="1">MTILKEYKSILTKISFKNRRHRIFTKSCVYIREVFIGYARQIVQTIFKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDF7</accession>
    <name>A0A232FDF7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000422">
        <property type="protein sequence ID" value="OXU28508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDF7"/>
    <dbReference type="STRING" id="543379.A0A232FDF7"/>
    <dbReference type="OrthoDB" id="6623978at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="690" mass="79835" checksum="36BE893B8855E2E7" modified="2017-10-25" version="1" fragment="single">MDSIDESYFKTKYYQYKIRIKKWESNFINKYGRKPNKNDIKVADSTIREAYKIYWEFKIKTLENGSQEATTTYDNMKESTPVENSHFDLVLSKENQVYHRTELSPILNSIDPENTFSSNIYTSDVESYTPFFENKSNIKQAWDHHLNAEKNNCKQNESKFASNSSFQLSQERFKSLNFSKRNPRKLAIHSKLDDNTENSNKNFKEINLYSKNSDESIKTDTFKIAEWTKPNLKIISLKSNVTSKSSNTLQQLILRSSNDSPTNSRLLSKSWLDRCTEPSIDKTLATKVEEPKEEDSCMLYSSTNSDDDYVFNSDSKDHSNKRVRNHNNLFGDEYVQNVKKICCENNLCSSNDMKNLGKKLHDSHEHNKFITDSYNFIKVTDYTSDTSIIKSNNKVNENITFNDSQYTSENSSTVSMTEIIGSNQFQFDRKSRIDSKKLLNINNTNSKEYSDTFPQMPITDISEVIKPSIILTKSNHMIEDALVRNNSAKELNTNFLRINLKKKVFVRGKKSFNFSTYKKTQWKKKKEKADINAGNLDFLDSIDKNNTFLCFKCGKMGHLARRCKNSKDSGLLAIDDHEEMPDISQLRDVKDTTKLTGTTENSRNMCKDLMSPITPSIENLITRETGKIEKEFETSKKSMYDKIESLTIVKENLEMLDDYEVPEACKEEKIISRNQGISPLYSLDRDGSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDQ5</accession>
    <name>A0A232FDQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000412">
        <property type="protein sequence ID" value="OXU28589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDQ5"/>
    <dbReference type="STRING" id="543379.A0A232FDQ5"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="230" mass="26212" checksum="AC3A3247CFEC6306" modified="2017-10-25" version="1">MATTRALVYFIGRRHLMPCSVPITTIKANSYVPLCVPQAFYADQKSITKSEQPESGGQVQVGFAEVVKENTKSAWYMSVIVAGIGVTAVMFYAIFRELFSKKSPNSVYSLALDRLMNDPKVTDALGSPIKAYGEETRRGRRGHVSHTSYEKNGVQHMRMKFYIQGQRKQGTVYLEVREDANGDWFYRYLFVQLKDMARSVIVLEDNREIENNVYTSPEEMHEMVPPGFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE58</accession>
    <name>A0A232FE58_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000390">
        <property type="protein sequence ID" value="OXU28719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE58"/>
    <dbReference type="STRING" id="543379.A0A232FE58"/>
    <dbReference type="OrthoDB" id="419508at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="605" mass="67260" checksum="D0BB54D5F2339EFF" modified="2017-10-25" version="1">MLKVVGASWLQTRISTYILVAVALLGIGAVILGEFGRVENDGTYSATVWWKRISGYRIDFWGQGNDLKSLPLGAARAYYKTGILQTGWSTLEIETSPDYPDDVQAYAAGLLEGSLTWQLIHHHWYNTVRAACAPRASLCRKMRRYLRENAANARENAALLRYEDPYWHMVHLYYVQLDGLAEGWRFAVQRSRQDVNIDPEDFLWLAMASDLPDLERANNGSDHHIASDGMIVLKAIEREHFEPLMALAHNTAAPYSRMLRLMKRYKFSYRVSPEIDSEPVPGHSIVMTSYPGALSSQDESYMVVGENRELIVAGTPLIIDNHSLWSRLQTKDRVMSAGRIMAANRLATSGLSWSRLLDRQNSGTSNRQWISIEPRTGVVSLIEQIPGFTQHVDHTNEFRSKGYLGCTGAPYSSTIRELLGGERDESVARAEQLALLQANITSVEGLKALMRGEIRALSDNNKDEDSDEPLESENTEQSPSNPTITKSNDDNTSSSPLLSALTSTMSSSTLLSSSSSSSSSSLSSTEQLLAYRGDLASVPRPLGVIDSKLFLFDLDGLETFEARAGPARRIEAPAFDWTHSFPNSSHLGQPEIFSFDSLAPAWVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEA3</accession>
    <name>A0A232FEA3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Venom acid phosphatase Acph-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000350">
        <property type="protein sequence ID" value="OXU28992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEA3"/>
    <dbReference type="STRING" id="543379.A0A232FEA3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="107587" checksum="2C6870C634DB1D66" modified="2017-10-25" version="1">MALEGDLKLELVQVLFRHGARTNSESETRMAMSQYVDPSLHETFGYEQLTNVGKAQAYNLGRILRDHYNNFLSPLYRSDDIYAISSDYDRTKMSLQLVLAGLYPPTPEQTWNENLRWQPIPTHHVPQQADILFKGFDIHKYRSHILPFIKSPEYKEVEKTLKTLNDFFQSKGVDSVERFGFIGVIGVFNILSSHKASKGKLPDWYTDDLYENLRETVSLYFDLLSSTPELCKWQIGPLVRRFFDNVDVKGECTNPRKIYLYSGHELNIAAFTRAHGIKEFRYPNFSSAVILEKLRDSQNRLYVRMLASTGNDDNFRPLKLGNYKEYCPIEEYMKIVKDVIPSDEEIDSIYEGIPNDLKTLHLSDSSFKPKKSSSTSVTIHAARTVYKAEALMVMPQDIDPSLHETFSYEQLTNTQAYNLGRKLRDSYDKFWVHYISRTTSTSTAVITTCAAHDCRSPQIRRRREIFRRNTPVQRSSESNTGIRRFFPKLRNQLAAEIQIYWYPCNIQCLSILHTLIECFGTLPLHMLAWTGDDDNFLPLKLGNYKEYCPIEEYLKIVEYVIPSEEEMNSFYEGIPSHLKTSSFYTRTNAKSEVEMVKPQYIDSSLHETFGYEQLTNVGRAQAYNLGRKLRDRYDNFLGPLYKPDDVYAYSSYNDRTKMSLQLVLAGLYPPTAEQIWNENLRWQPIPTYYVPQKADVLLKANEMHKFKSLLSALEKTPRYKEVEKTCMRLNDFMLSKGVDALERYGILGNIRVYNILYSHKTSKGKLPDWYTDDLLEEFKKDIVLYFNITCSTRELCKWQIGPLVRRFLDNMNVKAETPNPRKIYLYGGHELNIVPYVIAHGIQEFRYPDFSSAVILEKLRDSQNRLYVRMLEWTGNNDTFLTLKLGNGKEYCPIEEYTEIIKDVVPSDAEINSMYDDIPNGLNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEI3</accession>
    <name>A0A232FEI3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_015793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000354">
        <property type="protein sequence ID" value="OXU28963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEI3"/>
    <dbReference type="STRING" id="543379.A0A232FEI3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="375" mass="42858" checksum="25964DD34A059DF0" modified="2017-10-25" version="1">MDSELDQILSECLSEDVPIQCINYKGLFVPDTYPVIADSVENFEVRDDDIWVCSFPKTGTTTTGWVSIRNPMDRQFPDIFAKSVENAASLPSPRFLKTHMPYHLLPRQLRTRDKQCKIIYITRNPKDTCVSYYHHYKMLEAYCSTFENFCKLFLGDKVYYAPFWDHVIGFWSRKEDKNILLLKYEDMKADLPSVIRKTANFLGKNLSDEKVKTLEEHLSFHKMKDNPSVNLGLAVHTINTKKIFGQNFIAEVTDRHVDKAETRIESAIIEFPCTPIPKALVIAPSDGGTVETECGLLQLIAAKTRTTRGREDHYTPQPSPRLSCASYRAGVLHCTHNATSPFSLSIYSAAPVKFFKKSIRQGNKRKSREMLVNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF92</accession>
    <name>A0A232FF92_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000298">
        <property type="protein sequence ID" value="OXU29372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF92"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="122" mass="14043" checksum="2702CAE11D69A1DD" modified="2017-10-25" version="1">MNYTFVDDYFDDVTVADVELLRELMLRNDSKDEKAIDLEKKFTCAVACVIDASISKKDVRISTYQLLKNIIEKEINVSREEIKSDLMNTLDTCHQQDEGDNCKLLECVKVLIPPFKALLFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFG7</accession>
    <name>A0A232FFG7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000342">
        <property type="protein sequence ID" value="OXU29057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFG7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="238" mass="26914" checksum="2973725061C52026" modified="2017-10-25" version="1">MSDTVANEDHNFMVLGNRKMVLVSPPRIQGEGSYYVQCESIALRFRSSYCPDPLLGAGITDFYFLHKSTLKLNLKKIGKIAPIAQRTLNGEKMNWTTSTNLLRLSPIYRYGGFLSFQSTPSNASKGYYCSYDVIVKMKVLQRLNSRFDVVKDIRPNGGNFFFMTQGYISYCNFRENTICMLLNTDLQVTATIEAPKLDIPERDSKEAYFVHIIINPFACSNQSIVKVPSQLPTSQVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFK9</accession>
    <name>A0A232FFK9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000339">
        <property type="protein sequence ID" value="OXU29087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFK9"/>
    <dbReference type="OrthoDB" id="10457353at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012805261" evidence="1">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="14583" checksum="23BE099876CC6540" modified="2017-10-25" version="1">MAITISSELSWAFIITCVTTTILVQARDPKSEVEAVPGIIYPSVPNQICMLRKGYECRWTIEKSCSCNLTQTRPLCRFFMILYFQANFGDFVHSQKAEKRSEGSCDGNARMPDRRSLHSNVVRPVIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFQ0</accession>
    <name>A0A232FFQ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000335">
        <property type="protein sequence ID" value="OXU29127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFQ0"/>
    <dbReference type="STRING" id="543379.A0A232FFQ0"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19007">
        <property type="entry name" value="LGIC_ECD_GABAR_GRD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000065">
        <property type="entry name" value="GABA-gated ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022265261" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="66"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="204"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="305"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU29127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="68980" checksum="C786DBD47FE76161" modified="2017-10-25" version="1">MELLRCVLLASLLVPLSLCRNRSSSAGSVGSEFVPNPTSDVTGPLAIGRVARGTVNDIVSRNITMVLENLLMNYENSQLPTHGKGTPTVVKTNIYIRSMGPISELDMDYSMDCYFRQYWRDSRLSFLGPIKSLSLSIKMLERIWRPDTYFYNGKHSYVHTITVPNKLLRITQEGDILYSMRKKKRQNSPPVVLAMLSSPFFKRNVSMTRRLTIKAKCTMDLRNFPMDRQSCPLILGSYAYTSGQLVYEWQDNSSVNFVPGMALSQFDLMGYPYRNLTFVRREGEFSVLQVSFNLQRHTGYFLIQVYVPCVLIVVLSWVSFWIHREATSDRVGLGITTVLTLSTISLDSRKDLPKVKYATALDWFLLMSFGYCIATLLEFAGVHYFTKVGSGEFPLQEEFMEDDEAATTDAEWEDIGREVLPGTDSDKDDGGFCTTTAATACVHSELSGAGLTSATATTTTTTNRRRGSSLFCALYNNSNYVRSQDQVYSLSPDPRRSMTITVSSKPSTMERQTQTELWLPKWRQFLYCLMGDMAFRKRRQREAADGCRKHGERIERYINSVSHIDRAARIVFPASFTLLIVCYWMVYVTYQEEFKWQDPPMGSQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFS0</accession>
    <name>A0A232FFS0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein DIS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_002199</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000294">
        <property type="protein sequence ID" value="OXU29403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFS0"/>
    <dbReference type="STRING" id="543379.A0A232FFS0"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000125">
        <property type="entry name" value="exosome complex exonuclease RRP44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000010">
        <property type="entry name" value="Rrp44p homologue, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="18">
        <location>
            <begin position="64"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="19">
        <location>
            <begin position="581"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1054"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1095"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU29403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1105" mass="125696" checksum="CC11CB9298037729" modified="2017-10-25" version="1">MLTSKTFYRKTKGGNIYKVVREHYLRDDIWCGSEACERCGRRNKDILLDDENPGAKSSLFSQPHYLVFDTNIILNQINILEENILCNVIIPQTVLEEVRHRSSNVYKKLKEIIGDPSRKFYVFVNEHHKDTYIERKPGEIVNDRNDRAIRTVAKWYNSHLSAQKISIKAILLTDDEDNKNKAEEAGIPVATMKDYVSSLENAGFLIDKLARKDYVLDGEGREPLFPCHLSPAQLHEGIKNGKFLQGTFLASRENFLEGSVNCESIEKFVLVQGREGLNRAVDGDTVAIELLPEDQWSAPSDIILQDETEDDPGDVLDDEKILTENKTVAPAEKTPTGRIVGIIRRKWRQYCGILQRSALKENTRHLFVPAERKIPKVRIETRQAETLSKQRIIVAIDSWPRNSRYPLGHFVRALGEIGDKDTENEVLLLEHDVPHSRFSDEVLSFLPKLPWVITESFIRLLLIQEKHSNHLASGRLTITVRRCARSRTSRITRESGQMKFQRRQLIVQDTFICIIVYVNRETKREFTVNGTTLFGSIIGQGGGGGICDSKEKADDVSGTNSPELLAFPERRTLALPDVAQRRDLRHIDVCSVDPPGCTDIDDALHCRDLANGNLEVGVHIADVSHFIRPGTALDKEAALRATTVYLVDKRIDMVPELLSSNLCSLRGNEERFAFSCVWEIDHDANIISTDYFKSIILSRAAMTYEEAQLKIDDKTQNDAVAKSLRNLNMLAKKLKKRRLENGALVLASPEIRFQVDSETHDPIDVQAKQMRETNSMVEEFMLLANISVAKKILEEFPECAMLRRHPEPPQVNFDPLIKAGRHQGFEINTSSGKELAKSLEAAQKEDNPYFNTMLKILATRCMMQAVYFTSGMVQETEFFHYGLACPIYTHFTSPIRRYADVIVHRLLAVCVGADATYPDLLDKKKSHALCHNLNYRNRMAQYAGRASVALNTHLFFRNKVQEEEGYILFVRKNALQILIPKFGLEGTLYLSKKGETSPVTFVYDEEEHTQRCGDIIFRSFDQVVVQLSLDRSNVQHEKLVFKLVKPMIPGFSIPSSSEGTAADKPAEEPMELSEEIPQKRKDEQEVEPEEAPTTKKGRKKKRRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGX3</accession>
    <name>A0A232FGX3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="3 13">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_011718</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="3 13"/>
    <dbReference type="EMBL" id="NNAY01000253">
        <property type="protein sequence ID" value="OXU29689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGX3"/>
    <dbReference type="STRING" id="543379.A0A232FGX3"/>
    <dbReference type="OrthoDB" id="545675at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000290">
        <property type="entry name" value="Protein-tyrosine sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU29689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="395" mass="44593" checksum="97892C423DDB2F38" modified="2017-10-25" version="1">MLDYPTKTSSSSNSSSMSFLFSRGPPRRGPILCIVALLFLLVLYQLGIICSAPKEPTAVMVAKEKYVVGPNDQKVYPYDRNMPLIFIGGVPRSGTTLMRAMMDAHPEVRCGQETRIIPRILQMRSHWLKSERESVRLEEAGVSKEVMDSAIAAFCLEVIARHGEPAPRLCNKDPLTLKMGSYVLDLFPNAKFIFMIRDGRATVHSIISRKVTITGFDLTSYRQCMIKWNQAITMMYKQCKDVGPERCLMVPYEQLVLHPREWMQKILLYLDVPWNESVLHHEEFINKPGGVPLSKVERSSDQVIKPVNLEALTKWVGNIPEDVVRDMAEIAPMLSVLNYDPYANPPNYGAPDKVVSDNTRKVLTNGQVWEEMARELELEKTSTHSSDSNSNGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH90</accession>
    <name>A0A232FH90_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000218">
        <property type="protein sequence ID" value="OXU29933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH90"/>
    <dbReference type="STRING" id="543379.A0A232FH90"/>
    <dbReference type="OrthoDB" id="10034606at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38779" checksum="D7001A464A59960A" modified="2017-10-25" version="1">MSYLSWNDWCQIIRSLIQYFADGVTLEEFAATMSSLGDLTVPYRSFNFQTLEDMLHKIPGLKLVYTNGRLVITAVMSENMCRHDRLHTTPHYVPLLRRNRITPPANNRPEQQPESNNPRRFRVAGNSYSSLFATVRARRKLNLLSPTRMAPSLQINRTISFYQRLRESTLSIPNELTPTPIILEQQRLISEANMDDPRLRLFNYTHARGLPEPVYGQIFVNNDDNVYASAEVDKLKYHSYPHEAKTIEEAEKVAAKKALSLLTIEETNPQVTTEDSSLILGRVLEIVESYPNGIFKSYVEEIYGKKYIEALPKNWLEIIEHEAIIVIGGNNEPKLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHY0</accession>
    <name>A0A232FHY0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ITPR-interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_015883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000169">
        <property type="protein sequence ID" value="OXU30354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHY0"/>
    <dbReference type="OrthoDB" id="6088188at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029325">
        <property type="entry name" value="ITPR-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043444">
        <property type="entry name" value="TESPA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469:SF15">
        <property type="entry name" value="ITPR-INTERACTING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469">
        <property type="entry name" value="SPERM SPECIFIC ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14722">
        <property type="entry name" value="KRAP_IP3R_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01257">
        <property type="entry name" value="KRAP_IP3R_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ITPR-interacting" evidence="3">
        <location>
            <begin position="87"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="577" mass="64876" checksum="2AD0395B29B021F9" modified="2017-10-25" version="1">MRRRTSPVQQWVDSLPSPAKSTASSLGSIIRQQSVSVDSESASIPECTVEQAYSEKENFISHSNMTVSTPITVPSSPAITYHGRNVSRLARDPSFQSDSSHCSSVESLLELRRADPEAVLLSLGFGGCAGSPQENGPLSRIPKRFLQPSRLKGIAINDFVRHQQEANESLDSTSLGYRGLTGRFLFPHPAPSRWIFYRTKRGVFGGRLKFIVFFRSDVSTGSPYVAPSEIVQKIMQRLREHESHELDAYASYNNNAEPYMLPQQQEGRLSVLSPDNRQFLERPRSKSPDMRNKRMIIGQRSFAFGRDGDLIEINPRSTQSSVESDDVFVYLDDLSPDTTSTMNQLGPTVYSGNFETSNYLKEPNNSFLHNHNKPRLIDLRSNPSKENRDSIETVIPVNINNNYVSTATINVATDKNHNESSEAASPRRASEGSNAKSSLQDQEEGRRHSDTVMHSMKKSDDELCRKRNLRRQAKIRDEDTVAEVEEDVSSRATSLRLSDESPRCSHCGKPERSHDDGEEAGVSCCYKGTSQNCWREMEKVLQKNKKLEDVVNKSRREMAEIRDMLSSVLSVRMEPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI16</accession>
    <name>A0A232FI16_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000172">
        <property type="protein sequence ID" value="OXU30322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI16"/>
    <dbReference type="OrthoDB" id="6341359at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="392" mass="42914" checksum="D043F7852904F639" modified="2017-10-25" version="1">MIVNDSAECSLCTLGPPPDMILRLPPPPIPTFLVHSSDYYPGVGASDGLPFFEHFNNSPCKHSCEWRAEGVQYVEMPQQGTVFDDTWLLVLISSCIGVIFIGIVLAALLIKCKFNRSNKNSTLSTSTASSGMQTTTTSGVGPCVNTKSLVRLQNEAVLYPCGQQDSLQDSRVMWAKLTPRGTTRHYLEEHTYETIGNVCNGQLPLPPPPPQPPAYVSTAGMTLAAAHHKRSYSESPTEHVNLKAIPTIYLSYFSDTYTEPPAPSPIMSRPKDEKAFDNTAFVDYEEPLSMRNEYYQLEDVLEPCDPIFSVQGLYGMPIRGGGVGNGGNCVSVGGTLRPRVSSPTRIEHPNLPPLNLQPLRKHPSRKNSLNQHAADCTLLRGSMTSSTYIPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI51</accession>
    <name>A0A232FI51_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ubiquitin-related modifier</fullName>
            <shortName evidence="6">SUMO</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ubiquitin family. SUMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000179">
        <property type="protein sequence ID" value="OXU30263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI51"/>
    <dbReference type="STRING" id="543379.A0A232FI51"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd16114">
        <property type="entry name" value="Ubl_SUMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000280">
        <property type="entry name" value="Small ubiquitin-related modifier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046332">
        <property type="entry name" value="SUMO1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU30263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11711" checksum="C3CAEF94DB6CD0D2" modified="2017-10-25" version="1">MGDNQEQKPDSGPGDVNSEYIKLKVVGNDSNEIHFRVKMTTQMGKLKKSYSDRVGVPMTSLRFLFDGKRINDDETPKQLEMENDDVIEVYQEQTGGHSWWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI70</accession>
    <name>A0A232FI70_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000165">
        <property type="protein sequence ID" value="OXU30385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI70"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11206" checksum="508604FCB9264E4C" modified="2017-10-25" version="1">MRFIGAKYANSSGCTEASAIANSKPTMRREKKLEKDQEGKRSCDAKQGEAIERRIRGEGKRTEELSSIHQLGADGSEEDGTSSSTDTAEEQAVFERKHQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJI2</accession>
    <name>A0A232FJI2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_009874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000115">
        <property type="protein sequence ID" value="OXU30835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJI2"/>
    <dbReference type="STRING" id="543379.A0A232FJI2"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="580"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="951" mass="107867" checksum="8DB660845FE42461" modified="2017-10-25" version="1">MYRNLRLASRSKRERAAIWWNFIEGRAEHRKMPQRLYHSGSGVYGHRNRAPRQFEVPREELAARAQQSNFYRLLTAYREHGHKQAVVNPIALSKPRALPELRPEHFGLDLADNVRMEGLLRADKADATVEDALDILNRIYCGTMSAEFSYLESEEEREWFAKNFEECYYEALDDETRRAIAREMLKSQAFDRFLAVKFVSVKRYGGEGAESMMAFFHELFKLASNDTLKELVLCMPHRGRLNFLTGMLKFPAEKLFRKLRGLSEFPDDAKATGDVISHFVSSMELPLTGLHVSMLYNPSHLEAVNPVSMGRTRGLMQILKEGAYSDDPDAQWSDQVLNVQVHGDAAYTGQGINQECLALSGAPHFEIGGSIHMVVNNQVGFTTPAARGRSSRYCTDLAKFISSPVIHVNADDPESVVKATRIAFRYQRKFRKDVFVDLNCFRRWGHNELDDPTFTNPLTYKIIHNRRSIPDRYLDELINAKVLSQEQANMIVEQFTEKLAEALRRVDDYVPQATYFTGRWSQLKQADSAVTTWDTGVDANLLQLIANKSVQSPEELNVHPTLLKSHVESRLKKIESGSHIDWSTAEAMAFGSLLYQGYNVRISGQDVGRGTFSHRHAMLVDQSTGGTYRQYFLSKTFPLQTIFFTSEMYIPLNSMVEGQTGKIELANSILSEEAVLGYEYGLSITLPNTLPIWEAQFGDFFNGAQTIIDTFVSSGEAKWMTASGLTMLLPHGYDGAGPEHSSCKLERFLQLTDSREDRPDGDDVNMQVVNPTTPAQYFHLLRRQMVRNFRKPLILVAPKTLLRHVSATSGLDEIAPGTSFKTVIGDEKAQENAVRKVILVSGKHYYALEKHREILGAQDVAIIRVESLCPFPVAELNEEIQKYQHAKTFIWSQEEPQNMGAWSFVRPRFENLCGRQLRYSGREPLATSAVGIGQLHQRQSEEVVVKPFAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJJ0</accession>
    <name>A0A232FJJ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000109">
        <property type="protein sequence ID" value="OXU30901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6605887at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30092" checksum="570E57420D337B4A" modified="2017-10-25" version="1" fragment="single">MRLLAEDEIFNADVPSHYLAHHGIWQKGDRGRKLPSRRRIENQVLQEALKQVKVSYRYCGFVLQASHPIFGASPDGQCSEFVCEVKCPSSAKGFENFLPNCEINQKCKAQINLQMFSTGLTKGLFIVADPDFENTKQQQSLDSFETTVXENQVLQEALKQVKVSYRYCGFVLQASHPIFGASPDGQCSEFVCEVKCPSSAKGFENFLPNCEINQKCKAQINLQMFSTGLTKGLFIVADPDFENTKQVTLKWIEYDAEFTKLLMDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJN2</accession>
    <name>A0A232FJN2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000102">
        <property type="protein sequence ID" value="OXU30956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJN2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="180" mass="20703" checksum="CF43054FC566D731" modified="2017-10-25" version="1" fragment="single">SVHPTINKNFVNINGNESSFVVQGFLGSLNTNIVMEIISEVPGAQGRQSLNTNIVTAVLSEVHGAQGRQYQRHLLEFNGKLTTYFVEILYLKVFARSLGRQISHSCRINFCALVWKYTIAPTTQFIGKSSKNAKIRNETVPFCWFSDLFSHTFLYTFLHFQICLLFLQFIIFYYICYFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKX7</accession>
    <name>A0A232FKX7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000068">
        <property type="protein sequence ID" value="OXU31322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKX7"/>
    <dbReference type="STRING" id="543379.A0A232FKX7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF154">
        <property type="entry name" value="FI04917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1272" mass="142162" checksum="291C06D7B9C849F1" modified="2017-10-25" version="1">MTWTPADHGSFCGAYSSLATCQPDILAYVALLVQLLGGSLDENFSDVRRLGGSKGGENGPYDFIIVGAGAAGCVLANRLSEITDWKILLLEAGEEEPAIANVPGMCRILKYSSVDYAYKTEPQPILGCRRGKNHSDYWPRGKVMGGSSTINTMWYVRGNKQDYDDWASFGNPGWSYNEVLHYFKKCEDCRDPAIRADFPDSHGIGGFLTVERFPHQDRNSKTILNAWKELGFKEIDYNSGYTQLGTSRLQFHTIHGAHQTANGAYVRPIRGKRRNLFVKTKCLVTRIVIDPASKRALGVEYIDQNTNTVQYAHAKKEVIVSGGAIESPKLLMLSGIGPAEHLREAGIPLMQNLPVGANLQDHPMVYPIQFKMSDDAATFTSVEDMQDDLVYWLSSHEGPLSGLGLMDTVTYYQTSNEKLRGVPDIHFGFTGFISEPLNNYSFHYIPMSYYNEVRLSTTLLNPKSRGLVKLNISDPLGHPLIYANYLTHPQDIKVLVEGVHMARKIVNTRSFRENGFIHITTPAESCKNFPFESTAYFECMAKHYVTTAFHPSGTCRMGPRSNPSSVVDARLRVHGVIGLRVIDASIMPTLIRGNTYAPTLMIAEKGSDMIKQDWLGPRAVVIPRVQPSKTTQNRIPTRNLGSFMDTLRMTSERIPMLSSCQPQVLTLLRLIVQLLGYSFDDHFSDKSRQNPSPEDDFDFVIVGAGAAGCVLANRLSEVKNWKILLLEAGDEEPAVANVPALARILRLSSIDYAYHTQPEFTGLGNVSYYWPRGRVMGGSSTINTMWYVRGHKQDYDDWARLGNPGWSYDEVLPYFKKSEDARDPEVFKRSPETHSRGGYMAVERYPYQDKNTKIIRNAWREMGFAETDYNSGVQFGMSKLQFNTIHGTHQSANGAFLRPIRGSRPNLTIRTNSKVVKIIIDPDSKRAVGVQYLDSKSRLISVLAKKEVIVSAGSVESPKLLMLSGIGPVEELIQADIPLLKDLPVGRNLLDHPILYPFTFKLNEQASTLVSVDKMRDDLIYWLSSHQGPLSAIGSMDAIAYYQNCQKCFGRADIQFGFTGFISEIEKKTSDLKFIPSSYYDEVKVSLTLLTPKSRGILTLNKTEPVMGLPLIYANYLGHPQDMKTILSGIRAMIGITRSTTLRENGFEYSTVSEPGCENYVFESEEYFKCLVWKTLNSAFHIGGTCRMGPVGDPDAVVNPRLQVYGINGLRVIDGSIMPSLPRANTYAATIMVAEKGSDMIKQDWLPIMTATYNLWDYLSKPNGRIYVAQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKY3</accession>
    <name>A0A232FKY3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TEP1-F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016404</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000089">
        <property type="protein sequence ID" value="OXU31108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FKY3"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082235" description="TEP1-F" evidence="12">
        <location>
            <begin position="20"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="13">
        <location>
            <begin position="489"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="14">
        <location>
            <begin position="860"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="15">
        <location>
            <begin position="1500"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="713"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU31108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1894" mass="209266" checksum="D0366ECE82EFB654" modified="2017-10-25" version="1">MRRELSIVLCLAALSCAAGLNRNRGYIFTAPKRLIAGETENVCLSLHNLEPPVHVSVDLLATSSAVGVVTPASAGGALVEDDILGSAKNTLKSGVETCLELRVTSSTKYSAAKLRLRLKFDKHPEYVVDTEKKVFIEHDALVTFVETDKAIYKPGQDVNIRILTLRHDLKPWIKAIPKVWIENPSEVRVAQWTNVTTDNGMAQLTFPLSTEPSSGIWRIKVEKNRPQLVHTSTFEVRKYVLPRFQVTIGAPSYILADAQNATWKVCVRYSYGEPVKGKLLLSLRPQTPIWKRKQTVADINYEETLDAKSDGCMNYTVSAQVLGLPHWKVAPNNVVLLANFTEAKSGVVETATSRSPVMHQPLKLEFSPHTLKYFKPGLPYHGKLRVLRADASSPAPNEKIQVCLRIRRKDEWQRSVVECRNFTSSNADGFLDFIVPPQNKNIVLLSFVATAVNYPTKYYSPDKRWRVFVDQPSAYIDVEPWYSPSSSYLSVTRGSQPLVCGEKYSFNVMYTSGTSSTVNATNLSPDDTEPISFHYSINSKGDLLVFGHVKYKPRKDTLLDYSEFRHVLGAGAGSKPNPSVHRFPLSVKITASMAPVSELLLYYVRPDGEVVTASHSIEVGHCFENKVKTAWQQEKQSPGSLAKFHVEATPLSLCGISAVDKSTRFLTQSQPVSSEGGSAASTGSNLLEPEATFARLKPFHLPPETMPMQSTWAHCDKSQGAEDSNSEEGPIEEIDHLPKPAARNKRHSVTYNVAANYVDAIQAFDDFGTIVMSDLILESRPCPPWRSSFGRVPLGPSSDEIDEPDRMLKAVKAMPLAFQFGAPGIPGPEASPMGQDVNYVNPTSMESQTSTIVRSYFPETWIWELVPTGKDGRATIERQLPDSITDWIGNTVCISSKSGLGIGNPVQITSFQPFFLDYSLPYSVKRGEQLRLKVSLFNYMQHSLPVLIKLLDHEGLDLGFNSSSEASYCLGPRDSIVHEFPLLPRELGEINVTVAAEIDKERAEACGAPTPLPDNRRMARLIRDEIIKPVLVKAEGFPVEISRSSFLCPRDFSDDTSLVWELELPRPEDEQVVEGSVSAYVSLIGDVLGPALENLEQLVRLPMGCGEQNMILFVPNIHAIAYLDAINRQTGSEMRARAIKNMQKGYQRELNYRHPDGSYSAFGAAADEAGSGSMWLTAFVVKSFAQARSIIQIDERDLKLSVKWIVRRQLENGCFPVVGQVFHKDMKGGLREEDGSSSALTAYVLIALLESGIPLSAALVNNALYCLEKASVSDHFADNPYTGALTTYALALLEHPRANESLRSLMGRASRQKDLLWWEDKSRPGSLALSIEMTSYGLLSLIKLGGENNTLEALRVVRWLSKKRNAEGGFSSTQDTVLGLEALTKYALKMANASATELSVLLTANDMEKLFKINDENRMLLNRVELPTLPTTLEIFAEGEGCLLVQSSLRYHKAKASGSEAFDLSTSTASVSTADQTPNDGCSIQRLTVCTRYKLPDEESNMAVLEIAMVSGFRPDRVSLHDLLDEHATGVKRFEENDDTVAIYFDKLTAQKTCISFQAIRENVVDHAEPANIKLYDYYQQELTVSTSYAFMGVCEKNKTEKAVINHEANNPAPRKMQQLDNRLSVNQLPEKIDGIFEIDMTREKKVDPSIFKQRSSGVTIPATISIDLDEGSGIEPDGELFSPSPILPNIDQDVVDEGFSPAFIDVDHELETPNGIEGPIPFYVEAPVSTTTKESVFAQTPLNVNPSLNFHNSTKLKTEETKISRSLASCPRCEEGIPSDIKELYCSSASAVKVAIRRSRKARLLLDLSSSSASTRLRSTIELNIKPECSCAPLDKPGIMALLLSSKDGFNFAKSSDKSKALLDRSNSMFALTSVIGTPHEIQEAQLSCSRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKY8</accession>
    <name>A0A232FKY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_009422</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="EMBL" id="NNAY01000079">
        <property type="protein sequence ID" value="OXU31180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKY8"/>
    <dbReference type="STRING" id="543379.A0A232FKY8"/>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23434">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000065">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 16" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="335"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU31180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="460" mass="52605" checksum="06A440D68C285DDE" modified="2017-10-25" version="1">MELFVFLIRCSFWGFMCRLKQWKQDLPATSVIITFHNEARSTLLRTVVSVLNRSPEHLIKEIILVDDFSDHPEDGEELSKIHKVRVIRNEKREGLMRSRVRGADAATANVLTFLDSHCECNADWLEPLLERVTEDPSIVVCPVIDVISMDNFQYIGASADLRGGFDWSLVFKWEYLSQSERQARLKDPTQAIRTPMIAGGLFVINKTYFEKLGKYDTQMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYSFPGGSGNVFARNTRRAAEVWMDDYKQFYYNAVPLARNIPYGNIQDRMELKRKLHCKPFSWYLKHVYPELIIPTSEGGPGGSLKQGTACLDSMGHLLDGNVGLYPCHDTGGNQEWSMTKDGLIKHHDLCLTLPVYAKGTSLLMQICDGSENQKWRHLEGGLIRHARIPVCIDSRYHAQRGVTAEKCDSNAESQRWHLYNHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKZ6</accession>
    <name>A0A232FKZ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein unc-104</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_005862</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000061">
        <property type="protein sequence ID" value="OXU31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FKZ6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021700">
        <property type="term" value="P:developmental maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051222">
        <property type="term" value="P:positive regulation of protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040012">
        <property type="term" value="P:regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051960">
        <property type="term" value="P:regulation of nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000001">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000004">
        <property type="entry name" value="Kinesin-like protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000204">
        <property type="entry name" value="kinesin-like protein unc-104 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="3"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="1624"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="953"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1985"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2066"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2169"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2208"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2331"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2368"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="624"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1987"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2370"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2381"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="2430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2430" mass="275561" checksum="86391FAA3BCA8365" modified="2017-10-25" version="1" fragment="single">MSSVKVAVRVRPFNMREITREAQCIIEMTGNTTSIANPKAPPGTKDAIKSFNYDYSYFSMDPNDENYSTQIMVYKDIGEEMLEHAFEGYNVCIFAYGQTGAGKSYTMMGKQEEGQEGIIPQICKDLFRRIGDNSSNEDMKHSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVMSYEDIHNLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQQKQDNATGLVTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEIASKDKKKKKADFIPYRDSVLTWLLRENLGGNSKTAMIAAVSPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKIIRELKEEIQKLRELLKQEGIDYQEGDVTSFIRNAKREDDTKESRQRIPSHGTSTLAEEAVEQLQASEKLIAELNETWEEKLKRTEAIRLQREAVFAEMGVAVKEDGVTVGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGFTRIGSAEANIPQDIQLCGPHILSEHCVFENHEGLITLIPKAGALIYVNGRAITEPLLLKTGSRVILGKNHVFRFNHPDQVRERREKSSPAETPANGETVDWNFAQIELLEKQGIDLKVEMDKRLLVLEEQFRKEKEEADQLFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYTPEDFNNIEEDIFVNPLFDAESNWGEREFQLASWAFRKWKYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPDLLPAVEDDEEEERPFPRTIVAVEVQDLKNGATHYWTLDKLRQRLELMREMYHNEAELSPTSPDYNIESITGGDPFYDRFPWFRMVGRSFVYLSNLLYPVPLIHKIAIVNEKGDVKGYLRVAVQAVVEEENSEYSSGVRQSARISFDDDLFGTQRQNRRNTLLAQTLEKNQQQQILMQEERVVEGHNENKEIKSNENCKELKEDEEVGDADSGRGDSSVSSDMKEEELPEHLQIGAEFTFRVTVLQAMGIATEYVDLFCQFNFLHRHDIDTFSTEPVKNTGKGNPPGFYHVQNVIQLSTDCVSKITNSQSYVRALYFQITVTVTKSFIEYLKTQPIVFEVIGHYQQHPLHKDAKLEFVRQPPKRMLPPSIPISQPVRSPKFGSVLPSPSTSHVHAKYDVLVWFEICELAPNGEYVPSVVDHSDDLPCRGLFLLHQGIQRRIRITIVHEQASELRWKDVRELVVGRIRNTPEPEEEDNDSSVLSLGLFPGEYLDLPGDDRCMYRFEAAWDSSLHNSALLNRVTSYGEQIFMTISAYLELENCGRPAIITKDLSMIIYGRDARVGPRSLKHLFSGSYRNQEANRLSGVYELVLRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLDGWRPRGDSLIFDHQWELEKLTRLEEVERVRHTLLLREKLGIDKNIFCNKTVHDFTKSEKEVCNMVAKATNEPHASPVKLKKSTSKDVYEPWEMNEREKEIASKYVKLIQGRIPSKEPIVLSDVSPGDDTITDMTTSMMSSVVSSSSQESVYPRLCDYEQSAGIIVKSRSKSCIFRLSSPERARLQELQESILAGSGGDTASAPAPLGASSPLKESLVLYVPEVEEIRISPVIARKGYLNVLEHKTNGWKKRWVSVRRPYVFIFRDEKDPVERALINLATAQVEYSEDQLAMVKVPNTFSVVTKHRGYLLQTLGDKEVYDWLYAINPLLAGQIRSKLARKGPGANGIPISLAPPAATSTGVGLADTQAQANDPHASEYALTSIAITINADAAFLFLCFVCKIDLINFYINALARRNDVDSFVASRLSRVFIRVSVEAFFLGPLLIHQHHVFVEHDSLKIDNKVGILSILPAPTQVVWDREDEAREAKLRQRPVSALVKAVVSAPPYGQRKGWVPRNEDDFGDGGAFPEIHVAQYPLGMGEKGKETTSNALAVQLDAQGKVKYDLIARQGHSKDKIVYSKLTDLLPAEILTEDDPNIQKRSEEEAEETTEKTKRALEKITESKIAAAMPVRRAEKQGPAQYIRYTPSQQGQSFNSGAKQRVIRMVEAQVDPMEPPKFKINKKIPRGPPSPPAPVMHSPTKKVTVKEQKEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQQTHINENFAKLAEALYIADRKAREAVEMRAQLEKKLAQKEKEKKEDHLRQLAEKARNERAGLKTAAVLDKNEEIRDREQIRQDRHKERARERNLARAAPDKRSRLQRERERDISEQIALGMPAKNVNTTGDQAFDQRLFNTTKGMDSGYGHDDEYNVYDKPWRDTSSIGSHIYRPSKNIDQDNYGEDLEKLKSTSRFVPDKEFSGADRTGAGRSGPVQFEKEEEDPFGLDQFLKQAKRASNTAPTTATKRKDDGHSKKDDNRDKRLLLKYCGKPFCSIRHLLCILNKIGSTRGFCYPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKZ9</accession>
    <name>A0A232FKZ9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000073">
        <property type="protein sequence ID" value="OXU31263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKZ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="233" mass="26678" checksum="A001EAF88CF37AC9" modified="2017-10-25" version="1">MIVEDIVGDEQVRLTDKSVNKQSILTIVNSENLCLPRSLVTAYTKDTHKCGISICTKCNSRKKFSKKDRLGILLPRGYIMTDNQHRSLWLQFHGCFWHSYPRFYTINRDIDLTSGKSMDARYEKTLSISDRCTTANYQLFKNGYNKRNIKRKLFDLRNAFFGGRTVNTVKVFDCQGQEKIKYVLCIPLLANTASENGEYEVPISTSLGSLTDELSDKGTGTYITVHISIRLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL86</accession>
    <name>A0A232FL86_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000072">
        <property type="protein sequence ID" value="OXU31269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL86"/>
    <dbReference type="OrthoDB" id="6133584at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7850" checksum="FF4DB70A7403E36C" modified="2017-10-25" version="1" fragment="single">SKRAFSLAFDVSVREVTLSELRDSVARYRDRVKLVCRTRGSPPPRVHWLKDGVPLQPRRGLRIQHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLQ5</accession>
    <name>A0A232FLQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000046">
        <property type="protein sequence ID" value="OXU31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLQ5"/>
    <dbReference type="STRING" id="543379.A0A232FLQ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="198"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="776" mass="88544" checksum="91C6AF1BF2332415" modified="2017-10-25" version="1">MDAPTDDVPVDNFLILEINQIQTEEQLDDVANKLIARFQTYAGINKTFGGLRISKAKKKGPNAQTKKPRIDRNNKNVIQGLYRNQQHRAVQEILFGPTFDCYIEDAKIEKHWHSVFGVKSECNISELPPFLWQNSTPTENYNVYLEKKFSSKEVRDKLQQKYRSRLSNSRSVGLDRIKYRTLLKYDPKSLILTAFFNACIQLQKVPKVWKLPYSVLIQENKGDDDNIKSWYLITMHSTMSKLFQSLIAARLISWSLNTGRLSATQKGFLLNNAACESSFILQECKNYAQKCKKDLVVAWLDFSKASDSVPQEAILHALQRHGVPTSIRNIIESTLDGAQTKIRTVNEAGFTNPITILKGLPQGAPLNPILLDLVMEPILRNLASESSNMFQIFNKKINHFAIPNELTLIAESMTNLQNLLNIVEKTAKSIGLQFNVHKCSTYHYDSKKNETQKTSFKFYGQDLNILPEKEIDRYFGVKQGLSIGQSGIPTVEEMIESIEGIGSSKLDCFQKIDAVLTFIIPRVENCLRGLQNIKKTPLDEADKTLRDKLKEWLSLPKDCGIDSVVFQASAEMLRMKTKYLPFLDLLYVMKVVQALKMFNSKDEIVQCIAFESITKEVSEVVTKQLKDGITKKTLASYLSGDLPIKNTESNSMWFMVREATLQLKIKIDLSWEYKDKRMLITVKDNIKMKRNINMSQFEEDLKNCLISYYINEVKKRNPEADAVVNPKMTSSTPKSHKKGSKAERQLKFQKLNAAPVQPIIPITMLMSNFPLLNAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLW4</accession>
    <name>A0A232FLW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000053">
        <property type="protein sequence ID" value="OXU31499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="203" mass="23835" checksum="655C00EA80B9B4FE" modified="2017-10-25" version="1">MAENRDNYVSNSIRLIQFHIVRNLKYYLWGLYHFLYRPRKQLSHRPNSSQDKYWNNVVYNLVVGSFVDFIVLYFIHLPEFLARNSWKFIFQLCIMAACIYARKSWVQPFKNDWLTVASSGLALFLLHLNDHDLTIVICIALLTGSQKLYYTKSNTWFIREVIYAAVLLAIVGAVYVANLYDISVVIVLYAICTSIFTPYMYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM49</accession>
    <name>A0A232FM49_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000040">
        <property type="protein sequence ID" value="OXU31653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM49"/>
    <dbReference type="STRING" id="543379.A0A232FM49"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="58"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU31653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="368" mass="40768" checksum="4F7236DA9974286B" modified="2017-10-25" version="1">MENHSSIHSYMQVALNADDLSMISAAQAKSYGENASSRNKAETVLASNNKGGLTNPRALLFLILWYIFSGCTLFLNKYILSYMEGDPTILGACQMLMTAVCGFIQMYFPCGMYQASPRLTRPPGFYKHMILVGCTRFMTVVLGLVSLNYVAVSFTETIKSSAPLFTVFISRYLLGEHTGFYVNLSLLPVMGGLALCSANEISFDLRGFVAAMATNLTECLQNVYSKMLISGDSFKYTPAELQFYTSLASVVVQIPASILLVDIPALEHSLDLNLLTAFIMNGIFFHFQSITAYVLMDYISPVTHSVANTAKRAFLIWLSILLFNNPVTGLSALGTFLVIAGVLLYNKAQEYDRLKNLRRRYTSKVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM63</accession>
    <name>A0A232FM63_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_007012</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000043">
        <property type="protein sequence ID" value="OXU31610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM63"/>
    <dbReference type="STRING" id="543379.A0A232FM63"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000077">
        <property type="entry name" value="Sphingomyelin phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371209" description="Saposin B-type domain-containing protein" evidence="14">
        <location>
            <begin position="24"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="15">
        <location>
            <begin position="112"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU31610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1227" mass="139619" checksum="00E55D07BC028B44" modified="2017-10-25" version="1">MWSQRQLLWHGLVLFSYIAISQADVFVVDQKPNDFITHGLTNITNNETSPNILDPITDALDPDWLTSINYTRWMMGLEDAISKGDTNLWAQTINKTFDLPRVIEEIKTSTESKATCFACKFIVNLGRSMVKSNKNDQEILNLFGQLCTILKIQTERVCAGTMALIGVDVLEAVKKSDMSSAQICSFLRGDVCLNGYDERHDWKINISKQNHTPTHPTTPPPENVPVIRILQISDTHFDPYYEQGANADCGESLCCRATDGEPKSKEAEAGKWGDYRKCDAPLRLIENALKHISETHKDLDYIYWTGDLPPHDVWNQTREENLLNLRLSAALMDKYFKGIPIFPSVGNHESAPCDSFAPPGSPARKNMSWLYDELDKEWSRWLPSSTSETIRKGAFYSVLIKTGFRLLSVNGNYCNQNNYFLLWNSTDPVDELAWLERELAAAEANGEKVHIIGHIPPGVPDCLKVWSKNYYEIISRYEAIVMAQFFGHTHFDEFQVFYDTKSFKRPVGVGYVSPSLTPWENVNPAYRIYYVDGDHPKTSRAIIDHETWKMNLDEANRNDNPVWYKAYSAKRAYNMSSLLPKDWDNLISRMNTDKYLFETFHSIERNTVYHNLYGFLEEETSFQQTVLNLGYGGLHFLAEGEEFLANQLKDKTPKFGEEYDFIVVGAGSAGATIASRLSETKNVKVLLIEAGGYENLIMDIPVIVNYLQFSNDINWKYQTEPSESYCRGLRDRKCNWPRGKVMGGSSVLNYMIATRGNPLDYDKWAEMGNEGWSYAEVFKYFQKLESMQIPELRDDEKMHNVDGPMRISYPPYHTPLAESFIKAGLEMGYPTIDYNANQNVGFSYIQATIMNGTRFSTNMGYLQFPNKRQNLFLSMFSHVNKVLIDSKTKRALGVEFTKSNRTIRVRARKEVILSAGAINSPQILMLSGIGPVKHLEEMNINVVQDLPVGENLMDHIAYGGLIFLVDQPVSIATRDLMNPMNPYLNDFLIKKVGPLTVPGACEALAFIDVDNPNKLDAYPNMELLFTGASIVSDYALRYTVGYSDEPWNKMFAPIFGNYSWMIFPMLMQPKSRGKILLRSQEPMAKPRIIANYYDDPEDVRISIKGIRAAIEVSKTKSMQKFNSRIHDVLVPGCEDHEYDSDDYWECALRTFTFTIYHYSGTCKMAPENDPTGVVNPRLQVKGIKGLRVADASIMPSIITGHTNIPTIMIGEKVADMIKEYWKKKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMG7</accession>
    <name>A0A232FMG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="15">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016754</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01000024">
        <property type="protein sequence ID" value="OXU31845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMG7"/>
    <dbReference type="STRING" id="543379.A0A232FMG7"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.55.10:FF:000001">
        <property type="entry name" value="Leishmanolysin like peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="13">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU31845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="579" mass="66509" checksum="486769665374D882" modified="2017-10-25" version="1">MEMDEIGRLRTRVAVVCIWYNFVTFRCRKCQSTQVFVKDNLTHCIDTCRSETMCGEVVVPEQHLDACRVCNKAGLNCRVEPASVPGEGINGADFVFYVSAMSTERCKKGLTVAYAAHCQQEAALDRPIAGHANLCPESISTKPQELETLLSTVKHEILHALGFSVSLYAFYRDDRGEPRTKRTETGKPFLNTTLQTHQWSENTIRTVIRHSWQVHGGSVRRAMQMIVTPRVRAEVRAHFDCRDLEGAELEDQGEDGTALTHWEKRVFENEAMTGTHTQNPVYSRITLALMEDTGWYSANYSMAQELGWGRKLGCDFAMKSCKEWIVAKSSKFSGRSIHPFCNKVKRDPLQTECTDDRSSVALCNLVEYPQPLPKQYQNFDWIPNVPRGREEYYGGSVSLADYCPYNQEFTWRANNTIVRGSHCLYEDNNPHPKKNFALEKYGENSRCFDHTNQMWEERTCKQVRQWQHWGSGCYQYKCEAGRLHIMVTNYTYTCYHAGQEIAIRIMQNEWLHKGALICPPCRDLCQEEFAQRKEQCKPGDEHPPATFYHRDRLDCDKASSNSLNISILVSIIALLFVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMS2</accession>
    <name>A0A232FMS2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000014">
        <property type="protein sequence ID" value="OXU31972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMS2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="19388" checksum="B6CB7CCF7D9790C5" modified="2017-10-25" version="1">MNLTNTEVQEIIHGTEYRIEIWEQGFRTLQPSIVKSIEKVGNLKRIGTQRGEKREGDRGRDRIGNTLKQRKLEDSLKSKEERKRRKRRRKELVSEGVKVKRTPQETEKMGEDIAKIVKKTMDIILHKVDEINTNMDGKREDREKMIESWEQRYIGLEKKLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMW2</accession>
    <name>A0A232FMW2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_014087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000022">
        <property type="protein sequence ID" value="OXU31859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMW2"/>
    <dbReference type="STRING" id="543379.A0A232FMW2"/>
    <dbReference type="OrthoDB" id="445936at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140965">
        <property type="term" value="P:secondary piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="PAZ" evidence="9">
        <location>
            <begin position="325"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="10">
        <location>
            <begin position="602"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU31859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="904" mass="102976" checksum="D61BABD4E0B51578" modified="2017-10-25" version="1" fragment="single">LSQHNVNMGDRDHDVRRGRGGPRPLNNEQQPGTSQGRSRFSSQRPEPYPRRPGATAERGAEGYPPVRISPEYQRPSISTGPAYPSPAHREDIRIIEHRAQPAYSDTTSDTASVAGSVDGAVSVASSIEKDGMRGRRILPANVITRPDTLVSKQGTHGDPILLTANYFKLLSTTDWCLHKYRVDFSPEEDRKVVCKGLLRSHKNILGAYIFDGATMYSSKRLPDLLELTAERAGDQQLMLIKIRHTGEMTRGDHDYIQFFNIIMRKCLDSLQLQLVGRNYFDAGNKIEIPEFRLELWPGYITSIRQHEHDILMCSEITHKVMRNETLYDVLQQCYHENSREFKNLFSKQVMGVTVLTDYNNNTYRVEDVDFNVTPASTFKKKTGEEISYSEYYKTKYHLRIKDMRQPLLVSRSRSKDRRAGQEELVYLVPELCRSTGLTESMIKDRRLMSALAQYTRVSPRERIQKLMKFNTRLHSVPNVVTELQNWNLKLDKQLVTLKGRVLPADTIFYHDRDTSTVNRTANWTNDFRNKKLLKCGDLTDWAVVVPYRLTSDCEKFVNQIIKVASTMGFKMNNPALREIRDDQPASYAQVLENIKSTSNPMLILCVATNNREDRYNAIKKKCCIDRPVPTQVVLAKSLQHKNSMSIATKVAIQMNCKIGGIPWSISIPLKGLMVVGFDVCHDKNDRSKDVGAMVASLDPCFGRYFSAVSSHSSGEELSNDLSVNLCKALDQYKYYNEALPNRIVIYRDGVGEGQVPFVVSHEVQQVKSKLEKIYDNPNNIKLAYIIVTKKINTRLFANYQNPPPGTIIDDVITDPTKYDFMIISQHVTQGTVTPTSYNVVYDTCGIDADKLQRLTYKLCHMYFNWSGTVRVPAPCQYAHKLAFLVSQSLHQPPSDVLKTLLYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMY8</accession>
    <name>A0A232FMY8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000020">
        <property type="protein sequence ID" value="OXU31880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMY8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="22" mass="2772" checksum="FD1BFA3F5FBDDCFE" modified="2017-10-25" version="1">MLFVDREQGSQIRDCVHRRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED30</accession>
    <name>A0A232ED30_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01008964">
        <property type="protein sequence ID" value="OXU16251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED30"/>
    <dbReference type="STRING" id="543379.A0A232ED30"/>
    <dbReference type="OrthoDB" id="6622541at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="490" mass="56125" checksum="8820074B2176FADE" modified="2017-10-25" version="1">MDVVIKTGFETILHDIVFQPETVPKGKALVAANHVHNVEEHRKNGVSYLIQAQVIRQASVTSTPYSTQLNIDADRKIINVSCTCVYNKSGKCKHISALIYYVNNTDSLSKTDCEQQWGKPTTRQLVQEKYSKGRYFWEMFPPKEKLAVSDRQMELDISALTDPSPLKTLLLESKKNKNDKEIKNLMDSMLKQVDVILQKEECTKYLNIIFAFCEKKEVYAKNQIVTKDAYDYYQENIAMSRKNIIKLCSDTIDQANNEKWFDARSLRVSASKNVHEIKVRKTKTVESLVSQMLFPKTVKTAALSYGKENEVNAAKKYEKVYGVKVTKIGVLVSEKQPWLCASLDGIVIENGNIVKAVEFKCPSSCEKIPVVDFNQKKCNVNYLKFNEENVILKESAIYYTQCQVQLYVTGLNECDLFIYSPVQNGCVCIPVQRNDKFLKKVIEKCEDFYFKDYLPELYKKNKKHEVLCKAKLKAKGAVFTGLDITNINRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDC1</accession>
    <name>A0A232EDC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007296">
        <property type="protein sequence ID" value="OXU16333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6496153at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU16333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="645" mass="74013" checksum="CD2AD67ACE89DBDF" modified="2017-10-25" version="1">MGYRSCCVRNCKNNELKSICKFYTFPSGEFKLERRKKWIAAVRKINSYEWQPKKLDFICSDHFIGKTTSNKEAGPGYIPSVFCSDVSLQRRRNNIREAAAVSRHARFMRRRLTTMRTKQDEPVQENMNEYDTISDVDVHYEDSVLDSVEVQHARFMRRRLTIMRTKQDEPVQENMIEYDTISDVDMHYEDSVLDSVEVQSETPKYLDKVTDANIFIDASEPQTSFMCNRYITNGSNKCDTEVQTDILTVNSQTIILNPRKLRNKKCGMTQQTFVDTVVGPDSESVQDNHKTCLSYALVRKDEXVTDANIFIDASEPQTSFMCNRYITNGSNKCDAEVQTDILTVNSQTIILNPRKLRNKKCRTTQQTFVETAVGPDSESVQDNHKTCLSYALVRKDEQLLDLAGVTHNNFKFLLKRIHDLTGSYSKISKENKLFIFLIKMKTGLTFSAISVLFNVPRTTMSRIFFEVLQELAKTTANLVFWPAKDVVQGTMPAYFYPEYKDTRVIIDCSEFRIEVPASVDNRVFTYSHYKKGFTAKLLVGITPGGYISFKSKVAGGRMSDSQITIETGLIDLLEDGDTVLADKEFPQITRVLDEKGKKVVLVMPPFLEKKNRIYKRRDSKYLQHSKSSYPCRKNNAAIENIPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEC1</accession>
    <name>A0A232EEC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005459">
        <property type="protein sequence ID" value="OXU16662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEC1"/>
    <dbReference type="STRING" id="543379.A0A232EEC1"/>
    <dbReference type="OrthoDB" id="7693469at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU16662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="762" mass="86283" checksum="5AFDAF4FC533F161" modified="2017-10-25" version="1">MRRDQPPRAVKQSIKRLQEQRATRRSAEATRIVAPIKNVKMSDEQLQKELAEEKATSEALQQENAVAAKTVEDMRARMRELEKRLTTDLTAGTPAVRQPANAVTRDEQQLSTPQPGYTQSDAGIEKMPAWASTLALVMRSCITPVPPPPQRPRIAYIDEANTLTKFSGQDELLPVKSWKRSVDELAAAGMGTRHFAAKRALTGAAADWILTRSDLQSWIPLGKAIESTFEYEVDEFHIMEKLMRGRPKKDEPLIQYMHHMRRLASQANISDKLTLKYTVTGIPDNAFNKVLLHVCTNFEELKKALANYEAARREQKEHSNKQRGDQHAPKPNGGHAKKQEDKGREAGKCYNCGHTGHKSRECPEKSKKPKCFACNLSVHISRECTNKLNASQREKTKAVNLVQEKEDDSIYLVQNEEKSNSHVQVLLGGVEVSAMLDSGARKNILRADQWDEIRKATSPVLEVTEYLGQLKGFGRSVVRTPELVTLPSVVDGAQYDLEYLIVPRRAVEERVLIGDPLQKMARLIFDPDRATVVPLVGTVYIRLVQQELDEAERVMDAVSTKYQAEVKKLVADYKPEGRETAPVKMHIVMKNEVPISCRPRKLSPQEAGINEKTPMPIVEDVLESLSEAVVFSTIDLKNGFFHVEVYESRKYTVFVTPEGQYKFCRVSFGLSTSPAVFTRFVRYVFAELIRRKVIVLFMDDEIIKATTYEEAIDNFKKVLETAARFGLKINWKKCQLLQKKVEFLGHVVEGGKISPRRPRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EER8</accession>
    <name>A0A232EER8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005223">
        <property type="protein sequence ID" value="OXU16859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EER8"/>
    <dbReference type="OrthoDB" id="7545861at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032135">
        <property type="entry name" value="DUF4817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16087">
        <property type="entry name" value="DUF4817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4817" evidence="1">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="11100" checksum="2476EEEE089B458E" modified="2017-10-25" version="1" fragment="single">MADYGPNEIVDMIMILGESRNNYAAAARFHAERCPNRRHPSNVTIQTLTQRARNGAFVRQRRHHEYDENDPRVITILAIIHLDPHISTRQIEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF16</accession>
    <name>A0A232EF16_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Selenoprotein P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005158">
        <property type="protein sequence ID" value="OXU16937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF16"/>
    <dbReference type="STRING" id="543379.A0A232EF16"/>
    <dbReference type="OrthoDB" id="6134775at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001887">
        <property type="term" value="P:selenium compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007671">
        <property type="entry name" value="Selenoprotein-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037941">
        <property type="entry name" value="SeP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10105:SF2">
        <property type="entry name" value="AGAP003297-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10105">
        <property type="entry name" value="SELENOPROTEIN P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04592">
        <property type="entry name" value="SelP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325592" description="Selenoprotein P N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein P N-terminal" evidence="8">
        <location>
            <begin position="160"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU16937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="734" mass="83309" checksum="EB88E5132B4F1F5E" modified="2017-10-25" version="1">MRLIIFLLTALWYDSSSFGHVQAEPRSSNTRLIPRRFNSRLWKRQADLGYLEQCSILQFWDKQIGRVNVLAFFDSSWQFSHRQAAMLKVLRERFDKTGFDNIQFFAINASPDESQYIDRAEVEVEEETWKQISPSEAEGRPPVVVSPEALIEALGPDVYFIQDNDELQIWSKLRAFRDQILVIDRCGRLTYQVIVPWSILHFPYVKAAILSTYKDEPCGYCQFKETVFDTTPTDNKDAQSSSKLVEQTEDNDNPSTLSQETTTVIHEAESHDTTWTVDESSSSIVQTEHEVGNETSSVSQESEDSSTIIRQTETDDGQASSTIYQESSTLSDLVENSESSSKARESTTDISQINDGEEQSTYFHDSSTPSYTDESNNTESISEDQSTPNIQTEADSTFDTSTYLYSPTLPDSNENESANSTDNKVAEDYYYSTPDKEFEYTTENVETPATDEALITDTTDGLEFNNATDQLISEIEVQTTTDISNSSSETGESRLKDSDEIESLDARDVLKSRSTNARSVSPNDGSENHLEIVNINENNQETLESDFLIPIRIIMRAPHVDEYSDQTMKAHEYLVLKTGQADYHEHLDEPKPDDNEEEHRPVRKKAEAVRRTFGKDESPGFYGEVADYWRNFGNEQLTQSSVEEEEQDLEDYTDDGVTLSPTTLSLNDERINVENQYDNPEVVPIGQVGVDDGTAYDHNSDLKEEVDVVDEEAKSKLIAHYSKLLPWLYYVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF21</accession>
    <name>A0A232EF21_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005188">
        <property type="protein sequence ID" value="OXU16912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF21"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="25" mass="3065" checksum="78DEDF0002068AAF" modified="2017-10-25" version="1">MGCSIFLLWCVYFFSHQHLKRTFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF99</accession>
    <name>A0A232EF99_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005097">
        <property type="protein sequence ID" value="OXU17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF99"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11773" checksum="78F380AB5073C3FE" modified="2017-10-25" version="1">MKPIVKTERSRPQSFMYLDSIGFISSQNNIPLIDHLSRHCSNKTIDLSINPLQLKTTYSTTLPDRDINDKYKFNRKYWWLAENPRTRDEIRRRRYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFU0</accession>
    <name>A0A232EFU0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004935">
        <property type="protein sequence ID" value="OXU17213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFU0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="8068" checksum="673DA974F33BBA71" modified="2017-10-25" version="1" fragment="single">LRYTISTIPAKSSKYFASFNKKNPFQNHPRSPTRFGISLRKLSRLKNPPRKLSRKHICYITHNPSQKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFW5</accession>
    <name>A0A232EFW5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004918">
        <property type="protein sequence ID" value="OXU17246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFW5"/>
    <dbReference type="STRING" id="543379.A0A232EFW5"/>
    <dbReference type="OrthoDB" id="438726at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23064">
        <property type="entry name" value="PDZ3_INAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06672">
        <property type="entry name" value="PDZ8_MUPP1-PDZ7_PATJ-PDZ2_INAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF84">
        <property type="entry name" value="LIGAND OF NUMB PROTEIN X 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="460"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="575"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="708"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="800"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="883" mass="95552" checksum="AFB146BFCD3B8CC6" modified="2017-10-25" version="1" fragment="single">PSSSAPVEELEAETLDYSSSHSLLSASYGSPKREVETQTQGDHKSTQYELEDLASLVDDLYDASSDSRERLEFLLEARFGSPRREVEVQTEQESKACQCELEELEASGEFGPFYRGAASYASPRREAQVQTGQDSKCTQCDFEEFGELPETLLSKVQWREPLDTEVKQPPDRRAVECSASSIESSSPGSSSPQRKSPPLIVLVKGGGKIDMTVTHRDKDGNVVWAKHWGPERLVEIYREPQTSLGLSIVGGKLYISYVKFKAVQSSPLRQESDEHDNLQVDLQEGGGSSKSQNVSGIFIKNVIPNSPAGRAGGLQEGRPELKRQATGGGSDAAGPSGRRSSMKKSMRKRAPSPPAGGTLREVSEERGGSDDMPKPKPKPAEAPKNKYSSGESSGEEEEDTRDLEGNVYTKSGVEISRKSAGNVKRSKEEIAADPDQEDEFGYTPSKVKKKYHFLKKPVLFVTLEKDRRGLGISLAGHKDRNKMAVFICGINPSGVAAKDGQLQIGDELLEVNGAVFQGRCHLNASSMIKGMGAMVFKIIVVRRPNAIENCAVKQVLQFPSALAGEDYSHLKGVRAVPIKKGTYGLGIMIIEGKHAEVGQGIFVSDIQEGSAAEIAGLNVGDMILSVNADTVMGATYDEATALLKKAEGIVTLTVCNPNQSKVAEEEERKAKGEPEAVKEAKKEPEKPKEPEKPADPKDCPIRDNKDTTIEFPKDKDKPIGFTVVGGNDTPSNGVFVLDVFPDGAAGKDGRLQPGDRIVDINKESFKAMESDKAYQTVLRITQGPIIMIVHRDEKAVEEFEVELTKKSGKGSGLVLMGYKSGKGAYVSEVVAGGSAAESGKIVKGDRIVSVGGQDLREAPVEDIALHVKVSNPVQLKLARYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG39</accession>
    <name>A0A232EG39_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004890">
        <property type="protein sequence ID" value="OXU17288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG39"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="15408" checksum="29ACCE07F60D3C57" modified="2017-10-25" version="1">MGLQKKRPPQQSRSRTRSPDLRENRFKTSTSRRRSMELQKKQQLPRQSRLRSRSPCGSEDYFEASTPKKSKVMEQEQNEFLSRNDTLLLTQSPDGSKNRRRDVMELQGKQPYRQSRPPRSRSPDGSNDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGN3</accession>
    <name>A0A232EGN3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004724">
        <property type="protein sequence ID" value="OXU17516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGN3"/>
    <dbReference type="STRING" id="543379.A0A232EGN3"/>
    <dbReference type="OrthoDB" id="6732784at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013122058" description="DDE Tnp4 domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="169"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU17516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="289" mass="33433" checksum="5562883793CF81AC" modified="2017-10-25" version="1">MKVSTVSKLYCCLQLLVLAAKLIEAWQFEQSKRWINRLWLRHPINQRRLSHGFFATQFQDIKLDDKLLFQYIRMDLEIFNNLLSMVQPYLRIRKRRQDAISAEYLATGDDILSIALSYRLSRSTVYSIIKRKYAVIRQVLSPIYQGLNRIGNYLVALAQLIKNISLSNVLQNSGALFFNYKKFYSIVLLAACNHRYEFTLVDVGAYGSESDGGILARSEFVRLMYCPSNYTDKESDNGDIISGSWRNEIQINNIEASANSRRAVEEAHKMRDLLANYFDSLEGQVSCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHH8</accession>
    <name>A0A232EHH8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004495">
        <property type="protein sequence ID" value="OXU17816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7697906at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="204" mass="23700" checksum="1422F778C78A1201" modified="2017-10-25" version="1">MTIPLVSFCKEKQIEIILLYPNSTHIMQPLDIAFFHPFKDIWRKTVPKWKVENNVTRLRREHCAAVINIALDSFKDEKNVIKNCFRAAGLMPFDPDAVEYNVLHKKKTKKKQNXNNVTRLRREHCAAVINIALDSFKDEKNVIKNGFRAAGLMPFDPDAVEYNVLHKKKTKKKQNEEKDNKAVSSETLKENKDPLLNLYKTIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHL8</accession>
    <name>A0A232EHL8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pacifastin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the protease inhibitor I19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004482">
        <property type="protein sequence ID" value="OXU17834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHL8"/>
    <dbReference type="STRING" id="543379.A0A232EHL8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008037">
        <property type="entry name" value="Pacifastin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036201">
        <property type="entry name" value="Pacifastin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05375">
        <property type="entry name" value="Pacifastin_I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57283">
        <property type="entry name" value="PMP inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51446">
        <property type="entry name" value="PACIFASTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013099245" description="Pacifastin domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Pacifastin" evidence="9">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Pacifastin" evidence="9">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU17834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="212" mass="23138" checksum="8B13E0919DCCF7EE" modified="2017-10-25" version="1" fragment="single">MRSFLCFVTFLALVLAVSASPIDIKRNDDFGSTGKCTPGQVFFMSCNLCKCSSDGNYAACTFMQCFDFNFEEEQRSKRSTNEVVATLSSDIPSISGYTQGDQCPSKSFYNDCNMCVCGPDDASAACTMMMCLPGETQQPSKIVPAKLNDIARIDEYSQGQACPAGEFFHDKCNVCHCSANGFSAACTLMGCPSEDTTQPRAQVTETYNWPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHX0</accession>
    <name>A0A232EHX0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acidic fibroblast growth factor intracellular-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004394">
        <property type="protein sequence ID" value="OXU17953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHX0"/>
    <dbReference type="STRING" id="543379.A0A232EHX0"/>
    <dbReference type="OrthoDB" id="16955at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008614">
        <property type="entry name" value="FIBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223:SF2">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05427">
        <property type="entry name" value="FIBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="42374" checksum="5AFA8224073E22CE" modified="2017-10-25" version="1">MLSEVDVFISNYTLVDPEVYQLWVDGYSSSDAVNILQQRGICQQTNAPVELLASDVLDHYRTYSLLEKLLHTPTKLASEQLAFQIEPQTSQMLIEMYYEFNDSVARELLGKKLTSKNRKDMEEVAEKTGVTLKSCRRQYDNVKRVFKTVEDLPGSLVTNIKQHFLLPEELAKRYAAVVFIACLRFEMNKRKLQFLTFPDLHHCANSMMTLWTYRYTGSEYFDTDLDREFLLELPECRTLLENEKHHKHLVCIKLKPMLLERIYQDMDLNFRTYSRAIIGIACNLHRTRELRFFFYELVERCIEPWRQASWSHTDLRNFLAVFTQCALDMDVLRESELRDAFERFMKVVTSCLLRMYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIF1</accession>
    <name>A0A232EIF1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004296">
        <property type="protein sequence ID" value="OXU18091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIF1"/>
    <dbReference type="OrthoDB" id="7701031at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34718">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34718:SF2">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012421004" description="Ubiquitin-like protease family profile domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31365" checksum="3BB600F4769D0D76" modified="2017-10-25" version="1">MNSKDCGIFAIAFAITLLCESKPDLVIYNIHNMRPHLLQLLVNKYIAHFPCNFTPIPINFHPRKLYDKNIIINNNCLNNEHIDYFHEMLKQLSTYKPYSTLYLQNTSKISQINENNKHIQILFQRGSTVGHFICTYYDTNTLFVYDSMNNKKLHSDVSTVIKKLHPYCFNEQRKPITFPTVQFQINATDCVGHFICTYYDTNTLFVYDSMNNKKLHSDVSTVIKKLHPYCFNEKRKPITFPTVQSQTNVTDCGVYSIAFAVTLFLGLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIS5</accession>
    <name>A0A232EIS5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
            <ecNumber evidence="7">3.5.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartylglucosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycosylasparaginase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_014327</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15947"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58080"/>
            <dbReference type="EC" id="3.5.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.26" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01004159">
        <property type="protein sequence ID" value="OXU18269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIS5"/>
    <dbReference type="STRING" id="543379.A0A232EIS5"/>
    <dbReference type="OrthoDB" id="188713at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127323" description="N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase" evidence="14">
        <location>
            <begin position="25"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="13">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU18269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="345" mass="37209" checksum="29E4B1BD5AE0B2D4" modified="2017-10-25" version="1">MAQFNLSMNLLILNVYMILPCTLAVDKFVPLVVTTWDYQNATQIAWNTIYNNKGSAIDAIEDGCNFCEETQCRGTVGFGGSPDENGETTLDAMLMDGTTMDVGGIGGLRNVKNAISVARHVLENTAHSLIVGNLATEFAIKMGFSNVSLQTAKSRSMWKKWQENHCQPNFWKNVVPNPTTTCGPYQPKKKTKYPQKFMHSNEDNHDTIGMIAIDTKGHIAAGTSTNGARNKIPGRVGDSPIAGAGAYADEEVGAAAATGDGDIMMRFLPSFLAVELMRQGSSPTSAAEAAIKRIVKHYPNFSGAVIALNKEGQFGAACNGFKGFPFYASNVQLGKPTIFYIPCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIW4</accession>
    <name>A0A232EIW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004153">
        <property type="protein sequence ID" value="OXU18285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="118" mass="14077" checksum="814E9CDB9BC3EE8D" modified="2017-10-25" version="1" fragment="single">VKHYYLQALAFVSFQQFLLFVSFQAFNLFNYLNCRFFFFFCLCSVASISLNLGKKGLHARLLFSLFLRRSRLSRRKIIVVIYVYVKDLEIDKYHPSLKCLLHLLLKLHKKTFKKSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIW9</accession>
    <name>A0A232EIW9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004165">
        <property type="protein sequence ID" value="OXU18258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIW9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7606" checksum="430B13C8300C1A1E" modified="2017-10-25" version="1">MVDHFNLLWEICQIYGWIQKNVLDKSCRGHRGSTFGNNNFELEFVFEGYFKVKIIFLNRKTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ05</accession>
    <name>A0A232EJ05_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004150">
        <property type="protein sequence ID" value="OXU18288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ05"/>
    <dbReference type="STRING" id="543379.A0A232EJ05"/>
    <dbReference type="OrthoDB" id="7615632at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26367" checksum="86E0FF826BE8670C" modified="2017-10-25" version="1">MIASDVIEKVTSPYCSPIVLPKKKDGRYRFCIDYRRLNDITIDAAQPVPHIADALKDLGDASIFTSIDLKSGQHSTSCQLAGENTELTMTGETDLKIEIQGAIFDLNARVSPDIRHPLVLGLPWLKKDGCVVDLTQDVVYLGQQIRFTAPLTHCAPREQLAIVNVDELYHGLTGSDLTRLLQLLKEHSVVFIQDGQKLPRTRTVKHVINVATEKPFKLPLHRESETKQPIERRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJI0</accession>
    <name>A0A232EJI0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003996">
        <property type="protein sequence ID" value="OXU18516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJI0"/>
    <dbReference type="STRING" id="543379.A0A232EJI0"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="9118" checksum="546E805B8B7E5941" modified="2017-10-25" version="1">MSAPTLDHVDSVDEDLKVESIYKTPPVKSIEQILEADKEDERLRKYKKTQLGESKGGGFVVKPNDLRQIIVKKAWTMCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK95</accession>
    <name>A0A232EK95_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_008672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003839">
        <property type="protein sequence ID" value="OXU18779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK95"/>
    <dbReference type="OrthoDB" id="7682993at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="206" mass="23426" checksum="36664D33119A50A7" modified="2017-10-25" version="1">MSAESTIPKNNRDSYTVTFRNCQGLSNAEIIEIFSKYGRVVCMGITGGETGYRFVHFSSEEEAMRAVLHGNDYASKLRPHKSKPLDMGAQRAVGWIKKEPRWEEPLKVDKKIVRKAAEVIVRNLPPQFGPANLLKMFQKYGPIAMTPIMVVQKTGMRFCHVYFRSQKDVDNFQRDFNKHLIENKNPMVVPPSTPMKTNITNSCDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKP4</accession>
    <name>A0A232EKP4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_000783</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003734">
        <property type="protein sequence ID" value="OXU18927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EKP4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012375821" evidence="11">
        <location>
            <begin position="30"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="935"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="96"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="405"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="935"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1215"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU18927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1506" mass="169126" checksum="986D0B9DB00ECEF2" modified="2017-10-25" version="1">MAQQRKPSPRLSANIFSGLFFCWLKPLFCQGKSRDLTSDDLHDALPADVSEQLGGRLEKYWKNEVENARQSDKKPKLVNAIRKAFGWSYFYYAGHMLVLNCLRVLQPFTLGLLIEYFEPGSRTAKSHAYVYASSLVLLTFLHSLLKHHIDLATLEIGMRLRIACSSLIYRKVVRLSNSSVNANTGGRLINLLSNDVARFDPLFMYLHYIWITPLQGTVLAYLIWRNVQLASLAGVLLMALETIPVQVYIGKITSRLRGKIATRTDERVRLMGEIINGIHVIKMYTWEKPFENLVSLARRYEIDVITWMSYLRGVNISSNAFVDRTCLYFTIMAYVLAGNVISANKVFSMVQYFTILQHLLVYNYPRAIFNVAEAQVSVKRIEKFLMLQEIKIKAPLLSIEDNGSISLKSVTASWSPNSIVNTLHDITMYITPKKLHAIVGPIGSGKTSLLQLILGELRPSTGDIKINGTISYASQRPWLFPGTIRENVLFDQSYDEERYQQVIRVCSLERDLEQLAQADRTQVGERGTNLSGGQCTRINLARAVYRDADIYILDDPLSAVDANVCKCLFNDCINGYLKDKTRIFVTHQVQCLKEADTIFLLNNGKIDFRGKFAEFSKRDLQFLNVCTEEEEEEERNNEELNENSRETIENINNVHNNKNQDNIIPKDAKDDDNAEKEPQETEELIAKGKMQTSIFTRYFHSGNSYFFLVLIILLFVLAQTIRSGSDYFLAYWTRQEEYRWNTVEGTTSNFTADRSVLNFTESKSSTFVPSMTESSVLTIPTTESVLDTTLRDLISSTTTILSNTIQNISTTTESISGTVQDLITTVTENPFFSTSQSSVANTTVSSTTTVRNLATNTTDNALLKTSMIANSTASTPSTQTYLSVNTTTSSSFVPQNLILSVTEKLMSNLNSTLESKPEVSTSTELSNYLSVDKALIIYGCILLGCVITAVCKSLLFYKICMNSSTNIHNQMFSCVLRAPMRFFDKQTSGQILNRFSKDTGAMDEILPATMYESIEVFSIILGVLIQVLIINWYSVLPMIFTGFLFWKIRTFYVPTAYGIKRLEGAAKSPVLSHLTASLDGLVTIRASRSQTMVCRRFDARQDEHTRAHFLNIAVASAFGLWLDLVTVILVGFVTIGCLLADETKTFAGSVGLAITQILMLCGMLQRGIRQTAETVTQMTSVERILQFTQLEQEETRPEASVSIKPPSGWPSRGKIEFKKFCLRYGRNEEPVLRNVNLIIEPGTKIGIVGRTGAGKSSLISALFRLARTEGQILIDEFDTNNLGLHELRKRIAIIPQEPVLFSTSLRDNLDPFHEFEDTSLWAALEDVELHKAFVPLDHPIECGGRNLSAGQRQLLCLARAIVKKTRILVLDEATANVDPATDALIRKTIRSKFQECTVLTVAHRLESVIDSDKILVVENGEIVEFDHPHLLLQIENGCFAKMVRQSGDAMHAEHLRKVSEEAYNIIRLNNQVSTTEGDVADERTNINGVVKSNESADATENSSEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKQ6</accession>
    <name>A0A232EKQ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003753">
        <property type="protein sequence ID" value="OXU18901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKQ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="222" mass="26699" checksum="21F490EE5B96601D" modified="2017-10-25" version="1">MKLPLEPEQEKLDGEIRRASFKFYFDLDINFCSPKTLYINMAQFRWTSICENCYNPNNIPYPEARVSCTDWHHHGDDLDFMIYYLPLEPEQEEIDGEIPRASFKFCFDLDINFCMRQLEYKNIIYINMAQFRWTSICENCYNPNNIPYPEAIISCTNWHHHGDDIDFMNCYDNSPVQQQPTIHNNHQNQIRKQENKYQLNISIRTNYKPFVSSYHIWNLGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKX2</accession>
    <name>A0A232EKX2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003694">
        <property type="protein sequence ID" value="OXU18995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKX2"/>
    <dbReference type="OrthoDB" id="7684380at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68501" checksum="9DC3BB1E83FF3B1C" modified="2017-10-25" version="1">MYAYVKFIDGANQGHKKIVKAESINHKFNEDLKFNSRGTYTITYDGSEQRAQIIFLKRTQNEINKLVQSNKRIKSKLDQDNNVSKSDQNDLQKSITFDEGTMKSITFDEGTMVNKRQEVDDLTMAQDSQISIAKNAADQSTDGKNNKVTAKDDVLKKTSNNSRLKSGNNGDVMLSEAIKQKLDTAVIDESYPTEEATDNIKNKPNIKSVEPVHMHFACKRKQQEFLKTIKEKEEKIQKLKDENEKKQKQLHDLKKENTRLKNKNNGLIDEREKANKIALTKETLIEQLQRVIIEKFFEHNTIKDQLKDFEKDLEIDDTKNYLPVGSHRQSDNTIHIGRNQRLSAGIYSTVMRSKKPSACVAHALLAVFGESTLLRSTLTGNISNRTKGIMKGKTGKRGKKGKADKKEKDAEDEDNVSEVEDDPQIETNKENKNEIIPKYEKLDGVKLAACEDLFIHYVRTIYGKKKGVTDANIQVELSSFNEYVSRQISYLKRERGKKKIVEKDVDETIFSVEEPDKKTENTYANLIMLEEAASSSMSNSLSLLSTQAMDPLAIEYQEKSAADSKDRALDDTQDVMDDMSSDYSSVHLDDTVKDDSVSDTEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM75</accession>
    <name>A0A232EM75_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="3">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_017049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01003441">
        <property type="protein sequence ID" value="OXU19412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM75"/>
    <dbReference type="STRING" id="543379.A0A232EM75"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000052">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="239" mass="27137" checksum="7A890DFC5F20CB90" modified="2017-10-25" version="1">MCGIFAYLNYLTPKTRKEILELLVGGLKRLEYRGYDSAGVALDSPDGKDIAIIKKQGKVKALEEEIFLHSTLDFDTNIESHVGIAHTRWATHGVPSEVNSHPQRSDIEHSFVVVHNGIITNYKDIKILLQNRGYSFESETDTEIIAKLIHHIWVQHPTYSFRELVEQVVQQLEGAFALCFKSKHFPDECVSTRRGSPLLVGIKTKTRLATDHVPILYGKDAVRQDPEEKEPIEDPRSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM97</accession>
    <name>A0A232EM97_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003397">
        <property type="protein sequence ID" value="OXU19480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM97"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57346" checksum="0E566FE107E95D1B" modified="2017-10-25" version="1">MRIRTNSTTNSTRINSKPNDAHTDSTCNAQLGVSIRGNNNPQPCRTPFNVRGENKPRDVAKSVASWYFKFSGDGEGLSIDQFLSRVQECDALRVNQEKWLTWTQFETDMRNQFKSEGYHKEFEDKIRERKQKPNETMNNYLNAMLAMFKKSLEPWIDQNKINRIYNNMRGEFFTLLRPFKNETLEIFLNQARSIGQVYETGKCGKEKSANAAASKPNVDKTYNNGVTTNTQRKPETSINTIEVLTVDEVTKFTSKELTKFRESIKATVANEISPKSSQNSNRPNNNSNQQGDGQNSSQNNSQISGNNNSRGNKRETTTLAKKSKVSKIRKGKLNNDDTEQPSINSQEPLSVPDAEKPVEHPRYWLKIRVGNTEFKALVDLRGSKYNNRKNAVMANGYPEPIDGEMTVPLEIAGVSKRAQILVIPGIPTDFILGIDLVRLFGMKIDARRDTFKLPDRKDKKEIAFEVWSIDTCDRLINVASCGLSQISASEQQQINNLIDELLLRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMQ2</accession>
    <name>A0A232EMQ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003317">
        <property type="protein sequence ID" value="OXU19634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMQ2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="12971" checksum="56A54A0115312EBE" modified="2017-10-25" version="1">MKIAQNTLRYPWVSSLLYQWPIKYQRTDTAKRLLPHPAFCSSTEVANFLLSTGACISLKNAAGNIPLHTAFRLRYNLREVGNPALLYIPENPVGDEGYPPFHIACQIGDLAAVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENP1</accession>
    <name>A0A232ENP1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01003103">
        <property type="protein sequence ID" value="OXU19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENP1"/>
    <dbReference type="STRING" id="543379.A0A232ENP1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="409" mass="46861" checksum="37F5F9DC7FFC2954" modified="2017-10-25" version="1">MYNFITNLFIDPVSSNICIYIMKRHTSTLTFSLIVSVMTYASAEELKLKTLSVIFRHGDRAPIFLTPTDPNREKDIYPLELGTLNNQGKLREYNLGHLLRQRYNDFLGPYYETTDVFAMSTDVDRTKMSLLLVLAGLYPPVGKQIWNKELNWQPVSSYAYVPDKMDPILGYLIHCPAYIEEYIRVQNSPEFQTKLSKYDGLMKNLSILTGASMTNSLDVYALYIDLGAELSSNLQLPAWAKDYWPEGPMLEESLLEYELQNYNRKLKKYNGGATISKILATVNSENPKKLNLYSAHENNVAGLLYALDVWDHTIPNFSSAILFEHHENSSQKFIKTIYYKGIPAVFDELTIPGCDTLCPLEDFHKIVADLISENPIEACYGPPDNSTLLPKDMQPVQWIYDQMMFFYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENX1</accession>
    <name>A0A232ENX1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003067">
        <property type="protein sequence ID" value="OXU20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENX1"/>
    <dbReference type="STRING" id="543379.A0A232ENX1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="88"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="241" mass="27916" checksum="B78C98037A5C127C" modified="2017-10-25" version="1" fragment="single">MFCYHCPSGLPAPRLPPSLEYPFAPTHPYQIDKELQITISADKPFELAYESSNPSTDIRKELPRSPNASYSAYHPALHGVGEDSFVRRKQRRNRTTFTLQQLEELESAFVQTHYPDVFTREDLAMKINLTEARVQEAESRVTRCRMTPGELSAAGSRHYERMLSPTKRVEESRDFNKVWFQNRRAKWRKSQRLKEEQRKREGSASADSSNPSSQQQQQQQQQQQQQQSEPEESSGPNNQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPA2</accession>
    <name>A0A232EPA2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002979">
        <property type="protein sequence ID" value="OXU20190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPA2"/>
    <dbReference type="STRING" id="543379.A0A232EPA2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF226">
        <property type="entry name" value="RE28171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU20190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="615" mass="68965" checksum="C4CC022349E2DA4B" modified="2017-10-25" version="1">MSLAGPAAFVGWSLIPLLGIGFTMFRYSSIDPESHPINQRQLLRTYDFIVVGGGSAGAVLANRLSEIPDWKVLLIEAGGDENEVSDVPALTGYMQLSEFDWMYQTAPPTNSAYCLAMVGDRCNWPRGKVLGGSSVLNAMVYVRGNRHDYDNWERMGNPGWGYDDVLPYFLKSEDNRNPYLTRTPYHGTGGYLTVQETPWRTPLSIAFLQAGSELGYTNRDINGANQTGFMLTQATIRRGSRCSTAKAFLRPVRNRANLHIAMNAQALKLTFNENKRATGVEFMRDGRKQHVRVRREVIMSAGAIGSPQLLMLSGIGPREHLEDLGIPVLSDLRVGDHLQDHVGLGGLTFLVNEPITFKKDRFQTPAVMLEYVLNERGPMTTQGVEGVAFVNTRYADPSGDFPDMQFHFAPSSISSDGGDQIRKILALRDSVYNTMYKPIQNAEAWSILPLLLRPKSSGWIRLKSRNPMIYPEIVPNYFTHKEDMDVLVDGIRIAMEVSNSSAFQRFGSRPLTIQMPGCQKHPFDTYEYWECAIRHFTFTIYHPTGTCKMGPRSDRTAVVDSRLRVYGVKGLRVVDASIMPEIVSGNPNAPVIMIAEKASDMIKEDWRMLRREAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQM2</accession>
    <name>A0A232EQM2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002741">
        <property type="protein sequence ID" value="OXU20650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQM2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="221" mass="25191" checksum="923E3EC73BEE1882" modified="2017-10-25" version="1">MDLKSYFTTSEEIGEWEDHDPTTNIVGYIDSITAPSPSGLKQELFFKFTVSNGSNKVYVLVININAAYCRVTDRRVTKKTEEKNLVPFDLIIKENTTVTFMGYYLLTNAALDELHRVTFDDIHTVQGLIEISGYIRTKFSLIHNRSGVMNYGIGAITNGTKKLLFKSNNSESLSSKLEIIFSCYHFCNDMDDIQFDSDNEAMLPELVQRGCRPVKRIRTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERC9</accession>
    <name>A0A232ERC9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002620">
        <property type="protein sequence ID" value="OXU20923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERC9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="19475" checksum="D02E0926E44E6C48" modified="2017-10-25" version="1" fragment="single">LGAEHLQRLDASTRVNPGSKQQRALHQRTSCNPWFISVDWKLGIGQSIQDMQDYHNREKRDRLRNRRRSRPLQCQPPHLWLLTRTSASSTATICTLQDLIRLFLRNESTMNDKPETAIRQPEHENEFATKRLIYIIKTFTPQMIKLAQSGSREVVYLSRSFLLNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERV0</accession>
    <name>A0A232ERV0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002555">
        <property type="protein sequence ID" value="OXU21061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERV0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="30" mass="3750" checksum="F7266C47592CFD76" modified="2017-10-25" version="1">MGNISDLWLDTEKCFRQKLWRSKGVNFWYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESE5</accession>
    <name>A0A232ESE5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002461">
        <property type="protein sequence ID" value="OXU21237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESE5"/>
    <dbReference type="STRING" id="543379.A0A232ESE5"/>
    <dbReference type="OrthoDB" id="7555100at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="319" mass="37387" checksum="7AA04D22D57DE0F3" modified="2017-10-25" version="1">MEQSSIELDTHEQTHNCEVIRLQEEKLNLQAGNNGLKLVCDFLKIENNDLKEQNEEFKNKNEELQNKCSTLELEHKIMKKDILKLNKKLHYVYGMPEIELIRTIITDEALIYVAGYVAYRFRSKYSMLGTPTREIPNTDPTHWICHISRGSLIYPLDELLSTYVYEMPENELIRTIITDEALIYVAGYVAYRFRSKYPMLGTPTREIPNTDPTHWICHISRGSLIYPLDELLSSARILEKDFKSFHKDSLSDTNLIFVKVASLVKRKIDDQFHIPDEAFLCLVRTRTYIRLRELNKIRKDSYGKIRIAERSAKAIKFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESM2</accession>
    <name>A0A232ESM2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_008435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002396">
        <property type="protein sequence ID" value="OXU21359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESM2"/>
    <dbReference type="STRING" id="543379.A0A232ESM2"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="502" mass="56844" checksum="8DB72BAD48BFC711" modified="2017-10-25" version="1">MSGEKITLLKREPGALGTRMWSLYGKLYLRHFNELDHELNARLNRAYRPASKYMSMFTSPLVTVIAKNVAFIFGSIFAVFLILTFYDEDFLTVEHVFMIMTVSGSVAAICRSLVPDENLVWCPESLLTAVLAHTHYRPDSWQGQAHTQTTRTQVAQLFQYRAVHLLEELMSPLLTPYILCFHLRYKALDIVDFYRNFTIEVTGVGDICSFAQMDVRKHGNPMWQTLPQSPINKEPERPEYSDLQIGDINKYIPLCSNQYTQAEDGKTELSLIHFTLTNPEWKPPSHAENFVAALRERAKREATAGQLENNPLYASLSSVSSLGPEYNDIVSNILRSPIMTQVSMLNTNYNYTHQPTGMSLHTSINGQNVCSTSGNTAIRRNVNRAEGPLHIGEKGLLYSLQQVIGDSYHSLETSAFSSGKQEMHTIQHTVPLELTAVDMSLSTLYLHEIHHRQIQRQSQKETVNKTIWQRDAFQDLAALPEAGQERAPLLAHPNSSLRNKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESZ5</accession>
    <name>A0A232ESZ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002358">
        <property type="protein sequence ID" value="OXU21474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESZ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="122" mass="13272" checksum="C3B543B0000F2556" modified="2017-10-25" version="1">MLKPEGDDEQLLVLHRARVALMSLLCVIRANATNVAGTTILSAIKEGGKTIQVCKNCLVVANKTPRSTSTFSPSSRSDSPLPQQQRRYSKPASAPPSRSSSPSRKEDPMLNKILDNLNKLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET86</accession>
    <name>A0A232ET86_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002308">
        <property type="protein sequence ID" value="OXU21568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET86"/>
    <dbReference type="STRING" id="543379.A0A232ET86"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="162" mass="18550" checksum="1CF7EAB3255604D8" modified="2017-10-25" version="1">MNWKNLCDLDDLVKILLVDQFQLVRKFKNRVLVFENFFKLYLEFFYPASQVQIVPCTRYSLDKKQGVTVIAKKGLEAGTILHCVFGLYKTISPDEEKSLDNLGLNFSILTTSSSSNSKVLLGSIAFINHDCDPNAEYISKSRERVSLRILIIASHYYFVSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETI4</accession>
    <name>A0A232ETI4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002278">
        <property type="protein sequence ID" value="OXU21644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETI4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="4">
        <location>
            <begin position="78"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="5">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU21644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37663" checksum="7C43AADFA4502F12" modified="2017-10-25" version="1">MLKPEGDDEQLLVPTSCKSCTDVIAMRNPLKCDKCGWHFHPKCMPIQAIRKEKQQNKMKNQLPESKSSLEKRMTAIEKSLEPLKEIPALINRVTVVEEDVAALRAEQEEIKAKLEQLLMKITLKNKWKSLVAKFRSESRLEAICKSGDAAADSYESSWTHYKSLKFLSDIVQPAGSEGNLSQLFFKEEVLGSDYEENITENENLAPNRQAYQTSAQRNCIMVNKAVNEKIKRKAIDDDMLDMSDADLLFFRTLAYHVKKIDNDKKLQFRNEINSVVQKYVYGSSIQLSLERTAERRARRRQRREATEDDNGMIKTEPGYGHVHPGHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV58</accession>
    <name>A0A232EV58_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small G protein signaling modulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RUN and TBC1 domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016879</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002052">
        <property type="protein sequence ID" value="OXU22236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV58"/>
    <dbReference type="STRING" id="543379.A0A232EV58"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17688">
        <property type="entry name" value="RUN_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11813">
        <property type="entry name" value="SH3_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000015">
        <property type="entry name" value="Small G protein signaling modulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000012">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000013">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000016">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000115">
        <property type="entry name" value="Small G protein signaling modulator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035833">
        <property type="entry name" value="SGSM3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="8">
        <location>
            <begin position="157"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="527"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="602"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="794" mass="90394" checksum="4AB945AC571B14F8" modified="2017-10-25" version="1">MEIAKSLFNVRDHEGYVGKEDHDKKLETAVSDDEYDIDGSGLGTEVLSPAPGGPFSALTPSMWPQDILAKLNQPNDDPNSQPEYRFDEFGFKVDEEDGLEQSAKKLLNVPFVEDPQHRQWVALLEFSHNKEVSELSWQHVDNRLPRTDKLREMVRKGIPHSLRPQIWMRMSGALQKKIASETTYKDIVKASSSDALMTSKQIEKDLLRTMPANACFSNLHSTGIPRLRRVMRGLAWLYPDIGYCQGTGTIAASLLLLLEEEDAFWMMATIVEDLLPASYYSSTLIGIQADQRVLRTLVANFLPDMDQALVQHDIELSLISLNWFLTLFASVVHMKILLRLWDLFLSDGSIVLFQVTLGMLKIKETELKALENSAQIFNALSDIPGDIIDVDQLLEVSLEVSGSLTDALVETHRRRHLAYLMADQGGLVGNPDAVPNLPKQHLNRRQVKRSKSMLQSFLFGDDESGDDVKCKNIRQTEILVDLREAVLQVARHFINLDPKLSNTSLTADYSMESHAKDHDNYINVSRTRKRRAKALLDFERHDDDELGFRKNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERSKQYTCAGDDAVSEAVTDLVRGGLCPAIKSVLEHGMKRPSFLGGPCHPWLFIEEASNREVEKDFNSVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQSVNLTHDNAHAQMDVKLRSLICLGLNEQVLHLWLEVLCSCVEVVQKWYYPWSFVNSPGWVQIKCELRTLGQFAFNLNPDWELPPKKEQSQPLKDGVRDMLVKHHLFSWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVN6</accession>
    <name>A0A232EVN6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-binding domain-containing protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diphthamide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein DPH6 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_016462</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Diphthine--ammonia ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001974">
        <property type="protein sequence ID" value="OXU22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVN6"/>
    <dbReference type="STRING" id="543379.A0A232EVN6"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000010">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000069">
        <property type="entry name" value="diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="720" mass="81200" checksum="6D7CAD8557942ECA" modified="2017-10-25" version="1">MKVVALISGGKDSCFNMMQCIAAGHDIVALANLYPVGKGINELDSYMFQTVGHQGVEFMGEAMGLPLYREPTFGKSKMQEKHYLPTEDDEVEDLYRLLKKVKDREDIQAVASGAILSDYQRIRVENVCSRLGLVSLSYLWRRDQEQLLKEMIECSVNAVIIKVASLGLEPRHLGKSISEMEPHLAKMKEKYGLNVCGEGGEYETFTLDCPLYIKSIVIDEYESVVHSNDEIAPVGYLNFKKIHLQNKNSGIENLTLQERLKNIAVKTPLDYISEIVGPDLQDGCNLSDDENDEQEKDNKDLQTTNSGQLNPPSPMETAYEEEEYPNVPAVNKNQTGWYWFGSIVGKNPEPKLAMAEALDSLIDLVIKENLEITDLVAVTMFLKDLSVYADINEVYVSKLAKVNPPVRVCTEIPINFHVVLDALAYKKLEEDERSDKKVHKRHTMHVQSISHWAPANIGPYSQAVRNNNGSNYCFKQVGDIISVAGQIPLVPGNMAILDSNIKRQCRLTLRHINRIVKAMDSNTELRHIVQGICFLTHPSFIPAARKEWEKRTNNAIVDYVVVSSLPRGAQVEWCVWAHRDNNRFEYEETGKCVGNFKVAIRRRWNYENNVSAIVCYLSTGSSNSTGNLTTETNISSTDFTMPELVEAFEYLLCKLTKGSQAENPSCNLRIFYKVGSLSGPSFIQQALRHFDSRNLVTTIIPTRHLHNFSTFLSVCGIRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVY1</accession>
    <name>A0A232EVY1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001933">
        <property type="protein sequence ID" value="OXU22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVY1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="83" mass="9568" checksum="D68F19925D7ACC66" modified="2017-10-25" version="1">MDRPICSVKCIFDIQSNVCLVLLCSFVCVCVCVCRNISGTTRSISIKFDIHVYFWIPNSRKAVIFYFSNNVSFCGQFLIFEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW02</accession>
    <name>A0A232EW02_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001928">
        <property type="protein sequence ID" value="OXU22532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW02"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="10351" checksum="A737FE121F51D58A" modified="2017-10-25" version="1">MEVAGETEGEKEGEQCKGKYCSPDLECDDEEISNRRPAARRESNDDEDDAAARKERFDEAVFTLATIVAVLGIYGCLVYALSSPPAANVSDYAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWZ5</accession>
    <name>A0A232EWZ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001803">
        <property type="protein sequence ID" value="OXU22874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWZ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="111" mass="12382" checksum="1337E262885D4B9A" modified="2017-10-25" version="1">MVEEIATRLLSENEKGERKSLGGHVYQELLDPVAILSLINPEIDERFRERLMKSTTKLLTATGHIHSVLGELEVILDIGGKEQAISFNAAPSLEQPMILGMNFCKKFDCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX44</accession>
    <name>A0A232EX44_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001775">
        <property type="protein sequence ID" value="OXU22956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX44"/>
    <dbReference type="STRING" id="543379.A0A232EX44"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000022">
        <property type="entry name" value="protein deglycase DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0558">Oxidation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="4">
        <location>
            <begin position="38"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU22956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="221" mass="23498" checksum="F7296F8BD52F066A" modified="2017-10-25" version="1">MSATALLLRTFAASANCLFRENLRRSSTALFSTMAKKTAVCLLAEGAEEMEAIVTVDILRRAGVSVTVASITDKECIKCSRDVKICTDAKIGDIEGQKYDAVILPGGVGWKNLAASAKVGIILKAQESESKVIAAICAAPNVLKAHGIAKGKKITSYPSVKNDLTSDYSYIDDQIVVTDGNLITSKGPATAYAFGLAIVEKLVDKETAQKVADGLLYKDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXC0</accession>
    <name>A0A232EXC0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001773">
        <property type="protein sequence ID" value="OXU22958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXC0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="9065" checksum="7B77328216BEC2C3" modified="2017-10-25" version="1">MVLFYTAQLAPERSVGTKRRVKLNHLSQEYPQTAKICKSCLFVTKVVLICTMRLAHERSKCDKHGAKKDYFSHRLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXF2</accession>
    <name>A0A232EXF2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001762">
        <property type="protein sequence ID" value="OXU22989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXF2"/>
    <dbReference type="STRING" id="543379.A0A232EXF2"/>
    <dbReference type="OrthoDB" id="9986793at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="238" mass="28051" checksum="2B37A0BD56144CDA" modified="2017-10-25" version="1">MTSVSSHGFHRTGFLMRSRNNPLHRQRQRNRLQNNNDPRLLAVLAMVHQNLRISTRQIERELGVPRNTAHRFKMANNTPNEVVDILITLGECGRNYRLTARTNVERFPNRRHSNARQISLNWEVGILKRELGVPRSTAHRWLQSVNHHPYDITLVQELSEAYYVLRVQFCRWACEMLDQNPDFSWNVYFSDEATFISNGCLNRHNCHYWSPENPHWYSEVLNQHRGASTYGLAFVMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXG7</accession>
    <name>A0A232EXG7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001743">
        <property type="protein sequence ID" value="OXU23052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXG7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7470" checksum="7700A460E8BFBB16" modified="2017-10-25" version="1" fragment="single">MVETKVVGYRRGNPMVTLDLTLNAFFKEPHSFIAGMERAVNFTFRMVCSVAALKVISMSCSQNETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXK7</accession>
    <name>A0A232EXK7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001751">
        <property type="protein sequence ID" value="OXU23030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EXK7"/>
    <dbReference type="OrthoDB" id="10053234at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1574"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1353"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1370"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1426"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1583"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1755" mass="197126" checksum="3A5CBE773771070C" modified="2017-10-25" version="1">MDSKNVSQPSSQDCNVQSPALQTYHTPNEGHIYYVIMERLVTKLNDIEHELKCAWRILDILNQECIKMWERLEKLEGFLFEQQNVITQLVEYHSTENNQEESNVVNETIIGSVGELDAIAESLGAAIGIEETSVLREKLAKKELTKKQEFIQESSKSISPVTDNQRNIRYLEALETLDEEIAVPDEAFYRSLNNAYREDLICGDTSRPASQLGMIWEEAEDVEDLNCKKDIENSKQSKEQIQLDSTILKQTSCTLTKKESEKQVEEETDVQEDEGEVFSAEDYKTYRGDSPCVSEHDLAQLSRLSLIDEASLDKLHELNRLTSKLQKDSQNLIELHSKLTESPKKLIFSEGEAKTADEMSNTDEQLRKMYVETDVDNWTYSKSPGSTGRSISRVSTDSGLTTDGDITTRSISPRLNSASKSNLDFNPLVYTQPKASYATALIEISPESVIKLPIDVGNFAKGYAENKELTDLMVESLGTINCVSPTRSVESLHDIHDIRAEKDEYIGSVMRLNLLNKMQYNENRSPESQSPMSPPPPAPQDLNENLFRKSKEQPECINKSSQSSGFSKNIDINYDQNKFNSRAQHSPKSPRLSPKQVAKPTNSIVTAKSDSGLSSMSGWSSIDKSPCSPKNLVSKILSPFSSDNAKPTVILNTETTKIENPLMSFSDIKIVNVDPLYDTPEGLDSLCQREPLITDHLYDSIVNHLPLAQTVVNSVMIDDFDSVPPPAPAKRSTLSPKSSHLHTLSKSIDVITIATTKDFFCRNVQPAIYSVAGSNKSQAITSVYTSGSGAYEAKIAPTENVSSSEDLRTIYQDRNNTVSHNVISANCDLLNYVKKSSKTALYVGEITNNDGSKTANYKTMFPTGNITDALSYYPTSTNLSGTEIIDNSWHSTCNENLLSDPTSLNLKSPSLEYNHHQNIYTDRRTVLPSYQTVAFHTYANQGFIQAYQQQCQLFNQRLSSFDNPQLADPYQKQCQKEHQHFTDQELQKTQINKLQQEEFYDASNVIVSQSGYISISANIKDLEPESLKSSKKIRRGSSLKNAMSSMSNWLPDLYLYKRNRSQSLPGGIKREELNEPPNSASQRVLSETISVIHRPGGPSVRKKKKHILVSTVSGILQKAKRRSHHTQSISDPEQSETEWSSGKQSGLSEDEESTISEVNQEISVFAKVRVNTCNKKQLKRVTAQQHSEDDEQKEESLKQQCLQQQEALQQQNHHQEQLQKNVIKEEWLSEMETERKSDPNEEEPVEQIIDFEDETSGNSTISGSGGSSIFPTVGDIKKATNSSDETLNDKFPKLPPVTLIGGSSMEFAVSRALGKYRQRQSFALPDDQFDLLNNDQKLYNSAIQSSFDYQEDLSEKSDKSEKESKLPELVTSTIEEVQPAESSPSASSTRGHSQSGSRFFPRHQQSLEIPWAGSRSGDGDEDNRSTHSYRSTSRVSSRRQSTEDSIDSEDEWYCYELRKLEELERQSETKKETDINFTFVEESEKIETYHPNEEVKEKMSFVLEELKLKTNLLAVSTDDDVKIELVTTKINATMDIGERYHYERPAPKKKCAEPIETVFARVTDYHTWAHEENAKRERRFTTSEENSSGDTSGPDSPVHSVEEDDELPKDINEYHSRRSSSGSMLRHYEKIPHSSDSFSREGSVSVPPSEISVSIPGAWDSESIFIESERDGSASTEAGIQSLPKIKVDTSSYTSCDDNAARDGQFSPGLPGSKWKLLKALKERKAEEKLKEIEEANKEANEISQGITPVSIKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXL0</accession>
    <name>A0A232EXL0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001712">
        <property type="protein sequence ID" value="OXU23154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXL0"/>
    <dbReference type="OrthoDB" id="9988974at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="381" mass="42861" checksum="01B8ED54736ACE5F" modified="2017-10-25" version="1">MENRAYEDEANKAAHHQHYHHYQQQQQQLLHKHQQHPQFNHSMHSHPQQHQQQHHPHHHPDDEFSHDPPQISEGSHHLHQNHLVQPRFDTYRGLEMPQHTADCHVYEDIVPPYGLALEPGGGGGGGFQRNLTLPLRRTSQSCESIETNPQSSSVRVTNRERTRGSVIDRLTRDDRNRDSGHDDSIVSGTSSNSNTDRPQRRRRKKDCKHCKIKAIARSAEEAKQRDEHAVYEERSAELRAIFGLPDVGLCRLAPGCLSAGVVYAIGCNGTDCSNGIMNGGAAGDGLQQSSTMPRFAHVQPQPQPQQQQQQDGTTTGSLLCDDKALITPPPGSKGSNRTAGMKVNSIYAQEHWHAAKDPRIFLNDPKDQNLPFQLMHLLKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXM1</accession>
    <name>A0A232EXM1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001745">
        <property type="protein sequence ID" value="OXU23050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EXM1"/>
    <dbReference type="OrthoDB" id="7546849at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="241"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="432"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU23050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65770" checksum="FA20344DB97A04DB" modified="2017-10-25" version="1" fragment="single">GFLKAGIELGYPVVDYNAYNQSVGFSYIQSTMKNGIRMSTNRAYLYPANNRKNLFVTKLSHVDRILINPETKRAYGVEFTKFGKKIRAMARKEIILSAGVVGSAQLLMLSGIGPSKHLKEMKIDVVQDAPVGENLMDHIAYGGLVFLLDQPIGILTKDMVNFAKPYLSDYLIRKTGPFTIPGGCEALAFIDVDKPTKLDVYPNIELLFIGASIVSDSVIHXDEHEQSLSVSREQQEEPLSHVDRILINPETKRAYGVEFTKLGKKIRAIARKEIILSAGAVGSAQLLMLSGIGPSKHLKEMKIDVVQDAPVGENLMDHIAYGGLVFLVDQPVGIVTEDMVNFAKPYLTDYLIRKTGPFTIPGGCEALAFIDVDKPTKLDVFPNIELLFIGASIVSDSVIHKNMGISNKYWNQMYSNISGHYSWTIFPMLMRPKSRGKILLRSNDPNEKPKIFAGYLQDPEDVRIMVKGIRSALEVSRTRAMRKFKSQFHEVPVPGCEHRQYDSDEYWECALRTFTITIYHQSGTCKMAPDNDPTGVVNPRLQVKGIQGLRVADASIMPMIVTGHTNIPVIMIGEKLADIVKEDWGYKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY04</accession>
    <name>A0A232EY04_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Proteasome 26S subunit ATPase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001637">
        <property type="protein sequence ID" value="OXU23354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY04"/>
    <dbReference type="SMR" id="A0A232EY04"/>
    <dbReference type="STRING" id="543379.A0A232EY04"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="434" mass="48439" checksum="5FC2A6AE4958572A" modified="2017-10-25" version="1">MPDHLGDDMRKVKGDEEKEEKDIKPLDEGDIALLKTYGQGQYTKSIKAVEEDIQTIIKQVNELTGIKESDTGLAPPALWDLAADKQTLQHEQPLQVARCTKIINADSDDPKYIINVKQFAKFVVDLADSVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPEKFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARSKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFGLPDLEGRTHIFKIHARPMSIERDIRFELLARLCPNSTGAEIHSVCTEAGMFAIRARRKVATEKDFLEAVTKVIKSYAKFSATPKYMAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYD0</accession>
    <name>A0A232EYD0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001657">
        <property type="protein sequence ID" value="OXU23300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYD0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8610" checksum="207E3AF8A4CE5503" modified="2017-10-25" version="1">MNLAEVIKRLLFSQNFNLKYFYSHNQKDSGLAVGESTLYIRRYFDNSTRQDVRDIIHLIADEFQNYINKVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYV5</accession>
    <name>A0A232EYV5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001600">
        <property type="protein sequence ID" value="OXU23467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYV5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11439" checksum="8C18172F8C99DC4B" modified="2017-10-25" version="1">MGFSKTIILYFESKASTDDKTLDNARIIRKQVQQNPNLKSLLIGSFKIHALKKSLKIQRSPQGKQGTLNENKQNKGLMNKNTRTNLKVLATIINKNEGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ32</accession>
    <name>A0A232EZ32_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001524">
        <property type="protein sequence ID" value="OXU23692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ32"/>
    <dbReference type="STRING" id="543379.A0A232EZ32"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="11194" checksum="46F5C98831BB5002" modified="2017-10-25" version="1">MDQIRNFRDFLRLYNQISDTCFTRCTNTFTTRDIELDEANCVDTCAQKFIHTNHRVMEVYMEVQAAIVQKRIEEMNAAQAAIEAKSAEEQNVEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F119</accession>
    <name>A0A232F119_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SKP1 component POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_001100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001389">
        <property type="protein sequence ID" value="OXU24147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F119"/>
    <dbReference type="STRING" id="543379.A0A232F119"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="4">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="192" mass="22103" checksum="70E08CD68C022B03" modified="2017-10-25" version="1">MSQMIRLEAGDGTGYTVDIGIAKISKTIKNMLEVLDMEVIENETVRLPGIYNGKTLLAVIRWAHRHIDDDVDPEKVKANLQKKDIYLSDWDRELLEFERKEMRLLDMVRAASYLDIFGLVLTCSKYTALLIKEQKHHMQIRRAFKLKNPKVPSKPAQDTEASAMEIEEEMAETSSKTILYSKNCSDDLMESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1D8</accession>
    <name>A0A232F1D8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_013427</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001276">
        <property type="protein sequence ID" value="OXU24521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F1D8"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10305">
        <property type="entry name" value="GST_C_AIMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000011">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053837">
        <property type="entry name" value="AIMP3/p18_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056533">
        <property type="entry name" value="KIF21A/B_hel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23204">
        <property type="entry name" value="KIF21A_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="GST C-terminal" evidence="20">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="19">
        <location>
            <begin position="172"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="709"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1149"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1216"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="526"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="990"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="725"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1149"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1221"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="243"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU24521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1601" mass="179320" checksum="46D77CBAF9708DAF" modified="2017-10-25" version="1">MVLCSIECVQRISEYLDVSPGKLYVSENNTVATSGLVNNQSTEGFSTIVQALVKNSKYPAILGDDAVTQALTRQWLEYAVLCVNYADNSANEKRVLKELNTVLKMSTYVSGTKKTIADATLYYAVHGIMQRLTPQEKAEHVHLSRWFDNMQQDEKLRQTMDLINFNMMHLIRPQVAREVIDMCRICTQVPPGEPQVFLGPDKAFTYDYVFDTNSDQSSIYETCVARLVDGALDGYNATVLAYGQTGSGKTYTMGTGFDVEIDEEVVGIIPRAIKHLFDGIAEKQARARERAQMPPEFKVTAQFLELYNEDLKDLLEPGGPRGGARIHEDTAGNIHLAGVESRVVTSPQDALEYLRLGALSRTTGSTQMNTQSSRSHAIFTLYVKQQRCIKVEDPDADVDTSSAMETASEFETLTAKFHFVDLAGSERLKRTGATGDRAKEGISINCGLLALGNVISALGDKTKKALHVPYRDSKLTRLLQDSLGGNSQTCMIACVSPSDRDFMETLSTLKYANRARNIKNKVTINQDKSSRTIASLRREIQQLQMELLEYRQGKRVVGEDGMNDAWHENQMLNSELQSLRTRVKALSETVDALTAKNSLLLAEKAAGQWMSSGAAASGGDVTGLVQGYLQEIEELRARLLEAEALYQQLKKRQMHQSFGIDSHLDDSLQMSAASNPYGDMSHVIHNDSSSILLDAKKELQREKALLASLKNQQAQNSNMSSRDGDDGDMDDTENGQESMSEDESDDDSDRKEEDEEEEAMGRELENLTSNIDVKQRLIQELEQSQRRLQTMKQHYEDKLAQLQLRIRDTQDERDKVLSSLQNQPSAPTEKVKKLRDEYEKKLSAMQKEVKILQSAKKEHARLLKSQTQNENRLRGLRNELAEMKRAKVKLLNKMREEAQRHKENELKRNREIAQLRKESRKNANMIRTLEADKRMKEVVLRRKQEEVTALRKRDRGLSQKVAGRTAPAKVLNPKALKSRWQTFERTITKQALAKQAAAETEKEMERLLQEREELGRELERLKKHKLVVASTKEDTTDLDEEIDNVTSKINYLQDSISECQRAMVVMGDGDGEVDEDPGVEALLSTIRTVDEAQYLMQRMLAFTIEQSYIAAQKQVEARDMATRLNQVAQESDVQHQLLEHVLRDRDLLSLTNSNNSNNTNTVAYSPPSSRSSSPDNSESLTQSIGGDDKPRSIKVRRRTTQPQELLYGISASTENQKNEDQNQNQHQNHNHPLTRVPSAPGSLKEQVAHMDISSPPGSPTTYRRFNSREENVFSRLTASRQTLHVEHQPTKGVISNYQGKVSPLILITLYKFIMLCIYLLLKLDRTVKVWDLGTGIESMTLSGHPNNVVVVKYSSVHRLLFSVSAAYVKVWDLRAGNSCIKTLFSSGQAQSGPLNLSTPSRTLQMPVGETTINDLALGLDDRELYTASSDKVRIWDLRKLAYVGKLSTPHAAAVMCLSVSDDGRVITGSKDHLISLVEPNMSGQSLSLSPPHYDGVQCLATYGNTLFSGSRDMCIKRWDLSRMELVQSLNNAHKDWILGLCLINSGSVMISGCRGGILRAWTVPNFGDHAGECSLLGEVRAHTSAINATVTNQQHIFTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1L9</accession>
    <name>A0A232F1L9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IGFBP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001220">
        <property type="protein sequence ID" value="OXU24696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1L9"/>
    <dbReference type="STRING" id="543379.A0A232F1L9"/>
    <dbReference type="OrthoDB" id="6611808at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00021">
        <property type="entry name" value="PRORICH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31818" checksum="E373098210BFF4B6" modified="2017-10-25" version="1">MPCDGKNKSCQQRRELLHQLKCLISTMERKKPCEWDEEPCPPEPSKCRVVACYKPSPCQPLIYKSPCDPCSPPMMICKPDCPPCEPICEPLCMPPCKPICQPACKQLLCTPSVPCRPACPPACRPVCPPPPCQVVCPVPCRPGCPPSPCQVICPVPCPPKCSPPCQMTCPMPCPPKCPPPCPPPCPPKCQVMCPVPCPSRCPPPKCAPRLCYTSCSPPEPKMICAPLKRCKSFELRSSLMQKCHCIKRNGLQDRCLMMDCMGYPECMTKLFPICDPGQCALLKLCYLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F294</accession>
    <name>A0A232F294_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001251">
        <property type="protein sequence ID" value="OXU24610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F294"/>
    <dbReference type="STRING" id="543379.A0A232F294"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="156" mass="18241" checksum="7D2AC6152134D70F" modified="2017-10-25" version="1">MKKKIYGIRAKISNNPELNTYIANILAHLKYLIEKDKIFNAHKHPAERFIFKFIGNESKKNALKTDVYFDETDNQLKILCLKLSSLKKYLKELSKYSSSYLINIVTNNTALINNENIKQDFPWIVDHYIKPNKNGVIFPINNLNMNCLFLQCLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F350</accession>
    <name>A0A232F350_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative exosome complex component RRP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the RNA exosome complex which has 3'-&gt;5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the RNA exosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001172">
        <property type="protein sequence ID" value="OXU24883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F350"/>
    <dbReference type="STRING" id="543379.A0A232F350"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="270" mass="29289" checksum="172D12A23338DCDA" modified="2017-10-25" version="1">MEPEIDTSQGGLRADGRRPLELRRIRLRMGVFGQADGSAYLEQGKTKILATVYGPHQPRGKANANALKAVKGIVNCQYSTAVFSFGAGERKKKPRGDRKSQERSQQLRHAMEAIINLELFARSQIDIFVEVLQVDGSEFCVAVNAATLALIDAGIPIKDYAIGCSVTVSDKLLGDDDDSGQGTGILDANWIEECSPGVTLSVVALPKVVDETETKSSVILCHGAGQRLHLSRLEPLRLRALQGCRDIRAILDQAVKDHLQIFAVTAALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F359</accession>
    <name>A0A232F359_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001155">
        <property type="protein sequence ID" value="OXU24959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F359"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="49" mass="5829" checksum="C3C1D5FD57E18441" modified="2017-10-25" version="1">MKFRNENPLKQLLYAPRLLILFFFLKYVGKSEEGLLEQESMLRNGNPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3X5</accession>
    <name>A0A232F3X5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001056">
        <property type="protein sequence ID" value="OXU25312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3X5"/>
    <dbReference type="STRING" id="543379.A0A232F3X5"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF124">
        <property type="entry name" value="FI05614P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601815" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="580"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="734"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="869" mass="95832" checksum="3C112C08571FF078" modified="2017-10-25" version="1">MPRCFTCTYAFIALLMGFQFETRSPLDLRPRLSTSQQTQILSDVQQHQQFSFPSSEGSVPTTNSPFSSLARYKVDRKKQNQQQLQQRIQQFPVNNFNQPAPQLPNIPNDFFGADHQQPSQQLQDYYEKQRQLEILQRQREQLLLEQQELRRQQELLRLQQQQLRSTILPPVTTTTSIPTTTASSILLSSPTARRITPSENDIFLRAIATHQKKFTTTQKPPTTKARQERVQDQNDQPAIPKDLLSLIQAQQNQAGKSKPQIKFIYQTEKPPTSSGKASAGGSSDRDLLLKQLKLALSQSGLDDKERNVTTRDIVLPNGKKLQVIHAPNGLPSNSAATTTTIKPPKAIFEELTKGVVPPGADFEVLRQSNDGKLEDLGKNGLQNQPAKKVTFVVLEEQADGSYKVQGVKGNAEKDSGTDVDSIVERIKKGELKLPPSSKHPTTSTSSPVRTQSADSSDISPNTLSTTFRPTVPTTRSSPQVSISPNSVSSTDKYVTSASSVSGHVLNSLGSTTSKPSAVSHVTVKYPSSSTTGFDSNEIRLSSTTPASSFGHSNSFVDFKSSFPPTSKKPVSSTGQNYAVNRESLSNLLRREGLFAMAKYLRQSGLDNVLNETGPYTIFVPTDKAFRTLLVQLGGPEKAEQKFKDNPRLLSGLLLHHVVPGAFKIESLQDEMTGVSLAGTQLRVNVYSMHDHEWNDIKVTTVNGARVAPNKRDVEIPQGLAHAIDRVMFPLPVGDLVQTLQADRERRFSTFLKLLHASGLEDMLSGTKTFTVFAPTDAAFVEAATKNGGTPIWQESDGPEAAKEIVLRHVIPTTLYTAGMRYYHQKETLRQQVPLQIQKTGGRIRVNEGHIITYNVPATNGVLHAVDAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F491</accession>
    <name>A0A232F491_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001030">
        <property type="protein sequence ID" value="OXU25422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F491"/>
    <dbReference type="STRING" id="543379.A0A232F491"/>
    <dbReference type="OrthoDB" id="6343844at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="517"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="762" mass="87786" checksum="1B6F3A1D0617BB57" modified="2017-10-25" version="1">MSGFDVMTDSAFSDGLQWSLVPNKNPNVATEDHLQSLGLNVQDGLPKFKLNEVGPVALASSIFQKNYMNVDGDSEQSFVVLGETSLQSIRDDALASYTEIQQKSQLADHTSMISMMSPSEIEEKLKNALEENIKLKETLKQNNSAIKQQFNTITMWQKDVMTVCDNHKQKFMETKKLMSHLKKVNDELRENIANYKNQLQKSSLNSSSATGLSLESVNAASLLNKSTCVSAENLPILAGFNTSLLEEEKQLENNKIQLENEQELLKKIDTLTEELNKVKVNHSKTKEVLQELEKRYVSDIELFSQQLQKANKELKVLKQKSDMTNSIELEKLLGKCCEKDLELKYLEEIITSLKQQIKKYEENIFPLIDLQVETSDESSDDTKLLKENVEFYNNKIEELGKCFAAQCSRYMRIQEFLKESADIIQIFENSEVLSNSSLPEDKVKDYKEKLREYRKRLIDEQIQSIDDKQTTIKVQKQFQKMLSDYNAVIYELEILKDENLKLATMQTKASEENSQKLADIEKHLDEEKKILDNEKTELLEQRLSLQFEKKLVIEEKEKIEGERSSLSLEKEKLIEARTSLLEERTSLDRQSQLYEAEEGTLQKEKKLLQKKCDELMNQIEILRHELSKANTTIQQLNVNNSKLKENEEIISVYKIQTEMHQKEFEEMRVTQKNLQDQLQSLSMANLQLRTENDRLGGQANEQDNSDVTINRNRILCPKCQNSISTDNLSLHIALQSRYCGLCAKYIVPGERHGMGICTPEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F532</accession>
    <name>A0A232F532_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_010908</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01000947">
        <property type="protein sequence ID" value="OXU25785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F532"/>
    <dbReference type="STRING" id="543379.A0A232F532"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007398">
        <property type="term" value="P:ectoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000024">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF395">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="16">
        <location>
            <begin position="585"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="201"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11 12">
        <location>
            <position position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU25785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="923" mass="103279" checksum="1AC013CE7F061DE2" modified="2017-10-25" version="1">MTEPIMLILFKKWSKSFSHFKIIVLCARNLARKDLFRLPDPFARITVDGSGQCHSTDTCKATLDPKWNQHYDLYIGKNDGITITVWNHRKIHKKQGGGFLGCVRILSNTIQRLKDTGYQRLDLCKANSDDTDVIKGQIVVSLLSRDGHNGAVSNTVGHNAVVDLLGDLSCPTDLPDGWEERRTQSGRLYYVNHYTRTTQWIRPNSRPSNAIIPTTPEPPPAVCPEPTSPSSSAGSPQNPADGSPSGSRRTSEQRNNSGGGADAPPPAVTNGSATPSRENSAQNTPRSTPTQPPNQNARNTPAQTPNRSTRSSARTPNDEQNGNARSDRGINGSQARRPSRPNRNRNSGIMGSERRTETQPLDLPRGYEMRKTQQGQVYFYHVPTGSSTWHDPRIPRDLPANELELGPLPSGWEMRQTQSGRVYFVDHNNRTTQFTDPRLSTQIINNLLKRQNGTTTQQTNSNNAAAPTRTEPAGATTTPATVVAAAQPATPQNVNQQRPRAESASNNNTPTTETPPTPNGQTVSDLPKELMESELLPKYKRDLVAKLKCLRAELNALQPQTGHCRLEVSRNEIFEESYRLIMKMRPKDMRKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPQYGLFQYSRDDNYTLQINADSGINPEHLSYFHFAGRIIGIAVFHGHHVDGGFTTPFYKMLLNKAITLSDIEGVDPELHRSLTWMLENSIDGVLDATFSVEHSSFGVLKNHELKPGGKDIPVTEENKKEYVRLYVNYRFMRGIEQQFLALQKGFHELIPSQLLRPFDERELELVIGGLGTIDISDWKQNTRLKNCTPDTPVVKWFWQIVESYGEEMRARLLQFVTGSSRVPLQGFKALQGSTGAAGPRLFTIHAVDAPSENLPKAHTCFNRIDIPQTYPNYKKMLDKLTQAVEETCGFAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5T9</accession>
    <name>A0A232F5T9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_004811</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000854">
        <property type="protein sequence ID" value="OXU26194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F5T9"/>
    <dbReference type="OrthoDB" id="9998912at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000046">
        <property type="entry name" value="Attractin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056732">
        <property type="entry name" value="GBD_ATRN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11 13" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="16">
        <location>
            <begin position="89"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="901"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1181"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1251"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="932"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU26194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1282" mass="142816" checksum="C8525D34C28A0740" modified="2017-10-25" version="1">MAEAAQMFLFLYKCKYRRKARAGLLWSLVVWTTLLQCVAPLGTAAASSQNSIVGANASACDLDSCHNGNCVNGSCICREGWQGPNCQYCASKVRLSEPSGSIHDGVGNYTTDVKCSWLIESTANSSIRMHIEEFATECGWDHLYIFDGDSIEAPLLGVFTGLMHKDDYHIRRVPEVIARSGSALLHFYSDVAYNMSGFNITYKINACPSRDSQVDCSGHGVCIEGVCTCDATWMGEACNVPVCPNNCSAHQGQGQCNHEWHRCDCSPGFKGADCNQRSEQGYWNAVNYNDLSPEGSASHCAVVWQDSLYVIGGESFHRAKMIYIYDFNGNVWETPHITGLKPLPRYGHSCVLFGDKIYMYGGVIENSTVTNEIWAFDVSAKLWENVTVHDNCVNKTMCGPLKVAGHTANLVQSHDKKEKMVVIFGHSPQYGYLNTVQEYYFGAREWQIVETFGFPVKGGYGHSAAHDPHTNLIYVYGGYVSENPGTQVLTNRLYSYHPNRPREWRLLTAAPSARFFHTAVFVSSSLMLVFGGNTHNDTIHSFGARCYSSDMVAYDVTCDSWRQYTMPIEMADLSRYGHSATVFSKSMYIYGGFDGQMLSDMLRYTPGTCEHLRNYSQCLNSRIGLKCVWDKKASVCLPITKIPKTVLINDDPHDGRYMRCLYDTLPRGMTSHKELCKLLTDCVACVQTSYNCVWCGKNCAHEVCRNVANAPQTRAINSLDMCDAHTGIECYQLHSCQACSSNPKCIWSWSNGPDRCKPLSEIAIASANNTIQPQRSPVDICRSACVEYTSCRNCTEAECIWCQNEERCVDKNAYPASFPYGQCREWTTVSEKCRNTKSGNEWCSSHNSCATCRADPACGWCDDGSNTGRGKCLPGGARQPSHRSPESCPLDRWYFTECPICQCNGHSTCHPNSSECIQPCGNLTYGPHCEKCRPGFYGNPLNGATCQPCSCNDQGTNCSGETGKCFCTTKGIIGDHCERCDISGLYHGDPTNKGSCFYDLAIDYQFTFNLSKKEDRYYRAINFKNSPPKSDVDADFSITCSAIARMNITIKKANSPEKPLLLGANCTNLIYKHRFSKADYNFGNEDNNTLTTFYVYVYDFQPPLWIQISFSQYSKLNLQQFFITFSTCFLALLLVAAILWKIKQKYDMYIRRQRLFVEMEQMASRAFSQVLVEIERRDSSISETDGSDTEMNNSRKKKKKKDAPSPIALEPCCGNRAAVLSLLVRLPTGGEPYTPAGQSAGLAVASALVTLGSPRRPSQELTIKEPKKSRKSSSQHPESSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6H8</accession>
    <name>A0A232F6H8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Nucleosome remodeling factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_003860</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000889">
        <property type="protein sequence ID" value="OXU26049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F6H8"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15559">
        <property type="entry name" value="PHD1_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000048">
        <property type="entry name" value="nucleosome-remodeling factor subunit BPTF isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="15">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="338"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="2526"/>
            <end position="2577"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="2582"/>
            <end position="2633"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="2660"/>
            <end position="2730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="940"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1232"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1552"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2019"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2155"/>
            <end position="2268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2310"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2464"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="811"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="940"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="964"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2027"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2155"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2198"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2210"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2250"/>
            <end position="2268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2322"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2343"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2379"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2408"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2464"/>
            <end position="2478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2489"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU26049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3195" mass="357759" checksum="4F65A8914688C208" modified="2017-10-25" version="1" fragment="single">CRGKTEQHVGSRDEAQGPAAQVGRHGAAQKVPVSPHEEAQVSAEQGLGNAGLAAXXXXXXXXXRPSSPQETPEPQDTRRSTRNRKSKAGAREKHSKKGGHSGSTYGRRGYNTSVDYHDSEYHYGSDFGDESSDNKTDIEDDPLLQSEDESSESIEEPDPSSDSDFSLSSFSTTSGTPRRTLLSQQRPPSPEPLWLQNKEIPPLDLPKSSDDLLVPKDLVMPCLSIYEVLRHFRTLLRLSPFRFEDFCAAMICEDQTNLLAEIHITLIKALLREEDSQQTHFGPLDQKDSNILTVLSNSEYPFSGIEDRIKVLQFLTGQFLITNPVREDLLHEGNRDYDDHCRVCHRLGDLLCCETCPAVFHLECVEPPLVDVPPEDWQCNICKAHKISGVMDCIPDVEKNGLLCRQEHLGFDRHGRKYWFLVRRVFIESEDGEIWYYSSPLQLEELMNSLDKNEMEVALYRELSDYRDEIKRQMELTETITNQYKGNKKSYLEVENSLIQKMQKERQEKLEKEEEEKKEKQRQEAEELVRKIHEDSESTIDKPSVPSEKAEDKRESEEQSEKAGKSTEGQENSLENTDNENKSKIEGEDMEVEEMTEGVDKDGKKHNIVTRSKTGSLTPRTFNIDELKKKALPGSKEEQEKTEKTLKEETDNARLTRLKAHQIASGTHLFKLGMDNSFKSYVNQYSTNTIALNKAQRNEERDKKRHLSHKFALTQSVDFKWIGSLTGTRAMLVQTLRQTILQLESCIQAPFMHTNWPLLRKPWTIAVGSCVNPREFARALIALQACIKSVVFANVWHEQLGHVKLQRVTAIEREEKKRLDKKEKKEKEDEEERNRLTYNFVKYTLGLKHQIWKQKGEEYRVHGQWGWLWISTGRRHKSVDLKKMGLRAGPQKIMVQIRDQIGLKILAVDPSTYEFLLKEYYPPDITDGTDDKDKIKKEIKSEEASGDGTEVKKENQNEASTTNESKEVKTEPSDEQKTEPKTETPAPKPETKLNLPFLAGMKIQKVFKPVTQFEEIDITKALTTSGRLLYPKIGKKTRIDDFLARRTHLKLLEERKLSQSEKLKEIANKASNQKANEEETDIDIESTEDNENGSGGGGDATLQNILKNKQPVKVMGPNTANVLAAIGKRIQQVRSQYANLMRLGGKNVACYSRYCNLASQNITNKTIITPQSLATNCYSPVCLKKIQLKRDLVVLLRKANALNNNAAAANTALVKTEPSSEDSKENIVKTESATVTPPVADEKTSNNTETTIAVPKDGGGDVSSAKKTKLESDENTGSKSNQVVVTTNNVVTTTTVTTTTQQIKTIDGIVKNMQETVTSCSSVDVKSEVKTSVTTSASPKTTTIVNRRGRTVQRIIYAKELNADGSERIYSASTAEGKIYLKKVAISLADRRKKRTPVKYPLCSTFCSKNKHRSILVLPQHELRKLARTGGRQPVQGFHHMAKANMSVWPYPCPRPLFKTCWLYRTVGLRSLAAAAIQLRILWSCIRWDDVSAKPLSNDGKHQITTDTEIMSLEILKHRHVGQFMDKTQYLRRKVVIPLELPKQIREVTSIRSGLRKRKRPESPQSTEPQVSEEWVDEDKLELWEIKQYGERLEKANAQIITRSRSGQPQTVVVSGNRTVGSITSGDQVSGKSTPEEIKEKMEQQLRLQRAAHQQKRALENLKNPGTPGTPVTQLVKVTTNNAQDGTLKVVTKVAIPANPNTPQGKSQLTSLLTTPTQNKFIGTRRIYMTKTADGTTRVISGPTSILPKTPQQQAQTANQQSLIKTTGTATPNNTPVQPVQQKVQILRGPDGKLQVRGLMPGQQLVQMPDGKLHVLNTAQTVAATTPQQQPAGTPTTGTATTTAQSVPKIAVNVAKTAATPVAPVKTTPVKIVANQVQQNTTPQQTPVQLQQVVQAGQRLKAAIVSPGAVTSPVAQPQKSTFVVANTGQVMQGTQVISTSGQVVTANQIIVNNPALAQQLASGKAQLATIGGQQVLLRNTTGNLVQLNSGNAGIIVRNAVTPAKTQTVAPVQQAVLPATPTTSISETPASNSATSTATVASPTAASTPSTPVSQTLPSTAVQPTTPATPAPGSVEASLLVGQPPGTVIKCVTAQVIQTTQGPRIVLQGLQGTDFTPNQLAMVHQQVKQQLLKAQATAGKQGVLGPTKIYLAVQPSPSTQAQPSAQPQQNQAPQTPTTQTVGTPTTKPPPTTTTVQQPLVTEQSNAETQIKTEPTTETPKPTEVSSPKKAKVVVQQVQRGTPNEDEPQKASIVNGQQPAQTPKESSINQSASNKFVITPDYIQQTIKNALKQENLNPEIEEKLLQLQRYQEKQMKGTEGAATGAQSHSTPVTSAPRAPARKRPTSTSHTPAPTTPAVTQATTNEKDNEWITETPKRKTPSKQENRDNSKSHKLPESLDNDSTPKNRPNKLKDTQEQRRKQQVHSRMQVLLFRHKELLKKDILKRRALLEKELQIDVQKDLSAELASRTKAERHKQDEVKVGSAKRKANAQPPQQISSPNKNKPKKQRSQGHPPTIGASVSNRIKKEKLYCLCRTPYDETKFYVGCDLCNNWFHGDCVGITEEMSKTMSEFVCTECRHARETQELYCLCKQPYDESQFYICCDKCQDWFHGRCVGILQSEADNIDEYVCPNCQRNSSVNFANMKNLNTKDLELLKKLIKQIQGHKSAWPFMEPVDPNEAPDYYKVIKEPMDLQTIELRINDRSYKKLSEFIGDMTKIFDNCRYYNPKESPFFKCAESLETYFDSCAEQSRQHILYNTVFNIALLDALGHGLLQYSYAFLKIIHDSYPVVDREVTSKLYIFHNEDEGKEFLAKMKQEVQHFIIRNTETLKAAKTHMCSLPRVFWFENHVANAESLKGNLETKLRVFQNYIVNEVDLSSEKSCSKDCPHFSGGSQVQGCFDNKICAKQRTCEGKLWNCYEESKIIVCPASKQNNNIRYDYIDIKKKRYGEEKSDNCKNEVVEAKTWLRLPYKCSNCMCICEVSSPKADRVVTGMKFELKNGIIHIRIKQSKLLANGLIENAVSELPKSEQWKKVDGYTINDKNIFEGKDYYMLSWQNRTMCLDELDSLNKSDVLTGLRFKLESVNDQTYLKLEVRLTPYDFTTGRLSDKNSYWYSNGLQQNDRTELKLDSSVTANSQLDSYFKFTTNLEIDAGQSTVPHVEHVELETKVSVPLSGAGLFINKDLSFKWKAFTFDVVPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6K5</accession>
    <name>A0A232F6K5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000790">
        <property type="protein sequence ID" value="OXU26496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6K5"/>
    <dbReference type="OrthoDB" id="7634767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="15045" checksum="21849814E40738D8" modified="2017-10-25" version="1">MIHRLAMLHFNVADSRPRHPPLALPTDYQQQQHHQQLFMRYLQSDDNYNEYSLPPPPIAFRYESPSYSRSLSITDPSYDSFNSSNNTNNNNNEAGSLIGSVFDENDYDDVVEEDSPKKGLLKQMFCLPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F707</accession>
    <name>A0A232F707_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000836">
        <property type="protein sequence ID" value="OXU26260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F707"/>
    <dbReference type="STRING" id="543379.A0A232F707"/>
    <dbReference type="OrthoDB" id="7701645at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="443"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1216" mass="137572" checksum="22EFEAFCD1EC0C3D" modified="2017-10-25" version="1">MSKRRNEEMPVATGKKRKETPGQRGEYSSESEDGLDPGSFYDRDYDAGSDDGSGTEDVQKFRVARRTTHLEHFSGAVLRARESRRTRRGNSGGRESRRRGQGDIRCRPVGTQVTGRQTAPFSVEKNRGEQGEAIVAEENLDDEAREILGVDPLAPKSLNVKLHPSVLRRGKFWYENGLSKDEKEDILEKYGTPVGVVVPELNREVEKKLPSHAKTRDSLMRKRQLLAAAAFKANGWLLSTFVDNKEGVDRLQCLEILTDVAKLLAEIMNSQTKSRRALILGGLNKQSKNILEETRADNLLFGEKLTEKVKESKSMESWKETDPRQHRPPARFQLIQKQRARELQEQLPQPAIQSEGPIPGTEPVQKSGPEKIGNVGKVVGRLRKFVRSWGDVTSDSFILRCVSGYKIEFCSEVFQSKLPRERKFSREEVRQLEMAIEALRQKGAIEACRSHERQFISSYFIVPKSDGSSRFILNLKQLNKFIETPHFKIEDIRTATGLVFPGYYMAKIDLEDAYFTVSVHHSSRKYLRFIFQGQLYQFVCLPFGLSVSPFIFTKLLKPVVTLLRAKGCMIVVYLDDFLCIGTDAMDCKKNVSMTVGLLESLGFCINKRKSCCEPATRCEFLGFIIDSSSYVLELPTKKRKVLLDKVLGIFRKRSCSILLFAKLIGSLVAACPAVEYGVVYTKALERLKTLALFRNDFDFDAKISIPKSVLSDLAWWINAIPRTNNSFKSFDFVMELYTDASNTGWGATTGNTECHGFWTEEQKNFHINYKELFAVKLALEKLVAHLRNCQILLRVDNTTAIAYINRMGGIRYESYNKLAKEIWQWAENRKIFLFASYIPSGENKEADRLSRLVNDDTEWELNNSIFANIVGIYGQPEIDLFASTNNAKCKNFLSWRPGPGVMGVDAFTYNWTNWFFYAFPPVSLILKTLVKIRQERSSGILVVPFWAGQPWFPLFKSLLCNEALVFGPDINMLLSPCRKKSHPRASHLKLMEEVAPSGIPSQTDGRKSIREAFVRKGVPMEAMGIILASLAPATIKQYEGAIKKWERFASQKELDFLNPDSAGLISFLSDSYEEGASYAEGLEIRIPDLIKTSGPGRFQPLLILPRFKDDPQLCVASVIERYVEMTKDFRSETDSLFLAIKKPHKDVGSQTTNRSISCRIGGTVKSEWNCVPKGRPLESAEPEEASAAEAPDEDAAKEEEQEDVPPRSGEREDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F791</accession>
    <name>A0A232F791_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDNF/GAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000825">
        <property type="protein sequence ID" value="OXU26313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F791"/>
    <dbReference type="OrthoDB" id="5950623at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039596">
        <property type="entry name" value="GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16840">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16840:SF3">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GDNF/GAS1" evidence="7">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="214" mass="24151" checksum="C4EAAD52134EF3ED" modified="2017-10-25" version="1">MSTDEGKELMRCDCAENDVMCKFSKQRAEICRASVTATMNRTRVSCRVATWICIADTLCSTALQYYNENCKRMFHGKKCTKRCRNSINILRRQEKAEKLNTCYCDGIEEYDCTAIHRNMDELCFNKPAQHNYQEQELGASGGAGSGGGGXXXXXXXXRLQERGPQDEQAAGERGRPTGQRLLEDTAARARAPAPLPPRPRRMSGDEHWHRLQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7W3</accession>
    <name>A0A232F7W3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_005972</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000693">
        <property type="protein sequence ID" value="OXU26946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7W3"/>
    <dbReference type="STRING" id="543379.A0A232F7W3"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000288">
        <property type="entry name" value="Sex combs reduced"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF6">
        <property type="entry name" value="HOMEOTIC PROTEIN SEX COMBS REDUCED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="257" mass="28597" checksum="5086317ACB5E03F4" modified="2017-10-25" version="1">MAARLRGSAHKGGSSAGSREMDRQVENFHRILEHAGCTPAMNPTLSTLTIDEDVVTSDDGTSALCSLHPCALSAGRVAAGRRITDFTQNTILQSHTEGYRCRRGSSTLTTASSASSPASSTSSTSSTGNNSSNKGNGSGGNPPQIYPWMKRVHIGQSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMSPYGHPYQFAPHPGQFAHLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7X3</accession>
    <name>A0A232F7X3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000691">
        <property type="protein sequence ID" value="OXU26956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7X3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="18444" checksum="211EC6F323B7C74B" modified="2017-10-25" version="1" fragment="single">MSLTISSDSTLVVDLMSSSGDIFILCDELDSSPLLRDPRADAVTTSICSFDKSTYEIKYLKGNDAKGGESNSFSSAQAAKGSLFYGEKVEESWLPPLCWGDKSRELFCADACTMSPLELVIIVDGILSLLSNRMAQQNELCTAVREILGGEEELVRRGETVLRETLNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7X6</accession>
    <name>A0A232F7X6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000777">
        <property type="protein sequence ID" value="OXU26558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7X6"/>
    <dbReference type="OrthoDB" id="7683787at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="18629" checksum="7EA92A61D66C2AC0" modified="2017-10-25" version="1">MDYESLPIERNCGSLSNNANDAVGVTDSPEIGRDSPPPTIYSFVERRRIPRRSRWSLLCWTGGRRRRAALLESDRRAPPAYSALFPRYGRRDEDFEALVGTDRAAVLITGNPWTFVAPTPPPSYAQDQGICVAYSLEQLISNSGDFFCHCKFVIEGISNLLPFRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F801</accession>
    <name>A0A232F801_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000724">
        <property type="protein sequence ID" value="OXU26785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F801"/>
    <dbReference type="STRING" id="543379.A0A232F801"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013122075" description="BTB domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="50"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="222"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43730" checksum="E5BB4A042398B70E" modified="2017-10-25" version="1">MGGKMLGPMQSASLLGLILMLPFSLGTRRSYNPTTATNAEFGMTRMILASMNYTWTVSSFSVMMDRMETGQYVESSKFSPPDAKTHKFCLKLYPKGETEDIKEYVSLYLNYQDGWSDSVNIDLRFRLLNEQGQPFNDGMSFKNWEVKKNNGVGWRKYARQDWIKDRTNQALSSLDQITILLEFTVYIGYNMDSGQCRTVLREPPAERMSSDMYLFLDNAKYSDMTLVVKGIEMRAHKFVLAARSPTLNTLLDEAEQSMRMSHPVITIDDIDPRVMNEVLRYIYTGEIRTLEIRTRELLHAANELELVGLKEMCERQLCLNIRMDNAYDMLRLSVKYKADGLRLRSAKFIAAHFGEMSRMPSLLWQQIHNTGCISSALYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8B6</accession>
    <name>A0A232F8B6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein son of sevenless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_013174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000744">
        <property type="protein sequence ID" value="OXU26718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8B6"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22914">
        <property type="entry name" value="HFD_SOS1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22915">
        <property type="entry name" value="HFD_SOS1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01261">
        <property type="entry name" value="PH_SOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000029">
        <property type="entry name" value="son of sevenless homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="205"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="440"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="7">
        <location>
            <begin position="608"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="792"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1299"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1348"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1359" mass="153496" checksum="737F5756D0EDF45E" modified="2017-10-25" version="1">MFSSPTSTVGEPLGYDFEKEENAAKWKGVFVNSLRKVLEQVHPSLEARQDALDYVESLILRMLGMLCGQPPPHTPQDVEERVRRTFPTPIDRWALKDAKEALEKGKKKSPLVLPVDKIHQLLQKEVLQQKVDWQVTLFVVGVLEYISADILKLAGNYVKNMHHVAISYEDVRVAIDADSVLMDMFHQDDCAEGAQTGLATVVSQTYEESVRDLIHDERHYLRDLHMIIKVFREEIMKLTQDRTELEMLFSNIIDIYETTVNLLGSLEDIMEITEEKQTPTVGSCFEELAEAEEFDAYIKYAKEINSPACRDVLTRLLSRPEANAALRAAGHGFREAVKYYLPKLLMQPVWHCFLYFDYIKVLQKRTPSIEDRETLEQVQGLLRPLQLNLQDILDTYKCKRDSSLRMQSRARRQAALEKTSEMQKTVDGWDQRDIGQCCNEFIREDMLGKVGSNGRRLTERRALLFDGLLVLCKPSSGKRVSVSVAAVAVGSNHSAHHQNDLRLKERFFIRKVDIIDREDTEELKNAFEIAPRDHPNVILVAKSVEDKNSWMADLVMLNTKSMLERTLDSILLDEERKHPLKLPPPQMYKFAEQDSPENIVVEARENGGVPLIKGATLVKLIERLTYHIYADPAFVRTFLTTYRSFCSPQELLSLLIERFEIPDPAKVYDDEERPTTGCKSIPREDFKRYRKEFCQPVQFRVLNVLRHWVDHHFYDFERDKSLLDKLLDFLNTVSENCKSMRKWVDSVMKIVHRRSNDSSEQRPITFSFERSPPPIEWHLKVPEDEWGILTLHPIELARQLTLLEFELYRNVKPSELVGSVWTKRDKEKTSPNLLKMIKHTTNFTRWLEKNIVEAENFEERVAIVSRAIEIMMVLQDLNNFNGVLAIVSAIFSASVYRLQCTIQQMQRVARLDKALTDAQELNIDHFRKYQEKLRSINPPCVPFFGMYLTNILHIEEGNPDFLPDSPLINFSKRRKVAEIIGEIQQYQNQPYCLSIEPRIRRFIENLCPFDPEISDADISTYLYNKSLEIEPRGCRQPARVPRKWPDLNLKSPGIKARSLSGKLPAPLQAVASSVRLHDPPTMSQEISAPSDLPETPPHGSSFSSTTSDYSVFAPVLLGSMNAPSPGSPGPALSMSSLSLGSPGNSPQLGSPGHLPTHHQQSSSYGGSSSTHFGFNSGTIGAMSGALACLASSSLAGSPGAASMMPPPASPSHMPPLGQPPPPLPPRSHRRRESCLGDSPQQARQAPNAPILPPREGISPPPLPPRREVPSSNIPPRFPATLNPSSSALLLRRNSTLENSCPINTGHARRHMSFNGPSPTQLPPSQPSNGSVTPRLPPKPQIPGRSPATMFNFNAPPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9H8</accession>
    <name>A0A232F9H8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_008788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000686">
        <property type="protein sequence ID" value="OXU26967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9H8"/>
    <dbReference type="STRING" id="543379.A0A232F9H8"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF95">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669407" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="29"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="290" mass="32140" checksum="6EAB2D93FDA30EFE" modified="2017-10-25" version="1">MTLSTIFKFAFLVMASCSVDHADSKHVRMVGGYVAKPGDFKYQVSVQSNHVHMCGGALISDQHVLTAAHCLVNRPDNHFYDEKVQGPLTVKAAIKNLNDPNFVYAEVQELAVSDLYMNSQELFYVYDFAILKLRTKIDLRNPNVQVVKLPAFNTQDIYTGKYADVAGWGTAYNVVTKTYVNPNELLALTLEIWDTEYCNQVFGGNLQVDAENQICGYAPRDDGKLYGTCQGDSGSPLVYQGTVIGVASSAPIPCGREHNPSVFARISSYIPFIRDAMAGRYSSEFAVKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAI6</accession>
    <name>A0A232FAI6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000529">
        <property type="protein sequence ID" value="OXU27856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAI6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="11211" checksum="A1DAFBFD0AD9E08A" modified="2017-10-25" version="1">MTLLKSPNDQVRCDLLSQDCRRELTLYSLNAAENSGPLKQRRFPEDYRRDSKNHVPARTPPANRLSGLAVTDRPFSLSALKVTIKIHGVKLLEGVLAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBE1</accession>
    <name>A0A232FBE1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM21/CAPZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000470">
        <property type="protein sequence ID" value="OXU28146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBE1"/>
    <dbReference type="STRING" id="543379.A0A232FBE1"/>
    <dbReference type="OrthoDB" id="751084at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="79330" checksum="E07F2DDA99613A08" modified="2017-10-25" version="1">MQEASTGSDSIDKPWDHAWSTEEMRKNRRDWSLAGDSGLLKHLQQFSENLTKKANTTQEAIDSMTSQLNQTAILVDNITNTSLALANTQFIESRVQEDNTEIEQPEESITKNEDEHEFSATDLLVSVCESIRQGLSIMDEKYEKVEVVASDSEDEDDNAVPSVILRPKDPYQDRPLPYVIGTEQWKSSNKIGLESSSSESEQNDDDDEDSASDTDDKNIGSMLNPNVHTNLGIGRLSSTSSESNDYNIESSSIKDTDNSRLHARSQDTLNLDTEPTTPSSVLPKTQNINNGPPSFAEELAKRLGSVLPAQKNTIAQGTNEQVINRSKDEMLTPEDEQDVFSNKSDNLFNEGKNLFSEEVSSSSWKNKPIRPRNKNIIPPSIDVPPPLTSAPKSTIDDLFGDADDSEDSDDIFSKKASRDIFAGEREKIRSEVASTLKNPHVENVQNISTMTTSTPETNDKAKGLFEDEEDDDLFGSASKQIRTPDTSSSASSKKKPVGGVSIFGKVDILSSSKFARRPSSSSSSESDSSDHRISSNPSENATGQSIVSATTSKSNSSSGANVSSSIEAGNNANERQQAGNNTGSSGSSGVSVRQPSSDFTVGSSLGNNNIQDISIQDNVWTSNKKHSSLLTKEILNVVILCKLVYDNIQDRVYCDPLRSESVYPHNIFLILTYPTDRTLVLSKLHLTPTHLSFNDFGSSLQYSDSNQGMIQKKPDTFEGLSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC46</accession>
    <name>A0A232FC46_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000437">
        <property type="protein sequence ID" value="OXU28396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC46"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="174" mass="20131" checksum="53D37287DA4855EF" modified="2017-10-25" version="1">MYCKQPTMQAPENQFLPHLPQVLQQQQRFAQAPTVQVQSVQHIQWLYYQQQLQWQQQELKQRQFMYQQSLPPPQQSFELMQQNLENQILCLNHWLKLLQEKNGVAVAENHANEYSDVKTAHSSVGVRAGMKANDVKNQRLASLLHTLAFYDSSRGKRGRGGGHGRGQGRGRGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCS3</accession>
    <name>A0A232FCS3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000407">
        <property type="protein sequence ID" value="OXU28611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCS3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="8926" checksum="AAF4F18EEAEE20EC" modified="2017-10-25" version="1">MDVVKSFDMSLSTPNIADKNSTTHNDCTTCGTSLNRINTNSDMLTSCTRSTSELTSNDVLPSDVFKGLNLRKHKIMGKNLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD31</accession>
    <name>A0A232FD31_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_007127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000392">
        <property type="protein sequence ID" value="OXU28691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD31"/>
    <dbReference type="STRING" id="543379.A0A232FD31"/>
    <dbReference type="OrthoDB" id="10035606at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15846">
        <property type="entry name" value="SNARE_syntaxin17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059001">
        <property type="entry name" value="STX17_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028676">
        <property type="entry name" value="STX17_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF139">
        <property type="entry name" value="SYNTAXIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26585">
        <property type="entry name" value="STX17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="311" mass="35063" checksum="88A403249F0F20DF" modified="2017-10-25" version="1">MDLRKINTMSSSLDSEDVKQPIKRLEIPISKFNDVAIPHHLDLLKRHKNNIKKSQGLRDWDRVYTEQINASRIVKQLKQLLHEMDTLRGQVQDSDIATFDKLTMKARTSTLNAIKEYLELELNLPLVKKHLTQASDDHQNTEENPLDNRFMQIQAEEEELERQQACLQAWTSLHNDLEELQKLFIDFNQIVHEQAESVDRIENNVEDVQVNVASGTRSLQQASKYKVMAYPIAGALLGTCLGGPVGLLAGLKFGGLTAIGGGLLGFTGGAILKKKCHIDTNLKQIEGPTELRRKPSTSSQELNKFESKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD64</accession>
    <name>A0A232FD64_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="21">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSAR_000145</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Alberta</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="21"/>
    <dbReference type="EMBL" id="NNAY01000450">
        <property type="protein sequence ID" value="OXU28307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD64"/>
    <dbReference type="STRING" id="543379.A0A232FD64"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000010">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OXU28307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="609" mass="69654" checksum="C154BED9342890DD" modified="2017-10-25" version="1">MFSPRDLAKADYVSLNINDGTAFARTTSRSVWRQWNQLSRFQRNICYFAVIAIIILVFYLLSGKTQNNTRVEESDYDSAKIVQDQPKQLKVADEIIIESIDQVGGGNAVGVGGGGNNVEVIDEPEFQPEANQVDDDQIGEPPQHKPQPLKFNGPQNDRQRAVIKAFKHSWSGYKTYAWGHDNIKPISKGYHEWFGLGLTIVDSLDTMYIMGLNDEFQEARNWVQNSLTFDQNRDVNLFEVTIRVLGGLLAAYHLSGDRMFLDKAIDLGDRMLPAFSTRSGVPYSDVNLGTRSAHSPKWGPDSSTSEITSIQLEFRDLSRSSRQPRFETAAAKVSEHVHHLEKYDGLVPIFINANTGLFREYAVITLGARGDSYYEYLLKQWIQTGKTIDYLKDDYLLGIAGTQKHLVRRTAVNKYLFIAELLGAARDMKPKMDHLTCYLSGTLALGVHFGLPSDHMTLATELLNTCYQTYVTQPTCLAPEITYFNVQKSGDESQKDMYVKTNDAHNLLRPEFIESLYYMWYFTGNKTYQNWGWQIFQAFENYTKVENGYTSINNVKNVDNTRPRDMTESFWYAETLKYLYLLFDDTRQLIDLDKWVFNSEGHPLPIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEQ7</accession>
    <name>A0A232FEQ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000315">
        <property type="protein sequence ID" value="OXU29274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEQ7"/>
    <dbReference type="STRING" id="543379.A0A232FEQ7"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="27772" checksum="55AE525AEEBE0025" modified="2017-10-25" version="1">MHIDQLLRLHIHLDIQLVKARKAFRTLSKLFYKKYLEPKAKIICYCLLIRPILSYAGPLWYNQTASSLERIRVFERACLRACLKQYRSSESNYKKMISNKKIYNKAYIPRFDNFITKINRDYFANTKKVTSNNRIVRITEIDTDYIEKCKTSGYLPPESFILLDHQELIQDNNNIPIIYHWYRHRCNKKIPPNYESIPILKYSTAIPARDSNDKTRLYSNKYWWLAADIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF48</accession>
    <name>A0A232FF48_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serum response factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000309">
        <property type="protein sequence ID" value="OXU29315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF48"/>
    <dbReference type="STRING" id="543379.A0A232FF48"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="62518" checksum="EAE56A6101D8BE5A" modified="2017-10-25" version="1">MSKVQINNEIILLRGSVEQARVQLIAKLARDAFKLRKKKGTEQQKAKNVRKADKIAAEILAIKKVKKDEITKYILSNPLNLDEILKDQKAEPLTRIMARIANHKKFSQKIAEFKSKYPNYAEFLGPGRRKKAISEWKENKKSRKAQKEENDESSKNASDAEASENNDESSDNGSEANDDDEVSEGEEVSSDVVEEKESEDSAEEKVTTAKTAKVKKSKKIDKENAESTNVVKGKKNKKLEVKDIVEQEKESDDSEEEDVKSNIVESESVQNGTVKKEKPKNSLGKRKKANKEEKQSTDKDTKPEVKKKKSDTAKVISKQAIVKKFTDILKEEESKPEMKPEINFDSERSNLKIEKEVDSFFFSGDGGENYLSVALPKNNSHEDEEEYGNDRFNKKHFSRQQNDKFFSKVNKFQNNGPNNYNSNRQDSRWEGQRDNERPYSRDKPGFNKFNSRSNDRFNDRPNNRFNGKPNDRFNDRPNNKFKDRPNNKFGNDRNDKPFKKHGQDSFESKSNEVLHPSWEAKKKQQDILKKGFQGKKIVFGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFH6</accession>
    <name>A0A232FFH6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000282">
        <property type="protein sequence ID" value="OXU29514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFH6"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059433" evidence="1">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="151" mass="16613" checksum="E4DF588BE3FA14F4" modified="2017-10-25" version="1">MKVFVALVLCVIAVNGQVTQSVFPSAVDIYKMKIFKYSMECLFERKLDLSKFGLQKDVKKAVEDLHKDEKACFAGCVFKKLGAMNDDGTFNEDKLFMGATAETLPVFKRTHDAAVKHCTDQVGKEDLCKFAACIVIQAPAYASSLNATSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFI1</accession>
    <name>A0A232FFI1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000328">
        <property type="protein sequence ID" value="OXU29189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFI1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012534020" evidence="1">
        <location>
            <begin position="19"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="387" mass="43252" checksum="AEA446FF5E0EFCD1" modified="2017-10-25" version="1">MLYQKLVFVLLVLATANALQIHKFSRASLFRGSVIKINRTLIEISNSANSISLTWGNDRKSCSLSFPALLKSSNYSSFVKVSVLGNDKIILRSYESDGSTKTWRFLVVNHQTCVSREIGEKIRTDIQDADISTVIAYNDSFDIFSDNKVCSPCRYNDKGEKIKLDHTLVQSSTSGLRDSHSDKKIRISPINEKTSSEGYLLIQEFSNNCSTLLQRLDSTFQVVAQRHLNLTVNAFSTDYEKLRICSLPHCNSNGKSAAREPLTCQLLDAGNLETLNTSKLDQVASGRDLKSVLVQNLPDGTAKVTYVYDKDCFEGDGEGAFAEIYDQRINVGGKVEQAIKFQESVLCWDYRLESIVLGPDEYCTIAYDGVATVEFPQTVYQTCTRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFJ1</accession>
    <name>A0A232FFJ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000340">
        <property type="protein sequence ID" value="OXU29077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFJ1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="12894" checksum="0CB2AE1DD53C5804" modified="2017-10-25" version="1">MLSEFREQFDKIDQFFEAYSEVDMLDERITISDLTIRFMSYLDYWFEMLKDKKMTIREKSNESRPKRMRNLSLVFKRVDRLKALMKIIDYKILNVKEAIYCKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFY5</accession>
    <name>A0A232FFY5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000291">
        <property type="protein sequence ID" value="OXU29430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFY5"/>
    <dbReference type="OrthoDB" id="7695925at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="467" mass="52492" checksum="205270B6C36A35A0" modified="2017-10-25" version="1">MASYIYAFVTISSTKKNIYIYIYILQGTITSFTILLAFSEISYAHVLEKPANGTRLSTDDFGISQRTSNASSAESRAPKLLSKFDASRKIQVDPYTGYWNVSSNGNYSSIRAHSPNLNRTEMWNSTLLDAFLNRRSNSQHKYPNGQYAVLKTESGHQQDKSKSYATSEDYEHQVHNIATEYFPPQTQEYDESYNTIPEDMNTGYEVPVTPGYEPWRVSYVPHDPGYFGPPIPVGEAPVHPPSSISRFIYYLFLIITKIELLISFSAAGTRECNCPTTTRSYECDNPSGNFLALVSALGQNLWALVSLIATSSNFLFQKIQDVFPDDNSHHPPHPHDAESRQADDGKNASATFARDDSVLLLDDSSVWDLRQCPSRVACEMGAFLAGAGRTSFFPQNLANYLAGRADRAMRGVRPRSKKNEGDDEEEEEEEDEDEEDQRDQAFKAFLVALGKKWSQEQCQVYSCAVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGY6</accession>
    <name>A0A232FGY6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000210">
        <property type="protein sequence ID" value="OXU30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGY6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9709" checksum="A4A972815236F45D" modified="2017-10-25" version="1">MSSMEEKKQLSGIKVSAIANKFQLNYITDNYDNKSGFDIEMNDANKTLSHTHTHTQIYKETQTAVIQLPTQMAQQAYGKKLRWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH48</accession>
    <name>A0A232FH48_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_017053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000198">
        <property type="protein sequence ID" value="OXU30064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2386367at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1723"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1741"/>
            <end position="1752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1901" mass="215403" checksum="AF3A889F203E6318" modified="2017-10-25" version="1">MIGEEHRILPNMIQLLQNGFENEVDNNSPRNIALVLGLAGSYKYDLIRLIIAKNKQVNHNININTNNQNSLNNTITVRKNFPDFIIDSIANTAFYDYSEFDESKTVEEEISAKFLLNKVINYADSIKIILTIPEFKIKSSSADEHINLLLDNVVEIIQDFDKLENSIALVVTKVANDNLASDGNFIEKIADNLRKYSTDEKSALKKQNLINILLKNNNGVYTNIGVFRKPENLGEEISESEVSRIDLKSLEMVINVNTKFVKHDKNNFLYYITSDPLSCTDCLDKLVNGIKSGISIGLREIGQNIKQFYENEELRLKDYKRFHDEISLGIKSLEGLHNTSFSSTTEFLTKLIHLKDIHTMIPQKIILSINSYAEYLNFIQKSVNKSSKYSELEKIDSLSFRNHFISIIDEITEDLRNSQSWYTFLIDFHNSLSRYSAQEARESIKGYTKHLINEHLIWNDKEMRQKMELDEENDQSDINPSEYEERKQNIAMSVEKIITTANLNNWDQISSSLAKATISNTKLKFLSKMLESLLISPSDKIISTCSDNKLQIQGQFIKLSDVSKEEHSKCKGKPVKEIELFASNTVFIDGALNKTGEEIQLSIVAPTWEIIGKPKIILDGKPGEPHEVDTAPDTFTVPGAAGNDGLPGKPGGPSGSLLAIGSNFINEENLVISLVGGKGGPGQKGSDGVAGKDGNLDPKVKKQDGKVVNYLDICKQVSENIVKTCYECTDESNKCQNGGKGGKGGEGGKGGRKGRVQPIKLNGGYANIRGYITDGSDGPNGEHGNSKEGGLAKILKFRLCVSESRPKPIKPNKFQPVLHLITNENTIDKRCGPEKMDEKSFNSDGKEEPPFLNTRETAYILNDYKKYIISILGTDEKIREESLREFLDQIENDSHFQDLNDCMPLIIELQNLEAQFFELHKKVSLLPFYESLLRRTTQYAKSFYQEREKNIEKYDEQWFDDRRNALTYLYTATFSKIISIRDNKSSNMIINALAYLDPAIENIEKFNDISKAVLMDKVQSDYYNLMDDKIKEAMVFIPLIKDKTKNIIKNVDAEIRTLINEIQTLEGKVVKQRKELEIMGGKLKNAIAIRSFLAVPQIVAQILSLTGPIGQTVGTVITGSSMLIEALSVRDVPKENIKVEALPKVFDRYMSKIGEANDKREMLQKYLGAIEEEFKNTEKKVAPPPSVLELRDNLSNITKTIEEEKRSGVSPDKISEKTDAVKALLDQSVTKLGSTLADKNYTNNTIIKTWSKHINRAANSFSVMQVPASLFKSISADSEKVDLVVRAIKESGDQLKKLDMHKKEIYEHVIPQCRGLQKQLSELSNDSTADKSHAALDISKWKIQGMLMLLKSEMRKMTEGLSVQEDIARLMEELNYALSTMIDVYDRIQDYRDRKELADYIKDINPTASDTETIIRDVTLKNAVDKLKLIIQSNIVLEEHERAIFAIKQRVYPMAHKFLAEYQLPFASNLSISALATKAAEKLRNIKNQIEVDNITILKEDKFWFDDAPFTVEDGARGPFYVWKYAENKQAISRLLRGKEITLKSHITKSNPEFSAVKFRFVGIKFNFADKAAQKEFEGILKDFKLTMVHMGNSQYKCNDKFHVIMNDKHNFTVEYSTLLGNRVHSKIKKQEALLSPYTSWTISLQQNLLKRDFASLAQYENMTIDLALEGNGTYIHNTDERFIVHKICNDDLAKYYKDDETISGLTTAQLFNKEVLDEIPGIGYTEDQKPRSRIRRSLSDDELEQDEDEDLFSTSGAGSSMKSSFINNIFNLIGTGLVAYEYLNPVNKIKQWFNKYETNIDHEDFVVPDNNIPTDMKMLNVQPPADTELPKVAEMFIDDDLPRVNNLLNDATFCSHGNLLLLDLFIRSKSGVKYGHERLAVKPNVNLEYAQHLAYGKQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHE8</accession>
    <name>A0A232FHE8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000195">
        <property type="protein sequence ID" value="OXU30102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHE8"/>
    <dbReference type="STRING" id="543379.A0A232FHE8"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="7">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU30102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="146" mass="17479" checksum="1ED8DBD2ED0A72A1" modified="2017-10-25" version="1">MTAYFLFQTSNNMCDIKDDVKDALKEFRFRKNPKNAALLLKVDREKQKICVDELIENVQIEELQDIIPEHEPRYIVYTYKMEHSDGRISYPMCFIFYTPSNIQMELQVLYAGMKLVLQREAGLTRVYEVRELEELTEDWLKEKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHI5</accession>
    <name>A0A232FHI5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000190">
        <property type="protein sequence ID" value="OXU30135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHI5"/>
    <dbReference type="STRING" id="543379.A0A232FHI5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="218" mass="25445" checksum="FB5DA968AB716B1E" modified="2017-10-25" version="1" fragment="single">EQNKTYSQCMRYDINWTNFNFKDTADLISLSNDSLMTIPCDKGWEYNQSEVPSSVVIEFISYSKYFLDLGCNTYYCWINNSSNISNTFYHIPGISGSKLSIFCYCNDLYFLYHGLVYASRCYILHTRVENFSPCNKFLPESPRWLLTKGRLLEANDILHNLARVNGTEIPTEFCMKMHSQIERQKSMICEDDKSGPNVLDLFKTPNMRLKTCLITLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHK4</accession>
    <name>A0A232FHK4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000189">
        <property type="protein sequence ID" value="OXU30155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHK4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="56" mass="6027" checksum="D2B3DD60693AAEAF" modified="2017-10-25" version="1" fragment="single">IGSVKSSTKLKLSIFVTSGYKFKPTAAARQYRLDPHAPDDQVCSIATAAGTQRQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI19</accession>
    <name>A0A232FI19_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000164">
        <property type="protein sequence ID" value="OXU30396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI19"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="148" mass="16170" checksum="60CAB4CCE7C1B91A" modified="2017-10-25" version="1" fragment="single">MTTLGCLAYAEASTADPSEHCCAECICASCLSSVVPLSRGLMRVGGMPRPGNRRAYMPSKALLLFGEYGSVKSPRYELLRKLSFMNILDHYDVKTQSYTNVIGSLVTTVDSSVRHPMVTLPQTRKVSVRMFGSGDAMSHIGTESTLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ49</accession>
    <name>A0A232FJ49_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000154">
        <property type="protein sequence ID" value="OXU30509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ49"/>
    <dbReference type="OrthoDB" id="7697071at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="260" mass="30127" checksum="6BA014EC5A9D957C" modified="2017-10-25" version="1">MAGWISGSESDEEPLNLNLFNRKCFGFSGIAEDTVNTFKSIVQQLGGSCDSHPKYVFTTREYYDSLDEKDSNLYNITFIRDCVDANRYLNAEQYRFDFKDEKRDFKDFDPCCNNFHKGEKGCFLCDPAYKKDLPTKQRRKSKLQMNQTKGDEGDASHIVKTMCTKTSKKKLLGTMGDSDVLLTHRTPDSMRVYFCKQILPYVDSYDLPKPIKRKFNQVYNSAYPARSSQVKLKVKGKKVILKRQMCKKQIRKPNQSNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJV7</accession>
    <name>A0A232FJV7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cilia- and flagella-associated protein 52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_001908</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Important for proper ciliary and flagellar beating. May act in cooperation with CFAP45 and axonemal dynein subunit DNAH11. May play a role in cell growth and/or survival.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Microtubule inner protein component of sperm flagellar doublet microtubules. Interacts with BRCA2. Interacts with the CCT chaperonin complex. Interacts with HSP70. Interacts with AK8. Interacts with CFAP45. Interacts with DNAI1. Interacts with IQDC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CFAP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000124">
        <property type="protein sequence ID" value="OXU30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJV7"/>
    <dbReference type="STRING" id="543379.A0A232FJV7"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000207">
        <property type="entry name" value="Cilia- and flagella-associated protein 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001320">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF14">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="488"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="572"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="740"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="783" mass="86463" checksum="2A6BC318235B710E" modified="2017-10-25" version="1">MDIQDLELGGIIAFDGLTKNGLQLHPDQEHFVYPMGNKVTIKHIETGIQQFLSGHTNLISTMCISPCGKFIASGQINHLGFKAMVIIWDYREKKIKASHEIHKVRVEDLCFSCESNYLISLGGRDDGNVVIWDVNKNDALCGSFASTEIAGNAYTIRRTNLRDQCFVTGGDRTLKVWRINQETRKVYGVDVKVGKLRRCINCIVIDERDELAYCGTSSGDIIKARLNYYHNMEHMEPVQPPVMVGCYSKISKDAKNRKIGIGDLYSGGVSNLLIFKQDKIIVGTGDGSIELATIVELNVKQDKKIKSPSTPQIKTLLSGNVRSAVTSMILWKNEFVIVGTALSEIYQVKLSDFDMRLLVTCHTSTIYDVAFPHDYSEIFATGSKNDIRLWRLETQKELLRITVPNIVCTSLYFSYDGRMLVSAWNDGIIRAFTPQTGRLIFAILHAHVKAVSAITLTKDGKRIISGGCDGQVRIWEVLPEVQRLVCILKEHRGSVTSLNINHDSTEVISSSTDGTCIVWDIDRGVRKQVLMGTTMYMAACFSPNGVQILTCGTDRKITYWETLDGSMVREVEGSGSGALNSINISPDGQYFVTGGNDSIVKLWSYETGETTHAGMGHAAIITACKISPDGKHIVTVSGDGAIMIWKCPFEMKSARSTGKRIAASVTSRSTCSLREEELKKRLSLDLGDENVADFSPRSEALESVKAVYKGSTETPPCKCDPTQPIPNSCKCKEGDVKSPIIETTRSSKSSQSEKSRKSEPSVKSCKSNESSVKNCSIERKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK41</accession>
    <name>A0A232FK41_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000089">
        <property type="protein sequence ID" value="OXU31101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK41"/>
    <dbReference type="STRING" id="543379.A0A232FK41"/>
    <dbReference type="OrthoDB" id="302770at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11202" checksum="842A165BBF7C3E4D" modified="2017-10-25" version="1">MLIRSNDFLLQNHEYSGYGDEPRRKREDNNKPNHVLLFTIINPVYPITVVSIKESWGKSIFSARSIGIELQLTTPAMEKRKEKPRLQTNSTAISSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLM3</accession>
    <name>A0A232FLM3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_017007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000055">
        <property type="protein sequence ID" value="OXU31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLM3"/>
    <dbReference type="STRING" id="543379.A0A232FLM3"/>
    <dbReference type="OrthoDB" id="7700707at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="583" mass="67607" checksum="A1769CEF8AB711B2" modified="2017-10-25" version="1">MENNPSRNKRNYGNSPRPNSPRKAQKVDRQQNAPTSSSSPKKTAAVLQNLSKSTSSTTLNSKMSNAAKLRQQFIEEVKDIELSLKETIKNYKSKISEAEKKSAFITEKLREKNKLLCHKSEIIFTKERENKILREKVLELYDYQKIVFENMEDISNTLEVQKDLSDNLQNVYDSVMLMQQNTNEMLEEKLNEITPDQNYCDDLTELNMKINELEKNIHQNENLNHQLESKIKAAKHNKEEEQKMINDLDKKINEVETRNNLMKQNAEKEKNDLLQEINNLKQEEKTQTVKMTELDSTISKLEQELQSNRTQGNEIGLEINKINDEIKSLSEENEKLKKNRCKEDEEQAVTLQQLKEQLKLSQSKLASIKQKENQVSNVLKTKNEELRTKLKGYDGIEVKVQKLDLAVNKEQEAITQITQESESKIREYNNKIKLIEKDIIEVKMKIKQKESKMQESTEKIRSLEEEVLQLNEKLTANLNMRKNNTEKQVVGPSGLPELFTSDGIHNAEKQKNRKKLYTPTLADDDLEIDSLSIEDQLNHLTQSKSSNSHSPEKSKRFFKNSSLSQAKSKKESTPRSRGRAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMR8</accession>
    <name>A0A232FMR8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000034">
        <property type="protein sequence ID" value="OXU31748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMR8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9603" checksum="ED27E391558571A5" modified="2017-10-25" version="1">MCMHRASDKRTLGQFPKRNSTSANTFSIRRRRRRRSRGSSQNSRIHIHILHDVEAAQRNRGVTQEREKESRLNGNAREFAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMX4</accession>
    <name>A0A232FMX4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000009">
        <property type="protein sequence ID" value="OXU32074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMX4"/>
    <dbReference type="STRING" id="543379.A0A232FMX4"/>
    <dbReference type="OrthoDB" id="10051896at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="30"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU32074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="181" mass="20020" checksum="F41E8110CB13C85E" modified="2017-10-25" version="1">MYQSREFIMLVYFKISKPPVEKGGTSKNGIIGGEFTVINTAQILLNKIQDCGEAILSEYWVVILLLIASNGEYTVITGSSVREVRGQRHRVEKVIIHEDFDNITLDNDIALIQVEVPKVYDKVYIAGYGKEGAVVLPIYSKKNISCIRESEITDNMFCAGAEEDNACQGDSGGPAVINNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNU7</accession>
    <name>A0A232FNU7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNU7"/>
    <dbReference type="STRING" id="543379.A0A232FNU7"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895604" evidence="2">
        <location>
            <begin position="16"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU32189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="502" mass="56957" checksum="CD2B983966D2CC4A" modified="2017-10-25" version="1">MAVPLLLHCITLTCGIDTFWRIVQDEFQSPVWQQRFIAVERATLIARFMDSTPLKNSTSLQTSLANIFCYLINSMDDNNVYVAQKATLYLGTIHDIAVKALLTCMETQFDLVIIDRPIILQTLYQLHNCLCDRRILTWEFFLNRFDTLFIEAQINLERKEDREEEADKAFTLLSERIKSFVDFVLPRSNVHKEVKMLARATSKALGEYAKLRHLSPALATPTVKRKDGGCQTYPIFRQNILQNTVEHELPSTPLPPAAKKRKAKGDTQGQSKAPDWATVVKTGKKRTKGNQPKLARGTSESKAGVRPPRPDAIKIKASSGCSSYADILWKVKFAPELKTLGDRVTRIRCTRAGELLLELRRPGTETADLKTVVSSTLSGNTDVNNELFIKKLETAHEAISQFDGTEKILKTLSASFGEKWPYKRTMSAPSFVLPKHETRQDKEKIYNRQYSAPILKRKSSRFGLGQLIGYTLPNNSITDKDTQYENVVINNLTNYNPYFKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FPC2</accession>
    <name>A0A232FPC2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000001">
        <property type="protein sequence ID" value="OXU32298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FPC2"/>
    <dbReference type="STRING" id="543379.A0A232FPC2"/>
    <dbReference type="OrthoDB" id="7695643at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU32298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="480" mass="55076" checksum="79DD31D13D398D55" modified="2017-10-25" version="1">MKIDEGLFILFSASITSAARKQNKDMCLRSARLKEHEETNEIGINALNDDCLMHIMQYLPIVDRVRIERVSKRWQAISRDAWRGFKNLNFSNECWGFSTAKTLTKVDHVIIEKILKRCGKFLNLIWFSSDSNKKLNPNLLKNVAKFCPNVQHLDVWRICISPKSWKALCKSCNNLISFAASDCTDDELSLLFDNNKKLERLSVNNSEITGKCLRKLNCYSIESIMLVNCRNLKLDNFHVIRGFRNLKQLTLEEFYFQNVFAEDISSCYKSLKYLTLAYGYAESLHQIAKLINLRTLDLSNGPVDDELLVSIGVNCKLLKDVDITNCLQVTNTGLASIVSLPNLESLFVEDLNNVDDEVFRAMPTLRQLDCSGCTNMQDAGLIKLIERSENLEHVFLENCDYISNDLLEAAVKATKRRKNQVMLKLHVGDKNIRRLKASVISPFLPIFETIIDQSKRFYYTEHQSFVGSYPFVEVQKFTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED31</accession>
    <name>A0A232ED31_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01008936">
        <property type="protein sequence ID" value="OXU16252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED31"/>
    <dbReference type="STRING" id="543379.A0A232ED31"/>
    <dbReference type="OrthoDB" id="10028922at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="86913" checksum="4B759922F69A2B14" modified="2017-10-25" version="1">MSSERTVRRRVAEKRKLFCQEITECLNNFPKICENLTSDNSDGIEKSKLTDDEIPSVNPALNFMCLMNTLVIGKKTSLDELIASQFKHCTDKAELSKVQLQKEVFDIDEAKIHEAAIKETATNSTLTLNNGNELSTGKSFNLRYYLQNCNDEESDEESNSVSDFVLVENDDKVLFMDEIRQLCLKYIHIITHEFTEELLSTLRKHTGTPFPKSAKTFFKTPRKIETRKMASGEYCHYGLESAIRSFIDMYLNKGIVVDCVKLIVGIDGAPLATSSEKGLWIIACSETVLKLVEVLAIYHGEDKPPDVNEFLKQFKEEITFFINNGIEHKDKHYCILFYTLVCDAPAKAYVLCVKYPSGYFSCTKCTIRGQYHNAVHFPGAICSLRTDEKVKSREYNDPLGDDYQKQGETILKDIPKFGLVTNVVLDYMHLICLGVMLKLTEVWIKSILCESEIEKISEKLSTLKNFVPSDFCRNPRQFKKIRRLWKATELRQFLLYTGPVVLLDVLPTKLYTHFLSFHIAISILVNPILCKSEDYLNYADELLKKFVKDFEEYYGGKNVTFNVHNLLHIVSDTRNFGPLDDFSAFRFENLIRKMKQLVRKGDQPLVQIGKRLAEIKSSKAYSDEDNEEFDVSMYRTMQEIYVFKEDSIFLDCRNTSNNCILLNNGTYMECHYFIQDKKNSLKVVGNVLKVVENFYKDDFKDVSDKLHVKIVRESKTMQSVAYPADLILAKVCKFPLEDNKHFVVIPLVHTYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDB9</accession>
    <name>A0A232EDB9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006883">
        <property type="protein sequence ID" value="OXU16351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDB9"/>
    <dbReference type="STRING" id="543379.A0A232EDB9"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076496" description="Glycosyl transferase CAP10 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="8">
        <location>
            <begin position="137"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU16351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="400" mass="46565" checksum="C17D98A289D79AD3" modified="2017-10-25" version="1">MNWIHLVFLILLHDARCKSETCSASDEASCEKSTSKPAEKYSKDVNTRYSRYLSAIEEAEANYAECDSKKCKCFGDVITRDLKTFAERGIDQELIEAARPRGTFYQIIGGKLYREKNCMFPSRCAGIEHFLLKVIGNVSDVSLVVNTRDYPQSSRHFGQPLPVFSFSKTPDYYDIMYPAWVFWEGGPAISLYPRGLGRWDLHRKSLNEAREENPWEKKEDKAFFRGSRTSSERDNLVLLSRAKPELVDAQYTKNQAWKSEKDTLNMPPAKEVSLESHCSYKYLFNYRGVAASFRHKHLFLCGSLVFHVGDEWTEFYYGSMKPWIHYIPVPKHASQQQLEDLIQFAKDNDAVAKRIADRGRNFIWEKLKMSDVTCYWKKLIRRYSKLFKYKPTLEKDLMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE72</accession>
    <name>A0A232EE72_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-terminal amino-acid N(alpha)-acetyltransferase NatA</fullName>
            <ecNumber evidence="4">2.3.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_007702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50500"/>
            <dbReference type="Rhea" id="RHEA-COMP:12701"/>
            <dbReference type="Rhea" id="RHEA-COMP:12702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12707"/>
            <dbReference type="Rhea" id="RHEA-COMP:12708"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:65250"/>
            <dbReference type="ChEBI" id="CHEBI:133372"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50504"/>
            <dbReference type="Rhea" id="RHEA-COMP:12703"/>
            <dbReference type="Rhea" id="RHEA-COMP:12704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50516"/>
            <dbReference type="Rhea" id="RHEA-COMP:12709"/>
            <dbReference type="Rhea" id="RHEA-COMP:12710"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64739"/>
            <dbReference type="ChEBI" id="CHEBI:133375"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50508"/>
            <dbReference type="Rhea" id="RHEA-COMP:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12706"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64741"/>
            <dbReference type="ChEBI" id="CHEBI:133371"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50496"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133369"/>
            <dbReference type="EC" id="2.3.1.255"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.255" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01005572">
        <property type="protein sequence ID" value="OXU16628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE72"/>
    <dbReference type="STRING" id="543379.A0A232EE72"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000101">
        <property type="entry name" value="N-alpha-acetyltransferase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU16628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="21185" checksum="95287FC0693272E9" modified="2017-10-25" version="1">MSINIRCANTEDLLNIQHCNLQCLPENYQMKYYLYHALSWPQLSYVAEDEKNRIVGYVLAKMEEDCEDNPHGHITSLAVKRSHRRLGIAQKLMNQASRAMVECFGAKYVSLHVRRSNRAALNLYTSSLHFQVSEVEPKYYADGEDAYAMKRDLTNFKQDCHSSKESTSVDFYSSNKKCCEHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFN3</accession>
    <name>A0A232EFN3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004987">
        <property type="protein sequence ID" value="OXU17134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFN3"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11529" checksum="F13C49E4BE25E18A" modified="2017-10-25" version="1">MSTYRLFAIMASLKEESILQELRTRSNIFSAWVGYHDRLALETGSRYWTSPSARTAVSWTDVYENLMDNGGGIQHCAVLMKGGIDDINCNTTVPYFRKISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFR1</accession>
    <name>A0A232EFR1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004955">
        <property type="protein sequence ID" value="OXU17183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="12" mass="1402" checksum="0648EB0548B2CAA0" modified="2017-10-25" version="1">MYNSIDVTPKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG23</accession>
    <name>A0A232EG23_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004885">
        <property type="protein sequence ID" value="OXU17297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG23"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="221" mass="25114" checksum="0E089468C8D10FB9" modified="2017-10-25" version="1">MTRARQQKGKRFMGRHVPFPEYQEPRDVRKLLTPTMAKEPSFRMPLDQATHGESNAERALPEALAPSSEGAAPFNDEELSAAPFGTEESHQREESSTLMVQDETSMQLDATANPITKLMQSIHQGGIPRYLGPLRRPAIAAVAGVVRIDGALDDTTKESREGRRHEERREERRVNEIVNVVDVEMSAEVERNAEDACKLRRNSTSISFRRSHQSKWRRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGH5</accession>
    <name>A0A232EGH5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004757">
        <property type="protein sequence ID" value="OXU17460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGH5"/>
    <dbReference type="OrthoDB" id="7701337at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="29069" checksum="DB942ADC6D2CB601" modified="2017-10-25" version="1">MKNKSMLIGTAIFIENDLNLEDKKRQEEINRWIKLKKGEGWQVKQGTIGQEWREKQIIGKSTGEEINIEINKKKKIIFWNIAGIWNKDKEVWKFVKKGDFISLSETWLEDKDWKKVENKLPTEFYWRAIPAKREAKKGRARDENVIIGGDFNIRIGKEGSLVGSANNEFEMDRRSSKDSIVNNGSKNLTDFCNKRNWSILNGNFVGDEEGNYTFIGARGSTVIDYIIVNEKVRGKVCRFTVDIESSQIIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGP0</accession>
    <name>A0A232EGP0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004735">
        <property type="protein sequence ID" value="OXU17494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGP0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="301" mass="31620" checksum="B9F08CB0E59466C5" modified="2017-10-25" version="1">MLSHRVDQKCLECSKEDRTALPRQLEVEHLTAKPEGKTSTSKNLNSDPAGASTAGDSSQNQTEIVAGGSSGEPSGNPEQSQGGQIGMGVDLQRPPAGANMRTAGVSDTDLFRGGGGSQNPQADLVTDGLRSVKLRPKITGAQRRKEAQSRKREGEAEAPGEWDATPPSSGSVTSFLPKNLTAGSAGGDGRAPGVKRRKNADSTPPADQTARKRPNVEPEIMAARIVEGVEYRKQGGVVLWNLPGAQHIRNLGKAASATSNCTGVWAGLPSGWMRVPEGSANRATLSRPNHHGCRRDSAHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH28</accession>
    <name>A0A232EH28_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01004605">
        <property type="protein sequence ID" value="OXU17666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH28"/>
    <dbReference type="STRING" id="543379.A0A232EH28"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646946" description="Palmitoyl-protein thioesterase 1" evidence="10">
        <location>
            <begin position="27"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU17666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="308" mass="35137" checksum="9EFFCA64986CD58A" modified="2017-10-25" version="1">MTAPGQASLALLIVLASLFQSHRIHAENTTTSPIPVVLWHGMGDSCCFSYSLGQIKTILEVNIPGVYVKSIRIGNNVIEDVENSYFKNVNEQVKQVCDELAQDEKLTGGFNAIGFSQGGQFLRAVAQRCGHPQMMNLISLGGQHQGVYGLPNCASLQHYLCNHLRQVLHYAAYSKYIQEKLVQAEYWHDPLKEEEYKKNSVFLADINNELRINEMYKENLQKLKNLVLVKFEKDTMVEPRISEWFGFYKSGQDVEIETLHESSLFIEDRLGLKQMDAEGKLHFLSVDGNHLQFTDSWFVENVIEKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI60</accession>
    <name>A0A232EI60_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004339">
        <property type="protein sequence ID" value="OXU18035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI60"/>
    <dbReference type="OrthoDB" id="7701117at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="503" mass="53948" checksum="5C7E92F7AAEEFE82" modified="2017-10-25" version="1">MNAVCNNCRKTETPETLPPETSTPAVLTSATKLTQESDKSARRKPSPPSGKSQVSVRTGPVLRTKSATPRSFATPYANTRSGVRSGRSAATSPLSAPTRRRSSETVAYRAAIPLPGGSLTSRYLLRWYSQSRESSQRSLNASVERVTDSQAPALLTSVSADESFAQDIMNTQKTRAKDAPLGDTSYLGVSNILIPVSTMEFFFQRFDMLQDQLDGLRALVSRGSVPRGISSSLAEGGATVGTEELNTRISALETQLANNISTSNRLLDSNKLLLDENSILRDELQQTQQLLGRIHRARQDHDTGSMTVSGKGPMVASSPSIIIDREATEVAGARKCSSPQLAPTGGGAGSERGGTEGPVRAQRNDMTATKSATHRGVLPSLVVRLASPGLVREVMRAKSALANNYLTTNDIKPGVLDPEAAACLSGQKVCINEMLSQEKLSQFKNLRPIAQGLGFKYVWHVGGRFLARRTEGCCNCCRFAGHSYGVSGRLESASTTEDTDDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ02</accession>
    <name>A0A232EJ02_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004124">
        <property type="protein sequence ID" value="OXU18333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ02"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="120" mass="13022" checksum="5D7016437140FA34" modified="2017-10-25" version="1">MARGETGRNPLDRVCLEHDIAYARNNGYGGGGGGNGGGSGGGGGGHTEADRRLTERAFSRMLSESSGSEEKSVALLTVLCMVGKITFDRVYRRFRQAIKRTRRKRTRSVGWRQSTNGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJQ3</accession>
    <name>A0A232EJQ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003972">
        <property type="protein sequence ID" value="OXU18552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJQ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257635" description="Secreted protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13074" checksum="565DCA6231FC30CB" modified="2017-10-25" version="1">MALSLFLAAAQLSPLSPRTLEPWEYTLSLSLQLVNRSHCVGGRESAHVFLPSLSLLVSLFGMPRETVTPRLRDRSKIYIPSLSFSRVILLFSSSCTLYIYSLYVEYPHILFHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJQ8</accession>
    <name>A0A232EJQ8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003954">
        <property type="protein sequence ID" value="OXU18593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJQ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624337" evidence="2">
        <location>
            <begin position="24"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="277" mass="30798" checksum="6089833D00E46C56" modified="2017-10-25" version="1">MTDIRTLFIVLIVTVALFEISLAQRLLMPSIERCGSGVKSGVKGGFGAKGGCRSNQGDPQPGIKRPIGGYGNSQGNRKPGTKQPIENYENDQGNQQPGMRRPVEDYWDNRGNRQPGIKRPIENYGYNNQGNRQPSMRRPVEDYGDNQGNRQPGIKRPIENYGYNDQGNQQPGMRRPIEDYGDNQGNRQPGMRRPIENYSDNEGNRQPGIKRPTENYGNNPGYKAQQPAVRRPTGDYDAGCGVKGGCGAKGGYGNDRRTYHGPEDYGRANQQNKEVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELU3</accession>
    <name>A0A232ELU3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003763</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003496">
        <property type="protein sequence ID" value="OXU19325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELU3"/>
    <dbReference type="STRING" id="543379.A0A232ELU3"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="289" mass="33264" checksum="EEA66A4700D2DD85" modified="2017-10-25" version="1">MAAILRVKRKKDHEPLDALLISCKRQKVESEEDSASVPLTAIVKFAGTVEKQDDCVIEHITKTFSKDVLKSNYKQHIVDITKKAREKTKQVSNENRYKIINSIRSLDTSLLKDLDEDNVNIIDIEDTKAAADQKTDVDYVYDLYYTQTKEAIQLENLLSVVPIEEDFVFEDYYKDNDYQGESEDSNSESNWRNDYPDSDHSENSIGENDIRNAMKNLTVADESSSDEDFVYGLDEEDVERYGWKYAHYKARIKKEMEDDDKSNGDYHSDMDDFSSSDQSSDCSVNGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM46</accession>
    <name>A0A232EM46_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003424">
        <property type="protein sequence ID" value="OXU19430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM46"/>
    <dbReference type="STRING" id="543379.A0A232EM46"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="198"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51770" checksum="C448900C6D36DA53" modified="2017-10-25" version="1">MDDICVPKSPIPDKWDTTRMEIIKFKYMWTISNFSFFWNNTPGAYMDSPVFSTGANDKIKWHLRLYPNGNYYASDYGNIALYLYLKSCDAPSIEAKCKFSIINNRREETNVKSSRYCHRFVKIIDSQRFTGLANFISRDYVMDQSNGLLPNDTLTILCEIRACRGIINILGLSISEQLKMPRSQPDDFGALLDSEEFSDVSIIVGCREFKVHKAILAARSPVFLAMFKHDMKEKNENIVEIRDMDERVMREVLRFIYAERVERIQDMANDLLAAAEKYSLEGLKIMCEEALCGKLTVNNAADVLALADMYNADCLKTQVIHFLVAHGKDPSLWTRYLNASTKSQSMFAGFSDILSNYVKLLIISSLCAFIAILLVPYVSLLVDPMCDVTAKFCAPHKDIVMDSDTVSTVLMKMQKSASSFMEDLYAFFLYFFRLFLNSIVNPFSVENEFQAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMF8</accession>
    <name>A0A232EMF8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_008965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003367">
        <property type="protein sequence ID" value="OXU19536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMF8"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="484" mass="54580" checksum="621B0E171B2FD904" modified="2017-10-25" version="1">MAAENEQKDYGKRIEYDPLWKGPLQEKRTRTDSKFLIAFGVFMLIWIAISAYALVAGDFNIAINELQDEYERNSWNSNNVIHAMKIGIGFSILAGIVSVIFIVLLRWYAKFMVYTAIAAICIGLLVIIIYVSVLSSSLHDSSGLIAIIVVLIIMLLVIIVCVCYFHKKINIACEIIREASKAVMFFPSSLAFPVLPNLFYILVTIFALIVLMNLLLMGELKNGNFEAPPHVYFLLIVYLFGFFWLCGFITGFAEMTLSGTFSTWYWTLHKAYVPKNTVLHCMGTTAKYHLGTVAFGSLIIAICQLINALLSYARDKLQQRGNSFTCFCFGWYQYLFQNLEQFVKFMSRGAFVMSAMHGTGFIQSTKDAFNLYMRNILKVIVTSSVTDGILVLGSLIAIGISTLATWGYCSSQNLDHVMPPAFVSVIFLSALISWGFFMVLKSAIDTIFLCVLEDYERNDGSEEKPYYMSLKIQSVLFKEQSENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMY0</accession>
    <name>A0A232EMY0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003257">
        <property type="protein sequence ID" value="OXU19724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMY0"/>
    <dbReference type="STRING" id="543379.A0A232EMY0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19116">
        <property type="entry name" value="AKR_AKR2E1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000023">
        <property type="entry name" value="aldose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000013">
        <property type="entry name" value="NADPH-dependent codeinone reductase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044488">
        <property type="entry name" value="AKR2E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="271"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="543"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU19724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="838" mass="94790" checksum="94A4754FF4C7CDF9" modified="2017-10-25" version="1">MPMIGLGTFLSKPGEVAEAVKYAIEVGYRHIDTAFFYENEKEIGSAIREKINDGTIKREDIFVTTKLWCNSHKEDEVVPACKKSLENLGFDYIDLFLVHWPFAFKSGDALTPRDAAGKIEFSDTDYLETWKGMEECKRQGLARSIGLSNFNSEQIARLLSTAKIKPVNNQVEVTMNLNQKPLIEFCKKHEITVTGFSPLGRPGNRHGIQNLWDEPQIQELAQKYKKTPANIACRFILQLGVTPIPKSVTKSRIKENLDIFDFSLTPEEAKSEELEEAVKYAIDIGYRHIDTAYLYENEKYIGNAIREKIKDGTVKRKDLFITTKLSYYAHKESEVVPACKQSLNNLGLDYIDLYLIHWPIALKKSTDFKSFTDRGTRIVADIDYLETWKGMETCKHLGLAHSIGVSNFNSEQIKRLISTAQVKPANNQVEVSLNLNQKALITFCKEHNIVVTGYSPFGNPGNSRGLDNLWNTTVIQELSCKYNKTPAQVTLRFILQMGSAIISKSVTKSRIKENIEIFDFNLTLINMAVPTWTFNDGNKIPAIGLGTYLSKPGEVEIAVKYAIDIGYRHIDTALLYGNEKEVGDAIREKIEEGVIKREDIFVTTKLWSNTHKEDQVVPTCKKSLANLGLEYVDLYLIHWPFAFKEGDELLPKDASGKLLLSDTDYLETWKGMEECKRQGLARSIGVSNFNSEQITRLLGSAKIKPVNNQVEVSLKLNQRALIEFCKKQDITVTGYSPLGRPGNRYGITNAWDDPIIQELVKKYGKTPAQIACRFVSQLGAIPIPKSVTKSRIKENFEIFDFSLTDEEMNSIQSIATGERVAPMEDAKESKYYPFNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN01</accession>
    <name>A0A232EN01_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003275">
        <property type="protein sequence ID" value="OXU19701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN01"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="5619" checksum="0F87B6B1F8A4574F" modified="2017-10-25" version="1">MWQLRTLMAGNAAARKGTLWSNKSRCVQVTLLAATKKRTAPFRETALRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN75</accession>
    <name>A0A232EN75_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003202">
        <property type="protein sequence ID" value="OXU19814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN75"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="244" mass="28248" checksum="8A8EB913199C17F8" modified="2017-10-25" version="1">MYRTNKYPENWKCSFTIFIKKADGKGVRPISLGSCVCKVFETLVKNKLQYWVEKKKNIIPKSQSGFRKGQNTVDNLVNLTLHVEQSFNDIKDLLAASIIAPGKIVIEVKNVKIKTSGTVRFLGILFDYKLTLKSMNIIKFLRRTWWGADANTLLILYKSFVHYANFVYFPTNKQLVQKLERIQYAALRLSLGYRNSTPTNVILAESKMLTIEDRTIYLCHCHLYTILSNRNLIVNETIRSLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPE9</accession>
    <name>A0A232EPE9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002955">
        <property type="protein sequence ID" value="OXU20223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPE9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="58" mass="6163" checksum="35D6A6AB41E477E3" modified="2017-10-25" version="1">MKNLNEGGRGSEAEGYRAAPPSQLEVEHPTVKPEGKSVKGNTAHNTLTRWITGTASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPP7</accession>
    <name>A0A232EPP7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002916">
        <property type="protein sequence ID" value="OXU20323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPP7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="147" mass="16528" checksum="0255B8B2ECD050C6" modified="2017-10-25" version="1">MILRNYPRNDELKLQRGKKRNLSRCERKDVQEREKAQQYQQGKQSTNNEVLEVKKGNRDAADTSNQDDQRDGAVATDCVEDDELHSQEAESPRGVGAAGSSQDDELNVHGVGRDENDEAGWNAYDEVGSSEDDEPRRAGKIVCYCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPT7</accession>
    <name>A0A232EPT7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002873">
        <property type="protein sequence ID" value="OXU20399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPT7"/>
    <dbReference type="OrthoDB" id="10460776at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="393" mass="44649" checksum="E7905838559AFEA4" modified="2017-10-25" version="1">MPATIKKYVSADDEGDNFEEISEAQELKKVNVDVQMKKKVAQKGRDERVLEKLKKCFEVPVLLDSQNRVDDLRYTNNRNVNVVRNVRIQFEDFMLSKDKASQNKDDSQKENASSPINSQNARSSPLSSNLNNFVSTNTCKKCLFGRFSSDGLQLLKNNNAVPPPVPSAGTINFENLFRNSEEEDPRRRRPSGSEDSNGNHKIIKVLNWQDDGDSAAVNRSVTPTVPLENLDNNTANLDDNVNDEVHDNQYEVIPNNNNVDQNEEQISDSEGECISFIQFVLECISYYEKAIEGHALPEKEKRYTVSETGENQMGLLQVEKPLYFVGGLDIHLWGGPRQLANKVLDLSKVKENIPGRSPVVVIKANLLRLQINRKLEIYELKKKNDKQKRSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPY6</accession>
    <name>A0A232EPY6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002867">
        <property type="protein sequence ID" value="OXU20420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPY6"/>
    <dbReference type="STRING" id="543379.A0A232EPY6"/>
    <dbReference type="OrthoDB" id="9972904at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU20420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33669" checksum="DC3A804EE6116412" modified="2017-10-25" version="1">MANNNLSNPSNTNIKSDLKEKLLPLKYTYIMSCVILMINGAFISIGSVIIWGNLRYFEKFVSYYTNTPILIVMIVGVIIIALSWFGIISAWLSYYCGLLMFYMFTSLLFVSTVAGWAYLYYVSDSNLYKKNLLHTLINATINYHFEEDAINIVQAKLQCCGVHSYADWETILGYIPGSCCESNDFCNYNNEFYVYNQGCYIALNRLIESYTLLLHLVVVITEGFFVLSISLSYYLYQKSYKDEQFISYTQRRNIELSQNNPRNNHSAYPVGLAAKSFIIKAMNNLNINCILNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQZ6</accession>
    <name>A0A232EQZ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002678">
        <property type="protein sequence ID" value="OXU20793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQZ6"/>
    <dbReference type="OrthoDB" id="7697589at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="258" mass="29830" checksum="0F30466F5F16A4B4" modified="2017-10-25" version="1">MEIEIHLNSLTLRIGLHAEADKIGYMQPKVLFGYWLLLQNNPGLLSEKIVYMSPSNIDWKIIQKIQQTNLQSERIVELLVGLDLSKASRQRRSVLPFIGQVSRFLFGTMDEEAQKDMENLMKLSSNDTLSNIPKSFDYYYKRDTLQVAKQILGQTVSQYKLDTKIITDVILLASQGAIHPRFLSPDLIYKSAELARETVPDPIFPSSDKIDTIIQLMKISDLTIIYSNYQLIYHLSIRFLIYKNTFYMKPPRFQSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERZ0</accession>
    <name>A0A232ERZ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002530">
        <property type="protein sequence ID" value="OXU21129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERZ0"/>
    <dbReference type="STRING" id="543379.A0A232ERZ0"/>
    <dbReference type="OrthoDB" id="7699714at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12548" checksum="3F190B89990B8C79" modified="2017-10-25" version="1">MPIFSFQPLDYFKVLLTAVNTLQRAEAATLMDFLENNKLLTCYQSGFRKNFNTQSALLKITEEIRMGVENGLLTVLMLFDFRKAFDSINPGILLKRMREMNFSDEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES68</accession>
    <name>A0A232ES68_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable oligoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002492">
        <property type="protein sequence ID" value="OXU21191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES68"/>
    <dbReference type="STRING" id="543379.A0A232ES68"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="51"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU21191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="230" mass="27131" checksum="828B956A8163A852" modified="2017-10-25" version="1">MSIARGVVIVFFHHISRWLEIDLRTFYVGKYIADHSDANTQDMSNNQRRNRIVWIDMEMTGLVVESDRILEVACLITDENLNIVSDEFHQVLHQSDDELARMNAWCQEHHTKSGLVEASKKSQEDERSVDKSLYNFLNKYIPKGRCPMAGNSVYMDRLFLRKYMPTSNEYMHYRIIDVSSIKEVVRRWKPEVHDAAPKKERNHRSLDDIRESISELDFYRKNVFNANSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESE1</accession>
    <name>A0A232ESE1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002440">
        <property type="protein sequence ID" value="OXU21271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESE1"/>
    <dbReference type="STRING" id="543379.A0A232ESE1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001963">
        <property type="entry name" value="Replication initiator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001601">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF106">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="746" mass="84510" checksum="3225A2423BF70064" modified="2017-10-25" version="1">MEVTTEEDAQAVLLESMEGTQYITIQRADGESLGKGVPLFALNGELISEGMVVDMINGVGADYNTGTQYYETEDLLPHVLTEEDRRLAAALVAVQLQQQQKQQQIHSHPNHDDPTLQDVAQLESLPPVNSYAIESIHEPNPPPVYPSIQTFKRGMHQVKPEFINVKCEDDVDISAESSEDAVPTPGPKRSLPHKKRIPRKLKQQSKKSAVKKESARSHQDSITLESSSKNQGNAFKCELCGNKFSGQLKFFEHLKANFIHQSFPPSSVLSTYPIVSFSKFHSHYEPVKEEKKLPNLPVNNNTAIAIPSITESIGHGVIEHTIEEFSEPEDIMEGIRDVVEETGAQIDDDDDDEIGEDALHDSNNSSSIWTISEVPEQIDQIEHIENIEQIEQIEQIEQIEQIEQIEQIEQIDQMEQIDQIDQIEQEELEEPSTINEEDLYEREPVKIVGQAKKKKSKSKKSNLDELTCPNCDRTFHHKNSLVYHMRSHSGERPHQCEVCGKSFFAASALKVHKRLHSGDKPYKCEDCGRHFRQWGDLKYHSTSLHSEQRQFQCEYCGKDFARKYSLIVHRRIHTGEKNYRCEYCNKTFRASSYLQNHRRIHTGEKPHPCDVCGKPFRVRSDMKRHMATHTRATNRDRLQNKTGTIKAQTNVSDASSDDSMNKANRTINEIVHELKLEVDPNTSVVELVGGSGEHESILPHVQTLDYAHAVASQAVAGTNDEGGRDPLEAVVGRTSDTLNFDMQVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET18</accession>
    <name>A0A232ET18_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002361">
        <property type="protein sequence ID" value="OXU21467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET18"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9454" checksum="DA0C0DC4C1E25071" modified="2017-10-25" version="1">MEFHLRVGRYCKYNLAGTSIVRSLIAHVTTIIPVARKTYQNSVLDLGFAKGSNPLCVGNGRGQKISNKICRVKEVDILFRTEDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET44</accession>
    <name>A0A232ET44_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002332">
        <property type="protein sequence ID" value="OXU21530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET44"/>
    <dbReference type="STRING" id="543379.A0A232ET44"/>
    <dbReference type="OrthoDB" id="9984940at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22086">
        <property type="entry name" value="F-box_EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF9">
        <property type="entry name" value="GH14043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="254" mass="29238" checksum="B0EAD9D33996DB9E" modified="2017-10-25" version="1">MFHDIYEENIHSRSYDLINKSKKSSMESYDSGYLSITPNSHGSSYHSNLPLYFTKKSYKTNQVSGYKSPSHCQQNSFKMELRSQKKSRMKPLEFSTCSRESLDNDNRATPDYTGKETVDIFKLLAEKSNHPRIITKILSYLNLQDLCSVTMVSKSWQRICSNDIKAEERRLKYITLKQCSKENIILLSKSKLEDLVQLTPKARYSRKGFLTAVSSNLLQVPKMNFEPDSPPVSPSKVIFNSFIKYIPASKEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETB7</accession>
    <name>A0A232ETB7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002327">
        <property type="protein sequence ID" value="OXU21546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETB7"/>
    <dbReference type="STRING" id="543379.A0A232ETB7"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24191" checksum="E015864B4DDB66D4" modified="2017-10-25" version="1">MKRWAGKVAVITGNNVCDNVWNRSSICSQRVNRSWSRSEKNGDGEWYERHQRTMKIPHEGMRYIVRREYRKCQCKRSVNFVGAVICAKQALQLIAENREEGYIVNMSSTAGVDTIKAPDKHFNVYSPTKYAIRSLSETLAHELKDTKIRVSSINPGLVKTEISAAANLQTDFLHIVPSLTSNDIADAIMYIVGLPYHVRISELTIKPTNDVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETJ2</accession>
    <name>A0A232ETJ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002272">
        <property type="protein sequence ID" value="OXU21663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETJ2"/>
    <dbReference type="STRING" id="543379.A0A232ETJ2"/>
    <dbReference type="OrthoDB" id="8192746at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011991530" evidence="2">
        <location>
            <begin position="19"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="894" mass="99416" checksum="1EE27A9397A8D72B" modified="2017-10-25" version="1">MEQLAYVCLLAFIGLGSSSEIEKVMPSRFEIESSINRTIEEVEKMIQDNPSLPKLSRADIVNILYNITAKDMHSIEDEALEALEKTRADYQRALMVVLPYKVKDSGENLDELYSKPPMVQMVADEASDPKKDSRIETVYNPSLFTQSNAHQSENLIENKYQLVTAHMRFGDSKKSKIEENKNFKSFSQVTTTTAKTLTDKKSESEPQKFTFNLEALDQRAEASHTSIATKRPIYKGTFSRYRTSTQKPPKLEIIYSTTPKTTPRTTTTTEARTETTTVPNKSTQNILSSDQWQYYAPPTTTTSRTLKPNDSPWKPMSPSKGFFLPTVSSDESDEPNFSILKMEDFEKVMQTTTTARPSPIFVTPSVTTHQKKVQSSIKNTGEGFKLRTTTTSSTVPPAPMREEVEQLLKSIGLQPMKPAKPQNDFKLNQNSLDALLKANFDNAKIKGTKFQTVKTDVLTTIKDNSFKAPTSSIKDGVKNLSPEIQLLFQQFGLQVPGSVGIPTTTTTTTTTSRPTIPTSVNSYTHFKPLPTAPVKDRDFRNFLARFGLGTGENRNQKAMQPKQVTKRPYLIEAVPENMQKILENIGLIRKAPKVEVDFEPNFEIQTQPPSFVELTTTPLNEHVFKPHEIEVNDKEQNEKIKNLLNTVRMVQEGKANVQDVQKVAHDLLQSTKSLASGPDPLKLEEILNNYRDNLKNEVKRQEEPTTTVASPTTEELDETALSSMATTDSSGSFSELSESSTSSGVDSKPSKADQSSSSSSTDDKVAKPSFFDTFDINAYLDNSTDTASSTETSSSSGSTSKPSVFDSIDAYIKMTASEDAAKNANPSISDLEESFGGSTPEPDPVIPTRPKTGLYFLVDWNTFLEVGEEGKEKVNLRFAPKVGDRTRFISVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU06</accession>
    <name>A0A232EU06_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002215">
        <property type="protein sequence ID" value="OXU21787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU06"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="71" mass="8053" checksum="A7C2E917710CC439" modified="2017-10-25" version="1">MKKKACAMSDEAPDRTVCIFVFYEPTYMDCNAIRVVNGLDYLSSAPFLFFPFAHRACAVTLDAARIITRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVC4</accession>
    <name>A0A232EVC4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002015">
        <property type="protein sequence ID" value="OXU22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVC4"/>
    <dbReference type="OrthoDB" id="7699053at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44885" checksum="B3456D167AB786F6" modified="2017-10-25" version="1" fragment="single">MQIVLSVGIVKGILIIAHEICKKTRGEERMAKGEFYDDRLFVINKKFLEILGRWPYQAKRSRIFLLSLYFVGILTVVVAELIYFVRVIRIKDIPKIIDCLPALIFTYGAMVMIFNSMIKFVEMRQILGKIEENWLSVRDAEEQAVLREFAEEGRFLIIGYTRNVNLNRMRYFNIPRGMTGFSVCIVGSLATYSLEPLVPQILDKISPLNESRPIKTFLEVEYLVDHRRYYTAIYLHNMQAAFWVIFTVLAIDAYLVMIVQHACSMFVVLGFAGLIESSFTVSLFLQLFLNMVVISVTGVQTISRRDQPGEMLKFSLSSVSVITRLFYISWPGQKMIDHSLRVRELVCGLAWYELPTGSRRLLLLMLLRSSRACTITAGGMFPMNFETYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVE3</accession>
    <name>A0A232EVE3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002012">
        <property type="protein sequence ID" value="OXU22307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVE3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="7002" checksum="0DA54AF09858E0B9" modified="2017-10-25" version="1">MKNNDCCLEINFDTQHRPILNMKNAIDLSSSKENSSFVWMCTDLQVMLVLYNWFVSFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVK9</accession>
    <name>A0A232EVK9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002001">
        <property type="protein sequence ID" value="OXU22345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVK9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="9418" checksum="35B801CA9C21A24A" modified="2017-10-25" version="1">MASSLQEHHPPLGAVTKHLAKVFGIHPRPLDIHTSCPYNTSWLDEVLHSHGSIDRGLSLLDNTACLSLCFAASSASYQLLGHGPRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW33</accession>
    <name>A0A232EW33_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="5 19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_008035</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 19"/>
    <dbReference type="EMBL" id="NNAY01001922">
        <property type="protein sequence ID" value="OXU22562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW33"/>
    <dbReference type="STRING" id="543379.A0A232EW33"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="161"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU22562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="282" mass="31878" checksum="96BE3CA5A29D8875" modified="2017-10-25" version="1">MVYDNRHRTLLQAIMQGGAVLEHDASLICTKIFGERLNVASVAQSINEKLAPLAMAMKSGICEMSGEKYWSIVGTTHEESITVPSQFNTGQRAFLREIYSEIISADDGCISSTDCLNMSTTLDVKLSISDADIFLKYLTKGKWLLIKNGYVFMGVRSIVELMPYFRATYQDNFHNCTLCKEIVFHGQKCENCDKVFHYYCLAKYASMQNESKCPQCRHTLDTSYTSFVADESTTSQVANGNREEQPMDVSEDDNDNGDEDDDDSENSPPMRRFSKRTRTQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWG1</accession>
    <name>A0A232EWG1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001872">
        <property type="protein sequence ID" value="OXU22676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWG1"/>
    <dbReference type="OrthoDB" id="7694231at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="479" mass="53443" checksum="8264CA477E4C79E1" modified="2017-10-25" version="1">MSKRKLVTPAAQLSCSSSFVAGDTQSPTSLVQSAHRRLQYSQLPVRISSKRSISSQPQQGKLASSLRKFTPKRGASEKRSDDAASTAKFVAAAASSGSPSARKSLSLSDLTPVCNVGLGDFDLGELRLESGSNSARLMEDNNSSERRTEETLSVEGCNLMTWPLSSNHRLHQETTESKAASVVCRTLAINALRRRRAEVAKLKSEFAQQIDLLQLQIVVLRRLLDNENARVVSLAGELHKAKAQSDELAKERDSLKIEKESAESEAQRQRELSEKRSVSEENLRNELRSVRDQLDALDKQISKDREKLLKLREDKKILLEKVSANDALVARADKAEALLEDAETKLVERIALADSLQEELVRVSDSLEQSEAELRKMEEENAMLEERLRKSEETCRVLRSRAEDLESELFNQESNIKHMLASYAAAKAEVLELQEQLVRRSQESCWSSKVLQLAGSFVRAPAVIFRTLSFFLTGIPLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWR6</accession>
    <name>A0A232EWR6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001828">
        <property type="protein sequence ID" value="OXU22786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWR6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="38" mass="4407" checksum="3B3B3BC0B303832D" modified="2017-10-25" version="1">MLSRVYTRHGFRITIRRRVEECNTVAAVARRQSVCLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXM2</accession>
    <name>A0A232EXM2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001742">
        <property type="protein sequence ID" value="OXU23059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXM2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="187" mass="21113" checksum="D3FD43581F29C3EA" modified="2017-10-25" version="1">MYKMIRFVTFFLVGQLENKVDELIGDCQSAPRDVGRIAKRAKQLKVLLEELREMYEKGNLEEESYQDAVDYYQAWHKTPEKARRGARGRLLKDAVLASAGSKRAIGESQVQQKQSSRRDTSESGAKQDVRESHGENPKGYEPEHHLNNSAGNQANKKCRCPPKTGKSVYCGSRKSIAGPWTVRKGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY70</accession>
    <name>A0A232EY70_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001710">
        <property type="protein sequence ID" value="OXU23158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY70"/>
    <dbReference type="STRING" id="543379.A0A232EY70"/>
    <dbReference type="OrthoDB" id="7701067at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="348" mass="40739" checksum="17F7314EBA314F22" modified="2017-10-25" version="1">MIKKFNLPLPYPFDPKIILTEEDENIISEQEGRIIQKAKIPNEKFNEIFKKQPIQIIDFYTDGSKSEDSEYTGAALFSPNINLEKKFKFTKLASIFTAEAYAIMQTLIIIKNDDIPKTRIFTDSKSVLQAITNYSPLKSKNTSYLILEIKKLIYEIKEKNLKTKIYWIPAHKDILNNEIVDKLAKEATKTGDQINLKLPYTDLFEEIKKAEHKSFRKKLDSQKNIKGVQYFQNYYEESSKPWFYNSIVQRYHITTINRIRANHYSLAESLYRKNLVNSEACKCGFISEDIEHVITECPLYNKERTTLIKKLKKNKSTFPINLIHIFKNPNSKEAKFITEFLKTCKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY84</accession>
    <name>A0A232EY84_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001661">
        <property type="protein sequence ID" value="OXU23283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY84"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="68" mass="7949" checksum="F055E42B1CD32978" modified="2017-10-25" version="1" fragment="single">EIHKLKEKVKSTTDLSNCQLEITESAMNKIKKLETERAKLESKVLKMEAELTSYELSQEILRQDKNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYN2</accession>
    <name>A0A232EYN2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001613">
        <property type="protein sequence ID" value="OXU23419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYN2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646954" evidence="1">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="10153" checksum="44F3CF2EAE980776" modified="2017-10-25" version="1">MFFRYFLALCVVALFSVAIHASAEEEVVDSTQVEDRANPAVKVVAKIIGSLFTGAAASCLGEAASNCKSHWKNPGKAMSCAKNFLKANKGRCAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYR8</accession>
    <name>A0A232EYR8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001609">
        <property type="protein sequence ID" value="OXU23440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYR8"/>
    <dbReference type="STRING" id="543379.A0A232EYR8"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001228">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001038">
        <property type="entry name" value="WD repeat domain 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="696" mass="77453" checksum="9C411CDFE652E34D" modified="2017-10-25" version="1">MDNSSKKTGVGFGKISFKLNTKSIDDNAPATSKKDSESGSTNSGFGKIEKPADTSKVHSTLGFGTFGKKAVEANAKVIVEIRPEDEEENEKLQSLMGMSSFGKKARCFDVQEMMENIKKTIVTTKPVEKKADSNEQEKDSTDKTESDNDDDDDFIGPPIPTAVGETKEEEKTKTKTKSKKHNSDSDDDDDDDDDDDDDEDDDEKETDLVSRIPCTHQVSMTHGNKAVTAIAADPSGARLASGSVDYDLSFWDFGGMDASLRSFRTLQPCENHPIKCLQYSMTGDSILVVSGSAQAKVLDRDGFEKCETVKGDQYITDMARTKGHTASLNSGTWHPFTKEEYLTCSQDSTCRMWLLHKPKAHKALIKCRAQNGVKTVPTSCTYSREGTVVACGCVDGSIQMWDHRKNFVNPSLINRNAHDSGNDISCLSFSYLGNMLSSRSCDDSLKLWDLRAFKNPLFTASNIFSRYDSTDCMFSPDDSMIITGESLPKNQQAGRCLFYSTKTFDLVHEIEVTNSHVIKTLWHPKLNQIFVGCGNGIVKCYYDIKRSLRGAKLCVVKQRHKQKHVEMMPTQQIITPHALPLFRQDRPKSVRKQMEKDRLDPVKSRRPDLPITSGQGGRVASSGGTLSSFVIRNLGLSKRIEDDQDPREAILKYAKVAEENPFWITPAYKKNQPKQIFQTDGEDESSGEPSSKKPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZB5</accession>
    <name>A0A232EZB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Eyes absent homolog</fullName>
            <ecNumber evidence="15">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_007461</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the HAD-like hydrolase superfamily. EYA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01001475">
        <property type="protein sequence ID" value="OXU23836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZB5"/>
    <dbReference type="STRING" id="543379.A0A232EZB5"/>
    <dbReference type="OrthoDB" id="167668at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001240">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02601">
        <property type="entry name" value="HAD_Eya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028472">
        <property type="entry name" value="EYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006545">
        <property type="entry name" value="EYA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042577">
        <property type="entry name" value="EYA_dom_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038102">
        <property type="entry name" value="EYA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01658">
        <property type="entry name" value="EYA-cons_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190:SF16">
        <property type="entry name" value="DEVELOPMENTAL PROTEIN EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10190">
        <property type="entry name" value="EYES ABSENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 15" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628472-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU23836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="545" mass="60929" checksum="DEC6C61407D0E6CF" modified="2017-10-25" version="1">MSLAFAEAEVKNEVQDCPETESVPGGELYIDENAEEKEHEYPDSMEKADYGSLYGANPFYNRYAASYNIVGMQKLTKLLDFAQPVQLAVMREHSSLEGLVVPAELVSRLLHGAELDDAVLVLPGLQQRLRQLPHRPPEHIRSLSGMYTRALIVSARFAYSLGRSLQKLDYTAYSTSLYGNDRVPLQYSSYYPMPGYHPTPTSFNISNLNFVDSTKSALTLDATAHDTNDLTARETANVEGGSAKPCKRGRRQSGSGNSIGSADTTEAGPDRIFIWDLDETIVVLQSLVSGQFATTYNKDPTILAQLAYRMEEIVFYLADTHFFFNDIESLRSQECDQAHIDDVSSDDNGMDLSSYNFANDGFHCEAASNGICLPSGVRGGVDWMRKLAFRYRKIKETYCNYRNNVGGLLGATKREHWLNLRAEIEQQTENWLTVAVKCLSLIGKRSHCVNILVTSDQLIPSLSKVLLFGLGGLFPIENIYSANKTGKESCFGRIMARFGRKCTYVVIGDGSDEEAAARFHHFPFWRIKSHSDMQALYNALEMDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZC4</accession>
    <name>A0A232EZC4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001538">
        <property type="protein sequence ID" value="OXU23657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZC4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="120" mass="13826" checksum="2EDA29F225E6EE70" modified="2017-10-25" version="1">MSARNSLQSQALYSGWEVRKSRGGLDNSTEQGEKAGKGALEIWNTIWDAERERKSIWKKIQDRLDSMDHVVSNASNIHKSVKSDPSTIKIQVKRLKREQEELEKSKENLELMLSKAEDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZH6</accession>
    <name>A0A232EZH6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001474">
        <property type="protein sequence ID" value="OXU23842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZH6"/>
    <dbReference type="STRING" id="543379.A0A232EZH6"/>
    <dbReference type="OrthoDB" id="1868004at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130">
        <property type="entry name" value="34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33235" checksum="DD890427FC89D595" modified="2017-10-25" version="1">MEQLQTALSTLKVLRSSVGQVFYSLANGIRADHGEENKENKYLLELQELLTTVGTNLRDVEQAVNSLNPPPGPFNLGNTAYLAQETTQDRQALYGTLVNVYKWTDKAHEYSNVAHQILSQNSLKRSSMSSNRAKRSRVQAGAHNSPPQQVDQVMASFDRLYSDMSITITRPYTSNAVIHVTLGHVLKAIIAFKGLMMERVVIKGYNEELDLWTESRYKVFQRVTDHAHAAMLHFYNPNFPELTLKSFFAWFHSFISLFNDPCKRCGLYLYGALPPTWRDPKSLGPYHFECKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZH7</accession>
    <name>A0A232EZH7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_016727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001493">
        <property type="protein sequence ID" value="OXU23791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZH7"/>
    <dbReference type="STRING" id="543379.A0A232EZH7"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="192" mass="22325" checksum="2FD34416CE95C510" modified="2017-10-25" version="1">MFGKEAIKLVGELETSEEIKPFNATIFRQVLEEIQSLYEENSKDVNAITEENPAPKNTLIVRHFAMNRNKRCLLAYLYHRMRRLRQARWELGSILPPEITTNLINPEIQWFQAYNKILATYMRSIGDDGLNITNDVQPPKSLYIEVRCVQDYGKFEFDDGQIVNLKPNTYHLLPRAQCEALIRQGILEHVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZX9</accession>
    <name>A0A232EZX9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_015932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001431">
        <property type="protein sequence ID" value="OXU23994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZX9"/>
    <dbReference type="SMR" id="A0A232EZX9"/>
    <dbReference type="STRING" id="543379.A0A232EZX9"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="5">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="207" mass="23843" checksum="231EED422DD7C851" modified="2017-10-25" version="1">MPKKFVGENSKAVVARARKAAAKEAENTRKAQEAEDKAWQDDDKQLQKKKQKQEEMEKKRLQQLQKKEEAKALLEKELSSIKIGGKQPAAKLTRAEIVAATEKRNQVAQKKKEDEKPIEENLNRIVLEGETAHGIDEALSVLSSKDPEIDRHPERRMKAAYLAFEERMMPILKDQNPTLRLSQLKQLLRKEWMKSPENPLNQRIQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZY5</accession>
    <name>A0A232EZY5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001478">
        <property type="protein sequence ID" value="OXU23827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZY5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="12978" checksum="AF01357587C538D8" modified="2017-10-25" version="1" fragment="single">MFLVRRNCSAETFKAKNKSSQFAPCQTQRSRAKSRPICSTSIEELALFSTGVNARGVKWSGLKGKFYDGIPKVRGEANLFLLNLYICITHDDGNECMGLSHCCADVTHLEQKNKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F091</accession>
    <name>A0A232F091_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001421">
        <property type="protein sequence ID" value="OXU24032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F091"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="147" mass="16141" checksum="CF98E2629D97F8F4" modified="2017-10-25" version="1">MPENVLSWPKYIHQKDYCSHYTDAHAYTLSLALLSMEAQLFSPNEQRAKSTTSYTQSSVLRCGIPALGKRVKAIYTHAGDVVVGADALLEKTVPDFPGEDRGTLALVEGYLADYLGGGHSGLAATDGPRPYRARLVLNLYNNRLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1D9</accession>
    <name>A0A232F1D9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">L-tyrosine:2-oxoglutarate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_008809</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001368">
        <property type="protein sequence ID" value="OXU24218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F1D9"/>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000048">
        <property type="entry name" value="tyrosine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="13" id="KW-0176">Collagen</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Collagen IV NC1" evidence="20">
        <location>
            <begin position="1545"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="184"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="614"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1171"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1453"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="910"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1187"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1400"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1465"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1496"/>
            <end position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU24218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2181" mass="222977" checksum="3E03FE79E8DAA4F9" modified="2017-10-25" version="1">MPCVTYSHLHKVRATARLRNTYNHTQWEARADDVSQRGDVPGTSDDYDYPENNYPRQPQPPPVHNQSGNNGYDQNRQTWMSYEERQRYEEQMKWEERRRLEERRRQEAASQQGYGSGSESGSRQESQDRYGENGYPSSYKVYPAPGYNAQKNCTGTGCCYPKCFAEKGSRGPPGLMGPVGPKGERGFPGAEGFLGPKGDKGDPGPQGQRGVRGERGKMGLPGHAGQNGVPGIPGAAGPPGMPGRDGCNGTDGAPGLHGLPGEPGPRGLPGTLGDKGDKGEAGHCGLLLTGQKGEPGSDGVQGARGIPGPQGYPGQPGQKGERGPIGFTGPQGIKGEKGNMGVGFEGKKGDKGDKGEVGPPGESVTQPFESGGQEVIGPVGPAGAKGDKGDTGFYGQKGEPGYVGDNGVPGLNGPKGEKGLPGAPGIRGGKGQPGPPGEKGPRGYPGAIGLRGSDGYPGAPGPRGPVGPIGGPGLAGVPGTEGAPGDKGAKGEPGLAGFPGEAGPRGFTGPMGPPGPRGPQGEKGLSIVGPAGMDGINGRDGAKGQKGEKGYGGSRGRPGDSLEGIPGAPGAPGLPGEAGVPGRDGAPGFPGLPGEKGDIGGRCTQCLPGIKGIKGDRGLDGRDGLPGARGPPGERGFPGEPGLDGLPGTIGLPGPEGPIGEKGRPGSPGFPGTKGDTGERGLPGSDGIPGRPGFSGQKGEAGLSIKGEQGDRGRDGYPGQKGEPGYTGLKGEAGQCPPLTLKELSVGPPGDRGPKGEPGLPGYDGQKGDRGFTGEPGPPGPIGPVGAPGQTGPRGLPGPRGEKGNTGPMGFPGEPGLTGPRGLPGFNGPKGAKGEAGISMKGSPGLPGPQGPKGDKGLSGPVGKDGPVGYSGLPGTPGEKGDVGEPGLNGTPGSPGAKGDTGPIGPPGPQGIMGTPGTDGLKGEPGLPGEPGRTGLPGLPGVKGDMGVPGIDGAKGFPGRRGPPGLQGRPGRDGAPGLKGDRGEKGLQGFPGMPGMDGKPGRPGDIGPKGDIGFPGEPGPMGLTGLEGEKGDRGDQGYTGQKGEPGQVSEKGQKGEPGMPGIRGPQGPPGLDGRDGEKGDAGIPGYGRDGPTGDKGEPGLPGRDGIPGPKGDRGDVGLSGLPGQKGDIGFPGPVGEPGIPGLDGIDGMKGDVGPPGMAGFPGLDGEVGLPGRPGFDGPKGERGLEGLEGPPGYSGPLGEKGDRGPPGLTVNVKGEKGEPGRPGFPGLDGEKGDIGLPGPVGFVGEKGDKGEYGTPGLSGLPGPQGEKGDRGPFGPIGPPGLTVKGEKGLPGLHGKQGRDGYPGLPGAKGERGLPGLPGLKGDAGLPGPFGPPGMKGDMGLPGPTGLPGRDGPSGLDGIPGAIGDKGDKGDQGPPGLFGAPGQKGEPGLPGRDGLPGIPGEKGDRGWEGREGLQGLQGEKGDRGYPGVDGQMGIAGFDGEKGDKGEACLALPSERGEKGDRGLPGPVGPPGPPGPKGDAGQPGFPGMDGPKGMTGFTGPPGSPGLRGLPGLQGPPGPTGLTGPIGPPGVPGENGLPCEAAPDYLTGILLVKHSQSQSVPECERGHVKLWEGYSLLYTDGDERAHSQDLGYAGSCVRKFSTMPFLFCDVNSVCHYASRNDRSYWLSTNSPIPMMPVEETAIEEYISRCVVCEVPANVIAVHSQSLSIPECPDGWSGLWIGYSFVMHTGAGSQGGGQSLSSPGSCLEDFRATPFIECNGAKGHCHYYSNEFSFWLATIEDRDQFQKPEKQTLKAGALRQRISRCQGWNVQASLIAKRTHNPIRSIVENIVVEPNPEKQMIALSIGDPTTFGNLKPAREVIEAVQESVESQLYNGYAPSTGYEEARRAVAEYSSTDDLKVEAKDVILCSGCSCALDLCITALAREGQNILIPRPGFSIYRTLAEGLGITVRSYNLRPELGWEIDLDDLEAQIDESTAAILINNPSNPCGSVFSREHLLDILDVAAKYYVPIIADEIYEHMVFPGRRFHSLASLSSEVPILSCSGLTKRFLVPGWRMGWIIVHDRQNILDKEIKKALQCLSQRIIGSNTIVQGALPKILKNTPQRFFDNVVQTLDAHATLTYNYIAKIPGLKPIMPDGAMYMMVHIDLPSFPEFNTELEFVQRLLAEESVFCLPGQCFDYPSYMRLVITVPQDMLEEACLRIQDFCARHHVKNYLRNSINSVEIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1M8</accession>
    <name>A0A232F1M8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001244">
        <property type="protein sequence ID" value="OXU24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1M8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="36" mass="4018" checksum="A51DFC5AC0B7D0EA" modified="2017-10-25" version="1">MAATYTRVSQYLSFIDTVINGEMSGEVRFIPVHVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2X9</accession>
    <name>A0A232F2X9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001174">
        <property type="protein sequence ID" value="OXU24869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2X9"/>
    <dbReference type="OrthoDB" id="6160353at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="308" mass="34743" checksum="21ACAA7588E69D53" modified="2017-10-25" version="1">MQEFCPQCAKNGQENKIRAFQLNHTEAVLMCSSEECIWPVGHQKLTFINRLVGKEHSSNWEKLVRAHIKTEHDRLLEFQPYTPPQTPSTFPDIMSIPIEDIIFLPDDQQFPNSFIKPCSTIADSTASSKVKPKPKVISIETVTNMPTSLADKPKIIKHGKYTLGPPQIRQVKIEPKETIKVLTCPRKIGQSYKKFSLTDLSNTEDKVINKVPKSNVIKVEGAEIIVKDCLDELSTITNKVESSNVVSTIGDTSNPKDLDAETIDDDVLDIDLDEFFEGFSNEIEGTIKSEIDNSNEFNFGYEYDSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F326</accession>
    <name>A0A232F326_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_008190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001147">
        <property type="protein sequence ID" value="OXU24982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F326"/>
    <dbReference type="STRING" id="543379.A0A232F326"/>
    <dbReference type="OrthoDB" id="5977959at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051066">
        <property type="entry name" value="Trans_reg/Corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089">
        <property type="entry name" value="REST COREPRESSOR COREST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16089:SF40">
        <property type="entry name" value="SUPPRESSOR OF ACTIVATED EGL-4 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="743"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="850"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="430"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1052" mass="114658" checksum="1F4741FF7D624A31" modified="2017-10-25" version="1">MRLHGGYFKKDAENKKSEKKEVVGPPLQTASVSVRALIEEKIIQKRTTATDANAAAAAAAAQQQQRANAVSFASQQTTSSSSTASTEVQAQQQPQQQQQQQPQQQQQHVMGKMNFAVPAPPPLAGVEKTRRLSDGEHFRQPNVTIAGHASSVQKQLQEAQTQAQAQALADMILKGTTKMAVKRATSDPGQRVQLAYQSTTNAQQQQQNAQQQQQPTITESFTMTGYPEDGGYFSPSLQDEVFQQVTSVPDSVLLHATQLDALQFQTSSLLQDQSGNETLPDINLEERFSSQHTVNPDLQALVNSPLPDSLAEFSTYGANYNDGSHTLPSQSPLPSPLTRHDSPSFTYPTPPASQEGLLSGSLPLLSPQEDSDAVHSVSSPLSAAFYSTSMSSVAAIEEALSEVLPDEADNDGADIYGSGCPNPHSPLPSPLSATPAPSPLSSLPPSSVSSPGPGSFTTSSFPMSPHHTLQSQMMPNSEDPLLSSSPKDFGAGRRKFEFQSYKLITNQNLVDFGLGNGSVAGIVVDNNGEFKLIQTAGLQKANVYVQAGALSPALAFRKEICQVGPKLEQGNINVNVVNGQSMNLQNHIYQQTQVHQQAINPAKFLIQINQANKPNLKHKAMSVPAEQVKEEESLDEDVFLSPSSVPMTASGSPARHYKKRPRLDGPMHCNSGTSSCSAINGSHSYPSRLRRACDRHWDSSYTPPPILDPSRPGSGLYARLHQNERDCVDFSSDDSQGNDGPPPRINIGTRYQATIPQMVENECERLAATEPEMDHLLWDPGIESALTETELEMYLQFACCAAVPGGGRNKEYALHLLHMCRGNIREAMLKLMRPTPSLTSEHPLLSYECQESDRWTSHEMDLFYQSLLKYNKDFGAIAREIGSKSTKQCVQFYYLWKRLCPDEYKRLRLRYGKPKIQSDFGRDGKDTKDLCDAIAAVAELDFSEGKSILHRTLVTILWMQTTNERENSATLTTSEGELRLFAYDCQDSFSGSVTVTMAGSAQVARAPSCTGKAGGATGYATVDHTNSQTHTSTEQQLPAPTPLHYPCKICGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3T9</accession>
    <name>A0A232F3T9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001030">
        <property type="protein sequence ID" value="OXU25421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3T9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556714" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="6738" checksum="6ECA53946C600340" modified="2017-10-25" version="1" fragment="single">MLRYSTLVLLLALVGMCLAAAVPAPIPAAANDDLETAASARAQFGYGGYGGHGGYGHGGHRHGGYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3X6</accession>
    <name>A0A232F3X6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001090">
        <property type="protein sequence ID" value="OXU25170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3X6"/>
    <dbReference type="STRING" id="543379.A0A232F3X6"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000003">
        <property type="entry name" value="vacuolar protein sorting-associated protein 45 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="571" mass="65487" checksum="1A18510FD2A6F0EB" modified="2017-10-25" version="1">MNVITAVKYYVAKMTEESGPGMKVLLMDKQTTSIISLVYSQSEILMKEVYLFDRLDAAVRNEGLKHLKCIVFIRPTEENVRLLCNELRYPKYGVYYIYFSNIIPKTDIKLLAENDEQEVVREVHEFYADYLAISPHLFSLGINTCSRGLNWEPAHLQRTVQGITAVLLSLKKCPLIRFQSSSDMCKHLAEKIRYVLTQESNSFEFRQESNPILLILDRRDDPVTPLLNQWTYQAMVHELLTIHNNRVDLSNVKGISKELKEVVLSAQHDEFYAQNLYLNFGEIGQVIKDLMEEFQKKAKKHQKVESIADMKNFVETYPLFKKMSGTVAKHVTVVGELSNLVGTYNLLEVSELEQELSCQSEHSPQLQKIKKLINDSRVRDIDATRLVMLYALHYAKHTNNDIAGLCSMLKKRDVPEKYTKLVYSILDYSGISTKQINLFDREAVAKITKKLFKGLNGVDNIYTQHTPLLAETIEDLIKGKLNVQTFPYLGNTVLTKKPQDIIIFMIGGTTYEESLAVHNLNKQNPGTRIILGGTTIHNFESFCDEIQSAMVGAIARYRPKSVRERNERDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4D6</accession>
    <name>A0A232F4D6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative sodium-coupled neutral amino acid transporter 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 38 member 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013033</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Putative sodium-dependent amino acid/proton antiporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001056">
        <property type="protein sequence ID" value="OXU25313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4D6"/>
    <dbReference type="STRING" id="543379.A0A232F4D6"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="13">
        <location>
            <begin position="56"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="542" mass="58716" checksum="F6B68BDA67C74600" modified="2017-10-25" version="1">MESSEPKNAMNEKSYILDNSRKPFEDGGSLGSEDSFDDMRRLVREDEPENSGKFTSLPLASFNFINSIIGSGVIGIPYALHQAGFGLGIALLVIVAILTDYSLILMVRSGHLCGEMSYQGLMRASFGRPGFYILTALQFIYPFIAMVSYNVVVGDTVTKVLIRVTGLDPDSFIVKREVVIFLATLLVVIPLCLYRNVAKLAKISFLSLVCVGFILLAIFIRMDSMSSIVTKAYNLLRPSHPDSWKFGNIAGIVPAVGIMAFAFMCHHNTFLIYGSIERATQEKWDVVTHWSLFTSFLIAAAFGIAGYATFTGYVQGDLMENYCWDDDLMNFSRIMFSGTILLTFPIECFVTREVIMTAIRGTDEVENHDAYIAGSDRKYLIITMAIISVAYLISMSTDCLGIVLELNGILAAVPLAYVLPALCYLKLEEGSLLSQKKLPALALLVAGVFAAVSGLLLLIFNNTSAASCVHGQIMSYCQSPNSTDVTSTTFKPSSTTASSILTSLLTSPASATTVTTTAATSAATSTLASTTTSTTTTTTLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4F8</accession>
    <name>A0A232F4F8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001046">
        <property type="protein sequence ID" value="OXU25360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4F8"/>
    <dbReference type="STRING" id="543379.A0A232F4F8"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1082" mass="121693" checksum="7731DA7FB7713C28" modified="2017-10-25" version="1">MEEIILKLLVTDTAVIQQATAELRQAFKNPESTRALYQLIVTSNNLQVKQYAALLLRKRFNKAKYWAPVPNPIKEEFKQVLQQALVNETEKPVKNGIVQLIGVIVKHELPHNGWPEVLQFVRHLMESDEFPKQELGMYTLSIMTEIAPDAYLPHVQTIMELLNNVLNKFTDLANPVSCYILDIMLHLVSLVEGNQIMVNAYHQLLPRVMQIIQALTTVDQEKAAKGFELLDELCESAQSVIAPHVKNLVEMCLTIINNKDLDDDLKMKAVVFIGWLAKIKKKAIVKHKLVEPIIDTLFLQMCSKPDDEEQEIYFSGENDNTPITSSTQTLDLLALHLPPEKLVPYMLKHIESGMEGTDIYVKKASYLSLAVLAEGCSEYIRNKYLESFLKCICQGITHASPVVRNAALFALGQFSEHLQPDISRYADELLPILFQFLSQICNQIRQEKKDSPSADRMFYALEIFAENLNEGLLPYLPTLMTILFEILDDPNSPVHICELALSAIGAAANASKEHMLPYFEKIIGILQKHLVVENQTEETSCLQIQAVDTLGVLARTIGEQNFAPLAMKSLELGLNLLKGTEDPDAKKSVYGLLASISTVMKEEMSSVLPVIAEYMINSVQSSEGIVTRYNEESEYLVYEDLSESDKDEEDIENSDNEDDNDDDDDVIGYNVENAFVEEKEEAILALREIAQHTKGAFLPYLEKSFEEVFKVLNYPQEDIRKAAIDALMQFCLNFSKIETSEGAAATQKALSMFIPKLSELIRLDEERSVVMQALDSCAELLEHLKSDVIIGAGHKEAIMNCITDVMFGRTECQDQDEAGGEGEDEGEAEHDELLFECAGQVLTNFGKALTPEDFALYLQVIFPVLIKRLKSKNSDSQRSFSIGTILECFPSLQHQVVGFVPELFPIFVKFTNDPCDEVRSNAIFGLGELALHGKELIYPHYAEILQVLSNAIARESNAGARDNIIGAIARLIITNHSIIPLDQVFPVFISHLPLREDLEENKTVFKSILVLYTNGHAVLRPNVNTLLKIATDIIQQENTDDETKNLIAEFMKLVQRDFPEEWNSFCGQLTTESAAFVMRMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4T1</accession>
    <name>A0A232F4T1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_003987</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001018">
        <property type="protein sequence ID" value="OXU25473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F4T1"/>
    <dbReference type="OrthoDB" id="6411962at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEA" evidence="13">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="1352"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="918"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1034"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1103"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1601"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1613"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU25473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1632" mass="180954" checksum="82012FCFF4B4A131" modified="2017-10-25" version="1">MLIVIAMLVLVAVLAIAGLALWMGALRADTKNAVVGFVGSFRITRGEKYNPMLKLNTSMVFREKEQKYKNIFELLFRRSVLGPSYRQAIIDKFENNTLKVFFRLYLDRRKIPRSITNVEDTVEDIIAKETYSVNSLFKDMELDLTSITVKRLNAEGAANPKPAPSQQRNTMITKNGILRPNRNISLITTHPKTNHNVKSKPEPIDVSDPESEIDFSNIPTIKGTYTAIKLNATGSRRDEVVVPSGTTTTTTTTTTSTTTTTAAPSRSSSTTTSEATTTVKIRPMTLSSSGTIETGFHEFKEPDLETSPWRPIIPPYLNSDHKLGPGVVTTAAPSVVTQKDEKDDGQSAVDKLAEIKKIVVETSPATNTLVPPLLIALDDEDSVFPHDRVVPQEMVNFRVNDKFKNKPPASSAVSPIYEESTENGKPKIEVSGQLPPDTYDLRLKASPNGQPIPPVQLPGVIKTDDEIKYTSVEPNFPGFDEEDEQPTILTGIGVAEPVLDTELDLESRNRYSEIMADEPDEKLNSPLDKLNPHQPQQNQPVYTSYKTPDLMGGSKPPLVRVPGTLKPFSHTIPVDKISPAMDDVPAPPMDFMDPPMKIEKPTRGQKPIPNLERIVEIETFVKDVTELPANNSNSTSNSDSTIVETLIDDEKVLKMTTTEVMSEFLHPEFNNGEKLVMAGEGSGFPSRNTTFVKVDMIKHVPGVLANTSEDSVQMRNLTSEDSSQPTTTTQQTTKNVYNDTLKANVVIDLVTLAPVKSNTGVGRPIRPRPKRPQPPVESKNRTAAPVLPVAYISTVNTSEDTVLLERLFGLQSADSDSKRESPEQQQRDFAKDPLPETIEQIVEVVTSISTKVSSSVKGDQMILKLVITNSTAEPDHTPPNKISTVTTTSTVTPNSDRKIATAQDNQFLVDNLRKFAAVRTGNEPATKKPKTESAPPPPMPTRYKPDNLVDLEKLKQIADVVARENKTVTVPKETTVNFALSRDGVPVMTKTLTKAEERNDKMISTTEENQTSQAQICHGFQCGDGKCLSISGRCNMLSECANSEDEANCTCADFLKAQLLHKKICDGTVDCWDYSDEADCDWCRDGQFVCGNSRFCVDQSSVCDGIRDCPYGEDEKKCAALIDDDLQLEDSSKPSAQVYREFFTSGNEDIFEDIDRKDDNVEENHTTEEVLEEELPEGNLTDVVSSREISSSKARGNNNLVGSIRADVKTEGPFAKYSNRLEVNNFNDKGFLNVRKNGQWGKLCLSDADSLLQRRQLSWTIEDLGRAVCKAITYQDFDKVEKVQEDSPSLDKTYYSLSLNDKSTDRTSLTLKKTKCQNGQVLKVKCKNFECGIRTQVPSQAREWPRTRHYRIVGGGSSSAGSWPWQVALYKEGDYQCGGVIVSRRWIVSAAHCFYRAQDEYWVARIGATRRGNFPSPYEQVIRLDYIILHPDYVDISFVNDIALLRLEKPLTFSDYVRPVCLPTSEPKIGTTCTVTGWGQLFEIGRIFPDTLQEVKLPIIPMEECRKETFFISFNTSGMLCAGVQEGGKDACLGDSGGPLVCSESDNKYTLNGITSNGHGCGRKGRPGVYTKVHYYLDWIERVTSRTDIPSTVTSCKGHRCPLGECLPKSRLCNGFLECSDGSDERNCPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4X7</accession>
    <name>A0A232F4X7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_011081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000922">
        <property type="protein sequence ID" value="OXU25886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4X7"/>
    <dbReference type="STRING" id="543379.A0A232F4X7"/>
    <dbReference type="OrthoDB" id="2306477at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18501">
        <property type="entry name" value="BACK_ANKFY1_Rank5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15728">
        <property type="entry name" value="FYVE_ANFY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000104">
        <property type="entry name" value="Ankyrin repeat and FYVE domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049764">
        <property type="entry name" value="ANFY1_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049763">
        <property type="entry name" value="ANKFY1_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF191">
        <property type="entry name" value="RABANKYRIN-5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="688"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="733"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="766"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="834"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="869"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="902"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1007"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124206" checksum="E21FF04D031A988E" modified="2017-10-25" version="1">MVVFAEDSSDSQKWQQHLALLREQYVNLYNNYTELQQKYALATAEKEDHGFVGRLLSQISALYEEQRYSDVTVVLRDRSIPVHKFVLAARSDTWSSLPEKAVLDWKNLDGNVGSVLLKWIYTDIVSQDQLTLELMKAASGFGLTELVDRCEKYLIGSVKLQDCVRLYTIAEELGTKKLRDHCSSLISCHWDDLSGEDFKEMPGPLLYQLLKTKSEYPLHSAVRLQREDVVFLYLVEHNAELPEAVNALDQRGETALEVALKSRQPSLARTLVEHRADLCAKDARGLTLLHSAILKADSYAAEFIVEQLENNGGKVLDQPNEDDGKTALHLLASHTSQDMLAVAGRLLKAGLEPNAQSHDGWSPLHCCISQRNEALLELLLDSESIEVDLRTKDGDTALCMALLLAEPSFESGAAKLLARGAAPNPRYPGDEADTLMHRLARELHEDAALFLLEPCDPDQIKASKTNKKWRAEADTLESRNREGWTVLHEAARSGLSRLCRRLLERSPSLLASRTLSGDTALHLAVAHGRLEALRSLLDAAPDNEKRDLLTTKNKDADSPLSLALGAVPKDKQVLAALIQAGADLEQRNEAGHTALHQAILKEDSASAIFLLEHGADINARSLSGETALQLSVHCRLGDVVEALCRRGADTSVGCPLWDALESEQEDVASSLVAHGADPDCWSPGPDGCQQTLLHKAIDENREDVAQFLVRSGCDLNSPRRPGPNGAGGDEAKDECTPLHLCCQWGLEQVVQTLIEHGANVNARDAEGKTPVHIAIQNQHAQIISLLLCHPNINLSIRDKKGQSPFATALAVRNNKAAQAILDRLPSAAEQFDNKGRNFLHTAIQKNDMESILFLLSIQVDVNSRVQDVTQTPPLHLAAINGNEMLVRSLILAGARVNDTDAHRNTALHAAAKAGHATVVSALLQNSINFDAVNADGDNALHVAVREGHVTVVRTLLTECTLDAEAVNLKGRNPLHELARYGRDNAATICELFFECMAQYPLNNADLDGNTPLLIAYMKGNGNLCRTLVKSGACLGSMNKDGITIFNYQVATKQLLYRLLESLTQEAPWADKDLCLECGTKFSLTMRKHHCRHCGRILCSKCSGQDVPILKFGLNKPVRVCAVCFDVLQIGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F520</accession>
    <name>A0A232F520_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000923">
        <property type="protein sequence ID" value="OXU25881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F520"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="161" mass="17444" checksum="BE92E9E2203DAFD2" modified="2017-10-25" version="1">MGSKLKVAAGSCHPRLRRVSKEAVANNAHAHALQKPRHHPFRSRMKNGNNSRSSSHCSKCSIGPALVHYPATAPDAVPHFDGHRAVKRPLVARITNKSLPNSERRSINHSVNRKTSFLSNLKPKGGGRKKSRYSVGAAHLPDLPQRESSAAMVDDLEGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F599</accession>
    <name>A0A232F599_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAST kinase-like protein subdomain 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000908">
        <property type="protein sequence ID" value="OXU25971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F599"/>
    <dbReference type="STRING" id="543379.A0A232F599"/>
    <dbReference type="OrthoDB" id="443524at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAST kinase-like protein subdomain 2" evidence="1">
        <location>
            <begin position="464"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="626" mass="72169" checksum="DA4FB978F514244C" modified="2017-10-25" version="1">MLAKRLFRLSTSLRRSSILTQQVLAYHVTPIEKIKDNRSSLPFENANVDELMSELKSRFPSKVLVTLEANKNIIKGPHIIVALQSLVKSYKREISNKSIKTTDPSNHHAFLKPIYAIIDSRIDQLTNSEAIEILSLFAKIKIPISVDTVQLILKHICNNLNDMSLIDFGTLSLIIRRMPQSPLIKGVQKALEKKFVVKLSIDFDENNITFLESALSFISYHVNGKNYELLEHVIQSLENYKDDISLKSSILILESLCNMRYHPKGWLDILHRVEDVILNNIKELNVNQVNFIIYILSERLKSADILLAKEFYNPDFIDTLIQKLISDDVGLNSALSAIKCLCFIRHESKELLNYTFATYFEKTILSGETFDDHINKLLVLISGASAMMHKNIFWKEIEDFIMKSDSILKYSHETLTICALNLLCLESYHHSMLRTIFDCNYDYSKEQFLHWTFCKIYQKLKVEQNYDGPVASESQINALKRLSFETYKKKGKKREDLVDYLRDGLGGSDYVKSDFTTKLFHLIDHVVILDKNGNPVPISTETNKSETDTLNYLENLKVPPASKVIVIILMPHYWFFRNSGNLMGNFKIVVNTLEAMSYKVVAIDESMWYTIPKEQKTSFLMKEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F626</accession>
    <name>A0A232F626_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcriptional regulator ATRX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011084</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000922">
        <property type="protein sequence ID" value="OXU25889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F626"/>
    <dbReference type="OrthoDB" id="9900844at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1232"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1617"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="665"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="818"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="913"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1544"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2044"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="706"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="951"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1096"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1143"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1544"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2065" mass="235907" checksum="FC4D81AB20F68B0A" modified="2017-10-25" version="1">MATKNRRTKGKDWSESSSDDVSDDDDAAEVLKMRRISYVQREKLRKQRKTQKVLSKLCDDDEEENSSDMELKKQRSSRLILPSLPIGFTKKKSRKDHSSPLSVSSDSSSKEKKSKVSKTNTSSKNKKRDSIKKRTIQSSKPKSPFNVDEKIVNKKSVKDKSQSDSDSSKEFQKTKNKKPSKTRLSLGQCMMEDYSHITTPSKSDDESIRVETKEEISLKHYTIEEIDKIQKIVDEFKEDLQRISDYLLKKKINVLRDAKFFAHKILSVYDVTHEKVKESRGSFADKYRSWLHNFGSKKSVASPIKSVKNYKLSSDEVSDCDSDKIFSGDETRSSKKDKSALKMQDMEKSKVAEVIVTGEESVHETNEEEDPLMETTGKQNRSSRSNSTSSIDLFESTASEVANTPVKSPILSTSHRSLRKTLLLANKAKNVSIPMDIYEAPVEENEKMDIFDTTDKANTVDSKTKELTKSKVHKKEPKDVEKTTVHEDKPNDHECETKDHEGEPKDHEIGSKDHEIGSKDHEDVTKDNEDESMDHENKSKDHEDESKDHEDESKDREDESKDHEDKSKDNQDEFKESEKLAEEQRMDLSEISISQLPTPPATVRDLENEAREKLLADCSDSDSSVFSNTEQNVGNNAETDADSEISVNSTCSTVIGGTIDLLKKKKQLVKKKSQEDKKKNSRKDADSTNNSLNQTNRLPLMKTKSKSISSDSLSSASSSDSATEEKQEVKKCHNSASRGDDNSSDDETDLLASPLSKRRKLAFIQQKNQHYKIDKKLRIQCRVVLERLSNSVLKKHAKALDRSKKYVANKKLKSMTNLDSLEGSKKRSSKKILGDVESPQLSESSNGKEKKKKSGKDEKKSLNDHLGYVKNEIGSDEDIAADELNDTGSNEDMVLIDDVALVEDDIVMEVENQAKEALLNSDSNSSDDKESDDKVEEKDSKKSKKVKGKKSSKDKPVELSEDKSENGKSENESNKSDDGEEKTNKAAWKDDEVLNFKVTDTESEEEKFNKSQEKKKEKNMNDDENNDEVSILEVSPIKAPVKKSQRKKRRILDSDSDSKFNSSDADSDEEIESDEEKEEQEEKEEKKKKGRKRRQKSSDSDTSSDKKPKSKRKRIKKVTTDSDSEDQDSPNKGRKNIRKVLKDKHVADDTKKAAQDEEERLKRIAERQKLFNEMYDARLAGEAKVDKLVLDFDEETKQELVVVHEELVKRLKPHQAKGIKFMWDACFESLKQIEKSEGSGCIIAHCMGLGKTFQVVTLAHTLLTHEETGVRTVMVVCPLSTVLNWVNEFKTWLKHVKDGDEIEIYELTKMKKNIERKYQLESWQKTGGVLIIGYEMFRNLTSTGKKMRKAMQESIMRSLVDPGADLVVCDEGHLLKNEESALNHCMVQFVKPNLLGTKKEFLNRFVNPITNGQFDDSTPYDVKLMKKRAHVLHKMLEGSVQRFDYSVLTPFLPPKQEYVIFVRLTDVQIKMYQHYLDNFARRYGQRNGSLFADFQELQRIWTHPYVLRLNAEKVEKANEKKRLEASDSEGSLKDFIDDGSDTEASSISLASSDSNSDIECLDSDKEKPAVKATRSTRLNPKEEPVEEVPIQASVEEAAWWSKFVEEKHFEDLRISTKLSLLFGILKESEQIGDKVLVFSQSLYSLTLIEHFLNLIDNQTQDGGEAENLDNHNGTWALGLDYFRLDGSTSAENRSAWCKIFNNPKNTRARLFLISTRAGGLGINLTAANRVIIFDASWNPSHDVQSIFRIYRFGQKKPCYVYRFLAAGTMEEKIYNRQVTKLSLACRVVDEQQIERHYSNNDLAELYQFDSYEGKSVTLNLPKDRLLAEIFLKYKDAVYNYHEHDSLLENKEEEELDEEERKQAWLEYEEEKQGKRQMMNVGNNMGFNPLLMNLNSFPELESIKLLIQKDYPNLPPEHLDTVARQAVFDMYRFVDQQAVGQIFNNPFVAAQNIPQQNMMAAPPMNIQQQTIHQQNQLMNLINTPQMNYPGVNQMPVYSGRGRPPKHLSMNNPMANMARQMQMPMQPQQNQMPVTRNNDEVEILNNDQQVTQPNIDPASNSNNIQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6A7</accession>
    <name>A0A232F6A7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000811">
        <property type="protein sequence ID" value="OXU26374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6A7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="241" mass="27032" checksum="645DCB91112C9381" modified="2017-10-25" version="1" fragment="single">MAAPQRANSESSSVLNTLINQVPFEMPVPRYQFLGFCTHLEERLTLSETDRNSLDRAYFEHDIAYLYTNNSSNSGDNGADHRLAECAFSRMLSESSGSEERSVALLTVLCMSGKITANKADYKTYKEKVVEVSQRRQSTIGHTIDHATMIAVKLIADDLLNNYALYTRQILRDARSVANVMITMNRPRHRNLVAIGLGIVDLMLSFAVGPDYALSDLQRAQALVSSGRYHRYDGMMLIVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6C7</accession>
    <name>A0A232F6C7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000809">
        <property type="protein sequence ID" value="OXU26394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6C7"/>
    <dbReference type="OrthoDB" id="7698305at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="191" mass="22128" checksum="EC59D9524A633B4D" modified="2017-10-25" version="1">MAKKETENDKLGSNSNDLKEPLLPVSDETEKKDQNFRVPIINSTYKLMQRRIKKHKKNKLLCPEPCTEDSRKRSKVKKRTKKLADVEIASDKNIATLLRSERLLEFIKKGRKIPYEIGRNISQKTGFKSVSDLNNYISAHRKKFIVLVDRKEKHCQSDSQKCNGTFRRTDSVDLDLYFTHHFGDSAENSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6N0</accession>
    <name>A0A232F6N0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000785">
        <property type="protein sequence ID" value="OXU26526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6N0"/>
    <dbReference type="STRING" id="543379.A0A232F6N0"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039932">
        <property type="entry name" value="Spink4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179:SF0">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179">
        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012421013" description="Kazal-like domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="132" mass="14359" checksum="BCD65ACC5D2B2C42" modified="2017-10-25" version="1">MMRCVLLVILAVGFCHAQRDVFSDQDGFVFPGEADRPSKFPLNPTNRPTNPTRPFTTSSQRTTQTPTGNPVTPNMNDYNQCINNCRTTSEYNPVCGTDNVVYSNPGRLSCAVACGNNIAIKGYGQCSGTMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6Q7</accession>
    <name>A0A232F6Q7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000890">
        <property type="protein sequence ID" value="OXU26047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6Q7"/>
    <dbReference type="OrthoDB" id="7666864at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="232" mass="27326" checksum="13ECE634859956B8" modified="2017-10-25" version="1" fragment="single">MDDYRLYKYYRSTGFGWKSLVYNYLLTDRYFRTLFHFGPRCGAITAITSFLVLLVLTYTITVSILHKLVLINTFSPYKTSIDERERPYRIRALQQRYTRQVHLSAARARKEPRKKERTADTHIFNSPVRSKEKTGSNLALINPRHTWRGRAAGALKSRLNALNIGWLIYDGFTHKSWTIFLLNTKKFNELRHEAEKKLPRKESVLQVRPAYNCINKHLQQADVFLDKTKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7H6</accession>
    <name>A0A232F7H6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquinol-cytochrome c reductase complex 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_005047</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000718">
        <property type="protein sequence ID" value="OXU26816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7H6"/>
    <dbReference type="STRING" id="543379.A0A232F7H6"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="14474" checksum="70774B39ADA48EB8" modified="2017-10-25" version="1">MMRASLQFIRRVGTKPEDQTKIIGPTLQQWMYNKAGFNQYGLMRDDMIHETPVVKEALRRLPEDVLDARNFRIVRAGYLCLRKDVLPKEQWTKLEEDVMYLQPYIKEVEAEIAEKKEWEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Q6</accession>
    <name>A0A232F7Q6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_000727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000823">
        <property type="protein sequence ID" value="OXU26327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Q6"/>
    <dbReference type="STRING" id="543379.A0A232F7Q6"/>
    <dbReference type="OrthoDB" id="5589010at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000006">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="955"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="955"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="754"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="829"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="893"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="830"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1066" mass="121546" checksum="8F58D2075280FF2B" modified="2017-10-25" version="1">MDIRGVEITNQLRSAIRAKLLELGVRYDDELPDYILVMVVNKKSRSQMNEDLNLFLEDNTETFVNWLHDQVLKKLQKVTVAKKKTNKDTESTAIVKQEEEEDKKKPKIEDEPPMKSDTPTGEPTKIERDKEFDDLVGDLAILNEDDGKSNLKEPQVDDEEKLQNTKIDMLDSGDSSDDSRLEYPERKSLHSSVSIPKSSSIDKTASIEAEKVNDTSNSILKRMSNDNSSEEPAPTAKRSKFSNDSDSEDDSSVKSISKPKLLSVVTVKTKPSEEVSSLGSKEETQTKSKSDAKNETSSQRSSLNQSKSIDRRKPRTEDLRNESRRDNRHPIHNSNSEKSSRIEETRDKERLGSRSGTMKSRLGTNSNKKDVLSLKSTNSTKISKPRISNVKSRLGVRSKQQDRELLRTPSKLSKISQKHFEDEDDDAECVITTSLKSHIIAVQKAKKRKQTTSDALIKPKKIIQEEIIEEDEDQDDKVPSKVIVTPRPLQPLKPVQKRATQSLLLKAVAEANQSVVMQKKVDPCLKEQTKPNNKIKITRDPWEGKILSVSLNGKRRNVMEKIQVELNNPDKSKSKKSLSSKKSQVVTDDHMDVVKSLFKRSDNKQKFLVTLNGYNNNVLKEKNSDEEERVNVEVLEVEDDDDELSLINNPYDAYEDEVQIIENDDYSNDHPLGRDQEMRQEPSAAYTNTYKDTYADTHKDKYADKYKDKQVKEYADKPAEQYTDKQANRHADTYKDKYADKYKEKQIDQYADKYTDKPAVQYPDKPAAQYSDKPAAQYTDKPAAQFSEKPAAQYSDEPDNQYSNIPVLEYFDRPDNHYYGIPAAQYSDRPVTQYSDTPVNQYSDRPANQYTDKYSDNPAAQYTDKYTNRTAAHYTNKPVVQYAEPKLTRNRIDNRDHLRVEQISGRNHRRPSPIVYSRSRSDSPANKPTVASTVTSVLRIKKRPLISSIITTVADKSNEKCRYWPTCTLGKKCAYLHPEVLCSSFPACKFGEKCAYMHPKCKFGSACTKLGCKFSHPPVKCKYHPYCMKPGCPFSHPKTSSSSKLAQGLTPNMTTVRAKFTWKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F830</accession>
    <name>A0A232F830_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000772">
        <property type="protein sequence ID" value="OXU26603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F830"/>
    <dbReference type="STRING" id="543379.A0A232F830"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000022">
        <property type="entry name" value="Bumetanide-sensitive na-k-cl cotransport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF48">
        <property type="entry name" value="GH09711P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="114"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="7">
        <location>
            <begin position="618"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="114666" checksum="EC9DA62DD4079D30" modified="2017-10-25" version="1" fragment="single">EKCLAYRIGMEGRFQSKGAEADGNNGEQITMNSKRPTMTLNVNGLWDVVPRLDHYRLSRRAKRPSLAELHEGNPAKDLMNAATLEAGLPMAGLNASGQPAAKKHVGIKLGWIQGVLIPCLLNIWGVMLFLRLSWVVAQAGILHTCIIIGISAFVCVITTLSLSAISTNGEVKGGGIYFIISRSLGPEFGASVGIVFAFANAVAASMNTIGFCDSLNQLLHEHGLKIIDNGFHDVQIVGIVAILVMVLICAIGMEWESKAQNFLIAIIVGAIADFLIGALIGPRSLQDRAGGFTGFNSTVFMDNWLPDYRYSEGANQTFFSVFAIFFPSVTGIQAGANISGDLKDPASSIPVGTLLALLISMISYVTFVFFAGGAAIRDASGKIVNGTIAMCDPFSKDGCKSGLHNSYSMMQLMSIWGPFIYAGCFAATLSTALTNLISVPRLIQALGQDRIYPGLIYFSKGYGKSGEPYRGYVLTFFVAALFVLIANLNAVAPLISNFYLASYALINFCTFHAALVRPLGWRPTFKYYNTWLSLLGFIACVAIMFLIDWVTSLVTFVIIFALYLIVVYRKPDVNWGSSTQAQTYKTALSIAYRLNSIDEHVKNYCPQILALSGAPNARPALLHLANLITKNNSLLICGEIYPSRMSYRVRSAHLRQGYAWLQRHRIKSFYHVVEELSLEKGASAMMQTSGVGKLAPNVVLMGYKTHWSSCSYKELQEYFNVLHNAFDHRLAVAILRIAEGLDCSSVGSSGSAEDEQHSGALVQSSYDLAGNTLMHADSDLSMSGRGIARVQSVPSIGTQFIPPDATAPIRDSPTHWNARDHLKNKKRHLAEKMLMNNKQNGLSVVPEYLTIFQKKHKNGIIDVWWLYDDGGLTILLPYIISTRTNWEHCKMRIFALANHKQDIGAQEKEMAEIMAKFRIKYTSLKMVDDISVQPKQETQDFFDKVISEFRKNDASDNAECVVTDAELQSLRDKTFRQLRLRELLLENSSQSTMVVMSLPMPRKGALSAPLYMAWLEALTRDMPPTLLIRGNHSSVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F847</accession>
    <name>A0A232F847_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000730">
        <property type="protein sequence ID" value="OXU26772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F847"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="189" mass="20451" checksum="85E7DDDBA169F6E8" modified="2017-10-25" version="1">MSETRPDKRALHSSSSSSSSSSVLPDTRSVLLCSIVSSSSSSTTDSVAVDEPTKEEQKEEVVRRCGRCIRDFCIIITIIILVNSLVIVFLSAVIACTSDGTGSTYDISTPNTKYSVLLIYVLITEKNSLCVTDRESSPGGRKEKEISYTQSSVLRCGIPALGKRIITHDFCLTVLTKSANAGLFGTKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F888</accession>
    <name>A0A232F888_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000706">
        <property type="protein sequence ID" value="OXU26875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F888"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="46" mass="5069" checksum="5FE9671B78D1EDB4" modified="2017-10-25" version="1" fragment="single">EPPEKERDGRINGGSSIGATLKRGLSLPLFARWRLSSIRSSNCELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8T1</accession>
    <name>A0A232F8T1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000703">
        <property type="protein sequence ID" value="OXU26900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8T1"/>
    <dbReference type="STRING" id="543379.A0A232F8T1"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000106">
        <property type="entry name" value="Putative heat shock protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF519">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="382" mass="43135" checksum="AC4CA314C655BAAA" modified="2017-10-25" version="1">MGNEDESVCDCDEPQAGIDYYGALGLNRDCTGEDVRRAFRRLSLRFHPERNKEAAQDKLQDELRRKAFAVVAEAYDVLSDPLKRAVYEQYGEEGLKRGIRGPEGPVKPYVFHGEPMRTYREFFGTENPYADLLDNASNPLPLEDCPEARGEKKKDEPIVMPLPLSLTEVFYGGVKKMKIQRLVLVGDDDDDKEETNKRRRTALEEKILSIPIMPGMPSGTKIVFPEEGDQGPTKIPADVVFVTEDKPHETFIRDGSNLRMTVDVFLNEALTGTIVTLNTVDDRTLRIPITSIISPDYEKTISGEGLPLVEDPEQRGDLIIDFNVEFPSYLSEASKRYVQKAFDVALDDRRDDNAGKKKGSRRIVLADKLYTRSDKLAQICRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8Y4</accession>
    <name>A0A232F8Y4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_009886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000727">
        <property type="protein sequence ID" value="OXU26777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8Y4"/>
    <dbReference type="STRING" id="543379.A0A232F8Y4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="614" mass="69773" checksum="FC473D9A5772C81F" modified="2017-10-25" version="1">MADIESERLHDLIKNIEDIPGIKNCSKYKMYRRQWLTTINFILVVMLIGMAHGHSAILLQQFQNTTMNATKNLRFEDGEMFKKPIIIVNSIDLQSWIASSMVLFMCPGCWILAVFSKKIGRKLILLFAVSLFLISWLIITLAHNAYHVIIGRSLSGLCMGILAGLTSVYQGEISITKLRSTLNAVLAVSFSIGIELCHAVGTWFHWRTTAFFCCCITILTLFMNCRMPESPIWLLNKNKFPEAIHSWVFLRGIRDLDELKSMHVTKSNKMLENAYSEKKEKKYYSTGFLKPLGILLGLFTVTQMSGMGAVTFYCIQMVTDISGPDHAYIPTLILDTFRLIAAILLTIISSLSSTRTLTLCSSFSCSIFLICLSMCILFKLWNPWLALTFLFAFEAAVVMGLGPLPWTFCSEIFSVPHKEVGIVLKPWGSFLVYGCFTLISSIGLYFILPDTKNKSLKEIEMIKTNKRKFGIFLDLTANVDGILNVDQAELQGRLLRSASMKKKESRRESEVRVEVTLEDGHTHGKGNYRGELLVEYQCLETRYPEQSKRLKFLWVKEPKKALEAKFVGAIRSHNKIITPLIATASSRNYSKFRNIENNCNFFNQNEYLSIQHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F945</accession>
    <name>A0A232F945_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_015085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000621">
        <property type="protein sequence ID" value="OXU27346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F945"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF45">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8887" checksum="E3849C2A8434EF14" modified="2017-10-25" version="1">MYNNRLYDCVDFCGGVRCMKLVQHPNVVRLYEVIDTHTKLYLILELGDGGDLYDYIMRYEGGLTEEVSYIYLFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9T4</accession>
    <name>A0A232F9T4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000647">
        <property type="protein sequence ID" value="OXU27199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9T4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556724" evidence="2">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="254" mass="27210" checksum="45A6A3D1543AE450" modified="2017-10-25" version="1">MSVWMYLALHSAISPFFGLFTIPVSFEDIKEVPTPGRASDHPDERKEASKSATIIRKTGAASNIGVGEPKPPAAIRSVRSPGGDDGSTDERPPEASREESDCLEINTNAVASVNANLRSAQGTVAGLNGKICQNALEISSLKAEIKKLQASSSQPSTSSTSGHSESVVVKWSTSNGLRLNFSKCFIILFSRRRILLLFDYSMGDSPLQRTSLIRDLGRKATPTAIIGSTPPCVGLRDTGILFLKKFAALGLSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB94</accession>
    <name>A0A232FB94_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_015372</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01000478">
        <property type="protein sequence ID" value="OXU28104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FB94"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="530"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="837"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1307"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU28104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1523" mass="173054" checksum="D4899824D34B7D2E" modified="2017-10-25" version="1">MQRSKRQKTDKSGRLAALEKLKQLKGKGVKHKYEVDDLENVYDEVDEKEYGKTVLDRQYDDWIVDDGGGSGYVEDGREIFDDDLDDESVREAAKQSHLKGPRKRKREPEGKKGSITNMFSNMANKKKVEEKIEDDDILGDLMSELKNDSDTPKRKETPRGNKFLSTPKTCTKSDDDKLLDSMIKDTIKKPQPPPKKTVLDDLDNEVLYDIPVTTPSKPKIKSIEVVKTPKIVKETKALEPQKPSVDTENLNFDDDFVADDFPTMQNSIKESSSNNRSFNGSSTASSTQAAHKNGNVEDLNEYIGDISDIDFGNTEMDNDVANQSFTTLLSTQSTTVLTQGLDKSQMWREKDADLHNDAVFAKIWEEDFIPSSVATPSKTPIPATQLPLPTTTNAAGEKVFRFFWLDAFEDPYKQPGVVYLFGKVFVNELNEYVSCCLGVKNIPRRIYCLLRDNPNGSDGNEEKSQGQRGWEELKEYTAKLKIKEFKCRELSMKYAFEREDTPTQAQYLEVRYAATDPPFEADYSGPNIEAVFGTTVNALELLLIERNLKGPCWLDLKAPLPVDNAFSWCKVQANCTRMENISVCTEQPSGVSIPPIVMATINVQAAYDVKQQKNEIVNIGILLHHKFQLDKAPPKPPFDQHYCIVTHPRSTGWPMKARDRLDKIRQTKVIRCDTELELLEKFLEILQRSDPDIFVGYDCGFQFEVLMSKIFQLKVKNWSSVGKLRRLNPPYFKGKMNLGSIFCGRPICDITNSAKELNLKVRSYDLASLCVAVLNKKEYECKEVKSEEIASKYYANAEQVEKLIQSTMVEASYILGIVTELNILPLALQITNIAGNTLSRTLSAGRAERNEFLLLHAFYQKGYITPDKRTQTKKKEGAEATHGGKKKPAYAGGLVLEPKKGFYDKLILLMDFNSLYPSIIQEFNLCFTTVPGAAFANVDDLELPEPTVEDGVVPTEIRKLVQSRVEVKKLMKAPNLSPELKVQYNIRQLALKLTANSMYGCLGATHCRFYAKGLAALVTMKGREILQNSKALVEKANYEVIYGDTDSIMINANILEYDQVFSIGKEIKKDVNKAYKKVELDIDGVFRYLLLLQKKKYAAVTMSKLPSGQMQYTKELKGLDIVRRDWCGLACDIGNQILDQLLSDQSSESRVGKIFDILQQVSNNLREGNLPLSLLVITKQLSKNPHEYPNDKKLSHVLVALRLNESGGRKWKAGDTVPYIICEDGTDKMPLERAYHIEEFKKNDNLKIDVNYYLLQQIHPVVLRICEPIEGIDDVLLAQHLGVGDLYKPKKVHTAQEEGEVPLCIQDNRYDNCHPLKFKCRNENCKFEIEIKMTITEFGGVPRPTLALCPNPACDMPPWRYADAIQNRLQQEIRKFISQYYYGEVECENPICLKVMRRITMGTLGTFPKCYNCLDGNVHRIYKETELYNQLSYYLHLFTLNQTHFKNLKPAPTRELIAVYDTLKEFVEKQIQANAYSVVDLTKLFWPNLQESDIDALSKVEDTVPKIEVEDLIQEEGEEDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBD4</accession>
    <name>A0A232FBD4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000472">
        <property type="protein sequence ID" value="OXU28141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FBD4"/>
    <dbReference type="OrthoDB" id="2386367at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1674"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1679"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1851" mass="210861" checksum="0FAF53107E916A95" modified="2017-10-25" version="1">MENLEVTSRDLSICYMNEDLIDEIFNALKKGKKAIRHSISKDVVLVLGNVGSRNSIFTQFITNNRNLKSKKVEDGSFTIVNENDKAHSKPPIGFPILSLEPKSNTAIYDFPEFNKTENIAQDISRTYFMKKIIDFADSVKIIFTTPFSSVTKAVDKQDLALLIEYASTLLNKIEKFEDSIALVATDVEADENEKIVENIAEVLQDFKNEYSTANENLEFSKKAIKFINILLEKKDDKYIHVGIFNRPQDGKAINKNEKLQTNKRSLVKLVTKDIKYSQPNGNDLKLTFYTQSESSLQCFLERIHNNIALAMENINKDVKKHYQHQEKIINDIEFLRQKYFDGYDKLSNTKVALSKMTNTQDFIERLIQYTKDLLIRFSNSNLQSIGNNVDYLNFVEMMQNRSIKPESEKWANKLNTALDFLKKSEKWYDFLIKLNDILSKYDVQKNIDKPNTSVTKFLSQINARELKKQSIINNLKKLLNTVSTENLEAYYEDIKGVKLDEFKIRFLVEILSSTLLQTVQTLCTNDQMAIQGHIVKFADVERWTTESNCTNAKIIKIFALNKVFIDSDFNKTGAQVQLTVMAPTWDVINQRTLVLDGAPGEVGLLSKAQDGQNSVNRLERNGKHGNPGNPGGSSGRFIGIAKTFVNGENLSIYVNGGKGGPGQNGGNGYKGIDGTEGHYPNDRERWICGLGEVTRYCDYPGKKCTKGGDGGDGGAGGVGGYAQKVILIPLDNRSGLHVYNHPGENGLVGKGGVGGSPGEPGKSYRIYASGNPGIHLLVSQWSKNVQIMRNTVSEFVKKCASGKFGADGKNNEDIKLPLVNVMEAPTNIVDDYKNYVREHFPSIRENFLRQFIDQLEGNNATEDLYDAFAYVQELQDLEERFYVSSNRIAFLPFYQSLLSRIEHYGNKILHGNKTDDRKALFYVSTAIKSKVYNLKNNYADSLIIDVSEYLQTVESEFEALTKSEEDASAHKNSADYQNTIENRIIETQSFIETSIMTKIESSLSQIDSLINSLINETISREDDVIKAKKKIEDQQQSMQRTLVWKSLLEITKVASVFLNLLGPVGSVAAAFIGTGATIAENVFLKDTENIADMVSVIPEAVSKSVSAIEKIYDNKKKAFEAQLKDLEKVLKNDKDNDFQDIKEKVSEMKDEYNTQIANKSALDPKIMDKIDNLRTEVVDFIEVKKNQWNPYDKHVKNLAIMQNVLKVGGAAIGGIQNIMSEHKKLEKVGDAIQEQEKNLQKLQQFEKDIYKIIVPVCNNVRKFAKDSQSKLQAKSHAGLDISKWEVQSTLKNLKYKFEEYTKGFKVQADFANLMDYLNEAINTMILLYDRIQDYQDKKELGNYIERINSNILTDIQDAKLRAEVDKLKLFIQSNTVLEKCTKVVQAFGRYVYPFADCYLSNLDLFNNYKQENITIVIQNARYTIDHLRKELQKSKAKLPKEQSEIIQNIKYSSDDPEVGPFFVWNYDEHKHEIKKLLAGFEVLLKSDIKKGLNKDAVKFKQISLRFRTPAQSRQKKFNEKISQFYVTMTHLGNSYYKCNDKIHMIPSNDSIPLIFRTNSDFAYENGNVAILKDNTPILSPYTMWRIQLKRINKKYDLSVLTKFIDMPIDIELEGVGQHIEPGNAKLCNDNMDKYYILDETISTTDYIDVFNKNNFRGLSKVDFFNEISKNSRGLQRPRRSLDERKFAEETENSPFSTSGASDGTKFSCLNTIFNLVESSLAAFKYLNPLNQINQWFNKFDGNIVKEDSTVFKNYDAPVAMTLIDTQFVHAEFGKISKSFIEDESPIEDKPLCNDFSFCNNNNLFLAYLLIRRKSGVKYRKNKTVIMKNLDSEFTQNLAYRGYLPQEKSSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBJ9</accession>
    <name>A0A232FBJ9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000495">
        <property type="protein sequence ID" value="OXU28002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBJ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="12583" checksum="741EE2D6D2D039CA" modified="2017-10-25" version="1">MPQAEVLCTTNRILIEVDGLAALSARVSLPQSVQRHPFVKHPRHQPITPAAVEEISNNFQTTLITCISASNEKISSPTNRRAVGLSGSLECRTNSSLALDAEEAATSFVGDRLDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBL0</accession>
    <name>A0A232FBL0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000530">
        <property type="protein sequence ID" value="OXU27848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBL0"/>
    <dbReference type="OrthoDB" id="7549643at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="392" mass="44438" checksum="D315DBBFBF9C6EED" modified="2017-10-25" version="1">MNTQELLKALDPITVKTVGVYAADRIPNLLRNNNHRVRSKDVRRFGSEASRGSGFCNQTCTSRIMNTQELLKALDPLTVKTVGVYAADRIPNLLRNNNHRVRSKDVRMFGSEASRGSGFCNQTCTSRMYLLRNNNHRVRPKEVRRFGSEALSGSGFCNQTCTSRIVSAPSRVHNVLPNMLLSTSYVINKSNSKRVTLSLESYQGSYLPVVKLSTSTTCFKSVKFDASGWKVFKNYFHLINCYFQDEYRFQNEYARSTKNTKSILIKERPVGTSIFPNLLIDEENDDVLHTVSAPHFNDYSAGAAATVTDGENLRHQPPRAKKQKTVYHQPSICACKSLLTECVNKVNKIVAHIKKFIINCIKNDCIDKDPNSILKTYEMSQQYYALYTENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBX9</accession>
    <name>A0A232FBX9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000445">
        <property type="protein sequence ID" value="OXU28334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBX9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="43" mass="5118" checksum="DC3993DE6D3D82B3" modified="2017-10-25" version="1">MITRSIFMFFKFIDHITVLEAYYVGKKCKTPSTYTFLSEAIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCL1</accession>
    <name>A0A232FCL1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000464">
        <property type="protein sequence ID" value="OXU28188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCL1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="127" mass="14505" checksum="3BD6B6C379494100" modified="2017-10-25" version="1" fragment="single">PDIGFVRDKTTSSCRRELTLYSLNAAENSGPLKQRFFPEDYRRDSKHHVPARTPPANRLSGLAVTDRPFSLSALKVTLKIRGNKYAALALIPSSPRLRPEQVYQLIKSPLMASKHLVITFIKRRRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDR4</accession>
    <name>A0A232FDR4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000357">
        <property type="protein sequence ID" value="OXU28934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDR4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013212040" description="Invertebrate defensins family profile domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7485" checksum="3BAEB2B858C1EE9E" modified="2017-10-25" version="1">MKTLAFLLLLMLLAHVASSESAYCRRLDCWHDCILKFYRYGVCVGSECQCAKRRIKHKNRASYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDY9</accession>
    <name>A0A232FDY9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000362">
        <property type="protein sequence ID" value="OXU28885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDY9"/>
    <dbReference type="STRING" id="543379.A0A232FDY9"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="70321" checksum="59828EA52420C649" modified="2017-10-25" version="1">MLDNFRTPICLAKSPEEKDIIKKCSKTTKKIFLSIMSLSQSTGLVLLVIPFLTSETREIPLPFKSYQPYEMSSATNFWITYALQIFAAIYGVLLNVSMDTMVYGFIIMATGQFEINCYRLENSTCSMRDCIEHHVLIQDIVYKIQHFFIYVVVPLFLFSLVTLCTSIFQMSQKQVASFEFLSLTMYLACMLCQVFLYCWFGNELELKSNAVANAIYCSAWTDFTRREKRNISFIMLSAKSAYVSICKTDVFQSETGEMDVLPLNFRTLWLCGIWYEENEKLTVSRIAYRFLVVCLVFYFTFTLSAVVFVENSDVSELTEAIFLAVTYITLCLKIVNFAFRRGEMIKILDDFRHPYCKAEDSEESEILAGYSNQARKMYIYLMAFVMSDVAYFWSTFAFKVSKNIMDLPYHTYQFYNVSSKAILFSTAALQATSVLYSVFINISFDTMTAGLLILTTGQLELNALRLSKLAEHNVDSMNGYIAHNVLINGTVDKIETFIMTVVIPFLFFSLLSICASVFQLSEYSVFSLEFLGLFSFAICILLQVLVYCWFGNELMLKSEAVTDAIYRSDWTMLSPQNRKSLQVMMICNKDGRTVSFGGQCSLTLETFVWVRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE35</accession>
    <name>A0A232FE35_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000347">
        <property type="protein sequence ID" value="OXU29021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE35"/>
    <dbReference type="STRING" id="543379.A0A232FE35"/>
    <dbReference type="OrthoDB" id="3213154at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21980">
        <property type="entry name" value="HMG-box_HMG20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="80"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="80"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU29021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="335" mass="38049" checksum="19E58896C78737F9" modified="2017-10-25" version="1">MSEEKSLNNVSENSTEASHSNLNGGVQDLSNNKSSPVKSEKANDSVQENSALKRATTSSANNSTGKAKKRKRCPRDATAPKQPLTGYFRFLNDRREKVRSENPTMPFSEITRQLAAEWNVLPADIKQQYLDAAEQDKERYNREFNDYKQTDAYKLFLEKQATKKEKKNQKKEKVSNGTDTSTAPPAASENNTSRKEKNEQTGTWDIPIFTEEFLEHNKSCEVELRQLRKNTADYESQNAVLQRHVDSLHTAVNRLETETNYQQTANEALQRHLDMLRSQLASCFANIPLTDCFEGATLQNIDSYVERLDSLVNTNTEPSLRSAVRTAVSRLDFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEH8</accession>
    <name>A0A232FEH8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_012954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000390">
        <property type="protein sequence ID" value="OXU28717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEH8"/>
    <dbReference type="STRING" id="543379.A0A232FEH8"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="65"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU28717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="187" mass="21063" checksum="6246E88D98AD10FD" modified="2017-10-25" version="1">MDPSEVEFLGEKQLVSIVPNFSFGVIHLISGSIGPFRAGLPVRVPIWVALSLKQQQKCRIVAQEWMDMEKLTEILEEEKQSKLFTRMPNNHFMDEAQMLLTAAPDDIPDVDNIRTIIKDIWDLRMAKLRSSVIGFVKNEGTYAKLDHLTAMEINSIRSLLPDALDIMLHMEQAGKSAASQSLDATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF05</accession>
    <name>A0A232FF05_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000337">
        <property type="protein sequence ID" value="OXU29100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF05"/>
    <dbReference type="STRING" id="543379.A0A232FF05"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="615"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="927" mass="104897" checksum="60FF2004D5BFC220" modified="2017-10-25" version="1">MASGREECFWRAKLRVMNERFKSRLDENVFEGVREPEIHHGLRAAASTLLHGVFTDMCFCDETQEYLLLNRGVEIQRYSMQGKLLRPSFSLEPTQTFSRVQWFPASRPSSQGCLVCHEPEAENIWILERSGDELQCLKNEFYTKALYHEPSRNELVVVGSHQTTKYSLDDKEQTERELESSKALTYSDPEFGPTWQLDCSALIPQTACLSDSKFKALYAKYYYARNMTVPARLVASYLTTLYLMPLEVDADSLSEGPVEFLGKRSNASKAPISAIHFHASTSWIILGDQLGNVVAWNLKFECVMSHTGAHSSKLTLIVSHPSICGFLSCGLLGDKLQVWSCNFRDKIESFDQLGGVKAITVNEEAATVVTLGTRLDYLTMRQSDTISVCSSKVRSLTSTSCPMYPTRVIAASEDNSVRMFSSCGKQLNLQILPEDDLHVVAAVLSGDRKQLFTIILKTGEILVSDASVCPMKFKKVFVNDAAKVTCITVYEHFDEIRDSDGHPKRTDEGNLIVLNPDTGKPEYAHTASVVQLKSSVYSKRVISLGSERCVKVWRIFADLAKPLALYYVLHFVVPIIHVSFMGKILCMANSSENSQVHQVLMENTADRIRLEHHSSKDHTAKIMDMITSETLGLCATSSRDNTVRIWDEENCLTKILVINTCALHITFSSVIGDIVFNLPPKYRAKVVANDLLEEKDEDAILEDSEYKVYDDIVDRNSMLRPVSSIPLASIDITNADNPRVDLLIQKQICALYQERDEDIKRIKDRLIAPTKIVEDRALMTKETWDKYVNDLLSSMTRPPAETPDYDFQNIQKSKSAQVKTYNERGVFQMLFGYSVDEIDDTENLAELIRDSKLPLNGFLPNSILYKTKELVEPLIESVESLVKEPVKYRYPAEFYMDEDEELTEARESIRLSQLMAVDDLKNEKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHV2</accession>
    <name>A0A232FHV2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_011876</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the syntrophin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000204">
        <property type="protein sequence ID" value="OXU30039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHV2"/>
    <dbReference type="STRING" id="543379.A0A232FHV2"/>
    <dbReference type="OrthoDB" id="409749at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06801">
        <property type="entry name" value="PDZ_syntrophin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000052">
        <property type="entry name" value="Syntrophin beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF12">
        <property type="entry name" value="IP02644P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU30039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="239" mass="24787" checksum="73D99B1C21F3519F" modified="2017-10-25" version="1">MVELSSSSGAGSQQPQQPAAQVPLSMLMGLASGSSSSSSSAATGASSGISSRAGILETQVRGQWYRVFVSLEDDYLSISLDESCDSSSGSSTASAVTTTGNGLNNGNNLNNNNIDSLGDPDVPDSVANQKRTVRVVKSDNNGLGISIKGGKENKMPILISKIFKGMAADATEQLYVGDAILAVNGEDLREATHDEAVKALKRAGKIVELEGQSLRFFFSRTARDACSDESTLALSISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIE3</accession>
    <name>A0A232FIE3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serendipity locus protein alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000153">
        <property type="protein sequence ID" value="OXU30524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIE3"/>
    <dbReference type="OrthoDB" id="6342160at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007349">
        <property type="term" value="P:cellularization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.810">
        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008837">
        <property type="entry name" value="Serendipity_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF33">
        <property type="entry name" value="RE47911P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05482">
        <property type="entry name" value="Serendipity_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="89084" checksum="3480C3A9523861C1" modified="2017-10-25" version="1">MTLKTKQMLRIFNPIDELIKKLEELLNDNEANSVEKVCLKKLICDQLNALAQKFDAASNDNVDSYREMKKKVTAIIEEFCIMDFKQKDNQLEGQIDKQIFGSVTEKFLSLLENLEKSETFSIKQSLQDCLLYVKEMGSACEIEDLQNIKELGASIAEIFKPLQIYKRNLTSNLLADKLALFCCQLCTSFGILVLVIKEQHQLNVPIYTCKKYICERLCLCFESIIGILDAPNPSEEDEHFELENNFVYRIDLVLDIISDLSSKAQSEQVNDCADLWFGIEDVFAHAMSIAQICQPYSFKAISGSCQTILTEYENLKKQLQSDPPDPTMNNLFMNTLTDSLYRLERKINISVLTLVMEVFSDPFGALKRLIKICGTSLHVSERTTNDLDSAIEEFDQLSDKAVLIGKFAIACCRDKNRAARIKNCLASFESLEMELIPAVSAFYLHPNNKEMRACVKLLTEQWQFEMNRFHHTVNLIIDPAAYCQIVLDDLQERINEMSNSLDNRQDITQLQVQHVVQRALSLSKQINATLEDVGQENIDKQAIMTIREFKAGIYEADAASKKFLINKATAPEQLRVIHRCEIMLKVIKRLLPVLSNIVNNSVTMGTVNTAHDSKSKAKKSLICTSAVGLSSQSSFQELSIVKKSSNYIRTPYSVKSCKKPLSIQPANTVLRNESDVSILIPYIEKGRMMRAEWSVMYKTPQTCKSEKPIQNMLKIRNLSSVRQHLFSRDSFLDETEIDLTSESLDLTNILENITGLSETLTSVASNKSTFDNSKSTSSSSEQVIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIR9</accession>
    <name>A0A232FIR9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_007298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000134">
        <property type="protein sequence ID" value="OXU30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIR9"/>
    <dbReference type="STRING" id="543379.A0A232FIR9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940767" description="Receptor ligand binding region domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8156" checksum="728994DB54B77DB6" modified="2017-10-25" version="1" fragment="single">MVEFIAVLTLICELLADGVAAIFGPKFAQTRDIVSSIASRFNIPHIEFSFREIGENDTSANSINIYPSSKMYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJS6</accession>
    <name>A0A232FJS6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000100">
        <property type="protein sequence ID" value="OXU30984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJS6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="53" mass="6451" checksum="DC756753157B64FE" modified="2017-10-25" version="1">MFSRLCVKRAAKSCRTTEIEERAKRRRRIYPNSGFYERELEKHQNRDDGYSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJV6</accession>
    <name>A0A232FJV6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_002790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the smoothelin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000103">
        <property type="protein sequence ID" value="OXU30952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJV6"/>
    <dbReference type="STRING" id="543379.A0A232FJV6"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000009">
        <property type="entry name" value="smoothelin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF88">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="44"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17938" checksum="3796EC444A884B6A" modified="2017-10-25" version="1">MSPFAKFRQLDRQNSAPCSPSTPKTPGKEFQFKFTDPTVQNNAALIKERLLSWCRAKTKEYENVQLDNFSTSWSNGLGFCALIHHFRPDAFDYHSLRPEDRRKNFELAFTKADEVAGIAPLLDVEDMVMMRRPDWKCVFTYVQSIYRRFKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJX2</accession>
    <name>A0A232FJX2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000110">
        <property type="protein sequence ID" value="OXU30883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJX2"/>
    <dbReference type="OrthoDB" id="7689747at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="199" mass="23324" checksum="AC335D28678C4D4F" modified="2017-10-25" version="1">MKKSPLSTPGGQGGNFYRGRGRQRGYGHNQMRNNNDDYHRFPGPNNAGNYQFQGNMIPLETSSPTFYHNNRGNRRQPNERNNHRFSNTGISGSYNQGYNNHRNNFQANSGSPYTPQKFQRNKHELDETEEKLRHLRICRKPLSSTINRKVPHEMDDPYWHRKIPISEFVDLESVFEDPWAELMEDLEKKKSSKSYNCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK34</accession>
    <name>A0A232FK34_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000115">
        <property type="protein sequence ID" value="OXU30828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK34"/>
    <dbReference type="STRING" id="543379.A0A232FK34"/>
    <dbReference type="OrthoDB" id="7693469at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="91"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="247" mass="28515" checksum="DBBC7A2B99188EAB" modified="2017-10-25" version="1">MKQTPGPYKKSCEGSKIGYYNVHCILEEKSDTQQKCIMAMSRIAQIETSLKSLKTFSGDINGLPLKTWIENVEDLARIDGWSQYETFYAAKKSLTGAAAEWLQWMQTTGQVKCWLDLKVELKKTFLYEVNEFQVLEKLRTEGPKRGESLLQYMYRMRRLASQASVSDKLTLAYTINGIEAFTFHDLRLNNCQTFAELKAALLTYDEKKLHNILSYKMKNILLTLGALLLFLFYKIMLSFILPKETSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKT0</accession>
    <name>A0A232FKT0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Single-minded</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014929</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000065">
        <property type="protein sequence ID" value="OXU31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKT0"/>
    <dbReference type="STRING" id="543379.A0A232FKT0"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000083">
        <property type="entry name" value="Neuronal PAS domain protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000047">
        <property type="entry name" value="SIM bHLH transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF36">
        <property type="entry name" value="PROTEIN SINGLE-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="209"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="383"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="89067" checksum="749010D5D4F7FBF8" modified="2017-10-25" version="1">MNACNYRTAEMPTTMLNHHQLQNQMLKLERMAAGVKRYRTVDESYVESSWKRRKECSLTDTLDLSPPELQHQQLQQQQPQLQQFRCRGKNTSVPQEFRFNNNNAQQPNNNTNTTIALASGTATPAGSQEVGMKAKSRDAAKNRREKENQEFGELAKLLPLPAAITSQLDKASVIRLTTSYLKLRNLFPDGLGDAWGAAPPLNHPGEASIKELGSHLLQTLDGFVFVVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHQYDHEEMASVLSGSCLPSGSLPQPNAQGDIEIERAFFLRMKCVLAKRNAGLTSAGFKVIHCSGYLKLKHVAVPGGPEYDESGGGGTAPVGGYELHNVGLVAVGHSLPPSANTEIKLHHNMFMFRASLDFKLVFLDANVPQLTGYESQELVDKTLYHYVHVSDTLHLQQAHQILLCKGQVTTRYYRFLTRSGGWVWMQSYATIVHNSRSSRPHCIVSVNYVLSQTEAKDMVLSSEQKASAACPGNPPSTPMPKTPLPSVASNASNAEMPEPKAQTPAQQHNSPTSPYRTRTLTETTADSEFTDSSGYVSSEYVPNHPLAYSMPPTPFAAQGTPAPHEDGGYYFPDLMYQYGGNPHEHLTAVQQQQPQQQHPQLMHHVPSPMATMQHSPQNQQQQRRPYSASSSSCGSTDASDTHLSSPLNANHIIEAPRSVNSFSPYQQHPTHQQTPQQHHLLDQSPPSVASIDASAAMFSNCSFNNLLNGYNNAANPVVPGHHEQAYPGMHENARHHHHHLHVDGGVEHLHDIPLYTNSQQYSPNSVQPHHQFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLJ6</accession>
    <name>A0A232FLJ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin-K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_016116</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000041">
        <property type="protein sequence ID" value="OXU31626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLJ6"/>
    <dbReference type="STRING" id="543379.A0A232FLJ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20530">
        <property type="entry name" value="CYCLIN_CCNK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20531">
        <property type="entry name" value="CYCLIN_CCNK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000018">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000021">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 11" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="142"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU31626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="606" mass="69472" checksum="D1134192DC211A30" modified="2017-10-25" version="1">MPNWYYDKEAFKKTPSIQDGIDYATEYKYRKEGARFIVELGSVLELGYNTWATGVVFFHRFYMFQSFKDFPHYVTACCCLFLAGKVEETPKKCRDIIKVAQTILSEENFKTFGEDPKEEVMTMEKILLQTIKFDFKVHHPYSFLTKYAKTLKGDKNKLQKMVQMAWTFINDSLCTTLSIQWEPEIIAISLMYLAAKLSKFQVVTWKGKEPYQTRWWEMFVEDLNMNVVEDICHQVLDLYSPEEKKRKPTERGPLKESLKSLSCKKPDQQKPVVPSTQISLVPLKKLVSSAQNSDNLSWIFLQNPAISSAQIAMIPAVKKQIANADSRTMAIKTEPILIKNEPVIIKTEPTYEESESSTTESKIKTQPFAFVNAPLYIKTESLTTNTSPASIEVPFYKPLMTIPTSGTPISTPSPVISAGNLQPYSPSFPLPDCSMPPPTYNLPTAASVSAKAQTNGNYINPWKTNVPTNSGNTETDKFRETVSYPDIYNNNSQKDKFQNLMRDHLRNSDNDSQKCSNWDNEDWDNPNGNCKNESSNFDDNFRDKRYSNYFNSSNQTLIDDVGVSMIKQKILTEVFEETRVAFIRIDLPTIVRRETRSQKFLVLRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMB4</accession>
    <name>A0A232FMB4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospholipase A2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000035">
        <property type="protein sequence ID" value="OXU31723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMB4"/>
    <dbReference type="OrthoDB" id="7593692at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013607">
        <property type="entry name" value="Phospholipase_A2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08398">
        <property type="entry name" value="Phospholip_A2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase A2-like" evidence="1">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="14711" checksum="5031B57FC0EEE9C5" modified="2017-10-25" version="1">MIVLEFTQNKKEASPRNYILTSQFLFEHTVRRRGRGLLNTLINKLPVELHLLGYQYCGPGTKLAKRLSCGNPGINGLDRACKEHYIAYLENQEKVQARNATDKILVAKALQRVRVKYYYSSKCHEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-05-29" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMK5</accession>
    <name>A0A232FMK5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000014">
        <property type="protein sequence ID" value="OXU31954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMK5"/>
    <dbReference type="STRING" id="543379.A0A232FMK5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035060">
        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16865">
        <property type="entry name" value="ARID_ARID1A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="1">
        <location>
            <begin position="74"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="364" mass="41069" checksum="8966FFFEC34C99CD" modified="2017-10-25" version="1">MWKSECSVWTPITLIKYNSLDYSKFVNDEILFMRKSFFDAHTSRERYRCCLRNGHSLSALKSDSLSKLYEMDDSMERRSWLDKLVGFMEERRTPITSCPTISKNPLDLFRLYLYVKERGGFMESSKNEYNIFKPCYGGFNAGAINQNPSPAVCGMWPDSISDCVSVIIVQVLVTKNKTWKDIAGLLGIGASSSAAYTLRKHYTKHLLAYECHFDRGGVDPQPIINQVEAGTKKKGAKGTSSVPSPASFNEFHNPRPCSILYPLLELAELNSRADGPQHTVALTRKGDRGILGISMPGALGRGGPPPCMYWGVTARETRFRERWAADKGKNSIKTLTTKNFMEVPYYSPKVPVWVTEWQRPCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNA5</accession>
    <name>A0A232FNA5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_012281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNA5"/>
    <dbReference type="STRING" id="543379.A0A232FNA5"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU32152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="174" mass="20337" checksum="539E4B01E54EAE55" modified="2017-10-25" version="1">MIEGSSTSSSSQQSTQKPWDRPFACPLCGKTYAWKVSLTRHLREECGKLPQHVCAYCGKRFKQRSSYQRHMLTQHQCEARIYGCGRRVSDLKSQKGPYPFVLAGGDYYKRVGRHVCPSCGKEYRWLQSLVRHKREECGKEPQHCCYICGQLIRHKWKLKRHLLEVHRVVYMNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNW5</accession>
    <name>A0A232FNW5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000009">
        <property type="protein sequence ID" value="OXU32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNW5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="11017" checksum="F4556B2BA289F302" modified="2017-10-25" version="1">MEVISPSTPGFDILKELPLEIAHSILLKFDPDDSLLNCALVSYKWLKIRKSSKVLRKRISNHIHRVNRKSTLENSRQMPLLTSFKKSSSYYTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED18</accession>
    <name>A0A232ED18_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01009329">
        <property type="protein sequence ID" value="OXU16239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24885" checksum="3ADC6E0BC1C26924" modified="2017-10-25" version="1">MVRQXWASEMRDLSRAEAKIFTQLITGHGTLGYHQHIIGRVNSPTCRWCNQNEESTLAEKRYRALGMTTCEPTAIQSLTVRKRRCTLXAVHGWLKERHLKEWCDSTGCRQARALIGSCIKEDWASEMRDLSRAEAKIFTQLITGHGTLGYHQHIIGRVNSPTCRWCNQNEESSIHVLCHCLALAEKRYRALGMTTCEPTAIQLLTVRKVIHLYKTLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE04</accession>
    <name>A0A232EE04_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005802">
        <property type="protein sequence ID" value="OXU16552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE04"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="11435" checksum="702FA6EAD75C5A88" modified="2017-10-25" version="1">MAVQFWGQGVEEVPELEVHKSDPKSDDNGYASEVGSAGEADEEMVISYRVISAEDEPSSGGWLPCSREDWDAPKESCLICGQSLGNSAFCLHLSGTEEWIPVPCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEE5</accession>
    <name>A0A232EEE5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005371">
        <property type="protein sequence ID" value="OXU16721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEE5"/>
    <dbReference type="STRING" id="543379.A0A232EEE5"/>
    <dbReference type="OrthoDB" id="7698974at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14396" checksum="8CE796D7D02461B4" modified="2017-10-25" version="1">MLEGRPFTIHTNHRPLVYAATQRADKASSRQAHHFEFILRFDAKFAHTPGKDNLVADALSRTISENVETSAEDEEEDARKTDTATINMPTSLDTATINMPTSLDAATIEEDQKADGQLPNLRSNSSLNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEP0</accession>
    <name>A0A232EEP0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005255">
        <property type="protein sequence ID" value="OXU16821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEP0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10495" checksum="CE63F409ACD932A9" modified="2017-10-25" version="1">MQHPTFEGLRQHSSLVDQHLDALKTLVDFKKFKQFYSRHNIAIEDFVLDKMVDDNNDNFKKQYLKIVLSEILGSGLPFIVKDVLNNVKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEX2</accession>
    <name>A0A232EEX2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005198">
        <property type="protein sequence ID" value="OXU16901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEX2"/>
    <dbReference type="STRING" id="543379.A0A232EEX2"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU16901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="211" mass="23966" checksum="7FBF66A7D8EB64C5" modified="2017-10-25" version="1">MATMECKPNENSSSEMLSKSPAFGSEIMDNIKEQDNVGIPLQTSWTFWLDKAISGTTTEEYKANLKKIYTVSTAQSFWAVFNNIPNAGDMQVRYSYHLMRDERYPLWEEPANQNGGTWRFKCHKIDTANVWKEVVLAAIGEQFSESLAENDEICGITVSIRDRDDLIQIWNTDASLASKASVIAKVHSLVPEVTFLAEFYKRESIGDSRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFM6</accession>
    <name>A0A232EFM6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005003">
        <property type="protein sequence ID" value="OXU17124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFM6"/>
    <dbReference type="STRING" id="543379.A0A232EFM6"/>
    <dbReference type="OrthoDB" id="7698356at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="209" mass="24316" checksum="613F15DA29BF8DF1" modified="2017-10-25" version="1">MPISIIYDKDFMSSAFSRIYGGKIRSYKKTTPLRITLADIAKSEIHKLIQDEDCFRILNCGRFRPLHDLLSRQKDLHDSRLTASLSPDFGSPRRHSEDSNHHPLRLYEFSVMTFGFRNTSQTFQRYINTALRDLDFVFVYVDDILIASLPEEEHQKHLDIVLNSLNEYELQANLEKCSLGDSELVFLGHPEKVKAVQEFPKPQTIKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFU7</accession>
    <name>A0A232EFU7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004950">
        <property type="protein sequence ID" value="OXU17198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFU7"/>
    <dbReference type="STRING" id="543379.A0A232EFU7"/>
    <dbReference type="OrthoDB" id="7693358at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052424">
        <property type="entry name" value="Kielin_Chordin-BMP_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46698:SF4">
        <property type="entry name" value="CROSSVEINLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFC" evidence="6">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="6">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="6">
        <location>
            <begin position="348"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="7">
        <location>
            <begin position="414"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU17198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="73924" checksum="9CD5B7EAB1B489E3" modified="2017-10-25" version="1">MIFKLFIRISRLSSSDINSMQTFVLLSSTSLSFAIGLYVFFSVAQRSSSVTAQLSGSVETCDAEGEPIVSPGIPDIKCFDCTCKSGMVQCVKQNCSKIEGCYVLQELRNDECCRKCKGCMTKGVYHESGTEWTEPNKPCKSLTCIAGVITESSIRCRTPCSNPMPPALGQCCPTCPNCRFKGKTISKETSIMPKHDPCTLCDCTFGKLACAKKACPVLNCPESRIVHSFKDCCPRCQGTGTYVDPPPQGACLLGLKLHQSGTQFTLDDCTHCSCENSTVLCQRESCPILSCRREQQKIWPGQCCPQCIGSGSDNGFNIIETDEAKDKTEEVDDQSSQSSQHHKTEKLNTCAHSNTIYKDGETWNTETCETCTCQLGKIKCLAMTCPAIRCPQNSILAIPEGECCPTCEERENKGVCTVFGGSHVRTFDGKLYAFIGSCKYQLSSDCDGGTFKIRLKNTVVGNDVTIKRVSLRLGKIKVDLEQNKSSKVNDRIVDLPYRKQDKLEVKEFSGNIVVTSEIGIKVLWNYMGFVEVTIPKRYRKTVCGLCGGFDSITDNDLTTREGILVEDPATFAQSWTSGEEICLDTRNYGIRGCNPRKDQRLCSYIKGSAFEKCLNKINVTSYYEACLKDMCECPPNDLQCHCQSFSTYVRDCQRLGIPLPRWRKSVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHI3</accession>
    <name>A0A232EHI3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004517">
        <property type="protein sequence ID" value="OXU17781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHI3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14096" checksum="4B222B9230BA2FBE" modified="2017-10-25" version="1">MITVDSVRARGVNIVDFINEAVRRRKRLPSRSFDQFVRVLPFSGSASDEDDDDDKEEEGYDGEKALDPNNLTFLKYCKGDKKRKRGGSSRAAVDTPVDTSIRTVAPPAKKSSTKRTQAWPYKMAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI86</accession>
    <name>A0A232EI86_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004304">
        <property type="protein sequence ID" value="OXU18080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI86"/>
    <dbReference type="STRING" id="543379.A0A232EI86"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="156" mass="17267" checksum="831EB57C4CCDC8C1" modified="2017-10-25" version="1">MLLSPQSVHQNSPDPQPPQEVTSSDNANLDLKELGLDLDTMDFGQLDCDFGDKMETPQEFMDIGDMPMDMDEPDWLESLMPQSPPSSVTTTTCATTPTLNHHTTSSSSQANNDLYDPLLGNSQDPFDDLFNIEDSDFKMSSDLPLTWDNGQVDFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EII7</accession>
    <name>A0A232EII7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004264">
        <property type="protein sequence ID" value="OXU18128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EII7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="19" mass="2303" checksum="B00A66CEBFEC267E" modified="2017-10-25" version="1">MKLLETTFILPTLGTRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIV8</accession>
    <name>A0A232EIV8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004144">
        <property type="protein sequence ID" value="OXU18307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EIV8"/>
    <dbReference type="OrthoDB" id="7764420at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="330" mass="36879" checksum="27533C0AA52F5573" modified="2017-10-25" version="1" fragment="single">QHYQPPSDYSVLELYSPSLYQQQHHHHHGYFQPPTISYPVESPKLEEESYPRSSLLAPADIKTXXXXXXXXXXWLGQESELRGVIELCGSNNRQRLGPLQETPQTTYGPESPVDLRTSELGQVSPHQYQEYAVDSSLTPPYSAPGCSLTCCQEPTPVGQTYYCYSPQSTSPALKRLPCTEACCYPAPKRLCTEEKQQPKEEEQPIQETPLCLRPADEPVSSTVTTPPAPAAQPNKKNAILFKPYLDNPVSKPSAEETSVAVTNNNNINNNNSQEATNFNERPTAQADLALELSFKLPVSFRPPAPQQIQYLEYPQRSAFVRYPTIGVHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJD5</accession>
    <name>A0A232EJD5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004030">
        <property type="protein sequence ID" value="OXU18473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJD5"/>
    <dbReference type="STRING" id="543379.A0A232EJD5"/>
    <dbReference type="OrthoDB" id="7695642at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="635" mass="71668" checksum="BB1E18EA450347F2" modified="2017-10-25" version="1">MNNEADLKAISKKSGYLTNKDKIEPKGICDILNKAPDILNNQQENAEIRDSNFEYLKFTSLQWDILTTKEKERLALSDYLQDIETVRAITEAYEANCKLVRGKGKYQEPWWNNRLEKLKKTTKALLKKAVKSNDNQKWIAWRSKQKEYRHAVRIAQTESWREYCSSVESGKEAARLNNILARNPEAWLGAVKLPTGNYTESDEETLAHLMESNFPGFMIAGDICEAADDQVETGGKGPRHISGCRELANLIVSPAKLRWAISSLDSYKSLREDGILPILLKEGVDTIIGRLVRLTRASIAAGYTPKCWRTAKVVFIPKMGKGSYNTAKDFRPICLTSFMLKTLERLMDRYIKDYILKDNPLCNEQHSYREGRSTESALHGAVSLIEEQIEGPRHISGCRELANLIVSPAKLRWAISYFDCYKSPGEDGILPILLKEGVDTIIGPLVRLTRASIAAGYTPKCWRTVKVVFIPKAGKGSYNTAKDFRPICLTSVMLKTLEYIKDNPLCIEQHAYREGRSTESALHGAVSLIEEQIEGGGYTVGAFFDAERAFNNTTTNSICKAAKEKGIPDPLIKWIMNMLSNRKLTVTRGSIHRQRLRQQRMSTRAGSIPYFMGYGDRWSIEDADQPGSSSGRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJG1</accession>
    <name>A0A232EJG1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_006714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01004023">
        <property type="protein sequence ID" value="OXU18485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJG1"/>
    <dbReference type="STRING" id="543379.A0A232EJG1"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU18485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="283" mass="30697" checksum="E2ECE5A1FE368A46" modified="2017-10-25" version="1">MAKHKIKVGIIGGSGLSDPDNLIFKYKSEIPQEDARNEFGLPSSALHEGTIAGLDVVLLSRHGPGHKITPTSVNYRANIESLRLAGCTHILASTACGSLSESISRGQLVIPDSFIDRTIHRKATFYDGTSQNYPGVCHVPMEPAFDPRTSRVLEDAAAKIGLPVRRGGTIVSIEGPRFSSKAESNMFRQWGGHLINMTTCPEVILAKEAGMLYAAVAIATDYDCWRDATDTVCAADVLTVFKKNVGKVTQLLVQAVELLAQENWDDHIDSLKNVLKTNNVSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK49</accession>
    <name>A0A232EK49_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003881">
        <property type="protein sequence ID" value="OXU18723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK49"/>
    <dbReference type="STRING" id="543379.A0A232EK49"/>
    <dbReference type="OrthoDB" id="7698948at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9145" checksum="7049E1DD1A840FE4" modified="2017-10-25" version="1">MKLQLFLKRKSAGYKPKKSAVFTKGNIAKFLNDAPDEIYLATKVVIIMGIAGALRRCEMTNLLTSDCLKGADLLLVSIKNTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL22</accession>
    <name>A0A232EL22_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003673">
        <property type="protein sequence ID" value="OXU19021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL22"/>
    <dbReference type="STRING" id="543379.A0A232EL22"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="919" mass="105955" checksum="2781FD0E2467A704" modified="2017-10-25" version="1">MEDDGTSKITEDITETPDDEVAQAAADEDTEFLEEPSAIGDKSVTISRAPSVAPSAAGTKSVTLSKPASASPSQLKKSRSKKKNPKAKKCAEPEKWECEEEALWRIYMRTFTEAASKRAEMERDSRGVFDRAKRRKQPADIPRLPDAETPMRFEFNAFNVQGRGFVDGSPKLSLFQLTDSSVMSIREDSEFEWPKLWPCSKRDIVREQKILARKERMKETGALPCEINEVDSPESSDDERLQELAHQKELVHARIPYTYPKKRSILLIDRASGEHPGLVDGDYVTFELLTKKGVPRTYANVCLRGLTGMHLAELERTRETTWKFCLYQALVALLTKTQLRYKFTWSANIDYIYQHAWMLFLHIGYLNVKPNQRFDDVLVYNYRYSVELELIQELKNVPVVPDVSFKYVEKSLQKQRQRPRKELTLARSGFGVEKQKDEFKLPVHKGTKMIEKWFDELEMQFTNCVIRTTRYSLAFWQDGPFWYLYNPYRCDKFGFWNDAGFASITKFCTRDSLKRHLMILMLRAYAYEASGDKSEDKENKSTASNKISEESKGFTIQIFQLIFHTCQIHNVKLYQRSPRKPKLKLVKKQESDLCTFDPLTKLSPMPCGIAPNDDKSNDKMEKPSWLQDYKITWSKSSSSKTNVQECGKPDTTKWHHFDVIESRRLYVLWGKIHITDRIFAEENRSRQTEACYAVCAGMSLINAPEYWSAEILNAIVVCGDKFYTDRRLKYPDPNDWSSNPTDHFLIGTTRFDLSTDPPIAGRLFVRTDQCLWRSLTRLFQNHRFAVLTCENSCLGLFKHCGAYYACDVGSYGPPVFDRGHGSAYLLRVSCFEDYVRCLVLLIGSNECSGFELRPLEIGRVVHVQGDECSGRKKVKCLEDVGVSRKDCPFENERSKGKKRGRRPSAEEKYDRVVCSKRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELL7</accession>
    <name>A0A232ELL7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003549">
        <property type="protein sequence ID" value="OXU19218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELL7"/>
    <dbReference type="SMR" id="A0A232ELL7"/>
    <dbReference type="STRING" id="543379.A0A232ELL7"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000059">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="248" mass="27925" checksum="4D8E01599AB11675" modified="2017-10-25" version="1">MARYDRAITVFSPDGHLLQVEYAQEAVRKGSTAVGVRGSDVVVLGVEKKSVAKLQEERTVRKICLLDDHVVMAFAGLTADARVLINRAQIECQSHKLTVEDPVTLEYITRFMASLKQKYTQSNGRRPFGISCLLAGFDYDGVPHLYQTEPSGIYYEWKANATGRNAKTVKEFLEKYYTPEEVSTDKGTIKLAIRALLEVVQSGQKNLEIAVMRRGQPMQMLDSDTIGDYVNEIEKEKEAEAEKKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMC1</accession>
    <name>A0A232EMC1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003395">
        <property type="protein sequence ID" value="OXU19487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMC1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="39" mass="4363" checksum="9ACF050ECE71DF0F" modified="2017-10-25" version="1" fragment="single">DTSAQTSSKSGKAQSPLVVHRAFYNKCIRKTIFDAYEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMC2</accession>
    <name>A0A232EMC2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003413">
        <property type="protein sequence ID" value="OXU19452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMC2"/>
    <dbReference type="STRING" id="543379.A0A232EMC2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="8664" checksum="DA670FCD7097F166" modified="2017-10-25" version="1">MTIKVTKDVVFVRFLRLYCTGCDEHIGSTSAEKHIMTEHSVLQILLCEMCQEFYGDAIFIHSLVTAKFNLSNFGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EME0</accession>
    <name>A0A232EME0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003382">
        <property type="protein sequence ID" value="OXU19507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EME0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="50" mass="5814" checksum="1E47DD6142B89834" modified="2017-10-25" version="1">MYSQANGKPSPWRVSFFYFFRSLTSAAAPRIHLFYGSRTTYPTADTYILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMP9</accession>
    <name>A0A232EMP9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003331">
        <property type="protein sequence ID" value="OXU19607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMP9"/>
    <dbReference type="STRING" id="543379.A0A232EMP9"/>
    <dbReference type="OrthoDB" id="10028922at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="440" mass="50633" checksum="0F89DEB1D81E15D2" modified="2017-10-25" version="1">MLLVTSIRLLSEKNPVQHISLAQVKLEEFVNRSSSLYGSFFVTLNVHNLIHITSNVERTGLNLNKLSAFPFESYLGEITSLIRLPIHVVAQYCKRLLEKKRYSNKICKKYKDFDIISQSKKETLKVSYQEATIRIKHPNNTVLLRNSNIVEIKKFLYVENILHIEIQHQKVIKCKNYHPCYYNQKYKCVNFRINVSKLKKKWCFPYTLVEFVTRGRTRKQWIEFNKTRQRGTTKFLTTIENEEDNRLLHDIVKNLSNPLESWTSDSVNILGDAASYEKAIQNISRLEVELRAFSLDSGEELEDRQSKILEEVKRQKLLKQSAALDDILAPPSKNVDSDNGNKPKSTFLNNDKKSTSMSTVKGPVDQDNVPTHLNQKISDNEPNNSPILSSEQHKKDSHKNFGASKNTNNGTAVFSSQLQNKNSSKSALMNRKKGPYVLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENT7</accession>
    <name>A0A232ENT7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003065">
        <property type="protein sequence ID" value="OXU20033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENT7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="149" mass="17233" checksum="AA9CD73195789C6C" modified="2017-10-25" version="1" fragment="single">KASSHVGEVIVGTDVKLLQDGHNQEIRPTQVAYKANSEDTCVQRLDLQSRDLADLNQLWVEHQKLKDPFLRRTGNPLRVEMYTKQALDAISNQKDIVLHLDATVRHEVGILKLDHMITCEYDTTSISNWLNDYKQFILNEKKNGHWQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENV1</accession>
    <name>A0A232ENV1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003088">
        <property type="protein sequence ID" value="OXU20002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENV1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="36" mass="4151" checksum="BC6F4EB0D5B49D74" modified="2017-10-25" version="1">MTLFTSILVFGFCMIQKKMLIVTVREFFGLSVCFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP00</accession>
    <name>A0A232EP00_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003022">
        <property type="protein sequence ID" value="OXU20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP00"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="423" mass="48370" checksum="6EC17BD776BA0504" modified="2017-10-25" version="1">MHTMTVHQGSAFTFANTNTITHIPQKFATSAHNTGTIQKHIIHGIPLSKTNTLNISIHNPYTGWQSNQLNDPRQATYIYPVAYSQNNRVLDNMRHASTPIHTPHHFIYSRQNEAFTTVPTHIYNNTNNRQNTNESRDMKITWDHNLAQPYLYIPEYFPESQLYTNNAVTTSRSSLESNFTQLTDNKNFESRQIPNNNVNFTPFKMQGNSNEQNIHDLNNPQYFETPENKITNPEQISLNAPIDIYQRTRGSTLSQALNLIPNFYGSPEKLHMFCMAIRQVRANFGSDSDKHIFMSLASKLAGKAADNFAARLLNYSSIHDFLSDLILQYSNIGLADKIMSQLKLITQMPGKKAGDYGIKTKKLLNRLTTIYESAPSIDDNDRMYRKRMANSEALQHFTFDLRSPIDHQFAAILNHLAKLLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP24</accession>
    <name>A0A232EP24_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003008">
        <property type="protein sequence ID" value="OXU20129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP24"/>
    <dbReference type="OrthoDB" id="8185397at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="170" mass="19792" checksum="7E15399D2973174B" modified="2017-10-25" version="1" fragment="single">MFNINWHLVIKRHRCVISNENLVIRCVVLGGVIVIIRPAPAGACIVALWRYQRILVVMSEITRVCLLGIARQLYTYGIAFSAMMCFREKEARMESREASTTYTPEALEAVRREEERRLVREGTEIWRARKEESLRQKQREQCELRRMLANYWPWGRPGGGAPCASALRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP67</accession>
    <name>A0A232EP67_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_013307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002993">
        <property type="protein sequence ID" value="OXU20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP67"/>
    <dbReference type="STRING" id="543379.A0A232EP67"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="6">
        <location>
            <begin position="579"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="677" mass="72762" checksum="D213F63DA66D82BE" modified="2017-10-25" version="1">MVTEMPSVRRMILGHVMSGMCAKINRKKKLEGDVMDTPLKRCLSTFDITLLGIGHMIGAGIYVLTGPVARDIAGPGVILSFLLAGLASLLAALCYAEFGAKVPKAGSAYVYAYVSVGEFWAFVIGWNIILEHMIVKGKLVPTGAASVARAWSGYVDSLSGRAISNFTKRLMSGYSMDEPLGNVPDPVAAALCLVYALLLALGVKCSAAVNSLLTLVNLGVMALVICLGFYHADLGNWNFQGHGFLPYGITGVFAGAATCFYAFVGFDSIATSGEEARDPTRSIPRATGLSMAIVTVGYILVSAALTLVEPYSRISRTAALPEAFAARGIPWAKYVISVGALCGMTTTLFGSLFSLPRTMYAMASDGLLFGFLARVSKRTQVPTINLAIAGFVSGLIALLFDLDHLVEFMSIGTFLAYTIVSASVIVLRYRPPPPPSQAMDNTVSSDTTLASSSTHQLASPANTDLAMDSSDCNSMCTSVESQLIQGFCTDGIGRVQPRYAWLSNFLGDCEPGTAVTTSIIFYSVACVSLCSLLVFLSQNTYSPAWWDYVMLINLVIILVASLLVIAAHQQNPPSLGCTFRVPMVPLVPALSILLNIGLMFHLSMLTWLRFLVWMIVGLLIYFLYGIHYSKEAVDPNSYAVLMETAEAERGAKWGSCSLRLNRKSDTTPILDSEEYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPA4</accession>
    <name>A0A232EPA4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003001">
        <property type="protein sequence ID" value="OXU20146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPA4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="10987" checksum="A4A9BD395ED6C52A" modified="2017-10-25" version="1" fragment="single">REDQKTFDLRIFALSCTLADLLTIPGGLEKSNLAHTVKRHESRTSTFQTLALPALPSFFLPIIDSSARNAITPANAHTPESPASLQTDSSESDRHVDIQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ16</accession>
    <name>A0A232EQ16_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002844">
        <property type="protein sequence ID" value="OXU20450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ16"/>
    <dbReference type="STRING" id="543379.A0A232EQ16"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="478" mass="53614" checksum="FC95C37F0C195980" modified="2017-10-25" version="1">MSYTKLKTLLEKHNQEHLLQFWDNISEKEQELLVNELTSLNIPEITSIFHRAKSSDDAKEQLIDNKIKPIPPNTIESIQQSSLEKLDSYENIGLQEIADGKVAVILLAGGQGTRLGVDFPKGMFNIKLPSERTLFHLQALRIKSLQNLAKRKLGKSKDITWYIMTSDATHDSTVDYFETNDHFGLNKNNIIAFKQGTLPCFKFDGKIILDDKYRISKAPDGNGGLYTALKNEGIINDMKSRGINSVHAFSVDNILVKVADPVFLGFCISRSADCGVKVVKKRSADEPVGVVCQVDEKYRVVEYSEILPSTAELQNDKGELVFNAGNICNHYFTVSFLDEIANKYENSLDLHIAKKKIPFLNESGNKIKPDKPNGIKVEKFVFDVFKYSNNFAVWEVIRENEFSALKNSNEAGVDCPSTARSDILNLHKRWLLNAGAKSVEGDVEVCPLVSYNGENLSDLVNNKSLQGPQCLMSSDYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER09</accession>
    <name>A0A232ER09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002674">
        <property type="protein sequence ID" value="OXU20804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER09"/>
    <dbReference type="STRING" id="543379.A0A232ER09"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000193">
        <property type="entry name" value="Ultrabithorax, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF21">
        <property type="entry name" value="HOMEOTIC PROTEIN ULTRABITHORAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="124" mass="14187" checksum="085005316EA6E944" modified="2017-10-25" version="1">MEPALSLSPQQSTKVFLIFVAGANGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQAQKAAAAAAAAAAHQQQGGPDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERC0</accession>
    <name>A0A232ERC0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002621">
        <property type="protein sequence ID" value="OXU20919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERC0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="11955" checksum="3FDF5BA4230A718F" modified="2017-10-25" version="1">MDHWAASTSKNLNSDPAGASTAGDSSQNPTEVVAGGSSGEPSGNPEPSQGGQVGMGVDLQRLPAGANTRTAGVSDTDLFSRGRRSFVLVLSYFSRTLSVEVSGFFLSFVLVGFNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV15</accession>
    <name>A0A232EV15_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01002063">
        <property type="protein sequence ID" value="OXU22187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EV15"/>
    <dbReference type="OrthoDB" id="7692176at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="69"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="254" mass="29233" checksum="A327E2565506A18C" modified="2017-10-25" version="1">MHKNLKQLRRFLGMASWYRKFFEDFATLYEPLTALTRKNVKYEWKDEHWAAFEQVKALIATAPVLARPDFSAPFIVECDASDTGLGSVLLPRIDGENRVLCFASRVLSATELRLSVTKRESLSVIWSIEKFRPYIEGYHFTVVTDHHSLVWLQNLKHPNGKLGRWSLRVQSYDFDIVHHKVKDNVVPDALSRMYETDGDETAAIASLSVDESIKDPWYSKKAKQVVEDPTVYPXGSPNRMWAPELEQSTVITFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV54</accession>
    <name>A0A232EV54_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002062">
        <property type="protein sequence ID" value="OXU22198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV54"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="8285" checksum="01C445C371666039" modified="2017-10-25" version="1">MKHLEKPEASQMRSPLAGAEQRRTPRVKPQQKRAPSKHPKGHSKKEAGKSFPPSNGPRFVERVETVTTFLGPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVX5</accession>
    <name>A0A232EVX5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium/calcium exchanger 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Na(+)/K(+)/Ca(2+)-exchange protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Solute carrier family 24 member 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSAR_004251</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">Alberta</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001938">
        <property type="protein sequence ID" value="OXU22504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVX5"/>
    <dbReference type="STRING" id="543379.A0A232EVX5"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000015">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF70">
        <property type="entry name" value="ZYDECO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-0769">Symport</keyword>
    <keyword evidence="9 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="26">
        <location>
            <begin position="50"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="26">
        <location>
            <begin position="312"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OXU22504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="481" mass="52807" checksum="F61897932A8F7716" modified="2017-10-25" version="1">MDSTSNLGGGYIDHHRTINGSNCTQPAIEDFPHDLFDEKQRQAGAVVVHVLVSLYLFIALAVVCDKFFVPAVEKICHALSMSKDVAGATFMAAATSAPELFVNAIGTFITEGDIGVGTIVGSAVFNILAVPACCGIGAGMQVVPLDWWPVSRDCLAYGVTVAILICIIHDERVEWYEALSLVLLYIVYIAVMYYDKSFQRCTRFRRKNSAAPEDLNPRPGDAGEIHLSRSDKLQSSADRVEQIATIDVPLQNGGTKTQEENHAPEYEYQLLVWPSSAGWIRKTAWVLTWPIHLVFMCTIPDCDKPKFKKWFPITFLMCIIWIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKQGHGSMGISNSIGSNTFDILLCLGLPWLIKSSFAPTLKGQHYISINSGGLEYSAISLLSTLLLLYVAFAANRFQLDRKVGRACLCMYAVFLILATLIELNVFFRVNLPTCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWN9</accession>
    <name>A0A232EWN9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline-rich nuclear receptor coactivator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001833">
        <property type="protein sequence ID" value="OXU22767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWN9"/>
    <dbReference type="OrthoDB" id="6358215at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026780">
        <property type="entry name" value="PNRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15405">
        <property type="entry name" value="PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU22767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16167" checksum="58A84D6E586824FE" modified="2017-10-25" version="1">MTNSTPKNNDKIERQGSPSSQGKQRRSSNYVKTVTYFSSGNNNAAGASSVAVTGNNASGRNSRASNSSRRQSCSPPCTSAKNIPRSSPMRYDSPRGSPTNNFYAGAKFSEPPSPATLPKPPNHWTGLIGSCGSETGPSHISQHFNMFLNIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWT1</accession>
    <name>A0A232EWT1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001823">
        <property type="protein sequence ID" value="OXU22807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWT1"/>
    <dbReference type="STRING" id="543379.A0A232EWT1"/>
    <dbReference type="OrthoDB" id="9998343at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819:SF3">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU22807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="349" mass="38788" checksum="E69766C3DEBB6C48" modified="2017-10-25" version="1">MADKCVETVLGPVKASELGIVLTHEHLALDFDKFYVPPPKLLNEFVNGKIDLKNVGVLKQYPYGSKYNVRFNDTDSAAAVLEDVKFYKKSGGGTIVENTSHGIKRDIPLMQKASRESGVHVIAGTGHYVALTQTTPSLAATEEQMYNLIAQELTVGCEGYPSVKAGFIGEVGSAWPIEDFEKRAIRATAHAQEQLKCPVSFHPGRDAAAPFEILRIYLEAGGDAKKAIMSHLDRTLTKDEDLLEFAKLGSYCQWDLFGVECSYYQLHVPTDMPSDAQRIDKIRLLRDEGTVDRILMSHDIHTKHRLMNFGGHGYAHIINNVLPKMLVKGFTKEEIDTITIANPRTWLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX78</accession>
    <name>A0A232EX78_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NOC3-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar complex-associated protein 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001141</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001788">
        <property type="protein sequence ID" value="OXU22923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX78"/>
    <dbReference type="STRING" id="543379.A0A232EX78"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="10">
        <location>
            <begin position="98"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="9">
        <location>
            <begin position="433"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="678" mass="79047" checksum="3A8B12BE1E2D5288" modified="2017-10-25" version="1">MEVEKRYERLVNKSRVSKDTEKVRHLLPIKTKEGRLKKRHTSEPDPVDDEQDERTDTVLSEKFADNNVESTVDTPPAKPISTVQLLAYREEKLKYVRYHIGILSSEILENPEHKLSNLSLLLKYMDERNPEVYITVTKLATASILEIFKDLLPSYNIWSFDKSEVKLKKETLLLQNQETALLKYYRQYLQKLEKMASAIKKTKHKQIVKKLDAYLAMFAIDCMSKLLVTQPYFNFSSNIAHFLIPFLDNKHPNVRETVAKCFRQIFKEDLRGELSVSIVRHLNQYVKVHKLSVHLEVIQILLSLRIKDINLDKNKEETSNYKKLVSHKNRVLALSKKERKRKSKLEQIEKELLETKAEENKQSQSKTFTEITSLLFTIYFRILKNAPSGKILSSCLEGLSKFSQCINIDYYQDVVNQLNKLLDEEKLSFVERIHCINAAFKILSGQALALNIDPIRFYTHLFRIMLQISVGQKHMHAEVFTESLSYILMNHSNNITQNRLLAFLKRLFTMMLNVQHNTILGTICIARLFKQHFKITSILLDTENMGDNIYLADLNDPEYSNAGSTSLWEVVALQRYYHSSVQNIAKIIFQNAPLKMENTVAKNIIKSTPKDIYVEYDSSRGTFHPAITKPKIAKVTRLRKNDLSARFEDLPDIINSHKIFDDKYVDLFEELRHNRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXG4</accession>
    <name>A0A232EXG4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001763">
        <property type="protein sequence ID" value="OXU22987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EXG4"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="365" mass="40039" checksum="AF5EA524DF685AC5" modified="2017-10-25" version="1">MASVRDTATFFAEGTASQFEHVLKLYPQALRLKAENHKSKKPEELIKLDNWYQNELPKKIKSRGKDAHLNHEELCQTMKWKQIRGKFYPQLSYLVKVNTPRAVMAETKKAFKKLPNLEQAITALSNLKGVGTTMASALLAAASPENAPFMADECLMAIPEIEGIDYTTKEYLNFVQHIQTTVERLNKQNTNGTKWSPHQVELALWTHYVASELKPQLLEGIPEGNGDAAPPATENGNSHSASNGEXXXXQQRGVRGDYRHDDCAEPISNGKASEPAASLDDNSTTTSFTEDSLDKPATPVSASTTPAAALNAEENTNDSLPTNEDSSNQDAATPRPTDESGEELATEEDSSQDSVQEPPAKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXZ6</accession>
    <name>A0A232EXZ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001640">
        <property type="protein sequence ID" value="OXU23346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXZ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="399" mass="44016" checksum="583F19D86108C6E3" modified="2017-10-25" version="1">MALQQRLSRELANLLLSTPSYLNRPQVQRSRLQLFSSLLSRDIDSSEKKRRREDDCPSTKRTSIKQDVGSPTLAAAVSSLIGDKPYGVLLSALVCRLPDKLIRDVMPAQGPWSPQRAPEVGKFNFPQQKSNCPVFDDPCGESSCSFDPRAEKTLLSTGLYPRNWSRLQTRGLHASALKCGVGRGHSNGKSNRNKSQKAAKKPNNSKTRKGPREKKPSDQKFTSCEPDVGWKRHKCLGDSRGSDTCSVDKPQCTEKVGPTYRELEKSHEDKRMKAWKQSKSSSSDKCQPDDSWKESKTCTKSSESCSTGKPQCGGGKRSYSTLPRILLNFQSTRSLMSGGGLSRECNSGGGDNKDKSIGDVFKKEMQEIEECIAAAKCKIPMPKTDKSNGEGNSTKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY74</accession>
    <name>A0A232EY74_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_005841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001667">
        <property type="protein sequence ID" value="OXU23275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY74"/>
    <dbReference type="STRING" id="543379.A0A232EY74"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF208">
        <property type="entry name" value="PEPTIDASE M13 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012872930" description="Peptidase M13 N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="92"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="553"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="88428" checksum="4C3AEF361AE020C0" modified="2017-10-25" version="1">MKPRHSNHAASSRLFLLFVIAACASAIPTRRSRISDEDEGELFAKAYHRHRQRAISSPYLVSYEFTENVCTDDRCNDVAELFLKSVKKSMNPCDDFYGYSCGRKQSKMPSITKEIKEILEQQSAEKEETKSLALERRLYRSCMEQQDGEQKTKREFTRLLELSDGLSLFRREKGKGDKKKVLDWQSIDNFYASLGFENAFFNVHVTRDPRAEEDDADDSDDVNLISLMPPSPLYFYSVHSLLKYKNLTGIVSNLLQPDDAESYVTDYEDVIGFNNALHEILPPLGMFEENVTSLISNKMTVAQWQSVYDSVIDDQGLERPAEKNHIDWLRLLNSLLKTANVRIDKHDYIVLKKLDYFTKLAELLDRTSPITVEKYIHFKFLTQISKYLSPSLARFFENIPDRSTFCIKQSDNQLIGATYEYIKRHVPHEQKVYAIKRDFTTQAEEVIQNIREALSDLLSNAKWMDNETKTYAINKLKHLKIVVGYPDWQRDKKLVNNYYGNLHLHSNFFENIIKYRRRVLIHELRGLKHPHLFDPNTMSKKFVPLMYHFEVNSHTNRILFPTEYLNENKYKLFSPKLPSAINYGSFGSMLGSILYDYVSLTDNLKYNEFYTRTIEGLSKDTIDAYKVKEKCLSNQLINYKKSASKFDQPLASVIDRDTIQVDKIYEKMTGLRAAFEAYRKVESVTSAELLPGFEDMSQQQLFFLSYAERICEIGDIYDNYDAYETSLKVNGVVANLEAFSDVFLCTKDSPMNRQTKCELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYG1</accession>
    <name>A0A232EYG1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001628">
        <property type="protein sequence ID" value="OXU23385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYG1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="31" mass="3529" checksum="C4D2443505BF8455" modified="2017-10-25" version="1">MYSKASPVYAMPRDGCSTLPRCWTDLARSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZF9</accession>
    <name>A0A232EZF9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">28S ribosomal protein S6, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001464">
        <property type="protein sequence ID" value="OXU23886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZF9"/>
    <dbReference type="STRING" id="543379.A0A232EZF9"/>
    <dbReference type="OrthoDB" id="268530at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000014">
        <property type="entry name" value="28S ribosomal protein S6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17883" checksum="2A267AB13CCD9855" modified="2017-10-25" version="1">MPAYEMPLLLKIMTRPELVVTLKRTAESIFKNGGFIRKIDNLGKLATPYKMSANNETHKEANYFIIHFDIPPSKLAILNEECQRDIDIVKCKIYNKNEDKKIKCTLHEELLPPAYRPQVQQMLAIGAKQQARKDKIKHKFKFNTGLDYYPFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0B3</accession>
    <name>A0A232F0B3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001466">
        <property type="protein sequence ID" value="OXU23868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0B3"/>
    <dbReference type="STRING" id="543379.A0A232F0B3"/>
    <dbReference type="OrthoDB" id="5918429at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030877">
        <property type="term" value="C:beta-catenin destruction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026818">
        <property type="entry name" value="Apc_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607">
        <property type="entry name" value="ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12607:SF12">
        <property type="entry name" value="APC-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="523" mass="59433" checksum="6C9C28312DF9FF05" modified="2017-10-25" version="1">MTTRVARHASKKAPTSVNLSTKLCYFSNFIETDFDQTTNYSLLYAEENSVIEEVGHFDYLAGGSEQENTITTYYTEGTPFETPPHFSTSTSTSDLLKLDDTRLSYTFQADFKELITDNQTTELIREKLEKLNEIDQLQSYMEFENKEKECESTDINIYLPDDLEDFDDKCDEEPLERIINVTPSQSPVELCDKDREGKMVTFGGEDRYSHQTPLMFSRCSSLGSLSGYEQQSLHDDRSSVVSDFSRRTSEAVSPSELPDSPAQFVHPGSTQPRDKKSVRKKSQQMKDKVQSPETFSAQPETSKRSIFEDDLSVFKEESTPIRFQSVAASSLSSLTIDDDDEADEQDRGEMKNKAGIIKSSKVSTTNNQFESIDETERRKPDNNVESLEENSYISVDEEKILDEYIRKGIAKVTRQDINDVSSFNLQDANAYDSSENKTHSSLELFDEASELTAEEEKLLDECIRRGIAKVTRQNIDEVTSLSLRSNISGLSTISSFNKDNNKQEKEQQKHEETKKRTAVCQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1F7</accession>
    <name>A0A232F1F7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">maleylacetoacetate isomerase</fullName>
            <ecNumber evidence="5">5.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_012806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-maleylacetoacetate = 4-fumarylacetoacetate</text>
            <dbReference type="Rhea" id="RHEA:14817"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="EC" id="5.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001358">
        <property type="protein sequence ID" value="OXU24248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1F7"/>
    <dbReference type="STRING" id="543379.A0A232F1F7"/>
    <dbReference type="OrthoDB" id="5339429at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="11">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="12">
        <location>
            <begin position="297"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="13">
        <location>
            <begin position="385"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="509" mass="58110" checksum="53528D858D8D8DA2" modified="2017-10-25" version="1">MLSRKNKDLRTIKEGVVGKYVKKDTPPEMPIINVWTTEPNRRGRRLNQPAITSSMPISSQQPTMVQKFGNTKSTLSAVGLGSHEGKYTPNSSVPDLAQRFASLSMNSASSDGMPSRTATPLYQPSLSPAMSHTYVNQYAGSEYHLDRDQQTPQLPYSYDIDSGYDDYNSQTQYRQNTGYSHAVAERPSSRNEQSEELPLPLGWSVYFTLRGRKYYVDHNTRTTHWSHPLEKEGLPTGWERIDSQEYGVYYVNHITRQAQYQHPCYPSEMQAVRVVPPPQHTNFHSHSVLVPANPYINEEIPRWLYVYSRASVDLDPLNLKEIPYDIKPISLVKNGGEQHSNEFREINPMEQVPALHIDNHTLIESQNILLYLEETRPHRPLMPVDPVKRARVREICEVIASGIQPLQNLIVLIYVGEERKKEWAQHWITRGLKAVEKLLSASAGKYCVGDEITLADCCLVPQIFNARRFHVDLRPFPTILRVDRHLENHPAFTAAHPNNQPDCPPEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1J1</accession>
    <name>A0A232F1J1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc carboxypeptidase A 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_012888</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001310">
        <property type="protein sequence ID" value="OXU24399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1J1"/>
    <dbReference type="STRING" id="543379.A0A232F1J1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF153">
        <property type="entry name" value="ZINC CARBOXYPEPTIDASE A 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012534009" description="Zinc carboxypeptidase A 1" evidence="16">
        <location>
            <begin position="19"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="120"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU24399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="449" mass="50900" checksum="1B90C9AF94F83ABB" modified="2017-10-25" version="1">MLFVWIALVALSSTGTYCQQASFRNYQVFRIVPSSLEQLEVLRQLEDTGNAGGYSYWIGPSFVSSKVDLMVAPDHLDEFTELMNATDMSYHMYVKDVQKLIDQEQRSSEIRQAGSFGWTSYHTLDEIYAWMDQLAKDHPDNVELLVGGRTYQGREIRGVKLSFGSEKPGVFVEGGIHAREWISPATVTYLIDQFLNSQEPEVRELAESHDWYMFPSFNPDGYVHTHTSNRLWRKTLSKSGILCKGADANRNWGFKWMSGGASRNPCMETYAGKSAFSEIETRTMSEFIKSLSGKLFAYISFHSYSQLLLFPYGHTTEHLDNYDESVSATIALYYGSYVIYQCIITTFRFIQQKAMGTKAITALARRYGTKYTTGNIAETIYVASGSSMDWVKDTLKVPVSFTYELRDTGKHGFILPADQIIPNCEEVLDSFVAMFKEALKLGYPKTSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1T3</accession>
    <name>A0A232F1T3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001222">
        <property type="protein sequence ID" value="OXU24691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1T3"/>
    <dbReference type="STRING" id="543379.A0A232F1T3"/>
    <dbReference type="OrthoDB" id="515366at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF19">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="138"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="312" mass="35510" checksum="ECD28FC91DA5BA7B" modified="2017-10-25" version="1">MDPKHDPAFMEILREEKNIAGFLDSFFGFLYRCTDFYVEAPPDQRLGFPPGVAEQLVLTSLRKWKNIKNLSEFSPTKAEAVPPAIEEVTVGGDGTIEATEDKHSIKVSIIPYKKIFIFQLTIESQSSGPSVSDCYNGASYDNYRWSQSIGELDAVVHLPEEARTSKDVQVRLSAEEIEVAAKSSEEGAEAWKTLLKGRFSFKIKSSESYWCLEPGKHISLHLEKASERWWESLVDGEPRIELSKIDCSRNLEEMAECEQMKVEELMWNQRRKLLGQPTSDQIRMEKILQLAWNADGSPFKGTEYDPSILKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F252</accession>
    <name>A0A232F252_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001273">
        <property type="protein sequence ID" value="OXU24538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="12808" checksum="ABC1D2F8E6764D7B" modified="2017-10-25" version="1" fragment="single">LVGLPLHSTASRLNLSLTGLLVSTTAIPAPSIHPHSPSLVRRSLSGLISWPPHLEHVSIILSDSLALINLYKRVARFSLGALGLXXLVYGLIRRPLLSSRIASLSLSLSLSLSLPQYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2I4</accession>
    <name>A0A232F2I4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001130">
        <property type="protein sequence ID" value="OXU25036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2I4"/>
    <dbReference type="STRING" id="543379.A0A232F2I4"/>
    <dbReference type="OrthoDB" id="6348149at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="638" mass="70360" checksum="691A87BFA8981EBC" modified="2017-10-25" version="1" fragment="single">MQTEEIVPSAQSTSLDASSSVSDPIGSLFQSHQPQIQFSQHIQYPIPSLVNMAVKQEPQEEDEQGRQPNALSPQTEIGDAQSTPEVSLANHKRTDQASPEFNSQSPQTPQQNGCKKPASRGRRKSRWKLKFHHQALPPEYLDHYEAALAQEAALNSTSAAPRLAAMQNEIYANPLQAANLCQTTAASRRSVITSTQSTQPQLPSHSVFPHHPHHHQPPQQQQTLPSHRSNVQAQPSPRPPMKYSDLPYMGEITLDNSKPRRGRKPKKADICHLIYKNYGTILPGTPGLDDRSKLPTTRDKLDLSKDAAQLSTPYQRTDIQNRISSLLEKRLTQERRALEISVDNACREQEEPLNLCIRDLNLLKIRLGEKHGSAYGSCYSKSEGSSDAEDAEVNGELGASEQQLKSINPNHMHYGGEANEVNGSGADLLNNNHELAAKPNPGFLYWPNAGVFIHPVALQSQFLYYQKLAQEKGLAPPQPPPQPEQTPKEQRIVPKSIYSMLESPKTPVPVPSALSPSQTPLSPEASIPQTPSPRPKRNSTSHGGQTSSLQQPMKRKRSAIFIPPMPTENNNNPATEVSICKFKFTGGAKPTLQEKKSLSVDSGGNFRYYSGTGDKSMRGYEFFPREALQQPANQAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2I9</accession>
    <name>A0A232F2I9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the POU transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001218">
        <property type="protein sequence ID" value="OXU24698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2I9"/>
    <dbReference type="STRING" id="543379.A0A232F2I9"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002805">
        <property type="term" value="P:regulation of antimicrobial peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF76">
        <property type="entry name" value="PROTEIN NUBBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="11">
        <location>
            <begin position="149"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="243"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="245"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="332" mass="37104" checksum="8A0ABCB85ADA307C" modified="2017-10-25" version="1" fragment="single">MCKIDVRVKGVEADEEACSLARKMVFLEEPRMIFADMKFHATSTPTSYRAHHHHRKYRPQNNNDCTSKFESAFFHKIFHDADLHGDVDGADLSGDDRSIASDVQDGNDVHLDHDSIDSDREALNLRSPPPPGTPPAVKPSAARLEPSPEETTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLEDADNSLNNPNSLSNPMTTPEAIGRRRKKRTSIETSVRVALEKAFVQNPKPTSEEITILADSLAMEKEVVRVWFCNRRQKEKRINPPTAAMGSPTMASPAPSVFASLASTMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2S6</accession>
    <name>A0A232F2S6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3 11">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004661</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3 11"/>
    <dbReference type="EMBL" id="NNAY01001171">
        <property type="protein sequence ID" value="OXU24892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2S6"/>
    <dbReference type="STRING" id="543379.A0A232F2S6"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU24892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="750" mass="84681" checksum="432E665D9B2EF605" modified="2017-10-25" version="1">MGRTVTVAVCTLNQWAMDFEGNSRRILQSIQTAKEAGATYRSGPELEICASDEVIESMIGYSCEDHFYESDTLLHCWEVLAGLLKAPECEDILVDVGMPVMHKNVTYNCRVAFLNRRILLIRPKMYLCEDGNYRETRWFSPWTKERTVEDYFLPRMIAQITNQTRVPFGDAVISTRDTCIGFEICEELWNPSSNHIPMALDGVEIISNGSASYFELRKAYITIDLVKSATFKSGGCYMFSNLRGCDGTRVYFNGGSSITLNGHILNRGKQFALEEVEVTLATIDLEDIRSYRNSIRSRSHLAARSNPYPRVEVNFALTSENLISNPPDRPIDCDEDTYTKIEYHSPEEEISMAPACWLWDYLRRSCQGGFFLPLSGGVDSSSTACLVYSMCCMIVESVNKGDMQVITDIRKIVGDPEYIPTDPKQLCNTLLVTCYMATENSSAETKGRAAELASQIGSYHHSIVIDTAISAILGIFQQVTKLTPKFKVQGGSPRENLALQNIQARIRMVIAYLFAQLMLWVRGRPGGLLVLGSSNVDEALRGYFTKYDCSSADVNPIGGIAKNDLKRFLAFFRKKYNLPAIDQILEAQPTAELEPLQGGQLAQLDEVDMGMTYVELGIFGRLRKQNCAGPFSMFCKLIHTWDNITPKEVADKVKHFYRCYAINRHKMTILTPSCHAETYSPDDNRFDHRQFLYNHTWKWQFNAIDEQVQKLNSEDRTTRPRKSAPKVPAKPRFMSISSVVSNKTHPGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F322</accession>
    <name>A0A232F322_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001104">
        <property type="protein sequence ID" value="OXU25121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F322"/>
    <dbReference type="OrthoDB" id="7634903at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013302840" description="Odorant receptor" evidence="11">
        <location>
            <begin position="16"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24188" checksum="8F87757499BD9C40" modified="2017-10-25" version="1">MFLCVIGFLLTPIFGLSIRVINNITDVASDRFLPLQTCYPIESSRSPYFELIYATQLVAGSFVRFSFSVPDNFFGALVFHASAQCEILGERMKELLDGQVDGKRLFRRRLGRLVDTHVHLLRYSIPVCFVCVDRFVDAVEESFNLVILAQVLCLSLIICCLGFGVIQSIASDDNENPPIVQAATLAGTLLNLMIHMLVYCIASEILAEHASLRLYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3J4</accession>
    <name>A0A232F3J4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001093">
        <property type="protein sequence ID" value="OXU25152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3J4"/>
    <dbReference type="OrthoDB" id="6435470at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="113" mass="12732" checksum="EA22A4B7B1342F6D" modified="2017-10-25" version="1">MNSASTECQVSQFEPLSDSCGESDMEGLDLSLFEPQADANSWCDSRVHAGFLYLLVHYCAFDQQSSHYAVINTSNQPFAFQYPLNNAQNTTLYLKKEYTKELPPMKMSPSLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3S0</accession>
    <name>A0A232F3S0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001092">
        <property type="protein sequence ID" value="OXU25159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3S0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="215" mass="23938" checksum="9E277DCF2D6A03A5" modified="2017-10-25" version="1">MANNNNKRGYKQFLQTGQIEDVSTDTLRRTRRKFEKAKNLQNSKNETKCDSDDLLSNNATDEEKQSESVAFADPECVQNCFNDDILNIHEAGTNEESIDLCDSDDLLSNNATDEEKQSGSVAFADPECVQNNFNDDILNIHEAGTNEESIDLNLQNSKNETKCDSDDLLSNNATDEEKQSGSVAFADPECVQNNFNDDILNIHEAGTNEESIDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4F2</accession>
    <name>A0A232F4F2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001033">
        <property type="protein sequence ID" value="OXU25409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4F2"/>
    <dbReference type="STRING" id="543379.A0A232F4F2"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="568" mass="62859" checksum="48AD8E9E5AE31898" modified="2017-10-25" version="1">MADSGPSKSDIEEVFKRLRSQPANKSCFDCNAKNPAWSSVTYGVFLCIDCSAVHRNLGVHLTFVRSTQLDTNWTWLQLRNMQLGGNANARKFFAQHNCTTNDAQQKYTSRAAMQYKSKLAQSSQQAMQRYGTKVQLPSPQSKLLHVEDYVEPETNQNEVDFFEEHENFDVNNTETVVPHVHEDTVTQLLNEDHKIHATDNIHAVPETIEPSTEALGPSVNISDSAMLGAADRKPTIGGRKVPPKRPGGLGKKASGLGAQRIQTNFEEIEKNAAEAFKERREAAAEPPKNEEEKIEIEQRLAYRYEQNLTEQAKKVEERTRKMDPSRASQAERLGIGFNTKRGASHSALTDMQTIAQESSSKLITASEPKMRDMNLDIRDLDYLISGFETLTNTFPSGASSSNSSSKPRNDEYIIEEEPDTARRGVTSSFSNLSSSQSTNKSYNKTSSSGSSSKQQMDEGQAQKKFGSAKAISSDQYFRDNANDNNWEQKNNLRRFEGSSSISSADYFGTGQSNPTSPTSSLSMNIGGRGGVDFDDVRESVRQGVHKVAGRLSSLANAAVSSIQDRYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4J3</accession>
    <name>A0A232F4J3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000965">
        <property type="protein sequence ID" value="OXU25704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4J3"/>
    <dbReference type="OrthoDB" id="8180835at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012963536" evidence="3">
        <location>
            <begin position="23"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="461" mass="52076" checksum="369AD7993D42787C" modified="2017-10-25" version="1">MWNRKVCIRVIELLLCIACVVALRVTDDESRRVFHYLRNRSLEWSLLNNVTWGSIGAALATATCGGYIIVTAGLLIAAASGELRGRVTERCLLGLGVILFGIVGALSMASIDSVPNDLIDNAAVLGTLCLVTAMVFIADMLMSPVVGKKKHDGTQTISSKEQAKQYVTTTTMTINEKEPNKKVSTWRSPTHEMTEKRNSMNDSVVEDDDRDDREHRLERAERQMREYAQNIENGRGARGKPLRDRDDMPRKMNGYYRNDDVYQRPVDEVDDAPPFPTNGDTPVFAKVMNPGVKIMRVDRDDERGYDNYRQYLLPDFFRPVYRRHAGAKIACRYSDSSQYDNVPTRMRGSSPGILKRQRDVSFSDPRRSRGYRPQEMDEDHPGQQRRQHRGTRDEIEMLEESFDALRTSTMTTTSAATQTTGADRKTSTATIMVGAPVTPNDPGYVRHMSSNWPQNLKPKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4V2</accession>
    <name>A0A232F4V2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000940">
        <property type="protein sequence ID" value="OXU25811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4V2"/>
    <dbReference type="STRING" id="543379.A0A232F4V2"/>
    <dbReference type="OrthoDB" id="6610237at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012263223" evidence="2">
        <location>
            <begin position="28"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="686" mass="76478" checksum="882F23A484DADB6F" modified="2017-10-25" version="1">MALRLLRCLLAVNIGVLIIVVNDCARASEVDVRPTKMWRFLGNNDEAVLQRFRENIDEFSVGRIKCLRYCIQSRSITDESPHVLHLIWKLGMKHTSEMGSAAISDRDFTPEILQGKSIKSDDSWNLRSKCTFSIVIGCELSRGLEDNVSKVEKNFIKSLQPNLEDSDDNGSSTLNFVSEKLVDKSGLTNATEIEFSVQPDQAEISAIILGNVSKIDLKMPIGNDASLGSTTRTTPPRLTLATSRMPVGLRLNVLNPPPGGWRLGVDGGEGYRLIVTSALVPAFFEGKDSLDRLVDDGMRVAALEAEDPQTMHKDAGISSRQIRVLNENREQLDVFNDPESNREFSDSMIADGQSLVGQVEPKSFRFPEVKNDVDMMDTSTNFTSRMNTDLIEDRMIDRGSLELDDLTRSNSNELPIKKHLMVDLNPSTNLIANPGTIHQVTFDITNNHILMIKHYFVPKSSFFRIVSVRPLSDYILIPPGQTISVRVDIQVPPTVSESVLNTVSLQVQGIETLEKTANIYVRSAGSRVFDDVRPTIYYYFNNNCAGRTNAEKCLKSYWSVDITIQDSESGLKSVTSTPRGAYPRSQYVSGTSSPVYFYYSNNCCSRVVEITATDVSGNVYSRRIDVGEWYNLTEGEIAAVVIGVLFIILLIILIVISILYCTNRRSSHDLPYSQRYGSRSAPRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F524</accession>
    <name>A0A232F524_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 865</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_012419</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000993">
        <property type="protein sequence ID" value="OXU25579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F524"/>
    <dbReference type="STRING" id="543379.A0A232F524"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002110">
        <property type="entry name" value="Zinc finger protein 1053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="16">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU25579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="585" mass="67397" checksum="424C075CB0309452" modified="2017-10-25" version="1">MFIVTKTIDSENISKVCRTCLREDNDKMVCLFIGPAESSLGAKLQSLSCLEVAQGDGLPEKMCDRCVTRAESALLFREQCRAADQALRQAAVRVSKERVRQNVLPCKAYQQTPSFVPFQYSQEALKPSDCRALANHQELYLNNRLHPPFYRGEDNVPQHMHIVESHNNYLNLSRYSGGSTSHESLRPDDFDPITRHNTIQNRASCALQCSLCHCTFTNRTQLENHCITHNSDNVDISSDEVNIEVEENSNHLERNHSYERCVSQSVQQPSESIAYNKMKPDCGSSFQELTFSNSIKGKYSDQVSVISTRVISQEPESMARSKPQEIPEKNRFKCETCSRLFGQKSKLLAHQATHDRKKPFECMDCGKSYSSRSKLTSHSRLHTQTNIHRCKICQKIFSYPSYLADHMKSHDAKPVKRTASIECAQCKKQFQFAKSYKRHMKFHTGKDLFHCDICDKLFNQKYALKAHMRSHESARFHKCDLCDKSFNQKSNLVEHMRIHTKVKPFKCKTCEKSFAQSSHLKSHEASHDSVRQFQCRMCGKRFKLASHLKRHVNLHTGLKMYKCDQCEQVFSQAFSLKRHSKKHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F537</accession>
    <name>A0A232F537_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000913">
        <property type="protein sequence ID" value="OXU25946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F537"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="42" mass="4853" checksum="815E98A43E73B164" modified="2017-10-25" version="1">MAPWRVNNRDLDFDLPLARGWVVKVGFCLPSPWCPDTTYMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5R5</accession>
    <name>A0A232F5R5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000865">
        <property type="protein sequence ID" value="OXU26154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5R5"/>
    <dbReference type="STRING" id="543379.A0A232F5R5"/>
    <dbReference type="OrthoDB" id="1060944at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24333" checksum="E88E7997165619AB" modified="2017-10-25" version="1">MKPPAYNNSEDQVQQISQEQGERNVAMAVCVQLAGRAIIRVVSRCEEAQDNCQLDLSECQLMQVPDAVYHLMRHTELKSCDLSGNVITKIPPKFAVKFSLISELNLSHNQMSKLPEELSELQALERLDISHNAFIALPMVTCRIPQLKRLLANNNSIIEVDIELLRHAPQLELVDLRDNPLPSRTHDHLQNLSMRLKIELSPRQREEWEDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F659</accession>
    <name>A0A232F659_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MRN complex-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000823">
        <property type="protein sequence ID" value="OXU26324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F659"/>
    <dbReference type="STRING" id="543379.A0A232F659"/>
    <dbReference type="OrthoDB" id="5960226at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032739">
        <property type="entry name" value="MRNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049472">
        <property type="entry name" value="MRNIP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15863">
        <property type="entry name" value="MRN COMPLEX-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15863:SF2">
        <property type="entry name" value="MRN COMPLEX-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15749">
        <property type="entry name" value="MRNIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MRN complex-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="207" mass="23662" checksum="2070987EED85B1CA" modified="2017-10-25" version="1">MPQEAWVLKCYSCNKFQVQLKKNAKKWQCKVCGSKQDLITIYFKGSTSDCRVNVQNMNAAEGELLDKQPEQSDIGDEYCDDDDIENISQNSQNSHNLSFSCEDMDEFSNSVLEADISEPCVKSDEDYFQRIYTENPNEKENGSLASNTDLLKNGPTDTNEYDFDISTIDFTIKTYRESTSSSTDKRNQPLKLSIFESNSNFDESLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6C3</accession>
    <name>A0A232F6C3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000905">
        <property type="protein sequence ID" value="OXU25989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6C3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="74" mass="7817" checksum="FD3DCB3CD44157F7" modified="2017-10-25" version="1">MSPQTASRVICSGWSHRSGDREAAGDLRRSRSSTCESGALDAYATTGLDPLSQAAIGSLPITSDAMCRDRDMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6M7</accession>
    <name>A0A232F6M7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000869">
        <property type="protein sequence ID" value="OXU26130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6M7"/>
    <dbReference type="STRING" id="543379.A0A232F6M7"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14218" checksum="5A84689734383749" modified="2017-10-25" version="1">MADNNDMDTSEDQTVTDDVKTAGQPLSDFLLQLEDYTPTIPDAISEHYLHTAGFNTTDPRIVRLVSLAAQKFISEIANDALQHCKTRGANQNTKTKGKDRRYTLTMEDLTPAVAEYGIIVKKPHYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6Y9</accession>
    <name>A0A232F6Y9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="37">Trifunctional enzyme subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="36">1.1.1.211</ecNumber>
            <ecNumber evidence="6">4.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="38">Monolysocardiolipin acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="39">TP-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="45" type="ORF">TSAR_004117</name>
    </gene>
    <organism evidence="45 46">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="45 46" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="45 46">Alberta</strain>
            <tissue evidence="45">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31179"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
            <dbReference type="ChEBI" id="CHEBI:62615"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:31180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:62558"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="30">
            <dbReference type="Rhea" id="RHEA:31077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
            <dbReference type="ChEBI" id="CHEBI:62616"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:31188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:31160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:31165"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31195"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
            <dbReference type="ChEBI" id="CHEBI:62619"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:31196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:31199"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:62617"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:31201"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
            <dbReference type="ChEBI" id="CHEBI:62614"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:31168"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43676"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83582"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:43677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43672"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83581"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:43673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:43680"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:43681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:16107"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:20726"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:136757"/>
            <dbReference type="ChEBI" id="CHEBI:136758"/>
            <dbReference type="EC" id="1.1.1.211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:52657"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="35">Heterotetramer of 2 alpha/HADHA and 2 beta/HADHB subunits; forms the mitochondrial trifunctional enzyme. Also purified as higher order heterooligomers including a 4 alpha/HADHA and 4 beta/HADHB heterooligomer which physiological significance remains unclear. The mitochondrial trifunctional enzyme interacts with MTLN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="42">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="45">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.211" evidence="36"/>
    <dbReference type="EC" id="4.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000802">
        <property type="protein sequence ID" value="OXU26435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6Y9"/>
    <dbReference type="STRING" id="543379.A0A232F6Y9"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016507">
        <property type="term" value="C:mitochondrial fatty acid beta-oxidation multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000011">
        <property type="entry name" value="Fatty acid oxidation complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000002">
        <property type="entry name" value="Trifunctional enzyme subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012803">
        <property type="entry name" value="Fa_ox_alpha_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050136">
        <property type="entry name" value="FA_oxidation_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02441">
        <property type="entry name" value="fa_ox_alpha_mit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43612:SF3">
        <property type="entry name" value="TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="46" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="44">
        <location>
            <begin position="365"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="43">
        <location>
            <begin position="546"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="43">
        <location>
            <begin position="677"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="active site" description="For hydroxyacyl-coenzyme A dehydrogenase activity" evidence="40">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="site" description="Important for long-chain enoyl-CoA hydratase activity" evidence="41">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Important for long-chain enoyl-CoA hydratase activity" evidence="41">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Important for hydroxyacyl-coenzyme A dehydrogenase activity" evidence="41">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00035854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00050446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00051215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00051877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00052224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00052711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00052834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00052860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00052945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00052989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00062153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00066806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00068347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00077617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00083277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="PIRSR" id="PIRSR612803-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="PIRSR" id="PIRSR612803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="EMBL" id="OXU26435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="765" mass="83000" checksum="4A3E2BEECE15617A" modified="2017-10-25" version="1">MASCRLFGALTRFSRTNVNFVTRAALYQPLRTLATEAKNKHFSYKVVDDVAVISIDSPGVKVNTLNEEVMQEISTILRDVESNPAVRSAVLISGKPNCFIAGADISMLQKAKDEQTVYKISKDGHEILNKIAESKKPIVAAIQGSCLGGGLEVAMACHYRIAVKDDKTGLGLPEVMLGLLPGGGGTQRLPKLVSLPNALDMPLTGRTVKADKAKKFGLVDLLVNRLGPGVATAEENTKQYLEETAVKVAKDIANGKLKIDRSPKNLVEKLTNQIMGIEFVKDQIFKKAKAQVMKQTNGLYPAPLKILEVIRTGLDKGPQVGYEAEAKGFAELAMTPQSKGLISLFFGQTECKKNRFGAPKTPAKTVAVVGAGLMGAGIAHVSIDRGYNVILKDTNDAGLSRGVAQIQTGLNNAVKRKRINSIEKGRLLANLTPTLSYDQFRNADIVIEAVFEDLGIKHKVIKEIESRTPEHCIVATNTSAIPITKIAAGSGRPDKLIGMHYFSPVDKMQLLEIITHKGTSEETIKSAVDVGLKQGKVVITVGDGPGFYTTRILSAMATEGVRLMQEGVDPIDLDQLTKKFGFPVGAATLSDEVGIDVGSHIGVDLVKALGDRFRGGNENILVEMVKAGYLGRKSGKGIFVYETGSKHRDINPGALDILKKYSLQPLGSTSDEDRQLRMVSRFVNEAVLCLQEKILANPLEGDIGAVFGLGFPPFTGGPFRWIDYYGAHKLVNKMEEFMAHYGEPFKPCDLLYDMAKNPQKKFHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7G0</accession>
    <name>A0A232F7G0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_007161</name>
        <name evidence="17" type="ORF">TSAR_013423</name>
        <name evidence="15" type="ORF">TSAR_013662</name>
        <name evidence="16" type="ORF">TSAR_016464</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003848">
        <property type="protein sequence ID" value="OXU18770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01002717">
        <property type="protein sequence ID" value="OXU20699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01000810">
        <property type="protein sequence ID" value="OXU26389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NNAY01000238">
        <property type="protein sequence ID" value="OXU29799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7G0"/>
    <dbReference type="SMR" id="A0A232F7G0"/>
    <dbReference type="STRING" id="543379.A0A232F7G0"/>
    <dbReference type="OrthoDB" id="7678123at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU18770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU20699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU26389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU29799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11381" checksum="DF3EB26393BD208C" modified="2017-10-25" version="1">MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7K9</accession>
    <name>A0A232F7K9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000832">
        <property type="protein sequence ID" value="OXU26277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7K9"/>
    <dbReference type="STRING" id="543379.A0A232F7K9"/>
    <dbReference type="OrthoDB" id="7699782at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="18334" checksum="2BD10963EA592379" modified="2017-10-25" version="1">MSELGGYTDSENVNRLFVALKDDARKAVDTLLATTRNPATIMKTLELHYGNKCVIAKKILNDLKEMPSIDSGKIKLLQFATKIKNAVTALKSLNLTGHLESSDLIQSITKKFPAALKYAYNEYAANVPEEQAGLEKVPNFLCWQAELSANGIFEDDVCEVTQNHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7V9</accession>
    <name>A0A232F7V9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_014460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000782">
        <property type="protein sequence ID" value="OXU26539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7V9"/>
    <dbReference type="SMR" id="A0A232F7V9"/>
    <dbReference type="STRING" id="543379.A0A232F7V9"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="208"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="428" mass="47747" checksum="31C13B43882123A4" modified="2017-10-25" version="1">MTTLEDKSIWEDGEETLREEVLRMSTDEIVSRTRLLDNEIKIMKSEVMRISHELQAQNDKIKENTEKIKVNKTLPYLVSNVIELLDVDPQDMGEEDGAVVDLDAQRKGKCAVIKTSTRQTYFLPVIGLVDAESLKPGDLVGVNKDSYLVLETLPAEYDARVKAMEVDERPTEQYSDIGGLDKQIQELIEAVVLPMTHKEKFENLGIQPPKGVLLYGPPGTGKTLLARACAAQTKSTFLKLAGPQLVQMFIGDGAKLVRDAFSLAKEKAPAIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFSSTADIKVIAATNRVDILDPALLRSGRLDRKIEFPHPNEEARARIMQIHSRKMNMSPDVNFEELARSTDDFNGAQCKAVCVEAGMIALRRNATAVTHEDLMEAINEVQAKKKANLNYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8A4</accession>
    <name>A0A232F8A4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_014458</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000782">
        <property type="protein sequence ID" value="OXU26537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8A4"/>
    <dbReference type="STRING" id="543379.A0A232F8A4"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF12">
        <property type="entry name" value="RB-ASSOCIATED KRAB ZINC FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="16">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU26537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="88375" checksum="718E1A8B23F54488" modified="2017-10-25" version="1">MTADGEKDMSHCLLCNSRVGVSTRNSIGIFGENATTNLDKPIINILSSALKTTINKENAHSTIICKKCYKLINEADELESKLAEVRQEICNLYEKTSANFDEANSNGEDYTDHDYLDNVESVETVPILKSVSKESKRKTKKVTIADVPTKIEPTEIDSEKSIQIDDTIIEKLEIPKEGDHEDSINNDDIHSNMDTNSLDDESQIEEVIIEKLDSPKKQKPKKDELPDELTTRVEDNYLCNLCEGDDNNESKDAKAIIAHMKEQHDLRLYICDICGDQFRKRTDLSHHLDDHVAKEEGDFQCEVCNRIFNNLRLFRIHKRIHYPQAKSWSCETCGKRYSSKNLLEEHTNTHTGNRPYICEVCGKDFASKYTHRAHVKTHEVRPRPFECTQCSKTFLSQQNLTQHVKTHNGVKEHVCHQCGKAFGSAHNLEVHNIVHTGYKPYICRVCGKAFARKAEIRDHERTHTGEKPYQCEFCGATFSQRSNLQSHKRATHYNDKRYKCDECGKGFKRRRLLDYHIKAAHTGERPYKCETCTATFVYPEHFKKHMRIHTGEKPYLCEVCGKAFNSRDNRNAHRFIHSDKKPYECLVCGMGFMRKPLLYTHMQTQGHLNDTIVVNQPRLTTEDDVIIQDNRVHLVMDDGSTQLSDNAQLIVAELKDHVIIQGGDQQNVLSLANSNMSTEEIDQFVVDGQVAFEDASQIQCKAEVADNMEEVYGYQDAEGNTIVLPPGADIKDIVGEDESKTMRLVQIRLPSGTDGKNWLSLVQEAEEEEEEQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8G7</accession>
    <name>A0A232F8G7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000741">
        <property type="protein sequence ID" value="OXU26743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8G7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6520" checksum="AACEC34A7DC0C874" modified="2017-10-25" version="1" fragment="single">RRRKRLTSVARTESPVSCHLIAILGCGGVDQINSCVARKLDIHTGFLRASTHTHTHTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8T3</accession>
    <name>A0A232F8T3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000743">
        <property type="protein sequence ID" value="OXU26727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8T3"/>
    <dbReference type="STRING" id="543379.A0A232F8T3"/>
    <dbReference type="OrthoDB" id="7677333at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39951">
        <property type="entry name" value="FI22632P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39951:SF2">
        <property type="entry name" value="IP05660P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167136" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="83" mass="9264" checksum="2F4D9693B9B4BFE9" modified="2017-10-25" version="1">MSVTVNFLLVSYLLVWSGASAGPLWNLVHDLVQWNIAGIPTIHEKSTWNFDPDSGKQKRALYEQQNGRFGETAIARLGLGYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9X5</accession>
    <name>A0A232F9X5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tumor protein D52</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000639">
        <property type="protein sequence ID" value="OXU27249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9X5"/>
    <dbReference type="STRING" id="543379.A0A232F9X5"/>
    <dbReference type="OrthoDB" id="10000687at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF14">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40450" checksum="3B854571B4FD88A0" modified="2017-10-25" version="1">MNPELLGFGCELASFWLLRKAPFGPAISLGFTAYEMIHHLSMMNPQAYQDEKNFYYMGDNNNNRPVNEKTDASSTTSAATDEEFVGPEFEEDAYYSSLAPTPSFDDLDDVSDSEEILVHWHQEAGEIEEIEEADFREEREGDQKGTRREFRLLKAKIREKSRRLLGLVKGEDAALHRSGSLSPSLDNVASELQGMTVEEQERQKAEWSAELAKIEDEIQTLREVLSSKVRMAHELKRKLGISVWKELSVDVNQGLKNVKESQVYQKTESVLKNTAEKTTSILGGFGSGLSMKIGQMRNSDSFRSLEEKVGSAYENVKGRVTPSRSNSTQSFDEALREAGASRRASAAPSATSPTIPEDKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAE6</accession>
    <name>A0A232FAE6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000566">
        <property type="protein sequence ID" value="OXU27635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAE6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="131" mass="14493" checksum="E477FEEBB1C07201" modified="2017-10-25" version="1" fragment="single">TTLESSFDVLNAEWFEHLELMDVSAPPPSSGYRALLKRPPYHSGAISRSKYAQPEPRRISFFLSTKRKQTLSKLPGRLRPRIIASDMLEIPLLLPPGRTAAHAPPSPVSLAEKKAFPEPLATSVVDLTTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAG7</accession>
    <name>A0A232FAG7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000571">
        <property type="protein sequence ID" value="OXU27612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAG7"/>
    <dbReference type="STRING" id="543379.A0A232FAG7"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="5">
        <location>
            <begin position="263"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 N-terminal" evidence="2">
        <location>
            <begin position="472"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="4">
        <location>
            <begin position="1163"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1209" mass="140109" checksum="0B4EEAE8636DED29" modified="2017-10-25" version="1">MVRHNNQLPDNLPQLQNLIKRDPESYREEFLQQYRHYKSTLEVFAFTPDKFNKSLDELVMFLAQVLGEEIKCRDSLIRTLYSLLRDDPMFQSLFIYGHVSCGKSLIVQSVLKYLDYNVSIINCVEHTNNRSLFEKIIVDLTSIKLSSSNGYKLERRCDDFVELIFQIKSIAKTNPKPIVIVFERCDKLRDLHANILPGLVRLGELTQSNVCTIFTSDVIWEKYKPKTGMYEPITLHFPAYNKDETLEILLHTTKPMEYETTFYRTYLNLFLSVFYRFCRDLHELRYMAKKNFLKYIEPLENGLIAENDTNSLWRNISHTLRENLEVIYLRVSTDDFEQQNKLSRELESTARLALSFELPFYAKYLLIAAFLASYNPMKEDRRLFMKEAGPKKKRVSKRKNEKLVTNIREGPKNFPLNRMLAIFCSIINEKIDMNAVLLTQISSMCRLGLLTVVGDNNIDEPKYKCCINYEFAMVAHCYTEDLTTFPQELIDILKGKNTVLDSEMRMTFCRALILLRNKNLLEPTALLSLFFELLRCQDKALRQFLETHIITDIKNVNAKHKNAKVNTVLQNFMFKMLKDTNARAAKMSVDIMIELYNKNVWNDAKTVNVIATGCFSKFTKVMVASLKFFLGTDPEEESDDSSSDDEPTMKEVMMANKVNKKTKKREKQLKKAKQLFVKSKKKKSKAPQFNFSALHLIHDPQGLAEKLFKQLEKNNDRFEVKVMTLDVISRLIGLHNLFLFNFYPYIQRFLQPHQREVTKLLQFVAQASHELVPPEIIQPVLKTLVNNFVTERNSADVMAIGLNAVREVCSRCPLSMNEDLLQDLAQYKNYRERSVMMAARSLIGLFRQTMPDLLHKKDRGRPTEASVALEPLKYGEVAATEYVAGAEVLLESKKDTLEIDSENSDDDDEWIDVQHSSDEGGEVGEGEWETDDEENEEDGSDDDEEGDEDEDEGSEVDDDDSGSEEDDEDEGSDEENEEDSGAKKKTMNGDKKDKIKEKKVKKEKGDAKKKEGEDKLNTSDGKPSVKVSALKKKNKRSKLDRKKRKLQEKLKLQEKLKAQKKTEYTAEKKAKASQVSAERLLTDEDFKRIDMALVKQQVTHAKRGVKRSADEDKGKGELVRLTDIENIYKKRKHDKQARLETVQKGQEGREKFGYKDGRQNPLCSKTNRERNKKKNFQMIKHKVKGKIKRSFKDKQVALRNHLVKLKRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAV4</accession>
    <name>A0A232FAV4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000542">
        <property type="protein sequence ID" value="OXU27785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAV4"/>
    <dbReference type="STRING" id="543379.A0A232FAV4"/>
    <dbReference type="OrthoDB" id="8193571at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="591"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="962" mass="111144" checksum="D5C760312A495DF1" modified="2017-10-25" version="1">MVRRATCYEALSLAIRKNSVKYTKYILRRSNGLVIDNNWTDYLLLIKTLQRGHRKIVKLLLKENCRVNKTENTNFFHTPLYYATRLGDVDLVRMLLSKGALINGRDFNKDTSLCLALKMKYYKIVDIMLSHYLNQVLEIYVSSQNSDDTIAFSAACLRNKERVVEEFIRRGMTVNIHLDSGLQNASNCTPLHIVVKHQNLEVIHVLLKNGANFTAKNGLGQTPLHLAYYMREKCYPYKDCCKIIDILLAAFESRATPNPLTEDNLGLSSFHIACTRDQIDIIKYFLHQGVDVNKSVYFDSPTCAGYTPLHFAIENRHKNVVELLLEHGASTIMKNMSGQTPFHLAFSFFYSDHDFLDSILNKYVPKNVNPINNFGLSHLHIACTTRNTNAIESFLENHADAINKRVNFDASKCPGYTPLHFAVDFNRKEAVEILLQHNVDINLKDKDGFTPLHLACQQNAKKIHTILRNSLSPIMFEIINSDHSLFFFKESPSITTKHKVIDLDLIDKQTMQVEIVDLLLRHKSDLDSQDEFGKTPLFYACDIDHETFECVFGKNMTQYLHKILNLFYIKRSQILEILLRYKPHVNIYDNNGKTVLHYVADIDKPFGDDKKAEVATVLLDNGADVNARNKTGLTPLHIALKKGYVDLVEVLLKYNVDPNIAEYENFCTALHLATFNDFLAPKSEEIVSALISKGADVDRRQLDGKTSLHIAASTRFSTSRLIPLLEVDCDIDCQDSKGKTALHMACLNRNPDNVQNLLRHGADFNITDRYGRTAFFYFYEYQIEVLECRRTIYNFHQIYYIFKDHIRRLKSIDFYVSWENMSYYMKLKDLHRQQQVNNVENEILLKCEYEIKKMKSIKLNSYSTLYDILFKDPNEMALYVENENFKNIVQASNFKSEFPQYRYLLELQLRKGKTRSELLNPAKEALEFILGISLPDACSEMIFRYLCNRNLKDLIKAQNSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBQ3</accession>
    <name>A0A232FBQ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 12 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_015550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat DCAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000518">
        <property type="protein sequence ID" value="OXU27898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBQ3"/>
    <dbReference type="STRING" id="543379.A0A232FBQ3"/>
    <dbReference type="OrthoDB" id="9610195at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001037">
        <property type="entry name" value="Blast:DDB1-and CUL4-associated factor 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF16">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="11">
        <location>
            <begin position="102"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="11">
        <location>
            <begin position="306"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU27898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="495" mass="56261" checksum="688A25417274F810" modified="2017-10-25" version="1">MAETQRMTTYGRYPSCAYSSRLEERRSRRVAMIIDRNRKSDKPDDFVCYESSDDEEEPAMDGKQFLRTSFSFVDYVRSRETNTREIRKINREFGSRHILSHDLFKEYSVSLNNMNKVFCSQWLSDRQVVFGTKCNKLMVYDVTTQKLDQIPSLHGRQNASAGTGNNMETQFGIYSVQINPSRTLLATGGRNSTEIAIYRLPTLDPVCVGEQGHRDWVYDMCWLDDEFLVSGSKDSKMALWQIDSDLSEAPDKADIPSHRQISNNEKKFISTSKQPLKINCNEEKKSSKDRPICLGLIQPVCMKECRSAQKVRSLLFNKAYKEIAVLSMNSFIHIWSAETFKQKLSRKLPACQDNVCLAVHDDGLYAVGCRSYTLLLDARTLQPIKKVPSRYSGCGIRSASFQGSVLTVGTGLGMLMFYDIRAQKYLESSINSNRTVMLKASKGYVFPDEEYVDGQNVKYTPAIYTHCYDASGTRLFCAGGPLPTNLYGNYAGLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC31</accession>
    <name>A0A232FC31_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spliceosome-associated protein CWC27 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_006422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000441">
        <property type="protein sequence ID" value="OXU28371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC31"/>
    <dbReference type="STRING" id="543379.A0A232FC31"/>
    <dbReference type="OrthoDB" id="6435218at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000007">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CWC27 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="APD1-4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="APD1-4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077">
        <property type="entry name" value="DUF4793 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-4 MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="APD1-4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="APD1-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1196"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1215" mass="138625" checksum="22716D249FD29B3C" modified="2017-10-25" version="1">MSNIYIQEPPTSGKVVMKTSIGDIDLELWTKEAPKACRNFIQLCMEGYYDNTIFHRVVKGFIVQGGDPTGTGEGGESIYGAPFKDEFHTRLRFCRRGLLAMANAGKDDNGSQFFFTLAATPELQNKHTIFGKVGGETIYNMIKLEDALVDENDRPVYPVKVLKTEVLNNPFTDIVPRTVPKKLTDEEKVKKKDKKGVKDFKLLSFGEEAEEDEEESVVISKKLGTKSKSAHDILSDPKLSSQPVIEEDPSKKSESDSENDDDDPRTAEERAAAQKEKQEMTERIKSKLKASTAKIANDPKVSDKEDESSEEEYYLGKERKEELKKLTQAKKKEIRDFKRGMKNEENKKLEKEKQKAEEIKKKEVKSELVLEHNVTKKKYKEEFSKLPRKGAPREDFTSQKMKQFMSKINQIKNVDPGEEESVSSQVVKAKDDDDDDLTDDSWMKTALHSEDSAPVLAKDASTKGDDWFEIYDPRNPLNKRRRGETTDKRALGVLLYYSLRRHARHLHANTVSYYCRELVEQRVECESQQFCARAPKVRVAVTCCSLPEFDTWTWSFVNQRDELFGCTHKEYPHYRGDNNMKEEDCESGVAAMSKMPLRLDSFIDEGLRPRDWQPRPTQCKVPLRLVRLCFLGVLLPAMFVAGPIYLRYRVFSEQLYPLAISDQRLIDGRISTTWCQRQVVKANATFNAYLMNGVPKIQGKATPVTMTRHLVLEDDMKEYWGFYLLRGSSVTVSTCVRWPGASLTMIRGHKHLHECAFIGDDSSEELEELVEVAQERGLLQRPNETNPNSPSNEPSRMKRVHQGVQLHNTNETSYQHHLQHNQQLTSHELDAKDMRAILTQIFMKQLDMKKRQKDANEPSQHHHYEGVFRESDNIVKPPTFDDTEFIKHELLSLRAQASEASVTLEDMGVTSSATVSTTTESTTKTPEVKTTTAESLIAEMSSTLGPSSMEVFEDALHKISALGTRGKKVLNKLIQEINHRDPETEQMVKKVINEVTEKEERRRKRDLLLSSPMGAQLSEDDEDGDAAIEEGMLHPDGIAEDRGTVNETTLNDRSNSEFWSSFSSSEERLLECKGLILNLPLTPHRYCEAKWEHRHSSASIANAVTYRVPTDGYYFFVFSSENEIQPNYLRVKFELLKTMYNTSDPVFQCKNSTGECSLPISFFSSERTVLELPVNGNNSQWNDEYVVISTCEPRTAVYLVCTMAVPLLILMFAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCF3</accession>
    <name>A0A232FCF3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000450">
        <property type="protein sequence ID" value="OXU28302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCF3"/>
    <dbReference type="OrthoDB" id="6608749at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="189" mass="20723" checksum="6129AF352765C94D" modified="2017-10-25" version="1">MRSTAAVPPKVLPIASRNMGLSEIPEQMSYYPTLTREEKARMHPCKKAKCVMMSADSSPTLQASLPSPNYVDLPDEPRPGKITPTTPATNTTNSSPSPRASKSDDTGGKSSPEVDEEEAIEEAVPIVRTTLPSPEPRPLIERNGYKDHDRVDGINGIKQKPPQQHDVDDDSCLIKCVYFTQQCCECTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCG8</accession>
    <name>A0A232FCG8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="12">6.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GTP-specific succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="12">G-SCS</shortName>
            <shortName evidence="12">GTPSCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Succinyl-CoA synthetase beta-G chain</fullName>
            <shortName evidence="12">SCS-betaG</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_003631</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.4" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01000465">
        <property type="protein sequence ID" value="OXU28180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCG8"/>
    <dbReference type="STRING" id="543379.A0A232FCG8"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03221">
        <property type="entry name" value="Succ_CoA_betaG_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034722">
        <property type="entry name" value="Succ_CoA_betaG_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="15">
        <location>
            <begin position="32"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="14">
        <location>
            <begin position="300"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="359"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="12">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="12">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="441" mass="48140" checksum="34A631ACAD8E4EEC" modified="2017-10-25" version="1">MSSFLVRKSLVGSVKTLKSLSQFGIVPVRRLNLLEYQSKELLRDSGVSVQNFAIVDDLQKTPNALETLHAQEYVVKAQVLAGGRGKGWFDNGFKGGVKITKDKKAVAEYVKSMLGHRLITKQTSKDGILVQKIMIAESVDITRETYVCILMDRSHNGPVLIASPAGGMDIEAVAEKTPEQIKTIPLDIYTGIDDEIAKEVAEFLGFKGEKLEQKAIYELKNLWKLFVDIDALQVEINPLVETKDGEVVAVDAKISFDDNAEFRQKDIFALEDTSEKDPREVDASKFNLNYIGMDGNIGCLVNGAGLAMATMDIIKLNGGTPANFLDVGGSVKEDQVYQAFRILTEDPKVQSILVNVFGGIVNCATIAKGIVSAARNLGLKIPLVVRLEGTNVNEAKKIIAESGLPILTANDLDEAARKAVASIKKLQSEEGHNDMKLKMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCL4</accession>
    <name>A0A232FCL4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000416">
        <property type="protein sequence ID" value="OXU28554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCL4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="13620" checksum="7666F8E05CC72050" modified="2017-10-25" version="1">MEKSFLCPQRHVIPHGAKVFVTAFLLASHLTPRKPEKKCKPNDEKIPNDRGLMEHCWKLVPYKYNLSPDPPTSSLELLMMQSRREYEKVHPPKIPEPELNGKIHYDYGKIFKRIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCW5</accession>
    <name>A0A232FCW5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000428">
        <property type="protein sequence ID" value="OXU28472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCW5"/>
    <dbReference type="STRING" id="543379.A0A232FCW5"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="60"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="413"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="63688" checksum="3B639F70806740C5" modified="2017-10-25" version="1">MFAPIDDHDDPRCSTADEELDDIPNPRARLNQMAQHNQMTQHNQMAQLNQAVRFDAMERKRQEYIKELIVTEEAYIVDMQLVHEVFEKPLLASMVLTVDEVEKIFINWRDIIACNDNFLRTLRIRRDNSESGIVRMIGDILCESIPRMSAYVRFCSCQITAAVYLQRLTESMPAFVEVAQRCQQDPRTKGMPLSSFLIKPMQRITKYPLIIGKILEYTHPGHPDRQYLQEALAKAEEFCTQVNEGVREKENSDRLEWLQSHVACDGLEEQIVFNSLTNSLGPRKLIHFGILHKAKSGKELVGFLTNDFLLFAQPMKSIPSGQQFSFERNEHQKFKLYRRPIFLQALVLFNETEMNGSMSATSNGGSDSSTEHSRTLKLSDSKKAITLLAPSVSECSLWVRRITEARRQFAENEKCRLLRQRSIRRRPPKGLLRIVVEEAEDLVSINKGKCNAFCKVSMGSQEEQTIVVSGTDCPLWNTSMQFQVKDLHEDTLCITIFDKGYFSPDEFLGRAEVRVVDIVRDSTDACGPITKRIRLREVDRGDVVLKLDLRLFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDF5</accession>
    <name>A0A232FDF5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_016821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000371">
        <property type="protein sequence ID" value="OXU28826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDF5"/>
    <dbReference type="STRING" id="543379.A0A232FDF5"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015173">
        <property type="term" value="F:aromatic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015180">
        <property type="term" value="F:L-alanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904273">
        <property type="term" value="P:L-alanine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903801">
        <property type="term" value="P:L-leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015823">
        <property type="term" value="P:phenylalanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11329">
        <property type="entry name" value="AmyAc_maltase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042280">
        <property type="entry name" value="SLC3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031984">
        <property type="entry name" value="SLC3A2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46673:SF1">
        <property type="entry name" value="4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16028">
        <property type="entry name" value="SLC3A2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="182"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="640" mass="71335" checksum="6E782D7C3BD7136E" modified="2017-10-25" version="1">MEPKSGSKLDSDSAAEAATANTGNGSVAPTDLVQPTYKQLPDEDVNWQARNNAEEKKEPPNKAAMGKQNGTDPEHDDGAQERMLKDDVKLSVVPSKDASEVKFIPENGDAKIDIETVKQSLSGMGKAELMKYANDPFWIRLRWFLFVAFWVLWAAMLAGAIAIIVMAPKCSPPPPKKWWEESPIVRLDPSDSATKDLSGLEFYLDILKKQHVKAISLSSIIKETAPGHTEDYKDLSQKVGLFSDFTKFVGKAKANDQNIILELDPNHSSDQHPWFLKSVKKEEPYTSYYVWADGKVDPESRTLLPPNNWVSLNGGSAWKFNEERQQFYLHQFNESQPDLNYTNPAVVNEFSDILKHWLKLSVKGFRLANTRYLVEDPSLANDSHSSSYPAESGTYQSLLHIHTRDHPQNAVVLRKWRDVVSNYTNGDGLFALSDDTGPDVLQMYNQQKTLVDLPQSINFLANIDPTVTAAALNQSISTVLAFASWPGIDFNGKETSLRKRIHAEIADSLTLMTMLLPATPILKLNDTISAKDAFATLAETRKSKPFLYGDTKTYVLNNGTVFVYTRIKSGTPGYLVAYNSASQNTTMDLTSVKYVPEEVSVYARSPNYVENLDVLKKVISNNVPISPKSTLVVTFAPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDH7</accession>
    <name>A0A232FDH7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000366">
        <property type="protein sequence ID" value="OXU28854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDH7"/>
    <dbReference type="STRING" id="543379.A0A232FDH7"/>
    <dbReference type="OrthoDB" id="6260541at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9329" checksum="8C5E53ADBF46142D" modified="2017-10-25" version="1">MRRRRQQKLERKLQQFRSKDGGPDTGGTLKIYGEALCKDVPYKTLLLSIRDSAAQVVREMLAKYGLEKVDPQQYCLVQVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDZ3</accession>
    <name>A0A232FDZ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000388">
        <property type="protein sequence ID" value="OXU28740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDZ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49365" checksum="FC81BD1B6C696E5F" modified="2017-10-25" version="1">MYGNTAGWADAFSNSASLPFHQTGNAIPEFEGKAAENFGAHIANYTSVEKLLHDITLHYAKIGIADQIYTQMRSIKQGPNKPVGECGLRVEKLFNRFMTIVESASDLSNSDRFLKDLSAAITTAIEFEGKQNSQDTGNAPLLTKLAAQVRIATAEEVVVSGEQKNASAGSNNNKNAKNAKGENKNGNGNNNGNDNGNKSNQKKDKNWNNKNRRDSSAESRKRDSDRDNKNNSDRQPPILSVNCPQLRKRTGKFFADSGADISVVKVGELAPCYPYDTPKNIKVQDVTHGTAVHVVSSNFPIENSGIIGWDLIHAHKGCVDADNKCPQLGDIKLPFEFAELVKIPARVKMVIGARVRNDDVNVKWVPLQNLHPNLLFSKFTDENINGRVYAECINISDTEVTIDTPTVELEEVETAITNSPPADEDGGADSDANSSAKIRRVINSDKHVEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEA0</accession>
    <name>A0A232FEA0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000369">
        <property type="protein sequence ID" value="OXU28840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEA0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10598" checksum="44783B7292BA7CFB" modified="2017-10-25" version="1">MWGMQMIERTMDSNKMNLKIIIHKIIIEAITIEEEGNKIIMATKVDKQVTIVTTIIGSNNVTIARLGIAMETAEISKYSIANSRKMDVDENSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFK4</accession>
    <name>A0A232FFK4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein LMBR1L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000287">
        <property type="protein sequence ID" value="OXU29475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFK4"/>
    <dbReference type="STRING" id="543379.A0A232FFK4"/>
    <dbReference type="OrthoDB" id="5596951at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008075">
        <property type="entry name" value="LIMR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625">
        <property type="entry name" value="LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625:SF0">
        <property type="entry name" value="PROTEIN LILIPOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01692">
        <property type="entry name" value="LIPOCALINIMR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57745" checksum="C4904D7D8F425D40" modified="2017-10-25" version="1">MKIQLSEHSKIFFIKAVSRLLPDCIIKILIFALNFQIFLLLFLILYISSYALISRFRWRGGEDYLDTDEDEATVYRISLWLCASALAVSIGAALLLPVSIASNEVLILYPNSYYVKWLNSSLIQGLWNLVFLFSNMSLFVFLPFAYLFTESEGFVGYRKGVMARVYETVTVLCLLGAMVLGMTYILSAVLDRQKSSLHTLLICTPVGFVRLFGVVGSFLVKPQFLKNLDEEFFAYRLEEDCIKRRLENAKATGKSYVSPVPMSPAASSYQAASEEPLCPSPSLMCLRNGALQRGLAQRLEDIQRRRHTLDEQRRTWWVRRTLLYPSSMLALLLFSVVTAFLAVQNTLQLLVGIKALPLSTRQFTLGISSLSKLGPIGATIEVAVILYLAVTSAVGLYTLPGVRLVRPRLHSTPLTHLIANCALLLILSSALPLLSRILGMTNFDLLGDFGQIEWLGSFRLVLLYNVIFAAAAIGCLATKFTATVRKEIYARLRSSLLGIFRRKRIVVAAATLSSKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFS5</accession>
    <name>A0A232FFS5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000277">
        <property type="protein sequence ID" value="OXU29545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFS5"/>
    <dbReference type="STRING" id="543379.A0A232FFS5"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048407">
        <property type="entry name" value="Dumpy_DPY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21164">
        <property type="entry name" value="Dumpy_DPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90148">
        <property type="entry name" value="DPY module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9152" checksum="1BDA8CF1D1AD2A07" modified="2017-10-25" version="1">MPLGNPFSDCERRVVETADEPECRKDSDCAFRLACIKERCQDPCPAIRPCLEGARYSVLDALPQFNCTIKMLIPTQFLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG33</accession>
    <name>A0A232FG33_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_007749</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="NNAY01000281">
        <property type="protein sequence ID" value="OXU29523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG33"/>
    <dbReference type="STRING" id="543379.A0A232FG33"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14294">
        <property type="entry name" value="UBA1_UBP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000026">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="162"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="317"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="673"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU29523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="797" mass="90173" checksum="421EA7877DD242FE" modified="2017-10-25" version="1">MEELTKHLEKVKIPTPNDKIYKDECVLSFDTPETPTGLYLSLTTFLGFGVDYVSDYFQRTGNSVFLHITRIKHEIPAEETEGGPDKKITRLAIGTQGGFNPDVQKYKYEEKYEIVLMPGFVRIPYPNEDLPKPVNISIEAVLQAESALKIAEKEALAGTWDGEARVITRHLHLTQLNNNKKVPPIGWKCERCDLTTNLWLNLTDGAILCGRKFYDGTGGNDHAVEHFRNTGYPLAVKLGTIARDGKADVYSYDEDDMVEDPNLAVHLAHWGINLAHMEKTDKSMVELELELNQKFGDWIAMQEGNNKLTPMYGPGYTGLVNLGNSCYMNSVMQMSFTIPDFVDRFVSKANEIFNQNLNDPPNDFNTQMAKLGVGLLSGKYSQQPESKTDDENRQGIPPRMFKNLIGRGHPGFSSNRQQDAQEFILHLINILDRNSRHQTNPADCFKFKVEERYQCSSGKVKYTHRPEYLLPIPIPMDMVINKEEVAAYEKNKTDEDKAKFDPNLIVRPRVKLSSCLESFAKTEIVEQFYSSALNDKTTATKTTRLASFPDYLLLHLKKFTVKEDWTPIKLDVAVEMPDLLDLNFLRGNGLQPTEELLPESNTTPPIVYDQVLLGQLADMGFPVEACKRSLYFTENRGLDSATQWLMEHISDADFSDPFVPPGVDAKSDSAAFVPNKESLEMVMSMGFTKEQATKALKATNNNLERAADWVFSHSSELDTLDMDVDAQPPEPSFRDGSGKYKLVGFVTHMGTSTMVGHYVCHLLKDGQWVIFNDEKVYSSEKPLKELGYIYLYQRLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGL3</accession>
    <name>A0A232FGL3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000287">
        <property type="protein sequence ID" value="OXU29467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGL3"/>
    <dbReference type="OrthoDB" id="10605894at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="357" mass="40959" checksum="83BB009811E41618" modified="2017-10-25" version="1">MSKLLELMERLNKEEELQLADMQNRFAEQDRKYEELKKTLDFYKDETHKHTDSFMKSLDKLVSNKHTIEKALKRTENLTGLSVPQEQHSTVVDLVAKMANFVGNINNVIDAPNNTCPDDIHEDVVNIMERTENDLKVCRTEVTEIQDLLYNTKSLNRLLNDANVRGCCVVKHYSVIEKMSENMSDLLKTMDTDEELHQQEDQNYFAEQDKKFKELQMKLTRLKEENKKQMDIIINSLDQLILNKSVVEKVLEQAGDGYDSAPIVPPAEANNLTVAELLSKVTGFLNNMDVNTSNKTLSNELQEKVLTEGTAQDSKKNSTDKEEKKDEKSVPQEKRKENIKSNPKKDYADGQKNSDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGX9</accession>
    <name>A0A232FGX9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000218">
        <property type="protein sequence ID" value="OXU29945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGX9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012104653" evidence="2">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="351" mass="39981" checksum="166AA1F159CFACC4" modified="2017-10-25" version="1">MCVCVHEPSAVRMKRFLILLVFCLASPLGRADIYDDTVTCLKERGLKETDIRILDAVGEPGNEHILKDAPKDKLVDAIACIFRKDHKTNKALFGTLTELINMDSEIDNNKRKELLVTLNACNKKSDLRYRKMLHRESVSEVLKHVGEDNITCAMTCEFDKNKHVYKDMDPNETIHKRLETLITKSKFAVDFYKEKIVNLNRSRRQPTGGEEEGNEGDPGPMRPPRPVETFFIFQVDTATFEEVVKTNGDALKNVDKQVACVIACAFDDFTQKKESIYNYLTRIIKKDLDDEYSASERKEMLDILNYCNGLAFGNDCKFLHCINVTKAPFADLILTVGIEDSGKGEDQKMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHD6</accession>
    <name>A0A232FHD6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_004181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM147 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000195">
        <property type="protein sequence ID" value="OXU30092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHD6"/>
    <dbReference type="STRING" id="543379.A0A232FHD6"/>
    <dbReference type="OrthoDB" id="9993532at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU30092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="249" mass="27826" checksum="F5505D3BD786EE9B" modified="2017-10-25" version="1">MTLYHFGNCLALVYVPYYLTYKYSGLSEYGAFWKCIQAGGIYVFTQLVKMLVLATFFPAADNIGYKGFDFFGVRELNLFRKKLDVGYGSNNLEFLKSSIDLADLVGIYLVLNGIPGKGHAKVLTAGIGWAGAEVVLTRFLLLWVGARGAEFDWKYIQKSLESNICLVQHITTATLVWLWSRHDLKQSLVPIVVSMLLLTVYRPLISDFLITSFTIGAWSTLFIKLITAIVMGAITLHIYAALAYSIGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHX4</accession>
    <name>A0A232FHX4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000177">
        <property type="protein sequence ID" value="OXU30285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHX4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="41" mass="4637" checksum="896494E01AABC37F" modified="2017-10-25" version="1">MYYIFEFKGITLDVPIKIMFYGSTVVMVVSCNAKIVLATET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHY5</accession>
    <name>A0A232FHY5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_015880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000169">
        <property type="protein sequence ID" value="OXU30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHY5"/>
    <dbReference type="STRING" id="543379.A0A232FHY5"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000040">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000394">
        <property type="entry name" value="Zinc finger protein 836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="473" mass="53070" checksum="602EECBBCF81294C" modified="2017-10-25" version="1">MFDPQQIQQQQAAQGQQSQQQQTQQMYVTTDKKDDKSGQQSTTTEFPFYYNVNMLQKVQANAVGTIGAITTDDKGHYRFDVQPGYNTLINQMNLATNTTFKCDICGLVFGHMSLLNHHKRIHNSTPSNLQQQPLQVVVQTPTTVTVATTPERPYTCDLCGACFALPGELKSHKTNMHAKPKVQICEECGSEDPCEHHPTKIKKIIKPGHHPVKRRGVTSVTKCHKCNGTGIIFIGGKANSHHQEKPFHCNVCDGTFSRYSSLWSHKRLHSGDKPFKCEVCGLAFAKAAYLKNHGRVHTGEKPFKCSHCGMQFSQSPHLKNHERIHSGERPYQCEVCEKTFARHSTLWNHRRIHTGEKPYRCNICGSAFNQATHLKNHAKVHTGEKPHRCDICEIGFSDRFALKRHRAIHEKYGQTAARNSQANASNVQANTSAQGQPQQVVVVNATTPVTVSQGQPVMLEEVYKCQVAFPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIS5</accession>
    <name>A0A232FIS5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000146">
        <property type="protein sequence ID" value="OXU30582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIS5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="21" mass="2545" checksum="0C51CE394D44C9F2" modified="2017-10-25" version="1">MKEIGNCLYEIYFHLQQTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIY7</accession>
    <name>A0A232FIY7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000177">
        <property type="protein sequence ID" value="OXU30267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIY7"/>
    <dbReference type="STRING" id="543379.A0A232FIY7"/>
    <dbReference type="OrthoDB" id="7700944at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20907" checksum="0B861A78F294833A" modified="2017-10-25" version="1">MKDAKRSLKKKIRKNKRRCLKELQDEVEQYPWGRPYRIVMKKIKGNYVPPPKCPSIHLVVSTLFPRKLEKPSVIERGLNKEANPPITIENLLAACRMVGNNKAPRPDGIPNIALLCMLDTSGKILERIICVRMANRDGLELASHKTEVILISNRKKIEEITLTFDGREIVSQPTIKYLGITIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK56</accession>
    <name>A0A232FK56_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="16">DHOdehase</shortName>
            <ecNumber evidence="4 16">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_012775</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="16">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Mitochondrion inner membrane</location>
            <topology evidence="1 16">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 16"/>
    <dbReference type="EMBL" id="NNAY01000129">
        <property type="protein sequence ID" value="OXU30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK56"/>
    <dbReference type="STRING" id="543379.A0A232FK56"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000066">
        <property type="entry name" value="Dihydroorotate dehydrogenase (quinone), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003645">
        <property type="entry name" value="PRK05286.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 16" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="83"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU30707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="399" mass="43251" checksum="1DF12C7ED7E58227" modified="2017-10-25" version="1">MSTMRPIENLTNLRKIKSLLGVTGGAVAIFTGVSLYQGNEKFYSNVAMPLIRLIDPEVAHRIAVKTAKLGLAPSQSTPDPPILRTSLWGLEFENPLGMAAGFDKHAEAVGGLHKMGFGFVEIGSVTPDPQPGNPKPRVFRLPEDRAIINRYGFNSEGHDVVHKRLQALKSSSDFHGIVGVNLGKNKLALEPVLDYVEGIQKFSDVADYFVVNVSSPNTPGLRNLQGKKELEELLGKVNEARDKASRRPPLLLKIAPDLAEEELKDVAEVITKSKTKVDGIVVSNTTLRRENLFNASKDEAGGLSGAPLSELSTKMIARMYQLTGGRVPIVGVGGIFDGTDAYSKIKAGASLVQIYTSFAYHGPPIVPKIKRELAELLEKDGHEKIEQAVGKEAKKLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKS2</accession>
    <name>A0A232FKS2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000093">
        <property type="protein sequence ID" value="OXU31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKS2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="186" mass="21149" checksum="40AF4C4D6B91340B" modified="2017-10-25" version="1">MRAHALEVYPVDQIPMTSVKPCGFVFDTQSHKRHDIHWVEIYVFKNKVVWYFDSFGGQSYILDNVNSIQRNLRVEEGSAGGDGNIPHAIHQSFVDRRGVNTLTKKRKGFSPKCLEKSEALRIERKGGKVLSKVSRKIRGTLYRKRKSKGALSKVQMSPWRVNNLDLDLDFLLALGGGLSCKMLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLA9</accession>
    <name>A0A232FLA9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000075">
        <property type="protein sequence ID" value="OXU31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLA9"/>
    <dbReference type="STRING" id="543379.A0A232FLA9"/>
    <dbReference type="OrthoDB" id="9983043at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615:SF2">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="309" mass="35616" checksum="945A925F83FA1E41" modified="2017-10-25" version="1">MARDLEYSYIGPYLRDWLEYVRKKNDADQQMIADGNEFRVPFVGVQTEMIQMIFLLSSRYDLEPQAKHMAVHLLDQYMARLFWEIVSNSPKLNDKAAEKQLRDKMSSQVRLVMVICLQIASKVDLYKTGLDVEQVQNILKWVDSKKEYNKSSICSCEKRILEALDWRLPICLPIDAVELFLVYADLASKPKVRDSCLRLLDVAYLRHAELFEQMHLLATGRPYDKSLRVCRNFLELETNSAFLGAAIVICSNFFFCLKRKIVDSLAARLANLIEMSAVDVSIMANVLFSFVVDEDDLKNLQSTSDNEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLS1</accession>
    <name>A0A232FLS1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLS1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="11421" checksum="79155CF0C7AA5DC7" modified="2017-10-25" version="1">MLEPRTSPSQAGWRSRRLNGVEARTHEEASDVAVMPSQRAPVTHAHEFVIVISRQIARPRRSCLSSASSNESVARVLNLAREALALSPHSPSWCAPSRCSAAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMB5</accession>
    <name>A0A232FMB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000028">
        <property type="protein sequence ID" value="OXU31812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FMB5"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003127">
        <property type="entry name" value="SoHo_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00459">
        <property type="entry name" value="Sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50831">
        <property type="entry name" value="SOHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="SoHo" evidence="7">
        <location>
            <begin position="2484"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="915"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1234"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1322"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1559"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1788"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1842"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2038"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2181"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2285"/>
            <end position="2383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2468"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2543"/>
            <end position="2615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2687"/>
            <end position="2821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2927"/>
            <end position="2998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3072"/>
            <end position="3155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3296"/>
            <end position="3369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3714"/>
            <end position="3757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3788"/>
            <end position="3815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3842"/>
            <end position="3863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="4069"/>
            <end position="4092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="4150"/>
            <end position="4250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1942"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2831"/>
            <end position="2858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="3473"/>
            <end position="3544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="915"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1234"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1257"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1273"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1565"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1797"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1863"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2039"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2116"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2304"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2352"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2481"/>
            <end position="2491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2547"/>
            <end position="2556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2729"/>
            <end position="2741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2754"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2780"/>
            <end position="2789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2807"/>
            <end position="2816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2933"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2951"/>
            <end position="2960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3103"/>
            <end position="3112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3127"/>
            <end position="3136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3143"/>
            <end position="3155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3303"/>
            <end position="3317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3324"/>
            <end position="3333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3334"/>
            <end position="3348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3718"/>
            <end position="3727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3730"/>
            <end position="3752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="3789"/>
            <end position="3799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="4163"/>
            <end position="4172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="4207"/>
            <end position="4220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="4237"/>
            <end position="4247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU31812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4285" mass="483993" checksum="4C0E99E76C9B48D1" modified="2017-10-25" version="1">[encoded data, 4285 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMS8</accession>
    <name>A0A232FMS8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Guanylate cyclase</fullName>
            <ecNumber evidence="3 12">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_004322</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 12"/>
    <dbReference type="EMBL" id="NNAY01000011">
        <property type="protein sequence ID" value="OXU32024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMS8"/>
    <dbReference type="STRING" id="543379.A0A232FMS8"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000801">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000039">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF462">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="319"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="544"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="889"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="938"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU32024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="964" mass="106677" checksum="7852FCAD0C66F374" modified="2017-10-25" version="1">MLPYGDLVQLKQLPVQGAFELKGKAMDVLVTIHGLRHENLNPLIGCLTEPSRPCIVYEYCSRGSLEDVLVQDEIKLDWSFRLSLLTDLVRGMKYLHSTPIRVHGYLTSRNCVIDARWVLKVTDYGLPAFYEAQNVQPPERTARDLLWTAPELLRHAGLQKRGSQPGDVYSFGIVMQEVVVRGEPFCMLALSPEDIIEKVKKPPPLIRPSVSKGAAPPEAINIMRQCWAENADMRPDFNAVHDLFKKLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDMEKKKTEQLLNRMLPSSVAEKLKLGMPVDPEEFAEVTIYFSDIVGFTTISAYSTPFQVVDLLNDLYTCFDATINAYNVYKVETIGDAYMVVGGCPVRIPDHASQIATMALDLLHQSGKFKLRHLPNTQLRLRIGLHTGPCCAGVVGLTMPRYCLFGDTVNTASRMESTGAPWRIHLSQATRDRLTQVGGYVIEYRGRTDIKGKGKMPTYWLLGKQDFDKELPVPPPLGNDYNPYTSAVQKYSRLSAMESANHRNELKHLNQMINDNSDDPEPMKNSKNVAQKKEASSENSVATTKNKKKPSERKDSEPQVLRRSLRIRKAVNYYPSIRHQLMITGIIEDILILETLQTSEQQQQQQQPQQQPSDSTSSLTAHLTGQLPTLNSTEDDSSAECSVAVSLPAVATTSRESHASPAKFAHSEQSSIDKGTGLKRVAVSVHEDRAAVLGQSFSMRSVGPSDTIDVAFCRDGTRSTPDYASATVTKSTSGDNPMTLGTPVSATEVAAALLGASSTSINSVSSSVFRGRPRRVGVIDEDDLSTPYNHYRCLSPNEHSYAGKTSFEPSIAEKSLHARRTLGRSRIKSLDIESSIAAGRAGGSCRLLRRQFSLDRADEPTGASSSGAASSSEQQVPLQHRPPPRLFKQNSAGAANDLERIEEVPSTPQASAGQTYRHSASVSLSVESLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMV0</accession>
    <name>A0A232FMV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pro-resilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000010">
        <property type="protein sequence ID" value="OXU32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMV0"/>
    <dbReference type="STRING" id="543379.A0A232FMV0"/>
    <dbReference type="OrthoDB" id="6365837at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF79">
        <property type="entry name" value="CUTICULAR PROTEIN 50CB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059435" description="Pro-resilin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="26177" checksum="0D55A2A11B282BD9" modified="2017-10-25" version="1">MNRLQFALLIGLCSAASGGLLPGDGYQYDRPAFGAADFGQRNNALGRLPTAGAGRGADGFGAGFNSRQPAGFGFPAGYQGNQGYQGYQGNAGYQGFQGNNQGFRGDNGASYRGFDGGDNGRSAPRPYSFQYEVRDAASGNDYGQQESGDAAGVVRGEYRVLLPDSRTQIVRYTADDANGYVADVRYEGQAQFPRPGFFGAGGAAAGGPGFFGGAAGGGAGGYQGRGNVAGYNGATDGFGVGGGASNQYLPPSAGSYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN10</accession>
    <name>A0A232FN10_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000006">
        <property type="protein sequence ID" value="OXU32104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN10"/>
    <dbReference type="OrthoDB" id="6258237at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF97">
        <property type="entry name" value="RE01453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU32104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="12778" checksum="B2BBA8F0B0791A40" modified="2017-10-25" version="1" fragment="single">ILGIICLACGSPALYGGTHWFLFVASTAFLVTIVWCVIYLISLREALKLPINWILSELINYALYTLLYFTAFVTELASAFLAKHIVAGVFGLLNNVAYAASTYFLYLEWQNSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNX6</accession>
    <name>A0A232FNX6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_012287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNX6"/>
    <dbReference type="STRING" id="543379.A0A232FNX6"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU32158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="131" mass="15067" checksum="D5B8355CF74FCA0D" modified="2017-10-25" version="1">MCLNSFTGVDWLKSLTKIQIPLLPKKEPTSKSPQPRPPTKEKNFPCPNCPTGFSEKASLTRHLRYECGQEPRFKCPYCSYRTKWTSSIYNHVRNKHDGEKVYCVDIYADEAVMAGKRSTMTAKTKNIFVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDS9</accession>
    <name>A0A232EDS9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005965">
        <property type="protein sequence ID" value="OXU16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDS9"/>
    <dbReference type="STRING" id="543379.A0A232EDS9"/>
    <dbReference type="OrthoDB" id="7696926at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="635"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="669"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="736"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="969" mass="109079" checksum="4D92A8CDC509B83C" modified="2017-10-25" version="1">MELSNDADRTFVLHNAVEHKNEYQINSLLLKNIDVNKLDKYNRSALHMAVIGKSQRIVAMLLEYGANPNLKEKRQGMTALHLAIKERELFIARLLMEKGANPNEVTKYNATSLHLALEVQDEELVKLTLEYGASIHAKKFGKSPLHLAVEHGNLAIAAELIRRGSNVDDTCIDGQTALHIAVEMKDALMTELLLANNARTDIKKFGSCPLYLAVKNDCIEITKVLLLASSVSNDDFKNRCIALELAFQKKNEKMVRVILEHGLDPNSKMSDKTPLHLACSCEWEGIVILLLERGADVRQVTSDNVSPLHIALEQGSVRIVELLIKHNADVNVRQHRTGVTPLHIAVKRACHESVQLLLAAGADANVTTNLNITALHLAFEARDREMIASLLAHGADPNLPKYGKSPLELSIECRWPDLARQLLQRGADPNSISSDQLPMIFNTIKQKNVELLQLLIEFKADINTPDPKSNYSPLMVAASCRCDEAAEVLIDSGADLDYATEDGTTTLHLALERRREFLVKLLLRKGANLEIKKRSLAPLHVAAECRWLDVAEVLLARGADVNELTIYFATPLFYAVEKSEFAMAKLLLRHGADVNYKWYGSTALHVASGLRQPEMVTLLLDWGARVNEYNEQDADCVSALHIALKNGDEKIAKILLERRASVKMRDRKMNRMPLHLAAESGCVEAARMLLARGAMANDTDKMDVTPLQLAAMRSRINMAELLLEHGAQVNARNRSDHYTSLHYAVIRRNYNMVRLLLAEGADVHCEDSLGTRTPFNLALQKFEDDRMLHLLLLEQATGPECMKQMLQHLGKLSSSSPIGEMLIRHLVRRKGEISRDELDTHRVCTDLQKYHERCVKEISELHKHVFYENVTLHTLLCKTSRELSLLARNESLVQAFEASGYQSKYPIYERILKDSMRAAQNMNKLTIGAENMLVRLFKRELPHLMNHMIINYLSNTDLRILNSIEMQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF22</accession>
    <name>A0A232EF22_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005125">
        <property type="protein sequence ID" value="OXU16969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF22"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="12247" checksum="27470F3089B1C185" modified="2017-10-25" version="1" fragment="single">DLFRATRTQISSFQGQRNGAGMPSTFSSSALGRVGVTNLERVVDDSNLYLLHFLIAPLALSTSWFSARRRVGPHVVVGGDGTAIPPPVTRVDFLRNDDAIPVEEALPGREAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF55</accession>
    <name>A0A232EF55_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005099">
        <property type="protein sequence ID" value="OXU16999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF55"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="16329" checksum="2EE8DEE1B9876765" modified="2017-10-25" version="1">MAVQFWGPGVEEVPEIEDDDGYASEVGSVGEVGKEVGVDGLNPFYPCHGMAGSSIYVDGRCVICRQPSASPAAMHVKRTDTGVQISYRVLSAEDEPSPGGWFLCHQEDWDAPEESCLVCEQSLRGVRMSGFPCLAWDEVPKQGLFLNLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFH4</accession>
    <name>A0A232EFH4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005017">
        <property type="protein sequence ID" value="OXU17101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFH4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="11487" checksum="E6006CC5CC81615B" modified="2017-10-25" version="1">MENMVAECLQLAKLLEEAEKLLHSAVADSTTIARWNKQFTLSLKTFRKVLSNKRLIVHEKQSILCTTAKIECIKARFDVMTRRKSDGGLQVQKKKIIDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFJ9</accession>
    <name>A0A232EFJ9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005023">
        <property type="protein sequence ID" value="OXU17092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFJ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="9019" checksum="163813BA417AF587" modified="2017-10-25" version="1" fragment="single">MTKIISREGRRARTLIRVLAPMIRPSEMREIIEGLVESSDLEIVKFCLEVYPQKSVLCLTHALNKGNEEMIKSLLEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGK9</accession>
    <name>A0A232EGK9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004751">
        <property type="protein sequence ID" value="OXU17468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGK9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9464" checksum="2A58A496A4FCE762" modified="2017-10-25" version="1">MEVPENWSTLSIDDKLAAVFRQVASANSNVGNLTVTTNNLNEKVDKLLVDISGHSKRLQDLEEENAILRTELTGLKNRQAREYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGT0</accession>
    <name>A0A232EGT0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004691">
        <property type="protein sequence ID" value="OXU17548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGT0"/>
    <dbReference type="STRING" id="543379.A0A232EGT0"/>
    <dbReference type="OrthoDB" id="249932at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="170" mass="19930" checksum="4F26451A04DABFAD" modified="2017-10-25" version="1">MTNAALCPNLISNYRTPKIFWYQTDNAVFIRIILTDVEKYSIRVDCDTFKFSTTLNDQKYFVGLKLCGTVVAEKTSHEKFGREIKVCLIKAHKWTDWPRLQMNKEKTTFICMDPDHIVKKKSWDDPFANLAERETFEEYRKRMNITNIPPPESSTSGSESDDEKYVGYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGT8</accession>
    <name>A0A232EGT8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004683">
        <property type="protein sequence ID" value="OXU17561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGT8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8458" checksum="E158D5F89D0463DC" modified="2017-10-25" version="1">MSKNNFRTLFSHRIPHSRKLQISESAFPTPIYQISKMQPLLPQGDFTANFTGLHTVIVKTIPLFIFCLFARYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHQ0</accession>
    <name>A0A232EHQ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004456">
        <property type="protein sequence ID" value="OXU17875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHQ0"/>
    <dbReference type="OrthoDB" id="7536850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6633" checksum="15ADEEE81AE6BAAE" modified="2017-10-25" version="1">MAQKNQNQTKRDLRVGTCNVCSLYRAGAFKELVKEADRYSLDFVEIQELRWPDGGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHY1</accession>
    <name>A0A232EHY1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01004385">
        <property type="protein sequence ID" value="OXU17966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHY1"/>
    <dbReference type="STRING" id="543379.A0A232EHY1"/>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06648">
        <property type="entry name" value="STKc_PAK_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000073">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="10">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="407"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU17966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="685" mass="76443" checksum="11B235F99FDB780A" modified="2017-10-25" version="1">MFAKKKKKPQISTPTNFEHRVHTGFDKREGKFVGLPLQWASIVGNNQILKSTNRPLPLVDPSEITPTEILDLKTIVRGHNDPRLGKSMVGEKVVESNLPKMSSVARSNSLRSSSPPRLRRDYRNNTNLPPSVPEGQEMTLNPTPTQMYSNYNNKAHGYPDKMRQNSPSIGPATNSGHNMIPNLQNLNPNMQSSPNLPHMSTNAQNLSMNFHNLSPIPSMQSPTSNPNIPQMQEYDFQRMNPSMPIQPGTAQYNGNMQSAKADPTRAGAAAQNMMIHNAQPKVSPVGSIASQRPLSQLSSYNVTKHTQNYGAAENPNFHMHFQKPIESSQSMHNLSKAGALSPMPGNSSTPDQNQNMKSAMSSGNLAVGSGAAANNTGKQNAEQRLTHEQFRAALQMVVSNGDPRENLENFLKIGEGSTGTVCIATDKTTNRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVEMYDSFLVNDELWVVMEYLEGGALTDIVTHSRMDESQIATVCLQCLKPLQYLHSQGVIHRDIKSDSILLTADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRYVKYFGLPYGPEVDIWSLGIMIIEMVDGEPPFFNEPPLQAMRRIRDMPPPKLKNSHKVSPRLQKFLEKMLVRDPAHRATAAQLLEDSFLMQAQSPSILIPLMRGSRHTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ93</accession>
    <name>A0A232EJ93_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004054">
        <property type="protein sequence ID" value="OXU18439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ93"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="8692" checksum="1B9F9AD7EAF01B53" modified="2017-10-25" version="1" fragment="single">MHLNENKITYFSSFGPRDRPLCSANKMKRGSKYLKRDKGMEAYTQYSDDSSEFSQASDIEDDIENSLTTVLPIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJI4</accession>
    <name>A0A232EJI4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003989">
        <property type="protein sequence ID" value="OXU18527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJI4"/>
    <dbReference type="STRING" id="543379.A0A232EJI4"/>
    <dbReference type="OrthoDB" id="10067479at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052852">
        <property type="entry name" value="SSU_Processome_Comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28366">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28366:SF1">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="192" mass="22206" checksum="57307F3B357896A6" modified="2017-10-25" version="1">MDGFIPTRAALKKKDAEKALVVTTFEAHKKAPSKPKVQSKKEKPVSRDSDDEMEDDDEPEEPLDERRKQELDMKRYRYDVIKFGMSGFEKKEARQAKIALAVSLGAIPPKNKRINYKRLLKERKEEKAKEKKKEKFASGFSSNQLLMKFKKNDKPKINNRKEKDGILGIYGKVTKDNNHKRKGGGRVQKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJK9</accession>
    <name>A0A232EJK9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_001161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003976">
        <property type="protein sequence ID" value="OXU18546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJK9"/>
    <dbReference type="STRING" id="543379.A0A232EJK9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU18546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="277" mass="32213" checksum="786276221E06272A" modified="2017-10-25" version="1" fragment="single">ESEEEVVPDKSGMEEIKAIKAWVIDTNIPYQTVDKLLLILKKRLLPQIPNNTQMLLKWDCNNFDNVDNAEVSDRPMGIQKALNNPNNDASNIDIIKMETINCKTDFAFFVTKSLTAIARYVADIKAKQDAMSASMAKKYQYYYPVTSLERFLEFDKVLENNKFLRFDVFVKPNLLGTKIEFRNRFDNPIVNGQLDNSTAKDLKLVKRELTFFTGTARAVFTTKARPILNVPKDHVLANVILKFKNYICQFFEHDSLLENKEEEELDEDERKQAWFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJU9</accession>
    <name>A0A232EJU9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003936">
        <property type="protein sequence ID" value="OXU18627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJU9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="174" mass="19115" checksum="46A095300D1F77F5" modified="2017-10-25" version="1">MSRANQRGPMRCLLSSRTGSQSEASKKRGPDDQERRASARTSGEIVAHRRFVRVTCVHLCLSTRGRRLEEIGQPVRHHHPKDPSSQQHRRGRAEAASCHQVREESTGSLKRGERVRTPPGPDGSWRLRLSHADVAGCSGPLDDGDELAGLLPLVRMVAGSSGRCHFLVPTMTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK42</accession>
    <name>A0A232EK42_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003899">
        <property type="protein sequence ID" value="OXU18692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK42"/>
    <dbReference type="STRING" id="543379.A0A232EK42"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18361">
        <property type="entry name" value="BTB_POZ_KCTD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048595">
        <property type="entry name" value="KCTD1-15-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF67">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN TIWAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20871">
        <property type="entry name" value="KCTD1-15_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="83"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="346" mass="37761" checksum="956A7E259BCB67C1" modified="2017-10-25" version="1">MNFDCRRKCEADGKDAKAELTAQRNMFPSAQIKMRLMSPSSSPATSPTMSNSSSPTPPTPAASAYNQKITGIPCVAAASRYTAPVHIDVGGTIYTSSLETLTKYPDSRLAKLFNGSIPIVLDSLKQHYFIDRDGGMFRHILNFMRNSRLLIPENFADLDLLLEEARYFDIAPMTRQLEQMKKERIKNGGAPSSSTPSPTPDQSNLHRNMSASSGSNNVGGGSHIPSTPSDSKLRTTSESYECVALHVSPDLGERVMLSGGRALLDEVFPETTQAVLEARSGVAWHQQDARHVIRFPLNGYCKLNSVQAITRLLNAGFRLAASNGGGVEGQQFSEYLFVRQSVVNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELR3</accession>
    <name>A0A232ELR3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline-rich protein PRCC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003522">
        <property type="protein sequence ID" value="OXU19271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELR3"/>
    <dbReference type="STRING" id="543379.A0A232ELR3"/>
    <dbReference type="OrthoDB" id="206969at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47892" checksum="1334F8B0F99E2577" modified="2017-10-25" version="1">MSLVAYGSSDESENEETNEQPQVEVKTDEEAVKIMSNSKLQLPSPKSKTVNDESATNGNDSIKEVKKINFEELPKPISINTAIDALETDRAPVPRKVDYGKIEKLPKKEKGPTKISIPSLSDFKDLEEEETEKKSYRRKPSEKGSGLINLLPPPSSATILTKTNKMVPHVLTKSVENKKLIPTKPVENVKRIQKPATQSKSATSTIKSLSNYSDSEDEDDHKTSSSIDFFSLSTPIKIPDELLPPMSKSDMDAINAIATKKKMYNKEEKLITEENQEESRTTLVSNIMNLPKEEILLKNKAEVGPKLPVPEQEYNVDSEGNVAFDEKAIEYLCGKRGVKRKNEFSNVDIVEISGEDIKPDEREWMVKALTEEKSNRPVSAGAGPSGQSKKKHQITYLAHQAKAMELELKNQWAENKASRQQTRSKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EML0</accession>
    <name>A0A232EML0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003342">
        <property type="protein sequence ID" value="OXU19594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EML0"/>
    <dbReference type="STRING" id="543379.A0A232EML0"/>
    <dbReference type="OrthoDB" id="8192126at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033773">
        <property type="entry name" value="CBX7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052458">
        <property type="entry name" value="PcG_PRC1-like_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389:SF3">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17218">
        <property type="entry name" value="CBX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="461" mass="50520" checksum="79CFA3222DE9D280" modified="2017-10-25" version="1">MRFNDFLIFCCRAKLNTTSNGKDGAKSEYNTWEPEENILDVRLIELYEESQRGGDVTARRPRRRDTRYSEQILANLVVEEEPGGDERVGEDSQDESATETSVAPVVAATRLSSTVDALNVDEDTLASSLDGHESPVPKPDHFSAVSDSESSNSSLELPLMPRRMPAGTKRKAEVLSKESGKIGVTITTSSPSSGSGSPPPSKKIKGSSSSPTYHTHKVNGRRPSSSSVKSTPEEPLPAVPTTPAPAIQDKKRPEADVPRGPPPSLPRAPSAPQSPQMDTPLEPSLQPQQTTKKKQQQQLAQSDHINKSQSPDKEKLQQQQPQPNGPVSVDANGHKSPSPTDSYTNNNRLNAGILNGHHSHNNNNNNNNNLNNNITNNNNNINNNNKSSSIKQQQTDMLKANETVYVPLTSPGTDYWHARNPVADQVFITDVTVNLKTVTIRECKTEKGFFRERDPKSDVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMM5</accession>
    <name>A0A232EMM5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003333">
        <property type="protein sequence ID" value="OXU19606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMM5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10222" checksum="F9931208B4E57BAC" modified="2017-10-25" version="1" fragment="single">FACQGKARKRRTTREFGLSLYDCMLRSRSAVGRRMCLWACVLEPTTNANSSLSPRSVRMYILGIRRLNLALSGMLSVAVNYAYFLRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMN2</accession>
    <name>A0A232EMN2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003328">
        <property type="protein sequence ID" value="OXU19615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMN2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="499" mass="55764" checksum="6199506541926CBE" modified="2017-10-25" version="1">MRVLQPASENFDPILWLELVIHDIHTYLVSMVSDSDLIGVTINSENFARGSAGISLRPVANFCVDDLWMLLSGVTQSNENFEVDDNFCIEATYVEVPLGTGKRKSFGINVLGQRSLIFIVRNCDNLCLPQSLVVGEAFLNLKEDATDAAKKVWTAIRDGRRSLKKDRAFMLTAAANLIIPANAVVVYDSNSFGYGEPPFFDGRATIRDVQPSKIINISYDARGHHYDTILNLTGAAKKERNHYVRRFRVNGVRIIMRVLQPASENFDPIVWLEFVIRDIQAYLVSIASDSDLIGVTINSENFARGSAGISLRPVANFFVDDLWMIVSGVIQSNENFEVDDNFCIEATYVEVPLGTGKRKSFGINVLGQRSLISIVRNRDNLCLPRENFARGSAGISLRPVANFCVDDLWMLLSGVTQSNENFEVDDNFCIEATYVEVPLGTGKRKSFGINVLGQRSLIFIVRNCDNLCLPQSLPTLSYLQMVVDFAKLKNFKTIMRLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMU0</accession>
    <name>A0A232EMU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_014866</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003318">
        <property type="protein sequence ID" value="OXU19632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMU0"/>
    <dbReference type="STRING" id="543379.A0A232EMU0"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU19632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="11763" checksum="BA47987E33C5E0F7" modified="2017-10-25" version="1">MGVPAGDVEKGKKIFVQRCAQCHTVDAGGKHKVGPNLHGLIGRKTGQAPGYAYTDANKAKGITWNKDTLFEYLENPKKYIPGTKMVFAGLKKPQERGDLIAYLESATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMW9</accession>
    <name>A0A232EMW9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003299">
        <property type="protein sequence ID" value="OXU19662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMW9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="123" mass="14520" checksum="4BFC681A1E67219C" modified="2017-10-25" version="1">MSVQSTSSNAADVVANVIKYAYVRFEDNSGLYVKYIKCIIEKILNPPGKVTFKKFLPKHDEDFDKNKCYYVKWECRKCYVRVAAQSEYSHDRNNYEFRVDETFYLAQFAHAIPLRKKVKKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENE9</accession>
    <name>A0A232ENE9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003183">
        <property type="protein sequence ID" value="OXU19851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENE9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="54" mass="6066" checksum="E53A63FA5566B4D3" modified="2017-10-25" version="1">MCVTPRIFPLLLRVCVRRMIFRIAVAGDRYLAAVSGSNDLLVCCQENYGCKSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENI0</accession>
    <name>A0A232ENI0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003712</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003140">
        <property type="protein sequence ID" value="OXU19915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENI0"/>
    <dbReference type="STRING" id="543379.A0A232ENI0"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="252"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="639"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="140"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="96781" checksum="E2F023EB7164D8A4" modified="2017-10-25" version="1">MMKFEVIKAEVDMDLPLSEAAMTKGISRDVVDPSEDSGFDSISVGSNSSTEQIKKENEGTIGEGIQFVDPALIAAEAEEQRLRAEEKKRKTNEELVAKRKAEQEAYEQEIKEKQYKRLMHLLSKSKAMSNFIMSKFETKKPKEEAKKAKEEPSKALKRKNTKEVESPVPKKRGRKPDKKYIDGAAEENPEPKRGRKKMNLSQEDISEELASMSDDEPSEEKENEKPIENFVQSKYFHGELRDYQKEGVNWLKVLYENGLNGILADEMGLGKTVQIIALFSYLIEKQIAGPYMVVVPLSTLANWTTEFERFAPQLPVVVYYGYANQRSELRKKLEQKKRIGSLYTLPIVLTTYEMPQKDAAFLRNFNWRYIVIDEAQRIKNYNCLLFRILKSYNSFNRLLMTGTPLQNNLSELWSLLNFLLPDIFNSLDLFESWFDAKDVQNEEGKQKFLKQEQEKQVLSALREILQPFMLRRLKEDVCPDIPPLKEVMVYTPLTAIQYNLYSSILNRDIAKLQKVKPESTILDVNGVRPKRRCTQKHNLGENYWRNDTGINDFAKKSEVATEIIGNKVVKAEDLNMWNKFTDVTEENVDYLVRLKLSGNDVTMYRHVVNHPYLIHYPLTDAGDYKVDENIIKASGKILVLDALLKKLYKNGHKVLLFSTMTMVLDVIEDYLTLRGFKYVRLDGAVAYDDRKNSIDSFQKNPEVFLFLLTTKAGAVGLNLAAADTVIIYDSDWNPQNDLQAMARCHRIGQTKPVAVYRLCTKGTVDEAIIKRANAKRFLEKAVISKETGLVNSEEGLSRLKKLFEEDSFKVANSKNEVYTDAELDELLDRSDMILSKKEEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENK3</accession>
    <name>A0A232ENK3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_003715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003140">
        <property type="protein sequence ID" value="OXU19918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENK3"/>
    <dbReference type="STRING" id="543379.A0A232ENK3"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000020">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013393960" description="TIR domain-containing protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="836"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU19918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1017" mass="116614" checksum="0D9FB24C7C85C655" modified="2017-10-25" version="1">MSRLALPLAVLLLAIFTASGSFSCPKRLPCHCYSNDVNTYAITCLTNAFTNSAFKITYQPGDLVQIQCENSPNWSRLLQGTIIDIGFVREFVFTDCEPPGPAYSSRIINEQLRVQNVKYLKYENLIAPLSAQDLDVFPDVKHLELTNNPLGELGVPRDLLRGLPVLNILELRNTNLQKIPRGFFDNSRFLRTLELSNNNIKSLTPGVFDGLEKLQLLNIQENDLRELKPDLFRGLKSLESLDIHQNSLKTLPVDIFADLENLESINLGVNNFTSLPDDLFLYNPKLKVVKLLYNKCNLTTLPSRFFSNLTNLKDVTLMRNGIRYLPEDLFWYSTNIVKLNLNRNYLQTLPFNLFKDITELETLTLFFNDLQYLDAGIFFNNKKLRKLDLSKNRLRFIDELTFAGLESLQELFLEYNELSYIDAKAFAPLGQLRFARFANNKLTLDNSLADDFGQFSPFYSCSSLEELNLAHNNITKMYSDWTITGTNLRILDLSYNSFESLQAEDLQFMSNNIEVDLRYNNIHHVNLANLEFISANESGNPRQASIFLSSNPIHCDCKIYDLVRYLDQQMDFPSSTKIYVEDMACDGPKHMAGLLVSRLKSHSIKCLTETCTSDSTCDCWMRPSDSTLLLDCAGRNLTNPPSWIDTHGAERVELDLSRNKLGKGPNMTAKGYNKVVRLNLSENKIIAVDESLITPKLKILNLHDNKLTSMNSEVLRKLANDSMISQLTLRGNPWICDCSSRDLLFYVRSSFKQLPDLLNITCRNSNVSLSSLLPVELCPTSNRLIIMIYLIICLFALFLGCASALYYQFQERIKVWLYAKNLCLCLVTDDEMDRNKTYDAFISYSHKDEEFVMNELVSKLENGPKPYKLCIHVRDWLIGEWIPMQIARSVEESRRTIVVLSPNFIESIWGRMEFQTAHKQALSDKRARLIVVVYGEIGPTDKLDPELRAYLQMNTYVKWGDPWFWQKLNYAMPHLARLPEQVDQENNCSSTINRAIVDEKQINEKETVIETLKEMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENS4</accession>
    <name>A0A232ENS4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003087">
        <property type="protein sequence ID" value="OXU20004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENS4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="10018" checksum="98EF5C420FB85CFA" modified="2017-10-25" version="1" fragment="single">MVHRYESISLHGKKKKHAIVRRLAKITVEFSSFKESVRSFLLVSRVRDQLYESRLAKTTSGTPLFLLNSRYGRRTVKTTGLYSRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP04</accession>
    <name>A0A232EP04_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003048">
        <property type="protein sequence ID" value="OXU20056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP04"/>
    <dbReference type="STRING" id="543379.A0A232EP04"/>
    <dbReference type="OrthoDB" id="7686632at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="248"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="609" mass="69868" checksum="DA68C800115872DB" modified="2017-10-25" version="1">MQVSVVIGDLHVDVNFMMVAQANFCTNLCQEGDNYADLTDNSETDLSNTEIDQKLVSVTGLDQDEQSDPCQISLKNSDMSLERNQEDFIKSRPVEIQLRKVRRDEIHRMERLGIIERSDTIYINSIVPVFKKNNSVRVCLAALDPNEQIQLLKKGTKWRWTEEDNIAFKKVNQLFISDILLSHLKLDCPFFLRTDSSTTGHKGSEKIVITPELVEILIRKTHIQFGHVGAKKNKTYTGGTSALSSPIIPEGPRDLISIDFCGSYPTGQRGVKYLLVILDTFTKYVVIYPIVKATARITIKKIFDDYIPLHGRPERIQADHLTQFTSKLWLNKLKDEQIVAMFSSIRHPQSRFFRSLALKKHSAWPSWIPFIESCLNESYHDTTEFTPLELQTGKRPSRFWENLVTVPQRTDLLYAEKLALVNSRIKIKGDTRAAKINSSRSLKMYAIGDKVLAYACYFSNASSQVSVKFMSLYEGPYIVCAVYNECTYKIAYPDSEQIRGTFHSSELRPYYETETPGTKYPRPLKGHGTFPQNNIAETHEEEITSNLDPNPPLSHKPPSPTFEKRRQKREEFIRKYRARIVKKRTSPQIPPDNECDVLVIEENLELVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ93</accession>
    <name>A0A232EQ93_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002812">
        <property type="protein sequence ID" value="OXU20524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ93"/>
    <dbReference type="STRING" id="543379.A0A232EQ93"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="60793" checksum="BD19CEF404AD66D8" modified="2017-10-25" version="1">MKSLLVFIPERFCTEKPGCMYGNVLYEPNEDISKFYILGLTESVQSITRASNDLVPLGYFYGAEKKIEYWEKKLPNWIELYLSPQSSSNYEYCMRNVMLKNQKLALLDCHTVVILYEEHCLLRAELYSEKTPMDHFSELRTILAKESTRKSQDKLKNVCVDHMRETIFNVLILSFLYPTTWLCKITNALNPILKYSSLGLHLTAWFHNAKWTLSTLSLSKRFTLKTTNYILAMAVDMVLGLLLLKLLLHFLGDSSPSDVLLFHAEKVVESLKGLVNWLMGSPAGLKLNRSFNNVLGKFFLYHIHLWWAFLVVSKPLMELAFGVLLFFGRLGVTFQISIVADLLALISFHTYCIYIYAARLFNIQIRGLTALFRLFLGKKKNPLRKRVDSCRYQPDQLFVGTLLFTILLFLMPTTWLYYIVFTVLRIIMIGLGGFLTRLKFYLQIMPIYAYFRWLFRTVDATGSIGIKLLNREVKGPIMLRTKAIIAPWSETWRKSIPDTINIHPPIEWSKIASSIFWGQLLYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQU6</accession>
    <name>A0A232EQU6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002707">
        <property type="protein sequence ID" value="OXU20734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EQU6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="929"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="969"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="99"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="411"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="698"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1305" mass="147908" checksum="B09F3A3A32C55DB5" modified="2017-10-25" version="1">MDGSLRRKPPNPSPKLKANFVSRLSFWWLGELFWDGKHRNLQANDLYDVLPENISEPLGDQLEMSWEKELRDAADKKQKPSLWRAVIRTFGWPFVKYGFSMFLLNVVKILQPLILAMLVWYFDPQSTMSTEEAYMYATGLVLATMMQTVIVRQAHLGLQEIGMRVRVGCSSLIYRKVLKLSSASAGQAAGGLIINLLSNDLTKFELFCLHLHYVWVMPFVVSLMTYLLYRQLGIAAFTGIALMTVQILPMQVCWYKLTKMLRAKGAVRTDKRVQLLGEILNGIQVIKMYAWEKSFEQLVYLARKIEIDALLKRFYVRSVRVASTVFTYRSAVFFTILVYVLEGHVIVADRIFSMIHYFALVRTIMASFFPEAVSLAAEVNVSMKRIENFLLLEEVDPDVKRPAVGDDGLVVSMKDVSASWEKEAKADNLCDINVSVPLNKLWAIVGPVGSGKSTFLKLILNELQPRSGQVLVRGKVSYASQEPWLFSGSVRDNIVFGDVYDVEKYYRVTQACALLKDFEQLPYGDRTLVGERGMALSGGQCARISLARAVYRDADIYLFDDPLSAVDNRVGRSLFEDCINGLLKGKTRILVTHQVQYLKQVDHIVLLNNGRLEFQGTFQDFYNNEQYLKYLPSKEEVEKLPLEESGVNKIEKVEPVSKSDKEDDREPKETAELLAKGRIPKSLYLKYFKSGASYFIFALLMMCFVLTQFAISGFDYWIAYWTKQEEKRMRLSLNMTTALDPVNTDDFISEITAVSVYGGLLVAIVVLSIVRNLLFYKTVLNSSKNIHNRMFSRLVRAPLKFFNVNPTGRIINRFSKDTGTVDDTLPTSLLDVSERILMTAGIVIQILVVKWWSIFPMLVIGYLSARGSDVYLSTMQNIKRLEGSAKSPVFSMVNTSMLGLLTIRSCRAQKIVSREFDARQDDHTAAHNLVLVAAGAFGFWMDMITISFLTFVVYSFIFLNDSETFAGDVGLVVIHILNVCGMLQYMIKQVTEVVTQFTSVERMAEFTKLEQEEPSKTKPASIPAITWPEHGEIRFEKVYLRYCEEDEPVLKNLNLTIDPNSKVGIVGRTGAGKSSLISALFRMAKVDGSLLIDKLDTKDISLFDLRSKISIIPQEPTLFTASLRDNLDPFHQYDDASLWSALEEVELNKTFDSLDHLIERGGNNLSAGQRQLLCLARAIARKNKILVLDEATANVDPATDEFIQRTIRLKFKDCTVLTIAHRLNTIMDSDKVLVMEDGEVVEFDQPHVLLQKNDGYFSKMVQQSGNAMSQHLKRTAERIYNENVKNSSKKSVPNVDVNKISRSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER54</accession>
    <name>A0A232ER54_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002678">
        <property type="protein sequence ID" value="OXU20797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER54"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="147" mass="16703" checksum="92BA62C5172BBD99" modified="2017-10-25" version="1">MYSHLITGTFASILTNRIESILYESIQKFALNVEVAPPISNKTPINVPANIQNYSSDDSLGPNVTRDPWESCRKKRNKTQKMQNTSFPYSPNAQKLFDRYASKSAGHNHTLTCNKNIKDETKRKIRLLKQGNQSGQLHYTSRCQIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERE6</accession>
    <name>A0A232ERE6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002612">
        <property type="protein sequence ID" value="OXU20940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERE6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18014" checksum="176BB612F799E896" modified="2017-10-25" version="1">MPGENATDEVISDSNKAFRINNFNIIIDTAVSTLERRFEDFNNKLYADLAWLDPRSINEIRISGLQAPTIEVLCEKLISFEPDMTAKNRVSYSKMESSSAGSVTSQSAIFYKCHPKCQDSTGKGFKELVGRTLESYNISIKQCVGTSTDGAANMQGQYDGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESI9</accession>
    <name>A0A232ESI9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002414">
        <property type="protein sequence ID" value="OXU21329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESI9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="149" mass="17047" checksum="707C5A22AC519848" modified="2017-10-25" version="1">MNKESTRHCCVTEVSEPILIPHKVWRSAALTLYSFKALDVRSFEVALRLPSMQARFSSAKLSRGSLELEKPNRNVAGQKFLDDEKITSFNPPIAKQKYLYEYVKSQDYPSTEIDIRHKTTTPTPHLSAFDHIADSGAEQTTKKYEHVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET62</accession>
    <name>A0A232ET62_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002323">
        <property type="protein sequence ID" value="OXU21549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ET62"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20030">
        <property type="entry name" value="FH_FOXN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000027">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="182"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="8">
        <location>
            <begin position="182"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1537" mass="176733" checksum="472774A1E32C66EB" modified="2017-10-25" version="1" fragment="single">DAVSELEPLSGSLDQDAESEPERDYANELNDPACFKMSIPALLAGQKSKPATLLLPAGSIKTLSPQLIQAAQQQQQQQQQQQQQQQQQQALKVNGHNITGIRLQNLKILQSPSNAATPQQLRRQIYNNNIQLVTQQQTGTTLLQQQQSQLAQLAAANCQQQQKRDKELDPLGHDYDEKPYPKPAYSYSCLIAMALKNSQTGSLPVSEIYNFIEHFPYFKTAPNGWKNSVRHNLSLNKCFEKIEKPAGNGNQRKGCLWAINPAKIAKMDEEVQKWSRKDPLAIKKAMIYPEQLELLERGEIKYVGSGSGGELSEETESSADEAEGLEEAAHPFGGHILSYLTANSVTDSYDESSLDFDIDISEQTYDEIDIDENKEALHVQLNISSAQQDSPVSLSEYQQYSPSAKRQKTLTGTLQSNYIYQSVTTARRKTPLFLTTDKIFQRMSSCYKLPSLLTKTCIKCNGINEVINRCIMPKRLLQSSSRSKKIKISATLTQNINFTRSKSSRLNLQVDNQSQKIELPKANMTVNNSESEKEAKREIKVEYLDTPIKSESDKKEYRVIKLSNGLTALLISDVNSMKDGACPASLEDGKDKACSLCVGVGSFSDPNKIQGMAHFLEHMVFMGSEKFPQENDFETFIKKRGGSDNASTDCEQTTFYFEVQENHLLPAMDRFAHFFISPLMKRDTITREREAIESEFKMALPSDSNRKEQLFCSLARKNHPATKFPWGNLVTLRDNIDEDELYSELHKFRERHYSAHRMTLAVQARLSLDVLEQYVKDCFSDVPINNLPADDFSKYKGQDSFDNPEFRKLYKIKPIKDVCQVELTWVMPPLHHLYKSKPHQYVSWIVGHEGKGSLINYLRKKMWCLNIFSGNGEGGFEHSSMYALFSLSLVLTDEGHKHFKEVLEAVFSYINLLRREGPQKRIFDEIQQIENINFRFTDEDDPVDYVEALCENMHFYPPADYITGSELFFEYDPESIKNCIDALSPDNVNIILFDKKFNEEEFDKVEPWFQTKYTSSEIPQEWVARWKEIDPLPDFHLPHPNIFITDDFSLIDLPSDIPNYPVKIHHDDKMEVWHRVDAKFRLPECYIYLYLITPFATVSPRFSAMLNIFVEILKQLLVEDLYDATAAELNFQIHTNDKGLTVKVYGFNQKLPLLLRTVIKYVADCHKIATEELFNVMKKEQLKNYYNTFLKPAKLNKEVRLSILTSGFWNSIEKHTAVSDVDFKQFINFAKHLTDHVYIQCLAQGNMTQEDVLKNIFQCIEPLKCGSLLMEERPRIKVYEIPSGEKCCKVKNFNLMDVNSVITNYYQSGLASIKLSALIELLNMIMEEPLFNQLRTIEQLGYNVFCLIRDTYGVLGYSITVCTQANKFTTEHVDERIENFVQYIVKTLKEMSDEEYGFIKESLIKLKQCTDLHLKEEVNRNWSEITREEYIFDRYNKEISAINNITINELRQWLDNHTINGKNFRKLTVQIVGISNPTKDKESIDNPNLDSESKTYSIKYLTDEDSEKKKPLNYYITNIEDYKSSLIMFSQTSHPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETN0</accession>
    <name>A0A232ETN0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_000499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002259">
        <property type="protein sequence ID" value="OXU21702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETN0"/>
    <dbReference type="STRING" id="543379.A0A232ETN0"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="58"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="228"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU21702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112070" checksum="71A375C7404639B3" modified="2017-10-25" version="1">MSAIQRGLQRPMLGPGRSWAFRNNTSGLLVNSSRCISKSREKELLKRHEHSLRGKVIAIRREDQSVWERRAPLAPSNVRRLIRAGVKVIVQPSNRRAYPAGSYLAAGAQVQEDISTASVIFGVKQVPIDALIPNKTYCFFSHTIKAQESNMPMLDAILDKNIRLLDYEKLTDDNGQRLVAFGKYAGVAGMVNILHGLGLRLLALGHHTPFMHIGPAHNYRNSGMARQAIRDAGYEIALGAMPKSIGPLTFIFTGSGNVSQGGQEVFQELPHEYVPPEMLRKVAEHGDTNKIYACEVRRRHHLERKEGGGFDPEEYDQHPERYISTFSKKIAPYASVIINGIYWAVDSPKLLTIPDAKNLLRPAYTPWLPISVGAPALPHRMLAICDISADPGGSIEFMNECTTIDTPFCLYDADRNKDTKSFKGPGVLVCSIDNMPTQLPREATDFFGDLLFPYALDIIRSDAKKPLDEHNFSPAVHGAIIASNGELTPNFQYIQDLRQQNTIRSRHKDNGDVSKSRTVSVSSVSKLRSDLLRARKVVVLGAGYVSSPLVEYLHRDEDLRIIVGSQYKDEADALAQKYPGVEPVLLDVVERPEGLDEIVDTADIVVSLLPYSLHHIVAKSCIQSKKHLVTASYLNDKVKALHEEAEAAGVTILNEVGLDPGIDHLLALEVFDDIRQAGGRVESFVSWCGGLPAPECSYNPLRYKFSWSPRGVLLNTLSPAKYYHEGQIVEITGGGDLMSTVQQLDFLPGFALEGFPNRDSTIYKELYGIQHANTVLRGTLRFRGYSDTIQGLQLLGLIDPNAHPILHPNGPDITWVMSFILLNNSFNIMKIVNEKSDLLQRSVVCNLLGLANDDIFYENLKQKLAERLGSEERAKSIEDLGLLKEDPVLKLNTPLDTLSHYLSKKLVYEKNERDLIILRHDIGIRWPDSRLEQRGINMVTYGDVKGHSAMARTVGYPTAIAVKMILDGEIQQRGMVLPFTPDIYRPMLTRLRAEGLESFETSKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETP3</accession>
    <name>A0A232ETP3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002252">
        <property type="protein sequence ID" value="OXU21723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETP3"/>
    <dbReference type="STRING" id="543379.A0A232ETP3"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114191" checksum="090A0BF91B6762BD" modified="2017-10-25" version="1">MDVTNKVAIVTGGLGGIGFSTVQHLLRHKAQYVAVLDLPQNNSPHVVDGLKTLEEEFGKGKFGYYHVDVANAESFAAVYAKVVEHKGYVDILVNNAAVAKDTEIDLTIDVNLKAVIKGTLHAIEQMGVHKNYKGGVVVNIASFLGLVNRPAAPVYNATKHGVVSFVRSMKEHNKFFGVRIVCICPGMTQTHLIGVDTWRKTMLDFVPTEAIEDAFSIHLQKPDNVASAIVEIIKKGNEGDVWVAHNDELPFAVGEITDSYITLSQSRFHKSRTSNVIFLHYNHFVFWISSKMNIIDKVAIVTGGLGGIGFSTVQHLLREKVQYVAIFDLPEYDSPHVVEGLKKLDEEFGRGNFGYYHVDVANTESFIAAYAKVVEHKGYVDILVNNAAVADEKDIDLTINVNLTAVIKGALHAVEQMGVHKNHKGGVVVNIASFLGLVNRPLAPVYNASKHGVVSFVRSMKQHNKTLGVRVVCICPGMTRTNMVGLDTFRKTMFDFVPTEMIKEALNVQLQTPDNVASAIVEIIKKGDEGDVWVAQNDEPPFAVEEINDVEKMRIPRSNWWSKRYWFVAIFDLVVEEHEEVVNALKQLEQKFAAQRFGYYCCDVTNFKKFIACYDEVYTTSGAVDILVNNAGVFEEHDQDLTVAVNFTSVIHCTMHAIERMGTHKGGKGGVIVNLGSICALISLSTIPVYSATKGALAFFVRSTKDYNEKYGVRIVCLCPGMTKTKMTHAARDAKSYCLDFVPQKFVDQHISMHLQDPNSVASAVVEIAEKGKSGDIWLQCCDQPPVDWENKKAYVAIFDLLVAESDVVRAAFKTLEQEFDKVRFGYYHCDVVNHEEFIAQYNDVTNSIRNVDILVNNAGICNENDPDLTIAVNITAVIKCTMYAVERMGTHRLGKGGIVVNIGSIFGLTNIPTIPVYNATKHAVVSFVRSLKEHNENLGMRIVCLCPGMTKTSMTTAHNPRDILLDFIPQNIIEDHLELYLQDPNNVAAAIVEIVKRGKGGDVWLVQNDEPPFNTKDVTEVEELRTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU56</accession>
    <name>A0A232EU56_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002164">
        <property type="protein sequence ID" value="OXU21900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU56"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="69149" checksum="6D37488426C4A9A0" modified="2017-10-25" version="1">MVLNLIKPLNESRPWDFIMHGEFPVNDMYAHYGEIYLFDSLACIATVLVFCTVDSMYATCIEHCIGLFAIVKCVFICFYENSCMSDKIRITTTDRRSRLELSTKFVNREGVLGIKRDDMVYDLIVKTIKLHKKIINFTHILESSYSTSFLILMGMNMLYCSLVSVLLIIKSDALMERIRYGTILLGLLIHLFYISWPGQKIIDLSTGLFEDAYSNEWYETSIRSQNLLKFMRLRCLTPCQLTAGGIYVMNFANFASWSSVQRRAPDRASTSYVHLFRLVGLMPFEARSFDFLGTRLLTVNFVLFVGLDCSMFICYTINHLKQQETSCRGIEKKIRMLFKCLFSTTMLNIIFYFMKMLTTRLPPLEPGGPERKVLLFKYYVDEVSTSPAYELVVTLQTAVCYNFAIVLLVQDIFVPLLIMISCGYLRVVQNRLLNIYELDSKDDALDDSIDDCYKFHQSTLDMCLKIKKLSPTLYLVHILCTGYVLSLFGLKFSTSKSSNSDRLKSLSSMMMLVVQLYIYQWAPDQLIRESEAVSTAAYFANLPRIGSPGNRKILSIVMQRAHKPVILTAAGFVRLSIESFGSMITSAVSFFAALRSISIRDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUI5</accession>
    <name>A0A232EUI5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002129">
        <property type="protein sequence ID" value="OXU22001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUI5"/>
    <dbReference type="STRING" id="543379.A0A232EUI5"/>
    <dbReference type="OrthoDB" id="42462at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="317" mass="36038" checksum="5E580902463C7453" modified="2017-10-25" version="1">MPLPAALAARLAKRGLLNSNNKKADPSKKEPKRKVHEEVIAEDYDTSKEEISQIDIAQKFMGYSGCPNKYNIYHECTRKCKELWGKGHIQPSERYLKRQMKLVQKYPLPETWKAIYDPGTGRHYYWDWSSDLVAWLPPSHPRCQISQPASQLREELHLKEAEQDDNMSSDESGSDQEPAEVDDQEAKKKRDDVPQKEARDKDSSNRDKESVRERYKGGDSRRYQKPDKNKDGNKKDRTLDPMDPAAYSDIPRGKWSDGLAKQNEAKTGADTTAAGPLYQMRPYPSPGAVLRSNKTSKPEPESGTGKSKAVSFPEEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUI8</accession>
    <name>A0A232EUI8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002118">
        <property type="protein sequence ID" value="OXU22028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUI8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="71" mass="8137" checksum="C8A82C6B28E4EB6B" modified="2017-10-25" version="1" fragment="single">MNHQPCGRPTKDNVDISQYNEFIAFLKRQSTVYKGKKSKVLTSTEIDQFLTQAPDEIHLPTNRLGIKAVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUS1</accession>
    <name>A0A232EUS1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002091">
        <property type="protein sequence ID" value="OXU22102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUS1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="429" mass="49037" checksum="5EC71F547686CAF9" modified="2017-10-25" version="1">MNNTSGNPNDNSEAPTVPNVPRSTFRDERPCVIPTIINHSRHSGLLTNFYNLTNSYQPPISKPQQSVVSTKFPTAPYCQIPREQVLQLAQTHVQPNPVYNNPPLNFRQSVGSTAFPTTPYYRNPNDQVFKMPQTPVRPNEVYNNPPFNFRQNVVSTAFSTTPYYRIPKEKILEQPQTHVRPNEVYNNPPFNFRQSAISTTFPTTQSRPIPKEKVLELPQTHVQPNEVYNNPSFNFRQSAISTMFPKTQSRSIPNDQVFKMPQTHVRPNEVYNNPPFNFRQSDVSTTFPKTQSRSIPKENVLVLSQTHVRPNEVYNNPPFNFRQSDDSTMFPTTQSRPIPKDKVLEQPQNLPVFINGVSVKNEAPTPDDSVINLNKYELPVLESDAATNKENSDPLDLSANSENLNDLLVKLTMDKDKIEEKNDSTEYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV05</accession>
    <name>A0A232EV05_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_014034</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01002067">
        <property type="protein sequence ID" value="OXU22173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV05"/>
    <dbReference type="STRING" id="543379.A0A232EV05"/>
    <dbReference type="OrthoDB" id="10029630at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF45">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669423" description="Angiotensin-converting enzyme" evidence="14">
        <location>
            <begin position="20"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="6">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU22173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="670" mass="78093" checksum="B038A82A784CBB49" modified="2017-10-25" version="1">MKILGIVLLLVVGAQGSLARYLEGLNVNLGEALQFLREYDREASSVCNRVMTAQWNFATNITDSNRRKMVRIKIIVMKCQRLPLGNIFVLPDQLEEQTVKLKFERASWRKTVSFAWNRIADPLARRQLKMIAVKGRNSLTDDKFNEMHHLIMEMKELYNRVRLCPYRKIGATCDLTFDTDVMRIMSQSRDYDELLHYWQAWHEAVGPPLKNKYVRYVQLANQAAKLNGFADAGDQMREIYEDDYFQQNIAEVISAITPLYKHLFTYVRSRLIERYGDRIRNDGPLPAHILGNMWAQNWENVFDLVQPFPAVKKLDVTLDMMIQGFTSLRIFQMAEEFFTSMGMKPMPPEFWRSSMFEKPIDREVKCSSSAWDFCNKIDYRIKQCTKITTDDLVSTHHEMAHVQYYLQYKDQPYIFRGEALPGFHEAVSNAIGLSVFTPQHLHRIGLYNNATDDYESNINFLMLMALQKVAYLPFAYIVDQWRWRVFSDGVTDMTTRWWELRLQYQGIVPPIPRTERDFDPASKYHVPADLPYSNYFVSIILQFQLFESLCDISGHTGDLHTCDLYRSREAGRLLSDVLSVGSSMPWPDIIRLMTRGRTNRIDAGAMLRYFQPLTQFLRRQNQIEPVIGWVISQEDTALFAHWYLGSANTIASSVTILPTALLVCFHWLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVH5</accession>
    <name>A0A232EVH5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002003">
        <property type="protein sequence ID" value="OXU22337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVH5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="42" mass="4890" checksum="DA3BC98872A6DCB5" modified="2017-10-25" version="1">MVLNMYNKKKKDAGVCSNICFFSVFPTIENSIFLQNSPYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVJ0</accession>
    <name>A0A232EVJ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001995">
        <property type="protein sequence ID" value="OXU22357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVJ0"/>
    <dbReference type="STRING" id="543379.A0A232EVJ0"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="804"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126629" checksum="1D6DF4F0105676A9" modified="2017-10-25" version="1">MTNNNANSSTGVAELFHMLESNKLSEVEEIKKVFHDHFLSTKDNWLVNGLFDYYLSTDSLRAVEVLAGVREPHDKHLFDRLTETLTAKPANNGQKVRTLTLLGHVARRQPTWLFKLASHTLFRQLLHLLKVEEDIVLLMSALLLLITLLPMLPTALTPHLNEIFEVFSRLASFHYHRFISISSAYSVSFSTISMLNQHGGCDADQLYLLHVQVGLHHLFYRLYAMYPCNFVSFLKQQYLQRDQLAIFKKIISPMLDSVRMHPLLVTMSKDSEISSSRWKKMEHHDVVAECGRFSLLERSNRDEAGVPIANMRFTPISDYSCPYTPISSNSEFPMVMENTGLPNGSQDGSFWSPSMVVSPQSPPPANSLQATPLSQHEAKSTPTTPGAASLNISAGSTAVSNRSRTSPPEAAVEATPETTPVKDARQMTGRQLPVGSAAVRALSAFGNNGLLSGATSSSRPSTPTPVNHLISASSTAASNVSAALFSSLADSGSSSSIFDRKLNKIVADRQNAQQSTMALKQEEEVFVTSSTTTSVKRMSTPTATQMMMAQVTTEQVNAMLNGRVEMQQHQIEDQEVSDIVSARRSTLFETKDCSEKEIQTFNDLSRKVLLKFYCKNPTPVLSSKTRRRAKSCPDMKSVSRPEETSERSTQTCGLLPYECFFLDILDQRASNEAQANIPESARLSPSAMLERYIEVCSRNTSYGETKCRSKQSWPGGRRSTKPDDEENSAAASQLQQQQQQSANDDVSSESSSAGCWGEMDRANQQIQLMLMQLQFERQRREVHAERNRRLLGKLRDSRALEELNTAMTKSLKISENEIEALKSELSRSKLELRTELNKQKEAIHHWQTKCNEEQQRNAALNDRIESLEDELKSEKKKVTDHESKTRAAEATLFEAAHQLKEALRAANQSEELKRVLESVQKRFLLLGEAQARIQEKINAPVHMVRQEAAQIQRSWSEEVSSLRRQLDSQTLHLESLKARLADLEHKDARKEVQLVDQQRLLQESKEKHSAELEAVESKYKAQMEINLLLEGRILELHGKLEQATFGMSSSSGTVNLASSASPKERSPPLSASLASSSEGSLAFIHSAMNDCCDPAGEIANLQAIVEPAAGPSSSASQVVITSTAKTIMANSSTTAAPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVR3</accession>
    <name>A0A232EVR3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001963">
        <property type="protein sequence ID" value="OXU22435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVR3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14055" checksum="50EC6D8922BCE57C" modified="2017-10-25" version="1" fragment="single">LFLQFSYDSSKVSDSSGVSGITVTFGCEVTDTLTFDVRIKKTAEYKTKNARFDRSIPDDKDVNKLAVSGSGVGETVSLAHINAKRVPEMARAYTPWNRLYTLIHSCTLTTFPHAKLSSAQRSSGANCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVY6</accession>
    <name>A0A232EVY6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001933">
        <property type="protein sequence ID" value="OXU22512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVY6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="142" mass="16433" checksum="1F11BB010E71D710" modified="2017-10-25" version="1">MTENITNGQTLTCQSKIIDSEFRAGSQNQRNKQQNLMMFVVTNYENKKEKNDYKYLKTIFSIGLVASSTDRKSINDLKFSGVWDLTYEVSHVNVRSLTWNRYFAICRKTKVFVIEESRGALMARCLTVNSNPDFASQNSQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX23</accession>
    <name>A0A232EX23_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_012845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001793">
        <property type="protein sequence ID" value="OXU22904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX23"/>
    <dbReference type="STRING" id="543379.A0A232EX23"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="270" mass="30749" checksum="DAA2BD35B1E2861F" modified="2017-10-25" version="1">MRYGQLVIGPAGSGKSTYCSVMQKQGTDERRTVDVVNLDPACEHFDYQPLADIRDLITVDDAMEDEELKFGPNGGLVFCMEFLTQNLSWLEEQLGDTDNDYIIFDCPGQLELYTHMTVMKQIIRTLQNLNFHLCVVFLVDSQFLVDASKFLSGTMAALTAMINLELPHVNVLSKMDLLSKTARKQLDQYLEPDPSSLLAEENDDEYQTLTHAIARVIEDYSLVRFLPLNIKDEESIADVKLTVDNIIQYGEEEDVRMRDFDEPDPDEDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXB2</accession>
    <name>A0A232EXB2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001762">
        <property type="protein sequence ID" value="OXU22995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXB2"/>
    <dbReference type="OrthoDB" id="9995573at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="146" mass="16997" checksum="FEBFAD2D892A97C8" modified="2017-10-25" version="1" fragment="single">MLSKEKEKLLRTRSNYESDLKINNLSKTGIKKRCAFHEIKDHHSMENLFGVLKPKYHFVTHYPRVLLQNGPCVNFGSMRFESFHSKIITTAQSTASSKNSLKTIAVKQELIMCKLFDSMKIDLKDDFKLCSRDDSDCEAKPYFYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXC1</accession>
    <name>A0A232EXC1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001772">
        <property type="protein sequence ID" value="OXU22963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXC1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="150" mass="16300" checksum="65E49EB127DACD00" modified="2017-10-25" version="1" fragment="single">MNARIPRNIAAAAAVAQCRGSAASLSMADITSRGYWPVLPLDQQCSAAAAAAAGNPHAERVGSEETTKQEQNYACLVTAAAAFRRLATPAGLELKASKLFLDICQFDGRALILFTSCNHKNTARNFYTFLNKLEHHQRAQDQSFFNLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYD3</accession>
    <name>A0A232EYD3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001651">
        <property type="protein sequence ID" value="OXU23319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYD3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="39" mass="4607" checksum="54AA47C65BAE5899" modified="2017-10-25" version="1" fragment="single">IVLFSTGQLAPERSEGAKRRVKLNYLSQEYRIKFYRADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYI7</accession>
    <name>A0A232EYI7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_003485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001621">
        <property type="protein sequence ID" value="OXU23403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYI7"/>
    <dbReference type="STRING" id="543379.A0A232EYI7"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU23403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="413" mass="48651" checksum="3D2426A60B934DA9" modified="2017-10-25" version="1">MKKTIFQECDKENQKAFDEAKTLISWNKYLMSALGLWPSHRYDFIFVSLFCYYIFHFLLDYAAFYFALRSFNLIKIIGVTMENVTMAQIFLRLYTMRRYNRQYGEILEEFTKDFSVKNYKSEEERNTFLSYNSRSKFFIKIVVIFLGVTAILYFTKPLIRQLSLSKNVNTTIAFTYDLPYRIHLLYKITDIQTYIATYISRIPILYIIGFTQTAMDCLTLTLIAHLCGQLGVLSIRISNLDVVNKSNELNEIIQRHQKLIKIGLRLRRMYRLCLLGHFLGATIAICILVYQVLISIAAGQKTNLVTFFVFGFLNIYRLYTHCWVGEYLIHEVMGFYMCKLCKLSFSINVSHAYYCCNWYKLPLRDQKSFIICIKRSQQPLSLMAGNFSHYSLVMFTNVMKSAMAYLSFLRNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYQ0</accession>
    <name>A0A232EYQ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001613">
        <property type="protein sequence ID" value="OXU23420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYQ0"/>
    <dbReference type="OrthoDB" id="7696725at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280172" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11858" checksum="3A44E57CC205E8FA" modified="2017-10-25" version="1">MFPKYCLTFCSFVLLAAVASSSQQVQSHEDKVKNVQNTELSKDSVEARNPALAIAVRILQQAFRWAAKHCLRQAANNCRQHWKNPKALVNCARGFLRANKGRCVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYZ3</accession>
    <name>A0A232EYZ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASX DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001538">
        <property type="protein sequence ID" value="OXU23652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYZ3"/>
    <dbReference type="STRING" id="543379.A0A232EYZ3"/>
    <dbReference type="OrthoDB" id="9348951at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035517">
        <property type="term" value="C:PR-DUB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF20">
        <property type="entry name" value="POLYCOMB PROTEIN ASX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASX DEUBAD" evidence="2">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="399" mass="45673" checksum="9A9A8A66F9C588AB" modified="2017-10-25" version="1">MEINTSVSKTMDAATSGLNNEFFARACQEWRKRLAEGEFTPENQQRLKLEAERDKNKLDPWKLKHFEPIWGEKRELHKFRSGIHCINKETKFLKSAAKCSGPQIDPNSNQILNADMSSETLLSRKVINKNVTYQSKHIANKANLVSSADDSVIPEFNVTVSILDDDDDDEDDDDIDIDDDDDDDDNDDDGDDDDDADDDEDDDDDEEDEDDEDDEDEEEDDEEDGDDEDDDDDDELDTRISLTYLNEEAQHCRAIIVSNTDNEQLYTEQKLSAEIPILEKTKYSKEMILDLINNSKYIDHDTKLKEDNRDKYLRNFEESPGRSTKSTSFANLKNAFTDDTIHQKSQSSMLESNNTDNLSVQASAQLFQNTASKLKFTIKDETFTSDIIVKVKTTESEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZF0</accession>
    <name>A0A232EZF0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_017070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001479">
        <property type="protein sequence ID" value="OXU23822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZF0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="118" mass="14099" checksum="6B3451B7B0C98D59" modified="2017-10-25" version="1" fragment="single">LLETTLILSTLGNRYLRDHCRRDIRVQRSQIPPSNEFRQIMSQFSIKLQETTLILSTLSTRYFRDPCRRDIRVQRPQKSLSSKTELISINIYRVANFLFIFFSNALLKCIFFMQKCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZI3</accession>
    <name>A0A232EZI3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001522">
        <property type="protein sequence ID" value="OXU23703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZI3"/>
    <dbReference type="STRING" id="543379.A0A232EZI3"/>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU23703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="288" mass="32683" checksum="C0AB5E24CB8EF3C5" modified="2017-10-25" version="1">MYVYLDLLPVNPSGEPAVQSERPGAALPPNDRDKVDQQRQQQHQQGPAAPPLEGQQSEEEEQRPVAPDSRSSLCRICRASSWTKEPLISPCRCKGTQAHVHLSCLERWLNQSCRNYCELCSFRYNALETPRYGWFAELSIIDGAEPFESLRIWVNHPRNRQHIRTDFLIFALLTVFTAGLSSVCLLGTHHFVHEGTRVGFSETWTRGFIAVFMAIVILGYSASVYYLIKYCISAAQTAKPKNPHTALQAHREYKSEARTHSESKQFLQANRVTAPADETFLIHRHFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0D5</accession>
    <name>A0A232F0D5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_016210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001393">
        <property type="protein sequence ID" value="OXU24134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F0D5"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MID" evidence="12">
        <location>
            <begin position="1359"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="11">
        <location>
            <begin position="1712"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="642"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="945"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1479"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1952"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="523"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1532"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1987"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2008"/>
            <end position="2019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU24134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2147" mass="232062" checksum="810A1291DDC3B953" modified="2017-10-25" version="1">MKKTDLCGIKWRKLVWGEVAGGFGGNLLEDPVLSSFSRCLQGDILCVWRRVSASQAQNAQMGNPFDINSIAPSPAPPPLSLQAAKELWIFWYGEEPDLTGLVSPELIACESEQGSWESGLSYECRSLLFKALHNLIERCLLSRDFVRLGKWFVQPYDGFEKHRCSSSHLSFSFAFFVHGESTVCASVDVRQHPAVRHLTRACLQRTQTSQSPVKVILAPYGLAGTLTGQVGRLDSQLLDEWKSFYPINSSCLEPGLPALVEVLVGGVRMRYPSCYVLVTDMDESPVMMSMTSGGSGCGAPAGLGPSSVTVNGVGIEITMPLSPPNSPASYEHPLSMQRDLGPATELPERVWAECIVGARASSPSQQAGKQLNNGETNEPNGGWNFVDPTFKSSCSCSKVSVSRPDAPKTPPDGGPPSYPRGGPPTGGDCLPVPSVGSPGSPAPSPLPTPHSEPPASIPPADAQNPAQQSIAGPAGALGSPQVQQQQQQQQSMSQTAINLLQPPLTPSQGGPKSIPPSNTQVLSPAIPSSVTSTSTPINPQQQQLQHQQQHQQQQQQQQQHPQQQVVQAPPPPSLKRPLLTSKEYEGALLDDEQPLPWLYDYSTQEAWLNHPVKRLKGTPLGPASLRHNQSLYPPMNPSSCAAAGQSNLLGENGPMGQAMQAQGQQPMLEIKQEPGTMSGECIGGRPDPYEFDANGEENGTGVDGLKRQRDEPKPSSLFTSEGLQASYKDLDQIFDNSDPDTSSDETNLNQLQVQTPPGSNKSGGGGGHDGSDVRLDSTTSNSGASGANTSSNSGKHSSSSSSSCNRGVGVLRPEELSKMFPTPPSLEHNPVASPCQLGDPSLEQTDLTSAAASAVAAASGTQIVQQHQQQQRQLQRQLPDIYPNMGSPPEEPIDDWSYVFKPPTMCKLVGSSKYAPLTNLPSQSLPPVTIPAHCVYRTSWQCSNANANQNNQDKSSQPTRPNSVQQQQQQQQQVLQQQQQQHQAQLMPASPAQLGTPYGRQQMQGGVMSVRPPPPPYDQPSPATSTTSSYLNKNLNSIEADTPGPMRAPESNSLVVNILLGDTALNIFRDHNFNSCSLCVCNSQGKGIGNIKGADAGTYLAGSWAASNNVFQDDDQFRCNCGFSAVVNRRLAHKAGLFYEDEMEITGIAEDPAEKKKASLATIACCDSKTVPEGIDIVPSTVLELLREQCLIVQSSASSLHKAARLYAANRTKPSSLSVNALEFSDSNELSLAAIDQSKLDGSPVDRSQRLNGVHRWAFLRAKGPQCNGDIVRIMKTVQPLLQEAIQQKATRMWDAPYTVRILTWRGFHRLAGRDTKDRCEPQPVPALVVGYDRDWLSLSPYALSYWEKLLLEPYAGPRDVAYVVVAPDNDCVVGKVKTFFRELSTTYEICRLGKHTPIAKTVRDGILRVGKSMTQKLANTNNVNNKQQQQQQTDEWFKLLGDNHLGECLRLYAQACNQRLAPYLTQVIQDRSLFDLGDMTGSGGKQNQSSSNVTETMPATPDGTPSKPESVEGENARSEAPSGATPNANSTAGNTTPTSQNTTNNPQTTMTGNSQQQQQQSQAAALGPDEEELELPSVVVYLVEPFSLGGADCPDRRRLAILALLRAFAAAMNNMPEGIRGNVSVQLISLESVMELGRVRERRKIQDEMRALALNVFLQGRRLLSHNTAARSLTGFGTAAAADLFLKNKDSHSNILAPAHQERNKAALRLYAPAYVLAPLRCKSEAPDSFGTTGPEECSVLYLSYCLSEDQSWLLAVATDDRGEIFETATINIDIPNRKRRKRASARRAGLQKLMDFILGVMSQGVQPWRLVVGRVGRIGHGELKGWSWLLSKKALLKASKHLKDICGQCNLLYPSAAPCVLSACLVSLEPDSNLRLMADQFTPDERFSQASVNCQLSTPQDVTCTHILVFPTSATTQSSQTAFHEQQINEPELGDDELFSALHEDLPEGMEGMTDFNDIFNVWPEPGGGGGQSPSGSPRRPEGSPLGGDGPGSGVGNHDGPGSPYPCSNTPRAANSEQVEESGNLLQQPLALGYLVSTAPTGRMPSWFWSACPHLEGVCPVFLKNALHLHSPAIQSNDELLNNQSAVISHGLDSTLTTDVLRYVLEGYNALSWLSVDANTKDRLSCLPVHMQALMQLYHATAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0W9</accession>
    <name>A0A232F0W9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein Abitram</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Actin-binding transcription modulator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein Simiate</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABITRAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001370">
        <property type="protein sequence ID" value="OXU24209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0W9"/>
    <dbReference type="STRING" id="543379.A0A232F0W9"/>
    <dbReference type="OrthoDB" id="48130at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000048">
        <property type="entry name" value="Protein Abitram"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="274" mass="31223" checksum="ED04D68FC8274366" modified="2017-10-25" version="1">MEVEETEIKSELYGAALKNDEPDTKKIKLSNEGDKSLIHQNHKDHQEDGQTISVEYEIPEKGFTYPLEMDASDMLDETDYDGYFPTVTERYLTPYYQLDAQKPGDDFCILIHSNRVCMITLAPSHPILQENKTIESCNYKVSEKLDRTKNKVSGKAKHGAQPLQSNSNLCSLTCTDGSIYAIKCCMIGKLIEVNERLVENPSLLKKEPHFGGYIAIILPNLKHLDSLKEKLLTQQQYEEAIQKRNELAEKSKEIKNERDIQEKVGGKEDIIKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1L3</accession>
    <name>A0A232F1L3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_003579</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001254">
        <property type="protein sequence ID" value="OXU24605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1L3"/>
    <dbReference type="STRING" id="543379.A0A232F1L3"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556718" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="21"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="77"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="342"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="676"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU24605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="898" mass="102714" checksum="33C15EF73F310488" modified="2017-10-25" version="1">MTLLWKLLILFAFATLATDAVDRNIFKTCQQSSFCRRCRQAVNAASSFAVRPWNITLGHSYVRAQLYHKKTNVNFTIELSATPDHSFRLRINERNPLKPRHQVRGVLNDEDRLALGQLKLVKHTDINFVVSSGPNRAYLQASPFKIDFYASNRRVLTVNAKGLMRFEHLRTKNSTNSGDGAELDPGAWEEEFRGHKDSKPLGPEAVALDFGFPEARYAYGLPEHADSLALKQTKAPAEPYRLYNLDVFRHEAYERMSLYGSIPLLYAHSEKSTAGVFWLNAAETWIDISALNNNNSLGDNSPPGVHAHFMSESGIIDVFCLLGPTPMDAFRQYTTLTGTGNLPPIFALGYHQSRWNYDNQSDVLQVSRGFDAHDMPLDVMWLDIEYTNGKRYFTWDPKNFSDPQTMVANLTAQGRKLVVIIDPHIKRDDQYFLHSDATKLGYYVKKRDGKDYEGESWPGPSSYLDLFNPKAREYYLSLYDFSKFKGTTKDVHIWNDMNEPSCQSGPEVTLPKDLVHYGGWEHRDVHNLYGLAQHSATYEGMLRRTEGKLRPFILTRSFFAGSQRFAAVWTGDNMAEWSHLKISYAECLSLAISGISFCGSDVTGFATEPSTELYVRWYQAGVWLPFFRQHSELTTKRREPWLLGEEVTTRVRDSLRLRYSYLPLWYTLFREHEIDGTPVIRPLWTHYPTEIDTFAIDDHLLLGDSILVRPVVEPNVSTVSVYFPGEGKVTWYDVYTQKAYSNGRVDIPVTLDRIPVYQRSGSVIPRKMKQRPSTVGMKDDPYTLDIVLDANKRARGSLYIDDQESFDYREGKFKHIEFDFKGGSLSSKFLYEGDFRTKSALEKIVIVNPPKDVSSAILFSEPNTLMNLRTEYSSDRDVLTLEGLNININKEWSIALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1Q2</accession>
    <name>A0A232F1Q2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001236">
        <property type="protein sequence ID" value="OXU24651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1Q2"/>
    <dbReference type="STRING" id="543379.A0A232F1Q2"/>
    <dbReference type="OrthoDB" id="7697912at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012827822" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="13301" checksum="86FD32E8D4DF5CE1" modified="2017-10-25" version="1">MSRRTVLLDMRPIVWLLLFATLATLARGFPAPQENEDSSGPLPFLQFTKGGIRVNFGGYHAQAGLGGLITGRRADGGLHASAGTPDGAHASAGLGGSLSDGPPVGNYSYCSSEAKKRTLPLSFVGNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F231</accession>
    <name>A0A232F231_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001261">
        <property type="protein sequence ID" value="OXU24580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F231"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17165" checksum="370848A08F54DC51" modified="2017-10-25" version="1">MTTMTRCSSVISSSKIRSAGMVPILFSSTLVTSLIMPRRRIRDLPDLVEDSDSDEGQHIDVAFIPNEYESSDGDSDCDPNEDTLSNELPSVSYEHVKSTYTSTQKLLEPNHKYSWKNDALNDISPHVESNFNISPISSLQSKNALELFEKKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2L5</accession>
    <name>A0A232F2L5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_001483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001222">
        <property type="protein sequence ID" value="OXU24693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2L5"/>
    <dbReference type="STRING" id="543379.A0A232F2L5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="702" mass="79500" checksum="41A5156C4F8D1EEA" modified="2017-10-25" version="1">MSDTMLDDNIQLDPIVDVDDQTKRSTSTSPRSRRKVCIYALFASVLVALIGLNIKFILLLISKNANDQNVDIWRSLVISDGKNLYALETDSETPSLLQASKNGIAAFDVYSNETVLWNEWQSSTIQSVSKSYRSIEGTEIWRMQAIAFDQANKLFYIIDKSAGTLSVFDARAGIHGIVFSDLVRAHDLALDPVTGLVFVLQQYDSILRCYMDGTSRREVIQDPSVSAFAIDRETRFIYYARKSKGISVTDYEGQREMRTVKVFVEILSLALSHNRLFWTSLPNSSDTSNSELWSCNIAQVRCYNATRREISLRNPRVIKASAILRPFDNPCDDNADCDQLCLLSSNSSYSCACNMGWYLNPSSGTCEETISTLTYVQGNFIRAKHPNNLLKPFSDNMLPRSFYTETLIRKSSIDYTYGIDSFYISDDTAIYRLNKSSEAIDGDQKKIFSVGEGSLIRNIDFEVLNEYLYYVDESSTGERSIAALSLVAGEPARKSKVKSQVDVFLIGAFYSLIYSPNWDEIFGPQSLPNDHFSKKSRLRYFNMHELVSLDPSGDRLCWISNTSVTKIEYLHFNAVESKYFDRGVMDLPIMINPMSLAIGFDWIFIANFTGIWRFDRLDGHGAAQIAGYLGRDEKQMVSHAKIEFETPDVAESTVHVMCESFEEKRSRYEKLEALQRWYLIGASAVIAILLITLLIVAAVWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Q9</accession>
    <name>A0A232F2Q9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001174">
        <property type="protein sequence ID" value="OXU24872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2Q9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044179">
        <property type="term" value="P:hemolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027018">
        <property type="entry name" value="Hemolysin_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06109">
        <property type="entry name" value="HlyE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="158" mass="17775" checksum="4795BB311571772A" modified="2017-10-25" version="1">MNAIVESQKARQALIIAGVISLIFIMLDLLRVFVPLGLDEVIRRQRQATLFKRSSIFSMKKLINASTIATQVDVDLEEDKNNLYVLSGLVSPADRNKKMLLMDSPIMRARLVPSFRNAWGTNVKTNTPCGTGMARKNTNIQDTRESDVMPPKRVKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3L2</accession>
    <name>A0A232F3L2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_011075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001131">
        <property type="protein sequence ID" value="OXU25033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F3L2"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001366">
        <property type="entry name" value="ATP binding protein, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000742">
        <property type="entry name" value="NFX1-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="10">
        <location>
            <begin position="1782"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="domain" description="RZ-type" evidence="10">
        <location>
            <begin position="5209"/>
            <end position="5287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3518"/>
            <end position="3600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2658"/>
            <end position="2685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="4336"/>
            <end position="4363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="3563"/>
            <end position="3575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="5294" mass="612970" checksum="44B76A7CA606EC5E" modified="2017-10-25" version="1">[encoded data, 5294 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3P0</accession>
    <name>A0A232F3P0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001120">
        <property type="protein sequence ID" value="OXU25063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3P0"/>
    <dbReference type="STRING" id="543379.A0A232F3P0"/>
    <dbReference type="OrthoDB" id="427950at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="283" mass="32893" checksum="8429C8D64A9F3F2F" modified="2017-10-25" version="1">MATVLMRMGLRPAIVGKSLLERKLASSICSSFLENNEFASDATHRSLAQTSPKFQHFAVRQMSSKRNVHHTRTSASLDEKHDDDDSDFDSDSDSDDEKSRKEPSRTESHFWRRKMRTLHSHLDVNKDGVLSYDDFMLLGERFAKMGHLTAEQKVEFQKVLSQMWEEQWGEISPYNFVDVEKYLAEMHHVLEDESLRRKVHHFLPYLFKAVDKDNSGEISVEEFKLFFKCLGLGNDDAVVSFTFIDTNEDGKISLKEFVKLGRDFFLTQDHHRPSKHFWGPLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3W6</accession>
    <name>A0A232F3W6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001092">
        <property type="protein sequence ID" value="OXU25160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="210" mass="23690" checksum="9C17E581387EF420" modified="2017-10-25" version="1" fragment="single">VHLTRDEGTFGDTSISDDDTEKSTDSEENDCDVHLTRDEGTVGDTSISDDDTEKSTDSEDYNDCDVFQSSLFKMSNLNDFMIHEKFLQTISTPVHLTRDEGTVGDTSISDDDTEKSTDSEENDCDVFQRSLFKMSNLNDFVIHEKFLQTTSTPVNKSPGELFIMLIEFTLSHKLPLNAISSLFHLINTMFTEQILPETSYLLDKLLNXCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4D5</accession>
    <name>A0A232F4D5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein polybromo-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_015577</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001049">
        <property type="protein sequence ID" value="OXU25338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F4D5"/>
    <dbReference type="OrthoDB" id="10009055at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05524">
        <property type="entry name" value="Bromo_polybromo_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05517">
        <property type="entry name" value="Bromo_polybromo_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05520">
        <property type="entry name" value="Bromo_polybromo_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05526">
        <property type="entry name" value="Bromo_polybromo_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21984">
        <property type="entry name" value="HMG-box_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000045">
        <property type="entry name" value="protein polybromo-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000009">
        <property type="entry name" value="Protein polybromo-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="362"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="506"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="640"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="14">
        <location>
            <begin position="935"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="14">
        <location>
            <begin position="1129"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="13">
        <location>
            <begin position="1348"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="895"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1318"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1077"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1324"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU25338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1638" mass="187568" checksum="3F67EF0B2406ACCA" modified="2017-10-25" version="1">MNKRRRTSSVASRGTEDDPDDIIPEPTKRRKKMDPSDLCLQLYDLLRNHRKEDGSLLCDSFIRVPKRRQEPGYYEVVSNPMDLLKVQQKIRTDEYRDMDEMANDILLMVKNAKAFYNRTSQEYKDATELWDLCVSTKTRIMDEYEDEPSKGKLVLKTKRTITRQDDAEDTSESSTNPDDDIQAYEDLFAAVMLATDPSDSDRPLHLPFLLKPSKKLYPEYYEVIDQPIDLKTIAIKVQENVYNNIAEMERDLMLMCRNACNFNEPGSWIYKDAKLLKKIISTAAKKQTNDVTGPVLKSMSAALSTRSKRGNRSAHALIAQSAALRDEDEESDDEEEDPLDTEESDNPQWQLFQTIRTAPNSTGLRMSEFFWTLPSRQLYADYYKTIKNPISLLQIRKKIKRGEYGTVSEVAGDMNLVFENAKKYNVHNSRLYKFAVKLQKVMQEKVQELLEFDQESESEDEPDNAHPKLIKRASNILTRGKYKDNIPLKKRLHKLVKCVIEYITDDGRQPILMFMEKPSKKLYPDYYQVIAEPIDMLTIEANIKAEKYHTENELIQDFKLMFRNCRQYNEVGSSIYDDAKTLEKVLMDKIKELGPLPEPVKPNKLTTPTRNVGRPRKVVPLHLQKMRTMYDTIKDYHDAKGRQLSSIFMKLPNVKEYPDYYENNGYDTLDDLVSDLLLMFDNACKYNEPDSQIYKYYINKIANLPYVSIDIQKWRQRYKMATVVIRHFEVTSDALILQRLVLQTKLQLSEDEESVPDVAAAVQEILASIFTALYNHQDEEGRCYSDSMAELPEHDIVDGKKVRGLSLDLIKRRLDKGVYKRLDRFQEDVFSCLERARKLSRTDSQPFEDSVELQAFFLRTRDEVTRNGDLLHSSALNYTLHDLANQVAELKRIKVQQEPSSSNDDESCDGNDKEADTSNSATNSDNGGFMSFNQETYRAGDFAYIEPTERGMETSIVLIERLWTNAEGQQMLYGNLFYRPSETYHVASRKFLDKELFKSDAHVAVPLAKVAGRCCVLSVKDYFRMVPEGFSEKDVYVCESRYSTKARAFKKIKVWNFDPDHLKLSPRDKPLEPKRVISVYKERLEKHKEEIAELEEGEKLIEKEKPNVILFNADDPDNTYYEQYNTCVGPVKLGDFVYTATDGGRQQITQIDSIWSTKEGPWLLGPTEITHAPSKLFYKQELFLSTVDATHPIVAIVGKCAVLDYGEYICSRPTEIPEDDIFICESAFDENKNMIRKLGAEGLKKFNHSNQVTEDEIYFFRKPINPAKVPIDVPQTQNQSKSIGASPSQFETEASPYFSKLDVLGSDGIGIGVGEDSLDAPPSVGSTEAQPVLSNSHTPVSSKKKVPGRKLVTGYILYASKMRTTVTQNNPDSTFGEISRMVGNEWRKLPPTEKSLWEERANKLNEECQTRLQAGSMQDLVYECCWENCDWQFEDMADCIEHSVADQTGHIQTFFANSNNDLEYQCQWRGCGRMKKSVPPFPSVQRLARHVKEVHILKSNGRAIPPADRSKNFVPSKGSTTLAPMETETSAAATQTNNAAPAKQPEPLFVAVPPRPSRVLHSDAYVRYIEGLTAENRYISNWDKQMSASPENTQIPEVTKLPADWLGNGVGNHGNVVNALWTLRNMMMRDVLAINKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4W8</accession>
    <name>A0A232F4W8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_000218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001003">
        <property type="protein sequence ID" value="OXU25528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4W8"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="324" mass="37651" checksum="77CF4F2C573D0A4C" modified="2017-10-25" version="1">MNSKVLFMILKNWKISDLLFFKCVFYLFKLFGLATTSIQTKPSTSRFYLPLLTRSKLGQIYNVILAIGISLVYACLIRWTIKHYEHHIISRSHQAIDYTHTTMAMITAIFVLLVFCMQQEKFLNLGNRTVRLGELLVGFYEVQRPSKQKTLTKHVKEIYIMVGMTWLSIFATTETGGYFKNVVYFSMIYLCNQIITLTLLQYSAILRCLQQILWIVNENFLQFSKEPCQMDKIKIQFSKLRELYLSVCEIAEDIERFYAKPILLCIVYVFVTLIFFASFITKPMVSAVVISDFQICHCSFRILHYVVALIILVKSVTAAVSEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5G2</accession>
    <name>A0A232F5G2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000965">
        <property type="protein sequence ID" value="OXU25703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5G2"/>
    <dbReference type="OrthoDB" id="7694761at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15979" checksum="87D0006B146DA0FB" modified="2017-10-25" version="1">MIGPIYAAPIQTCCDRSTVPIVKPIRIFQFILVTLLFALTCHTVSKDSPYGQTEAAAIWALFATFLLITLVDIVSQCGSDPIPDTPMFLFGVLGTLFFLMAAGDILIASRKNGITGIWRLMLAVILSITCALLFLLDVLLIFLYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5I9</accession>
    <name>A0A232F5I9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000886">
        <property type="protein sequence ID" value="OXU26061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5I9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="9734" checksum="EE5C4B38AFA680EC" modified="2017-10-25" version="1">MMMMSQSRQVLIGWMDLGPEICPQKPMASDAQLKTKKKDICWGCNVLVRRLLRIVQESLAEGLRSEKVTLGNGFDDVDVAEADDPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5J0</accession>
    <name>A0A232F5J0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000953">
        <property type="protein sequence ID" value="OXU25748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5J0"/>
    <dbReference type="STRING" id="543379.A0A232F5J0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="485" mass="55871" checksum="84D87F583D94A313" modified="2017-10-25" version="1" fragment="single">MQLFFSNIFSNETLTVNVRWIAVLYFKNGVDKYWRKNAPGEIAADEKAYLRQGLISNFNEPVNQLSVQLAVIIGKIARYDCPKEWASLVPTLLEVIKDNNSLRQHRALLTFHHVVKALASKRLATDQRLFQELTVNVFTYILNIWNTYTESFFALLSRGVSDNDVQDSIEKALLSLRILRKLIIYGIKRPSENANAMIFLKLIFERANVSLNCNFDLYCGKNSTIGDKLAKCALGTRVVMNLLDNFFSTLTFRKVGLYHLYMDNYFTSLDLFVHLRKMGLRSTGTIRENRIKEKNYIDKKSTRGTYATKHDQKSGMNLITIIDSKPISIISTASGVTPLLPSKRYSKEVKSKIDIPFPNAFHLYNRFMGGVDVHDGHCNDVMPCIRSKKWTWVITSGRCHQCRRSLLSKICEKFIIHLTKVLLEVQEIHPFCYIDMIPISLEFTVYYCFTEAGQELSFERFNIQCLNLIKKILQSNDYKPGKAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5M9</accession>
    <name>A0A232F5M9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4812 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000907">
        <property type="protein sequence ID" value="OXU25975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5M9"/>
    <dbReference type="STRING" id="543379.A0A232F5M9"/>
    <dbReference type="OrthoDB" id="521617at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032084">
        <property type="entry name" value="DUF4812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16071">
        <property type="entry name" value="DUF4812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4812" evidence="1">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="376" mass="41714" checksum="89D7AE1FF4775460" modified="2017-10-25" version="1">MQRKCCAHCPGSVTRTGDPIREHVCTVPEYVGGSLRVSSLSGRHVCKNGRTKSAKGTEMPEPTGSCFDRFATAKKFHAENLQHQPLPDKVDDAIFTKDKKAEDPCMCEAVKRCQKIVPRRQQNRKKEINRVHKYAPALGCKKPMTYMDLAICWETPVDPSYEPARPAHIDGSDGGPAPAIFALVQHAESQTDCKDGCIPGMRGVEDGEECEHHQPCDKCCQNGINSAIEANDDLCKNLDSLHITSPRNSKPGVGAAARCKRAHFLRHCVACCSKSEPKKSGRARSASCLQKNGCTVVARKNNGLPGKANVPRPRTPYARRSFCIDTLAPPFSIVTGCRDADYPEHWRLTSIYQQSYRNPRKMREGRTILSYDRSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F631</accession>
    <name>A0A232F631_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000829">
        <property type="protein sequence ID" value="OXU26294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F631"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26983" checksum="914AE865421722D2" modified="2017-10-25" version="1" fragment="single">EDWGFNYHLSEDRKIDRTIFEKVVKLCGLHITRIDFSKYYDYGRKQLTANKSPFKSIEMFCPNLTAIDIRAVTVTLQGLECLAKSCLIDTCDYLNFPNVIVEPLSLFFKNNQNLRRVIFHVLYAENCLHAYSVGGIEVTSIMRLPKIRELCLCDLEDITDLIFFDCASPLKISRCSQCPGLRNFGSLQLVQSSTENLQILVITDCENTDLEELIQVAGTDNRIKSESGCCAPSELTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6J8</accession>
    <name>A0A232F6J8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 184B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000884">
        <property type="protein sequence ID" value="OXU26068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6J8"/>
    <dbReference type="STRING" id="543379.A0A232F6J8"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48706" checksum="E0FE8B3FA2B07F21" modified="2017-10-25" version="1">MSSESPMDVLSSAASIINATAMGSMPANVRVDDPNKEVTPIFLQTQAAKGIAGAFVWAALFISCQQIYQHLRWYTNTAEQRWIVRILFIVPIYATYSWISLLFFNNESYYVYFFTVRDCYEAFVIYNFLSLCYEYLGGEGNIMSEIRGKPIRSSCIYGTYCLAGKTYTIGFLRFCKQATLQFCLVKPLMAFVIIFLQAFGHYRDGDWSPDGGYVYITCIYNISVTLALYGLFLFYFATKDLLTPFDPVLKFCTVKSVIFLSFWQGVLLAVLEKANVISPVIDSLGHSTSAGTVSAGYQNFLICIEMLFAAIALRYAFPYQVYAAGCTTDSRGRSVTMQSISSSLKETMNPKDIMTDAIHNFHPQYQQYTQYSSGGGAKSQRGMRVSSFDPEDPQNMPVPPPQRRNVPNQRVATISQNYNEKTMLLSSDDEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F704</accession>
    <name>A0A232F704_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000762">
        <property type="protein sequence ID" value="OXU26636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F704"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="119" mass="13778" checksum="C89C57F3A57D1989" modified="2017-10-25" version="1">MNVSFWSFHGYGAILKIIPRDDVDTVYPGHQVPTKPLSSLYSYSVTSKTPNQRVSTKNVTTLILHTLGTRYLGERCRRYSRVHQPRKPPSNEFRLIMFKILTKLEETTLILSTLGTRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F883</accession>
    <name>A0A232F883_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin NUP42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleoporin-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_008597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000676">
        <property type="protein sequence ID" value="OXU27056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F883"/>
    <dbReference type="STRING" id="543379.A0A232F883"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU27056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="688" mass="68611" checksum="5AFD2B0CE768817F" modified="2017-10-25" version="1">MVLCKYFQQGTCRFGQYCKFEHAYGNRSKTFGDEKNIALLVAEDVLQAERGGQWLLSCYGPFKERKCIPGMDDLSPEEVRWEMYQAQKTGAVDQIKAQFQQMCEAMKVKRDALKNPTPAIVQLLEEVQSSGSENSAFGDKQKQGNYAFGQPQMEASNQPNQSSNVFGQKPAFGAAPSNPFGGGTNNTFGSNQQSSSIFGRPAAATTTNSVFGGKASFGTPSVFSGGTATAAPTAGGSIFGGGSKPAATPFGTVQNAPTFGGLATQGTNIFGGAATGTQSGFGQPPAFGAAQAQTAAGNAFLKPSTAQGSVFGGAATGGSVFGGNAAATAAAPAFGATPAAVSSAPSGTGIFGQPTQANAAFGGAPVFGGTAGFGAAQPTAGGSVFGGQSAFGAAPAAAASTNVFGGNTAAAATTGFGALAQQGATANAFGAASATPAVATNTFGAASATPAATNVFGAPAATPAAATNAFGVASATPAAATNAFGAAPISTTTGPFGGTANQADIEDKSMILNHRIAANTVFATSASAAPGPFGGNAAFSKPASFGFATPATNTTSVFGTSTATSTTQSPFGTNTFGNVQPQQQQQQQQSVFASSKQTTAAAANPFMQAKTQQQSSPFGVAPSTQSSPFGNFAKPTGNAFGSVSVTVMIDETAYSTDDCLTDDEKAAYRASAFTEGHIPLRPPTKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F930</accession>
    <name>A0A232F930_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000692">
        <property type="protein sequence ID" value="OXU26953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F930"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19743" checksum="041A6CA1BD8C29AB" modified="2017-10-25" version="1" fragment="single">SDPGYQFARYHPYHITLNQDLNEQGRQQRVQFCQWARNQIRNEQIFFQFVMFSDESTFNSIGNVNSESYLNLIENELPNVLEHVDMNTRYRMWLQQDGAQPHYARIGYLKDTVYRERPTTANDMRMRIKDACANIPHNVLIRTVGHLQQRLQLCLHVGGATFEHLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9H0</accession>
    <name>A0A232F9H0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000669">
        <property type="protein sequence ID" value="OXU27083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9H0"/>
    <dbReference type="STRING" id="543379.A0A232F9H0"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02638">
        <property type="entry name" value="R3H_unknown_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039884">
        <property type="entry name" value="R3HC1/R3HCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678:SF0">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678">
        <property type="entry name" value="GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="614" mass="68697" checksum="8697F2C470ED9E09" modified="2017-10-25" version="1">MSLQDNLFAEDAEEDLQLFLKSDKRRRVLLFPPVNNYRRFLIHQLVQDNFGDLLQTFSIGQGYARRTVVCYKSDFIGLPQVNGVSSQATNNGTGKSSDRMGIESQCTPTASPEHSANKSRQVKSTPAYEIYRPPAARRARLEKSPARPASTEPTQMSSDASARANRQKRPDRAVYVPRHRRGAAEVDVPPQDPPTPPKPSKESSRSTPKPTTIEKMQTDPQPSVPKEMPAAVTPAPETIIEKIDDYDETEKADQEIPKETPPANDLPDERMEEDVVTKSEVPLEPVSTPEAPKEEAKPEIAESLVCLDESDKRDRRKSDEIVREPVNESAQKRDEAIRNRRNDNKAVKKALISPVLIISTKEEEEKEAKKSPAPVFPVVAMTPPEKKVKKVERPKSKPAPPPAPPVKINRDEADWDSLFDDNGDCLDPTLIEELSSAVGEVVIEKPKSKSFTRPVEVSNDEYGHVLEIYNFPSEFKSSDLVAVFSPFKSNGFELKWVDETHCLGVFSSPLVAAEVLASDHPFVKTRPLSEATALSKSKARRSSEFLQPYRTRPETCAALARRLVTKSLGVTLATARQEREQEKILLREAKEKKRLANKQREDVWEGIIAEKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9P6</accession>
    <name>A0A232F9P6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000657">
        <property type="protein sequence ID" value="OXU27153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9P6"/>
    <dbReference type="STRING" id="543379.A0A232F9P6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="924" mass="106497" checksum="3211B506F5362460" modified="2017-10-25" version="1">MVGEVIIDWSEKDNLVLSLIVYTGTERINKPEIEDCATKTDTNFFITDVRSIDLEDHFGSEKAIQVCCFHCDKAKRVFGKRISKCDECGTILGFKCLKCFRERTLKTCEHASMRCTISGRHLSYEFLREKRAILERNKENRERFYADRANSVRENLLELRAEFEGEIPPVKRKKRGSAQASKKGNNGKNIRGETLFNSSGMILLLCTACNTSKPKINSQKETHCKQCGTEFRFQCITCSSSYTTHTSCNQHIKYKHLETSDSFTGSDFQVKYEDFVNGLKVTNNSEKKCWQKQRKLEGERDPQSAYYFRYMSDNSDCKIKTNEKASLNPYLYYCRECHSSYKRYHGYSISNCPNCKTKLMYRCAKCISLRQSKRSIKRHIFYCRQSSINKREEDSEIESENSDSSSHSAKIRTYIRRSSEQFSSKNLVILFCPSCEKSTPKIHGVKTNKCKDCREVLLFVCKKYVDIGEIFLTASPLDSLYEFQSTISPDNQEQANLKNLPAKPPDESQSQKAKRISKPKRRRNQHKHTLEHSLKIHCPGCQNGVELENTLYENGRPQRCAKCRKKVEFLCLWCEGIFRNYQSAQYHCNYTCKKQPPVKLVFKHVTVGLEKLKLDIVDEDIIINEDEKEIGFTEVFSSAKSKGLAKGLKPAFYIEEPSNLTISKEEGVYAKELSPEIQLITIDSDDGFADDKNEDKLSLAECVVCNIDPDRKASKHDSSKRRVCGKILGGTSMQKIDQVSQVKMKARLRCSCCFDDVDINRSAVNFYSKTNCKKCKAPLLFVCNFCQNSCSNLTSMYKHLKITCKTDSVTFLCAKCPYTTKYKAALKKHVETRHISRKCRKCGKIFNDARRMSVHERYHCPVEINNTILTFVCKLCDRKFKDLSSLVDLDHRIFCVKGFHCDICGYVTKFKGDIRKHIENMHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9R8</accession>
    <name>A0A232F9R8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial glutamate carrier 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glutamate/H(+) symporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Solute carrier family 25 member 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_003760</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamate(in) + H(+)(in) = L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000606">
        <property type="protein sequence ID" value="OXU27415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9R8"/>
    <dbReference type="STRING" id="543379.A0A232F9R8"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000026">
        <property type="entry name" value="Putative mitochondrial glutamate carrier 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF5">
        <property type="entry name" value="AT03939P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GRIP" evidence="20">
        <location>
            <begin position="680"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="790"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="889"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="999"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="550"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="67"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="304"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="636"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU27415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1094" mass="123059" checksum="283B8B5ACA290C6D" modified="2017-10-25" version="1">MMEESVLMTTSTTIQNEEESMSSGITAESENTAAGDGNENKSIVDKTNNEDGNSNIEERYNKLRGFAVKLKKKVSDLTDQTKLLETENQKLSNEKDELQSKILRMSEGAKKLQTIQSQYDKLQDDVELVKNENKRLTKKLENLVLENDSLKDTITKERREVTQLSAKVSSLSEEKTKLTTACEQFEKKVKDLNNELKAELLVRQQKTKECEDIKNSLDAEIKAHKATRARLDDMKHDRTSNNVLSLEVANYEKSIDTIKSKLDEEVNERINLESTVSQHLETIEVLNVRISELQDSCLAKTNRITTLEEKNLTLESDARNAKLEASRALKEKESLTRESRRLETSKKDLEAKVELLTSEMAKLEEENRSRIKAFQSHVDDLKRETSRLNLALENSKRETGTLQEEFENYKLRAQSVLLRSKNVPSSELEEEVEHCKRQISLLTEKCEGYQERTESLMREIILLKDERSRSAASEEELVSKLAMLRQDSLALMEKYKNQEAEMHRLHIVHEKTIDDLRRTYEEEINNLKKRHEEELQNVKLEATLNSRITSQSTISMTGPPVLPPASSPPLIEREECEGSESIDSLQQSSKNSERSQGRTIAPETPITTLTPLDQLLEFPFDEHEVVSRVPEDSPEVVVYKNRVKHLTELLADAERDIAKLTQLNQLLKEDIRRQKRYVEREKEAVNFEYLKNVVFKFVTLENRDERSRLVPVLDTILKLSPEETHKLEEIVSATGGAACTELLTEHFQENHQAHARSNFVVSLLLYKRPDCRCSKMSQAQQQQLQTAGQFKLVPKIINGGIAGIIGVSVVFPLDLVKTRLQNQVVGPNGERMYSSMLDCFKRTYKAEGYLGMYKGSAVNILLITPEKAIKLTANDTFRHYLSTGPGEPLPLLREMLAGGSAGACQIVVTTPMELLKIQMQDAGRVAAAAAAKVKSEGGAPPKKASALALTRELLQKRGILGLYQGTGATGLRDITFSVIYFPLFARLNDLGPKRPDGSSVFWCSFLSGCAAGSTAALMVNPFDVVKTRLQAINKAPGEPTYDGVIDCIGKTLKNEGPTAFFKGGACRMIVIAPLFGIAQTVYYLGVAEKLMGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAY2</accession>
    <name>A0A232FAY2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000576">
        <property type="protein sequence ID" value="OXU27593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAY2"/>
    <dbReference type="SMR" id="A0A232FAY2"/>
    <dbReference type="STRING" id="543379.A0A232FAY2"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13288">
        <property type="entry name" value="PH_Ses"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000378">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF53">
        <property type="entry name" value="INOSITOL PHOSPHATASE INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="215" mass="24919" checksum="7080A245D32E6C0B" modified="2017-10-25" version="1">MKCNEKNMIAFATSSTPVDREGWLNKRGEVNRGYQRRWFVLKGNILFYFDRRGDKEPVGMIVLEGCTIELAEDEEQFGFKIVFHGPNNRSYILGAESQESMEQWMKALACASYDYMKLMVAELQRQLDAAEEETTVTPPAELPKPPPRQRHNPFNRPESHHRSQSVRSAPGRTENIPRTKVSFKDIHNMYGRKILADLNKWRHAKRNSEAPLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBG9</accession>
    <name>A0A232FBG9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPATCH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000540">
        <property type="protein sequence ID" value="OXU27798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBG9"/>
    <dbReference type="STRING" id="543379.A0A232FBG9"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="873"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="904" mass="102625" checksum="B5DD1792F3FD4E3C" modified="2017-10-25" version="1">MSDEEDDFVTYGNALDPLDEENLPRKKAVTIEEQFAYDDQGRRRFHGAFTGGFSAGYFNTVGSRDGWRPQQFKSTRANKAGGVVQRPEDFMDEEDTGQFGIAPTAIRATQEYSDETHKGKKRERAKQDSSGPIPGTPVLRELLKPVRERAGVMLLKKMGWRPGQGVGPRLTKKEKKHQSQQRENIKVYGCSLPSQQSKYSESESGSSDDEFADVTFAPDDYEPFRCNPKDNYFGIGYSGLDRRPVLGQHINLFEAPSFSVQDKNKKLSIKGQAFGVGAFEAEDDDIYARDDMSRYDFALGPERKAKSRWSKKDEPKHSCIEGFVPAKQQLSQKKVFIAPTLPKDFNPVHKVRKSRFSPLAEEQSNVRKRYEMNAESRAKIINDDRPSIIDSKKAEPKNTSVAAKLISRTLNLHGKEQTAERQKLEQSQTKKSAMSWLDKLSATTFVKGETMGLDPKIQGNLQSASAFESGQENKDQELSEDTNLTRPSFADLDKQRRFEQFLSFSEGERKLKFSSVQPLSMTEWERDQEVEEFEKAAALCERIDKARKNADEKTEEQKKLEAKVDLESLKPEDRMTAAAKMKMYGKLTRTDEEWKPAKLVCVRFNIAEPSVGVAEDDKKKKKFSIFDSIAWNEVSKFEAGRKLEYECEPGPSTSSGISHEEESDYGIEQSSSEPRPRLTEKEKAFEESYKKVFKKVEETKEKEDEIVEAKEAEPEEPVAVSSNIKEKKDLYKSIFLSSSEDEESEGEESKLVDEEKLKAALIGKSAAEMNAQRNTSPPRGIFANVDFDSLMKRPDKAETQKDKVKEVDEKKVEEDEVVQVKMEEDHLPPDVYGPALPTAIPPVEEAAKPVFTGGLSRKSSDGDDGKWVEKSRDKKKSKKEKKKHKHKDRSRSKSRKKSKKEKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBZ5</accession>
    <name>A0A232FBZ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_015854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000494">
        <property type="protein sequence ID" value="OXU28010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBZ5"/>
    <dbReference type="STRING" id="543379.A0A232FBZ5"/>
    <dbReference type="OrthoDB" id="10067323at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361:SF1">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="527" mass="59861" checksum="A53774FD491D6B1C" modified="2017-10-25" version="1">MGRRSINTTKSGKYMNPTDQARKEARKKELKKNKRQRQLVRAAVLKGKDPSQIIEEMEKIDQMEYNVMQPPPLNEKVLKDKRKKLKETLDRVLKMFAKDDQEKWTELKDQMIQYERRRLELVSYFEAVRHAQQVQVDEIPLPSSGNQVYTGPMTAQIPLPEMPPMHSYPPHSHYYSQHHPLANIPVPPSILKKTSIYSSVNNSTMMPTNRDPPGVPPFPPPDIFLSDDEDDDRMKLSHKSKTIRFADEDRMDDDKREDMDGKEIDKDKEKDAAKKPTSLQQKMLVMAGQDIEQFMKEMEVVHKKRETERAQDLNARLSLLDGDSVNQDQNDKNTIDVPAMPAPQPPMPLMGLPPPPPLMYRPSAPPLHLRIPPPPPPRHSMGIRLPPGPPPGMPRMMRPGGPMPMPRVMGPMGPTGISGVPNAQKTPNVLTAAPQLINAKKDKESGKTTIEAKPQIRNLAADVTRFLPTSLRVKRIDDKKKPSVPTPIIRIPERMPPEPPSVPKPVQQPKTKDDAYMQFMAEMKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCC2</accession>
    <name>A0A232FCC2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_006706</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000472">
        <property type="protein sequence ID" value="OXU28140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCC2"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="515"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU28140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="672" mass="74533" checksum="A4DF7BE45A514ABD" modified="2017-10-25" version="1" fragment="single">MELQAKKPHGSCNSALGMESGAIADSALNASSSYVTTVGPRYARLRKEAAGGAWCPKRQIESGIREWILIDLGTTHLITAIETQGRYDHGRGQEYTENYAVEYWRPGFSEWKQYKLWDGTEVLAGNVDTSTVPNNSGHKYKLQRTSCVSVAGGVVSYTIPESPVAELNDTSYDGVREYGVLSAGLGRLIDGETGADNYKQDIADGRGTGWVAWMRDSFPDKYVELTFHFDGIRIFDAVHIYTNNYFTRDVQVFAKADVWFSSSGEIDEAAEPLSYTYIPDTNLENARNVSIALHGRQGKVLRFRLYFAARWIIISEVTFDSWNPYANATEETASEISNEDGSGVEAGSVLVATGPVNHDADLNLQTITAREEGQEYVEVLIGVLTAITLLLLLVFIIILLLSRRQKLQSSPTVLKNPFGFAINMKGFLLNLAPGRMLNDSGRDSPDLADEEEPDGPDDEEEEDVDVELDGLDDGAANLVPPDDLSMRESLTMEHFNSPLVESQYKSTYAIVANTDSPSRELQQRREELRSSKSFEKGYNSGSSRQQDSCSLTLAGSSRSCSPVSSAHYSPSTRHSQHYRTLQGHAARLGSASREHQQQQQQQQQQQREPDYTHVKRWNTAPKEKHKVPAPLVKWNIAPSMGKPYKCKEIEPANIPGQCLHTMEKLGSGHIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDA7</accession>
    <name>A0A232FDA7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000399">
        <property type="protein sequence ID" value="OXU28655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDA7"/>
    <dbReference type="OrthoDB" id="7697747at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="14715" checksum="8362C2B79F911393" modified="2017-10-25" version="1">MDDSVINESIVTMKLDAIELSERRPQRSSSANAIKALEQKLRKFFNEADGHGSLHRKPPPNMITPQYFKVVNTISCYPIKRMDWIALVNSANFKRKFTIVDDSTKTQRPNAIVCGKDNDKPHPSSPSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDI6</accession>
    <name>A0A232FDI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_016699</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01000422">
        <property type="protein sequence ID" value="OXU28509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDI6"/>
    <dbReference type="STRING" id="543379.A0A232FDI6"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18018">
        <property type="entry name" value="DEXHc_RecQ4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000772">
        <property type="entry name" value="ATP-dependent DNA helicase Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511538" description="DNA 3'-5' helicase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="65"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="265"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="827" mass="92961" checksum="1354CE291942CA61" modified="2017-10-25" version="1">MRTNALTFTRVLSTSLWGLASATRERVRAFSAVACGNRSDAPSEVLTALAKFGHKQFRDGQEISIMRTLSGLPTLVTLTTGSGKSLCYQLPAYLYAQRSKCITLVISPLVSLMDDQISEMPDFLPAACLHTNQSPMLHASILNDLKAGKITILLVSPEALGACDTSKSYVTIFRDLPPIAFACIDEAHCISQWSHNFRPSYLMLCKILREHLNVKNILALTATASKYTVSSIIDLLQIKDEKTGVISDKPLPSNLNLTISHDKKKEDALISLLQSERFIQYNSIIIYCTRREECSRIAGLLRICLKDQNFKLNHSKRNEKNKSAIAEAYHAGLSAYRRKSVYTAFMKSKIRIIVATVAFGMGINKPDIRSVIHYNMPSNFESYVQEIGRAGRDGSPAHCHLFLNAQEAGSSAVPRPSSNSLMLQVHGLCPMTTCSKTSANKTFVAKEFIAFKCVNPFDINTGHSKSLRKISKEFQNENSDECELRRHINADGIDRRTIRRLLKKIFIPCNCKNLSKADTKSRCQGHEVAFSVEDTVTSLDIKQETVATLLCYLELYFQCFVKLLPTTYINARIHSYDGLKDLISTVVYSPSLAMAIALLTEKGIYQDSLSTIEFPVIHISSLIGLDSGLLKNQLKRLEWKKVNGEWKRSTISVNFDTLGFRVKASGDLTAQELDKILDSLTQRSALQVTHRLKQLENISSTLRKYSNSSIKDCLKLTCENYEKSEKLKDAIRTYFESDTLGVLCDSVQLTTNKLDEEEQVTNDIRNLISSYKDINFTGRSIARIFHGIQSPNYPALIWSRSRFWRIHINKDFNIISQLATKEILKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDK2</accession>
    <name>A0A232FDK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Low molecular weight phosphotyrosine protein phosphatase</fullName>
            <shortName evidence="7">LMW-PTP</shortName>
            <shortName evidence="7">LMW-PTPase</shortName>
            <ecNumber evidence="7">3.1.3.2</ecNumber>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Low molecular weight cytosolic acid phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="7"/>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000364">
        <property type="protein sequence ID" value="OXU28866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDK2"/>
    <dbReference type="STRING" id="543379.A0A232FDK2"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="8">
        <location>
            <begin position="55"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="199" mass="23446" checksum="D04AF4F94C00E130" modified="2017-10-25" version="1">MYIKLSFHRIFTFKIPLRWEREGLCCIRYTFILLRFITEFSTPRNMIITGAYRRIGNICRSPIAEAVFAEIVKEKGLEDDWEVDSAALIGYHTGKNPDRRAMEVLKAKGIKDYSHKARTLESNDYTKFDWIFGMDEDNLEELERKKPQRCKATIELLGKHDPDGKLIIRDPYYDNNSAGFYEVYEQCDRSIRAFLQKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE33</accession>
    <name>A0A232FE33_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000346">
        <property type="protein sequence ID" value="OXU29036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE33"/>
    <dbReference type="STRING" id="543379.A0A232FE33"/>
    <dbReference type="OrthoDB" id="7701741at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF3">
        <property type="entry name" value="LD27203P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="254" mass="28200" checksum="5CCA1A6227B1A3B4" modified="2017-10-25" version="1">MRHLESCYQIHSVHGQVYQSCLSRSGLDNFSRRQICRLRSIMTAILALALFGAAFARPEEKKEEAAAEAKDSKSKRGLWDLGDFGGHGLEYGGGHGLELGGHFGGGSLGGGSLGGGHHDEGHISGITIHREVKVPVPAPYKVEKHIPVPYPVHVKVPVDRPVPYHVPAPYPVHVDKHIPVPVEKPVPYPVHVPVKVPVEEPYPVHVPVKVPYHVEKQVPYPVKVPVYHKESYPVYIKEHHHEHHHDLGHHGHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEN8</accession>
    <name>A0A232FEN8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_013875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000335">
        <property type="protein sequence ID" value="OXU29122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEN8"/>
    <dbReference type="STRING" id="543379.A0A232FEN8"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="101"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="440" mass="50627" checksum="F848BEBA2EF92945" modified="2017-10-25" version="1">MMGHNIHDEVPMTTPELITKHGYIGETHHVWTEDGYRLELHRVLRKAEGKNSTKISTESSREKLTELLKSVVDSQDDSQASILSEALNLQVTQDSNPQVKPPILINHGLLSSSADWVLLGPQKALAYVLCDCGFDVWLANVRGNTYSQCHKKYTTKDREFWDFSWHEIGVYDIPAMIDYVLEKTNQPSLHYIGYSQGTTTFYVMCSERPEYNDKVKAMVTMAPIAFLSNQRSPLIKFIVRFYILMEWGSAYCNIHQWFPRNKLQAKALGTLIRNTPGQLTKSFYSCWFYLVAGFGSNQLDKSMLPLIFGHFPGGSSAKQIIHYSQVILTDSFRKFDYGTSKNLKLYGSTQPPKYCLERVKVPVAVFYSENDFLTHPEDVKRLVENLPNVALKHKIEYSKFNHIDYLWGCDAKTLLYDHDHCQLNEYLAESIEDSERLAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF61</accession>
    <name>A0A232FF61_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein SERAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine active site-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_005662</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SERAC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000331">
        <property type="protein sequence ID" value="OXU29160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF61"/>
    <dbReference type="STRING" id="543379.A0A232FF61"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU29160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="706" mass="81510" checksum="05917ABCB6B3B65F" modified="2017-10-25" version="1">MIIQNYKRAVYYLKTSGICMVVVSGCWFLYQVRQTSVLLNSVVPTNILELEHKQAHYIYIDDPRLKDIFMFSHENDLHSSLKEKPKNLSYVVTKWWKSVNRNLAFRLFHLASTGDKTERKKAVHSLSSLKHLKDWHYRQIAQMLDAKTAVALARSPKADLRFFLNPPYFHERYKLYEIVDKLHNLLIKLNALCGGCHPCLLQFLHKKFQISHRDTTFFEHDLTSVGVSVPPPIVWDQNFLLNCVHAVHHHSSLEEHSKDVADAGGLQILMNVYKLVGDNVDICSLIAKILSNLSLHPEYLEDIFRSGWIGILASWSRHKDIRLAAPASRALANLDFDDNEDEKYPQRIYPLYPLHRVDFKKKLDVVFIHGLLGGVFVTWRQRDIDTSVPVPISKDEKVSLRAIVDDHPSEFLKDLARDLEVREWQRLGYDYEVILHDCPVNMNNKATGPFFCDGDDHCMQQSERDCISRTQCWPKDWLPKDVPNLRIIGINYNTNLSMWTPLCPIEGVRSTIKERSSEFTRKLIMASVGKRSIIWACHSMGGLLVKQLLVEEWKNGDKNNLVRNTKGIVFYSTPHRGSHVAALNQTTQMLVWPSVEVQELREQSPNLLQLHSDFLKMLQEHDIEIISFGETKPTRVTALKVPFRFVNPSSADPGIGEFFEIPQDHLSICKPASRQSFLYQKVLAMVRRHVEPINKSNLNSFFEKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFB1</accession>
    <name>A0A232FFB1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vps16 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000334">
        <property type="protein sequence ID" value="OXU29138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFB1"/>
    <dbReference type="STRING" id="543379.A0A232FFB1"/>
    <dbReference type="OrthoDB" id="9977282at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040057">
        <property type="entry name" value="Spe-39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364">
        <property type="entry name" value="DEFECTIVE SPERMATOGENESIS PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13364:SF6">
        <property type="entry name" value="SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47766" checksum="67A8A02CE2134999" modified="2017-10-25" version="1">MAVSNEDDDFWYSSEKRSFCFESSESDNLFGVSKSGTAQLRAGISNIQVTDSSPKYDEPQWSSKPLLSIISDNALAKILEAEKLQYIPDESSSIQPDVTLKKMLMGHAHSLEQYKSLASKTALLDAAIKSGNGNAILGVTIFIKRTLKRSLVQKLLIERPEALYTYINYLSKRMCTSEICDLLTAQGKTTEAAIKCTSIIVKNTDKGEGSIDILLTKITKHCNMMFSSLPDCRETTFVWSWVKLLEWQKNAHNKFSEPLKYNASALECLRLACKDCWGAPESSTHSPLWLVQNQEISPRQYQKIAITTRASVQSWDDIDNLLHKKGWLGGKKLQTNLPIEEVLKLLQDHQAPSGIIEKFLNYVDSGKRLEVAKNLNCHKAVINILAAQGDRTALLEYKASLRPQSEEYFYVESVLCSHSVRWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGE5</accession>
    <name>A0A232FGE5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000284">
        <property type="protein sequence ID" value="OXU29499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGE5"/>
    <dbReference type="STRING" id="543379.A0A232FGE5"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12912">
        <property type="entry name" value="PDC2_MCP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000057">
        <property type="entry name" value="Voltage-dependent calcium channel subunit alpha-2/delta-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VWFA" evidence="7">
        <location>
            <begin position="11"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="947" mass="106856" checksum="EF8F358B4FBE34ED" modified="2017-10-25" version="1" fragment="single">WFVGGATSPKDLAILVDGTSLSSSKIRKLVVATTNAVLDSLGPNDFVNVYRYAESAEEIVKCFKDSMLAASPENVKELKNAMNNLKSESPSNISAAMSTAFEILHKYNRSSQGSQCNQAIMLITSRSEGPPVDLIKRYNSPHMPVRIFTYLVGGDDSQELHDMSCNNKGFYARITNMEEIKSKVFEYIKVMARPMVLYQRDHPIHWSPVYIGGKSSRYGLEGQGQLMTSVTAPILDRRDHTERSANLLGIVGTDVPIDQIQKLVPPYKLGINGYSFLVDNNGRVLYHPDLRPLYEETLKRKYLSVDLSEVELSEFDGPMHSLNNSLLLDLRHDMIDQKEGETEFSVKIQYDDMKRVSIRRHNYFYKPIEETPFSLGLALPEGYGMFEVHAEQEIRHAKVNVTQYFKGDRWKVHPDWTYCEYYFESEKWFGTPEERVLHFLVQAHNPGWKWRSMRPKSPSSHQKPASKPDRDSYYCDKGLLQSLVFDAWATEDFDKRSEKSMQKEDNPIAILMAVLHSKGKGRFGVARSFIATRSGLLRWHDHQQNDDTREEPDFADNYRRAMDSTWYKRAVDQHSVEPESFVFSVSFDAADNPRPLVTATHAIFVESKGHKAPAAVVGIQFHHASLSSHFVNVTSTCFGNTVCKKNCASDELDCYILDNNGFVIISEKHEHTGKFFGDIDGTIMDSLVQDRIFKRVNVVDYQGVCSPQSSHISAAPTSSSYSILKTIATVGNFMWTWTVNLNLVDALQPIWAYASDSDNDGNLVYPDGENYPPEMTDEVTVENEDLPPYPPVAQPPPPTTTTHSTTTNFPPHKLRTCEKNTDLYILQPDRLNTSGQGNPLKGKLTNCHLSGCERPFSVQKISHTNLILLVVDTLCPCGTKKLGIRPFEAMSEPGACTARRERLYRRRPAKCINYHPEELEIKVCGGSSKTTSLQLGLLLVGLLVAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGQ0</accession>
    <name>A0A232FGQ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_006448</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000251">
        <property type="protein sequence ID" value="OXU29700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGQ0"/>
    <dbReference type="STRING" id="543379.A0A232FGQ0"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14338">
        <property type="entry name" value="UBA_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000154">
        <property type="entry name" value="Serine/threonine-protein kinase SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF74">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="34"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="370"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="452"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU29700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="587" mass="64975" checksum="D0ABDD13BC7BF719" modified="2017-10-25" version="1" fragment="single">EDWLDFLIVFGRIYEADMDAGAGQGKKQVRVGFYDIEGTIGKGNFAVVKLARHRITKTEVAIKIIDKSQLDPTNLEKVYREVEIMKQLEHPHIVKLYQVMETKNMLYMVCEYASRGEIFDYIARYGRMGEPRARATFAQILSAVEYCHATGVAHRDLKAENLLLDAQMCVKIADFGFSNRFAPGERLSTWCGSPPYAAPEVFRGKHYAGPEIDVWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPYFMSTDCESLIRKMLVLEPGKRYTIPQIKRHRWMAGATDSIRPVVPTTSPSLQEPNEQILRLMHSLGIDIARTRESLRNNSYDHHAAIYFLLLERLKQHRSRTKDEKFKSRGREEMCRSGKRFSSTSSSTDEGCCSAEGDLEEHQSQVQANGPATNGNGRAASIFGGVNNGGSNGSSSSEFFESSFDSGCPPDYTTTSSCFTSSLPSCTPPPPKSPSPVASRISRVAAQGRRASDGGPRLLFAQQGGGDRPVKQRSIQDSGKARGHLDLVHLRPPPASPQSQSQFKLRSVDSGTQLQLLVQQRMLQQKRSLFHRHRSGGSPTPLAGSANSSISSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHQ5</accession>
    <name>A0A232FHQ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_001106</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000212">
        <property type="protein sequence ID" value="OXU29989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHQ5"/>
    <dbReference type="STRING" id="543379.A0A232FHQ5"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="13">
        <location>
            <begin position="40"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="14">
        <location>
            <begin position="42"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU29989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="478" mass="52542" checksum="FB5D672CF94A1D24" modified="2017-10-25" version="1">MKVTNLDERIHVLDNNSTLMTVIKDIANSGLQEEAFYVLDVGDIVQKHQIWKEKLPRVDPFYAVKCNDSLTVLEVLASLGVGFDCASKNEINKVLDIGVDSSRIIFANPAKPASHIRHAAAVGVDLMTVDNESELHKIKKLFPTAKVVLRIRCDSEVAQCQLGMKFGCDPTFEAPSLLRLARLLDIDVVGISFHVGSGCQDPPVFNRAICHAKNLFDLAVDIGFKPYLLDLGGGYPGNKGSSIEKIADVINHALDEYFPTDDVHIIAEPGRFYVASAFTLATAIHSKRSVRADGNSPGNVTHTMYYINDGVYGSFNCLLYDHQHVTPIPLRPGHGKMIPSSIWGPTCDGLDQVVENVLMHEMELGDWIIFENMGAYTLPVASPFNGFPIPKVHVVADESIWLLLKDALPLTEEHFVLGDTPQNLRLGLDIGGHTDVNAWNNPAMELASSEISSEEEILVDSANPPSFIYDYVDVDPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI74</accession>
    <name>A0A232FI74_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000188">
        <property type="protein sequence ID" value="OXU30158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI74"/>
    <dbReference type="STRING" id="543379.A0A232FI74"/>
    <dbReference type="OrthoDB" id="6752769at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="469" mass="53088" checksum="494F9846C0E92EB5" modified="2017-10-25" version="1">MAARSQSSRASSATPVPVVTDSGVEQGVRKRYPQIEIAKFSREIRNWVRFRSQFKKLHEDTKLNNEDKFQYLLQAMVPNSRAAETNRISGGRKQSEPGAAKKTKEKAAGKEVASGAKFADFKKQRDQAKRTDEPSAKPKNSVNAINIQKKCSLPSSNETPSTFMQTLKLRMRNDTTEIIVRAVIDTGSQHSYVLRDVANQLNSTPIAQQDMIHLLFGGDKSEIETNNKYQVRVGNMDGSFWCNFEALDQKIICVDVPSVTKGSWLQELEPLSIKLTDVCSKEKMVALLIGADIAGQLFTGKMHVLKSGLTAIETRLGWTLMGKVPKKRPTINTHTNLAPASISMYVKDADIKDLWSLDVLGINDPIDHKTEAQHNFEVVRALTENIVINAEGRYEIKLPWRECHPELKDNKKMAIQRLEPVVKKLRAADKYAEYDWIFKEWLKEGITERVPPEEEAYWATYLPLRPVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIU9</accession>
    <name>A0A232FIU9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000143">
        <property type="protein sequence ID" value="OXU30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIU9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7205" checksum="4EA7C0F6CEBA05A7" modified="2017-10-25" version="1">MSSTPDFWLATTIFPDTRQIQPQRASLIYTFDTIAPILTIRISCVFVAPKFLNSLIVRKIYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ36</accession>
    <name>A0A232FJ36_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000123">
        <property type="protein sequence ID" value="OXU30756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ36"/>
    <dbReference type="STRING" id="543379.A0A232FJ36"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="72"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="16947" checksum="B85A15FA08C54DB1" modified="2017-10-25" version="1">MNVITIEFECTYTCAPIHCDSNGNITVNCKFTFHGSVPRNYFGDSSLESATISSKTSILDEYEKLLGSAKFSDVTIVVGEKKFPAHMNILAARSPVFSAMFEHDMLESKKKIVKISDVKPEIMTEVLRFIYSSKVKNLTESTTELLAAADKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJB8</accession>
    <name>A0A232FJB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Tenascin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_009859</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Synapse</location>
            <location evidence="17">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000121">
        <property type="protein sequence ID" value="OXU30772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FJB8"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099559">
        <property type="term" value="P:maintenance of alignment of postsynaptic density and presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001941">
        <property type="term" value="P:postsynaptic membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097090">
        <property type="term" value="P:presynaptic membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034110">
        <property type="term" value="P:regulation of homotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000331">
        <property type="term" value="P:regulation of terminal button organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051124">
        <property type="term" value="P:synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016200">
        <property type="term" value="P:synaptic target attraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048499">
        <property type="term" value="P:synaptic vesicle membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.180.10.10:FF:000008">
        <property type="entry name" value="Odz, odd Oz/ten-m homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000021">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000474">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000033">
        <property type="entry name" value="teneurin-a isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000189">
        <property type="entry name" value="Teneurin-m-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057629">
        <property type="entry name" value="Teneurin1-4_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF72">
        <property type="entry name" value="TENEURIN-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23093">
        <property type="entry name" value="GBD_Tenm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="969"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1007"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1171"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="501"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="758"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="3130"/>
            <end position="3163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="3143"/>
            <end position="3163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1175"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="1197"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00084038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU30772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="3163" mass="353260" checksum="47D608FEFA2F297E" modified="2017-10-25" version="1">MSRLNGRLPGSHAASDHERDPDLEPSCLVRTPSGNFYNISKKPKNDYNNKNQSTGNSPIKVELQNNMDRMPLPYGHASSMIPMRRQSIRCHFRKGIDWCSWKLIAIIVIMVSLCLLAALTYVAASNMVNWYQGTKACTVLVGDGTDGSKSALDGTAAGKNSSSSSTPSSSSASGSGTGGKRQQSGSGGNSQLPVYARKRRAADYDEHDSPAVVVNDFADPRMHDGSATTTAATQVVNEEAKLETQTTISSDTNTRSIAPINTSGSDESFVSFSPDESELVTGDGRSISDREVLDTTTLSYEELESSTDGYGDDSGTTIVDPGDFIEEIEDVPEALEDDASTSTERNEAESETVVAHATDEPFIESTTPKIPIDVLSEDEKQTKETSHEEVLADQADEELQHDSPGPFNFYQHEDLEIVNLKSEVTTDKLAKTKDPSYTENDVTLIDDSSTYDEDVRELEELMKKPDKREFFRKLDEKFGVVSDDKTRTKIVSRPKEENDYRYLSNSLNRSTIENTNRNATSQSNSSTSKTNIHQDDSSVTPSAYTVEQTTKQHADQLKASTNVVLVNVTIASGNAKKPLYVVSVSVPTNSETSSININVPPYPRESSSSNKSEHEKATNHVTESIEKSLASIQKSLGTIEKTLGLGEKLPRDIDMMSAKVTEASEFVNASLANKTTATNNSEEHGSKEILVTDMGIALTLPPPPKPPSSPPPPVWAGGECECFCPCMDMLESVSEEPDPYWDEVVSDEPLLFEDYSNTTETEVEGNATTAQMSLSKDEMTTSRSDEDGRTKCEVATTAMPPEPVILILEGGRTFPARSFPPDGTTFAQVVLGQRLNKEIPAYSYWNMQFYQSEPAYVRFDYNIPRGASIGVYARRNALPTHTQYDLLEVLSGFKARTTRSSHQPSIKKEVTHYMEPGHWFLSLYNDDGDPQEVSLIAVIAEDMTHNCPNGCSGKGECLLGHCQCNPGFGGEDCSESVCPVLCSQRGEYINGECQCNPGWKGKECSLRHDECEVPDCNGHGHCTNGKCNCVRGYKGKFCEEVDCPHPTCSGHGFCAEGTCICKKGWKGADCSQMDKEALQCLPGCSGHGNFDLETQTCLCEPMWSGDDCSKELCDLDCGPHGHCVDNACDCLPGWSGELCNLKQCDPRCNEHGQCKNGTCLCVTGWNGRHCTMEGCPNSCSGHGQCKVNSDAQWECRCYDGWNGKDCSVYLEQDCSDGRDNDKDGLVDCADPECCSNAKCRSSQLCVSAPKPIDILLRKQPPAITASFFERMKFLIDDGSLQNYARQETFNESRSAVVRGRVVTSLGMGLMGVRVSTSTPQEGFTLTRDDGWFDLLVNGGGAVTLQFGRSPFKPQSHIVFVPWNEVVIINKIVMSTADEKPPVHVIHSCAAHDYDLMKPVVLATWKHGFQGACPDKSAILAESQVVQESLQIPGTGLNLVYHSSRAAGYLSTIQLQLTPEVIPPTLNLIHLRITIEGILFEKTFEADPVIKFTYAWNRLNVYRQRVYGVTTAMVKVGYEYSDCKDVIWDVQTTKLSGHDMSISEVGGWNLDIHHRYNFHEGILQKGDGSNIYLKHKPRVILTTMGDGHQRPLECYDCDGQASKQRLLAPVALATAPDGSIFVGDFNLVRKILVDGTVKTIVRLNATRVSYRYHIALSPLDGSLYISDPESHQIIRVRNTTDYSDPEHNWETVVGSGERCLPGDEAHCGDGALARDAKLAYPKGVAISADNVLYFADGTNIRMVDRDGIITTIIGNHMHKSHWKPIPCEGTLNVEEVHLRWPTELSINPLDNSLHMIDDHMVLQLAPDGRVKVVAGRPLHCASPSSTFDTELATHATLVMPQSIAFGPSGDLYIAESDSQRINRVRVIGTDGKISAYAGAESKCNCLERGCDCFEADHYLASTSKFNTISAVAVSPDGVVHIGDQANYRIRSVMASIPDASDAREYEIYSPDTQEIYVFNRFGQHIATKNILTGETIYTFAYNVNTSNGRLSTVTDAAGNKVFLLRDYSAQVNSIENTKGQKCRLRMSRMKLLHELSTPDNYNVTFEYYEPTGLLKTKLDSTGRSYVYNYDEFGRLTSAVTPTGKVISLTFDLSLKGATVKVGQNSRKPVSMLIKGSSVVTKIGEAEQRTTVLGDGSVGRMTPWSHTVSTDTMPYSILAEIEPLLGESYPVPAKQRTEIAGDLANRFEWRYFLRKVQANKNRGSSNAAKAIAQVGRKLRVNGDFLLSLEYDRESNTVAVFKDDRVELLNVTYDKTARPIKWGPRDGIFAGVDLEYDRFSRLVSWRWGNMSETYGFDQAGRLYEIKYSDGTSMVYAFKDIFSSLPLKVTTPRGSDYLLQYDEAGALQSLTTPRGHIHAFSLQTSLGFYKYQYYSPMNRHPYEILYNDDGQILAKVYPHQSGKVAYVYDHNGKLETTLAGQSSTHYTYQETNSLVRSIDINEPNFEMRVEYKYHAGIVKDEKIKYGSKSGLDNAHFRYQYDGNARISGIDVDVSGKQLQPIRLKYDQNLGVLEAVNDLRIYRNLFNRSVMQDSSKQFFTVTDYDEHGRVKTILMNIRSLDVFRMELEYDNRNRIKMRKLMIGKDSVEKKEWTRMDKITYNADGHVLEVADTDISWQYAYDENGNVVGVTERNEKITLGYDSGDRVVQYGDVEFNSYDQRGFVVIRGEHKYRYNSRGQLIHAAEHKQFQISYYYDDRGRLVAWNDDRDNVTQFFYANPKTPDLITHLHFPKTQRTFRFLYDSRNFLMAVETSEQRFYVATDQNGSPLALFDTNGNLYKEMRRTPFGKIIKDTNPDFYLPIDFHGGLFDPNTKLIYLNKRLYDPTVGQWMTPAWEQMANELTTPTDIFIYRFRNNDPINLKQNVEYMTDLPSWLKLYGYDINAMLGSEYTKEMVYQPTATITSPQLTPDFGVMSGLQCIVNRVHDKFSDLGFVPKPLLKLEPKTRNLLPRVAHRRAVFGEGILVSRIGGRALVSVVDGVNSVVQDVMTSVINNSYFLPLHFSVHDQDVFYFVKDNALKIRDDTDELKRLGSMFNVSTHETTEHGGGTYKELRLHSVDAVVVIRYGADPEQERHRILKHAHKRAVERAWEIEKQLVAAGFQGRGDWTKEEKDELISRGIVEGYEGVDIHSVHRYPQLADDPGNVMFNRDTKRKRRKSGSNRRARGYRHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJY9</accession>
    <name>A0A232FJY9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_009747</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000100">
        <property type="protein sequence ID" value="OXU30982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJY9"/>
    <dbReference type="STRING" id="543379.A0A232FJY9"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="858"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU30982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1051" mass="120324" checksum="DEEDAD50826246F9" modified="2017-10-25" version="1" fragment="single">MPQVHDAGTAPEPLPNNLNVSVAANHLDLAGIAPVFNNNNLNRARNNNNQNPLFSVRDRLFHALFIKSALLYARTFPRPVRRMIEFVVLLKAIMAFFVLVYIHIVFSRTPANCLEHVRDDWPRDGILRVEILRNAGEDYSIEKSYAKEEKLRQEKVEDLSSVLGILARDGFINIEPSAVDDDQAAHASDEGLQNLTLSEKEMNLRGAALENLRNFSAANAAINPFLSTQHWDGYPKDQPDEATQATTKMQDNITSKESTNTPIRDNIIQPLKDQVSEVEKIVKAVFPEDEYIVEYSLEYGFLRLSPAARQKLNIPVKIVTLDPLNDKCFGDAFSRLILDEFLGYDDLLMASIKTLAEHEDNKGFLRNVVTGEHYRFVSMWMSRSAYIAAFFIMLVFTVSISMLLRYSHHQIFVFIVLIAAYGLAVGLLYLLYMVVNQFTYWNQRKILHLKVTPLFGNFAPIFFRRNSFPEHAKFLYNYLPDAKYYGTFDFNTPVIVLKDPDLIRDICVKNFDNFPDHRSFVTEEMDPIVGRNVFSLKGQRWKDVRGTLSPSFTANKMKIMFQLITECSREFVQYFVDHPELAANFEAKDAFTRYTNDVIATAAFGIQVNSMRDRENEFYVHGKDATSFSSPLRLIKFILFRSFPKLVRMTGERFLSRSTDKFFNQLVTNTVRTREEQKIVRPDMIQLLMQARDKEDGIDVTIEDIIGQAFIFFLAGFDTSSTLMCFAAYELAAHPDIQEKVFREIEEQENGEELTYESLAKMKYLDMVISETLRMYPPSPMTDRVCAKEFVMPPAKAGEPELRVEIGTNMVMPIYGMHHDPQHFPEPEKFMPERFSDENKDKINPYIYMPFGHGPRKCIGNRFALMETKTLLVHILKKFRIKFTDRSKYPIEFCKKTFNMTQKDGFWLNGSSTNAGVQQHRVLPGCLSSNCDFGACRKALPMAAIITTSQCPNVLFSNPIKDQAAGATEYREPAAHHAFNTFAFIMSRSNPNTSNLVRWRSDAATHWPAATEQQRQLGQREILPSISSPSRFAVCAELPPWAHSDVRCADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK88</accession>
    <name>A0A232FK88_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000124">
        <property type="protein sequence ID" value="OXU30737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK88"/>
    <dbReference type="OrthoDB" id="6606882at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="188" mass="20612" checksum="0E6513BD5C1D75BE" modified="2017-10-25" version="1">MATVFESPFLSNRLRQIEERYEEPTTFGRCDCTSYSYLVLSIVLFTIGTAITILALGDVVDGHVFSHLGHMWLVGPIFICSGLMVAVKCMLYLRRKSVIQMIFHQRQLFRHLQEFSGGQAMSSSGSGTPGPPPYEVIAQSQGPSELPPPTYAEAVALLQQTGIQDAKPCGTVDTGENNCVMPRPTSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL35</accession>
    <name>A0A232FL35_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000093">
        <property type="protein sequence ID" value="OXU31057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL35"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7023" checksum="B17D019726270CB3" modified="2017-10-25" version="1">MREDLKQKLLPLAGAPQCTAGTMDLINLAAKTPSFLPTRRIRDLEHNKISKKVVKIVKFYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL66</accession>
    <name>A0A232FL66_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_015945</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000077">
        <property type="protein sequence ID" value="OXU31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL66"/>
    <dbReference type="STRING" id="543379.A0A232FL66"/>
    <dbReference type="OrthoDB" id="5779068at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14513">
        <property type="entry name" value="DSP_slingshot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="112"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="171"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="698"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="911"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1127"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128355" checksum="8EDB9BDA79AF64B4" modified="2017-10-25" version="1">MLSLGTFYALALLLLPVLVWLAKVIKRKPYVDVFSGIARVARSALQTLHKVSSKAREQNYFLGGLSHDWVSYYEQRIESDRSCLNEWHAMDNLESRRPPSPDSVRNKPREREETEKVIRSTLKEIMMSVDLDEVTSKYIRGRLEEYLDMDLVEFKPFIDQEMLTILGQMDAPTEIFDHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGMFNYLNVRVYDDEKTDLLKHWDNTFKYITKAKKEGSKVLVHCKMGVSRSASVVIAYAMKAYNWDFSQALKHVKDKRNCIKPNNSFLSQLETYQGILDAMKNKDKLLRSKSDTNLESPTLLIKERGKKEEKPDVNDDNDSESLVDEQSGQELKKSGQRPKSWSPNLELAEDVLPTAPLSQSLESIDKSANPEVTREDLLRGSNPKTGTENVNNNSSSCHAEEQQQQERNVLMHCGQSYSVSQNQIVHLPGPESTNSQTQSTSCVSTSCKHARQNQGQKRKGLVLNLTNQFEAASSKPSSPSSDGEGGRPAQPQCVLENGCCAHEDYADTEQQANAGDNSECLVWTASTEVKCIHANGSNSCGSNSNSRDSLDLSAESESTTSSTTTTLAATSQSGRKPKRDGDPFSAQLDRVFDREERQPRESPSRQSSWSSYDSAVVMDNNSVHSSWATLPSRNSSWGSYDMRPSGESLGSSGLFPYDREEIPWHPGTVKRTKQKLEESSTTGTSKRVCTQLSDPSSDEKAAERLAAASEVEVDNPSEVLLHYTSSPTPRRRDSSPVRSEHRSTVDTQTSLAAAEPIDISLVSPRQSPTSSRLSRSAPVPSSLAADAELAPLALRSCKSESETSSPCVVNTPQCPSVKHHKMVLENLCNKPMFKKRGLPSAPGTVATSIAVDDCSPESECPPRSTSGIVKNLKKEFEAKSSSKLEKSPDSSSFEAGQENYPGGSLSASNPRQKRDGKIRSLPSSPVIPHNDSKIQASSSMSEPTTRESRTSSFAKRSSEPPLSTTCTEQNTDDSSLEDLSVKVLVGKYEVAKPESKRTSEVQLRVSSSSQHHHNHHHHHHHHHHHHHRDRDHVVEHPPAKSKIAPDLARRSAPIIINHHAASLFDSQATTEAPGRPPSVPSPSQVVTSVIAKAASKKQQQHGRTHPLARLQVRPRHSSPVYNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM32</accession>
    <name>A0A232FM32_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000035">
        <property type="protein sequence ID" value="OXU31722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM32"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="491" mass="57589" checksum="521E17C943529EE8" modified="2017-10-25" version="1">MFLLHGLQLPRFCSLEVLLLFIRKNFDINSSKLYKRKEYSSILLKEHRIDIMNKLRLFDLIENLNIEELNYQLQFLTNIMKNSCGSEASTNGLSLTKSYVRKQSEANKKHMHLSLPDICSGYRIIKFSAVLVHTYTYIHTYTGQSIGDALRTLAYLHMHSQFHRLYKRKEYSSILLKEHRIDIMNNLRLFDLIKNFNIEEPNYQLQFLTNIMKNAWGSEAPANGLSLTKSYVRKQSEANKKHMHLSLPDICNGYRIIKSEANKKHMHLSLPDICSGYRIIKFSAVLVHTYTYIHTYTGQSIGDALRTLAYLHMHSQFHRLYKIKEYSSILLKEHRIDIMNKLRLFDLITNLNIEEPNYQLQFLTNIMKNAWGSEAPANGLSLTKSYVRKQSEANKKHMHLSLPDICSRYRIIKNTLVLFGNLNIKKFRDIPSIDIFQIDKITSTSDGFQDDDIDLHILENFMKIDYFEKLKCFILSKGLMQIYVCKKSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FP60</accession>
    <name>A0A232FP60_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FP60"/>
    <dbReference type="STRING" id="543379.A0A232FP60"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU32147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12848" checksum="A9134281752FCF8F" modified="2017-10-25" version="1">MESHESTFCSHTYLVYSPTSSIGMFDQQQQQQRQLQIVSVESLNLQCERCGKSYSLKHNLQRHVKFECGGQRKFCCHLCPNKYTQNASLHRHLLHHHYVDPRKAKKKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED77</accession>
    <name>A0A232ED77_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007547">
        <property type="protein sequence ID" value="OXU16305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED77"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="115" mass="13526" checksum="97B87F831A711A83" modified="2017-10-25" version="1">MNARRKDGHLADVRGSWWRKNELYSTCMIVKLRTQREGDQSPMAPKTKSGPTFQAKIAMNARRKDGHLADVRGSWWRKNELYSTCMIVKLRTQVQTYHGEFFFTKNKSLIKKMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDS8</accession>
    <name>A0A232EDS8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005976">
        <property type="protein sequence ID" value="OXU16501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDS8"/>
    <dbReference type="STRING" id="543379.A0A232EDS8"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU16501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12033" checksum="E90C5DFFBDF30943" modified="2017-10-25" version="1">MANGMDTVVQQNGGSNLGQSSQEESKTNLIVNYLPQTMTQEEIRSLFSSIGEVESCKLIRDKLTAASHHEDLDDKSHLMYMNDFQQRKGCLVFDRVISSSRGSEQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EED6</accession>
    <name>A0A232EED6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005371">
        <property type="protein sequence ID" value="OXU16719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EED6"/>
    <dbReference type="STRING" id="543379.A0A232EED6"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU16719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="14754" checksum="20BAF848D715443C" modified="2017-10-25" version="1">MTKSEQAESGGQVQVDFAEVVKENTKFTWYMTVIVAGIGVIAVMFYAIFRELFSKKSPNSVYSLALDRLMNDPKVIDALGSPIKAYGEETRRGRLGHVSHTSYEKNGVQYMRMKGPRNFLMETGFRQNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF76</accession>
    <name>A0A232EF76_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005111">
        <property type="protein sequence ID" value="OXU16984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF76"/>
    <dbReference type="OrthoDB" id="7687833at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10255" checksum="12A99633BB09E680" modified="2017-10-25" version="1" fragment="single">FTLRRDFLRGLKKMSEGGVSFEDILRHVMRHLRMTETKAAFRVKQVLRAGLALQRIEKTAQGRYRLLAPAKPPGLAVRIKSGSDDSCSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFM5</accession>
    <name>A0A232EFM5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004976">
        <property type="protein sequence ID" value="OXU17151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFM5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="350" mass="39248" checksum="031C74D3DA6301E3" modified="2017-10-25" version="1">MSYNKAVSHFGINGVNAKVVYNTNLNTCSELAKYFSSFKCTLNDGVNFINSNENIVIQNDECALTSSQEDLMSLIDDFTAQYESLAYNRYTNAGTALHPTSKTDPFAHPVNNGEHLRHHSYAFDSFSKDDFTSNQGNFRAQNYGKSLYYNEYINEVGVATSSHIDLTNCNVSNKANHLVRTQNNICAGGYRHLYSNIKANPCNATGLTSKAIVDNGKRILRVLDTSSTCSANFVNNYESRDKVKLKDSRAVQSNYAMDSFVFNKENLVGQTQYNVGGQHVLSPTSYATVASSARKRKRQGDDDHLTELTDIYCTMCSEIPWNLNHKSKLRSSSKKCLYCCPKTQKYARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFQ5</accession>
    <name>A0A232EFQ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004953">
        <property type="protein sequence ID" value="OXU17190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFQ5"/>
    <dbReference type="STRING" id="543379.A0A232EFQ5"/>
    <dbReference type="OrthoDB" id="8192535at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="15196" checksum="F8C7AA51D2DA4292" modified="2017-10-25" version="1">MLVIQILKIHNLIAATKSFSFDRREARPISKKRITFHTKDSNVSQSQQKVNSKSEPKEDKKSQSKASAQSSLAPLDDDADNQGFAEWLRSGDGVDMMRLFVIANSLVVLLTMTWPHIQLTFGIIRELIFGEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGG6</accession>
    <name>A0A232EGG6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004767">
        <property type="protein sequence ID" value="OXU17443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGG6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="112" mass="12803" checksum="22C707C27C345135" modified="2017-10-25" version="1">MENERLRNELQIARRQANIFMLSHESDLHLPLKGKPNNLSYVVTKWWKSICAPLSSLSTLSFGFHRRQNREEESYTFSPFTKTFKRGAESYANADVVANNGTSFLNGPDCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGG8</accession>
    <name>A0A232EGG8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004773">
        <property type="protein sequence ID" value="OXU17434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGG8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="13412" checksum="F0864DEB0515F9E2" modified="2017-10-25" version="1">MLKPEGDDEQLLVPTSCKTCTDAIKEGGKTIQVCKNCLVAANKTSCSTSTSSISSRSSSPLSQQQTRYRKPASAPPFASPSRSSSPSRKEDSVLNKILDKLNKLDNIEKQPGAIAWRCVVPGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGM7</accession>
    <name>A0A232EGM7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004721">
        <property type="protein sequence ID" value="OXU17519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGM7"/>
    <dbReference type="STRING" id="543379.A0A232EGM7"/>
    <dbReference type="OrthoDB" id="7548151at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU17519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="353" mass="40531" checksum="D0EDEC55B38E6AFE" modified="2017-10-25" version="1">MMELELLRYKAYTENVIWFLKLVGLWPESQPLPKKILSTITLSSILVVVVTVSNFSFHNLSNIVVFTSGMCMAASSTSAFSKIAMFLLHREDVVYLNKYLSGGFMRDMREPNNRPDLLNNVKTFDRLMVTHVICVAIAMFTYSIRPLLVLRKHGKYIRSFPAIYPFAYEPGGLVHWILYAVEVSGTASLWTVTIGVDCIFGVYALQVCGELRVLSRKFRELRASDNYKENLRDCIQRHHVLINAKNKLDNIYGLISILLITSATLVLCSLVFQVSEVCMRTPVKSLLSSYFPYNRLCHINMYYIRFATTVLFKLIKTNSYLRVAHLCVYLIPKFLQIFTYAWYGNLIAEEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGN5</accession>
    <name>A0A232EGN5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004750">
        <property type="protein sequence ID" value="OXU17472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGN5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8801" checksum="F2FD69A9024E87B9" modified="2017-10-25" version="1">MVETKVVGYRGESLMVTLDLTLSLIFKVISRVIFLFWVAKVISKSCRHFNKIHLRNSSGNARIEKIVDISCTISREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH58</accession>
    <name>A0A232EH58_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004589">
        <property type="protein sequence ID" value="OXU17685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH58"/>
    <dbReference type="OrthoDB" id="10625343at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556708" evidence="2">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="20757" checksum="2D80BC7BDCA9B0AA" modified="2017-10-25" version="1">MFTKALIFVLLGTTLVLANPISQENSVEEQTEKNWKAKVQDWLHHVEETLKEYYEQGKKSFEEALNELKQKGEKAVEISKEKWAELKEKYQEIKEKAKVAIEEKKMIWEARLEEWKNKGQEALEEGKEKFQELKEKAKEAIKEEKAKWQAKLKEWKLKAKEAIEAAKEKLHEKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH63</accession>
    <name>A0A232EH63_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004597">
        <property type="protein sequence ID" value="OXU17671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH63"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="160" mass="18534" checksum="6AFB0CDF0EE897C6" modified="2017-10-25" version="1">MHKTKPNYAILRGRKLIHLSNTTISSTNAFMGRREQVQVLDSVMPKRVNLIVQQQLHSRCLKMGSITLLGLTHTLPQNRKCDEETENFVKKSLKLGCVKQNIINAVAEKGKNRRILKDIHNIEQMLKKSLKSNDLAEVLAFLQKNGITKLEYFFYFIIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHE8</accession>
    <name>A0A232EHE8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004514">
        <property type="protein sequence ID" value="OXU17790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHE8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23383" checksum="8C5127E4551C875E" modified="2017-10-25" version="1">MPFLLFTISSIFYLSIIWNHACRNILLSAIRKLDTLLLQNQNINARRNEVAVPVIYDKLDILPIDNLESLKQFDQNLVKRDPENVDLQTQFRNKISSCGETEMKKAIIMTLPKILTNELGTKLVWMIKAEGKVPIQNFNFPEIIAIITIVEKFHSFPATFSDKYHCTKEDVKARIKLWLQKSGDRIRADLKKAEKNRDVAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHF6</accession>
    <name>A0A232EHF6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004530">
        <property type="protein sequence ID" value="OXU17758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHF6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="243" mass="27480" checksum="45EABA2733AC7406" modified="2017-10-25" version="1">MKNLNTNIEIVILSNAFAWDSLVLLLAARSQGKCIRSQYVHLFTCSMLHRNNISAPRVKRSYKERITAAKKQSYRDYVTREGAENIWGYPGKRITGKIRIPKAVNTIVSKSGSVTNDWKETSPNPWTMGLPGIPPLCLWKAPRAVYNKNLGFDYTYKMNQTNDSMSPFWQPVVLLERMSIDPRRKLLNTLGHDRPQARKRLWSQTDPTPPESAPSGKRRALGKDRQPTRGQAISAPNDGTGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHN4</accession>
    <name>A0A232EHN4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004485">
        <property type="protein sequence ID" value="OXU17832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHN4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="24135" checksum="80D2CD3F5602DBA7" modified="2017-10-25" version="1">MSRSNFSTGHHPDDPPPSYEDIVCPSNTTEDASNSLEELAKATHMRFINGGRVPTDKTAQGLTPTTPPCEAIGGGVSQYVRAENSNFLAGTILEVPISDSEYAMEREYGRVPSPSPSTHRSPRISPNVNNTFYCDDLEEVDRSKLSNAEYRALLARRQRTIEAEVRRLDQAEQNAQPAQISNQTNDYNPPYLKPLIIVAFIISGMIFMVCLLIRFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHN8</accession>
    <name>A0A232EHN8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004468">
        <property type="protein sequence ID" value="OXU17854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHN8"/>
    <dbReference type="OrthoDB" id="7555456at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24493" checksum="136E94C315562230" modified="2017-10-25" version="1">MHTRKDPGQRLMRWMFRFTGYKYTFKYKPGKLNKNADALSRNPPEMTEKEINENLPKIKVIIIDEKTKQNGNKTKSNASTDGTTCRNRGHSASERITAPRGRGKSVGAKTNKNAPKLDHSVIEQRMRGRKAISKEESSKDTQRIETERPPLPDPRYIGLRIDDYQSEDSDSDGDASLTDSQNRTIMLVSSEEPSNTEANTDDDSVRESSIGTTLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIP3</accession>
    <name>A0A232EIP3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004184">
        <property type="protein sequence ID" value="OXU18226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIP3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="275" mass="30558" checksum="282D91B1D60E2F46" modified="2017-10-25" version="1" fragment="single">FCYSGVFAVAEHEYRDGNALLGSWCPGWSVSTSSTTVSRKMNNFFVVTPTATLPEVPGAQGGQYHVVSWILRSPNTNIVTLTLLEVPSAQGKIRYSRISGATEHGYGAILKIIPKDDVDTVYPGHQIPRKRLLSLYSYIVTSKTPNQRVSTKYVETTLIQPTLGAGYLKERCRRYIRVQGPQKSPINESGQKMSLIFHETPGDDVDTDNPGHREMTLILSTLWAPGTSESIAVAIFVFSDPKNPLVTKLYLLSSIFTTLFWFDALLFTFEVTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIW6</accession>
    <name>A0A232EIW6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004153">
        <property type="protein sequence ID" value="OXU18284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIW6"/>
    <dbReference type="OrthoDB" id="7399621at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="21241" checksum="AFB93D7075CA8396" modified="2017-10-25" version="1">MAIPFALPSDEDAEDQSQQQLEQLMLDLYAALQQVLRARNSQHPSRNPMMMPVPSPRPKPRRRRLTSEGSLPEKAQLPQRLDSCTGGRGTCCAHHLAASLDEREWATVGANLRNIADDFHASKTKDAEVEKSRLPFIGSSFSSSTSGLGSSGLGSSPSGSTDSILSLLMPAPLRETLWTTLALYLGWRLVSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIZ4</accession>
    <name>A0A232EIZ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004131">
        <property type="protein sequence ID" value="OXU18326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIZ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="26" mass="2954" checksum="7AA45542889707E1" modified="2017-10-25" version="1">MCLRQCVPPLNSLAWQSQISPLAFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJH2</accession>
    <name>A0A232EJH2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_003726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004039">
        <property type="protein sequence ID" value="OXU18458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJH2"/>
    <dbReference type="STRING" id="543379.A0A232EJH2"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="301"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="796"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU18458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="112954" checksum="15E8393D1417EB6F" modified="2017-10-25" version="1">MFILKMVIVQCTNDDLDSKSKNVCGKTESGTAVLEERVNTDNPRLFGLISEGESVINANMLAHGFGHETVQLYYNYTMKVAQLLGADKQRAALELREVIYFERRLALVADPICVSRHTAATNIQSLLANLHEIVHALDTDMYIFDETGSIKQWYTDKSANEYINRTECYVQQYERYVDQQTGLTLDGLRRLTIKLDNHSPDDIRVLGMMSNSHEFAKSFNCPLDSLKLELNDTNVNILVHSSLKPLIISSYRLLGIILCLSILAINFTESNEIDSAKICTTPGCFSAANLIKGNIDQTNLPCHDFYKFACGGFINKSVIPMNRQSVGHLDSVREKVLTEVRQLVNKKFKPKEPRIFKLVKNYFRACKRETTEAKNNSLKALVGYIDQLGGWPVIAGDSWDAGKFDVFKTDYKLREIGYRPKSILNLYVFNDLFNTSRNFLYVGPPQAEIKSEIFKRGFMNEVVQAYYNYMVDIAVILGADRVRATRDLRKALDLERDITFVSIIIRISVETELASSFPSIASAINLRRLEDLEKDAAFVPWIEYINAITSPVVSFELFEAVNVPDLGYLKSLDYFLRKTPKKVMANYMIWKMIAESAIYLTDEIRERTFEYQRIKSQTAVPKPRKPRWQECIELLTDRDRGLMVGVSSMYVRKHFSEDTKEDVKEIVTYVVDGFKDILENVTWMDAATKIAASRKNEFMKQIIAYPNELLNNKTLASYAKNLDVRPNNHFQNYLNLQRFHFNFELTGIGNLSNNSLWTIFADSTVVNAYYYAADNAIGKSAILKINFPNSLRPAAVLLAALLQPPLFDVSWPSFAKYGSIGFMIAHEIMHAYDARRYLYDETGSLNPWMEKHSREEFKNRIQCFEDQYSNFTDKDSGIHVDGSLTVNENLADNGGALIAYHAYEKWTESHGQEAGLPGLDYNATQLFWISAMSFLCSRDTPQHLQDSLKSSEHTPDKFRAMGISLNSLHFSKAFNCPAGSPMNPLNKCKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJZ6</accession>
    <name>A0A232EJZ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003904">
        <property type="protein sequence ID" value="OXU18680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJZ6"/>
    <dbReference type="OrthoDB" id="10522392at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012963528" description="SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18770" checksum="261F0B671008DDFB" modified="2017-10-25" version="1">MLAKIAVLLFASFAVTMAHPAFSPNDLASQLQNTLQNGPMQPFSYLQQAVGDVAERASNAYVTTYDQQKNSIDQTFENVKTTGQKGIESTLGLLKNGLEFIFILPRFGRNALANAQQQSPQQQIQQLQQLQLLQQQLFQQQLQQQQQQQQQQQQQLPQQKFQTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK58</accession>
    <name>A0A232EK58_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003900">
        <property type="protein sequence ID" value="OXU18691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK58"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11642" checksum="4B6CDDD42CB5EAAE" modified="2017-10-25" version="1">MYCDGVADRFVGVMGGFKSNIIQIWLIKTHAKLMQLEIRIQRIDNLVTSALYTSRAMKNRAQNRILRVNSTQSPLVILIFLVFSCFFFLDLEASLVPFGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK69</accession>
    <name>A0A232EK69_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003857">
        <property type="protein sequence ID" value="OXU18756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK69"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="163" mass="18353" checksum="F707A5165B894B30" modified="2017-10-25" version="1" fragment="single">KEKPIKTTSHIIRGTSISHCHHAVHKLNNKARKHFNSSCHKNRHYSNAPATQTGNTVIIIFAPSNSTETYDQGQGKRLKSTPRSPQGRGDVQANESSPIHKERKRSRGEMLIEHSDSYTRISPPSKPPLLPTPLNQDKPSTFLKKKKPLVTETLHQQIQDNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKC1</accession>
    <name>A0A232EKC1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003813">
        <property type="protein sequence ID" value="OXU18814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EKC1"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000663">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="511"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1609" mass="180111" checksum="F6621245D4C65CF2" modified="2017-10-25" version="1">MALLWHDGGNKRMVPEQLAALKTLAPHVDGATLSQLLSCCHALITEEAVSLGLPDFPLDNLSSAAIILENFPDFPLFHVFYRFYPYKLFLNQEGRNAVEDILKTFSVFDSKIAKDDSPKNFSFQNVNKTDGFSEITISYDGKESSTVKIPHGSGLLPTASESPYIETNYQNSLVAQMIQSQSNLDLCLIGPKGCGKSITVQRLAELLEYQVEPIILYQDMTSRDLIQYRTTLLNGDTIWKDSPLVTAALEGKLALLDGIHRIHPSTLAVIYRLVHDRELQLHDGKRLLRADRYDEIKSECNKTDEDMEKSGVYKIHPSFRIVALAEPPVLNSTTGQWLNSELLNLFLFHEMRPLEKSEEIHIIREKYGEPKDALLNIIELAHSLRSSNDPTMQSLASSLSTRQLLRIAARMHKFANDDAYDAVHRACLARFLPSIAKQALEDSLKKFNISPKKEGLDSDIRCIVDKDTVTIGATTVPRYKTSALTKVPDILFYDVPQHLILLETLVQDFILGQNLLLVGNQGVGKNKIVDRLLQILNRPREYIQLHRDTTVQTLTVQPMVRDGVVVYEDSPLVQAVKLGHVLVVDEADKAPTHVTCILKTLVESGEMILSDGRRIIPALQNDKYSQDAIPMHPDFRMIVLANRPGFPFLGNDFFGAIGDLFSTHSVDNPSVENEIQLLKQYGPNVDDKIVHKLVKAFGELRSMADQGLVSYPYSTREVVNIVKHLQKFPNEPLAIVVKNVFDFDRYSQEVFDTLIEVLHKHGIPIGTSSKNVALAKELPLPDLKLYSTWNIQGTCQTIPIQERFFKNKPVANPPQKTVTLDKIEARSAWFTELDSYWSIPMNDTSTVAALSVSPGLKADGSDDKINVLASNPLSLFIMSMDSDKLQELSLQGLISPLRGNRPLMSLANDKKGNILVHEETSNSLLSVDPVKGIAYNLQLSSMFDSASDKISQVLGNRSYTWKLRKDLIESHNQIVIFTPNNNKIEVMDLDKSSAFTMTLPFEIDSILLASPERWLIQSTQQDKFILQKSLSTSPCPNILRRVDQDDSGPYKIGSLLNCSKESLSNEMLGKVLNQKIESPNRIVATNNTYASIVVGFPELDSSNEVFSFPRNQRVHSFSIPIITQQGTIIRTIASSNVPSPALYEGKAHPGSSGYLEITDPIDKKLRYVPIPAPMKVSPVTQWLYDKELPLYVSVTSNQGLVTIDAGGCIRVWETSLVNLEKSLGAWKKMVGADGERLQITKERYSGLDVTAPKHGKVDPNNDPHVGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHTVHQLSDEEKNAVPEHVKKAAREMGLKVFKQRLNDIRMSEYDHEMYSQFSNAVQREVQALRVILGSLQAKSNERQWCRHQTSGDLDDTKLIEGLTGEKTIYRRRAEKEPDIGAPQLKPKRLKLVVDVSGSMYRFNSYDGRLDREMEACVMVMEAFSGYENKFQYDIVGHSGDDYRISFVDHTQPPADNKRRLEVIKTMHAHSQFCMSGDHTLEATKHAICTLAKEDTDESIVVVLSDANLERYGIRPEVFAKALTSNADVDEENALWQGFRMYGFEKYSSNFETNICSFGAQYNALKLNIDGNTYTPRFDTCNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKC6</accession>
    <name>A0A232EKC6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003817">
        <property type="protein sequence ID" value="OXU18809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKC6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="74175" checksum="A7B6239A945D6761" modified="2017-10-25" version="1">MNKYFGNPKNVASSARIESYFSQYKGSICENGPIREDKLLILTCRQIDSDIKLAQATLNNLKPHEMISRKNFEIDDNQHLHATERWKNKYVEDPIPNSLQTTLDSIIGDDVLELTGTGYTEDLFSEKHIKNKEKNKTTQNEETFDETTSLTSQFIEKIKKKTETSESFDISDYKSKQNDYYLPDFANRLSQLCKEFPCWTSVMNKYFGNPKNVASQAALNNLKPHEMISRKNFEKDDNQHLHATERWKNKYVEDPIPNSLQTTLDSIIGDDVLELTGTGYTEDLFSEKHIKNSYNKIDTNEVMNSNLNANESYLNCEANIDNQMSIESSDPLRDHSYCILETSGQELCINKSMENNQIPENNSNETKQNLIVDESREINKSDSFVNFTSNVTLSSSVNHEPLSNCKTLEKELPKRGTYVTPDPEIMIKLQKPQSNAKGKGVIRNSVNASLYANRAHILNSLFPCQNSVINCQGNLNDMFNKLMSEYTSMKELTTCQLCGFSNETKKCNIPIPSINIVQEDKYSTLEQALQEYFKDRSVYCHRCKKMSALLKKSSGSYLAIDTDDAYVLLQNSNMNITSDLREIPTSITLTENVYVLCGVIEFVPPVIPQGMGHYIAYCRKLNNTWKFYSSTLPNVTRIDHTYTVISTNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKS2</accession>
    <name>A0A232EKS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003720">
        <property type="protein sequence ID" value="OXU18957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKS2"/>
    <dbReference type="STRING" id="543379.A0A232EKS2"/>
    <dbReference type="OrthoDB" id="3176202at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001217">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU18957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="528" mass="60625" checksum="6F27F19E7A4E875D" modified="2017-10-25" version="1">MNFSEQNARSILPQFSEISRTNVTTSNYATSGNDDHQSIQNVFTTAADPNHVKQILINSPTKYSNALLNWSDPNTLMQLCEKQGFQTINIPAYSQNSTVLSVQSHNLPMRIIPNVYVPPTDNNFEKNDSNHLKNDNEEVNSNTLNSQTLQQQSLAVAEYLQKLQSTTLPITLQQLIKMQSEQTKKEKDDEQKNDQMQNNILNIPNVPIYKASQLQNDSQYINNDHSIIPLNPSDVNVHIEEQSENRNITQNQAQAQNNKMEQTTQSDPTTKPEKKIKFRAKTGEIKITIALDGSTLYCCPECNLAFAQKSEIEQHLQIHVQERKYQCKECGAMLKRKEHLDQHMRGHSDERPYKCPICQKAFKRNEHLTRHYVIHSGDKNFSCQVCQKAFSRKDHLNKHTQTHLGIKKPKLKKESGVHIELQQQQHQQHQPQQQQQQHQPQMMDSTPTVTTTTAASMLLRPDLNNFLKEGNLKQDTTHLLQHIHNLQKDSNLFSALKEHVLRDTSGLPQQAVNMNEILPQNTRYLMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL95</accession>
    <name>A0A232EL95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003592">
        <property type="protein sequence ID" value="OXU19136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EL95"/>
    <dbReference type="OrthoDB" id="7696912at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="288" mass="32013" checksum="9B1DB14956D7DE71" modified="2017-10-25" version="1">MKGKTRMKLKFNKLVTVVIKSMTVSKYSCRFIQSALKGARQAVKSVGGKKKVIIPRVLLLPSKIGRVLPFLIPLFAGLSATGAXKGARQAVKSVGGKKRVIIPRVLPLPSKIGRVLPFLIPLFAGLSATGALAGGAAGIAKAVNDAKAAQKNYEECKRHNETIEPIALGKGLHIKPYTSGMGLFMIPHISRDFRGVFMRNNLPLDGPWRNETAVVNLDDFQNRGTHWVCYRKRGPEVLYFDSFGDLKPPKDLMMYFNVKEVKYNYKRYQNFDSFICGHLCLYFLAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL99</accession>
    <name>A0A232EL99_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003599">
        <property type="protein sequence ID" value="OXU19125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL99"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="10632" checksum="F86B81AB0D9DE790" modified="2017-10-25" version="1">MCVCVYASSRQSASVNSIARAPVNSFGGRVCSAFHQLRSAAKHASLYITKSFDVTRACGLNPKSTTGNSRESRGKKNAFRLSKYGILTRAHAEIIHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELP4</accession>
    <name>A0A232ELP4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003520">
        <property type="protein sequence ID" value="OXU19275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELP4"/>
    <dbReference type="STRING" id="543379.A0A232ELP4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="136" mass="15445" checksum="1E8A5DABB9DD1063" modified="2017-10-25" version="1">MIYNNLNVIQALNSGESARDNNCDANKQRSSDHPEKCAGHQERGGKWIRRRQFYAAKRQQKWLNKETSRRLHETEKERILQEERARTEIGRSRSGGQGHDGLSRAPQPPQGPYPPPPPGTYVSVAGANVPERLLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELQ8</accession>
    <name>A0A232ELQ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003525">
        <property type="protein sequence ID" value="OXU19258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELQ8"/>
    <dbReference type="STRING" id="543379.A0A232ELQ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="1">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="9211" checksum="22E386F89DBD248A" modified="2017-10-25" version="1">MRQTFARNQLNLNNKQPLTTIQIRLADGSNVRSVGDLRRYITTTRPQYALREFSLQTTTKELAKENKTIEEANILNSAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELT5</accession>
    <name>A0A232ELT5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003501">
        <property type="protein sequence ID" value="OXU19319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELT5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="173" mass="19672" checksum="E86970E3CD9D6771" modified="2017-10-25" version="1" fragment="single">ANIEEYRRIILKNCTRSEASGAPGDRGYREYTTLLKKPDGSPSFQRSELQLRRFDDSLSLDERAIIDKVWIAREKLIRFQLAYSPESITRREDQSLMEEQNKMFLAGIDMLIKGLTLPASATVAMLQQHQQQKILAPATEPSQATLTESVNETAAPDQQQQSKRNQLTLAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMJ3</accession>
    <name>A0A232EMJ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003356">
        <property type="protein sequence ID" value="OXU19557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMJ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="171" mass="19591" checksum="8DA231ACE99FBD5E" modified="2017-10-25" version="1">MHRILGCEELLGSEWNHFRWVRALKERRRSTDSHNRITALRGMSGAAEAAAACVDCSGLTSPPSATIHVYHIVVEERTSLLGELAPPLPRGKETLCLAVIQCPPLSLSPSASSLFKFSPNLSSLSRERERERERERERERERERERVMCTAKFIAWANFSFVRSRLLRNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENQ2</accession>
    <name>A0A232ENQ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003097">
        <property type="protein sequence ID" value="OXU19985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENQ2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="181" mass="21025" checksum="CAEBBBFA7A324D3C" modified="2017-10-25" version="1">MYTTYTTDKRISDADSRHAVLSIKLGLCIHFVFFFAFYPLGTALASKKTWLIDSSGNNLENKWEITYYSLREMKVWNSCRACSIKEQNNSVRGKLQQAPTVLRSIYYTYGMSNGLNCFKNDFSLKKNAREHLRESPEFVKSIPSCYYECTYNVNYVTISYANLKVIICANQKQQHQQDIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENZ5</accession>
    <name>A0A232ENZ5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Caveolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_014350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Caveola</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the caveolin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003047">
        <property type="protein sequence ID" value="OXU20058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENZ5"/>
    <dbReference type="STRING" id="543379.A0A232ENZ5"/>
    <dbReference type="OrthoDB" id="5917823at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF19">
        <property type="entry name" value="CAVEOLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="234" mass="26702" checksum="1ABC8C0503F48035" modified="2017-10-25" version="1">MRSCVKDAFQCPAIRQNFTISGMEKPESSMGDDSRVDLEDRDPHRLNQHLQVIWEEVVGEPDGIRSPECAWRLSGHCFRLSRGCCYVLLSVLVAPIIALCLGLTFACLAFEGYVLQRRDRVPTTVLPLAYAYHCRQEHTSGVFIDACLLFRNVHTLLSFKSANPTPRFIHIWCIGPCLRVWRITCSATRNFCTALVQSVVRPCTDSLGYFFYNIRVLNQRLPDVNDHKEDVHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP57</accession>
    <name>A0A232EP57_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003005">
        <property type="protein sequence ID" value="OXU20140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP57"/>
    <dbReference type="OrthoDB" id="7693491at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="9016" checksum="074E3A01D1230EB0" modified="2017-10-25" version="1">MDYDNVIELQGFRDKEDKFLPKEVALVSLQRHVISHCVILPSHEFTELPCSLKIHNDYVAARYYGIHLFEGDITLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER79</accession>
    <name>A0A232ER79_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pupal cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002648">
        <property type="protein sequence ID" value="OXU20873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER79"/>
    <dbReference type="STRING" id="543379.A0A232ER79"/>
    <dbReference type="OrthoDB" id="8117569at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940749" description="Pupal cuticle protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16967" checksum="1395C08F864C2BFA" modified="2017-10-25" version="1">MRLFIVFSTLAVAVFARPGYDHHDVHSYQPYHGPLAPLAHDGRVVDTPEVAHAKAAHFHAYHEELSKTAHHGPTLPEHHGGYELAHHGPVAHVDYHHAEPVHHYHGPPAPLAHDGRVVDTPEVAHAKAAHFHAYAEELSKVSHHGPDLGYHHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERW1</accession>
    <name>A0A232ERW1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002545">
        <property type="protein sequence ID" value="OXU21089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERW1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="147" mass="16978" checksum="6A980038B6E66C04" modified="2017-10-25" version="1">MTVVRVAICLSHGCTPLALLRIEDVMDNPSVKMMIRMLALKKVYHPSIEMKDLIIINDYFSLRSYYNDCLEEIERLISTRFIRTCTFIELLTKSHKNNYQAQLEQESMIDEAFYGTLAYLLIRNLTGLKKITLDLKSGSKVTFFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES57</accession>
    <name>A0A232ES57_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002494">
        <property type="protein sequence ID" value="OXU21184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES57"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="20264" checksum="3D50327AE0089749" modified="2017-10-25" version="1">MQSKTALRSILKKSQSNDDITTNEGSVPTTTYTEETAPSESKPVVDNSTALLENKPVLKNPLVDEEVSNGDMKVLEDVNDVRRTVKYVPKPRIRKTQMRAIQKKHDIEGWYAHIGCYNYKRKIFFNFCLDGQLLLKFWKYASLQRQMTNLVTSNFLRSKYSTSYTRSLWRTPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESA8</accession>
    <name>A0A232ESA8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002484">
        <property type="protein sequence ID" value="OXU21207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESA8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8133" checksum="DFD82DF404A53CDF" modified="2017-10-25" version="1">MLIGLPRSLASKFHNYVNRYRDFKIPGADPRSAFLRSDLLTHWRLQLILGEAAVFASVSVWSVPNSSNTLGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET55</accession>
    <name>A0A232ET55_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002331">
        <property type="protein sequence ID" value="OXU21533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET55"/>
    <dbReference type="STRING" id="543379.A0A232ET55"/>
    <dbReference type="OrthoDB" id="6343844at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="594" mass="69427" checksum="632B78871CA0C4CF" modified="2017-10-25" version="1" fragment="single">VKMSDQEALSSTNCSSDEYYTIEEDSSKSETESISTFCDAKEEDDQSQYSLTLAIKDIEDKLSDVLIENVKLKNILKQKDDAIRKQFNTIVILEREIMQICENYKIKFVEIKNLVAQSKPDNKNLYAMISSSDVQDSSINCDSSDEGCNGLIIQSEVTTNDELVGCKADSTEDLMQKIKEMTTSHAQFQSKLNEVEKQREADLDQFNKQLENRQNELELLKHQLVLPEKSKLLKLINEDYKKKLERKYLIEVIKLLEQKLQISGINCGTQIERNVPESDSQNEKCREFIECFIKQCVQNTDLKQFETDCKRVVQTFKNLQLSCDDIFIENVTNKKNDAICDYRKILIEEQLQRIKDERITLMIQRQFLKVLADYNKVVTQLEMLKYKNSRLSELNEADSSTQNFAMIEKCLFEEKKIFDAEIKKMSENRLNIEKEEQSIREEWELLSVERAVLLVEKDELIEESRRLEHEYSLLKQKTAAFNEINAKQRRDVALEEKLRQTTDELEGVKVELQNKHETIAKLQEELSKLNNQESEVTAYKLQAEMQEAEFLAMREAERNYLQQIENLSTEIYQLREENCQPAERNQNANNEGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET57</accession>
    <name>A0A232ET57_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_011579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Binds clathrin and phosphatidylinositol 4,5-bisphosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002327">
        <property type="protein sequence ID" value="OXU21545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ET57"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16985">
        <property type="entry name" value="ANTH_N_AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000017">
        <property type="entry name" value="Phosphatidylinositol-binding clathrin assembly protein LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="12">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="567"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="817" mass="86968" checksum="5468239E9FAFEBAD" modified="2017-10-25" version="1" fragment="single">MAGQTINDRLLAARHSLAGQGLAKSVCKATTEEMIGPKKKHLDYLVHCTNEPNVSIPQLANLLIERSQNTNWTVVFKALITVHHMMCYGNERFTQYLASSNSTFQLSNFLDKSGVQGYDMSPFIRRYAKYLNEKALSYRTVAFDFCKVKRGKEDGTLRTMNAEKLLKTLPVLQAQLDSLLEFDCSANDLTNGVINMAFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKQCRDALDLYKKFLIRMDRVGEFLKVAENVGIDKGDIPDLTKAPSSLLDALEQHLASLEGRKGSAANTPTQSASNRTNVKSGVSALSSTSTAFGTAASNQRLEQTGNGHIDEALRQQALAEEEAVMNQYKAKVQSPTGGPSTNPFLSSPTNNASQPIVDLFGGAPATDGQQKASDDLLQLAGNPFADMFGAPAQPAAPVQPAPVQNNMWMTNGNGFSVAPPATNNFVTDNNFSSVFGNQDQQAAAVPGADIPNPFASDFPSSAPQVSAGFDQQQQAAAAAQYQQPGVDSQTQPGAAGDLFSASSGQTADLFGADAAVARAPGEAGAGGFLGDQQQAXXXXXXXGTPRSASPAQPNKSAFDDLNDSIRMALGGSPSRPAPLAAQQQQQQQQQQAQQMQQQQGFAVFDMGQQPMMPQGGSMIGYGVAPSQAQLPMGYGSPAKQPMADFDDLAAILIPISSVPVASNISAAGQPVNAATAAAAPGKVLTGDLDSSLASLAQNLSINKSAQQQVKGMQWNSPKNTAKSGGTTVWTPQPMVATTGAGYRPMGQGMTQLPAATTMGFPPQPTPLVSFSFYEALTSSPFLFLFFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETA2</accession>
    <name>A0A232ETA2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002300">
        <property type="protein sequence ID" value="OXU21588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETA2"/>
    <dbReference type="OrthoDB" id="6740702at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="225" mass="25866" checksum="F7CEBE5A61960437" modified="2017-10-25" version="1">MIDISVRSVNFARVPGGFSLCPVNNFLYNDLCCLISGLLQSNVDFEIDESFILTVTLVNVMIVIGETFMTYKKSDRPEENEIWKTVRDGRRCLQKVVLIFCFLPQTASFGNGEPPFYDGSHLDTILNLTGAAGNRFFCNHCNRHGCGNWCNLCHKKYNVNKLCYVQPFGREINVSNIRKTPKKKNLFIFYDFETRQDSPYRDHDSIKIHVPNLCIVQQVCDNEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU38</accession>
    <name>A0A232EU38_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="16">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_015960</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of the anamorsin/DRE2 homolog, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="16"/>
    <dbReference type="EMBL" id="NNAY01002170">
        <property type="protein sequence ID" value="OXU21879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU38"/>
    <dbReference type="STRING" id="543379.A0A232EU38"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000015">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 16" id="KW-0288">FMN</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0521">NADP</keyword>
    <keyword evidence="14 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="710"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="953"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1056"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1094"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="250"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="427"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="461"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="557"/>
            <end position="558"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="563"/>
            <end position="567"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU21879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1122" mass="128337" checksum="65A32904206B80E8" modified="2017-10-25" version="1">MTLASESGQKKRSKLLNDLSMRESRRSLAEKQWRRLKPLDIFKFSFDLLKMAGPRITILYGSETGTAHDIAEQIWKRSKRTGLKSSVDAMDEYNIQNLINEQMMIFVVSTAGQGDTPLNMKQFWKCLLRKSLPVDFLSNLKFSVLGLGDSSFEKFNFAAKKLNKRLIQLSATELVPIGLADDQHDLGIDAVFSPWLEDVFNKVCHEFNVPKGSILSEHEIIERFRVDIIRDQKPDNSITDIYLYEAEKNKTLITSTIIENIRTTASDHFQDVRLIKFKVPEVDYSPGDIVYIKAKNSDEQVDKFFDVLNRNGVDVHPDMLIQVSEKEIKLPTVLEPMLTLKQIVQQYWDLNNKPKRSTLHTLSLISENELEKEKLIEFTTAAGQEDLFNYINRPRRNIIEVLNDFPHTTSKLNVKLLFEIMTPVKPRAFSIASSSKQTKNEVHLLVAVVRYKTKLVDTRYGLCSNWLATLKPNEKAVFWIQKGTFKFDYEKPMILVGPGTGIAPFRSLLLDKAAKDGDLSSCLVFFGCRNEKKDYHCEDDFRLLTDKYSLKLFCAFSRDQPDKIYVQHLIRQQKELCWSFLQNSGNIYLAGNCKNMPSAVREEFVEIAKVCGKMNQEQAENYIRTLEKSERYQKMAGSYTKKEFGIGPEEQTLLKDSNGMRIVPVKGAEPVRLSPGWEGTGRPDDELNFKGVTMDQADLEINPPRDRLNIVWLIMILHGIGALTSWNMFITAKGYFVDYKLSKDYTNEDLYYSQSFLSYMTLFSQIPNLLFNWMNIFLPLGGNLTTRIVWGLFIQVIVFIITIILAMMDTSKWPGIFAIATLVSVVVLNTANGIYQNSVFGLAAKLPGKYTGAVVLGSNISGTFTAVISLCAKYFAPNVRTSAIYYFITALFVLLACFDTYFALPINRFYRYHEYLNQKEANKKKLEYSSNRSGSSKFRELWEAFKQCWPQCFNVWFVFFVTLSLFPNLQVNIKRSDPNFIVPEAYYDNIMCFLSFNITAMLGSSLASWFQWPSKRFVIIPILLRAAFIPLYFVCKYVPDKITADQRSFILIENDWIYLVIGLLMGLTSGYFSSVAMMYCSNTVEPRHASNAGMFGAAFLITGILSGIGFSMLMPWFVSVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV31</accession>
    <name>A0A232EV31_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_015574</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002059">
        <property type="protein sequence ID" value="OXU22209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV31"/>
    <dbReference type="STRING" id="543379.A0A232EV31"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15525">
        <property type="entry name" value="PHD_UHRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20388">
        <property type="entry name" value="Tudor_UHRF_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021991">
        <property type="entry name" value="TTD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF45">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12148">
        <property type="entry name" value="TTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="15">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="287"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="YDG" evidence="17">
        <location>
            <begin position="381"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="651"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU22209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="721" mass="83126" checksum="D8FAF0A3A7900514" modified="2017-10-25" version="1">MYIKIRNCNNFEELEISIVKSATIAKLKKEIEKQLAINSELQRLYFSGKHLEDENTLYDYNIRKNDVIQFMVKSDKMVTENLESPKVDKNKNDVNYEEKKEKEMEIVEDAVSDCYAVGDAVDCVDLKYGAWFEATITRICYKNKKLVYFVKWDLVDYAQPFQVDEDSIRPRACRIIPENDLVVGQRVMINHNLDDASQVGHWYDFEIKRISAAKKNRAFFGTLFLGNNAQSHIYRTVILNSEVYAIEKPKPLKDRNENDSNFISNIRRIVAPECSKCFDKLDVKCKECGCKVCGGKDNPDQIILCDECEDEYHIGCLTPALPKVPEEDWYCPRCKTDDTEIIKMGEKIKKRQKKNGYKKNYKIMYVKKEKRYPTVRKDHRGPIPGIEVGTTWWNRVKLAEDRVHMPPIAGIHGRESDCAYSIILSGGYGDIDNGIEFIYTGSGGRDVLGNKQNSHQTLTRANKALALNCRAKFNDQEGAVATDWRAGIPVRVVRSYKLSKYSKYAPSEGNRYDGLYKVVKYYPEYDESGFRLWRYLLRRDDPLPPPWSPEGKRRIAELGLKMRYPDGYEKKNLEKKIEKPEKKLSIRNNANEVKDTQPKKKQKVEPYHLDSNVSELINKDVVNAKLWQACKSYLASGKACFQNQVSKSLQCVCCHDLVFKPVTTPCAHNICQSCLKKSFVAGVNCCPTCRFKLKKNLKLPINKDLAMILILLFPGYERGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV73</accession>
    <name>A0A232EV73_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002040">
        <property type="protein sequence ID" value="OXU22254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV73"/>
    <dbReference type="STRING" id="543379.A0A232EV73"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1520:FF:000001">
        <property type="entry name" value="Hemocyanin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF4">
        <property type="entry name" value="PHENOLOXIDASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00209">
        <property type="entry name" value="HEMOCYANIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00210">
        <property type="entry name" value="HEMOCYANIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="10">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="544" mass="62706" checksum="8ED0B31BAB399A24" modified="2017-10-25" version="1">MHLHTQNAIEIPLDWTATDADPEHRVAYWREDVGINLHHWHWHLVYPFEGPPVAVQKDRRGELFYYMHHAIMARYNIERLCNNLPRARRLMNLREPIPEAYFPKLDSMVAGRAWPARPAGFVLSDVNRAADAMRFDLSDIELYRDRIMEAVHTRQVRNGKGGVIQLDEVTGIDILGNMMEASILSPDPAYYGDVHNMGHVAISFAHDPDHRYLVDNYKIISRYRAFSDLVGFQEPFTIMGDATTAMRDPVFYRWHAYVDYVFQIFKDSLSPYTVEQLVFPGINVTDIRINTPGANPNTLNTHWSKSDVDLSRGLDFTPRGSIMARLTHLNHDDFSYNITVNNSNNKELIGTVRIFIAPRFDETGRQFTFHDQRMLMIEMDKFTTQLKRGQNVISRESVDSALTIPFEATFRNVDLNRPSDQDIAAYDAFNFCGCGWPQHMLVPKGTKSGYPMDMFVMITNYELDRVNQRDPTGCREGVSFCGLRDLKYPDLRPMNFPFDRLGRTGVGSLNDFLTPNMKVQQITVRFSDIVKPRQPSRGQTVIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVV1</accession>
    <name>A0A232EVV1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001945">
        <property type="protein sequence ID" value="OXU22485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVV1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8802" checksum="E77DF37E3490D3F7" modified="2017-10-25" version="1">MMLPFMAIFLLEPHFLGRTAKGLLSSEATTLRTSPLRGDQATKQDLSCFSLGLTFYQFARLRVRKSRSRNDSLNHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWC3</accession>
    <name>A0A232EWC3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_007717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001884">
        <property type="protein sequence ID" value="OXU22648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWC3"/>
    <dbReference type="SMR" id="A0A232EWC3"/>
    <dbReference type="STRING" id="543379.A0A232EWC3"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12685" checksum="17AFAEE6F81E6D95" modified="2017-10-25" version="1">MATRIKQILAKPETREYFMSTHFWGPFCNWMIPIAAISDIQKDPKFISGKMTLALTCYSLVFLRFSVKVVPRNMLLFACHCVNLSAQLTQGYRFLRYQSSLKNTRAIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWC6</accession>
    <name>A0A232EWC6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001882">
        <property type="protein sequence ID" value="OXU22654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWC6"/>
    <dbReference type="STRING" id="543379.A0A232EWC6"/>
    <dbReference type="OrthoDB" id="6284251at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037689">
        <property type="entry name" value="BAG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12334:SF6">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21030" checksum="413972291CBDE1AC" modified="2017-10-25" version="1">MSSPLPHIIESMDDFGGGKPKDRLVSILDRIEMHVEQLRKDAIRIEEEKDTLLTTLDTLRNNDVVVELEDTDRDDVLRYAERLSMRCLTIDVLVKVQRDHTQQDALHQVNGLIDSLVIGLRNDPSGTRQRCASFMNACSSQGMGHSDKTFETAILGCTLDDQKRIKKRLQGLLDYIDKVHTITLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWN6</accession>
    <name>A0A232EWN6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001846">
        <property type="protein sequence ID" value="OXU22741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWN6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="25" mass="2813" checksum="4DBDC92BC64E723F" modified="2017-10-25" version="1">MISFSETRSVCCLRKIPATNTAIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZF2</accession>
    <name>A0A232EZF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01001465">
        <property type="protein sequence ID" value="OXU23876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZF2"/>
    <dbReference type="STRING" id="543379.A0A232EZF2"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF63">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="386" mass="46106" checksum="32A9DA269C6A538A" modified="2017-10-25" version="1">MLTFPVKGKSNHNINVLFSVFYCFINYFQNYIKISLLTLCFASFCLLIVNSPIKPNRFGNQNKVVIAINYHHKKKCEKQAAATAHYKLSSESHSRVKEQFQKRKNRIEYLCKTLDNDTINSTMKTALSKIVIDQIHGLTWCPVYKSASTMWMKNFAVLSGYPVTISLHSGHDKNLDFSYIVKQKFQRSDSVEQKLKQISNTTKFIIVRHPFERLLSAYRDKLEHMKGREYYYRRYGQYITHRYRAKYSNLTHCEPSFTEFLQFIAKEKRFDEHWVPFIDSCQPCSINYDYIFKFESLSEEYNYFIKERNLWYYLNYSSNERKSTSFQGITDDAVAEKYFEQVPAALLLRIFDIYQLDFRLFSYSPAKYYFMTKDANQERYNFLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZZ2</accession>
    <name>A0A232EZZ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001475">
        <property type="protein sequence ID" value="OXU23837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZZ2"/>
    <dbReference type="STRING" id="543379.A0A232EZZ2"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="9796" checksum="8DB2012FF9FE8119" modified="2017-10-25" version="1">MSQKSKVINLYKTLLFMGRDYPKGFEFFRSTLKKVFEKNKNETDPEKIEKMIAHGNYVIKELEALYMLKKYRTLKRRYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0G8</accession>
    <name>A0A232F0G8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001382">
        <property type="protein sequence ID" value="OXU24165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0G8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10313" checksum="E5C2B9FF58D8E2F2" modified="2017-10-25" version="1">MAARGAAAYIHIRLFSRMRTARLGSEFSLLATTPPRTRQGQQHRGAHTPDKDSISRARARQGQLDSRRRRTRLAIASLSGGGADCVELLRGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0J0</accession>
    <name>A0A232F0J0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004464</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001403">
        <property type="protein sequence ID" value="OXU24090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0J0"/>
    <dbReference type="STRING" id="543379.A0A232F0J0"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU24090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="321" mass="35494" checksum="0466738F9A8D1B50" modified="2017-10-25" version="1">MVSVLNTVDTGHEDMIHDAEMDYYGLRLATCSSDHSVKIFDLKNGSPSLVAELKGHQGPVWQIAWAHPKYGNLLASCSYDRKVIVWKELSEWTKIYEHTVHDSSVNSIAWAPHELGLILACGSSDGSISILINNGDNWETQKIPNAHTIGCNAVSWCPVIEPILDNASQQQKAPVKRLASAGCDNIVKIWKEEGDKWIEETKLEAHSDWASFISCLSKLVRDVAWAPAVGPPRAALASCSQDRRVIVWTSTDYASWTPNILNVFDDVVWNVSWSLTGGILAVSGGDNQVSLWRENTEGQWICISELNKGQGNINNTDQRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0T6</accession>
    <name>A0A232F0T6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001310">
        <property type="protein sequence ID" value="OXU24396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F0T6"/>
    <dbReference type="OrthoDB" id="5797019at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003913">
        <property type="entry name" value="Tuberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01431">
        <property type="entry name" value="TUBERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1534"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1796" mass="202576" checksum="FE42A9BC4B12E683" modified="2017-10-25" version="1">MSKMRAQDKDNKTFPDKLRQFFRINKGNFKSREDITLTNGIEREISSDSPVHCRTKVIKDLSEAVLNNQWEDCAAERLWFLVQDLLAPEIPREHRHITLNFLKCLIQGQYSRLSSLMRVKFFNVIKEHDIPEDIGLRLELLQSLTENGKDIIHLEEKMGPFLLSWMPIVTGADGKRGAEFLSLLVNVIKFNSACIDEDIVSGLVQYICHLCYYSNNPEVVSASLEALDAIVCYSKLQPDSLQTFIIALCRSVNVETYCQISWKIMRNLLGTHMGHSALYKMCSLLQEPNFQKDVRLLRGAVFYVNMGLWGSHRIPKLKCTPSSVLPSFHQALLCNHPIVMYEVTLSIQRLVNKYGIELEQPTWGIILDIIEQVIVHTENSNQPATKQVSTSLHETINSIEYLLDNNSYNGNVQKFYELVERCSDTRPEASVLKLIDYRASMLGPTCYQWQSKLSSLIDRYYKFETRTNIRVKVLDVLTNVIQMNRSRYEDELIERIIVPHLQHVELDPDVTIRNFAAHVLVDLCLECDTKRCMDLLDILDRIINRPFQLETPVQVDADIKDVKTSVVGVIKILTQKVYRLPSLHAIRAYQVLVNHLELHYQDHKGIFQEVYTIRYLIFECFLKARANGLGHVGFPEQATGTVTRYSPYLVLENTSFNSSSSGTSPPPASPVPLQSANCQITNISLAHACKAVTTAVKQEKNVQVLQLILKELPQLLQNRALILSRHSNDVGSLAIALCNMIDDKNFRTEFRTEIFPVLAACTSYHAHFDLNTQQRLIKCFEEGLRTTCAAQCVTSLMTCALEMRDIMSKLVSNVLLSLSKTSDTVNMAIPILEFLSIEQYMSIFAIILPYTKPTRYNHYTVSLAHHVIAVWFLKCRLQLRRNCAKVITKGLKSNAKMLLEEGTISAKPDIGLSNEDSSNRKRSSSLTEQGSRARRYVRESRTLDLKPPVDQALQNFHVELTETCIDLMARYSYSMYSARPKRLLAADFLLKDGNSVTWILGNKLITVTTSGCSNKTMRGPLCDNCWAACKATPDQTRSSHSSLLRASSAEGNKEDKLSRQSSGGLASSSANTAANSPTEENKRSLDDSDTYKTKESGVDNLDRGEQQHQPNSETYKLEQMMNTDKQEEHQPCACWCQGWAEIYVRRPTGDMSWIMRIQNSMHEVSPYELPLDNITALYMPTTDILPQKSQDLASEFSEDEIPDTTEKTLEPIQAEANTVVKPSTSSTSGPIDIPGSPARPSPSRPSPRDSLESLEEGEEESRKSRNPVRRSNSSPEMSSNWKNPFLNKDKLNLPSAERDDVNPDLDVKSDTDLKKHIKSTYTKDMRVSCEAIPEEISGMGTTPPSTENTGEHPSGLLSQRSYPGTSQVSQTTTTVTSNTVPPSPTAGQPPANLLTSQSQLASKPPQSPTQIYSRLSNLDSSHNRQSWVLDSKPPIGRNHFIEKLREDKADPSSLPPLSFRDRGHTISVMSPAKIRRTNSPRIKDSPSQMNLPNNRSGINPSYVFLQLYHSAHFGQSKEKPLLVPQTSALLQTSITNLDRIQPYETHKIGILYVGPGQAKNETEILANQHGSLRYAQYLQSLGTLIRLKDADESIFLGGLDRNGENGNFAYIWQDDVTQVAFHVATLMPTKSSDPKCTSKKQHIGNNYVTIVYNESGEEYDIKTVKGQFNYACVIIQPLDHGTNQVTVQARDELSKHIGHSEPKIISDHNLAILSRQLALHANLASMVCSSLNQKDRNPYASNWLERLRHIKRLRKRILEEQARKNPDDDSIKKALEEEDKSIIVDDLVQDFTDFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0V0</accession>
    <name>A0A232F0V0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001408">
        <property type="protein sequence ID" value="OXU24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0V0"/>
    <dbReference type="STRING" id="543379.A0A232F0V0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="316" mass="35225" checksum="BE049AC10CB0B16C" modified="2017-10-25" version="1">MDGNDIEPVEGISYSNIYDSFDSVVTEMFDHWGLGSCRTRNSTTRVHQVSILRYESAELSDPKAPVGYDIPETPTDARILNPHNKGTEDPMAVSIPLLRSIAKNDETSLGKPDHHPGQIQNNVSATANHIGLKLPSFPPLSQPDMIRDDTFCNSTTLADKNCIDNECACTHVLQVKLNRVVELVIVDEAMKALAEQVSVDLVKKLDREGKIKRNLNQAPLEDTVEVSTNGYTIVRFHATNPGQFNYITLSSTPINIHATVIDTPKVCVISISGYWLYHCHVDRHTNIGMALIFKVGKQRLSSRPEILSDLWRLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1N7</accession>
    <name>A0A232F1N7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004588</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001328">
        <property type="protein sequence ID" value="OXU24347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1N7"/>
    <dbReference type="STRING" id="543379.A0A232F1N7"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="RF_methyltr_PrmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Release factor glutamine methyltransferase N-terminal" evidence="14">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase small" evidence="13">
        <location>
            <begin position="158"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="350"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="444"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="558"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU24347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="656" mass="74287" checksum="F1842107580C7153" modified="2017-10-25" version="1">MTRLISKRCINLLTSTSPIPWTKISSNNELGKNLPALKLPVLFMCNNCDDENKKNTIAYVVKHWQERFLQEGIAEPIESIEHIVCHVIGSKKITDLINHHERVLDKEQLEKLELLCECRLSRMPVQYIIGEWDFRELTLMLEPPIFIPRPETEILVDFLLTRISDSANKNNNLLEIGCGSGAISLSVLHSSQNANIVAIDVNPRACELTIRNAKNLDLDMRLTVLNAAIQKDGKIEVKKAYGTNKEEVDFSKRKFDFIVSNPPYIPTKSVFELQPEIKLYEDIRALDGGDDGLKWIEPILKYASEALNVGGYLILEVDSSHPERIKFLVEKYYANQLKFKHIHKDYCNKERIVEILKINSIAGMCSKTTVAPLDRIKILLQAHSNHYKHLGVFSGLREIIHHEHFFALYKGNFAQMVRIFPYAATQFTAFEIYKKYLGNLLGHRTEADKFIAGSCAGVTAVALTYPLDTIRARLAFQVTGEHVYTGIIHTAVSIFKDEGGFRALYRGFTPTVCGMIPYAGFSFYSFEKFKYLCMKYFPTVLCNKCDKNTGGLVLTIPGKLLCGGVAGAVAQSFSYPLDVTRRRMQLAMMNPDTYKFSNGMVYTLRVVYQENGIVKGLYRGMSINYLRAIPMVATSFATYEVMKQLLNLDTGLKIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1Q7</accession>
    <name>A0A232F1Q7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001206">
        <property type="protein sequence ID" value="OXU24736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1Q7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="83" mass="9233" checksum="473E3BF338D10CAC" modified="2017-10-25" version="1">MSYYFRERPRFGERFRGKSGDELLQELKQQFGDDMPFFETTSSPSAARGSSPGPNSATAGSTPSGAGRTRDPFERHTSFPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F233</accession>
    <name>A0A232F233_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001191">
        <property type="protein sequence ID" value="OXU24794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F233"/>
    <dbReference type="STRING" id="543379.A0A232F233"/>
    <dbReference type="OrthoDB" id="7635274at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="324" mass="36590" checksum="F1AF92A888BB2D46" modified="2017-10-25" version="1">MLGADSSSAPQRKQPRWIEVETLEPIYSVLGSHKSGSSSEGSRRQPEVDIVISSKTATARQRFPTCPRKPPIPPNYRESRLKQQQQQQQHQEEEEEEAIYSVVNKGRAVLGSVEPEGSSSRREELENWLRTASRERGAMFNSSNNRDDREWRREGGVSTPRGIVGLVGPYRIHSTPLDDPHRQYILEEEELVEEMVDSVSETASRSDLDQPNWRVVDERDDAPACNDEDDNETLVPDESEDEKSPRVAKEEEVKVAEKSPISENWKLRESTTILSSVKYGKQERAVDVPDGASAISAASTVAKAKAGKRENELSRNSPYFRIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F324</accession>
    <name>A0A232F324_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_004659</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001171">
        <property type="protein sequence ID" value="OXU24890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F324"/>
    <dbReference type="STRING" id="543379.A0A232F324"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06907">
        <property type="entry name" value="M14_AGBL2-3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000011">
        <property type="entry name" value="cytosolic carboxypeptidase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF45">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE NNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="306"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="596"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="690"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="966"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="979"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="994"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1023" mass="116226" checksum="6C957FEDB680A3B3" modified="2017-10-25" version="1">MEYVVSGKVKDLQAALFPVQPIPGNSIASQCLQSRCGIERKDLDSVLSLTSGFVRCRESKETFQTLLVDSNLIGLDAVTQEARWPTECQVLPDRVRHVEYSPAEPEPFYVPTGKEPRPKPIGDESGTIVYRYCPANATNYFSRSCIGGSTVLSLDAPSTIEETAADCVTQSSGTDLCFESRFESGNLGKVIKITDTYYQLHLRKDLYTQRHMQWYYFRISNTKSGTMYRLSIVNLCKEDSLYNEGLRPLLYSTKDANLKSIGWRRCGENISYYKNDSSDEEKEKHTLTFNIYFPHDQDIVYLAHCYPYTYTDLQEYLAKIANDPVKTRFTKLRLLCRSLAGNGVYYLTITAPTANDEARRKKGVVITARVHPGETPSSWIMKGIIDFLTGESNQARELRERFIFKLVPMLNPDGVIVGNNRCSLSGKDLNRQYRTVMRESYPSVWHTKLMIRRLMEECGIAMYCDLHAHSRKHNIFIYGCESKRAGCPGKLAEQVFPLMLHKNAADKFSFENCKFHIEKGKEGTGRVVVWLMGIQNSYTMEASLGGSKLGSRSGTHFSTQDYEQIGKAFCETLLDFSDNDPVKEKLRNKIIARLAKEGSSADEPTNIELTDYSSDEGDTSDSSSEEDKYNNEMIQRRLNSCTEDRRYLCVPPPSPMLLKPATADPFRKMKKPKTNLPRTVMMRRKAMRNRKAMDLPTTDPGSDLYFTDSGDETNFRSSAETKEKDSDDETRFYGKENQDEKKSDLDLPLIVRPRSLSLGEEIISADLVRKNKRRLRRRRLPRPLRNLSPVIQKSQDMQIKLLSLRRQIWTGMGNYEVKNEESVEISLTNNYPLSWGVSKMACEYQTDNEALLESCSRKLEELNYNKQNDSKKSKKKARKKSTRVIEIPPVINIEEENRQALKKKKPRVKRQRAVKSSLEPLDNNAIVLTSDGLDSLKLFGTAKLPKVQSKQKSESKRKLNKAVLAATITTSKMKPKPPVDSVGDSSSSENSPLARRKSIKKKNNITAGKKRIQSAVAAKKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3B5</accession>
    <name>A0A232F3B5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001156">
        <property type="protein sequence ID" value="OXU24943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F3B5"/>
    <dbReference type="OrthoDB" id="6782661at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1581"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1619" mass="180690" checksum="C859ACCBABEB79A5" modified="2017-10-25" version="1">MMLTKEDCAENMEKGEHEYEPIGQPVMRMAISQHSMSVRMVAPVVKITDTDMIPAVDSDDSIDDRYRFKQRALILEGDVVLPLDGRIEDSAMDGRNLGDQTIDTSADELESPQQLQDRLEGRFQMSATPGAESRTDAEINTSQVESSMIEELPLRRGARGLQQRLKSSAGKIRSRFKNIQKPTFSMPHMPHRQAKSEKPTTVATTTTTTTTAEKPPASPRPADQKASRMERFRMALPERPRFSLPDKSKFHLPDRSKFHLPERPKFNIDRSKFQMKKPNIQLPKSLSRPKRSASQRGTLSREQSQASNADASSSTSATRRNIFDFSTYPRPKLFERKSKAKAEYVTSSPKESRAQSTESSTFPRANKSSLSLSARWAQRFGETVKGIHHDDSEPPVDRSKPWRHPSLEEPRLSLKPQTSEEEEEEEQQKLPWENNERRTYDAEDEEESREVSYGDRSATKAPELSFDKEPVKDPRLYDEQLMSRIVAEEPKKKVRLVEEDDEASLPDPEAEDEHHTYHPKELFDGSFPPVDPREFRVVRENSVDLSEDEGSSMRSDREIQQSSGSSCERRRRGVIEEIDSDEFFLREKGISQENMRFTLISEIRDALRPRVSAEIEEIIPPQRPKRTRSLRKRRDESLDSYDATPPPEKPKRERSSLRQSRESFHTQPSLERVNSLSRHRIVYQTETAPMSQTKDDMASEPLDDIVVVKPARRKSRSSLRSTSQSRLPPEEQNIVLASEIPTQVPVPPVPRRRKRLRRDNTNQSSSLSVRTSDSALCNGFHDTGSLHRSHERIPPTPPPTPPPPSHPDELDYIEPAAPVTSHPPVPPKRTRSHSRTASLAPEDDRTSHGAESLPGDFGYADGDDIPVIPRDSSSREPSLPGYAVIEKREKPPRPPPPRRKRQDKFATAPRPSKNGGPKRPLRAYSTLRPAKSDTIRKSVESIPFMDADYSLHDREPQPVHNDDDDADDDFHKDLRSGEVLSKMQGRPLPAPPRPPRHRRVDHQTRRSLPREITPDFSETVASTQTDPLPDDLVIEEEITSAKLVVTPSRHGSSQVLISTERVPSPTNGSYKSLSSGEPKTPPIPPLPSSVQQRDPVGTQAKDTNESEYRVPSTYEPRRLDPSQLEMLRSALFSSEGPLRIPSLEVGDLKVERLTVSQLEAYKVAASEIDAIVVSATELSNRGDTEAGIHPSLLQELIAIRNQLEAVAASQPQSRPQSAMEDACTATSNERIDMPLEESSRAAERRRSFTRERSPLLVVEQSLSGQEATKEMGRTSFPLSGSTTDLTLVASDSPSVSEVTTTFISTEATEEPVITITEAPVVQPSLDIATDDKLSSPRTTSPESRLTRSSSPSRSRSSSPSRGRPGVVRQTASPVKSLPPVISVTPDNIVTPTSTLPTGDNDSNMPLRHVTSSGVQPQRAVISYQSSNEPATTPSSLPPSRETSQSPPPPPVTTLARESSRSPPPPPSSAPQAPTRDPDVQTRFIAFPTSQIPASFFALADPPLSSSVTDQQQHQQRRDVEVEPSIADMSGQLLRALRHAGTRSLRHFVDSVVSRFASPDQVEETGVTSAAGALSEEKVRRIELAMCALLILIAGLIILCICTPRTVTHHHHWDYFNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3J2</accession>
    <name>A0A232F3J2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001124">
        <property type="protein sequence ID" value="OXU25048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3J2"/>
    <dbReference type="STRING" id="543379.A0A232F3J2"/>
    <dbReference type="OrthoDB" id="5867217at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.4.10:FF:000009">
        <property type="entry name" value="GG11699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF2">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="75"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="162"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44817" checksum="3F225876A604A3D7" modified="2017-10-25" version="1" fragment="single">MTIEQTCAEEKIRGTESNRAPQPACFRSANYANATKACELSDMDRLTVAGSGALEPAKGIDYLENHCVDEPVKLCEFKKINGRILKTVDSVYQDVATAEECRELCLNSPFRCHSYDYGDTGDMVCRLSHHSRATLSDIQEPYLDVPEASTYELSSCYNVSIDCLAGDMVARIQTSKLFNGKVYAKGSPNSCVQDVKGALEFELRMGYDDLECNVKQQGLGRYLNDVVIQHHDTIVTSSDLGLAVTCQYDLTNKTVSNEVDLGVHGEINPVITEEVVVDSPNVAMKITDRSGNEAIPSAEVGDPLALKFEILDPNSPYEIFVRELVAMDGVDSSEIVLIDSRGCPTDHVIMGPLYKSSSSAKILLSHFEAFKFPSSEVVQFRALVTPCMPSCEPVQCDQEEESTGELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3J9</accession>
    <name>A0A232F3J9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase MARCHF5</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Membrane-associated RING finger protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Membrane-associated RING-CH protein V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">RING-type E3 ubiquitin transferase MARCHF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_000437</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001051">
        <property type="protein sequence ID" value="OXU25334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3J9"/>
    <dbReference type="STRING" id="543379.A0A232F3J9"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16701">
        <property type="entry name" value="RING_CH-C4HC3_MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000262">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="22">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU25334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="405" mass="45606" checksum="87809F755C9C269E" modified="2017-10-25" version="1">MSNNSVPHASYGLDPQGRLVRIEAGSSNPSISRLSSLEETLRRLSSNFRQDDLHDFDRDEIRTISDLTDPELTSDMTDGASSPNQTTASIPQLSSDDEYVLNFGGFSTLCNNYSLNKFSYFSKRYCWVCFATDEDDATAPWVKPCHCRGTAKWVHQRCIQRWVDEKQKGRAGTHVACPQCNTEYIIVYPNMGPLVVILDTIDGLIFKVCPLIAAGIVIGCVYWTAVTYGAVTVMQVIGHKDGLSMMEQADPLVLLVGLPTIPIMLVLGKMLDWEDQALSLFRRHACKVPLLKRFLKCRCSEDDVARSQEVPPMTDPVSATRVLCGALLLPTIATICGRIFFYSINSNFQRTLLGGVAFITIKGAFKIYHKQQQYIRQRQRRIMDYTDTNIALYRRQRSSEDNQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3L4</accession>
    <name>A0A232F3L4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_015699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001025">
        <property type="protein sequence ID" value="OXU25436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3L4"/>
    <dbReference type="STRING" id="543379.A0A232F3L4"/>
    <dbReference type="OrthoDB" id="10039782at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007624">
        <property type="term" value="P:ultradian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038876">
        <property type="entry name" value="ENOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056611">
        <property type="entry name" value="ENOX1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16001:SF4">
        <property type="entry name" value="ECTO-NOX DISULFIDE-THIOL EXCHANGER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23267">
        <property type="entry name" value="ENOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="296"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="776" mass="88143" checksum="0C623F3E018F5619" modified="2017-10-25" version="1">MLAQPKMAYNFPGMPAAAMPAMGMGPMGPLTPIPGTQNFMELATQGFPPLPPPIQIPGMNDSPLEFSTNKNQPSIIQDSPEDNDRRNDKNESRRDRDSRDNRDSGRRSRRERDRRDRDRDRRDERNDRDRRDDRRSDDRENVISATPSNNHNSSSNNQVTSTSTSTANSNPGLGPPIEPSPGVWGMGIGYPMMGMGPMGTVGPLMGELPLGPHMGHAHGYGPMSMSMISHENAMMGAPILGPEQMMSEATSQIISGALPPANQGTKEIIHCKSCTLFPPNPNAPPPTTRERPPGCRTIFVGGLPENITEAIIQEIFERCGEITTLRLSKKNFCHIRFVLEGSVDAAIYLSGYRVRIGSNGDASNTGRLHVDFAQARDDQYEWECRQRQLQREQRHRERVEKERQRPPSSPPPVVHYTDHEASNICEKIKQDDTFMKAVQIVVTWLERGDCTKRNANTFYSMIQSTNSHVRRLLTEKVSYEEELQKAKELLKGRMQGLLIQFSQIERVFTAASHKKVWDHFTKAQRKNIEMWKKQSSEIKAVQLEETLMEGEGEMEVSDSEDEPQRKKPRNLSACNEDSEKLQSLKEENDSLRCQLEAYKNEVDLLKSETKVEMDAKEKQMKMLQQTLKGMQEQLMQSRKQQAQDDQKIKDLTVKLNATKKEEPTEDEIITLDKDDDVNDDQPPVKPIVTSSGTVQITQKDAKLIGLIATFLHIHPFGASLDYVYYYLQKMEPGLRLNEVETLMQRFPQVFKQELSGIGANMERRWQFSGFNLYRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4E1</accession>
    <name>A0A232F4E1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkylglycerol monooxygenase</fullName>
            <ecNumber evidence="11">1.14.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_011010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:36255"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="ChEBI" id="CHEBI:73418"/>
            <dbReference type="ChEBI" id="CHEBI:83957"/>
            <dbReference type="EC" id="1.14.16.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the sterol desaturase family. TMEM195 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.5" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01001019">
        <property type="protein sequence ID" value="OXU25472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4E1"/>
    <dbReference type="STRING" id="543379.A0A232F4E1"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056853">
        <property type="entry name" value="AGMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF1">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24858">
        <property type="entry name" value="AGMP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Alkylglycerol monooxygenase C-terminal" evidence="15">
        <location>
            <begin position="166"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU25472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="278" mass="32468" checksum="26DF5F5CA2075303" modified="2017-10-25" version="1">MFYLPLAFFIPPSHFVAHHQFNLIYQLWIHTTVIKDLGPLEWIFNTPKHHRVHHGCNLYCLDTNYGGVLIVWDRIFGTFAQERPKEEIVYGLVVSPQTYNPIYLQVFYALAMIGRSLDMGNLRDRLAVYWKGPSWQPGLPRLGLDEFKVNVTSRVKYNPQLPTWQSCYIVLHFCLVLYTHCQLYDEKTFSQELHGISSTAMVINNVCALTTLGLLFDRSKFAGLLELMRCLCYLYFFRYNLITSSTSRSFFALPFVTHFYVASCCLWIYEILRIAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5B1</accession>
    <name>A0A232F5B1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SOSS complex subunit A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_002831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000975">
        <property type="protein sequence ID" value="OXU25653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5B1"/>
    <dbReference type="STRING" id="543379.A0A232F5B1"/>
    <dbReference type="OrthoDB" id="2021145at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056518">
        <property type="entry name" value="HEAT_Ints3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24566">
        <property type="entry name" value="HEAT_Ints3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="8">
        <location>
            <begin position="60"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Ints3-like C-terminal" evidence="9">
        <location>
            <begin position="600"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU25653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="748" mass="87058" checksum="1A5E86E7653C72BF" modified="2017-10-25" version="1">MMEQAKVQFTSRLLLTSCIENKDELEEKFERCYLVLQNLSTGLSEKDIHDNLSNAVCKDKTHEEVCLGFLMAILTEPQDASKHYRDLTLVNRDGLAIILAHLNQMVLEKYLRLNDLARSQLLWLLREMIRTSVTNVDNLCLSLLRHAAGGDISQRNIFLIDALLDIFQENRSWLDKFPFLVASVIYTYLRLIEDHSASHLTNLRQKEITFIVSLIRERITDCLVIGRDLVRLLQNVARIPEFETLWKDLLLNPKSLNPNFTGILQLLQTRTSRRFLQSRLTPDMERKLVFLTSTVRFGNHKRYQEWFQRQYLATPESQTLRCDLIRFIVGVIHPTNELLCSDIIPRWAVIGWLFTTCTLPVAASNAKLALFYDWLFFEPDKDNIMNIEPAILVMHNSMRSHPAVTATLLDFLCRIIPNFYPTLEDKVKSGIFSSLRQILEKRVLPSLYPLFDSPKLDRELRTKIRETFKEFCLPPIADIEVLGTTANLLIYTFSFLKGKIDELHKELCTEIIFDATENSVIEDHLCQTEPLFSDEEEDTQAPIIPITGLTKLEPITENENIYLEIAKVKSNNYRKIATTKKDNSLPFNITLESEELRSVIENLYFEIDNETRCQVMERIVQMVVEDEIDTDAISNLASYLSTILSEQINSDIFPTDHSNDEAFMDSISTPLFVMFRNQFQLCKEEDNRKKLLARVIAEMQIVQPKIGYLLLYFLKVWGKEEEKREVELWFVLIIKFIEMFFFLQLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8J8</accession>
    <name>A0A232F8J8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_014516</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000654">
        <property type="protein sequence ID" value="OXU27164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8J8"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001810">
        <property type="entry name" value="Cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000667">
        <property type="entry name" value="Dynein axonemal heavy chain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000219">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000002">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000001">
        <property type="entry name" value="Dynein, axonemal, heavy chain 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF8">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1923"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2528"/>
            <end position="2673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3110"/>
            <end position="3161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3347"/>
            <end position="3395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU27164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="3538" mass="403288" checksum="08B45005A91F7A8C" modified="2017-10-25" version="1">MSDSESSGENNGMTMVVKDDVKPLPLIRNTGDSDKLVEFQKLLRSMIDSRGASLDPDEEQEQEMNNILKIPTAETTVMEPTGDFRLEYLGSIVQKSLKLKPEKWGRLLLTEDHRNAVLDFLDNPVPAALFVVLTPNAQLIPSCGFPIPCQRTKGVFAIKMKIMVVPRDKEACAAMLLTGDLSHRVVDELATIVDNIFAPLLCKPDNHKELPGVAVQDISRHVHSLRGTLYQVKGQVNGRTVLPMPAGLEKVAEVERMISVEGPQAVDLYLKSAIEGVVIKWAYLVNDVVTHESSTAFDNGQNPTPYVELEYWSTRLANLRNIFDQLREDRVRKMAVILEKTDSAYYPCFRTLFANVVSSLAEAKEISLYLTPLGKCFKSVEEVDFAEAKPVMATLIHSLGLVWANSRYYQSSSKLIIMLRQICNLLIQEARRFLDPTLIFQSDVDEALQRVQISKDVLEEFKRQFDLQKNMPALKKDTLPWTFNPSAVFGRLNAFLKRLSDIEWLFDTVLEFSKLEKIEVGGLMGRSLSTRIVAVYKEFQQLFQAFSTRATDVLEPDDESFVQDCEKFSESIVDLDSKLAAILCQGFDDCGNLESTFKLINIAGSVLERPVIRKQFTNRYSRILELMNNELTVIEILFNRGPRGAMVDLPPLASALQFTNMLKQRIDQPIHAFKSLQHPIIETEEGKSILVRYDKLVEMLKEKQKVLFLEWSKIVPELVKVGLNRSLLKRDQVSMLILNFDPDLFAVLKEVNYLKQMCYDNIPQEALEVAEVSETFRQFRTLLTTTVNFYNEIRRTCRKVEFNLIDMEIARIDSLIQRGQEELRWNSEGLLEYMSELGSLVEDLYKRVKVTQANVEKIRNIIEPWTRMPLIERKDRRKNTLLSLEERGERVAKRDDKSEAWQAYVNYVDKIVVESLRKAVGCSLSYLAENMDATSQNEPLLEARLELREPDLYYVPSLEPDDPDGLDQLVAGLLNDIIGMATLVERLKPDTEGYAEELEKDEDICAMKNEILSGVTRAVEEATDFCGIFEGYAYLWLEDRGIVMQQFLDYSRQLSLDEMDMIVALDPKAPKKCSPKMEQFREQIDLYESLYNEVEDMSTSKIFCVWFRVDLRPFRQSLLNTICKWSSMYKKHLVERVTTSLSDLGAFIRLADEGLLQQIQPGDYAGLVSVMGYLMKVKERQPITDEMFQPLQETIELLKFYDQDIPEEVNVLLQELPDQWANTKKLAVTVKQQVAPLQAGEVSRIRGRISAFDTTIVQYREAFRRYEFFKYDCKNPYTQLDEAHKEIAMLERQMNDIQESASLFEVLVPEFKQLKQCRKELKMLKQLWDYVNIVKSSIEGWKTTPWRKIDVENMDIECKKFAKEIRGLDKEMRPWDTYTSLEATVKNMLTSLRAVAELQNPAIRERHWLQLMKSTKVPSNLSMTRRVLVSSTAVYTLSMLQKLGNMTPEMTVRFVMNDSTTLADLLELNLHDCEEEVKNIVDKAVKEMSMEKYLRELNVTWSGMEFEKELHPRTGAILLRASEELIETLEENQVQLQNLITSKFIAHFLEEVSCWQKKLSIADQVTTLWFEVQRTWMHLESIFMSSEDIRKQLPVDSERFDRIDQQFKEMTHEMAKTPNVVEATNKENLVTTLDILQKELVLCEKALAEYLETKRLAFPRFYFVSSSDLLDILSNGNQPEVVAKHLVKLFDSMARMKFDDSQGNVKPERILGMYAKDGEYVQFANCEMVCEGAVEVWLNRLQMAMRVSIRHYFSDAVVAYEEKPREQWLFDYPAQVSLCGTQIWWTTEVNLAFGRLEEGYDNALKDYLKKQIAQLSTLISLLLGELSKQDRQKVMTICTIDVHSRDVVAKLVQAKVETAQAFQWQSQLRHRWDEKEKDCFANICDAQFRYSHEYLGNTPRLVITPLTDRCYITLTQSLHLVMGGGPAGPAGTGKTETTKDLGRALGIMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVVAVQVKSVQDAIKDKKEIFNFMGEMIALVPTVGIFITMNPGYAGRTELPENLKALFRPCAMVVPDFELICEIMLVAEGFQEARILARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPGRPEEEVLMRALRDFNIPKVISDDLPVFMGLIADLFPALDVPRKRDVEFEKTVKAAATDLSLQPEDGFILKVVQLEELLEVRHSVFIVGSAGSGKTQVWKTLFRTYHNIKRKPIFNDLNPKAVTNDELFGIINPATREWKDGLFSVIMREQANLGGENPKWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIALTPSMRLIFEISNLRTATPATVSRAGILYINPQDLGWNPYVTSWIETRSSQSEKSNLVILFDKYIPSCLETLRTRFKKITPIVDMAHVEMLCHLLSCLLTPELVSNDFSKDHYELYFVFAAVWAFGSAMFQDQAVDYRVEFSKWWINEFKQVKFPAQGTVFDYYIDPETKNFLPWTERLPKFELDPDVPLQAVLVYTAESIRIRYFLDLLMAEKHPVMLVGPAGCGKTVLVAEKLLQLSENYAVTNVPFNFYTTSEMLQKILEKPLEKKAGRNYGPPGNKTLVYFVDDMNMPEVDTYGTVQPHTLIRQHLDYSHWYDRTKLALKEIHNCQYVSCMNPTSGSFTINPRLQRHFAVFAVSFPNSESLTTIYASILSQHLANVEHRFPLSVTDLCGNIVQATLQLHHRCAQVFLPTATKFHYIFNLRDLSNCFQGLLFSGNECLQVPTDFVRLWLHETQRVYGDKLTDEKDIESFSKLQIDILKKNIEEIDEGAIFEKPNIYCHFAGGVGEPKYMPVKDWASLHRLLTEALVSYNDLVAAMNLVLFEDAMMHVCKINRILESPRGSALLVGVGGSGKQSLSRLAAFISSLEVFQIQLRKGYGVADLKLELASLYSKSGLKNLGIMFLMTDAQVPNEQFLVLINDMLASGEIPDLFPEDEVENIIAGVRNEVKGAGILDTRENCWKFFIDRVRRQLRVVLCFSPVGSTLRVRSRKFPAIINCTAINWFHEWPQEALMSVSKRFLQELNELPETYLESVAKFMAHAHTTVNLASRQYLASERRYNYTTPKSFLEQISLYTKLLQNKSKQLKARVERLENGLAKLKSTAVQVDELKKKLAVQEVELQQKNEAADALIAIVGIETEKVQKEKALADEEELKVGVIAEEVLKKQKDCEADLLKAEPALLAAQEALNTLNKANLTELKSFGSPPGAVTNVTAAVMVLLAPNGKVPKDRSWKAAKIVMAKVDAFLDALINYDKENIHPEVIKSIQPYLKDSEFEPEFVRSKSAAAAGLCAWVINIIKFYEVFCDVEPKRKALAQANAELAAAQDKLSVIKRKVTSLEEQLAKLTADFEQATSEKLKCQQEADATNATIALANRLVGGLASENVRWADSVANLMQQASTLPGDVLLVTAFISYVGCFTKQFRLDLLNKQWLPFLRSIEPAVPITDGLDPLSLLTDDTQIAKWNNEGLPNDRMSTENATILTNSDRWPLMIDPQVSNISTIIKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8W5</accession>
    <name>A0A232F8W5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transformation/transcription domain-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_010076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000701">
        <property type="protein sequence ID" value="OXU26908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8W5"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2620"/>
            <end position="3188"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3435"/>
            <end position="3755"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3759"/>
            <end position="3791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3202"/>
            <end position="3221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU26908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3807" mass="434155" checksum="F96051DE16B6EEE1" modified="2017-10-25" version="1">MAPPDPMTQMNTYRSYVTMLADPNAKDESKLKAAQEMSENFEVIMCSTQYPAFLDHLMKNFLKILQEGKPHFISEYNIQQVRKLILEMIHRLPTNDHLRPYVKQILSLMLKLLETENEENILVCLRIIIELHKQYRPTFNPEIQHFLQFVKSIYSELPKNLPKIFEPRPPIRVKDLSEINLDTLLKETFTITPIQSEKKAADGSVLSYNLIPKAVLSLKVLQELPIIVVLMYQIYKQNVHQDVSDFIPLIMTTITLQPSPQHRASPAFNKEVFVDFMGAQIKTLSFLAYIIRIYQDVVAQHSTMMVKGMLGLLSLCPMEVAHLRKELLIAARHILATDLRTKFVPHMERLFDEEVLLGHGWTTYESLRPLAYSTLADLVHHVRQLLPLSDLARAVHLFSKNVHDQSLPTSIQTMSCKLLLNLVECIRQRSDAENSNQGRELLMRMLEVFVLKFKTITKLQMPILLNKAKQLPAPTIDTKPATAEDVKPNIAELHEEKECTKTKFGFPSTHNQNCSVVDYRSLVKTLVCGVKTITWGCANCKSGEVAQSKQFQPKETLVFIRLVKWALQALDIYTIGPPALGALAQSGRPAQPQTVRSKEEKEVLEHFSGVFSMMNPQTFQEIFSTTIDYMVERIFKNAALQIVGNSFLANPTTSPIFATVLVEYLLERMDDMGSNVDRSNLYLRLFKLVFGSVSLFPAENEHMLRPHLHQIVNRSMELAMSAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLEGLNRLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSHTLVSQGLRTLELCVDNLQPDFLYEHIQPVRADLMQALWRTLRNPTDQVAHVAFRVLGKFGGGNRKMMIEPQKLEYNDRETNPPAIVAYFQEPSKGIDFPVEKVIETAFTALKSNTTDPFYRKKCWEVINCYLAASLRLDDDRATLYKFFTHPSFKEGKIPHQQGPHYKSLDTVARNVQQTALTGLFVAAAIKELRQSVLGTMFSIVRHYTMVAIAQQAGPFCLTNKSNRLQGQDPLVLIDALAVIMGHEEKELCKPGNLALVLILETATNILGSKERACQLPLMEYLADKMCSLCYERAWYAKLGGCMAIKFLFERMATKWVLNHLFVFLRALIFVMMDLTGEVSNGAIDMAKANLEKMLRVCVNPGVQEPGNSELLEAQNKALYEVTHELVRQVTSPHTIVREQAMASLRLLAEIQNKTVTEVMEPHKEVLADMIPPKKHLLRHQPANAQIGLMDGNTFCTTLSPRLFTIDLKTVEHKVFFEELLTLNEAEDINLNRLPCYKSVPNLIPLRKSALRALAACHYIADKRQNIFEVLYAALEKPNTELQEAAFECMQKFIAGFQIDMESVHAIMRPMLLTLGDHRNLSLNCVKRLSYLTQLFPSTFSITLCEQLLQHLKKLLENLIQAHKGVSKTGENEQKIATIIGIFHQIPAATPKFIDVLCRLVMQTEKSLLVEASSPFRMPLMKFLLRYPTETLNLFLNDNNIKDQQWSRYLEFLIKHKEGKPFRDVLHKSTTRLITMLLAHSQINSNLTHSEKSELQHQAIRIVSVLIKFDEQWLSTQTQLVTALRQIWCNDDYHALHKKVDSVDFCHWKEPKLIVKILLHYFCHHPNDIDLLFQLLRATCGRYVPDFQFLRDFLENTVAQEYTVEWKRSAFFRFVEHFPTSMSPELKAKIVQLIIIPCFAVSFEKGEDIKLVGSTPVPYQDSPDNVVSVFITKIIDPENPLTATDCVRIALLQCSCLMVELASQYIHDAANKRQGNKLRRLMTFAWPCLLGKNCVDPVTRYHGHLLLSHVIAKFAIHKKIVLQVFHSLLKAHAVEARNVVRQALEIITPAMPVRMEDGFKMLTHWTKKIIVEEGHSMQQLFHILQLVVRHYKVYYPVRHHLVQHMVNSIQRLGFSPTATIDHRRLAVELAEVIIKWELHRIKDEAENVETGGTGVMTGNLKRSPSYEPEAKRMATQAGINQVAVAVTAAAASPGLLVTQKMEPGATKPIERAHADAILNFLLRLACQVNDTTTTQGNPGEQLSRRCVALLKMALKPDVWPQSCDLKLGWLDKVFASVETNQPNYGNICTALELVTFLLGVMKREQILASFKPLQRGLGACIANTNAKVIRLVHGLLSRLMTIFPTEPTTSTVASKHEELETLYGTVGKFVIDGLAAYEKNASAQTSSLYGTLMMLKAACTNNQSYIDRIISPFMRVLHRMAKDHLHPTQTENNQVGSELLIMSLDLVKNRVAVMGVDMRKSFIGSILVGLIEKTQDIKVMKAITKMLEEWMKNKSPVAVNQAPSLREKSILLVKMMQYVEKRFPDDLELNGQFLELVNYVYRDETLKSSELTSKLEPAFLSGLRCIQPHIRAKFFEVFDGSMRRRLHERLLYIICSQSWDAMGPHYWIKQCIELLIVTANSTTQVQMSNQDTLLPSITSLINNVDSEEQKSFLMYSMVKEEPQDMMESGDVKDDIMDMDLSNIDPVTAPEEVTTGTQTTLAQLIANQAEFLEQSKKIRTEQLLNAAAQLCHMDTNLSERVWLDTFPRLWNILDEHQQNTLKTEIVPFVCSGTHVIQKDCHPSAIATFVEALAHCNLPVPMRPALMKYLGRSHNLWHRMTLSLEQMAFENGNNEIKAKRESDCYDFEPDNSPHTEVLDSLSDMYSLLCEEDMWSGLWQKHAHYKETLQATALEQQGFFEQAQNAYDLAMTKFKQDYVSTPAPFKAQREALLWEHHWIRCAKELNQWDLLLDYGSKKAEKNPFLILESSWRIPNWSMMKEALAQVEQNCPKEMMWKVNLYRGFLAICHSEDQHLSAVERYVELASGLCMREWRRLPHIVSHIHLPLLQAAQQIMELQEAMQIHQGLLHGRSSSLHDMKAIVKTWRNRLPVIADDLSHWSDIFTWRQHHYTFIASHYESHQESQTPNHSMLGVHASAQAIIHFGKIARKQNLCGVCLDSLSRIYTIPSVPIVDCFQKIRQQVKCYLQMASVSGKNELQEGLEVIESTNLKYFTKEMTAEFYALKGMLLSQIGRSDDANKAFSAAVQLHDTLVKAWALWGDYLESIFTRDARQISIGVSAITCFLHSCRHQNESKSRKYLAKVLWLLTYDDEKSSLMDVVDKYAVGVPPIQWLPWIPQLLMCLVRYEGNVILNLLSQVGRMFPQAVYFSIRTLYLTLKIEQRERFKSTELAKGHDGGDRSASGAQQAQQQQEVKAKATIPMWMCSKIMHIQREIHPTILSSLEGIVDQMVWFRETWYEEVLRQLRQGLAKCYAIAFENRGAVSEATITPHTLNFVKKLVSTFENISSSQNITNTFGSAGNESLARRAQATVQDPDFQKMKSQFISDFDFNTPGARLLHNLISKFKKWIKILEGKTKQLPKSFLIEEKCRFLSNFSLKTAEVELPGEFLLPKHSHYYVKIARFMPRVEVVQRHNTAARRLHIRGHNGRLYPYLVVNDAGLGDARREERVLQLLRFLNHYLAKQKETSRRFLHFTVPRVVAVSPQMRLVEDNPASMSLLDIYKQGCAKLGIEHDAPIARYYDRLATVQARGTQASHQVLRDILKEVQDSMVSRTMLRAWAAKTFPAATDYWTFRKMFTLQLSLACFAEYVLHLTRLNPDMMYVHQDSGLINIAYFKFDVDDTSGELDANRPVPFRLTPNILEFLTTTGVSGPLTASAIATARCLVQPSFKIHTILRAILRDEVIADHSKKQEDSKNTAEGPTDMKAELLITMVTRAVSAIVSRLNSLAHFDGTDSKVSTLVAAANSDDNLCRMDPSWHPWFIKMVSALPILTTNQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9D2</accession>
    <name>A0A232F9D2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000635">
        <property type="protein sequence ID" value="OXU27275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9D2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="41" mass="4790" checksum="C16C6BB76FE8A3FB" modified="2017-10-25" version="1">MYFPFPMPPVTRHERSVLRSKIDTPESFTALRVIVRLKADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9P2</accession>
    <name>A0A232F9P2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_013940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000613">
        <property type="protein sequence ID" value="OXU27395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9P2"/>
    <dbReference type="STRING" id="543379.A0A232F9P2"/>
    <dbReference type="OrthoDB" id="421979at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076497" description="Fringe-like glycosyltransferase domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="57"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="234"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU27395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="473" mass="53505" checksum="B098B3765F6F1FAE" modified="2017-10-25" version="1">MICIKLGCLVFSTLLLFCSTIALDPSDIVLIVLSQEEGYNAAQAKLLESEIVKQAKELEKEPPKIILTHTLDVHGTWTIVPLLAYLNDQKVEAQWYMFCTETTVIRLSKVLSILDKYDVDIYKNLWIGHALYDNEPTIIHHYAEHTKRFKYPNLASGFVMSKHLFQGLANQANEFISSTVDFSIDASYEFATFVLNEGKGARLTHVPEFCVVSNDNCATYPKPFYPCSKVPAKQNAYVAVKTCAKYHVERLAVIRKTWAQYAENIGYFTDTLGICNLADENLPDGYIVPSTDQGHCAKTYAILKHVAPILEEKNLAWLIITDDDTMLSLARLFKFLTCYNPENSSALGERYGYRTTKIHGYDYLTGGSGVILSTPLVQQIIRPGVCECPSATTPDDMFLFGVCLAYLGVKLTHTPLLHQARPIDYSTAYLASQEPISFHKFWLIDPEHIYKEWFQEADVETFAQEKSNRHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA63</accession>
    <name>A0A232FA63_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_003163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000548">
        <property type="protein sequence ID" value="OXU27744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA63"/>
    <dbReference type="STRING" id="543379.A0A232FA63"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="373" mass="41066" checksum="5781239E64793DF7" modified="2017-10-25" version="1">MGKDDAETIALKKELDDLINKCKICDTPVYHFININTSERITLLFARGRQEDQKKCQDTTIEDVCSSVADAPKIKLSTKKMLKGHINKVNSVHFSGDSRHCVTGSLDGKLIIWDTWTGNKVQVIPLRSAWVMSVAFAPSGNFVACGGMDNMCTVYDVNNRDATGSAKITRELLGYEGFLSSCRFLDDGHLITGSGDMKICIWDLEANKKTTDFAGHAGDIASLSLGPDGNTYITGSVDRTCKLWDLREEVAHQTFFGHEADVNSVCYHPSGNAFVTASEDKTARLWDLRADQQIASFKPPNSNPGFTSCGLSFSGRFIFCGTDDNNIHIWDTLKVQHNGVLQGHENRVTSLSVSGNGMAMVSCSWDQNCRVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAG4</accession>
    <name>A0A232FAG4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_012252</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000626">
        <property type="protein sequence ID" value="OXU27317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAG4"/>
    <dbReference type="STRING" id="543379.A0A232FAG4"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="18">
        <location>
            <begin position="2"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU27317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="358" mass="40733" checksum="7B8F1823F0A22EA4" modified="2017-10-25" version="1">MCYNVLSDKYATRQMYGYCPSWALEWEYRKKGILDEIRHYAADIISLQEVETDQFYNFFLPELKMDGYDGIFSPKSRAKTMAENDRKFVDGCAIFFRTAKFTLIKEHLVEFNQLAMANAEGSDHMLNRVMPKDNIGLAALLRTKEAAWDNGLPQDPLQVQQPILVCTAHLHWDPEFCDVKLIQTMMLSNELKSILDQAGQSFRPGHKSDASNVQLLLCGDFNSLPDSGVIEFLTSGRVASDHRDFKDLAYKSSLQKISGCDKTNEFTHSFKLASAYSEDIMPYTNYTFDFKGIIDYIFYSKQSMVPLGLLGPLSADWFREHKVVGCPHPHVPSDHFPLLVELEMTPTAATSNGMISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAT8</accession>
    <name>A0A232FAT8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000601">
        <property type="protein sequence ID" value="OXU27447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAT8"/>
    <dbReference type="STRING" id="543379.A0A232FAT8"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042292">
        <property type="entry name" value="ARL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="213" mass="24021" checksum="DFBD761763B07294" modified="2017-10-25" version="1" fragment="single">LFALWRRRTSVGHNVLLTGLCDAGKTLIYARLMHTKYVQTHTSVKENIGDALEYNSSVKIVDIPGHERLRYKYFDKYKNSAKGLVFIIDSSTIQKDIRDAAEYLYTLLSDPSLSRNIPVLILCNKQDHTLAKGSNVIKTLLEKEMNLLRVTKTSQLEATDASSSNVYLGKTGKDFEFSHLDKKVDFAESSAFIKDAETPADIEQLTSWLTKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCN6</accession>
    <name>A0A232FCN6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_004786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000414">
        <property type="protein sequence ID" value="OXU28574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCN6"/>
    <dbReference type="STRING" id="543379.A0A232FCN6"/>
    <dbReference type="OrthoDB" id="10072039at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="678" mass="74402" checksum="12BC663609EC1816" modified="2017-10-25" version="1">MSWRHCQSRATANDDDYPLIRNAKYSGSKGGYSSSTTSDSRYEGRMRDSPNGNSYSPAGGLGIGMGTDRDSPRSYSTKPLYKKERENRDYKLSSSRDKYSDCARSPKDKRSRESRDSEHRTNHDRSSGEILHPIKLSSNSSRDSSQRKPTHNSCQDKRGDERGVMERTARFGDWSEHMSSSGKKYYYNCKTEVSQWEKPREWIVRTDNRQRQSNDYSSSRSSHDKHSNSRSNSGSSSSNARDGGSGKSSSRQSDKRGGDYWSGPGGNSGSSREEVSSSRDRDRGDKDTGVSVGSSREQRERERDRDRDRDRDRDRDRDRDRDSCRDDGSGQNQSQASAAAAAAAAAAQQAAQVQDRTTQDMDISPGDSTPTSETITTSSVHDPLPQGPVLLANALPRLSSHPTSVSQVPGKLGSPTQHGNSNAPGPPVSLSNLPRLLSQIAGSKEQPDAQKALQTIQTAILLSRQVSYNLKFDRSACDQFFYCSIPPVKQSGGDRSSCSNDVMTPLKVDTSSNVTGEGPPTPTHSETQDCIDARKLNSPGSANSVVQGISSLQNISTLGTLGSLGNGGLQALSRVQPPLTPSLTPSLANHYREDLTQHVRAFPADILEKQAQKLSEEAHTMGSLQCTRVSAELKTARSIVRLTEIQATLQEQRILFLRQQIQTLEELKSQNSFMSDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCV6</accession>
    <name>A0A232FCV6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000404">
        <property type="protein sequence ID" value="OXU28634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCV6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="91" mass="10545" checksum="2E28C96442CA9B8B" modified="2017-10-25" version="1">MFRATMSPLLEGFEYCPSLPHGEDTRANLETREKESKKQQQQWRRASGCKWDEEERSGTPQRDDTRSLANWALEVTLSFARELPPHPLARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDD0</accession>
    <name>A0A232FDD0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_015218</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000394">
        <property type="protein sequence ID" value="OXU28685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDD0"/>
    <dbReference type="STRING" id="543379.A0A232FDD0"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022824">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13715">
        <property type="entry name" value="PBP2_iGluR_AMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000067">
        <property type="entry name" value="glutamate receptor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000087">
        <property type="entry name" value="glutamate receptor 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000001">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="280"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="290"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU28685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="91959" checksum="9D98E070E60FC1CA" modified="2017-10-25" version="1">MSASKQSKIRESERLKLVELREAEFRVGLLRLQQIYQGLKPGNDTFQVETVKRIQNVSEALDFLRSLEEISRDVTLGRRTYHYLLSGLIMDDRWESEVIEFGAINITGFRIVDGSRRHVKSFLEGWSQLQTSQYPGAGRDSISAQAALMYDAVFVLVDGLNKYVRKKTDKKNDRRTGGTSGGAQQVNATLDCKSNHGWVSHWDQGEKIARLLRKVETEGLTGQIKFNDEGRRQNYTLDVVEMTVNSAPVKVAEWRDISGYQVVPTKRDRHPKSEILKNKTYIVTTIVEEPYIMERRFDNGKPAEKMKDRYEGYCRDLADLITKKLNISWDLQIVKDGKYGSENPRVPGGWDGMVGELIRKEADIAIAPMTITSERERVIDFSKPFMSLGISIMIKKPVKQNPGVFSFLNPLSKEIWVCVIFSYIGVSIVLFIVSRFSPYEWRVLTLGTSRDPSLVSRDGTMQHSHGAQGSPHGQHTSMANDFSILNSLWFALGAIMQQGCDISPRSISGRIVGSVWWFFTLILISSYTANLAAFLTVERMVTPINSPEDLAAQTEVHYGTLQHGSTWDFFRRSQIELYKQMWRFMNENKQVFVNSYDEGIQRVRTSKGKYALLIESPKNDYINEREPCDTMKVGRNLDAKGFGIATPLGSPLRDSINLAVLSLKESGELAKLMNKWWYERTECRHGDKQDTSRNELSLSNVAGIFYILIGGLLLALAVALVEFCYKSHTEATRAKIPLSDAMKAKARLTIGGGRDYDNGRTESKFSHCTTANLPSKFKNLTAHDLDFFQYYAPANAIGNAEADQVHSNTHTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDV8</accession>
    <name>A0A232FDV8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="4">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_009799</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts through its C-terminal domain (CTD) with the CTD of eIF1A (EIF1AX) or with the CTD of EIF5 (mutually exclusive) through a common binding site. Interacts with eIF1A (EIF1AX) from the location of the start codon by the 43S complex until the formation of the 80S complex. Interacts with ANXA5 in a calcium and phospholipid-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000356">
        <property type="protein sequence ID" value="OXU28941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FDV8"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="17">
        <location>
            <begin position="762"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="504"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU28941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1353" mass="151152" checksum="7DDC75552CB8FC67" modified="2017-10-25" version="1">MGKAKKGKRADKDDDFDSDAEVATTTVNDEPVKSKKSKDKKKKADDVDDLADDLQELKVEKTKASKKDKKNKKRGGDDSDNDLPISKDKADSGSDSEAEISRGKQKNRKNQPVKKGFAALSIESDNESENEKPKSKSKAKKGKKDLDLESEDEGEERKPKSKNKKKGKKQAESDDESDHQVQKAKGKGKKGKKAADSDASQDEELKVQAKNKSNAKKNKKQESDDESDDQVPKPKGKTKDKKSNKAVSESDDEFNIVPTKAIKPVAAKKVPKASFALLNMDDDDDDDDNDDQKDVVSPPPSDEESEKTESKDRGKSSKPQKLEPQESQKESKKGKKAKKKRNDSDEDIDKVLAELEMEYSGKKSVQEQVTNAQKIEQDDKKKNKSKEADQEPEKEKADAPAEGEEGSTVKTAAQKKKEKKEREKQKKLAQKKAESTKKAGDTGIPQEVEKATGKPAQVEKDASDGEGEEQDEGTKKKKKGGKEETKAEKTKGPGKKMIAAMQEALKKAKEEEERLKREEEEKIRLEEERERARLEKLQKEQEKKEKKKLKEKQRKEKLKAEGKFLTTKQKQAQARAQAMLEALKAQGLEMPEAGEKKPRPGTRIRPKQVKQQSSTEGQDEAKTSDDIKSDQVQVEIVDKQEKVQEKKQDEEDGVKDAWDAESSEEEPEEDKSDGTKEPISQGAVKTQKSAGKESTPEDEDESSENESDSESQGSESESESESENESDVDDKRTDAERKKEQVRQRIQNRRIEAEKKRTVDNLRAAVVCVLGHVDTGKTKILDKLRRTNVQDGEAGGITQQIGATNVPIEAIQESTKHVKGFADKQFKIPGLLIIDTPGHESFSNLRNRGSSLCDISILVVDIMHGLEPQTIESIQLLKSKKCPFVVALNKIDRLYDWQTMNRKDVQDIIKSQAIITQQEFQKRSKDIIVQFAEQGLNAAVFYENPDPRSYVSLVPTSAITGEGMGNLLALIVDACQGPLAKRLMFSEELQATVLEVKALPGLGTTIDCILVNGILREGETMIVAGTEGPIVTQIRSLLMPQPLKELRVKGAYVEHRQVKAAQGVKIAAKELEKAIAGLNLMVAQKPDEVEILKEEIAKELTHALGKIKLAERGVFVQASTLGALEALLDFLKSSKIPYAGIRIGPVVKKDVMKASIMLEHDSQYATILAFDVKIERDAQELADSLGVKIFQADIIYHLFDRFIEYKEQLRQRKRDEHKHIAVFPCKLKILPTCVFKSRDPIIVGVMVEAGIIKEGTPICVPSRDFLDLGIVSSIEFNHKTVETARKGQEVCIKIEPIPGEAPKMFGRHFDEKDMLVSKISRQSIDACKDYFRDDLLKTDWQLIMELKKLFQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE03</accession>
    <name>A0A232FE03_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000361">
        <property type="protein sequence ID" value="OXU28892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE03"/>
    <dbReference type="OrthoDB" id="7612378at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="241" mass="28259" checksum="F36C047549C9B554" modified="2017-10-25" version="1">MELGFKGVKGDFVLKELAYIDPYEEFPVPKVALFKPPYDWSLLPSKSKSENLYLQHYFHGLNWSDGIISYDKIDAVVQKIKELAEGNSIIILVKGKQKIKWLQPYFKEIKNLEDAGCPFLRSDRFRRLIVCKYHPGGWQNNCAVQNVQAIQRWIARLVQISHLVTDTLRPSSHHRQILQLTKIKQYFVLISFFNTDFNYFSMFSGTMDLINLADKTPSFLPTRRIRDLKHNKMKNEITKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEY8</accession>
    <name>A0A232FEY8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_004897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000336">
        <property type="protein sequence ID" value="OXU29113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FEY8"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13240">
        <property type="entry name" value="PH1_Kalirin_Trio_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000023">
        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047054">
        <property type="entry name" value="Kalirin_TRIO_PH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058918">
        <property type="entry name" value="KALRN/TRIO-like_spectrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23323">
        <property type="entry name" value="Spectrin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="1315"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1469"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1589"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1216"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1589"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1792" mass="203369" checksum="94FFCA17469698C6" modified="2017-10-25" version="1" fragment="single">MDNLRPLITKMDIIRAAEVLPLLQERLAIMPGGRDRRGGLLLLFPTTPRRERAKPEDYRRLLQYLMAIPNDDDRGLRFTIVVDMRGATWDSVKPILKVLHDHFHHSVYVAFLIKPENFWQKQRTSLAKQKKYNFEINTVSLEALARNIDPSQLTADLDGSLQYDHAQWIDVRLAVEDFTWQATDLLDRLDDLQEDLSRNDFADDVGGAKHGIDLHNEMKKKIMKVPVEEIGVVGNRLLQRFNINVNGSGEGGSIESGATGGSESDSRDIANIVIQHLDSVNAAQQHLLQLWHIKKKKLDQCFQLRMFEQDCEKMFEWICHNRENFLANYVEIGRSYQLAKNLQEDHKHFAMNSMNMYVNINKILTMAGRFLETQHYAAGHVRAVAGRLDRAWKEFAAGLDERTAVLGLSVVFHHKAEQYVDSVAGWSQACDATNLPGEIAVLETLIRQHQTLYEAMCQAYTEVYNAYQALLSGLGKMLQVCHSASATIGSDEYKSQTLFHSHPRAVPDCLTKCGISVARLVQVHSTSKKLLYQLDHLVQVCNQPQGIDHATRKHLLSLAIQSQDGHMDGRGGMSGNPAADYSEGASHVLAVIHQILGHHRALEARWHARKIKLHQRLALRLFQEDVKQVLDWLTNHGEVFIRKNTGVGRNLQKARVYQKSHEHFENVAQNTYTNASKLLTAAEELAHTGECAPDEIYAVAQELEAHVSSFAARVEQRRRRLDLAVVFYTHEKELSGWVDELRQELQQDEVAENLETAERLLEQCAQHRTSCLEACASTIVQGEALLQELRDSTEMPDTTGSIAAVEAALDRLAGLRQELEDLWATRKLRLELCLRLRVFERDALEASGQLEMWAQEMQNPPREGSPEQLLRAHNDGVVHMQNTAFQVLQQGQELAQVLDQSGVCIMADGQHTAANRVQVLLEFLNEREMDAEEMAENRRVILEQTAQLVQLQQDAGHVANWIRNGEAMLLTTLRIPENLQDAEQLRHEHEQFQVAIEKTHTSAVQVKHRADALVSANHYDPKSIRDVAEDVTKRWQQLVTCAEERHKLVTASINFYKTAEQVRSVLDSLEREYKRDEDWCVGGEKASQVPNYITKHQEQKEAFLKACTLVRRTAETFLKYTNRSLQFYSYQTTGVASENKVKSSNMPFTTLGILEELLSKENKVLEYWTQRKKRLDQCHQFVLFERSAKQALEWISETGELYLATHASAGRNRAENEQLLHEHNEFKGAAKETRERVKLLIQLADNLVEKGHAHAAAIKQSVAEVDQRYKDFSMRLDCYKTTIEDDLEIQSDEGPKEITIDRNSDPLLEEKIKGKDLKELNEEKRRSARRKEFIMAELLQTERTYVKDLETCIRCFLEETRANKSNAAKFDMYVTYCKNKPESNQLLVTHGGTWFEDLQRKHRVEHPIAAYLIKPVQRITKYQLLLKDLQACCQEGQGEIKDGLEVMLNVPKKANDALHLSLLEGCDVRIDTLGDVVLQDPFTVWDPKQLIRKGRERHIFLFELYLLFSKEVKDSAGKVKYIYKSRLMTSELGVTEHIEGDECKFAVWTGRAPTSDTRVVLRSNSLESKQLWVKRLREVIQETYFSLSMPKSPAKKSSSQRSSRDLEECASLDDSVENLDRNSLASFGSTNTTDSDKTGVAEMTWVVADHSAAPGTRELSVTKGQQVEVLENGSGSGLSSNGGSGNGEWTLVRLASTPGQSEPPAEGLPTRGHYREGFIESSRALTIQISCPSAIKIVTLLGDKYRESSPGGRKEKEISYTQSSVLRCGIPALGKRVCEMQGNNVARDRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG14</accession>
    <name>A0A232FG14_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000282">
        <property type="protein sequence ID" value="OXU29503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG14"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012195528" evidence="1">
        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="138" mass="15478" checksum="2A9B23D3F48633C8" modified="2017-10-25" version="1">MMRILLLGFFCSVFALSHQKENPEPSDAHWQEDLQSCLDQTGLDLSIFGVSRIDEVTGQNLKKLTKVPANKRGCLVACVFQKQGMISKEGVLQNNPPHPDPATKFETTFEDAIAVCRAEENFCKLGNCLFGIYFKHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG22</accession>
    <name>A0A232FG22_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_017039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000264">
        <property type="protein sequence ID" value="OXU29635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG22"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="58" mass="6465" checksum="CE54BEAF2DD197F6" modified="2017-10-25" version="1" fragment="single">QANRTGLRAPTICLYIGIHLRVVFESRRTRALFSPDKGSASTPTNTRSIPIIVRVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG64</accession>
    <name>A0A232FG64_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000245">
        <property type="protein sequence ID" value="OXU29744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG64"/>
    <dbReference type="STRING" id="543379.A0A232FG64"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30562" checksum="ECB4557BA54615C4" modified="2017-10-25" version="1" fragment="single">YISLSYATLVCGNCLNFIIIPIVSATWTPPLYAWYPCNMSISICYWSCYLHQSTGFLTIGAVHVACETLVTGFILQICAQLEVLNHRVLSINLKIQNLALREKDKNKIFLYESFLTNACITDHNSILKFAELLSETFLQVLFIQFCASLSVIGTSIYLLTTIKVYSADFVITTLYLICLLNQMLLYCWYSNQVLLNSRELFRSIYNTDWITLHSKTQKTLLLMMLMASSPIQLFKGAIIKVNLDAFLNVLKFSYSAFNILKNPSKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG66</accession>
    <name>A0A232FG66_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000289">
        <property type="protein sequence ID" value="OXU29448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG66"/>
    <dbReference type="STRING" id="543379.A0A232FG66"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF1">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU29448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16392" checksum="D9A1A63C107AC248" modified="2017-10-25" version="1" fragment="single">MNATTYEGYADLLVGVKHAGMLLYIVNPYETSFERLEDVPDYHLQVWFPFFLLIALENAILYAKKGSSFRLNDHVSSLSHWILQETGRVAFRGAEYYAYIHIYDKFRMWNLSWDSAWTWYVTAVAVDFCYYWVHRANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGB1</accession>
    <name>A0A232FGB1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apoptosis regulatory protein Siva</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000287">
        <property type="protein sequence ID" value="OXU29469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGB1"/>
    <dbReference type="STRING" id="543379.A0A232FGB1"/>
    <dbReference type="OrthoDB" id="60860at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005175">
        <property type="term" value="F:CD27 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097191">
        <property type="term" value="P:extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022773">
        <property type="entry name" value="Siva"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14365">
        <property type="entry name" value="APOPTOSIS REGULATORY PROTEIN SIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14365:SF1">
        <property type="entry name" value="APOPTOSIS REGULATORY PROTEIN SIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05458">
        <property type="entry name" value="Siva"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14561" checksum="5BC84742A04CCD3E" modified="2017-10-25" version="1">MPKRRCPFDEDLSPQMKTHIGELEVLKQDENSMNNVYKKTLQALKEGSKLYPFGKGNSNVTVKMPLEVCGCCRYIDSRKPCRCSYCDQIMCNLCLVPCSKCCESFCQNCSLTVYDTDEQNMCMSCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGR1</accession>
    <name>A0A232FGR1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000250">
        <property type="protein sequence ID" value="OXU29710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGR1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6717" checksum="4ACC2E5C70F5B9BC" modified="2017-10-25" version="1">MRAAAWVVRSSGTIKSKIPVRLLLRLHYVSFSFLLRFSLDRGVTSICGSFFSIDSQPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH92</accession>
    <name>A0A232FH92_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000224">
        <property type="protein sequence ID" value="OXU29890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH92"/>
    <dbReference type="OrthoDB" id="8025217at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="141" mass="14892" checksum="77B76ACC551C0FDB" modified="2017-10-25" version="1">MSFKILNQVGEIDGCSSGGKTTASIATVSPTPPTVPTETSTDPEKCQREAGDELLTDVSLLSIVVAGKPTLNRTYPGYKITCSRCYSILGGLLNLLNIRIGIGGYHCNKVLLEVNINLSGLLGRCQVYGRRLKAGESAGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHJ3</accession>
    <name>A0A232FHJ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in several stages of intracellular trafficking.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000183">
        <property type="protein sequence ID" value="OXU30214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHJ3"/>
    <dbReference type="STRING" id="543379.A0A232FHJ3"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090389">
        <property type="term" value="P:phagosome-lysosome fusion involved in apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07621">
        <property type="entry name" value="BAR_SNX5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06892">
        <property type="entry name" value="PX_SNX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000008">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000001">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014637">
        <property type="entry name" value="SNX5/SNX6/SNX32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF1">
        <property type="entry name" value="SORTING NEXIN 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036924">
        <property type="entry name" value="Snx5_Snx6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="415" mass="48149" checksum="DE0E6F3B2632E4E8" modified="2017-10-25" version="1">MLQDGICDTTDIINSVPTKKTISNESSLEHNDKALQVDISDALSEKDKVKFTVHTKTTLPDFQKSEFFVVRQHEEFVWLHDRFEENEEYAGYIIPPCPPRPDFDASREKLQKLGEGEGSMTREEFMKMKQELEAEYLATFKKTVAMHEMFLTRLAHHPVFRNDHNLRVFLEYDQDLCVRGKNKMEMFGGLMKSFSKTKDEYYLSATVKDVNDFFDQEMTFLTQYHHNLKEATSRADRQTTKHKDVADSYIKISTNLLQLATTDTGKLEKLLTKIAETFEKLRKVEGRVASDEDLKLSDTLRYYMRDTAAAKRLLIRRLKALHTYETANRALERARAKNKDVHAAQEVAEAEQAQTEACSKFEQMSEKGKEELLDFKTRRVAAFKKNLIDLTEFEIKHAKAHAEMLKKCLSVLQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI18</accession>
    <name>A0A232FI18_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000182">
        <property type="protein sequence ID" value="OXU30233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI18"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="9354" checksum="21B9E46F0D369782" modified="2017-10-25" version="1">MQLTDLSNRRVLHVQYSKYTTVYCPSARTRPEIAERYNRYMCVFYIRFNLYNVTFCLKTEKYIYIYICISWIQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI85</accession>
    <name>A0A232FI85_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000156">
        <property type="protein sequence ID" value="OXU30461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI85"/>
    <dbReference type="STRING" id="543379.A0A232FI85"/>
    <dbReference type="OrthoDB" id="6620644at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="161" mass="18110" checksum="7786A12B14033DFF" modified="2017-10-25" version="1">MRSGGMLRVMAFSSPLFASTLLLLLLAHANALPLQYLPEIPGYIPVYIRHGDQPLEEINPALAEAFHESSGILKNIRDDLNDRNDVSLDSNEENSSRENANPPMPPKQLIYNFPQEKSNFPPKDKPTEKESVVMKLAKTSPLDKTDTKKLAQEIKEKKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIB5</accession>
    <name>A0A232FIB5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_012972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000171">
        <property type="protein sequence ID" value="OXU30333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FIB5"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF134">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="908"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1089"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1130"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1184"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1289"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1325"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1529"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1706"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1529"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1718"/>
            <end position="1727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU30333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1727" mass="196469" checksum="B38392122022FD17" modified="2017-10-25" version="1">MCSSCRRDDDDARINDGCCAGGKARRQQGCCLDRPHDCTGTRPRGPSGRGKCRCELEESWNKCTPPRPHRDWPGNFGELRRRWSEHVKRQSCPCDDCRKKSILPLTYNDTVETSPNTDYEDESDDRQRRHTSNDYKCPASSRFSSSRHSSASGKNTSGRCDADNGCCLCQAARRDCCCPSPVQVDARSHENCSCECLEPVECPCSPAERRFPRPGRRCAVADSCPVNRARDECRKCRSRTSSDSEDRCKVNSRQEKHEQPKIQKCRKNTPYDTKHQNSNRSSCCSAKATSHCPNLPGNYIVHIPCIKIYGTFDYLKLLYYYFKVFGLATMTFVTDSTKTTPNRFGTFSRSKYTIVYNVIIILVFVMPCLYNMTIFCVGTIRVKFEDFADCIQINMALFVTVFILSKFCISSDSLISIANSISRITESLLTLSSISLQKRIKVSLEIKQAFIVNISMWIAFIVINLSEIEPWMKNAVNMYVSNFLVSVLILQYSVILKFLQYDFKILNENLIEFRNEESMKIRSPMEMKAKVDGLLKLQKLHESLSDTSRRVSMFYSYLMLVCVLNIFIMLIFVCYYLAKPIILTHESNSSSIMLLRCFWYGLLFVVLLVTLTKFVTATIDESRRTKEIISSCLMISDADEKLLNKLNQFSLYLLHRDVKFTVWGLFTLDESLLTSMAVFGLASMTIDATAAKDARNHFWTFARSKSTVIYNVIFILVFVISHVYSMTFFCRGTYVVNFETIGDCGQTTLSLSVALFILTKSCISRNTLIIIANSISRITDSLLSLSSTSIQENNKISSEIKKMFIINISTWTVLFGTFAFDFKPMTKYSIVIFFSNCIINHLVIQYSVILKLIKHNYKILNENLIEFGDQESMNIRSPSEAKTKVDRLLKLQKLHESLSDTSREVSNYYSYPMLVCVLHVFIILIFVCYYCVKPMILHSKNLSTFAFLRTIEYGFAYGLLLLTLTKCVAATIDENRRTKEIIGSCLMISSDEKVLNKLNQFSTYLLHRDIKFTVLGLFSLDESLLTSMVGSITTYMMFFGKLTNKKIHSFKLLFYYFRALGLATMTCDLGPAKNATKYYCSFASSKSAIVYNVILVLIFVTSNGYSVTYFCSSNYQVDFDTIADCGQTTIYSFIALFILVRSCISRNGLINIANSISQITESLQSLSSIEIREKNKVGLDIKKVLVVNITIWTGLFLSTVLEVMPWTKYTISVYVSNFIIIVLMIQYSVILKFLQYDFKILNENLVEFRNEDLTKVRLQTETKTKVDRLLKLEKVHESLSDASRDVSMFYSYPMLASFLEVFIYLIFICYYLTKPMILGNTYTTFMLIRSFWSGFTYAILLVTLTKSVTATIDESRRTKEIISSCLIIPVDEKVLSKLNQFSNYLLHRDIKFTVFGLFSLDQSLLTSMAGSIATYMVSQDAILTYHQFSTQHLVAVRLYQRLHCYLGCAAIITPLASAASVSSRFGGGEEGPAAAGAMDTVVTDVEDEDSSCISGKSSDWDCRPIVYERGELLIIEDTKDLVAARVDDNEAASAEDESTGSLREQPSPLHDPLPSPLRNFDSHAENYANRPLNHASKRRSDETIFFDVDVLVTEESSLSLRFCGEEGKNEPEKIAPAYGELEEKISGAKRTNQLFEELNNSGSKCRGNEESHRKSLNKQISRMDRPDRISTIDLHCSKFTIGYPDNKKTKKPERCPATCRYFVGSQKAASDDHQRVLSNRKKTRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIM9</accession>
    <name>A0A232FIM9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dCMP deaminase</fullName>
            <ecNumber evidence="6">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000142">
        <property type="protein sequence ID" value="OXU30614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIM9"/>
    <dbReference type="STRING" id="543379.A0A232FIM9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="8">
        <location>
            <begin position="174"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="304" mass="35078" checksum="9754E9C19B575422" modified="2017-10-25" version="1">MRSYFFKHINSCREPKRIGDGFIIDLNSIFMEMAYLVSKHSNDPKCKVGACIVSEDNEIVSIGYNHMPRFFDDKTRSEHWKSKGSKLKYVCHAELNAIVNKNHKSMKNGKIYQTLAPCDECFKIIVKSGIKEINYNYDLPKWYVKEYMKKIITINQAAIGKICEMTLKTSEQDKWNQYFMQVAYLFSYRCHNTKNRNGACIVNSDNQIVGVGYSDCTEDEDLKVVVKYCAELNAYKNSQLGCIENGKIYVTSYPCHDCAKIIVQCGIRKLFYLGRKGSDEDTQQMFNEANVFINPISEETEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJP5</accession>
    <name>A0A232FJP5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000131">
        <property type="protein sequence ID" value="OXU30688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJP5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="57" mass="6756" checksum="85C2626F425481A8" modified="2017-10-25" version="1" fragment="single">IGRVYICRAKTKSKEIFPSLTHNIPELRRGQLRNVCQAYVPTIYRGKARLLERTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK59</accession>
    <name>A0A232FK59_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000093">
        <property type="protein sequence ID" value="OXU31055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK59"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="158" mass="17446" checksum="19F7F7CCC83CD935" modified="2017-10-25" version="1">MAYKILSCNLPGVCQVTLMPKIKFWVLNIKFVSIANKIPFEVQTQHITLKGDPIQTVTGDNSLGTALIEKMVETKVVGYQEESLMVTLYLTLNLIIAGMERAESFAFRVAKVISKSSSQFNKIRLRNSSGNALIEKIVDSSCTISRVPIFSTPDSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKJ0</accession>
    <name>A0A232FKJ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000079">
        <property type="protein sequence ID" value="OXU31185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKJ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="56" mass="6672" checksum="38EEB257C5BB515B" modified="2017-10-25" version="1">MLPSSKFVFLKFDIQIDILKVSRYNREVMFFNVQLKKKNCTASMLKNKIFKDNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKK2</accession>
    <name>A0A232FKK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">LIM domain kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSAR_001653</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Alberta</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000078">
        <property type="protein sequence ID" value="OXU31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKK2"/>
    <dbReference type="STRING" id="543379.A0A232FKK2"/>
    <dbReference type="OrthoDB" id="20134at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09365">
        <property type="entry name" value="LIM2_LIMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06754">
        <property type="entry name" value="PDZ_LIMK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000082">
        <property type="entry name" value="LIM domain kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000038">
        <property type="entry name" value="LIM domain kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000038">
        <property type="entry name" value="LIM domain kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000197">
        <property type="entry name" value="LIM domain kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF4">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 16" id="KW-0440">LIM domain</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="20">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="20">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="21">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="387"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="288"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="682"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="844"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="916"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="758"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="786"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="919"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1030"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXU31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127769" checksum="250411340D19155F" modified="2017-10-25" version="1">MDEPAAANTSDPGGGGSSGDNEDKDMSACAGCLNGIDEDEFIQALGQEWHVDCFRCSACDAALSSWYFEKDGLLFCKDDYWTAYGEACQGCGHVITGPVMLAGDHKFHPECFACNSCGTFIGDGESYALVERSKLYCGVCYKRQMQPLNKTANYPFVRKPHSIRLVEIPPSTNGQEKQRGIRLTLDSTPSPRSCGGALFRISELLRNVRGKICKLVASMTEVLFRLCCHFSNYRLNMSSDLMSLHIGDRILEVNGTPVKDQPIESIENLIKYSDTVLQLTIEHDPDAVSRRPTFSTAHSSIISRTSSPKTSPESKDRLFKRRDEGYNSGTRSRQLRRTKDPKQKERSSSMSRLLDGASPTNPACDLSRTRSFRVEPKNQRIFRASDLVKGELLGKGFFGQVYKVTHRDTNEVMVLKELYRVDEEAQKNFLKEVAVLRSLHHNNVLRFIGVLYKDKKLHLVTEFISGGTLRALLHDNSETLPWEQRTSFAKDIAAGMAYLHSMNIIHRDLNSHNCLVREDKTVVVADFGLARIIQNGNAPDKQSPGKYTRRSDGEVRTSRKERKKRYTVVGNPYWMAPEMMKGNKYDEKVDIFSFGIVMCEIIGRVQADPDYLPRSSDFGLNKKAFKDKFCANCPECFYTIAFLCCDLNPDKRPPFEVMEVWLEGLAMHLSVDAPLPSDLEADIKNYAGPSPSSSESTTPDVLSPQLKTITEGQVHREKRRASGCDDSTLESDFYKESSECKENVEVPPKNTKQAESSPVEKEKRYSRQNSKSKDSGADTTSHKSSRTYSRQSSKSSTCSEDASTTDRKRGANSVRGNLQVALDKYALEKYPSVEKIKYVGQADSPCIVPTSPSNLNGNESKRSSYRVNRSRTNSKKSPDDSPITDGTSTNPKADNGKFNIVGVYLRQFGKSILLDKENTSTGSQGSKNSYSVNNDTEPKNKTSNSSSTTPLRRTKISPTKESPCKSAFTNDTTETNKTITEDSPKRKQKSKAKELQQPTVSRKNSNKRRNRRRGKSDLGYVESFSFDDSNDSKNEPQEKDNNKEDIKEDANSRYIENELLLEASSDSFSDLYDDYFKSKAVERQDSFGSDSAVGTMKSDFFADIDLAKIRDGSSALLQKLCRTSDKCPATPNRASSPFESTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL96</accession>
    <name>A0A232FL96_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000071">
        <property type="protein sequence ID" value="OXU31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL96"/>
    <dbReference type="OrthoDB" id="9970237at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029245">
        <property type="entry name" value="DUF4528"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34651">
        <property type="entry name" value="SIMILAR TO ENSANGP00000021391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34651:SF1">
        <property type="entry name" value="SIMILAR TO ENSANGP00000021391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15031">
        <property type="entry name" value="DUF4528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="168" mass="18983" checksum="8AD39B0BDD85D1D9" modified="2017-10-25" version="1">MDSPLGSFRTTTAAANAMTGLRAALVTGRSSLTSRGYATKPLSSEVLTSYLEQTGEPPWTSYFVRYRDVRNDQFAMSHFNWPVGQSNYQVLRTGCFPYIKYHCSRRPHRDLKIEDGFFRLIKMLNLGLPTLMYGLAATILIRHSEVVKTPSGDVTIFFLLPEDKGSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLA2</accession>
    <name>A0A232FLA2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000051">
        <property type="protein sequence ID" value="OXU31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLA2"/>
    <dbReference type="STRING" id="543379.A0A232FLA2"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="725"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="383"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="860" mass="94927" checksum="60CFAB32097087E4" modified="2017-10-25" version="1">MNCTKERCDELGRFKCKNKNYCLANYFFCNGRYDCGDKSDEMYCSEKRCIESGKFGCKNTKKCTPKRWVCDGSPECPDLSDEADCSVGRCKEVGKFKCRNGTRCIDEDRVCNGSTDCNDGSDEADCTEKRCNQLGKFKCKNKNYCSSRKFVCDGYDDCGDSSDEVDCSTEHCEKVSKFKCKSTDKCVTSFFICNGQDDCGDNSDEVGCEGQLPEMTTSPFVRTTSRREYGSSIVPEDSATKYPYAKPSTSEVLLNALNFTVAPKDYYENTVVPEDSAKKYPDEEHSTFNVSSNLSNQSSTLCLLLLFGVVLSAIFIAYGQMPEFAKNAYCVFGTPHVIIVKLGPSRLNGTKEAAKSQEMEPAGMPRPKGQRTQWKQWAACISATLSMVAAGTVYGWSTTIQTRLTDNTTLDVPIHVTGEQSSWIISLVVIGSMMGAFYGAYVAASCGRKICLLMSSLFYILGWLLVIFAHNVWYLYISRLILGIGVGMSYTANPMYVSEVADVNIRGALSTLIAVNVFTGSLISCSVGPWTTYLTLGIALLCIPILFVLTFAWFPESPYYLLSKGKSAEAASAIAFFQGITDPDELRQEVELVRRNIGKDSSDEFEELKFSFSDFLLLMKTRNRRALVIVMGLILGQQLSGSFTTMQYLEMMFHDAKIGIDSHTATIIVLVVAMVSGGVSTMTVEGAGRRLLLLYSSFACALSLGVLGVYLLIKSTGADLSSINLLPVFDIIVFQAVYQIGLGTMPNLLIGELFPTNVKGIAGAVIIVFDGLMGFIVSKYYEPIFIRLGGQVVYLFFCVSTLGIFFFIYAYVPETKRKTFLEIQDILDELRPFKAHSSTSISCLPLKRSGGEEDNKTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLM8</accession>
    <name>A0A232FLM8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase CHFR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_014845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CHFR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000040">
        <property type="protein sequence ID" value="OXU31651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLM8"/>
    <dbReference type="STRING" id="543379.A0A232FLM8"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="466"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="192"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU31651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="564" mass="66429" checksum="D89352398AA53858" modified="2017-10-25" version="1">MTAMEKSDSGTMEICEPMAVSVEKCESMTEEDTRGSRKTETEETDTDTRKRIMEKELQPVLTRLPSEEPSCGSNCIRINKDQFRIGRKPDNDEVILSVWISRNHCVLHRDKNSDNWFVTNLSSTDTLLNGAHIPRNSTSIIQAGDVLQLSLSDCFKYTFSYVKKDRECIKYPKLEENKCELGNVLDKQRSFVAFQESERKDLEKQLLDKQLEQEKLKEELEKLLQDQKFTKTCNNDLNNQIAELQKKIEVGNSTELELQQKYRDLLGKLEEERLKFEEKLAQEKQKWQQVLKETKQEKEKLEMSMVEQMEELREKLEKKQQEEWQKKIDNLLLEEKNVQLKLQNEKQLLEHKLKQMEEELKQKEEQAKLEQQLQLQQQEEQRLQLAQQQEQIQQQQAMITQPIDIQHCIIVEIPSSNKFNLNNQLPIMETIDLTSDAESTSSSFKNCQDEAVIDKVNNIMDEQLTCSICSELFVRAMTLNCTHTFCRHCIDLWIERKPPNERQNCPTCRTKIVSMTRSLVVDNFIEKMLESLTPEEMQKRKNLIQERRIYTARHPKKGVCTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMF4</accession>
    <name>A0A232FMF4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000023">
        <property type="protein sequence ID" value="OXU31852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMF4"/>
    <dbReference type="STRING" id="543379.A0A232FMF4"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000049">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Kazal-like" evidence="4">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10315" checksum="31561C71DC6EB85F" modified="2017-10-25" version="1">MVIADRYVQKKRTVLRAEPCEITFCGWGMSCVISESGKAMCQCPSGCPESYSPVCGDDGITYDNDCQLRRASCQKRKDTRVKHQGACGKSQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMX9</accession>
    <name>A0A232FMX9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMX9"/>
    <dbReference type="STRING" id="543379.A0A232FMX9"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF237">
        <property type="entry name" value="MIND-MELD, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="12766" checksum="EE8F5DD207342320" modified="2017-10-25" version="1" fragment="single">EIEHCYYHGTVKDYPGASAAFHTCNGVSGVIHLGNETFKHPHVIFEARTKASKGCANSGSLEWGSKSRRQKHVMGLTDIITNRYKRDVREVAKYIETAIFIDKAMHSPGKNSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNE2</accession>
    <name>A0A232FNE2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000011">
        <property type="protein sequence ID" value="OXU32039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNE2"/>
    <dbReference type="STRING" id="543379.A0A232FNE2"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU32039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="552" mass="62881" checksum="5B48511278156379" modified="2017-10-25" version="1">MYARKLNPELEKLREEVLGPPSLETVVRNVEEAASKIHSSFLFENEGKELLQKLCLFLSATASGKSYGDWQKFAAVLGLMTEQIKCIDYDFKGLQDPTYYVLLAFSQLAEATMDKIIIALQKIDRPDVINRVTDCFNYFIQDIVQNRSLNLKDGIYKSSTSPRAPLVLCPVIQKHHEINQSLAKVPYKPNITCQSASLKYGSIAMLTFANDGRRTAEEIARIFRSKNPKIGVIILQEQEKHVYSKAEEFIEDCFKQVNYIVPILTVGYLNKINNYVEGENDNTDLDSKYLSKYVAHNNEIMIDLPKGIDLTGYTLILPSVAVGNVGQLTVDLLISSLELRRVGRIFDTSFIPLVGPDPYNETSQDIGTSVDFYIYEEKKVIVLQIRSPLVLRPSNFFIEVLNFVTDYKIGKVIILTSSFGHEKNDEQIRTVPFRYLATENVKAEYGKQFEDMSWIALEPKMLDDFSGQTVLKIHGGGYAKTLFELLGRNNIQCIIVLKFCSEGDNMPDAIELINYFNKWIRLVPVDERNACKLKFPPSWKFLFGNIPPRELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED89</accession>
    <name>A0A232ED89_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007487">
        <property type="protein sequence ID" value="OXU16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED89"/>
    <dbReference type="STRING" id="543379.A0A232ED89"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="624" mass="70348" checksum="31A4DBD7287C3FFB" modified="2017-10-25" version="1">MELKPAPESLYAGLVDDSEITTTTTTTSSSSSTATATAAASEDSAATAALDFEKESKEELRARLMEEKLVLPEKEKTETPTSTSPKKEEFLAPLPELSKWEREEGADTAGLDDGSQVADKEIAESEGNEKTKVVTTEVLKRAENAIFQKAINAIRPIEIKKISESRKVLYQNPEPKILDPEGERESRKSVNVTLNVNKNERNVEISSEPMKKSKFERSKLKSSSQQQQSLSPTRLSAKERLGEKIEEEAKLAAGKVAADQRRGDSSTGSGNSNSKTTGDKTPKSRSPKPSSKSDRRVSVTTELDTPIIPNPERKVFLEDRKRDRSRPGNETKRKRLIVTVSEASGREPMKIRDRSELRKPERITRTPPLSTYKARAKEEEEEKDERKRDKKTRDDKKRKKEHRSRSKSRDRKKRKDKKHKKDRDRGLDKRQPKHGKDKDATTGKDNSGDEKKETTSTETTAVTVSGENRKKQRRNPRLVSDRKRSILDEASFEPDYSASDSESEEDDRSTLLATKRAKVDDAVINVDAEAKSKKRPKLSSSEDDDSSSTESSSSESDSSVESHRKKKKKHKKRKKRKVRKDSSSDSDVYSDSSDSSSEEEKPRKKKKSKSKSKQSKKKKKSKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDM1</accession>
    <name>A0A232EDM1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006233">
        <property type="protein sequence ID" value="OXU16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDM1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="216" mass="24811" checksum="1D0969E3272FEB28" modified="2017-10-25" version="1">MLEEMRALVPVYRQSMDVRREKCLKRTRSFDIASDCFSEPFVRLGLVHVLIKTVNRCVKKINAASTCTNIDRQNQFFFAMARKILEENAAIITLPLMQLSAKEFISVIRVVSDGCVSRAREPPRQDRTPTDSCMICACLNCEKFARKNVTHLAWRRKNAKLDEDVADALAFDNRLCSEPHGDPVFFNFISPEDMKTILTPADKDQLTNRKYVFLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEK5</accession>
    <name>A0A232EEK5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_006668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005291">
        <property type="protein sequence ID" value="OXU16781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEK5"/>
    <dbReference type="STRING" id="543379.A0A232EEK5"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU16781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44594" checksum="4BD796F8533FC136" modified="2017-10-25" version="1" fragment="single">MQKLYIRPVESQSALVSHEKIIRRTSSSAAAVEMWVSKKSGLSLLLAGLCLFSELFSAASAGIATTTTTTTTTTTTTTTTKKKQVCVIGAGATGLATIKQFADSSDEFDIVAFDRNSEVGGLWIYSDSVDLDEHNLPVHSSMYKNLRTNLPKELMAFPDYRDFRGDDRSCVTHETVLAYLKNYTDHFNLRQYIKLNTMVDRVTPILGEADWTTTKYSVESRDLNTNETAETSCDAIAVCNGHYFDPRIPKIPGIETFPGKVMHSHHYRKPEDFADQTVVILGASSSGVDISIEIAEHAKTVYLSHNKDRIKSPLSSNIVQVAGVVSANGSSLSLKDGSLIAADAFVYCTGYVFSYPFLDERSGIKVQDNHVLPLYKHLINVHQPSMAFVGLPLLVVHFPLFYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF91</accession>
    <name>A0A232EF91_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005113">
        <property type="protein sequence ID" value="OXU16982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF91"/>
    <dbReference type="STRING" id="543379.A0A232EF91"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="20523" checksum="09CAEEB38C93E27F" modified="2017-10-25" version="1" fragment="single">MCDNSINIASCGLSEISASEQRQITNLIDALLPRDGRNNKVLKTTDLIEHEIKLLHSARPVKQRYHPVSEKMQKAICGLSEISASEQRQINNLIDQLLPRDGRNNKVLKTTDLVEHEIELLHSARPVKQRYHPVSEKMQKAMCEQLDNLIEAEIVEKSHSAWNNTIVMVKKRDNSYRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH62</accession>
    <name>A0A232EH62_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004577">
        <property type="protein sequence ID" value="OXU17700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH62"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7460" checksum="C1E7D105E2EB16E1" modified="2017-10-25" version="1">MQTIAPATMLEWWKIIHIYITFPIFDDFNNLGLSYSLMSKTVLLVRPAKLLSKGSEYARDIYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHF8</accession>
    <name>A0A232EHF8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004512">
        <property type="protein sequence ID" value="OXU17800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHF8"/>
    <dbReference type="STRING" id="543379.A0A232EHF8"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10281" checksum="F2F2E754A2A7090D" modified="2017-10-25" version="1">MTSERMLSSLYMYIFPGFCRLRMHTKGGSPVAFVEYQDVRYAAQAMATLQGSLLVSSDRGAIRIEYAKSKMAEVGFTNLWMEGSKGEENGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI78</accession>
    <name>A0A232EI78_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 11">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 11">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004213</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 11"/>
    <dbReference type="EMBL" id="NNAY01004350">
        <property type="protein sequence ID" value="OXU18021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI78"/>
    <dbReference type="STRING" id="543379.A0A232EI78"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000107">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="12">
        <location>
            <begin position="384"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU18021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="482" mass="55113" checksum="B33EB5E8878DFDF8" modified="2017-10-25" version="1">MRGVSFLRLRRCPGKLLQMKELCRFYSAEPKNKLRNVLKLSDRGMYQEIFPDTCVNHVSTLVNHNPQCVYAGFDPTADSLHIGNLLVLMNLLHWQRGGHQVIAVVGGATGLIGDPSHRTNERVALDQDVLNSNITSIKKNIVTLFENHEKYFWKDMQYPLPPIKIVNNLSWYENVNILDFIRDIGKHFRMGTMLGRTSVQSRLKSETGMSFTEFTYQIFQAYDWLQLLNKYNCRFQIGGSDQMGNIMAGHELISRTARLNVFGFTLPLITAEGGKKFGKSLGNAIWLSPKRSSSFQMYQYFIRTTDADVENYLKLFTFLPLNQIKQIMVEHRQSPENRKAQQILAENVTLLVHGDEALQAAKNATLLLYDKSIESLSIMSQEQIAAAFEGANIVDIVPDDSNMTAFDLAMKAKCFKSESDAIRLIKAGAFYINYKRVTDLDEKIKFGNHILPNYITLIRTGKRTYHLVRWLELQRVENESSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIK3</accession>
    <name>A0A232EIK3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004219">
        <property type="protein sequence ID" value="OXU18183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIK3"/>
    <dbReference type="STRING" id="543379.A0A232EIK3"/>
    <dbReference type="OrthoDB" id="7701518at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="170" mass="19272" checksum="5252941B4F8D52CD" modified="2017-10-25" version="1">MASDTKSLAFNTPKDSTTAQPSNQGTYAKAAAKKIYHSKEQAIALDSIKGITIDDYIDGLEKVIDPNQITFISKISGRRVCIYLSNAEHVEKLSNQVIMIKETALRIRIKPVSQISHIRASLSKPGRSHILSFRRQVYIHQEEEKLIPESTQIVFEDTPHWIYFSTDLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIV4</accession>
    <name>A0A232EIV4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004147">
        <property type="protein sequence ID" value="OXU18299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIV4"/>
    <dbReference type="STRING" id="543379.A0A232EIV4"/>
    <dbReference type="OrthoDB" id="7700412at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="133"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="248" mass="28174" checksum="B57652FC2737CC8E" modified="2017-10-25" version="1">MQRLSLAVSITLFREVLQSASDLLVIISSYETIIMRVLLNLVLLLICHRASSFPSLFNVSKINEDNFEKLGILKSNNYFQDAQIFNSYNITVYTPSENTTTPNKNNQTIQTVQAAQTIKIPEFYKLTPGIGAHRLLTSKKTWNQARNQCITDGAHLVVITSAEEEEVIKKLLASQMIDEIWLGIHDLFKKDDWVTIFDQILENVGYAKWNKGEPNNFGDDEHCGSYYKDGLNDVPCSKEMSFVCKIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJV0</accession>
    <name>A0A232EJV0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003950">
        <property type="protein sequence ID" value="OXU18602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJV0"/>
    <dbReference type="STRING" id="543379.A0A232EJV0"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000169">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="534" mass="60943" checksum="268E9B2435F58D82" modified="2017-10-25" version="1">MVLPCDWQTTTQKIAQRGQYLLETGQWSDCKFIVGQEPHQQILEGHKVFLAMSSPVFEAMFYGTMAEKNDPIPIRDVQPEAFKALMEYIYTDRVDLGSFELACELCYCAKKYMLPFLVEECTKFLWSDLSLKKACRAYEFAKLFEEPVLMEKCLQIICSKTDEVLKETSWDEVEQGTVLTLLDQEELQIFSETDLFNALERWARAECGRKSLDPADPKALKSVIGNALTKIRFLTLTPQEFAEGPGKSPLLTQEEAFSILMNISSPKSKVPMPEGFSMNTLPRAKVKVLETSELKKINPMTVNIPSTFSMPMRPTYSMECSSAIGNPSFFIRDLSYPDIVREEDRISRDSQEVPNEILITNIRDRPKFYCMRSSMQQSNFCNFCNDVMDCSLTFTVDRNIFVLGVQVPSQILTAVDHLPSTFGGMDQLHADTTYTEVLYAHLLDSDGTRLTYTHYTTKASLKELVEISFNRPVYIQKNKIYKVGVVFNKPGWYPIGNCSQRVNCENVSFTFNVGVNGVDYLRDGLIRSIVFTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJV3</accession>
    <name>A0A232EJV3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_002839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003929">
        <property type="protein sequence ID" value="OXU18639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJV3"/>
    <dbReference type="STRING" id="543379.A0A232EJV3"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU18639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="404" mass="45961" checksum="BCD99B2FE2DDB4D5" modified="2017-10-25" version="1">MTKMMRTTSRFYNCWRSLERRNAGFAYGCSNLKIGSRLFLQSVNSRFTSDVSISETDVSKFVKNLLDAHGRGRKTEFDDTLQQFTVKTLIDERTKIYENIENLAELVEEDKDMKKLAEEEKLSNEARLREIDNELFSALAQSLSGDNFDEIILEITAGVGGQEAMLFVKNLLEMYIKHLSYLGYSYDIIEMDESPQGGCRHASIMISGKGSFEKLRHEAGVHRVQRVPATEKSGRIHTSVVSVGVLPQPNDIQVEIHAKDLRIDTMRASGAGGQHVNTTNSAVRVTHLPTGMSVECQTDRSQIRNRELAMAKLRAKMYEQKLARQLRSASEMRKQQMGMGERHEKIRTYNFNQDRVTDHRLSNGTLHNLKGFLEGGMALDGLHERLSKDMQHKLLMEVLDSVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKH7</accession>
    <name>A0A232EKH7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NF-kappa-B inhibitor-interacting Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003790">
        <property type="protein sequence ID" value="OXU18866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKH7"/>
    <dbReference type="STRING" id="543379.A0A232EKH7"/>
    <dbReference type="OrthoDB" id="10002389at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22620" checksum="F38BE6F1495F201D" modified="2017-10-25" version="1">MGKTTRVVVCGMKSVGKTALLEQLVYGNVTPKTEIHPTIEDIYVANIETDKGAKEKVRFYDTAGLEPLQSSLNNQQLARHYLGFADGYVLVYDTAKPESLDVLLPLKKDIEKNKDKKEIITIVIGNRTKPDTEQRILENTASKAANWCAREKLKHFEVNVMDRPSLYEAFVYLSSRLNPPQNKSTFPQLSMGRKTGKVEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL77</accession>
    <name>A0A232EL77_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003608">
        <property type="protein sequence ID" value="OXU19116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL77"/>
    <dbReference type="OrthoDB" id="6740702at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11106" checksum="1D4212C05ABBD30F" modified="2017-10-25" version="1">MRSLPENGSINPIVWLELFIRDIYSYIISLYDENDIIGVFYRSLNFARGPGGLSLRLVKNFFYNNLWNLINRLAQIINIPNGGRGGSRKRINIDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL98</accession>
    <name>A0A232EL98_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003617">
        <property type="protein sequence ID" value="OXU19101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL98"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8336" checksum="3D43F0C647B19EF6" modified="2017-10-25" version="1">MSILPTLGTRNLAERCRHDIRVLRPQKPPSSKTGLISINIDGVLIYCLFRCTLYRLWSHSTRILTHYKLKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELC9</accession>
    <name>A0A232ELC9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003608">
        <property type="protein sequence ID" value="OXU19112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELC9"/>
    <dbReference type="STRING" id="543379.A0A232ELC9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="554" mass="63485" checksum="B6A6CDC83ADB341D" modified="2017-10-25" version="1">MKTPAYCNLPITEVGGDEYLHLGVRNALFKCLSSTPINMHPDTLLQLDFSTDVASLNKVGKILMWPIQIRIVNILNSSPYIVGVFKGSRKPTSTLKFFQPFKEMQELHDNRLDFQNKNVVVRSRCFVADAHLLVLFLWVIADIILVLLVQDAGHFLLLHNAIRILVDPGHTIQSIDFAENCIKLLNETSSDVYGVEFLSYNVHALLHLPDDVRSFGPKPSQNLQQIANRNAEKCHMQSKVLVDPSRLKFIAKHVKDPTPPVDDYNYCEYTNSWDIAATTGSTAVEEAKYCNCIDQHHFAAKKSMLKMLKDMKKRNSPKARTRPACFPFKSIADRLEFNNSNEGRYDAVVNYLTYQGGVNLCDEVNFYFKNCFEFDADLIRNLSWLCSRIDDVKVSLMSTRFAHVCEAAMNLNKDALEKPTKDKFATAMTKAIKNAKEARVLNEPQDELNNRLQSNKDYGDPLPPRQLEPANNDEEDEDQYADEIEDQEEESDEEEGGENNEDEFEEKSQERLKKEEKHQNEDEENYWNGFIKNQEDECNNDDDDPLNCDLFAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELW7</accession>
    <name>A0A232ELW7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003494">
        <property type="protein sequence ID" value="OXU19331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELW7"/>
    <dbReference type="STRING" id="543379.A0A232ELW7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1197" mass="136998" checksum="83C3A62DCA025DDD" modified="2017-10-25" version="1">MLWTKQEVDCYARELFCGMKNETKKILMCYQLAELYYGAGDFESARQYLSRYVEFHKEAKAHKFMGEILEALGQKKAAIAQYECAFKLNSRVKELIPKVCKLLSDPEVASDISISRFWVENAYRWFPRKLVSQLQEKISAIERLTPYNEENPIKAELVSRPMDVQVNINLLKHYVDQNKLDEAYKYAIDIETTHVYRNSLVWYRELVEILLKCKSKCREIETFWIEYISSLERYAALSIKETFSSIIKIPGAVKAVYNFDQCLFEAKLSLPSFPECILKHMWGQLNFHLACLLLMNTHRDPFSRGEAAFLCTPLFFTAMLVEPIDLEAFGDRERLQTWYHEGSYRCSQAGHVLYNYARGNKEELVNNLKSLCTGSWKKLVYQKIFSWKFYHEKMQSSYFVNNNAIDTSSLRFLSHNELQKYDQVAEEVWSNSLHHQVWPAIKLRTDNSCSSICEGPQPNLTSHLFPDIPFSVENLSQTSPDSLSRLDVDAFLNSTAFCSTAVIQKQQTNILEYSDQPQALPADLTAPLCSTEQEKWWHAACKIHRKELLDDDSKLFFQQGLEAVRCIGNDNLHPYILVHLARIFHYRAKQLKNENSESNDIPALESRSEVYWSAAVPLLQKLQNNQTISSSYVKLFDYAGSHMDSIELTHAIEEGKIGLARKLVRSGQDYEAIKSLEALKCPEASFEQGKIYLKLNDETSGSLQETKIEHITLLHKARMYFYLTRDRLCSPDTDPKHPLKSELDTHIATVENQLKKFDTDTSFYAVRNSDYCDDLSSNKSYSSAHEDEHLIDTDSLPELIDVSLDCDKTPISLERLNTKIDQIARSIESLKDQNRAVLCKLDEFLKVSAHCKGNMELNAATSYPQPPGINGYCANYRDPPLATLFIYPPTIDTETSPSYSANNSGSDYAPAMVNPLAVTRQNSPGSYHYPAPSVHHDPASANLDYQQSLGGRCPIYGAHENIASQQQPAKSEPELCSTTTSAGSCPNVIMPISETLPTTYSSIRPTFSFPTFIPTTAPIKTSKTANTFDRRCEDKVFCRRATFYRFNDNAGKWIERGAGEMKLLRYREHGTYRLLLQSERLHKHEIVCDFPLTADQEFREIGIPDTRLTWTGINRADNDSHEIETFAVKFETPGDVLVLKRALEQAQKNIVENHINLIKRLILYPELEVGWVFLILLLGLNEVARTALKNFLIRFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMF2</accession>
    <name>A0A232EMF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Luciferin 4-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003385">
        <property type="protein sequence ID" value="OXU19498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMF2"/>
    <dbReference type="STRING" id="543379.A0A232EMF2"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="44"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="452"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60457" checksum="F8E887CA0237C6C7" modified="2017-10-25" version="1">MSFNVPKRIKIEDFVIEDNIIKGVDEHFDETLSIGEHLLATLSSKPQHVAQIEVETGKQTTFAEMKDRSVRCGIWLKKQGVGSNDIVVICSKNNLDVYAPFFATFYAGGVFAGWNPFTVASKPIQHLMKLFKPKIIFAGEDLVDALQKAAKLENVDAKFVVFGKHSSLPSFHDIIKLPTDEEVRTFRPEKINPQDNGLIVQTSGSTGFPKGVVHPYKNLLPAVGSFIPYCAVGDVVMWYSTCDWVTGIVFTLRSVLLRNTRIMHTQFEVEETCRIIEKYKVNRVLLSHIAMGHMLKTKALNRYDLHSLKLICSCGSKVSIETLQGFRDALPNTLVLQAYGLSESGRAVMSQSENSKSVDSIGFVTSCNRVKIVDINSGKALGANEPGEICIKSPIMMSGYLNNPEATKEVLDDEGWLHTGDKGFYDETGEFFIVERIKEMMKYQNFQISPTEIEEVLASHPGVMEVAVVPLPHPEDIDRPMAFVKIVPGFQVTEGELVNLSASVLGEIKKLRGGVKFLENLPKTASGKINRPVLKETAKAMAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMP3</accession>
    <name>A0A232EMP3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003344">
        <property type="protein sequence ID" value="OXU19582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMP3"/>
    <dbReference type="STRING" id="543379.A0A232EMP3"/>
    <dbReference type="OrthoDB" id="5920040at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33450" checksum="596A9FCEAE087C26" modified="2017-10-25" version="1">MWAIAPCLNCLRKAHHNNLCPSRNRCRHCNQKHHTVLHQDVAQPSPSPQGEPMLIDMARVLLRSKTGHSGSFRALINPASEGSFIAAPDYATLGPVNCILGAYLYPALIQEGLRQGPPIMPIAQKTKLGWIIIGPTTACTTNATTSLRLFWKIEEVPTQLVLTEEKVECERLFQDTHYRDQQGRYVVRLPFKSEPTLPDYRVVAVSHLLSLELAQEYRKFLCEYEEMGHMERNPESMVGSEGMEHDKWSANDPTLLEGIESTTSTSVRSFDVDEVVSTLGLQWSPSFTRSNAPSPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENG5</accession>
    <name>A0A232ENG5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01003173">
        <property type="protein sequence ID" value="OXU19871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENG5"/>
    <dbReference type="STRING" id="543379.A0A232ENG5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU19871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="182" mass="20799" checksum="60830E7A1D48222A" modified="2017-10-25" version="1">MYPQVLCLSPTYESAKQTVEVATRMSKFCREIKIKFAIAGVEMAKKSNKIEEHLIIGIPGKVMDCRILQFKFVDTKKISVMVVDEADIMTEKSASWLAEKMTVDWHSVTVLSNDLTMDREVCILNRFRVGLAMVLITTSVLAQVINVNQVKVVINFDLPMDEVGEAHCETYLHRNRKDRTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENI9</accession>
    <name>A0A232ENI9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003158">
        <property type="protein sequence ID" value="OXU19897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENI9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="13346" checksum="35883C418CE8BE26" modified="2017-10-25" version="1" fragment="single">EHARSTLYDIFACECNIVITGDCSRPPINKVPLEMKSFLSDPRTTRLMNISTMNANRKILAFRGQDKQKIINNKSNTILQKERLQLTLKKNSAILTELAPVIRHCTKTRQNYRSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENJ8</accession>
    <name>A0A232ENJ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-methylacyl-CoA racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003150">
        <property type="protein sequence ID" value="OXU19902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENJ8"/>
    <dbReference type="STRING" id="543379.A0A232ENJ8"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008111">
        <property type="term" value="F:alpha-methylacyl-CoA racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008206">
        <property type="term" value="P:bile acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42208" checksum="BC4EF91ADCD17960" modified="2017-10-25" version="1">MSLKGIKVLELAGLAPAPFCGMLLADFGASVIRIDRPGSNSQIQDSLGNGKRSIALNLKSKKGVDVFKRLSNRCDVLIDPYRKGVMEKLKLGPADLMKSNTKLIYARLTGFGQDGPYAEMAGHDINYVGLSGLLSLFGRHNEKPTPPSNFAADFAGGGLMCAFGIAMALLERNESKKGQVIDASMTEGTAYLGSWFYRSRNLPGLWTEPRGKNLLDTGAHFYDTYETKDGHYMAVGALESQFYHIFLDKLGLTEDELPHFDNFEENREKLSNIFKSKTQDEWCSIFDGTDACVTPVLTLDNVASHKHNDYSKTFSIGRDNLVIPNVAPKLSRTPGVSCATRFSNINPGEHTIEILNEYKFTSKEIKDLVDNNIVEQTTKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENN5</accession>
    <name>A0A232ENN5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003118">
        <property type="protein sequence ID" value="OXU19948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENN5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8414" checksum="53D2AFE80A279C57" modified="2017-10-25" version="1">MSDDQRTEELLGPTSCKICTKVIANRNPRKCDKCEWHYHARCTPTQPIFDNGKRKFKSAVIACWFIISSLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENW1</accession>
    <name>A0A232ENW1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_002644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003055">
        <property type="protein sequence ID" value="OXU20044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENW1"/>
    <dbReference type="STRING" id="543379.A0A232ENW1"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22479" checksum="A3FB551B0263AADB" modified="2017-10-25" version="1" fragment="single">SQLKLYKMLRAGAGTIRFISTNSAAPLRTKKGRLLESVIRVDHAGEFGADRIYAGQMAVLGNTSVGPTIQHMWDQEKVHRQKFEELIKKHGVRPTALLPIWNVAGFLLGASTALMGQKAAMACTVAVEDVIVEHYNDQLRSLMDISDENDKEILDTIKKFRDEEQEHHDVGLDHGAEQAPFYEALTNVIKIGCKTAIAISKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPI5</accession>
    <name>A0A232EPI5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002936">
        <property type="protein sequence ID" value="OXU20264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPI5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="54" mass="6263" checksum="E844CFC38091758F" modified="2017-10-25" version="1">MYYNRRITKFQIFIVSVLGFMGGIYIWKPLLEEHAKKQRELALSEANAVSVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPP5</accession>
    <name>A0A232EPP5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002913">
        <property type="protein sequence ID" value="OXU20335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPP5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="231" mass="25343" checksum="F2542B6FDD5C161A" modified="2017-10-25" version="1">MTVLCPHYDPAIGWYVIVVGHDGPKKRMIMSPLHYYKKMGVVPPVGAVFTDADFIGLEDDSFDEESNILDPNSLPIPSSDVYALPSVTKVSPKPSVASIIPEAGFSTDTTDNIFMPEVSDSPQYAPNIPEVGVPKSLLNFANAPSHHAGLTPEFMLANVSETDEPTSMYSQEFSSFFYNHQTTTSSIEPQPSTSNAVHDIYTPSNSSLAKSLMSLSYDNYDEDDDYNMKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQF7</accession>
    <name>A0A232EQF7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004379</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM231 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002773">
        <property type="protein sequence ID" value="OXU20590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQF7"/>
    <dbReference type="STRING" id="543379.A0A232EQF7"/>
    <dbReference type="OrthoDB" id="426438at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019306">
        <property type="entry name" value="TMEM231"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605">
        <property type="entry name" value="CHST5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10149">
        <property type="entry name" value="TM231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU20590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="298" mass="35359" checksum="1B5D476B2BD0AE85" modified="2017-10-25" version="1">MPILDIYSSNIKYLYRVRICSISAFVVLIAVIFALVTPFIFVYHAGGFWIRTRTYWEKPNVHFKHKYFLLIEQENSNPMICSTFTHYKDNAIKDDCHIVKIQEVDNDKNGFQDLLHFEAVFFTSKPIRSLMLLLFFNYELKEHIHVVLEAMTVIEYTVAHEVQELHFIGDLMLRQNNVLLHDEIYYLEDNSTDLNTLSLSDLLVENSNRLLSGKIDNLRVFPKLGFIKDEPVRVKAEVFYVTQSMNYQPGFWEEMKWAWMQYLSILVVVIYFVRRGLTRMFAAKRLRSYIVVPWDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQY9</accession>
    <name>A0A232EQY9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exosome complex component RRP40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_006238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002718">
        <property type="protein sequence ID" value="OXU20696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQY9"/>
    <dbReference type="STRING" id="543379.A0A232EQY9"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000038">
        <property type="entry name" value="exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="11">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="25593" checksum="B93A513E1C400127" modified="2017-10-25" version="1">MEVSVGDIVMPGDRIQGIESTDKNQKVILGPGLRTDGETVYACKAGILKKRISIYYVDSYQKRYIPSQGENVVGVVTQKAGDIFRVDIGANEPAALSYLGFEGASKRNRPDVQVGDIVYAKLIVASKDMESELVCVDSFGKKGKLGVLSPNGMLLTCSLSLVRKILKANCPLLRLLSEELKYEIAVGMNGKIWIKSKSSVEDTIAVANAILAAEFTPPEEYQSLCNSITKSLALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER11</accession>
    <name>A0A232ER11_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_006493</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002670">
        <property type="protein sequence ID" value="OXU20809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER11"/>
    <dbReference type="STRING" id="543379.A0A232ER11"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012150015" description="GOLD domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU20809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="208" mass="23439" checksum="FF97A489B979DB31" modified="2017-10-25" version="1">MKWLTIALVLALSSRQAYSYFITVDAHSEECFFDKVDFGTKMGLTFEIAEGGFLDIDVRIVAPDGKVLYDGEQESSGKFTFAAHTPGIYTYCFSNQKGTMTPKVVMFNMDIGETPKQPGADSPAAGAQEGDAPNAKLDDVIKELSTSLWSVKSEQEYMQVRDRNHRTINESTNFRVVVWSFFEATVLVCMTLGQVYYLKRFFEVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERG8</accession>
    <name>A0A232ERG8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002601">
        <property type="protein sequence ID" value="OXU20958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERG8"/>
    <dbReference type="STRING" id="543379.A0A232ERG8"/>
    <dbReference type="OrthoDB" id="3205605at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="13441" checksum="29C5E4BC364CB13B" modified="2017-10-25" version="1" fragment="single">YPGKNITSDLLENEEYKAVSFGTLPESAESSLSPGAIDLLKRLLQPEPRLRIKSVLALQRIAFYMGHDIRSYTLKKVSPFQLLGKRIESTLTSPVDDFNDFDSFVGAGSTTRTWAQSTRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERN3</accession>
    <name>A0A232ERN3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002572">
        <property type="protein sequence ID" value="OXU21024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERN3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15901" checksum="7B213DE7B2C64587" modified="2017-10-25" version="1" fragment="single">LEVLLDLPPLDRVVRACAFKASSRLVGGENCKTLADKGLATEILPVIAEVGCDRLTERIQFAIPYEERMVRRRTYPNESGKVRYTDGSKTANGVEAGVWEKGSAREIVCSLNQHATVFQAEIRAIMECVGRVIKEGECGSSITIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESM9</accession>
    <name>A0A232ESM9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-related protein Rab-24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002393">
        <property type="protein sequence ID" value="OXU21370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESM9"/>
    <dbReference type="STRING" id="543379.A0A232ESM9"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23362" checksum="9445FD4165133079" modified="2017-10-25" version="1">MTTREYFKVVLLGETGTGKTCMMKRYFNNVYNPMEPATIGAAFESKIFNVYGKEYQMGVWDTTGQERYRAICSLYYRAAVAAIICYDVTLQRSFRQIEYWISELRRVEESCRIYLCATKCDLLGEFEANPPLSFVESFASEKNAKFFKTSSRTGENVDRIFDEILEDYVSNVLITPGSTNTIKLPTSRSIWKKRTKKCCSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETT5</accession>
    <name>A0A232ETT5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002228">
        <property type="protein sequence ID" value="OXU21762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="11561" checksum="CFA09A7CCDD0C1D3" modified="2017-10-25" version="1">MPICAKTVPECNALHTIHRVKMNNENYMEIGVLLVELSQQVIELKQYLARRRKKFRRWWSKPLIRQNYLTGYXSNELRRVFKDTRLCIIYSFISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETT7</accession>
    <name>A0A232ETT7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/arginine repetitive matrix protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002220">
        <property type="protein sequence ID" value="OXU21780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETT7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043407">
        <property type="entry name" value="Nkap_D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940:SF1">
        <property type="entry name" value="NKAP DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940">
        <property type="entry name" value="NKAP DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15692">
        <property type="entry name" value="NKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41245" checksum="0FC01FEAEB550887" modified="2017-10-25" version="1">MSRDDRRRGGSNSSTKLRMDSSSSQSKSHGDSSSKRKELDNVMRKARESQSSYWNKKLLEAEEKDPNRWRHSGYKEMYIGGISTNNSKFHQRSPKHRSPHPRSPRPRSPRSPRIRSPVRPRSRTPRNRNSRSPRRRSPRITNSFILKPRSPIIRRSNTPKTRSPKVRRSHTPKPRSPKTQRNQANNAQSRITKSPSSGSTCSDHSCSVCSPKDQRHIVNRRLSQSRSSSPARQHLPTKEVASLISRVGTSKTSRPRSPPIPRPQTPPPMPQPPSHHPKEYNKLTKDLKARKKESHRNKLADNPRVPESVQMMHKHVKLEKTHNMHPDVSMIHPPAESSGTDDSDSSSVASHAPPPKMTLSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETW2</accession>
    <name>A0A232ETW2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clp1 P-loop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002210">
        <property type="protein sequence ID" value="OXU21793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETW2"/>
    <dbReference type="STRING" id="543379.A0A232ETW2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="3">
        <location>
            <begin position="85"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU21793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="231" mass="26461" checksum="24BE2EC5A26CBBAB" modified="2017-10-25" version="1">MSKNSKQFKLLPKSELRFKLKAESEKVTLEVVGKVYASINRETRMERYLYCHTAMDALKDHAQETETRGPVCMIAGSPGVGKTTLLVTTLADVCLRRLEADRKTKVSGTIINTCGLSLTLTLMHVAQAFKMDAIVVLGEGGIYHQLKKEMPEEVKVIHLPDVNGDAEDRDELQKYKIKSRVVKQYFNGIPRKMLYPYRLTKMKAEDCTKLFEVDPRSNLHYHLRFHRHTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUB8</accession>
    <name>A0A232EUB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002149">
        <property type="protein sequence ID" value="OXU21934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUB8"/>
    <dbReference type="STRING" id="543379.A0A232EUB8"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="504" mass="56561" checksum="2D25F8FE4F2E5AFB" modified="2017-10-25" version="1">MAEWFLTKLNRFGDLNEVQAREEILTEIKIKFANLNANEAAEITRNLDLSRLFSQLTSNDRDFVEQICDALNAVLHASEPGQILWRYTPEIYKLLSHQLPAVKIFALDEIHRVASNPSTLPQLLTKVDLLNLVTDTVADEELSVAKRAMDVLKKIGQSTDGLKLIYSGVLLRSIAKLLATSDIVKFRVYEVVVDIAKNSKECLEASVRSGFLQSLISMLDSDDILLQLNALEILRELALSQEGLDYLEQQEVLQQLSEKIAKAHETPLSNLLIPGLMKFFGYVAQLCPNEIFSRYPVVISSLFEVIESDDQTILATALDTLGYVSSTVKGKYALQELGNAMPSALKKISEIIQKMPTELRLRGLNSLTRILYVEKSEQDNRIVSLTKSWFDALCEEPLKLIVSLCKQPFADIRQASLDVLVAVASQEWGQEYISTHPGLVEFLLDRNVESFKECRESKFAIVKALSESVPNIFDAQTIQKFKKFVSEGPYYVDAITEIAFEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVA3</accession>
    <name>A0A232EVA3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_006024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002022">
        <property type="protein sequence ID" value="OXU22286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVA3"/>
    <dbReference type="STRING" id="543379.A0A232EVA3"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="71"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="392" mass="43467" checksum="12BBFD4C1934C667" modified="2017-10-25" version="1" fragment="single">PSDDNTSPLSSFVEEQCQPIMILSKSSTGLQHATKFLRLFLPKDHRKNCRYAHFAFYPDTKTERTGETKQMNMYQAINNAMHLALEKDDNSVVFGEDVEFGGVFRCSVGLKERFGQSRVFNTPLCEQGIVGFGIGLANVGTTAIAEIQFADYIFPAFDQLVNEAAKYRYRSGGQFDCGKLTVRSPCGAVGHGALYHSQSPEAYFAHTPGLKVVVPRGPVQAKGLLLSCIDEPDPCVFFEPKILYRTAIEDVSLDHYKLPLGKADVVREGDAITLIGWGTQIHVLLEVADLVQNELGASCEVIDLCSILPWDVETVCKSVRKTGRCIVSHEAPLTQGFGSEIAATIQEECFLSLEAPIGRVTGWDTPFPHVHEVFYLPDKWRCFEAVKNTLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWP8</accession>
    <name>A0A232EWP8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001829">
        <property type="protein sequence ID" value="OXU22779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWP8"/>
    <dbReference type="STRING" id="543379.A0A232EWP8"/>
    <dbReference type="OrthoDB" id="9856535at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="439" mass="50223" checksum="E737EE1C8EB4B381" modified="2017-10-25" version="1">MKRANSGSPEPCSADTLPPEAKRSKILYHDEVYVYSLLDLSDDVLLHIFKYLSSFDLMSLHLCCTRLHNLCYDRTLWRTVDLRARHLPLEELNEYMKFIQPVTKTVAIRGNKRKSEFPELDESFLNTLNLKCENLQELILEDYSILRGNIQIKNFPRSLQKLSFKGCQIIKDGLNGENNNKSYLWGIDRHMPNLTCLILTNCHWLNSHSFMAISKISKLKEVRLNSCHGLSEEVAYASLACRYGLKSLEILDLRDTFVGDSVVSSFNQTSTLTEIYLERPSSETVQHRPDERPPQQEVLLVQLQRGPEAIHQNHQVVNGDAFNRLIFNMIDDTVRGNISDRSVCALGLVNHEINQEIIQNRNEVQVVQGRPRTSTNPNLKKLVVRNYAGVTNQTLINFVVNGPKLEYLDVTGTSVTKEGLQFFKTNRPNVTIISSFDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXK4</accession>
    <name>A0A232EXK4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">WW domain-binding protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001703">
        <property type="protein sequence ID" value="OXU23176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXK4"/>
    <dbReference type="STRING" id="543379.A0A232EXK4"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="47451" checksum="9EE10DB34DBFAD94" modified="2017-10-25" version="1" fragment="single">ADYWKSQARKYCDFCKCWIADNKPSVEFHEGGKKHKENVAKRLKEIHRNSAKQAKAQQKFENEIEKMEKAAMAAYLKDVESDNRDMTADTIIHKKTESKQQEPFNPNRVPDAAPEAHPRFNESKHRQTAADVDPLDPYAKQKLARIAARDERAKKQAAKKAEEDQQQPQKDKSDKGKGKKPKDEPSGSGPPVRKVWYEARAQGCPYSYYWNIDTNESVWEPPMEGFMSLAEQAEELKEQALQEQLLQQIDQEEAKDKAELLEEQRANAEREKLKEIRKRFYANKKAESRDPNDEALEKSEDEGEEEEEEEEKTPYLRDYSVPDKPQPYGSWQVVRTVEKTKIDLQLPRAKVPSVPIITYTEPEPPQPSRVFKEKTITHVSTGDSDDEAPTVSFKKRKLGSKNMRRRMTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY09</accession>
    <name>A0A232EY09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001669">
        <property type="protein sequence ID" value="OXU23272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EY09"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="425"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1700"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1315"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1450"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1640"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1736"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1753"/>
            <end position="1763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1773" mass="200181" checksum="B113FC40123EC62B" modified="2017-10-25" version="1">MQGYLYYNEFDLDGLESLYEEPQKESGDSHFLKANFRLKDCNSGINFAYIHDQDMNYYQEPTSYYHGNYGRDSEVRDFNHTSMLGSIPEPSRSEENDLGYDPDYDEEVNKLLEEVEEELLEEDSTVPKAENVTIVKADRDQYEDFYDEFPPEEPIGEIPFWYLKNLDKKQQLAIERLRSLSLLVSYASPKAWEHIKRIEHDHHTPFCKINPPRHPPVNKPWQNYWKFKCNTKCKVDPPEPNHAHTADCEEILLEHFPTNVSTKTKNIIRTEFPDHVMRTVELFQNFVNATAKTNPYLDSDVVPDTTYERPSWTEIRVRVNYKNEILLVAYGKAVTPLLEPLKKVFKYGVGRTCNVVSLSCINILWSLRKYKSNGPAPKHLYGTIDLRDKVGPIIINYNAENKITFNSAESEQLGRVMMEYLNPTPETTVIDIGCGIGVLSLMLATKCDKVIGLSHESNDIKLADQLMKLNKIHNASFISCTTKDVFTKCSSLTKKSISVAVLNLTTPFGKSPDVMKSLRNLPTVWRVALYGTFSKEFQKHITILTSSDHHMGDEFLPMQACVVEKSPTMPEDFHIVVVFERKSLIEPSVDLIGFGPTLNLTEDSDSKCVKPVVIPDVKTSEIVGKGYGKFRQYDSPALPKGSKSENVTPVIAPPPSNNDEPTSVLPPDYGKPVKKSPPLDIAKLYEPRPDPVVHRQLKKIYDSPLLPKSKDSTSAESKKSDSSFLTKSIKAESDVPSTTSTDPRCDFLSDLKPLSPAPTDPRRGFSSRCDSSLPLSTDPRCDFLEEAITFNPNREPFDQKKVPIRKKERNNLGSMRPKKENSFDYPSIKKEKESFPNSSSSQDSNSRSPPPMKKEPLIEAPTQTTITRKAFNIPSTFKTETVDSTTFPMKKNTRFDSPTQTTFTEKAFNIPPTFKTETVNSTTFPIKKETRFDSPPLPGYLPPKHSARPPDYVAPSANFYVRQPGFNIPPPSFNVPPPGFMAPAPGFMPPAPGFMPPTPGFVPPAPGFSVPPPLPKQESLRSSVEEEEEKLSPDSTFNKLPKQNSNASSKPDDVFLDAIIKSEPMELDEDCNEEKLPREQPHSSVQNNELEKFKGDPKELTPKQEPTQTFPAVRIKSEPIDPSELSDHTNEPPTSTELPDFNELPVRIKTEPIDEDEPVMTTELPPPTKIKQERLSPTLDREAFMNMPTPVHRPASLVERDRNSVSPPPASANFKTMDGFEFSVQPNQSYLVGMASTTVKKETEVEEGELEDQDETPISTPSQPDPVVTVKREASPEKFEEKPPLIRVKKLGNISNSEDDEISIIGEKKSKKIKKEKEKSKSKYDSKYKKEKKKKYKGLDLDMRKLMNEKRKIKRILKRQRDSYDSSLSPSPDRKRGYRSPSTNWDRGGRSPPAAYRRANRSPSTKFQRWTRQSPSPSGKYSSRASPSRDRWSRRSSVSPSSSRRRRRSSSSSIESQLGRSPSLSRERRLKRSPVSPSERRLKRSPVSPSERRFKRSPVSPSERRFKRSPVSPSSSRYKRSPVSTSSRRFKRSPVSPSSRRFKRSPVSASERRFKRTSVSPSDRQLSTVSPPPNKSYRYSSPSSSAKRFKRTQTPPSERPLRRSPSSPIERRFSRSPISPSGDRNSRRSSLSPGARIFQRSPSQYKWTRTSPLSFGEINSMLQWETRSPSAPRFSQSAMGNYADLCKTSLSPVFDSIKRKSSLPPEALGNSATRKTESGNEIDDQWDIPGKADMSPISTSPANSPKNSLPPDSVSSKPCTTTADPAVKDESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZW6</accession>
    <name>A0A232EZW6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001413">
        <property type="protein sequence ID" value="OXU24056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZW6"/>
    <dbReference type="OrthoDB" id="10036464at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038757">
        <property type="entry name" value="BRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259:SF1">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="339" mass="40011" checksum="0CDD966F0BF59035" modified="2017-10-25" version="1">MSTNHYKKEIDNIVNYAKKNNISEEQVNEIFNECFYLLETKSSSRLQFILKFIKWLTIISFLLITSGFVLYNHPKTHNILLRNVQNLIYPGLRIFRKFAVPVITVYPSLTEWYDEWCLLENPYFEVSDMDCWPCNSVNSVQDLTGYNVTSTFNTGIPFTRIEKTETVDIKELYKTYVKYQDVFRKDAALVSSNKLNYRTMDDVMQSRLDLYPFSNGSTHIEWRIIRMEPGRKLRELFPKLPGIPDWWNPSMEKYIFIDEPKSDSYSLPNPECANVIIQCTSGERLIELNPSPECTRNCQKLKVLLTSHQSLWYNWWYWRPISTPSNTTAITVMYLTSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0V8</accession>
    <name>A0A232F0V8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001339">
        <property type="protein sequence ID" value="OXU24311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0V8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="91" mass="10230" checksum="96DC4B4A3444C64A" modified="2017-10-25" version="1">MSSTRSICCESTSTMSKLRKPKTAYEIIFGWDRFNSTWLFVLLVSFAIWCGVFFAVYVPVVDDNAGHQGHEGHGEHGGMEHGGMEMKSHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F167</accession>
    <name>A0A232F167_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_007768</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001391">
        <property type="protein sequence ID" value="OXU24138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F167"/>
    <dbReference type="STRING" id="543379.A0A232F167"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36354" checksum="6EDB80F4F46EA7A6" modified="2017-10-25" version="1">MRTASLSDARYEPRVVQCNSTHPSIRLHTHFPLHGLSSASDQRSELLDMDILQIFGDYVHLLGMIILLAKLWLTKSCAGISGKTQLLFALVFTARNADLTIRYVSLYNTILKIVCLAITYCTVLSIFLFFRKTYDRKRDAFRIELLILPCAVFALFLNKAFETIEVFWAFSVYLEALAIIPQVYLISKSKEADSVVMSYISCLGLYRGCYVLHWLYAYKNSMDIPLEQIAVASGVVQLIFYFDITVRNLPILKPKQCMNSTEVTAARDKEATVRETVTKDEVTEQVVRLPDIERDATTAIKDVKEEAAACGSASATEESVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1X5</accession>
    <name>A0A232F1X5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_011487</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001296">
        <property type="protein sequence ID" value="OXU24448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1X5"/>
    <dbReference type="STRING" id="543379.A0A232F1X5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU24448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58338" checksum="C4C1F1B3CABBF3F2" modified="2017-10-25" version="1">MALTTSDWSLDAWILISAVVVGLYLYFRRNLDYWRKRGLKYVEPTVFFGNILPCLLVRKTPDVLIREIYEKGAGEQFIGFHVFNKPYLVVRDPELIKNVFIKDFNNFTNKVLCGNHTDVMSSTNLFVASNPPWKSIRTKLSPIFTSGKLKKMYELMEEICSDLQVYLDKLDIDEKVGKPIEIKEICAKFTTDLIGTTAFGMRLNSLTDPNAEFRKNGRKVFRSTFKRYLQLLALFFIPQLRPYTNAKFFDEKATDFLCTTFWNVINERIKSGFKRGDLLDMLIEIKNNQDNGTDNTLRLEGDALVAQAAIFFIGGFETSSTTMSFALYQLARNPESQTKLRNEILNALETTGGKVTYDMITTLPYLHMVTLEALRLYPTIAWLDRIPETDYTFPGTNVTVEKGVPVVLPLRALQLSPQYFPNPNQWDPERFSEENKKNIVPFTYFPFGEGPRGCIGIRLGYIQTKLGILNFITKYELAVSKESADLQLEPLNVTTQAKGGIYLNLRKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F295</accession>
    <name>A0A232F295_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001244">
        <property type="protein sequence ID" value="OXU24623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F295"/>
    <dbReference type="STRING" id="543379.A0A232F295"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="122"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="392"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="716"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU24623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="990" mass="106155" checksum="D51C44073D626509" modified="2017-10-25" version="1">MLFAEANVLGNKLCRKQVSVVKDLLARGISALRGGDSGGPLVHSGDTLMGVLSTSPICCKENIKPAMYTRVSSYLDFIKKAVNNAKDPQILSKQIHESSLSVVPFRLLGDLLLQAALDAEGIVGGEDAELGDFPYQISLEVVGKSICGGSIIDDTHVVTAAHCVISEEGKFFGYPMKVVGGIADLKSKGSSRVAVDVVKVYATREYDPTNVFARAHGDIAVLKLAKPLGIDSNPNLDTIELPNPSKTYAGEKAVISGFGWNYVNLQFNPSIGGVEETGGGGYGKMRFADVDILSQSKCQRLARAISKNHICGMVVQKSAKPEGVCSGDSGGPLVAGEKTLIGVVSTSPLGCRENKEPAVYTRVSEYIDFVKKALKGQTDSSILQAALEGEGIIGGDDALPGDYPYQISLEVSGNSICGGSLIGSNHAITAAHCVTDTTGRLVRRATKVVAGISELRTYPAGRVSVDVEKIYIPKLYDPKTFNQHMAGDIAVLRLKQSVDFEDNPYVGKLKLPTAGKSYAGERVVITGFGWTKINTNKNPWTGGIVETGGSRTGKLKWAESDVITKAECQKGYRSPVLDSHICSKLVQRTSTPEGICSGDSGGPLVYNGDTLIGVVSTSPLGCREDKDAAVYTRVSSYLDFIKKSVNDIYDSNAKTLTLFCLHCRNNENDKYISQRFILTSRTDFTIMNLQTSLVLAFATIALLAGSAVGALDGEGIQGGEVVELGNFTYQVTIQVNGRSICGGGIISSTHIVTAAHCVTDEKGEFTKKPMKIVAGIHDLNTWAPTWFASDVQKVYVPKTFGRTDFKNSIPGDIAVLKLFMPLNMESNENLSILKLPTEKRSYAGEKAIISGYGWNWVDLVENPETGKQEEKGGGNDGKMRFAEADILGTEECQKGYKSKITENHLCASLVQRDSDQPEGICYGDSGGPLVYNGDTLIGVVSTSPLGCRETEAAAVYTRVSSFLDFVYKAVKDVNDESIRTTTLMIVGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2K4</accession>
    <name>A0A232F2K4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001211">
        <property type="protein sequence ID" value="OXU24720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2K4"/>
    <dbReference type="STRING" id="543379.A0A232F2K4"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="54"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="492" mass="54678" checksum="50A93B245E63CE02" modified="2017-10-25" version="1">MSAQDKEKTATFNVRRKDSGCGVFQSKDPIVQLDKDIEARTGGDDVHGSGSSHPTSYFETLMHHFKCNVGSGIFALGDAFKNAGLVLAPILMVFLGVICVHAQYILLKCNEEVRRRLGSSLEASPGYATTVELCFATGPLAVRKYSVFMSFIEANQRRDCVLAQCHNYMFYLFRKSVNLFLCITQLGFCCVYFVFISSNVKQVMGVWGVDLDLHVHMAIMLVPILLSTWIRNLKLLVPLSSLANVLIVFGYVATIYVISHDLPAISERRYVADWSQLPLFFGTAIYAFEGIALVLPLKNEMIKPKNFDRPLGVLNVGMIIVGFMFIAIGFLSYLRYGEEVAGSVTLNLPEKELLSQCIKLAISLSILLTYALQFYVPIGIMWPEFVHQFGPFNYPVVGEILFRTTFCLITFILAEVIPQLGLFISLVGAVSSSALALIFPAIIEIVISWQDAKLNKFTFIKDIFILGIGFLGCFTGTYASIAEIIHAFNKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2L4</accession>
    <name>A0A232F2L4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001140">
        <property type="protein sequence ID" value="OXU25004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2L4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="464" mass="51194" checksum="C25E146C162662E7" modified="2017-10-25" version="1">MKGLNILGFKDLLYKFLRQTESFGSKVKRFPYNRQGNFWAVLESLRFGSRGQQEQFLIDEVLQARGSGAGVLRGDFLQVKQQLDSLELVLLGIVEKEAIVDLPELASPLHAQGLHAHFASINGLGKLVEKPGPGSLTPSPGDVAPGGIDGPEDLDLALESVRLSGAFLSIVSGLGLENLRLLGAAPAIQKVPQQRQVAWATISRTYDVELAEGWRRAVDHRCSCGWRLIDLYYLRVPVKPLDLNGGIASRLEFLLASGSNDPLANFGKSLRNDLDSSFDASTHADGLGASIDPGGRLHRSVDQSPTFAVKKLHRSLGTGVVILQVAGDVPPTAQKRLRRGSVLDLHYQDHRGTKAVDRVFLSTARKSRSPRPVDNRAVLVQKIPLTYVDAYIPFTKLNFLKDPANGLLDYDTLTIWCEFKAGSTDNPIDVEGDARNNENNYNSLRLDEFDEFENIMNERDFTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2L9</accession>
    <name>A0A232F2L9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001209">
        <property type="protein sequence ID" value="OXU24728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2L9"/>
    <dbReference type="STRING" id="543379.A0A232F2L9"/>
    <dbReference type="OrthoDB" id="7700470at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="461" mass="54105" checksum="945268283028F9FC" modified="2017-10-25" version="1">MYSPKFESPFTWEIDDEFVLNFDESELATGEELPFFNFMHSIMAIFIYAIIGDYNAAKNNFSTMDDLWNLVDHGQLEREQVSVDTVNHILQSTKYHVLLKLEDFMKEEIISRKELKHVEPSVSVTNISTLNGCKSIAWSIFHETGMEKAISFARLASLGNQSCSLWHFVLGKNLRRFRRETSFLTNPSQKEVNSFLKAYEIHRNPLYAIYLALTYSEDEQNERSKEVCVEVFRKKPESVKIQLKLALCFLREMDLPKAKVCLDFVEQYASDSTMYLHYRGKYYMKLNDYERAASYLKEASKSGVFGADLEYGHCMSKIYPDFNQIVHLLYMEKKFRHNKVHLQNIYMQIAMESYDIKKYEKSLKYFALAVKLIPGSKTLQKFYYKRFFKFDNIFYFINGTLVPEYKSAVNNQDLPIQSVQYLEEINNIHAQILLEPSNNTDKNNEIFLTDETNARSKHSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3E4</accession>
    <name>A0A232F3E4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001155">
        <property type="protein sequence ID" value="OXU24947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3E4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="40" mass="4731" checksum="668D9084E49897A1" modified="2017-10-25" version="1">MWRSPPTTTYGLTRHPAEYHDVARTRGAWKFSHFRELVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3M8</accession>
    <name>A0A232F3M8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-interferon-inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001045">
        <property type="protein sequence ID" value="OXU25364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3M8"/>
    <dbReference type="STRING" id="543379.A0A232F3M8"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF71">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26218" checksum="40BAEA38E4C2CCF0" modified="2017-10-25" version="1">MRSYNLLIKIFMAVLVLVIFWQISNLWKSATPEKSELEKLIEKQQIQPVVVTVFYEALCPDSRSFIKHQLKPTFDKIEDYIDVNLIPYGKAETIVTSDDYEFKCQHGETECEANMIHACAIHKVLNSRRRLELVECMISNNMHPQAILETCAKGMDELKDIVQCSKSMEGRKMLKRFGDLTKSLDPRVSFIPTITLDHEMDNQILILKNLLHQVCQRLDSPPSECKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F416</accession>
    <name>A0A232F416_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001008">
        <property type="protein sequence ID" value="OXU25514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F416"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="237" mass="26761" checksum="AE878D916801C664" modified="2017-10-25" version="1">MKSCSWKQCPYVNAFIGSNKNIEMYHSTNNDLSIILAGNHLNGVNLNSDYDSVFCSYINQSTILAGNVATIDHSNKKCTITRGKENTVTFDENESVDEDNEIDVLNTNIDAICDQSEMFYDSLECKIDSSATTTETVNNNFQEGNLTRLIDVKSSEQSNGTFRVQICIKGFKEENKPVINLKFKQVTHDNFNKKARKSKLANFNRSSKTIEKNKAIVGTSNFEDFDNKENYDPKNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F469</accession>
    <name>A0A232F469_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000981">
        <property type="protein sequence ID" value="OXU25626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F469"/>
    <dbReference type="STRING" id="543379.A0A232F469"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22466">
        <property type="entry name" value="KH-I_HOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000055">
        <property type="entry name" value="protein quaking isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="216" mass="23874" checksum="2D7D74EFF9D80FC0" modified="2017-10-25" version="1" fragment="single">CSLVFCFSEIAKVRASLFQISGVKKDPLILPEAEGEVTTLTEKVYVPVKEHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLTDELHVLLTVEDTENRATLKLARAVEEVKKLLVPVQADGEDELKKRQLMELAIINGTYRDSNTKVAAATAGDPHGLIYAPYADYANYAALASSPLLTEYATADHSGGLFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F479</accession>
    <name>A0A232F479_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001014">
        <property type="protein sequence ID" value="OXU25485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F479"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="420" mass="48284" checksum="69C95156F1382B5B" modified="2017-10-25" version="1" fragment="single">KYFLEAGRRRRSSGSGLKYSRLDRSHGAVLVRKIFAPFEVDLTQIHRSWFSHLASPVQQRADSNRFTHGYERNSQCIFHPTNSAIPSPQKRRSELAVQLLFLCIGEQLLSYSEGENIQHSSVRRIATAAIFQKRPGQIASGQIRFCDTEHQRLGALCLRRRRLMPTGWLFFLLHRKSGKIIMAEANNGFLKVKKLSTFKEPYSSFNYSVEIKKENQNANQQIEAEINEEDHDFKELMKDLQTQIIKNQSGIMYHTLNSVRRLRKQGKNVKSSYSQGKYCFGSTQMLSEEGKCNIFESKFDNIHRGADPMKKIRKSCYRCTKGVSTVIKSHEARRRVLSTFCLRSRRRCCSFGPGPARKALTKLRVLSRWFGATASTWARYFCIVHSRLGTGRLGRGSSLCNDDICYEFFMGVYRTAADVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4K7</accession>
    <name>A0A232F4K7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7</fullName>
            <ecNumber evidence="11">1.14.11.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_010174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.63" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01000983">
        <property type="protein sequence ID" value="OXU25615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4K7"/>
    <dbReference type="STRING" id="543379.A0A232F4K7"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106155">
        <property type="term" value="F:peptidyl-lysine 3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000059">
        <property type="entry name" value="jmjC domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="139"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="341" mass="39812" checksum="AFE1C28AA59CF18E" modified="2017-10-25" version="1">MCELEQSKILNAFQTLSQESKELYIPTEIIEIEKAISPLDFYRNYVSKNIPVVIRGGIKHWKALEKWSIPYFKQKLANKLVTVAVTPNGYADAIAKEKTLHGTNDKEVFVMPEERQMTMNNFLEKLENPRDDSIFYIQKQNSNFEDLFELWKDVDSDIKWATEAFNTKPDAINFWMGDERAITSMHKDPYENIYCVISGEKEFILHPPTDLPWIPYKNYPCAIYKEVEPGKWITKPINSSVISTQTNESGKSQSDAITENDTDTLSWIAVDPLSPDYKKYPRYKKANRISVKVSKGDILYLPSLWFHHVKQSHACIAVNYWYDMEYDIKYAYYKTLETLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4L9</accession>
    <name>A0A232F4L9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_012403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000957">
        <property type="protein sequence ID" value="OXU25734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4L9"/>
    <dbReference type="STRING" id="543379.A0A232F4L9"/>
    <dbReference type="OrthoDB" id="113620at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="13"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639126-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="172" mass="19646" checksum="4B7E24EE00EF9731" modified="2017-10-25" version="1">MYENLFKSPLTRVFLYGTLKRGEPNHTLIANKENGFAKFLGLGKTIVKFPLVIATKYNIPFTLKKPGIGNQIVGEVYDVDSKMLTKLDELEEHPEFYVRSEEDVLLAPENEIKSGATFEKAGEATKAWIYILPNFRESLLDLPMYESYSSEGSHGLKYFESKDEWARPEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4M9</accession>
    <name>A0A232F4M9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-secretase-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000955">
        <property type="protein sequence ID" value="OXU25744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4M9"/>
    <dbReference type="STRING" id="543379.A0A232F4M9"/>
    <dbReference type="OrthoDB" id="9997853at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902004">
        <property type="term" value="P:positive regulation of amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028010">
        <property type="entry name" value="GSAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026172">
        <property type="entry name" value="GSAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13630:SF1">
        <property type="entry name" value="GAMMA-SECRETASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14959">
        <property type="entry name" value="GSAP-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-secretase-activating protein C-terminal" evidence="1">
        <location>
            <begin position="738"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="953" mass="108116" checksum="14D6DDCF37EFC7BD" modified="2017-10-25" version="1">MEENLAAKLCLLLGDRASEAVQWKLLGQEKDGSLLLGWVENVSSKGHDNSYSVIGRYDRLKGDLQVLHRFSKVLNLIQATVNQCHSLLGYVTKQKFDLNLDESNKNSPVDCEKSTKDDDNEMLHQQFSNQELEYYQAYIIEFKTEEAKIHALESDKLKQVRIQFLYKERSSKSLDKVLVLVHQEYVQMHTILYDTNSDIHTIREIKSEILVKTFIWAQWDATNQVLYHIHHKKAQTSVFTDDAIEKPHKPPCATPTLSGLQFHDDLPHETVLNIPLNLPQSPSSDNCGTYEDDVIPLRIHDCSLDLIVISDYKGAVCVCHHYLYRPVQPPQHVLDSSLSDSNTVHFAYSVTVLHHSCVIHCVVPGIPWTRAKLMRPTFTLYGDSHMVVFVQDFFTHLLEIGLHHQPCCHILSGPLTNVPLHSSYLVPLLNLNDSSDAKTKYSVNAEAKISLNSNSTNILTIDLPTLDLVTLTVPTNFLVDVFKKETSTEVRLGILHYFLCHKNDLETVAELISSVAEKPRSLDIVKIMQEFLIGGSNSLVQKNLLSDAVPLLALVPVTTMEEGSGFEAKINDFNVTLSHEKLWNTSVMLLSPQQRLVPYRSDLWTRLWDLLSKRSDELPRFKPSHIAEKLLVSLACYQPEALSRCSTPMSPSGGFSVTTATLGELMSSRHKYSDGLPFFETESCTASKQEHIVSVNLRELSLHLLKYGTQNALGRTVRGSCTPLQVHALSTRHVASQLETSRLLCQMLCKAANVDARVEPERGFCLIDQLEDSRRWLLFTLLERYRYATESIAFPVPQGFMSFFTYLGYRTLKYSKFLQYVRHSVFELQVDVAKIIMADIGDTKESVFRKLELLSLLPRTRAKRLLNQWLHPMSFMLRAREHAANILSGELCQSRNRLPQHRHHHNGISAFPSTDRLSPLDTFLDLLTAKASLTELDFGLLIEATVTSTEDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4U6</accession>
    <name>A0A232F4U6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ubiquitin carboxyl-terminal hydrolase 39</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">U4/U6.U5 tri-snRNP-associated 65 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">TSAR_009327</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Alberta</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01001008">
        <property type="protein sequence ID" value="OXU25509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4U6"/>
    <dbReference type="STRING" id="543379.A0A232F4U6"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000030">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="24">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="23">
        <location>
            <begin position="141"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OXU25509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="482" mass="56220" checksum="F1BDEA1458093C65" modified="2017-10-25" version="1">MPDNYEDESFNDQRAVVPRLCPYLDTINRQFLDFDFEKLCSVSLSRINVYACLVCGKYFQGRGNNTHAYTHSVAEYHHVFLNLHSLKFYCLPDNYEIIDSSLDDIKYVLNPTFDKHQIALLDSNDKLSRAIDGSMYSPGIIGMNNIKANDYCNVILQALSHVTPLRDYFLRESNYSKVKRPPGDSSYQLIQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLWSKKKFQFTEQGDPVDFLSWFLNALHLALNGTKKKDSSIIYKTFLGQMRIYTRKIPPLELEESQRSELMNTVEYGETVTESPFLYLTCDLPPPPLFKDQHAENIIPQVNLYTLLNKFNAISEKEYKTYKENFMKRFEIRELPPFLILYIKRFTKNTFFVEKNPTIVNFPVKNVDFGDILTPEVKAMHPHTNYELVANIVHDGEPSNGTYKVHILHKATGQWYEMQDLHVTQILPQMITLTEAYIQIYELKKDDIKPTNGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5U0</accession>
    <name>A0A232F5U0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000936">
        <property type="protein sequence ID" value="OXU25843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5U0"/>
    <dbReference type="OrthoDB" id="6338233at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="232" mass="26577" checksum="D356F31B64A478B5" modified="2017-10-25" version="1">MESKKKFNKNRYWKRKYQPRNASASTTVKKPVPNKDEGSNQSEDSEEEYVLKQRLPENGWFPDFDSSSSSSDVESLTTVPSSVSISDAKEKITKETKSDENWFNRELDNVQFNSNVPDTKQYKSIKESEIKLKLSSSDSIEKEHNSSYKLKSETIKKSLQETKKDSKITSDNEEDELEFLLSLTEPVHTGPIILKNNLENERRLAVTSNSSANDKPVKSIDLEKWLDSVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F683</accession>
    <name>A0A232F683_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000911">
        <property type="protein sequence ID" value="OXU25958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F683"/>
    <dbReference type="STRING" id="543379.A0A232F683"/>
    <dbReference type="OrthoDB" id="10263520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="289" mass="33862" checksum="9B84ADDEF0F014C8" modified="2017-10-25" version="1">MLEPSKGKTKISGKYRVRQPIENLKIRLKIVQQKSLLAELFENEGETRDGNFLESESYEFAWQEKVFGPYEAKFYREERNCLTEKQKEYHRRLVDSAEEGSRLYSYVQGDAYYPDLDLLTGKFRSSLSLRNELAAPALKNRKAFADRYNKRVVDEKPDERRIRENHYLYTEHENMYIVVDLSPKDEASAESTDSEALLCAISYDSLHKTLTVSPDFSSDECYSVDGIGMSYDFWIEHVSPRPSAREMQRRREASKRVNCTGYLDQHRTKIQERDRKKPVLSLSYFAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F685</accession>
    <name>A0A232F685_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000820">
        <property type="protein sequence ID" value="OXU26341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F685"/>
    <dbReference type="STRING" id="543379.A0A232F685"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011830480" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU26341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="527" mass="59235" checksum="DE3338A9824999F2" modified="2017-10-25" version="1">MLLTRLVFALSITALLSVCSAYRILGVFPFNAKSHNIVFEALMKGLAKRGHQVDVISHFPLKQPLKNYNDIINLDGSMESLMNNYTIEFVSQFSSLLADVGITAEEYGNRLCHFMGFEEMQKLIKNPPTDPPYDLVVTEVFGAHCYIGFGHVFKVPVVAISSAIEYPWISSFIGNDDNPAYVPNVYHIGTGKMNFLGRLKTVVTNYAAISIFHYLTGESQTESMRKYLSPDIPHIRDVEKSIALTLVNNNPVLSGVKPITPSLVQIAGLHVEGNDQTLPLELKSWMDESSHGVVYFTLGSMVLVESLPVDQIRGIFSSFKKIAPVKVLVKIVDSSKIPFKLPDNVKILSWTPQQPVLAHPNTKVFITHGGLGGIQEALYYGIPMIGIPLFGDQFRNVAAFAEKGMLIQINLKQLSEESLDSSLQTLLHNPAYKKKALYLSKLFREQPISPMNNAIYWIEYVIRNGADSIRSSALQFSWWQLALLDVYCFILFVIVLTLTVIVLCIKFIIRKFSRTPHYKRPQKRKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6M9</accession>
    <name>A0A232F6M9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000840">
        <property type="protein sequence ID" value="OXU26242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6M9"/>
    <dbReference type="STRING" id="543379.A0A232F6M9"/>
    <dbReference type="OrthoDB" id="6044770at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056260">
        <property type="entry name" value="Dredd_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056259">
        <property type="entry name" value="Dredd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF210">
        <property type="entry name" value="CASPASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23724">
        <property type="entry name" value="Dredd_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23725">
        <property type="entry name" value="Dredd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="4">
        <location>
            <begin position="263"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="3">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="58544" checksum="AB8FDC85E75A5ECA" modified="2017-10-25" version="1">MSLVIDAISTIPESLNNVVRFSRERFNPNVLQEIVQDADSLDEMDIMSIIFLFTDQETEIHQLIEFVQNDPATYFNTLRHRVNWEEKLLESLIIIGNIKVIKRLGFDNNEIEAMKVRFVYNVHNVSENLNKVIKSLYFVCSNLETKEVSKLITKVNERLCSPVQLDSNKLWLEVYILHWLQQNYISINEDNPNLNNLIEDLKNIGCLIDLPFNFEDWKTTHRNLQDSSKTLINDNSMPFTSNNTYNQNDNNPGTTRIPWGKKQKRLCIIINQKNFKNKVMYKFRRGSDADEKNLIETLRGCNFEIDEPKRDLTKSQMIDFLDSFNTERYNQYACIFMCILSHGSEGEVVFSDDKKISIDTIRDKFCCEKLKNVFKFIILQSCQGKQIGLVERNSEQSTGRLVTDGLTSPVFYKHFGLFQATLNGFVAFRNEDEGSWFIQDICTELRISTPTIVTEWVKKVKKRVGDRRATCTNFKEIEAVQIPCSSDTISDDYMIPKYQEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7C6</accession>
    <name>A0A232F7C6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_007005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000735">
        <property type="protein sequence ID" value="OXU26754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F7C6"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="985"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1197"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1315"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1410"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1483"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1553"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1586"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1660"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1689"/>
            <end position="1710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1711" mass="195482" checksum="33A7992D83BAD78F" modified="2017-10-25" version="1">MDADNVSLMKLIFMIYFLVLFLFTIFTYCYVTEILRCKSLELSYAVYDCDWTILPAKEARILLLILVRTQHPFEITAGKFASFSLPLYCRILKTSAGYLSMLLAVKKRSEQAASFDVAVGPSRAFLRFVGVWPNPEGSETPFETIQCIIVTLTMIIFANIAQTVKVFMVWGNLNSVIEILTTADMPIFVALMKFLVAWYNRKVLKGLVILMMDDWSRSYSSSNLDSMWRTARFSRKLSAVCIGLAQGTITAQFIMVVVFDVNNKGEAERTLYMISYFPYDTQVSPNYEITWLGQCFSNIFAAGAFSAVDAFFAVLVLHLCCQLSILRKELVMLAGHHKKQGDNGEEFSRKLARIVEKHEYFNSFAKTIEDSFNTMFLSQMIASSLALCLQGYQLVIIITNTEGKLPVFQLIHMIYFTCCFSFSLFVYCYVAEELRFESTELDYAAYDSDWYNLPPKDTKLLLLLMHRSRKPLEITAGKFCAFSLRLYCSILKTSGGYLSMLLAVKDRLSLGFHTAFSVTRFVMRFQGIWPGVDKPRTGISRFQFIPAALMMGFFINAVQTMEMTRVGGDLNVIIDILTFADIPIFIALVKHVGIAYNNKVLYKLLYLISEDWKEVTKESEKKVMWQKARLSRIFTMIEVSLGLGRLFIHTIRMTYAMLHPTSFDPTGKPIRPSYMRGYFIYDSQSTPIYEITWGCQFVATAFGGCAFASADALFVALVFHLCGQLTNLQIEFREVGKNTSRNKLEFVRSLARIIKKHRRICHMVDKVEYCFNKIYLLQVSSSSVIFCLHGYSLVTILFYQDDVVVELIFMTFFTFGFIYSMFVYCYVAECLSTEASASLALSSAIFDNTWYDLPPKHAKLLLLPLQRTGKPLIVTAGKFVVFSLNLFSNIIKTSAGYLSMLLALREKFFPQTMEIIKVWGDLNSVLELLTTSDIPNLISLIKILSVWYNKKVLGLLIMSMENDWKSLKTVFELRVMWKNAKLGRLITLAIYSLTYSTVVTYVVMAVYITAIAYKQEFILTPDNSTKLRPQYMRAHFAYDVQKSPVYEIVWIFQCIAMHVAGLSFMAIDSLFSVLVLHLCGQLINLQERLKNVTQNLTKRHNLSYQLSRIVTRHEQLDRFAKAIENAFNTMFLAQILLSGVVLCLQGYQIVIILTSRDTVQVTELLFMIYFTLCFAFSLFIYCYIAEILRTEVCILKVHLQIIIMINPFVSIINLKIELTQSTEVGNSAYECNWYDLPACETRLFILTMIRSKTPFEITAGKFTAFSLQLYCSVYFENLGWLLINAACRFDVAIQTSRTILRFLGVWPDLKRKESWMYSGHFLIPAIVMFYFVNIPQTMMVTKVWGDLNAVLEVLTTSDIPIGIALFKMLGIWYNRDVLGQLVVSMSEDWKSVKSPEERDVMWKNARLSRLLSVTIIGLAEGTIVAQFAMVIYFNVLEARQYSLTKDNVTARFRPLYMSAQFFYDVQKSPNYEIHWLFQCSSTIFAASAFSSVDAFFAVLVLHLCGQLNNLRKKLKKLPKQISDKGGGAFVEKLSEIVTRHDHLDRFGNAIEDAFNVMFLVQMVASSMVLCLQGYQLVMITTAGDGIPLFELIFMIYFTCCFTFSLFVYCFVAEVLRTESMEVGNAAYESNWYDLPSCETKLLMLVIIRAKKPFKITAGKFAAFSLGLYCSILRSSGGYLSMLLAMKDRLAKALITFIIIGARFFLGTLNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7C7</accession>
    <name>A0A232F7C7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_000899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000733">
        <property type="protein sequence ID" value="OXU26766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7C7"/>
    <dbReference type="SMR" id="A0A232F7C7"/>
    <dbReference type="STRING" id="543379.A0A232F7C7"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17231">
        <property type="entry name" value="TGS_DRG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000016">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="62"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="287"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40899" checksum="C1E0E0D62A94EB02" modified="2017-10-25" version="1">MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRSQLLEPSKKSEKGEGFDVLKSGDARVALIGFPSVGKSTLLSTLTHTESEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGKGRGRQVIAVARTADLILMMLDATKQDVQRQLLEKELESVGIRLNKRKPNIYFKIKKGGGLSFNSTCILTKVDEKLVQMILHEYKIFNAEVLFREDCTADELIDVINANRVYLPCLYVYNKIDQISIEEVDRIARQANSIVVSCNMKLNLDYLLETLWEYLALIRVYTKKPGQPPDFDDGLILRRGVSVEHVCHAIHRTLAAQFKYALVWGTSTKYSPQRVGIQHIMHDEDVIQVMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7N1</accession>
    <name>A0A232F7N1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000772">
        <property type="protein sequence ID" value="OXU26602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7N1"/>
    <dbReference type="OrthoDB" id="7657013at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="576" mass="66995" checksum="FA8C75E1B771D5B6" modified="2017-10-25" version="1">MADSPEFNNWLRQLECPQAFTTDYVKKTLEKGVLGLLWEDLPRIVRPLQEVSEARKNILLYKIKNEPKDWLIQSVKNTVHIKEERKKLDAKIRNAEERWRKQEYSCRQKAHLLEKKKEERRNLQLKKEILKIKLEQMQMQIENCSKMQEICNHLMPPTVDEIPQSTIINCLSLVSNYSGGPEKRKVWSTIAESLNPVRIPILWNALLAARSHYTDFIIHLDIEETEDDSSQSRGIIDTGIAKICSEHIDSVAKRFLRNGRMKNNELTTMEYVEKIEQIIEEQRPELTDWLPLALEVKKLEVLQFEFQKEMQALEEHLPVDSISVDEVLMQLIAEIKTIDSQIADRVQEIQNAFGLLKSSGALITKTKESLVNELEKLQLLQTNEESQWLDIELNTELIDFYNNINVDALRKIMLKRETGAYRQLRTCFAKASLTVDAPICGDKVSNFPMLRVPVFYLIDLYKTFIINASLNKRMSEEVWDINEDFPESPLDSPTTVAFPHRGILDLLRLTDSACQKAQQHSVEFEQILKTWSNQTVREVVSKIFCDKTVYGATLDEWQKRFSMIVYVLQKSNINVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7T8</accession>
    <name>A0A232F7T8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000785">
        <property type="protein sequence ID" value="OXU26519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F7T8"/>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039932">
        <property type="entry name" value="Spink4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179:SF0">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21179">
        <property type="entry name" value="SERINE-TYPE ENDOPEPTIDASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012285609" description="Kazal-like domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="336"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="450"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="598"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="675"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="743"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="795"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="858"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="913"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="993"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="1236"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="1313"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="1377"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="1435"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1497" mass="167189" checksum="70F572440E5654BA" modified="2017-10-25" version="1">MLKTIVLLLLLTVSTFYLWKGIEAMQKNEVKCGCRIPRIYRPVCGEDNVTYDNAGVVRCINICNHTVILALAFESRAQETQVLPEGCVCAATDELDPVCGNNGVTYPNLATLRCANECVKYTMLIAFVQGVQVENAGLEDCQCISTFEYLPLCASNGVTYSNPSMLECAKKCLGKTALTPSALLQEQIDLKYELWNSDSLKDCSCNYTLDLVPICENKDVTYDRKEMSACINKCSKNSTLNIIHNRECSEKSTDQLSSKPTKECKDCKLTNEFAPVCGNDGVTYPNPSYLFCVAECEKPGLLYSHCGFCLPQDKEKYEDNEVMMNDVSKKVSKNLLDSLTTCDCVIKYNLNPICGSDDVTYPNPSMLYCIKKCRKTDLQIKSCGKCLTKDPQELTDSEKASKFTDTVNQCLASCPVPLELNPVCGTDHKTYDSISILKCYNSCTNETISVQYYGTCDDKCKCIADKDYNPVCGSDGNTYANPSTLFCAEKCLKSDLKLSYCGKCNKQKELVSERKEAVIPDTLSKVFHTCGCIFTKEYAPLCASDGTVYGNPSIFYCARQCMKSDITIKNCGYCNKSNEESSVKAVQQTTSKNFKSLSSPFLKCDCVATSTLYPVCGTDGVTYPHPSYIYCTKNCKANDASTEDLQLAYCGTCKEGGLEIPKPDKAQDESLSESLNMFEKCQCKITREWNPVCGINNVTYGNPSIFYCSNKCIDSSIHIKHCGVCREKDNPKPLNINNFDDDDDDPNKCRCTATREYKPVCGSDGNNYANFVILECIKNCTNQNVYIDHYGPCHEQTRPAVSKPCRCAVNYSYTPVCGSDSETYPNEQQLNCAISCKNKNLYKMHDGPCNEAAKPEKPSTPPQCACPISYEYGLLCGSDGEDYPNQSSLQCHNRCNATNVYKVHDGPCQYPTEPGDPPISKRCACVHTYDHTPLCASDRKTYGNPSQMNCANSCYKQNIFKLYDGPCNNEAISIVARSKRNPQFNNALQSSMNNRVSGCTCFVKSNYEPVCGTDGKTYPNLSRLSCNWCYRRYIYVDHYGACRDKASAAASRICRCVVVNEYSPVCGSDGETYPNYHQLNCANSCNNKNVQKMHDGPCNKVTKSETPSTSTDASTEDPEVSQCTITQDYDPICGSDGKDYSNPSFLACHNIYNKTNKVQKVHDGPCNQPTEPTDIEPPVTPLRCRCAYTYEYGLFCGSDGEDYPNNSYLLCHNRCNGTMFTLTYADAQLLLLQPISEAILSENSYECSCDFIYDEYDPVCGSNGLTYSNPSYLYCDQKCKDPNLSAFRKGACSEDATKLLASTNDSWTPYERMKNFNRCNCPKSLEYNPVCGTNGITYDNPAQLQCEKKCRQPQLNIARYGLCREEEYFKDPLPFFTDAIKRCDCIYRNERDLVCATDGYTYPNPSTVSCVTRCNNPSLRIVHYGRCRENQKPHNYGAVKCKCTPSSEHYQPICADNGITYDNLSLLYCARECLNRNLKIVSEYPCRSYLNVDERKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F897</accession>
    <name>A0A232F897_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000675">
        <property type="protein sequence ID" value="OXU27064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F897"/>
    <dbReference type="STRING" id="543379.A0A232F897"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="2">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="570" mass="62950" checksum="F3739901876F2DAD" modified="2017-10-25" version="1">MDAGINPRSLAIMEARINSRSLRGANIAVFTATNLSESDKTLFHHNMQQDGFSIMGSSKAMIPNRISFFLGLNGPSVNMDSACAGSGSALERAYHSIKAGHCDGAIVAGGNLSLHPHISCQLKALGNFELFQLLIFMFKINQKEKIQTIITFTFFLRAGLLSADGCTRSFDDSGDGMTRSDGIAVLFLQRESDARRIYHEMVNVSSMHVPCYNINNIMYPKSEPQAELMNELLKESGVSPKDVGFVEVSGVGIKDMDADELNAIDAVYGKREKPILVGSVKSSVSDAISANTISGIIKMIMALETGQIPPNLHYDKPNSKALGLKEGRIRIPTEMTSWSGEYYSVNTTAISGVFLNALLKPSKIEKKNNGVPDDDLPRLVIVSSRTEESISSLLNFVQTRPLDVELLQMFYDIFQSEIDAHLYRGYAIVPAKGSCSNGREETINPLYRRGKTSDLVDLLWNGIAMDWNGLPVFEATIRKCDAVLKPHGFDIFKIITDKDSKTFDLIINSFVGIKEGERAVEINLNGEEYKYLRGNVVDGKVVLPVSLCLVQAWEIFKSFDTHQTTLYLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8D2</accession>
    <name>A0A232F8D2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_008399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000669">
        <property type="protein sequence ID" value="OXU27094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8D2"/>
    <dbReference type="STRING" id="543379.A0A232F8D2"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="88"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU27094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="478" mass="54422" checksum="82FF61ADC30F338A" modified="2017-10-25" version="1">MDTLMEQTQYTAGAQDEICSGGVINCSMTEEPPMVTATADWHNLTVLDNGSFIFDCAEFNGNNPFTTITAQIILYILYGIMFVVSIGGNILVVAAVIRTRDLRPNNLTNYFIVNLAIGDILISIFCVPTSVLSTLIYHYWLLPNQLCAIFNFFQAVAVFVSAYTLVVISMERYLAIMYLFRPRRGPKYAKLSILIVWLLAIVISLPILIVSDVDQPDMRYEVCDFYTCTEKWSSNKQRYSYTIALLVLQYVAPLLFLLFSYIRIAIVVWVKKTPGEAQNHRDKQMNRTKTKTIKMLMAVVIVYTICWLPFNILNLQMDLDKDINRWYGLPYIWAMLHWLAMSHACYNPFIYCWMSSAYRQGIFSMLEYVPIVRRFIPEESNAANNSAGGIPLAGMGQPAGPDDDNQSVITSAGFDGQHNSSLRRINTCTTYVSVRRKMNYNHGAAVRSASFRYNNSLRSSGPMHRHFIHLEVQPEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8E6</accession>
    <name>A0A232F8E6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000743">
        <property type="protein sequence ID" value="OXU26723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8E6"/>
    <dbReference type="STRING" id="543379.A0A232F8E6"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="8"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="265" mass="29973" checksum="873B024F29E29842" modified="2017-10-25" version="1">MEEPHIDNKMFLSTGCSKLDSFLRGGLPRKGITQIYGESGTGKTQLALQFCLSAQIPKNSTDVGGVAYICTEAAFPSSRLHELFKKSPLVKDYAISNEKIFIEHISNTEGLEDCIFQPDRLPTLLSMHKIKLLIIDSIAATYRVEYDLMNVKSRAKSLRKVGYQLQKLSKIHEMAVVCINQLYKSVEKMFVLAQVTAMMGNNYTENLSCKEQPSLGITWASMVTNSFYLYKKFNHRYLFITGSPYLPRKNIEYEIIESGIIGKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8E9</accession>
    <name>A0A232F8E9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein transport protein Sec24C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_008825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000705">
        <property type="protein sequence ID" value="OXU26882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8E9"/>
    <dbReference type="STRING" id="543379.A0A232F8E9"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000020">
        <property type="entry name" value="protein transport protein Sec24D isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="9">
        <location>
            <begin position="543"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="10">
        <location>
            <begin position="620"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="12">
        <location>
            <begin position="869"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU26882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1215" mass="133999" checksum="202AD5D5CDCB5DBF" modified="2017-10-25" version="1">MNPQYMQQQRPPYGPTQANAPYSELNANHPPKGPPDSHSFPSQKPPLGPPPTDNAPSLRPPYYVNNVQGQAPETQHGLPLSQSNQNTLADQMSSMALSGSQRPPSSQGIPLQSEKNVPAMPFPSAVNGISNQNHYPTRDQLSANNLPTENSGHIPQKSLPYQQGPPTSLSPSYGPPTASSQFSSQQQYSGQTSTFTSHQAPNIPRSTSQPAPPTSTDHQSQMPSQNRYGPSSINQADMTGPPLLGKVPPVPMNNQQSFKGSPMPGQPQQSMPGPPQSGSYMNNPPNANRQNLSGPPIPGSNYQGPPPTNQQHIPKPPLPGQISGLSGPSLPGQANLSGAYGQTNLTGPPPLQQNLHTQYGNQIPDQRRYSSSPSMPGQHNSAAPYSHMNHQHSDTGYQGYQQNYNQTGQNNMYANQTSPYQSGLANPTSGYQPSTQTQQARRLDPDQMPSPIQVILDDQKLKGGVFTTNEKGLVPPLVTTKFIVEDQGNASPRFIRSSMYTVPTTADIIKQTQIPFSLILSPMAQVEEGEYEPPIVDMGEIGPVRCNRCKAYMSPFMQFVDAGRRFQCMFCKSTTEVPTEYFQHLDHTGQRMDRYERPELILGTYEFIATKDYCRNNTFPKPPAIIFVIDVSYNNIKSGLVNLLCVQMKKIIRNLPVDVGQSKSNMKVGFITYNNTVQFYNLNATLARPQMMVVADVQDVFMPLLDGFLCDPVESEVLIDSLICQIPTMFGDTKETETILAPAIQAGLEALKASECTGKLMVFHSSLPIAEAPGKLKNRDDRKLLGTDKEKTVLAPQNNFYNNLGQECVGSGCCVDLFVFNNSYVDIATIGQVARLTGGEVYKYTYFQADIDGERLITDVINNINRPIAFDAVMRVRTSTGVRPTDFYGHCFMSNTTDIELASIDCDKALAIEIKHDDKLAEDEGVYIQAALLYTSCSGVRRLRIINLSLKTSSQMAELYRGCDLDAIINYLSKQCVFKLIDSTPKAIKDSLNSRCAAILASYRKHCASPSSAGQLILPECMKLLPLYTNGLLKSDAITGGNGITVDQKSYVMMTVATMPISESVVHVYPRLLPLHDVDPQENDLPPMLRCSIDKFVDDGAYLLENGIHMFIWLGSNLNPQWIQSVFGVTTVAQVDTDRTAIPSLDNPINKRIRDIISYVQSERRYCMRLTLTKQRDKLEMVMRQFLVEDRGADGSPGYVDFLCHMHREIRTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8L3</accession>
    <name>A0A232F8L3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dynein heavy chain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_014339</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000755">
        <property type="protein sequence ID" value="OXU26657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8L3"/>
    <dbReference type="STRING" id="543379.A0A232F8L3"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000411">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000002">
        <property type="entry name" value="Dynein heavy chain 9, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961:SF16">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46961">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="14">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="13">
        <location>
            <begin position="330"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="15">
        <location>
            <begin position="482"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="16">
        <location>
            <begin position="625"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU26657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="104538" checksum="F9B6346713B14DD5" modified="2017-10-25" version="1">MQAQTTLINFTVTRDGLEDQLLAEVVKAERPDLEELKADLTRQQNDFKITLNSLEDSLLSKLSSAGSNVLGDTALVENLETTKRTAAEVERKVTEARGTSREIDAARELYRAAAARASLLYFILNDLNTINPIYQFSLKAFSVVFQKAVLKADPAPEVGARVKNLIECITYSVFMYTTRGLFECDKLIFTSQMAFQILLAREEISATELDFLLRFPITPHVTSPVDFLTNTSWGGIRSLASRDEFRNLDRDIESSPKRWKKLVDCECPEREKFPQEWKNKTALQRLCMLRALRPDRMTYAIAAFIEEKLGPRYVEGRTVEFAKSFEETSPSTPIFFILSPGVNPLKDVEDLGRRLGFTSDAANFHNVSLGQGQESVAEYAMDEASKKGHWVILQNIHLVKKWLPLLEKKLEVAAEGSHPDYRVFMSAEPASTPAGHIIPQGILESSIKITNEPPTGMQANLHKALDNFTQDTLEMCSKEAEFKVILFSLCYFHAVVAERRKFGPQGWNKIYPFNVGDLNISVSVLHNYLEASPKIPWEDLRYLFGEIMYGGHITDDWDRRLCVSYLEELMQPDLVDGELHLAPGFPAPPNTDLVGFHTYIDEVLPPESPYLYGLHPNAEMGFLTTTSENLFRTVFEMQPRDAGSSGGQTVTREDKVKQVLDEILEKLPEEFNMAEIMGKVEERTPYVIVAFQECERMNYLTGEIKRSLRELDLGLKGELTITSDMEDLENALFLDQVPQTWTQRAYPSLLGLTAWFVDLLLRIRELETWSTDFVLPASVWLAGFFNPQSLLTAIMQSTARRHELPLDKMCLQCDVTKKNKEEFTSAPRDGAYVHGIFMEGARWDVQAGIIVDSRPKELFPAMPVINIRAITQDKQDLRNMYECPVYKTRTRGPTYVWTFNLKTKDKPAKWTLAGVALLLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F994</accession>
    <name>A0A232F994_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000642">
        <property type="protein sequence ID" value="OXU27235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F994"/>
    <dbReference type="OrthoDB" id="6126739at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215:SF0">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU27235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32794" checksum="5D9E83142840E60A" modified="2017-10-25" version="1">MPCSAVTLSLASITGIIATALLAIAFATDNWLYTEVKRASIQQHAQKSSDQSLVEQMNSKYYYYTRTQGLFRICYPKDRPPNEEIYLSPVETHCMNIDYFIPDEENQTREFSDDAMARLHMGRSVIALFIVGFLAIFTAFWTGVVGCWKRSPGNITATAILMLLACLLSAGGMGLWHGVEYYEKEKLVGEEYYQQWNNVLRDNTAQWYDWSFYLAWLGVATCLGAMTLFLIAASCLRRERAREQAQNVQYIMPVYPQKQQYAYAGYPAPAAYPGPYYHGSQGYGPYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9F5</accession>
    <name>A0A232F9F5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000631">
        <property type="protein sequence ID" value="OXU27305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9F5"/>
    <dbReference type="OrthoDB" id="6772971at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9288" checksum="C3EC5048DAF77B46" modified="2017-10-25" version="1">MTSTMGLQHQATSQDTVDYAGYLQQHHRQHHLLHERQQQVDQNASFTSTKGLLNGPGQNNCFLNSAVQILTVENIVSNQRSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9T0</accession>
    <name>A0A232F9T0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000643">
        <property type="protein sequence ID" value="OXU27230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9T0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="55" mass="6686" checksum="C3A83A2EC4AC695D" modified="2017-10-25" version="1">MDQLRGLVVLRGWQLRLEHLRLRTSDMRSRIRLCKASIIRRVVCWTTRFNPVYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAH4</accession>
    <name>A0A232FAH4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000604">
        <property type="protein sequence ID" value="OXU27433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAH4"/>
    <dbReference type="STRING" id="543379.A0A232FAH4"/>
    <dbReference type="OrthoDB" id="8111264at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF16">
        <property type="entry name" value="JERKY PROTEIN HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082224" description="HTH psq-type domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="544" mass="62265" checksum="5CB14ACE41EA8EC5" modified="2017-10-25" version="1">MSTCSGWYSLCTLISLLNFPTIAFSTAKRRIKNFSLQEKVKVLDDVKLGRSKAEVRKEYGIGESTLRRWVHDEQKIRDALHEENASRKKLRPDDNPYVGEALIAWYNRCKQQNVQLSGLMLRGYIKYFTIEKTKIVSIHPEKALELNKLLGGKENFTASNDWFNNWKRKYGLPDLTFAEECNNKPLEDSAVSQLTMTLSNAVEEESLLRCQIFKCDKTVLNYKSLPNRRFAGDRITIMACGNADGSLKLPLVVLGKSVKSTTLMNLQNSLPVFYAHQTTLWIDSDVLNEWFDNEFTPRVTEFLKARSLPLKAILIAENVPTDAFQNRPTSELQIHLILHNLSLVIGPMDNESLESIKMNYEHKLLRSIISAQDDGETMADHLQKINLRDFIYWISNAWDEVKPSTIVKCWKKLLADNEESNEVFFDNPQEVNPAVIQDMLRRINDYRDISADDVAKWIAENHETSRISIDNHIIEIVVKDTNEDLVDDAENMCEENKTLTAAEAMNGLNDAIRFFEQNGCASVAEMMTLVKLKEKALSIKINTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAR7</accession>
    <name>A0A232FAR7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000509">
        <property type="protein sequence ID" value="OXU27936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAR7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012036925" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24706" checksum="6C320A382065BB3E" modified="2017-10-25" version="1" fragment="single">ILSSRFSSIAAFSMLCLTFVMINADEAPEVPKDPVEATAERMERRKAIYFTNVFNMCEFVKTILSMVMYTKVFKYFLIEIAELVQDSDSCTECICLHLWAMFNASTLVQQKTHRIILGRVAEQNQQNTIKKNSSIKTVYPTNSGLREDLQQPGIIEKFILTVPEAISAELTHIPSGIKTASAEARQPAISRRPLLLHANSQNKKKVMPRPIKQRNQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBC1</accession>
    <name>A0A232FBC1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000546">
        <property type="protein sequence ID" value="OXU27759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBC1"/>
    <dbReference type="OrthoDB" id="7698744at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="663" mass="75925" checksum="553CD6343D45A1A8" modified="2017-10-25" version="1">MYSLIPRSKNRIQIRSLAKCELGRYLSTACVKFSERRSQGGLFSRLRNVLQHSEYEFSKARFSRQKRCTLRKNSSWAVNAKQIKFNPILLKDLEFFQKACMAFVYKRNASDLSIKNPKPPIREPNMPEGSNKKDEKKKDKKEKKPVMYAAEDSSESQSTKTPTNEIKQIFRNKWGVKLIENVNISDENARTYMKSISSLQWGVNLNSSMDENKLFNTTDKADSSKVRLALVSKGNGEMDKSYVKRPKRQGDEFAVDPNFALYYKTGDEFIDYDEEYYVPMEMSGKEIATAWKELVVNSKGPKAKEDEAKPVELQEVESIFIRPEPPAPKLDVKSIKSSNISKSSSGSYAQTAHFSTCTFFMTPTITGNESSTDSFNPNASAFHLVEEAKNSEETVFSPSILLPSRPLSPIESSYEAFREDNDEFLENLTTSPDTALDFANDDRIMQSITKEQLHSNMKEFEAMKENTTYKLSGLSIEDRAFKNTEQNYDGSIMDGMRLSPLNQFHVTIFDKRQYTSSANDDADEMTTEYTIEGDTVKVNGDPYPYSKEHFEKWRLPKTENFNIHLNIDPEYRNSTKLNKSDKISNKTKNKKNNSWSFTSWFGKSKPVFSHPNHLGENIIDKLVEKPAVVSASKQATEPVPDSLHHFQLQRIKCKQFDDNLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBJ2</accession>
    <name>A0A232FBJ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000497">
        <property type="protein sequence ID" value="OXU27992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBJ2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="20554" checksum="0B42CDD2CF752988" modified="2017-10-25" version="1" fragment="single">SENEKLKIENSLLKELYKELQDCNCDILNQDVVDQEFLQVFLENGYYPRITSITRPSTTNINKGSCIDNFFIKLSKIKYKTFTLSVPFNDHYPIMISLKGIKNNSSHEEHKKINYNKLRKAAERKTVKIVTYPNTLLQNTYAFVKQEQKVEDDSIIHIKEIKRPIESVFTEIDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC58</accession>
    <name>A0A232FC58_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dehydrogenase/reductase SDR family member 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000490">
        <property type="protein sequence ID" value="OXU28029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC58"/>
    <dbReference type="STRING" id="543379.A0A232FC58"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="40885" checksum="1BA52E89459CAD18" modified="2017-10-25" version="1">MERWAGKVAVVTGASVGIGAAIVNKLLDNGLIVVGLARRVEKVKELIDDRPEANKLHAVECDVTNEENVVTAFAWIKENLGSVDVLVNNAGVSRETTLSDGSLADWRNVLDVNVLGLCVCTREAVRSMRECDGESVIIHMSSLAGERVPAVPGFNVYPATKRAVNALAQTLRHELAGTKIRVTVWIYNEYLTHSSRFQTISPGLVATELMANYSAFTPEVLTAMPALLPSDVAEAVSFVLSMPSHVLVQDIVLRPLGESCLALIHQYYHFLGQNDHSKNVYVHSLSPILDASLDDQRWQVDRGAIDQDLNDAEVLLDPLHLIVTLQNMVYLHFIDATSYSDDFHSVVNEELGDGSADSTAGSGDEGDFVDPTVHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCF7</accession>
    <name>A0A232FCF7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000492">
        <property type="protein sequence ID" value="OXU28017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCF7"/>
    <dbReference type="STRING" id="543379.A0A232FCF7"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1600.10:FF:000013">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="224"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="622"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="727"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU28017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="906" mass="101087" checksum="91F522DAD07DE3A6" modified="2017-10-25" version="1">MAESRRSQHGRSKGASGLGYCVLAVCAQRSIAAMTLAEDRPDFAGFRGWIRPACLSTFSAGMEWKIFAATKFRQLRASSPAGGAKRTTVPNDNDGLAELSDGVKSASTSSDGTNSSTTPTRTDSMSDDTGFPLDTADEKDEVSSTVSNLSDITGISILSDDGEGAMEWRNASTWVEKQIQKGTNPRDVLKVLFSDPSEIPERVDDVILWQIVINMMSEPPKRQKLTHVNTMSDVVELIKNSKNIIVLTGAGVSVSCGIPDFRSRDGIYSRLAQDFPDLPDPQAMFDINYFSQDPRPFFKFAREIYPGQFKPSPCHQFIKMLEKQKKLLRNYSQNIDTLERVAGINNLIECHGSFATASCTKCKYQVKSDDVKEEIFAQTIPMCPKCQEQSLPSITDPTSSDNYRDIVAQGVMKPDIVFFGEGLPDAFHDAMASDKDVCDLLIVIGSSLKVRPVALIPSSIPSHVPQILINRESLQHLEFDVELLGDGDVVINQLCHMLGSSFKEVCWRDTVLQEAQKLLPPEFPLSDAWDQSQDTLTNHHFSQDSAQVDQDNFLVQSTTSKRTLRVFEQDEQDESATLDDRPWKKIKSDTDLKELLNDEPISSMTCTKFYSSLEEYYEKKNHTDEDMLKNPSCESDNESVSEKTGSSKSQKVNDEQEDKKPLDDRPWNKEESKKSNDESSEYTEDSKITESECVNVRSLSFHSEYTEHTVKNLTFIEETHDRHLTSLSYTNSPKSLGSSRKSITLSSGESPTTSYESSRATEEIYISEDCHVVPRIDCLRDDSASEGNLDASKTSDKLELKPRHASIDSVMDSALGDSCSSSDCQKGKIDSNDESKRFDKLDHSSWQPIDRESLASRLPENTYYQMKPGKYIFPGAEVYTNFPWNEGVLQIGGLRSALTASQLSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCJ6</accession>
    <name>A0A232FCJ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000437">
        <property type="protein sequence ID" value="OXU28395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCJ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF48">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="75"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="479"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="754" mass="87732" checksum="6A06F9387FEE9DB8" modified="2017-10-25" version="1">MGVHEFLTIETCVNNEIQSFTFFVKSLVPSHNDFEELTFLEESNFLKNVIPRLLEGHLDLQTWATKYYLSNSKVIVLENLKSQCFDIVKDVLLIGQLQSAVISLARFHSSSILLENKMKKPLNELYPGFFEEKLLKNIVAVGWYRGLDQGRRSRGSEAIGLEPKHDTAAYTLMLERIKPANNQRNLMFKDNQDGTSSCRFVDFQMVIYNCYVMDLVQLIHLNTNEGVRKKIEEELVELYHSVVTKNLRKGGLENGEIIELKEIFEDLNERRIFGLVISAQYFPIILLGKKLTAEFTKDSGKLKKYIYRSRKNFVLQCMRLSQNYRKRIEESVRELIEYMEESGKAHQHQFNNGSICDNLISPDEVSTILDKLYPSSNVKILNYFLEPFSNEPFGYLSMHNLLTVKILDPDESRSSQLEEAKTCTLTFFVKSMLPSPTVCQKLLFEEESKFFRDVVPQLLENYKSEFWAAECYLAKQNLIVMEDLRVRGFTMPSIRLSENQLILSVASLARFHASSMLLEDKLQEPLDKVYPGHFEEKLLNIEGVGKKWLITGMEAIEAVAKSFRLDPTNCWSAYRESLDKVKPVPGQKNVLSHGDTWCNNMMFRERMYTCRLVDFQMVTYRFYAVDLVQLIYLNVDRDVRCKLENDLIQVYRKVLNQCLRSHGYGGRLMSSDELIKDFEEMRVVGMILAALIFPIALLNGELKEEFTKDPEQLKRYMYVNRKDFVLSAFEKSDEYRDKIMGIVKDLTDFMNSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCN1</accession>
    <name>A0A232FCN1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000461">
        <property type="protein sequence ID" value="OXU28209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCN1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="302" mass="33869" checksum="3F2BC907C8D694AB" modified="2017-10-25" version="1">MDRQLLTAAVDSLDDFLEFLDIIGLLVQFVDQLLDYHLLDLVGLALRLRGFRVPFDFALDLRLGGLLYHRDRVLLGLVALDFPQFRLLLLRLLYRCLVRWRRRLLLELLVDDGGRGVPALLGRLRLLLDLLQLLPLAAANLLDDLHGVVEYLDDVLLDGVPVDGLLADLVPKTADVAVELDLDRLLRELSVLPVDRLLDEVEKKEEEQPAAQRNTIGASSSSLSNLRLRSIISTEIPNTNRYPIPCPKLKIQMHWAVHLINCDSANLLSILRRSGQATHMRAVRGDDPVIETLLPPASASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD32</accession>
    <name>A0A232FD32_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein disulfide-isomerase A6 homolog</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_006419</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000441">
        <property type="protein sequence ID" value="OXU28368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD32"/>
    <dbReference type="STRING" id="543379.A0A232FD32"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02983">
        <property type="entry name" value="P5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03001">
        <property type="entry name" value="PDI_a_P5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000050">
        <property type="entry name" value="protein disulfide-isomerase A6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012398581" description="Protein disulfide-isomerase A6 homolog" evidence="14">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="139"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="397"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="437" mass="47883" checksum="8AD5E20E0BB10AA5" modified="2017-10-25" version="1">MQEMPIGLTLLLLGAVGVQCMYPSSSDVVDLTPNNFDNKVLNSDSIWIVEFYAPWCGHCQQLKPEYEKAATALKGIVKVGGVNADDHKSLGGKFNVRGFPTIKIFGADKNKPEDYNGPRTAQGLVDAALKAASEKARSTLSGKKSSSGGSKSEGSKDSKDVIELTDENFDKLVLNSEDMWLVEFFAPWCGHCKNLAPQWASAASELKGKVKLGALDATVHTIKASQYEIRGYPTIKYFAPGKKDSDSVSDYDGGRTSSDIVTWALDKLAENVPAPELTQIINEKSLKKACEDKPLCIVSVLPHILDCQSDCRNDYLKILTTLGEKFKKKMWGWVWAEAGAQPHIEEALEIGGFGYPALAAVNIKKMKYSLLKGSFSQDGINEFLRDLSYGRGGTAPLKGTELPKIYETEPWDGKDAEPPQEEDIDLSDVDLDEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE75</accession>
    <name>A0A232FE75_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000380">
        <property type="protein sequence ID" value="OXU28778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE75"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012059430" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="10602" checksum="C947E7C9BA367CA8" modified="2017-10-25" version="1">MFPRCFTYVGVIALIVAVASIRASEATDDTEVQDRVNPAIKAVSKLLGKLFAGAAAGCLIQAATDCKDHWKHPTEALKCGVSVAQKDWLKNNKGKCAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEN0</accession>
    <name>A0A232FEN0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000337">
        <property type="protein sequence ID" value="OXU29112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEN0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="83" mass="9488" checksum="18756EA6B8C49D6B" modified="2017-10-25" version="1">MKLTQVAFITQKTQFNYYHRLTQTASVMVGHGLRICATLSACLLPVSRTETTILTILLSNTTRIHVIRLQISQAFFFCPLLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFC7</accession>
    <name>A0A232FFC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01000294">
        <property type="protein sequence ID" value="OXU29402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFC7"/>
    <dbReference type="STRING" id="543379.A0A232FFC7"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="70"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="409" mass="46123" checksum="F7144A91D63141B9" modified="2017-10-25" version="1">MFRKVPVKLAKNADRSYSIPKAVYTSKLSFINDDSNSAIPTYQVMSNERSVKSLKIQDSRINKDSLVKAYKTMLQLHTMDSILYESQRQGRISFYMTNFGEEAVQIGSAAALLAEDLIYAQYRESGILLWRGFHISEFVNQCYGNHEDKNKGRQMPVHYGSKALNFMTISSPLTTQLPQAAGAAYSFKLRGKKACVACYFGEGAASEGDAHAALNFAATLACPILFICRNNGYAISTPSHQQYNGDGIAAKGPAYGINTIRVDGNDIFAMYNATEYARNYAVENQKPVLIEAMTYRVGHHSTSDDSTAYRSNSEISSRANDSPIARLRSYLESCNLWDKSKEEELSKESKRKVIEAIAAAEKKLKPGWKDMFEDVYCEMPKHMRKQVDLMETHMLKYEDKYPISKYIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFW2</accession>
    <name>A0A232FFW2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000270">
        <property type="protein sequence ID" value="OXU29592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFW2"/>
    <dbReference type="STRING" id="543379.A0A232FFW2"/>
    <dbReference type="OrthoDB" id="8196194at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="444" mass="46968" checksum="8CFDC67244E2ED11" modified="2017-10-25" version="1">MESVLKVGRTVSGGVYLAAGLLARGARRILAAIPLLGISNADDDGDDITVDRITQAQQAAPTASALAEALKLPHETQELKLREEELNEPKFVALATEQPPVVEEVLTIRTSPVVETAPVVEAAPLVQVAPVVESAPVVEAAPVVEEITVVETEPELPPPAPVQVAEPEPVDPEIAKLEEELKKTLEAQLEDVPPPLPDSPVPLEVIASKIASFAATTMQDAVETILDTLPEPPTAEQTLDSLDMLPPPEPQEQPEQPESNDRPANDEEDSEELPLPPSQQEEILTDEVVVSDAAEDEIHVQESSQPETTITTITTTTTTTTNDVEEAPTPVLLNGIGQHDDEEEDEEEPEIVQNAPEPEAAAVVEAPTENGVADEAPKSPPPAVPVEAPAPAPAITEDVASVTKAIEEIDISEKAVAAAVNETIESAGVNEIVADSVHQNNLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG10</accession>
    <name>A0A232FG10_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000319">
        <property type="protein sequence ID" value="OXU29257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG10"/>
    <dbReference type="OrthoDB" id="7701610at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="390" mass="44670" checksum="06F8E8C7C12BBEA5" modified="2017-10-25" version="1">MSESVAPCSSRVAMSIAFKRARHKFPKNFGLMSNAEEAYESPEQHEDSPSKPNNEQEPRHVETRGIGSISDKLESSLVDSLDAVEISDKVEILCDHCEYYPENFESADQEVISPLTLEEKIEHNCDQRQSNHPNEFVIAREASAKNDRLNAFHESNRSINLAWKEESDHCENMDSDVEGSRIYEIPQKFYERRSESTPSRSKANHKCKKSSTRSSTRHSCGSYFAPMNHACDDDGLLHSPDCPQDHIANSMHIHEPSTASCRRPSSHRKKRERCSTCQRRYSSPSKIPSTRRADTCSRDSGIFTSVRYENDDYDDGLSNNLEHKDSLCLLQNKYKMGSRKRGECSKREDKYSTKRPEQIDGASEEDDKETKKSSSRKFCRRLLNRCSNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG87</accession>
    <name>A0A232FG87_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000287">
        <property type="protein sequence ID" value="OXU29468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG87"/>
    <dbReference type="STRING" id="543379.A0A232FG87"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="206" mass="22990" checksum="9AF567406FF1F626" modified="2017-10-25" version="1">MADISFSGRAYAKIILHAAKYPHCAINGLLLGKQPKSSSGTELQIVDAVPLFHVCLHVSPMSEVALTMVEQLASSQGLVIAGYYLANENINDISTDKPAHRSISEKIVENFSHAVIAVVDNKEMTIGMNTNPLRISQFSEGKWKFKEKSSINYEGGAGLLEAMYNLMRNEEYRNLVDFDNHLDNISLDWRNLKLNEAIDDALKNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGK9</accession>
    <name>A0A232FGK9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">DNA-binding protein SATB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_011799</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CUT homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000252">
        <property type="protein sequence ID" value="OXU29693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FGK9"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000004">
        <property type="entry name" value="Cut-like homeobox 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000027">
        <property type="entry name" value="Homeobox protein cut-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="15">
        <location>
            <begin position="298"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="15">
        <location>
            <begin position="448"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="577"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU29693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="68907" checksum="7B2FE46FFECDEF52" modified="2017-10-25" version="1" fragment="single">MPAFARGPQEPGAGGNGNNGNSSSGPTSGVSQDMSEERIAHMLSESGHMQLSRQSEADTSNDADSKSPSRLNCPSPFGKDRSMDSQNRRLKKYENDDIPQEKVARIYQEELAKIMGRDMRGPRDFPARPIDSNEDSIVILIDRSAMFPHFFSGQNLQGMERTQEEIRMALDAYHRELQKLNVAQGLPYPPQISGLLALQQHAIQQHHLATNGGSGTXXXXXXXXXQDLSLGNILRSKMINGVSEEEKEKMEEAMRHAGSAFSLRMASITNSLISQPSTPTHHSANQRPLKAVLPPITQQQFDIYNNLNTEDIVKRVKEQLSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDDNAVHKLVASQYKIAPEKLMRTGGYGGLPPCGTPMKPMPPTKLVQEQLQNAAKAQAAVQAAAQAAAAAQHQQESQLQLGPPQQSPQLPTITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDPHNVDRLQSLKNERREANKRRRSSGPGHDNSSDTSSNDTAEFYHAASPGPGPGPTSAKKQRVLFSEEQKEALRLAFTLDPYPNVATIEFLASELALSSRTITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHF8</accession>
    <name>A0A232FHF8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="15">3.1.3.57</ecNumber>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_003788</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="15"/>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000193">
        <property type="protein sequence ID" value="OXU30112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHF8"/>
    <dbReference type="STRING" id="543379.A0A232FHF8"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01640">
        <property type="entry name" value="IPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000006">
        <property type="entry name" value="Bisphosphate nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000023">
        <property type="entry name" value="Protein CBR-TAG-231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0452">Lithium</keyword>
    <keyword evidence="7 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU30112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="306" mass="33004" checksum="57B975D3E68403C4" modified="2017-10-25" version="1">MAQSGALITRLVASSVTAATRAGKIIRDVMSQGELNIVDKGTNDLQTEADRSAQRCIVTSLSQQFPGVTIIGEEEPSNCEVPSDWVVTDMDQEVLKVTLPQHLENAKAEDLCVWVDPLDGTSEYTQGLVEHVTVLVGVALGDKAIGGVIHQPYFKNSENGTWGRTIWGIDGVGIGGFKPIPPPEGKRIITTTRSHCDSTVQGALDALQPDEILRVGGAGHKVMLLLEGKAHAYVFASKGCKRWDTCAPEAVLHSVGGTLTDLHGERYVYNSKTSYPNNGGVLATAPGQQHQWYLARIPNEIKQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIJ7</accession>
    <name>A0A232FIJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_010230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000145">
        <property type="protein sequence ID" value="OXU30584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIJ7"/>
    <dbReference type="STRING" id="543379.A0A232FIJ7"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF226">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="5">
        <location>
            <begin position="192"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="46935" checksum="889EEBB708D63F5A" modified="2017-10-25" version="1">MACSAMRYPLLRNPTVRHYAAAAAAQCSPMTNANIKVLGNKVTIAAIDNNSPVTQVSIIFKAGSRNETYDTQGISHMLRICTGLATSRSSAFGITRNIQQLGGDLTTSSDREHVSYTLKITRNNLGPALKFLEDVATAQVFKPWEVSDETPRLRYEVSTIPDNVRLIELLYKAAYRDGLGYSLYCPKRQIGKISSETLRHFVSSNFSGPKCVVAATGIPLSELEMFAASLNVSSQDSAIPASKYHGGELRKERNSQLASVAVAVEGAALKNQKDSIAFAVLQKAAGDGPKVKWGGCNTPLWKAVATKSQDPFAIVSFNASHSDSGLFGFILSAPGESAGELVKAGARWLRAPKLSDDDIARGKATLKTLVLSAGDNSSLLHESVGHQVLLSGNALTPDAIAAEIDKISPADVKNAANQLSKGKLTVASIGNLSTVPYADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIT7</accession>
    <name>A0A232FIT7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000144">
        <property type="protein sequence ID" value="OXU30592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIT7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082225" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10780" checksum="07A49DB327789709" modified="2017-10-25" version="1">MQWLKFCCFFFLLMSVTEAKPHRGDIPVEDAILQGDDYRDDGVDLNDLLITDNPTIDSSKNTDDYDDEDYGSLLTSEELEELKTKIKSATNWPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ03</accession>
    <name>A0A232FJ03_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000147">
        <property type="protein sequence ID" value="OXU30563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ03"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008750" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="47" mass="5350" checksum="B319D56DDC1D0A3F" modified="2017-10-25" version="1" fragment="single">NFIAQTVKIRKSCLFVTKVVLICTVGLADERDECDKHGAKKDYISHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJA8</accession>
    <name>A0A232FJA8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_006313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000116">
        <property type="protein sequence ID" value="OXU30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJA8"/>
    <dbReference type="STRING" id="543379.A0A232FJA8"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257655" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU30821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="74582" checksum="A9EF341705E28D9A" modified="2017-10-25" version="1">MMRCLSPVLIASLLTNLYSTKGNKYSLKKHFGTTTPENDESTVMSTVFNHCFPNQREPIIQISNKRDEYIAKLSKTNVVSLLGLKISDTMDKYLEEKKVYKLSTSDPLFLSHPAKKFLVVGFDSNTLPLALHKLRNSVWRNEEEGHYVIENIQAHDSCKSAYMHLKLVWEFGILSAVFICRDLNYNILVYSFNPFTNQTHGIWKTSRSYKQENGHSFTIFENPFNISDSSWLCKIFSSNKVSDVAGFPINIIGFPIPNINPYEENAELLKIRGMAGEFMDIILIKLNATPNLTVADPTARGIIDENGVPSGTQKDVLRGKYDMQMNSELQRGLWHNEINILIYSGICYVAKKEFIQVQKYFFTIFSLNVWLVLGVMWAMIIMIFKSMLKKSYTAICFEMLRTVTGVGMSYMPTSRLRQLIFINFIFLSMTANFFFQGKLSALQTAPEYSIDLEEPMDLIRLNYTLYGEDQYQQHMYGTVFASFFKPINSTKQCIELLEKRPKIACAIDCWSKGFNVPNSNLMYVMEDDNYRKPFVVMVRDGFSLHKEIRRIYSSMFSSGITDYQKQKINHRMRLTQKPAGWTKGDEYMIPFYKKYLAFTFLQYGYLLSGTVFLLELITDWIDKYVTRVIIVLSWAHVMPRFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJJ4</accession>
    <name>A0A232FJJ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000129">
        <property type="protein sequence ID" value="OXU30710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJJ4"/>
    <dbReference type="SMR" id="A0A232FJJ4"/>
    <dbReference type="STRING" id="543379.A0A232FJJ4"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13291">
        <property type="entry name" value="PH_ORP10_ORP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF141">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="202" mass="22500" checksum="AB466464CE58ED2C" modified="2017-10-25" version="1">MSVQNRYPYEGLLHKYTNAMKGWQYRWFILSPETGELHYFLSESEKNQRPRCSIYLAGAVIAPSDEDSNTFTVNSATGDMIKLRATDARARQEWVDKLRAVTEMYTRAIASSHPPLPPREHSGSLRASNSGSGGSGSVAKLEVLDAFANCREQLNKAEKQSQSLAQSIESSSLNLDPELLLLKATAHATVYTLNQCLNILYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK84</accession>
    <name>A0A232FK84_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000106">
        <property type="protein sequence ID" value="OXU30909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK84"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="28" mass="3298" checksum="D52816AB344A04BB" modified="2017-10-25" version="1">MLCSLNATENSGPVKQRRFPKDYRRDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKT7</accession>
    <name>A0A232FKT7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000071">
        <property type="protein sequence ID" value="OXU31282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FKT7"/>
    <dbReference type="OrthoDB" id="10029135at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000315">
        <property type="entry name" value="CaDHerin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000363">
        <property type="entry name" value="Dachsous cadherin-related 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000381">
        <property type="entry name" value="Protocadherin 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000403">
        <property type="entry name" value="Protocadherin 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000275">
        <property type="entry name" value="Si:dkey-30k22.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1149"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="56"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="166"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="381"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="481"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="582"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="683"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="794"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="912"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1249"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1249"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1261"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU31282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1355" mass="149165" checksum="3371DAFA990C08E1" modified="2017-10-25" version="1">MSRCKILVFLPLQDRAQRSTERFTSTTTLTVNIRDDDDQDPSFIYKGCMLLNGACINPEYSASVSSGVLSGILNISPEKIQAVDMDSINAPIRYSFLSGSPGNYRDFFEINPSTGAVKQIRAVDTTVTKKFDIIIKAVEDSEAERSATAKLSITVKPVDSNPPVISASSIEGYVDENAPVGTKVTDAAGNPIVLSVSDADLGAEDPKPEYTFELTTTFFSIDKAGTLVVNEENLDRDPPSPGRFRFQVVARERSGLAASSPLSFVVTLNDVNDNAPMLPMTPPITVQAGETKREVIKVEATDNDDGPNAEITYSIYHVSNNGLQKFKIDPKSGLIESVGKLNAGEQYSITVQATDNGGKYSQTIVEVNVIPGPNTRSPVFQQQVYEVQVSEGASINSTVATIIAVDPENDPVSYSIVSGNDLRQFAIGDKSGVITVIRKLDREDLTRYQLIIKAEDTGGLSSTCTVNIKVTDINDKNPEFEGLPYEFSVKEGEARKLIGRVHAEDADEGINAEITYFAPDDIPFTVDPETGDVLTKLALDYEQNHEYKFVVTARDGAPDPRLATATVTVRVIDVEDEVPIFHQSSYEASVKENVPDYMVTHVMADDPDSKKQVTYVIKQGDTDLFSIDPKTGIIKTIRGLDYERETQHVLIVGTEENTSSLPGATTRVVINVQDVNDIPPVFTMVPRPVTLDDNVPIGASVVNLIATDSDGTAPGNQVRYDVIGRGIAGKYFVIDPDSGVLRVRDDLRKVTDTEFQVDVRAYDMGDPQLSSVTTVPVYVRHVAGPPSESGLGFAEDSYNVDVPEDAPAGTLIKVLSVINASSRDASLLDCEIYEGNEERLFRANITEEKNCALWLEKAELDFESTESYQIKIRLQAAAGLIKSGRNITMVKIQVVDVNDNKPEFMFPQANLTKDRYFANVPLAAHFDSTVLEVKARDKDNGKYGKLEFSLVFDNEHNRASDFFAIDPTSGIIRTTANFDTVEPRELPFRFIVQAKDNPNSTNNSNVVEAPVIVNLVGPDNFLILTIENASPESLQKDRAKMARVIEDKTGLLIEIEKIDSRRSLSVNNTIEVRHHDSDIWFYAIDPESEKILLRNSSLLHRLILDRPAMSNITYDLSPLLRATAVDIHAPVMEPEPARTHTAVAFSGEVFPYALIIIAFVILVLGIAGIIYICVSWSRYKAYKERMQRMYVVPRYDPVYVEPNLKEYETQVLQMSVPVDDNDSYNDLQLDFSNKNHAFSLDNVSYITKENGESTGQQSPVSSEAATTARASSIVGNHDSHGAHSLRRKGQSNSGGQSVPPGNNRDTPVLNPLYNHDLLSASPSNDNVIFRERKDYSHLGFTYLGEQSPVETTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL26</accession>
    <name>A0A232FL26_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha 1,4-glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000057">
        <property type="protein sequence ID" value="OXU31441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL26"/>
    <dbReference type="STRING" id="543379.A0A232FL26"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035248">
        <property type="term" value="F:alpha-1,4-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="7">
        <location>
            <begin position="225"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="357" mass="40720" checksum="B076C0A7F7EC1677" modified="2017-10-25" version="1">MKMKKRFAVVILFFLMVFLFVLLTNDEILRSMQLPIMGPSADMDVSCYEKLSTRDSFPNFNTPKERTRLASGKNIFFHETSCFESDRSELNCRQACAVESAARMNPSMSVNLLFLSPSPPSNRTARLVDLVLQSYRNVRVMRVQVDEYVRDSPIEQWYASGILGSSHWPRSHMSDIMRYLTLWKFGGVYLDLDVVVTTSLEDLTDFAGAEDWMDVAAGVIGFGATGLGRRVANACLRDLMRNFRGNLWGNNGPGVITRTLQKFCAVEHAKDMTSSRCSGFRVFPPSAFYPIFYKEWRRYFSEQDFNETMRLIQEARAIHVWNKLSATEVVRVGSKVPYAIVAQKHCPRVYSNCGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLW0</accession>
    <name>A0A232FLW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sarcosine dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_012682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000067">
        <property type="protein sequence ID" value="OXU31337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLW0"/>
    <dbReference type="STRING" id="543379.A0A232FLW0"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000008">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000769">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF11">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="451"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="509"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="841"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU31337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="939" mass="104845" checksum="FFE129EAD18344DA" modified="2017-10-25" version="1">MGRSSRVAAAAASVQQTSSASSCATVTGQQSVGALASLISRADEMLRAATSKFAKWNGPFTPRSRSLATSGQLMQGDAAKPAVADLPESADVVVIGGGAAGCSALYQLAKRGVKTVLLERSKLTSGTTWHTAGMVWSLRPCETETQLLRATQDTLAELEQETGENAGWINNGGLFIAHNDTRMDEYRRLVDLGKVLEVGAKIVNVEEACELFPLLDPKSFVGAIYSPRDGVIDPAMMTAALIKCAKNRGAQVFEETPLTRILTDEKTFGSKQVTGVETDRGVIRTNCVLNASGAWSRSIARMVKLDIPLTPMKHAYIVTEPMKQVRGTPNVRDHDFNIYFKVHGECLSIGGYENNPIILRCVPKDFSFGLYELDWNVFNTHLEAMVALVPELATTGIRSTVCGPESFTPDHKPIMGEDPRCAGFFYSCGYNSAGMMYSGGCGETIADWIINGRPMRHMFSHDIRRFTPEQTKDMVWANEKTHESYVKNYSIVFPHDQPLSGRNFKTSPFHEMLLKEGAVMEERQGWERPGWYLKEGTAPIPPYDYYGSYGTSKNENCKYLQLLQQDHTFDFPKHHENIKEEALSCRNNAALFDMSYFGKFYLCGPDAQKAADYIFTAKTDSDIDRTVYTCILNKHGGTEADCTITWILPGSSGVVDPIFKGKALYIVCGGLSSYHTWAHIRRVIAEKGFNVSLHDATHQMGILSLQGPNSQKILQNIVDKDLADEEFPFSTSKLMKANGKLVRAFRISFVGELGYELHIPLQSCERVYQGIVEFGKPWHLKLAGYRALYSLSCEKGYHLWNSDLRSDDNPIEANLGFTCRKDGKYMGSDAVENLRKNGVKRKLVNLHVKHQVPMWGLETVYRNSEIVGYLRRAEYAHTFGYSIGQSYIKHPKDEIITKEFLETGKYEVEILGKMYPAEMHLKSPFDPQNKRLLNIYHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMY9</accession>
    <name>A0A232FMY9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000012">
        <property type="protein sequence ID" value="OXU32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMY9"/>
    <dbReference type="STRING" id="543379.A0A232FMY9"/>
    <dbReference type="OrthoDB" id="8195814at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="213"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="522" mass="61257" checksum="AD23AD19228F20AA" modified="2017-10-25" version="1">MQRCDSRQASTPYYDSMFSRGLRLQLKLELRCRTMFSFLAFLSILKIAQAVEGVIWSKSARNFVPLFSISRFAVLNDERIQRSKDLEWHDFQHEVLKVAYYQEKNLVSFIENDTRISGVVGEVWEILANYLNFTLVPVRLQERNFGNELENGSYDGILGLIQSNQSQIIPRSGIFRNRLSLVDYTVPLWNIRYHLYIKPEWSHDDAWMFHLFSLKVWYTFILFLVVLSIAGYICEKNSFMKTNEKIVYNLQDHIFYTAAIACNQGCVPAELHNRSRLIYICTSMFSWVILIAFSSNAIFLMMNKKFILPFTGLRSLIQDSKYEVVAFSGSMVHKDFKETVSKYYKYSRDIKRVSYAPAAGEIFRKVCFTEDKKLAAFEAEDRHKAIGKNICRLIPTKASYFETWIASAIKRGFRYKRSFDIGILKLSEFGIIDGLRDRWLDWKFDDHEEIPFQSIDMSQVHLIFSILVLGLIMSLLILLLEYLTYFRGRLFVKKKSKPNIPKVTVKPKLPEIDRNRVFHVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNI9</accession>
    <name>A0A232FNI9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNI9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="33" mass="3676" checksum="5E2D0BDA163C477D" modified="2017-10-25" version="1">MAIHQNHLSSASQFAQIIIQSTRLPAHFTLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED86</accession>
    <name>A0A232ED86_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007528">
        <property type="protein sequence ID" value="OXU16306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ED86"/>
    <dbReference type="OrthoDB" id="7700068at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="480" mass="55863" checksum="359EF8869B9D15A2" modified="2017-10-25" version="1">MLARARERXEAREAGDRKSNGKVEDPEKENQQEDKEAAPGEAAKGTAEDKDKEKNPYLPTQQGEKGEDNGPTDGEKEGSLEAEPTEGAREATHVGSSLGSPARSWWPLFNPGPLPRESRTLGIVIPDAKSYTHEDKKEDSTLEIRELGKEIVKMKKERDELNKEWKEKMQKLEKETREVIARNTNLENKIKDGREEAERKVRKLEAELEKLKGKMQLIMLGETDRRGVTGEVDERKRQEIEERNVEAQYAEDYEVDEENDSKEKGSQGRTTGRETQEIDRENREYLEEIPEALEEQERTILHXYLEEIPEALEEQEVEWEIRERKSRKNNVFIRGIRSTGNVEKEVKEIIKTKMGMDIYISRIRAIGGGILLEIEFKNKVELMKRKQMLKGLNIWIEDDLTPREQEIQKWFEKIEESERKRGLEVRTGYMKIKVEGKWYFWNERKGQLENEQVLFRKGTGKEGKGKEDGQNNNMEHSGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDY3</accession>
    <name>A0A232EDY3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01005823">
        <property type="protein sequence ID" value="OXU16544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDY3"/>
    <dbReference type="STRING" id="543379.A0A232EDY3"/>
    <dbReference type="OrthoDB" id="441971at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="44"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU16544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="173" mass="20279" checksum="D00EBCEB5A3996DD" modified="2017-10-25" version="1">MYRRIRERYQWKGIKEDVHNYVRRCEKCQEQKLVRIKTREPMVITDTPSEFFHKVAIDTVGPLCKTTEENMHILTMQCQFSKFCIAVPIPNIKAIIVADAFTRYLFAQHGVPRIILSDRGRSLKNKLLLELSEIYQFILNTTTAYHPQSNGSLEWSHSVLTDFLRNKASCKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EET1</accession>
    <name>A0A232EET1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005227">
        <property type="protein sequence ID" value="OXU16853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EET1"/>
    <dbReference type="STRING" id="543379.A0A232EET1"/>
    <dbReference type="OrthoDB" id="6616761at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="105"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="249" mass="28286" checksum="BECA8F9FAB34C936" modified="2017-10-25" version="1">MATDLKGLEAIKTIMATDLKGLELIVYGSYSSLTPKSLTVTAAYFIDVRKFKEISIPYSVQVKNRVKTIYDNFKTDDCIEKAIESFVKVALKFNLLYFLQKNAIVKVQQCNRYSLDNHKGVTIIAKSDIKARTVIHGLFGVSISLSKVDEHILWTRNQDFSILMTYGAKTPKMFLGSLAFVNHDCCPNSKYFLSSSNLVSLKTTRPIKKGEELFVEYSNNYFGKNNENCECNTCKERKKIQFYLGVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFD0</accession>
    <name>A0A232EFD0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005048">
        <property type="protein sequence ID" value="OXU17065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFD0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="195" mass="22834" checksum="77CEFFDEF158216D" modified="2017-10-25" version="1" fragment="single">EECFQCQLNNFVSIDLKLSIKTIKISILYTSLPKTHTRHFTELLKIDAQDFWFMLVIYFNFLNHYKPLLSNICEWLQKVLTSLSYKLQQFSEKPGVLIPSFSSLRTKLFKWHGNHASGEDSFQCQLNNFVHIDLKFGIRAIKKKNLTIFRINSSHSERSRPGVFSCDAKFQIFGYKIIRITLKTFLSGRLITVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFX4</accession>
    <name>A0A232EFX4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004908">
        <property type="protein sequence ID" value="OXU17260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="344" mass="40351" checksum="817171BD3FA5FFD4" modified="2017-10-25" version="1">MLYYVAKNIAIVIYDSLSFGSGEPPFYDGRPLLNSNSFDVINLLYVDEHRYTAKCDRFFCIPSCNSNIDIIKCVECNREFYGQICFERHKIDGSYKKNNIKICDEVKVCNMCCKRINIYKSKHECGINWCNLCREKHDVNQLCYIQPIGRNVNAQINRKSPKKNLFIFYDFETRQDSAYREHAEIKIHIPNLCXIPANGCGIREIEMYQRYYVAKNIAIVIYDSLSFGSGEPPFYDGRPLLNSNSFDVINLLYDARRRHFDTILNLTGAARNRFFCEQCNKSYRYVDEHRCTAKCDRCFCVPLCNSNIDIIKCVECNREFYGQICFERHKIDGSYKKNNKKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG32</accession>
    <name>A0A232EG32_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004888">
        <property type="protein sequence ID" value="OXU17294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG32"/>
    <dbReference type="STRING" id="543379.A0A232EG32"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64216" checksum="1E4C232BFFEF73C2" modified="2017-10-25" version="1">MVLPGPLQGRPDKENRDTASGRRSTTDRNASNTDKGKDQTQPSGANSLVEFTEALKETLNTVRDAAFGGRGSGYCACASLALNSLGLTSYLDSHELLKNVASKIPFELKSAYNRYARTIVSNAKPLEKLSEFLREEAECAMGSGLLELEAAPSTYGGKSNVTRKQDRSGKTAIVCATLEETLKESHNRKSEVCGHCKRAGHEIRDCKEFAKELYKRKMFLTRQLRLCYLCLRRGHRRPQYNATSRCDFCRKKRHTMLHFEKQQRLTDVRQAPRQGLLRIVPIVVNGPGGSANAFALLDSGSTISMIDEDLARRVGLRGEKLEMAVRDLWDDEVRVKCERPRKIEHAIALSKLELRAQSLPTELTRELRSREKVNFEPYTNARPLILLGQDNWHLIAIEETRPIGDGGAVLSRSALGWTVHGFLMKDRQQLDVAPAAGKKKISDAERILEQTSRKIGKEWENLMYSFTMGKFQVVHKKFDKFEKIKKFERFEKRALTEITCVKSTQPRKGDDLKVLSCTDKKCGWKQDHSKALEEYDAAPLIQHSCFAEPAVKTKKIVNASSIKRCLEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG35</accession>
    <name>A0A232EG35_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004870">
        <property type="protein sequence ID" value="OXU17313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG35"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="26" mass="3054" checksum="E27855524E81BD25" modified="2017-10-25" version="1">MCPRERLPPLNFLAWQSQTSPLAFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGS5</accession>
    <name>A0A232EGS5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004680">
        <property type="protein sequence ID" value="OXU17567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGS5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="153" mass="17119" checksum="F448C3627CE243ED" modified="2017-10-25" version="1">MKIEDASNSAEFDGHLPDITLKYYLFLIDYLEISMTNAVVIDILKSTCSDRLMSGSELSSRNTVRNQSVLFTNAAVDNTILKREMSIKNVILQLLGLFRFRLARSGSNGLLSEIFDFLISSLASLSFDGEDQIRMMTCTSTPFDGGGWIRMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGU4</accession>
    <name>A0A232EGU4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004688">
        <property type="protein sequence ID" value="OXU17553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGU4"/>
    <dbReference type="OrthoDB" id="7680010at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="131" mass="15180" checksum="2AAAB60637869073" modified="2017-10-25" version="1">MILFFFYCKKIGKYSNVYELNRRSVLAMRIVGGGLENLRSFCRVMDFPAPVQNSSFTKIMKLLFKFTCDVVHKFMTDAVEEEIKLTQNSSKETFEVVDSNQEATRRLSIENLEQEDMSENESELTNTPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI13</accession>
    <name>A0A232EI13_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004375">
        <property type="protein sequence ID" value="OXU17985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI13"/>
    <dbReference type="STRING" id="543379.A0A232EI13"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="17376" checksum="27FA53EDD543156B" modified="2017-10-25" version="1">MCNNSRTQLIHLRLGGVQDLFTCQYILLFFDKRKLVFLRRKFTEKDSNGTHLSNVPTRNTPLCHNCYLQAPDGDILCTCDKKKTQWYVSKQLGEVVKEDPFTVSVRLLFQLSGHALGAVESTTHRSNVISFCSGHEIINRMIFCCCVQNVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJI9</accession>
    <name>A0A232EJI9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Organic solute transporter alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_007684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003990">
        <property type="protein sequence ID" value="OXU18526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJI9"/>
    <dbReference type="STRING" id="543379.A0A232EJI9"/>
    <dbReference type="OrthoDB" id="5832279at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38383" checksum="81700014603D594E" modified="2017-10-25" version="1">MDSLAYFGDENFYITGNFSCDDHYLPRAIQLFEGLGNFGVGMVTIASIICAATVYLAVDACSNICYQKETRAFKINACTILSVYPIAALCSLTALALPRAQLLSEGLTQVSLTISMYRLYELLVDLGRRQATKTPSLALKVGPCCCWPCLPLPSSLEMNEANLSRLRITVLQFPFAQGLIYCILLYMSAESPVFAASYAVCLQPFVVISILTAIYGVTIVTKSLQEIAPEAKLPQKTMVLQMVLLFSKLQGFVIKGLVGTGLFPCNPPLTPTVYANVTYDALMVIEMLLLCYAARMIYAADDRPEHQDDNATATDRHQQESVHRNKATNGEAVTMSAVQIPIPPSPKTNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJN8</accession>
    <name>A0A232EJN8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003958">
        <property type="protein sequence ID" value="OXU18580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJN8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="205" mass="23756" checksum="6CD605574A445A71" modified="2017-10-25" version="1">MNSSLTDEMIVQKFQEMSCFPRTRHPRDQLLYTLTVNNAHKQVEEAKLNYHHSRLSNITDVGEIWRELEKLEITISKETTPSRFSTDDLNRYFSGISNDPLAPSVDEQLQSLDSLEYPVHFSFSEITESDVLATVQHFTSQARGIDGIPQFVVSKVMSALEWLVHRQLSRYLETRLFLDDLQTGIKRMNSWSSDQPSVQKLLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJQ6</accession>
    <name>A0A232EJQ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003961">
        <property type="protein sequence ID" value="OXU18575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJQ6"/>
    <dbReference type="STRING" id="543379.A0A232EJQ6"/>
    <dbReference type="OrthoDB" id="7615957at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31561" checksum="E239164A4EE5A139" modified="2017-10-25" version="1" fragment="single">ESKTCKKYRKVKLREGGRRTNKKFERGEEIEGEKSEKKSKGKCEVSGGRWRTPQAKQHRRATLEGEEDLEKRIRTQTNQIENYLQKGSDGFECVFRKKPSTEVSDKEAGRWAVKRRENQIKRGGGQERQRESRRYAKGRSGGGRGKNIRGSGNRSGRGQRKRKRKGREGITLTDAAKRRRRGQRVSPSLFKEKWEKKNEGGTVIGEVKIFCLKFADDVIALADTREGLQSMLNDLGGRRNRRDKWVYEGKELEIVKEYKYLGQWITSTNSYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJS9</accession>
    <name>A0A232EJS9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003941">
        <property type="protein sequence ID" value="OXU18619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJS9"/>
    <dbReference type="STRING" id="543379.A0A232EJS9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36403" checksum="874B86238884F933" modified="2017-10-25" version="1">MLEHAQKYASPIRAKPPLENTNACSTASHGELTEAPSRKNLSTIEQVDSEEESEDETFVHQNLPDKLMEENERLEQAGNKDSQIPVDDGARPVSTDINKQCPATSPLLGIAEPIAANTSLRLLSMRECVTYLKDNIVHFVPKDLNLSTSINNMLTDIIEYKKHCALVKKIIKQKKKDNLKKFAESLHFCSYPNYQKVEGALNKISPPWVQTDPHWMPRCDDNTFLNHPFDFVEFNVALESKNKKSSPGLDGIDFDIVDRLPLKFKLLLLDIYNEMYQKMNFPEDWQNVFVHLINKPDGDSVIPISLTSCLCKLFESLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJT5</accession>
    <name>A0A232EJT5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003941">
        <property type="protein sequence ID" value="OXU18620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJT5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14022" checksum="93CA885EF552C74C" modified="2017-10-25" version="1">MKDSSSSSSEGELLNTQLHSTMRRSVSGQICNEEELDELSRIEKNSTNGAREENYIEQHSETGVEDTSADEDFIDEEWNIENASSFVPERKAKSLSPSPSKSVDGLPEDLIRTNKNNSIPSSTVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK74</accession>
    <name>A0A232EK74_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003884">
        <property type="protein sequence ID" value="OXU18711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK74"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="20963" checksum="613BF5CD56CA896E" modified="2017-10-25" version="1">MSKKSLGKPPVESDIERIEKINEVIFGTHLEGESTTAEEEERSGTAEWHTPKQGRYAYSKSTGRNKKEGKKGRGKGTKPQLGRKSQSVINVIERGLILKRKRKEANETEEKIEKIKARIPPSTPGKSKASKEGEENLEKEDNKEEERTEKIEEEQEMEKTHKEIFEKMNKDGEVRERATEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKB3</accession>
    <name>A0A232EKB3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003834">
        <property type="protein sequence ID" value="OXU18785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKB3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="20470" checksum="EEDB5211F2A3A15E" modified="2017-10-25" version="1" fragment="single">SLTIQSRLVIRNSSDESIPHTHTHVSPRRNKKNRRQQPLIVKTRLEFASPIANYATYSNYNFGSALESRKVTHHAKSTERGYNVPRRTRPSAAALGDRKLMARGEIRVCVCVCVVYSTHYIRSTLFGVISRHFPLRDAHLREIQRRIHANHRHACTLLASIGYSSCTVYMCMRVLRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKZ0</accession>
    <name>A0A232EKZ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003670">
        <property type="protein sequence ID" value="OXU19029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKZ0"/>
    <dbReference type="OrthoDB" id="8192785at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031734">
        <property type="entry name" value="MBF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37685">
        <property type="entry name" value="GEO11136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37685:SF1">
        <property type="entry name" value="GEO11136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15868">
        <property type="entry name" value="MBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="200" mass="22257" checksum="4A37EB202A37FDE6" modified="2017-10-25" version="1" fragment="single">LPLGGSKTWVAPPNHMPTKGYGPITNYQKIAFIVPQGDRALKMQDFDLSTVKYLTSHRKTHASLQTMLIGASRGSTDQHEHWRTAQVIRYVGICSVLQQLLYAFTIECNTDSVMDYGNAINNNNKLQEKRARTSLKEKRTFSTDGTAKITLIKALDQKTNGNGAYVSLINGGPGQTFVTLEFKSQKGHGINFVVELYAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKZ3</accession>
    <name>A0A232EKZ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003697">
        <property type="protein sequence ID" value="OXU18991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKZ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12390" checksum="D3B5E6874397E8EA" modified="2017-10-25" version="1">MAARLHRTGRPCVYSKEEPKLTGLTRCNSERQLRDFLHLGHHTESLKVRKQFKFSYGNLTQGKLWKTSHDSTLPTQCMKVQSNMCIARIEVSEESCNLRVGELKMVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENT2</accession>
    <name>A0A232ENT2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_001737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003096">
        <property type="protein sequence ID" value="OXU19987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENT2"/>
    <dbReference type="OrthoDB" id="430300at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF39">
        <property type="entry name" value="GH23453P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51743" checksum="665488265A3F1C94" modified="2017-10-25" version="1">MDPPISSWRRLTFIEPVTFFIMFSFSISDSVITDMIVFKTCRKIMQGDERNNCTILYENSSSDAAKALQEIVQPHTATLLVLKSSIETLFPTIIILFLGPWSDTNGRKPLVTFPFIGSIIYYSLFAIQSSFEIDTYWFLIPCLISSLMGGFPTILLTCFCYITDVTDSQNRSWRLGFLDFVLFGGQLVGYLVSPVLFKEFGYCVVFAVSAVSCAIGFAYSYFFLRETIYTGLGRSVKSIFKLTLIKDLFVTATKKRSGFDRGIFLCCLLMIAFHDDMMQGTATIVYLFTKRFGWSIMDFSTYSVVQLSVNMIGMMLLIKIIAPYLKLPETVSIIIASLSNNGNALAKAFARQSWHMYLATGIGIFSLAPASLVRSIISKTIAKHDVGKAFAITTTMEKIGPFITTPLFVLLHTNFIKTYPCPVWFLPAVLTWVNIILAIIVHYRWRRLRIKRSTRETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENU0</accession>
    <name>A0A232ENU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_010449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003071">
        <property type="protein sequence ID" value="OXU20024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENU0"/>
    <dbReference type="STRING" id="543379.A0A232ENU0"/>
    <dbReference type="OrthoDB" id="10259804at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="421"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU20024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="587" mass="66273" checksum="067614DC249F99F6" modified="2017-10-25" version="1">MDSRDRHGPNDKVTITLRETETFFLFDLPQLTEDAGTEAGRAVIEENERYRRIMSGAGRKTVDAETQTAQLYTKTRGTYVGREERKNKATFVNNWVMHDAYRDEEKIGAGEPDERDRFKFPRDKPSELHHLQPEDQLAAIAATDAYVDATRVTLRILASKRYEEAQKRFAGLLRQDPCDPALELVYALEPLWRHENERTRRRTVSAFRWNPANGSLLAVGYGAVAKSSSPDEPSPADGLVLLWCAKNPSEPDRCYEFGSPVSDLDWSKSRPNLLAVGFYDGLVRVVDVSKKQLAVVRQSQRESSPSYEPHWQVQWWPMFDDRLDPREQLYTSNQDGRISFYPAKEAFASRQIFKLQRIQGRIPGVRRVNHCLGHDIPISRSPGALLLRRHPDQPDIYLVGTEEGCVLRCSTAQPQQHLDSFLAHDGPIYSLEFSPFCGKLLLSCGADWTTRIWAEGLDEPLLCFGTRMASVSAAAWSPRNSTIFASAVGNEICIWDIRRKTHRPASVTRVCEDTNARLRCLEFTRTGEQIVAADDEGVVYVIGLTGMPLPPFDQTQTLVEALRKALLTKPEILARLAKIGQPFGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP55</accession>
    <name>A0A232EP55_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_013988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003012">
        <property type="protein sequence ID" value="OXU20121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP55"/>
    <dbReference type="STRING" id="543379.A0A232EP55"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="15457" checksum="ACF06345B75898E5" modified="2017-10-25" version="1">MSLFMLHRLLRAPRKIIPVEYCLQVNNYAIPGMSLGKGKKLGKGKGTTVEKKLLPVETDANKLVTYCCGTNLLKEGGEDVKLKPDEEYPDWLWTIRTGPAPKLEELDPNTKEYWKRLRREGIKRNNKLKSLRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPJ9</accession>
    <name>A0A232EPJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001777</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002918">
        <property type="protein sequence ID" value="OXU20309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPJ9"/>
    <dbReference type="STRING" id="543379.A0A232EPJ9"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000005">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF131">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="11">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU20309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1138" mass="131281" checksum="F1F3A093C866ED86" modified="2017-10-25" version="1">MAKRFQPPLYMRKCNSSLFVAGEAYCGLWLPPVHMLHVDKDTSAKMSKKSSEFVAVFTRRNHQGNPEESQETLLSESGDNQSMVTWTDTSIKAYFKHILPYASPIFLIIKWIGYLVMFILTTYVLLQCTQYFKEAKIQQEHIYEELNSFHVNAEEKLKELNDLQETMEDKLENINILTEQGSKRIKDMFTFSKTDLLKDYEEDNGEQCDFIPLNLRFDCHPENGASELSCRNRGCCWNVLHQLHYEKLVPLDVPYCYYPKNWSLYKYQNFSKDGNDFSGLLSLERDSFYKKDLKLVKIEATGIDDTTLRVKIFDPMNKRYEPPFPARSDPRPFMKKTSNPLYELKMDENVPGFKVMRSSDKRTLFNSIGFGGFIFSDQFLQISSVLPSHNIYGLGEHRTNLRLNTNWQKLTLFNSDQPPTENANLYGSHPFYMVVEKTGKAHGVLFLNSNAMDIILQPTPAITFRSIGGIFDIYFFAGPTPADVLKQYSEIVGKPFLPPYWSLGFHLCKYGYGTLEKTKAVWQRTRDALIPFDTQWNDLDYMDNNNDFTYDKTKFKDLPNFIQEIHDAGMHYIPLIDAGVSANEKNGTYIPYDEGVKRGIFIFDGESNEPFKGKVWNTVSTTWPDFTNPETTSYYTEMMSNMHKDFEYDGAWIDMNEPSNFYNGHINGCKATSLDNPPYLPNVNGNLLARKTVCMNAKQHFGNHYDLHNVYGTSQAVVVNHALKQIRNKRPFIISRSTWEGHGFYAGHWTGDVYSAWHDLRMSIPEILAYSLFQIPMVGADICGFDGNTTVALCNRWMQLGAFYPFSRNHNSDDTIDQDPVAMGQLVVESSKKALRIRYRLLPYLYTLFYRAHRYGETVARPLFIEFNEDPMTFNIDTQFLWGSCLMITPVLEEGKTEVHVYIPRGLWYNYHTMEFSFTIGKNYTLDAPMDTIPLLVRGGCIIPVQEPSVTTTLSRQKPFGLLIALDEHESAKGELYWDDGDSLDSIEKKEYNLFEFEVSNNVLTSTVIECSFDDKMKLGTITVMGISKVVKQVFFNDKDVEFEYDKEKSVLYVNNILVDFTRKFELRWSYKKIEDPLTTTALPIQKYSTSHPADVDASHNEGQYMNSAPTYSSSITYASLLNLIIIKYFMSIYCAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPR7</accession>
    <name>A0A232EPR7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002890">
        <property type="protein sequence ID" value="OXU20379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPR7"/>
    <dbReference type="STRING" id="543379.A0A232EPR7"/>
    <dbReference type="OrthoDB" id="10249691at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039231">
        <property type="entry name" value="TPGS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31854:SF2">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="232" mass="26131" checksum="2A3BCBC6701A3C96" modified="2017-10-25" version="1">MSFFVDMVSEDSFYENLTLGVSRLLEANPCVKNVQLERRGACDRAALSTWEQKHCCLLTEDLRNFYTSTDGFLLTWSLEISGEEFPIGRMEIKDLSSLKRHVGSVTSGKDQQAENSGSSSSSATTSTADEVKALTSLVEPTFGGSRCKLFELAECADCRVFLAYQLQPDQDEPSVWLHSSTTQRWYQLADSFSKYFRMMLVHLGLPLWQMCAAGLQLPTWLEQKEIPNEHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ64</accession>
    <name>A0A232EQ64_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_005556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002809">
        <property type="protein sequence ID" value="OXU20529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ64"/>
    <dbReference type="STRING" id="543379.A0A232EQ64"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF216">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013234841" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="620" mass="68729" checksum="15F1ECDDBE5F0E14" modified="2017-10-25" version="1">MDQHLVMFFTAILVLIYATNFGRCGLDDTADEEDAGTYDFVIIGAGSGGSVLANRLSEVANWKILLVEAGKEEMFLTDIPLLAPILHITDYNWGYRTEPKSGKLGYCLSMTDGRCNWPRGKALGGTSVINFMIYTRGARADYDEWEAMGNPGWAYRDVLPYFLKSENSRLKYQDQRYHSLGGYLDVSNVPYVSRLRQPFLQSAKEFGYKFNDYNGESLMGFSPVQANLRFGRRVSASKAFLDPIVNRRKNLRISTFSRVTKILVNSETRRASAVKFIGINNNKTYVARARREVLLCAGTLNSPQLLMLSGIGPKAHLESFGIKVLEDLPVGQNLQDHVSMSALTFLVNDSVTIIEPRLVMNPINTFDYLLKGSGPFTVPGGAEALAFIDTKSLLENRKPGKGPSSANYPDIELVLGIGALTGDVSGSLRSLFGFSDDFERRVFSHYKGLDAFSIVPILMRPKSRGRVSLRSANPMEPPILEANYYERSEDLDTIVRGIKAAIKVASSRAFKRFNATLLPVAFPGCEHLQFASDDYWACVARHVSTTLGHFTSTCRMAPRAQGGVVDSRLRVYGIQGLRVVDASVMPEIIAGHTCAPTYMIGEKAADMIKQDWAVLKSNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQK0</accession>
    <name>A0A232EQK0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002769">
        <property type="protein sequence ID" value="OXU20602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQK0"/>
    <dbReference type="STRING" id="543379.A0A232EQK0"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="2">
        <location>
            <begin position="97"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="36082" checksum="29A66836A4F28A69" modified="2017-10-25" version="1">MFKFTKKAKKKLKMAESRVKFDEDSSNGLFIEEKYIPEEILSLILCYVDHKTLLACQLVCKQWQFIMQDFVWHKKAELSLGRVIPKNKSVPWQLYYFSCTKPFEKNLIKNHSGELGLNAHWTVTASGGNGWKVEAPPHGVPPLPDDPVFEDKVHCFVTSFYVNPSSRHAQNVDILSCHKFQIVDLIKEGFTEYLLDNFQPKIKVSEWIASRWDCSATYGCDFQLIGVKNKKKVRVFDFKRMIKELTAENNTQNEWIKVEYTFEGYGKGLRKIKFMHGGQDRRFWRGHYGSKMAGACVKVENPIFDVDNDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQY2</accession>
    <name>A0A232EQY2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase delta small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002698">
        <property type="protein sequence ID" value="OXU20751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQY2"/>
    <dbReference type="STRING" id="543379.A0A232EQY2"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="27"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="184"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU20751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50555" checksum="389CAA623CA61D08" modified="2017-10-25" version="1">MEQIERKSAEFEDFGRFQIESRSFSKQFSGIYKARLSSLKAKVLKRARAKWSKHKVLHIVDLTKDEYEEVPSIIIGTLYKHQELKPSILKEMAEELQAVPQPSRLNYCSTKDSLYLEDDVSRVKLVGNLTAEALVTGLICAVCGHQTKDGSFWVAVEDVCYPGPYLRPLNQTPSSCAKDHDKFILLLSGLDFVNEADSIPMDLLREWITGSLGEEFVQEEAAKIVRVIIAGNSVRGLPKTFTRKGYFENKRKEALVNLEMHHSVHRLDKFISKIAGSCSVTLMPGEFDPSCHSLPQHSLHPNILPISSRGKNLYGTTNPWIGKIGSRIVGGSSGQPIDDIMKVSNVDLSPLDWLEKTLEWQHFAPTAPDTLAEYPFDQADPLVMNEIPNIYFVGNMKRYETKLVQGIDRNDDSEGQPVRLICIPKFSTSQTAVLVDLDSLDTKPVSFGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER85</accession>
    <name>A0A232ER85_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002649">
        <property type="protein sequence ID" value="OXU20868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER85"/>
    <dbReference type="STRING" id="543379.A0A232ER85"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="327" mass="37533" checksum="E614F8B7942073D0" modified="2017-10-25" version="1">MKTENSQVQCSFCKWYPLFSKNALEAVTLPMPEEVCKYLEHDAFLLPVEATSSGIPSNSEWSDGSAVNHDESDQESEEQPTFPDFSRQIQEVIDDFGAVFVKSNWSTPSDATWVAATKTLKCNSLEDVYLLLKSSDRISHDLSSIKNSNNKDSPLTPCLVLKKWRDIDPCTEFRCFVVNKELIGICQRDSSQYYRHIENEKYDIQRDIKSLFMEKIKDKFSVDNYSFDVIRYKKDKVKIVDFGLLNESVTKGTLFTLEELQSEVPEAPEFRFIAEDMGIQPKTTRHFCIPQEVNEFFQATGGMSVIDAIRNEVEEQGRLSNDDEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERH0</accession>
    <name>A0A232ERH0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002600">
        <property type="protein sequence ID" value="OXU20960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERH0"/>
    <dbReference type="OrthoDB" id="9986793at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="142" mass="16628" checksum="953D0F83B759123D" modified="2017-10-25" version="1" fragment="single">SEVLFKKNVQTKVVSGKRGHLLVILDLTVEVLRARRGPLARQRRRREYNKDDAHVVTILGVIHLDPHVSSRQVEREVGTIVTIDYENPHWHRTVDHQHRRSLMVWCGIVNGYLIGPYFFEQNVDRNSYLQLITDQLPEVAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERL2</accession>
    <name>A0A232ERL2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002594">
        <property type="protein sequence ID" value="OXU20971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERL2"/>
    <dbReference type="STRING" id="543379.A0A232ERL2"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="55"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="397" mass="44038" checksum="375BA47CFC63EED2" modified="2017-10-25" version="1" fragment="single">PCGVDYELKAFVGETQDDKPHKRNSVRLAIRKIMYAPSKQGEQPSTEVSKDFMMSPSKLHLEASLDKELYHHGENIAVNVHIANNSNRTVKKIKVSVRQFADICLFSTAQYKCTVAEAESDIGVAPGFTLSKVFSLKPTLADNKDKRGLALDGQLKHEDTNLASSTMEGCPVGPGFTLSKVFSLTPLLANNKDKWGLALDGQLKHEDTNLASSTLEFLPVPFVQLRALNHGSYKKDLKLYYVPPDVKNHQKMLTSAYLCNLAMKSMKYVCSNCLRTLSFFSKHITARANSFHLQCMTKVADPSQRENLGIIVQYKVKVKLCLGALAGELVAELPFILMHPKPEEEEPAPSTARPSPTHKTEDGAEDTNLIQLDEEADGDDIIFEDFARLRLKGETDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESM3</accession>
    <name>A0A232ESM3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002397">
        <property type="protein sequence ID" value="OXU21358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESM3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11071" checksum="38E466DE3A32082B" modified="2017-10-25" version="1">MDKARGKICPILALLLLVFGGLRYIGFEVFFIHAGGNNTHRKILDYEVPTQAVLNGCCNDTLVKIHYTKRLRVETLGQHYKVYVTKTSENSKCNIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EST5</accession>
    <name>A0A232EST5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_013864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002377">
        <property type="protein sequence ID" value="OXU21420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EST5"/>
    <dbReference type="STRING" id="543379.A0A232EST5"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU21420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="156" mass="17485" checksum="8E377E214D92C4FD" modified="2017-10-25" version="1">MPMWTGSSDSQVRSNAGSVSGGADDDQARLRLKRKLQRNRTSFSNEQIDALEKEFERTHYPDVFARERLAGKIGLPEARIQRRDNPQQQQQQQQQQQQQQQQQQQQHGVSLGHPTPPPSSGILGGQPPQAPSPPRIHHGFAPSVYPGIPSMSDSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETC4</accession>
    <name>A0A232ETC4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002294">
        <property type="protein sequence ID" value="OXU21601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETC4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6949" checksum="05363286D5BD73CD" modified="2017-10-25" version="1">MTETKIVGFRGGSRMLTLDLTSKASSRSFEGQSDMLCLYFKGNFNRYRYIFDVEDPQLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU18</accession>
    <name>A0A232EU18_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MCM10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_012468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002185">
        <property type="protein sequence ID" value="OXU21855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU18"/>
    <dbReference type="STRING" id="543379.A0A232EU18"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor Mcm10 C-terminal" evidence="10">
        <location>
            <begin position="377"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="731" mass="82335" checksum="B25E28051828653D" modified="2017-10-25" version="1">MSHEDSDDDLLADLLANADDDDGPKPSASSSTESPSKPRALKELDFNFLDEDFSSNFEDETPKVPSPRSQKEAASAIDDHANSSDDEDKKYFEKQQYSDYGRDIKNLLKTKETEKKDKSLEYTFRKENTDNNSLTRNESLSKTNNSPLSNSFNKLAPKNDKYSLQVPASPSSTLARKDVYSDPIFGLKIVKPLVSSAELTEKMQGRKAVTVSNIKLHLTNQALGLLPEDWVIAGVLLNTSTKTSQKGSHYCIWKISDLSTDMKAVSIFLFSGAYKQFWKTGPGAVVGILNPSVMESRDDKDLATLSVDNALKIMILGTSRDLGRCKSMKKSGDPCTAPVNLSQCEYCIYHIKQEYGKYSRRSELQTTGMRRAFGNTSSSPKTATQQRHPEAANFVAIPAKRNEAQYKKDCERLALLRGDSSAIKKFKQQQQQKEPEKKVKATSVELTTCQMRKDQERLTKLQQWSATQNFDSPTVKEEKKPEPKFSLPVPKLGTGVKGGIIDFSQPIPKNLDRARLSAIEWVRKNGSFKKTNPNKIRPAKEELAEKGIKRRREEEEGEEIEAEKIRKEEVVKSKFQEMLEMKSAHSDLIEKRQDEETEQYFRKLEAKERMEEKMLTTYKIDCKAVRCSVCKYVAFSSSDLCKKLQHPIKVIDAVKRFFKCGDCGNRTISLDRIPTETCKKCSSSKWVKAAMMSEKKTELAGSKLCIRGGEEKFIGSMATDASLNLLVPESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV48</accession>
    <name>A0A232EV48_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Beta-4-GalNAcT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004249</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01002053">
        <property type="protein sequence ID" value="OXU22230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV48"/>
    <dbReference type="STRING" id="543379.A0A232EV48"/>
    <dbReference type="OrthoDB" id="10038994at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033842">
        <property type="term" value="F:N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF57">
        <property type="entry name" value="BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="319"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU22230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="440" mass="48831" checksum="A61150E9A1EF1C17" modified="2017-10-25" version="1">MTVAAAVAAPWHRAHIYKALACIVFVLIALQYLLSGAIDRRSIETIFTINTSRPPHQRALVIYGPATASSNNNINNNNNEDEDDSSSGAGPPPGNSSLVSTSSAVIAPTNNSSILLNSMLRTNSSGSPLDVEAVIRLRNATSSTVGLSTSTSPTATQTPRCPLVPPNLVGPIAVSKSPPDLAAMEKAFAKVKQGGRGAPEDCVARYRVAIVIPFRDRFPHLMTLLYNLHPLLLRQQLDYQIFVIEQEGNGQFNRAMLMNIGYVEALKERPFDCFIFHDVDLLPENDRNLYTCPEQPRHMSVAVDKFLYRQVFFSLFAASAALPYSDLFGGVSAMTTEHFRLVNGFSNVFWGWGAEDDDMANRIKARGLHISRYPANIARYKMLTHKKEKANPKRYEFLKTGKKRFLTDGLSNLQYEILVKKKPKLYTWFLARLTPPAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVE9</accession>
    <name>A0A232EVE9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002008">
        <property type="protein sequence ID" value="OXU22320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVE9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="71" mass="8487" checksum="70A8AF7CEB2FF34F" modified="2017-10-25" version="1">MNFSWENYVGFCTNTADLKENYFITMNFHRDACKIYISILTSTVPLHVLVNRFCRFLCKVQALQILNQYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVG3</accession>
    <name>A0A232EVG3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01002005">
        <property type="protein sequence ID" value="OXU22334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVG3"/>
    <dbReference type="STRING" id="543379.A0A232EVG3"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF59">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="312" mass="34361" checksum="98934B6DDCBE3441" modified="2017-10-25" version="1">MPYKVKPDTGLIDYNKLAEDAKLFKPKIIIAGVSCYSRCLDYKKFREIADENNAYLFSDMAHISGLVAAGVIASPFEYSDVVSTTTHKTLRGPRAGVIFFRKGIKNIAKNGEKIMYDLENKINQAVFPGLQGGPHNHAIAGIATSMKQVTTPEFVTYQKQVIANAKRLCSQLQEFGYKISTGGTDVHMLLVDLRPVSLTGSKAEKILEEISIACNKNTVPGDRSAFNPSGIRLGTPALTTRGLKENDIDKVAAFIHKGLILAKEITIKSGPKLVDFKNTLENDDHFRKQISALKAEVEKFAQSFPIPGHENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVS6</accession>
    <name>A0A232EVS6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Interference hedgehog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_005968</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc).</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer. Heterotetramer; 2 iHog chains bind 2 hh chains when facilitated by heparin, heparin is required to promote high-affinity interactions between hh and iHog.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the immunoglobulin superfamily. IHOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001949">
        <property type="protein sequence ID" value="OXU22478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVS6"/>
    <dbReference type="STRING" id="543379.A0A232EVS6"/>
    <dbReference type="OrthoDB" id="9998697at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF33">
        <property type="entry name" value="BROTHER OF IHOG, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="118"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="225"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="313"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="447"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="558"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="405"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="703"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU22478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="831" mass="91062" checksum="91E3BEE3F27DF023" modified="2017-10-25" version="1">MRPASTLCGIAAVLLCALGCCASAGQKSEPGMVFTRHPQPLDAPLCDEVYFECSLNLAAERFVWRHRPLGSSEWILLDSGSAGGGKTSRYVVSFNDTNKAGDYRCIAFYGTSGLASDPARLTQARIERFSDKSDVHLRVRAGNNVPITCPVPYSLPEADIQFFKDDKPIQNASLTGSKIMIIERARATDSGYYRCQAYNYITSEQYTSNHRTLLTVDENTTDQPPYSIKQPQHEYKVQRGKNVTLECFAVGYPVPQVTWTKLGSSLPSTSSYSPMGLNLVNVQPSDRGEYDCVWANRAGHVKSVIILTVVEPPKIVQAPKLSIYPEGGELELSCNATGYPAPRIEWLINGETLSTGKNLQIKGSTLYISLVEKKHAGIVQCVASNEYGSHSGYNYLRVTPKQHLGGNKSRNDFGMSSNGHKHTRVGGRRRGKNGKRKDSGMLDVMVPPNQPNVTRLSDVSVMVRWSVPENHGLPISFFKVQYRELGQKPNSKQAKWMTHNTEIPSHVRSFEVPDLQPDHTYRFRIAAVYSNNDNAVSPISVRFHLSRMAGFESNTMPIPLLTHTEALSPNEVLLIWQNTNRSADIDGFYVYHRASTSAGDYIKTTVEGKNSTNITISHLQPDTTYEFKVQSFSVDAASEFSQILRQKTRKVVTEAPIPQVLAESKVNPVESARSSNMYAIIGGVLGGAILLAALAGIGVAYKRSKHKQSRESSQDQGKPITNGRVMNGGITDSKINITSNPLAGLESTEDPMQPKSGQQSSMEMASFLNGQNNNGSSNSNNSHQPTAPILQQNHIGNHQDSPSGAALPAQTDTTSPPPPLLQAVLPIEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWB3</accession>
    <name>A0A232EWB3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001903">
        <property type="protein sequence ID" value="OXU22606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWB3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="32" mass="3556" checksum="D33136E7773801E2" modified="2017-10-25" version="1">MAVARRQSVCLASQRILVQARGPSLFRCTLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY42</accession>
    <name>A0A232EY42_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_010887</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001679">
        <property type="protein sequence ID" value="OXU23243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY42"/>
    <dbReference type="STRING" id="543379.A0A232EY42"/>
    <dbReference type="OrthoDB" id="5920068at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="12">
        <location>
            <begin position="407"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="537"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU23243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="68671" checksum="D183FA4894B9583F" modified="2017-10-25" version="1">MSGESEVNAASARPPYNSSFPSSKMNAVETTTSTLLADSAFLRLLITLGNFLKCVARIGFVLVNNMYCIPTYVIWMMLLSPVKVYYPQIYWRIEGLFFHWLLAMVSMWTWSAGYDVIEQGDDINRIISDRTLVIANHQSTGDVPILMTTFNAKPNALPNLMWIMDRVFKFTNFGIVSLLHKDFFISSGRKRREESLRQLEKHLKEAYIPLERKWMVLFPEGGFLCKRRETSQKYAKKNNLPILENVSLPRVGALQTIFDVVGPVQNNNSSEQQLNSRTNMAVTKPEIRWILDITIAYPQGKPLDLPTIITGSRPPCETVLFYRLFPTSMVPKEPEQLSRWLYDRWAEKEALLENFYKHGTFVGTQPLEPEDSKIQQDPLRFLVLHLFFMTSSYIHYNRMVKLYALTILYKGPTSATALKTAYDVDSFSYFQRGSVREFMAFVSKTITERTQIAARQSVKEGEYMCHVYVRGDSLAGVLISDHEYPNRVSHTLITRVLDEFAAKYPAHTWPTLREATTDFQQVNVYLAKYQNPREADALTKMQEDLDETKIILHNTLEAVLQRGEKLDDLVQKSEGLSIQSKAFYKTARKTNSCCSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYY5</accession>
    <name>A0A232EYY5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001564">
        <property type="protein sequence ID" value="OXU23581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYY5"/>
    <dbReference type="STRING" id="543379.A0A232EYY5"/>
    <dbReference type="OrthoDB" id="6413693at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="90"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="192"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="366"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="580" mass="65033" checksum="DFBC7FB2A5434C49" modified="2017-10-25" version="1" fragment="single">MVYQRFAIEPMDQTAVIGSKVTLPCRVLNQKGPIQWTKDDFGLGRQRNLTGFDRYAMIGSDEEGDFSLRIYPVELEDDGVYHVLVPPEKPKILQGDYLMTTEDRKITLECVSIAGKPPAEITWIDGLGIVLHDGIETQQSQYQDGPLYNVKSILTVTPRKEHHNTTFTCQSQNAADRTPQIAKLRVEVRYAPKVSLKILHRQQNEQIREGSELRFKCRAEGNPPKMDYKWYINDKMAVGDYTTEMIIHNVTRDYHDAIVKCEVYNDVGKSEETKTLEVTYGPQFRHPPVSVQSHYGASETLQCDVDGNPQPEIYWTHEESDRILATTPNITLTVRPESAGRYYCHARVPGFPELTGSANIYIRAAPTIISQRTQYVPDEGLIKVQCIAISVPKADSVVWSFAGRDLNFSSNNTPFYRHEEYEPERVVSTVTLLDPVSAYFGDYNCTVTNAYGTDSAVIKLTTHVDWQLILIVVGLVVCVILIGIIVILILHCRERIKQPQPKAAQAHENDMQETDSNADRYRESDRSSNLSDVKADIRAGSSVSNAESARSLLHVQAPLSAHYITGGPNGGVATVKRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYY7</accession>
    <name>A0A232EYY7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase PRP4 homolog</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">TSAR_005960</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">Alberta</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with CLK1 C-terminus. Associates with the U5 snRNP and NCOR1 deacetylase complexes. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001586">
        <property type="protein sequence ID" value="OXU23519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYY7"/>
    <dbReference type="STRING" id="543379.A0A232EYY7"/>
    <dbReference type="OrthoDB" id="3967at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000123">
        <property type="entry name" value="serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="660"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="206"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="514"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="247"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="370"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="449"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OXU23519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="979" mass="114487" checksum="408CEFC98726B0B6" modified="2017-10-25" version="1">MQLELSSNSRVRTEKSHVVQTRLFISVPSSSTKSTYKDFREMSELKRYVFCRSSDLECDDKKDPGEISDSDVPMEQRSSSKKKKRKHKHHKHKKDKLADKLDGKSDKDRKKHKKHKKSKKSKSEENGNGAVIDKIVTQIVYEKEINGKLNNSVLEIGETEESEEEKMVDLDSDEVDCTIIEDDIDLEELMKQKERLQACLVQYLSDDSEKDERNGGKNKQGLPDVIVVEDSGDEDQPLKKRRISASESRDHRKVLKSDRRVVVDMSRGERRNRDEPDRRRDLERKRDEKTRSSRDELKRDDRLSSRNDRKVYEKTKEDMRKEELLRKKLEDDRRKEALKKEESRRREHEKSKEEERKRDAERSSASAVRSSHDSKSKDLRPSRRDSSRDRHLNHDPRSRDRRDSRDRHRERSRDRLDTRRNHDRRDRSRSGRRSRSLGRSRRSRSRNRRDRDRHGRETDRERKTGDKFKDSLSEGLKIDNLESSSESEIDIDIKEDEDEEAIIERRRKQREELLKRLGAPNEDSNFSSDVNATRSPPSERQEYLSNKMHSNSNNNNESNSESHTPPLPERRRRSKGDEKSGTDKQDDKNNDKKEDKANSKKSNEWDMFAEVDNVGDFNSPTVDGVKRQGGPDNNPSLTDNWDDAEGYYRVRVGETLDSRYLVYGYTGQGVFSNVVRARDTVRGNMDVAVKIIRNNEIMHRTGLKELEILRKLNDADADDRFHCLRLYRHFFHKNHLCMVFESLSMNLREVLKKYGKDVGLHVKAVRSYTQQLFLALKLLKRANILHADIKPDNILVSESKLVLKLCDFGSASFAHENEITPYLVSRFYRAPEIILGIPYDFGIDMWSVGCTIYELYTGKIMFSGKTNNQMLKFFMDLKGKMPNKLIRKGQFKDRHFDTNCNFLYHEVDRVTEREKVVQMSTLPATRDLGAELGGHGLPAEQARKVAQLKDLLERTLMLDAGKRITVNHALAHPFIQEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ21</accession>
    <name>A0A232EZ21_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001535">
        <property type="protein sequence ID" value="OXU23664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ21"/>
    <dbReference type="STRING" id="543379.A0A232EZ21"/>
    <dbReference type="OrthoDB" id="6077228at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF11">
        <property type="entry name" value="SERRANO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="100"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="483" mass="52674" checksum="3682CAF7F1AA2148" modified="2017-10-25" version="1">MAATDGQIIVAAARWADEATYLRDFVGKYRLPAVIKITKGHTALLVSAGRRRKIVAQAVKIKEGRRVVGVGPRLAIPDSYVGYFEILSEEGRAVRGIESRARFSALAREDNISGVHTARALLSKRLPLTVRLVHGQPPRGLKSSSQFLPELRLLSSFEEEHARSGGFLRRSASSDSANAPSHHRHSHSAHHHHYHHQHSVPGHGYGRDENRVPPASYTEEYDEIDQIYDYVRGFAPLPKSVRSPYETPAPLGNGLNLGSSNQQSNGLGSPALTPVTVTIAPLLDDRPEPPPIETIPTKKNQAEKRTRRAVKETLPPTTTTTTTTSMAHHRVEKPPLAKLYVKNSGTQRGRPLMRQKSASPLKETPPGFKGGSPLFNIRYKSLTNLQQAMELDGTLDSSHSGGRTSGDSGAGAKLPEKRSRRLSRPRSLTNLVWELRNGSGIGGGCVRPETPPTQTVAPLPPTKCGPRLAVTVVAPRRVGTLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ41</accession>
    <name>A0A232EZ41_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_005366</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001512">
        <property type="protein sequence ID" value="OXU23746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ41"/>
    <dbReference type="STRING" id="543379.A0A232EZ41"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU23746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56672" checksum="ABA0F0D926C5C1DF" modified="2017-10-25" version="1">MDFWLCVTLIAVLTYLVFKAHKKRHYFAKYGIPQPPEIPFIGAVGASILTGYHVNYAMKDVYNTNRDAKYVGIHAFIYPIIVLRDIDLIKNVIVKNFDHFSDHKTLVSEKSDPLFGKNLANLKGERWREVRNLLSPVFSSSKMRTMHELMSRCAENFANRFLESNSSKEAVDMKDAFTRYTNDVIASCAFGIEVDSLKEPNNEFYLHGKTSTDFTKPSVFVSFLLNMVCPSLANKLGLRIVSQEETDYFVKLIKETIKAREERGIKRPDMLQLLLDSQEKTKKLDFLDLTAQAFIFFAAGFDTVSTHACCMAHELAVNPDVQRKLQAEIDEVMRNCKGRPTYEAVNNMPYLDAIFRETMRIHPIAFITRICTKEFELPPTLPGAEPYVLKPGMEVQVPTVGIHHDPDYYDDPEKFDPERFMDKKASSDILNLGFGLGPRMCIGNRFAILETKVLFVHLLAKCDLVPCEKTCNPMVYADRSFIPAAKGGFWLKAVPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ68</accession>
    <name>A0A232EZ68_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001546">
        <property type="protein sequence ID" value="OXU23633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ68"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8302" checksum="AED7E65C3BE5812A" modified="2017-10-25" version="1" fragment="single">MTRELEEKKIGGKLLCRTNLSSAALGKTKETYIKKKRTHNRSPFTEKSMPYWDDCVYRIASQLHCADDVPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZE9</accession>
    <name>A0A232EZE9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001584">
        <property type="protein sequence ID" value="OXU23528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZE9"/>
    <dbReference type="OrthoDB" id="10006435at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF71">
        <property type="entry name" value="NOSE RESISTANT-TO-FLUOXETINE PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="217"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="655" mass="75042" checksum="73BCFA42E251EF8D" modified="2017-10-25" version="1">MYVFDASAKYPYGIIDGQTRHLGSFDQCYRIDAQVRGADGFENVKGRYCLVDYKYQQRDATADFKGKLNFEFDPNESVWEAIREKGDFRRIRRYMLQMALCVPAACSAEDVQRALQGPFESYAAKNNLLVKVSVDPNNCQAYHEEPEFSTGAFVYCCVLFSIFALVVVASLYDGTLSTEEEKLGTSRGRQLLLCFSAKRNLHTIFEVSYKHRGLDTIHLLRFVSTCFVVAAHRMMQYYLNTVVNERNLEITIIKMIVMRLPYFQTYDVPSFVMVHNGPIIVDGFFAIGGLLACYGLLDQFDKTKRVNFLGLTLIRFLRFTPAYALLIFFNVYLFQHMGSGPQWKSKIGVEADNCAATWWAHLFYLNNYMTMDRICIFQSWYLAVDFHCYLIGIALIYAFWKYPRRVGYSILGAATFVSILIPFYLTYVYRIQPLFIGFPYLNDLQIDPYFVNYYVKSHLRMTAYLVGVISGAILYDYQKASWRISKRLSQGLFVLLVVLLGIYSQSLGYQYYNPNSNPSSLEMALYASLHRGTFAASYCAIILLITMGDGLDLHYNFLTPGWAQPLGRLTYSVFLSHNILQSYDVGSARSARTFSICNTFWDSIPDVVCSFSLALLIAIGIEGPFRKLEKYFIVKRSKNIPIPATNSNKETDKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZK8</accession>
    <name>A0A232EZK8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001524">
        <property type="protein sequence ID" value="OXU23700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZK8"/>
    <dbReference type="STRING" id="543379.A0A232EZK8"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028:SF2">
        <property type="entry name" value="CYTH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="SI:CH211-156B7.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="177" mass="20036" checksum="110CFC80D84AFAE3" modified="2017-10-25" version="1">MKNVEIKAKVDNIDHVEEKAKKLSDTPLVVIDQHDIFFHVPSSQAARGGRLKLRQFKDGTGELIYYERPDVTGPKTSTYSMVKLDEERRRNLRVVLTQSNGVLGTIEKTRNLYMVGQTRIHIDRVLGLGNFLELEVVLNDSDDPRIGEEIAKNLMKDLGISENSLLSGAYMDMVLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZN0</accession>
    <name>A0A232EZN0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001461">
        <property type="protein sequence ID" value="OXU23894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZN0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="9644" checksum="2A45C9964C0D1A84" modified="2017-10-25" version="1">MPTQVNPTQKVFQSCLVFAVLVESAPRGAAEDSSLSESVRATIKENDLTCENYGAFCQNAAVEATPMPSERVVIVNACRVQVNKELHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0P1</accession>
    <name>A0A232F0P1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001411">
        <property type="protein sequence ID" value="OXU24067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0P1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="10332" checksum="0DB624C158DE9DD7" modified="2017-10-25" version="1">MKLPLESEQEKVDGEIPRARNWHHHGDDIDFINCYACAEPLLQIQPVINCPSYLDKYMNVRLEVDDNIINRRRIRLRAQDHHIERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F140</accession>
    <name>A0A232F140_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001382">
        <property type="protein sequence ID" value="OXU24167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F140"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9183" checksum="7B162B94E10239C3" modified="2017-10-25" version="1">MTQGKAMAGGWMQQSREPVPEFPPLHGDSADSDSDRENNSKPRALAKEKESIAYGLVTITYASLPLNDLRAPLAYYSFLGSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F185</accession>
    <name>A0A232F185_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_001594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001339">
        <property type="protein sequence ID" value="OXU24310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F185"/>
    <dbReference type="STRING" id="543379.A0A232F185"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14564" checksum="F91C4D1098103333" modified="2017-10-25" version="1">MSFHWGFGETILFEGWKTTDVGGIVGSMVGVILLGMIYEALKNYREYLNVSNAVHNPKETLSRNEAMFSVIHVVQTLLQGIQIIVGYFLMFIFMTYNTYLCIAVVAGSMLGYFLFSWKNSKCDISECCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1A6</accession>
    <name>A0A232F1A6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001286">
        <property type="protein sequence ID" value="OXU24485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1A6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="244" mass="27791" checksum="F416D944A528C785" modified="2017-10-25" version="1">MSSCRGKSISIGFTNQMRAAYYSTCKISGRCASYVMGRLGFNLVRAKEKGGDCESTSAFAGENDEEEDILHTGKYVRHHQEPVNKLYLLFLVSTTVVACFCVFVVIPQLVDYFTVSKVLNIENSICAPQKQSVIELLDTERTRRNQERLEIMHKVNALQRNYKLLQIEYRKAQEMFLKKLHNAYKYEKSVDSKLQSPHQAQPAASSSEQAEMEIFELDNTTANIHEDESERPPAEKITHSIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1V3</accession>
    <name>A0A232F1V3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with TCOF1 in an RNA-independent manner. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL or FBLL1 assemble stepwise onto the snoRNA. Interacts with NOP1 and NOP58. Interacts with NUFIP1, RUVBL1 and RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP56 with NUFIP1. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with NOP2 and FBL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001214">
        <property type="protein sequence ID" value="OXU24705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1V3"/>
    <dbReference type="STRING" id="543379.A0A232F1V3"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="315"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="519" mass="57848" checksum="A7537DB025204353" modified="2017-10-25" version="1">MVSRYFRSANFVGAQIHCLHCQSKLFVLYEHAAGYALFSVKEFEEVGMLLPQVEASVTDLSRFNQVVKLVGFSPFKTALTALENINSISEGVVPEDLQLFLDTNIPKASKKEKVVLGIGDPKLGASITEALNIKCDHTGAVPEIIRGIRYHFHNLVKGFTAKSSGVAQLGLGHSYSRAKVKFNVNRVDNMIIQSIALLDQLDKDVNTFSMRIREWYSYHFPELVKIVPDNYMYAKVARLIKNRKELNQEKLEELEEIVMDSGKAQAIIDASKSSMGMDISPIDLLNIEMFASRVIALADYRKELAEYLRSKMAGVAPNLATLIGDQVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLLFHSTFIGRAGAKNKGRISRYLANKCSIASRIDCFAETPCNVFGEKLRQQVEDRLKFYETGEVPKKNIEVMQEAIDEASTIDADVEEESPKKKKKDKKRKSELTNGDLNGTVENGQNGNKMEVDGEEEEAPKKKKKKKKSKNVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F298</accession>
    <name>A0A232F298_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_015669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001156">
        <property type="protein sequence ID" value="OXU24946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F298"/>
    <dbReference type="STRING" id="543379.A0A232F298"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="890"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1166"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1168"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU24946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1266" mass="142015" checksum="0A6CBE06FAB71A17" modified="2017-10-25" version="1">MENAARKQFDLVDGLVFAGMLGVSAVVGVYQAYKSRKNPNAVKEYLVGGQKMSIFPISMSLIASYISGIAILGLPAEMYVYGTQLWCIVIADCFVSLTMAIVYLPVFYGLQITSSYEYLELRFNHVVRLIGSFIFLMKMLLYIPLVIYVPALAFNQVTGVNLHMIASIVCAVCIFYTTLVSLSCMPKRIRCLAGKCTQGGLKAVVWTDAIQTIVMFGGVIVVAVLGTARAGGWSEVWRRNLETGRVEFFNMDPNPTVRHTFWTVVVGNYLNWLATCSVNQAMVQRCLAMPNLRKSNITIAIMAVGIVAIVSLSCYTGIVIFAAFHDCDPVSTKQIRKPDQLLPFFVMEMARTIPGLPGLFVSGVFSAALSTMSTGLNSMSGVIYEDMIKPCLKKPMSDVAASRVMKLTVVVIGVVCVALVLLVEKLSGLIQAGKSLSGITAGPLLGIFTLGMFFPFANSMGAIAGALVSLNLVAWISFGTQAAVATGKIHFPVKPVSVDGCPDALKFSAANLSLVIESAAEETPFFLYRMSYLWYTWVGFLTAIIVGLLVSWITGPNKYKAADYKLYTPIIRGLLRGKDIKPKSNVEDEERFGTRRKPWNYPDLTTNFHHSQNRTCCSPADEIEAMWQGNDDEDSNSMHSVEVQTEKSALYLWKQDRKNDNSLKKSSQEMLDNKKIHSMDNANSKNQAQESDHLKLKKTRLNYEHDKIKAKLKSNISSPEAFDEYAETDLDQPMDYTLCYNEPNLDDDKKRNASYLHSKNDFLCVEETVEEEKVGVIKPKGAFSKELTKNKREMFSNTSRSFKEIFNFFKDRDKKRSTTESTKSSVENQKLPKAMETCEQKFLKCSQPVQPPLEQCEKESKLKNETPCSQQTPLMFSRCSSLGSLNGFEQHSVQDERSSVVSDFSRRTSGVVSPSELPDSPAQTAAPGTKLQLKPQIGCFGKKKMPSPHQDKSKNASLASDNALQNENILRMIPFAKRSVFEDNLTSFKDESTPTKLHSMAASSLSSLTIDDEDEYDIVNKIILNKEKSNVIDETKIESVRENPLGRADLDDTSVKPEKTENSVNDDDDEEENFDDEKDDELTDLTPYEEQLLDECIRRGIAKWTKQNINEIKPFSWDVGLTCLATRAILNSRIRVNSYSDIDDTDNLTNHDIIETLTNNNLNFEKNSQNKEKESDNYEKCSNRDTSPTEQEMDLEEASDKFDENSYYITYEEHLLDQCIRRGMAKITKRNVNDIKPFSWDANQICLTTRAMILRERLDEEMYSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2G2</accession>
    <name>A0A232F2G2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001172">
        <property type="protein sequence ID" value="OXU24885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2G2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="12023" checksum="E00C4C1936588DEE" modified="2017-10-25" version="1">MQPYRYTLEEHGDLKYKAMAVRGHELEIRQKLAKERPDLSIKKRQEYARMLANYAGLNRYGTFKPLEPYVHPEEPDKNRKKRSENDSKNQSHSMFFHKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2L1</accession>
    <name>A0A232F2L1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001185">
        <property type="protein sequence ID" value="OXU24822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2L1"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="171" mass="19168" checksum="DB1462FF29038A09" modified="2017-10-25" version="1">MNCVYTVVEEIALLGFQYSFFHTTIMKVAIVACVLTICSIFAGSKADLTEDQRKILQPLKDECFEETGLDAVTLEKFKKEALQKFKATGEVSNDEKVNCFSACMFKKIGFMSEEGKFEEDTVRALMSENFPPETLDKAIENCKNEVGKDHCETASKLIVCFINNKAGMENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3M9</accession>
    <name>A0A232F3M9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_012484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001122">
        <property type="protein sequence ID" value="OXU25053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3M9"/>
    <dbReference type="STRING" id="543379.A0A232F3M9"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025593">
        <property type="entry name" value="GAS8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040709">
        <property type="entry name" value="Importin_rep_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13851">
        <property type="entry name" value="GAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18773">
        <property type="entry name" value="Importin_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1188" mass="135407" checksum="25EEEF6D398C2878" modified="2017-10-25" version="1">MDHATAVENAVKRFYASGDNDTHAWLLQAQASPEAWTFVWQLLDPSKPGEVQFFAATTLHAKISKQWEEVPNSEYLGLQVRVLEVLKHPGTSKIVLTRLCQALAAFMANSSMSQLENSEKCMVEELIEILPYNSSATVGLFLRVLEAIPREFDRRQGVKQLKQRESILNNWCKAAWILQQIFSSCTQTNDNNSDALFLSGIECTLSWLKLGQLPLDTIGQIYPHLLLAAARYIPNRDNEEDDNARGWEVVQECLTMVVTHTELYKRPQLFWEWAKSFICMVKEHSAKYYYEILTTFGEAHSRTFLLALANIGPNTEGQKWTVEQIKWTKDQQKLIAEQLIEFLLECSEQEGRYPVDEKRSCVPFGFWYALQDDLNTLDVAHEQQAILALKPIYSRLARALLEKTTLPASPSEAGTPDELELLRCYRQDAADTLIYCYNVIGHDLLILLGQRLSQSHDDVSKWTEVESTIHAFKALSDNINRKDFHYLTAIMDLMLSHIPYGMYPREVLCCACSAVGAYAEWIGECPEPWLERSLQLVVLGLTHGPITSPAASMALKDIVRECSAHLAPLAPSILETIGRTLPNVTPGGGEGLRLMYAAGELLKSLRTTEEQMSHLESTLGLCVMRLRELLQLPVNEARVAVSNQLKMISMFFTTLEGAICSPVLEALLPIFEGIVNHPDWSRDDSTLDAMYNCAQKSVSSLFYPEREAVSLLHLLDTSYKIRPHPAALVFLKQLVLVGGRNPAISDELIRVFGEISGLTLGGIASCRQANGNLSDLSDLLEAYLLLLAQVCKKNARLLLQIPDQVPEMLRCEQLEVYSAKLLEEMEREREERNFFQIERDNIQTFWDITRQQLHESRTTNRVLRKEQQDFAKKSEEETLQSRKKLTHLVHTYQNEAANINIDHLVALKKFQNQFVQKKTEIITNNNNNLKIENEVNLANLNQSHALKLEHRKVVENMKNEFKQDCIEIQNKYDDKIMAYHKQFSLKHNIEMMEVEERKNEHASKLIKEHAEAFGELKSFYNNILLNNLSVIDNLKKKFSQVKKNEMKMMGQLKDLKIENRIACLLLPETATVKAAGCFLTNAIRQSPHMQTFIQPIGQELVCVILQCVGGVVPRNSLEPHAEVLLVLNKACPEWTAQWLRLALADRSAPVVPQPQKESFIQAVLRERTNKRRLCDKLKARIKYMLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3X2</accession>
    <name>A0A232F3X2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001113">
        <property type="protein sequence ID" value="OXU25097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3X2"/>
    <dbReference type="STRING" id="543379.A0A232F3X2"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="138"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="545" mass="62196" checksum="F68B42E12FD4FE76" modified="2017-10-25" version="1">MYNIALVDNRRRRRESDAEILNFDDIVWLEAHIRKSSIVTAEEACTYLECSQSPLYSYYTMARFEKSLTRVVGLVTAEATRFGAGNRNFAVACCALISKKEHGEKGRSCIRKMSTSIEDPYLRHLFDADPTFNVYNKNVVNLSVGAPGPDLLQQCSSLLAKATKHRLEEEEKEGKFYLFQYGITAGLWECREELAKFLTRRYGDPVQRENLILTCGATHGLQLILTSVMAPNGVIFVDEVTYMIALDAFKQFPMKRVVSVPMKDDVVDLDAFEKIVKEEKRKSYTIGNDKIFWAMYYTVPTFHNPTGMSLSPEMSRRLVKMARENWFAVVCDDVYNLLHYKAEYPPHRLFNYDDPKDPDYYGGNVISNGSFSKILSPAIRVGWIECGPRVANILKDSGILKSGGAVNHYVSGLIASILQLKLEDEYLDNLIRTYRERMKALCNVLDNHLPSNCSYRHPEGGYFVWIKLPEDFDALPFMKWCQEVHKVMAIPGARFSNHGKSKNYIRVSISFHSAETIAEATKVLCNAITEYTRTKLLQIKIQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F462</accession>
    <name>A0A232F462_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001038">
        <property type="protein sequence ID" value="OXU25392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F462"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895589" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="118" mass="12626" checksum="339A40B4C2C29B2E" modified="2017-10-25" version="1">MKSVLVVFAAICIAGVLSDTKGDIDACVAESKVDTKLFEHMMHTPNFKATREMDCFAACMFKKDGVLDADGNVDASKLPNVDVSKVCGALRGKDACETAGKIMGCFAEKGVMDVFHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4V0</accession>
    <name>A0A232F4V0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001009">
        <property type="protein sequence ID" value="OXU25500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4V0"/>
    <dbReference type="STRING" id="543379.A0A232F4V0"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56645" checksum="01E1AEFDFEB089CC" modified="2017-10-25" version="1" fragment="single">CAYDKRHNRFLGLVCFFSAENIAMQRISKLYLSLANRTVASSLAEMPDCRGLPVIGTISSLVQSDRGKRLHEYIDKMHRRHGPMFRGRIGPTKAIFVSSTDAIREVFRLEGPTPQHFVPEAWLLYNKLKDRERGLLFMDGQEWLHYRRILNKMMLAPDSAKSMSKPCQEAAMDLVEKWKGYRNNERIVPDLENQLYQWSIEVLLATLVGSAWPSYRRSILNELGILSCSLSRIFEYSVHLSSVPARLAMLLRMPSWTGFVTAADYSLDTVGRFVEEMEKLENAEDGLLGAMLRNGIDSEMLKRICVDLILAAGDTTAYSMQWLLYLMASNPSAQEAARQSLLELDEAEVLRNAFLKGAIKESLRLYPTAPFLTRILPQDTLLAGYPACKGELVVVSLYSCGRDEANFPRADEFLPQRWLRSEKGEFQGVINPNATLPFAMGARSCIGRKLAEVQMSLTMAELLRNFKIDCVNKNKVRMKLRMISAPSEPLQLQLTPWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5R1</accession>
    <name>A0A232F5R1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000869">
        <property type="protein sequence ID" value="OXU26131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F5R1"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="737"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1684" mass="191383" checksum="7A24ECF6EDB161B9" modified="2017-10-25" version="1">MQQNTHTRSLQSAASKCYTLYKKKIQQLQVSPPSNNVPPPRYNFHPFLHGFSRLSSGAVRYTTTSYTLSTQLFYINPRTRTAAAASQQHTTYLLFRSSSPRRLFILKSSYRPYWCVVSFALGDFRSKKRNFSIMTDSLKFGPEWLRNLAGDGCNSGGGGASLTTPRYQLAEHRYGREEMLALFDRNYKPPEPLISFAGLYVPKTQLPLALIQMTEEETRLWNGGVSVSTGRGRGGSVDRGGRSRSGRTYRGAGFDDLGDSPRNESQPFPARTRAFDRPPADRSWSERNGAVDSVEWNGSTSPRKELSRGASGGSLMESNWRRHRGGGDDEDGWRMNSRENRGLGKGSWRDADKDRADGDDDKRGERWDHKGGNRAFDPHPPPLRRNRSNHHDNHDNLPEWATENPSESGGSFDASGAFHGMYSDDDEDHPGDKSQQERKRGSRVRRVSEGNAPHSKNGVKSSPASGGNIRSTKAERSLNGERPKSLHSSESKDQYTSAEKESRRSLSPISSPPVPSSPAPKKTQATTNNAGSGGGSKTSASVAESKKKEKASKQEKQQKEQAQTNASKAKSKVESPKKVAESKAKAETQSSTFSEIPDEADPEQASNMIEMAKREQEIYRRLQEVFQMKQDLQQQSPQQQKQLQHQSSQSVPASADSSIIEGPTEDKQRSTEADHLDRMEEEVAKLIDSAGLGDEKPPMSVPPPVLPKSAATSSVVVNQGVIDPAVATVMQSTTIVQEKWYYRDPQGEVQGPFLASEMAEWHKQGYFAPNLLVRRTCDERYTTLGDLVNLCGTVPFKPGANFPPLKLTDTILPSMASTLPTGLPVTSALPKPANQLDPLMLYQIEQYRMVQNQHMFLKQLRASAINKLSQSEQWSSLTPVEQNQLVLQYVRSIDPELADLTPLQPSVIPSTFIPTIPPPAPPSNSVLQLFPQLHQTAKTQAEAQHVPAQNSHPVNTQSMQSSPIDPIQQLMQQMSGIRNLPPMPQAPIAPSPPQPQPQPQSQLQDDNPIKQWMRQFSVQAQQQRPQPQPQPPVESVWQQPVLNPNTFNRVQDWVSQVRGVHPMQPAVIPGRKSLLDFYKEKMMTEQQILKEQREMVEEEQRKLKELEMQRMQQARAKQEAEVEQQRKQDELRMKQERAKRQQEEELARLKAEEAAKREEAERKKREEEKKRKEEEKRRQEEEQRKQEEKRRKEEERKREEKRKQDEEANKKKQEEEKRKREELKRQEEKLRKEEEKRKKLEEEQRKQEEERLRKEEEARKKAEAEEQARKAEQRRREAEALRKLQERSKAPWAQAPPAPPTTAQASLAEIQRLEKEKKAEVLRLQQLLQQRQLAQQKAAEAAQEALADSAKRLQFKWAEKSAPVNNVNRVQSLAQIQQEEQERIAKLKQQEKERQEKEKASHKETPVTLQNVSIWGAASQSLTWSSTSNSGNQMYGSGGGGGFWDDPAPKVNAPVPKASTPKVPQKQQPNMVKSPAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQQQQQLQQQQNNKVAKSKNKKDEELVKKLFEQNTAKTDDFTQWCSKTLIGLEVSVDIPTFIGFLRDIEAAYEVKEYVRMYLGDSKQCSEFAKQFLEKRSKWRSSQRPQTQADDLCKPAPAINPNTSTEFQEVKSKSKKPKKGKMFKVDSKMLGFSVMSAPDRINVGDRDYADSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6N4</accession>
    <name>A0A232F6N4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="10">Glu-AdT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_004022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="function">
        <text evidence="10">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-tRNA(Asn) + L-glutamine + ATP + H2O = L-asparaginyl-tRNA(Asn) + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01000786">
        <property type="protein sequence ID" value="OXU26514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6N4"/>
    <dbReference type="STRING" id="543379.A0A232F6N4"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.410:FF:000001">
        <property type="entry name" value="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="entry name" value="GatB domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004014">
        <property type="entry name" value="PRK05477.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="11">
        <location>
            <begin position="384"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="535" mass="61301" checksum="0F250E9589B00400" modified="2017-10-25" version="1">MKSFAIPRFPVNDSRLKQNYSFLKRFFCNKAKEKPKSKEKWNAVVGLEIHAQIASKSKLFSGASTEYGKAANTCVAFFDCATPGTLPVLNRRCVEAGVLTALALSCKVNEISLFDRKHYFYADLPAGYQITQQRQPLAIDGELKFRVFTPGVHKEPYLKSSKLKQIQLEQDSGKSIHDELSKVSLIDLNRAGVPLMEFVFEPDLSDGEEAAALVKELMLILERLNTCSCRMDEGALRVDANVSINKPDEALGIRTEVKNIGSVRAVAAAVNYEIKRQIKARESGIKITIETRAWDSVNNKTVSMRDKEEKQATKLRFFKMQPNLPPLHIHVHEKFENKYNLVDAPSLQKQIPEMPEETREKLATKFSVHKALILVLVNEPKLLELFTYIIKDEKRTPNLVAKTLVNQLLHFLYKNDLDFNYCTNIRDHLCELMDLLESGTINLLVFHSVLGEVLKNPKDFPRQIVERNDWIQITDEAELRKICRDTLNEYPKEVELYKKGKHKLFRFFMNCIKKSTNEKANLGHVEKILQKMLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F784</accession>
    <name>A0A232F784_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000826">
        <property type="protein sequence ID" value="OXU26309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F784"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="11091" checksum="9520B16469D6DBD6" modified="2017-10-25" version="1">MSLDVFGRKLEGSQVSRGPPGNGFNFTPDVHRGINNGGLYFLLSGTLGVPILTRLRRSQRWLPGTDRKSITRGNSANAAQQKPGVAVISAEPSCLLLVTAPGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7F1</accession>
    <name>A0A232F7F1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000811">
        <property type="protein sequence ID" value="OXU26378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7F1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7523" checksum="36217D0C9A4DD21C" modified="2017-10-25" version="1">MNNLRLYDIKLLQAWGSVGPPNDVSLAKSYNRKQFEANKENKDLDLPDICKGYRIIQSNTPPKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7G2</accession>
    <name>A0A232F7G2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000722">
        <property type="protein sequence ID" value="OXU26794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7G2"/>
    <dbReference type="STRING" id="543379.A0A232F7G2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="14"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="189"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39898" checksum="0E181114A959EF5C" modified="2017-10-25" version="1">MAAIWGEISALNPTYTFKWVIRDFHVDGYKLGEAIKSSVFAVTSINDKYHWQLLLYPKGNIENHKEFCSIGFLNRQCSKAFRGSITFGLVDGKGNVVRRIEIVDRIFSPNKLNGNPRFFPRRLIANVLRDGNLAIVCTVRMGATSRAKKDEVEVTDERMDVDEKVDDESALRLREFDDFEHLLDEKAFSDVIFIVGGNTLYAHKCILSTRSPVFAAMFLHEMLEKQENKVEVKDVDYDVFREMMRFMYTGKVNRLDSTMAYDLLIAADKYALDTLKNMTEKKLCDGLTDSSALEYLQLADRYRAKKLKERAVDFIIQHADVIIKSVEFKALPNELVIEICGAMANRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F861</accession>
    <name>A0A232F861_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_010843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000754">
        <property type="protein sequence ID" value="OXU26658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F861"/>
    <dbReference type="STRING" id="543379.A0A232F861"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18345">
        <property type="entry name" value="BTB_POZ_roadkill-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="8">
        <location>
            <begin position="90"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48532" checksum="7EAAF56E95D30F58" modified="2017-10-25" version="1">MCLVAYNTISVKASYANLKTQSTPPVGFSHNRMALARLSVSDCAPQTSRVSSNLHSSSSMAVSRVPSPPPPEVNTPVAENWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSAGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTIFCEVSVVADSVNISGQSNTIQFKVPECRLPDDLGLLFENQKFSDVTLSVCGKEFEAHKAILAARSPVFSAMFEHEMEERKQNRVDITDVDQDVFREMLRFIYTGKSPNLEKMADDLLAAADKYALERLKVMCEEALCTSLAIDNAADILILADLHSADQLKAQAIDFINTHATDVMETPGFKSMVTSHPNLIAEAFRALATQQVPPIGPPRKRVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F890</accession>
    <name>A0A232F890_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000785">
        <property type="protein sequence ID" value="OXU26517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F890"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012601818" evidence="1">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="229" mass="24815" checksum="C815DB550F32F2B3" modified="2017-10-25" version="1">MSRKLWILIFLVCSAGLIVCAHGAGSEEKNGTEMSSSNSSGDSGGGSIVNAIMSDISKFTDKLMDMIKDIVDGAKSLVMEILEMIFMSDDKSMTTTRRRRSVDSSEGSLPGNTSIMGMISNVFLAPFKMAFGLVKDLSPSSIIHGLENVLSPIEDVIHTAPVQAFTNTTKKLFDSATSELWNFTKSNVLPELNKAVTTLRKSDALPSTLNNYLGDLQDLYMICRTLGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F944</accession>
    <name>A0A232F944_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000686">
        <property type="protein sequence ID" value="OXU26979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F944"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="358" mass="40257" checksum="2DC56A827E7FB9D1" modified="2017-10-25" version="1">MGTINSSIDSDHGPAGTSIREKVVDDLDDTVEMDLANLKTPEDDDRRLCFSPSMRKTTDEEQNIGLDAASEIFDKSTDEDYEEFDPIDYFNVKSGPTDKSNELLMAEEEFHEASVNFDLDLLPTTDQETAVQDVLINKRSTFFILFSIDECTTEDNTTFGIVSACKNKVDDDESNQEIRLELSAEQQGNSQTSDVGTAGCKNDEEGNSNYGIMDYTDESDQEVEKNQSLAKQEAVQDNEKLNQDNDITNNGDPMDISRDDDDTYQQDEATKKEPSKKKLQVIPIKDKVYNTRRRKMRKIKVSPDLGSEISSTSSSSDVEDSSWSDTTTSIDTSEETDCSSDSFSEEPFICTRYNLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAG9</accession>
    <name>A0A232FAG9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000561">
        <property type="protein sequence ID" value="OXU27655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAG9"/>
    <dbReference type="STRING" id="543379.A0A232FAG9"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="423" mass="46465" checksum="F37A162558BBEB6B" modified="2017-10-25" version="1">MRCPHEVVVTCDSSSENWSAATWDPCTGSMLSTYKHASALGHHSLQLLNDSYLIGSNATKPILHLWPLNSQTPVPNLRLSTPGRTTALACTPNGSYIVAAISEKIYVWQTCNGQLINSFARHYQSITCLEFNKDGSCLASGAEDGLIFAWSLSQIASEKEAKPISSFSHHSLPVKDLYFGQVGSFGRLCSVSLDRSARIYDVYAGQLLLTLVFDVPLMSVCMDIMENELFVGSSTGVVIKCNLRDPPRGIEHHVPLNGNDKITVYKGHEGSITALSVSVDCITLLSGSSDGMVHLWDIPSCQIILTLKHKAPIVSAFFATSFENFTANNLKPSLQVKPLQKVSDPGNKNTLIEIIRTNEDDSWILEFDSQVEASTTAASDSSANDYDFKREDALKEIQRLKKVNAEMYQYIAKNILESNETST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAS3</accession>
    <name>A0A232FAS3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000586">
        <property type="protein sequence ID" value="OXU27533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAS3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="213" mass="24003" checksum="96D824929BE042F6" modified="2017-10-25" version="1">MTNKIFEKEVVEMAKKILDKAIEQLERAQRAVTTARENYWQAVEHYRLSDMASTINAVAAEWGTNEQALELQEKQVQTDEGTIQLKTGVPITTKSSIVIKRDTCMQRTESVEAVTRFDLSMHTQEEKLGHHPSPAAHTSIGRYVEVEVSRECDSQPTPQSPPNSPAQTMILNSEQYILRINVESCPKININDYDLPYVVDALNLGGWITSTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBK0</accession>
    <name>A0A232FBK0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000553">
        <property type="protein sequence ID" value="OXU27707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBK0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="316" mass="36906" checksum="D3B653EAF36DDC35" modified="2017-10-25" version="1">MNLESEIFKITCDLYNNLHFSKNSIHFIIDLLRTFIKDIYNHFLLKQLENRVLKVLSADITNHIRSTFEKETGLDLSINNKTYKVYFITNLVLGDNLGQNEILGFVKSFVNTPCCRMCEADGRQIKSLTCEKNELLRNAEKYENYFENLNYRWKGVTEKCIFNNIRDFNVVQNSSVDIMHDVFEGVANKVMAQIILKLVEVKCIKIEYINAKLRTIDFQFENTNVPIDIRLDYVKLYKRLRMSASESLCFTRYFGLIVGNAIVEDHVVWPLYSSLRGIIDIVTSPTITEECFLHLNALIKELNSLYIDLFDKMVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBT4</accession>
    <name>A0A232FBT4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_007587</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000510">
        <property type="protein sequence ID" value="OXU27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBT4"/>
    <dbReference type="STRING" id="543379.A0A232FBT4"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002432">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="62"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="185"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="428"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="570" mass="61799" checksum="5733FC45507BAFAB" modified="2017-10-25" version="1">MALLTVRLAASVARQLPSTQVSWPAAVVASRKYHVSCSRRSAEISSILEERILGASSKTNLEETGRVLSIGDGIARVYGLKNIQADEMVEFSSGLKGMALNLEPDNVGIVVFGNDRHIKEGDIVKRTGAIVDVPVGNELLGRVVDALGNPIDGKGPLNNKLRFRIGTKAPGIIPRESVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTALAIDTIINQKRFNEAGDENKKLYCIYVAVGQKRSTVAQIVKRLTDAGAINYSIIVSATASDAAPLQYLAPYSGCAMGEFFRYDIAEFNDLKSIVDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNKSLGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTKAMKQVAGSMKLELAQYREVAAFAQFGSDLDAATQQLLNRGVRLTELLKQGQYERSISNGFVLSVPMAIEEQVAVIYCGVRGYLDKMDPAKITAFEKEFLAHIKATQQDLLATIAKENIISEASDAKLKKVVTDFLSSFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCH5</accession>
    <name>A0A232FCH5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000420">
        <property type="protein sequence ID" value="OXU28521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCH5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013099287" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14978" checksum="87196F64B15E6BA2" modified="2017-10-25" version="1">MTLLFKWLFLLSLAYSVQIVVFADHFDSAVSDVACFFQARLSSFVERCKFGRLLLDRLSQPTDILSKMDQLSEIELDSKLKDIYEYSGKINYFPLYSNTSIRHENETIRKFYDVLTDLGDSAMRAHLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCI7</accession>
    <name>A0A232FCI7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000470">
        <property type="protein sequence ID" value="OXU28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCI7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624351" description="Single domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9658" checksum="53289722C3414B2F" modified="2017-10-25" version="1">MQNFILILVIFVVSIFAQSEDDMRPEYFNPSSINPTICQLRKCNKENTRTRGDTSKLYPDCCITPICDYFKFQSPTYYRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCL9</accession>
    <name>A0A232FCL9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_006423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000441">
        <property type="protein sequence ID" value="OXU28372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCL9"/>
    <dbReference type="STRING" id="543379.A0A232FCL9"/>
    <dbReference type="OrthoDB" id="10069510at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19708">
        <property type="entry name" value="bHLH_TS_dHLH3B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000015">
        <property type="entry name" value="T-cell acute lymphocytic leukemia 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF15">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="360" mass="38990" checksum="370AE0BD95258EF9" modified="2017-10-25" version="1">MLTYNNASCGTSENENGSPADSLLSGDGEDPGDSPETPRDTEEEATLSDDFYSHDTDDEDDQGRKRCRDRTNSNDGVSSSTNGLLESSPPSRVGGLGVRKLFTNSRERWRQQNVSGAFAELRKLVPTHPPDKKLSKNEILRSAIKYIRLLSRVLEWQKSQDRNGVSTTAHDVRIKTEPQAQQHPPSHHHHSAVTTTIYQAKAAIACLKQENNNYSPRVNLPARISQSYPSESKGRTGQLLMITTPNLKNQTAANNATASSSVYVNGVCPSRLVNGKSTAPAKNGLAVVVGGNNQHVVTSSSSSNAVVVSNGCTPTKRMKTEARDEDEVSQSSGRDCSRAANNAGARKRLKITFGKDSGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCM7</accession>
    <name>A0A232FCM7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_002236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000440">
        <property type="protein sequence ID" value="OXU28382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCM7"/>
    <dbReference type="STRING" id="543379.A0A232FCM7"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="330" mass="36999" checksum="22AAFC8E1D1E93BE" modified="2017-10-25" version="1">MEFPNPTVKNLSNEYKDFPPGCVPCPRGSKPGNPGVFEEIHKKFDNLNPNLFNGMRIIVKKILSNSFNVTHTIALCSQNSVKSANQIGEEKEGYKFASSYTGIKRVGYKERYPILYGDITPSGNLTANLIQTIGCRLRFKFATQVKRNKFKNSKTAIEYRSDDYTITASLVNPHILKQEGLLLLQFLQAITSRVTLGAEIAYEMNSKLPERQQANLALALRYSTGFCTFSSTFGQAGVRLCYHHKQSQQLQMGVEFKSNFRTLESECKIVYQLDLPLADLVCQGFVDTHWRVGAVLEKKLYPLSRASLALSGLIDHNKQNVNVGIGLNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCN2</accession>
    <name>A0A232FCN2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000461">
        <property type="protein sequence ID" value="OXU28218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCN2"/>
    <dbReference type="OrthoDB" id="8190653at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF27">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="522" mass="60868" checksum="7848B426BC7A78DE" modified="2017-10-25" version="1">MAEGAEEMCTRKPTKCLKVPLKSTEQIYLIFLIPAIASCLVYVLHFAADLVVAVQHFREENPVWACITIGFMYAPALAYFILTISRPDWWMTDDDKLYKGAFLWFLLQLIKLIAFPLFALYRYAGLIVLSIDAIMLSGEQRRKTLNVAAAPAAIELYFFLQAWFQAAPQAVFQTHLLFREKGVDRTHQSEVVHMLCILMSICIMAMRTTSFQRYESQRLNGRKVPWAMWLKKYRIQELENLEEKQLLQSTITSSQAETAEATNKPDTDKNSSGQLERQNSMTPPLPPKNVKIIPPPAPLRGITSITPLAVPDMPAPPRPDSLVVDPEDVKLDQIPKSSSDDTTNDRAFERSDSLKIPKRKNFAKGLENDDPVGIFLAFVWWFLFILPRVLSIAIFYEFYPLYLLAVLGVHYVCMIGYLFYYAKYYDVMSFFINLWLGLVYVFSIIEYRIKFKYADKWLIFYYIFVILQNTFMTMFWYFYGNWDGFWYSYSFHMIFICMSLCLLSTIVYYLMLKPKKRRIYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCV1</accession>
    <name>A0A232FCV1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RIB43A-like with coiled-coils protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_003628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIB43A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000465">
        <property type="protein sequence ID" value="OXU28177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCV1"/>
    <dbReference type="STRING" id="543379.A0A232FCV1"/>
    <dbReference type="OrthoDB" id="429119at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008805">
        <property type="entry name" value="RIB43A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14517:SF6">
        <property type="entry name" value="RE41410P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14517">
        <property type="entry name" value="RIB43A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05914">
        <property type="entry name" value="RIB43A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="303"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU28177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="48067" checksum="B76216BA44A37474" modified="2017-10-25" version="1">MLDFQKCTAQDLKAAAAIERKRRIEEERKARIFNPRIRRIGIDKEYLDRQVEEKKRLQDLQREQECRLDEALLRNSQLAIVHEKRLDEERRKLNKELNTFRQTHQKPEFRRDFDLYDPELLKKSKPPGEDGVDPGLASAQKFVPEYLSNHKPVNRRFNPVRRFEGEDENLVARLREQREQMQSWIMQQVQERRLAEREKRDTEQAYQEALLSRDRRALALEHMELECRRRLSEATARFNRALAQEKAERKRCRALQDNEAARAEIYNHVTGDFLTEPKDQAESVHGPKKLLVTRYKGMTSEQLKVIRDEQARQMEEIQRMRAEENEKNEEWNRLMNGNARAAESYQRELDRRRAELNRQIAEENLRLAEQQRSQQDYLNRHVYKNKPGPEFYAQFNKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDS0</accession>
    <name>A0A232FDS0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000360">
        <property type="protein sequence ID" value="OXU28901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDS0"/>
    <dbReference type="OrthoDB" id="77463at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11676">
        <property type="entry name" value="Gemin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009422">
        <property type="entry name" value="Gemin6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046856">
        <property type="entry name" value="Gemin6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046857">
        <property type="entry name" value="Gemin6_Sm-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14710:SF2">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06372">
        <property type="entry name" value="Gemin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20417">
        <property type="entry name" value="Gemin6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="76"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19333" checksum="78254BFCF045A21D" modified="2017-10-25" version="1">MSTHKSDDSSNSLHKIYTNDPILFKSYVNKKVTITTEDSNVHTGIVYTVDPVSESVVLMQPVEGEEKMKMKIIMRPAIQNIECSFDTKVILPEMFVPPPNHFSQEELLRRKNSVMKLLIENRFPITEDKGVLCIEETVRIEPPYGPENCICLNSIVLNRIQTILNRVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE70</accession>
    <name>A0A232FE70_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G protein gamma domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_002362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000352">
        <property type="protein sequence ID" value="OXU28985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE70"/>
    <dbReference type="STRING" id="543379.A0A232FE70"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="9">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="8143" checksum="E512B9520A74CE9B" modified="2017-10-25" version="1">MDMVISNLQQQRQLTEQMRREAAIKRINVSKAVEDLMKFIIDHEQEDCLLVGFSSQKSNPFREKSSCTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG77</accession>
    <name>A0A232FG77_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol kinase 5</fullName>
            <ecNumber evidence="4">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP:glycerol 3-phosphotransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_000850</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000288">
        <property type="protein sequence ID" value="OXU29458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG77"/>
    <dbReference type="STRING" id="543379.A0A232FG77"/>
    <dbReference type="OrthoDB" id="6278781at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07793">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000102">
        <property type="entry name" value="Putative glycerol kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000104">
        <property type="entry name" value="putative glycerol kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037444">
        <property type="entry name" value="GK5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF68">
        <property type="entry name" value="GLYCEROL KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="15">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="16">
        <location>
            <begin position="278"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU29458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="513" mass="57079" checksum="FB722E42F00F686F" modified="2017-10-25" version="1">MRYIAALDVGTTTIRCHILNEAGENVASNSEKVELLYPKPGYVEIDPDWLWDTIIRVIQQCIKESGLEPSKIEALGISTQRSSVITWNTDSGKHYHNFITWKDLRADSMVNSWNSSLTMRGLRLGSKLLYAVSRNKRYQAGSVLRLMNTQMTLRLLWALENVDGLRESADAGKAVFGGVDCWLLYKLTGKRRLSQHITDVSSASATGLYDPFTLKWAGWSQNLFNLPSSMFPRVVDTAGDFGRLPASLFGAEIPITCSMADQSASLLASGCIKPGDLKLTMGTGSFINVNTGDEPHASVSGLYPLVAWRLGTELVYVTEGSSNDTGTIIEWAKFSGIIQDESDTYTLATFVKDSDGVCFVPAFSGLQSPINDQNAAAGFIGIKPTTQKAHLVRAMMESLVFRVVMIYNCLQRETFFSYHKIRVDGGVSQNDFTMQLLSDMTGLEVERSTSSEMSVLGVAFLAGLHQGIWKSKDDILKLRRVEKTFYPNMERKASYAKSFENWKKAVERVKDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGA3</accession>
    <name>A0A232FGA3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000302">
        <property type="protein sequence ID" value="OXU29357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGA3"/>
    <dbReference type="STRING" id="543379.A0A232FGA3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="275" mass="31765" checksum="D66E0B626876DCE3" modified="2017-10-25" version="1">MIFFLYLSSVWADTETKTDILSKPVEDATMVESAKLKRDSWPVQSTPCPPSWPHYQKGWIPEHPKVQLVHHPSYVHKPAVTVVKPHAPSYHNSWHSPDPWQQNVGWNKYGWDKPSYGWPMSSGWQSPGWQSGWKSPSYPSHGWQPKVVAQKPVYSYAPQYHKLAYHVPSYHHPISKPAVIVKPDCPPYQHHNPHHTGIIYAPQHQHHQPQIVKVVKPDYHHPAPVYHHPSPVYHQPAPVYHRPAPVYHHPAPVYNHHSVPSYHPVHVPKVEICDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGC2</accession>
    <name>A0A232FGC2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_004486</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000236">
        <property type="protein sequence ID" value="OXU29811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGC2"/>
    <dbReference type="STRING" id="543379.A0A232FGC2"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 15" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU29811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="334" mass="38721" checksum="D85CB49D7CEB3668" modified="2017-10-25" version="1">MVIFNVAEVTVEYHRGLPRITVPLPSRSEKCMFTLKPITQTVGDFLDILKQEDPAVIDASITSTNGVRMGATNRIETMLLDDFNLIINDKVYPVSPPPPIEKPKENLRQLQDLQCLINQLYETFNAREYHVEMERQVMLQLEEVRIELEPLEQQLMALDEAAVRRSTYASWGVLVFMAMQFGCLARLTWWEYSWDIMEPVTYFVTYATAMGCYIYYLLTRQEYMLPEVFNRERLIGLHKKAKKIGFDLQRYNQLKEESYELEMMLRLIRGPLHMQQCIVEQRRRERLAQCQKSSSSSSSSSSRSPSSSPSPSPDRTVPDDAKKSETTAASKNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGW4</accession>
    <name>A0A232FGW4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STING ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000212">
        <property type="protein sequence ID" value="OXU29991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGW4"/>
    <dbReference type="STRING" id="543379.A0A232FGW4"/>
    <dbReference type="OrthoDB" id="6053839at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061507">
        <property type="term" value="F:2',3'-cyclic GMP-AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12146">
        <property type="entry name" value="STING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12100">
        <property type="entry name" value="Stimulator of interferon genes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029158">
        <property type="entry name" value="STING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033952">
        <property type="entry name" value="STING_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038623">
        <property type="entry name" value="STING_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055432">
        <property type="entry name" value="STING_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339:SF1">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15009">
        <property type="entry name" value="STING_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="STING ligand-binding" evidence="2">
        <location>
            <begin position="160"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="364" mass="41831" checksum="6E94475CAFB564EE" modified="2017-10-25" version="1">MYSEIRSISLGVNIISMFIILILCINQMYEKDVYKAMKETWHLLTLCLMFLIVCVAIFKIRLFFEELFYINSHYNGNFVSVVKATLNFNVPSWVVFAITIVAFMMLVMHSNFNMIQIMQLNPFATLLAIAFSILLFYTINITECRATTVATIFSTGLNPGTAMASSYFYGYLKIILPASGGIERAGILNALETFESKNKVTVPVKKLFILIPSSSYIPPDLKEISNNWLEYVQPLETIAIDRAGVKNRTYHNTIYKFRSNGPNKAGKSYYLATEGATPLKTFLEVQDNSHRYAALYREFNREIIKSFYTTLQNLLNDNPDCKHYCELVYYEDTKGGERTNPAHILRDRIDKYMGDQIIKIKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHA8</accession>
    <name>A0A232FHA8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000191">
        <property type="protein sequence ID" value="OXU30131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHA8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="272" mass="28765" checksum="8BAFB2F04094F0A9" modified="2017-10-25" version="1">MASDSGAYRWWETTKTAVDECAGRDVSGMNGDAESVSSGRRKEQSSSTSSDAAAASAVDATAAATSSGVERISVLSNLRDRVNSLCIVFEIVSGIRLGIKEGKSAENSSVDKRDASRIESQENNPGVPHNRIESNLVSSFFDPGTSSFSTVDSAQPSLNTGELSNDREVRTTTFDESTNRRNDSGLSNLTTDSSADDDEVNPINGNESLTLPTALIGFQIQASSSLGSRIFDVVPILYFQRGNFDSSSSFNAARSTTTTTSEESSFASNSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHB9</accession>
    <name>A0A232FHB9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000190">
        <property type="protein sequence ID" value="OXU30141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHB9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="22" mass="2534" checksum="0BA6FAF5D1B9ABAC" modified="2017-10-25" version="1">MSKADHLALRELQAPQSRHPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI26</accession>
    <name>A0A232FI26_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_012971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000171">
        <property type="protein sequence ID" value="OXU30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FI26"/>
    <dbReference type="OrthoDB" id="298098at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14423">
        <property type="entry name" value="CUE_UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19675">
        <property type="entry name" value="UBR-box_UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000009">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000008">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047503">
        <property type="entry name" value="UBR-box_UBR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024725">
        <property type="entry name" value="UBR5_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46276:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11547">
        <property type="entry name" value="E3_UbLigase_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="10">
        <location>
            <begin position="2520"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="2577"/>
            <end position="2930"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1247"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1505"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1935"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1993"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2059"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2122"/>
            <end position="2153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2165"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2256"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2471"/>
            <end position="2526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1255"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1271"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1506"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1553"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1581"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1610"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1953"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1993"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2066"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2141"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2169"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2179"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2273"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2503"/>
            <end position="2519"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="2899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2930" mass="320166" checksum="ECE0E520799039A5" modified="2017-10-25" version="1">MSSIHFVVHPLPGTDDQLNDRLKEVAEKINRYGFVTPPALNGLKSTIKRIVVGPTHIGLLMDDNRICRVAYTVLYDRLDLRKSEPSRNTTKSHVGNSSSAPSGSSNTGGGSSGAGGSGTGGSGGGSSGSRAGISRSRARIMRNSSAIRGGGSGGSGAGGGSGSAAGNGRIGPPGVIMGGSSSSSSRPIVSVPAPFVPEDLISQAQVVLQGKSRNLIMRELQRTNLDVNLAVNNLLSRDDEEGDDAEDAADSYVPEDLISLLDGGFSNEHSVIIDADSMFPEDVFGYPGMRNRVSSSRRLGNDRDSERSTERDRDRDSFSRWRDRQYYGPRRWLETALKDSWDKDPAQGSYFLFNLDIKKKELASQSPLWISEELEWWNERSEPAPRFVQIAALYSELIAISSTGQLYQWRWSDAEPFKHPDNPNIHHPKTIALNLASEKIVNVSATAIRCSVSTESGKVATWLDELLGHVASRLEHPAQAFTEFTLDKIVSLHTCGLYTVARLESGALYWWGVLPFAQRMKLWEKYKAKSRKHRPSTVASAEITYGSHVCMKNSPIYQAGAIGFTIANGVPKVGQLLSAVWNLDAICRFKILPAGILPPNVATDKRETNGNGSSNSSSKTSHKETADRIDMPPPPSPASSTCSDTGSITTSHKRQKRMAPKSEGDADRKDEEDWHLKDVVFVEDVKTLPIGKVIKVDGCYVAVKFFSKDLKEKEKEAKDKDFNNSDFKDATAEEPTKLLADCRLLRKDELVVMKSSMSSRAPDCFQRTPRRVNIAEGSSENLLTIATDGQGIHAILRSGSKLSYVIYNLSTGRYVQDCYIPSDISSFLGLQPQNISLTSAGENTECSMILRDGNNTIYPIAKDCADAIRDPNWLDLAPVLCVGASTIPIPSIPSMNLKNQVAVIALVFDNLLLMPRILRCDYDGVKQVFANLEQDLKANAAQMQSILNERCDGNRNILHACINMCAPTSNKEVEQGIEHELVTNTVDTNSAPIEEPIPTLSWPPEAFDNTSGEEDSLLGIGSTSISMMNKSASAVNNTYIIDSVERRNNALLILKFMCESPVLGPHLKELLSARDAQGQTPLMLAVSVRAYHAALIVLDTIQRVGKDFKDCSSMILPADASPDLSPLFVTCCNDTCSFTWTGDEHINQDIFECRTCGLTGTLCCCTECARVCHRGHDCKLKHTSPTAYCDCWEKCKCKALIAGRQSARYDLLCRLVTSTDLATKINSRGESILLFLVQTVGRQSVEQRQFRSAPRQRSTSANRKNPSSDRLGADSDMPDHDLEPPRFSRRALERLLNDWSAVQCTIMSGVHESTSEQLFGDQGQSCKQSGTALLDKFTHSLLVKCSAEMLDCLLTTLIRELQNDSIPGRQEEAIVVSRRFVRSVARIFVIFTIEMAPNTTKRRSASQASQPLMKCRRIFQALIKLAVEELCETADSLIAPVRLGVARPTAPFTLTSSAIEVINGSEELFSIEPLIPHSGLVSQSLDTTLTAQTGSNGIAIARDVSAMDDTEPGEEVPMDLDGDISEQEESSAAVSTQPLGEVDGNAGGVGEEPAGDGESDTELDLLVEAETESDSDDNHSNQDAASAQRSVQTGATAGSDGGMNSILLYPEDESGESSQQEDDESEAGETDEQDTEEFQIGDEQLERRSGSTGHSHRNNLAPVSMQWAIRNRESSTRTTGLRVAGGNNLVFIDPSSLRRSTATSTVAAFQEPISMSTTVSCLARAFGIVIRQIADLLTMMQDYKVVAPALPRTLEVTFFDAISLQMYLEEHLKPTWDWLLTVMDATEAQLRFGVSLTRSADPTHPEHPLNSAPSLSGGNFTGLLNSAALSLSLQNNGTGRSARSGITTTSNISTTQGSTRLTVGFTGVGETSRSSRERVDAHSARREFLSYCLSLMRAHNGEHRDSLPVLDVSALRHVAYVFDALVYYMRSLSEPISSRGESQKETTDTTWNDQDENDNEEGDDETLHANASMETDSDYPDLLNIPCASASGSGLLSGGPQSNSSSAAKGRKHPFLQRSDSTLCLGCPPLDPFDTVMSEALPLADQPHLLQPHSRREDLFGVPRQSPGTTASGSGANVLEGLPTRLGLSTRTAEGSLNSSTLILGQIEQIVRNSCSTSAAVDVRNTNAGRSDAGEPGPSKKTYNQTNEQSHPTVAVVEQQTDRAPIIVSPNNQPMETESNSNSSSSPPKSGSSKDVQCKAERSVIVRAGSSSSGSCSSENSINKQSNVVIPEVIVSGVQTDSQTVGANEEVVDLATAPSTSQETSAHETVEGSNSNSSSQSAPSAPDPPQQQHQAPSTPARAQISNIGTKISHNILLGRWRLSLDLFGRVFMEDVGLEAGSIVSELGGFPVKEAKFRRDMEKLRSSQQKDITLSKVERDRTQLLIHTMKELNTQYNLYNRRASNTPPLAVNRVKVTFKDEPGEGSGVARGFYTAIAEALLANEKLPSLEAAQVGSKYTQYNVLQKLKIRERDRDLRRQNPRSSSKCRESRRALSFEARSFHPSTSVEGSSSNSGNSSSTAHPPLFVHANNDHLTMHQQQLGDRLYPKVYALRPTHAEKITGMLLEMNPAQLLMLLASEESLRQKVEEAFELIQSHNQDLASEALLDLDVFSLTERCGATKKKQFEKIIDDQEDNAPLFYAPGKRGFYTPRQGKGSYERLNAFRNVGRLIGLCLLQNELCPIFLNRHVLKYILARPIRFHDLAFFDAVIYESLRQLVVDTEANISNLFQLDLTFSIDLCPEEGGGSIELVPNGRDIEVTAGNIYDYVRKYAEVRMIKVQEKALEAMREGVFDVLPEGALDGLTSEDLRLLLNGVGDINVSVLISYTSFNDESGEPTDRLVKFKRWLWSIVEKMSHVERQDLVYFWTGSPALPASEDGFQPMPSVTIRPADDAHLPTANTCISRLYVPLYSSRHVLRHKLLLAIKTKNFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIK8</accession>
    <name>A0A232FIK8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_015889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01000169">
        <property type="protein sequence ID" value="OXU30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIK8"/>
    <dbReference type="STRING" id="543379.A0A232FIK8"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="285" mass="32074" checksum="82FD6F1564DE8269" modified="2017-10-25" version="1">MSSKGKNKNRLSDRRKRHVVSKEERYRQERDKSDKEESEPEEEWPISFPVAMWDLEHCDPKKCSGRKLARHRLIKTLRLGTRFRGLVLTPVGTKCVSPLDKEIVQDNGCAVVDCSWARLDDTPFNRMRTPHPRLLPFLVAANPINYGKPCQLSCVEAIAATLIITGFPEEANFYLGKFSWGHSFLELNAELLESYAACKSSEEIIAAQDKFLAQARQERLDRLAMPDFPPSESESEEDEEEEGKEGQDGNKESKDEAKKDESSTSKDDTTASGSSSSATAKENDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIP1</accession>
    <name>A0A232FIP1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000188">
        <property type="protein sequence ID" value="OXU30167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIP1"/>
    <dbReference type="STRING" id="543379.A0A232FIP1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="228" mass="26544" checksum="5EFF3275598913B8" modified="2017-10-25" version="1">MFVMKSSKVLQYNYYSYTQKSCRGRSSDDLPLHYFKDVLVYVMKTMTDIYNDSLHSGVVFGCVQNLMRIDVNSLPQIVIDGTPIPFTKSVKDLGVHHVTWNSHILSICSRVHAVLNRLRFRTYYLSSSLKKQLVAALISPHLDYAYNVLCDFSGYLDLKLMRLFNTLVRFIFRLPRDARLSPYIAKLGWLPPDKRRRYFLAVTTYQILKTLKPSYLTPFLPPLSNDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ91</accession>
    <name>A0A232FJ91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000152">
        <property type="protein sequence ID" value="OXU30538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ91"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="39" mass="4439" checksum="5808391A21FD07CC" modified="2017-10-25" version="1">MSYMTLMTVYVTLLRPIVFDLLNDDSATVCSLLNRCVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJE1</accession>
    <name>A0A232FJE1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000118">
        <property type="protein sequence ID" value="OXU30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJE1"/>
    <dbReference type="OrthoDB" id="7543230at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="219" mass="25629" checksum="73D98B27D976005E" modified="2017-10-25" version="1">MDFEVDLTTELTIDLTADQENVTTDSDKPDRITNRVTEEQKNYIIYFVMENPETISHSSTPASEAVLWNDLITHLNSLKPVKSLRNWRRYTLRLINHLKITPDLVLTEEETKFKRFVKKLLETADPESTEEASETDFTEVVIESEEDIRNADKLELEKAKLKLDIIVNDLGVERLNNLILFLKGQNRRCLKKMKRLCASKSYLQMRLREFREARGLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJG5</accession>
    <name>A0A232FJG5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-binding protein NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_002607</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000110">
        <property type="protein sequence ID" value="OXU30886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJG5"/>
    <dbReference type="STRING" id="543379.A0A232FJG5"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000018">
        <property type="entry name" value="RNA-binding protein NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="15">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="14">
        <location>
            <begin position="338"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="103"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU30886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="485" mass="54717" checksum="C8E250FAA268A865" modified="2017-10-25" version="1" fragment="single">MGVESNVEYLIVDTSAFIKNAALQEIGNKIITEPSVVDEIKSKRQLRRLIVLPYDLEVKEAYPEDIKFVTEFAKKTGDYISLSATDIKVIALTYRYEKERVGTDHLRQEPEKKKEIVDSSVHKPDDNNKNLIGFYLPEGEEEDDQVNDNKSETKASNEETKDKPRNVSESSSTSSVDNQHLVTANDISKESESESDYETAQSDEGNSQVDDLSKKFKKLECNPEDLKVECGDDLTIDDILKPMKKDTCEKDDGHDSGSHDEEEEDDNDDDDDDDDEDCSEDDSGWITPKNITNIKKQMDSDVIKEKPATVACLTMDYAMQNVLLQIGLNVASLEGKCIKQMRTFILRCYTCFKTTGVVTKLFCPHCGNKTLKKVAVSVDDEGKQIIHINFRKPLTSRGKKFSLPTFQGGKHACNPILFEDQPIPDQKPSKLGSAKNDPLKEDYIAGYSPFVMRDVNSRAAMLGIKSGSPMKHWMRRNPNEVRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJR6</accession>
    <name>A0A232FJR6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="20">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSAR_012776</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Alberta</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T-cell division asymmetry. Component of the beta-catenin-lit-1 complex which promotes the phosphorylation, down-regulation and subcellular relocation of pop-1. Regulates plp-1 nuclear localization in embryos. Plays a role in male tail tip morphogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="20">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="20"/>
    <dbReference type="EMBL" id="NNAY01000129">
        <property type="protein sequence ID" value="OXU30708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJR6"/>
    <dbReference type="SMR" id="A0A232FJR6"/>
    <dbReference type="STRING" id="543379.A0A232FJR6"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07853">
        <property type="entry name" value="STKc_NLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000162">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000961">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="40"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXU30708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="413" mass="46613" checksum="B38B6F8A836C994B" modified="2017-10-25" version="1">MSLSMSLMQCGGAITGAVGANQAQAALAAAAAHSSAQDAVQPDRPIGYGAFGVVWAVTDPRDGKRVALKKLPNVFQSLVSSKRVFRELKMLCFFKHDNVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSSDHIKVFLYQILRGLKYLHSARILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDKNKHMTQEVVTQYYRAPEILMGARHYTNAVDIWSVGCIFGELLRRRILFQAQSPVQQLELITELLGTPTLEDMKYACEGARSHMLRRTPKPPSLTALYSLSSQATHEAVHLLCQMLVFDPDKRISVTDALAHPYLDEGRLRYHSCMCTCCYTTSAGMRHYTREFEPVTPHTFDDLWERKLTSVQQVKEEMRKFIAEQLNTSRVPLCINPQSAAFKSFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJU4</accession>
    <name>A0A232FJU4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000117">
        <property type="protein sequence ID" value="OXU30810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJU4"/>
    <dbReference type="STRING" id="543379.A0A232FJU4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="439" mass="50107" checksum="D28E4F278E1F30E1" modified="2017-10-25" version="1">MSKFGSPDHDSIWFEDKSLRHPNGAHFDNLRNEIKSWREHVLSSGTYPCFTSWTDSEEDIGSMIEVSDLESEAQDEADDVQNYYTNNKSRMETLWKLYRNIGETIEDMKIRLTQPSLKNKSFTCSEHNNSQNKYIKTESESSDCEKENESTDSTITVEQEPDEILIKSESEKSEYHDNDLSNSNTFDDVLDIQLRESNENIQLSDIHDDIDTQDWPSESSIHRHNSRNSESRVDPTPNCTYDVPRLKQITKEELIFEKKTTSRKKRTAVVDVKKEESAGGSGKKSREPIIVDMYGIRTISYNESPPKVKIPDCFKTSRLSDSSCDEEIELVEEKRHSSILKNRFRNNKRKRSDDNDFLLAYAVNLSGESDAAEASLIKKIRGEENSKDFDRLSEEDLEEQLEIVNNTTSTTTSSSSSSCTCTRSSCSCSASVSSSEVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLU8</accession>
    <name>A0A232FLU8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000041">
        <property type="protein sequence ID" value="OXU31625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLU8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="11597" checksum="226BDDE146CE12F8" modified="2017-10-25" version="1">MSSSVRYQGYGTHIPTNYTIRSGHRDEDHLHEVTLEGQHISSLEELVIVEPEENVYFCASDIGRSNDRRWWMRGLLFWLCQLVLATVCLSILIGIILYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMZ6</accession>
    <name>A0A232FMZ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein detached</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_010010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the dystrophin associated protein complex (DAPC). Interacts with Dg, via the Dg WW domain binding sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000019">
        <property type="protein sequence ID" value="OXU31890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMZ6"/>
    <dbReference type="STRING" id="543379.A0A232FMZ6"/>
    <dbReference type="OrthoDB" id="10057795at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008586">
        <property type="term" value="P:imaginal disc-derived wing vein morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007474">
        <property type="term" value="P:imaginal disc-derived wing vein specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16242">
        <property type="entry name" value="EFh_DMD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02334">
        <property type="entry name" value="ZZ_dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000001">
        <property type="entry name" value="Dystrophin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000004">
        <property type="entry name" value="dystrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="17">
        <location>
            <begin position="441"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="733"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU31890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="789" mass="88289" checksum="6991D4E82D6AE699" modified="2017-10-25" version="1">MELVNGGGIEMLSRRSIVIKDYELEDDEDGSGKEEDADRTSLKIDLSMAEQFYYEVISSFQKEEKLCVFQKSLEELSSRLAGAEALQSGWQPAAANGNPEAAEQLEQLHKFGERLAPIQRLLEEANEQASAFATSSVIVSHALLAKLEDLNSRWKVLQVAVDERYKQLSGFGKDGSTPGSQAFLASSVEPPWERALTPAKVPYYINHQLETTHWDHPKMIDLMSSLADLNEVRFSAYRTAMKLRTVQKRLSLDLLSLSTALEQFDSHGLRAQNDKLIDIPDMVTVLTSIYEHIAAENPTQVSVPLCIDLAINWLLNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLIADPNRLVDQRKLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCFEKAGKDKNEIEAVHFLSWLQQEPQSMVWLPVLHRLAAAESAKHQAKCNICKEYPIVGFRYRCLKCFNFDMCQGCFFSGRKAKNHKLTHPMQEYCTATTSGEDVRDFTRALRNKFKSKRYFKKHPRVGYLPVQTVLEGDALESPAPSPQHSSLSQDMHSRLEIYASRLAEVELSRTRSNSTPDSDDEHQLIAHYCQSLNGGDGVNVPRSPVQVMAAIDAEQREELEAMIRELEEENATLQAEYERLRSKQTPGSTPEDGVHPGRQPDCDMIAEAKLLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLEEPNAASPSKTGTLQTRSVTASQLATDSPAKMNGHYHDSPGGGGGAGEGRVSSLERPPPPPHSHSVTHNVGNLLHMAGSPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNA3</accession>
    <name>A0A232FNA3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNA3"/>
    <dbReference type="STRING" id="543379.A0A232FNA3"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU32142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11484" checksum="8828A8067E311BD3" modified="2017-10-25" version="1">MKNFAAMWMVKQQHRQNQLHSQQQPSGYSYRCEVCGKGYQHRATLLRHTRHECGKEPKFKCPYCPHRTKQRGNLYQHIRTNHPGKTVFSNTVDEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNK3</accession>
    <name>A0A232FNK3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_007847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000008">
        <property type="protein sequence ID" value="OXU32090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNK3"/>
    <dbReference type="STRING" id="543379.A0A232FNK3"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012895605" description="C-type lectin domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="91"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="6">
        <location>
            <begin position="287"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU32090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="412" mass="46017" checksum="F1CF73EE43C8A50D" modified="2017-10-25" version="1">MRLYVFLVLVISIEWPSALSAFQDVSIPSMILDSTEYSFMKFNYCDKSKAVDVTVLQARLEGKISCGCSITEATSVPIKDDYTQTTGVGAHKLHKQATTWNKARKICNEEGGHIAIINSKAEEAVLIKMLVEARNSISGTSNTDEAFVGVHDLYEEGDWVTLDGEPLHSTGFSTWTTNVSIIIMFPKSLLVIVAFVCSVCGESKITVSVTNETQVDLHTYLADLQVAAASAQYSTNLNARLVNMLQELLAQKRVNCNCSGENSKQAYREKAFPLPNYAYVGNSSIGFKLYRERLTWNEARKSCRSEKSALAVPRSFLEYETMVKLLEQPSWEVKWIPAFLGLHHLYGKDDWLTVSGEPVPQWINHKHNLITTERPPVNRVAPDGHCTAIDGNLKLMSIDCNTPFSYICEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNT4</accession>
    <name>A0A232FNT4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNT4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12288" checksum="7B5722D9420814C6" modified="2017-10-25" version="1">MVTASEVHGAQGRQYQRHLLEFYENSQDSGSTSICLAATPMPEPEWQYDTATYDSPAIYDMLYDTYDDLCHVVAAYSLDFLNNDSANIFRKSHGVMLANCVRSKVALDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNZ0</accession>
    <name>A0A232FNZ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000003">
        <property type="protein sequence ID" value="OXU32239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNZ0"/>
    <dbReference type="OrthoDB" id="7698403at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="215" mass="23949" checksum="8FBBCF4432C79935" modified="2017-10-25" version="1">MKEKKITERKKAVLTILTAKIPAHNPLVEVKLSGTRFVNLKSFAKNLNEIKSELKSIFLIPCNCEELNRVSTSICNKVKGNDSAVHSGSSYAGLQKLLACMDVPIISWKTYKKYETKVGQCIESKESCRRSIEEEKKLVLGSTEKILPPDIVEDILPNLQSLHSSSKLASNSLNQNNMTDNNNNEFNVALGDIMNIIVSYDTGWSKKGNCIESIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ED87</accession>
    <name>A0A232ED87_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01007411">
        <property type="protein sequence ID" value="OXU16313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ED87"/>
    <dbReference type="OrthoDB" id="10068277at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12371" checksum="E8146BD3A0F97A48" modified="2017-10-25" version="1">MEHDRKMIVVPETMAERLQNTQHTTVQHQQHAIPTPPTTEGSVQTPGDNLSRLDAEMHEILNSKKFISEEEKSDEKVTGLQDSRRQEDREGLVRKKAWCRVKVKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDC9</accession>
    <name>A0A232EDC9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006779">
        <property type="protein sequence ID" value="OXU16359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDC9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012330628" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="7624" checksum="9F3AE0C8AAC7D49D" modified="2017-10-25" version="1">MEHLPNIAFLLAFVEHGSVALVNKLDAPAGNDSLTPHFVTTRVGNKGYSVSVTGELEFCTVETGAFGICLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEC2</accession>
    <name>A0A232EEC2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005431">
        <property type="protein sequence ID" value="OXU16678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEC2"/>
    <dbReference type="STRING" id="543379.A0A232EEC2"/>
    <dbReference type="OrthoDB" id="8951118at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="173"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU16678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52136" checksum="F3301CA8F598A296" modified="2017-10-25" version="1">MAVQFWGPGVEEVLEIEMHESDTESDDYGYAVEVGKEVGVDGLDPFYSCHGIAGSSIYVDGRYLIVSSLRRMSIFFNCFISPTVVYRRFYSDVACRYFRDVRRKNCYRNMCAEFAKICLAGQSAFSEQRLLCSQEPHFFLNPNVRDEAALVGSPEDLFKRMIVPFRAGAPDLCSLADTRAFFDQCVRDVASDRLASVYWQNTTPASVGITSCFCELHDLHVEDNYLDSANVIRFGEVGSGKVWLLVHPRSFYDLTVALGDSIGRLRILGCDDVSDYLEGCPTPANHKNISITSEYLQARKIPHQFITQRPGDLVYVGPGSYHQVINLGIGVAEAVNVGGPRWNAGADRFITCRCPSNAVGYVPSNPTVTAVVRDRSFRRHVCPTDGCPFIAALLPHIRAHAQVEDDPTGSSKHHACSLCPKIYKQKCHLMRHHQTAHTPGGTPKKACRWCGGLKSASNMSKHERICSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG24</accession>
    <name>A0A232EG24_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004893">
        <property type="protein sequence ID" value="OXU17278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG24"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="21" mass="2425" checksum="AF977C6DB65A5830" modified="2017-10-25" version="1">MPRDGLSTLPRCWTDLARAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG76</accession>
    <name>A0A232EG76_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004839">
        <property type="protein sequence ID" value="OXU17356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG76"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9216" checksum="7428E8098F8761B7" modified="2017-10-25" version="1">MRLKRQATKNEKERDKLTTKRYEKEGAGKTEEQGFKTPRPSIVKSPEEAGTSKSAGKPIGVKGEEGKGAGMIGKALKQRKLKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG89</accession>
    <name>A0A232EG89_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004833">
        <property type="protein sequence ID" value="OXU17363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG89"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="855" mass="99041" checksum="D3D04BDABE101F2D" modified="2017-10-25" version="1">MKSKPVNPVQEVAVPNEEQVNAAQPEAAVPNEEQANAPQPAQLIQEIAEPNQNAAENNQDYISTGLHAYLQKHNTGKEILKAYSLSLQKKIPLKHTIRSKLVRLVIERGKNYALRNITPEDCLDKFVITQQRFEILAKEIAHLFKGENVSTYYTPYVQEGKHIILASGKLWNHFNYTKNCLREAQLLKRRHYDKQQAVLNEDEAALIDENEHVAWLANHLDPWEEVINHWKSSVNVRRKLLLETDITVYDYIQKFNCLQIQAGKELFDIDFKALYPQNRIIYAEQWKKIKTYLISHLDANSNIKCVDDKAFLEVLKSRDLSSEKEDYILLHLLPYIILPKRGGKRKRDDNADQARRLSIEERRESFITAQEVRPKIQDLKARYMRDHRTFQPVIVSVGTVTRINKYYVVINEKVYSSYGSFRKHVLRKHDSLIDETVTADEAFVKNVDSLQDTESINEKIIRIDKQEFNYDSDSDSYDSDDSVIYDFTDFIESDVELNTHNDSLNSIVLKYTANLSNLKKMPRKYVNCIINETKDFLAQFSTLLKEEITSRLNKSSSEISDSLNDIFDNFSNCLAPVDTEQKRFTLFKKLNTYIEPIGFNIGEREEYRKMYDETIQYIESLKSSNIVISNIVQGSFWKERMTHFQNKTVLPLIMYFDEYENNNPLGSHKGLSKSGAVYVVEELNFLSESGIEVQLPSGLKKIYFELALFVGVKAELHAILGLLESFRAKCTLRTVENYQNLLASDDPTVSGIKEKCILHDIKNFHMSNNTCVDVMHDVLEGICRYDLALILNHFIYDAKLFSLEELNLRVRGFDYGFGYHVNKPPELNEDWIKKGCIVITSSEMLCLVQNLNLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGC5</accession>
    <name>A0A232EGC5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004784">
        <property type="protein sequence ID" value="OXU17415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGC5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="41" mass="4575" checksum="C97C3C8C138B1632" modified="2017-10-25" version="1">MLCQGTDLAHSQGVRRIEHAANTNTSKYRRFTLESVVAAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGH0</accession>
    <name>A0A232EGH0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004757">
        <property type="protein sequence ID" value="OXU17459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGH0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7969" checksum="92808D1026B71700" modified="2017-10-25" version="1">MTSIPKELEFEKAVMLRLRHKLYVTLMRNEKTTGNRQRIKDRITENIAMDTLVKTVIKHQQESQISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGN9</accession>
    <name>A0A232EGN9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004705">
        <property type="protein sequence ID" value="OXU17527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGN9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="99" mass="11366" checksum="8D506EFB3E5F4A59" modified="2017-10-25" version="1" fragment="single">DCDITQLSAENRSECTDICVSTPRARERRLQSVRVDPLWRMLIGLPRSLSSKFHNCVNRYRDFAKRHAVPFCIVTYSLAATTYSKVLRRCLLVLVFGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGQ1</accession>
    <name>A0A232EGQ1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004725">
        <property type="protein sequence ID" value="OXU17513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGQ1"/>
    <dbReference type="STRING" id="543379.A0A232EGQ1"/>
    <dbReference type="OrthoDB" id="7255276at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF218">
        <property type="entry name" value="ADULT CUTICLE PROTEIN 65AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="18134" checksum="47215E9D4E0004D2" modified="2017-10-25" version="1">MGNREMLMRGPWVENEYKIARACNCQHIQSSGSPSIQNSSSSNSNQNSNMKTIVVFAALVAVTLAAVPRRRQVSPPGSETIVLKEQLHDNIGLDGYQYSYELSDGSAKQESSQIEVRGNEDATNRVTGSYRWVDELGQEYVITYVADENGFQPQGAHLPTPPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGU7</accession>
    <name>A0A232EGU7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004695">
        <property type="protein sequence ID" value="OXU17542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGU7"/>
    <dbReference type="STRING" id="543379.A0A232EGU7"/>
    <dbReference type="OrthoDB" id="7994850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="488" mass="56066" checksum="7EF5B79DF4D007E5" modified="2017-10-25" version="1">MRFFSSHVTEQPSTPSIKNKPATMDELIARQAKEADLMTRAYLNLTKKSQQSSKGAIQSRMSMLDAKWNSLQERHEQILAIKTAADESKTYFKEEFFDNFDEIYIDQRAKFLDALATLEEQAAPGTETDAHPERKPAVRKLPPISLPQFSGKYSDWSSFKNMFTAFMKHDTDLQDVERLYYLKSCLSGEAADLLKNVSVTDDNYNRAWSRLKDHYENKRALINLCINSLLEIAAVSRESYKALKTLRDATAEAIEMLQTLGRPVEHMDDFLVNLTVRRFDTITRRDWELALGDTKTPTTWKEVDTFLKSRIQALEVSLPQQPALSTAGQTSQKKISTVSTKKSNASGRTVHTIAQRPRRCSYCQGDHSITACNQFRAYDHYNRTWYRLKDHYENKRALINLCINSLLEIAAVSRESYKALKTLRDATAEAIEMLQTLGRPVEHMDDFLVNLTVRRFDTITPRNWELALGDTKTPTTWKEVDTFLKSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHU2</accession>
    <name>A0A232EHU2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004428">
        <property type="protein sequence ID" value="OXU17913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHU2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="199" mass="22350" checksum="C84EADC09DA32A58" modified="2017-10-25" version="1">MYSRASNTSSSTSHSSSSISNNSTTDTAEESVYSQRGEGRGEEENPGFIIESESTRFYRHFSYEEREIRGILPEPFMNADFHSWLEGCVRDLHRQICEKDLWGLLYSAVQSANEFNVNERLSINCAIVKDIVGNGQVRLTEKSVNKKSILTPVVHADIHQVNDDGDAAMINMVKREENEEAEEAEVQQEAVEDSAIEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHW9</accession>
    <name>A0A232EHW9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004415">
        <property type="protein sequence ID" value="OXU17934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHW9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="13119" checksum="86863BF5931FC6C0" modified="2017-10-25" version="1" fragment="single">ASAKIAAESPPSPSPAPNTGIRELCVVVQCRQTITQHPIPNEEFGAKWLERHVTCGLEICRKTSERIEYESILNGTYTAAAEEEKLRHVQQQQHGSMTRRKVPQLHESFLCPREANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI53</accession>
    <name>A0A232EI53_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_004225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004362">
        <property type="protein sequence ID" value="OXU18002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI53"/>
    <dbReference type="STRING" id="543379.A0A232EI53"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="168" mass="18801" checksum="3EE003BA6AFB9C26" modified="2017-10-25" version="1">MRLQSIHLAIEFGDLAIIDALLALHEDVNMRDPTTGHTLVHVAVECDNVEVLKMLLLRKAAINVYSNDSLTPLHLAVRKKSTRMVQFLLDHGANVNPVFNVDDKTPLYMAVELNCPMIVAILLERGASIKHSTIRDVTVFDVARKTNNTYLCLLLLRYADQQLKLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIF2</accession>
    <name>A0A232EIF2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004260">
        <property type="protein sequence ID" value="OXU18133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIF2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="128" mass="14740" checksum="AD0DC2116C50C798" modified="2017-10-25" version="1" fragment="single">WPILTCGYKNIQRAIYFDSLVIEDPWHLDIERDLLPRNDTCMYAQRVPKSTSWAPSSVTLNTQKVFTATVRQLFKTITLNSSRQCKHIYSAQLIKICREAIPNCITHNSSCSQLHGPTTLEKKVEILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJC9</accession>
    <name>A0A232EJC9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_009396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004036">
        <property type="protein sequence ID" value="OXU18467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJC9"/>
    <dbReference type="STRING" id="543379.A0A232EJC9"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF32">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU18467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="170" mass="19529" checksum="8FFE38CABB3D10B0" modified="2017-10-25" version="1">MTRCVACFLSRVSACLFQTMSDKEKKRFHEMAEKDKKRYDTEMQSYIPPKGEKVTGRGKKRKHIKDPNAPKRSLSAFFWFCNDERGKVKMLNPEYGVGDIAKELGKKWSDAGPELKGKYEAMAEKDKARYEREMTAYKKKQKDGPGVCAPAVVAKKAESDEEDGWEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK01</accession>
    <name>A0A232EK01_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA delta isomerase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003898">
        <property type="protein sequence ID" value="OXU18694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK01"/>
    <dbReference type="STRING" id="543379.A0A232EK01"/>
    <dbReference type="OrthoDB" id="409763at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28798" checksum="BE50853805C8FDAE" modified="2017-10-25" version="1">MENKQDDLILTSIENGVQKVFFNRPTKKNALTREMYTRVIEILNESANNKEVTVLVFTGIGDFYSSGNDFISYLTDESVDSSAETVRLQKFIDLLITYPKLLIAIANGPAIGIAATTLALFDIVYASETAYFMTPFCKLGLSPEGCSSYTFPRIMGPSKAGEMLFFGEKLTANEAARVGFVSKVYKTGAIDEVWTHIGKIANLSKESMASTKRLLSQWNKNFLMEVNNQELIELRKIYASPSFAENMMKFMSRKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKQ2</accession>
    <name>A0A232EKQ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_000390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003754">
        <property type="protein sequence ID" value="OXU18898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EKQ2"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF32">
        <property type="entry name" value="IONOTROPIC RECEPTOR 31A, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1272"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1323"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="11">
        <location>
            <begin position="351"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="660"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="11">
        <location>
            <begin position="962"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="1271"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU18898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1571" mass="182428" checksum="C7C12CBEE5F703D1" modified="2017-10-25" version="1">MRAINTENITIFRTCFIFRNPQPKEIKINEILHPFSTRSWYMMLLFLVIFFIIAALTFRYEEELSHSIYSNSFLTVLGALCQQSTSYVMDHLSTRILFLYLMIFSLLTYNYYSASIVSTRLNEPIFKINDSLNELAKTKLKLASEPMIYFNFIMRRIPPRELELFYKTKWLAIPEDDKFMYPEKAIRLVQQGGFAYHTHPDVGYPLIDRTFSFREICELMEVHVQPKIFATIAVTYNSSFIEITKIGFAKMSEVGIRNRQLIRWTSNKPRCRKEVINISNTDIYEFAPHLIILALGMILALALLIAELVIQSYQQSRMRMQRRHCSTILQIVDVLLSFLMFFMITACENQDMIVDYFIAKSTPSVVGFCCKNITQNFLLTRRFDALGVRTIIDNLENQQKIYPMMNSKYWGLGVFLNSNCFSNQTIKWLLSQASNYRLYDELHHWLVLGSSLDTVVNLLDDSAFGPSTDFVIAVPSTLVNYSYEMYDIYNPWKSRGGQLSITRIGMWTKKYRLQFSSSGSKFRRRTNLRGMNLRASFFGSQYRQKDVPLEAYLQEFTGESKDGLSKFGYTILVHLSEMFNITMKFGEVKKWMEGDTEGPLTRALDENKIDITGSPIIMTVERLGLTKFVYPTWPFRTCFIFRNPQPKNIKIMEILRPFELDSWYGTMVMFLLAAITLAFTLRYEGKELFTMRYSNAFLIAFGALCQQGTHFDIKKISTRIVFMHIMIFSLLTYNYYSASIVSARLNEPIVKINDSLNELAKTNLKFASEPMIYFDFLIKVKEDWETKNFYVNRWSHIPESEQFMYPQQGMELVHQGGFAYHTHPDIGYPIILRNYNYREICELMEVHLQAPVFATMALPYNSTLVEITKIGFARMSEVGIRHRQIQRWSSNKPHCRKDVLNVSSTNIYEFSPHLLTLVGGIALASIMLICEIFIERCLNNKRMNLELVLFLCAVAVIVGGSVENDLISDYFPYKMATSVVGFSCNFNNDDISLFKKFSNIGISVSVGKLNNTNYQIQRFAFTSYHKIGIFLDLRCHDKKRSASNYRLYDEIHQWLILGSKIHEVTSIIDDRAFGLSTDFVIISSSKNSKSLYDLYDVYNPWWERGTKLIVTPLGSWQTVEKLNVSLLGTKFFRRSNLNGLTVRALFLTSTTQPANTSLEEYLQEFSSTGRDVLSKFAFVVVTHLSDMFNFTLKFGKVPPRKVGDKLDTIIRALDNNDMDLSGSPTVMNVQRTYLVKFIHQSWPFRLTCFIFRSPQPQTIKVIDIFRPLVMKVWYIMAGFFIIFVWIIASVFRYDSTIRRYLNSFIVTLGTLCQQGTDIKMSQIWTRIVFLVLLVFSFLFYNYCSASIVSVRLSNPIFKLNDSLLQLAQSNLKLTSEWMVYFDLFIKYKYIKNLSDSKHKFLSFIIWSEDIETKTLYTERWIKIPEDKKFIEPNQGMRLVQKSAFAYHTHPDIAYPYVNRLFDNGEICELTEVHLLQPSMATLACPLNSTGTTATSAKASSLNMTEFAPQLFILICGMMLSCTVYTIENAKSLWKIVKEYKKLIKKMSNIAEMIRIRIKQKEKKINTPKVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKQ5</accession>
    <name>A0A232EKQ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003736">
        <property type="protein sequence ID" value="OXU18925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKQ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="8378" checksum="83898022F70227B1" modified="2017-10-25" version="1">MKIGPLVQFIVFVNFHDPKAGLLSSDQLTVTLGFKGNAGLWFSDKPRHFTVKPHAFGAADIARGGARLGLLQTLVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL32</accession>
    <name>A0A232EL32_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003669">
        <property type="protein sequence ID" value="OXU19031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL32"/>
    <dbReference type="STRING" id="543379.A0A232EL32"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF154">
        <property type="entry name" value="FI04917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="54"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="459"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU19031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67799" checksum="263EE7FA8DF28207" modified="2017-10-25" version="1">MTWTPANVTANCSSDPSSCQPSVLAFMAFLVQRFGHSNDEYFADVKKFEPYEEYDFIVVGAGSAGCVLANRLSEIPDWRVLLLEAGEEEPMVADVPAFNKFLSGSSADWGYTTQPQSNACLGSEDKKCAYASGKVMGGTSTTNAMYYSRGNKLDYDNWAKLGNLGWSFDEVLRYFVKSEDNRDADIVSNDPKRHGTGGYLTVQRFPFVDRNLQTLIDAWKELGYKQIDYNSEEHVGFNRAQFTSLHGSRQSTNGAFLRPIRGRRPNLVVKASSPATKIIIDSNTQKAIGVEYSSFDNKQKISKVFARKEVIISAGVLNSPKLLMLSGIGNEKSLAKLGIEAIKDLPVGDNFQDHVNINPFTVIFQNTSTIVSISEVQNDATYWLSTHEGPLSTLGSPSEMTGYVQTSREKNPGVPDILVVTQSSIMTDVENVPANFSAAPYPRSYYNAMDIKLKLLNIQSRGSVELNQSDPVWGAPLIQPNFLSSEADLETIVEGALIAKKFLTTRAFKRANITHYKKPKPACKNFDLKSEAYLKCVAVNYTEAGLHGIGTCKMGPANDPTSVVDPRLRVHGINNLRVVDASVMPALPRGNTNAPTIMIAEKASDMIKEDWSAEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELA6</accession>
    <name>A0A232ELA6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003592">
        <property type="protein sequence ID" value="OXU19137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELA6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="48" mass="5475" checksum="1933573F3E71ACEB" modified="2017-10-25" version="1">MLYSLNTAENSGLLKQRRFPEDYRCDSKHASAPLYLWQAQIGPLASPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELM2</accession>
    <name>A0A232ELM2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003526">
        <property type="protein sequence ID" value="OXU19256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELM2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="7575" checksum="33A9EA4E004E0371" modified="2017-10-25" version="1" fragment="single">MFNKTGWVDNGGATIGNTSLTQPLILQILFQIINRIPGRGEFAGGIDSEALDFFQLEDFINCDSEQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELY4</accession>
    <name>A0A232ELY4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003459">
        <property type="protein sequence ID" value="OXU19373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELY4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012218117" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10812" checksum="43205085222F690E" modified="2017-10-25" version="1">MVFNGHVLTCFILALRSLITLLVKGSLSPDVAVTVYSFLVPAWYSFQASQYFSCARSNNFCALFECSKALSSTLGSRNTSKSTVAKFIHKLIANKFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EML8</accession>
    <name>A0A232EML8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="1"/>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003334">
        <property type="protein sequence ID" value="OXU19604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EML8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="36" mass="4306" checksum="6F2AFA2C4BA01765" modified="2017-10-25" version="1" fragment="single">MIQDLLFQIQFMDQFFLYPLDSTDCMFMSSMKSSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMQ1</accession>
    <name>A0A232EMQ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell cycle checkpoint control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'-&gt;5' double stranded DNA exonuclease activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the rad9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003319">
        <property type="protein sequence ID" value="OXU19626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMQ1"/>
    <dbReference type="STRING" id="543379.A0A232EMQ1"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000005">
        <property type="entry name" value="Cell cycle checkpoint control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="451" mass="50309" checksum="6CC550BAA4DEDF01" modified="2017-10-25" version="1">MKCVIPGVSLKFIARAIHMFLKIGEELCLVPEEDRLSLRITNPCNSAYAEVTFHEQFFTYYAYEDQDAIEDLKCKITIKSAMTVFKSPALLEKQVEACHVQISPNAEKVLFIMKFKNGIIKTHSLPVVDTGSVKAKYNKDGFANHLRIQPKVMNDVIQNFHINLVEITIEVLEDKALIRNYIDENSNICNETRTQLQFGVGEFDEYTVDSDTVITFCLKEFRAIMGLTDAIAQPINIHFDHPGRPAIFICQNNDIETHLVLATLNPDCDTGSQSTTSTAATNLAPKKAPTKRATTRGRGAKSFSKKSFNSTNKTNRTNVNTSTNIPGIENADSPGRISDFGDSPSQNRKDSFDSSRTTITPKTSAEKGTTSGNGDKPNPFSSFLKRKSDQKISSPTRNNDDNEDLVQNSPPRHQSKRAKLIFQKCFQSTFDPRLLPGHNNVEVEDSGEESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENM5</accession>
    <name>A0A232ENM5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003126">
        <property type="protein sequence ID" value="OXU19938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ENM5"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="814"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="894" mass="96353" checksum="252702E786823A1F" modified="2017-10-25" version="1">MEAAGAAPTGHHHQQLATNTQRGLPPGLPGLDVVRALHQTVISLRTALDSSREELRRLKEAAPPDFSSDNYNEAVERLALENHVLRKRLLDRHGEFSSDAATSPPPQQQPPKSAKSVSFDETVTGGQQSPEEPSAKMEAETTEPSSTGGEDNPPAENSEQSAAEQPAPVASDEVDGSGKKEAEDEAVAAADQQEKSASENSLTAGDAEENNEDEEQPQNKLSSQGVSAESENESEELDDIELIFTTEETCRDVGLQEDLVSITDADNWQQQRARTPTPNEQHKSVLKIGQSKSADGGDTMLVCNGGNGINDKAGSVDEAVSSQSSSIDREESVDRFDESSSSRLNHKWSQISVLVETDISKCGMLEEVDLGPRHAARRNTLAAPPAAYSKHNHAVHRPIIHREALAAGRRKSSAPLRPVMDRGSPGSSGPTGTRRESGAQTDISALPAQWRSESYLAHKVAHTFTTLPSKFALPAGVPGRLRLSDKTREARRVMLSDISFTSMVPELSRSADHLCHEPHNQFPQPHCYGSRSGATGVAGSICAGLRTPESNRRESWARGGPGLPSPCDCRLSTDLYSARYRGSLSSIPSPGGDFGPSRRHSWRPNAAASFDGWRTPAVIPGGTAGHGLLGAGGGGGGSMGSSVGGQLTRSTWSSMPSSPTHVQPPSAALVARLASSPPRRTRSKVTFQECPMIRGSLPNLRSELLADNSGDSTESLLDEAEDYLRRSIDSMLTLSTXXXXXXXVAAGEHCSGRHSARRRRARRHSEPDLFREWNPPQDARPYLPKIPRDLKLDHLVKVISPEGRILQGRVRYVGPVAGREEVHVGVELPNESGSSDGTFHGRRYFDCSPQSLRIYASAICNDPSASAIVKRAVYHEQSSRARKLTLSINTYSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENV2</accession>
    <name>A0A232ENV2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003053">
        <property type="protein sequence ID" value="OXU20049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENV2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="18597" checksum="47999EF41CE92215" modified="2017-10-25" version="1">MQADAPAPVQLPTEDPADQPAPLTPPTVDPPDQPLPQPPAPKQVKFAPHLPKRNLKPTIQPIPPTQPTPKRTNLDMDKVSELRSQLKAYRNAAADEQTRADCFPADWELELFESYLRSTLDRRETHLLMAKHHNSSSHPVLYDPQLPQVFAFPSTHLALDILVQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPR5</accession>
    <name>A0A232EPR5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002915">
        <property type="protein sequence ID" value="OXU20328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPR5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="264" mass="30412" checksum="3DDAF0A5659EE6BA" modified="2017-10-25" version="1" fragment="single">MTFARDSINQRPIKKKDIVKLENTYLYYEENWKGLNPDENFSEEGDVFDSDADELSNSLSSISSDENNNDSLMMENSKNDVTIRMIVESFCKTLKEYNGINDSYDALKTNSIQSSYDENMIVEYIHQEDNVSSRAAQCENTVIDTAALENKQLLSRGKFLRPCPEIELLQQKPIKNNKNKANLYPPRKANRQSVIVKTSSHFDCILEILTTVYSLIQTFKEFVHNPTDAIQRIHAEFLSILQSYVSNFNLTSLYNARVKFLTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERU1</accession>
    <name>A0A232ERU1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002558">
        <property type="protein sequence ID" value="OXU21051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERU1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="8774" checksum="9537315F8F14A74C" modified="2017-10-25" version="1">MTNYLENVPHVPLTDRELWNIQLEKIPIIDFPEIKKDIDTSTPSTSTPALSADLTQDDVVLADFGVVMSRNSKMQDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES06</accession>
    <name>A0A232ES06_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002518">
        <property type="protein sequence ID" value="OXU21149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES06"/>
    <dbReference type="STRING" id="543379.A0A232ES06"/>
    <dbReference type="OrthoDB" id="7697103at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="279" mass="32987" checksum="8E2D38F39CBC7F20" modified="2017-10-25" version="1">MEENEEDSTETRWKDTKEIIKKAWIVEERRVKERKLGFRRWWNRDCTRMKWGAKKEYKKWKKGEKKQWKTHFEKLLQGSGTKKLGEKREMIGEKKEGEGITAEEILQAWKDLKKRKAPGWDEIPNEAWIHGSQEIKEKLVAIIGKIWDGEEIPEDWKTGVIVQIYKKGNVNESGNYRGITLLPTTYKIYAEVLRKILVKEVEEKGLEGGVRTVNRKKLWKILEDIGISKYIVEQLKGIYEEPRVRVRTEGGVTEDFWTELGLRQGCVLSPILFCFYIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESI4</accession>
    <name>A0A232ESI4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kaptin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002421">
        <property type="protein sequence ID" value="OXU21311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESI4"/>
    <dbReference type="STRING" id="543379.A0A232ESI4"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029982">
        <property type="entry name" value="Kptn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435:SF2">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52775" checksum="9D7476657BD19567" modified="2017-10-25" version="1">MASEQASHTYETNEDTSDGFSNSRNKNNNLLAGSLPDFFKNLPRLGDKSTMINLIHAHWFPLASQGNIYSLTTLRSPKGSNKVLVASLKRKIYSFEYNQHSKWRLKPLVKELLFTYIPNGAEIIAIDAYNKSNAGDEFVIGITIMKPSGETSIERYLNIYTEGVGEGDESNSLESIAQNCLMVELSYTPYMLYHTIIPQESGNEIVWLISGNDNRIHMIREDKQNHSYTESQLEKYFPELDQLKAIALWVDIYYYNERLTAISCECGLFKLAKVNVGSLEIIQNWILRYDNPISSVRIFPSQNEIRKPAFLNIDYDTKKEVNINVLLNTGNVAVIFQDVLNQQMNSDVLLSGNELTSDCILCSCVADINMDGQNEILLGTYKQEVLVFGPVNNSWKMIDKKLFDAPVHSMSYLDLAGDGVKVLVVLTQRSVHIMQHDIKEIMKKWQDRFLQLSSLMNLSDETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETD7</accession>
    <name>A0A232ETD7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002291">
        <property type="protein sequence ID" value="OXU21604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETD7"/>
    <dbReference type="STRING" id="543379.A0A232ETD7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="226"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="383" mass="43853" checksum="6B20559454367A3D" modified="2017-10-25" version="1">MRRPVTGIEWFSKYLNNTTTSSVATLVAPSVEFQPFRLSNQRIQLSDMANLETEDFRIPFPESDSRIVNDCTKVETHYEEYTVNGNYQSGIITSDIFYTSDPRDDFMWRMSIEVTKFDRNQHVMCVRILLQDNFKEVIDANYSMCILDKNDARTSEGAMPTAFSNHKGRSAISAISVNYLRNHLVHDKLLPDGHLNILCQIKREVKPYKCGIPRDLGLLFDSTKLSDVTLVVKKIEFSVHRSILAGRSPVCASIFDLKMIESKKDMIEILDIEPEVVKELLRFIYTDKVENIEVLGLEIFIAADQYALGDLKFECEDALCSSIDAENDGMLLKYADRYGSHRLKSEARKFIFENAEDVAEVEGYDAHVDGYLTFLMRILPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVJ7</accession>
    <name>A0A232EVJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001988">
        <property type="protein sequence ID" value="OXU22376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVJ7"/>
    <dbReference type="OrthoDB" id="6596404at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22866" checksum="0E982AE1A8339FEB" modified="2017-10-25" version="1">MHPFQSDRYYIPNRGGCLYHVRQCLQSALQLRELLQRDMAGSSKTIGCIGKCTSGLSLKELDWITDNIQRTLADEQGRKIFRKYLSRGRRKTDLACLDLYEQVAEYIDNECIHRLSTKSPSVEPLLADFNLALSAAKDLDDVSEIDLTLLERYVQAADSRSRESMLDVLEETRFKMMNHLRQAHKGFQAYAKMPCPQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVY9</accession>
    <name>A0A232EVY9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_005494</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001939">
        <property type="protein sequence ID" value="OXU22503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVY9"/>
    <dbReference type="STRING" id="543379.A0A232EVY9"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="218"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU22503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="511" mass="57159" checksum="665BAA447797E686" modified="2017-10-25" version="1">MKKITHSVKTTTYATTSAPSISLSLVLAHFLESLTTSHTLTPDRLVPLLLEYYKSRALNPARGQSSHMDSSRGFDLLLLLLLVVGVVQASVLQRSRAGHDDDYVSPSFKDVEIPEARVTYEGAQVWRVQGADDYAEYLTYLQDRGDLSLWTGNDTTIDVLVLPDVIPRVSRFLHQRHVEYDVVIPDLQQAINHENPIKTPAEIEELEGRHGHRMEWTSYHRLEDIHGYLDYLANTYPQLCSVMTIGRSVEGRELKVLRISKGTANAPALWIDGGIHAREWISPASVTYIIDYLVEHSDQLEADYYILPVVNPDGYEYTFRGDRLWRKNRGNPQKGGSCIGIDLNRNFGYRWGGQGTSKQPCRETYAGTGAFSEPETRAIKNFFEASAANFKAYLTFHSYGQYILYPWGYDRRVPPDYKDLDNVGKQMAAAMRAAGGANSAYTVGNSATTLYAASGGADDWAKAHLKIKYTYTVELRDKGQNGFVLPAKYIKPTAEEALAAVKVVTQAIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWA1</accession>
    <name>A0A232EWA1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001890">
        <property type="protein sequence ID" value="OXU22629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWA1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="181" mass="20064" checksum="A9BF938100AE54A5" modified="2017-10-25" version="1" fragment="single">MFDCFENTRVLSRLAENNRVGRFPGTRRNKGSNATTLSAPGNEHAAASYMCSPQRRAHLNADRREEDDDFACIILAGHALPRRHLTAAYRESSIRPTLINRGTFFSRADVGSWLDTSGRKNRRIYLESQHTPTSGNYGSLLSNETRGRKGLAPAALERGGNKVGITRCLSKILFGRKAANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWL5</accession>
    <name>A0A232EWL5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001848">
        <property type="protein sequence ID" value="OXU22736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWL5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="7020" checksum="5008C87AA17A0BA8" modified="2017-10-25" version="1">MSSKTNIALTSPVSSSATNLQYNINIKTPSPIQNRRKIKIKRRLNQICSQMSEIKLSPHPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWT9</accession>
    <name>A0A232EWT9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo repeat-containing protein 6 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001821">
        <property type="protein sequence ID" value="OXU22819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWT9"/>
    <dbReference type="STRING" id="543379.A0A232EWT9"/>
    <dbReference type="OrthoDB" id="449062at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="369"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU22819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50919" checksum="1EFEBCC1BE68699F" modified="2017-10-25" version="1">MVRVITQETYDEVVQENIKEFSMSPEEAIKDAIDQFNAQGVDLSNIIKDLSLNSTTDDITSCIKKLAECAKTAEHEHATPLLNKLKSELEKDIARRVFAGKNGAYTTLLEVITSCKDEPLLLRTALKTTTVLMTGNPDLLDDAGVELQKSLLDSNHNDPQTLQLILKWIKECCMKHEINRQMIFNAGVLENLKSILHEKDANVAVVKEVCVVLRALTLDDDIRHAYGKAHEHAATIARQTLRTLTGLLSIYKTDKVIVGEIMLTAASIIVRNEFCQDFEDAGGLQFILDVFTNYPDVEKINWQALKLLKNLAGNDDVKAHIITSGIAPLIVYAISRLRSSEAVVTAGLACISALTLKSPSNAGVFYDCGAVPIIIDAVKAYPNSANVIQQASWAVRNMSVRNKHESREFIAYGIEDIFNSALEKHGENLENDLKAALRDLGLKVNLKEQWTGKGRVLTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXU8</accession>
    <name>A0A232EXU8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_013385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001658">
        <property type="protein sequence ID" value="OXU23296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EXU8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000166">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF77">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759820" description="Peptidase S1 domain-containing protein" evidence="13">
        <location>
            <begin position="16"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="30"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="307"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="563"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="789"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="1248"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU23296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1484" mass="162028" checksum="EAB49B304AA32072" modified="2017-10-25" version="1">MKLLYLAFLVVGASAFYVDNESDAQKKERIVGGRKAPIESLPYQAQLLQNNVQICGASIISRLWILTAAHCITGKNPKFTVITGSASVSTGGDLHHVSEVIVHSEYDKNTEDNDIALLKLTKPIVYNERQKPIKLSTKPPNAGDLMTISGFGKKGEDQGYAIFLETANVPVVDHELCARRYIEDPITDNMFCAGVGPTDACQGDSGGPGVINGELAGVVSAGQDCGSTYYPGIYTTVYNYLDWIAQHTRTPTVRPTSRPATAKSTSIVIDPSNTILGKIVHKVSLTKANNHEIVFSYAGDVLQEPKIVGGYYAKINSVPYQAQVVQQGIQFCGAAIISEYWLISAAHCFANKKDLAIRTGSKFRSEGEIHEIEKVVIPDSYDPITLNNDISLILLKNPIRFNANQKAIALSFSQPQIGDKITISGFGKEGERRGLSSVLKVAQAPVVDRRLCAARHQPDTITNNMFCAGVGNTDACQGDSGGPAVTYNKLVGIVSWGQICASKYHPGVYTKVYNYRNWIRRVTGIRPRVLLQTKMNTFLFLSLLVGSAYCFYIDNGEAQKDKIVGGDYSSIEAVPYQVQILFNGVQKCGGSIISEQWILSAAHCFDDDDTITVITGSKQQEQGQQREVEKIIVHKEYNTETYENDIALLKLTKPIKFNAKQKAITITSTPPKVGQNIKVSGFGDVKDGGPDSPLLKAALLPVISRKVCQKANSDDDITVNMFCAGNGVDDSCSGDSGGPAVIDNKLVGIVSWGYKCASRKNPGMYTQLYRYRNWIAKNSDNGEAPKDKIVGGDYTSIEAVQILFDGEQKCGGSIISEQWIVSAAHCYHNDHVVTVISGSKHMEKGQQREVEKIIVHSDYNSNTIDNDIALLKLAKPIKFNAKQKPIAITTTPPKAEQTIKISGFGYIAEGGPDSPLLKAALAPVVSRKKCQEAYSDDDITENMFCAGKGATDTCEGDSGGPAVIDNKLVGIISWGYDCGSPKNPGLLCLSLTLLIAGANCFYVDNTGREKDKIVGGDYVPITEAPYQAQLLQLGSAICGATIISEYWLVSAAHCFEDTYGMSILTGSTYRSKGGQKHQIEKVIVHRGYDEYTNDNDISLIKLVKPIKFNERQKAVPLARVAPKTGDKMIVSGYGKEGEYQRASTTLKVATVPIVDQKTCARRYIRDPITNNMFCAGKGPTDACQGDSGGPGVIDGKLVGVVSSGMECGSTYYPGIYTRVDKYYEWIVGHTGIGHCFYIDNDEKSKDKIVGGEFVDIEEVPYQATLHWFNAVVLCGAAIIDKSWILTAAHCTYKKSHLTVRTGARYRSEEGHRHKIAKIIEHPDYDDKTVDNDIALIKLETPIEFSEKERPIGIAKSYDEPIEGLLMRVTGFGKISENGDTSSILKSAYVPIMNQEKCEKAYFLDPITKNMFCAGDGKTDACQGDSGGPAVVGKKIYGIVSTGMKCGSSFYPGVYTRVYKYYDWIVEQTGLNFYLGHLCIFYIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY41</accession>
    <name>A0A232EY41_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_003180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01001682">
        <property type="protein sequence ID" value="OXU23237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY41"/>
    <dbReference type="STRING" id="543379.A0A232EY41"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU23237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="667" mass="77665" checksum="4FDAF4F08B380385" modified="2017-10-25" version="1">MQHSLTHCCPKNGCNKILHFCSRRSLYFIFATLRILLNFVPQTGYIHPDEFFQFIEVASGDAFDIDVYKPWEFNITFPVRSSLFPQLCVRLPYFILEALTPYSEYFFGISLKTPYFLVLFPRLMMTILSFVSDYCLFKICIIFREPYVDRLTIFASSYVILIYSCRTFSNSIEIILTSILIYHVSRCIEFSNKVVLQSDYLADKYYKARTGVERAKIYKLRMSLPPHSLNYCLLLATITVFGIFNRPTFIAFAFPPIFFWLHRGLGSKTVGFLDFHIRIFVFVIFSIPTVIILILYDSLYFGYLTMAEVGKFEISMNNFVVTPLNFLKYNSITDNLKNHGLHPRFLHFLVNVPLLFNVLGVIAVLTIVKMVNSGLRGRWLELPRIQNIESLMVSSFAVPIALLSIFPHQEPRFILPVILPLIFLFSHYIKCPEIGAVNVANKKKPMPSKLVKENKFGLKGVWYLCNAILVIFYGFVHQGGVLPLTSHLFKELKAKPYLMHIHLFTSHTYPVPTGILHLRNTKRTYTSDSGHKYTLTKDFNIYELGSKTVDTIYDRISSTIEECEKDLHFKRVPYRLYYALPYSLYNEFADYVLNNETQSFKFNLVKSFYPHVSMEKLPELAASWDCLNMNILQDCSLNFIDNVSENILNYLRQFTLVLLQIEYKNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYR3</accession>
    <name>A0A232EYR3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001613">
        <property type="protein sequence ID" value="OXU23427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYR3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="6978" checksum="F8740FF6D0FEFF2B" modified="2017-10-25" version="1">MLESEDGGIVGLFADGATALVGLEEVLGAAHGLAGVLPVALAVGGGLSQAAGGGTGEQGADDLGYDFHGLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYW8</accession>
    <name>A0A232EYW8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_003218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001589">
        <property type="protein sequence ID" value="OXU23499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYW8"/>
    <dbReference type="STRING" id="543379.A0A232EYW8"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="729" mass="85924" checksum="5E44B4BDE160F29F" modified="2017-10-25" version="1" fragment="single">MIPVRLKRRPRSYTNKNHVCVQCGNCYAFLKSLRRHLRYECGLAPRFRCPYCNSTGKQRAHVKEHIRRKHNGRKLYVSEFLQASISSNPGYRRIRLSREPQPPPPPVIENVYQRLPRNVNSSPGRFPCDRCGKVYRWYRNLTTHLRLECGKEPSVVCPYCPRRTKHRNSMRSHIQPPLFPIVRPRLHVCPRCGQMYSWASNLRKHLKTGCGTVTCESHFSCQYCPYRSRVEASFLRHLMSVHNINSSRMNDDSTHEAYDDLGLSCDRCMKMFYSQYSLTKHLRFCSTLKQYSCFLCEYRSNRKWNVKSHIERVHGKTPAKNKAEKLETPEFNTFMTAMRRPMRGFMHQPQQRVTYPCRNCGKHYNYHSSLARHLKHECGVEPKFQCPLCPYRTKHRSSLNTHLNGKHLKRRSGDTGFEILADRKFPSDDSTEKIETVELPSVPLPGHRRIYGQGHYVCPKCKRRYYNLSTLNRHAKNKCGLIGLRSLKEFYRISKRWSSNSTSSLKPVSDFKCENCNRTFAVHRNLTRHQKLDCTAIKKFSCTTCPAKYSQNIALRRHFTLPPEVWKRCKVNLVCLKCCKSYSDWRSLKKHMNYFCQVEPLYPCPYCSYRARMNTLLKYHINREHYTYYYNEQVVVKHSYEPTDPLSIRPILLSSNQLRADNVIVRIAAGVYGCSICDYRSSYKTNVDRHVRNVHSCNETPRFKCKLCDFRSKYKSCVDRHLRSFHKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZG6</accession>
    <name>A0A232EZG6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001507">
        <property type="protein sequence ID" value="OXU23755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZG6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12871" checksum="B50D9A9D44ECC4F9" modified="2017-10-25" version="1">MHYMRCIGEKKSLISKDFDPNKYREEVAHNLFLKSENITNSCLYCSSKDMNGTAKCTVCTRNSHKKCIEKAYLREQKLIEKIQNKKFKTKKIEPKHTIIKSNYPESKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F016</accession>
    <name>A0A232F016_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C19orf12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001466">
        <property type="protein sequence ID" value="OXU23870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F016"/>
    <dbReference type="STRING" id="543379.A0A232F016"/>
    <dbReference type="OrthoDB" id="5976774at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033369">
        <property type="entry name" value="C19orf12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493">
        <property type="entry name" value="NAZO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493:SF1">
        <property type="entry name" value="PROTEIN C19ORF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20721">
        <property type="entry name" value="C19orf12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="139" mass="14621" checksum="D6F2B6B78534E891" modified="2017-10-25" version="1">MSIATPDLLNAISDLATIREMKVAVSVTSQCGLITAVTTMIGGLIAGPPGIGIGGLVGTVAACYHSNGKFKSVPEILMTEASPEQKEKLADAVRNVLTAENILTLVQLAATIQNNRMLLDTIQKVVRDFLTSDMGYCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F023</accession>
    <name>A0A232F023_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001452">
        <property type="protein sequence ID" value="OXU23929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F023"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="10000" checksum="A8339A5FA3B17C78" modified="2017-10-25" version="1" fragment="single">IVFWIVAPITRGLNNRLANPKHEADSDNISEKTLNSTGVRPLRPRIPCSYHCATTGLRDYLQRRVVDRHLGRAESVKRMSPPFCTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0I8</accession>
    <name>A0A232F0I8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001452">
        <property type="protein sequence ID" value="OXU23928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0I8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="58" mass="6335" checksum="FE29C764A6571EEA" modified="2017-10-25" version="1" fragment="single">IFCYPIRLVFLTSPVSAGARGGSPVLTEIALLAAIVPMRPSRNPGSLLHRQNRRACCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0K3</accession>
    <name>A0A232F0K3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001377">
        <property type="protein sequence ID" value="OXU24181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0K3"/>
    <dbReference type="STRING" id="543379.A0A232F0K3"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="201" mass="22119" checksum="2E3F3F7F2A721D08" modified="2017-10-25" version="1">MSGMLGLIVSGRLVQTDFQLVGENKFLITIPDADSINHVVVFLTGTVPFIDGMGGAVYFSWPDPNAPPNWQFLGYVSNNKPSAIFKISNLKKNHEFENNNLGIFGATSTTISHVAQIGISVEPLSILEQQAAVATTNATNSFVEFAQKMITSFLNYVSSFSVTQAQMTANPTENFVPLSSIQGWYETFERRLAQNPNFWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F154</accession>
    <name>A0A232F154_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001339">
        <property type="protein sequence ID" value="OXU24312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F154"/>
    <dbReference type="OrthoDB" id="7700178at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="402" mass="46504" checksum="B6D81D7BBEC19A5B" modified="2017-10-25" version="1">MDTAKVNNGDVLSVGYWKLNKLMLKSVGLWPYQKSSTKMCIRTFIFIAIYSMMIPQIIRTFEEWGKNSEIVIENITGFLYFHVLITKYVTSCITESNLQCLYVRITEDWNHFRDEGEQKVLSHFASHGRFLTIGYSVYLYTAGITFTTLPCLIPAVLDLIIPLNDSRQKVLCFYGEYFIDQKVYYYELLLHTFVCVMCTIMVFTTIDAAYACCIEHVIGLFHIVDYRLNQAFNLVKDKYDTKSEGMQSEIHKCVLRSIEVHNHSIEIVELIQTTYTTCFFFTTGISLICLSLATVDMMLSVNNYINFSRVFFAWCGMVIYFFYISMPGQRIIDASLDILNSVYFCGWYDFPLKTQRLLKFMMMRCSVPCQFTAGPLLVLNLENCGVILKTAMSYCTFVFAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1H3</accession>
    <name>A0A232F1H3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_009626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001352">
        <property type="protein sequence ID" value="OXU24268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F1H3"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="818"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="971"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1286"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1076"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1326"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU24268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1338" mass="151519" checksum="FA88E085C857E32B" modified="2017-10-25" version="1">MLERALTQPQQCSVDPLNNAQTWGIPIWTSCQLLTWLEKISASLKDTTSLRRDSHAGSGKDLKVKQLTEPYIKFESYKRETRPVFLELQAWPTLNFDGDPGSCPFDLKRREKKEVSINKEIKENREKYFNPNLSKGKDMTRRPRATTTRARKTENTGYCEICRIDYRNLSKHLQSDQHLNFVRNDKNFLSLDNLISTGASVEAFLKINRSKDVSKACNLFASRDHSLENGILSADEKPEKKDKSSLNEFGIDDMKMIQCNGARRNLNLDSHHNLRTRAKHESGHLLRSKGKPSDEVEKSEKSCEKFIIKKRAKGILWIEENDSEEEKCMENEQECGDKKPLLDRLCETEANKAVDDGENTPENVSVNGDVDPDTADCKRKESSPTKVITKDNVLRDSLLEVNSKIKVNGYEKREEKRKVSEVLNSADNNETKEVNHVEPTVDSIDCNSVDTVNNTEKPSLFDNEDTNSLKSVSRDDRGKIRSSRRGGRTYKGRQRLSVEERLIEDNREYYKVEVLGNKLRSSAIPSSNVCVSPSKQEEADKAKKDDKPSSEKPVVVRFKRVRKSELSLLSDEAEMFMFGDSRRDDESSEASDGEQSSVLPQDTESDGVEIVNSFVVSSSPANASIKIEKQELTEDESQDSCSGRAKKRRRTQTEALIKDNTDYYKFETPGSRLRYQAPLTGISELVPEKDEAQSQDPAATPAVVEKVYPSKPSPEVEKMHFSFEAVPKSEPWYQTYQRQDEGAEYYHFFSEVEKPFLLPYEIEDFHEIIHRTIQNSMKKRGRSRGGHVNLGTRSPRKSPRCHASTLAIMSTIIKRREQTTNLSTIEEEKPKVNETSKSEKKSSEKSDVDEDLKEIVKNLDEMLSSNDMQDMDSFEVDLLKNAEDVIVPEVPKGAPVNLIELLDQCHDAVPNGIENSSCASSECGELNVESPAKRRKKRKNKTGWPGNKMRRKLHIKNLSEELQKELDLEKRAAEEVGNRSVTDAEITEDGTSSQLSHDEEGNETEHETGKENEQLLNTIEGSKPSKSRKTKSKECKEFKEPPQDLSELKESEEAQDKTVLKSVCADEISTRKKRSASSDKCKVESEEEESHSQELTDRGGPLSSISEDSEESMSNNENVCTKDANSLIPLEKNSPLKFCRKRKRNNTTSSEASHHTEIENRRSGVGSSPKKQQKDSSDNTQDLPLSSRKNSRKRSKKNRRTPSKVVLEGENCKKESFLSASERKRLKKAQRNDSVSSELRNGEMDPALSERISPTLVASSDVDQRRSSIDFQPVVRVMKIEDQVDMDSNSGSMLSVAVASNRRLRSSSSPRSSMQPPAKRFRNGANRRQFSGQLIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1Z6</accession>
    <name>A0A232F1Z6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001205">
        <property type="protein sequence ID" value="OXU24744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F1Z6"/>
    <dbReference type="OrthoDB" id="2281547at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051999">
        <property type="entry name" value="Mediator_complex_subunit_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12881">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12881:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="10">
        <location>
            <begin position="84"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="549"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="857"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1336"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1501"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="593"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="948"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1340"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1365"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1421"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1509"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1536"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1559"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1589"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1631"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1654"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1688"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1753"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1764"/>
            <end position="1780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1872" mass="196080" checksum="6321BE40D053744D" modified="2017-10-25" version="1">MTSALPVNGFIGPNGAQPALAEQTTGGGVVSSDKSKEWQMELLMEKLRSKASSFKSLVETAKNIRMTMLDKRFGIDSVEKNQLQKSLDALQHSIRVTSLQSMIERLESLSRQLGLKFVMSGPPTTTNTELFISSDMFFLEVLLEPSGAVKDVKIHHDGKNEQQSEELVACLSRGDFVDFTTQLEGLASIYQLNADKKVKGKAFSALQSLETDLGILAELQKFMKEPFNVVHKSPVGILERRKGGHAMKLTYFVSPYDLIDQENKSCEALSLEAVISKKVGHSVTVCLEGSTAHKLPTSSIITVTRTPTGKSTPSYASLTSANSSMLPACFVLKLAKKMPMCLELIRKIQKVTDLECTDISIPYPLLSMIVQHTSDKQLDCQNNRGLTVSLPDQQHCYFMTENRNMEGVLVGSIPFTHPAHVPQILNVLRQQALFNTLISSCVRPMARQDSEHTTIFEVSALSWQCISVSLEHPFEETLATAELDLSDISALKCKLYGVSITNTEQTSDLAGKVLQRCLSVPLTMRTLIKAWEGRTFMLNPIGGGNNSFNSNLGNGREQNNHNGSNVPEFGNEDIIIKQEPGTGMNGTGSTGRQQQQQAPTQQQQPQQNQQQNQQQQQSFLEAGAENSIGFPSFSGSSDTPPVAMLNPLQLGALSTTPTPSGDGKSKKSRKRKAADGSWKSPKRKNDLDSNEILLESSSSDSTPLGTPQDAINDARTPTPTSAASIASGGLDLSNLDPLDVMSTDKSSDYDLDNDAEIMQVEPTVASLEEALKRERKLKKRAEEKPSPTNVFEDNKTLVSPSVSITPISSGSSSQSASYNSMLTSIGLDRRPGIEIIPIASLPQTPLLNSITITAINNPAKSSTSSSSTGSSSSSSGTSQGLGDERSKERKSSKNRSSSSSLEDKNKLEKKRKRKRESSPMGPPGKLPLKQVSSNVDPLSKPVSVSIKPASESPPSSARPSSPATTLHKFSPSPTRNNPLVLVGKSSPTSLKQSSSSSSSSGSTGGNGAGGGSGSKPVPSPKHSPVYSSPKHMSSMPSSSVSPKHGTSSPKHGNSGSAGKPSMSALKSAANSPSGKSSDGSGVSSKAKISSLQSSTSPSSSAMSLSTLSSSTSSSSSSSLSSKESRDKEARKASSLMFGSSSGSSSGHQSPKSKSISSKPKAIDSEQQQASLSTGSGGSTPPSDPSKSALTSTQQQQQQARNRKGSLSAVIDKLKNAQHCTDDAMGSSGSNLAPSSTTGGSSSSSSASNSAMKNPSDAKNPTEYMVKPSSDGMKLTINKTRTKDLKSNSSGLKLSSVALGGTSGSAGGLTITPVTMPGNILPKLFSGLKAGVISGPVSRKPQVQSSAKVRSTSPLTSSSGMGSGKSGLASGQKLSSGGLKSSSGSGLLSSSSGLAGKSLSAKSFSSTGGGSMKQSSIAAELGRARDKARFKTAGDKSFAGKGSDLRKSNPSTVESENEKALRQHLASNILASPMSGLSNLSGLMVEGLMKQLDTKFQIPKLSARANAADNADKRSVDKVDSGSKSSDAPSRSSQIMSNPAVSSSSNVPKLEEAHPAIAHGASNSVVGYGAGSASTSSSSANTISAHESDVPTNLSMQPDETLQMKAEVGSGRPFLNPSGESSKEGIDLAGSKHSSYSMGSDTTGNLESLNLVTKGSEKYKSSDDKDQQQQQQQHAVFHRLPHADKKSVESSITTPASITLTPIPPVSSSASAGGSGTSSQEAAEMLLDFSTPKESGGGGGSVSSLPLKSAMSFAASSSPIRKNTTPPPPPPPPPLPPPPPPSVSPAVLAAVPPSVSPISSFPQSPSVSLHIVKSPAPSPRVIPLSPHSASPCITDDELMDEAIVGGFRIPNPYFIMLLKLRSYRVQLPFAMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F257</accession>
    <name>A0A232F257_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_014053</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001286">
        <property type="protein sequence ID" value="OXU24487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F257"/>
    <dbReference type="STRING" id="543379.A0A232F257"/>
    <dbReference type="OrthoDB" id="5818798at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU24487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="14575" checksum="73F3E21E9A92692A" modified="2017-10-25" version="1">MSNKITGADEIYDVSAREKEVIEWKANRRLELRNLYLREKFNPNSPHVGHIFDPAVQRHYSTLFCKEQFFRPTVKSFLWNVVVLGGSMFFVGWRVKKFRDEKEHRFATGQVSYRDREWKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F283</accession>
    <name>A0A232F283_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001261">
        <property type="protein sequence ID" value="OXU24578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F283"/>
    <dbReference type="STRING" id="543379.A0A232F283"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="179"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU24578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="339" mass="36920" checksum="91A5F392F6CDF869" modified="2017-10-25" version="1">MARKNSAAVLHGINDLRIEPVDIVEPNDNEVLLKMASIGICGSDVHYLVHGRIGDFVVDRPMIIGHESSGTVIQRGKDVKHLNVGDRVAIEPGVPCRTCEFCKSGRYNLCQEIQFCATPPVHGSLRKFYTHAADFCYKLPDHVSLEEGALLEPLSVGVHACKRAEVGIGSNVLILGSGPVGLVTLVAAKSMGAKKVAIADLMEYRLDLARKLKADVVYPIVNTSTEQENVDNISKLMQCQPDITIDASGAESSIRLAIRITKAGGKVVLVGMGKPDMNIPLGDALVKELDIRGVFRYVNEVKFASQELPQCPAGKNNLMKIMCRNSCTDLYTYLWSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2P0</accession>
    <name>A0A232F2P0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001223">
        <property type="protein sequence ID" value="OXU24687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2P0"/>
    <dbReference type="STRING" id="543379.A0A232F2P0"/>
    <dbReference type="OrthoDB" id="8063677at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592">
        <property type="entry name" value="PBF68 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592:SF31">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="278"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="407" mass="46833" checksum="1A3F0770A55C947C" modified="2017-10-25" version="1">MAKDVVGFVKLNENNYLDWKYTINVVLRAIELDSYVFGDKKQPNKLEKPAEWKAWKMKSLKSLYIIMDSVERRLHRYLLHCESGREAWNEIKLMYGETHAGLVPLWQEFHEFRFKDGVKVTEQVDNFGKIASKLIAGDAKLDDAAIQAKLLSVLPKAFFQVRIAWDLIPPLRRNLDDLYKLIMAEEKHLAKKLKELESLKCALKRVKIEDSGDQTEQHKKIGNGKKKLDSEQRTRCSICEERGHKAEECALKKRAKTQVIASVSGVCHKTADSDEDAWLADTSASTHMTFRKDFFISYEPLSENLYLKVAGDRFLEVLGHGTIIVTEKIGGKIQERKMHNVLLVPELKKNLFSVSAIIEEGYSFYTVKTYCEVRNSENNLVHRGVKKNRGFFKMLFKIKSPASREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2P2</accession>
    <name>A0A232F2P2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001144">
        <property type="protein sequence ID" value="OXU25001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2P2"/>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01460">
        <property type="entry name" value="vWA_midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000028">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="3215"/>
            <end position="3408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2516"/>
            <end position="3076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2554"/>
            <end position="2569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2570"/>
            <end position="2585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2593"/>
            <end position="2609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2627"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2640"/>
            <end position="2689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2690"/>
            <end position="2700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2712"/>
            <end position="2743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2756"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2786"/>
            <end position="2796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2797"/>
            <end position="2808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2821"/>
            <end position="2835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2856"/>
            <end position="2872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2875"/>
            <end position="2894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2907"/>
            <end position="2926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2927"/>
            <end position="2951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2967"/>
            <end position="2982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2984"/>
            <end position="2998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="3022"/>
            <end position="3043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="3049"/>
            <end position="3073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="3420" mass="392024" checksum="EF6064FFE9721555" modified="2017-10-25" version="1">MRGIFLWEMPIRYFHFCCRQYRIDCVLTCTTFANARNDPLHKFCQVVDGCTLLIYLVNISPSIILAYNDLLRCPKNTIYKIFKLLKIIINVTASLLNLSFFSRILQTDYNRHLEQLVEKTENLLTHSLKTKVSKENISQIEKYQALIERVRDLSHDDCESVTMALATSLFLQKIDELLKLLNEMKSLENSVLSEIAQIEGNLSKLKEFVEQDKCLNAGGKFEWVDSILVKCLQEGTWLLIDQVNLCSPAVLDRLNGLLEPNGVLSIGERGVDSEGNVVTIKPHENFRLFLTMDPRYGEISRAMRNRGVEIYMLNYNENPETGKLDYRSLLYNNGLTKRNHQEALMTIHKEVSEDPSNVDNLNVIQLLHSAFLVVQQLARGFPVLEAFKSSCTDVYLKARSVFHQETRMRLASIIGDNIQKFGINESDDYVLDLNAATCTLKNLQDNSKLTLLRQEGLLLDWCVQGYCVGWSAKNESAKFSLKTDLINEFFAAVADQNHIISVEVLDILPYILLNFYEHSSVSDVDFREMWAANIFQKNSNLEFLEKKNSTLAQEILAFDFEDCDLKLPWDGKHFANANNLALLLYYETLVVDDNMDRGWKVEGRQNTISLAQFSEAHRQGKMTGSNLKNQILITKYVSFLLQVKKFIDNILRYNKKVIDNSKYVALRQNLKYFNRFCDLGKMILLNKAESSQNLLKQIDEVGLLLKVHYKWLKKFIRFLEDNYEGHKLNTDYKKESDLVKALMNEIDNSLMSVYDPFRKICKIYKKHINSPLPCSSDIVLKTCSSLQEITNSFSTSRNKYIKANSLSNEPKFITLQTDEALNIRSELINLWHNIYANEVLDENVSETLQNMTDFCATYLNITETPKESEVRAPSPKDIVKMTTKIQLWPIHEYMFTLFVESFRRKLCEKLTEEGDNVSLPSTYLSSHHSCLPNIPAELLAILNTICTKQDDPQERNRLLFALSIWFSKFTENSYAIKHFKQVSHWRSISSDQKDDSAYLPEISDRENLTSGPVLVSLISELILNTSQSTNPEKSAIVTGATLGSYSARLEQLKTLNDTLWKNSVALNSLQFNHTSNDLITLRCLLKEFLACCDRVEADSSLKQSIESEKLPPSVKSTVSKEYLQPLEDLRSISETLTTETSSLNRGKTWTLLGYLQAFVFGNMSYIDPVYKVAIKLRYVEEDVNDCENTLYVAKLYSRILGLLDNHIAHPRFHAIEANLEQLKEEKDSLQKLKAVRPANAEFIALSKEFTNFRTALGSYAIVDKHVQKLIETTTNLKNEVNESNIQSARSTKREAEIWLESMRRFMDQIESRFLSGYPDIVYPILAGLAQMRHGIRILIDESSRLVAVAESKFDSEKLGSFIRDLVRFPTIGPKQENLLSLVELCTSHESRELLSVNMKTENTFVTLQEQFRLTIAGLYEFYNYIVLKGNLTKDLWVQLNNLLQQIVLIWRQQQTEMEKREAEKDSLYKNRVKVKGESLTEEEQIAQELKSLFPTHREDDFADVDSSLVPTLEKKVTVESKVEDFGALITENDIKEVQNIHSSIIKSFTSSEWLLKNANESRPDFIEPLLQRYNTFGLLLDRVAPALNHKLTSELYTSLNVLTQLVARLGQGETLNPESCIKTAKKSSKLYDYYKDSNVEEVKQCVPLLERISNKITELLNEWPEHPTLVSIRIILHRIYSFPVTSAVSRFLTGLEMLLVKMHEWEENAHSGVSLTEFILSLTQQIISWRKLELACWKDCLITAQLRLRSQTSKWWFFLYDLFESYVSKNPSSENPKEDAITTKKLIESLEIFMRESSFAQFEARLELLLTFHCHTYYLNPSVERDNALAISWNIYNYYSQFLPDINNRISAIKAPIEKKLKDFVKIARWNDISYWSVKETVEKTHRTLHKHIKEYETGLKDVVTPFLVVKPTYKSEAGIWDKPKADHDSSVDPNDYLAPTPKLIITDVTIKSDLISRVDSHYLSRAKKLCKEAILTSMYPGLRMSLEEFIEEFMSHSARLRALEIDRTQLQPKQKSQAKNILQQKRMALADYFKTLQGFGVSHRIGVLAWKNRLDEVLDFTIPPIELRTSFNSAGSGIIEKKTLEQWEGCERYYYNSLIKLNALDQALLSNKTDLGPQNMEWCKGFSAHLMLLANKQKKVLASVLKYFVRVRSQVLNLSKINIDDLAITKQKDLWHSAINLKELLITSRTILEQFLVYLQACPTESQIEGDDYSYNLDTNDLPIVNCKRGDELWEKTNTYVKECLIGIADLSKKFNSTFSELDIINEENPTDDVQASIMTSKHFAFLKDNFGSLKNIREKINQFAAIFDAVEDGKHPLLENITFLERNMANQLDQFEKINTHVNEQSESESPPEKEVLDKCESDFEKLVSSILLVIQNKYKDNLATAIEKDDKNESEREKEEEDTEDEYEKNKLREKLVESIEKDIATLKLKEIYEILDGLLRIILNGDSKVIQSGCRLLQKCLPLLQQYLLLAQFYLNEQVASLRITCKILHMQLNVFLDLATNGFCVPKDLDLEEGDEGSEEKTGKGGMGLGDGEGEKDVSEQIETEDQLEDAKPAGQEKEKPEDKECPEEDNGIEMSEDFEGQLQDVEPKEDEDGNKDEEDDEDIDKQMGDTADGSDKLDEQIWGDDEDEPESEETEKKDDEIGDGEKTGEKEFGAKDERTTEDSDEKGNDDQDEERKEEQKEINEMEEPEYDEDQVNPYHGKHQPEPEPEPLDLPEEMNMDDEDDAKDEEPNNEENPFDIDKMKEAMPPPEVEEMETAEEEVQEDKDTKNQDSSDEEDANDPEKPADKAEQEDGANEDENEEESAQKAPDAGKENPEEEETKSEEKEQEPEEKALPSTDEASKEMDAAEQADQQEGGSRDQVANQAENEPDQKEESSAENWQDEKKDKGTGQSQAEQHDSGHSGSSAEKTQPTTNQENEAQQNEKRKNPGKSDEDHTLAEKIEPDKKKLRTMIHSKDKAPEDDNNEEGAEQEEEGDPDICQHVKEKEKFDHYAVDAATEEQSKEQASNMEQEKEPPKDEEEAMDVDMHEDEEVEMEEEPASKQNSEKVSTDDKSKDKKDSKEKGRTEDGQLETVVDVEGETTETMTVQRGAESAFFTNLTEVENELLSTKWIEKQRMEVEKMLSQWTEVPTTEEAVAAWNSLSAVTDAPARDLSEKLRLVLEPTQASRLKGDYRTGRRINMRKIIPYIASQFRKDKIWLRRTKPSKRDYQIVLAIDDSSSMADNHSKELAFESLSLISKAMTYLEAGQLSVLSFGEEINVLHPLGETFSEHSGSRLVQKMRFEQKKTMVGELVNFTVDMFQSQSNSTDNAKLLVVLSDGRGIFSEGTEKVNLAVRRARLADIFLVFIIVDNPLNKDSILDIRMPVFQGGKLIAINSYMDSFPFPFYMILRDINALPGVLSDALRQWFEVVGKIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2R2</accession>
    <name>A0A232F2R2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001135">
        <property type="protein sequence ID" value="OXU25021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2R2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="56" mass="6384" checksum="04D20E0AD89E3470" modified="2017-10-25" version="1">MTLKKLQDLVVGTILARKYVKYFGLDQIDRSLFILADVRRSEGKLTLKYSFSPGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2U0</accession>
    <name>A0A232F2U0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001140">
        <property type="protein sequence ID" value="OXU25005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2U0"/>
    <dbReference type="STRING" id="543379.A0A232F2U0"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="12152" checksum="B9B55376BC4166A7" modified="2017-10-25" version="1">MGHKCILAKRSPVFAAMFQTQMKETQENEVMIEDVEHDVFVEMLRFIYSGKVHHLDRIARELLPTAESEEALRNRAVQTTVCRERTGDLGAKVFFINVTISSINRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2X1</accession>
    <name>A0A232F2X1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001117">
        <property type="protein sequence ID" value="OXU25081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2X1"/>
    <dbReference type="OrthoDB" id="10460776at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="12318" checksum="8D285F7B4C69A643" modified="2017-10-25" version="1">MKDFILNCVNYYKAKEGHGFDERQKRYTIENDEIYLGEIKSVQVLEWDMINLDRPPIFLVQTALHLWDITEFANRAFEIHDDMKNIPGRSTVKLIEINLLRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Z1</accession>
    <name>A0A232F2Z1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator complex subunit Med12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001176">
        <property type="protein sequence ID" value="OXU24858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2Z1"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="785"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1320"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1851"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2257"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1338"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1873"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1895"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1939"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1991"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2016"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2071"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2257"/>
            <end position="2281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2308" mass="255952" checksum="D73F2710E7BFD8B1" modified="2017-10-25" version="1">MGILYEKRPLKRPRLGPPDVYPQEPKQKEDELTPNNVKHGFTTSLQLSDEHGTARNCNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKIGIEAWFKDLSGCKPLVSLAKKAPNFNKKEEIFTMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQEYYHLGHGTSNSNSNSNPSTTANGTTNSSSTGSGGATPNGTSSSSQSVTTNGLVNTQPSTPNSNSNSGTQCASGTMMNEDHKLALKQWHYCSQLAKYMFEEGLLDRQELLQWILELLDKMKSAPADDGILKLLLPLALQYLEEFVQSELLARRLAYLCCRKIAHMCNNVDTSYCPSSPSVAAVNATSSNKSEMNGNKDGAVPQPQTAPVVNQLNAVFNDYLNCPHHRDVLYGLSTIIQVITLECPTALVWNNVGEGKSISVLNGSPLDHLPCPPAALPSPPARAADPTRRQLKIAQENIRARSQAAESRWSCDKWQQSSAGMTTTKVLATLDALDRHSFDRMDANNSLDTLYSKIFTSPSKDSNAAAAISSNTLTPPSSANPASSDREGANSKTEYNPQQDAPIVEILCEWAVSAERWGEHRAMAVAKLLEKRQAEASGENNDNDDKDSVCSNGNGPPALPIFQPLLMKFLDVDAPVLDTSSAQSKVQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPAASKASTPSNRDPMDEDSLFPGIDLKPTKLDPQDHMRSTNDYDDSKIDDDLDKILQDIKDVQQNSMDAPDSPKESDALGGHGAHDAGLESKTSSSPSRHLLYTMHFPLPQDETCSQHDCNQRHVLLFGVGRVRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAITQKFQNLSYFDQHVVTWQCATQVVDMLNTFVTGSSYLPVQEHVAFLFDLMELALNIYGLIDICIQILKELPEVEAQLDVRKSTLVRNYTTNLSLYIVGVLRRYHCCLLLSPEQTTVVFSLLCKMVAHVSNPSDCSSAERCVLAHLYDLYSNCSLLKTKPHSSEGFNNANPKIRAAYYTALTLTPSNHLYNSQFMVDVLNNPRRGVKIEPQWARQLNETPANRYSFVCNAIVTVCSETDNDKLNDIAITCAELTACCNALNTEWLGVLSALCCSSNSSANYNDVQNQVDVQDLSIHNSLAVFTSILIARHCFSLEDFVRHIAIPSLGKAFNDGRGDADTDAEAGARLTCHLLLRLFKTVECPQPSLYSVGTSPHPLPTGNQRSYSIKLSCDRHLLAAAHNNICVGPLIAVLKAILVVGDATAGKQPPKKPDTQMPHAKGGPGSVGGSAPGELSISTSDILGGSDDLGLDLGMSSSSSSVGMTTENVKGLSDFAQHVLRQICSQEWVLERCLQNPEELCQDDMLLDSMLTPRQAQRLLHMICYPDTPADAFLDQKTHITNILENLEQWSLRMSWLDLQLMYKQFPPSSADLSQWLDTVAKAAIDVFQLNNVSGKPDKRSDSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTTGRERRSKSPSMFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFCTSSKEEKSISSDDPKAREILQDALQLRFSLVGGVFDTIQRNITVTNDWAMLLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKYYQNLMKKLKKELGDRNNQSIQFVRQLLPLPKITMEVITCEQVGCITDTKGNKIAGFNSIDKKQGLQVYNAQRVSAWELLEGHKNPAPLSWAWFRAVRLERKPLTYQNAHKLLRYHTHSQTRPASYYLEPPPLPPEDLEPDKKELETCKADTPMSIDSPGRMMAAMGGIGKGKALKPSKRHRRNKNGPATPTNCMQPQQMPPQQQGPTPMQQQMAYGGQQPPQLPQQPGMFPNQPPQPQQQQQQPQPQQQQWYPNQQAPHPAAAQQYAPYGQQMAPNQVTGPRYDRPGPALNQSQSKQALTNMLRMRLPTNQFMSGQQQQQQQQPQPQQQQPGPPVPNATQPNVGGPGAFQGMRNQFIRQQLRAHGQQHAPPGMQQQPGLFPPQQQQQQPQNMYANMQQGMNQNYAGYGGQQMIPQQQQQQQPNMMAQQQNMFQNQQQMMGAQNQQQMMNAQSQQQMMGAQRNQEYLQQQRMQQGAARPPYMQQQAPNVTMNTMGPMASGVQNQPAPPYRQAGGKPGAVNVGGVGQANVGLQPNQHMQPQQMSALNQQRMRQILAMQQQQQQQAQQQQQAQQQAGNAGQQATPQLVAHLQRNMNQAPQHPYQHQPPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3S3</accession>
    <name>A0A232F3S3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001031">
        <property type="protein sequence ID" value="OXU25414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3S3"/>
    <dbReference type="OrthoDB" id="7698426at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="76" mass="8490" checksum="29650417D35CE3A9" modified="2017-10-25" version="1">MVLNINTNNVGERILAEFEELFSDTPGLYNRREITLHVHPGTEPVALGATHGGPKYSQLDLAHAYMQIQVAEESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F446</accession>
    <name>A0A232F446_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000999">
        <property type="protein sequence ID" value="OXU25544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F446"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="53" mass="6323" checksum="98BC1C520D211381" modified="2017-10-25" version="1">MTLVFVETRCQHESKSHARTFHEDAARTRDWRKSHASTVYGQEKHYIQQLALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4U4</accession>
    <name>A0A232F4U4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sperm-associated antigen 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000980">
        <property type="protein sequence ID" value="OXU25632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4U4"/>
    <dbReference type="STRING" id="543379.A0A232F4U4"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="59557" checksum="22B855600039A1EF" modified="2017-10-25" version="1">MTARIISQVFDHYQKARMQFVQTVTDLASRPHNIEYLDNAGVLDLLCPLLWDVTPTIQQLTAIALGRLANHDVKIARAILNKNILPRILKKIDKQTEFFKKAASFLLRALVKHTPEMATRVVSEGGLEAMTLCLEDFNPGVKEAAAWAVGYISRHNKCLAQAAVDSGRAVPLLVLCLQESDVCLKQISTSALCDISKQTAELAQVVVDAGAIPLLAKAVSNQDPKLKVALRQALTALGCIAKHSMELTEFVVEAQVFPEVLYHLQHSDENVAKAAATLTKEVCKHTIQLAQFVSNTGGIEFLVEAIRTRKTSTRLQAIMALGYIAGHSDELATAIIEMKGVHQLVTVLSIEQENHILSITIWALGQIGKHSPEHAKAIADTNVFTCILALYTNPTNSEDLRNKCKASLKQILQKCMHIEALEPLLHDAPPNILKYILGQFSKILPNDARARRLFVTTGGLKKVQEIQADPSSTLSEYITIINCCFPEEIVRYYSPGYPDSLLEAVEQYQPNCSFNESKCESLSNEQSNSSISLDDKGAVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4U7</accession>
    <name>A0A232F4U7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_010087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000930">
        <property type="protein sequence ID" value="OXU25856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4U7"/>
    <dbReference type="STRING" id="543379.A0A232F4U7"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="454" mass="52998" checksum="4E34988799CC6C46" modified="2017-10-25" version="1">MTSTDPRDDANTRERTDIGSFGVAVPKNSREPPDKEYCDVRKRKSTLANILETLLKLESKVLIFNTSSPLKIVLDHNNQTCLILIMKSSRRFWNEFKIYKFVLWPCGVWPSEKRSLIDIFFYLVATISQIFIATLVSEEIYGTCGTPADLLDYYAFFVCFIMSFIKLLCMRLHFIKMYRNCLYAQKNWTKVVDTNVLKIMQRYANVAKKFYHVQMFAAICVVSLYVVNPFILPRTDASNLPIQTVCSFRNLTDWEYVIVYVVQSMSLLYLAFGFIGVDVFFFGIVMHLCAQLKILQIEFNTVGKLTWRLDNIRLMALYSKKHYQLIMLANDLKTTFSATFFIALKINNKFLALKSTQAFPILFLEVFLYCYAGQLLQYEFSNITNSIYNSRWYALPPKLRQYYLLFGMTAGNKAFRLTAGQLVNVDMRLFIYFVKTIFSFFSLLLLMFDKRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5G1</accession>
    <name>A0A232F5G1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000961">
        <property type="protein sequence ID" value="OXU25718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5G1"/>
    <dbReference type="STRING" id="543379.A0A232F5G1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000003">
        <property type="entry name" value="NAD kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000013">
        <property type="entry name" value="NAD kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="494" mass="55656" checksum="D6B678052DF4FE71" modified="2017-10-25" version="1">MEIIMRERARRCSVSCELLNGGSWRDIPEQQQNHHHQQHSQQQQHCQLLLEDKDPEFRRRKRSGTWPDWYAAANQHVFMDQVSPLRDTPKDGDPETSFDFEQLSLAEIRQNRVLRRTRSLNAPSPIQQFGPCGRIMKNSAMVMTIQDPASQRLTWYKPPLTVLVIKKVRDSSVLPPFVQLVTWLIEEKRMVVFVEASVLEDPALARDHRFQGVRDRLQTFRDGTDDLQDRIDFIVCLGGDGTLLYASLLFQQSVPPVMAFHLGSLGFLTPFEFDNFQEQVTNVLEGHAALTLRSRLRCIIMRKGEEGQPAKPPTNLLVLNEVVVDRGPSPYLSNIDLFIDGKHVTSVQGDGLIVSTPTGSTAYAVAAGASMIHPSVPAIMITPICPHSLSFRPIVVPAGVELKIMANSKARSTAYVSFDGRNQQELRVGDSLRVTTSIYPVPSICAADQITDWFDSLAECLHWNVRKKQKHLDELSDLTHSSSNDTLDSLDRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5G4</accession>
    <name>A0A232F5G4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_012417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. ABHD17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000993">
        <property type="protein sequence ID" value="OXU25577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5G4"/>
    <dbReference type="STRING" id="543379.A0A232F5G4"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000008">
        <property type="entry name" value="Alpha/beta hydrolase domain-containing protein 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="548"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="623"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="759" mass="81949" checksum="8D2020E17A635E0B" modified="2017-10-25" version="1">MMNGLSLSELCCLFCCPPCPSRIAAKLAFLPPEPTYSFIEDEGSKYTISLSERAEWQYSEREKESVEGFYARTSRGNRIACLFVRCSATARFTILFSHGNAVDLGQMSSFYLGLGSRINCNIFSYDYSGYGVSGGKPSEKNLYADIDAAWHALRTRYGISPENIILYGQSIGTVPTVDLASRYEVGAVVLHSPLMSGMRVAFPNTKRTWFFDAFPSIDKVPKVTSPVLVIHGTDDEVINFSHGLAIYERCPRAVEPLWVEGAGHNDVELYNQYLERLKQFVSVELGQGGGGGGGAAVQQANSTSKQQQPAQDQQQYRQDSLSTGSSISSTTSSPSSARAVRISPSVKKLNLNPRPINGDTAPLNDEIFFFSEERLRSKPEIDSDKKEKSGNKADTKQSLDEPKKSPNANATKKPLSPCESKERSLDYPSTRLANQKSNARAKSCITEKSSLVKIQLENCCKESAKSPNEPQENVSADKEKTSVSQPDHNSVDLLPDGESAAIKKSDTTTKCSKKSPDDHHEQSQNITANVKKPIRDIKNKFTWCGSCKSTKSASSVGQGSKTAAAAATAVANKSKRTSSTSPLKKLSRSSLTADSTENNKITLNLSKYSPCASRLAASSKILSSDSLGATSPESPLHVARSKSPVQPSLSLNIQQETRRPANKTGSRVVGSGAQPARSKSVGGGPDSCVTSPASDALSCSPPDTEILSLEDVSTGNSKQQQQQASALDDQSTPRAVAPASAIELGLDRERWNASYRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F640</accession>
    <name>A0A232F640_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Regulator of telomere elongation helicase 1 homolog</fullName>
            <ecNumber evidence="17">5.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_015750</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">A probable ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.-" evidence="17"/>
    <dbReference type="EMBL" id="NNAY01000911">
        <property type="protein sequence ID" value="OXU25960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F640"/>
    <dbReference type="STRING" id="543379.A0A232F640"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17970">
        <property type="entry name" value="DEAHc_FancJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000431">
        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03065">
        <property type="entry name" value="RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030845">
        <property type="entry name" value="RTEL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23116">
        <property type="entry name" value="HHD_RTEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0408">Iron</keyword>
    <keyword evidence="10 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="883"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU25960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125913" checksum="96B01B24DD7FC4E5" modified="2017-10-25" version="1">MTEVTLNGVVIKFPFKPYQVQEDYMKKVIECLQEGKNGVLESPTGTGKTLSLLCSSLGWLMIKKAQIQIQVQSLGALDQVGSGNSYLDQFAKSLDKGGGKSTNQAPTNTFGWSMPKIIYASRTHSQLSQAMQELKRTSYRHVSVTVLGSRDQLCIHPEVAKEQNTSNKIHMCQAKIRARNCFYYNNVELRKDDPTIKDNILDIEDLVKTGQKLKCCPYFLSKELKQNADIIFMPYNYLLDPKTRKNQGIELQNNVVLLDEAHNVEKMCEEAASLQISSTDIAVCIDEITHVMKDMANETNDQDFLSEGSNAAQKDFSAEDLCILKAMFLELEKAIDSIQITKRDEGDTYPGGYIFEILEKADITQGKELLVIDKLDKIVTYLTTVSASSFTRKGNALQKFSDLLRVVFAGSTNNKYREKIKQCYKVYIQAEPAKKSFKNDAWETKKITKTDGKLISYWCFSPGFGMQQLLDQGVRSVILTSGTLSPLKPFISEIGIEIGAQLENPHIVSNKQICVGIISNGYDGCSLNSSYNTRNDPKYIASLGETIKIFSCILPHGMLIFFPSYPIMKKCQEEWQKMGKWSQIEASKPIFVEPQSKEGFNNVMTEYYKKIHDPAHKGAIFMAVCRGKVSEGLDFANANGRAVLITGLPFPPLKDPRVILKQRYLEENRASGKESLSGQQWYQLEASRAVNQAIGRIIRHKNDYGAILLCDCRFDNPSFKQHLSSWIRPHIKKFQDFRMVVKELREFFRYTTAHLPQPAIGASEMSSMALPSVPAEFDTSNTRIVKSNSKTLVTTPEEKQNENFDLNAYKIKGNTEKEKKTDQSPKDFGSLFETKSKTVVNFSTCKLQTTANTFKEVSPSEEPNAKRRKLKIKPVQFSVEMPVVSEPSTSCTEPGIKTESQRPRVDGPEDSAAARQQQGKKYIQQVKGSVSPDDFNTFKILISKYNKGICLDELIAALEKLFLIDYKLKHLYIGFRNFLRKDHIKAFDAQTKLMESLDDYLLDKPVLQSESQEVNVNKPEDTVASRQEQGKKYIQQVRESISPEEYSIFKRLMNSYKNDANFDELVNGLEKLFVIDHKLKHLFIGFRSFLKKDHTKSFDSHIHAMEGSSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F645</accession>
    <name>A0A232F645_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000919">
        <property type="protein sequence ID" value="OXU25909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F645"/>
    <dbReference type="STRING" id="543379.A0A232F645"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012466573" description="C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="14326" checksum="1A334E36EE7CFDDB" modified="2017-10-25" version="1">MNSHFCKSYLFTVLNTFLSFAQHPQDLEPEYDPLQMPTVLAIPQDVRRFPRTRRRAANFSCVNCNKSYTAKRSLSRHIKHECGGQKRFHCHLCVAKYTQNTTLRRHLTQRHNIFIPPKNMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6I6</accession>
    <name>A0A232F6I6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000792">
        <property type="protein sequence ID" value="OXU26476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6I6"/>
    <dbReference type="STRING" id="543379.A0A232F6I6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="490" mass="56614" checksum="A76FE3B87C76D356" modified="2017-10-25" version="1">MPYQALDEFAKMDENKIKRIYSALVNCEWNELGRAYVRILSEPFETEENLSLELFKAKTPLALIVGLGNVDLVRMLLDIGANANEPATGNFLALHMACYKGNLKMAEVLLQGKADPNALDSHKRSPLKALFHAIHKKWFKVDIKECYLMTRMLVSYGAKLGDTDMDTMIYAIEYTNVAIVKLLVKKANGDLKYRPLNMSDYCLHVAVVKGQPGILEYIIEEVKGSLIISDRSKAYTARYQAFGRRHTVRTSKFKAIDALNLHRETPLMTAYKVENYKAVKMLLKAGATFYETFENLIAGTRKPELAELYFERGYDVLALENRKLLHQVVLDNNSWLEDIVAEICRRKFLGYSINSCLKVLSRSEWANYLLEDCCNQLKLMRKIKFYKNVSFYDVLTAHRSTLTKYAETSELVEAFFNTKCQRSFPNYCARMRRRFIDVIPRNFLINLSSYQVSNTVKRPEMYEIIQHELMNYMETDDFFKFLACCAETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6L1</accession>
    <name>A0A232F6L1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000875">
        <property type="protein sequence ID" value="OXU26110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6L1"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF42">
        <property type="entry name" value="ODORANT RECEPTOR 83A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="421" mass="48573" checksum="59C7618C1815543C" modified="2017-10-25" version="1">MEETSAFYRRIRRIQMRVLRLAGLVPFENRTLRFAGTILMSIYVNFAFTAVSSVYIWAFVEDCLNKRFNPDITSELFSFVGFHFRFMYIFSRRRKLGKMLGYAESLWERVRSEEKVHVRLFVRKVSKLSVCYSGIILTTITLYVLSSQLPQLTAAATNETVHRVLPYPFYVDVQSSPRYEILLGAQIVCLLTVTQTSVCVDTAIAFLIMIACGHFRLIQVRLGVIARHIEENEDKRRSQRSVAKDGEVIELEVEAEMDEEDFERTDERVRERVKELVMHHQEILSFCDDIKNLSSEIFMIELISTTYNLSLIGILLAGNMPLAEKFKFAPVLFILTTQLFVCQYPPDLLLQESEAVANAAYFVPPFRRDRRRIDRILLSLLARSQTPYQLLAGGQIPLSIESFGNMIRGAVSFFTVLRSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6U5</accession>
    <name>A0A232F6U5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_001256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000827">
        <property type="protein sequence ID" value="OXU26302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6U5"/>
    <dbReference type="STRING" id="543379.A0A232F6U5"/>
    <dbReference type="OrthoDB" id="1903104at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15619">
        <property type="entry name" value="PHD1_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15530">
        <property type="entry name" value="PHD2_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025750">
        <property type="entry name" value="DPF1-3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF5">
        <property type="entry name" value="D4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14051">
        <property type="entry name" value="DPF1-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="435"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="492"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="547" mass="59630" checksum="8E661983226C80E7" modified="2017-10-25" version="1">MTAVSAPPSSVHSIIQVVNEANLSKIESFFNDSAYREAIENSSTYNSRLCRERRLRMPFLDSQTGVAQNHSALFMSARERLPGLQHGQIYTYPSKRWRKKRRQYLMHYFHPKRVIRGDVEDGVECIENSGIPGANDDSKDSIPLKDEHSKDAWFYDEQDMLDMDPYEEPDPDSDFDYEESYSSKRKRRKPRGGGHHPTRSHPPATDSPTGKRTKGGGRGRKKVNYDASDSDKPFVCDRGTRRGRQSTATATSSASSTSGPSAAAAASSASVSSISAVVVGPTPLLGSAVAAVAVATAPAPSSFQVSNGLVPAVVASQQQQQQQQQQQQQQHQPTAESSCAAAPASPTVSAIGQNQNSKDEQLHRPPAAQSPMNNTGSSPKPTGMDHQQNSPMSQPSSMLPGQPGQPGGQQQQHHQGNHHHAGGMDGKKAKPAQPSPYCDFCLGDARENKKTGGSEELVSCSDCGRSGHPTCLQFTANMIVSVRKYRWQCIECKCCSICGTSDNDDQLLFCDDCDRGYHMYCLSPPLTSPPEGSWSCRLCLAEFHRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F725</accession>
    <name>A0A232F725_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000755">
        <property type="protein sequence ID" value="OXU26656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F725"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9573" checksum="65DBAC049FF1AFCD" modified="2017-10-25" version="1">MIHKKCLDSCFVWWDPDDPAQHRRRPGFFRWFRALQSSVTLAHSWAGSKGSLKCVDAGRRIPRKSWSSIFSTTRSDLRQNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F793</accession>
    <name>A0A232F793_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000815">
        <property type="protein sequence ID" value="OXU26360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F793"/>
    <dbReference type="STRING" id="543379.A0A232F793"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12260">
        <property type="entry name" value="RRM2_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12259">
        <property type="entry name" value="RRM_SRSF11_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000084">
        <property type="entry name" value="Serine/arginine-rich splicing factor 11 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034192">
        <property type="entry name" value="SREK1_RRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="173"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="523" mass="58219" checksum="232891CFB14ED5C9" modified="2017-10-25" version="1">MAVGSTTKVVQVTNIAPQATKDQMQTLFGYLGKIEDIRLYPTIRDVAVPVQSRICYIKFHDTNHVAVAQHMTNTVFIDRALIVIPYQNGDIPDEQRALELTNNGTVVPAIRTFLPGLYPSEPKLPPNVVNAIEGIPPNHVITTMDPKLEANGLPLYPHLPGHLDSRKIEEIRRTLVVGNLDASTTDQQLIEFFGNHNVEVKYTRLCTRDSDTDHYALVEFSEQASIVPALQLNGQMLNDRPIKMGHSVQAIMKPEAKSNEAAQKEIEEAMSRVKEAHNLISATIDPMIGMLSKDKRSRSGSRGRGKSSQFYDIPGQDHVDVQGARVLASGLAHVTDVLALVIVGDHAPGHASALAQGSDARSPDHVAEVPLGQDIALDQEIEDQDLDGRGLDPEIARKSHQLVLCLYNSIKRRSRSHSRSKRSKSRSRKSRSKSKSRSSKSKYSEKSRDKDKERNKDKSESNGKKSSSSKDDREKNEDTGRSEKKSRDKEKRAAEKEEKRSEEKSRASSEFSDKEKDKPDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7J0</accession>
    <name>A0A232F7J0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000837">
        <property type="protein sequence ID" value="OXU26257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7J0"/>
    <dbReference type="STRING" id="543379.A0A232F7J0"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="206" mass="23142" checksum="B9B9E83A9C492FB8" modified="2017-10-25" version="1">MASLVADYGTSSGSESERDELSDSESSKDEAEEEENIENEDEDNQKDIASNKKLPLPTPDFNGAPTMKTSVFKNPFVEAEKAKSAILEKHVKMTPTLDDTKMINGRKICWNYRKGRCRFGHNCTFAHDSDLHRSAAELEAMRAPQETIICQTQYNGQVGINDDDEVDQENNQTQKRKKRPGLSQTLVPGKKVLKMYKAQQAKAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7Y1</accession>
    <name>A0A232F7Y1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_006258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01000772">
        <property type="protein sequence ID" value="OXU26600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7Y1"/>
    <dbReference type="STRING" id="543379.A0A232F7Y1"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="183"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU26600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="327" mass="35301" checksum="F0AA2C3437BF4BD8" modified="2017-10-25" version="1">MILCKKFVCRSKTFFCSIASKMSTNAEDQFFQAAKKLVPVLSNAKHKGQAGRIGIVGGSLEYSGAPFFAGMSALRTGADLVHIFCCKEASIPIKSFSPELIVHPVLDDNNALSQIEPWLERLHVILIGPGLGRDQKVLNTVGKLIEVCRGVSKPLVIDADGLFLVGQNTQLIKNYPSVVLTPNSMEFTRLVKAFLNKTVEPEKVVDGKLLKELAQTIGEKVVILHKGSTDVIGDGRAVSTNISCSEAGSFRRCGGQGDLLSGALSTFTCWSQGHEHSEPTPQMLACYAASRLVRECNSAAFKIGGRGMLASDMLHQVAPTFAKLYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F859</accession>
    <name>A0A232F859_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000679">
        <property type="protein sequence ID" value="OXU27024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F859"/>
    <dbReference type="STRING" id="543379.A0A232F859"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000423">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="479" mass="52924" checksum="65382EC4112D50CB" modified="2017-10-25" version="1">MRMCLPLTIPNMVKPTKHISTSILQADDTCPGPTYNATLQHHEMRNTTGTYDWSEYTQGIILGSFYWGYVLSHVPGGIIAERFGGKHTLGVGIFTTALFTLLTPWAIDWGGATALIFLRVVMGLCEGVTQPAVSALLSQWIPAEERSKISSFVFMGATVGLLATSLGLSPIMEHLGWPGFYYIFGGLGVVWYVLWCVLCYSSPRDHPFISKEEAKMLNEKLSQHTHADPPPVPWRHLLTSAPFWALVIVTIGRDWNGYTMMADMPKFLINVLKFSESEVGLLFLSMNVSMLISCSLFSWMSDWLIEKNYMSITNVRKLMASISLTVHGVFGVVSVYVGCNKFQYFAVSFVSTFTSGAGFPGVKANVLDLSPNYAGTVMAVSHGLAGLCGFGGPYVVGILVPNQSLTEWILVFWIIFAVTVVTNVVFVLFGSGEVQEWNNPNFERSKKKSKMIEMQEVEKLLTVKKVQLAVAIDEGINPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F934</accession>
    <name>A0A232F934_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000716">
        <property type="protein sequence ID" value="OXU26827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F934"/>
    <dbReference type="STRING" id="543379.A0A232F934"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000031">
        <property type="entry name" value="Heterochromatin protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU26827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9355" checksum="529F577368240191" modified="2017-10-25" version="1">MNKEKKIDNKGAKPHGFKRQLEADKIIGATESNGELMFLMKWKGTEETDLVSAREANVLCPQVVIQFYEDRLIWQTAKSTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9C2</accession>
    <name>A0A232F9C2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_013569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000636">
        <property type="protein sequence ID" value="OXU27265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9C2"/>
    <dbReference type="STRING" id="543379.A0A232F9C2"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF53">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 11E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU27265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="288" mass="31924" checksum="56A3027F8E816256" modified="2017-10-25" version="1" fragment="single">PRPISKKKKKIQSSTNLHPFNAMSNPSESSVDDRLNPLAPSTSNSNSSVPRTRSPKCARCRNHGIVSGLKGHKRSCAWKDCRCACCLLVVERQRVMAAQVALRRQQQAQDQLQASGALEDTAGESVSNVVARDDGEHQASRAAAGGLHRQRAMAAYQRRLRNFQRHRLQLTQTRISVTQDLHILNALPSMPDHSHLAGSFTITESQDSNSSHQRQQLQDDTPMDFRSICPSYSQIPWFSCFSPDATTTSSSVQQHPNELSTSLFGTNDSQTEKKSKISFSVESIIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9W5</accession>
    <name>A0A232F9W5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_005722</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000665">
        <property type="protein sequence ID" value="OXU27107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9W5"/>
    <dbReference type="STRING" id="543379.A0A232F9W5"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11864">
        <property type="entry name" value="SH3_PEX13_eumet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="269"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU27107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="396" mass="43575" checksum="D8AD47EFE3315728" modified="2017-10-25" version="1">MMNQQRVNVIGPTQFRNAPTVVDGIPQPMGISGVSAMGPPPVPPRRPVSSYSSYGPLGSSMGGYGYGSGWNSMGMSRYGGYGMGYGSSMYGPSYSMYGQNQWGGGPSGDVENRFVQYAEESTRPAFQSIEAMVHTFSSVTMMLESTFFAMTSSFRAILGVADNMGKLRSMLKQLLSSFALVRFMKWLYLRVKYTLGIRSQDASSEMLWRETISEVMNGSPEQSGTTSWPIFLFLSILFATPYLIHRLISNAKNINVDVNNPKDWLQNKEPVYTATALYDFTPASSEELALKTGQKVWLAPQSLQPKNLQGWWRATDSINVGLIPSTYVTVVGQLKKKSESSQSQTSNVYQPSASNATSSVIPESTESQDVSDFEKDKGESLIKSNIDIFEAKNKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA44</accession>
    <name>A0A232FA44_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000597">
        <property type="protein sequence ID" value="OXU27492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA44"/>
    <dbReference type="STRING" id="543379.A0A232FA44"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="68"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="506"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="603" mass="67632" checksum="152967A4890F15A7" modified="2017-10-25" version="1">MLWRHRIVRFAVRQNVGSDSRHAAIVLQKRHHSVSTAAAIPLPDKPKLSYLRNPGTRPLLETTIGKLLETAAGRWPERDCVISIHQSSRLTYGELLLRADKLAAGLKKLGLRKGDRIGIWGPNEIEWLIGYMGAARAGLIVAGINPYYQLGELHYCLKKIGAKAVLAPESYRTQRYAEMLLTVKKSLPMLDHIIVYADDHVTGTRRFRDVESLADRKEVEMIKEEQVEISPYNGTNIQFTSGTTGNPKAVLLSHRGLVNNSRQAVTRLDTDGRKICLNVPYFHAFGMVMGIVGPLHAGSTVVLESPTFNPIKSIDAILAEKCSVSFGTPTMWTNMIDVQTRTGAKIDTLYTGSTGGATASPDLYKRVRECLRMERIKRDEVNFVPSFQSIYGLTESTAIVNQALPEEDNQLTETTIGYISDHLEIKIVDEKGETVPFGTPGELCTRGYSTMLGYWDDEENTRKAIMEDEWLKTGDQYILREDGYGIIVGRLKDMIIRGGENIYPKEIEHFLESHPSILEVHAFGVHDDVYGEEMCACVRLRSGAKISVEDVVNYAKGKIAKFKIPRYIVFREEFPKTTSGKIQKYKLRQEMEDQGIVPKAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAI7</accession>
    <name>A0A232FAI7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000599">
        <property type="protein sequence ID" value="OXU27469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAI7"/>
    <dbReference type="OrthoDB" id="7676481at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="226" mass="26351" checksum="EFABF5B1414E1DB6" modified="2017-10-25" version="1">MESKTQVKNEPQEQSDNDAQKKENTSNNTEDSPQVKNDAIIKTKNLPSETTILSPPPIPLAVNNIFFELFYDGPYDLTLSNRLWGIHRVPPPNRAIVLSEITFSLFNVSMSPSYKKQVIFTEQLKFKAFVLDKLVVEKTLDYENTREDFEQSFAEIVNMIVCKGGPNIEDNQDILLRCAYKDYYSNRWRHKSCTIIIEKGEEVCRPCSYLDKYFQEWIKYNLKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC74</accession>
    <name>A0A232FC74_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Allantoate amidinohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000487">
        <property type="protein sequence ID" value="OXU28049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC74"/>
    <dbReference type="STRING" id="543379.A0A232FC74"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="3">
        <location>
            <begin position="209"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="374" mass="42232" checksum="BC139D2C18BC22FD" modified="2017-10-25" version="1">MKMLPDFVEGVQVNSEENGGTILFATDDFFAVAENLLKSEEPVWKEDYTEFGKWMDGWETRRKRIAGHDWAVIALGKPSILSGICVDTAFFTGNYAPRFSLQGACLFQTAKGIQNRRNKMGSAATAEDLEKASELQSENWETIMPMTSLKSGNLNTRKHFFELDTGDRVYTHLRLNIFPDGGVARLRVYGENSKSLPNNRLHMMQPLRGKCVDFSNAHFGHPDTLLVPGPPKGMHDAWETARRLDRPPEIQVDDSGFMQINGEEWATLLLEKAVYVHYIEVDTRFFKGNCPDNVKIEGTYVEPGQDLKSASWDIILSRTKLMPNQSNGLNHPFIEFINRPINHVKVIIAPDGGIARVRIYGSECDSLKQHKPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDG8</accession>
    <name>A0A232FDG8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000420">
        <property type="protein sequence ID" value="OXU28523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDG8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="11372" checksum="F493941F58F3409D" modified="2017-10-25" version="1">MNNLTSENKRAIEQIANKTINTWKLKTESKQIINTTTTEDKVFKSTLGNAEKQNKQLMLAENCENCDLPKPSITKHIRFDKQEQKVEDDSIKHIKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE95</accession>
    <name>A0A232FE95_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000340">
        <property type="protein sequence ID" value="OXU29081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE95"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="229" mass="25973" checksum="14D9875E83412FC0" modified="2017-10-25" version="1">MMALNEQKKELVGSGGGSGVKNEAQYKNTQMTIKAQLDSSRGFAVQSNGGIDLVIDLQFFKDHKGLVVPKKVGLAVLNLDTTAYWIITPTFPLEKWYKTMHNICRRANKVYYCIHHFIKRCAFQYTCALNNACKLKLWVNLLGTGGDIISTAERPFSPPYYLYKNKFTKYPPKVTKNKSSCSRHSSLSKGISSFGGKKNIRRRKWLDKKHSTIAKFRTVRPPSIAVIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEB1</accession>
    <name>A0A232FEB1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000347">
        <property type="protein sequence ID" value="OXU29025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEB1"/>
    <dbReference type="STRING" id="543379.A0A232FEB1"/>
    <dbReference type="OrthoDB" id="4777606at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042477">
        <property type="entry name" value="HMGXB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584:SF1">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="205"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="205"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="412" mass="46002" checksum="1B233D06149D2A72" modified="2017-10-25" version="1">MDSFVTPKREGNELEVTGISRSGRVRKKSSKLMDFESSSNITETKIKRPKMQSPQDQSKKKKPTTTDGQPLSPVPQVTHTVHVAQIHHPPPNKITISPPKKSPKLPPTPMQQKKKKIESSSDYETQSQSTNSESEDDVVSKKLHIAEFSSKDMSLDALEPAEDEITTPKKKPPYPKKPKKTVTIAPSVKPDIKPKPTKPELAQKPKPRYTAYMLWSKEMRQQLLKESPNMDFTSISKRLGELWATVPNMEKYNWSNRAKRLAEKNQMSPPKKFITKSNIMKSSSSDSPKKKTDVIRISDLKKLPPQSIRSGKDATRDPTKEMKIFRAIELQPIDVAAYLKLLGESLTVIGERLKEHNGQITVSGSLSVLLDSLLCALGSLMCLTQQVPAIGTQNSASLSKTLENIAYIMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEJ6</accession>
    <name>A0A232FEJ6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000330">
        <property type="protein sequence ID" value="OXU29176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEJ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="9031" checksum="3979A1986B2E59A0" modified="2017-10-25" version="1" fragment="single">NNDGLSIRTLVKGLRKLDNLVTFKAELQSVNKSAEQRVFFNMRSFRLASLEVCTASQIMLHQKKWKVMLVLILPNRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FES8</accession>
    <name>A0A232FES8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_015168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000342">
        <property type="protein sequence ID" value="OXU29053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FES8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="223" mass="25942" checksum="9BBFCCC5AC2D5C7D" modified="2017-10-25" version="1">MSYAKRSDLWGFDRDWDDTLEESSKPNSLPLLELTRGDKIYYKHSKRVRGIRYDGLDFVPLNPKLDPPPHRCFSCWERGHLSRTCMNPLISLFCRNCGRRDVDLEDCPRCSRAHRRESAKKDTAEALQEAKIKTEAKIPEKKSRAAAETLLDVSLLVNEGSVASDEDDAPRRSLETIQEEFEFDFTHDMISDVKILMEAVKHLSVKTQDRVLRQWLTERQKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF24</accession>
    <name>A0A232FF24_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_006113</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000310">
        <property type="protein sequence ID" value="OXU29302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FF24"/>
    <dbReference type="OrthoDB" id="6018565at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045169">
        <property type="term" value="C:fusome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045170">
        <property type="term" value="C:spectrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042062">
        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11808">
        <property type="entry name" value="SH3_Alpha_Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000154">
        <property type="entry name" value="Alpha spectrin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000037">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000272">
        <property type="entry name" value="Spectrin alpha chain, erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000020">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000006">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000017">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000035">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000043">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000078">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000340">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035825">
        <property type="entry name" value="Alpha_Spectrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="972"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="2286"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="2329"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1220"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1662"/>
            <end position="1696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU29302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2451" mass="281989" checksum="34622FE6915CC58D" modified="2017-10-25" version="1">MDQQITPKEVKILENPEDIQERREQVLGRYANFKSEARSKRDKLEDSRRFQYFKRDADELEGWIYEKLQAASDESYKDPTNLQAKIQKHQAFEAEVAAHSNAIVLLDNTGSEMIAQHHFASDIIRKRLEELHRLWELLLNRLADKGLKLQQALVLVQFIRHCDEVMFWIHDKEVFVTTDEFGQDLEHVEVLQRKFDEFQKDMTSQEYRVTEVNELADKLLLDAHPERDTILRRKEELNESWQRLKQLAILRQEKLFGAHEIQRFNRDADETMAWIGEKDAVLSSDDFGRDLASVQLLQRTHENIERDLAALEDKVATLSTEADRLAGIHQAEHSQQIQSKRAEILQSWESLTAKAKERRFKLDESYYLHRFLADYRDLVSWMNNMRAIISADELAKDVAGAEALLERHQEHKGEIDARADSFDSTGLAGSKLLERQHYAASEVAIKLESLAADKASLLELWEKRRILYEQCMDLQLFYRDTEQADAWMAKQEAFLANEDLGDSLDSVEALIKKHEDFDKSLAAQEEKIKALDEFASKLIEGEHYAADEVAQRRQALLQRRSALLEKSALRRRALEDAYKLQQFERDCDETKGWVNEKLKFATDDSYLDPTNLNGKLQKHQNFEQELQANKTRMQEMVAQGQELIEAEHYARERIQSRIKEIVELWESLTEATEKKGNKLQEAAQQQQFNRTVEDVELWLSEVEGQLLSEDYGKDLTSVQNLQKKHALLEADVGSHQERIASIAQAAEQFVAGGHFDADNIRQKQQQLQGRYSALEQPMQMRKQRLLDSLQVQQLFRDVEDEEAWIREKEPVAASTNRGRDLIGVQNLQKKHQAVLAEINNHEPRVAAVCAAGSRMLSDGHFAAEEISQRLASLDEHWGQLKEKARQRKNDLDDSLQAHQYFADANEAESWMKEKRPIVMNADYGKDEDSSEALLKKHEALVSDLEAFASTIAALKEQAAACRQQETPAVDVAGKECVVALYDYTEKSPREVSMKKGDTLTLLNSSNKDWWKVEVNDRQGFVPAAYVKRVEPDAGLSASQQNLAREQGSIAARQAQIEAQYEDLLRLARERQNKLNETAKAYVLVREAAELATWIKGKENHAQVQDVGEDLEQVEVMQKKFDDFRADLKANEVRLAEMNEIAVQLMSVGQTEAALKIQTQIQELNEKWTSLQTLTAERASQLDSAHEVQRFHRDVDDTKDWIREKDAALNNDDLGKDLRSVQTLLRKHEGLERDLAALGDKIKQLDETANRLMQSHPDTAEQTYTKQKEINEEWTQLTAKADSRKKKLLDSYDLQRYLSDYRDLMAWINSMMGLVASEELANDVTGAEALLERHQNHRTEIDARYGIVPQEHRMEIDARVGTFQAFELFGQQLLQSNHYASVEIQEKLESMNEARQELEKAWIQRRMQLDQNLELQLFCRDCEQAENWMSAREAFLSSSSADALDSGDNVEALIKKHEDFDKAINGHEEKIAALQTLADQLIAAEHYAARPIDERRCQVLDRWRHLKDALIEKRSRLGESQTLQQFSRDADEMENWIAEKLQLATEENYKDPANIQSKHQKHQAFEAELAANAERISSVLAMGGNLIEKHQCAGSEDAVQKRLASIADQWEYLTHKTTEKSMKLKEANKQRTYIAAVKDLDFWLGEVESLLTSEDAGKDLASVQNLMKKHQLVEADINAHEERIKDMNAQADSLIESGQFEAAGIQEKRQSINERYERVRNLAAHRQARLNEANTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKLLEQAWSELKQLAATRGQKLDESLAYQQFLAKVEEEEAWIAEKQQLLSLEDYGDTMAAVQGLLKKHDAFETDFAAHGERCREIREAGEGLIAAGNHRAEAIEQRCQQLGAKLEQLGALAARRKTRLNDNSAYLQFMWKADVVESWIADKETHVRSEEFGRDLSSVQTLLTKQETFDAGLHAFEHEGIQNITSLKEMLIEAGHEQSPAIHKRHADVIARWQKLLADSQARKQRLLQMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALREAHAQFQASLSSAEADFQALGALDRQIKNFNVGPNPYTWFTMEALEDTWRNLQKIIKERDVELAKEAQRQEENDKLRKEFAKHANAFHQWLADTRTSMMEGSGSLEQQLEATKRKTQEVRARRQDLKKIEDLGAILEEHLILDNRYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNQSGVSEGALKEFSMMFKHYDKDKSGRLNHQEFKSCLRALGYDLPMVEEGQPDPEFENILDIVDPNRDGFVSLQDHMAFMISKETENVQSSQEIENAFRAITAADRPYVTKEELYANLTKEMADYCVARMKPYVDPKTERPITGALDYIEFTHTFNPLLNRGIGEFKRHCALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFF4</accession>
    <name>A0A232FFF4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_010099</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000284">
        <property type="protein sequence ID" value="OXU29496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FFF4"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000008">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000003">
        <property type="entry name" value="Aldehyde oxidase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF132">
        <property type="entry name" value="ALDEHYDE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="1014"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1829"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU29496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1849" mass="205953" checksum="8C1C4C94B8A4D218" modified="2017-10-25" version="1">MFLFAMGQGNSHESTNHSDLIKLIDEESVIQFTINNIKYSVPKCIRPQTTLNYFIRNFAKLKGTKYMCLEGGCGVCIVAVKIKDEILAVNSCLVPIFLCNGYLIYYYQHSYITQIHFQNNVQRNPFVTMFTSWDIITIEGIGGKLADYNLLQKTLADMNGSQCGFCSPAMLFAEKEVQYAGQPYGMIVASDRYAAYEAVKKVKLLYENGPRKRPLLTVKEVLASNDKSRIREASREDASKPAGKDLKHTIKGTFESGSQYHFTMEPHVCVCIPSEDELDMFVSTQYVAFIQRNVSACLGIAENKINIKVRRVGGAYGGKLTRSSQVACACAMAAQKLKRPARMNLTIEDMMRSLGKRGSTYSEYEVGVDDLGKIQYLNWNHWINQGVSLNDARANFVVDMVKNCYDTSTWTLTVNNVITDLPCSTWCRAPGSAEGLATIANIIEHIARVTKRDLFDVSLQNVSDDDKERVTSMIDQIKKSSVYEDRRKATDLFNKENRWKKRGIGVSLMKFLVEFNIGFHALVSIYSRDGTVAITHGGIEMGQGINTKVAQVAAHTLGIDMDMIRVKPTYNLTSPNDRPSGASITSDCVTSATKIACEELLKRLQPVKDSLNNPTWQDITRAAMAQNVDLCATHLYNVKKDLPKNYSVYGVTVAEVEVDVLTGQHMVRRVDLLEDTGVSLSPEIDVGQVQGGFVMGMGLWTIEQLIYDHSTGALANDRTWNYKPPTSLDIPVDFRVSFLRNAPNPVGVLGSKTTGEPALCMSYAIPLAVRNALDSARADAGNTEVWYNLDGPLTNLSLNLFQFVKLSRFTYLQTVPKYVRSDTTLNYFIRNIAKLKGTKYMCLEGGCGVCIVAVKIKDEILARNPFVTMFTSWDIITIEGIGGKLADYNLLQKTLADMNGSQCGFCSPAMFYIWSSTIWGIHVEFVIYFDSLIARKRTSANDIENSFGSNICRCTGYRSILDAFQLFSTNTASGSSAGVRDIEDAHKSVLCLKKCASCNDFEMIGVNDPKPIYLKLKDADFFKVFTIGQIFEIFNKFPNASYILNGGNTGNGVYRISKKDIYLDINDVTELQNISKSADNLSVCSAVSLENMRACCQKYSKEDGFEYLNQLAYHIHLIGHLAMRNIGTIAGNLMLKHQHPEFQSDLFLILETAGAELHILESEGSKISSTFLDFMEIDMRHKLIYSVVLPRLESNYVYKTYKIMPRAQNAHAIVNAGFLFRLDDKAQVLEQPNIIFGGISAKFFHASETEKYLKGKVLLDSNTLKNALSTLGNELKPDLILPEASPEYRKKLAQALFYKFVLSLKPDKIDARLRSGGTMLKRPISSGKTDYNVDKSLWPVNKPITKIEAYYQTSGEAEYIDDIPHRDDEVFCAFVLAPATGPIDSIDASEALGMDGVVAFYSAKDVPGKNVFVDQTALITYTDELLFAEKEVQYAGQPYGMIVASDRYAAYEAVKKVKLIYENGPRKRPLLTVEEVFASNDKSRIHEITHQDASKPAGKNVKNTIKGTLVSGSQYHFTMEPHVCFCIPLEDELNMFASTQFITFTHRNVSACLGIPENKINIKVRRVGGAYGVRLTRSSLVACACAMAAQKLQRPARMYMTIEDMMQAVGKRIPTYSEYEVGIDDVGKIQYLNWNYWANKGISMNDTVPSFTIEMFKNIYDTSTWSWTYNNVMTDLPSGAWCRSPGSAEGLAIIGDVMEQIARATHQDPFDVVLQNVSDDDRERVTSMIDQIKKTSEYEDRRKAADLFNKENRWKKRGVGTSVMKFHVEFGLGFHALVSVYGVDGTVSITHGGIEMGQGINTKVAQVAAYTLGIDMDMIRVKPTNNLTGPNDGASGGSMASDCCASVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFG4</accession>
    <name>A0A232FFG4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000289">
        <property type="protein sequence ID" value="OXU29442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFG4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="36" mass="4556" checksum="672BE8D84EE93136" modified="2017-10-25" version="1" fragment="single">MNRLVLGMKSEHRRRNKRKLRKRRKAKRKLSFELPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG16</accession>
    <name>A0A232FG16_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01000250">
        <property type="protein sequence ID" value="OXU29706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG16"/>
    <dbReference type="STRING" id="543379.A0A232FG16"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="131"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="348"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="536" mass="60311" checksum="65C7A7AAE6DBBD4D" modified="2017-10-25" version="1">MDGYLIIYTLQNATSEEFGDEEYEFKEDLQPVDVPIEKPKRKLIIKCKNPALNFYEGQTYPKFQPIPLASRGWHHRKSNGDYFTIYPSDTFDSDGIDTSASFRDVNLNEVLLQNLEDNNIIHPTSIQKLGIPKILEGRNVILTAETGCGKTFAFLVPLLQQIIQLKPKRDRGFNRPLGLVLTPSRELTIQISKEAKKLAKNLGINIVTLVGGKTKKMMINPPVGDVDLIIATLGVMSKLVTTNIYKMDEVRHVVLDEADTLFDETFNDKLHYFLKKIPFGDEQQIVGNYPTTTQLTLNSATMPQDLPATLNTIIDTASLLPIGTGKEHKITVRQKFFRVIGPNKPMMLLKVIKPKMKSKTPIIIFANTSATCNFASIFLQQFNISAVTLHGDMPAMIRRSKFSEFQNGIHNIMIATDAGARGLDTTTAKDIINFDLPLISAEYVHRCGRIGRIGSPKDCRVINLISRPLEIVLTSKIEFAARKGNSIPMVDLLHNKDNEEGEFLRPDELQNYNDMEASQAETLKEMAEDFPHRLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGU4</accession>
    <name>A0A232FGU4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000214">
        <property type="protein sequence ID" value="OXU29971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGU4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11249" checksum="2CDAA88AEA7CC934" modified="2017-10-25" version="1">MRCHRVYDALSRTIFDALMPPIHSQAKRALYRAPAAGMSIMRIAACPRCSDSLYTADGFVCARECTIRMLMILPSNEAYYNSGLDEMKTAECCLNFIVAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHN9</accession>
    <name>A0A232FHN9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000214">
        <property type="protein sequence ID" value="OXU29969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHN9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013371206" evidence="2">
        <location>
            <begin position="29"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="125" mass="13827" checksum="FCB857752D0DB43F" modified="2017-10-25" version="1">MAAHLRLTYSVFMCVELIIAAAPRPIYATSFTWNAPIVSACKSVRLAERRAGKICIRNDDLQASHVQYSVPAEILLNHHCAHNRLIKSNEALYADGEAAAMTQFAGSTRQKADTRASDSREQNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJP0</accession>
    <name>A0A232FJP0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000117">
        <property type="protein sequence ID" value="OXU30803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJP0"/>
    <dbReference type="STRING" id="543379.A0A232FJP0"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="668"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="698"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1124" mass="127189" checksum="3FD01D7BA8BE06F1" modified="2017-10-25" version="1">MAYIPESHHSRGETVVFKSSPRPVGLQRDYRVMADGYGNTTLHYAISYQNFEMVKQLLILGVDVCAGNKDHVTPLQLAIANKIPIDCLGPRIYVLRQHDRFRNCLDSYDCAIKARDDKVLDYMQDFRISDKNNRELVKMLLNAGADVNSKDRYECSPIHCAVFTGDLELVKILIEAGADLNRQNDVGATALHAAVLCRDEPMVELLLNSGANVSFPPNCQNETALYWATMLNWGNSFEVIIRKLLEAGGDVSQSFEFKDPDNSEDLEPDSNIGAFERTPFNFILMYGDINLIELCLKKYNAYLEGPGGNLDVSDALKFAAYNEDPRVTNLVLDSGITNCNFGFSALHHASAWFRPQLVRMLIGDGAEVDITVEDEVEVYKQYTPLAYCIEAKDEQQCESEIERPNAAEDRRKTIKLLLDCGANLNQKINEKTALEIAITSNDQLMEDAERLIIEHVVLVEARTNKKVLDEYNLKLIDENPRLKMYYEKCQSELTAMKTSMIKGTFITYFSVLTKPLQAVAPYVKNKESVKNFKADYRVAYPAYAWRLKQKFEAAVARQQKIELVLPILSSMKEFADRDSFDNILSYLSEEDLDMLIKCCKPTADLGERVPLFSLCLDSYDCAVKARNDKVLKALGCNRIRSDDDNRKLVKMLLDAGADVNSKDLFECSPIHCAVCTGDLELVNILIDAGADVNGHNDLGVTALHYAVLCRNVSMVQLLLNRGAFANVHYDDVCEPPLFWASMLNWGNDLDVIIRTLLEAGADLNQSRSSDLNYSDSSLFSDSDFLQTPFHYILMYGDIDLVNLCIEKYNADLKLTGENMDENDALKFAVYNEDISVMNLMLEKGITKCTYGLTALHLASLWFRPQHVQQLITNGDDVDTLVRGDYDLYSDFTPLALLADNTTFSNGATQELYEALECEMDRPNAAKDRMRTIKVLLDSGANLNQKIHERTTLEIAISSRLANSEEPDVAEHLIIEHAVLVEARTKKKVLDEYNLKLIEENPSSKAYYEKCQAELTAMRNSKIVGTSITYFSVLTKPLELVARNFKNEKFVQEFEANYREAYPVYAWRLKEKYEVARARQQKTELALFALSRMLKFADPSFLAFETVLKYLTNEDFDSLINCFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK97</accession>
    <name>A0A232FK97_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000124">
        <property type="protein sequence ID" value="OXU30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK97"/>
    <dbReference type="STRING" id="543379.A0A232FK97"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="244"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="453" mass="52053" checksum="D5B75370D84BD7D8" modified="2017-10-25" version="1">MTDTAVVDGGRIIKMEVDYSSNCDTKIPECKKLAQEGKLHDALDQLLVLEKLTRTASDMISTSRVLIAIVEICFEAKNWSALNEHIVLLSKRRSQLKQAVTKMVQECCTYIDKTPDRETMIKLIETLRSVTEGKIYVEVERARLTHRLAKMKEEDNDIAGAASVMLELQVETYGSMTRREKASLILEQMRLCLLKQDFVRTQIIAKKINIKFFEDENDEETQVLKLKYYELMMELARHEGWYLELCRHNRAVLETPSIKADAEKRHVALSRAVLYLILAPHEPEQADLTHRLLADKLLEDIPIYKELLRLFVNPELIKWSGLCEIYETNLRATEVFSSATEEGRKRWGELRNRVVEHNIRIMAKYYTMITLSRMAELLDLPVEETEQCLCNLVETGVISARTDRPAGVVRFTRTQEPAALLDEWAGSLSKLMSLVNNTTHLIHQEEMLASAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL44</accession>
    <name>A0A232FL44_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000070">
        <property type="protein sequence ID" value="OXU31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL44"/>
    <dbReference type="STRING" id="543379.A0A232FL44"/>
    <dbReference type="OrthoDB" id="7545861at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="21208" checksum="BF9AD86F3C027AC1" modified="2017-10-25" version="1">MANYNPNEVVDILITLDECGRNYRLTARTYVERFPNRRHPNARQVINIKRRSRNNPLHQQRQRNRLQNNNDPRLLAVLAMVHLNPHISTRQIQRELGVPRSTAHRWLQSVNYHPYHITLVQELSESDYVLRSYTNTNRPYSGPKKWSRNAPHVLVVGSVMLTRAFFMLISGMKNARMQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLD3</accession>
    <name>A0A232FLD3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000069">
        <property type="protein sequence ID" value="OXU31320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLD3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="20596" checksum="3806D78D09079C4C" modified="2017-10-25" version="1">MADRRVLPYGAIRDLTKGDHGMEVLAEQGDKEKPPISGSPTPKPVQQGNTFSGLKRIITEVNEYAKGKTNVYGPIKTGLSNALIELGKIEKKGMALLKVPELRLRVRRTGTNSSTQQMIEYRQYRQKAIKARKEEEEHNEAGKGSRRPNRGLSVHTKEHRRHLKTDSKTQSFGDPVEGVARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLF3</accession>
    <name>A0A232FLF3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000047">
        <property type="protein sequence ID" value="OXU31571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLF3"/>
    <dbReference type="STRING" id="543379.A0A232FLF3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="140" mass="16336" checksum="C65286474C5D40D7" modified="2017-10-25" version="1">MWEVSDLNAKEISKDHLPHFSQFNQNVKNGSLNLDAEKTLLFCELYTDKWLLKKPCNFPMTSSNTLGIGISSDELGYLIFHSTQTELYDENNIIFFLRLLWLQAKIFLYQGEADISIRTLELHLRLLSHVLAQFHQFNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM75</accession>
    <name>A0A232FM75_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Timeless N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000038">
        <property type="protein sequence ID" value="OXU31683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM75"/>
    <dbReference type="STRING" id="543379.A0A232FM75"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="5">
        <location>
            <begin position="31"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU31683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="599" mass="69221" checksum="717909C1BA0304D2" modified="2017-10-25" version="1">MTAAALQISDLMYAELTATCDALGYNDGNKFLLDKNAIEVLKDLIRYLKRDDDIHSVRRYLGHSKLLQRDLLKIFVEHVNKTELWNVLLRLLINLTSPALMVYNEELPSEKITRSYYLQILSHLQEYKSAMANDAVWGIVHEKMKNILTIESEERGEENEMIMERILTLIRNVLRVPASDSENRTDNDTSIHDEVLFALNTTGVTELLVYIASSSKEQQYHMQILEIIAFMLQGQNPARLARVGLQRSNHEKEAEEARLVHMLQKEQAEKLAKMKKYAGSRHSRFGGTYVVQNMKAIGDNDMICHKPYQKIEDLNFSVTKQKMKKRKNKNELMSLGEERISALSVRLFLKEFCVEFLNGAYNPVMRYVRSCINGTGAVASDASHYLWALRFFMNFNRHYNFRVKYVSETISTEVFYLVQRQIEHNYEMILSDKKKAAFWSTRMHLGINAYQELLLTLIEMDKSKDDGVKRSSRAIMGNIFYVPEYRDTILSQLLNYNELTMSRDYLVDLVTTVHIFLKMLKNFCEKERNVVVQKVKRKKPKKKSKSANKAATQPAAPLPSLEERWDDVGPEVSAVMQQNEIPVVAPFDGASEVPIDDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM82</accession>
    <name>A0A232FM82_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000023">
        <property type="protein sequence ID" value="OXU31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM82"/>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="510" mass="57313" checksum="77CB48161CA3CB1A" modified="2017-10-25" version="1">MRRTNSTGLRLDLTENTPDSLANSASRLPNLVVEHAEQLHQPHELYNHHNHHQQQQQQVIGENLNSKLPNVVEGSMDYGSERRSSRYLADYDVAAAAGLKSIYHQDVVAPSSSLNYGVAESGYLDRGYHPIRTGTYERCKTATFERDNLERYDNRIYPEDGSLRYDRARNERTYQESDLDAPYEPAKTVRSYAPETVQDGNRRYSRDLTDYEYARYAEETLKLEPKKPGGGKVTYEVSTTKGYESGVKTNNRDQAYELATQQDLAGRAYVDPSKYHSVGKMYGTLPRYESSGSKYECEYERGAASNLSSAGVGTGYETTTRRAKVYEGIKYELTTSKSYERTKYDTTGSGSSRYNDGTSKSYEQTLKIGESSAELGGGYNSRKNPETEETTGTTGSGTQEKLNGYRKNNFEAYGVYSDPEDDHGFIAEKKTPQYNYKGVVVNASGESSVVEQKRAKEAGQTEMSGSPWCRPTILLLLLVLLVVIFVLVAGILLYFNCELFCVVFRCMFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMI7</accession>
    <name>A0A232FMI7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000022">
        <property type="protein sequence ID" value="OXU31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMI7"/>
    <dbReference type="STRING" id="543379.A0A232FMI7"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051121">
        <property type="entry name" value="FAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796:SF4">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="339" mass="37203" checksum="BE6E7B0B5112C705" modified="2017-10-25" version="1">MPLHGKLRMCCQLVDKSLGARWIARIAGRNFSTGNAANMRFVQFVNKNGGPQHLGVQLKQGGDIIAISVLNSRIPNTLKKFLEGGEEFLKKAKRSDDFDLKAEVERIVAEGRSVIPEKDVTFLPPITQMDKLACVGLNYSGHCKEQNLEPPSTPVIFSKFPSNIIGPHDDIHLPTISDKVDWEAELAIVIGKKCKGLNNNEAEDCIFGYTVAQDLSARDWQKGKRNGGQFLLGKAMDNFCPLGPAVVTKESIADVKNLAVKTWVNGQLKQDGNTSELIFKTNDIVAYLSQFFTLLPGDVILTGTPAGVGFARNPPEFLKKGDVLETEIESLGRLKNNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN37</accession>
    <name>A0A232FN37_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN37"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="11054" checksum="0AD9760F2FE46E77" modified="2017-10-25" version="1">MELRTVDLANLLTCTLSRSKLQHPSSSLEPVPRTCNERIPKKQQVSAHSYTWITNTTRDRNTERTTPDRNIRRQLLYTKGDRCEMECAMEWNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNR5</accession>
    <name>A0A232FNR5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNR5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="183" mass="20605" checksum="6471C02FC2E39A15" modified="2017-10-25" version="1">MTLRSVMAASRMRIVGVAVLVSRNSLLSQFLLNTLSSAVYPEPYGFGVKKCRNSLLSQFLLNTLSSAVYPEPYGFGVKKCRMIGVESKVILTNHSQEKILPRFLPEIISDLSGFSSKFYSGNLLDLKNLGSFQKQLILAETTVTIRNVKKLIYMTDGAKQQFKNRFQIANLNNHKEDFQVDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEF3</accession>
    <name>A0A232EEF3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005376">
        <property type="protein sequence ID" value="OXU16708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEF3"/>
    <dbReference type="STRING" id="543379.A0A232EEF3"/>
    <dbReference type="OrthoDB" id="1607513at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="505"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="745"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU16708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1117" mass="126766" checksum="99531394A35BF0BC" modified="2017-10-25" version="1">MTNPDLYDKLEEGFRYTAEKIVKLKDLANYLKEIEITVTVPEIVKAWKALVEAFKECRAEQNVGTGSAAKEHSFVYYQDMMFVLAKDQHRKPISTLNVTHQSKSLAKPVASQSTSMILQRKKSKLMQQDDDSLRSLNKKIIETLDVVQKGCNPTNSLTPTEEGFCYTAEKIIKLKDLANYLKEIEITVTVPEIVKAWKALVEAFKECHAEQNVGTGSVAKEYSFVYYQDMMFVLATDQHRKPISTLNVTHQSKSLAKPVASQSTSVSPRGPGAEHSSGLSASVRRHPSSLAVSGPKLPRKSVMPPLDDFAKKKSKLMQQDDDSLHSLNKKIIETLDVVQKGCNPTNSLTPTGNYIQVIDQAFSKVPDGMQDQCLQYVLNQLYEFDIPEIVKAWKALVEAFKECRAEQNVGTGSAAKEHSFVYYQDMMFVLAKDQHRKPISTLNVTHQSKSLAKPVANLFIVDHKQNDLFIVDHKQNGMQTVFAKFMKEKKEKYYIRYRKLVVPQSMRSIYWKFFGFLADENGEIVTRVRIVCLLCKAQITYNRNTSNRRMHLQNKHVQELHELEALSPPMKQIITPESKERRAQKRMLKAAMASSSQHIYTTNADGTVQIGGDIQFVTDPSVAFPEQCMEEDVTVNINKPLKFVIKDGTIDNVSTTSNQNMTFMLSEDQQQQTSSNNKSDSGAIVEFLIIDLQLPKIVQEQVDIIEQEQDIEEIDHKRNGLQTVFAKFMEEKHSITYRKLVVPQSMRSIYWKFFGFPADDDGEILTRVKIVCLLCKTQIAYNRNTSNLRMHLQNKHVQELHELEALSPPRKQIITPESKERRAQKRMLKAAMASSSQHIYTTNADGTVQIGGDIQFVTDSSVAFPEQCMEEDMTVNINKPLKFVIKDGTIDNVSTTSNQNMTFMLSEDQQQQTSSNNKSVSEAIVEFLIIDLQLPEIVQEQGFQRLIATLKSPCQIPSKNSLEKEIIPTTYNTFRETILSNISSLTSEVSLAVEEWTSNFGESFFSFLIYYQSPGEAALESKILCTIHGPRDWDELQWGTVLDTMMNDWCIKLEKTTAVIASTTRSQLTNALITRGLTVVPCLLHSLQVCAQTIFENDEQVVFSIFIQLELFCHLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEQ8</accession>
    <name>A0A232EEQ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005233">
        <property type="protein sequence ID" value="OXU16849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEQ8"/>
    <dbReference type="STRING" id="543379.A0A232EEQ8"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="5"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="525"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU16849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1037" mass="117429" checksum="AB4271A01B55750F" modified="2017-10-25" version="1">MGESVLVTTRSGRLRGSIATSIEGFDYCTFKGIPYAKPPVGELRFKDPVPAEPWSGMRDATEYGTICGQYDYVVSRALQGSDDCLYLNVYVRSIRPEARLPVMVWIHGGAFMFGSADDFLYGPDYLLKKDIVLVTCNYRVGVLGFLNFEDEVAPGNQGLKDQIMVLKWVQENIANFGGDANNVTLFGESAGASSVHYIALSDLSRGLFHKAILQSGVSCNTWACTSNKSSAYKIAEVLGCKSKDPKELVSFLRTIKCHKLVEAQELIRLPQEKLRCIFPFGPGKDDKSKTPLMPVHPSEATKKGVHVPIIIGCNSREGFFSLPGMKQQHFNQLDSNFENYLTDVTKEMIRKNNITPEGLKRLYYGSEKICEENKEKFVDMYTDLQFVEGIHRVVKAQVKRSSAPTYFYRFTYDKDFSLTKSYTNTTLPGASHFDEVQYLFNMQFYEILDVKRPEPGSTGHRIMEQMVEMWVNFAKYGSPTPVLNDLITTYWLPVTNEKIFRTLNIGDDLRMESTFSSSVSFKMKKPVVKTTCGRLRGSIQKSIEDYEYCAFKGISYAEPPIGELRFQDPRPPKSWEGVKEATEFGPCCAQYDQFRRLYEGSDDCLYLNVYTKSIKPKTRLPVMMFIHGGAFTFGCGDDMFYGPDYLLKRDIVLVTINYRLGVLGFLNLEDEIAPGNQGFKDQVMALKWIQSNIINFGGDPDNVTVFGESSGGASANYLGLSPMSKNLFHKAISQSGVALNTWASTPSPKQYAYKLCKSLGRDIHDSQEIVEFLRSIDCIELAKVSEKIRTKEEKKQLLYPFGPGVDDKSENPFLTEPISEASKRGMDIPYLAGYNNREGIYSLSGLQGTPLEEYDNNFPKYLHPHLLDLLKKYNITPDGLRVLYNCHVLTRDNYVEKFADLLGDMYIVEGLHRTIALQVLNKRAPHSYATFLTLGASHFDELPHLFVMRFCETLGVEPLQKGTIAYRIMEQMTEMWTNFAKYGRPTPDTSKLIPIKWAPVTNPTLLRYMNIGHELMMDGMLNVEQRLCRGRPMKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF17</accession>
    <name>A0A232EF17_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005147">
        <property type="protein sequence ID" value="OXU16950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF17"/>
    <dbReference type="OrthoDB" id="7700944at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="14567" checksum="AE64C29DDED6B59C" modified="2017-10-25" version="1">MNKGSEPTFVRGEQTSIIDLTFASDDLSTYVRKWKVSDQYTHSDHRAIMYEIATASGPKTYNMRKWNAKSLDREAFEVMMEGEGLNAATYRAVAASGLLLRGAKNLAGLPGKLAPRDRSPLSASPVEGGSLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG46</accession>
    <name>A0A232EG46_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-dependent oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004866">
        <property type="protein sequence ID" value="OXU17326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG46"/>
    <dbReference type="STRING" id="543379.A0A232EG46"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000026">
        <property type="entry name" value="FAD-dependent oxidoreductase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="4">
        <location>
            <begin position="100"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU17326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="529" mass="59538" checksum="7E5BFED840FD9DDE" modified="2017-10-25" version="1">MLRLLVKNGSRKANVSCAQLGSFFSTKSSKGNDVNLGENIDLGIEHPMHKVWRCIKRDVAMMKKNVKFWKDEKNPAIDEKTNRVIDWDDPNAPIFPNHCDIVIIGGGAIGSATAYWCKKIFRGSLRVVVIEKDPCNILLKNFNISKNYFNLIHIHKQDMKAYLLFQYTQCSTVLSVGGLRQQFSLEENIEMSLFGAEFIRNANEYLGIEGEPVVDLQFHPYGYLSLATEESVDILKRNHKLQKSLGAKNVLLNKFQLKSKFPWLTTDDIELGCLGLQNEGWFDPWLLLCSLKRKAMSMGVEYITATAKGFNFKVNPNVHLVGVPPGEYEQLEYLVVETEDGKLRPITFSKCIVAAGAFSGEVAKMARIGTGRGILKIPLPVEPRKRYVYCFHAPDGPGLNTPLTIDPTGVYFRREGLANNYICGRSPEEHEEPAVDNLDVDPEFFENNVWPVLAKRVKAFENLKVKSSWAGYYEFNTLDENGVIGSHPYHQNLLFATGFSGHGIQKAPAIGRAISELIVDKSVKEVNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG78</accession>
    <name>A0A232EG78_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004826">
        <property type="protein sequence ID" value="OXU17365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG78"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="11170" checksum="1BE343035596A89F" modified="2017-10-25" version="1">MTPCFPFMAVDPDNMLPTSYACLSLIASAQENLGFSSPRCLSKYRVYPPEGKEKKYSVLKWPHIPRGLRVILHNALEHLSTDLYSRFNPRPYVRNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGW4</accession>
    <name>A0A232EGW4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Attacin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004654">
        <property type="protein sequence ID" value="OXU17597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167125" description="Attacin C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="25901" checksum="06DB2FF8B95D5CB5" modified="2017-10-25" version="1">MKLLAALLLGVVVATLAAASNDSVHDSTILDRLARDKRSLGIDESFKKDVEIKTKSGTSIKISKSVSYNDGGAVAHLPMLIDSIGTNKVRVLQQLQNKRNYITGGVQAVVGTGGQGVGEDVGTGSHAGNGHVAVGGQIGTGGQIVTGGQIGIVEAQVDPHGVLSAQRNRQSFLHGLSQLIHYKHELNKQRLINMVHGVSIGSLESFLARKRAVHVEKMARKVIALSKIKPIGAPCCPTGPCCPENQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGY0</accession>
    <name>A0A232EGY0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004643">
        <property type="protein sequence ID" value="OXU17616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGY0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="38" mass="4653" checksum="3F6EF6BF51422AB2" modified="2017-10-25" version="1">MFHIHVHYAQLRCISEKIAQKFEEPWQLSCRQWFSAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH88</accession>
    <name>A0A232EH88_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004554">
        <property type="protein sequence ID" value="OXU17715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH88"/>
    <dbReference type="STRING" id="543379.A0A232EH88"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="1">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="164" mass="18834" checksum="C364996BCF1A6102" modified="2017-10-25" version="1">MQAFCLELKENGTRYVLLTLLTFVCQPVAIDFESNTPDNITMHQQKNSVAPINQIRSAPTERDATHYNMNHGKRGLAFIFNHEFFSVSHLKARCSTNVDCENLAINTLESLGFEVNDLHNSTHKDISKYLEKAKLIWQKWIKPILKERTETDSQPTVLSAFLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHZ5</accession>
    <name>A0A232EHZ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004382">
        <property type="protein sequence ID" value="OXU17973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHZ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="315" mass="37406" checksum="D402C22FCD2F6BD1" modified="2017-10-25" version="1" fragment="single">QSNTNIVNSEKPEQKRNKDCILKLTRLEEEPRRKRAKVENQFFLVNNQPNIHTSGNSHWLQKHGDRRRKDEEKRKGQNQKKQKEEALKIKKARVLLVRSEAKTSQDSTISRTPLLTSCTECREDCWYSGDALHDLPWLLCIVCQTNWANEQSNTNIVNSEKPEQKRNKDCILKLTRLEEEPRRKRAKVENRFILRSIKICIKKKPNDKKKKSVKNTETEEEKTKRRERDRIRKREQRKKQKKEALKIKKARVLLVRSEAKTSQHSTISRTPLFTLHDFPWLLCVVCQTNWANGKCVQRIPYECRTCRIRRSSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIF7</accession>
    <name>A0A232EIF7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004269">
        <property type="protein sequence ID" value="OXU18125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7700312at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1358" mass="154973" checksum="077DD4ABE871FBF7" modified="2017-10-25" version="1">MRWRFGGHFEPVLTTCALDWLECPFALADYIWSEVVTDVAECLANESILWRFLKILALLLICTTVVHLIYWQVRWTKEIQRNNQNLKQVGYKVQDLELKLNILTYKAQYGTWPLPNLSKTSAKTDSQTTQISRSQFGKENSWIKNLLTRYCDLLGRLEKSRYFQTSFRLRTTDLTFRKRNTKEINNVNSTGYQTYMDTEISQSEAEFSDNVSTDVSILSSSLAPTWKDQIVTSSPSEVEIQSDTRETLYEVKRRLENLHFSLKSYTLRDWTVAAHTNSYQGRGNNGRGYNDLISRKRKNNCNTSIDLRKSIKKHNVSDLIAMYAAYNAMILDRDKPRQFASRPPNDEQSSISNAMKCNRDKNNVSKKDGEFNISKELSEYKNSVNKSILHSNVTTGAKTMEMHKGDGDSEYFSERSASSKNNDEISVVSEKSSVDETSKESDSDDRSTSALLEEALRIKRDLLLRIELRKKFELEVQESNADKKTDECTYWERIENQFEPKMLDMISEETSDSSSTNRESKINVYKTLEKCANAQEVKINVCNKDRLEEDKSKFSENEITIADDVSINLLNGKSQNLSMAIEENVQENSNSVFQTEPVSKDDENQNIETLNLVSELNSSKLTESSSDTSVNRLIDRLIESERRSKSARSSSDSKSKKNLSMDSINSLIDNRDSIERAQSENEESNDCPRMPSTEADDVDNLAAVQSLPSEDAENRNILGEAMLKKADDKKNGIDEKKTNTIVEVNTQNSEAECANNLESKDNKICSSSVDEKACVELLMFENDEFLRKQVPVDELINVKSLIEEVSEKNTIESIEKKSLSLADNNPTVVQVSNSTLYTPLQNAEHSVTKIQKNINSITHQKQSPKNVNDFRSYRHIRTKSNLNLSSTEKQSFSPMFRRSRSYDTPREISNNKSNPEGEAPSDSFTSSSKSSSISHTPREHKYNDEDNAELDETKKSPFESLDVSSKSSLKSYFEIMTVEDDSIPEIKRDDSYKSLSSRSSKSQIMASLREITENRNSKADVERKSSLESLILSSKSSFKSCIPILKNRLESTKKNISESRSSLIQEPLANTLDSYRIDNEKLNTELQNFNNSKQETTVYVNVTNENDEITSKVLNPEQFFEYIKNKEIELKNDMNEEKINTSIMDNNHIMILSDSKMSTLIPSSSGNIDSTDVSSLGSSSCQLHNDQPQAWPCKIDSKETEVLVKHSTLDISTSITDIHNTFFTVENNEINELKIFEIPEEITKEDYITFLQMMNENPVLSQLPNVEESSTDLLIEIVSSTYLHLNTLTIHKFNACYYRVNDNCRFATGIHNNRVNFAFDYYRTVLAAEHVDNIVHLGVLNYDVFVSFVIFLDKNMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIK2</accession>
    <name>A0A232EIK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004201">
        <property type="protein sequence ID" value="OXU18207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIK2"/>
    <dbReference type="STRING" id="543379.A0A232EIK2"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="324" mass="37897" checksum="2B0DEC7F07A022DB" modified="2017-10-25" version="1">MACDLDRLAKETLSEKMRTNYLEFDGVVLPEEYKLYADQVENFEVYDDDVYVCSFQKSGTTWTQEMVWLIANDLDFEKAKTPINARFPFLEFSGTIMTARAAMRDPNMEVPSWVTKSVDFCKTFPRPRFIKSHHPFNLLPRQIRTGEKKPKIIYVARNPKDVCISFYHHSKLLEGFCGSFDDFCKLFLGDKLVYAPYWNHVRGFWERKDQDNMLFLLFEDMKKDLPSVVRKTAQFLGKTLDDSQVQALCKHLSFESMKVNPALNRVTTIAWIRSLNLSNDDSEKNEFIRNGNVGQWKATMSEEWIKKFDEWIAKNLASCKGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ18</accession>
    <name>A0A232EJ18_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004118">
        <property type="protein sequence ID" value="OXU18345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ18"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6523" checksum="CF95D023DBBB9CDE" modified="2017-10-25" version="1">MACRSSGGVQRSYDHPRAVLQAGQGGTNDPVEGEEQGPARWKILTDRHFVRSSSRVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKC5</accession>
    <name>A0A232EKC5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein smoothened</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">TSAR_005709</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Alberta</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003824">
        <property type="protein sequence ID" value="OXU18795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKC5"/>
    <dbReference type="STRING" id="543379.A0A232EKC5"/>
    <dbReference type="OrthoDB" id="10064659at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15030">
        <property type="entry name" value="7tmF_SMO_homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07451">
        <property type="entry name" value="CRD_SMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035683">
        <property type="entry name" value="SMO_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041771">
        <property type="entry name" value="SMO_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF35">
        <property type="entry name" value="PROTEIN SMOOTHENED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012556707" description="Protein smoothened" evidence="20">
        <location>
            <begin position="18"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="59"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="22">
        <location>
            <begin position="226"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="667"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="772"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OXU18795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="824" mass="93408" checksum="C21E4BD7EDA77210" modified="2017-10-25" version="1">MILQLVCLAILVPSARLELDHSHSGGVNDDNKTWSDLGPRHRIKDPNFLMDPMDYQHCKKPAKCVKMINTTCLGATLPYDTTSLDLMPKYTTQEMIMEKLHILRGLEHIPKCWAVVQPFLCSLFLPKCVNDTVDLPSQEMCKVVSGPCKILLNHTIWPNFIKCDNEELFSRSCKSEIRELKFNTSSSCLYPLVPTDNALAIFEGIDGCGTVCSDPLYKPEEEKQIHSFVFWAAGLCGAFTLFAVVTFLIDWRSANKYPALAVFYINCCFFVNCIGWLAQFLPGSREVINCRKDGTLRMSEPSGDFSCLIVFILVYYSLMAAMVWFVILTYTWLMSIQALGKIQGRIDKKSAYFHLLAWFLPLMLTATIMALGEIDGNHTTGICFVGYNNHTVRAWFVLAPVMTSLLIGGYFLSRGLILLIRLKISSQEFIQEQASSKIRETIVRMGLFSLFTLVAVLVTFYCHAYDFEHSSEWKKSFRDYIICSITSKYAEISDCKKEPRPSAGKLQFHLLSVFFSGILMSHWVWTGSTADTWMRFLRRTCNRETEEPVKLKKHKVIAQAFAKRKMFNDAGRLSISLRNTHDDPVGLNFDLNSVASQDFSSTWAAALPKLVTRRGALVGASVSSNRRNSTDSQYSFSLRRVSVESRRNSCDSQFALSISEMKAELKTSRVNKNGKRRKKIPERTRKRSESTKRGRRDLEKSRSGRMISTFRRGSTTSQESQLGIQQLLSALPILPASGTSTVPLQVPNMRRRAGVDEGQLALKHVERLLPFSFSGQSDSDENLSSEEKQNDVRDKDIDLERGREEKNNQDSENEDSQPEDETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKM6</accession>
    <name>A0A232EKM6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_016576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003756">
        <property type="protein sequence ID" value="OXU18895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKM6"/>
    <dbReference type="STRING" id="543379.A0A232EKM6"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF37">
        <property type="entry name" value="ODORANT RECEPTOR 46A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU18895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="414" mass="47570" checksum="1EB00D9F5D3A5583" modified="2017-10-25" version="1">MLSIHFQVLTISGVWCPNHSSSVQRIFYKCYSFIVVVLMYSLALSQLARIIFVKQSFNEFNDTFFISLSTNFACFKAASNLVNQKQIVSLVNMFKHNCCLAHNDSERSIQKQYNDSCSKIIISLLILVETSAFFVVVAPLCGTMDNQDLPYQVLLPYDLSNKLCYWLTFVHHSLGAVLFTAISITNDAVITGFMMHVCGQLSILQHRLVLLSRSLANDVSKKGRTTDFDIMLERDWLRQIVYHQNHISNIAKKICWTFNEIVICQFCISGLEICVSVYQLSVRNNNTVELCTYAIYLMVMLGQFFVYCYFGNEVTLQSKITHRAIFDMDWTSFSLSLKKDLTLIMLYSSKPIAMSCGPFVHLTLESFTNVKFHFKQLPFKIILFLAVVDYSEHFFLFQILKTSYSIFSVLKTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELW4</accession>
    <name>A0A232ELW4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003490">
        <property type="protein sequence ID" value="OXU19337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELW4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="52" mass="6232" checksum="30002B897B6A72C7" modified="2017-10-25" version="1">MKIRAEIVNHVYEDCEYFKPFIIGDEFLNITDRSNYEMHMSMNGMYVSKTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMA8</accession>
    <name>A0A232EMA8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003395">
        <property type="protein sequence ID" value="OXU19486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMA8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="58" mass="6444" checksum="8BDA44FADF7A204F" modified="2017-10-25" version="1">MYRAPKIRASASTSVSALLARKPERKVYVLILCVADADWATAIFLIFISQLPVSTPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMG0</accession>
    <name>A0A232EMG0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003373">
        <property type="protein sequence ID" value="OXU19527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMG0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="11773" checksum="A6B9FBB26D9A94B0" modified="2017-10-25" version="1">MRYLHGEQHVVTQISKDSTSSNSKDLLRNILEGRYFNLNLESSAITLLEVHVACKIDSVFESVVDLDLETIRLKVQNVWKIMNQQSALYGGGGQGATPENLAILAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMI8</accession>
    <name>A0A232EMI8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003367">
        <property type="protein sequence ID" value="OXU19538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="393" mass="44898" checksum="96872C22E40B6A13" modified="2017-10-25" version="1">MEGAHFVEKMDYNLLAVESYKEKKRSTKDVTLLIIFAILTLVWINIGIHGFSAGNIPSEIISDIKLWINNNKIVEALSYNDLLLIGFIGFAIFLAALFLIMIAWMTKFMITMTLCFQLGFLLSFFILSMRSSFCHATQLLFGLTIFGIKIYALKKVGMKIVCKVLQDIINVTISIVCFIDNFRRMLLHGMFTHWYRTLDKQNISNAVSFHYFATIVRHHMGTIAFSSTIFAIVPAIRALFNSRKDLLRLIKNRPSALYALWYALWETTTXRTLDKQNISNAVSFRYFATIIRVCLXQVTFGLIELGIYFILFINIKTEIQLYDLRTSDQDPDLHSLKETTTIAIGIFSLVISAIYLVIFNNAAEAVILCLFEESNSSKPIDKDGDYLCENNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN68</accession>
    <name>A0A232EN68_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003221">
        <property type="protein sequence ID" value="OXU19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN68"/>
    <dbReference type="STRING" id="543379.A0A232EN68"/>
    <dbReference type="OrthoDB" id="7701300at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF70">
        <property type="entry name" value="NK7.1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU19776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="305" mass="33186" checksum="C295006EA70F5A24" modified="2017-10-25" version="1">MPSSDAESPPADEHLVLRSKPPTNNNNNNNHHHHHHHHHHHHLEKRHEETASSPPTSRTTALGSSRHNQQQVASWHEHVYATPPRTPTPHRISDILGWSRETTAAGGRMQGKLLAPTPRRFSAGSPLVRAPLPIYSPLPAHSPASIHTGSLTSPPCTPSPASPMMSPASAASFCSTTTQPPSGFQTLASATTTTSDDCSDERPLNLTTSSRRTRSPSNSPGSLLYARSTTPTTDARTAAAAADLAEDAESAERKKKKARTTFTGRQIFELEKQFEVKKYLSSSERADMAKLLNVTETQVNHDNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN85</accession>
    <name>A0A232EN85_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003211">
        <property type="protein sequence ID" value="OXU19787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN85"/>
    <dbReference type="OrthoDB" id="7671074at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="578" mass="67041" checksum="9DE4642CE4B145EE" modified="2017-10-25" version="1">MGNYICHGESGVRRSDLLTRAAATGRKMQCAATAFWLLFCCSVLVSIDQEARRRVITGERVPALVRSLVRLTNSWYFYHVLTFLITSAFRRTLLARLGSERYSRKFVFSILMNLSYFRLKFTLSLALITLASSGVYSIPSASGADWDVSPADRSDYYPSHHLAWMRFDDSPFVTRAINRPSRQRLRTPIKRSVDATDLERRDAADVSLEQIAGSKSVREARMHQGSPETWSKQPLSVQFRNRPSLDQMLPDRYSDDGLDSDEAANLPPMIRAHYAPKTDFVTSGRARGAPGIDGTRLPPPEGRESRDMPIARSYDEYDVPIFRNIVREHDFDVQIPRNYYNPNRYRSQRDYYYRGSGGTQNPYVYDRYRDEDEDYEAYSRYRPTHKPKRIIYYATLPEVVRKPVDLRNYQRPYDSLVRSPEAQIDGDRNRLTPNAVEPSRRPLRYPYDNYDNYVKRSSYYDRRRPPYAAGEADRPRDQERNRGSYREKMRSDDRKLENQIARSGDDRRIPWPVQIGTEVSVKDNERIPGRKIFGQIDGYERYEGSRIKKTSGNADRKEDINEGSGSNNSNINSDNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENJ7</accession>
    <name>A0A232ENJ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003125">
        <property type="protein sequence ID" value="OXU19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENJ7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="11857" checksum="5027526C8EE6116C" modified="2017-10-25" version="1">MEACKEATSRASVFVIFFGAGLKHSYLSVEATAARRTKFPGSIERRKLAPTIGKLGHAGSQLAMLICDLKTLTSRKMLTLLVANHEEDDSNCKFILVASRKKTPDKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP16</accession>
    <name>A0A232EP16_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003043">
        <property type="protein sequence ID" value="OXU20066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP16"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="10542" checksum="0D28526567B82D0F" modified="2017-10-25" version="1">MLSGTPGVTNLTRQRRSQRWLPGTERNSITRGNSTNAAQQKPWVAVISAEPSYLLLVTAPGGFASSSGIREDPRAIATRPPLTVAHPRRASRSQKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPS1</accession>
    <name>A0A232EPS1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002897">
        <property type="protein sequence ID" value="OXU20365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPS1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="9805" checksum="075507D454799ADC" modified="2017-10-25" version="1">MYQRPAVSCCKYPEVLSAESRETVAGIIGKESDRTSSIILFGGYGVMDNRILFTHTGSGVINALETKFTSSSLLNDLVIALFLPVKSLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPS6</accession>
    <name>A0A232EPS6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002909">
        <property type="protein sequence ID" value="OXU20341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPS6"/>
    <dbReference type="STRING" id="543379.A0A232EPS6"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17047">
        <property type="entry name" value="Ubl_UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039120">
        <property type="entry name" value="UBFD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057455">
        <property type="entry name" value="UBFD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470:SF0">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25343">
        <property type="entry name" value="PH_UBFD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="298" mass="33374" checksum="76B962E2B771BB3A" modified="2017-10-25" version="1">MDIEMAKNDNNDNCCSPSSHSNLLSNSNSTEASNETPPGNHSSTLNNKEDNVPETDKKEDLREKINFKVIYNKKKIDITFALDGTVAELKGHLQNIISVPQSMQKIMIKGLAKDDQTLRSLGVTKDAKVMIVGSKLDDVLAVSIPTKQELTEDAAAAASKEPLSQQKLHRKVLDKGVPEDVMPGILETQEPLPDYPLAGMLNKTGGKVRLTFKLEQDQLWIGTKERTDKIPMISIKDVHSEPIHDHPEYHIMFLINKCFPLQGIQLGTTEASRYWIYWVPSQYISAIKDAVLGKWCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPT0</accession>
    <name>A0A232EPT0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002897">
        <property type="protein sequence ID" value="OXU20364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPT0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="216" mass="24756" checksum="32FEE35A1679634E" modified="2017-10-25" version="1">MLLTPVTPVRDTWKQVILRSTMIDLTHAHWFPLVLQGNIYSLTIFRSPKGSNKVLMAYLNKKKNTMEILDDLDKLMNNNNKEEEADNETADKKRSKEKLTTDREEIKQLNKKCCLHINMKFSPLTSLPVGNFSEETENEYTSFTTDAINVIYLIKNPTSRAGAGSGSKFLIGHIWIRKMVYLDQSIFKKLKHRNTVRKLKSEIRHACVICAIGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ04</accession>
    <name>A0A232EQ04_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002849">
        <property type="protein sequence ID" value="OXU20445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ04"/>
    <dbReference type="STRING" id="543379.A0A232EQ04"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000017">
        <property type="entry name" value="Raw, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36300">
        <property type="entry name" value="RAW, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36300:SF1">
        <property type="entry name" value="RAW, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="498" mass="55534" checksum="435C605BF2144FB7" modified="2017-10-25" version="1">MPHLTETSLQLGKEPTTMFKEFFIFATELACLFNQGVSVPMSSSCSIHCDGKDTDKAGSSTYMHNVTSSQRMEYEVFLGGSCNPTTWRTDIAIPALQSLGITYYNPQVAQWGPELVAQEYEAKKTARVLFFVIDDRTRNTAGIIEAAGLAGTRRESLVIVIHPYRQGQSIFGETLSNQEYYELMNGLMVLQYLMERMRIPIFESISAALNCTSKIIRNAINVQDLHAEDGIRPPRISFGQHGTDVTKLREAFKSLDSGDTGTISLAEALMLLQNNGKCNNLSISDLRNVVNKADMHEKSVIEKLSSNGDNLREQRVNFEQFCAIASEWSWRFKNNGVNCENWTNSIISDTDKRDLYVGVVGKDLNWLESSAVPLVESMGLTLHRPSTNEYSARVLPLELQRMKNSRLIMLVIPHHARGIAIMALAAHLIGLRAKLVLCVQALPEGFSVSGEKLTEQAIKDYNRGRIYLSDMATREGVPVYENIGDALQHAIQIVQSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQD7</accession>
    <name>A0A232EQD7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002816">
        <property type="protein sequence ID" value="OXU20516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQD7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10446" checksum="95454203BCB3258E" modified="2017-10-25" version="1">MTLFTNTYKTQLIFKYLPNKISSGLDNIPPIVLKHLPVKIIKDNIISTTHALHKVTNDMNTHPHNGLVVGACLVDLENAFDSVWMFGLLFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQM4</accession>
    <name>A0A232EQM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002745">
        <property type="protein sequence ID" value="OXU20641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQM4"/>
    <dbReference type="STRING" id="543379.A0A232EQM4"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="69065" checksum="BFDC707137DA62F7" modified="2017-10-25" version="1">MSIVSSRVSSVSSILKGSGVRSALVNSQKRICFKLPRNLKTVLLNYENGCDRQAYQDMVCILRDSNVKDYELLELLNDLQECMSMLGPLHKLFIEVLLNINWTDRSSEIIASYKKFVEDLTCMHIYHLKLVIDKLIFQFRLVGEGATPWTSGKCPENYKNKISHIHDTLRKFLKIIPMSSDVLVQSLTSLYPHVSEGILPTQQYLFSLIQILDYAPQLRKDIFCLIINRLVALDVSVPPSEIQNCEDDEDMEEDENEAIFKLDDTNIENNSKKSHSTEMKHPGAQMLDVCMEQVLAYVYNCCHVEGQLQIDSLRIIYNDLLYTFERIILTTHASHHVQFIMFYLCSFKLTVAETFIRWLWQKVSNPNVAPIIRQSAVSYIASLLARATYVTVGLLQSVLLEMSTWIHSYISSQDSLECANSDVRVHTVFYSVCQAMFYLLAFRHKDIIDGKKHLLFLQGLNLTKIVTCRLNPLKVCQPAVVQNFAAVTRNYQLAYCYTVIERNSRSNLPVLQTTNRFINWLDTFFPFDPYLLVLSGQRITPLYNNSQCTTSNTTESYVSRSSKSECDEDDFMDESFTSQSLDSQNHFDKFSYSTSPGFIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQU2</accession>
    <name>A0A232EQU2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_014182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002707">
        <property type="protein sequence ID" value="OXU20735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EQU2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="850"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="131"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="444"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="729"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1285" mass="145750" checksum="54C2CC3814350463" modified="2017-10-25" version="1">MEKKKKSRNLSPRHKANCFSRFVFCSRLYREENSQVGLKRTMLKRGQSPRGGNLQYLKPLLDCVRSGKVRASHLSFDSPSSDRSELLGNKLEAKWKKEVEDVAKAESGGPRLWRAIFWAFKWYFAQHLLQVIFLELIVSVVQPLLIVSSLDYYRLHSEPIPISHISSRGAAYAVLLSLQALLASHVRLQQRENGARLRSACASLIYRKITRLSCSSASQTTSEAIIRLLEGDVKNFDKFFAYVHNIWVTPLQVIVVTCLMYNKVGASCLFGILLLLLQGAPVRLYSNKVATGFQSKVASWTQERISITREVLRKIREAKIFCWEQLIEKSLYINRHYEIDILKIASYAKGLKLAVYVFSEYTSLFSVILVYTLLGYTAFEHEKILLVALYVYVLHESMIFTFPKAVTTLVQANGSVKRIEQFLRLEEVEPNLALSMLSNDDSSISVKDVNASWAKNANVNLLESIDVCVPPKKLYGVSGPAGAGKTSFLKLILGELRPTSGEISVNGSISYASQEPWFFFGTLRDNILCSEVYDELHYRQLTAMCGLDQVFEILPKGDETVMLSGETKLTDEQQMKINLARALYREADIYILDEIFTVLDDKVFEACMNGVLKDKTRIIVFEQDSPLLMLVDEIILFDHGQIEFQGTYESYEQSSMFVEPQNRKIEASAVEKTDVIRVTTSPLNTYHHQEKINEKEPDETEKLLTKSSTSDWLYCWYLKTGSSHVALGFSLLFCILAEAFVCGSDYWLGYWTDHWNKPRQSDGDYLFYVYSVLAVGTVAFFALRNVIFLKICLDGSEKTHNKMVSRLLRTPMRFFYDNPPELVLRRFSDDIGRIDNNLPEAMLEVSHISFALFGASLLLAVINYWSIIPICAIGFLYYRLTCLYASTIPKLRLLEHSASKKTLSQVESTISGLPTIRNSRAQRLVLRGFSARQDSRSSARNLVLSSIAGIRFWLDLLLTILGALVVVGFLALKEKEDTSSTRIETLAGIALTFKQFMVIARMARLGLKASAKVEEQKERIQKIVGYIELELEALYENEAKEKQLKSWPSKGEVKFDHLYVRYSESDEPILVNLDFTIEPGSKVLVIENAESQKSSLTSALYRLAEIEGSLIIDNIDCIENLSLHRLRQTIAYVTQESVCLAASSSPRDILDPDEEFKDDDIWDALELVDLKRSFASLDHSPFKRKLLSLARAALRKSKILVVDETAVTDDSDEVLQRLLKDNFADCTILTIAYKSRVPKLHCDKVVVISEDGEATEYECRDGVMRNNSIVLRSLTSPTIKILYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER23</accession>
    <name>A0A232ER23_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002677">
        <property type="protein sequence ID" value="OXU20798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER23"/>
    <dbReference type="STRING" id="543379.A0A232ER23"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="186"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="263" mass="29452" checksum="E814DE3E2E4C751E" modified="2017-10-25" version="1">MADISKDELRKEITAILKDADLTSMSAKKVRQQIEEKLDVDLTERKKEIDDLVMECLQEKQDSGKKKKTTSDESEDGEEEEEEEEEEEEEEEEEEEEKKPAKRGPPKKTAAKRKKGSSDEEDSASDEDASDEEYSPKKAKPAAKKGKAGKKGKKGKGGDSDSDSDWGKSKKSSGGPKKGGGGKGSGYTRAITLSPELAALVGAKQMPRYEVVKKLWSIIKERKLYDPKNKQFAICDDDLFKVIGVKRFRTFGMMKYLKDHFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERB7</accession>
    <name>A0A232ERB7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002666">
        <property type="protein sequence ID" value="OXU20826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERB7"/>
    <dbReference type="STRING" id="543379.A0A232ERB7"/>
    <dbReference type="OrthoDB" id="4752984at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF190">
        <property type="entry name" value="RING FINGER PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="311" mass="35886" checksum="633BF0256638BF92" modified="2017-10-25" version="1">MTALASLASLTLTRSRVTRRVLARMFGPLDRAENGLLKMRNFSAMAEQLLFFVLADKLLLQPRQRMTGLYSLMFYNVVAYCISYVKELVSKEDWSPYVTLTETSQIKHLAMSATKIVLEWTKAVTFLVTVTFTLLVFGLEQGLQNYKPSIIYTVVTWAYYTATEKVFIDMFPSVLRFLEIEALESLENLYAPVILRVFTITLSTFFILLIVPIVPWRLLFVAIYFNVYLRSKELIQTHWTALKKESEILAKYRHATPEEIENFDDVCAVCISPMKRARVTPCQHLFHASCLRECLKTSDCCPMCKRLLAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERC3</accession>
    <name>A0A232ERC3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002648">
        <property type="protein sequence ID" value="OXU20872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERC3"/>
    <dbReference type="STRING" id="543379.A0A232ERC3"/>
    <dbReference type="OrthoDB" id="8117569at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012986001" evidence="2">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="242" mass="25609" checksum="3086010F9C73129E" modified="2017-10-25" version="1">MEFPVTFAILLLCASSCLAKPYHRPPGYYAPAPVGHDGRVVDTPEVAQAKADHLAAFSKIAARPVALYPGADHYTAGAAPAAAYGPYSNPGYFSSRIQHGAYPYRGPPAPLAHDGRVLDTPEVAQAKAAHFAAFSQAASRVYDVPQASNQNAYHHQQSAEDYDSGAYHANNDDDDGSGSAEGYYDGQASVPYQGPPAPLAQDGRVIDTPEVAQAKAAHLAALQRASSQQAAYTAPRPYYADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERR5</accession>
    <name>A0A232ERR5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002559">
        <property type="protein sequence ID" value="OXU21048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERR5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9522" checksum="329F1AB654712A5F" modified="2017-10-25" version="1">MSQEKKKYLFSNAPFTNHARRKMRSTIKNTLFPNTDIPHATNNDLLENTDQLSDNEEDMNVEMSVDYGATRLLQELCRTLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES81</accession>
    <name>A0A232ES81_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">chymotrypsin</fullName>
            <ecNumber evidence="7">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_011693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01002501">
        <property type="protein sequence ID" value="OXU21177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES81"/>
    <dbReference type="STRING" id="543379.A0A232ES81"/>
    <dbReference type="OrthoDB" id="10061449at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008732" description="chymotrypsin" evidence="9">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="272" mass="28848" checksum="0943345B6A4241F7" modified="2017-10-25" version="1">MSFKLVLLTSLLAVAQAIPFLGFDARITGGQAARKAEFPYLVSLQRGDPPNVAHFCAGSIIKPKWILTAAHCVTVIPAGGTLIIKAGKYLIKQVEKDEQVVEVNRTIVHEKYPGNVAPNDIALIKLKTPLKFNGNVAAIKLPEANSQPTGVFTLTGWGSVSLNSKPSYPNVLQKVDVTLVDLYTCKLSIEKITGSAPLDQGNMCTGPLSGGISACSGDSGGPLIGRDRNGTVELVGVSSWGVKPCGLRGAPSVYVKVSSYIDWINKHIGKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES96</accession>
    <name>A0A232ES96_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_000872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002470">
        <property type="protein sequence ID" value="OXU21228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ES96"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000512">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="761"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="958"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1087"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1254"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1291"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1316"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1352"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1384"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="14"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="466"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="956"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1433" mass="158468" checksum="CA830FA096F158BC" modified="2017-10-25" version="1">MLPTWAGCCVRIQQRWIFAIMGFLALFNAYAMRICLSIAITEMVVPLNITEEFIDDTCSELASKQLTNVTTAHGSGIYEWSEYTQGIILSSFYWGYVITHLPGGLLAEKFGGKYTLGIGIFLTAIFTVLVPIAVKWGDSTALIILRVLMGFSGGVIFPALNVMTAHWVPPQELSLITAVIFIGVDLGIIGATTISGLILRYSLIGWPGVFYFFGGMGILWFLLWVILCYNDPEEHPFISEKEADYLREALEEYTHKNTPSVPWSYIFKSPSFWALLAVQIGHDWGLYTLVTDLPKYMSSVLKFSVEYNGYLSSLPNLCSVLYCLFISWATDKMITSKCVSKTNARKINTTISTIAPALFIIGASYAGCDRVAVVIMFTLGVTLMGSSLPGIKVNSLDLSPNYAGTLMALTNGIASLTGILTPYLVGVLTPNQTLSEWRLVFWIVFCIFFITNTIFILFASGVNIPQRWIFALMCFFALFNAYAMRACLSIAITEMVVPTTIAEDILDDTCPAMDVEVPSNETVQIKGTYEWDEYTQGLILSSFYWGYIVTHLPGGMIADTYGGKYTLGIGILLTAIFTILTPVAVYWGDSDALIILRVLMGLGEGTTYPAINVLLAQWTPPEERSRTGSFVYAGALIGTVYATTVSGLILHYSSVGWPMVFYVIGTTSIIWFVIWLLACYNSPRDHPFISKNEVDYLKERMSEHTHEKPPAVPWRHILASKPLWAVIIALIGFNWSILTIVTDLPKYMSGVLKFSVQNNGYLTSLVYLCMWIGGTISSWLADYLIAKEFMSMTKVRKIGSIIALTCSAIFIVAASYAGCDRALVVGMFTIGMTIMGFAFPSVMVNALDLSPNYAGTLMALTNGISALTGIASPYIIGIMTPNQTLSEWRFVFWILFGVSSVSNLVFLLYGSGEVEYWNDPEFVNAEYERRKKKSIEEVRVAGLLDAWRSCCVNVPQRWILALMGFLGLFNAYAMRACLSITITQMVVPIEHSNEPSDYTCESTENITSSGNSTIGSAGKGSYEWSEYTQGIILSSFYWGYVVTHLPGGMLAEKFGGKYTLGIGILLTAVFTLLTPNAVAWGDSTALIVLRLLMGLGEGTTYPAVNVMLAQWTPPEERSKTGSFVYAGAPLGTVYATTVSGLILQYSSIGWPAVFYFFGSVNVLWFLVWVVLCYNNPREHPFISESEVKYLNERLSDHTHQKPPPVPWRHILTSKPLWALIIALIGHNWAFLTIVSDLPKYMSSVLKFSIQNNGYLSSLAYLCMWLGSLLTSWIADWLIAKGHMSMTGVRKLGSTIALIGPALFIVGASYAGCDRVMVVVMFTMGMALMGTALPGIMVNVLDLSPNYAGTLMALTNGISALTGIVTPYIVGVLTPHQTIAEWRSIFWIVFGVSIATNVVFLLYGSGEVEYWNDPEFVKEERRRRKNKNVEEIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESL7</accession>
    <name>A0A232ESL7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002429">
        <property type="protein sequence ID" value="OXU21286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESL7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="40" mass="4951" checksum="8CC2CA07295D09D4" modified="2017-10-25" version="1">MWWRPWRDDRVSALQARESQFKPGVRHFFVALFTRNKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET64</accession>
    <name>A0A232ET64_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002329">
        <property type="protein sequence ID" value="OXU21543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET64"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="10285" checksum="6795658E3E26A57E" modified="2017-10-25" version="1">MFYYQFFTSGSIYSAGEYASHTRQPIINELRNALFFLLLKSERVKNKSKSVSLCELRKRTTIKCEMIMIRRASSTIRKRMCKSLDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETR0</accession>
    <name>A0A232ETR0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002243">
        <property type="protein sequence ID" value="OXU21743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETR0"/>
    <dbReference type="STRING" id="543379.A0A232ETR0"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000445">
        <property type="entry name" value="putative inorganic phosphate cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000067">
        <property type="entry name" value="sialin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="499" mass="54444" checksum="00626B764E4404A3" modified="2017-10-25" version="1">MEVLDPSVSRDDQPLCLNDSLQKVHPSGGPIADSRSCVKSRQIFGFMGFLGFALVYAMRVNLSVAIVSMVNSTAVPNPDNGTIVIDDCPKTTPVNQTFPPSEGEFDWDEKTQGIILGAFFLGYVMTNVPGGRVAEKVGGKLVYGLGVFLTAVLTVISPFAAYWGLYPFLIIRIAEGFTEGVTFPAMHSMLAHWVPPLERSKFAALVYAGSNFGTVISLPLSGWLCSLELWGGWPLSFYLFGGLGIIWYAFWLMLVYDTPAKHPRIDPQEKAYIESLVEPKDENNTAGVPWLSVFTSLPMWAIAITQCGQSWAFYTLLTELPTYMDRILHFDVQQDAFLSALPYLTAWITGLIISSFADALLARNIVSPLTSFKMWNTVASLGPSLSFLGAIWAGCDRLTVMMMLSGLGSLYGAVYAGNQMNHIALAPRYAGTLYGITNAAANACGFLAPYVVGQIVNGHETLARWHTVFLLAAVINIGANCFYLLFASAKEQPWSNGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU13</accession>
    <name>A0A232EU13_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002192">
        <property type="protein sequence ID" value="OXU21842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU13"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7434" checksum="1D74BFAFC15E8371" modified="2017-10-25" version="1">MQPLQKIASKSSYSRKCLQKAATPENVFRRQPFQKISSGGSYSRKRVKKQLVKKIVQQPDSFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUC2</accession>
    <name>A0A232EUC2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002139">
        <property type="protein sequence ID" value="OXU21953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUC2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="277" mass="31865" checksum="8B211D705E6BA676" modified="2017-10-25" version="1" fragment="single">LFITKVNKENIITKLQKKKRPHPVFENSLTNIPRKRDKETEMLFRKETEILIRWLTQLNKDDTISDCIPFTSILPNVRMAKSGASLVSNNTPINIPANIENYSSDDSLGPNITKDPWESCRNKHKKTKKTKNTSLPYSSNAQKLFNRYALRVVDYNHTLTNSKNISAENSKSKQNVSWTQIPTIKRRKPLRPTSLHRSLSLVTMRIICHLPPIHSTPKSPRKNKKVKRHNTPGDLSPSQALPEIATEMHAKLRVNIKEKEHNGKINIQVDIWKTDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUM4</accession>
    <name>A0A232EUM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002107">
        <property type="protein sequence ID" value="OXU22059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUM4"/>
    <dbReference type="STRING" id="543379.A0A232EUM4"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19577" checksum="40E5A1C67BB8EFCD" modified="2017-10-25" version="1" fragment="single">AATHGSIQEVVHSMARMNAISRWSTMVRPFIALQRFSTTCPVSSKDQYDLNHPEGREPSIPLYTEREGENVSVKKARLLYQSRKRGMLENGLLLSTFAKKYLDHFNEEQLKQYDRLINLPSNDWDIFYWAAEVKPVPPEFENEVMDLLKKHIKNEHREARITQPDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVA6</accession>
    <name>A0A232EVA6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002021">
        <property type="protein sequence ID" value="OXU22292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVA6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="96" mass="11332" checksum="726936C70577BB8A" modified="2017-10-25" version="1">MIVGSLEEKLRASDLRIQQGKKRRRLHNKIIRKTINHFSWLKRRNGFPMTGKTTWRNKTSRRGRKTSRGISDNNGKSAVQLPKRNEPSLRVYTMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVB8</accession>
    <name>A0A232EVB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002016">
        <property type="protein sequence ID" value="OXU22302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVB8"/>
    <dbReference type="STRING" id="543379.A0A232EVB8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012646934" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138248" checksum="30DE52399F713679" modified="2017-10-25" version="1">MIDKTAMASMTKCILLTFSILLARSFAQNNGFFGISIIGNFFQAIKNLLRFSIGGLDFLVDFARYSHKEFPDSTPENGDEYDFIVVGAGSAGSAVAARLSEIEDATVLLIEAGANENLVMDIPILAPFILLNKFTNWNYLTEKSDNYCRGMVNQQCKINKGKVMGGTSSINFMLAIRGNKNDYDTWYNMTGDENWSYEGMLKSFKKMETFDAPLVNADPQYHNFNGPQRIANPPYHTKLADAFVEAGRELGFHPVDYNGEKMTGFNYVQATQINGERMSSNRAYLHPIRDRKNLVLTMNSLVTKVIIEKYTKTAVGIEFIKNSNKIRVKAKKEVILCAGAIASPQLLMVSGVGPAKHLESFNIDVLADLPVGENMMDHVAYGGLTFLVNTTDGIVVQKYLSPTDPSLQLFLTKRKGELTTTGAAEGLGYLNVDDPWVHNLEPNIELMFATGTFLSDSLIHVPFGITESQFIQFFASNLYKHAWFIWPLLMKPKSRGKILLKSKDVKTQPRILANYFDDPDDVRVSIEGIRIAIKVSKTQAMQKYGSKMIDKPVPGCEGYKYDSNDYWECALKTYTMTLWHHSGTCKMGKKDDKTAVVDTRLKVLGINNLRVVDASIMPEIVTAHINVPTIAIAIKNLLRLSIGGLKFLRDYARYSRSEFSDSMPKSGDEYDFIVVGAGSAGATVAARLSEIEDAKVLLIEAGGNENLIMDIPLLALYLQLNKPSNWAYLTEKNENYCRGIVNQECKVAKGKVMGGSSSLNFMIAVRGNKHDYDTWYNMTGDENWSYEGMLKSFKKMETFDAPLVDVDPAYHNFDGPQRIANPPYRTKLADAFVDAGKEMGFPPVDYNGEKQTGFSYMQATQVNGERMSSNRAYLHPIRGRKNLVLSMNSLATKVIIDKDSKTATGIEFIKNNKKIQVKAKKEVILSAGAIASPQLLMVSGIGPADHLKNFKIDVLADLPVGENMMDHVAYGGLYFVVNTTDGIVVPEYLLPTNPSLQQFLTKRTGEFTTAGGIEGLGYVNVDDPRADNLVPTIELMFGSVSFLADYLIHVPFGVTEKLFSLFYAPDLYKHTWIIWPLLMKPKSRGKILLKSSDMKVQPRLLGNYFDDPEDVRVLIKGIRMAIEVSKTQAMQKYGSKLVERLVPGCESHKYDTDDYWECALKTITITLWHHSGTCKMGKKDDKTAVVDTRLKILGFNNLRVMDASIMPEIVTAHINNEVRDEVYSPYYQRIISNGSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVH1</accession>
    <name>A0A232EVH1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002007">
        <property type="protein sequence ID" value="OXU22328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVH1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7296" checksum="3C80C7C6C99ED9C6" modified="2017-10-25" version="1">MPICSRICSASSEKAGHFWGSEPTFLRSLGHPEPEKPWVPAITKYLFFYGHFKFSYGNLTWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVM2</accession>
    <name>A0A232EVM2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001980">
        <property type="protein sequence ID" value="OXU22391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVM2"/>
    <dbReference type="STRING" id="543379.A0A232EVM2"/>
    <dbReference type="ESTHER" id="9hyme-a0a232evm2">
        <property type="family name" value="SERHL"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="294" mass="33777" checksum="A08A1EB0F3332B00" modified="2017-10-25" version="1">MTNPGKLTLNVPWGHIAAKTWGKPEDTHVLMVHGIMDNAGTFDRLVELLPQNFYYVCIDLPGHGLSSHFQPGVPLNYVSYVLAIRYVLDELRWKNTYYIAHSLGAHLGLLFAIVYPERIRKLILIDGIIARPIPNAELISRIREEHDLAIKAYKLKNPRHYTKEDVMYALGNLRKCCLSTEAAKKIFDRSVTKVGDNAYCYNRDYRARISIIPNFNKDQTLYLLSQLKVDTLIFMATDTLPFIKYLKPDVIEELKPKKNVNIIEIEGNHDVHNNYPHRVSGHISKFLCHIPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX96</accession>
    <name>A0A232EX96_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_000987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001761">
        <property type="protein sequence ID" value="OXU23001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX96"/>
    <dbReference type="STRING" id="543379.A0A232EX96"/>
    <dbReference type="OrthoDB" id="6125763at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11416">
        <property type="entry name" value="bHLH_TS_ceHLH13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000035">
        <property type="entry name" value="Pancreas-specific transcription factor 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF97">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="136"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="278" mass="32151" checksum="BC9B0BC62FE6DD12" modified="2017-10-25" version="1">MASHPVFDYEDRTQRMRHRVGVATAKPADSTVACSSRFLSSQYYLGPSSDISEEDIADLPSCVFANRPSQQQQQQPQHITHASQQQQQQQQQQQQHTHSPLHYHVPVTTPVSDHTENDVNGVEEGYYPNGSPYRIQRHAANIRERKRMLSSINSAFDELRIHVPTFPYEKRLSKIDTLRLAIAYISFLNDILRSKQDPITHIMRCLRGEFNRERLEWNTSGKFELSTFYYIFNLSTLHFAPIADLTARLSWIKWENLGVNPNQRSVFTSLTLTTDNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXK5</accession>
    <name>A0A232EXK5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001736">
        <property type="protein sequence ID" value="OXU23083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXK5"/>
    <dbReference type="STRING" id="543379.A0A232EXK5"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1277" mass="146519" checksum="BC514EA7BD97BA8C" modified="2017-10-25" version="1">MALSTGLIRRLDSSDEPLPKRLKLAENVFYSPDLPIVRKEECIFRWLCNAFSKENSSAIWTTIHRCLSLEPKNFTRLSPETKNLLIDKLVASLIEYPQTQVTNEMLMCGSYILSTTNIQSYTKDNKVVALIKTLLLFTNKVLNLSGETENKSENCIGAVDCAEQAVSTFAFICRQNLSEKKNLITIFIEEIFFPLSVLVETLKLKKVSSKIVVESQKCIKRLLLGGIKNINLTNDEKNANAEESEVIFDILRNKVSASKLENITEAFICLFQCAGNTFQQNSNLMDIILRKLVETVEQKEHSKKVLICLLENSSDISYNFDHEIKGVSLKVYLKQYIEEIVSKKKRFKSFDYELLCAIAKLNPLIVEDETQAMLERILFEDKSHDKEMAAYENLLKELWKASVRLRRQQKFLSKFLLSISKYQDKEVECLEFKNEFQLPDNFITEFIEDLKSRTTSAQVISIFHTLLFHLKSDCIGKLKTSGPTAQVCITTKIIAKLLVVYFEHSHFLDSSLPKDWQNKFYQVFTDLRNTLALFCEVICETSVKHEEISFVAFSDIVRIWCETYDLLRYYLENSASDKLDFPVNESQFKELKQIIKKCKHHNCEESLDQLCLLNSIVYNHDNQLVLKDKVITHLWSPILENHFQLLESFNETQILNLTSHFVEEASRNHETLNKWKSISRNIHRMTKMFATAMALQIVSYTVKDVEVSTTKTIIDKVDFGKLLISLRDSDSLKKVLKPARKEILKQDIKSSSPVDSDKTRRNLILLSSLPISYLDTSIRSFLFMVLYTLEKETIKNPDLKELFTNLYLDLLRQNDVDIMSNVSNPVILINHFKDNKPVLLKVFKSSLTSLAALSFWKEFISTEECNKTISCILLSCIDSSKNKASTNEHKSLLHNLSLKLSSKIVRELHEGISDPEEISGVRVSLKVILLEKKKLKSSLKNCIEMTLKKVVENSEKADNRLIHESLQLSLVTLSNRDKFDINEDVVKKLCIILIHNPDGKIFSHFLEVLKDIEFDYFAKTLNNETKKGLAEGDASLLDKLITIWESLSKAETKAIRSKSLCTSVNNLFNELIASDIREISSVFLLKMCRAIVASKRMIRLSDRLVDSIFVTSTQSLNELCIDTKFIACQEALGLCLDFIRSKTDFLFDRLPALTNLFRKIIRIILHEAKDTNFSDEQMLRILAVDIEKFCTFFAKLKKDVGRISPYLIADIIDASSQAGVLPSFLKVSIDSSLSHLLSNCDRHAISFLSRTLPVSTQQVFKTIYDNYIKYHKFTGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXY8</accession>
    <name>A0A232EXY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein LLP homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the learning-associated protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001697">
        <property type="protein sequence ID" value="OXU23193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXY8"/>
    <dbReference type="SMR" id="A0A232EXY8"/>
    <dbReference type="STRING" id="543379.A0A232EXY8"/>
    <dbReference type="OrthoDB" id="6257894at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001099">
        <property type="term" value="F:basal RNA polymerase II transcription machinery binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097484">
        <property type="term" value="P:dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018784">
        <property type="entry name" value="LLPH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253:SF1">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10169">
        <property type="entry name" value="LLPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16339" checksum="C82470C5CADB0F90" modified="2017-10-25" version="1">MAKSLRSKWRRKCRAVKRVRYGEKELARLKKTLGIDENASNDADMSDIQEIATVTDAKAIKGSKDKENEVENVEEEKMDDGTARVYNKKTLRDQYGNYPVWMNRRKILKHKKGRAKSQKATTKKDKHLTRKDKKKEPTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYH5</accession>
    <name>A0A232EYH5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_014814</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001687">
        <property type="protein sequence ID" value="OXU23228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYH5"/>
    <dbReference type="STRING" id="543379.A0A232EYH5"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15285">
        <property type="entry name" value="7tmC_mGluR_group1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="365"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="808"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU23228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="911" mass="102136" checksum="C8EDBF8DADA5B7A7" modified="2017-10-25" version="1" fragment="single">NYGTSGIQAFRELAEKTGVCVAREDSILTSADDAAFDAVIQNLDQDRAANVVVCFCEGFTIRHLMEASKRMNLTGRFVFVGSDGWADRDDVVHDLESEAWGSLSIRIHSPYVAEFDNYYLSLHPYNNTRNPWFNEFWQFNFNCSLPVEAEKDSRYKLPPNFPNCTGEERLTYERYRQDPKMSFVMKSFWVMAHGLHNMLEETCGHNYTGVCKQMFPFNGTRFLHHLMNVTFAFGEEFVEFDRRGDPPGRYEILNYQLMPNGTYAYVQIGDWNNGTLTLTGWPQSRSPSLVESVCSKPCPPGYYKNFKTGGQEKRCCWACVPCDHDQYADEEQSKCIPCPQGQLPNKNRTACYVIPEEFTLWTDVEAIIAMTSAAIGLLATFVTCHIFIRHNNTPVVKASTRELSYLILAGMTLSHFSVLPILAKPTYTSCTLSRLMPGISFAMIYASLFTKTNRIARILAGSKKRFPKRKPLFMSATAQIMITCILITIEVAVAATMLMMEPAMPIRVHPARDRTVLTCATTPRAVLSPLAFDALLIGLCTLYAIKTRNVPENFNEAKFIGFAMYTTCVIWIAFVPIYFGSETKRLFKDAKLSQVITMCMCVTLSASVTLVFLFMPKLYIIVLRPDRNNRALFTTSKSIRCHIGARVAAAIAEPTPKHAVYRISESEETESSSAYRSNSSSTKRRTLSTQTDKELLMSLCQALLLGTATATAGKASPVKSIDDHQQQPTKQLMWECEATVEYDEACEECNGLRRASMEKSEASQTSIAYARNHRGESVSYERNHWAELDVKRLVDDLRRRSVAAYPSARSNCHRGPTSSFATGASSSPIGRKRMNGLRGADYELHQLGSRDSNSAESGAIDSEPLRLIDLRARIREESELQPSDSGDPVINITITLGHGLPDYVDAPVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYU8</accession>
    <name>A0A232EYU8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_005129</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01001595">
        <property type="protein sequence ID" value="OXU23479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYU8"/>
    <dbReference type="STRING" id="543379.A0A232EYU8"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14091">
        <property type="entry name" value="STKc_RSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05582">
        <property type="entry name" value="STKc_RSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000010">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000013">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001170">
        <property type="entry name" value="Ribosomal protein S6 kinase alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041906">
        <property type="entry name" value="RSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="70"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="327"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="424"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="76"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="430"/>
            <end position="438"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000606-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU23479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="745" mass="84644" checksum="E45307194361F0C3" modified="2017-10-25" version="1">MPLATLTVPWNHEQVNEKQTSEILSAESQEEKMIPRSSVEAHSNGCSESHEIEVRDLVRDGHEKAEPRHFELLKVLGQGSFGKVFLVRKTVGKDSGTLYAMKVLRKATLKVRDRVRTKMERNILVDVEHPFIVRLHYAFQTEGKLYLILDFLRGGDLFSRLSKQLMFTEEDVKFYLAELALALDHVHSLGIIYRDLKPENILLDTEGHIALTDFGLSKQPLDDTQTYSFCGTVEYMAPEIVNRKGHSFAADWWSFGVLMFEMLTGALPFQGANRKETMTQILKAKLGMPQEISPEAQALLRVLFKRNPANRLGSNGIDEIKNHIFFETIDWNKLYKKEIKPPFKPAVSQEDDAFYFDNEFTCKTPRDSPGVPPSATAHELFRGFSFVAPCLLDDREVYAEHKPSENVTTTFPTYVNPTCITDEYDFKQEIGKGSYSTVYLAVHKATKAEYAIKVIDRKKRDPTEEIEILLRYGRHPHIVTLRALHEDERHVYLVLELLRGGELLDRMLQRRNFTEAEAAEVTYTITSVVHYLHENGVVHRDIKPSNILYAKTGFNPSTLCICDLGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYIMLSGRIPFPNTPGDTANDILDRIGRGYIDIETGVWCQISTEAKELVKRMLHVDPARRPTAANILKHPWIVNRHRLPLNLLPDITKDPVTVKNAVAATYQAMSNSPRLPNIGPVVMSELARRRTQAKLSANIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZR1</accession>
    <name>A0A232EZR1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAR3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001480">
        <property type="protein sequence ID" value="OXU23819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZR1"/>
    <dbReference type="STRING" id="543379.A0A232EZR1"/>
    <dbReference type="OrthoDB" id="6264899at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23058">
        <property type="entry name" value="PDZ2_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23059">
        <property type="entry name" value="PDZ3_Par3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000011">
        <property type="entry name" value="partitioning defective 3 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052213">
        <property type="entry name" value="PAR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021922">
        <property type="entry name" value="Par3/HAL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484:SF17">
        <property type="entry name" value="BAZOOKA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16484">
        <property type="entry name" value="PARTITIONING DEFECTIVE 3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12053">
        <property type="entry name" value="Par3_HAL_N_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="186"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="323"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="471"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1252" mass="139163" checksum="31272011F94317FD" modified="2017-10-25" version="1">MKVTVCFDHIRVVVPCGDGSLLVRDLMHEAMLRYKKATGKSDSTLTINSLSSLTGGGILDPDDRLCDVADDREQIVAHFAGSDVVHAGGDGASSVGTNSPDFFHTDTKEHRMYTSRSTGNIKRESTKRLSMHVLSSREPCLTTYSALSLPRESRRKEPLGQDAKALYEIPNLKPDLLDQGEICEIIIKNEAGPLGLHVVPCYDLLGNDQGLRVEGIEPNGRIAKDGQIDLHDKIIRINGHNLLRIPFSKVQEIFRSCMNDSCLKISVLKHKKSPQDKNIQKTLGTSSSSEKTGENDDSIKRLQCANYNVLQTANTRKIGKMIEIELTKGNNGLGFSVTTRDNPAGGHCPIYIKNILPKGAAVEDGRLKPGDRLLEVNNLEMTGKSQAEVVALLRSIPPGGKVRLVVSRQEEVCANTSDTPDTSKNWKSPQDSPTKKKEEAEAYDKCNYKTVQVANDVVLSPRKNRMILTLDIPVHDSEKAGLGVSVKGKTSTAEDSSNTDLGIFIKSVLHGGAASRDGRLRTNDQLLLVNGVSLVGLSNSDAMETLRRAMFNTNSSITGVIQLVIARRLSSYDTSSNSEKNFSDKISPSTCKDSPSSVFIMNSNTKQNDGHVKEKNNLNSQTDILDNSLLAASASPWNPVIDRLTEQYNKNSLRNESYCIATNKTWMDPVSIAKKLSIGQRDDHLKSVLAEESNENSHSSNTEPKKSADDKDSQYSGDPAYDSQLSLEEFTSPTNKFSRDALGRQSMSEKRHAALDAKNTDTYKRNKKIREGRDNNNKSDEQKNHSKDYKADSFGTTNSSKSSIGESSKHSQPEYLYTIPGPGCNNKLTLPRKHWLVDDVHTAEVSNSSNNKEDQGFTNTRGDIKQASLNSALDDRYKRSRRKGIRSMLRLGKNRKSLNFGDNIENRHESTFQPIRTSVFTQQKRFRGKINIQRPRPPHHERGKVLKFSTPFISNPDTPKPLKERCTRISQMDVQKTKPINPYDVIIARECLNWFKTSRMVAILHANSIKSEQQFEYAVPLKRANMYFKGYQASILNLALKDSNYEAVLKLCLPTMPVSYFVFSPETNVPKLVQITKKTPQLILMAGILDGKFLRLNDFIKYGSLDLVTAQAGLVQVLRTAAGGNLNQQLTHHQSTLVTRLKQICTKEEDKPCDANDNIHCDTIDVPGHRNVTFFVQDIVLFKLSQQIKRYVVIAHLADRTEEVVDIVVVNAPSWAVGCFAVESVLAGVVLRLSYGFGEVLLVDFGRDELQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZT6</accession>
    <name>A0A232EZT6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_000367</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001454">
        <property type="protein sequence ID" value="OXU23921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZT6"/>
    <dbReference type="SMR" id="A0A232EZT6"/>
    <dbReference type="STRING" id="543379.A0A232EZT6"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="14">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="13">
        <location>
            <begin position="109"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU23921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="193" mass="22492" checksum="F25A71ECA1694289" modified="2017-10-25" version="1">MVNGRIPSVFSKTYVTPRRPYEKARLDQELRIIGEYGLRNKREVWRVKYTLAKIRKAARELLTLEEKDPKRLFEGNALLRRLVRIGVLDEGRMKLDYVLGLKIEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSVKSPFGGGRPGRVKRKNLRKGTGAAAAEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F025</accession>
    <name>A0A232F025_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001504">
        <property type="protein sequence ID" value="OXU23768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F025"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6651" checksum="A6664189B4F17028" modified="2017-10-25" version="1">MIRRSKIAAIPCSKLRILGTHLCPGQLVVSVDWTTTGTPPNSPDHRVNKARSTEASTFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0A0</accession>
    <name>A0A232F0A0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitotic spindle assembly checkpoint protein MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_001443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001435">
        <property type="protein sequence ID" value="OXU23983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0A0"/>
    <dbReference type="STRING" id="543379.A0A232F0A0"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="123"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="280"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="375"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="79646" checksum="C052E2B43FF302A0" modified="2017-10-25" version="1">MDDQNPTRISKMIREMRAGTDGLQRSRSNSNSFSLRPDNIQRLSTANEGGESIFETPKRQKLEDSASGSLNKTDSEVPGSPWEWRRMKGELIGMKTRLSHQEATVQQLHKLRHEMEESFKKEKKLLEIELEQDKRMIKQLELRVDVGRKTVQEAKAAQAQAERELSQLRTKMEHKILSLVEDNNKLTEELRLCIKKEVKPDITKPCETSVRNIEDEKKLELAHKKITELEEKLREARVIQQKFEVQCVELHSLKIKYESLESERSMVEDGKKFMQRASKVSELERELSHARDLISSLRESVKGKLLLEEQMATIEHRLQRTENLEKQVSQLEITQSELLSKIAEYEAIGIPGGPIAIRREINRLQQSEAILTAEEGQLRSQIDALKRELETTKQKHEETKKLLTDTTSSQERLSRFVSRLQKKMSLVTRERDSYRQQLDTYEKEITAYQSNETPTVTNERIPMLERAIEGYRELVAKLESDLEACDGKGQKEENKKLKAEIERLKGELEHRALKGDFNINTRILHYKLNPLALAEQEAEAKQNALLQEVEQLRAVVASGNPSGVPAVSSSLQAKEIAELQQKHEIKIARLKEAFKASSQEYRQACYQLFGWRVDRTKEGQYKLSSQYADSPDDYLFFIVNDDGVNMIETPFSATLTAFIERYLKIQHSVPMFLNAVQSELFDQQTVANVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1S1</accession>
    <name>A0A232F1S1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001290">
        <property type="protein sequence ID" value="OXU24470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1S1"/>
    <dbReference type="STRING" id="543379.A0A232F1S1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="312"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="538" mass="60495" checksum="9A4A77FCBA6179A3" modified="2017-10-25" version="1">MEHPNFSPENLRWFHDACKRNDLELIKQFVEQGYPVNSRADSSFGDEFADYTPLHFAVKNENPEAVMYLLHYGADISKKSANSWSPVHLAYYVSSINLLPTIFDYSEVNTYVNAVDDRGLSHFHICCRTMDDPSYVGRFIDRGADVNQKTLFLSSYDSGFTPLHFAVLRKEAEANPILTLLLKNGADHSLKCEDGLTPLHLACKLDKVCSGMLLLLSGADIVARDDKNRLPLHYIFYRNCTSYLADVIFENIPTDRNYRDFQRLSLLHMACFCGKMSLVDSLLAQGCCPNGRVIAINENGKELLFAGKLSLAGLTPLHMALIESRWMIAEMLLLAGADINAEDDRGNSPLWYSYTPLGFRLSREVIVYPSKVIVAKHVMACQAAGLISAKVKRESLQCGLVASGTYKYMFPGCRAQLERIEMVRIKNGPVECNNLRGILGKNEFEMAKLLTNKSVASWLSPNYLDQLTKIFLVYGYMIKAQVNKGFRRIEKLLEAVDALERLTVARLPVPCSEQILSCLCYDDLESVIEASIAVQEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1X1</accession>
    <name>A0A232F1X1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001280">
        <property type="protein sequence ID" value="OXU24510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1X1"/>
    <dbReference type="STRING" id="543379.A0A232F1X1"/>
    <dbReference type="OrthoDB" id="10004364at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF27">
        <property type="entry name" value="LD45836P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="91"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="215" mass="24206" checksum="CF71E287C4C1EA40" modified="2017-10-25" version="1">MFKSSQEPDIPAALGPLNNFSTDELKDLLNNDDKFEEIIKDNQQLLELESEKEEIMVRNRSLAEFNLSKEPELEESKNLIQSLSEEGNQLCASVQAKLEQITNKAGTMTVDTALDLLQAAAAEIEEESEKVAEKFLSGDLEVDEFLEQFLTRRKIMHMRKVKVDKMRELMRRPSVHSSTNPGYPIAGNFPGMPSVPYPTGPLSMPMPVPPILKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F251</accession>
    <name>A0A232F251_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01001235">
        <property type="protein sequence ID" value="OXU24662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F251"/>
    <dbReference type="STRING" id="543379.A0A232F251"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF42">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="10">
        <location>
            <begin position="95"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="9">
        <location>
            <begin position="245"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="641" mass="71557" checksum="8BD5FE65537BDA05" modified="2017-10-25" version="1">MEIFFCSSSRLTDNTLKMKPLLCILALLLIGFGDARKQSFIRTYECLQGNRCQRTSRPVAPAAMRGHDNARTNIGLSQHTSLQACRLVCSNAAGLWPIPTGPMTTGTNYLVVSPRSFQFLNVNDLSESARTFVSDAIDVFLRNIQASCGHNCKPVERKVVVHLKVESSSLQLDWETNEAYDLEISSSGSEVAVLIAAQTVYGARHGLETLSQLTASTPSFNNYTASSGNQLVILDSANIRDKPVFKHRGLLIDTGRNFLPVSDIMRTIDALASVKMNVLHWHATDSQSFPIEIRSMPLMAMYGAYGPDKIYSVESMQSIVKYAKSRGIRVLLELDSPSHAGAGWEWGETQGLGNLAVCVNQQPWRDFCIQPPCGQLNPVNPNTFAVLRSLYKDLLNIFGRTGVIHLGGDELFINCWNATEEVTAGMSKIGLGRTTEDFLKIWSNVHHKQLDMINEESGDKATDKAIVWSSLLTSPEFIENYLNKTKFVVQTWVEADKDLNKKLLDLGYKLIISTKDAWYLDHGFWGVTKYHTWRDAYKNQIPQHIDNYNIVSYNDSLCLQDGVLGGEACMWGEYVSVGSLDSRVWPRTAAVAERLWSDPSKIGTAEAEPRLQAHIARLNQRRISPEAITPEWCNQHEGQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F264</accession>
    <name>A0A232F264_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001260">
        <property type="protein sequence ID" value="OXU24583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F264"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="62" mass="6921" checksum="DAD6D902D5E052E3" modified="2017-10-25" version="1">MLVTGDNFALMMAIQKGNAEIVKILTEVCPKNSEGKTPFALMEQQGDEDRIKLMLRHIMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2Z4</accession>
    <name>A0A232F2Z4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' exoribonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_012486</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001122">
        <property type="protein sequence ID" value="OXU25055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2Z4"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000001">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000004">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="17">
        <location>
            <begin position="639"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="18">
        <location>
            <begin position="837"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="16">
        <location>
            <begin position="1092"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1183"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1287"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1330"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1375"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1577"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1202"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1228"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1298"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1375"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1594"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1634"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1675"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1686"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1716"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1741"/>
            <end position="1750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU25055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1766" mass="201898" checksum="8C8A4DF9F4832A98" modified="2017-10-25" version="1">MGVPKFFRYISERYPCLSEKLKEYQIPEFDNLYLDMNGIIHNCSHPNDADATFRITEEAIFKNIFHYIEILFRIIQPQKLFFMAVDGVAPRAKINQQRGRRFRAAKEAEVIEAKARAKGQEIPKEARFDSNCITPGTVFMSKLNEQLKYFITYKISTDKLWQKCKIILSGSEVPGEGEHKIMDYIRYMKAQPDYEGNTRHCLYGLDADLIMLGLCSHEPHFSLLREEVKFGKTQKKILTPEETNFCLLHLSLMREYLEHEFSPVKDKLTFKFDIEKIIDDWVLMGFLVGNDFIPHLPNLHIENGALPLLYNAYMDVLPTLDGYINEAGTLNLERFEKFMEKLGKYDLQQFDEIYADLKYFEAKTGRRLNESQRNSKNSPDENATPKRTNKALNALIMATENELGEDSDEDLEDESDSDSEMHLEFVQHKRDYYMNKMEYANVDAETMRSQAEGYIRAIQWNLHYYYNGCCSWSWYYPHHYAPFISDIKNFKDLKLEFDLGEPFKPFEQLLAVLPAASKCLLPTAYHGLMTEEKSPIIKYYPLDFKTDLNGKKQEWEAVVLIPLIDEKSLLKAMKPCNAKLTPEERKRNSHGPMSIFTYIEKEQGIYEAPEYFPSIRSYAQMMLVNRDDILVPLERLVKGLCKGVQLSVYYPGFPTLQHIPHTACLAKAKVKVFEQPSRRENMILTVLPKELPPIEDLARKWLGKTVFIAWPHLVEALVLEVANSKTKISIAYPQSKHATDGNHNFNTESMNDMLLSTFNVQRKSITENYKTRLGIDVGNIEILIHAAPIMGRQYVYSAQGKMTLEKQWSDFPQAYAYQVVLKDISIHNHDFIQFTSITDVFKPKSVCFMLGHPHYGAMGEVTDGGVDLKSSRVKVAMRVTPEPNFDRVRQLQADTRMRYMPGNIAAQRLGISSHLLSRITGTVFVINGEGVDPAHASKYNLGLNLKFNKKNEEVPGYTKKDVNGTWLYSVKAVDFVKSYIQKFPELFERMEMNLVSSDMFLRDHLFPNTGAEGVDATVSWLKEQQKARGTTTRTCGTEELETEVVQAIEKEVDANLEAQRQAGKSVLMQVKPHLLYKPGLNSGSVPPDPKAQHRFFDRIVCVRDSFTVPLGYKGTIIGVQKNDNPLLTMYEVLFDIAFAGGLVMHGCSSNRSYRLAATDFINISYGLQIENKNSKVNIATPNWRQQQSQQNASPRGPDSWRQSQPQQHQSPHTADPTILNSFYPAFTKNGQSNNKQQQGSPQQKQQGQGRHQSANKAGFNDSPSPGRKQNLDQQSQFPQPSILLQRSQEPGKKPLPPIQNIQPQQHQHPKGQGPSEFQALWNELHKIQKPMDSPKRQAPASSPAKEKPSPTKSAVTESPQDPSAFLKAMLKISDENTQSQIPSSSTAASPANKPLAFPQMPKTTETPALVQQLFDPDFDFTDQSNINDEINFEIRLQHARQSEMKSGKSIWYCAQLLSYFQLLGTGFPRYAYHKNKDNLVCAQVTLPDMRVFCGEFCRTESEAAENTAKKVYEELKLSKMPPAASNARPNPLRAPSQQWFDNRMNNVRPSMPPQPNVKPMLPAAFPQVPMMQLPMPKWNPMVQQNPGFANMMHPGQPHPIQQQQLQQPPQYNRPKQQQQHQQGRFSQPQLFDNADSRSNRQDQQKKLTPFVPLQAQKKTRNVVNKQPSNEDNKQQKQQQQQSQQQQHDKKEKKEVYENKVDQKPKENSAEDVKQENVCSNNKTSESTVQSNQGQNAQKGQRSVKQRRSRVAAKFQSDPMANGGDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3W4</accession>
    <name>A0A232F3W4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_009546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001103">
        <property type="protein sequence ID" value="OXU25133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3W4"/>
    <dbReference type="STRING" id="543379.A0A232F3W4"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000300">
        <property type="entry name" value="Blast:Protein disulfide-isomerase TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012285623" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="429" mass="49926" checksum="8D282B51D80ECBCD" modified="2017-10-25" version="1">MVSLTRILLFATYCVIVNSTAASRVLELSDRFLDIHKEGQWLVMMYAPWCAHCKRLEPIWAHVAQYLHSSSIRVGRIDCTRFTSVAHSFKIKGFPTILFIKGDQQFVYNGDRTRDEIVKFATRLSGPPVQEVTRTTSFNTLKKDRDLYFLHVGEKSGTLWDTYNNIATVFQPHAFFYHSHPVVVEKHAPIEKTPALFVYKENLHYNFTDHHTITDKDKLNETLYKWINAERFPTFPKVTRGNIHQLYLTNKNLVLAVVEENQLEEVPPDMLEFKEMVESVIKKKRQKYHDHFQFGWITNHDLVNSIAMMVVPLPSLIVINSTTNHHYIPDDEPEKLTPHVIELFLENIQNESAPKYGGNSWIVRIYRSWFEVRSALASMWKGNPVLTIVLFGLPAIFLLMICYHIWCPDIFDADEEEEETKGSSHIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F411</accession>
    <name>A0A232F411_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001012">
        <property type="protein sequence ID" value="OXU25491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F411"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="45" mass="5086" checksum="83652BCC5AA317C0" modified="2017-10-25" version="1">MLIGLPQSFSSKFHNCVNRYRDFKNSGADTRSAFLRSDLLTGGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F473</accession>
    <name>A0A232F473_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001018">
        <property type="protein sequence ID" value="OXU25475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F473"/>
    <dbReference type="STRING" id="543379.A0A232F473"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000032">
        <property type="entry name" value="Nucleolar MIF4G domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="256"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU25475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="869" mass="99600" checksum="B507DC8C6319B684" modified="2017-10-25" version="1">MNKSLLLLLREKYAEQGAKMILDNKLMGALHCITAAIDYNQSDYRHYLNRCYCFLRMKQPVFALADAQYVIRLCTNIGHLFIANLRAGQAAYALQDYKQAEYFLKEATRMNPENCHAQRELLRVKISHIISLGFNEKDALMALQKYPSVLEAIGYLNESQKNSSISKFNNIFDIHDYNCDDMVFSSGDEEESENFETFNRMLNYQPGKVKILHLVAKPVKSQFLGGFSNCDKDNKLHINPDTKRKFIPTNKSANDKAIWVGRLTNDITEQMLKKKFKHFGNVISVYRPCNEAYAFINFEKSEDVTNTLINTSAHEIAGIKLAVRSALRQNIDLLDICDGETRKIAAESERRLVLQSDDESDVFDSDSNRGSKTKPAKKKKVRSSKQNEAELKVKKRKQSFSESDSELDHDDFDDNSDSDIEKKTKISKSYEFDSELESDEPAEIMKPVKKSKNVKQKTDSKNNKSAVKSKKDKKVADESFDVEENFGSDNDDELFNFSEEESNVDSDIKSDEQEGSEKEEEVWEDIYGRKRNKDGSVVDENKQKYVPPSLRSKQMENNPEKSEKLIALKRQVKGLLNRLAESNMHAIVSQLDELYMSNSRNDMNETITNLMLESIIAPVLTAERLVTEHMMCIAILHANIGTQVGANFIMVLVKKFHEMIQQPQNVENKELDNLVLMISHLYNFKVFGSQLMYQILDKMTEKFTEKEIEIILLVLKTAGFRMRKDDPLALKALILNLQQKAAAVKSSNSRIQFMLEVLLAIKNNNMNKIPQYDQSYVEHLKKIIKTLIRKGNTVSQLNLSLEDLLNADERGKWWIIGSAWSGKALPNDKSKKSTDNKPVYSQKILALARAQRMNTDLKTIWMHSKNCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4X9</accession>
    <name>A0A232F4X9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001001">
        <property type="protein sequence ID" value="OXU25538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4X9"/>
    <dbReference type="STRING" id="543379.A0A232F4X9"/>
    <dbReference type="OrthoDB" id="7692606at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="549" mass="63031" checksum="94DBEC8CDAB35AD0" modified="2017-10-25" version="1">MADEGDGQDHQLDAEFEEEVDEQEDLERGLGAQERNPEGGARGLQERNPEGGAQGGQDKQPGVGAGRQEELVRGAPGAGRQEELVRGAPGAEERNPDGDGQGVQVQITTGLKEYLQKRTNGKIILKEYKKSSDKGLPLRNNVMSLLVREVIGRERNYLLKDVNADQCLDRFVITRERFEILANEICSICTHEHPSVYFTASVKQGEQILVASGKLWNHYNYSKSVLRKANLLKNLKRNGPVNLADAEELEQINESDDINWLSNHLEPWEEVQRKWTNRYAERRSLLLEANMSVYEYIDKFACLKVQRAYELFHIDFKLLYPDKQQITAEQWAKIKPVLIANLASCGVKALDESVLINILKTGELSAEKEDFIILYLLCHLIKPKRNNKRTKEAAENGDPPRKLTFQERRETFILRAEVSNDIRPRLLERYMRGRETFQPVIIAVGEVLRISHYYVVVNDKLFEEKTALKALDLAFRVFFRIVNDKLFEVKTALKAWDLAFRVFFSLDCKYPKNSETIWVFLQQILYNINLQFDNTTLEVKGLIAYIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F560</accession>
    <name>A0A232F560_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000953">
        <property type="protein sequence ID" value="OXU25752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F560"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6982" checksum="15145A53A6883509" modified="2017-10-25" version="1">MKYYDKEIFPLALKEMQLSDTNSKAEQMRCGKGVFEDRRRSNAKSQKEISDDRLPRNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5C1</accession>
    <name>A0A232F5C1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000967">
        <property type="protein sequence ID" value="OXU25680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5C1"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="407" mass="46207" checksum="4A50EF9D1C450D2E" modified="2017-10-25" version="1">MENSSSISKKARLAAALLNNKASANNKIVIDELNGEYVLQDLMNNVCQYLNMYDLCHVAQVCKSWNIEVDRELERRLHHHFMVLPYLHSKELSDPSFHVSKILNNKPKVTILFPGTNHDVDDIQLEYDTYQTYRKQFPNNLIVVGAFEATMNTDVIHSCPLLIGSKIMDGYSPAGTLSLSLPMHEELSIKQSCIFESAYLLKGKDIINDMILELQPTNSNTKSTLIILAANHDESLDENEMTTLEKLIKSSFRPNSYTLWGFATSDRLFASSPHEKRNKNVTENETRMVGLNLSGPNFKSWSTVISTHSTKNEFIERLTNFKYRIQLKKNSIGLVTAPVIDHDDDDNDDDNNGGFMEDIKKIFPEIPFLGAFGKEDDYYFGIDPMSNNESKDIIGIDIISILICTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F632</accession>
    <name>A0A232F632_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000917">
        <property type="protein sequence ID" value="OXU25933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F632"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10199" checksum="75407CCE85ABA036" modified="2017-10-25" version="1">MERGTRKNRPGLFAHCLLGIIRSPSSMAKLLLLLEKIPSRYLPGMELKNYFERKLLSSIPIPRRVNSYRRRGVSNDFNANSIDTPPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F730</accession>
    <name>A0A232F730_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Twinkle protein, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_010849</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="NNAY01000754">
        <property type="protein sequence ID" value="OXU26664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F730"/>
    <dbReference type="STRING" id="543379.A0A232F730"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01122">
        <property type="entry name" value="Twinkle_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000845">
        <property type="entry name" value="Mitochondrial helicase twinkle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SF4 helicase" evidence="17">
        <location>
            <begin position="355"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU26664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="623" mass="71276" checksum="E6F78A4913F3196B" modified="2017-10-25" version="1">MLLKRFLPLEGLLSKKVYKNQRARFYHNLAEDMSTVTTLEIKRLLKSASVNVLEGHACLVTNYPLCEDAKKQNCKLYINKMTGFFMCGNCNRVGPWTTLERIVEPKKTKKKTEEIIFLRKGIDILPDYSKQWNELRLSSELIENLSPDAYKNVVEKFNLQHIPQEIMSQMNLLYNESTQSLYFPLLTFRGLIVGYKSLSADSSLTKTVPATNTSGVIMYKQKNLKSDGTAVLVPNVEDLLAVASKKAANLIICLPYGLQHIPQQILPNLESYKKLILWFGNDEPSWDSARHFAKKLDEKRCHFVRPTDYQPQPKIAAHLGYDLKEIIQNATPIWHKSITTFQSLRQDVLSDLQNIDKVQGVKWSRYPTLNKILKGHRRGEFTVLTGPTGCGKTTLMSEYSLDLALQGVNTLWGSFEIRNARLAKTMLQQMAGVPLEDNLNKFESYADEFQKLPIYFMTFHGQQNITDVMEAVEHATYVHDIAHVIIDNVQFMMGMSDESKFVDRFWKQDKIIGSFRTFATKFNCHVTLVIHPRKEREDGELTTASIFGGAKASQEADNVLIIQDKRLSSIRGKKYLQIAKNRYCGDLGMMVLEFDKSSLSYAEKKKRKPDNTDDHEVTFVGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8A8</accession>
    <name>A0A232F8A8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_014471</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000671">
        <property type="protein sequence ID" value="OXU27074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8A8"/>
    <dbReference type="STRING" id="543379.A0A232F8A8"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20817">
        <property type="entry name" value="C1_Stac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000022">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="416"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="514"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU27074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="619" mass="67687" checksum="EA96A5D4482C783C" modified="2017-10-25" version="1">MECHGQNVIRLVDDFRGRTSDSRGDTNGMRRVWDSLLRQVEADAAAHLELASVLQQQLSRPALEGCFHRKVQHRKVFTHREAYEQVVAKTEEKLQRARAEYKRAYGALLAAPETSQDSELKRAYLEAHNAYVLQLRATNAISERYQFHCLPGLLGEVAEVYEELCGLTCTCVSGISEAAGDRVAEQIKRYQALAKEVKVVNPQSDLQVLARSLSSVAQPRKPPRRLFVPPSPPEQTSSERINSVPALRDELVPTGSGTLGMMEEDLKLEADRLAQEIAHLQDALDTLNRMQRKSAEGNLYTKVAELQEDISMKRFDLGVAQLQLAAVHAQKELFGGGAEAAQPDGTGNRKMSNGSTGSNTKHKWLKAFKSLKTTPTTPPPNEKGKQAMYHAVSSVVAMSRVLSMFRRKNLESESGGHQWREYTYRKITPCDACGQVLRGHARQGFRCRNCKANAHADCMSSVQPANCPSLLPKRTAGIPLLRRQKSTAPPVDETPSSEQNVDAIYQVLKQAGEIRGNSTNSPPTPPTADHPPSGAAPSSSARTTTSSQPCSSSTSGGSVSRARPFGQPLFLGQSTESSDYDLSPNCPQSAVSPTSGQQQRSPGSSTTRSIVKRISGAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8J7</accession>
    <name>A0A232F8J7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Splicing factor 3B subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_016205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000655">
        <property type="protein sequence ID" value="OXU27161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8J7"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000002">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000027">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000031">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="9">
        <location>
            <begin position="143"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="10">
        <location>
            <begin position="574"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1345" mass="149633" checksum="968F38FB48CFEA34" modified="2017-10-25" version="1">MSVQQGEIVVESEEEPASSCILSVGKSKKSALYSPTSVFPYPAQTVQIPAGPDCTIHSIPFRPVLRPPFLHLRSLNKRSECEWPTTTPKSSAIIRKHRLGSSRCPRKISETPDIPARLNKPRSKKARNLTVIIQSSQDRATGITHAVHGNFSGTKMQEILVSRGKSLELLRPDPNTGKVHTMLTVEVFGIVRSLMAFRLTGGTKDYIVVGSDSGRIVILEYVPAKNVFEKVHQETFGKSGCRRIVPGQYLAIDPKGRAVMIGAIEKQKLVYILNRDPEARLTISSPLEAHKSNTLVYHMVGVDVGFENPMFACLEIDYEEADTDPTGEAAIKTQQTLTFYELDLGLNHVVRKYSEPLEEHANFLVSVPGGNDGPSGVLICSENYLTYKNLGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDVVTEIKLKYFDTVPVANSMCVLKTGFLFVASEFGNHYLYQIAHLGDDDDEPEFSSAMPLEEGDTFFFAPRPLRNLVLVDEMDSLSPIMACQVADLANEDTPQLYIACGRGPRSTLRVLRHGLEVSEMAVSELPGNPNAVWTVKRRIDEEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSALGEDALVQVYPDGIRHIRADKRVNEWKAPGKKTIIKCAVNQRQVVIALTGGELVYFEMDPTGQLNEYTERKKMPSEVMCMALGNVAAGEQRSWFLAVGLQDNTVRIISLDPSDCLAPRSMQALPAAAESLCIVEMGIKDDTSEDSNQMQSTLHLNIGLQNGVLLRTVLDPISGDLSDTRTRYLGSRPVKLFRIRMQGNQAVLAMSSRSWLSYYYQNRFHLTPLSYESLEFASGFSSEQCPEGIVAISTNTLRILALEKLGAVFNQVSFPFEYTPRKFVIHNESAHVLLIETEHNAYTEETKQQRRLQMAEEMQEAAGSDEAAVARELAEAFLSEEPNEQVFGAPRAGPGLWASLIRVMAPTTGTTFQVHRLEQNLAALCLALVKFANQGDQQFLIVGVAKEYQLNPRISNGGFLYTYKVSSDCTSIELMHRTTLDEIPLAICPYQGRVLVGVGKMLRLYDMGKKKLLRKCENKHIPNAVICINAIGQRIYVSDVQESVYAVRYKRQENQLIVFADDTHPRWITTTCVLDYDTVATADKFGNIAVIRLANSINDDVDEDPTGNKALWDRGLLNGASQKADTVACFHVGETVMSLQKATLIPGGSESLVYTTLSGTVGVLVPFTSHEDHDFFQHLEMHMRAEHPPLCGRDHLSFRSYYYPVKNVIDGDLCEQFNSIEPGKQKSISGDLERTPSEVSKKLEDIRTRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F980</accession>
    <name>A0A232F980_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_003759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000606">
        <property type="protein sequence ID" value="OXU27414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F980"/>
    <dbReference type="STRING" id="543379.A0A232F980"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00244">
        <property type="entry name" value="NEUROKININR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU27414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="315" mass="36670" checksum="83D0EF8C0552D1B4" modified="2017-10-25" version="1">MSVRFVRRYVAIVNPLKPRMGKRTTLCIALAIWAVGAVLSLPMLLFYTTFTHNFPNGEVRVICYPSWPDQDNSGQSYNEYLYNVIFMILTYFLPIGAMTFTYARIGVELWGSQSIGEATQRQLDNIRNKRRVVKMMMVVVMIFAVCWLPFHVYFIVTSYLPHLTNEPYIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRRGFAQFFSWCPLVRVGHEPALSRSEAVTSRYSCAGSPEIRTRISRNGTMRLPLHHQCTTAETTTTLATSRRDSFTDPHHENGNSRRLHGHHNFYHNQRLPYTARFQKLESQPDCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9W8</accession>
    <name>A0A232F9W8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_014521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01000561">
        <property type="protein sequence ID" value="OXU27651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F9W8"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU27651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1815" mass="205420" checksum="A02330C10DF282A7" modified="2017-10-25" version="1">MSNESDDTEGHGINDVELSLTMPIIQNTCPPCVSIWMEKMRQGVLSNTHFKEHWRVWVPKIYKLEPTDNCLEWVFNEKEAQTILYDPLEEFICNGNPHEILKQLSQNDRPPSICGRVFKAGEPTYSCRECGMDSTCVLCVDCFKQSAHKNHKYKMGISIGGGCCDCGDTEAWKKEPFCKIHLAGIESKDAPSNKLPDDMAQRAAATFRAVLKYCYDLLSMEHSPSLPNDLCIKNDEDSVSLLASNDTYCTVLFNDETHTFDQVIITLTRVIKCSQRDAIEYVTNIDREGRAVVKCSGFQHCNELKSEIEKFTSRHNSRPLKVLVEHAHVVAHQIFAMKLLGWLQQFISHCEGFRLIFSDVALNDKMPDIPIVKGILIRDYQLWKAARTCWHRLFISGMLTEYESKKALAIDFTNNYGTVLKDFIRDDHDHSYSIASLAVQLFTVPTLAHHLIAHHDALLILFNTFISESSRRCNAAGKLEFERNAPNNAFKRAQYILYDLRYLLSAKPETWTDELRRGFLQGVSLLLQLLGSMQWMDAVVRQVGQHMEYEQEWESAFNLYIKLSPVISLALEWCGSDRIVLIKAFRLVLKKLEEQPGKAPTNFREVADHSASCIHYDVSTEPVSIHLPLSRFLAGLFLHLEKYDLTFQGTEFQTLSKPTPEEIIEPVLRAQAMISQVHAGMWRRNGYSLIHQLYFYHNVKCRTEMLDKDIVLLQAGAALIESNEFLIHILNKFNLINWAQPDFETALLKTCEEDSIRQTINLVEEFLALLITIIGERYVPGVGRVTQDDCLKREIIQQLCIKPLSHSELNKTLPDDVHHETGMERVIHEVADFKKPQVVSAGKGVYELKFNFYSEYNVFFYHYTKEELSKSEEAQRKRRKTVGELECCPPPKLPRLTEMLSLVTNLLQCDVMLSIMNIVLTRTLDLKARSFSEPQVHKILHLIGYALQEQESGYYPFLAFTERAIKWDIYKLLETMQNSPRIEAHKDLLTWVLEKYRQVAGSPIPEAPEPPAPQPTDPGEDTEKLEKGSQEWRMKMAALKRAQVMAQMEAMQKHFMKKNAKMFQEAALDVSNKGSNDRGSAMDLSESLDETSVALGRRQTNRLCFEKSYTCILCQEDQCIKADESAMVLAAFVQQSTVLCQLPHERQKAQQPPQSRSVAEKTPLFLSSYLGASPHTSTCGHVMHSSCWQKHFDNVLAKENRRPYRLRQPASFDVEKHEYLCPLCECLSNTVLPVLPSLGTLQPTPADQPDLSFDRWLDIMSALTKCKRSNDNKDTPKVARNEDCRYCKFLSQQELDAAEAESGGNAQATPSTSSLISCPIEAIKAQGPDGEALLSLYSQPGPRLSKNLVEMIQLFTQTTYTKGLGCEPHDDDSRVPLLAWKSTAYTVHAIEFLLRDTEKPLLGALSSRQRDSLEGLARISAVISATWPSNVAGSTSPTSSENIAEYALECLTCFLNNAESNYSILSWDPFGMLVTLLASLSNLLSSRTDDPHSIITGNVAEAHATRLVFTALVVKVLLMSNFDQDEKMDVDDDVADDNNEAEMRDASKPSAILNVMKALNISTGNKSDAEIWLKVQECCEPFLRCCVLYFHYVTDVPAPVDLTVLGGDSFEAMCNYLGLPETFEELFNTEKVLQLAVQWSKHPEMVNKDTATREPLKINRLVDLPDDYSELMNTVSMFSCPNSDKEDSLNPTMCLVCGGMLCSQSYCCQVELNKIMVGACTYHAHECGAGVGVFLRVRDCEIVFLRSPNRGSYGCPPYFDEYGETDQGLHRGNPLKLCRDKYKRLNQMWLGHGLYECIARAIETATSATGQWQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA46</accession>
    <name>A0A232FA46_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">IFT80/172/WDR35 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000552">
        <property type="protein sequence ID" value="OXU27721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FA46"/>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="9">
        <location>
            <begin position="631"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1749" mass="193804" checksum="DBE5585BDD844A43" modified="2017-10-25" version="1">MLLKHLASVLPSHDSENRVVAIAWSPNNLKLAVASTDRSIYLFDDKGVRKDRFSTKPVDSKNGKKSYLVRGIAFSPESTKIAVGQTDNIVYVYKIGEEWGAKKVICNKFPQSSAVTCIAWPSEGPIVIGLADGKIRAAVAKANKAQTLYSADSMAIALAVNARGTGFLSSHADGSVIRFYVAEDGASEPVGRVLTHPVPVYALAWPQSHIVAGGCDKKLVFYDSRGKPTKSIDYARDSGNTEKDLSVACCSPSGQSVAVGSWDKVRIFDWSPRRNVWEENNSKSLTNFYTVTALAWRKDGSKLVVGSLCGAVEMFETILRRTLLRGSHEVSYVGPSQVVIRSLEGKSRPVVVKSNSGAEIEDVKVMGRSDNRVVARTPISLLICDIDQNLLSEIPWEDKNGSEKFFFDYPGVCLIFCAGELTIVEYGRNEILGAVRTEAINPHVVSVRINERRLPGQPDNKRLAYLLDPRTVRVVDLANGNVEVALVVHDARIDWLELSETGRRLLSRDKRGKLWLSDDQGGHTLLLNGTSFVSWVVGSDVVVAQSGSNLAVWYNVDAPDAATFIPIKGETMDIVREGGRTSVLVDDNGVEVAYLLDEGLIEFGTALHDNDFGRVVLFLEELGDRPQTEAMWENVANNAMNERALTVAARCYAALGDAACVRLLKEIVEIGERYAEDNLGSDPLDCPDCWAKMAILKGELRTAEAIYLVQNDLTKALEMYQRYWHWEDALNLAQERKWSGLAQLTDKHMAWLMDTGQKAKAASLIESNNPRKAIKLYLEAKRPGRAARLVLSQDELITDEKLVGDIVRALRAQELMELAGEIYERTGDFHAAIEAYGQSGVFVRALELARKTEPNSVVKLEKDWGHHLMSGAQYDAAINHFIEAGETSLALNAAVLAHQWKKALQIIQVIDVDDDPEIRGHCERMAEHFASTNDLGLAERLYLRAGLARRAVEAYAAANNWQRVQELAQTELDPAEANELLAGYANDLRAKNDYRHAEALLAATEQYDEAIAMYKQAGMRQDMVRLVAKFRPELLKETHAHLAKELVKAGKPKEAEEHFLGGNNWRGAVDAYRSANMWEDALRVAKQSSGDKAAQQVALMWSRTLAPELGARVLARLDYLDGCLQLACEANYFDWALEIVKYGSVEQQRDVHYRYAMALEDEGRFSDAEREFLKADKAMEAVQMYIHTREWDAAEYVAQNHCQEGLSQVLVARASEAAEAQDYATAESLLLRAHKPEIIINHYKNAGMWSEAMRVCREYLPSQEAALRRELGQRTSSVDNGGSSQVILEEARHWLEVGEVRAALEVLLRDPRAPQTALLQAAEILLQRAEPELAAELGGDLGSRLFSCGEHALAAQVFLQADRIKDAVSALAAVGDWAKARRVVRELAPDLEIYLEDLYREAMIKEGQVENLARVDANAALDMLMRKGQWNQVFETAKTQGATVLHKYVAIRAAQLLKSDSVIDAVQLYSQHGAPPISQNFNLYYHLGESVLNSNETCNEYVYLAKLRNVMLNLVRSLDTSVSSVASKFDRVLRCAHYSAVRCASRQLGGSDLSGIVLKSSVGLLRYTDILLADRAYYEAGSEARKAGLSSEAFVFLNHFLDLEECIEEGDGSVLDVDDLRVTDFPLEVPLPPSLSLSRENREEVREWVLTVSMDQRVEQGLPVDQRGVYVGSLTSHATDLVKPLVECALTGYPIRGASVQFEAGRKLAAREDWNKFVAAARQTPGDSALNDVLSFVQDWCGTAPNYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD17</accession>
    <name>A0A232FD17_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Intraflagellar transport protein 43 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFT43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000440">
        <property type="protein sequence ID" value="OXU28383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD17"/>
    <dbReference type="STRING" id="543379.A0A232FD17"/>
    <dbReference type="OrthoDB" id="206950at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029302">
        <property type="entry name" value="IFT43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15305">
        <property type="entry name" value="IFT43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25010" checksum="62340E90E09EF620" modified="2017-10-25" version="1">MVDSWASDLDVTSKKRVKTFRKCISASTITTMSSKDKSSIFRLIPRLGRRAGHGSIQEEKNDDDLLDSPESLSSGKSSTKGPAPVAPPRARKTGWGDDLKSAKQRGVSAAIDQDRFSNNNRNSKEDDIPVIPDLDEIIEDTGALDISYAPSVGLNRAAAAYKELDTDLVKNQLLLTLDDVDLSLLTEKLYPEHLVKEPDEVWSWESLFTQVASEINSESQTKADEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDJ9</accession>
    <name>A0A232FDJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000369">
        <property type="protein sequence ID" value="OXU28841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDJ9"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24455" checksum="85DACF80A5AF5542" modified="2017-10-25" version="1">MLSLKQDGSGSADLLEKQSKDTYLTERPIFLIYFGICVTICVTASWVGATHCIKFLYFQKDHAVANLTISLNLSHPDNRNKQRIISYNAPFFTTWFCTNWTILYFPVYFTIQAIKSKCITPSSVINESLRGFRDKGLTGGRFLTRCSLFCGLWVSTNYMYIHSLRILLATDVMTLFATNVACVYLLSWVILHEQFVGVRYTLHLIAAIVKDKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEK0</accession>
    <name>A0A232FEK0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000328">
        <property type="protein sequence ID" value="OXU29191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEK0"/>
    <dbReference type="STRING" id="543379.A0A232FEK0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="52004" checksum="2439636E41241A65" modified="2017-10-25" version="1">MYTVNPYNDRMTNRWSEVNKFVQHNDHPITVYKYEFPSKSFSSFICDDLLMDKTLNLSGYPITIAKINTIFDQKHELLVTVASRIISEIWHFLKANISIKLASGSFEVDELGNPQGKALLDLLYGKYDMKYTFDFERRYFWHYELNTYIPGGICYVAKKSESFVSYENLTSVLSHSLFVQVFLAAIIVSVLVSRWLRLNFGQVMLNTVRAIIGVAILHSPKSIIPRIAFMHVVIYSMVLNSYLQSHLSLSMVGEPKSLKIEKPTDLIKYDYKIFAKNVTHQYFSYWPFIYDQIQETKSLYECVKAIKVDERICCADDCHKIRSRIDSNGRRYYQVSEDIYLQWYYVFTFERDHPLLPRLRQVYARLYQSGVIVHLTSPLDPKTINPKTENSLTSLSTISFSEIEKGFYFIAIGQIAGMLVFISEVLVNLVLIRKSLKILVRGIKRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEX4</accession>
    <name>A0A232FEX4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000364">
        <property type="protein sequence ID" value="OXU28867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEX4"/>
    <dbReference type="STRING" id="543379.A0A232FEX4"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="258"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="704" mass="81354" checksum="6863630D51982F18" modified="2017-10-25" version="1">MEQQENAEPVKIGRLKISDKPTTESHREYLDMDTDEEEFGHQETPEPQDEAPPEPDKPVFTGAELDTLVKYTKELTVLPNLQDDSWSEQVEETIREYFRDPTKTIITVFFSETQELQALLDFPEQTHGGLTYFLRKPWQVYRADDFLSSVTFGSVGDRIELTAIKFVGGVYAPMAFKSGDWPETFLNPLASTTVTRDEIFSNINDFLTRAIDVTYKPMGILVLYVPWEGCAEQEKQHPDMERESVTRIQRQKERALLINRLEKVARTWIKQIREALMISSFNSQELHDIAGEFDFWQSRYENLACISRQLQHDRLLQIIKQLKKVKSSSIKDLKLLVSRVKSALEETKSNLGCLYLVLQSCKSLDNSNQIQEFLPRILHAIRFAWTTSPYYNKPENIERLLCSLSIHVVKICKSSINLKLIFDDPKKCRECLASTISCCEAYSKIYDSITENCKLNGTNWSVDKAVIFNSIGAFELRCRDVSEICDTIIIYGGLNKISIGGTRGNQHEMEYRRVMDYFLQMTNEMRLCCEYALDITRIKWFQDISNFRCDVAELESTVKNLLNSLFEDVKNVEMGVETLYTLLKFKERQGFQDILHEKWAHVWELFYDEMKICSLPPTNVEMVADKVKFSQSEDALVSQIHKSYLTRLHKILVNASDWLGDCDVQFEVPAKQMTGSKIDDISISGLGTLRLYVFKVGNNVERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFP8</accession>
    <name>A0A232FFP8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Galactokinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000296">
        <property type="protein sequence ID" value="OXU29383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFP8"/>
    <dbReference type="STRING" id="543379.A0A232FFP8"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="4">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="5">
        <location>
            <begin position="384"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU29383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54079" checksum="01198B1814B7DF60" modified="2017-10-25" version="1">MALLWKTRSEMSAAQNGSLIGGETISILKPDERLKGRLDALASHFRSRFQREPSFLVRVPGRVNLIGEHVDYCGYSVCPMAIEQDVLVAVCRSDDDDALRLTNVDSKYQDYLHNDLQEIRKFRLDNHTLGPAWYKYFLCGVKGALEVIPEKRRPRGVLAAVCGNIPPNAGLSSSSALVSAALLATVHASQHEMSKEDMATVSASAERYIGTQGGGMDQAIAFLGKAGSAKLIEFNPLRGFDVKLPDDAVFVIAHSLADHNKAATNDFNTRVLECRLAAQVIARRSGLEWRSVQKLIDAHQLLGASLEEMAAIVSRELHEPPYEHQEICQILDTTPEELNRISKVPVDTKQKFKLRQRALHVFEEAARVLSFRSVCERKDLDAADRLRQLGNLMSSSHSSLQSLYECSHPRIDVLVEAANACGALGARLTGAGWGGCVVAMTTNDRVEDFVENLKKKFYHNDECAKGLDLMRYVFPTEPKNGASIHYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFW0</accession>
    <name>A0A232FFW0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000289">
        <property type="protein sequence ID" value="OXU29443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFW0"/>
    <dbReference type="STRING" id="543379.A0A232FFW0"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="807" mass="91089" checksum="2D3BE8F1DA2098A5" modified="2017-10-25" version="1">MRRSTQLTIGDKQNGGKRSILNNAAYSIFQSSESSSSRNALSGSNGNRRVNGSSSFLQRSVSADNVVVRQRGFKPSDRHDPAKRNFLESLTSKILHFDMESGHSTPIDLQKLLTPASDSNELLHVKNKKMYASSYFYAPTHPTVEDQVELARRISNSLSDVKNVKSKGQSMYVNRKKRSVKWIHDGAEDEEEPSSPVHKDKVPLKCMMNPSGKVLDIHGIQALGEEPNIPSTPPHPERLFDIVRDLNAQKGRVRDARVNLSAGAEIFAKRRKRSEKWVVDTEQPQSPSSFGYGKAPIYPTKQELGVNENTKFDNKPYYNPFTVDISMDYSTPPVTSCGHLQHQHQCSRASFSSAHSDCGVIPPCHTEIKKIYLREVAVGTDEAANNKMEKSRRMSFDGSSARGQRSCNSSVSNGYSRGSRGSKNGGYNQHPGYQGYQPRSNGYNGHHHHHHHHHQHNGHSHHHHNGHNGYNGNAYHQQIAPANTLYPAYQNGNGYQNGNGYQNGNGYQNGNGYQNGNGYQQQPQPNACAEEADETPQEDYTPVPVKQLIQEFEKTCRPVMQYKQYCPKVAQQPVNNNGDISRYFESRREVIYHNNQQPQRNQYRSGNNNGYASSGDDEDDDEDDDEDDDGSLDDSLSPVDFYRIDDRRLISQTVSNGGNRSSSMSTLDEYYRRQLMQQHQQQLEDGKKFVDSEAEVPMEARAAALAAVVAQDELLKHKKHLRNTPVLENLVAGTTTPECFKKEFTEEFFLKTATKLYENTYHGPKISSYQNLTNYNTAPRGWDQSQPIYRPVKFEKPQDNKIVYSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG53</accession>
    <name>A0A232FG53_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 SUMO-protein ligase RanBP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_012326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000245">
        <property type="protein sequence ID" value="OXU29741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FG53"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13171">
        <property type="entry name" value="RanBD1_RanBP2_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13174">
        <property type="entry name" value="RanBD4_RanBP2_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000582">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000018">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000003">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="8">
        <location>
            <begin position="1234"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="9">
        <location>
            <begin position="1653"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="9">
        <location>
            <begin position="1710"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="9">
        <location>
            <begin position="1766"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="8">
        <location>
            <begin position="1929"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="8">
        <location>
            <begin position="2581"/>
            <end position="2718"/>
        </location>
    </feature>
    <feature type="domain" description="WH1" evidence="10">
        <location>
            <begin position="2596"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="788"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1066"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1199"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1457"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1866"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1902"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2543"/>
            <end position="2584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2730"/>
            <end position="2762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1210"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1359"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1375"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1409"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2545"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2563"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2731"/>
            <end position="2761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2878" mass="317708" checksum="6FF910B757BE9C37" modified="2017-10-25" version="1">MLRTKKEVDRHVQDIFRKLQDETERTLRCYKIAELYYNVGDYESARRYLSRYVEFRTEPKGHKLMGQILEALGQKEAAVVQYKRAFELEPRQEELILKVCELLADPEVGIDVNRAKYWVDRADKLFPPHKSVFQLKEKILSIERPTNNQEDLENLITAELATRPTDVHLRVKLIKHYMERSKLDEAYKHATDIEASSIHRDSVIWYQVLCELFLKCKYNHQTMWSFWISYISALERYAALSLKEQGSSVRKTSEAIQAVYNFDQHLFEAKGQSFSSYPSLTESIFVHMWGQLHFHLACLLIQNTQREQGSWSEAGRLCAPLLLTAMHVKPIDLTASWATHLEAPLKNQLQIWYREGSYRCSQAGHVLHDYARGNQKKLISNIEKFCSGSWRERVYQRIFVGKIYQKIRSSYFTNNNATTPPFRLVSHNELKRFDEVAEEVWPYSLHHQVWPAIKSRNSNSNSSSLHSSRYEGPQPNLTSHLFPDLQFSVYNLGQASPVTLSHLDVDAFLNAAALCATAVVEEQQRNTLWNSDRLPTLPADLTNPLCSDEQEKWWRAAYKMYRKEAIDDIGDTRQCLQRGLEVVRCIGNHGLHSSVLVHLARIFHYRAKQLKEKNRESSDIPALEARSEMYWSAAVPLLERLQNNQAIRSSHVKLFDYIGKDMNNMELTHAIEEGKILLAQKLVRDKLYEQAIEALRALKCPEASFEQGKIYKKMADETMSNLPKESVTSEMRSQHIIILSKARNCFYLTLDRLRSPDTDPKHPLNSELGTHITAVENELRRIDPDTLYADRNRNDCDDLSEESYSSAHSDEHPLVTNSLPVMNNSFQTPMRSIRRTPRQSSTPRHQNQDMLDVSRNRNEARPSPERLDAQIRQLVHSVESLTEQNQEQHRDIKMIISKLDELDIKINYANYSSTSLPTPAANRTSALVQNLFAAQRHPYSPLVYPPPAAAGALPGYCSSNGLPYDAATAAAVAAAGQHLPGFYSAVAAAYPIPSPYRGALDSISQMQENVLQHGIFGQRLGGQLPDYTANQHIAPPQQQQLPNQVRPSPNQLGHQMLQELRPAQVNDPAKNEPKLGYAPPSEPSVSEPPYSVQPKDASNVSSTTTSAGSRNALPANVVMTTSDTLPTTVPSIHPTFSVTIPAQHRLGVSPSSAANQQPHQQFQGNEQVPHSYQISMPSQPTIPTTVNLPPLSATLTISSPIIKPQDNQNSSLLSTGSRHSSSDVTEVEHDPIPDFAPIIPLPDEVPVTTGEENEEELYCARAKLFRFVDKEWKERGIGNVKLLKNTEGKIRLLMRREQVLKICANHMLRKDMELTMMKNNEKAYIWVANDFADEELRLEKLCIKFKTVEEAASFKENFEKAKDSLPDEEAKPATETKTASSGTDKSSNKPTKPDTVPSNKPVEKIGGFSFTSSPIIQKAPSTADTPEQKKPEEQAKPSPFASFSFVKSSEPAAAAAAAAATKTPTTGGFSFGSPATPGTQTPIFGQDLSKATLRRPLAAGPTDLSKGSEVSRIEDGEIVIAEQNINLMHYTSDNKLWKEKGIGIIKVLFEKSTGRVRLLMNTEDNSKTIYNQIVPPRTVFNLKSDTVNWTIENEKNKPDSYLARFKNYDQASLFQKSLMGYLEKSAKLASSNKSTSSSSSSQQKPLSEMFKPAAGSWECKGCYMRNSASAKSCVACQAPSPSTDAAVAAPAARPTIQTVSKNLFDQFKPAAGSWECKDCYTRNDAGVTKCVACQAAAPGQPATEIPAPAVTTSTTSKPLSELFKPAAGSWECKQCYVVNSQSNQYCAACDKAKDPSMPPKPKTTGGFLINSQAPDTKPTFSFGIPQAAQPAAAKPSAGFTFNFATKPASENAVSSPINIFANNKSPNSSFQFGMQPPSTPPSSGGGNFTFGSPGKSFDFQFQAKSPPVKSPERHETSDEDVVEEAEDVYFAPVIPLPDKIEVKTGEENEDVLYSHRAKLFKFDSATKEWKERGLGDIKLLRHVETKKLRLVMRRDQVLKLCLNHAVTPALEISSKDDKTWMWTAGDYSEGEIEYMQFACRFKTPEIAADFKNAVDNACSGVENTSTVSTSAVSSITTATKKDSSPDIEVVYEIKVTPEEKAAALKLKLPENFYSYKYKSDCPGCRGCKDSDESLFKNDKTKAHQPSVQAKPNAPIFVKANDSAPVSASASAFGNIFTKPATTTASITQPGSGLKMAFGTSTPPIFGGGKSTLGDDNTAKSTSFVFGLSSPIISSVKPDSQGSTGLENLKICEPTAKPQVSSTTTATTTANIFGGFGGSSTTAASTKPPSTSIFSPPAKNIFGESKPVFGESKPIFGDSKLAFGESKPLTMSSGIFGESKPPTANIFGGTAAPPAAVTTTTTSSTTNSIFGTTTTITSLFGGTASTLPSFGALANQGNTTANGGLFSSNTFGSTTPALDAKSTTVSAPASTTTTTTVGSTIFGGNAATQFTSKLTFGTGVAPTTNVFGNLSSGTSNIFGGSKPSIGDSESKKESAVNFLPTENSLSFSTLAQNVPAEQKPAFKTDPNFTFEGAGASVFGVKNAQKTGDKTKKTPNSKKDKAKDDDDEDGDDENENGDEHDPYFEPIIPLPDAIEVRTGEEDEEKVFCHRAKLYRYDNNTKEWKERGTGEMKLLHHAEHGTYRLLLRREQVHKVVCNLLLTSDLEFRELNSSDRAWMWAGMNYAEADSPEVEQLAVRFKTPELASQFKEAVDKAQQALAEKQMQDIQNAAYDSGEEDYPAGGEYDEDEEEENDEEEDEEDEDQVTMFEKRATVYAQNEGEVSWKHVAMGNLKVLYDSSFFGVKIVVENDNNELASETVISVDTTMQYNEKECTWAAIDYAVEPQVRRTLRAVFSSSQTAEQMYQTFQEGLECATKADIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGX2</accession>
    <name>A0A232FGX2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000211">
        <property type="protein sequence ID" value="OXU29994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGX2"/>
    <dbReference type="STRING" id="543379.A0A232FGX2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="164" mass="18681" checksum="194F0CE4C2E6D217" modified="2017-10-25" version="1">MCMEGGCRVCIVAVKIKDEVLAVNSCLVPVFLCNGYRNMIFKHSYYIPFFFNPHCLFTIFTSWDVITIEGIGGKLIDYNLLQKTLADMNGYLSAFGLEETNICRCTGCRPILDARLHILKDADFLRVFTIEQIHEIFKKYPKASYILHGGNTENGKIHDPNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH75</accession>
    <name>A0A232FH75_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000204">
        <property type="protein sequence ID" value="OXU30042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FH75"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14881">
        <property type="entry name" value="MYSc_Myo20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036029">
        <property type="entry name" value="MYSc_Myo20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF498">
        <property type="entry name" value="DACHS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="52"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="897"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112407" checksum="093E697F519C856A" modified="2017-10-25" version="1">MVSCVTALTTRSASSAVISDAKSSSKHQQQQGKTGSNGQQQQQIVGPVNSAALDDLIHLPGPLTEDAVLKCLQARFCAKHYHTNVGPILVCLNPYTNVGNPLTLTSTRAVPLTPHLNRVVQEAVRQQSETGYPQAIILSGTSGSGKTYASMLLLRQLFDVAGGGPETDAFKHLAAAFTVLRSLGSAKTATNSESSRIGHFIEVQVTDGALYRTKIHCYFLDQTRVIRPLPDEKNYHIFYQMLAGLSHDERVRLNLEGYNLKNLRYLQHGDTRQDEAEDSVRFQAWKGLGTETRDRTRPRTPSGFRPGRLAWYLMGSLIVGVLGIPFLDVVRVLAAVLILGNVGFTDGPGVEVGVIGENELASVAALLGVTPSALLRGLTSRTHNARGQLVKSVCDANMSNMTRDSLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQAEVTSQHASTIGSSAGGTGSRSMTALNNAVRHATDGFIGILDMFGFEDPKPSQLEHLCINLCAETMQHFYNTHIFKSSIESCRDEGIRCDVEVDYVDNVPCIDLISSLRTGLLSMLDVECSIRGTAESYVSKVKVQHKQNPRLFEPRTLDCRSFGIQHFAGRVTYDASDFLDTNKDVVPDDLVAVFYKHTCNFGFATHLFGSELKALYASDTVPRGVSXRPPTLTCELNGDEPISTLTQDFHTRLDNLLRTLVHARPHFVRCVRSNASETPMQFDRNVAMRQIRSLQVLETVNLMAGGYPHRMRFKAFNARYRLIAPFKQLRRSEEQAIEDTKLILQNAQQLKSSFNASTSWALGKRHIFLSEGIRQQLENLRSEIRRRAATGIQASWRGWRIRRRWTLRRSKLGSGLPSGSIGQKQSQHQSTSSVVAAAAAAAAAAAAGNGTLQRNVAATSAGSGTGVRPRPQPIAGTPPPDPSEKCADPKMIQQTCTLFGLDLERPPPVPPSRSYTVTGNTKLGYPQTRVMKTPFPEEGEGEVVLLKGETVLVIGASPRRGHLLVEHNNTTLHVPYQFMELKPCNINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI13</accession>
    <name>A0A232FI13_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Immunoglobulin I-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000165">
        <property type="protein sequence ID" value="OXU30381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI13"/>
    <dbReference type="STRING" id="543379.A0A232FI13"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012127336" description="Immunoglobulin I-set domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin I-set" evidence="2">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="265" mass="30228" checksum="533C3C07C61BC3B3" modified="2017-10-25" version="1">MFTHRCSSSVVLLSTVLLTAYVASTPAVGREKRDILVKPDVYRCKKHKEVTLTTNAEKHGDKVYQAGQLLEAECKIVDVDSTHEISIYLDDEPLELLKSDDPNNRKASRVLAVSDNGKRLRCIASDNNGKPEHHEALREIEVYFPPQPQAQADVERCDYKIGENAVINVDVYANPRPTFKWSANPDKYMKDKDYDKSNRFRIQSTEDLGKGHWLVKLSIDELRQSDFERFYYLQASNQLGSSSYVVFIKIHCDEEQRSNSLANGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FII8</accession>
    <name>A0A232FII8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000171">
        <property type="protein sequence ID" value="OXU30340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FII8"/>
    <dbReference type="SMR" id="A0A232FII8"/>
    <dbReference type="STRING" id="543379.A0A232FII8"/>
    <dbReference type="OrthoDB" id="73348at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8563" checksum="6592DC690A4B40F2" modified="2017-10-25" version="1">MARGQQKLQSQAKAAEKAAKAKKQQGHSANDQKKAAQKALVHVCSVCKAQMPDPKTYKQHFENKHPKNDLPDDLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIX0</accession>
    <name>A0A232FIX0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP157 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000155">
        <property type="protein sequence ID" value="OXU30490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIX0"/>
    <dbReference type="STRING" id="543379.A0A232FIX0"/>
    <dbReference type="OrthoDB" id="166611at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038844">
        <property type="entry name" value="CFAP157"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31954:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="303"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="486" mass="55966" checksum="A56078F6D3830850" modified="2017-10-25" version="1">MKKKGGKKEKKARKKNFVNELETVTFEQQILENNRQLARLRSRNEELEAEAETLKERLDQLEENKADLTAHLQRALRKKTEEAEELQERLVALEKLRKEEEQAFKKKEESMEHEYKTMENNLTAEIKLAAGKLNALEDWRLARIDLMNKFEDQEKRMAEQEIRHKESLYEAEKKLIIGKAKMQNELEKRLTELAESFRAATNLRLADATQRAVRENVSLHQELNGLLNHCRELDARMQSHKESERGLRLQAALYEAEARLALNKLIKQNRLIERLAQEQHLMSRAIGRARRAEEYAIRGEQALEQARLSCAEARDRARVLEQNVETSRGSRDDSMREARDNCREIEKLARILAEAKEAIRQALQVLVQAEMSDRGDEQAEDACSSCFLDLKEKLLHALLDILASYQDPNDFERVTEIESETVIENLYEFGNLGLIPSFGRAPEATSSAPSKRDIPSSSGRRISHQQGEGKRVSESSFTVADCSCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ83</accession>
    <name>A0A232FJ83_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000117">
        <property type="protein sequence ID" value="OXU30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ83"/>
    <dbReference type="STRING" id="543379.A0A232FJ83"/>
    <dbReference type="OrthoDB" id="10015560at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39074">
        <property type="entry name" value="AGAP007547-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39074:SF1">
        <property type="entry name" value="AGAP007547-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="287" mass="33292" checksum="2E5C880C8C0EAEB2" modified="2017-10-25" version="1">MEIMLKKVLCTMLATCGSNIFGFLAPLVIPPLHIAFIYYFWQDFARDVDKQYCSCSCWDTVFKGSYESGVASYKHMYFNATSNTLKIWVTIVLGVIVFYETVKHLAWLGFQKHLRWRMFILFMTAVFSHYYSWWVYINYWNDDFYSQWYHQFFFSATELISTILVVHLADDRNPITRRKAFGIVSIALLHILAGGWDQFVTNVVRGEGYAHQVVRDLGFMIPDVLHVIIPLCSLETKGAYSLPGAGLRDPDLKTDLILFRPMLMLYFIKVVSFTSIHESKTAITTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJC8</accession>
    <name>A0A232FJC8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleolar protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_010235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000145">
        <property type="protein sequence ID" value="OXU30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJC8"/>
    <dbReference type="STRING" id="543379.A0A232FJC8"/>
    <dbReference type="OrthoDB" id="6502630at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048897">
        <property type="entry name" value="Nol11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012584">
        <property type="entry name" value="NOL11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20998">
        <property type="entry name" value="Nol11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08168">
        <property type="entry name" value="NOL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nucleolar protein 11 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 11 C-terminal" evidence="8">
        <location>
            <begin position="391"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU30589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69453" checksum="5D1D1B85A440A7BF" modified="2017-10-25" version="1">MARLSSYYTLCPLIDQQNLLGVENDSDPGCAIVTLGKNIVIRYKLQDTKQVSSWSTKDRLTTQVIYDDTSNKYAAVFNGKNIRTWQEDETNLDNVKKFKFPSPIHAILSFKGISPILVMQNGATVSLEWAIENRKTWSNPGILKPNETISSCQLVCVKNEIYMCALTKLENVYNFVVVPLNGENYTGEADKVVRIDMKRPSEKLIGHVVMQDNKNAYLLTLWSHGRLYMYPLITPTTESIPGTLISVITAVNTKHPVVMVALNETTIAAYGADAHEEGAVLLIYNVQFKLVQAIQKLKLYTNDAKLWKIEDKLLLAANRHLAIAPYSLAVQRIEAMLGSTLHCNNEDSTEDNDIEIIQESTIADWNLAASLDKINDGLPLHELDSRIATQVSTFKREGLSDAAIQRNLIPQLIESKDISSILWCLDHLKELPEELLIQLLGFCLRTYNNVTSLPQNGHTGSPSTHNESLFDTFLTKILSICYTDVSIISYLRAGLNFDQILELLNYMITKLGDDENHTYSSETSESEHNFNKQLYEWTKLLLDSHYQHYVLSQDTQVLPLLNKLDEALESHADLIKDLQSLRPMIHRLMRGKILKAIPNDVNRFYSIEEVKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJR4</accession>
    <name>A0A232FJR4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sugar transporter SWEET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_008774</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000120">
        <property type="protein sequence ID" value="OXU30780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJR4"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000004">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF5">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="23675" checksum="8E0F1E67BC0080FD" modified="2017-10-25" version="1">MGFEDYKDLVGTCAMITTMGQMLSGTLICKDVYKQGTSKGTDPMPFIGGIGMCILMLRYAFVVGDPIMINVNVFGVATNVAYMAVYYLFSPDKLGTLAQLAKATAFVAICLGYAQIEKEEHLEFRYGVLTTGLLLALIASPLIHLGEIIRTKSTAILPFPLILMGTLVSFQWLLYGLIINDAFIIFQNAVGFTLSAAQLSLFAIYPSTPVKVDKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK75</accession>
    <name>A0A232FK75_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000109">
        <property type="protein sequence ID" value="OXU30899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK75"/>
    <dbReference type="STRING" id="543379.A0A232FK75"/>
    <dbReference type="OrthoDB" id="7700848at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="19059" checksum="2D8FC0E335AED515" modified="2017-10-25" version="1">MKKITGGYIIPPKSPELLDRIVTTLFLLQLEARPDVFVDLYNSCLDEGTFPKNWKKQRLVLLPKGDEQPGEASLYRPLCMLDTLGKILDIKSSAEAKGFERFFKNGFSNYNQRDQVLRFHGRAVTIRKEIHLGWRHFKKNKYFTMHEATCNEKVLYLDEKMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKF2</accession>
    <name>A0A232FKF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="NNAY01000096">
        <property type="protein sequence ID" value="OXU31010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKF2"/>
    <dbReference type="STRING" id="543379.A0A232FKF2"/>
    <dbReference type="OrthoDB" id="253091at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14515">
        <property type="entry name" value="DUSP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF5">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="61"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="213" mass="24134" checksum="1348559BE2A14698" modified="2017-10-25" version="1">MTDMAEAETEKDFRKPLPDGETTVQRLVHALHTTRTGYKRMPGFDPSIDNVEYYRAQQTVDCDEVFPRIYIGDGITAKNKPYLQRIGITHVLNAAEGKKFGMVNTDANYYKDTTIKYLGLRMLDLPSTDIAQFFFTAASFIEDAVQSGGRVYVHCVQGVSRSATCVIAYLMIKKGMLATDAIRTVRLSRDIHPNEGFLRQLATLDNQLRRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKR4</accession>
    <name>A0A232FKR4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat domain phosphoinositide-interacting protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">WD repeat-containing protein 45B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000090">
        <property type="protein sequence ID" value="OXU31089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKR4"/>
    <dbReference type="STRING" id="543379.A0A232FKR4"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000083">
        <property type="entry name" value="WD repeat domain phosphoinositide-interacting protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="366" mass="40997" checksum="8FDCAE47FEFBFA06" modified="2017-10-25" version="1">MNLSSGNPNGNGLLYAGFNQDQVKKEFTVSSEITNIVQELRSMLHSRCFACGMENGYRVYNCDPLKEKERHDFAEGGLGYVEMLFRCNYLALVGGGKNPMYPTNRVVIWDDIKKSPAITLEFNAPVKGVKLRRDRIVIVLEGVIKVYTFTQNPQQLHVFETNPNPRGLCVLCPNSNNSLLAFPGRKNGHVQVIDLANTEKQPLNIEAHETPLSCIALNLQGTRLATASEKGTLIRVFDSQSGAMINELRRGTHHANIYCINFNHDSTWLCVASDHGTVHVFAVEDQKLNRQSSLASATFLPKYFSSSWSFCKFQVPDGPQCMCAFGTDNNSIIVVCADGSYYKFVFNNKGECTRDVYEQFLEMSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL17</accession>
    <name>A0A232FL17_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0489 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000082">
        <property type="protein sequence ID" value="OXU31148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL17"/>
    <dbReference type="STRING" id="543379.A0A232FL17"/>
    <dbReference type="OrthoDB" id="418142at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225">
        <property type="entry name" value="MISEXPRESSION SUPPRESSOR OF RAS 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13225:SF3">
        <property type="entry name" value="UPF0489 PROTEIN C5ORF22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12640">
        <property type="entry name" value="UPF0489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12697" checksum="905789F66555E2E8" modified="2017-10-25" version="1">MKCFVYYLKVLPYIYRCIGSKHLPFEGNTFIHLDSHPDMLVPKDMNADTVWRKDDLFEEISIENWMLPAAYAGHFTNIIWVKPPWAHQMVDGVRNFLIGKHKESGCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL81</accession>
    <name>A0A232FL81_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_001038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000053">
        <property type="protein sequence ID" value="OXU31506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FL81"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="728"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="851"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1194"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1658"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="552"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1658"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1683"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1724"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1743"/>
            <end position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU31506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1962" mass="212861" checksum="2BEC3513E0AE77E3" modified="2017-10-25" version="1">MFHFLETGTKDELLNRFIFVLQVNNKNEWVWLCEEFHLPSGCVNSGVGLKQIYLRYLDRYEKVHFLGEDGHQADDDDEDSRHRKWNARSLHSVPLTYNHHQHNVAESLREYNGLSSDLYKPSNYDKLALSLLSPLPNEQDFAINVCTFLSNEGKHALRLDKYPRLINHLLAHAGIFDSPGTRQLFIEVYSRVRNYSINSFWPDVLDGQDVLDLTDERIFIKKPITANSQRFIRRRQEKERQRNQQSDVVTLDDASCPMDIDNVSIIEIFRLPCYIYVCHWLLTTFDSLQGSLECDRLENGIEILEERLNPHLIDENSTSSNTSSTFKDQNQNSIKFEDDDKDLFCVGRTLGTQDPYGQRVLQIASILRNLSFTPENAAVLGRSRSFLRFVLLCVRARWCNLHQLGFDILGNIANEIILKDAGERLTSVILSSVAKGIDSPDRFIVISCLEILNKVSQQDLNEETLTFGLDDSVYELICRFLALSDIALLVYTLECLYALTSLGERPCTSVARVRGAIDTLVALVTVEAQSYGPKACILMRVVETVSSVPASQQQQQQQQSPQVAQQSSPSQQQQSQTISAAAAAAASSSVHHHVSTAPSQGAPMATSVSEPTGPDGQVSSTGSPSGSGQVTEVVAVRLAPHQMQQVKQQQTVQTVQAAQVAQVQAQSHTQQAQAQSAQPIQATPTKAIAAGGSSRPSTPKAAAAKAAANSLQQQHTHQQIIQENEQFALGWLKATFELSPGVRIEQEELYKKYLGCCTKIGRRGVIAPLHFPRCVRSVFGGTIGPNPIKGENTGTLYYEGIRVRANPGQVTYPLKGVTRPNVTGAQAAENASGNVVTIVGGTSNVNSAKVQQQRNDSTPIQVTPSSPILKAQLSAPPKPSVHPDSPLSIAPSSAATGNIFPIEPRSQVSVAHPHLSQALLASGAQQQAGQQQQPQQVQVIVKDDGRGGTTSSSIIKSLLATKVTVAGECMQAVAVATSSSCVSAVPAITNATGVVSSISANQLITSNQVAQRQQQQQQQRQQQMQQTPGAIIGTKTIINAKGKPTIVAVKKIQRLNGAKVIVANNGEKPEAMDTDNGLHATTNQQTQLAIASIVPPTSIDSSNHVTGVMRVYRGPATQQVSLTTASSTTGTGKQSNQQLRNVCTPIVEDSDSTNNSLASSSGIGGSRDCSGVGAEEENSLTSFEGILLNGAPSNLDIDAQDDGSSKDSSSIGSKEKPSQSMMLADLLERKVEKEPIMNGVLGKKDLVENHIKKVLKESPGDVKIKAEVSEDALIEAPARLGIKRSGSTVTNEADESCDAKKPKYSNGTTSPDPAVVDSTTISSIKSEEQDDEKEEKVTVSSTAANLYAALAADIIDDETDLEEPSVKEEIKPVVKEEIKAEPSTPVAVKQVAVSQEQLQPVQQQVQVQTQVQPVQVQTVAQAQPQQHHPTHQTIAITQQQLQQQLQQGLIVAAAPRQIVVQQTIQSNNQIVTIPAMKSRPQHQIQPQVLQVQQGPGGQTHYVISGGVPGQNYVLAQPQTALVQGQAQTVLVAQQQGTNAKTIIILQPQAAAQPQAQKMVAVTPQGQQVVVTQVPRPLMQSPAMGNIPPPLVPTSGAISQASIVMNSAVAQQIQQQQDQIVSQQQTITQQKITQVQAQIQPAANTVTVVQTQQAAAVATTAGNSVPSRVVTPTPASTPPPTRPTTPRQAAATNQAPVTAPTKPQPQLIAPSPRTSTETKEVVMVTAATSTEPENTESTEGNNTKKSLTSQETSTSRPQSPATPMKTITVTLERNAFLCEWRGCFKQFKNPRKVYLHVVEAHCPTGNEETLCQWASCDGLKRRRFSLMTHLFDRHCCDEIMLMRRKQFDQSGKTEYLTSKPVASPTHHPGYAPNAALHAIKRHALEFVNPKELMDDNEGPVTKSIRLTAALILRNLVIYSAHGRRHLRAYEPHLAGVALSNVESSRTIAQVLYDMNDQSSSGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLC7</accession>
    <name>A0A232FLC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000073">
        <property type="protein sequence ID" value="OXU31258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLC7"/>
    <dbReference type="OrthoDB" id="7698093at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14538" checksum="DEB936AA317682FA" modified="2017-10-25" version="1">MDSEATKEEVEAAINGALRMPDNSSCKIRKPVKVVRCHKCLGFGHLKHKCNRSTLCYKCGGADYRMAQCWIEASCFLCKDDGKKEEGCKHVADSSSCIVFRSSLDTAKKKERGALKDGDGRRKVDDRMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLD7</accession>
    <name>A0A232FLD7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLD7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="566" mass="63121" checksum="85F18BE2873A87DF" modified="2017-10-25" version="1">MQQATVETAHAAAMSALLRGREARSMKLSISRLAVYGLRVRGSVEVKRDRLLRACLHGHKPDVPWYPWDMAEREEEYAESEIERVVLGKKTVEMKERKTRRANERPMPISGSHSSESKNGGNQATGPEIEFGRRAIPSLPVVTAITTNVQMVSTSQAKGTWVTTTASLPQRPIATAAHSTERVCRSGTPTAIISGVDWEKKLKGRSSGESSAENSDKRSNKLSELSNQFNERAGRIGEYQAHGMTYEQAREYALRDEIEREGERVFHETLEEKRVKQEEEELDIEHQFRLHVAREAARARVQQIYEVDRRIKTLSREDERRPKGFHRSISGETDAALPVGTGRDKKLKDHRRSQPVSPGKQPGMARLGSRVTFSPSPPEVFPMSNNDAEESWRVEELSKIEKGLEMLLGEIDSEESRRKWELGDTGRIETDEPGKWRNTRWTDPHPSPPPRASGSSSAGPVEEVSTRVSKMEEHQVDGQDPHPSPPPRASGSSSSGPVEEASTRVSYAQAVKSSRPQRAATPPNLMAQTTPSRGLDNLGRGMVSLKIGVATPRLRLPIYNIKSNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLG8</accession>
    <name>A0A232FLG8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000066">
        <property type="protein sequence ID" value="OXU31349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLG8"/>
    <dbReference type="OrthoDB" id="7693386at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012827820" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29699" checksum="AEC2A71A5FA1D250" modified="2017-10-25" version="1">MMSKVKIALTVLSFAKLVFGEVHYQSRIINQRVVHYENDYIDFGVRYFGDEGIPYLILKDEITPYNDLDILLYARIYDHAPNYLVKAPLSLCKLLHDESVYEDHPLTKQFNVAQMFNFAGRSCPIDSVGNPNPQNPIPISYRSFLASPQPIVRLSPYIFPANFSLEQDIGCGYMNVEAKLLKCDDGTDANGETHERNCETLVKIVTLAFLMNDACSTDKSFIEMISDGLTDEPIVLTPDFPAPGQINEAWMQNNNVDPHGSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMG4</accession>
    <name>A0A232FMG4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000036">
        <property type="protein sequence ID" value="OXU31710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMG4"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="68" mass="7553" checksum="69BB6A6460E8BFBB" modified="2017-10-25" version="1">MVETKVVGYRRGNPMVTLDLTLNAFFKEPHSFIAGIERAVNFTFRMVCSVAALKVISMSCSQNETPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMG9</accession>
    <name>A0A232FMG9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMG9"/>
    <dbReference type="STRING" id="543379.A0A232FMG9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF217">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU31946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="232" mass="26265" checksum="6DA594960A033E2C" modified="2017-10-25" version="1">MDLSKQRMINGNVNKIYCQNNEYGCHLIVYFRQASGLRSFPIELSYLLSKIVSIPGIPEKQLSDLGRLSYHSFWKSVVLEYLDSHRVVKLGALDRRDHKGNGFSGHDIATYPTPKYQSPEEKEEKDTSSESASLALMNQTPPCVSTPVVTMPEKILRVKIRKKIRGRKIGGARRQILPMKHKTLPQQRTKLLKKKEVKDVDKISGHAAGTEQDIKDDTLNESKSIVTMSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNB3</accession>
    <name>A0A232FNB3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNB3"/>
    <dbReference type="STRING" id="543379.A0A232FNB3"/>
    <dbReference type="OrthoDB" id="9986793at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="41102" checksum="FD6DC4BAFC6BC401" modified="2017-10-25" version="1">MVEIKIVGFCGGSRMVTLDLTLKASFDASYSYVKIVNVITLNQYLDNDRGKMADYPANDIIDILFVLGEYRQNYRRSAVLYRERFPRRRHPNANTIRFLELRARRGYLRRQRLRRNIKDQTQNVCFLAILAMVHLDPHISLRTIRSELGVPRSTCKRYLKFSRYHPYHITLNQDLNEQDRQQKVQFRQWARNQIRNEPNFFQFMMFRCGCNRWIGRGGPIAWPPRLPDLTPLDFYLWGYLKDTVYSERPTTANDMRMRNQNACANIPLNLLIRTIKLWVLNIKFVSIAIKIPFEVQTQHITLKRSISSTKQGKIAELLVTENNGRKQKKLNGYNIDSIALRNLTKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNW7</accession>
    <name>A0A232FNW7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000003">
        <property type="protein sequence ID" value="OXU32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNW7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="7027" checksum="C71A1374756456E9" modified="2017-10-25" version="1">MRNTHLVPHYILCICILHNICLKRQDELEFPMVIPEIEDDNKGPVQVNNELEDQGIKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FP25</accession>
    <name>A0A232FP25_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoyl-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000006">
        <property type="protein sequence ID" value="OXU32117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FP25"/>
    <dbReference type="STRING" id="543379.A0A232FP25"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU32117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="167" mass="18589" checksum="9BB03804C1CF2B9C" modified="2017-10-25" version="1" fragment="single">MLRTTTSLRHELAKATLRSTVRSNVVRCLGTQCLHKRHQQRPLIHKSSRFALQPWQQNLRYYADYPDHIKVPLPALSPTMETGTIISWQKKEGDKLNEGDLLAEIETDKATMGFETPEEGYLAKILVPAGEKNVTIGRLVCIIVADEGSVAAFKDYKDDGSTVAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ECW5</accession>
    <name>A0A232ECW5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01011491">
        <property type="protein sequence ID" value="OXU16221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ECW5"/>
    <dbReference type="STRING" id="543379.A0A232ECW5"/>
    <dbReference type="OrthoDB" id="7699282at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="99181" checksum="2ED55209D68A224C" modified="2017-10-25" version="1" fragment="single">MDQTGAIHKQANADGFSETTFDRFQQGVFHREGTDRGRSTEQYEFPPAPLPNLLDGPRSNENVTRTSLGRGARVQGVRSEQNRRLGEHNRSSDMNLDETGPSRIEVRPTSRQRDERRDGIIERLFTQLSTSSMPNPTNNNTVPASSTFQNYQVMPDLSKNIQNFTGNESSTAAKEWLSNIESMCLLHNWPDNFALETARMHLTLGARDCTSTMPNPTNNNTVPASSTFQNYQVMPDLSKNIQNFTGNESSTAAKEWLSNIESMSMDQTGAIHKQANADGFSETTFDRFQQGVFHREGTDRGRSTEQYEFPPAPLPNLLDGPRSNENVTRTSLESRQRDERRDGIILRLFTQLSTSTVPNPTNNNTVPASSTFQNYQVMPDLSKNIQNFTGNESSTAAKEWLSNIESMCLLHNWPDNFALETARMHLTLGARDWFATRKNLVSTWKDFKQTFRKTYVRNDSTTARWKRMTERIQQRGETLQQYFHSKTKLCVDLGLGMSDTKEQILIGLWSRDLYHVMSSRVHGSVDDLLHDMLDYECASTLRAERMKAYNNSNTTTNRACLMKASVVLLNRYPIIYEQSELKSFGPESYCVKSPGYVEVSIQVDEAKVLGVKCPCLMKASVVLLNRYPIIYEQSELKSFGPESYRVKSPGYVEVSIQVDEAKVLGVKCPCLMKSSVVLLNRYPIIYEQSELKSFGPESYCVKSPGYVEVSIQVDEAKVLGVKCPCLMKSSVVLLNRYPIIYEQSELKSFGPESYRVTTDVTIPPLTVSLIETRINEVNHLLPIVKYDTKNQKVKKGASPCRSQLSRLPVMSVHLPREPVKKEDLNVGDEQPEAPTEAVIVELLNIANKYRDCIAFNVFEIGCARGIEVEINEKPGSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE00</accession>
    <name>A0A232EE00_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005718">
        <property type="protein sequence ID" value="OXU16580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE00"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="115" mass="12682" checksum="BD204D71CB56CB03" modified="2017-10-25" version="1">MKYSDIVFPDSVDDIHGYYSGCRKNFLAIPKKYIEMYEEKEEKKLQNTSTEKNANPVLIGAASTSKKANTEKESTQSTSMSVDLEENRASGEQASSVREEASDNDEANGDGSISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE63</accession>
    <name>A0A232EE63_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005530">
        <property type="protein sequence ID" value="OXU16647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6598185at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF141">
        <property type="entry name" value="TRANSPOSASE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU16647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1160" mass="133541" checksum="F274D547B2495780" modified="2017-10-25" version="1" fragment="single">MKTNLETGMRFSPRKNSSKTRCCVFGCQSVAREDPTVRFHSFPKIGEIQVPIINKHNCTEYVDRRWAWEKVLKIKNLTSTSRVCSLHFKKDDYILPDMPAKNRYLRKPAVPSVNLPDLEPITEETVIKKNNDLKRTERVRNLSLEKKHKKVGQKNLNKNEYLENNLVENERTSNECLENIENIENESVEKAILENRVSSEIEHPASLHQDKAVQTKLYETEDKEVQVLFENYSNFIRTDKDLSTMTGLPSFHHLYFLENVVKIAMPASASLYGKSFSKLSTRFPTYILYGMIQVMFQVYSEENCRKIFLRMLDILSAGLKHIIYWPEKDEILKNIPECFNGFTDVRAVIDVTEXMRFSPRKNSSKTRCCVFGCQTVQTKLNESEDKEVQVLFANYSNFIRTDKDLSTMTGLPSFLHLYFLEKVVKIATPASASLYGKSFSKLSTRDRIILTFIKLKLNVSYGMIQVMFQVYSEENCRKIFLRMLDILSAXAVPSVNLPDLEPITEETVIKKNNDLKRTERVRNLSLEKKHKKVGQKNLNKNEYLENNLVENERTSNECLENIENIENESVEKAILENRVSSEIEHPASLHQDKAVQTKLYETEDKEVQVLFENYSNFIRTDKDLSTMTGLPSFHHLYFLENVVKIATPASASLYGKSFSKLSTRFPTYILYGMIQVMFQVYSEENCRKIFLRMLDILSAGLKHIIYWPEKDEILKNIPECFNGFTDVRAVIDVTEITIQSPKNLCCRLASYSAYKTTAVTPAGIISFLSDGYLGRSSDKAIFEESNFIKLFEKGDALMTDKGFLIDEICLKHDVKLVRPPFLKDKIQFSKEEVLLNAKITKTRVHIERSNQRIKVFKILSTKLPGFLVPRIEQIMTIICAIVNLNSLILKDDKFNHFIYWPEKDEILKKIPECFNGFTDVRAVIDVIEITIQSPKNLCCHLASYSAYKNTYTVRFMTAVTPAGIISFLSDAVIDVTEITIQSPKNLCCRLASYSAYKSTYTVRFMTAVTPARIISFLSDGYLGRSSDKAIFEESNFIKLFEKGDALMTDKGFLIDEICLKHDVKLVRPPFLKDKIQFSKEEALLNAKIAKARVHIERSNQRIKVFKILSTKVPGFLVPRIEQIMTIICAIVNLSSPILKDDKFKIFNIFNDIRNGSKFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEB3</accession>
    <name>A0A232EEB3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005424">
        <property type="protein sequence ID" value="OXU16683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEB3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="375" mass="44424" checksum="BE47A3F08D6B6B78" modified="2017-10-25" version="1">MSFFNISCRTCITESTVLLSKVEVLSRWLDKRDITIARLRTSTNATKYRCHQILPMVFGLNNSYGKIVNIGLQNTSVGSDTSIRLFDWFRELFDEIDRFFQAFSEDDMLDQRITFSRFYIRFMISYSDRAFELLEDDETTIRKDSGESRSKKVSKPSLVFKRVTFDRLKALPKIIDHRIKYLLKVKEAITIIVKELGDYSKDKLVNSENAQFTYFTSYNVERATRDFDETLFRELFDEIDRFFQAFSEDDMLDQRITFSRFYIRFMISYSDRAFELLEDDETTIRKDSGESRSKKVHKPSLVLKRVTFDRLKALPKLIDHRIKYLLKVKEAITIIVKKLGDYSKDKLVNSENAQFTYFTSYNVERATRDFDETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF07</accession>
    <name>A0A232EF07_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (cytosine(38)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.204</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA (cytosine-5)-methyltransferase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.204" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01005163">
        <property type="protein sequence ID" value="OXU16931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF07"/>
    <dbReference type="STRING" id="543379.A0A232EF07"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU16931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="369" mass="42093" checksum="EAF96DE73FB0A825" modified="2017-10-25" version="1">MLKTSLKMRVLELYSGIGGMHYALQESSVTGKIITSIDINTTANKVYRHNFPETANISRNIESFTVEEIAKLQIDCILMSPPCQPFTRIGLKKDSDDNRCLSLLHILQIIPRIESLDYILLENVKGFESSQARNEVILCLEKSGFNYKELILSPCQFGIPNSRHRYYLIAKRKGLKFIFDDASLISSIPEKVLELLPKSRYMSVPLEDGTHSSIKSKGKCFKLKYILESNVDQNFLIPGKILLKRGNLLDIRTAESNGSCCFTKAYSHYVEGTGSVFSPSSDFEIKKKFEEINKSSETPEDKMQALLDLKVRYFTPKEVSRLMCFPENFEFPKDLSNKQKYRLLGNSINVHVVSQLIYLLYFENSVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGS6</accession>
    <name>A0A232EGS6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004687">
        <property type="protein sequence ID" value="OXU17556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="140" mass="15038" checksum="AF79B07875C5A64A" modified="2017-10-25" version="1">MNAVCNNCRKTETPETLAPETSTLAVLTSAIKSTQEREKSARRKPSPSSGKSQVSVRTGPVLRTKSATPRVSPHHQTRLAASTPCANTRSGVRSSSSXSLSLSLSLSLSPSLTHTHARAKMKRHLKCMSPAPIFCEICSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHV1</accession>
    <name>A0A232EHV1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004438">
        <property type="protein sequence ID" value="OXU17898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHV1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="24" mass="2558" checksum="D03A4C8A57D3FE99" modified="2017-10-25" version="1">MVADWLAPFLLLGWSLARPGVGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHW6</accession>
    <name>A0A232EHW6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004429">
        <property type="protein sequence ID" value="OXU17911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHW6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7744" checksum="C4F870B175A692B7" modified="2017-10-25" version="1">MRWRPWRDDRASALQARGSRFKPGVRHFFVALFTRNNKCFEKMFAMVENCVFKISTTFTFKVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIU1</accession>
    <name>A0A232EIU1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004155">
        <property type="protein sequence ID" value="OXU18280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIU1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="32" mass="3341" checksum="0ACEE81F98A8F27B" modified="2017-10-25" version="1">MSGVLSGMPAPIGSIPAVVVLMLWVMFLPTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ37</accession>
    <name>A0A232EJ37_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004131">
        <property type="protein sequence ID" value="OXU18328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ37"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="160" mass="17932" checksum="67F2B93A8539FEFD" modified="2017-10-25" version="1" fragment="single">LHVFSDASSKAFAASVYMHFSLPDGQAHVALVMMKPLMAPLKPLANRTINFCGAQVGRDKQAYHVRGVAMGSDESEPRRPRDTMEKQNGATVGPDFLRNPEANWPVQGRIFDETKKNMTRWNSLMGHFRSTFGVLRIYFQSTFGSPQPLKRSSFGDQVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJH7</accession>
    <name>A0A232EJH7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sarah</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003995">
        <property type="protein sequence ID" value="OXU18519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJH7"/>
    <dbReference type="STRING" id="543379.A0A232EJH7"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007617">
        <property type="term" value="P:mating behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000092">
        <property type="entry name" value="Calcipressin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29477" checksum="5D4EC72187D7BFA6" modified="2017-10-25" version="1" fragment="single">QKYILEQILKTRNKKMEEKRSKSTGEDEESEDSENIIINEVDGLPNVHPNFEQLELNCEKNDDRSNEDVSSRTLEDLIHDEDLPMSVIVTNVDPRVFKSDEFKVEMEQLFKQFGQDATFQYFRSFRRMRVNYKSPSAASQARIQLHQTHFGETDINCYFAQPVTPIDVEDRHLHPPAPHKQFLISPPASPPIGWEPREEGEPLVNHDLLAAIANLTPGESHELHPGGSNQPGIVVHICENAANAVKSAPRIPHTRCPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK86</accession>
    <name>A0A232EK86_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_009131</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003850">
        <property type="protein sequence ID" value="OXU18763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK86"/>
    <dbReference type="STRING" id="543379.A0A232EK86"/>
    <dbReference type="OrthoDB" id="10063348at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09923">
        <property type="entry name" value="SH2_SOCS_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF16">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="442"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="550"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU18763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="599" mass="65225" checksum="0B412C53D8DC3BD0" modified="2017-10-25" version="1">MLTVICPNCRHGFPVPGCCSGNNSDVTTNTTTTTTTTVISFDQQQQTPIVPAPLPTSISIGHSSGGGMLLVDTTPAQFQQPMVTISTQCGIQSGGCLIQSSNAEVMLQHGNAGRLELRSKMSGGGCLVQKRIEPDYYHHESSDSKEAAQGRPLLISEEQLRSSFEQAAEFHRSHSTTARLDPPPSGCQELPGTRRESPAFTSTSFPQQPSNNQQQQQVQASSSPECRCCCFHRCCYTYSRNSSSAAGTGNSPPRPCCGEGKNCPRSSETAASEISYPPPSAPQQSGSIDAPQYAGDVRIQVNATVHLPCTSSTTVSSCTFNITASTSGSSTPTSNSDPSSNISSNVNVNRLRNNFNGGGIVTIDNSSPSNSESSNASSVGSNVSVIGSVANNNAVNNNREDMPGTPISWMALCPWAFEQNHLPEKDMAKLADVRKTLQSCGWYHEGLSWQQSENLLKDAPIGRWLLRDSSDSRYTFAISVQTARGPTSVRVFYFLGKFRLDAEPRLASTMPLFETPIKMLEYYCEYSKRMDEHRQEVWVDYSGQVYSQIYLSEPLVKEVRSLSHLARIAVNKAGGSLKKEREKLPPLIKNYLKEYPYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKH0</accession>
    <name>A0A232EKH0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003791">
        <property type="protein sequence ID" value="OXU18864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKH0"/>
    <dbReference type="STRING" id="543379.A0A232EKH0"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF84">
        <property type="entry name" value="ALPHA ACTININ 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU18864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="154" mass="17173" checksum="31612786B7BCD8CC" modified="2017-10-25" version="1">MGERRGTKALELWCRRITDGYPGVNVQNMTTSWRDGLAFCAMIHHFRPDLIDFGSLNKDDIYGNNELAFRTAEQQLGIPALLDAEDMASCSVPDRLSILTYLSQFYQVFGGSSPSKLALNRTSESSGARSVPESPQPKEDSLDLMGQYKPEIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELH9</accession>
    <name>A0A232ELH9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003556">
        <property type="protein sequence ID" value="OXU19205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELH9"/>
    <dbReference type="STRING" id="543379.A0A232ELH9"/>
    <dbReference type="OrthoDB" id="10254947at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="732"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU19205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="832" mass="92962" checksum="0F30583F590188CB" modified="2017-10-25" version="1">MEAAVEVPPKKPRLKQNLQLSECIRQFELPQQYPSTITERLAKPGSQKSTATIQTKSMQNIISALPFPGKMKFIPNKEVLISDSLQKLKFKLPDGRDVGEVKIVLPGQDEKPQTKVITMSKIGKNNEKPITWTIKSPGDSHKPRIKTITKLSNGLPIPDDSLTQSDDTSLSKMKVQFLSGNNNSSATNGIKNVAMVSNLKRLSKSDSNDSNKQNIIVHNTDGGILKKLVIENPSMLMDKQNSQTQVFLKKLPGSQKMVMLQRDGNQLMNKPLSLKPITQSNLQSHNIKNNAEKIIFKSTINGSIIRKKEPLPTESTNHHEKKRSHSEINLDDCNFNGNSSTQSINDDQRRKQLKLNDSTKSTGAIGLRKNIMVIVPNEEAEKLSRPSSSAEMNNLDFLQDDDIINLNDEAISEETISNIKNSELSDIRIDEVHSIQNEALEVNINQSSSVNNDKNAKSQDRINQLNILKQAVLSVQDADLRAKALKALKDCGIKVKKTVPAKRPMKMISESTTQTEVFSLLKNDEFLQINNESEDIVKIKHSHKMMKQPINTLSSRKTNHNVCPESEQKEFKMNLDKSLEKLFPACKGITDVKDAFEQNKKAYARAVLKHLEKDYKAAKKHDDDGLLGIHKAVLNNSIQEVQRHMLMLKAAKQHIDVPTLDNKTSLELAVEFEMDSQIVKILLDAGAQPVSSKPIHDSAVILAAKTSSKILHLLLKYITRSNRSLLNRRNSEGLAVIHYLAQNGNLEGITELLKHGVDVNLQDSRSGRTALFYAVETKNSDIPQEVFNDIAHKLLEHEAVSNIPTFSKHSVLSMIDDVKSHALKIALNKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMA9</accession>
    <name>A0A232EMA9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_014476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003385">
        <property type="protein sequence ID" value="OXU19499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMA9"/>
    <dbReference type="STRING" id="543379.A0A232EMA9"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="442"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="59446" checksum="796D3F1A6166EDB6" modified="2017-10-25" version="1" fragment="single">NIEDFVIENNIIKGVDQDFGECSGIGEHLLSTLSSKPDHVAQIEAETGKQTTFAEMKDRSVRCGIWLKKQGIGANDIVVICSKNNLDLYAPMFGTFYAGGTFSGWSPFIASPKPVQRLMKLFKPKIVFAGEDVVDILHKAAKLENVKTKFVVFGRHSNFKTFHDIIKIPSEEDVHDFRAEKVNLKDNAVIILTSGSTGFSKGVQHNYENLFKIIVGLTPYPMAGVALWYSTCDWVTGVTFALQSVLLIGTRIMHTQFDVEETCKVIEKYKVNLMLASSVIMASMLKLNVFKRYNLQSLKFVCTGGSKTNALALKGFHDALPNALIVQMYGMTEIGRSIASQTENSKSIGSAGFVISCNQLKIVDIENGESLGPNKPGEICIRSPTMMTGYFNNPEETKKVLDNDGWLSTGDKGFYDENGEVHVIERLKEMMKYQNHQISPSEVEQVLLSHPAVMEVSVIPIPHYLDGDWPIAFVKKVPEFQVTEDELVQLSISVFGELKKLHGGVKFVEQLPKMPNGKINRSLLKEMAKAMSINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232END3</accession>
    <name>A0A232END3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003191">
        <property type="protein sequence ID" value="OXU19831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232END3"/>
    <dbReference type="STRING" id="543379.A0A232END3"/>
    <dbReference type="OrthoDB" id="2434756at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="218" mass="25341" checksum="84484B2CD77A9C32" modified="2017-10-25" version="1">MGKTASRLTRPLKNWNIENRAHKVISKEKPTVAPTYSSTQKQIDLVNQLDPEYRERSRKKDPGLDDNLRQVFVKTNSTEVQEIDSRSNPNRPLPKEKTLQEGFEFGFYESTVVKDGKVSLRQAMEFINNHKKDPEKYTVEAIAKEYKLDSKLTANILEFYKIFEVHDTEKNHNKDVVARVPISQRSGITVKHPIKPKRVEPKLDEVKKTIVLRQIEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP10</accession>
    <name>A0A232EP10_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Copper type II ascorbate-dependent monooxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_006430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003041">
        <property type="protein sequence ID" value="OXU20067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP10"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016715">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU20067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="18917" checksum="FC1D50927D3E661B" modified="2017-10-25" version="1">MFRFGGNKGKLRPELYLCTPVKVNTIDTYYIVGFEPNATMDTAHHIILYGCSKPGSSKPLWNCGEMSDSSDTSMTIASPCEDDSEYDKSCPTYEGYRVRVDKGEREGSIDLEVIRVKKMFNCVAVEYILQVVDIEAKQQESQDRTLWKDEVNPCMMRGTMLDDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP76</accession>
    <name>A0A232EP76_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="5 12">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_004697</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5 12"/>
    <dbReference type="EMBL" id="NNAY01002990">
        <property type="protein sequence ID" value="OXU20165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP76"/>
    <dbReference type="STRING" id="543379.A0A232EP76"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 12" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="179"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="484"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="661"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU20165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="950" mass="108428" checksum="731C606EEB97F916" modified="2017-10-25" version="1">MPWLQGDLAKREIYPSLWYLYRDQLLPPKTKIYGYALSQLTVADIRNGVVPFVQVSPQEEKLYDEFWSLNEYISGTNDADADYDKINRIISEDENDENEADRIFYLALPPVVFPSAASHIKRACMANKGATRIVVEKPFGRDSESAEKLSKHLTALFTEEQIYRMDHFLGYEMVQNLLSLRFANKMISSSWNKDNIAAIEIDFKENFGVEGRGGYFDSNGIIRDVMQNHLLQIMSLIAMEKPATTHPDDVRNAKVELLKKTKAITLDDVVIGQYVKNPESADPRERIGYRDDSTVADDSIASTFALTVLRIENERWSGVPFIIRAGKGLNINRTEVIIQYKNVDEDLFDGQSQRNELVIRIGKTEALQAKLMSKTPGIASNLEKITVDFDYIKEYPNLSNPGAYERLLLDVFRGTQLNFVRSDELGEAWRIFTPVLHAIEDMKIQPIEYKFGTTAVSTQECFAYVAKSRDVARTDESSVPHAFVTLGASGDLAKRKIYPSLWALYRDGLLPSKTVFYGYARSQITVDDLRKASEPFIKLKPEDKKLFDEFWSRNHYINGTNDEIADYDKLNQELSKFENNGEGNRIFYLALPPSVFPSAASQIKRACMAKGATRIVVEKPFGHDSESSEKLSRHLKSLFTEEQIYRMDHYLGKEMVQNIINLRFANQIFSSSWNKDNVVAVEVLFEEKIGVEGRGSYFDNYGIIRDVMQNHLLQVLSLIAMEKPLTNHPDDIRDAKVDLLKSTKSIVLNDVVLGQYIGNPDSKDPKERVGYREEPSVPDDSLTPTFALTVLRIENERWNGVPFIIRAGKGLSEKKTQVRIQYKNVEDDLHDGQAERNELVFKITGEAVEMKLMSKTPGITSDIEPINAHFTYSEEYENLNNPEAYVRLILDVFHGSQLNFVRTDELSEAWRIFTPVLHEIENRKIRPIDYKFGTHGPAEADEAEKKNNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPD5</accession>
    <name>A0A232EPD5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002971">
        <property type="protein sequence ID" value="OXU20201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPD5"/>
    <dbReference type="STRING" id="543379.A0A232EPD5"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17431">
        <property type="entry name" value="MFS_GLUT_Class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000029">
        <property type="entry name" value="solute carrier family 2, facilitated glucose transporter member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF128">
        <property type="entry name" value="GLUCOSE TRANSPORTER TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="219"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU20201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="703" mass="78821" checksum="AF405E1B9D8C3B4D" modified="2017-10-25" version="1" fragment="single">RKLEQHASRPKRSAEASADHHHHQQPRHRAQSSQQQHALRPSSISYQGEIGGLEARQRQASTHSTAPRIPRHGVRPARHHFGPRGSFSNETQEEVQEEDEATLRELLISLQKQVSVMSMNLSAKLDELQRGDRQLETTVALCEIRTQLQELTKSVESCQSEVSEVKRDMVAIKHELDTVQQVKEEIEELRSYVDRLEESSHRRKLRLLEQGLTFFLSYAILAAVLGMLQFGYNTGVINAPEKNIEYFMKDVYKDRYGEDISEDSVQRLYSLAVSIFAIGGMLGGFSGGIIANRFGRKGGLLLNNVVGILGACLMGCTKIAHSYEMLFVGRFVIGVNCGLNTSLVPMYISEIAPLNLRGGLGTVNQLAVTIGLLVSQVLGIEQILGTNDGWPVLLGLAICPAVLQLLLLPFCPESPRYLLITKKWEEEARKALRKLRASNQVDEDIEEMKAEEHAQQAEATISMSELICSPTLRSPLIIGVVMQLSQQLSGINAVFYYSTDLFTTSGLPHERAKFATIGIGIIMVIMTLVSIPLMDRTGRRTLHLYGLGGMFIFSIFITISFLIKEMIDWMSYLAVVSILGFVVFFAVGPGSIPWMITAELFSQGPRPAAMSIAVLVNWIANFLVGICFPSMKNHLENYTFLPFSAFLAVFWIFTYKRVPETKNKTFEEILALFRHGNGRKWRNFVHDTVLSYGSCFVERRAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQG9</accession>
    <name>A0A232EQG9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002769">
        <property type="protein sequence ID" value="OXU20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQG9"/>
    <dbReference type="STRING" id="543379.A0A232EQG9"/>
    <dbReference type="OrthoDB" id="7553767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="83182" checksum="233E18606D3C8D2A" modified="2017-10-25" version="1">MARKKTSGKKELPKFLPFKTVAELFAFQEISQEDYNDVVDYLEYLGGYNASDAAAIYLKQCFQPTADLVEKVTWLGSRKNGISALKDTRFVQACEATLKRMARKKISGKKELPKFLPFKTVAELLAFHEISQEDYNDVVDYLEYLGGYNASDAAAIYLKQCFQPTADLVEKVTWLGSRKNGISSLKDTRFVEACEEAMAENKKFGEPAKTDLATAMTKALKCVKEEYCCRKSKRAAGIPLQNGLPLQRRRVEEDKNNGIDDGDELGDDDEPGGGEVGDGGLGNGEVEDGEVGDVRGQCFQPTADLVEKVTWLGSRKNGIRALKDTRFVQACEEAMTQNKRFGEPSKTDIATAMTKALKCIKEEYRRRKAKRAAGIPLENGPSVQRRRVEEAKNNGIDDGDELGDDEPGGGQVGDGGLGNGEFEDGEVGDVRELANDEFGDELVNGYGEFSNGDFGGDGNDTEELMGVGGQYNDGEYGDDAGEGEYGDDDDESDRTALVSDHDEERSNDPDNAAIFEYLFLNKCGYNASDAAAIYLKQCFQPTADLVEKVTWLGSRKNGISSLKDTRFVEACEEAMAENKKFGEPAKTDLATAMTKALKCVKEEYCCRKSKRAAGIPLQNGLPLQRRRVEEDKNNGIDDGDELGDDDEPGGGEVGDGGLGNGEVEDGEVGDVRGLGNDGEVGGGSFTDGYGELSDGDFGGDGNNIGGDDNDIIGDGNDTEELSVGGQKDDENEYGDDAGQGEYGDDDEERPHCPYQRSRRGTQQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQM3</accession>
    <name>A0A232EQM3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_013728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002725">
        <property type="protein sequence ID" value="OXU20689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQM3"/>
    <dbReference type="OrthoDB" id="7696577at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="382" mass="44463" checksum="B546A5D1123F07EF" modified="2017-10-25" version="1">MDFSNLLSHMMKGIEECREKNPNPEIILENISVFFYFQGVTAKFFTAILTEDKLKYVYEEVMKDWKRFTDKNEIAILCQFAQVGRVLTVVWSMYTVISCVLFVTMPAVIPMILNIILTRNETFKKSLCIYCEYYIDQDKYFFYIFLHHIIAGVVTIFLTIGIDTSYVNCIQHVLTLFNVSRLKVAFDTICHFKKKDCNLKTLENHAHSYVVNSIRLHQRSIKLSSRFVDTIQSAYNVVFFIVCALLLFGISTFTVDLIWNLHNPINLMRIACLWMGTIMYMFYSNWPGQKLIDSSNELFDAIYNISYTCGWFEFPMKTKILIRFMLLRSIVPCRLTAGPLLQMNFESCSLVSYTSEDFFNLINSSNILRSAMSYFTVLATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQR8</accession>
    <name>A0A232EQR8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002725">
        <property type="protein sequence ID" value="OXU20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQR8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="81" mass="9644" checksum="96A0DED9E66F4CAE" modified="2017-10-25" version="1">MAILRTFTRIGRLLTLIWSVYTIINAILERNKSFDKSLCIYCEYFVDQKKYFFYIFTYHIIAGIVTIFMTLGIDTSYMNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERS0</accession>
    <name>A0A232ERS0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002569">
        <property type="protein sequence ID" value="OXU21031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERS0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="7127" checksum="F658BEECD01BCA50" modified="2017-10-25" version="1">MSLFCDLCVENGLRNIRREQIGTRAIMSNRAYVYTQPQRNATFVEESGFWIEWTRQFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES52</accession>
    <name>A0A232ES52_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002493">
        <property type="protein sequence ID" value="OXU21185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES52"/>
    <dbReference type="STRING" id="543379.A0A232ES52"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="451"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU21185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="580" mass="66053" checksum="F3BBD23D3E910AE1" modified="2017-10-25" version="1">MAKKGKKRQLNENEAADNNPIVKTTNDVGNKDSPKKKKLKTNAGDEAVTKTQEVKVANNVNGAENASKKSKKKKNKKAQKQENSEESASEKPKLVQNNAEKTEVPEEDGVVANSKRKEKLKQKRKENKELRKEVRKEEGNFSSVNKLSVEEMKKKIAEIEARETQSKTAIRKLRILKKKLSIEEGTIDTTPAQKRKGEAVEDSASGQKNKKFKKDVPIKMEKKEKNKEKINAVQDESKLNKPNKLKKDKQVTEQSLFIEDRVGNKPEKSNKKKSKDSGEEESEVSRAKKILEQVLNEKKQKAKKVKVQNDDDEENSENDEEPKKLAADEDDDDDEVEDKEDDEADEDDEDDEDDEDDEDDEDEDSDEEDTATKINKSKTNVKADKKLKQVSADDEDDDDEVTNEKAEVEEKNKTQQTSVKEKEKKEKPKDFNKQNPNQMNQNAGVPKKQRYVLFVGNLSYDATTVDIKKHFLTKVDIVKDVRIPTKPGTNTPRGFAYVELENSTDYEKALSLHDTFINGRKINVQYTSSGSKHSGNKQEIVHKNKKLHAMRKAGMLAGSKKTFQKRSFRRNSDRNSKTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESN8</accession>
    <name>A0A232ESN8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002393">
        <property type="protein sequence ID" value="OXU21369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESN8"/>
    <dbReference type="OrthoDB" id="10561720at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="234" mass="27054" checksum="99AB3F891FA49B4C" modified="2017-10-25" version="1">MAKTHNCKQKICMCAEVAELTHLYCELKSQRKIATKINNAFANIEFPMNELDVSACGSGLETLRRQRKSVKELMQVLRDTSKELAEDEEEICQTDREIADLQDELRAIEKKSDRRNCCADVTPRKNERIETDDEASWRESTTLEIHERDRLQASISEYISHRTCGSSLHKSYTCQSWERINRMTQCLDILRSKRKSDEAKLQEDRIIDAKLLLDAINYVAKCTTNSALFISNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETA9</accession>
    <name>A0A232ETA9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_016620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002297">
        <property type="protein sequence ID" value="OXU21595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETA9"/>
    <dbReference type="STRING" id="543379.A0A232ETA9"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="339"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU21595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="432" mass="49870" checksum="1DC6EBBA4730690B" modified="2017-10-25" version="1">MASIDNKRVANNTSSNIYGRVPTVGPDKMKVTFCTDMDKSVIVYNFEKRGWTQVSPEDDWNFYWAVTQSCRNIFSVETGYRMADNQTINHFPNHYELTRKDLLVKNIKRYRKDLEREGNPLAERGDGPGKYLHLDFIPVTFVLPADYNMFVEEYRKSPQSTWIMKPCGKSQGAGIFLINKLSKLKKWSREARNPFNPNLTKESYVISRYIDNPLLIGGKKFDLRLYVLITSFRPLKAYLFKLGFCRFCTVKYDTSIQELDNMYVHLTNVSVQKHGDEYNSLHGGKLSVQNLRLYLESTRGKAVTEKLFANISWCIVHSLKAVAPVMANDRHCFECYGYDIIIDNKLKPWLIEVNASPSLTSTTVNDRILKYKLIDNIVSVVLPPDGVPDVRWNKCPSQEAMGNFELLIDEELVAQDERENPGKYRNSSSKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETC0</accession>
    <name>A0A232ETC0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein vav</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_013732</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002290">
        <property type="protein sequence ID" value="OXU21609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETC0"/>
    <dbReference type="STRING" id="543379.A0A232ETC0"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20810">
        <property type="entry name" value="C1_VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21201">
        <property type="entry name" value="CH_VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01223">
        <property type="entry name" value="PH_Vav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037832">
        <property type="entry name" value="PH_Vav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="15">
        <location>
            <begin position="281"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="492"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="608"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="684"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="789"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU21609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="96635" checksum="FE9379EC68A069C5" modified="2017-10-25" version="1">MSGADSRPVVDGNSWQDCASWLIRCGALRADHKANWPTAKAVDLAYILRDGVLLCNLVNSIEKGCIDSKDVNQKPQMAQFLCLRNINVFLTACASVFGLSESDLFEADMLFDLSDFHKVLCTLSLLSNSAQFKSKGIEGFAVKKDGSQDIYKDLQSAGVGSMAPVVTFTIKPRVMDLGESKVYHELLCFSQSTPRHSWSTCSEEENEGRRRRFRRREGAQQSTEDGASVDGAGAEDTVAEEDGYGAFCSQARSEEIYQDLCSLQLTPSQGAAATSTTGGEKRDYVIQELVETERNYSEVLNSLLKHFARPLSALLRPEDSSRIFFGIKDLAEIHAGFHSQLRKAKDGAALGQVFLDWREKFLIYGDYCANLTTAQNTLLDVCANNESINQEVIRCQQEANNGKFKLRDILSVPMQRVLKYHLLLDKLVEETPRDWLEDRRQLLLAREAMVDVAQYINEVKRDSDTLDIIKDIQCSIVDWERAEDIQLKDYGRLLKDGELKVKAHGDQRIKTRYAFIFEQVVLVCKAGRNDQYCYRETIRLDEYRVENPTTRKTLGRDSRWSYQWLLVHNKGYKAYTLYARTDEQKLIWMKSLQDAIDNIAPAACRNTNHKFKLTTFDSARSCERCGKFLKGRIFQGYKCEICRLAVHKQCITYSGRCVPVPPPPPPPPPPPPQPFERELSAKLWYVGEMGRDAAAQKLEARENGTYMVRVRPAAGQPRLKHETNYALSIKADNAVKHIRIFKREVDGADLYYLSESRYFKNVVELVEYYERVSLAENFEKLDQRLLWPFRRVLAKALFDFRGGERNELSLRKGCRVVVLSKEGDAKGWWKGKIGDLVGFFPKEYVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETL6</accession>
    <name>A0A232ETL6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_016955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002263">
        <property type="protein sequence ID" value="OXU21693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETL6"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172528" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="63283" checksum="161D95247E8B37BC" modified="2017-10-25" version="1">MFKTRIYDLIITLIFTWCLMRKACCTFESDELKHLNHMLNRILNESIVYQVAVLFQEQTCAAPTINSMVKSIHVKKAAIVIGATASGYFNRYDNSASQHMLNPRRSTLIFAVFCLGSNDTVSLLDLFKNTIEFIVSLDFRRTRPLCLFVLDAREKCLTDSIKDMFNYAWVRRFLDLTIAQFHSEDAGRLRNLTIHSYNPFTNVYNSDLYSPEMELFPNKLLNMHRYSLAVAIIRRPPAVNFQIDPESDRFLKINDDYVGLVPIFPSPTWHIGYGTVAIMMNVLLHVSLVYGITKILKFCSKFWLPHHILQVLLGNASPKLPTKVTERILFVFLIFLSLYYSAELYANLTDLNLLERDNGPFFTYRDLIKSNLTIEMHPDHTNMTLRDDDYRLYGLEKKVKFVNDTMNCPDRLLENKSVACLIDRAVARAKVLWDSRLHRPSMKLLKPIWSAPKGFIFSEASPYVVEFNRVMRHIFETALWYRWVVHEKKENNTLAARAELLENSDRYLMKKLKIIYFSGCGLAFISFVSELVTAHVNEYLFKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETP2</accession>
    <name>A0A232ETP2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002247">
        <property type="protein sequence ID" value="OXU21730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETP2"/>
    <dbReference type="STRING" id="543379.A0A232ETP2"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032509">
        <property type="term" value="P:endosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000010">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF233">
        <property type="entry name" value="ANNEXIN B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU21730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="342" mass="38444" checksum="74A5D797FC6353C2" modified="2017-10-25" version="1" fragment="single">KKQISQRRAKMSQQQYFPFKCTPTVYPADPFDANADAGVLRKAMKGFGTDEKTIIDVLTKRGIVQRLEIAEAYKTLYGKDLVSDLKSELTGKLEDVIVALMTPLPHYYAKEMHDAISGLGTDEEALVEILCTLSNYGIRSIAAFYENLYGKTLESDVKGDTSGHFKRLLVSLVQANRDENQGVDHAQAVADAQALYEAGEKQWGTDESQFNAILVTRSYQQLRQTFIEYEKVSGHDIEVAIKKEFSGSVEKGLLGIVKCVKSKIGFFAERLYASMHGIGTKDRTLIRIIVSRSEIDLGDIKKAFEERYGKSLESWVAVSILYSVRILFTCITSTVFNFKYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EU01</accession>
    <name>A0A232EU01_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002205">
        <property type="protein sequence ID" value="OXU21814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EU01"/>
    <dbReference type="STRING" id="543379.A0A232EU01"/>
    <dbReference type="OrthoDB" id="44277at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="329" mass="37829" checksum="4FD15E6373D10A69" modified="2017-10-25" version="1">MISVLSGVWNSVEDMIVDYIDFNVTLWLLMPLLITFLLPLVIVLLLYVTALILYVYRLHRHRLRSAYGTDWRNASRSVVAAVWDAHGWIWHGYEVVGIENIPTDEPVLFVYYHGAIPIDLYYFISKVFLFNSKLIHTVGDRFLFKCPGWSIISDVLKVIPGTIQTCSSILKEGNMLAISPGGVYEAQFGDAYYQLMWKKRLGFAKVALDAKVSIVPMFTKNIREAFRSISWGRRLWLRLYAATRFPFIPIYGGFPVKLKTYVGKPIAYDGNLTPEQLQQKVAAALDDLICEHQKIPGSIFWALVERFYDLDKTVECNLKDTEKVKNKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUC3</accession>
    <name>A0A232EUC3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_014268</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002160">
        <property type="protein sequence ID" value="OXU21906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUC3"/>
    <dbReference type="STRING" id="543379.A0A232EUC3"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="151"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="493" mass="55071" checksum="382CE6D3C9571519" modified="2017-10-25" version="1">MKRPVARGEPLTRALGIRYSKAMKRLATVSLLALFCAVLGAAADDGENSIYGMQSLSISADTQRKHDLVLSHDGQPGFDFLRIPRSRGSAIELLVTADKVRSFKEFLQANDIEYQVISDDVSKQIRVELQQQMRARLRRRSGGDSSLDLRAFPRYDEIQAYIIELAKTHSDILKPISIGKSYEGRDIVGVKFTTDDKAFRPTLLIDGGIHAREWIAPTTALYAIKQLAENASNRYIFENIDVYIIPVLNPDGYEYTHLDEKTRLWRKTRSDNPHTICKGADANRNFDIKWMSVGASDLPCSITYAGSRPFSEAESRALRDFILARRDRIKTYLSLHSHGQYLLHPWGFTSDLPKNEPVLRCAAINAASELYKIHGTRYKIGSSTNVLYPAAGGSDDWTMGVAGVDLAYTVELPGGVYGFAPPPSAIIPVGRETFEAIKVFARYVNGEICQGLSSSLKHKTIEFKRENMSNHLTGICGCKIMKDKQWPDAFPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUT6</accession>
    <name>A0A232EUT6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Josephin-2</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Josephin domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_004546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002087">
        <property type="protein sequence ID" value="OXU22122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUT6"/>
    <dbReference type="STRING" id="543379.A0A232EUT6"/>
    <dbReference type="OrthoDB" id="422700at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.40:FF:000003">
        <property type="entry name" value="josephin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040053">
        <property type="entry name" value="JOSD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291">
        <property type="entry name" value="JOSEPHIN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13291:SF0">
        <property type="entry name" value="JOSEPHIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="13">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU22122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="238" mass="27239" checksum="02001D16C49DA0C4" modified="2017-10-25" version="1">MVAGTATGMPGSIYHERQVKELCALHALNNLFQERKFSKQELDQICYNLSPDVWINPHKSLLGLGNYDINVIMAALQIRGCEAVWFDKRRDPDCLCLDNIEGFILNVPHEYKFGFVLLPVKRRHWIALKKINGAFYNLDSKLDSPQLIGKDSDLLTYLKEQMENKEKELFLVVSQEVESRQGWLTESSEKKDSNDKSEESIQHIKETVLDNANTDLNLNNSKENINGNGNILNNQSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUT8</accession>
    <name>A0A232EUT8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_011590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002096">
        <property type="protein sequence ID" value="OXU22096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUT8"/>
    <dbReference type="STRING" id="543379.A0A232EUT8"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU22096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="206" mass="23481" checksum="D1F1550AAC0651A8" modified="2017-10-25" version="1">MDGPGSITWEEFVANAEELLKLSEEISDRWEFPGDKNCPGQAYLKRQEKTLVSIDYPIDEPQEDVDDWTGSRDPFEASSDQKRPLVLEHHVLWSMSYSVPLIYFNGWKSDFPGINPVSVEVAQRLNNQRLGYGELSQAMHPLLARPFLHLHPCGSRELLQLTGKSANPLVSWLSLVAPVALNLRMRPEYFRLTLSAEQKEKDTAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV00</accession>
    <name>A0A232EV00_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002070">
        <property type="protein sequence ID" value="OXU22167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV00"/>
    <dbReference type="OrthoDB" id="7688011at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="394" mass="44935" checksum="9DFBE03D02239927" modified="2017-10-25" version="1">MKLARKLWKITMSRLKEVFIILAFLFVKVEMQKLGKQNFTSEWLVVMKDTLYPPLVTEMKNRLVYVSFPSEFTIKLETSKIVNKPCEVPVTVIKDHKGRNVIPVYAETLGNGKIVVSLLEYKKKPNQSQVWLYVIDPQKCTYVFKKFALDATFLSVRDLMTIVPYNQSFDVFVNSASHCEAGFICSLGFTDELELAEKKKSVIKLDSDGWDITTTKDYDSSEGYLYIVMMNNLNNTIIKRLDSNFDTVQMTHLNYSGSIAYWYDEDGSASSCFGVSDQEIECVLLDAQMQVKVNSSLFYDSYVQYYSIFRLRNGDAVVLTILSSDPDASDSATYVQYLGLDGTIGSPVKFQEYICENVYEMNTFEIKEGLYCSSTMCQNIVNTKCIGAEEIRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVG9</accession>
    <name>A0A232EVG9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001996">
        <property type="protein sequence ID" value="OXU22352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVG9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="418" mass="48720" checksum="E817250AE61DAD48" modified="2017-10-25" version="1">MDENMDKGFEKLTDRPNTSAIETEIFEDVYEEMHASTVKTEILEDDQLDLGLSALKTEASDDAPQEFYFCAVKMDGLEDDELKKQSQYQLEQERLMRKRQRTAERQRRYKARQKMYAEKLEAIVASAQKDCSEFETRENSQTGWANSYLIEQLEKINLKRKKAAERQKRFRESRKQKEEHLQATITTTDENSLTDITHLSAESTVKSKVSANIDYVEDSQIYRAEQELDKLMEKRKKNRESQHRCRRAKKLKEITAYANPSSQSSTDESQNSIEKIGPVDVHQKGSHKILRKVYKKVPVFKKDLSSAQRVTKTGVSTTNVDRLESETQRNLQKDEPQKFYITQIKLGNVCHLKENDVRPDKERFYIKQIKLGNVCNQSKKNVQSEEERENNAKQNLLNFLAAQASNDPNQVLAEQWEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVK2</accession>
    <name>A0A232EVK2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <ecNumber evidence="5">3.5.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptide:N-glycanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_007728</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.</text>
            <dbReference type="EC" id="3.5.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.52" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001988">
        <property type="protein sequence ID" value="OXU22370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVK2"/>
    <dbReference type="STRING" id="543379.A0A232EVK2"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10459">
        <property type="entry name" value="PUB_PNGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1020">
        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038680">
        <property type="entry name" value="PAW_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04721">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51398">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PAW" evidence="14">
        <location>
            <begin position="431"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU22370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="645" mass="74012" checksum="8EC6FEEC93AEFA24" modified="2017-10-25" version="1">MAGNFKHCLTLLQENQEDVKKEAHQILLKLCNNILKHPQDLKYRKIKIDNPVVSSKLLPAAGAIECLFEAGFVENDDEFFLPLNASLTGVRDLYGLLNSSQRVTATKPASVASTSTQKPTTLVEKPLVEEKEYKRKSFIEQLIRHFHDILRYEDQALQNKVKSILPLEKLQITAMEKLRTIQREMKIKKSQDDVVIEDLLLSELLNWFKNKFFKWVNSPACKICTGDCSYDRSIVSTNPDISRIEIHKCKICGSETEFARYINPETLLYTRKGRCGEWANCFTLICRTVGFDARLVYDKTDHVWTEVWSVAHNRWIHADACENVMDRPLMYEKGWGKKLSYVIAFSRDEIQDVTWRYTRKFEEVMKHRNVCSEKSLMLLINKLNLQRQNSRGYSQARKKFVTKRYVEELAQMLNAPPGCKKPCETSENESDYGGRTSGSLAWRISRNETGDTSYTATQWNIPRDVVNFELTYSILNDTYVTKDTSNSKNLETRQKWQTGVAFVEGGIFTKKEEDWKMIYLAKSPGSIFGKITWAFVVEDNENMYINSVKLQAKTATFHGGSVKWQVEGIYSNENTKGESKVVSILESENFETKDLKGAIKINVTAVLSGGEGESAWQHAQLFRQSLDANSNDLSMVIRIDLEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVL4</accession>
    <name>A0A232EVL4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tesmin/TSO1-like CXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001977">
        <property type="protein sequence ID" value="OXU22397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVL4"/>
    <dbReference type="STRING" id="543379.A0A232EVL4"/>
    <dbReference type="OrthoDB" id="7699256at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF1">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1143" mass="131015" checksum="359B4815D4F5A1F3" modified="2017-10-25" version="1" fragment="single">VSILLKQKHGPDYTVQHKVIKKCLIKYFGEKISFVYPNQKNVSQLFHSSNITNTIDYSYNRDIIVECADVLKDSLKEVSFDLNDRFCDENDLRSAWQNVDIPKPFLTFFSRLFNVKENDICNYQTYANQNCQSNVPIPSHFDRNSYVTAAFDNFDHIENSISGLNSTHDTVAVIFQDYNADFDCRKPKVSTTKLHCNARAFTTKLKCQEVLNYTKLSNTVTLPADFAYHNNHQSFSIEQLENDLQKNDFIWYLSRMNISSDDQEIGIRNTNQHFPTWSSFNSAILKDCRPKQIVGFLPILPAPVTEFSTVYTSLCNFKDILNQLNQKQLAVVCDEGVYKLARHITLTNNKEFENIIVLLGNFHMIKVVLSCIGKYLKHSGAETIFIEASLFGVSVTDQVLSGTHYARSVKGFNYLAESLRRLQIKEFFTSERKIKYENLLVSIVLLKESFQEGNLDECSFVVNNFQENCSELLDDFHTFVLSRCEESELFRNAGVIGITKKKESVTAWNLTYHELAAISDVLKTITLSNEENVELDIHHEFTEQTAAKSEDAITSILNFLEDRNINPFTSGSQKLQNLITGELVHPDSTKEILNIFITGTELYDKFKKERIIDKAKPLSALIPRCNLPSFKTIPVTEKSNTEKKKNKKNGGIHRIFALAAERKYPIDKLLTYDLTYDNKLFDDDGMMKKENNKSSLVRELEKVLKNDEYSCTKTENSTCVIIDVMLVMRKIGWKGKNTFVDLAISFCQYVKSKVDVNSTTRIDFIFDSYFPNSLKSSERLRRRQPNCITYSDINEKTALPKEESKFWGSSENKMLLQSFLRQYVENYNYIFEGIEIIFSTTNTEPSSCINSDKDDSFWQSLQRNDVEEADEKIMLHINHAVMNGFRNIYVISSDTDVIILALYYWTIFKTNGLQALWFQAGSSNTIRDIPIHTLACVHGEKLCSVLPAVHHLTGSDYTSKVGTKSSALQGDPEKYLLGFGQDDSEKNFEKYLQAAEQYLVKVYKKNSNCNTFNELRVWSYHHATCDSTENLPPTSATMRLHILRAFYIVNLQTKCLLEKNSPLNVLAFGFKKENDLLIPEIVTILLPPINDLVPSCNCKVCSRKTCCCVAAEIECCSFCFCHRDKTCQNKYNITSIDTLEQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVS1</accession>
    <name>A0A232EVS1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001961">
        <property type="protein sequence ID" value="OXU22444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVS1"/>
    <dbReference type="STRING" id="543379.A0A232EVS1"/>
    <dbReference type="OrthoDB" id="9899341at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052835">
        <property type="entry name" value="Nepro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027951">
        <property type="entry name" value="Nepro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34761">
        <property type="entry name" value="NUCLEOLUS AND NEURAL PROGENITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34761:SF1">
        <property type="entry name" value="NUCLEOLUS AND NEURAL PROGENITOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14780">
        <property type="entry name" value="NEPRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolus and neural progenitor protein-like N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="385" mass="45174" checksum="1F6CBFFEEF61D2E1" modified="2017-10-25" version="1">MEILWNQINLQRPPYRSWDVSVTEFDSKRFIDSIDKILSDFKTFQVLHAEAALLSRLIYRMKSKFRSDKGLKHMEKVNRALLNYLNMAMEREYELLKEYIEINNGIISLPPRQTLEYVLVRTQGFAKLMCRVESTASIAGNFLKSRLCIGQSWTVAMIAYAVISRIWILSRHVIKKSCNWYNSIFDHMKNFKTVGISWLPDNYILPENLAEWLDLPWFNEDMEKLPIKENWDKSIFSLMKANDADEEDLNIANDTIPKNLTAISEDVNCQNDMDSVQMDMDLGQPISRLAFEETNQEEKRKKPVKVKKKKRNPKKFEKLLQVESEADLVTLLKIDSFPGLDKLQLNILQKQIKKLLLKLTEKNTRNLDEEMLKKIRKGIKKWTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW98</accession>
    <name>A0A232EW98_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_001130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001889">
        <property type="protein sequence ID" value="OXU22630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW98"/>
    <dbReference type="STRING" id="543379.A0A232EW98"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000443">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="89"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU22630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="515" mass="58174" checksum="45D8C3B39DCEDA5B" modified="2017-10-25" version="1">MSDDEEVQYTRRPRTVHYGSLEESERNRINSGINNDSNNDDSSMPSALIGNVHTSNEYMELEDDMSKDRQALLEEFERRNKARKINVSTDDSEVKKNLRHLGEPICLFGEGPADRRNRLKELLASLGEDAIKKKEEDDKSAQPEKDPETTWYHEGPDSLRIARLWNTAYSLKRAKRRLEAARKELETPGATRTAKRQELLKKVQALTIHHSQVGDNRPLSYCQFSPNSKILATASWSGLCYLWSVPDCKLLRTLKGHSCNVGCIVFHPKATITEDIFEERVSNTCILASCASDGSVKLWGGGKGENTLAEVEGHTERVSRLAFHPSGRFLGTCCYDSSWRLWDLEQQVEVLHQEGHTRPVHCISFQVDGSVVATGGQDSFGRVWDLRTGRCVMFMEGHLKSIFGIDFSPNGYHIATGSEDNSCRIWDLRKRSCIYTIPAHMNLIADVRYQKEEGQYLVTASYDGTAKIWSSNAWQPLKTLPGHDGKVMSVDVSSDNKFIATSSYDRTFKLWAPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX19</accession>
    <name>A0A232EX19_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPN-loop GTPase</fullName>
            <ecNumber evidence="9">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_012847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01001793">
        <property type="protein sequence ID" value="OXU22906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX19"/>
    <dbReference type="STRING" id="543379.A0A232EX19"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="378" mass="42466" checksum="5DA6ABC80FC248BF" modified="2017-10-25" version="1">MAEAQTSNKPADDSKPSSEGKQGEEKKPTCIIVLGMAGSGKTTFVSKLVSELYDTGKPYVINLDPACNEVPYPANIDVRDTVNYKEVMKQYKLGPNGGIVTALNLFSTKFDQVIELVKQAGKNHEYVVIDTPGQIEVFTWSASGSIITEALAYHFPTIIVYVMDTVRSVKPVTFMSNMLYACSILYKTNKLPLVVVMNKIDVVDHSYALEWMQDFEAFQEVLDNETTYISNLTRSMALALDEFYNKLHICGVSSTEGTGIADFLQLIEEAKKEYFKKYRVRWQKNRDKHLKLQQEKKEKQLLDAAKATAGENVPLITTVSSGREIADIYLKHPGNESSEDEEGTEEGPKVDEDEHKEAESFANFLEKHKTEQDKRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXS2</accession>
    <name>A0A232EXS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Termicin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001738">
        <property type="protein sequence ID" value="OXU23069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXS2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012534005" description="Termicin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7318" checksum="C3613CB5B8A21742" modified="2017-10-25" version="1">MKFLLCILLLFVVYAVAHHELAGGECNIVTCTEFCTTKIDSTKKYGICVEENKCHCMDSAENSKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXX5</accession>
    <name>A0A232EXX5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001720">
        <property type="protein sequence ID" value="OXU23129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXX5"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759821" evidence="4">
        <location>
            <begin position="24"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU23129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1017" mass="116431" checksum="EF2E85C61F1FBC11" modified="2017-10-25" version="1">MFDLKSGFIVSVVLACSVLISDAIEFQIYNLAQSWPQTSCWDLNNLWAEAATTECSKCQMSKDKQSFTIHGLWPSNKNKRSPENCGTEQLNAQSLNSQKAKKSNVKFWAYEWIKHGTCSQFSVPEYFGKSVELLDKNNAGQVLASAGIVPGNKYPYSQVVNALEDRLKVNVRIKCATNSATQEEYINEVNICYDKSFQLTNCKNSGSTTNCKKPTLQYPANLKTCPQSDVTDFDVLTLSQSWPQTSCWDLNKLWTEAATAKCSSCQMPKDKQSWTIHGLWPSKLQGKHPAFCSTKPKFNAKLFNDELREQLEEKWPSYNLKMTYEAFWGYEWKKHGTCALGVPSTSTIPKYFNKSMQLLDSYNVGKMLASSGIVPGKKYHYKDVISVLENMLNVNVYVKCAVNSVTKEQYLNEISICFDKSFKLTNCNIGGSTTNCKSKDVEYPANFIPVSIINNMFKCVLFCVIACASLSFADNYNRRLNNPSGPQHKSFDVFTLAQSWPIAACWDLNSKWSHMNSPCSPCRRTASKNWTLHGLWPSNLHGRHPAHCAGRKNYASAQMDINLRSELQRKWPTYKLSMSDDSFWNYEWKKHGTCASGHASTNSLKKYFNTALELLDEYNMGRIFEEANIHPGHDYEYSRIVQAFSNALGVNGFFSCRKPSGSSDRHYDEKFDYFLLTLSWPQTTCWAINKNWQNTTCNPCKRLSDSWTLHGLWPNNYNGKHPFNCEFHEKFDPNLLSQDLKNQLNDQWPTYKLNFSNKKFWNHEWLKHGTCASKLKATNTPEKYFSKALNLLDEINMTTLLEKVNIQPGNQYDYYTLVDAISDGLGVKAQIGCRKNPGTIGQYLYEAYICFDKSFKLVDCHNLQSCKRKGKIIYPKSFKSCHIKNSICASTAVEHNIWTLYGLWPDNYNGTYPSDCENEMQLEPSSVNQTLIDQLNSKWPTYKLTYSSQFFWNYEWQKRGNCATEINETNTLEKYFSNSLDLLDKYNMGKILRKANVQQGGQYENSTILNAISDKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY18</accession>
    <name>A0A232EY18_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001660">
        <property type="protein sequence ID" value="OXU23291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY18"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="539" mass="63024" checksum="649C67CB8BE40792" modified="2017-10-25" version="1">MSEITDASILRDVIQRNGLRFSNFKTRDASKLYSVQAFLNKVLDLKVNIVNTESIEELQPCLDQLNREFQKRSYPEYDLAKEGIQELLIDETDDANVLNVKSKDGIDIDYKMATVVLKSYLDNIKTRLEIFKYVCVHIADRDIGTQTGIFPDLGAVTWNLSKNLDELRADRFRKKIIAIHLESNILEIKKSEDIIHAASEIDSLIIFSTFVKQPNLKTERLSDYAPTLASLKFKDDDKIQKYVMPDKKVHYDFKRQITLVKPQNQTQRKALYKIINSDELMVKYSRPILNENDSVTSFYRQLYNSDLIYWEDYKIGFLTESIKNRYIEFYKTMVIDSNSEFDIESRFLRHANDFLNFKEKENGNDTMESYAYYFLKSLDLFITKWAEINQPDYEATLSLELYHLLRQISSNGVKSNVSVNNSQGTTKLCDLMFRNKETALIIKAKYSRNKELLMQGLSQLENEYKTVLKEYEKQAYLVIDMLHQEKNKFMVSMILQVAYSNDGANESTKPRISFLTLYNTIGDKTCIHFDQKYKLLELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY55</accession>
    <name>A0A232EY55_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001644">
        <property type="protein sequence ID" value="OXU23332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY55"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="48" mass="5726" checksum="E5DFF754F05F0D30" modified="2017-10-25" version="1" fragment="single">GPPNFISEELHYQEEQQSKEDAYNEEQDDINVNDDSYENQENSENENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYA6</accession>
    <name>A0A232EYA6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001651">
        <property type="protein sequence ID" value="OXU23315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYA6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="33" mass="3976" checksum="32D59E87DDA4359B" modified="2017-10-25" version="1">MTRMLNKRKAMSPSQVEEQQENYAKRKINKLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYW1</accession>
    <name>A0A232EYW1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_008884</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001573">
        <property type="protein sequence ID" value="OXU23551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYW1"/>
    <dbReference type="STRING" id="543379.A0A232EYW1"/>
    <dbReference type="OrthoDB" id="252722at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
        <property type="entry name" value="RING-HC_PML_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026642">
        <property type="entry name" value="Glcci1/FAM117"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972">
        <property type="entry name" value="AGAP011572-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972:SF8">
        <property type="entry name" value="GLUCOCORTICOID-INDUCED TRANSCRIPT 1 PROTEIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15388">
        <property type="entry name" value="FAM117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="8">
        <location>
            <begin position="364"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="9">
        <location>
            <begin position="472"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="9">
        <location>
            <begin position="559"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="953"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="964"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1089"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU23551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122168" checksum="D1252F17491CCD06" modified="2017-10-25" version="1">MEALRLAIQCGGGSGLFLEEALIIAQLTVGMQMFTFQNATRLGERMVSMSSMLVETVSINYEDFNESFLTCGTCLCVYDGSEHTPKLLPCSHTVCLHCLTRIAASQTREAGAFRCPICRELITIPRGGVPALPPSFLVNQLLDLMSRQRREVIPKCSVHINQELLFCETCDTVFCTVCTGGNHAGALPGCTEHTIIPFSIAIKRMSEILLYKANECISKLTQAQDSVSTELQRLDSAKQKCLEAVDAEFANIIAKVERRKTELHAAVNAAARDKKHVLEEQHALIEAEKNKVERECEGLQYQVEVRNITQRIGSLSDQLDAAVALSEPRENAFITSEFNHNDALANLEQALKAFGRVRSSTTLPSLCRAKLKDTAIVKLQTTVLVETVDYHGHPRNAGGDPIGAELGLSDESESQNQNSSVTTEVKDLENGTYEVIFRPKVAGRYALRISVFERPIKDYPLFFDVTEHNEPIKVYGHRGSGKDDFHQPVAVAVDDNGIIYIVDTGNSRIKVLDDNLEFMRHLTNEGLEGRSCTGIAISEQGLVVVNWRTKSVTEMTTLGDTIRSFSHNAFQEPIDVAVDRSYGHVLVADNGQCCVFVFDCDGKILFQVGKKNMFKLIVSVAVGPAGEILVVGSRIQVFSAKGDFTEEINAESKDKGRYGGMAIDSEGRILASRTEKGRTVIQVLKLGGGAILSEIDSHSSKLRRPSGIAVLPNEHLIVVDLGNDCSEFMERSYFAAKSKTLSGRCSDSLSGSQNIRRTASLDTIYLKGQWPRDSHYIHTILRVDKATQTDECSNEPRKTHSRHPTEQTMTDEKLEKYFRHRLQRTNKEGTSSRERTAAFGLIMPGGPPPALPGDHSVLLPSIASQTSTHNQFSLSTKASPMNIPVKPIRPPMRSSIEGLNQEIEGLVLKSTGNSSDLDYQIEDKYARYRDQITPEGHRAPLADLFRANRSVNSVNTQTPATDLPSSSYSSGPPSRNSESPLIPGSMDVSRPSSDLLQVYIWLLADICGSRGSTPEQEREGRLGTSPHINRFLAREPPDGCEKVNTKFVEDVRRPMADLSKLDYCSKPCVAFQLKPSLGSAFLPLQQPVSPTMATSATPSSHTTPTTPPPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZB8</accession>
    <name>A0A232EZB8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001532">
        <property type="protein sequence ID" value="OXU23669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZB8"/>
    <dbReference type="OrthoDB" id="6093252at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="13050" checksum="B042E0168E6C8AFD" modified="2017-10-25" version="1">MFLRWCPATSSFSEALRSLLEIHKSIVVFRQFDKIQSIIQRSKMFALSRTVAPRIASATAQQTRNYNIVAKPRVRVSFAEKVIHGIFLGSIPLICPLYLSCKFGQWTQEQMDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZF1</accession>
    <name>A0A232EZF1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPPC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001524">
        <property type="protein sequence ID" value="OXU23699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZF1"/>
    <dbReference type="STRING" id="543379.A0A232EZF1"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055428">
        <property type="entry name" value="TRAPPC13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23643">
        <property type="entry name" value="TRAPPC13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="4">
        <location>
            <begin position="173"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 C-terminal" evidence="3">
        <location>
            <begin position="306"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU23699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44871" checksum="33D0BDDB4437EB42" modified="2017-10-25" version="1">MESKPKSEHLLALKVMRLTRPTLASPVVVTCDSTDLPGNTLNVELKNDCTALQGMETVAIGQFMILPQSFGNIYLGEIFSSYLCVHNGSHQAVKDVTVKANLQTSTQTIPLSGQNSQATELAPNHTIDEVIHHEVKETGTHILVCEVTYTPLLLGSQPLSFRKFFKFQVVKPLDVKTKFYNAENDEVYIEAQIQNLTAGPICLEKVALESSHLFTVSTLSANDKQESIYGKLNLLDSGHSRQYLYCLKPTPSLAKDPKMMHNATNIGKLDIVWRSNLGERGRLQTSQLQRMAPDYGDLRVSAKDIPSKIYIEEPVNFKIHIINTSERQMDLLLGLQSNTSVAWSGISDKMIGTLKPGESVHLPLCLIPLESGLVAVSGLKLTDTFLKRVYDYDDLAQIFVNHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZM4</accession>
    <name>A0A232EZM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001444">
        <property type="protein sequence ID" value="OXU23956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZM4"/>
    <dbReference type="OrthoDB" id="7685774at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="377" mass="44349" checksum="03541CFEB675AA15" modified="2017-10-25" version="1">MQTGFKKDYPSNVARSGSILTSGRVGRVPRFEYVNRQGQVVNPKTGKPYDRKHENGVHHQSSGKSAAKALNKRYPIKTRGTMFGGLEPIPTDPTRDPPPRVCYNCWQKGHSRRDCPRPAVARYCNNCGRRGEDLRTCPRCKLAHDRYLIQLQAKERGEELDPEEVERLLPESEFYEDEIEQDEDGCDEILRELMLQDERARIVSNGLNRDYQERRIGLAVFQEREDAFPFKNREREMEIEREEDALKNLYAERGRQERRSGYSDRETRYDNEIDQQYEMERRERNEREERERERSRWRVQEVMSNAATAKQSTSSTTVSEAQITSDPVQDFLLLAKTIAHLSPETQDLIMRQVIAERKEHQARWKGMQQEHEEDTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F035</accession>
    <name>A0A232F035_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001451">
        <property type="protein sequence ID" value="OXU23939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F035"/>
    <dbReference type="STRING" id="543379.A0A232F035"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="302"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="756" mass="85131" checksum="FD3371D887C1718B" modified="2017-10-25" version="1">MLSVAQAVHHPETPGSASKHSSLGHSWSSDRSSMLKRRKTESECCIVDKKPLTTSSIESITKQFHFNDQEITLTAIPKNHNQMHAKSIGVIQGSSNDESSQDDTVNEQISSNGAMSFLSNSGEVQLIKLNCSDNKKIQSNESVDDAHNNLETPAIESKQNAITLNPIAELSEVTIEPCQKSKKTSSRLAEAQEFLKQKETPVHVSFATFSTNETLDNNSNTTTTPTEIQPFVPECNKAEFEELFGGDFDKPIFSDSPKSPSGNGNLEHQMPVPTVSDYEPFHVGVSCDCFYASNRDRPYYATGFPNPPTENRCWINSTLQVLFSLPIMDDLYSIDSIQDSKLMSSLLSVYSYWGRSSTGSRIFDHTFNTFKEELSRLDNMYPSKAQQDVSEFIMNLLNFIKSEFDSILKKETQHTEIENIPNNEQDTPRRLQQNAVTDSNKRLPLVDISTLTATTTTMQLRSNHQLNSKANSSAMKSKSESQIRSNLIDEYFSLDMVENLVCNGCSKTRQQKVENLMLFVDLPSDDHGATLNLVEMINTTYGTEQRDIKCETCQHDTHSMITKLKRPPKILTIQLKRYEIVYGLLTKKCSLVDIPMLMRLDTLVINCEDFTHTIVYEPICIISHIGDSIDSGHYISFVKHNDQWFYYDDINVRLTSNAVNKIKEILKDKPEYIGLKVGVRQRGCNGLSYTLDYATDKSKLDEEVVQDGVRVIIDRKAQLSLLGTEMDYIENKLSSEFVFNNPNIKGTCGCGESFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F038</accession>
    <name>A0A232F038_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_001442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001435">
        <property type="protein sequence ID" value="OXU23982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F038"/>
    <dbReference type="STRING" id="543379.A0A232F038"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU23982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="315" mass="34805" checksum="13F7EC49687163BF" modified="2017-10-25" version="1">MQSTGGWQFGFGGSAGIKDSSNSTKSTGRLIRVILLGQPGVGKTACIKLEEVCRAIARIKVRTRYIKLNELRKTISRAIAVRFASRRFIGEYDCSIERVYRVGSQDSIVAYDNSHQRILPATSWEIADPPGNPAKAPSESRLRWADAILLVYSVTDRVSFDETWRLRFLLNQARKSSKKLAAPVVLLVGNKTDLGGPPDGDRMVSTAEGRKRARDIEAHGFHEISARESYEQVMAVFVSVARLVLLLPASSSEEMQQQQQQQQHHQLAAGGGAYSSSSFRLRASTDGSIDARRRQTVLQPLSKRRLSISARGAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0F6</accession>
    <name>A0A232F0F6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="9">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_007771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01001391">
        <property type="protein sequence ID" value="OXU24141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0F6"/>
    <dbReference type="STRING" id="543379.A0A232F0F6"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06617">
        <property type="entry name" value="PKc_MKK3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000126">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF11">
        <property type="entry name" value="LICORNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU24141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="338" mass="38352" checksum="016E82FA14DFC282" modified="2017-10-25" version="1">MAFNNRRKGVGLKIQVSEEAPLPVTPPRNLDKRTTITIGDKTFEVDADDLEMLCTLGRGAYGVVDKMKHKQSDTIMAVKRITATVNTQEQKRLLMDLDISMRCSDCPYTVQFYGALFREGDVWICMEVMDMSLDKFYTKVYKHNRSIPEEILGKIAFAVVSALHYLYSQLRVIHRDVKPSNILINRKGEVKICDFGISGYLVDSVAKTIDAGCKPYMAPERIDPTGNPSHYDIRSDVWSLGISLLELATGKFPYESWGTPFEQLKQVVKDEAPKLPPNRFTPEFEEFTNKCLMKNYTARPNYNQLLELSFIKEHATKDTNVAGFVEEVLDLPDAEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0Q6</accession>
    <name>A0A232F0Q6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001391">
        <property type="protein sequence ID" value="OXU24139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0Q6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="10252" checksum="24022630DE6B7334" modified="2017-10-25" version="1">MYSSIFELIQCDMILSLTLSPRGPGQFGCFYRIALHYVHTKETCRDSFGRTLANQIFFYNMDNTLFTLIFFPMREKYCNFHRTLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F138</accession>
    <name>A0A232F138_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_010596</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001282">
        <property type="protein sequence ID" value="OXU24496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F138"/>
    <dbReference type="STRING" id="543379.A0A232F138"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18078">
        <property type="entry name" value="DEXXQc_Mov10L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase MOV-10 helical" evidence="15">
        <location>
            <begin position="561"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="14">
        <location>
            <begin position="627"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="12">
        <location>
            <begin position="802"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="12">
        <location>
            <begin position="928"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="13">
        <location>
            <begin position="1041"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU24496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1265" mass="144643" checksum="FDBB442E687144BA" modified="2017-10-25" version="1">MQESQSSKSSSTEKFLNKIKSDILIKKNQKQESKELHTKRYVSNKIFGDTINNNDGNRNEEPEEESIESLLAQIEDIKQTSEQNETPQLSFNNSEEKGCFHKTGVVTLVTDNYVLIENDYMCEMKYVVPQDLKKGDKVYYMAYRANENGDLKIRKIEYKFDAVWEQDEIEPLKYSEPMPNIELELDKPVESFDIDPPKPHIENQPVTKSSRINKYCVLTGGSSDKIVKKRDINKRTYTDKVVRRNGREVFFENYTDISVNLDNISSEFVPMIGDWVKIECLVEVNEEIPNFQGEILQVESILPNRSFNKLGKITHYDNQTEVGRIEETIIFTKAVCSDGYIPCVGDKVVAQSIESDQGLQQRWRAMKVVPLEDVSNRFETETVKFKPQLPDDEKEELLKDKENIEITNNLTLTLNAKEEEEIDIVIKNNGNVRQTLFKCAFLSRRSNSQLQLVSPKENEQQFVVPGSALTYKFKCRAKIVGVSEEMVIFKFRKFKIARIVQITVNSINPKKDNSNEGSTNTYNRHCNQYSIIPRVYEEGMYIRGVKPYKVAKFIPVRPVTWKIPDVLWTVINKIKIEQKTHSEAVFALVEAVPCLHEPLSIRNYKKRFDYLLYLEEIEQTINMQKFDMKSATLHRSGEYLTLNVPGLAENRPSLILGDRVIVSFLWDSTGGEKKYEGYIHKIRSSDVFLQFHQSFHESYHGEDCQISFKGSTTVIQRCHTAISTVVNRLGQDFLFPKKVKQQEPQYNFVEEEEASDGDNKDDSDQLTTDPPMLDDLTSHEEKVKILEDLLSRRKLKWFNKRLNKYQKEAVKNVLKGLARPLPYVIFGPPGTGKTITVCEAILQILFTMSESRILIATPSNSSANLIAERLLDSNLLKPGDLIRLVAHHYLQSESIPEKLIPYCVTADIASEGSRGDVNHIDPRGCKTNVTLSVLCQHRMIIGTCSALGILYNMGCKSDHFTHVIIDEAGQACEPEIMIPLSLAHSSTTQVILAGDPKQLGPVNQSRLAGYYGLNDSFLVRLLQQFPYQRDPEGFEFGYDPRLVTKLLINYRSLPDLLDLPNKLFYEAELIPQVDPENSDEAKLLESLADMLPKRLGTPPAIIFHNVDGTNVQEPDSPSWHNPEEATQIYIYLLELYNRGLEPDDIGIITPYSKQVYNVRNLLAAFEMDIPKVGSVEEFQGQERKVIILSTVRTAPDKVREDITHALGFVSARERLNVAITRARSLLIIIGNAKLLYQDVYWRSVLDHCLNKNSCVNLTLEKQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1I2</accession>
    <name>A0A232F1I2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="15">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_012891</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01001310">
        <property type="protein sequence ID" value="OXU24402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1I2"/>
    <dbReference type="STRING" id="543379.A0A232F1I2"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="17">
        <location>
            <begin position="441"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="18">
        <location>
            <begin position="611"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU24402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="708" mass="79251" checksum="C2EBAD9F5DAAC54D" modified="2017-10-25" version="1">MRERESTTGMSSRKDNGADSSGSASCSKDAGSEREACIPELLLTGLIVSLALLLRWCISYHPYSGAGKPPMFGDYEAQRHWQEITLNLPVSQWYSNSSDNDLQYWGLDYPPITAYHSLLLARVANLVDPDSVKLHQSRGYESNTHKYFMRLSVLVVDFLLFIPAVIYFAFAILPILDSKIKKQQDKNEKRDFSMLKKRHFVLATVLFYPGLILIDYGHFQYNCVSLGLFIASVSALFQGAMATGSFFFVLALNYKQMELYHALPCFFYILGINTPGKRKPLLVCLRSLICVSLTVIVTFALIWAPFLTDRKVFMDTVLRLFPLTRAPGKVILFGEHSVVYGKTAVAASLGLRSSLHFTELPHEECIIHVKMPKLGISKIYSLHQVKEDFLRLDFYTINHDVISQKLRKYVAKLGFENPDQRLSMQCFFYAIVQAIIYDDLRLSSFILELDSELSIGAGAGSSASFSVCLVACFLYWSQLQKHTNLPNEFDSASLDKISDYALNCEKIMHGKPSGIDNSVCTFGSVIEFRKPEPPKFITLGSKSLRVLLVDTKVARSTKLLVEKFGALSSSFPTIFKDMLQVYDELAMQALDIIKKIHDTPENDQDRLLKHYDELSLLVDINQGLLATCQVSHETLDTICKTAKKHGFSAKLTGAGGGGFAYVLIPPNVNNEKVEDLTNELKIQGFSVTETKLGGSGVEVNDMNDDDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2I3</accession>
    <name>A0A232F2I3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OCIA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_008379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001211">
        <property type="protein sequence ID" value="OXU24719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2I3"/>
    <dbReference type="STRING" id="543379.A0A232F2I3"/>
    <dbReference type="OrthoDB" id="6513616at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040187">
        <property type="entry name" value="OCAD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009764">
        <property type="entry name" value="OCIA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336:SF3">
        <property type="entry name" value="OCIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336">
        <property type="entry name" value="OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07051">
        <property type="entry name" value="OCIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="OCIA" evidence="3">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="251" mass="28309" checksum="2017E5E4AE089589" modified="2017-10-25" version="1">MSYYPADVPQGSPQERYQSQSFKLTPEEQRILNECSKEGIFQRAIPMGVAFGLGGLMAARAGPLMSKRFGVKPAVLGFGILGYMIGRFSYGKICIRRCLEVPDGNLKKLLPHLQQQGGYIDPTPDAFYLPVEVPKNQDPVRQAQSQNSDIDIPTMSNWDTIPSEYYEKNAEKPQDDMAATNYTSYDDLRKQNRIEYSQKYYGDMTSKQSRYPNQPQDGPVVRRPTPQEMQPTSPTGTIGGRQTKYGDIWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2J4</accession>
    <name>A0A232F2J4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001125">
        <property type="protein sequence ID" value="OXU25046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2J4"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08889">
        <property type="entry name" value="SRPBCC_PITPNM1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000173">
        <property type="entry name" value="Membrane-associated phosphatidylinositol transfer protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000001">
        <property type="entry name" value="Phosphatidylinositol transfer protein membrane associated 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF81">
        <property type="entry name" value="PROTEIN RETINAL DEGENERATION B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24694">
        <property type="entry name" value="LNS2_PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24695">
        <property type="entry name" value="PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="7">
        <location>
            <begin position="705"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU25046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1318" mass="146438" checksum="AD88658D6BA900D8" modified="2017-10-25" version="1">MLIKEYRIPLPLTVEEYRIAQLYMIAKKSREESKGAGSGVEIIVNEPYTNGPGGDGQYTHKIYHVGSHLPGWFKSLLPKSALMVKEEAWNAYPYTKTRYTCPFVEKFSVEIETYYFPDNGFQENVFKLSGSDLRNRVVDVIDIVKDQLTGADYIKEEDPVLYVSEKTGRGPLSENWLDEYWADVKGKSQPTPSGKSLMCAYKLCRVEFRYWGMQTKLEKFIQDIALRKTMVRAHRQAWAWQDEWDGLTMEDIREIERQTQLALQAKMGPAESGEDLAEGEEQDEDKVNATITPQDSGQVAMTLAATLGSIEKNEDPQSPASPRKPSDIPIINTGVSSGENSPEDSPTEVLPPRKTEKVSKAEKDKTWKKSSSSLHSPSSAKSFDAQIANWRMESIVRESESGSDDEFFDCQENFELQDNSSLAKWSSLDLLAEEEDSTSPTVTDFNKQDDTIFSHSYLQRVASERSGKRLAIRTSASIDVSCPASPQHSPTHQPCSTTVLLIVMHAGSVLDANVDLTAKKSDITTFKGAFESVIRQHYPTMVGHIAIKFVSCPSICTEGLGILSSLSPYSFDVSPSCMDTPQITHDTIPIGAIPMLATSTPDYQDAVTRVVNGANQVYQEFVKSEEGRGFNGQVCFIGDSVGSILAYDALCRSAQYQSRHDSENSILDNDNHENSGPYEDGRHLSAPSPRRRSSSTSDNSHQCKLEFEVSEFFMFGSPLSLVLAYRKISSTGEKSSNISKPCVHQVYNLFHPSDPVAARLEPLISARFSLLPPVNVARYQKYPLGNGQPYHLLETVQTNPQLFADGLNVPNMTMSHLRRLSDISIHSTMSGIETVPLQAVSSLSQKWWGTKRIDYALYCPEGLANFPTHALPHLFHASYWESSDVIAFIVRQLGRFDPRLLGNEEKELTDFRPGQPREKWNKKRTSVKLKNSAATHRANDVIVRDGAPQILVARFAYGLCGVISLTGEKVDIHIMKDVKSGEWVFYSTEVTDKTGRITYQIPDDRTLGYGLYPVKMIVRGDHTSVDFFMAVIPPKTECVVFSIDGSFTASVSVTGKDPKVRAGAVDIVRHWQELGYLIIYITGRPHMQQHRVVSWLSQHNFPHGLVSFADGISTDPLAHKAAYLKNLVQEHGVIIHHAYGSNKDISVYTSINLQPNQIFIVGKVSRKNHALATVLQEGYAAHLTILQAHGGSRPAQGNARMVIPRGQFGLPGQNASLRRRSNDTAVNSPARSSVYLKGKSTLVGEARHIAASREQAVKSAGAKCERRTIGFAESVSAAATLVSGWQVQRTRQVMTIRPLSLVVRATAVEFIKDDPVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3B9</accession>
    <name>A0A232F3B9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="9">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_002639</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01001148">
        <property type="protein sequence ID" value="OXU24980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3B9"/>
    <dbReference type="STRING" id="543379.A0A232F3B9"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="85"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="509" mass="56044" checksum="D4866AA9D8173867" modified="2017-10-25" version="1">MMQAARRAAQTVGSRTKWLSLSGSRLASQKTQPELTAVRYKVERGPYAVIGDAHASFFNGLLGPERVITEPDECDSYNIDWLRIVKGSSRLVLKPKSTEEVSAILRYCNEQRLAVCPQSGNTGLVGGSVPVFDEVVISMRLMNQIISTDELAGVLVCEAGCVLQSLEEHLNRVGMMMPIDLGAKGSCLIGGNVSTNAGGLRLLRYGNLHGNVLGLEAVTANGNVIDCMNTLKKDNTGYHLKHLFIGSEGTLGVVTKVALQCPSLPKAINVAFLGMKNFESVLEIYRLAKSELGEILSSCELIDRISVENSKSALGLRSPLSDEHNFYVLIETAGSHLAHDEEKLEAFLTKLMDGGIIDDGTVTSEPSKIKSIWELRERLAESQTKEGYLFKYDISLSLPHFYSLVPVLRERLRDYNVRFVTGFGHLGDGNVHVQVSTPDFDEEVNAKLEPFIFEYTAKLHGSISAEHGIGFKKAKYLHYSKDQSAIDLMKLMKRTMDPKGILNPYKVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3I3</accession>
    <name>A0A232F3I3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001128">
        <property type="protein sequence ID" value="OXU25040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3I3"/>
    <dbReference type="STRING" id="543379.A0A232F3I3"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011968989" description="Glutathione peroxidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="207" mass="23427" checksum="4812BE9EB2AE63F6" modified="2017-10-25" version="1">MMRFTVILGLVCIAGVFGQSCDKTKEECPDAKEAEVKFNQDTDWSKAKSIYEFHAKDIRGNDVSLDKYRGHVAIIVNVASQCGLTDTNYKQLQSLFEKYGESKGLRILAFPSNEFAGQEPGTSEEILNFVKKYNVSFDMFEKIQVNGDEAHPLYKWLKSQEEGAGTITDGIKWNFTKFLIDKNGKVVSRFAPTTEPFSMEDTITKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5N5</accession>
    <name>A0A232F5N5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000946">
        <property type="protein sequence ID" value="OXU25789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F5N5"/>
    <dbReference type="OrthoDB" id="5919042at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08680">
        <property type="entry name" value="C2_Kibra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037771">
        <property type="entry name" value="C2_WWC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057747">
        <property type="entry name" value="WWC1_hairpin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25802">
        <property type="entry name" value="WWC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="878"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1477"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU25789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1527" mass="171228" checksum="D05594095D1674D3" modified="2017-10-25" version="1">MDRQYTLCVLVPAHQYRSYVDNYESTSSTGASQSPARTSASSKTRAYHPQYRIINNYQTRDDCGQLLLQQHHQLQLHHRRQQLRQLHQQQQQQHHHLYQQQQQQQQQQQQQQQLHYYRHNVYHQQNQKQNYQCQQQTLRSSKLQQQQQQNGHQEQIYENVVSRYQMRMCYQNDYENDEQIQRFYWEQCYRRDDSDATAYYYCEYAKKEIYDVKQQRLCLAQDEYNHLNNALSTLGASRTSLCSSSSSLSTKYDPDLLKCDVALARKRVSRLKRELEQIRAEMSCTQRGVDTLASVEQKLSSHHAGCYNITEAQAIMTELRNIQKSLSSGEKEKAELMQSLAQLKDELTRLQLCEGSPEASTLSLPQEKLSTASQTDLSGELVPIGTRLAEMARMRLQYDEARKRIQLIQQQLADLEEKVIPGQTESDKDKLLLFQEKEQLLRELRSITPHTRTQQDMKKIQCEIRRLEQDLNNAFELSNKTITDRVRLHEEKQLLLQQLRDALSLIHSISHNLLNLPIVTCARSMAMLEGQLKSLSASTLSVSSSSSLGSLSTTSSKGSLSSGLSFTDIYGGPQCMGTTQQERPVDMVDLHRRVERLLKGSEQSVTAVAAAAANSSSSIASSSSNNNNNNNTNTNNNNNSGGSNNNNNNLGTPSPGRSQPSLSPRSSLSSVSPPISPLYENAPVGPPPAYEQIELQRRQQLRLLASTTTTSHLDRMQLEDKLAELRFSQQTIQEQHCANTEHSHHHHQQQQQQQQQQQQQQQVQLHQQLQLQQQQPKHNAQTPMDLQSCNMSQGSGLGRPSLAGLTQEPPLSPISETPPPMGIRSRASSSGTNTRSVSAAVSDESVAGDSGVFEASNRRRLSGISGADTLMNNDANLETAQVQIKLRYSISDGLLHIGIERARNLAALYIPDSMQVYIKVALLPMQAPVNQVCCTKPVIDMRKPTFGETFPIAVPLNKLYTKTLQVNVWCTSGESEECLGSAQVSLADFSPETPSVKWYNILSCRFMQPSSSSDTNSTSRSSQSLSASQQQLVSKHDKQESDISMYRGSGQSSSSSACQNAKEESSDESTIISSQTSTLTRNQGCDELQTAVSLRLEELANCLKSPEEEEEEDGDSDSASGDSDDSDEEGIIVEFMMEESVLEDVLEHEEDEELAAAEETTVAANQTSDKETNTECVFIPEQGKQRRLSAAGVVPGAVHDDKNSIVIKRSQTFSPSAAVSRNHYICRLNRSDSDSSMPLYRRGGPFQRNSVERRSLRWRRPSSALSCKSPSTVSKSKSTHFPATARTSLDLELDLQAQHARLTNLHDELSRLRELKQRLEQAREKGDVDMASWLLEDDKFQNLMQQAENGKNGKSVEDKKVEKMLRKTSKEIYKLRKTKAGKGKPDIISFKEKMAFFTRINLNVPVLPPDESVVDKITPTGSDHRRYASEPSRISNNTASSRNVGSQHNYASRKSSSPAAVAVISTNSTATVAAATDKTSNDKIVRDPIESNEVAQTGDAQKSTTEEEDGEPKRYEYVVDRVLGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8B4</accession>
    <name>A0A232F8B4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000670">
        <property type="protein sequence ID" value="OXU27081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8B4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013212052" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7526" checksum="0742F259FD675658" modified="2017-10-25" version="1">MYPRFILLFVIVCCCIVFAVSDEKEEPLAKCRARCNRLYVKHRTDQKGKQTCYDKCTGIVDSMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8U8</accession>
    <name>A0A232F8U8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TSAR_016846</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Alberta</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000640">
        <property type="protein sequence ID" value="OXU27246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F8U8"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000719">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1598"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="183"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="288"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="370"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="471"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="562"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="656"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="755"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="856"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="985"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1090"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1192"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="1295"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1385"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="1482"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="969"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1666"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1785"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1820"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1787"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1823"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1838"/>
            <end position="1852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OXU27246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1852" mass="203749" checksum="2AFEEB5D21020547" modified="2017-10-25" version="1">MIKPSDCSSWRLIHAGLLRDCNIWQLLGNGTLYFPPFLAQDFRAEIHNARYRCRASNSVGTVLSREVTLRAVLTVPGYEVRVNRSPVVEGNNAVLSCNAREDIKEHLTVTSWYRDESILLPGSTDTGGRFVVTSQGDLHIKQARQEDGRATYSCLTRHSLTGETRKSEPASLPVTEPSSTMPPKLMQRSQIAISAERDSDVHLTCSAQGNPPPQFTWYRDVNGRSVPVESYGRTQLWGDLMRIRRVDVQDAGRYVCSARNQFGEQQAETHLSVTSKLNARIQPQLQVVNSGQTATMNCTVEGFPIESVEWLHDGLPVLTAQDTRIRLPAPLVLMIEAIGRRDKGMYQCLVRSDKENAQATAELRLGDTVPELQYTFIEQTLRPGPPVSLRCSATGSPPPSFTWLLDGDPLNEIASSHRYAIGQYVDQSGDVISHLNISSATTEDGGLYACLASNALASVGHKARLNIWGPPYIRLRIGPVRAIAGRDITIACPYSGYPITSVKWSRGGSALPPDLRHKLDNEGHLTITDVNKNDQGTYTCTVQAGAGQTASRDIRVEVQSPPVMSPLSFPPNLQEGSRAQISCSITSGDLPIHFSWLKDGEPLPSSLNIEETRHDFYSYLVFKDVSSRHSGKYTCVATNKAAKVNQTAELLVKVPPQWTFEPQDVSTLLGNPLYVHCNATGFPPPQITWLRGHARTSNDFQLLTELTDGRLTIMPNGTLWTASAGPQHEGHYLCRANNSIGSGLSKVVYVSVNEPARFEFQSKNVTIRRSESVVLDCTVIGDNPINVQWTHNNNRLDTNVHRLSISQVKTDNGLKSQLSIGLSDRQDSGVYRCTADNDYGRSEHFIYLAVQERPDPPSALEVIEIGSRSIKLLWNKGFDGNSPIREYVIQYQPVSHSIMEDDWEPSKTYNISHTPGSFFGIGANPGQNGVQRFEVTSEDQEIALVGGLHPAVTYKFRVFAINSIDTSEPTGPAVAKTQEEAPTQPPQNIEVTSAGPGELIVTWEAPPIESCNGDLLGYIVTWSEQSSSTSGVNQSKSLNVNGWATNKVQLTGLRNFTKYDISIRAFNSIASGPASVPITGTTQEGVPSAPPSRVTCTSLTSQSVKVHWKAPPAHQHGGIIQGYKVFYRPVPTDNMEISTTGEIKKTTSDETYLHTLYKYTNYSIRVLAYTGAGDGVLSDPIYCATEEDVPGPPAGIKALALSSDSILVSWLPPLQPNGRVSKYTVYFREAGSSRHNTYTIHEPPTSSSDTLTKELRDFNERQLYEFWVTASTTPGEGGASIVVSQKTDSKGNAAPARVASFSQVLRKPIKSSVTLSCIVVGNPTPRPLWTYKNSQVTKDKHHEITSDGHLRIHTLEQSVAGNYTCSASNTYGDDSITYTLIVVMPPRAPTLELQYTTTDSIKLFWNHPDNGGANIQGYVLSYKKDKSGWEEIALSPEHTEYTLTGLKCGSSYVAHLTAQNRVGTGDPSPLISAITKGTAPLVPKERDIIIANATSVRLYLLNWPNGDCPIEYYTVEFRKKVGAEQWNLVTSQATDNIIIRDLKPATWYSLRLTAHNDAGSTQALMDFATTTLSGVSIGPINDLVMDEDSMRSASSYKALYVAIPLACTIILIISAVVVGYVMLKRNGRGNYLGDILPGQQQTGLGLNPQHQPHHHLSSCMSTVQLKSTAERDNRRNHQVYTSSPVKQDNHKPPVDHGSVTPGMPLEMYEISPYATFSVPGRENRSVTTATLDYTMQFKTFGHLENEDINTIDYDRSSVDFERSKTPRWHKQRYFPSIAEAESKMRNNRQGSGSDTSGSPCGECAGPSYRVPVKTCRDVFSRGVESSTESNNEGSPSLGRRRNRQPSGRSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F906</accession>
    <name>A0A232F906_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000623">
        <property type="protein sequence ID" value="OXU27334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F906"/>
    <dbReference type="STRING" id="543379.A0A232F906"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7797" checksum="6B622AA972478A0C" modified="2017-10-25" version="1">MAEVKPDHKVEDGASYAMGNNVDPKNVQELTQYVQTLLQNMQDKFQTIIDDLEKNIGDLMTQAGVEGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F969</accession>
    <name>A0A232F969_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000616">
        <property type="protein sequence ID" value="OXU27376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F969"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="57" mass="6769" checksum="475F3D26DEFA92CD" modified="2017-10-25" version="1" fragment="single">MRCRRATRQLAIRYYFRSRDGERDARSTTRSTAEFGKITGFSTVLSLSPFLVFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9M5</accession>
    <name>A0A232F9M5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_012999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000660">
        <property type="protein sequence ID" value="OXU27133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9M5"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="291" mass="33339" checksum="25F111A4ED47DDDB" modified="2017-10-25" version="1">MKGLYCATFILTFSTIVMGWYRNKEIRSILQRMSITMRIIDKLGASKNYTKAFTVQVGYAVGTLTFLIIIVIINALVVYKRDPKHDSHVLTVMAVNYPLIILQVVDTLFINIIQYARKNMRVINDVLREMLTSTQDFPQHTKIVRRYLRTLDSPELDTDIVNQKTDAGDKIYTINMSKKAHLTLVKICQETDDTFGLHILLSVIVAVITITIRQFGDQIVQNSLTFKAHGFITLDFTLIQNVKNGIKYVSSFKCTLFYFNIFIMMQVVGFVTTYLMILIQFGSSTSIEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAL2</accession>
    <name>A0A232FAL2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Gamma-aminobutyric acid receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_010523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000520">
        <property type="protein sequence ID" value="OXU27884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAL2"/>
    <dbReference type="SMR" id="A0A232FAL2"/>
    <dbReference type="STRING" id="543379.A0A232FAL2"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000037">
        <property type="entry name" value="Gamma-aminobutyric acid receptor-associated protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="14013" checksum="0AB67C2634EA2677" modified="2017-10-25" version="1">MKFQYKEEHPFEKRKTEGEKIRRKYPDRVPVIVEKAPKAKISDLDKQKYLVPSDLTVGQFYFLIRKRIHLRPEDALFFFVNNIIPPTSATMGSLYQEHHEEDFFLYIAYSDENVYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAV2</accession>
    <name>A0A232FAV2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_000006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000581">
        <property type="protein sequence ID" value="OXU27563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAV2"/>
    <dbReference type="STRING" id="543379.A0A232FAV2"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF106">
        <property type="entry name" value="IP06960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="70"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="195" mass="21670" checksum="44D37AA45314F0BA" modified="2017-10-25" version="1">MAENKEPPTTAAEPESSLLAGFVSEVIRSPVNLALVAIIALLVYKIFKSRTKQDEPVQQIKELPKMRRDFTVEELKEYNGTQADGRILVAVNGNVYDVTKGARFYGPGGPYAAFGGRDASRGLATFSVVPGKDDYDDLSDLNTDEMNSVKEWEEQFKERYDYVGKLLKPGEAPTNYSDEEEEGSQQESENKSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBF1</accession>
    <name>A0A232FBF1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ALIX V-shaped domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_009141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000468">
        <property type="protein sequence ID" value="OXU28164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBF1"/>
    <dbReference type="STRING" id="543379.A0A232FBF1"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALIX V-shaped" evidence="2">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ALIX V-shaped" evidence="2">
        <location>
            <begin position="366"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="648" mass="72940" checksum="26C8790E158FC66C" modified="2017-10-25" version="1">MADIFSDLLPMAVHNAISNYESRKSDLVNCEIAKLRNLRQLLNGTLASLNLPAAIEDLSGTELPQSLIDKATFIHEAGGIKTLEKTMDELPELLQRNKDILDEGGVGPHIELLKGPERPTKIRRDSALQGQGAHSTYERNHLDPTKPSSRTTSTRTGRTTKLSASLRPRERGGKKHISSAATKKPLPTNQPGQRAERMLTEEEDSDNHLRLQFKERWTRLPSGRLTEQFKINSQKYRGIINNAISADKKKNSIMRYYCILCILSEKQTHGFANERRVAAVGRAGCSEFHLVSAVWSAAHRTPCGVGESCRHWVVLAWARCRGPRPDRSMRHQVYRLKPPFIREHFQYTIKNLQRITSALAAEASSPKSGNAVVREKFEAHRQSVQILSMEPKMIANTIPTGSAIQESHVVIELRNLMTEAETLTIEQDSIECELQSVNVDMQGEFLSALIKDGVIDENNLITENLNIAYGLLQNKILEIASRQEKLIEAIQSKHMEFSKEQSSSGSSREQMLCKLALAYDAFKEIKNNLQEGVKFYNDLTQLLVIFQNKVSDFCFARKTEKEEILKDLTSNLSQTDASDSLHIPSHHKDKARIQVPSYLPYPTHDQGMPIPYGVQTSAPYPNYMPPPLPTTFNPYATMAFPTQGNFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBU1</accession>
    <name>A0A232FBU1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000450">
        <property type="protein sequence ID" value="OXU28301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBU1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="155" mass="17666" checksum="EA641C04FFCF113C" modified="2017-10-25" version="1">MFSRGNKFGSFGAGKNRLFGKKDTSSKKHQSRMWIAMNKKRNEQQQQPSTSKNNLGLRDDNVADNAGALSFVMKVRAPTCVLGEKEWRVIGSTAADESEWVQFAKIAALCSRLDRKDSSLCLSMRRLQPDYAVPQFHSRRYYPPLYCTVRDVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC80</accession>
    <name>A0A232FC80_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_003348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000432">
        <property type="protein sequence ID" value="OXU28431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC80"/>
    <dbReference type="STRING" id="543379.A0A232FC80"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF84">
        <property type="entry name" value="ZINC FINGER PROTEIN 521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="512" mass="58442" checksum="92AF566CD20E5F5D" modified="2017-10-25" version="1">MELAAECSVFTDELLKTTSSASAITGGYLEEEVSYCINLVQSANTNCLFYTGIFIMDEEDPAIISGDVETIVIKPECIELLLFDAEDGEWLQESSGDSDPELTENNVDECCFVTSSGEVVTINNVDTVQTPFYLESYFMDNDGYRSRSPVHQNIIEIDRVTCYECDIVFCNEHRLLEHLMTHIDVYRMGCDVCDKDLNLEEKFQLHMMAVTWQSVYYCDFCRKSCAGVVRSRSQPPPPGKTYMCHDCEYHVKQETMNFQNTIQLYESVVNHPTNVPVKPPKETPPLIVSPALPQTPSVVEFSTTSLPAVQSAVTSTPPTEVLQDHKQKPNSDAKYEGEFYSIANPTTELQDCYIPHKSPPKKENMKCRRPKPKVQIVGESMRQALKLNTKSHLKDKSKTLKLKCRYCPATFSEDLNLMAHLREKHRLHKLRYVCKLCGKEFVQQRCYENHLSFHQLAKNHMCFVCNLAFLSKYELEQHAQMHDKSDIINTYCNNTTDCGALDLRKKKRKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCR1</accession>
    <name>A0A232FCR1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000410">
        <property type="protein sequence ID" value="OXU28601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCR1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="10787" checksum="7E7227651953CA09" modified="2017-10-25" version="1">MEAPIVVNNLPNNFKLGGETETELDDATTTSLNCGLRGWYKIKILDSGKKTFETPGIVRAADKDVARLALSLAKGKNAAIDPLRYEWLVRQVVFFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD08</accession>
    <name>A0A232FD08_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000415">
        <property type="protein sequence ID" value="OXU28565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD08"/>
    <dbReference type="STRING" id="543379.A0A232FD08"/>
    <dbReference type="OrthoDB" id="48306at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-SET" evidence="8">
        <location>
            <begin position="461"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="519"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="9">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU28565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="74182" checksum="8EE5829C9152B77C" modified="2017-10-25" version="1">MASNNIPTMMEEKHFGYGGNKSDIKVNDINATKDFLNTETGKHNNHIEPPAEQTVKVDESSKSDVVTIEDVHTKEKSRDTPDSESTATNKGYDYTSIGSGLESDVEDNTSEANSAPEKPQGNKPDLNIDDDLPSTVTLLKTSEGGKCYLLGTAHFSVESQNDVSKVIQAVQPHIVMVELCLDRVHVLQLDEETILEEAKNINFSKIRDTIKENGLYTGLFQLLMLQMSAHLTKVLGLAPGGEFRRAFAEAKKIPNCIVHMGDRPIKITFSRAISALSWWQSIKLSWHLLTDKSPISQKDVEKYKCRDSLEELMAELAGEFPALEEVFVKERDTYLTYSLQIACSRPLVGPDGEPIPPRVVGVVGMGHTLGIIENWGKVKRSQIAPIMSIPPPSLSGRILKFTFKASLVGSIIYIGYKYIPMPTGVIQSLKSSVAGLIKVSASHNIPGPGSRLDDFESEFSVGCSCDQTCRNDCLCNRGTANYVDGRLVLDKQSLIVECNINCTCAEICGNRVVQLGPLSCLEISEAKCNRMGFGLFTTKSIRKGQFICEYAGEVIGIEEAKKRLEENKAVGRMNYVLVVSEHIGEKRITTCIDPAKFGNIGRYANHSCQPNSVLVPVRADIVVPKLCLFAIRDIEPMEEITFNYAGDATDSVQSLSETPCLCGSGCCLGFLPHSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDF8</accession>
    <name>A0A232FDF8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000419">
        <property type="protein sequence ID" value="OXU28540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDF8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="7710" checksum="B42C60F6531CE86F" modified="2017-10-25" version="1" fragment="single">VTSNVNNNAAKQKNAVNIDERKYSFLTRGFLGSLNTNIATAILSEIPGAQFSRLMNTNVATATLPEVPCAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEF0</accession>
    <name>A0A232FEF0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000344">
        <property type="protein sequence ID" value="OXU29042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEF0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="12084" checksum="B5EDF5CC9A307E48" modified="2017-10-25" version="1">MATIKIEINFKHLLSKWGCGQVARCQLNNKYNRTAIGTTLQQQSSQTSGHLEFIYSHRVLVGHIEDSSGNQAKELGLANIKIKDNLKSELNFIIKFGVSTKPVNELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEK4</accession>
    <name>A0A232FEK4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_004561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000355">
        <property type="protein sequence ID" value="OXU28950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEK4"/>
    <dbReference type="STRING" id="543379.A0A232FEK4"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8451" checksum="A9A0839EF8CDD939" modified="2017-10-25" version="1">MPEPVHHQINTARKTFQALYKISKLLNTNLDPTTLSYCVRLCENGVNPQALATIVKEMQREAKALNSTSTYTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF32</accession>
    <name>A0A232FF32_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000331">
        <property type="protein sequence ID" value="OXU29163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF32"/>
    <dbReference type="STRING" id="543379.A0A232FF32"/>
    <dbReference type="OrthoDB" id="6162910at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="971"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="3">
        <location>
            <begin position="824"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1106" mass="121047" checksum="9253F68FA1FE90E1" modified="2017-10-25" version="1">MRNWKLVHENVSFVDAQQQAAYNSGPRYYNEPQQVQSSESRQQQSESVEYYDDEYYDDEAAEEGEVAPVKPVAPVAEVVVSSREPKTDKESSSNAKQQQQQLYEEDSYYYDDDYEEPKGEEHQHEQQQQEDEKRNDAASAGKKVFRKLNFAMELKTARSHISTAASDTSSSNSSPAPIEASSSEEPEEPINPPLGHDEKPEEQPSSSAASISPEPTPEEKVEEPDKNEESILIGEAIVSVVTTKSVVNGTFSVPDTTTLLPPTTTMEKEVVVESTLSPSTSTSSSTTTTTAAPETTSSTTTEFTPSSTIQASVQTGRSVSGARFLPFPSVQDKPEQLDSTESIIDKLDRVQSELSSGFLANSRFVPRRYNKKPFSITSLTLPTTSTTLAPTSPAIAPEPITSITKRPRIQTTLEDVSAFLPKDFPKSGGYRTSTTADPLTKRPKIQTTLDDVEAFLPKDFPKGGSYRTSTSTAPSTKRPKIQTTLDDVEGFLPKDFPKSGYRGGFKRPSYKTSTTASTSTTTTTQTVAASSTEKSTASTAKKALTTIEDISAFLPPGYKLKKEDATTEKSVVLSEILAKTKLTEPKEASAVSPSTIERSKTIPIQDLFAKSAVDISALLPPGYKPDANSPKSSSTAKPAIIPIEDLLVKSAVDVSALLPPGFKPDSSSDSSDPVKDLLAKSKVDVSALLPPGFGKNDATQQSTTTAKSNDGSFKLVFPSRPGGRKPISGHKLTTPSSIRGGGETPAPKIQKGWPTRATTEFTGWPTSSTTPISIEKLLEAARTATVSSLNASVVPTTSEISSTSSTTTTTTTTVRPTTPGICDEECEVAGTIKIVENATWVPELLDRNTREWQDLAEEIEREMNLVFAKSPVLRKWFRSIRIDSFSQGSVLVDYFVELADLKERINTQQLKVIFHDSLRTFDFDNPMEASPKGPMKLGKFIIDPKSTDFVVIPRAAAPKMLEDENRLIPQWAIAVIVIGVGGLLFIIVFGVSVLVNRQHGSKLKPSITAMYEEEVSKNVMSHAAPPSRPASEYQKNDSQTMWNDPGWHDKPFESTSHKILVDGLPYERKYNPYDSWKSEWNGYYYPPTQASSSNYSRHRPDYDINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF94</accession>
    <name>A0A232FF94_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_016234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000290">
        <property type="protein sequence ID" value="OXU29436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF94"/>
    <dbReference type="STRING" id="543379.A0A232FF94"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU29436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="83" mass="9518" checksum="FEC6A05D563A0131" modified="2017-10-25" version="1">MGRRKSNRKPPPKRKAIVPLDILFDCPFCNHEKSCEVLMDKGRKTARITCRICSEDYQTSINALSEPLDVYNDWIDACEASNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF95</accession>
    <name>A0A232FF95_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Headcase middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000351">
        <property type="protein sequence ID" value="OXU28987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FF95"/>
    <dbReference type="OrthoDB" id="10012848at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026066">
        <property type="entry name" value="Headcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031947">
        <property type="entry name" value="Headcase_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425">
        <property type="entry name" value="HEADCASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13425:SF3">
        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16002">
        <property type="entry name" value="Headcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Headcase middle" evidence="2">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="317" mass="34325" checksum="3988B53B6A9D8A3F" modified="2017-10-25" version="1">MTQFSIGVCIVGHFYEQTPRSVPQTSEHSIALSSVPGAMEDEGNHGNDDTRCFILSTLAALQWSRVSCVLCRAAMLVFDRYPLVDGTFFLSPRQHSASCAEVKVEGRTQFLSAVCMGCLEGSGGGGGXAMQVLHPALGRLQPRPRHHVQLRHLRGHALLHRASQVQQLSQAFDLPAPAAQLLLGLQPRLRLSPLPRGRRPLRQAADVLLHSRALPALQSLALTTREASRPDQRPAPAAAAVHFRALASSPTAAAADHGQLFFQPSDGSAQGDSALRSIHADAPRKTQARRERRLRITGRRLAKPGADIANKLSDEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF99</accession>
    <name>A0A232FF99_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein fem-1 homolog B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fem-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000337">
        <property type="protein sequence ID" value="OXU29109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF99"/>
    <dbReference type="STRING" id="543379.A0A232FF99"/>
    <dbReference type="OrthoDB" id="4429489at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF78">
        <property type="entry name" value="PROTEIN FEM-1 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="552"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="703" mass="78572" checksum="04B881977FA06339" modified="2017-10-25" version="1">MEEETEMSVSRMNRVYYAARDGMAITLYAMLNDNEPEYSNKLISQVSSSVLCLNVKQSKVWGTCLPMKSLRVWLPAKIICVGVSKQRSLKIKPRDLFFKVLQEDGQCCSPFIVAARFGHNKVVKMLLDKFTLDIEQEGRVKFDGYIIEGASALWCAAGVGHLNVVKTLVKAGANVNHPTKTNSTPVRAACFDGRLDIVKYLTDHSANIHIANKHNNTCLMIAAYKGHLDIVSFLLENGADPNEQAQYGETALHFAAECGHCTIVKELLKHGSKMTKNAKNMSPLISAAERARADVVDCLIEHEDVSKEDMIEAYELLGASFANDKDHYCLQKAYTYLHKAMALRYSDPNNIIKKVPGEPIAAYENWREAETVQRLEIIKNNHNAIHMESLTIRERILGRQNPDVPQPVIYRGAVFADNARFDRCIDLWLHALNLRQMNNMSISKDLLRFAQVFSQMIHVGVELKFLQVLNVLEASVVELGRNKKKLIEPEPKEDSDQSVSEEIESNITITLYILTILTKLMTLNEKGYDETDIKRAHHLVHKLCALQVTLKDGQTLLHLAVNADTPVDDFHTNDVCKFPCAATAKLLIQCGADVNAMDNERNTPLHVIVQYEKPISDFMTLHSIILDLVEAGAHMDTVNSQGKTPFDAATTGVAEIILRTQTKLSLKCMAAKAVKAYNLLYCGNVPRSLESFIELHGPGLNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG08</accession>
    <name>A0A232FG08_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_006444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000251">
        <property type="protein sequence ID" value="OXU29696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG08"/>
    <dbReference type="STRING" id="543379.A0A232FG08"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000198">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22994" checksum="68F9C0B66B9C87DB" modified="2017-10-25" version="1">MSDKDPIICIPGQRLCPADKTNIAGQGTYEQLGYIYSKFAGIVKVIKNDNTCTVEVHGMTDQSIVPAPGDIVTAMVTIVNQRFCKCTIKCIGDIVLSRPYRGIVRREDVRATEKDRIEMYKSFRPGDIILARVVSFYICIIDLPMTEAHTYQLSTAENELGVVIAHSEEGVAMVPVSWTEMQCPKTLVKELRKVAKIIPEEVAVQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGA0</accession>
    <name>A0A232FGA0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000288">
        <property type="protein sequence ID" value="OXU29459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGA0"/>
    <dbReference type="STRING" id="543379.A0A232FGA0"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="7">
        <location>
            <begin position="601"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="719" mass="82498" checksum="19D6CE6E5508508C" modified="2017-10-25" version="1">MDKSILLQKQIRDNSEDLQKELRDMEAWEEQMKKKDMEMRFLKEDKAIPPIRTKKKKKAEQAADVSRDQKPSKTKRIEGSDYKSWDKFDADKVCNEMEKNDKSNEKVEKILEIPSKEQLEKEHAEATKLKDEGNALVQKQQFTKAVGKYSEAIRIFPHDAVFFANRALCQLKIDNLYSAESDCTAAIKLDETYVKAYHRRASARIGLKRYKDAEQDLKKVLELEPANKEAAALLRQIQTKIEKTSAPMIISGGEKPENSTIEKQIGEKLLGKKSSPTSPTKSKALVEPSESKVEKTNTKETSKNENHSKQEKVNKIFSDEELEKDHLEANKFKDEGNTLVQMQQYAKAIEKYSQAIKIFPYDSAYFANRALCKLKLDKFQDAESDCNFAIELDNRYVKAYLRRATARLEQKNYENALKDVKTVMKIAPTNKEAVVMSKQIQMKIEESSRGSTSADETVIKKVVNKASNSMESESIKITHKHAEKQNQLLGSVKIPSQTESANNNGLPAWLPKLKEGVNIVESSLEPTSRQKQTMKRITIKEIPNDESIFEGAVKEKNKEKPEQVVTQDVKTMHQDGKSQTTTKIVDNTQSCMNNMEKIPPPPKSSVAFLLSWQKNVSPDFRYKYLKQITPKDLPDIFKESMESNIFSEIVFILNTKFIGNQDKIYDYLYYLAKLKRFRALILFMTQADKEALKNLFSHCKSNEGRTENEVNNLYSAYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH09</accession>
    <name>A0A232FH09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_016161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000247">
        <property type="protein sequence ID" value="OXU29729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH09"/>
    <dbReference type="STRING" id="543379.A0A232FH09"/>
    <dbReference type="OrthoDB" id="6344756at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF4">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280169" description="CUB domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="107"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="429" mass="46351" checksum="105B747300B50183" modified="2017-10-25" version="1">MSRLHLVLTLGPLVLLAVPSAQWPYPLWSTASQKPARNGLTSSSSSSSLLPRVLSFFPEPVAEECLSADKRRRGICMNTYDCRIQRGTFQGPCALGFGVCCVFTASCGGEVQNNLTYVTSPGFPNLIDQAMNCSVLVKKIEQQVSQLRIDFLHFNIGQPNRRTGVCDDDVMLVRSGEKTFQLCGWNSGQHIYVDIGEEPVTINFRLPGNLTSRMWEMRVVQLGFEQRAPAGCLQYLQAANGTLKTLNYLPNGRYLANHDYLICIRQEYGMCSVAYAPCTEDSFRIGGPNARIRNITTVQSPDEVDDGSGSAPESSGLSLTRCKDRVLIPCDFEEFITPGNDGAGICDLEHCGTTFCGSSGVSSTATTTESSEPTTVATAAAAAGSGCRVETSALPFHIRVAFGPGEDTGTSPEDNVGMCLSYEQLPCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH41</accession>
    <name>A0A232FH41_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000230">
        <property type="protein sequence ID" value="OXU29840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH41"/>
    <dbReference type="OrthoDB" id="5823474at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040308">
        <property type="entry name" value="HAPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31624:SF4">
        <property type="entry name" value="CHROMOSOME 16 OPEN READING FRAME 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31624">
        <property type="entry name" value="UPF0472 PROTEIN C16ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU29840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7720" checksum="39AAA44C6BEAC721" modified="2017-10-25" version="1">MSEDRSDEDSIMDLWYSNWEQQCVEGIQAEPDYEGQLQGEKELYSQQIWSSFQTTATAIAQLYKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIA8</accession>
    <name>A0A232FIA8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_001877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000163">
        <property type="protein sequence ID" value="OXU30412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIA8"/>
    <dbReference type="STRING" id="543379.A0A232FIA8"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17386">
        <property type="entry name" value="MFS_SLC46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="569"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113359" checksum="69AA24C378B5225B" modified="2017-10-25" version="1">MREPAQETAISSKSSVAACNIVVASALDDSTIMQNNNNKKEASTDESTSSSIGWKTMSIRQKCSYILRNITVEPMVAFYIMPSVLASLATQNLNLEKACKVNLGYSDAICAALAARNTSGLELEETAVQQLVASMQTWKTALQSFFPSILIVFMGAWSDRNGLRKPCMMLPIVGEFLTSISLIACVYWFYELPMEAAGVFEALWPALTGGWFTMIMGTFSYIGDITSVESRTVRVGAVNSFLSLGVPVGMALSGVLYIKLGFYGVFGIAAACYVFSFMYGLIVIKEAPRALELRKSIKLAQASELKRLTWWASVTDFFALRHVQETFRVAFKQGPRNRRKRVMVLMLIVMVLIGPMYGEMAVMYLFTRYRYRWNEVQFSFYSTYSMVINLIGTLFAVGVFSHFLKMDDALLGVLSCISKILASFVYAFSTTDWMMYIGKVNSLFGVCEAIVPLVYGPMYSSIYGATVNNFPGTFFLVGGGLMIPGVIAFLWLYMEHRKDDALEREQAAAQLAVANNKEPTKGGKQELMENRLENGLTLGKMRSNSTSGNVEVTELDNADRTLRKETEETSGWSRLPELILTQVFSLLSREDRASAGQVCLHWNRCLDSACLWRRCSINIDCDLSLDYSVAREMTLRYGEHMRVLELAWSKPYVTPRNTCRRQRYSRSKKNGACSAQVEAGVNFLELILMKQAQLRELLLTNWLYSGKWGNCAKLLYTLANLLACQQNLEKLSLLDANLAQSDVLRLLAIVARLAGGRLETLDLRGAFREWQAPLNSARFLRLLGRFSSLAYLSFDYPALSDGALAALASGASASLRLLHVAVQESDSRQHRLSDNAWRELVDVCPRLGVAYTILNLSDHEDLCFLLLPSVPLARFRMYASHVWDQNRTRNFRGTVGLLIAHYTNTLEEVKLHLIYNKEKMDDLIVSLLTSCKQLENIHYEGILRDFETLRDVCQLQLDSKTRWYNKIHLKPQNANVHNRALIQDIGRQYNRKLLQRGVDFRIESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIY4</accession>
    <name>A0A232FIY4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L55, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000151">
        <property type="protein sequence ID" value="OXU30543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIY4"/>
    <dbReference type="STRING" id="543379.A0A232FIY4"/>
    <dbReference type="OrthoDB" id="9986315at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.20">
        <property type="entry name" value="Mitochondrial ribosomal protein L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018615">
        <property type="entry name" value="Ribosomal_mL55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044884">
        <property type="entry name" value="Ribosomal_mL55_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09776">
        <property type="entry name" value="Mitoc_L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14360" checksum="CC571EAC3FCB30A2" modified="2017-10-25" version="1">MDQYEDPKMRMASKLSTLLKTAQVAGFASRNINCWTAAITKKHREVYLQTYPTLLQHSNGSTINIQYQEPVGVIRLPLDLTTLTEEEKKRRLEKRKPKTKIKIQDDIDDDFDENRYLKFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ87</accession>
    <name>A0A232FJ87_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSAR_015161</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Alberta</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="NNAY01000167">
        <property type="protein sequence ID" value="OXU30367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ87"/>
    <dbReference type="STRING" id="543379.A0A232FJ87"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="37"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="200"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="467"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="566"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="652"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="707"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1082"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXU30367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1174" mass="133679" checksum="D05149E408418AFA" modified="2017-10-25" version="1">MYAEEDHYEDEDTEEISSKVWQEACWIVINAYFDEKGLVRQQLDSFDEFIEMSVQRIVEDSPQIELQAEAQHTTGEIENPTKHLVKFEQIYLSKPTHWEKDGAPSPMMPNEARLRNLTYSAPLYVDITKTIEKDGEEPIETQHQKTFIGKIPIMLRSKYCLLAGLSDRDLTELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFSMKDGKYAFKCEIRSCLEHSSRPTSTLWINMMAKSGANIKKSAIGQRIVAVLPYIRQEIPIMIVFRALGFVADRDILEHIIYDFDDPEMMEMVKPSLDEAFVIQEQNVALNFIGTRGARPGVTKDKRIKYAKEILQKETLPHVGISDFCETKKAYFLGYMVHRLLSASLGRRELDDRDHYGNKRLDLAGPLLAFLFRGLFKNLMKEVRMYAQKFIDRGKDFNLELAIKTKIITDGLRYSLATGNWGDQKKAHLARAGVSQVLNRLTFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMLCPAETPEGAAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEIAPSAIADATKIFVNGCWVGIHRDPDQLMATLRKLRRQMDIIVSEVSMIRDIRDREIRIYTDAGRISRPLLIVENQTLLLKKRHIDMLKDRDYNNDGWQELVASGVVEYIDTLEEETVMIAMSPDDLKQDKEYAYCSTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPHKPLVTTRSMEYLRFRELPAGINSIVAILCYTGYNQEDSVILNASAVERGFFRSVFYRSYKDSETKKFGDQEEQFEKPSRQTCQGMRNALYDKLDDDGIIAPGIRVSGDDVVIGKTMTLPENDDELDSTTKRFTKRDASTFLRNSETGIVDQVMLTLNSEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFSCEGLTPDIIINPHAIPSRMTIGHLIECIQGKVSANKGEIGDATPFNDAVNVQKISTLLCEYGYQLRGNEIMYNGHTGRKINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDCQISHGAAQFLRERLFEVSDPYRIHVCNFCGLIAIANLRNNTFECKGCKNKTQISQVRLPYAAKLLFQELMAMNIAPRLMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJB5</accession>
    <name>A0A232FJB5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000164">
        <property type="protein sequence ID" value="OXU30397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJB5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="162" mass="18389" checksum="059277B36CB9D5BB" modified="2017-10-25" version="1">MVTLIVQELAIINQTEIITIPWNLDGSMITLFSRRCQLIYQSDHICYQILTEDAKGIIILTNSPLALAYPLLNKVTFFGPKIFGGTNLLGQGHKMDDNLGEFKVSEVQPLIIEGHQRRFEPLKTQAVPMMETPKLTKFGIEFHLRPSKSPQHTEIRTDDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJJ9</accession>
    <name>A0A232FJJ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_010426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000127">
        <property type="protein sequence ID" value="OXU30720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJJ9"/>
    <dbReference type="STRING" id="543379.A0A232FJJ9"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15065">
        <property type="entry name" value="7tmA_Ap5-HTB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000260">
        <property type="entry name" value="Dopamine receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01102">
        <property type="entry name" value="5HT6RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="131"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="493" mass="54662" checksum="A0321C9E7AEBCE42" modified="2017-10-25" version="1" fragment="single">SPLLTHFFPSSPFAQFHAIHKLLLRIAHPVINSLTFRLSLSRKKNTIIHGTIMANPSVKSSLEYRTQYNSRLINPKKKEEPGTNASLPLLRLLQSSNQTDGEELPDVALSLLSQLLVGLLLLLLIFLSVAGNVLVIVAICTDRALRRIGNLFLASLAVADLFVGCLVMTFAGVNDLMGYWLFGPGFCDTWVAFDVMCSTASILNLCAISLDRYIHIKDPLRYGRWVTKKIAWASIMTVWLLAILISFLPISLGLHRPNEPPVVHIVGEVSYPTCALDLTPTYAIVSSCISFYVPCIVMLGIYCRLYCYAQKHVRSIRAVTKLPEPSSLAKSFRSKSKRTKTPKPPTKAKPTSPYHVSDHKAAITVGVIMGVFLICWVPFFCVNIVAAFCKTCIPDLAFQILTWLGYSNSAFNPIIYSIFNTEFREAFKRILTKGARARYNQPSTSECGEFRSVVVARRNGSVVECNISPRSSADSCQVGTIGQRHRDTIVSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJL1</accession>
    <name>A0A232FJL1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000133">
        <property type="protein sequence ID" value="OXU30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJL1"/>
    <dbReference type="STRING" id="543379.A0A232FJL1"/>
    <dbReference type="OrthoDB" id="7699669at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="129" mass="14402" checksum="77F72B19C3741B47" modified="2017-10-25" version="1">MLSLPLFFSLTIHDLPDCLEHSAYHLYADDLEIYVRGKVGDADELVHKMNSDPANFSRWASADGLIVNASKTQAMWIGSRGYISQLLDRDLSPLYQDGSTIHPCESFKLLGVMIDNTKVPIVSLHRAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJL3</accession>
    <name>A0A232FJL3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Protein kinase C and casein kinase substrate in neurons protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_009860</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000121">
        <property type="protein sequence ID" value="OXU30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJL3"/>
    <dbReference type="STRING" id="543379.A0A232FJL3"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07655">
        <property type="entry name" value="F-BAR_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11843">
        <property type="entry name" value="SH3_PACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000014">
        <property type="entry name" value="Kinase C and casein kinase substrate in neurons protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000009">
        <property type="entry name" value="Protein kinase C and casein kinase substrate in neurons 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF11">
        <property type="entry name" value="SYNDAPIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="17">
        <location>
            <begin position="11"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="450"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="359"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58649" checksum="6591F36A3E9BAA77" modified="2017-10-25" version="1">MSHHSDDNMLVATSDSFWEPGNYKRTTKRIEDGHKLCDSLIQLVQERAEIEKNYAKALKGWSKNWNEKIEKGPEYGTTEAAWKGVLGEADRLCDLHLRVKENLCNDIIQQVKTWQKDSYHKSMMTLKERKEMEDAFKKAQKPWSKILQKVEKAKSEYHNSCKTERTAANQERNASADSSLSPDQMTNCGCDAWALRFRKTFRKTKIGDVELVKKMQDRVQKTKEEVQKAKEKYESALQEINQYNPKYMEDMTQVFEKCQEMEAQRLQFFKDVLFGIHKCLNISQDPVLPQIYEEFYHTVNNADHEKDLKWWSNNHGVNMAMAWPQFEDYTEEFRDITKGSKSKEALPTGAITLINQRPVGEDLHDFPPVNHKVKAKPASRVISTDANHSDSKTDTISSKPPAEKNNHDGNSVNRNSSITNGTNNAKQESNPFEEEEWDEDAGEPLVDNGEPGVPVRALYDYEGAEADELSFKQGDIFEKLEDEDEQGWCKGRKDGRVGLYPANYVDLVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJL8</accession>
    <name>A0A232FJL8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000132">
        <property type="protein sequence ID" value="OXU30679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJL8"/>
    <dbReference type="OrthoDB" id="7701400at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="199" mass="23102" checksum="AC0ED7F0C903C421" modified="2017-10-25" version="1">MADDLNQTREQILEMPDVGQRIAALDQLYRVQQLERDRQLLDLSRSMIEASQTQNISRVVMHILEYDGTNLNLKEFIQDVENGFTLLPAEQEPQFLRFVISRLKGKALESCVNGLPDGWRTGIIDTAPQTLTAAFNTAIKYEKARIKMYGEGYEYPRVHYEYCKPDRAPNEREDPGNYQHFVSHRKHEDSESHPQKGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJR1</accession>
    <name>A0A232FJR1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000105">
        <property type="protein sequence ID" value="OXU30915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJR1"/>
    <dbReference type="STRING" id="543379.A0A232FJR1"/>
    <dbReference type="OrthoDB" id="6076990at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="2">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="522" mass="56788" checksum="E41169C4B86A4820" modified="2017-10-25" version="1">MTIYKEQQNFTQNGNLRAHYTKTTIRAGEVLRLVAIFQDTRRCGSMSFSIAGNSSERDQYAQCLDPHGREVFAPLSARGEFYAVCQSDASGIDTGSDALLYKVHQLARRQLPLRVRLIAGPLPVPLPREYGGLMQLESSTRGPIVLGCLVPETPVYNPEMLELLVSGNGAPRVRRARLGYPSEARLLASPKMQRLLTACSRAVGDRATEPRVAPQKLHSEDENLKEMHLKKIKPKPETKPILQSLREGLEQLKKPAASLNSSISSARESKIDRTRNNSTSSSSNPSNNNNSSSGAGSGGGGGGGGGGGGGFLERINKLRQASRSRNPAKKSASFTFAVRPEIAMKAAQKYSSLEPSESGSQNQPIGGASSKQPVQRSISTSVLEVPPASSSSANVQLQPDYSRVRDSLAPATPTPKPEPITVLKPVVNDEIYAEICENHVPVRPTPPPPRPPSPNKCPGSHVMARIKILVKEDHQYKPERDVIDGRKLDRKYVNSIFVTSSHSHHQDSIVNAEDEIIYNTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKG9</accession>
    <name>A0A232FKG9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000099">
        <property type="protein sequence ID" value="OXU30989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKG9"/>
    <dbReference type="OrthoDB" id="7635470at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11541" checksum="A87E96FC7D8AA62F" modified="2017-10-25" version="1">MDRQIPYSTLAALRGILISSLSRENLGPHDLSLKQQLSRRQSLRKVHFPGEYEHCVCRKSQAAYHLLQRCSSHTLESHRTTPSSGCRGKFETNSSSDVAQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLC3</accession>
    <name>A0A232FLC3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000064">
        <property type="protein sequence ID" value="OXU31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLC3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="85" mass="9700" checksum="F491EAC80F063323" modified="2017-10-25" version="1" fragment="single">DCDITQLSAENRSECSDLCVSTPRARERRLQGVRVDPLWRMLIGLPRSLSSKFHNCVNRYRDFKNPGADPRSAFLRSDLLTGGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLP4</accession>
    <name>A0A232FLP4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_004707</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000057">
        <property type="protein sequence ID" value="OXU31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FLP4"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF29">
        <property type="entry name" value="KINESIN FAMILY MEMBER 20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="276"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1101"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1432"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="720"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="839"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1445"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1517" mass="174354" checksum="2CD6FD84D35C7304" modified="2017-10-25" version="1">MKFRCKMDDAGAMRDFTNVATTIARMSKQCVLRLTQDAVYFNAADESTPMVWTRLDQAHFFREYLVEGKSEQFNEIYMELNTAMLSKSASTIKNSAKSVKIKLTNKQQACITFAIELPSISAESRLCVHDIPVTIVSQKRWSEYNEPHYDKFDISLQMPQFKHLRSVMERIKNMSPVLELAVDTNGTLAFKADADSATITVHFPSLTVYECNATDETIMASVDIKKFHAFLAWDAVHPSYIKCHIIHNRMNSTSGTQSSENESLRGDMSYLYGRDPSILAYSQRPFPSQDSKKNLMNLLEEEDESVVDADEKTSSLSSSAAIDQTIKTFGPDTTQLQLFDQAVKPQMVDFLAGKNSVVMSYGTTNSGKTYTLQGTPESPGLIPRGIEFVFSNITPRAMPSYKPVNQCDVIHLNHHDRVQETELKLKLLTFNPADKIMYVNTYKQMQRLLHAESPIRPSHNYNAQYSVWVSFAEIYNETIYDLLWTDCQKKRPALKLASDGKGRAFIKGLKSVCVNTGAEAYQVLMAGQYNLKVAATALNSRSSRSHCIFTIKLLKYRTENDPYSVEVSTFAFCDLAGSERLKKTLNVGERLKEAQNINTSLLVLGRCLKTIYESQCSTNKKIESIGPFRESKLTRLFQRALSGKEQISMIVNVNPVPNLYVETQNVLNFSAIAKKIVIEPIETIKRRRSHSRFSRLCTQSMKTDLDWENTELEDMTEASEDCLEEESDMLENDQEAYEDLLTENELLKKEIKELKASALTRDMQTRQEMTDMYSEIMKKLEADWKNRLIDLEEQQEDLRELAVERIELFYKEKLSQLNVRKRSRPSMDGDEEDDDQKLLQDLEVENTRLIAKMETMKKSIRALKQTKEEAETAKTKISFELAVAKEEAKRANEMFLAAQKSINSGDDVSATYIEELNDIIKKKDDRIKTMKTFLNEAKEEYISITDQAQKLEEQLKERDELLVENSEQIRDLEEQLGQANAYSAEQNKVIENLEEELDQLNKKLIETEEKARIASEQMQSVDATEINKKDELETEVVNEELDKTKALLEEMKLRLELSENDNIQLKEKLNQRVTEIQLLKNNLGITKNQLDKLTEKVDSLTINDKSEEESSNEQRNIETAEQETQTEKIDSPVKYIKKETAPVMANISLQTIEFEGPKVDTEELSLQTSLEIISMEVFDELKKQYEELQKTLEGCKFDKLEAQEQFEETIKDLQTQINVLAAQEMEKSEKISTLQKELDEIVKDSEKDKAELQALVTAQDDKDRILMDEMAKSLAREQEKDSEISTLQKEMKKLITSNDEMAKKMEVEMKVVLKDLTSTKTKLADTEEKLRKVEKDYMQVIHILEMKISTLENKILEKQGENEKLKLRVEEYKKSLIDKEHEMDVFTRNRNTTVEKYEELVKSQNEELDRMRREITRLQDLLQEVKENAVFPTPRKGSTKKSRCNVREEKKKAKNAETDATDMTSEDDHDENLKSSRKGKKEFLSPTIDNIPIIELSGSESNLLLVRLGVYEIEGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLR1</accession>
    <name>A0A232FLR1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLR1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="274" mass="32086" checksum="F4CF1D38911E67DB" modified="2017-10-25" version="1">MPPQTEQETFRKNMNELLLATNSVANSKPPSPNQLSNLFAAVLTSHRSPAHHYCIVKHRECQKISATNLDLNCFKPFCKWFSVLYSQGKVPNPNSPILMIFIYVVEHEKIRDTKRSPGVKMILRLTHYSYGKRRLHLMSKYQNHLPYGETWSVISRFKYTTNIPKTILLSVNYVLVSKSPPGWRDMVSKSVPAWRDIAYDTMHYKYTTNVLKKIFNYSRQCPGTKITFRMDKSCRWCPGVRVILRKTKIPRSPEKFPEKIKKMRLDQKQLFAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMK7</accession>
    <name>A0A232FMK7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000019">
        <property type="protein sequence ID" value="OXU31885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMK7"/>
    <dbReference type="STRING" id="543379.A0A232FMK7"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="212" mass="24167" checksum="71DC9BD7486D059A" modified="2017-10-25" version="1">MDTTEKETSIKLQALDQFETLLNNKEFSDVKFVVEGKAIYANKVILISRSSVFSAMFRNRMKEAQEGAVEITDVEYNVMLETLRFVYAGKVNEIEKFSKSLLATADKYDLGGLKEICTDYLCTNMSVESVVEYLSLADLHNVQRLREKAIKFIIDNGNAMVNRPEFDSIVDLHKGAFLDVVRAVLAREKIEDSRSRRCGKKFSTTNNYISFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FML0</accession>
    <name>A0A232FML0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000046">
        <property type="protein sequence ID" value="OXU31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FML0"/>
    <dbReference type="STRING" id="543379.A0A232FML0"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12535" checksum="19737762AB432E20" modified="2017-10-25" version="1">MRRARTPKAPVGASSMVEPIRDPVDGCYPSRFRAKTVSKTITDCKRIRVYPIQPPVATCINIDPRKLSTGRYVGSRPIKLRKSSWKQRNLDTVRKKEKEKQNLIGLLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMX3</accession>
    <name>A0A232FMX3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000012">
        <property type="protein sequence ID" value="OXU32022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMX3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="209" mass="24968" checksum="9371245B9CFF5A05" modified="2017-10-25" version="1">MSTFGPVRKKIFKMDDDSSLIEDQMQILREYCSRIIQYDLKQIFRQLKEESINKTTKNLIREIVRIESLCFNEPFFDEEDLVSFNKPKLLNYYKMCQAEMSAMNYNKFEVMNALKKEFKTKNYENLCTIYASKLAKRFTEVPNKPMTLKEETRDHFKFTEFVKRIGFGLRDKEPVVSKKLNISNYYLKYQDELMAMENGRIKRARAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN47</accession>
    <name>A0A232FN47_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN47"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="308" mass="35584" checksum="301E6B00DAAA96CF" modified="2017-10-25" version="1" fragment="single">TLKAMECTTSIASLSTACTWTVIITDLNIFVPRSTVRTDSVIGNPRYAWHLWPILTRGYKNLQRAIYIDRYRSVIEDSSLSTQISNVTGYRETIFAYMYKKSRNPLRGSRNQLPRILRKFVQRQCGSRSKTTVKPSRQCKHIYSAQLIDICGKKSVGMRYLTVLLIEICEKAIPNCITYNSLCYQLYGPTTFRLECQLRCPTSLEKKVEILFWAFFLCPVIRDPEYSESLGSDSTAGVQKHNFKFQADNKYVGKRYPTVFLIEICEKAIHNFITHNSLCSQLHSLTTFRLERQLHGPTTLEEKVEILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDC5</accession>
    <name>A0A232EDC5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006950">
        <property type="protein sequence ID" value="OXU16347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDC5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="22159" checksum="C07DEC87FACE5CEB" modified="2017-10-25" version="1">MSTLDSETTTPSQVAPNITTLVFTMEKLLSSTKTGFKSRRNGVEKEQRGTLDTVKLAFREKVRKLKKRTIISKKKIRKKETIDSDKDGLNSNQNSEESDEGNEEKSDHDINDRTTNSKNNIENENYIIDAEKEGSDSDDEESTGRNDHKYDDNNSPKDNDQVFASYEKKMNEQEQDIKDDGSTTHEEIENEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EED1</accession>
    <name>A0A232EED1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005424">
        <property type="protein sequence ID" value="OXU16688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EED1"/>
    <dbReference type="STRING" id="543379.A0A232EED1"/>
    <dbReference type="OrthoDB" id="5979489at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="123" mass="13545" checksum="CFC1472933773232" modified="2017-10-25" version="1">MPPTQTVIESSHWVQYKPISSLTDQAPIEFTIPGNCEYLDLADTMLSLRVNITPTKPFEKDASVPVVEPGYLYVDVLNMDRLLLGGVKFFKDNKGRVLPKKVGLAVLELDVTAHGTIAPTCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF24</accession>
    <name>A0A232EF24_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005148">
        <property type="protein sequence ID" value="OXU16947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF24"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9712" checksum="34A05E8A4FC4BFDA" modified="2017-10-25" version="1">MTKTSLYRSQAYRLRAVIYRQYNFCVRHDKVVVDKDRPLPFTGLQDTGCVIIYCDDACAFKKRSDKKVKGLQDLRRHKKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF38</accession>
    <name>A0A232EF38_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005125">
        <property type="protein sequence ID" value="OXU16970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF38"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012082214" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7550" checksum="6AA5700C02C3C6A4" modified="2017-10-25" version="1">MLQIPLKLLKTTLILSTLGTEYLGGCCRRDIRVQRPPKPLSSKSGLILINIMHRMRLFIIYKFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGC2</accession>
    <name>A0A232EGC2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ionotropic receptor 75a N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004788">
        <property type="protein sequence ID" value="OXU17409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGC2"/>
    <dbReference type="STRING" id="543379.A0A232EGC2"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="474" mass="55401" checksum="1AF177DDB5383F05" modified="2017-10-25" version="1">MFGELHYWVILGSDLKNLFELIDDRAFGLGTDLIAVVPLNDTEDRYELYDVYSISKERGIPMKVTLFGIWNNQEGLNITLLQTKFERRSNLERLIIKATYFKLIYRPDNMSLEDYFNDYENSVGDAITKFGFQLISHLADLYNFSTSLRSGAKRRVKLNHLSQEYPQTAKILKSRLFVTKVVLICTMGLAHERTYNEFGKLHMKMASEAMVYLEFFLKYYFPYEIPSFLKLPENEKLMNPDKGMQLVEEGGLAYHMHPVVCYPIIDKLFDNREICELMEVHVARPTRTAFGATMNSSFVEIARVGFTKINEVGLRHRQYLKWSHLKRPCRKDILSAASINIYEFSPYLLLLAVEIMMSTTLCLIEVILVNHGMCINIRNIVCTEHVSVSYRSFKPRDRRTNESRSFESFLQKPDWESQIFYQIYCLKLPESEQYRLPEVGMQLVQKGGYAYHTHPDVGYRLIHKYYTSNARFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGZ0</accession>
    <name>A0A232EGZ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_002433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004636">
        <property type="protein sequence ID" value="OXU17626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGZ0"/>
    <dbReference type="STRING" id="543379.A0A232EGZ0"/>
    <dbReference type="OrthoDB" id="6656697at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012308278" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="126"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU17626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="371" mass="39195" checksum="FD998C89A903B923" modified="2017-10-25" version="1">MFRLTVILAVCCHWTGVRGQFENGIVFTNGDNSIGTVYPTQSAAITTTIANQKCTCVLAGTCPTGGNGIDIRIVNNAFDVQITKISQGPPQTPCPAGYVSCCSPGNQNQVDGTCGIRKITPTQQPVVGQASFGAYPWQAALLNSQQAYLGSGVLLDATHVLTAAHKVAAFVNNPTGMLIRLGEWNARSNSEPLDPVTVNVVRITLHPQFNANNLENDLAIITLNGYVNIPSYANVNTACKPTTAPVTGRRCYVAGWGKNLFGPNGSYQSILKEVDVPILDNTDCENRLKQTRLGAAFVLNRVSFMCAGGEAGKDACTGDGGAPLVCQKASGQWEVVGIVAWGIGCATPGVPGVYTNVFNFLPWINTVVATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHY3</accession>
    <name>A0A232EHY3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01004393">
        <property type="protein sequence ID" value="OXU17955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHY3"/>
    <dbReference type="STRING" id="543379.A0A232EHY3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF116">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG5065-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="363"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU17955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="514" mass="57939" checksum="A16690D91F739402" modified="2017-10-25" version="1">MPPRSISEMTADSCVFLTGVTGFVGGCLLERICKLEPGPARVYVLVRRKLGVEPQSRLEKMFSSPLFSGIPASKLQRVQAMEGDVGSNEPDLGLSPKDVQILVDNCTHVYHSAAFISFAAQLEQAIRINLRGSRAVLHLARRMKKIRAMVHVSSAYVNCTIGTENSEFEERVYPVEYDVDPVDVLNAVTTMSLQEVEKEYGELIRRHPNTYAFSKHLTENLLARERGHVPLSIVRPSVILNSWREPFVGWVDNVNSGACGYIAGVAKGIFCTFQARADMVMDVIPVDMVVSTILAAAWKAELEPERLHVLHCTSGTANPLTWGRYADGIIKAAREHPCHSVAWYPRTTLRESRLRTELVMFIFQMIPAIFIHLFAKLAKPEHSLIDIQRRYAKGGKYTSYFSVREWQFSRKTSDELAAMLMEEERDRHPMDPRLLDWDKYLEGCVIGTRTYFHKEPAKTTDRARRQMARLRVIAALSPVLSFTGLCGCFALLMGIHWAIAVPLAAFIVMLLVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI29</accession>
    <name>A0A232EI29_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="10">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="10"/>
    <dbReference type="EMBL" id="NNAY01004368">
        <property type="protein sequence ID" value="OXU17994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI29"/>
    <dbReference type="STRING" id="543379.A0A232EI29"/>
    <dbReference type="OrthoDB" id="25346at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037994">
        <property type="entry name" value="NDPk6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46956:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="11">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU17994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="185" mass="21485" checksum="E95B708AB8B68046" modified="2017-10-25" version="1">MSSRPSLQLTLAILKPHVVKSPFALQKIRDIIIQNDFKIVRTRRTIIDTKEAEEFYKEHKEKFFYNRLLTFMCSGPSDVHILANENAIVKWRQLLGPTKVFQAQYSAPNSIRGMFGLSDTRNAAHGSDSPESTEREIKVFFPDFDIKEWYKNEEMFFSSGKLRLDPDLFVHIVDKNVLNVTENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIX4</accession>
    <name>A0A232EIX4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004150">
        <property type="protein sequence ID" value="OXU18294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIX4"/>
    <dbReference type="STRING" id="543379.A0A232EIX4"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="246" mass="28323" checksum="E53A01E1ADBE9C17" modified="2017-10-25" version="1" fragment="single">KKSNQPNSLDNLRPISLLPTISKILERVINKSILLFCENNNIIPDCQFDLKKKHSTVHAINLLISTVNRCLNENEIVGACLIDLKKALDSVWLEALIFKLDKLNMPVEMLKIIYNMIFGKKFITNINNVESKKTFEITRGLQQGTVNSPTLFNIFNSSILNLFEVNKENSSLYAIAFADDLIILTAGHSIELVQQKLQDLYVKIKKFYNNWNLEINPSKCETILFRNPINPRMNKGIRKGWRSFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJB1</accession>
    <name>A0A232EJB1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">MOG interacting and ectopic P-granules protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_002733</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with hda-1, let-418, lin-1, mog-1, mog-4, mog-5, mog-6, pie-1 and unc-98.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004056">
        <property type="protein sequence ID" value="OXU18435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJB1"/>
    <dbReference type="STRING" id="543379.A0A232EJB1"/>
    <dbReference type="OrthoDB" id="6110130at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001612">
        <property type="entry name" value="MEP-1, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="589"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="417"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU18435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="638" mass="71446" checksum="A94944888EEDCD34" modified="2017-10-25" version="1">MSETREKGIEFVTQDLKNSSEMNAMKDEAVFPEHSMADVSPQGDASYEFLEFISMDPSRTDKSATSDEDTLPELEEVETKSNDREECTDAASTVSADKKSSLANVNLKSIETAQTSSSEMQSVSTETESVSVCAETQKQTPVTQTSAIPKRNLHDTGELQEDIVIAPNKDKITLDRCSVRSAILQRNINDHMTKAKELSDCFISTQSRYAEEQNIIGECASMINAVESIKLADDKSLAGNDLTEYEKSLTNYRKKLISVQIQVVEDRQKMISVEKHYQKILSDYRRLVLELESVQLENEKMTLIEKEKQKKYAAIEKNLDERNKRLSEEKASLIKQQQSLINEKALVYEAMMNSIRTLELEKEKLLVGRKCFEDLGGKLADRPEPISHELQKPIPKKTICIKEQQALQQQLNAAQQRASMGIQRPTTPTKTAPQIKLSGDNRVAAQTDTPANAPQPSAPVSKAQANPAARNKSATNFVTCEICDVHIEDPEQLRNHMQWVHKFKIHPKMIYSKPPLNCQKCNFRFYTDQGLERHLLRSHGLVTSTMQEAANSSKDGGRCPVCGNIYASKLLSHVARDHGMTLKPAHLTYRCTVCAATFSVYEQFENHVYSAHSSVAKHAMDKKGGGPCALTSRPNDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJU0</accession>
    <name>A0A232EJU0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small integral membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003942">
        <property type="protein sequence ID" value="OXU18617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJU0"/>
    <dbReference type="STRING" id="543379.A0A232EJU0"/>
    <dbReference type="OrthoDB" id="5913955at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027858">
        <property type="entry name" value="BRAWNIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028183">
        <property type="entry name" value="UQCC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35250">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35250:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14990">
        <property type="entry name" value="DUF4516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15114">
        <property type="entry name" value="UPF0640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16126" checksum="0A70930D278FB478" modified="2017-10-25" version="1">MVLTNSIRWFLNAIPGKKYFAEYRFLPIFFLGGAALEYFMIHWTVGETNFYRTYKRRQVDEIIERKEKASLLDSGVIAMPAGVSWPRYISFFAVSMLSSYAGSQLVHMYYKPLDDLDDMVQEELERRRKAGLLKSSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK41</accession>
    <name>A0A232EK41_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003884">
        <property type="protein sequence ID" value="OXU18715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK41"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="356" mass="38872" checksum="BF4744DA646B59BE" modified="2017-10-25" version="1">MTSVNSANELNDFMCNSKTVMESEKFDLRGWEYTGDGVSKNPTNVLGAARAKLASMNAKSSSLTEADLEKRFENFFQTKTQQSGPSSSKASGSRKKSGNNTAYSGADNSPKQGDSNQAWRQNSLLELQLAWLYEVHLSGLVLLRAVKKRERERVDKVPTALENLRTFNTTSVIGVAQTLHGTTSDSPLAMSNPTDVESSCDVGTVANALVEKYPRWWLAVDVAQYKFSGIYDTGASRTVLGPIGISLAASLHRRVQPHVGPGARAVLPFTVRGITHLIDVLILIKVEAFSAMLDPVTNKLHLKGTDVKVAAALSSARAKEVLSFAFLRIKAITEEQLLEIDNLMKELLTDYSYELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKH1</accession>
    <name>A0A232EKH1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="NNAY01003794">
        <property type="protein sequence ID" value="OXU18857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKH1"/>
    <dbReference type="STRING" id="543379.A0A232EKH1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU18857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="346" mass="39003" checksum="9C9B407A9AEF8022" modified="2017-10-25" version="1">MKGETISNGELWQTAEGVLKRFDKDQDGGLDFEEFKELCLELFGADEVEQHESKLPDLFNALDADGDGILKDDEWESCFSEWIRVVLNPVNVFLIVDVQNDFIDGTLALKDLGLGQDGSDVVEPINQLIEECPWNKVVYSLDWHPPNHIGFYDNLHLRELHPDSKVKKEDAKLFDTVLFLKPELEQKLWPVHCVVDSWGAQLHKDLIIAPDSIQIRKGQDPDMDSYSAFYDNDGVNTTELPKILQELGATDIYICGLAYDVCICSTCLDGLRLGYRVALIENCCRGVDPNEVEEARRKITEKGGLPLATENVKDHVVGEKRSLVMALQGAKNLAKRREAARENSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKV5</accession>
    <name>A0A232EKV5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003723">
        <property type="protein sequence ID" value="OXU18948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKV5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="45" mass="5361" checksum="E8CBCB25A4DB531E" modified="2017-10-25" version="1" fragment="single">IKWRGSATKASLRSRRSRSARAIIYFYIGVRIFHLQKKNAYHYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELC2</accession>
    <name>A0A232ELC2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_001555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01003583">
        <property type="protein sequence ID" value="OXU19154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELC2"/>
    <dbReference type="STRING" id="543379.A0A232ELC2"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU19154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="359" mass="39787" checksum="591B8699EB5528C1" modified="2017-10-25" version="1">MLHLCGKLSNSQLLFQRLHYGKSFFRPATTMSVRDALHSALDEELARDEKVFIMGEEVAQFDGVYKVTKGLWKKYGDKRLIDTPITEAGFCGIAIGAALAGLRPICEFMTYNFSMQAIDRVVNGAAKNLYMSAGRYPVPIVFRGPNGNAKGLGAQHSQCFAAWYMHVPGLKVMSPSTSEDYRGALKAAVRDPDPVVILESELLYNMEFPVSDEAMDKDFTIPIGKAKIEKPGKHITLICHGQATPYTLKGAEILAGEGIEAEVINLRSLRPLDWETIFKSVEKTHRLMTVEFGWPRCGVGSEIVATVMENPVFFQLDAPAVRCTGVDVPMPYSEKIEYECTPKDHHIAEFAKKVCGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELD3</accession>
    <name>A0A232ELD3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein anon-73B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0239 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003597">
        <property type="protein sequence ID" value="OXU19128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELD3"/>
    <dbReference type="OrthoDB" id="10040809at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009621">
        <property type="entry name" value="UPF0239"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14409">
        <property type="entry name" value="MANNOSIDASE, BETA A, LYSOSOMAL-LIKE, MANBAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14409:SF0">
        <property type="entry name" value="PROTEIN MANBAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06783">
        <property type="entry name" value="UPF0239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU19128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10172" checksum="06F7DDBF6B24FFF4" modified="2017-10-25" version="1">MADYDPQLKRLLLPPEESFFEVLIRYGLYVGAVFQVACLLAIVVYHGSSSDSIAALKDDPSDIECSENSPQVTPRRPHRPRKQEKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELE6</accession>
    <name>A0A232ELE6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_001552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003583">
        <property type="protein sequence ID" value="OXU19151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELE6"/>
    <dbReference type="STRING" id="543379.A0A232ELE6"/>
    <dbReference type="OrthoDB" id="3363059at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17979">
        <property type="entry name" value="DEXHc_DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000013">
        <property type="entry name" value="ATP-dependent RNA helicase DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000540">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000725">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056382">
        <property type="entry name" value="DHX34_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF221">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24485">
        <property type="entry name" value="zf-C2H2_DHX34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="287"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="485"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU19151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="144542" checksum="5E0B3DBE20748214" modified="2017-10-25" version="1">MKKHKSNKSRRNNDDHRRSKKKKKKHESDSESTSSESNDEFQKKPKHRKHKYSSGEDSSDSDKEHSKRKSLNLEKPKNYFDDDTVDNIVKNRRHSHDDVRKHKDKDHHSSRNNERQKYDDREAGTSREHRYSHSRKHEKRKNAQSSEDEEDSDFSFLKYKYGLNRVLLSLNLVRDLEEFWIFVKKYELMEKKNPKQNKNTSSNINELGIPEDYDKFHRLNFSINCRTKELLLRVEESRELTDARLNKFKDIVTIYVDFKQKEKFQKLKKLRTEQANLPVAQYRDEIVEAVKTERVVIIAGDTGCGKSTQVPQYLYTAGFGQIACTQPRRIACISLAKRVAYETLTENQNEVGYQIRFEKQRNKNTKITFITEGLLLRQVSGEAELSQYDVVVLDEVHERHLHGDFLLGIMKCLIHQRRDLKLVLMSATINIELFSNYFANEDVRVIQVPGRLYPIQLIYKPVLIEDKYSKSERFNPSPYIQIMQIIDKKYPKNERGDLLIFLSGMSEITAVVEAAKEYSQKENNWIVLPLHSTLSIADQDKVFGYAPEGVRKCIVSTNIAETSITIDGIRFVADSGKVKEMSFDPICKMQKLKEFWISKASAEQRKGRAGRTGPGVCYRLYSGDDYSAFEKYSTPELQRVPLDSSLLQMIAMGLPDPRKFPFIEPPPAESIENSILSLKEHGALTENEKLTNIGKTLARLPVDITIGKMLIMGSLFHQVEPVLSLAAALSVQSPFTNRAYRDLDCETSRKNLESDHGDPITLLNAYKEWLEIKHANSAEVRSGSSTSKKWCKRRGLEEQRFYEMTKLRTQFKDLLEDCKLLHTSDVNSEMSSSERIIRHGELKLLRSLKRSHKQNDTNKRKQLKIDDDNIRIEDDKEDEEIDIKDVEFRMRNDFSQVSNLVTASTACSYKDLTMLKLILCSGLYPQFASADEFNYCKTVSEQLFHTKVKPFVALHPMSFFGTHPQVLQLEEPDIVSIPGFKSKTPVSPKHQLLTYLSLLETTKPYLVNTLRIPAAQTLLLFAQEIDTNSTFTTLACDSWIALDFPTPDSGALLLLQAAKLRQKWDHLLNIQLQDSSSLENKLENIEELEHELSKGLVDFMHTSVPYTVKRLLAADLKRMYVGREENSTILKPNPFSSDYECQPHERKGGVRVTKQITFNCLVESEWSDRIACEMLEIDWECHTCNFRGALPSIEKLQHMSVCKRDNASEKNKSSALPVSKKKNAIAYECPDCQKTMYLLPTEVLKHRKQHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM67</accession>
    <name>A0A232EM67_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_013451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003411">
        <property type="protein sequence ID" value="OXU19455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM67"/>
    <dbReference type="STRING" id="543379.A0A232EM67"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012579193" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU19455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="389" mass="42559" checksum="514E8061D3A61A24" modified="2017-10-25" version="1">MNSRLLVAGLALLLCVGQARKSGPVLPLTESQIFRVELGGSVRMPCQFSNVDPDVAISWKRDDELLFLEETKFAGDPENRFSRLADNSLEISNANEADGRAKFVCSYLEEERGPNNPTIVHRIEIASAGSDDEGFILVTPSAMNEVEQGANLTLGCEGHRIKLDEETRHSIALRVSNATRHVAGDYQCLVEIGAARPLIKHLKLRVRRDPSQPVFRSGAAVDDSIELQWSVISYKPIVQAEVARLLGCSSRAKPPAKPCPLSRRFDLSSQVVYRKQAESAENWIAAKDVKVVSSLGKEHVLQGRIQGIAPGLYEARARARNDEEHADESQGLAWGPFSDLKKFNGEYKADADAASVRGSAAKPSVSSMTLLLLLLLLLVTSPLALRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMB8</accession>
    <name>A0A232EMB8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_012377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003386">
        <property type="protein sequence ID" value="OXU19496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMB8"/>
    <dbReference type="OrthoDB" id="7673081at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16430" checksum="33CF22956B5B98D5" modified="2017-10-25" version="1">MHETEERMNHNGHHQHHQHHLRSASSSTSRHSSSSSASSNGKGQHHNHSSSGSRMACEKASRKLRATLLKAARLGVSSSEIASLPAAKKIVSQRDHDWKLAVLLLLMFGGGVIVALVCTTSRGCSKLEDIVSRIPSFFPFLYSAGRTNEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMM6</accession>
    <name>A0A232EMM6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003328">
        <property type="protein sequence ID" value="OXU19613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMM6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="41" mass="4848" checksum="DA49FCAABDF048CA" modified="2017-10-25" version="1">MHDVVTRDEFKICSTVLKKRRDISKNCSLPFGYKKIIHPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232END9</accession>
    <name>A0A232END9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01003173">
        <property type="protein sequence ID" value="OXU19870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232END9"/>
    <dbReference type="STRING" id="543379.A0A232END9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="8">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU19870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="122" mass="14141" checksum="A1CD79195B2E8C76" modified="2017-10-25" version="1">MAQGDRSKRSTFIQQKSRCRENYKERASETTKPSEIRGKTSERKNPNSPLYRIESFESLNLKPELLRGFYDMGFNYSSKIQETLYYLICFVIHAIIYSPQNVIAQIQTSDTGRTAVFVLAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP90</accession>
    <name>A0A232EP90_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003005">
        <property type="protein sequence ID" value="OXU20137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP90"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="172" mass="19427" checksum="C34E4BE3CD71038A" modified="2017-10-25" version="1">MSASNKDKSVALFNVHLATVKLTQFYKVNVTLRLAHWKVDTSFINEHDPITATLDVQIPRHVPATHSYRNYKGICAEKLRDFLSALIWRELEDLGITTSKSPLPARFSLDARNKHFSFISNDPQASSVEEYLRTLKSLDQPEHFIFRAITESDVSAAVSHFNTQARGSDGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQH9</accession>
    <name>A0A232EQH9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002771">
        <property type="protein sequence ID" value="OXU20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQH9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6784" checksum="C2686BFBBBCEC0C8" modified="2017-10-25" version="1" fragment="single">RVTSEDRTLPSSAGVRPLRPRITSSYYRDFRIFSKDELSIAILVESRRLGGRQRHLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER07</accession>
    <name>A0A232ER07_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002676">
        <property type="protein sequence ID" value="OXU20800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER07"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8265" checksum="721FC24793E3F9C6" modified="2017-10-25" version="1">MVGHVSPPGGDRSKFGPLEESPSDIVKVRSHWFAYPKPLYQPLGSHGFRTERRRAAVWRNFAQLYTNKILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERH2</accession>
    <name>A0A232ERH2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002599">
        <property type="protein sequence ID" value="OXU20965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERH2"/>
    <dbReference type="OrthoDB" id="7654019at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="286" mass="31747" checksum="CBCB98C85D2EBB9B" modified="2017-10-25" version="1">MLLLFLLPNSVLAVVNPSPNPTPSSSSLSVLLPPTNHSASVQMNAAMMQQQQEKKMEPDWSPSLPDLTQMQQQQYSYTPAPPPPFMPANYYLPGNNHYGPAAPSTEFRASEHYAYPFEPQSYAYPVSAPPIDTALIPTAKHFVIVSFIGLLLLFAVIQNSIAAAKRKDALVEVLSNRRKRELVALDDMTPELESALKEDARVRCIQRTLCYENRKLLEDFGFVGKVLGKYLTRGVQSSLKELSPGWDRLVEDAANAGLRGEDCDVVYRDCNFVATPDEAAIDDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESP3</accession>
    <name>A0A232ESP3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002393">
        <property type="protein sequence ID" value="OXU21374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESP3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="6981" checksum="879B22092DEF8790" modified="2017-10-25" version="1">MTQLFVFCWFGNEVTVRILKVSYTAFNVLRDSTNLVLTDHSIHKNVRTTTSIRPDQTFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETM9</accession>
    <name>A0A232ETM9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_007250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002254">
        <property type="protein sequence ID" value="OXU21720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETM9"/>
    <dbReference type="STRING" id="543379.A0A232ETM9"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1960:FF:000001">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000044">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011968984" description="Peptidase A1 domain-containing protein" evidence="11">
        <location>
            <begin position="18"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="65"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU21720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="384" mass="41812" checksum="9DED8C2EEA5E17E4" modified="2017-10-25" version="1">MLRLVFLASLCLAFVTADVLRVPLYRVKSARRTLQEVGTELHQIKLRYGADPVPEPLSNYLDAQYYGEIGIGSPMQKFTVIFDTGSSNLWVPSKKCHITNIACLLHNKYDSRKSKSYKANGTEFSIRYGSGSLSGFLSTDVVTIAGVDVKDTTFAEAMSEPGLAFVAAKFDGILGMAYDRISVDGVPPVFYNMVKQNLVPQPIFSFYLNRDPNAKIGGEMILGGSDPAHYTGDFTYVPVSRKAYWQFKMDKISIGDKLFCENGCEAIADTGTSLIAGPVGEIEGINKKIGATPIVAGEAMVSCDAVPNLPTIDFVVGGKNFSLKGEEYVLKVAQFGKTICLSGFMGIDIPPPNGPLWILGDVFIGRFYTEFDMGNDRIGFANAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETP6</accession>
    <name>A0A232ETP6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002264">
        <property type="protein sequence ID" value="OXU21687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETP6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="61" mass="6851" checksum="9A9630E98BB98AEC" modified="2017-10-25" version="1">MLATISLESTLAENKLTVYYGWPTNLLKPSLCLTVYRWSGFLCFAWDDKNSGSLESFTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETU5</accession>
    <name>A0A232ETU5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_016840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002225">
        <property type="protein sequence ID" value="OXU21772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETU5"/>
    <dbReference type="STRING" id="543379.A0A232ETU5"/>
    <dbReference type="OrthoDB" id="10062932at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF4">
        <property type="entry name" value="GH03113P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="199"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU21772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38778" checksum="A0134A4651086E31" modified="2017-10-25" version="1">MGEEATMSCVSEGVPKPVLAWSFQGQELPILASGQRLRILANNRSLAGIYSCQASNGIGEPAKAAIELKIKPINPNPTIPSTITRHVASCDTIADKPEVTAVTRWLHSAPEIRARLECLVVAYPEARLDWYLENEKVVRSQRVLRYKQDTSLEDGSAAQLHSLVIRSVQPRDLGHYSCRASNELGQSEASLELSGVAKPPLLKKEIRSSSSNSYNFIWEVDSYSPIVEYQFWFRQMDSREDWRRLFIPSGNEGAGPVYARSFNLTGLQASRQYEALVLARNRFGWSSPSRIIRFATGQPSAVQVTSDSQRSESSSGVWGSHHRNDSFVLGLSVFVVLILARGKILLDGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUN2</accession>
    <name>A0A232EUN2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sensory neuron membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_003228</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002110">
        <property type="protein sequence ID" value="OXU22051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUN2"/>
    <dbReference type="STRING" id="543379.A0A232EUN2"/>
    <dbReference type="OrthoDB" id="10024078at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF69">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1124" mass="129304" checksum="FD8E4D65E31DA11B" modified="2017-10-25" version="1">MNKIKLTRSQKFGVYGLSLLLFSIVFGAIMLPSLKYYLMRWKVAIKLGWQMRYIWGKLPFGIDTKFYMFNLTNPDEVDNGAKPIMQEIGPYVYSEYAEKAFQEDHDEDDSVSYNARSYFYFNPEKTAPLTGYEEIIVPNYVGLGTMNIVVKERPGATNIVGRVTSNFLRLNFFLLRRYNPVKSVFFSYIGKAIDNILRKPNSLFEKKRVKDILFDGMPLDCTVKDFAGAAVCNELKSQYKDFGLILVEENQYILSLIGPRNGTDSPRTRVHRGIENLSKLTELIVYADKTNMSVWDDDYCDEFRGTEATLFRPFLDNKGKDDLDLVYSALCRSFTLSADGFGEWNGLKTIRYTTDLGTDGRANPKDRCYCDDPKNPDTCMKKGTFDAYKCVRLPLIFTNPHFYLADSSYLSQVDGLSPNKEKHMISIEIDPFTGIPLHTHTRAQFNLNIFKIDKFRLMNKFPEALLPILWIDQEMQLPAFLTEEIKIFHQFYAFGLTVQYLLMFSGLVLCGFSGFLMFKEHRKKKMEMKTTIPVKSDSQPNSADKKIHINTLQPATLPTSKAVDTLYLRNYNIRYLPAVILNSSIKSYKFFDMPLTKNQKIIVAGFCMFVFGILFQTAILPAVLRVQVKRQIALKDGWYMREIWGTFPFSMEFCFYFFNVTNPDEITNGEKPIVQEVGPFIYDKWHEKTNQKDHEEDDTVSYTVRNTYFFNSEKSKGLTGDEEVIVPHYFILGLILTVQRENPTAMPIVGKAIDSIFKKPKTIFMKAKIRDILFDGFVIDCNVQDFAGTAVCSEVADNYEKLGLKLVGEKKYLMSLWGPLNGTDSKGRMRVQRGIKNFMNVGTVVEYDNKLNISVWGDEYCDTFNGTDGTIFHPFFNKKGNDDLVAYNELLCRGISCHFVSKSKWKGFDTLRYTTDLGIDPENNPRHKCYCPSEDSCYRKGPYDIYKCLRAPIMITNPHFYLADPYYLTLVDGLSPDMEKHMLIIDLEPFTGAPVHAHTRGQFNMFINKTDKFKLMKKFPEALLPLMWFDEITILPDFLLKILRQGLLLYKIAKIYQYLMIFGGIALCSYGGYKHYKSTHVEDTKIVGELEKTDSFNEADNDNTSNKKSTSTTIQKIAVLPNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV63</accession>
    <name>A0A232EV63_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002041">
        <property type="protein sequence ID" value="OXU22246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EV63"/>
    <dbReference type="OrthoDB" id="10053386at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="16259" checksum="1BF16C822EE43688" modified="2017-10-25" version="1">MGVFECYGIIKFMLVFVNLVFWNKNHDFENWVLDVKENKNAIEIFGHRINPNHLSLRNKLKKLMVRVLYFIVMIELNLIDSIPTEFLNSLTPNGLPPHKLILKRETSRNKLFFSKESICEQDEDLLKDKKKLRKPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVB4</accession>
    <name>A0A232EVB4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002018">
        <property type="protein sequence ID" value="OXU22296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVB4"/>
    <dbReference type="STRING" id="543379.A0A232EVB4"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28056" checksum="7C8E1473AD6AD475" modified="2017-10-25" version="1">MLADVGFDVWLGNARGNTYSRKHVSLSPDYDEDFWNYSLAPAAIWHNRSNEITNFLLDHADTIRDIIKIGQIYELFPLTNSVVEFGRKICGNSSPYQKLCLKLQSLFVGDNLEQTNTSLVAHTLQYFPAGISAHTVDHYSQVVQSGHFKMFDYGIVKNFKIYKQKNPPLYNLSNIIAPIAIFYGNGDTLIPAENAVQLSKMLPNVLTIETVPDGKFNHLDFLFARDLKILLNDRLIEIIEAPLEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVC7</accession>
    <name>A0A232EVC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRC8 pannexin-like TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002011">
        <property type="protein sequence ID" value="OXU22312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVC7"/>
    <dbReference type="STRING" id="543379.A0A232EVC7"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF42">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 18-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU22312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38048" checksum="EC0E0F70A6085B49" modified="2017-10-25" version="1">MSVKMTLKDIKDKLDDDTLDLSLCDLEEVPVKEISTIKRFSHLDLSNNALVTLPKTFATLTQIIKLDLSKNMLTEIPENFGELKQLRHLDLYSNKISRLPLSLGELKNLKWLDLKENPLTPAVASIAGPCSNASECQACAKNIVTYLANVKTTINEEKQRRLTAVQEIEKTTASNKKEAKKKKKNAEKKAAEKEKSAIVKKEPPQEKNSVPKSPKSTKVDEHSSKRKDSNAGVFSLLCRAFTSLIMWSVFFAFLTITVLAVFPMYNEQQSEEIFKYVEVQTGVPLKHYHHEGIRLLESFIDKTKLWTNHTRELVEKTYQQYFLDESSTQPTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW50</accession>
    <name>A0A232EW50_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001910">
        <property type="protein sequence ID" value="OXU22589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW50"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="246" mass="27079" checksum="F1B8F5DEAFB31F5C" modified="2017-10-25" version="1">MPWQGMSGMLNEWSDPIAAWKEKSIDDSGSCGSDFESTKRYTKQSRKCTTKSQCSSELGFLLCLTKKKDRFICMVQFDDIRRKKVQEFSSTSCSASSSNSASSSAVASWYCWYSDTRSFMFDSASVNSISSIPSPVYQCKKAFLLNIAVNCSEIRLNNSWMAVLFPMKVADILRPRGGMYKPEASCDTGHCERYEMVEVTVCGCGELERSEADIVECLVVNAVGLVGVLDELVHGEGGVVGLDDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW87</accession>
    <name>A0A232EW87_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_010856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01001896">
        <property type="protein sequence ID" value="OXU22620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW87"/>
    <dbReference type="STRING" id="543379.A0A232EW87"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU22620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="282" mass="32881" checksum="A05FA373577F8C9E" modified="2017-10-25" version="1">MNSEDFEFIKKLNSGSFGSIYLVRRKEDDTEFVIKKQQRNYFDFAENEEATMSKLSHPNVIAFYGSWVDEEKHYILTENISGGTLYDLINEAYEEGRVPMEEQEALYFFAQLLLGLAHMHDRKIMHRDLKTENILFTEPLRRVKIIDFGLARDTTSEMDVTMVNPNNYTALENKSEEEPHTFKSDVWSIGVMLYEVATGVEPNDIEDDLEEKLADLPSAIKTICTRTLEFDPDKRPDCDEVLHYFELKESLCKYFDSLETTDRDIVYEQISDIVVDINEIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWI2</accession>
    <name>A0A232EWI2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_011328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001854">
        <property type="protein sequence ID" value="OXU22717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWI2"/>
    <dbReference type="STRING" id="543379.A0A232EWI2"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU22717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="208" mass="24088" checksum="6658EA9A514F5039" modified="2017-10-25" version="1">MEPAPLPLEPIKSNNIEERRLWVVSSLLLYLSNLIILFFNWYHFLKLVQKHGTIEKFDLLFHRSGPQAGQSRGYAFVTYKTARDAESAMETLQNLRVGSKNIVVRYAHSINEAELDKPKPKIEIPALAGAKKDDKKISRETAIQAIEAKLKMMKESEEEFQLNKPLEGTPLIYQYQKSESNKPSTSRHYGRGSYHNNRKPYSRTRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX29</accession>
    <name>A0A232EX29_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sialin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">H(+)/nitrate cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">H(+)/sialic acid cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Vesicular excitatory amino acid transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">TSAR_001140</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">Alberta</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitrate(out) + H(+)(out) = 2 nitrate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71539"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71540"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72591"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:72592"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-aspartate(out) = L-aspartate(in)</text>
            <dbReference type="Rhea" id="RHEA:66332"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-glutamate(out) = L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:66336"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)</text>
            <dbReference type="Rhea" id="RHEA:72599"/>
            <dbReference type="ChEBI" id="CHEBI:76931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:72600"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-acetylneuraminate(in) + H(+)(in) = N-acetylneuraminate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35418"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:28989"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001788">
        <property type="protein sequence ID" value="OXU22922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX29"/>
    <dbReference type="STRING" id="543379.A0A232EX29"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000067">
        <property type="entry name" value="sialin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="28">
        <location>
            <begin position="17"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00056891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00081195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OXU22922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="495" mass="54449" checksum="28AAB9F712C28C8C" modified="2017-10-25" version="1">MITSLKHCCAPIPQRWIFAFMSFLALVMAYGMRVSISITITEMVKHIEKNVTIDEETCPKDENSAPKNTTGTGAGTYDWDEETQGIILSSFYWGYVITQLPGALLAEKFGGKQTLGLGMLCTAILTIAIPFAVTWGESTALIVLRVLMGLGEGVTLPALNVMLAQWVPPDERSKTGSFVYVGAPLGTVFATAISGVILKYTSWPIVFYFFGGIGIVWYFIWLVTCYNTPREHPFISDKEATFLHQELSAVAHVNPPPVPWRHLLKSMPLWALISVQIGHDWGFYTISTELPKYMSSVLHYSVDQNGYLSSLPYIGMWLCCTFMSWLADWLISKGHMAITTVRKVGTTIASVGPGLFVIAASYVGCDRTLVVVMFTLGVTLLGSGIPSLKVNALDLSPNYAGTVMAISNGAAACTGIITPYLTGVLTPDQTLSQWRVVFWIIFVVLMVSNVFYLIFASGKVADWNDPILMKRNKAEQKRAQEAAAFEASRKATEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX62</accession>
    <name>A0A232EX62_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large subunit GTPase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001770">
        <property type="protein sequence ID" value="OXU22964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX62"/>
    <dbReference type="STRING" id="543379.A0A232EX62"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="163"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="676" mass="77275" checksum="84A81EBD9A30F6AA" modified="2017-10-25" version="1">MSKKNSKQGIGRALIKDRFGPRKNHKRDGEDFLHTVDMQDGYDWGRLNLQSVTEESSFQEFLATAELADMDFQAEKLNIKFISTKNNIDLPSKEEQEGILKLHEENKGLLKIPRRPKWDKSTTSHELQTKEKEEFLEWRKRLSILQEKENILMTPYEKNLEFWRQLWRVIERSDVIVQIVDARNPLLFRCEDLEQYVKEVDPNKLNMILINKADFLTPEQRVIWAEYFDKINVKVAFFSATLEAEKENDDTIPEEEEQQAAEEEEEEEEEDQNTEPESDQESAYSSDALKEDSDQKKDDDSIVNTETKAEFPASEQSSDNNKSTAAVLTKTENPEAEKSLNRNSKENNEVDKNAETNTENPELVKNLDDISLNHNKLNSSNLLSRDELIELFRTTRPAKTCKNNITTIGLVGYPNVGKSSTINALLTHKKVSVSTTPGKTKHFQTIFLDSDLMLCDCPGLVMPSFVSTKAEMVLNGILPVNQLRDHVAPITVLGSLIPRHILEEKYGIMIPLPEVGEDPDRTPTSEEILNAHGYNRGFMTQNGQPDNARSARYILKDFICGKLLFCKAPPDYNQDEFHKFPVTEKKPHTSSNVPLNKPVTRKTDDLDKKFFQTPAVGVHKKGKKLILNSTSSDSASIMGSQTSLCSVDKPWKAQNKHGNKKKREKLRRVYAHLDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXD8</accession>
    <name>A0A232EXD8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Glycyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_005791</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:34936"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>tRNA(Gly) + glycine + ATP = glycyl-tRNA(Gly) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16014"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001740">
        <property type="protein sequence ID" value="OXU23066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXD8"/>
    <dbReference type="STRING" id="543379.A0A232EXD8"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00762">
        <property type="entry name" value="WHEP_TRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="20">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="19">
        <location>
            <begin position="334"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU23066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="816" mass="92452" checksum="DB702A47C1E0AA32" modified="2017-10-25" version="1">MIPRPIPETHQERIYGRETEFGGSFSLTEGLLPARRGCMMMPREVPPRAVCINATEITSRMRVLLGCSWRLGRSLLRSVQQQQTPVLTARLKSHAAVAPVVWGSKKKHRKVKLNVFLDMADPKIEAELAPLRASVKEQRDLTFTVAHWLWSDSLFSRGDRVRKLKADGAPELDIKKAVAELKLRKKVLEDKELSLVPDAATFDRARMEDLLKRRFFYDQSFAIYGGITGQYDFGPMGCAFKANLLSAWRNFFVLEEQMLEVDCSILTPEPVLKASGHVERFADLMVKDVKNGECFRLDHLIKAHLEKVCADKKTTEETKKECEDIVIRLDGMTKEEMGAVLKKFNMKSPITQNDLTEPIEFNLMFGTQIGPTGLIKGFLRPETAQGIFVNFKRLLEFNQEKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFCDPSDKSHHKFDSVKDTNMLLYSACNQMDGKSAEYLTIGKAVESGLVANETLGYFMARIQKFLVKVGVDPKKLRFRQHMGNEMAHYACDCWDAELLTSYGWVECVGCADRSAYDLTQHTKATGVKLVAEKKLPQPKTIDVCEAAPNRGLIGKTFRKEAKVILDALAALEEKDIDALEKDLNEKGEYELQTSDAPYKITKDMITIKRYQKTVHVEEFVPSVIEPSFGIGRIMYSVFEHNFKMRDGDEQRRYFSLPPVVAPLKCSVLPLSSNAEFTPFVKKLSQELTRVDVSHKVDDSSGSIGRRYARTDEIAIPFGITIDFDTLKEPHSATLRERDSMGQVRINLEELPAVVRDLSLGKITWSDVEAKYPKFEQQESTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXM3</accession>
    <name>A0A232EXM3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit beta</fullName>
            <ecNumber evidence="12">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_011599</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01001745">
        <property type="protein sequence ID" value="OXU23047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXM3"/>
    <dbReference type="STRING" id="543379.A0A232EXM3"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="190"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU23047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="518" mass="55313" checksum="4420B4DA08FCE586" modified="2017-10-25" version="1">MMLSAVSKAAAGALRAVKPTLLQQESAKIAGVLSVNSREYAAKPAAAGKVAQGKVVAVIGAVVDVQFDDELPPILNALEVQDRSPRLVLEIAQHLGENTVRTIAMDGTEGLVRGQNVLDTGFPIRIPVGAETLGRIINVIGEPIDERGPIPTDKLASIHADAPEFVDMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYQEMIESGVISLKDKTSKVSLVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIIGAEHYNIARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVARARKIQRFLSQPFQVAEVFTGHPGKLVPLAETIKGFQKILNGELDHLPEVAFYMVGPIEEVAAKAESLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXP3</accession>
    <name>A0A232EXP3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="4 13">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_012764</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="4 13"/>
    <dbReference type="EMBL" id="NNAY01001723">
        <property type="protein sequence ID" value="OXU23123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXP3"/>
    <dbReference type="STRING" id="543379.A0A232EXP3"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU23123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="286" mass="33025" checksum="3CB206AF903FDC21" modified="2017-10-25" version="1">MKHFYEQIGLFSFFSSLVTNILFNQLLLYLLKYCYNSILQTYWIQLVTYGFSIIIIKIIYRSPFYEISSRANFLGFCLSLGILICNSSIYIWKTFGIYVTVLSTFHFTEFLGIAFTNPASLSFDSFVINHSPAYTLAAIASWTEFGTRVYFFPNMKPNLCLLVIGTIFCVAGEILRKTAIFTAKQNFNHIVQSKKSNHHSLVTHGVYNVCRHPSYVGWFYWSIGTQLILHNPICLLAYIIISWKFFEDRIFIEELSLVEFYGDAYKIYQNNVGTGLPFISGYIDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY78</accession>
    <name>A0A232EY78_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB10 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001707">
        <property type="protein sequence ID" value="OXU23168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY78"/>
    <dbReference type="STRING" id="543379.A0A232EY78"/>
    <dbReference type="OrthoDB" id="6017729at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019377">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10249">
        <property type="entry name" value="NDUFB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="167" mass="20135" checksum="974E45AD7B8DA97D" modified="2017-10-25" version="1">MVEPQARSPINRLMLKLYNILDVPVTFFREKIVEPNQKSYPYYHQKYRRVPTIDTCYTDDYVCRYEANQQFLRDRQVDSQILSILRERHNHCVHEDYNQREEAKCKAIYEVYEENAANWFAKYGDLGPSPDVVHAFMKQKHRMIWERRHGPIGSGMKEDPYKIKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZB3</accession>
    <name>A0A232EZB3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Agenet-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_010572</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001537">
        <property type="protein sequence ID" value="OXU23659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZB3"/>
    <dbReference type="STRING" id="543379.A0A232EZB3"/>
    <dbReference type="OrthoDB" id="424249at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048170">
        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099577">
        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22425">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22427">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20402">
        <property type="entry name" value="Tudor_Agenet_FMRP-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000002">
        <property type="entry name" value="Fragile X mental retardation 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000004">
        <property type="entry name" value="Fragile X mental retardation 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000054">
        <property type="entry name" value="Fragile X mental retardation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022034">
        <property type="entry name" value="FMR1-like_C_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040472">
        <property type="entry name" value="FMRP_KH0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041560">
        <property type="entry name" value="Tudor_FRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12235">
        <property type="entry name" value="FXMRP1_C_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17904">
        <property type="entry name" value="KH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18336">
        <property type="entry name" value="Tudor_FRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51641">
        <property type="entry name" value="AGENET_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Agenet-like" evidence="17">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Agenet-like" evidence="17">
        <location>
            <begin position="63"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="409"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="564"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU23659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="659" mass="74103" checksum="19FD5F587F88296B" modified="2017-10-25" version="1">MEDLAVEVCGENGAYYKAFVRDVFDEEVLVAFENDWQPESKFPFSKVRLPPKDGPKPEFQENQEIEVFSRANDQEASGWWRAIINMTKGGFQVIEYLGWDCAYTEIVASERLRPKNPNPPIDKNTFHKIEIEVPEDLREFAKMDNVHKEFQKVIGASVCRYVPERGVLLAISRHENMRRHCSMLQEMHFRNLQQKVLLLKRTEEAARQLESSTKLQTVGVKFRPSNFVYQRVSDFETGVRTNSRYTDEFNVREDLMGLAIGSHGANIQQARKVEGITNIELEENSCTFKIYGETHDAVKKARSMLEYSEESIQVPRILVGKVIGKNGRIIQEIVDKSGVVRVKIEGDNEPQPTIPREEGQVPFVFVGTVESISNAKVLLEYHLAHLKEVEQLRQEKLEIDQKLRNIHGPITGSMHNFQPARRGMPMGVEESSSSRGGRGGQTRGRGRGRAPPRHNSGMRRDTMDSNEDRIRDLPPRGGHQGGQGGGSGYGGRQGGGGGGGGRPNTQRRDRRDDRRRTTDDEDTVLDSQDVSSIDREISPLVCQFCVIREHMVTMVCIYVDSVSSVEGGSRGSKRRLRRYRQRSATPSNSRRGSSASQVDQSVGPSVVSKEVTPSNNDISPPTNSNNQQGPKGQREQRGRYPRVPQNSKPKEAMVNGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZE3</accession>
    <name>A0A232EZE3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001527">
        <property type="protein sequence ID" value="OXU23677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZE3"/>
    <dbReference type="STRING" id="543379.A0A232EZE3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU23677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10650" checksum="4464D9BBB6717ABD" modified="2017-10-25" version="1">MYGKRWQEAKDQRESRGETRDEEAVQVRQCLHQVSQAQQAGINNSDGFLDLVELKRMIEVLGAPQTHLGFKDMIQKVDENGDRRISPGVSANLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZH0</accession>
    <name>A0A232EZH0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear cap-binding protein subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">80 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_016033</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the nuclear cap-binding complex (CBC), a heterodimer composed of Cbp80 and Cbp20 that interacts with m7GpppG-capped RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001524">
        <property type="protein sequence ID" value="OXU23693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZH0"/>
    <dbReference type="STRING" id="543379.A0A232EZH0"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000010">
        <property type="entry name" value="Nuclear cap-binding protein subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000041">
        <property type="entry name" value="Nuclear cap-binding protein subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="MIF4G" evidence="12">
        <location>
            <begin position="30"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="666"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU23693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="793" mass="92552" checksum="159FBE7E72FBD790" modified="2017-10-25" version="1">MSRRRGHDDDDGYDRVYKKRRRVSENQEIEDRLESLILRVGEKSTSSLESNLEGLASVLEADLGLFRNKILRILTDCAIKMPEKCTIYTTLVGLLNAKNFNFGGEFVDYMVKHFKDALKAGKWDVARYSLRFLADLVNCHVLSCGSLMQLFDNMLDASNEDSVPQVRRDWYVYAVLSTLPWVGRELYEKKEQELDHLMVTIEVFLNKRSKKHQPALRVWSSDTPHPQEEYLDCLWAQVRKLRQDNWAEKHIPRPYLAFDSILCEALQHNLPVLIPPPHHDSYVYPLPTVVFRMFDYTDCPAEGPLLPGSHAIERYLIEEHLRQIIDTYYLERKDCAAQLLNFPYKTKIPLDYCIVEVMFGELFKLPTPKHLEVCYGSILIELCKLQPSTMPQVLAQATEILFRRIDSMAATAFDRFVWWFSYHLSNFQFRWSWEDWDSCLLRDAEHPRPKFIREVLLKSLRLSYYQRIRDMMPESYAELLPAVPEPIYKYSSEGASSLPGTTVAHELVVAIRRKCTPEEALNVLNSLPGPGENEENYSFNPLKIDVFVQTLLNLGSKSFSHSFAAIGKFHYVFKVLAETEEAQICILRNMYALWKNHYQMMVVLTDKFLKTGIIECSAIANWIFSKEMASEFTKLYIWEILHLTIRKKNKHVIKLSKELTEAREKLRRAESRSGSSSDDDDKDKGERPSEDAVERMEEKLEAAQADQKNLFLIIFQRFIMILSEHLVKCDTDGIDYNTHWYKWTIGRLQQVFLTHHEQVQKYSSTLETLLFTPDLDSHILDVFHQFDLLLTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F031</accession>
    <name>A0A232F031_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_001445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001435">
        <property type="protein sequence ID" value="OXU23985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F031"/>
    <dbReference type="STRING" id="543379.A0A232F031"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397">
        <property type="entry name" value="CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21397:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013031381" description="ER membrane protein complex subunit 10" evidence="9">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU23985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="231" mass="25080" checksum="4F07EE73456FE487" modified="2017-10-25" version="1">MYLTYGTVLTFLSLFSFISASELDYDGWLQVRLYHSFDDLPVPQYTERGNVTISSIRSGAAIVAQPSISNANVDKLSKLAENGSKYRLKAVVKTSSGSETTFLSSVLACNLVGSNLQDTLYIWLDSTAQPVAVNLMSRGPCSQDSPATQMWTTEVQVKYPDGGPIPDTATYIQKIEREKQARESGEVKDNRSFFAKYWMYIVPALIFFVLTSATNPEAGGAGGGGGGGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0D3</accession>
    <name>A0A232F0D3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001437">
        <property type="protein sequence ID" value="OXU23977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0D3"/>
    <dbReference type="STRING" id="543379.A0A232F0D3"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU23977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="505" mass="55538" checksum="BD197975F0C6EF88" modified="2017-10-25" version="1">MSTPRHTTATRSSIATAPVRKCSSLFLSSTDFRERGTAAFEISLWSIIICKNFRQDPITMTAKTSSPVRTKEADRTDDSKTIRVVFISLLLDLLAFTMILPLFPALLDHYQSIDNGKGLYSIVLNKIHKLSSLLNAPDNVNTVLFGGFLGSLYSFLQFLGSPIIGALSDVYGRKPLMILCLTGIALSYLLWALSSNFGLFILARVLGGISKGNVNLSMAIISDVTSPASRGRAMALVGIAFSVGFVLGPMIGAMFAKMSTGSREGQWYALPAMFAFFLSMCDLFYVAMHMKESLPIHRRAKSLVHGISGALTYINPSDLFQFNGVTGLTPSELQRLRSLGRTYFLYLFIYSGLEFTLTFLTHYSFGFTRMQQGWMFLGIGTTMAILQGSWIRRIPEHKTKAITELFVRLNYLIKRITLYIVNLKNMFFNAATAMVVTCIMTLVTRVGPENQKGIITGIFRSLGALARASGPIIASIAFWSLGSSTSYLIGAVALVVPPLILRNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F187</accession>
    <name>A0A232F187_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL16m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_015521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001293">
        <property type="protein sequence ID" value="OXU24461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F187"/>
    <dbReference type="STRING" id="543379.A0A232F187"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU24461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="291" mass="33513" checksum="201CF3D1E4D1785F" modified="2017-10-25" version="1">MFSRSLLCSTRLSVLPPCNNVFGTTIQAAGLKHFPPPIKYDIETPPDTRGKKLSIQPKVPQYPPQMRPFKMQKKLRFMRGPELVLNKLLHKQYGVILSIQPKVPQYPPQMRPFKMQKKLRFMRGPELVLNKLLHKQYGVIALVGGRMKYGHFEMVRWTCGRKLPEKAFSLWRVDAPWQPITKKGIGQRMGGGKGSIDHYVTPVKAGRVIIEVGGPVEYAQVKKTLEEVAHKLPFPAMAVSQEILDQMEDDERYKEEYNENPYTMKYIIQNNLGGCHKWISPVDKLYFGKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1B2</accession>
    <name>A0A232F1B2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001331">
        <property type="protein sequence ID" value="OXU24333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1B2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="498" mass="56924" checksum="D6D17743A59CBA3B" modified="2017-10-25" version="1">MINCKVSSSTLQSNESVVAAGDNESKNYSTFDVVLSQFERFHVDSQQAKHSTCKKENCSELDTTVEDLAVSISSMDFAKKETLEIRAFKTLKSDSYALHKLHDEKCSTSPHEHRRRATVGQHRNHRHWSRFCSIKNVRIYFSQLKINESAALSDDSSVIFVSDMSVSDVESVNLDDGDVILNEDDKESVDNEMQVVTETVTTTEIITKTEETILKVDKSTQTYENEFHVQSVASPGILALPSTTSTPKKKINVLSVSAVNCLNISAARDPTLSQKSTSNIQSTIVPYVSLVNIRKNTAIDSINKLNATNNNENTDKNGFASTSGKSNNLNTVDKKKNNDKKDMATTSNKSKNSNAVNDKENRGKHDTAYNSKDDKNSQGSVRRTWTKSRSYQNHRVQPYQRYNNYYSGRQNDYDRYGGRRNDYNDYNSYGYRGRYRSEYQNNNRYNSNSYGYGAPYNSYNPQRGWQVQHYTYQFKERLFTGFVRFMDFVFQYDYTGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1H2</accession>
    <name>A0A232F1H2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001313">
        <property type="protein sequence ID" value="OXU24392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1H2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="121" mass="13995" checksum="B91E960C08849BA9" modified="2017-10-25" version="1">MAAKKRGVALGGYTERVEEELDKDEEEKSEEHYRRRMQQQLQQVVVAAHFLPAAMTTRTQPRTVRRKVGKELNQRVSDSRAVIFSTYKHAQNAQQVNLYVEIKNEDNTVFMDATVSVQPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1N3</accession>
    <name>A0A232F1N3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001243">
        <property type="protein sequence ID" value="OXU24625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1N3"/>
    <dbReference type="STRING" id="543379.A0A232F1N3"/>
    <dbReference type="OrthoDB" id="6767540at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="194" mass="21179" checksum="B217D2664704943B" modified="2017-10-25" version="1">MSFFGWGKSGRDANTDHTGRNLQDGLFQIASQACHILVQVNNTHNVSYGGSNRVTNVAYSKYSGGEGSTSLSSPATSPPSAPASGVYTKNVGTDPLLKDQDVVVLLPQRKSRTPRIRHKLARTIAVCIISKVEQSGFDDDEDTWKSSVRQRIIRAPINAVAAQKNPFEFVNAAIRVIDGKVASRLYLFSLYSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2N1</accession>
    <name>A0A232F2N1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS12m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_007243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001231">
        <property type="protein sequence ID" value="OXU24677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2N1"/>
    <dbReference type="STRING" id="543379.A0A232F2N1"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000115">
        <property type="entry name" value="28S ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013302839" description="Small ribosomal subunit protein uS12m" evidence="8">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="309" mass="32904" checksum="094EB3E4E756DFE4" modified="2017-10-25" version="1">MKTIILIAIIAAVASPIYAEEALEPKKQEKRGLLGLGYGGYYSGLGVHGLGGYGGYGHLASPSVVSHGVLPTYSHASYGGHLGGYHSAAPVYSAPLRLGAYSHGVGLGHAGLGLGHGYNGYLGHNVCIGVNNRAGTMNIIARTIGNLAKTCLGRTVEGNSLALARQNFSGFPAANGSILAEARKYLENSMLGLQQIREKNILLKMHERGPIIKKRKSKNPFNGAPFAKGVVLKTLIKKPKKPNSANRKCVLVRLSNGKEMTAYVPGIGHNLQEHNIVLCRVGRCRDVPGVKIKCIRGKYDLAHVVKNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2W3</accession>
    <name>A0A232F2W3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_012500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01001198">
        <property type="protein sequence ID" value="OXU24767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2W3"/>
    <dbReference type="STRING" id="543379.A0A232F2W3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="74"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="346"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU24767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="512" mass="58724" checksum="D55DE282B1E79726" modified="2017-10-25" version="1">MADNDDLLDYEDEEQTEQIVEGNGEVAPAKKEVKGTYVSIHSSGFRDFLLKPEILRAIVDCGFEHPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLESTENHVYVLVMCHTRELAFQISKEYERFSKYMQNVKVSVFFGGLPIQKDEEVLKNTCPHIVVGTPGRILALIKSKKLNLKHLKHFVLDECDKMLEQLDMRKDVQEIFRSTPHGKQVMMFSATLSKEIRPVCKKFMQDVRCDDFTMISNSVLAYKYRLENIRGVGAQDILKKEEFKKEDSRGLPGDLINFEIPFVGSEKNCVSRSVTVNIPLLEYTRHGRHLAYDPMEVYVDDEAKLTLHGLQQHYIKLKENEKNKKLFELLDVLEFNQVVIFVKSVQRCMALAQLLTEQNFPAIGIHRGMTQEERLTKYQSFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPENSDTYLHRVARAGRFGTKGLAITFISDESDAKILNDVQERFDVNITELPDEIDLASYIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F361</accession>
    <name>A0A232F361_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MFAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001170">
        <property type="protein sequence ID" value="OXU24893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F361"/>
    <dbReference type="STRING" id="543379.A0A232F361"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="4">
        <location>
            <begin position="204"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="456" mass="53832" checksum="5DEE0F32D6C84A2C" modified="2017-10-25" version="1">MDYFVANSSLAPAPMGIQSTAGAVPIKNDKGEVSMKKVKVHRYVSGKRPDYAPDASTDGESEEDDFLDKRPYQEENVSEIREDEEQIKTREIDDPRLRRLTRVDRLRENDDDIRVERRRHIQEPEVLVADINEKSRERIKLDSSESSEDEELSDEEIERRREALKQRVLSKKEAEEELVKEEDEEEKSGDSSESSSEYEEYTDSEEETGPRLKPVFVRKRDRITVMEKEKEAQKQKQAEMEAKKLVEERKKQTLRMVEESIRKESQVRSSQYETEGNINDVVTDDENDELVYESWKLRELKRNKRDREEREAVERERLEIERLRNMTEEERRQEARLNPKVVTNKAAKGKYKFLQKYYHRGAFYLDKDDTIYKRDFSGATLEDHFDKTVLPKVMQVKNFGRSGRTKYTHLVDQDTTQFDSPWISETAQNLKFHNNQAAGVKQVFDRPSLKKRKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F382</accession>
    <name>A0A232F382_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001128">
        <property type="protein sequence ID" value="OXU25042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F382"/>
    <dbReference type="STRING" id="543379.A0A232F382"/>
    <dbReference type="OrthoDB" id="6263678at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029357">
        <property type="entry name" value="SPATA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14917:SF4">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14917">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15244">
        <property type="entry name" value="HSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="625" mass="70715" checksum="E18E493F5ECA0146" modified="2017-10-25" version="1" fragment="single">DTSCPCARPSTAKDRPKSSLKSRKRLDEINQFCGSKSCLSTARSRKCKYEAKQERRPSSSSRGEISQKQQSETEESLGKLQAGEEEEARYAKFVYDITQEIVQNGLYTDRELKQVFEKHLERSSGRLNKRKMLYEIYQLKISLNMMDDSEEEDEVEADLVYAEKFASQRVPKPPTPPKVLNENKVIEKLQSFRELQENNVELYNNSAASSPRNKSVVLVDANPEFLVTERDVLSTLMDNHVEPEQIQRIYRKLFQRSKDMSLYEARRNFVQSTLLAVSQVQVGSEVAYAHRLRVDRSTSAASLSSAYHKERSHGILRKESTDFDAPRFGYPKNKQNEALEKCSRWRIEHRCDCKTQPCELEHEAEKSARKKDSSNRKINFTESDNSRRSGKEAKSSPETSARSSAAPGEKPDSARSEEPEEIEEDIESVIDELPDNKSPVADKSDHEEKELSSVQAASSDESLEYSDDFSNASENSKSPKGKVGNRRYSSIREYFERFATIDDQKIWRISEGSSSSSSSTSAVAPDYLQQSSAAGKVIKKRTSSGMSGFKVMDSWNERLSELSSDFYVNSAAGAKCDERCRRVSGKSCGDSCKFVRTDCRNLGRTSGCLNRLDEKPNRRGSDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3N9</accession>
    <name>A0A232F3N9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G protein pathway suppressor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001084">
        <property type="protein sequence ID" value="OXU25202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3N9"/>
    <dbReference type="STRING" id="543379.A0A232F3N9"/>
    <dbReference type="OrthoDB" id="10038194at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026094">
        <property type="entry name" value="GPS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22654">
        <property type="entry name" value="G PROTEIN PATHWAY SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22654:SF2">
        <property type="entry name" value="G PROTEIN PATHWAY SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15991">
        <property type="entry name" value="G_path_suppress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39041" checksum="ECCBEBEEBAC4978F" modified="2017-10-25" version="1">MPAVVPGTAPQRNEQMWKALKIHILRERQRKKQEQEADAEEERQRKERETQQKQNVMTLEETREQINTLENELTQLKNEKHQLFVQLKKVLHEDDNRRRLIKETIISLEPMPINGYIDPGAVVHPHLYLPLPTSSPLYKVSAATPPHTLMSSQGPLKRSHSPTPPPPPPVSSYHPGYGYKPPLSIASYIPTPSKSEDAARRSGDARVVLWNKSPNQFPGSSYYGPTPTQYDFGPPPTSQPLPRVPEPGKPVYLTATRAPIPTIQTTPYAEDKFYPRPGSHVAVHGGAIPIQQPPQGAKTGGITTGYPVRAPQPPQGPYPPPPPGTYVSVAGGSVPGRLLYTQPQPRYLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3P6</accession>
    <name>A0A232F3P6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001040">
        <property type="protein sequence ID" value="OXU25384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3P6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="7546" checksum="C5AD354D220F7C4D" modified="2017-10-25" version="1">MRPLIKLVYCGDGNSNCYQSVTKTQPHPKSPKRKPILLTSTTTNISGTAPPPPPPPPAARSHQATSHFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F418</accession>
    <name>A0A232F418_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001101">
        <property type="protein sequence ID" value="OXU25137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F418"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="22" mass="2521" checksum="1BFD8D973FA07E66" modified="2017-10-25" version="1">MSNGLLEKMTIHSFRCKLSIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4A9</accession>
    <name>A0A232F4A9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001059">
        <property type="protein sequence ID" value="OXU25308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F4A9"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="918"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1159"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1243"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1351" mass="156291" checksum="20865C9C95B15ADA" modified="2017-10-25" version="1">MATINDAFTEGHRYTRSIAAKFYKKMDIDVDNTLPLTNNGPNNNNKEQFCLQEEIIDLHESEGSDIEIVAVSKSVAEGRTKNKLKAFIRSRRKTKIYVNSDGDIPNQLKTFNRSIDRCNFKGLQNTPKRKVPNRNESLSSIILNCPRCNITKTVFSTTLGNITCKECSVNMTYVCNKCNLRYPTMLALYRHKKLQCERTVKAKTLQPKTMFILKCSRCNLSQKIQRIKLSKCLSCCIDMHYECVVCGKNFNTYSNLYTHMKRRCQPKCRTYYCNECSFNCTCESILVRHLNKHHPGLFVLDNTVKCCVCNETFEDVMHLKQHEVGCGSSYYQCKFCVYKPKYQENLRKHLLTRHADKVRGEDLQEVLRQSVYRPKLVRKLKEKVIKGIRMKVPEEPNKIRDEISITAKTVYCPKCDLDSEYKKGIRYCPTCNTSFSYRCSECSGTYRGLPSLYRHFHRQHGNMHYECENCGRCFSFFGDVNEHRKTCGQEPRFECEICFFKTRYKYNLRNHMFKIHNENRKNFVCQDCGMQYKTARTMKKHMDRCEKRIIRMTVMVIPDKVSNSNRDFLNGDVCTDSSNDSDIEVISSSIKEKKNTAKSITASAKYLKTILKGSKAKLKNVASVLKETKTESRSITSFLVPEQSKPLLMLTNHTVSRDKITDDDAGILVENLPDSEKSPIFCKSFDNNENLLHKIGKNTSRDFFQPKDQINNTLEFEEDVNVVIPQSIEETESNIMLKQFKNKFKVTKQSNTLMTLRNDTDLKEQTIDDETGISFEDLVDLADDENLPCINDKLMDDENALNKKVKDISKNCLSPAKISNCYVDPDDVLHGISDDSISNSDSYQKGFVDSLPPKGDPSIINNAPLNITSVGNTLLSTDDTESLNSLVRLKCTNCLTLVQCPEVEPQMECQKCCLKYQYQCKICTSGFVSLYSLYTHLIKFHSRGEAVHSLMIKPQYVKKPRQVKRLQCDSTEIYNCQKCGSVFKLETIKNKHEAICSRNPKLNCPFCSLAMSFKKNLKEHMIKFHSESFEMNEVDGIINQIVKDGNKKRRDEKATSLLQMLQVASCRKCDRRTPVHELLNGQMKCAICSENFVFTCADPECSRIFPTAKALSLHARMLHIEKRDHYRCAHCLYATTSSRDLIRHQKDCGDLVILPPRLFVCPNCDKSFKKERYLQVHLQRPETCARNKQRELVCPKCNRTFRMQHWLQNHRCESVTTTLELSEPTLPMELSSTELVPLQEPEYPCPDCGKVFKQMRWFNAHKEKYCYKQRVLYRCAHCRYQGFEKKKLKVHIRCAHIHLCTGKKLRCVKCGTKWTSIYSLNRHLDNCSGDYETERLYYKTVTKLGKFETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5K2</accession>
    <name>A0A232F5K2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nuclear receptor subfamily 2 group E member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_016082</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000951">
        <property type="protein sequence ID" value="OXU25759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5K2"/>
    <dbReference type="STRING" id="543379.A0A232F5K2"/>
    <dbReference type="OrthoDB" id="10045640at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07163">
        <property type="entry name" value="NR_DBD_TLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06930">
        <property type="entry name" value="NR_LBD_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000019">
        <property type="entry name" value="Nuclear receptor subfamily 2 group E member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="214"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU25759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51952" checksum="5130207D86874C0E" modified="2017-10-25" version="1">MMLRPDTRMGHISHSPVEKIEAHPMTQPQPPSSSRILHDVPCRVCQDHSSGKHYGIYACDGCAGFFKRSIRRNRQYICKAKGENLCVVDKTHRNQCRACRLAKCIEAGMNRDAVQHERGPRNSTLRRQMALYYTNKESEILTSSLTNGLANGLASGIVGNIATSLSNSIVNPHGNGYTPPPQLNTALDLVLPKSASTGPSRVSVSHRHLHHSLYSSPHLSKVTDISSPYLHHPRHHHHHHSPPPQILHPLPTIRLPLFIMETMCEQAANIFLLNIAWAREVNSITGICLEDQLTLVENSWRDLFVLSAAQYAPTMDPTSLIPPGPNSLAMSIEVSRFREVLMSLHTMALDSQEYACIRSVVLYKAGLENSEIVPSSRSSDGSMSPVCSKLRDVHSIMKLKDAAQAALCTKVDVSNAVGAVKYSKIVLLIPMLKHISAHSIEELFFRKTIGESPMERIICDVYLRRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5Q5</accession>
    <name>A0A232F5Q5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000866">
        <property type="protein sequence ID" value="OXU26144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5Q5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU26144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="114" mass="13038" checksum="198543F3344BE9B8" modified="2017-10-25" version="1" fragment="single">TEELGRYVIQDEKDVRLLTFVEIALPRVYKTVAARIAQDSGFDGANEKVDKKQRPSENAVITCTTSETYQRWTAKYLSTKGSVRTQSHRGLQSFVRHATSCVREILKPSRTRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5V3</accession>
    <name>A0A232F5V3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000843">
        <property type="protein sequence ID" value="OXU26236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5V3"/>
    <dbReference type="STRING" id="543379.A0A232F5V3"/>
    <dbReference type="OrthoDB" id="6577359at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="134" mass="15420" checksum="73082E45BB2109B2" modified="2017-10-25" version="1">MDSFNQLMIAMGVYHQGIDFIRELPVELSQIILSKLDTHSFLNAAQVSRKWLAVSKSTSSFRKRARRHIRRRNQRLAQVLPPPPSKQSTTRILSKPIMSIPQTKIPYPTFLNTKPLNVKNSTTKSTQPRKVIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F604</accession>
    <name>A0A232F604_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_011322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000901">
        <property type="protein sequence ID" value="OXU26012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F604"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="346" mass="39783" checksum="544758F5E9162C63" modified="2017-10-25" version="1">MILTLVINGMRTWCGRNMDLVLCGENFEGVLYLGVVTLKYYVTILSEPRIMQIHKQIAKNWSTLTNSEEQSILIKHSKQGKIVTILYLVYLYAAGFAFSQVSMVPVILDYIWPLNESRPKILIVHAEYIIDPLQYYFELYGAYCILTFINLTVLISIDTAFSSIVYQNLGVFSIVKNRLNAVTKRPNEKKDNAYEFIVGAIRLHNSALQFNDLIEMSYRKTFLIILGYTILFLSVGGVILIEQTNIMQFIRLAMIEVGVMIHLLYLSYPGQKVLDYSSSIYQESYTNEWYLISKKSKILLKFMMLRCIKPSVLTAGGLYIMNYENYGIVMANVTLVPVIRYNNAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F616</accession>
    <name>A0A232F616_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000836">
        <property type="protein sequence ID" value="OXU26261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F616"/>
    <dbReference type="STRING" id="543379.A0A232F616"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF72">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="484" mass="55200" checksum="3F7953CD39392027" modified="2017-10-25" version="1">MMSDVNRTESFLTTIKKALRTEDNGAILALLTGVDVKSPIDSGRKTLLHLAAAYGNVFMTNYLIKHGCIIDAEDEDEITPLLLAVYFRHIDVIRILINAGADPCNVNSKDRSPILYIKLWDNGEAIKIVRLGIEEKKVCKEKAMKLFLDANYNNLLYSCYCNSLPYLPYYNSSDRSDELLLIKGIFSRDFHQIQMLLKYGMSAYVQHKDRYTALHAAATIHPQFFPEVLSTMQMLYDRGADVNAKDHKGKTPLHVAVKHVNNQAITWLLKRGADVNARDNNGRIPLHAARNIFWFTGNKSNVNQTLELLLRNGADINAIWTEDRTLLELAKEINEVSTSKLILRELALLEVRGMTLNNRDLGVLEQDADMKLYYDKCKVELQFAKVCKIFEDTTLFDLLTKNMQALNIHAKNKDFRKTFTNLKLSDNFPIISRSLNKFIQHVDLINMTTHAAEVLSEVLSFLDDLVIQKILKYLSTEDLRVLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6S6</accession>
    <name>A0A232F6S6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000776">
        <property type="protein sequence ID" value="OXU26566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6S6"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF55">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="145"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="534"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="927" mass="107640" checksum="51BA6CC78C47724A" modified="2017-10-25" version="1">MPGGSAKIYQIELRDLEPLLRKKLGDDLELVDYAAESLLPSGENYGSTMLKVHAVIKRSRTADKEDLELVAKMLPPTDFQRAMFDSSYTFRKEAFLYEEMISSYQRLEREFGLRDEEVFDIVPEFYGARYSLTEDEGSFDDDAVLLMRNLKVLGYYTGDRREGLDLEHAKIATVALARFHALGMAMKQHKPEYFDCLKARSKALKFPDDNGFEECVNMFIRVMKQDPEIAVHSDFIEHIMPKASDPSHWFTVPPEPWSTIVHSDFWVNNIMFHKNPISNEVDDVKFVDFQNYLLMSPLRELTFFLLASMNADVMENGFDQLLNLYYEKFIDVLKRMRVDTEPFARDKFDARLKIDAYEELPHCSFMLKIMTSEVKEDEKFDNPDKFMQEDSIKMPEKIELHNVELRELESLLRKKLGDELKVINHSVEPLLPPGENYGSSILKVHVVVKKTKDADEETLDLVAKMLPPTDLQRMIFESSTTFRKEAFLYEELMPSYQRLGQELGAVDAFDIVPEFYGARYSLKGEEDFDDDAVILMQNLKVLGYYTGSRREGTDFEHARAAVKVLARFHALGFAMKLHKPEYFEILKERCKGLTPPPEQFYKEPIEALIQATSNDPEMSIHSDFVKAALSQDSSKNWGTKSIESWSTIIHSDFWVNNIMFHKDPKSNRVDDVKFVDFQNYQYMSPLRELIFFFVTSLKDDVMEHKFDELLDLYYGNFIEVLSRLKCDTNQFTREKFEERLKIDAFVQFPQSVVMLNILTADVHKDDVTSQNIFQEVLNETMLGKLRREGVRKGRSALDCKDATTHEFSAHVGLLIYFEAFMYNVLRLLGQQNSESRMMRFLMWHRKSMGLDYDRTKIAVQALARFHALGITMKHHKPDYFELIKSKSKPPELPAFASIFVRIVCGDPEIGIHSDFIKEAMAQKLKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7A0</accession>
    <name>A0A232F7A0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_009235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000792">
        <property type="protein sequence ID" value="OXU26472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7A0"/>
    <dbReference type="STRING" id="543379.A0A232F7A0"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="42"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU26472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="373" mass="40722" checksum="D067A120512523B6" modified="2017-10-25" version="1">MALLVRNVCKVLGQAPLKGSARTIHIGSVRFLESIEPGHKTKCTLIPGDGVGPELVVSVQHIFKAADVPVEFEPYFLSEVNPTLSAPLEQVSGSIARNGVCLKGILATPDHSHTGELQTLNMKLRKELDLYSNVVHVKSLPGIKSRHKNVDCVIIREQTEGEYSALEHESVPGVVECLKIVTATKSQRIAKFAFDYAVKNNRKKVTCVHKANIMKLGDGLFLKSCQEIAKLYPRIQFETMIVDNCTMQMVSNPHQFDVMVTPNLYGNIVDNLASGLVGGAGVVAGASYSAECVVFEPGARHTYSEAVGKNVANPTAMILCSVKLLNHLNLRKYSEQIRDALNRVLNDGKYLTKDLGGQSSTTEFTHAVINSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F898</accession>
    <name>A0A232F898_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000785">
        <property type="protein sequence ID" value="OXU26527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F898"/>
    <dbReference type="STRING" id="543379.A0A232F898"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="27281" checksum="20BC6DEA170C40D4" modified="2017-10-25" version="1">MVKYFENSTVFQFSWDQVAQGFWRRYPNPNSTHVISEDTISREIKDGKLYTKRLLTKTNRVPKWGERFISKNNVKIVEESIVDPKKKILTTYTRNLGYTKVMSVVEKVVYKVSDENPQWTVAKRSAWIESSVFGFSRAIQAFGLDRFKKNCTKMSNGFNYVLAHMFPSTARFMNPNLVQMGFSERVDEPSMIRLTHAAEDFQHSLHDKAEKMKDAAKKATDLAKQKAGPIYVTNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8D4</accession>
    <name>A0A232F8D4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GatA</name>
        <name evidence="7" type="ORF">TSAR_005572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01000698">
        <property type="protein sequence ID" value="OXU26925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8D4"/>
    <dbReference type="STRING" id="543379.A0A232F8D4"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="178"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="523" mass="57097" checksum="85D2DF73A1BB9ECB" modified="2017-10-25" version="1">MNNVLTSPIRTVSQKIAAGEIRPSELAKAALKATSVVKPLNAFITVTSELAKQQAQESDERQKKNALLGELDGVPIAVKDNFCTKDQPTTCASRMLADFVPGYDATVYKKLKEAGAVLIGKTNLDQFAMGAGTVDSYYGPSKNLWGSEIMKNYFFDDYFHDQEMQYDNDALSKTENWHIAGGSSGGSAIAVSTGTCFAALGSDSGGSTRNPASYCGIVGLKPTYGLVSRHGLIPLVNSMDVPGILTRTVDDAITVLNAIAGPDESDSTTIKDPYIPFALPSPVDVSGLRIGLPKEYRCPALSEEVDSNWSEVSQLLQEAGARVFPVSMPHTEYSIVCYSVLNQCEVASNMARYDGLEYGYRADENASTEELYAKSRSKGFNDVVRSRILAGNYFLLTENYEDYFVRAMKVRSLIAEDFEKVWHDGIDVILTPTTLSDAPRYHDFISADNQTQCSVQDFCTQPANMAGVPAVSIPIKLSKKGMPLSLQLMAPKLCEERLLGVAKWIEDVVKFPRLVIKPDSLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F975</accession>
    <name>A0A232F975_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000678">
        <property type="protein sequence ID" value="OXU27030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F975"/>
    <dbReference type="OrthoDB" id="7616892at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="138" mass="15626" checksum="6EA01B5829B28180" modified="2017-10-25" version="1">MTNWRVIRSDPIRDDAGNYSYEEIEIRQSLSTREYGEDGVISKLVSNAVIHALEALLTALLSPITVWQWLSKHDHFMMILRVVFEVALELIMLIVFAGVSILTAATLIFQDAYNDQTAHSTKAMIAELRDENDQGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F990</accession>
    <name>A0A232F990_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Histone deacetylase complex subunit SAP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the tethering of the SIN3 complex to core histone proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000604">
        <property type="protein sequence ID" value="OXU27424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F990"/>
    <dbReference type="SMR" id="A0A232F990"/>
    <dbReference type="STRING" id="543379.A0A232F990"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.550:FF:000001">
        <property type="entry name" value="Histone deacetylase complex subunit SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017250">
        <property type="entry name" value="Hist_deAcase_cplx_SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037637">
        <property type="entry name" value="HDAC_SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="155" mass="17540" checksum="75DB87E4DC7EB31D" modified="2017-10-25" version="1">MALAAESMALDDNKQIPDKPVDREKTCPLLLRVFCNTGRHHNIGEYTRGNVPSNELQIYTWMDATLREITALVKEVNPDARSKGTYFEFSLVTPEVRTSGYRMREIGVTCSGQKGADDNKTLAQARFTIGDYLDISITPPNRVQPVVRRGNFRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F995</accession>
    <name>A0A232F995_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000651">
        <property type="protein sequence ID" value="OXU27172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F995"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167141" evidence="1">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="8532" checksum="F42D33731D1F7A10" modified="2017-10-25" version="1">MKVYALAALLVCCIAQKDAKGNTAAAQQYYENARQELSTACVRQGNTADTANVCSQKVVSWVFNVSLDVSSTARACLANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA34</accession>
    <name>A0A232FA34_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_004454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000633">
        <property type="protein sequence ID" value="OXU27293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA34"/>
    <dbReference type="STRING" id="543379.A0A232FA34"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000187">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="18"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="538" mass="60502" checksum="00D5F6242F26CC64" modified="2017-10-25" version="1">MASPAPKSPEQSEKSRKYDRQLRLWNDHGQSFLESAHVCLINANALGTEILKSLVLPGIGAFTIIDGNKVTDEDIGSNFFLDADSTGKSRAQIATQLLLELNSDVRGDYIDEGPEQILNNSPDFFNNFTIVIACAMPEKSLIILSKKLWELDIPLIVCRSIGFIGCARVQIKEHTVVEMHPDNEIPDLRLDKPFEGLKDHFDSIDLEAMDLKDHSHTPYVTVLYKYLQKWLETHQDLPKTRVEKEEFKEMIRDGIRKDENGVPVGEENFEEAIRAVNTCIRPTTVSGTVSEVLNDNSCINLNSKSSSFWIIAKAIRDFMEHEGGGLLPLTGALPDMVADTEKFISLQQVYHKQAVADVEAVWRRTLMLLRQLGKPSDSIPEKDVKLFCRHASELCVQRGTCIADEYDPKLINTNKIAQELENPESLMVYYVVLRGVEKFQAEYNAYPGEFDDHVEPDIVKLKACISKLLGEWGCGPLVKDDYVHEVCRFGGAELHSISATLGGLVAQETVKFITHQYKPISNTFIYDATILEGATFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBM1</accession>
    <name>A0A232FBM1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000523">
        <property type="protein sequence ID" value="OXU27870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBM1"/>
    <dbReference type="OrthoDB" id="10663546at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012940766" evidence="1">
        <location>
            <begin position="24"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="422" mass="48068" checksum="79EDBD2EB30E3C33" modified="2017-10-25" version="1" fragment="single">VMPTLRKIACIAILCLIFGASNAEIKTVWEKRLMFPDTQLYFPLENLLKDNSEHFDSFTYALCETNEDKSEKICKVVLETKDHTERFCDVTLKVSKGKDYKIFEEMKMTQYGPENIMLLWEEHDEGNGNIKANVVDMSNCQTEEVMVYASAKKYHIRRINMIAYNDTTIDLVMQCGEYAQLCKTNINAQGKIVTFTKPWTTDIISEAYVNSAIHHSKSKGYLMYSKGAYKYHKLYSVKDNGKWKLLKQSQDRLGPSLLSTGHGMISSVATYTDFRILGNNKVFIWRFDVEGNLKLDKTVKFSNFILYSDIQNLADGGFLLLTVECQGTVSSDCKLINDMTYRVKKFGADGNQTGTLEFPETRKLFSNNYTTPSFGLVRVFEKEAKEYCLSFVTGCVACTRGLRGPSHLEIVVECFSDSDFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC17</accession>
    <name>A0A232FC17_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription termination factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RNA polymerase II termination factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Transcription release factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_001501</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000467">
        <property type="protein sequence ID" value="OXU28172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC17"/>
    <dbReference type="STRING" id="543379.A0A232FC17"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000043">
        <property type="entry name" value="Transcription termination factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF50">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="605"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1020"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU28172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1186" mass="134875" checksum="72A88C465ED9E67D" modified="2017-10-25" version="1">MSWRITEKETKHQDKMNYRNSKREQCSSSMDDSLIFESSGDESDSPYSKGNSTAARTGVINESDSSSEDSERHDPGSDQSIDSEEEDIQFMNMSHRVSIVESSSESDSDNDDLYKQANKQSKNLKRRSIYDNPISVDTPNSISTPIHSRQLRKKARRVMYSDSESDKENFSGNQEKSKNAIMDEGSEDDIEEINSESENPRKQKNVLNESSINISNQSSNYQDSSKGSNNVNKKSSEHLDLISDDSYNELGNLKPASSNDKNTSEVETENVAVDRNSISERKSTSKNESSYELESDDAEQSFENVTNKSEGKFIPPRNRPFFTEKKSASNVIDLTMNESMHEHSMNDKVKVSKKEQKIEEDGVIICSSTSTSENEMDNEVITLAKKEIGVGNIDPIEAQKKELILLNIEHSQKQLDKLRKFATSVDINRLPDKGAKVHKSMEELETKIASFKEKLAKYSRKTNTPARLSSLKVKEESKSKVKPLMEKNLISPLSEDKMDVKKKIENSHVKRELYTNNDPAFSEQFDNFDVHEIPKVPQTSFKTDDLGKKALETLNKQQSLTTKRLEQLHGSLTSRPAEDQREKDPAGLKVPLMDHQQHALAWMKWREKQKPKGGILADDMGLGKTLTMISLVLATVNDEKQNDSDDSSSSSSDDGWMSKNKHKRYYGGTLVVCPASLIKQWEAEVKNRCKRGLLSVLVFHGNNRAMDDRKLSKYNIVVTTYQIIVREAGAESGMYRMEWNRIILDEAHYIRNHKSKACIAVCGLTAKHRWALTGTPIQNKEMDLYAILKFLKCSPFDDLQVWKRWVDNKNDAGKQRLITIMKGLMLRRTKQELQAKGSLDSLPDKSIELIEIEMDRDETLAYQKILLFSQNLFAQFLAQRAEKQHVRELYGGKFDKPSYSSYGSKTQFTKAQKVLLEHHSSIEAHEILVLLLRLRQMCCHPALIHAMLDQQDAEVNGLDEDIDPNTELLNKLQNMSINHEDEEVEDYVADYKIDNRVAANLLTKKNPVFDDERRSSKVRAIVKTIEEILEKGDKIIVVSQWTSFLGIVAKNLDDIEDAKYAMFTGNVAVKNRQAIVDKFNDPNEDTNILLLSLTAGGVGLNLVGANHLLLIDIHWNPQLESQAQDRIYRFGQKKNVYVYKFICKDTIEERVKNLQDKKLEIANHVLTGSRAVSSKLTIDDLKLLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC62</accession>
    <name>A0A232FC62_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_010956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000456">
        <property type="protein sequence ID" value="OXU28265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC62"/>
    <dbReference type="STRING" id="543379.A0A232FC62"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000010">
        <property type="entry name" value="AMSH-like protease isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="243"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="429" mass="49630" checksum="CC85189194B1F453" modified="2017-10-25" version="1">MEREKDKSDVKSHKQSLRNDMPKLISPETRLQHCFDTGKKFSFEVNNSIMRYYRSGKELIRQADVYTKEGDLEKGYILYIRCLTIFLEKLETHPEYHTIPANDKDHIKNTLKEIFPKTEALKKKLLEQYKHEYAKQKQEYEEQERIELERLRQEQQRLKEEEEERALQLNSSAHPGALKLGVAAGALTSADEFRLKRHVIPPKTYVPSQYDEQAQSSKDRKVPSVDRSTKPTSLTSGDRLRDIVVPSKLMQNFLKLAFSNTSNNIETCGILAGRLERNRLLVTHFLIPKQTGSPDSCVTHNEEDIFDFQDQHNLITLGWIHTHPTQTAFLSSVDLHTHCAYQLMMSEAIAIVCAPKYDETGFFHLTPDYGLNYIANCRETGFHPHPSEPPLFTVRHKCNHISELTYSLTAKHFILDPLAPIEAVDLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCF9</accession>
    <name>A0A232FCF9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000474">
        <property type="protein sequence ID" value="OXU28129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCF9"/>
    <dbReference type="STRING" id="543379.A0A232FCF9"/>
    <dbReference type="OrthoDB" id="7398970at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032150">
        <property type="entry name" value="DUF4820"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16091">
        <property type="entry name" value="DUF4820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="490" mass="54017" checksum="F6B6EB35ECBE2BA6" modified="2017-10-25" version="1">MCMCSVDIIDKTENIGYTYGQLYVFEALSCRGRNIMDKVNGLMMSGVESAAQMFIGQAFLRLIDRILWIVEKSVQWSLPSQEVSAKENGKTFGEVELVRPLPWIIFLPALLFLRIIRIGLDALGAILGYPQVEPSDMVRVIQRGRRRIRAIKSSGLKSMRLRSTPAIKDRATTMREASRNLAKSIRLTLSTLSCLDSASKTSPSPPPTKIRVSNVLAAVPPMSEETSGIDSAVGSPNQDYSKRKYSEIGTDESSLDESDEETLISKINRLADASDSDKDFSISDCPSVGRSETSASESEADVSIPLSEVEDLKAEKEEMEKQWCDNPQCTKTTGDNELHKLTECLVKLEKLNAQPSINGSKDQEEPEKDMRETLATNGVGNDRDTAYYSPISWKSVSPEVSIPSDKQDNHIDVGEKPMNELNNGQLYGGEEINEDCDIGSKNSCASGFSGQQTGESIKEKQRSSSQSSGGGAIKHHQKHKRGNYGNRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCJ0</accession>
    <name>A0A232FCJ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000419">
        <property type="protein sequence ID" value="OXU28534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCJ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="95" mass="11024" checksum="6C0266BEC247EC94" modified="2017-10-25" version="1">MEPRCLQVLRRRHGILSIFSPANAHYNKSANSSLQEKTHYKFWEKPLRSLGFSEGACEWATSYLTDIGLGWLLFLERSVIYGVLLNTRSTIYTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD06</accession>
    <name>A0A232FD06_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000397">
        <property type="protein sequence ID" value="OXU28671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD06"/>
    <dbReference type="STRING" id="543379.A0A232FD06"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="84" mass="9476" checksum="B27AF375B7B46AA9" modified="2017-10-25" version="1">MYPKLIKPNTLVIQEGDIGSHLYVSAEGEFDIYRGTNFQHSFGPGVAFGELALLYNTKRLRSISGTLYMIQQQKCTSTISRFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDP0</accession>
    <name>A0A232FDP0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_003281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tropomyosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000384">
        <property type="protein sequence ID" value="OXU28762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDP0"/>
    <dbReference type="STRING" id="543379.A0A232FDP0"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000005">
        <property type="entry name" value="Tropomyosin alpha-1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32970" checksum="BFBEDE7C55F67BC9" modified="2017-10-25" version="1">MDAIKKKMQAMKLEKDNAQDKADVCEGQAKEANMRADKVNEEVQDLTKKLSQVENDLITNKANLEQANKDLEEREKLIGNYHRAQAESEVAALNRKVQIIEEDLERSEERLNTATAKLAEASQAADESFRMCKVLENRAQQDEERMDQLTNQLKEARLLAEDADGKSDEVSRKLAFVEDELEVAEDRVKSGEAKIMELEEELKVVGNSLKSLEVSEEKANQRVEEFKRQLKTLTVKLKEAEARAEFAEKTVKKLQKEVDRLEDELGINKDRYKSLADEMDSTFAELAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FED0</accession>
    <name>A0A232FED0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000344">
        <property type="protein sequence ID" value="OXU29045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FED0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="99" mass="11492" checksum="FEFFFFE0FC2B9135" modified="2017-10-25" version="1">MADKVVENKYTINVMLLPRTLCSLCELSFKRARWNWSSRKDQSYEHSVKYYEYYHEVQKKASRRAQGQVIRDAVLSSAGAKRSKSSLTSSPDEKIERAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FEI1</accession>
    <name>A0A232FEI1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000362">
        <property type="protein sequence ID" value="OXU28878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FEI1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012918029" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11072" checksum="CD00D182000CFB0B" modified="2017-10-25" version="1">MTKIALCILLAIIGVAMGYPSGFAPGYYPTYNTGLNNLYNQYPNQYNNPHYNNYPYAQQYPGYRQPTFNKASANAQASSNTGLFGGQSSAQASAQAGCVHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF56</accession>
    <name>A0A232FF56_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Solute carrier family 25 member 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_009805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000356">
        <property type="protein sequence ID" value="OXU28947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF56"/>
    <dbReference type="STRING" id="543379.A0A232FF56"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="159"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU28947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41633" checksum="ED227A5C5776D30A" modified="2017-10-25" version="1">MKMTSIKTSDIDLDDPRFRIKPYQQMIASCTGALVTSFIVTPLDVVKIRLQAQQKAMLSNKCFLYCNGLMDHICSCGNGQGGMSQAAWLKANGKFTGTLDALVKISQKEGIRSLWSGLSPTLVLAVPATIVYFVSYEQLRLYIKDSYNTYARNIRHVEQPFWIPMIAGGTARIWAATLVSPLELIRTKMQSQRLSYAEMQQALKTVVQQNGVRGLWMGLSATLLRDVPFSAIYWFNYEGIKKKFPSSQQTFAFSFVAGALAGSIAAFVTIPFDVVKTHRQIEMGEKQIYSDHPRQSGSTWHTIKKIYSTSGIKGLFTGLTPRLVKVAPACALMISTFEYGKRFFQNYNANRALLEMNDDIHWLDQKQNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF72</accession>
    <name>A0A232FF72_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000304">
        <property type="protein sequence ID" value="OXU29345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FF72"/>
    <dbReference type="OrthoDB" id="2386367at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1801"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1846"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1869"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1891"/>
            <end position="1907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1986" mass="223939" checksum="0C9193040C0C61FA" modified="2017-10-25" version="1">MAHLQQSSSGTNETTVQDILNLLDEGETKIKMSASKDVILFLGITGTGKTTASLFIAGYDDYIIAEKNPNGKGYTVTDTLDSNIDGAIYDCPGYTDSRGPLYDISASYFTKKIIDHAERVKLVFTISYAAVDSDNKDKKSFPELLNYGVAMMTNIAKFNQSIGLIVTKVKNEYDLQEVNGTLIPTLVPNEIVIKDIDVKNDLNTSTTSNKAEKIQFINALLTKANGNYTNIGILRQPNQPGKYRNITILQDLKPSLLKVVNNNIVFKTHKKSDFRHTISDNSKIYLRDLIEKINEDIVSNIAKICKEIEKYCSNRIEPFNDFQDLHNKFRMGYNLFSSTKTAAISFEEPRQMVEQITKNIISLNITVSNENFQNIINLSEYLQFIKTINNELTVVKPVEWAEGLTNLVTYLDDSQRWYNFLINFYDILSKYHVQQHYQQHFDTVEKLENQIKLNEKNPSVISKELKLFLDKVSKADSEKEYDNIKNIRQLSAVKLKFLNNLLNLTLKYNVDSSCDSDNNLIIKGQYVRLNEANSASCKKPKSIRIFALDKVFIDTDLNKTGDRVQLSIIAPKLEIIGSPSIILNGSPGASFIDEQAKNASKPGAKGENGNPGNPGGPTGHFISISQNVANSEHLKLSIVGGKGGTGQKGGNGKEGQNGTIPPVPKDDDDPWWDEREFEVKDDIKMNMINSGDFPRSNFVEWKARWWVRGKDCTDGGNGGDGGIGGKGGNSLDPIVVNLMESPKFEITIDKGAIGIGGPGGKGAAGGKQRGQLLTLDGYSLKAVSSWQSPTPSYKYTVVSREDLKKCSAGHEGLTGKNDANIKESEEVSFISLPSAVINDYKNYVRDNMSNNMMESFLRKFLDGLEHHESLKKLYDIHGIDQYADELHAEKRLTDDNKKVLGFLHTSVLSRIYSINNSAGNKLVLDLDAFLKERIREIKKLKELESVVSVNDERKRYQNSLLEKINEAQNFVEEHITSELNNVLHGVDHQIELLVEETIALQNETEAAKDKIEKTREQLKNAGGLKVLVAVLKTASQFLSFLGPVAGAAGAVIGGGIMVSEALYFKDSDGGSANPVDLPNAVKNSVAKITEQLKDEQSLFKAQLDDTQHKLKDFSEEKPSTDMSDIQKKISEVKQQLEKEMNVQNSIDVEAVDKLYKMRKDVQDFLQKKREMLENKKTRGNNKNNVEDEGNGEGEKEKKEDEINLVKVIENTFGIIKIPLDYYNRIKNDEAKIDELGRAMRKLDENLYQLRVYEQLIYQIIAPTCRNLEDKINKMGSNLQGQSHAALDISKWRIQDSLRDMKLQMKQMTQGFRVQETLVRSIEKLEEGMTIMIKMYDRIEDYHDKAELSDYIANIYSNRAGQIKIENDELRREVDSLKWIIQSNLVLEKYEVSMNSFKQRIFPFGDYFFAEFELPSNLVSNDTNSLVVASDEKISLLRSKLEESKITMTEYDQYIHSRVPFNSNLAISKPFFVWSHDEYKNAIKQLLLGEKIILKSDIMRGSKQNAIKFNVVGINFKLENETMQSELNEQLKYLKVEMMHMGTSYYRCHNKFYTIVSDNQTLMYTFMKNENGVPQDSSDSYKKLEKYEPFLSPYTLWSIQLRKYDLSKDNIFASLANYTNEKIDLELEGVGQYVDKDFTTLCNDNLNKYYAVDDTISLIDNINSQNKHPLQEIPRDSLFSTRRTGLMTYGYFNPINKISHWFTKEDKIIEEEDFMTLDDSASVATKWTNIPSTGSELPTFTNTFINDDTSAVDSLPNYFSICNNENLLLLDLIIPWTDSSSHCLCVAGEVYCWWQKYVASKSRSSDNPISPEEEEHEEDEGEEDVAEDEEDEDDPSSWTTEEESDYAEGPSESPEASGESALLEASGEQQDDHSIAVSKEEASAPETLANLTMSSSSSTTTTATTTTTVRPTRAPATCLVMGRKYQEGEVLPHSTGNCVECSCGSEGRIECSPRDCVGLRPQSVEAAGAGDFELFDFEHERGIEESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFI6</accession>
    <name>A0A232FFI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_006525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000306">
        <property type="protein sequence ID" value="OXU29323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFI6"/>
    <dbReference type="STRING" id="543379.A0A232FFI6"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="812"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="864" mass="96192" checksum="A412E4507C8D5DE6" modified="2017-10-25" version="1">MSMTMSTEEKIRHYQRSIDRSVEDKARLLHCIQVLSKLPVTVQHLQNTGIGRTVNALRKIDEGVGDAAKTLVSKWKYMVANTDTSEDEDEACVPDVPESYDSPECDCEPEKSSNDVQTNGPAALRVAPPVASSIVFDEDSPPNSHRHSANNSRKVDSDDQNEELEKTRGNHSDDTHEEEKTTSHKSSSSKDKHASKSSKHSAQSSSKDRSSNKESDKSKSTHKHTSKHDHKHKYKSSRSDKDSENSDHKSKDRSKSKSESSQSSSPSTSKEKKHGDENEKKRKHVASSSDEESYKKKKMKVSSDEEDMDTDKFVIGADRSSDDGKQEDMEVVEDHKEKKRSSSSHSKTKDSSLKGESQSDKSKSKDEHRSSNSNSSKAKSSSDTVKKDERHSTSKSDERGKESKSKSDEHRSKELSKSKTSHSSSSSNSKDKENDRDKDKHSKDKAKESSSKSQKDDKEKSKIKDKEHKSKSKDEQKEQKKHKESNDSKEHKEKNKLKNTASGDGEIDCNSGTSFADALGMCTMLPPSSKKKKENTSSSIPKTVSSKTEKHNSSGSSTPTNNRASTSKINSEPPNSSDALPLLSPNIKLGPLPIQKGVDISSTLAEPSVRYEPLPPTPKICPSKRKETEAHLLSLAIYAKSARTKVYSGNKTGYTNVPTLYDMCIRVLIENIDALEYTGGVPYYIIKPVLERATPDQLFMLEHHNPYLIEDSGPLWQYHCNKDFRNKQREEMESWREMYMRCLDEREAKLKALTANIKQSIDKSAPVRSTKLAYVDNVVKPPRSVLRKQAKYGTANISSKSSEIKKKIIAAAAGPSSGASSNERISVPPPPSSRARMTSSSTIKKQKAPLMAKALQAIRGRYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFK1</accession>
    <name>A0A232FFK1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000312">
        <property type="protein sequence ID" value="OXU29300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFK1"/>
    <dbReference type="STRING" id="543379.A0A232FFK1"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU29300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="173" mass="19698" checksum="7032CACC056F06FD" modified="2017-10-25" version="1">MYSKTLSKKATSALLSRKKPFAKFELTEEQKVDIKEAFDLFDPDGTGKIATRELKVAIRALGFEPTREEIRKLVANVDPDGLGKVSFEEFLDIMSSKMAEKDSKEEVLKAFRLFDDDGTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEISQEEFLRIMKKTCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH39</accession>
    <name>A0A232FH39_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000244">
        <property type="protein sequence ID" value="OXU29759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH39"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="10287" checksum="CF9EC927DB005A98" modified="2017-10-25" version="1">MLKKARESRLPPRVTRRVDHGNDDSNVARARIISNHRLLILPLRLTGFTRWRRDVAPCAREIQSWRMFCCERKNVCERERELAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHC4</accession>
    <name>A0A232FHC4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_003028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000229">
        <property type="protein sequence ID" value="OXU29858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FHC4"/>
    <dbReference type="OrthoDB" id="10051111at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21990">
        <property type="entry name" value="HMG-box_CIC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000010">
        <property type="entry name" value="Capicua transcriptional repressor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032147">
        <property type="entry name" value="Cic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058607">
        <property type="entry name" value="HMG-box_Cic-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058606">
        <property type="entry name" value="HTH_Cic_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF13">
        <property type="entry name" value="PROTEIN CAPICUA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16090">
        <property type="entry name" value="DUF4819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25981">
        <property type="entry name" value="HTH_Cic_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1180"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1542"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1848"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="967"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1180"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1195"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1551"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1585"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1598"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1624"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1870"/>
            <end position="1879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU29858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1879" mass="208934" checksum="01F88682D8F41093" modified="2017-10-25" version="1">MLGSCIYEHNLALGEGSTKVTTQNLSLIHKTFDVTQPVVEAQKISRNIMLNADPEKYGSKYQECSYPDTLAHNPSSREMEDSVLRPPVAKKTISDPAVSAKKLPKKRKFIPSELDELENINNSYGSSIITNPNPEPTVMVPSIPMPEPIQKPPAKTNEVYQLLTNPVVTPPQKTAVDYSLREEDIHQKTYNHQPATSIIPTITVNIDLNEWKGHRILASRNNQYYPGVIKNAVDEDLFIMLDSEPEIYKFSNILSSRKFDVISDASPSSTQITVDTKVCFRRPNAMNLSQSETASNVFYVGTISRILLKPTRFVVEMLTKNENYIVKRADLRLIRPPWWDEIEETFEDQKSLSFESNENTSMCNNLESSNPLIQSNKSSQISHVSGDKVKCYYRTTGTSPFMPLMSGIQSTSNLVSNSADPSYDDFESEDDLDKEDIAFTLDGDVKLSGSSKRSSMQSRGSTSSLIEQRSITPRSQAATPRSQAATPHKYKKGDVVVTPSGIRKKFNGKQWRRLCSKDPCTKESQRRGFCSRHLSLKGSGLRGPSGNFSGKIDCEDTSRDSDTSPNYAERRVAGRFDQDETEAANMLVSLGSSRSATPAFSSPTGQASISPCVNNSPVQALGLNQNNVFMPISNPEKNMTSLVSPNISKWKQSPTQTNYLVQYNDQPVIKPEPNRMIFPSKPSPPIMNSVTTSIGTSVIRISPVGGRTTNNHQNISLWPERNNAIFKHTIACSSAQENVMILQDVLTSTPNRSINSDLNDSHTLNRSQSPIISTFQDHRMNHEDVIVDSSDNIHPYTGHVNKSSMNVVNQRLQANFLVIKNGSDISAQNTVIQEDVIPPQTTDNIKSFQPRIYHVDNQHEQPCSPNPVQIKSINICDQLPQHETNPQQESKHGVSEESHRIPSPLSVVVSAISSNKISTSNSIFQQVIVQPAGVPSFNSKGLIITDENKERDNMQSYTWSRSTPEKTISLPPSTLSPPLSAPPVSIALNKKIKENHVPEPLIQQEEEEDDDVFEAEGSLATTNEANATKRRCHSLSALQSKDLQSPTKIKDRIRRPMNAFMIFSKRHRGVVHQRHPNQDNRTVSKILGEWWYALGPEEKQKYHDLASEVKEAHFKAHPDWKWCSKDRRKSSTSLKMNEMRGKLNSTGEELEMGAPDDVPLTSKVLDECISTKSIVADDNQSMEVTKSHSQSLQELSKDVDQTEPSLSRDEEKGHLDNSQIVICEDNSCKESLKCKHNLQIDVDNESHEDCRKCFTSSNSRTSMKKEEVTCRPKPIKARLATEDEEALKYSQSTSLKCGNITVLSASYPYSSPVNPTGVSGFQPTGGAFITMPISPKIVQQEPVSNCEKQSTCQHTINNCNCRVGDKKILPSTFTTDSLAKSNISTQATHYLREENTAMCIKQKPKFMLTVLEDPASTVSNIHQSQSYQTVNSNIHCVGQISDGTKKKVDFLQVPSKNNVKPNTVIVNQSLHVLENNHNFSNYRTICHTSPPEDTNNTFNPSPNVTSLYGTVSFNEQNKTSEDKNVLPELSYSNATYNQNFEKAKTKKDSALGTQNDSLDSANENNKGVFTLAPTPAQLGKAPLQKRQSSVPSSTVSRDTNSANSSQNSDSDMSSRITHSDLQEKQTSIGDALVSPTNSGKKMSFFKKTVEDGMDKVLEQVNFRQKFSSLPEFKPEGINSPSAISLNITTSTSNSTNQQNYRRNPLLTPIRFSVHNKEESDSSVSITPNTTSSIKLTGNTFFGPDFNIEEYQAHPDLVTNDSENSPHTPKTPSSAVINVGKETERGHRKVLEQRRQLVMQLFQEHGYFPSTQATSAFQAKHTDVFPTKTTLQLKIREVRQKLKANSTPISANNLISPQPVCEGTSNNNNRTGGGLQKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHI6</accession>
    <name>A0A232FHI6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) kinase</fullName>
            <ecNumber evidence="2">2.7.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_013143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000182">
        <property type="protein sequence ID" value="OXU30226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHI6"/>
    <dbReference type="STRING" id="543379.A0A232FHI6"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13158:SF5">
        <property type="entry name" value="NAD KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="411" mass="46634" checksum="4DAD5CB8912A435B" modified="2017-10-25" version="1">MTALAHLRRGAYRARQIFKTTQNTNKILHLSTRLESSFVPKRVLVLTKVSRYQIEKLQNPDLSENQLKDKLLSRGTNYDAILAGHNRNKATESRTVEALKNLNITYRVKDRHSIDVDSIAWADLIVPVGGDGTFLLASNLINDNTKPIVGINSDPEFSEGFLMLSPKYTNNIPEIFERLRAGKFEYFMRTRIRTTLHGENIWQMPFHMHDNSSCCADDKFYVIHHLSTIPKGELPKERRLPWLALNEVFIGESLSARISILHINLGKETFKKVKSSGLCVTTGTGSSSWYRAISALNPQMVEDVLTMAGCKKIPKCEEMKKICYDFNSGLQYPADELKLSYVIRDMIFKHIWPMPKSIHPRGFCDKLTVRSQCYDGGLVIDGGIAVRFNVGTTAVLEAREEDTLRNIVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHM2</accession>
    <name>A0A232FHM2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_000430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000231">
        <property type="protein sequence ID" value="OXU29837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHM2"/>
    <dbReference type="STRING" id="543379.A0A232FHM2"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU29837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="142" mass="16049" checksum="CA5C58ED11DBE626" modified="2017-10-25" version="1">MKIHVKVLLGEEHVFDVLPTDTVLQVKQKIEERLGIDVSHQRLLLLGKALSDDKELSFYPGIKDGSKINLVKKAPQATESKNGVFIFKEEILKVLRNYYSEADALTIVNETIKDLQNKVNLLSFDDLERLATALVQDQESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI14</accession>
    <name>A0A232FI14_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000164">
        <property type="protein sequence ID" value="OXU30394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI14"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="59" mass="6842" checksum="10A8E5DD66B6A98E" modified="2017-10-25" version="1">MRLIFCHDRCSTSICLSATAMLEPEWQYDTATYDSPAIYNMFHGVMLANRVRSKVAFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIK6</accession>
    <name>A0A232FIK6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAM69 protein-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_016716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000176">
        <property type="protein sequence ID" value="OXU30299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIK6"/>
    <dbReference type="STRING" id="543379.A0A232FIK6"/>
    <dbReference type="OrthoDB" id="10035316at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020519">
        <property type="entry name" value="DIPK2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32073:SF7">
        <property type="entry name" value="GH11358P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 protein-kinase" evidence="6">
        <location>
            <begin position="179"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU30299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="404" mass="46220" checksum="D3D2C4A8E9C5F543" modified="2017-10-25" version="1">MLVTKASVSSFLIALLILILGIYINRFNLKVAEITERYKCPACFGDSMCQVIDSNEISFEYTDFYSIFNNLFSVKNVYYGKYKDKKVIMKKLAQESELKTFDEMICSDDELHELCYQSESRKQDSKKNFYKLVESELANVGGDINNKMRLCPTTTKLEKLFVNVKFQSHAENKDYFKYLWSTIKINPEPLILQILPAKEGWPTPKYFGACGRLIVEEYIGLPLSSFIDEPWIRRAKIASSLLQAADTLMSKNSEFAFYLTDISMDNIAVNNEDKAIFVDLENIIIVEKNPPEKALVGIESWNETYTNAVDLDCQDCFVFSPNDICSHKVSDHNFYAICQHILTQALGTVFHNPGFLHDPPDYILQKHPTLIDLLEQCAKPDIGYSRIDIAHHLIVLLDSVIENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIZ9</accession>
    <name>A0A232FIZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_007299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000134">
        <property type="protein sequence ID" value="OXU30655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIZ9"/>
    <dbReference type="STRING" id="543379.A0A232FIZ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="44"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="169" mass="19902" checksum="F2E6A517F2885951" modified="2017-10-25" version="1">MICVKIPERPKFHLYLKILQNHPPSGYTCRRFLGAKITSWMARHDVKTHVTVIAKSVKHMNWHSFTFVYQTDEALSRIQETLKNQGRPNYPITIRELQPLYKINILASEKERDNIYESLVKEIKSSQQYSLLLDVENENLSQLLDVMNKMGLMSDYFMCLITDLLIFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJF7</accession>
    <name>A0A232FJF7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000110">
        <property type="protein sequence ID" value="OXU30874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJF7"/>
    <dbReference type="STRING" id="543379.A0A232FJF7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF61">
        <property type="entry name" value="ANKYRIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="496" mass="56378" checksum="5929CE263512CE09" modified="2017-10-25" version="1">MDNDTPLHSAIRNFKDDLDHIKILLEDDDSDINVGNSKGETALHLAGQNKRCSEELIKLLLAHGADVNATTSPDGNSVLHLFAGSCINLDTNEVATILLKHGSDANARNSKGEIPLHMAVKNEECSEIVIKQLLEYSSDVNASDLKGDTPFHLAMANYKCYDYVMIRLFLTYGADVSKRNGMDETPLQAYYNGKTEGSCPVDPRLQILLQTREEQLENSSELHIACLYGKPDQVQDMLLQLGADVNSLDKYGYSPLAYTFLRFHDDYDRWHIVQSLLHYGANICHQITLENDSKRSLIEVGMASYSYRNRDESEPQKMLFGIIDYIEHIAKLLKLYEEQAELGINSEALQNLQGILAKNRFYVILMTILNDSRLSKESLLSKCSKELEAMRETRLGESRQTFWDLMLAKTAESYVKNKKLVEAFYAKHDIFPMYKGILDAKIDKALERQRLIDNATTSFFNVLNFADPSDEFYERTLSYCSNKDLMNLIDGLKERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK83</accession>
    <name>A0A232FK83_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000081">
        <property type="protein sequence ID" value="OXU31156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK83"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="8031" checksum="0AFCBCFD68542F8A" modified="2017-10-25" version="1">MIGWVLEEHLYTITPTGRIKMSVENFLYICASHCQSGSGKFGGLENMKDRRDFLYEYTSPSTEMFEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKL9</accession>
    <name>A0A232FKL9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_014237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000090">
        <property type="protein sequence ID" value="OXU31080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKL9"/>
    <dbReference type="STRING" id="543379.A0A232FKL9"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="54"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU31080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="248" mass="28101" checksum="9C2A16D526FE8355" modified="2017-10-25" version="1">MFESSKQFLRSFHTFRALLKEKPTNLKGKKHSSQQWLSRQFKDPYVEKARQENYRCRSAFKLLEINRKHRILSPGLHVVDCGAAPGSWTQVATQLTNSHGKMLGEPVGKVIAIDKLPIHPIEGATVYGNLDFTTKEAQNILKTALGGKFVEVVMSDMAPNASGIKDLDHENIIKLAYMAFKFAIEVSCYEGTFIVKVWDGYKCTKLEEDLARFYRNVKIARPQATRDESSEKFIVARGFKGLRTNADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL58</accession>
    <name>A0A232FL58_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rac GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_005846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000061">
        <property type="protein sequence ID" value="OXU31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL58"/>
    <dbReference type="STRING" id="543379.A0A232FL58"/>
    <dbReference type="OrthoDB" id="2218807at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04382">
        <property type="entry name" value="RhoGAP_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000033">
        <property type="entry name" value="Rac GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="11">
        <location>
            <begin position="386"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72259" checksum="09F791FB82648AB0" modified="2017-10-25" version="1">MSSSLSVLASYDELVRCTNVLVNGSCEGEFLQFAINQEEMRQKWLASVQECQRLHAALEKAHDEAAKLEHKVSHARRLLDEERRRRRTAEEQRNASERQITLVRELLLNDGGRNLNDETREKLQFLNNTTLNGRHSNSQFKDHLHDKLNTITELDSTGSLLSDSCFSKSEDDLDTSVILQQNHKKREWKEHRPSGEYVINKRRRSTLQKAVDLNSSDRIVATTTLVMPKDGAITASSVIEAIPGDENKDPQQSTSSQQLNSSRKRRKSAERSSKSRGGQMDKDPIPSAPKAEIMTSNSDSENCFKPSPNIGGYTISTKASSRGHNFMEKNYVIKPEVCTPCGKRIRFGKAAIKCRDCRSVCHLECKDLVPLPCVPAGNTPLRGMTGTIADYTPRIPPMVPSLVVHCINEVELRGMNEQGLYRVNGGTSDVKNLKEKFLRGRGAPNLSEVDITTICSTLKDFLRSLKEPLITVALLDDFARAAAIRDKQDADAAIYQAISELPQPNRDTLAFLVLHLQRISSNPECKMPISNLAKVFGPTLVGYSCQHPSPSSMLSETKNQVAIVESLLNIPSDYWANFVNPEQLDDIGTPKTSRLDLRHTPSTESLPALKRTATTTKGFFQTPLSSSKSFMKKNKKYFATPPSKQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLZ7</accession>
    <name>A0A232FLZ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLZ7"/>
    <dbReference type="STRING" id="543379.A0A232FLZ7"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="4">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="120" mass="13446" checksum="CF529B6A4A887171" modified="2017-10-25" version="1">MLNSAYAERYMGSPNFTANYQGYVEADLSNKVEHLRNRMFYLIHGTADDNVQFQQSMVLVRSMAKKGILFRQQVYPDVSHSLAGVKEHLYLSMAQFLDDCFLKQVPVDSKAGLSSGGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM54</accession>
    <name>A0A232FM54_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000046">
        <property type="protein sequence ID" value="OXU31589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM54"/>
    <dbReference type="STRING" id="543379.A0A232FM54"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="124"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU31589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="400" mass="45081" checksum="5C8FA7924E67A0D0" modified="2017-10-25" version="1">MEGLKAMIPLNFFECALCIPQYCCGALFGIGFCAYYFFEVVKTPLLVCARGPFYDFLNENVPILKSKFWPTLWCFESRAQTIFASIVRARYLPRMKYRRELLTLSDGGIVALDWAEENTNPTSPIVIILPGLTGASQAEYIKCLVYAARNSGIKCVIFNYRGMGGVKIKTPKFYCASSCEDLAEVIDHVKKLHPHIPVGATGISMGGLLLGNYLAQNGSDAIGKLKAALIISVPMNIFEATKSIEKPYINLMLNKYLCDNLQRILRRHVHEEDDFPELNLQEVYKSKTVREFDESFTSRHFGFRDAEHYYSYATLHNKLHLVEVPLLCLSAADDPFQPLQAMPLQEVSKSKNVALVVTSRGGHIGFLEGFWPLKEEQYIGKIFSQYFTAVFSVGDDHPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN24</accession>
    <name>A0A232FN24_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alkaline ceramidase</fullName>
            <ecNumber evidence="9">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_002972</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01000006">
        <property type="protein sequence ID" value="OXU32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN24"/>
    <dbReference type="SMR" id="A0A232FN24"/>
    <dbReference type="STRING" id="543379.A0A232FN24"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139">
        <property type="entry name" value="ALKALINE CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46139:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="269" mass="30985" checksum="DA85E8AED2BCF98A" modified="2017-10-25" version="1">MWKPFEPGSSPIDWCEGNYNISPSIAEFMNTLSNIVFLLLPPVLMHLFRDYGRFVNPGIHVIWLLMMVVGASSAYFHATLSLVGQLLDELTILWVYMAGFCMFFPRRYFPTAAKNNRKRFSLFATLPTLVATVLATFHPAINAFALMTLGIPAFAFMILELKRTKSARVYRLGLRCGAAWLLAVTCWLNDRLFCDTWLNLNFPYLHALWHLFIFIASYTAAVLFAYFSVKEERPQQSPMLKYWPRDDFELGIPYVTIKSYIKVDTNTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNZ7</accession>
    <name>A0A232FNZ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000008">
        <property type="protein sequence ID" value="OXU32087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNZ7"/>
    <dbReference type="OrthoDB" id="7699561at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU32087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="406" mass="45051" checksum="4537B2B1887D6BA9" modified="2017-10-25" version="1">MSSLIVRHDSRMMMLEFAVEKLFVPSNSPFDAVIMSKYIVSFRFLDDEWIDVTPNRLDYKQYRGSQGTEQLFHGGKSLVISVPSSFLDCDSENLSMEIRARREISRYFETEKHIQDIGSVLVSVDELLNGIVAEMRLRRELGDYLALVHERDPISRSMKGTFALRAADDSLAELELYLRLSYLGSSVVTEIDKPSSDPFFYAQEETNLGESSRYECRELDTSAVPTSAPGRPIFSAKLECVCTDEQKYALLQPEGTKTQATTTAIVDVGEDDGKKKKKGKKVKKRAKEKGTSTEPETADKAIGTRETKGRRASRETKDKEDKDAGKQQRKELTDAERMRLIRSKRRGGGGGGTVGIVDRSRKTCVVSCSEAAAPACYSADICITKPACLSVCPPAAPEPAAVCCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDC7</accession>
    <name>A0A232EDC7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006703">
        <property type="protein sequence ID" value="OXU16366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDC7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="86" mass="9861" checksum="B71A9D4B5271116A" modified="2017-10-25" version="1">METGEDYYGEPGLTRPPVSYLSFFIQSSTVVLRRNSQARRTTGGQPAPLNRRDPVDDTRTILENLVGMPAEIREAVLRRKYRDQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDG7</accession>
    <name>A0A232EDG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01006567">
        <property type="protein sequence ID" value="OXU16378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDG7"/>
    <dbReference type="STRING" id="543379.A0A232EDG7"/>
    <dbReference type="OrthoDB" id="7700999at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="55458" checksum="8448ABD9BE3B0C18" modified="2017-10-25" version="1" fragment="single">EYLIQQTLNNISEFANKSGFKFSKNKIQVIIFSKKNSIDHKLKLNISNDPVQTVKETLNNISELANKSGFKFSKNKTQAIIFSKKNNIDRKLKLNISNDPVQTVKEVKILGLIFDSRLTWKPHIEHLKRQCILRSNILKTLSARNWGASLQILVNTFKAIIQSKIDYGSIVYGTAKNYITKTLDPILNSCLRISSGAFRTSPINSLIVESNVLTLNLRREKLSTKYTQAIIFSKKNNIDHKLKLNISNDPVQTVKEVKILGLIFDSRLTWKPHIEHLKRQCILRSNILKTLSARNWGVIYGTAKNYITKTLDPILNSCLRISSGAFRTSPINSLIVESNVLPLNLRREKLSTKYILNNISEFANKSGFKFSKNKIQVIIFSKKNSIDHKLKLNISNDPVQTVKEVKILGLIFDSRLTWKPHIEHLKRQCIFRSNILKTLSARNWGASQQILYMEQLKIISLKPWTQFSTPAYEYLQEHLELAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EE31</accession>
    <name>A0A232EE31_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005639">
        <property type="protein sequence ID" value="OXU16605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EE31"/>
    <dbReference type="STRING" id="543379.A0A232EE31"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="8277" checksum="0B34D5D9CD69A6C4" modified="2017-10-25" version="1">MTSPDFYLWGYLKDVVYEHETTTREDMIHRIQTACENIPRAVLLRTVEHFQQRIELCIQQNGGVFEHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEJ1</accession>
    <name>A0A232EEJ1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_008483</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005329">
        <property type="protein sequence ID" value="OXU16748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEJ1"/>
    <dbReference type="STRING" id="543379.A0A232EEJ1"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="15">
        <location>
            <begin position="36"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU16748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="365" mass="40809" checksum="CF0294B7F23F11E1" modified="2017-10-25" version="1">MIPLIHKDSPSIIIRVKEKILGWKRLIWADKNVRNLFLFLILNFSFAFVELTYGIWTNSLGLISDSFHMFFDCTGLIVGLSASVITKWRANERFSYGYVRAEVLGGMVNGLFLVFVAFFIMSEAVERAIEPPEVKHERLFLVSVLGLLVNIIGIFAFNHGHGGDSCSHGHGHGHSHNHGHSHSHGHSHSHNHGHSHNHHDHAHNHHNIDIDHSHGSSGNSQIMKGVFLHILADTLGSVGVIISAVLMQMFGWMIADPICSMFIAVLIFISVLPLLNESINILMQRQPKSLDHVLPQCYNKVTQLAGVYSVQDPHFWTLCSDIYVGCLKLEVARTVDPKYVVAHTQMIFQAAGVRQLTVQLDYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEQ7</accession>
    <name>A0A232EEQ7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005242">
        <property type="protein sequence ID" value="OXU16840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEQ7"/>
    <dbReference type="OrthoDB" id="7612378at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="164" mass="19020" checksum="11601804F4DBCB50" modified="2017-10-25" version="1">MKRNVALRKLEGGVQVSSIFKQSSAPYLYKFSCELKQYTVPYIILVEKACCSILNNIFINKMDIILDTQRFKGQNGEYIIKELAYIVPSCITFHPPYSWYDLSNDVECANLWLKYSFHGLKWSDGDVPYEKVVEVVPAFWTYHRQEISWLSILKDTRISVSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EF66</accession>
    <name>A0A232EF66_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005127">
        <property type="protein sequence ID" value="OXU16968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EF66"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="11264" checksum="7756D024B2D50FD4" modified="2017-10-25" version="1">MSRTNQRALMHDSLSARTVSKSGVSKKRGPNKLKERVSSRKSGKSASSLPTVDRVRQSMRKLPCSPLFVNLLGGTESQSTALGQRHCVGSIVYFQCNAVKIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFT3</accession>
    <name>A0A232EFT3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_005291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="EMBL" id="NNAY01004941">
        <property type="protein sequence ID" value="OXU17207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFT3"/>
    <dbReference type="STRING" id="543379.A0A232EFT3"/>
    <dbReference type="OrthoDB" id="7863416at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012850583" description="limulus clotting factor C" evidence="12">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="63"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU17207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="310" mass="33959" checksum="A0B1EF3578429298" modified="2017-10-25" version="1">MNLQFKFCAIVFFALVQRSLSMMKAMKDDHSKCGCPAVWQRQPRQLRSHDPDNGAPGRSTGRIFNGKPSRRGSWPWQVSLQLLHPKLGFIGHWCGGVLIDESWVLTAAHCVHNDLFNLPIGALWTAVVGEWELDSGGRGSARLPVERVILHERFENYVHDIALMKLARPAPLSKVVRTICLPTEDEEPRAGLQCVTSGWGRSGPSPSLSSALLEANVPLLELAECLKAYGKSVPIRDGHLCAGNTDGSSGSCVGDSGGPLQCRRPDGVWQLVGVTSFGSGCARPGFPDVYTKIQYYSPWIRDTIANDVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFV9</accession>
    <name>A0A232EFV9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004925">
        <property type="protein sequence ID" value="OXU17233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFV9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="139" mass="16745" checksum="80A3F3B7B1B8C95C" modified="2017-10-25" version="1">MEAEETDSNILNLEQSGKKRTKACILKLTRLDEEPKKKRSKPKKWFILVNNQLNLSIPAETFIGWITWYWKRPAPRKQKKRREQDRIRKMEQRKMLKEETLKIKKARVPLIRNKNTTTFNNPSSTAIHFMHRMQERSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG66</accession>
    <name>A0A232EG66_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_013391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004846">
        <property type="protein sequence ID" value="OXU17346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG66"/>
    <dbReference type="STRING" id="543379.A0A232EG66"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU17346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="343" mass="38849" checksum="44627184024FDCFB" modified="2017-10-25" version="1">MLISSLIQQANEKWFNVQKKTTEGVQSAKDAVFRGGLIIICGILIVWISIFLYTAFYYAYMPSMTHVRPVHLQFKSCDKDKGVCSFPSAYVQLTKKQQLLMVGQPYKVNLQLEMPESPANKELGMFMVCAQLRSRDGVLVKHACRTAMLHYRSTLLHLLMTLTYSPMMIFGTLEEKQSIVLELFGNFEEDQSHPVTIVYVEIQSRHIEFYSATIMINAHLSGLRYLMFHWPILSAIVGIGTNLFFIVLICILSYLHFASEEENANETFNYEKGESEEEKDMILPGDLGSDTSSVEDTSLLDDIPKSQDDSPSLSSTDPVLSKSSYIQEISSLITESTKEELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHZ2</accession>
    <name>A0A232EHZ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_015804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004388">
        <property type="protein sequence ID" value="OXU17965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHZ2"/>
    <dbReference type="STRING" id="543379.A0A232EHZ2"/>
    <dbReference type="OrthoDB" id="8020218at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000055">
        <property type="entry name" value="5-methylcytosine rRNA methyltransferase NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="187"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="294"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU17965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="496" mass="57107" checksum="484EE43183A0F3F8" modified="2017-10-25" version="1">MTRLFKNIKLFNALKIPIRYKHPPHHWSMLKRKKPSTKKALDHFDDFYQSVYGNDWANIRSALLSENHKYIAVVNNFSDTERICEELQALGAMNLKDIYEASKKNLELYQAQGENKDVDVEKLDKNMGDILSEEKMKHSFYPESYQVPRELDNIEREDVSSFKPVQMQSIEKDQYMANDRNRIISSSAGVSASQLFEYVPATKIKGKDDFVLESEHYGYYTQGANFVVKKEEEDFLNFPEKLLLYTFEEGSSMKFPKAKNGNTKVLDYFVLDGASVLPVISLDLQPGDTVLDMCAAPGGKTMTALQTLNARLIIANDIQESRINRINRFMQELLPNIGDWDKRFFITQSDARYIEDKDIYNKILVDVPCTTDRHVLHEDDNNIFKSTRIKERLRLPEIQCDILKNALKIAILGGTVVYSTCSLSPIQNDGVVQMALKKAFEESNVLYVVKDQTRALKPLQFLYNFGDNGLKYGHIVVPSKSRNWGPMYFCKMVRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI27</accession>
    <name>A0A232EI27_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004350">
        <property type="protein sequence ID" value="OXU18019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI27"/>
    <dbReference type="STRING" id="543379.A0A232EI27"/>
    <dbReference type="OrthoDB" id="93876at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06880">
        <property type="entry name" value="PX_SNX22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052467">
        <property type="entry name" value="Sorting_nexin_PX-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813:SF9">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15813">
        <property type="entry name" value="SORTING NEXIN-22 AND 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU18019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="176" mass="20398" checksum="1A1836F705599E4E" modified="2017-10-25" version="1">MERNNSDEMYQVFISGYRLANVSHGKPYYVYTVEMVDSNNGARYLIEKRYSEFNTLHRMLKKDCHTAPFPPKRVRNSNPKVLEQRRAALEIYMQKMLRLASTKQQVLNFLGIDGANSEIYNKGMQKIYKDENIVQCSSLQHHPVLTFQCDPYVHVNETTSLPDIVTNGVLLGIYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI43</accession>
    <name>A0A232EI43_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004352">
        <property type="protein sequence ID" value="OXU18015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI43"/>
    <dbReference type="OrthoDB" id="6600770at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="475" mass="51207" checksum="CE58BE3DA00306BB" modified="2017-10-25" version="1" fragment="single">MDSSYPVPVDICSTIQQCQTLTEENERLQASLRTQPAHVQVIDNVYLQNQVDTLQWQLKQSEANRQMYRSLMEQVVRFLDRARKSLDIIHEKSASKRNGNSHNNSSLKEKSRVPRSRSVHAVHADHNGSPSRCMTASSSCASSTTSSGSSASSTSSSSSRFSRAKSVAQISGNGSSGTTSGLRDFTWSVLRRNDPVQCTPPRTKPPPPPVPQASVSVQDVNKTQDSVVYRRPKQSELDPDDVPPEKLSQEAFRLMRTVQSLLVMREPDLARLGSSQEVNGGISPLPLDQHPSNMSSLSLHSNFANSTALQQDISSTSTTATTLSGSSSSEGRGTDGSCCTDDEINRTIFGGANNPSSKLASNGSSANVSTTTLMSPGARQSIDATSLNSASSKNTEDDDCVSSSRNSNLSGLARKQDSGCALQQNGYHVQAPTSTPHNRRLKKLDRKELHLKSLRDWALGNSSSSVTSRPKPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIF4</accession>
    <name>A0A232EIF4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004243">
        <property type="protein sequence ID" value="OXU18157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIF4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10536" checksum="F272D66FF3C95619" modified="2017-10-25" version="1" fragment="single">SRASNPTVVGSCAKFSEFRGHAHREQRHHSSFLLPAENLNGHSRRFPRREERVGRRARAAGHLSGVQSGDRQRRQCGVDDRPVPAVGNKQIRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EII8</accession>
    <name>A0A232EII8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004219">
        <property type="protein sequence ID" value="OXU18180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EII8"/>
    <dbReference type="OrthoDB" id="8188638at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28274" checksum="85D92D16B7D18AE3" modified="2017-10-25" version="1">MYLTNLGQIDKYQDTRSLVKDVVDKLALTHNKVLESEKSKLKLKQSSEQGGPNTSNVKVRPKFQRNYKLTSKASFEVWMNKGERVHTFCDRFDQIIREHELSDDPEKLTEQEKRSTFYQAVIAVMPEIRRIDSAVITTTGKEMNMDALRKVMIRIQEDNDADSKKPESKEPIASRASSKKFRGDKNKCFRCNKTGHWQQDSPLTNPNRWFCYLCNCETDHKEDDCPSKFNQGSQGQNKSQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIK9</accession>
    <name>A0A232EIK9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004225">
        <property type="protein sequence ID" value="OXU18174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIK9"/>
    <dbReference type="STRING" id="543379.A0A232EIK9"/>
    <dbReference type="OrthoDB" id="7994850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="226" mass="25655" checksum="94FB38116A3249A4" modified="2017-10-25" version="1">MFKFSTATTTDSTSVSAAASAPTSHVAAVEKIKLPTFDGKHSEWDSFKGKFTALIISDTQMAPVLKLQRLYNCLEGEALSIIRGIKSSADTFDAAWNKLLRQYDNKQVRFSKQMELLINLPVVQEESVQCLNLALVTIDESTNVFTSLERPVKHWDDIFIHCVKASPTHFGIEDLETRLEMLEELWREFAARDTILKRSSEQLKGRTYFKEDMFVGTATRYMDAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIW5</accession>
    <name>A0A232EIW5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004142">
        <property type="protein sequence ID" value="OXU18309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIW5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="132" mass="15343" checksum="3BD39AD9D31C33C1" modified="2017-10-25" version="1">MAWPINMKFECYIALIVSTKKSGLLTVDPWIDEDSEEFFGTDVEDEINDDGDIFHDSDDNNYDWVNNFEADDTPEEITFEKLRNLCNSDEGNAKIEGLVTVLHKRLRNYDDLEDFSDGTFYKKFIKSLPLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIZ2</accession>
    <name>A0A232EIZ2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004122">
        <property type="protein sequence ID" value="OXU18339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIZ2"/>
    <dbReference type="OrthoDB" id="7648950at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="156" mass="17597" checksum="69BF5D55BD892969" modified="2017-10-25" version="1">MCLMWSKDLIDAHQVNIVPNKIIHLDGAHCKASKFPKILEQAGYLALEIIIQNSTIIRYFGMHGVDQFVLIIPPIRDVDFETIIDTEGKILNIANFQPLALTKGTAVNVIGEINLSTGLLTINCQNSSDVQLREDIEPLTDQQLRRGTRIHKRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJS2</accession>
    <name>A0A232EJS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_000264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003958">
        <property type="protein sequence ID" value="OXU18578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJS2"/>
    <dbReference type="STRING" id="543379.A0A232EJS2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="165" mass="19168" checksum="20B74B33DCDA18D2" modified="2017-10-25" version="1">MMSRKRTSQSVSSDSEVETSEDDETILIPNADDSGSSDDSDSDYDADIHCNETVPRVTYQQVSKSYEADQAKLENDYEFDWIDAMPRSKFEKIKSKLKYSKAKDNNPNDKAWRDRELMKIFQKNILKFGFWRTALSVDEMMAKSYAKTSLKQFIRGKPIRFGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK34</accession>
    <name>A0A232EK34_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003883">
        <property type="protein sequence ID" value="OXU18717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK34"/>
    <dbReference type="STRING" id="543379.A0A232EK34"/>
    <dbReference type="OrthoDB" id="2359033at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18493">
        <property type="entry name" value="BACK_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18292">
        <property type="entry name" value="BTB_POZ_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056184">
        <property type="entry name" value="TRAF_BTBD17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF41">
        <property type="entry name" value="HL07962P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23651">
        <property type="entry name" value="TRAF_BTBD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="165"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="615" mass="71446" checksum="DDB400FFBD2C0F27" modified="2017-10-25" version="1">MDNIRENKQIKENSLPDKSSKWNKPNEEKTNIIENMMFLRKRRRLICLIPNERELFHLKLILHRVKGATSFDDLKNYENKTYSTFTATAIVMGLIVKDEEIFCILDEACTIMLPNQWRLFFAWFLIVNKLPLAQIVWKKYKNFFVDNSRTVLMKIATLYAERLMNDICLVVNDVEYPAHRLILCASSDVFEVMLMSPQWSESQESRVALQETPQCATIFSEFLRYFYTGHIGFSNEIVLPILSLADKYNVRDLIASCLNFMRDHIPVAAIHGTLVSWFQYSLNCGHNEITNACHNFVKWNIELVAATPDFANFELDVLVSLLHQSSLVIYDELSLFKYLEIWLNHQNDRLKSQLPITDVETTLKQMVIAVMIPIRFPMMSPRQLAELLLSPLTQKYKEFFVERMAIGMSFHSGHNERVRNIIKTEDNGLLLFEPRLYTVDTCSSLLTVENFHSLLSYHTRTLVFSSHSHLADYAGDKTCEWVVDLYPKGVWFKKFFLIVWQGTVEMPEHVIRSVRLSLTCKDPPSDSDLDMRVKIGVLIYGIQDDVEHIARVKEVIYRFNSNDRILNLDNILPFEELNPLQDSINSNTVVSKYLLGPNKDTLKLHIVISPINSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKF2</accession>
    <name>A0A232EKF2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_013276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003821">
        <property type="protein sequence ID" value="OXU18798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKF2"/>
    <dbReference type="STRING" id="543379.A0A232EKF2"/>
    <dbReference type="OrthoDB" id="5951542at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="348" mass="39834" checksum="0034A97F72810E0F" modified="2017-10-25" version="1">MSIEFDPVRLMNNIDKSCINCTETNCCCSDNNQIPEWTWDQSFETPKLQLGKRNMEVKFHPGYSVGTAGIRGNKPLSRNRHHYWEIKMITGVYGTDVMVGVGTKKADLTSTTESFCSLLGRDAESWGYSYRGYLQHNGQTKEYTACFKLGSLVGVYLDTWKGTLQFYLDRKPLGIAFTGLRGLELYPMICSTAAKSKMKLTCSCSMPASLQLDCLSMLRPIQRAYLKTAFPGLNYLSRSIFADLLQKCDDDDNEEDYEFPRMILEDFDFALVQCKNRRKKRHIDQDYISELPTSSLKTIALTTKEDFENDENYHQFCVPNLFFSAFEMGRFLLVLLLVELILTQNTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKK1</accession>
    <name>A0A232EKK1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003761">
        <property type="protein sequence ID" value="OXU18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKK1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="7929" checksum="07F86F9E151C8A4E" modified="2017-10-25" version="1">MTVGGAQALFHFSHSNMRSESRYSGGPPMLKLPDFSVFKRLKCQGANASQTLSPWLTTGPGKVNDCNNSRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL23</accession>
    <name>A0A232EL23_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_000320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01003660">
        <property type="protein sequence ID" value="OXU19045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EL23"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000342">
        <property type="entry name" value="Serine/threonine-protein kinase VPS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1036"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1383"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="927"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1354"/>
            <end position="1369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU19045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1413" mass="158451" checksum="88ECCEA36AC1EFF3" modified="2017-10-25" version="1">MGNQLVGIAPSQIFPVEHYLTDHSDLRFDVSLGSTRFFKVARARSQEGLIVVKVFAIHDPTLPLSTYKDKLEEIRSKLASAVNCLPFQRMILTEKAGFIMREYVKYSLYDRISTRPFLSSIEKKWITFQVLYALHQAHKFGVCHGDIKLENIMITSWNWVLLTDFASFKPTYLPEDNPADFSYFFDTSRRRTCYIAPERFVKTLTSEPNNTLLFQELKTGDLHPMMDIFSAGCALTELYNEGHPPFDFSQLLAYRNGDYSASKHLDNIEDEGIREILASMIEKNPSNRKSAELYLSQARGKVFPEYFYGFLQSYMQIFSAAPILSPDEKISRLKKDIGNITSMFHEEIQERRQSVEMSKSKEESGHAEENTVIKNDSDQSLEKIEVDIKDAPKLDSLDSPADGEKEKVKESKAAVENVDTEEGLVIITQLVTSCIRGLHHSQSKLQSLEILLELAENTSDETILDRILPYIFHLVHDPAPRVRVSAIHTLTKCLYLVKTIPPSDVNIFPEYILPGLAHLTQDEAVIVRAAYAENIAHLAHIALRYLENSHLSTVESKETQRPSYDSELQALHEMVQQSVSMLLTDQQNLVKQTLMENGINKLCVFFGKQKANDVLLSHVITFLNDKEDKQLRGSFFECIVDVAAYVGWHCSPILMPLLQQGLTDPEEFVTTKAISAMATLTELGLLHKSALYQLLSETVVFLVHPNLWIRHATVGFISAAARTLNIVDVQCKVQPMIQPYLKHPLIQIEKEVLLLEALVTPIPRVVLDSVIKYNDIEELFHVFEQRQVARAKAVTGIVPQYNDMSTALRNLFRRLSSETMTETVEDQLLVMKPHLLKINKYRQSAESKQQPSPVDGKLELGPLKHKISHHVVVLYPDTKSDIGLPSFKKLDRRTSDSTATYASMNQEWRTMFAAQDNIQHSAVKISDMSASGGSPSQSIHGGDIHLSPQHSLTDTTNSINDHSLHERSYIQFATLYGFADRCAPCRLELRQLSYRKQEQHASAVRAQHWADNIAWQAGSRLLPSGWRPRGVLIAYLHEHRAAVNRLVSVPDTSLFASSSADSCIKIWDASKMEGRNLANRSRQTYMHRGGPLVGLVVCEQGQSLASTASQSGTVFVLRIESNSSKMNVLYSRQLDMQEEGCAVDLQYLDSGSQSVLVYATLYGSLIGWDLRCPGTAWRLENDLKHGVITSFCINNHQQWLTLGTSSGVHICWDLRFQLPISNIKHPTGARVRKVITHPTEHSWIISAVQGNNEISMWNLETGFRQMVLWASSAPPLSHSQGGHSVCAMHSACIDRSGFLLASGSDMRLRFWNLHTPNESYVVLPATNDSLALNSLAYEQRLIDGTNVVQEVLASGTSGPSSSGSSSMRSRGIEEGGPGPEMPHPGHHDTISAVAMSNTCILTGSTDGLVQVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM28</accession>
    <name>A0A232EM28_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003453">
        <property type="protein sequence ID" value="OXU19391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM28"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="13520" checksum="3D322758D4509665" modified="2017-10-25" version="1">MFSQDYRNVTIMVDLAVREEAIHNLKLAFRQLRVISGHSIPENFTTLGPYVEDLYEKFQDVNEAILAVKTLKEIPSTMNENKLIRNRLRKDVYEISKAQIFEKDGGIFAESAISKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN43</accession>
    <name>A0A232EN43_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003244">
        <property type="protein sequence ID" value="OXU19742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN43"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="7778" checksum="DF6E02F779C6D40B" modified="2017-10-25" version="1">MTGNNDILYAVSRWSAFQTPGVYSGQHIAKLVLVKALVFPYLDYCGSLFLSLTQELTTKFERYAGLQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENW0</accession>
    <name>A0A232ENW0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003055">
        <property type="protein sequence ID" value="OXU20045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENW0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8128" checksum="E3FA102DAECF9636" modified="2017-10-25" version="1">MTHEMNTEYTCNNELVNLANVHQGAEKNGLLGTLAYLQNIESTSPPYMALLINPRSSNNSDSTGIVFQEKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQE1</accession>
    <name>A0A232EQE1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec16 Sec23-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_004397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002781">
        <property type="protein sequence ID" value="OXU20570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EQE1"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="7">
        <location>
            <begin position="1570"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1349"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1525"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1886"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1977"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2068"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2227"/>
            <end position="2284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2316"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2371"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="916"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1120"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1262"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1548"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1886"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1934"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1991"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2021"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2041"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2068"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2079"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2373"/>
            <end position="2385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2386"/>
            <end position="2400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2408"/>
            <end position="2418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU20570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2444" mass="275593" checksum="B06D509F209782AA" modified="2017-10-25" version="1" fragment="single">NPYRVRPTRSRVDPSISGYGVHNQKPWNPGPAQRPPSVDPNATFQPPPLANPTKQVEDSWDWNVDNGNGNGNDSWNWSIEQSEAQAQQHHQQQPQQQPLQNQFIPPYTNQKQSIPPPNQENYYKNLNGNNKAAGPPINQYGPTSRETPRTAPPVREPTPKQPDSFPQYTNYSHNQQVSTPPRPSSNTSYTGSVDQSQWHNEQHSQSLPFAPPSQVHNQKPPQHQAHPTSPPQQQTHPTPPPQHHTHPTPPLSQHQIHPIPPPQQHAHQTPPLSQHSTHQNHPPPSSVNNYNWSITDQQQSAPMHNWQQQNHGEIPASSYWQEPTPAKQDHFSENRSNQWPQQSQQASHQFQQRVPHAYPSSNAINNDHPKFYNPHESSQENKPAQNWLPQNALMSNQWSKSNSENVTNVLPRQQSLPSNTWSQAEEANSLPSWQQGGTGGNIPNSQWRQPKLQPGGSLEESALSENNKGDWHQVHAPPSHFNSSTTSTTSGSLANMSSSTEQLEDRKRSLTPTTSCASLNEFQTQTSNANQVNAENSAASNVESFHPQSNVDLDWGAEAEWNTVTEVTSSIKNMSLNPQYNQHVENEPPRKDEQPAAHAVNDWGRQPIPGLKSENIENTPENVPILTQERNSVESQAVVSQEQYETHQASSSKFSENVAQAANYDQWYKQNVRTQPENEFFGGDRALGAVKQWQPEQNVENYENIQQPSEFVNLEVVAPELQERDIYGSRDSINKETLDNDQGLRQTATPKETVMRDFRQEVSNVEVPTVQQIQQPILTEQAPDNYEFASNDRNTFLETGELTDPHSQEHEPIPPSQDDENDEVPNDIPFLREVPGQSSSVDPRRNDPTGQEQYTLGPRMSDPRRNDPSGQEQQQTVAPTRPNILADRTTDRRDVPSGQERVKPVSQPPLPQQRNSDLETVERRNDPSGRERSLPPPQQSRNEPSGEEQRTASIVLQSNQLEPGAVREIPGRGNEPEETIQQPNSDIRQIPGGASSNESVQIMPDDRTTGVARVVTGLQQSNISSSLSVAQDSSSDNRSKREEAVGASVAESQAGSGPPNRRDSYEDGDDEGSGNSREGSRDRCRDSSPKPRHPRYDRERDFDDDYYYDRRRGTNYAYNSREDLDRRDTSYRDDDRRLTSRDIETERLLVRDELNRREDIDDRDGRRRLDDRRLDRSADPRRLDREPREFDSRYPRDPRDPRDPRDPRDPRDRDYLDSDRGRRREDPRRPRRYPDYDPRDNRDQRDPREAFRRDYYDDLYARNSRPSSRSSYNDRERDFYVRPRDPYSSYGYNSYQGYDYGSNYNSNYYAYLENLRRTDPAAYAEWYHKYYQQQQQLTRGVAATYPEDRASVHSGRSSCDDRNSSDKRNLTDVSLMEDQTTASARLTPTKFSTAHTKGSFSIGSILHVHASYPTDGERARVDILKVDNLIPHDATLRELRYYPGPLIKGVTHKKTIIEYCENKIKKASTNEDIFEVSSYVLLYELMIMLIQQNGNVVGVDIASLLLRNKEAYPYDVSKPLKENIRRESTISQRSGASGGDRSTAEAVQSHEKEEQLKPRKTVEQLTDEFRNTLLYGLVQEALEFAMVEGLWGHALFLASKLDKRTHASVMARFANSLPPQDPLQTLYQLHSGRVPASVTCVSDSKWDDWRPHLAMIISNTSTNPEINRRSVSNLGDTLAARGDIYAAHFCYILSQADFGSYGSGNNVKLVLIGANHHKPYSEFLSTEAIMLTEIYEYAQKLSGSESFTLVELQTFKFNMAVRMVDYGLIEKALLYIEQVSTNIVSEPEKYKQSFINDVYVLGDRLKYHDPICKDSEEDVANLVWLNNLSEIVGKCAKGEIVQENNYYAPAPLTVDTTMDPPGNQKRWGMQNEYNTENIASTLMTVPDQDNYNMPNSANSEKAPEEKAPATESKASGAAEVSSPACHLTNTPTKHSSRSSLRQRRRQPSDDVTLPKLSLLLSAEELATGVKYPKLGSRYPRIPPTNEIRSKLPTNPKLSTGTPCAKPSEFLKCPVKKRNASDDEEPDDEDVEEEDEEEVEEQKEKDVEKDIALKRKPTTDLDIQFQQMKLDNLAPSTTKTSEERRKKPSNESGQTLVQYCNFEEKKVVKVAPHIRRKDVICDTVDAWSRRRRDSEEQLVVGWDRPRYRPLIFGGTYPIDAPFAEDARKDLLDGRSISKTFDIDAPTGGSWFGGLFSKLAPKPKNQMILPDDSNPAIVWDPVAKKWTNKEEEDGGGAAPLAPPPKMSELPGFKPAAQTPAAIPQNAPVGPPSLGGEAPANPADETLGGLNASKMIAGGGGNMYKLAKNRSTRAKYIDVMNPGGNKAGGTGAAPPPAPLAVPTPVGSPAMPMAASSPQYFMPAPVNDPNAPVNFLTPLSNAAPQTNENSQALSRWSSTSSLSREVQSYTMRDPRLLQRDKGPMMYNPVNLKDRSQKTTQVRSRYPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERG6</accession>
    <name>A0A232ERG6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002599">
        <property type="protein sequence ID" value="OXU20963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERG6"/>
    <dbReference type="STRING" id="543379.A0A232ERG6"/>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="155"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="342"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46919" checksum="E3F886F73C5DC267" modified="2017-10-25" version="1" fragment="single">SGSPRRVSTGQQQQQEASGATNNTTSATNTTNSSSGQQQQQQGNNHHHHHHLHHSSNHHHHHHHHHLYTASTNVRHTRNKLPITKQCSEHRHHPTRSHYRGHRGMNMGQKISGSVKSVSRESGAGAGGGVGGIGGGAAAYKSVVPRELAQDFSRPARLDVLLDMPPASRETQVHHSWNADDRSLNIFVKDDDKLTFHRHPVAQSTDCIRGKVGYTKGLHVWELHWSTRQRGTHAVVGVATADAPLHSVGYQSLVGNNELSWGWDLGRNKLYHDSKNNNGITYPALLKPEESFIVPDKFLVVLDMDEGTLAFVVEGQYLGVAFRGLKGRKLYPIVSAVWGHCEITMKYIGGLDPEPLPLMDLCRRVIRQRIGKERLEDKINELNLPLAMKTYLLYRDRRRHINYDHDYYDYNNHATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERP7</accession>
    <name>A0A232ERP7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_010717</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="EMBL" id="NNAY01002596">
        <property type="protein sequence ID" value="OXU20966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERP7"/>
    <dbReference type="STRING" id="543379.A0A232ERP7"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA01020"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="17">
        <location>
            <begin position="65"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU20966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="405" mass="46357" checksum="DE93A23C979FD423" modified="2017-10-25" version="1">MIVEFCTACALAAFVTLVYLCFFYKINWIRDLTDTDPKSSSLMAKYRTNVNQTLKNLPPVYPNGWFGLLESSSLENGQIEHVAALGQNFAVFRTESGVVRVVDAFCPHLGANMAEGGKVIGEDLECHFHSWRFCGETGKCTTIPYTKTVPSNIKAKVWESIEANGSIFVWHHAENVAPYWWPQKEEAIAKHSLLYQGRNEYYVNCHIQDIPENGADWAHLGAIHGPAMLPTDMFTKIMHHRWTNISWSTTSQNEATADDSEEQNKEKHIAYLTLHHDLILFDKFSILTLKVKGRQVGPGCVEINLESALGPMFIVQTVTPVQPLVHRVTHTMYASRFASFYSKIVFIGECIMFERDVRVWNHKKFMHNPALVKEDRTIKAFRKWYQQFYSENSPTYESCKASLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERU2</accession>
    <name>A0A232ERU2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14 8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="NNAY01002550">
        <property type="protein sequence ID" value="OXU21075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERU2"/>
    <dbReference type="SMR" id="A0A232ERU2"/>
    <dbReference type="STRING" id="543379.A0A232ERU2"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="10">
        <location>
            <begin position="411"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU21075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="610" mass="68528" checksum="9F3443AA0343B6DC" modified="2017-10-25" version="1">MYALQMQNACQGEGDGEPQPDPCSQNPEPAPTTTQDCSNFDIVRATQYGALDRVTELVEAGADVNQPDAETVTLLHWAAINNRKEIVKYLIAKGATVDAIGGELASTPLHWATRQGHLATVVILMRAGADPTLRDCEGSSCIHLAAQFGHTAIVAYLVAKGVNPNMPDRSAMTPLMWSAYKINSLDPTRLLLTLGASHSLTDNLHGNTALHWAIIAKNNTAIKTLVHYGASLDVPNFKNETPMMLLGPHIGAAWLGHKFSHEIRQKQGRTRVWCRDKRIRWYCMISTPFIIFYAIGMIFQSGLDYLIKLVAFVALYIAIHTASNYIYDERLYYVLPMSIYLATKMWIYVTWVFWLGIHAAWYLWLLLVGGSVPLWICFLQSWRGDPGVIKASHEDKLNCIIELAENGGFEPQLFCHTCLVRKPIRSKHCSVCDVCVARYDHHCPWVNNCIGARNHKYFLGFLMSLLGLCIVVLTASIQYWQFECWTNLTDGHTADNYLIAAATCDAWIMWVTTNTALHSFWVGTLLACQCYQIMILGMTTNERINAGRYKHFSKGNPFHRGALQNAADFCDCSFCGLKAKPSTDWLHSYDLKQSVEKLPLLSQKDNYQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES29</accession>
    <name>A0A232ES29_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 35 member F6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002506">
        <property type="protein sequence ID" value="OXU21170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES29"/>
    <dbReference type="STRING" id="543379.A0A232ES29"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU21170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42081" checksum="2E2A89B6AA6EEC6C" modified="2017-10-25" version="1">MGWTHYQKGLAIMMVVTGSFNTLSVKYADRQVVAGYDGELRHFTHPFMQSSFMFIGEMMCLLVFKLAFCYYSRLGNGTVDTSNLTKGSRTFSPLILFIPAACDMTATSMNYIGLNMTYASSFQMLRGAVIVFTGLLSLGFLNKKMGTREWTGIIFVILGLLLVGLSDFITMKDQKVNTNSVLTGDLLIITAQIITAVQMVVEEKYVAGQDIPPLQAVGWEGFFGFIGIGLLMIPFNYISASPPFADNTRGTLEDTVDAFVQIGNSGRLLMAIIGIMLSIAFFNFAGISVTKELSATTRMILDSVRTIVIWAFSLAFQWQKFHYLQLIGFSILFIGMSCYNNVVIPQLVRKCQCRLGRHNPPADEERVVNTAADDLEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETJ7</accession>
    <name>A0A232ETJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_009807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002283">
        <property type="protein sequence ID" value="OXU21626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETJ7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU21626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="369" mass="41579" checksum="14D35B99C050DF9C" modified="2017-10-25" version="1">MHNNEYAQTGKPPTDDSAVSKSSVIETNGSIAKTSESNEECNDYSSFEDLLNIDNFITMENNTLDVISNAFHELTTSSINFDQENNMSTISGTGVDGQSDGSLNTLENPANNNLNVSSLSDVSLALKGPNFIVEVGNKSDGQCKVKIDSNTYSINAHVQMTNFEASGSLIPNLNSIEHSNGTSTVPVAKSTITSMAQKKYFPKFIKLYCAKCGESSWTPRYYSDQKCPTCENKVTLRCCKCKQESDKYENMVYHLKTKCAPNDVKYKCSQCDYNTFLRSSMRYHLKSHEPSNNIKCPDCGISVLKNKKCLENHQRYSCPNRQQEGYMKCSHCYKKYRNEICFQKHEKNCIYNRDREEERLDDGSSHANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETU6</accession>
    <name>A0A232ETU6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002220">
        <property type="protein sequence ID" value="OXU21779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETU6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="8021" checksum="59226A0B30882FF0" modified="2017-10-25" version="1">MCWLEKIKVFDQAEIKNERKALGFSEVEIENLRNREGPVLEKMIARDKDMAKQNVNNKVRKAKYNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETY8</accession>
    <name>A0A232ETY8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Outer dense fiber protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002197">
        <property type="protein sequence ID" value="OXU21829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETY8"/>
    <dbReference type="OrthoDB" id="406368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF28">
        <property type="entry name" value="BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="28"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="979" mass="105984" checksum="031C9282428AE9C9" modified="2017-10-25" version="1">MGGLTQRPWTPTKRRGPIAAEFVTPGPACVTLPPLIGKTMTDSKKGRAPAFSFGSRHSNKNDSPGPGPGQYNISGLSAKGKDVAPALSLHGRTKSGKIETTPAPGDYDPQKAEKIISDNSPKFSFGIKTQIEKVNHTPAPGDYNAIVKLDHSGPEFSFGMKHVVDKPSEIPAPGSYCPEKVRLDNSPQYSFGHRTAIEKPSDTPAPGTYCPEKVNLNKGPQFSLSGKNYVEKPDDKPAPGTYSPEKFVHDKSPQYSFGRRTSVDQLSDTPAPGTYCPEKVNLDKGPQYSISGKNHVDKTDDRPAPGTYSPEKCSLDHSPQYSFGRRTSVEKLSDTPAPGTYSPEKVNLDKGPQYSISGKHHVDKPDDKPAPGTYSPELHDKGPQYSFGRRPSFDRVSDTPAPGAYCPEKVNLDKGPQFSISGKGLAEKPNDLPAPGAYCPEKCNLNKSPEYSFGLKVSHDKPSDTPAPGAYCPEKVNLDKGPQYSLSGKGPSEKPNDVPAPGTYCPEKVNLNHTPQYSFGVKHSTDKPSDTPAPGVYSPEKVNLNKGPQYSLSGKASPEKPNTNPAPGSYAPEKVNLHKGPEYTLSGRARYEKPSDTPAPDAYCPEKVNLDKGPKFSISGKHQSEKPTDSPAPGTYSPEKVNLDKGPQFSISGKAPFEKPNNNPGPAHYFPERVKNLEHIPHYSFGNRKPLHKINNFPAPGTYSPEKINLDKSPQYTFGIKAQAEKPNDIPAPGTYCPERVIIDSSPQYSFGRRTSLDKTDNIPAPGTYSPEKVRLDKGPSYSLSGKHHLEKPNDVPAPGAYSPENVKLDNTPQYSFGLKVESLDRNNIPGPGQYCPEKAMSILQTAYSYSFGLKTSITDTENIPAPNVYNIPSSLGGTKESNIKTAPAFSISGRQKVFTDDRVLVPGPGSYESIKSDAVRSKSPAYSISARYQTPNDHSQIPGPGAHCPEKVVLDVPPAHTFGIRHSPYICNLKDAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUI7</accession>
    <name>A0A232EUI7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_012508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01002117">
        <property type="protein sequence ID" value="OXU22029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUI7"/>
    <dbReference type="STRING" id="543379.A0A232EUI7"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025848">
        <property type="entry name" value="MT-A70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51563">
        <property type="entry name" value="SAM_MTA70L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="554" mass="62664" checksum="7A6894CD2A7AEA57" modified="2017-10-25" version="1">MSDAFEEIQAIKIKRNCLREKLQKRKRERHELFTLTAGASLSSSPNSEPLRSPGPTTSVSSNHAEYEQDVLCILHETHANLPITSAEILDQLRKNLNADVSHAEINKILEKLSSQEVVRIKEVTEDGVFGYTILSFAEAQPLHAQCLPDIIENAESTESTTSETSDNPPPDKQMKLDTKSTEDIMSLILMPTIREKENKKVGEQILDLLSKQTSKEKSLAERFRSQGGAQVMEFCPHGTRVDCAKLNQGFANKCKKLHFKKIIQAHTDESLGDCSFLNTCFHMDTCKYVHYEVDGSTTQQQQNNVTIDETTMNNGNLDKHAANLNIPENPSTLANKNSTELTLYPPQWIQCDLRYLDMTVLGKFAVIMADPPWDIHMELPYGTMSDDEMRQLGIPALQDEGLLFLWVTGRAMELGRECLQLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPRINRGLDSDVIVAEVRATSHKPDEIYGIIERMSPGTRKIELFGRPHNVQPNWITLGNQVDGVHLIDPQLIKAFKKRYPDGNSMKPTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUY2</accession>
    <name>A0A232EUY2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation. Plays a role in neuronal migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002072">
        <property type="protein sequence ID" value="OXU22162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUY2"/>
    <dbReference type="STRING" id="543379.A0A232EUY2"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000002">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="10">
        <location>
            <begin position="195"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="10">
        <location>
            <begin position="282"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="9">
        <location>
            <begin position="443"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="800" mass="92049" checksum="F7B8E63ABB5908EB" modified="2017-10-25" version="1">MSEFKLHHLVVELIELLGSTSAPEKHVERLQKEGATTNPVALNTVATQSCVRQLAKNSPNPELFIKKYEELLSKKVDLLGPFMQLLEFISIDRELKTYLAKNSTPLVGTTSKSATITNEDLPKIFKNVIKAVVEGEKKLNKQVCPVNKQNDAMLMRHTWSTERPRLSWDFQTDATVSLMQKVVPSVSQESILLWDILQCLKGIDGSYIVSEPLTSPYSPITFKISPDVGISFKQLAQQILPLASYYSMTVRFVEEKVLPDDGQVNHALRGALSCLLRDYLASARGGKVLSLLHEQINNMSGEAKCKELCLFLIKAASVPYMQTLEKWVYKGVICDPYHEFFVEDNELIQREELPIDYSADYWEKRYTMRPERIPVFLSEHAQTILRTGKYFNVIRQCGKTVQWGKQEPLVYQHRDQKFIAAIDRAYSEAARTLLEVLIQENDLMGRLRSVKNYFLLAQGDFVVQFMNLCEAELSKNMYDIVTHRLSSLLEVALRMSTADFDPYKDDLKPELLPYDLQYQMFRILSIQTTEEKDYCSQADKTLTGLEAFVFNYDVKWPVSLVINRKAIACYQMLFRHLFYCKHVERLLCRVWISNKIAKTFTHEAAMAYRQAFSVRQRMLDCIQHLEYYMMVEVIEPNWLTFLNKMSKVSNVDDVLSVHQDLQDSYLKECMLTDPELLACITGICAVCIEFCKFMQRMSRYFIDAELTSMIDAGQDDVFEPESECSGNSSAEGASFEEKIVLLDNRFTDVLIRLLNRICDLGCDNSNEKLLNVVCRLDFNLFYTQVLVQRDSEKRTQDVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW27</accession>
    <name>A0A232EW27_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001921">
        <property type="protein sequence ID" value="OXU22565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW27"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="7461" checksum="012758E596BA8BFD" modified="2017-10-25" version="1">MRRECQRWRARIHLGIARIHLYMPARSATSPFSQLHSRTLLSTCGKVVLCERKCMRKFELCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWE8</accession>
    <name>A0A232EWE8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_008552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001874">
        <property type="protein sequence ID" value="OXU22670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWE8"/>
    <dbReference type="STRING" id="543379.A0A232EWE8"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF15">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="360" mass="40236" checksum="2E5BB30A338EA766" modified="2017-10-25" version="1">MSNASAGYNFTCGSGVDSFHTSYVAIHGWASLLVCIFGSIANGLNIAVLTRREMSSPTNAILTGLAVADMLVMIEYIPYAVHSYLYHRPKRETYTYAWTVFVLFHSNFAQVFHTISIWLTVTLAVWRYIAVAHPQKNREWCSYNRTIMAIVAAYVICPLICFPLYVTTEVTSKNVTLDANDRQINLTGNGSSHYYIGGSGADANNATLYFVALTESAQNGLKEMNFWMYSVVIKLIPCVALTILSLRLIMALVEAKKRRKKLTSTTMLKMEESINLAESKKRKRKASRMMDKEKQTDRTTKMLLAVLLLFLLTEFPQGTLGLLSVVLGPDFFNTCYVKLGKLIFLPRSSSDISPAPYSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWN1</accession>
    <name>A0A232EWN1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory subunit 21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_011866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001838">
        <property type="protein sequence ID" value="OXU22753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWN1"/>
    <dbReference type="STRING" id="543379.A0A232EWN1"/>
    <dbReference type="OrthoDB" id="5566667at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040024">
        <property type="entry name" value="PPP1R21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049372">
        <property type="entry name" value="PPP1R21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019343">
        <property type="entry name" value="PPP1R21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448">
        <property type="entry name" value="SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10205">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21636">
        <property type="entry name" value="PPP1R21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01254">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 21 N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU22753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="532" mass="61616" checksum="1478961C4B37F4EE" modified="2017-10-25" version="1">MDSSTSQLQIKYQKLATEYSKIRAQANVLKKAVIDEQTRNTELREQLKEKEVELRRAEQELDSLTFRNQQLTKRVTVLQEDLDKAQSKTKKGKNKATENKAQLPPPPPNHILDEEFQKKIVENAQLQSQISDKNNEIEGLLDRVQHLEYKLELSERAKVELDSKYREILEKLERERNDAQRKLNEKLKAEETVSWSSGEGKRDGYDLELKSGLTSHRQDHSPFSSPSASRRSSKSTVEIGPPRKAWSSAQDENSEDFEFTKLCELEKELNHWKAQYNIVKIKYDEQSHKENSEKRILETNGLEPIEVNNMIGRLIGPFAIPEEIEARETRIREYFLREIDRLITEKHICHVRNLAIAANTEVMNVHLDTSEEQREKCEAALLEALSKWKSLQEDKEVQEGNYKLQLSTMSEHLANMNEKLIHQTEEIQQLKFELSTKSTLMAKLAPQLHPCSAKGLSVILNAERINSLSLIRISSSQALLATLVDEFRNLKSEAEIHGVLLKTYAKSREKYWFEEKLEESPQTERVNFAMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX88</accession>
    <name>A0A232EX88_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001762">
        <property type="protein sequence ID" value="OXU22992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX88"/>
    <dbReference type="OrthoDB" id="7694315at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="65" mass="7310" checksum="E4644E8D5BF07FAC" modified="2017-10-25" version="1">MQVMAKRKSGGGVQVIKKTIADRVRWIDMDNAFKNCMKTVVIANLTHIDVLKFLQDASILFSRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY13</accession>
    <name>A0A232EY13_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_004067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001710">
        <property type="protein sequence ID" value="OXU23160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY13"/>
    <dbReference type="OrthoDB" id="6740702at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="236" mass="27082" checksum="359F6E530661E73A" modified="2017-10-25" version="1">MELVIRDIYSYIISLCNENDMIGVSVRSLNFARGGLSLRLVLNFFYNDLWNLISGLAQSNEDFQIYESFILTLTFINIPNGGRGGKITIIKCLPRALIVGEAFMTYKKFFSIEAIDIWNIVRDRRRGMQKERASLLTINANVVIPANGGEPLFYDGRPLLNSNSFDVINLLYDVRRRHFDTILNLTGAARKRFFCEHCNKSYRYVDEHRCTAKCDRCFCAPSCNSNIDIIKCVECN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY15</accession>
    <name>A0A232EY15_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001634">
        <property type="protein sequence ID" value="OXU23366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY15"/>
    <dbReference type="STRING" id="543379.A0A232EY15"/>
    <dbReference type="OrthoDB" id="8755372at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027917">
        <property type="entry name" value="MITRAC7/Phoenixin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15061">
        <property type="entry name" value="MITRAC7_Phoenixin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6423" checksum="D9F8EAA52B74BC2B" modified="2017-10-25" version="1">MAARLKGWRYVAFLGTFAGSICTFLYFTAVRPMIDPEPYKKIREQVLPKLPKSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYF0</accession>
    <name>A0A232EYF0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein spire</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001650">
        <property type="protein sequence ID" value="OXU23320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYF0"/>
    <dbReference type="STRING" id="543379.A0A232EYF0"/>
    <dbReference type="OrthoDB" id="10043757at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF3">
        <property type="entry name" value="PROTEIN SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="54888" checksum="00E02D62BA768DA2" modified="2017-10-25" version="1">MDDIRKRRYCLKKISRSSISLRKDSFSAILELVKSKPQLKKVSDRVLPPLKKEYNLHELLMESIKRPPKPLRSARNPKTSDQNIFWLDVDIKSTNNYLKKEEMLPTSQNLRKLIPVDFDLKLDEDEEDDGDNNITIDSNVRKNIVIHKSSKCISKLLRSVDKIENTNSLDDSWKLHDGLQLTKHEYHKFCDVQLESYDLATQCPSRQVVNQCLNEMLLEDRLSLTLEEIVHIRNVLTKAELESLPVEGSVKEDVEKRRICFLCLKTRFGILGPWGQRCRLCDRTICVKCYSKMKIPTDHFSQVPVLLLSPALLLSPSSMQSDSDVMKNSWSKCNRAFGSAPSSPAAKRQNPEIPNDILLKPSNETKFTKQSETSNKTFKNILYQTTAARFDYEKRSFLEASESPIKFSIARTLRAQYRNNPDQELKIDRLRGILMVVCHDCRLMVAQIIKSSRSTRTNIRNNVISRLTLNLSPAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZM8</accession>
    <name>A0A232EZM8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_012733</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001554">
        <property type="protein sequence ID" value="OXU23618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZM8"/>
    <dbReference type="STRING" id="543379.A0A232EZM8"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF21">
        <property type="entry name" value="GH07782P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="94"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU23618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="362" mass="42256" checksum="C1728079887E22B7" modified="2017-10-25" version="1">MPPNEQIHEHVLPEAVEDPLKTLDIPGFNDYYEEHKDSEFNMSAEEYNEKVINKPFLQRTDIKWGNLYFMVVLHAIALYGFLTYPYFEKKMTFVWGWFLAIVANFGVAGGVHRLWSHRAFKAKVPLKIIFILSYLTSGQYSAIWWARDHRIHHKFSETDADPVNAARGFWFSHVGWLCMKRHPEVLKKAKQLDLSDILNDPVIKFEEKHFQVLRLIFAFIIPTLVPVYFWNESWYWAILSQCFMRYAYSLNCTWGINSFAHMFGNHPYDKHIEPAENFIMTLATGGEGWHNYHHVFPADYKASELGFNYITNVNLTTCLIDLAAKIGWAYDLKEPSEKLLKAVIKNRGDGSHPISHETVKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZP7</accession>
    <name>A0A232EZP7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001464">
        <property type="protein sequence ID" value="OXU23881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZP7"/>
    <dbReference type="STRING" id="543379.A0A232EZP7"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000075">
        <property type="entry name" value="Transgelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="179" mass="19801" checksum="05BE89B8401F0261" modified="2017-10-25" version="1">MTDSFPVLQINSKYSEELAQESLEWIKAITGENINTSGDMENFYETLRDGTLLCRLANCIQENSVKKINKSAMAFKCMENIGAFLDAARAFGVPAQEVFQTVDLWEKQNLNSVVICLQSLGRKAGNYGKPSIGPKEADKNVRHFTEEQLKAGQGVISLQYGSNKGANQSGINFGNTRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZW1</accession>
    <name>A0A232EZW1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_013958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001492">
        <property type="protein sequence ID" value="OXU23797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZW1"/>
    <dbReference type="STRING" id="543379.A0A232EZW1"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU23797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="232" mass="25799" checksum="13B59FCE61A8FA33" modified="2017-10-25" version="1">MSSTSIQVQPWGTVAGKEVKKFTIKNSKNQEVDIISYGATITAIRTPNKVGQIDDVVCGFDNIEGYLSSINPYFGATVGRVANRIAGGRFTIDNVQYQVSKNIGNDTLHGGFKGWNFKVWEATIEKDSVVMSLLSQDGDEGFPGAVLASITFKLTDDGKLQIEIQSTTTKATPVNLTNHSYFNLAGHVIILFAHLILFIQSMKNQTMYIKHLFIYKTFFCYKFSINLEMIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0A7</accession>
    <name>A0A232F0A7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exocyst complex component Sec10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_004465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001403">
        <property type="protein sequence ID" value="OXU24091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0A7"/>
    <dbReference type="STRING" id="543379.A0A232F0A7"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="9">
        <location>
            <begin position="44"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="8">
        <location>
            <begin position="162"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="717" mass="82149" checksum="791B4425F1107148" modified="2017-10-25" version="1">MMQQYMKELEQEPFDPEEFVERLAWRTVNDTIKDGITGVFDPVLVHETFLQAIKDLKVLEERQQKKCDKLETLLNEEEAKHAVEILDLQERNRKSIDTFHQLDERINFVATKVLHLGDQLESVNTPRSRAVEAQKLMRHFSEFLTPGPLTDPIFTDKASLDEAADVIQKLHVIAQELPLEKFDNAKKKIAAKYDEIERNLIEEFVRAQSAEDAPRMKKLASVLSQFKGYSQCINAFIEQSQMSSFGGKDVFQEVLPMCTKNHKLIQQVFSNPEKVMAKFVLNIYHLRIQKYAVAKLADRTDTEKYLKNLHDLYMKTVKLSGDLKRFDMGTDDTYLPKLTRNIFQKHLDAYITVEIKALREKSATLLIQYYESKNHQKKQLASGGFQELKRDLQAVLSTRTNINIANIEDYGGETFLSEELAIALLQRSKTGLQRCSLLSQTCELPANATQILETVLQYLINEHVDYALELGLQCVPIPESRTQPEIHFFTVVRQCNVIIKLLEEQFSGDLLPLIISTPKHGDCMAKKKFALEQIESKIDTGLDRSINAVVGWVKIYLQTEQRKTDFKPETEMVDTLNTPACLTVCQYVSSMIKHIRDRLDGKSLENVLTELGVRFHRVIYEHLQQFQFNSAGAMCAICDMNEYRKCVKELGVPLVTTLFDTLHALCNLLLVKPENLKQVCSGDQLAILDRSILSTFIQLRTDYKTQKLANSLKGLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0Y6</accession>
    <name>A0A232F0Y6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001321">
        <property type="protein sequence ID" value="OXU24365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0Y6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7637" checksum="86702BD266F033BF" modified="2017-10-25" version="1">MNFVVSFLKIPPCTDAGHKSRRSRVKFNLNLIDDVEISVFTLFLIKQHKVQTKKRPPETRIQALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1I3</accession>
    <name>A0A232F1I3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001350">
        <property type="protein sequence ID" value="OXU24278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1I3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="173" mass="19546" checksum="98D0324860F809B2" modified="2017-10-25" version="1">MRPSPECAEETIESGASEKHGPDGHEERVTARTSGKSASSLPTVDRVRRRLRESTRSPLLVDRRSMIRGDCKSLPSVREWAGVLGSANAWTSQRPSRRTRGKNPAGPPPSLRGSGQPKPPRRRQRGHRRPPGAAREERAESRKREREREREREREREKDRGARVSIRCAGAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2W8</accession>
    <name>A0A232F2W8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_016880</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001113">
        <property type="protein sequence ID" value="OXU25094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F2W8"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000543">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056759">
        <property type="entry name" value="DYH2-5-8_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25007">
        <property type="entry name" value="DYH2-5-8_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2025"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2304"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2648"/>
            <end position="2796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3274"/>
            <end position="3347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3494"/>
            <end position="3542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU25094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="4689" mass="539220" checksum="3A1040C47ACCCA56" modified="2017-10-25" version="1">[encoded data, 4689 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F311</accession>
    <name>A0A232F311_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">TSAR_003694</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Alberta</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001107">
        <property type="protein sequence ID" value="OXU25111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F311"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000147">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="903"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1012"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1255"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1285"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OXU25111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1296" mass="142950" checksum="04F76BC6D1E09BF6" modified="2017-10-25" version="1" fragment="single">MATIDGRPAQYGLTLKQLRELMELRGREGVTKLNTYGGVQEVCKKLYTSPSEGLSGSAADIQHRRDTFGSNMIPPKPPKTFLTLVWEALQDVTLIILEIAALVSLGLSFYHPSDENEEGVLIEDDEAKYGWIEGLAILISVIVVVLVTAFNDYSKERQFRGLQNRIEGEHKFSVIRQGEVKQISVSDIVVGDICQIKYGDLLPADGILIQSNDLKIDESSLTGESDHVKKGEAFDPMVLSGTHVMEGSGKMLVTAVGVNSQAGIIFTLLGAAVDQQEQEIKKMKKGDEAGEIGNSHAVSKQHSVDGENHHGGGTSKPEHEGKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILVIQFCVTTFYIQGKIWKNTYAGELVRHFIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVNSYICEKLSKTVPNFSDIPSHVGQLLIQAVSINSAYTSRIMPSQDPTELAMQVGNKTECALLGFVIALGKSYQTVRDDNPEETFTRVYTFNSVRKSMSTVIPRQGGGYRLFTKGASEIIMKKCAFIYGRDGNLEKFTRDMQDRLVKNVIEPMACDGLRTISIAYRDFVPGKADINQVHIDNEPNWEDEENIVANLTCLGIVGIEDPVRPEVPDAIKKCQKAGITVRMVTGDNVNTARSIALKCGILKPSEDFLILEGKEFNKRIRDSHGEVQQHLLDKVWPKLRVLARSSPTDKYTLVKGIIDSKASANREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEMPTPDLLLRKPYGRTKPLISRTMMKNILGQAVYQLTVIFMLLFVGDKMLDIPSGRGVAAAGGGPTQHFTIIFNTFVMMTLFNEFNARKIHGQRNVFQGIFTNPIFYSIWIGTCLSQVFIIQYGKMAFSTKALTLEQWMWCLFFGFGTLLWGQLVTTIPTRKIPKILSWGRGQPDDIGAINLGDEKFDPDSDKKPRAGQILWIRGLTRLQTQTSNRTLVQNVSVTGRSPSQDYYMLRVIRAFRSTLEDLEERRSVHSLHSLHSMRSSRSHTGPRPLSDFTFIDEDPATKAARVIGGELQERLIPVPYSKSSTDQAIRVVNAFRQGLDSRYGEHSNTTNLAEVLRKQSSLNKRLSQTSSIDYADNLPDELAIPEIDVERLSSHSHTETAPKPHQQQQQQQQLPRYARWEKAAAAAAAAPGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4Q2</accession>
    <name>A0A232F4Q2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000949">
        <property type="protein sequence ID" value="OXU25774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4Q2"/>
    <dbReference type="OrthoDB" id="7688248at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012692042" description="MD-2-related lipid-recognition domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19873" checksum="246B989EB2ED0437" modified="2017-10-25" version="1">MSASFYLVCAVAIFPLASLEGHINVKFEDVNVDYVNDEYIDEDTFDLSVNYINETYNTLRCKVRVVKKFPDDLRISLKVYAYALNDFRIPMGISVNISICDVRTAPILVMPFISAIAGDPDKCGPDEGEYGNEDFYPVDPKMLPSVFPRNQYRLNIVIDSPSLTMLKVQFYVQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5A7</accession>
    <name>A0A232F5A7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000900">
        <property type="protein sequence ID" value="OXU26016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5A7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="166" mass="17778" checksum="62FABEC011D1D6C7" modified="2017-10-25" version="1">MSRVFALKLEEIIIFYAHSINIAFYRFHKFVAPAKGRLIATAGQLEKVEGSPAFLEDLIAGQRSANAAAAAAAFMNNYAAAAAAADRSNRMVSHVIPVSGVSSSFSSPMNIHNDLYHHYELQQGNGSLGSSGLGSVQDPVHSLKIKQEPFQLTPTSSLPPMHQGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5C2</accession>
    <name>A0A232F5C2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spondin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000972">
        <property type="protein sequence ID" value="OXU25663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5C2"/>
    <dbReference type="OrthoDB" id="7624900at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011968979" description="Spondin domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU25663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14686" checksum="344577E914D7EFB8" modified="2017-10-25" version="1">MFFSLVIACIALSIVSCEVATLDYSNITPWSVMYAVHPVYNSEPWVDVWKNERSVDISDNTINFEANDNQRSALSSMHKDVLDNNGSQQNSHSKIKDNQHSNSHQQSQTHLWPVNYKNWPKNSNKANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F690</accession>
    <name>A0A232F690_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000901">
        <property type="protein sequence ID" value="OXU26010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F690"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="60" mass="7196" checksum="BE4319B39B9B2595" modified="2017-10-25" version="1">MDVQKVEEVYDQHLRINKTLQIHSGLWPYRPIKEKLIRRTIVFIMMAIFILPHLPIVQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6X6</accession>
    <name>A0A232F6X6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate aminotransferase</fullName>
            <ecNumber evidence="13">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_013688</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70223"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:70225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70295"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="ChEBI" id="CHEBI:140699"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:70297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:21825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17441"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="EC" id="2.6.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01000855">
        <property type="protein sequence ID" value="OXU26188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6X6"/>
    <dbReference type="SMR" id="A0A232F6X6"/>
    <dbReference type="STRING" id="543379.A0A232F6X6"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120554">
        <property type="term" value="F:2-aminobutanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047801">
        <property type="term" value="F:L-cysteine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000044">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="14">
        <location>
            <begin position="30"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU26188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="406" mass="45861" checksum="5E89A5C56F5E87D3" modified="2017-10-25" version="1">MNTVFTGIELGPPIEVFALSKAFTDDPHTPKVNLTIGAYRTNEGKPWVLPVVRKVESALAADETLNHEYLPVLGLDSFSQAATAMVLGKDSPAISEGRVIGVQTLSGTGALRVAAEFLARILHFDTFYYSKPTWENHRLVFLNGGFKKNCEYRYWDPNTRGINLDGMLEDLKNAPENSVIILHSCAHNPTGCDPTHEQWKKIADVIEEKRLFPLFDSAYQGFASGDLDYDAYAVRLFVSRGIEFICTQSFAKNFGLYNERVGNFVLVANNTKLIPEMKSQLTLIVRGMYSNPPNHGARVVSTVLNNPELYEQWKEHIRTMSGRIKEMRKGLYERLQKLKTPGTWEHVINQIGMFSYTGLSEKQVEYLIKNYHIYLLRSGRINMCGINEKNLDYVAEAIHNAVTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F878</accession>
    <name>A0A232F878_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000756">
        <property type="protein sequence ID" value="OXU26653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F878"/>
    <dbReference type="OrthoDB" id="6428710at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="920"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1120" mass="123267" checksum="633CFC691D31B2F6" modified="2017-10-25" version="1">MASGFPSAHQRKLGPAPIASFEDLSDEVENQGGAEPVTRMPGIVEVTTPVTPASSLKTPSTPRIDISRASSSSQHEDSNSRESTPEKELLAGIAPPEGCKLQLGYKEDAQDLRSSTEELDLQDPIHEQDLKREAKRARKRAKELHDGTQSEHGVSIKVHGERERKDSNCSEIILLNISGRTSRLSSVGSQGSGVSGGALSVVSATSSRSPSPHKCLLETSFCGSVSTLANTLIEPSKPENDDLAKILLQREEDSTRAMIPESVRVPIVGGNLKPDPLDLPIRRRGREERKEIFRREVEITKKVLKRVNIEVPIIKLPQDPDDESSKSSSDLQKPASLDLQNDRRKRSPSTASTSSRAAAAERSVLDTPKLQRHQKIRDLEGSRTPSPSSVSRKSSFASIFKVRTDAASIQSQDSPTTSSRRTSLASRLKDTAESLRSRSKSRERPSSGEKSPGGSSTRRPDSRSRTSGGGGVFSSTLSLFKKRERKKSGSSIGTPDTLDGSHGNLDSIGCVEFTFNQQHTPSRPSSRKEDVIFISLYGDNDEFRNKPEKEDEPEETALPSESVAIPLESPTKHLDDYDASSPQQTSANIVCTDVTIEHHRKSRRSERRSRDGARISSSSGDSARLPESHSRDSQISKSESRDSKIATDDRRDVTCVSQQPISENREDARLQRMSTSSSKDSITKKPEMVKPKRKSKTIQRPTEAPPGLPPKVEVNGKVAKPIVPEPETPVQRDELILPQAPITKTPSVVSDLDHNSSESERDSEIDFIRNKAEKGIEELPDERKGLCYEESFEEDLPYVPTTLPMEKSVAVPILPVKQRLQEVKKTTPIERPRSTTPINPTLLDEFIMHTSTHDDHHDRHRRSADKMKISLPREDSFKLKSPHRPTTGHTFSEFAGRVGVPRGLSLTKSPSPPPLPPRAPTTVLTTRTTQSTQQQQQQQQQQQQQQQQQQQQQQRPANWINFEEIPEKRKAPKRIQTIPRLEDEAKLAQPGAGNVGQYSYVQPEECRCECHEESRRASLPSPRQSSTSCQPGGQTSGANGVCNGENCATNGGGQSANADRTSIVSDNSSLDCSLSADYTPGHQRSGSNGGARPFAMDLDVSSNRSSIISQEETEDEHHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8C6</accession>
    <name>A0A232F8C6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01000777">
        <property type="protein sequence ID" value="OXU26557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8C6"/>
    <dbReference type="STRING" id="543379.A0A232F8C6"/>
    <dbReference type="OrthoDB" id="115198at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU26557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="348" mass="40821" checksum="868B7AD96FF4C31A" modified="2017-10-25" version="1">MLDKKHFTTFVLFGAGFFTVLLISGCLLVWFVNNYSNIHVNLSSNVVSSRYFLMLSNNDSKNTQSYIFNKLTIDDETTLIDFKKFKFIINRSICNETNPFLVMLIHSAPSNFKKRHVIRETWGRSLSSIATLFLIGFSEKYQIQLEEENTEYQDIIQGNFFDSYRNITYKHVMALKWVTYYCPHARYMLKLDDDVFVHVQALVEFLRNRLLSTNSKRLILCDTISSSMVKRSWRSKWRVSPKDYADIKYPRYCAGWAILYSSDVVFLLYKEAQKQPYFWIDDVHITGTLAKNINLTQTSLHSMILSENMMKLLLQNSNIKKKFFLGPPNLMENEIRSLNNALAINKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8W7</accession>
    <name>A0A232F8W7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_013570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000636">
        <property type="protein sequence ID" value="OXU27266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8W7"/>
    <dbReference type="STRING" id="543379.A0A232F8W7"/>
    <dbReference type="OrthoDB" id="10071127at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="680"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="720"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="755"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU27266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113699" checksum="20243E141BA64DA5" modified="2017-10-25" version="1">MDILQKESSISHPEAEALLEETRFELDSDWDDYNQLNRALRYGQKELVKQLLHNGARVNKEPAVFNMYTPLHLAVNLGDADIVKLLLHKGAAINIKNNNRETPLIMAAKMRKDVITDILLSVDGQQNCSNRENLSHMHIACMRNRVDVVKKFIQQGARINHCVSGHSILWSGYTPLHFAVQFQCFETVEFLINSGADITSADTNKLTPLHFADILRNERILDLILSVHKYEITNPVNTEGLSHFHIACTRNNPEVVESFIKQGIDINIKVLESSLNWTGYRPINFAIDYECTEVVQLLLMHNANINLCDIVRNPIQYAYKTANKKIIDSLLSKSVIKKENAKRIKKNLSDLHTVCIQRNLNEMEMEIEEGNLSRGPVNLNLPIWAGCTPLHLAIKRRCASKAELLLKHGADITVKDSRGKTPLHLAFETKQMNIVDLILTAHLGVSANPTDNNGLSHFHISCMRNKLRVIKNFLLSGQVDVNSSVNQDSVFWPSYTGLHFAAEFELKRVIELLMNKGADVTAKNGIGLTPLDIAIKCTDSSKCWRDEVEQAFGIIDSILGHAARAKVDNFDDRGFSRLHVASINNDTLAVEQFLYTHPESVNQSVTWDKSDWLGYTPLHFAMHFGSIEVANLLLSKGACISLKNAEGNTPLHTAFGLRYHLREVENPALLYIPENPIGDEGYSHFHVACQIGDLDAVKYFLDLGVDVNMPTKFTGVYEYTGQTALHLSVSNNTVNEEVLWLLLSRGADVNSRDAEHNTPLHCTKHNVSTRPAEILLAHGAEINARNLYEETPLYLTCYDSEFSDPQVTPAKIQCLLDNGADIDLENDDGERPLTVIDSWPEHILDKPSCMAVILRHIKKLQLIGRRFSIRNFQDYYRLLTKCHANGSYREFDFTKQCREELLEMAGISVDSYTTLKDVLNKRLNDMALHSRNNDFRGIIEAPDFDRCFPIYGFLIKLQFKRGLERRPLLEEAKAAFSLAYPLPDACLERIFESLSNEDLRNVIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9J5</accession>
    <name>A0A232F9J5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_009146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000685">
        <property type="protein sequence ID" value="OXU26987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9J5"/>
    <dbReference type="STRING" id="543379.A0A232F9J5"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000006">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="353" mass="39057" checksum="051C8D8B67868D5A" modified="2017-10-25" version="1">MVESKETEAMEVDAEPSTSGTAEIAKKAVKISNVPWIEKYRPQVFTDIVGNEDTVERLSIFAQHGNAPNLIIAGPPGVGKTTTILCFARILLGPSFKDAVLELNASNERGIDVVRNKIKMFAQKKVNLAPGKHKIIILDEADSMTDGAQQALRRTMEIYSSTTRFALACNNSEKIIEPIQSRCAMIRYGKLSDAQVLAKVIDVCQKENVSYTDDGLEAIVFTAQGDMRQALNNLQSTVNGFNHVNGKNVFKVCDEPHPLLVKNMLEICTQGEISKGYEILKHLWHMGYSPEDLISTIFRVAKNLTIDEYLKLEFIKEIGLTHMGIVNGVSSLLQLNSLIARLCRVSLSYKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9K6</accession>
    <name>A0A232F9K6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose mutarotase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000682">
        <property type="protein sequence ID" value="OXU26997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9K6"/>
    <dbReference type="STRING" id="543379.A0A232F9K6"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU26997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="945" mass="108516" checksum="5360D34BA2710F76" modified="2017-10-25" version="1">MAAKRSSSASLDSAHWKKAKFENFDELRHRLIANKQFGKENVDLLNYQDENRYPLKDSKFPRTSKRYPFNNRQANKRGNRNRHLASPIQVWEHDVSGRTKNFGNDLYNREDHPDTRQNFWHQSFSRDESSFHPLYRELDAARNRLVSWDDYRIWSNELTRFHYGEPFYPILDFYAVMNTLSRYNHRRMFNEPTNFNFNHMQTVDAIHQTTFEQSNASSQVMPLGYRTSPYGSAHQFEPVKSSPAVAAPVQASNLDPMELFEKLVEYGIVPKPNTEEKKPEEEIRNDLTKKMFDTFFQPGTEQYLYLLRCTENPAALIELHSGKQCGECGVRFPIDREETDSYKDHLDWHFRQNRKRKYCWARNGTLDSRLWYSRKNDWIQLGKIEDFEKIRGMMLMMDAKKQEPSVPIMSFDDDAICNLCKESFEQFFNDADDGWHVRPAVAYKGQNYHPRCIEDYKRELERPASTPCISIKEENIEGICEKNEIEDTTDEKNGTAEEKESVTLSEAEKRFIAGTASSTHIVMKSSIDGNAMFESAAIPSIPVPPAKIQMNCATNISTPSNKTDEWNKENKMPAESPLEVEPMKLLLVPASVKPSLQGKKLRKLPTVEKGVELTGLCSVIISLKTVGYLKNRYIGRIVDQISNPQGTIGDPSSSKISGCSFDTSNWDSYILGERVVRDISVVIVMTHVSRGSSFGDLLTQVTYSWTDEQKLHVEISAVTTKPRCVDIGLCSVFNLAGHGMGPEELRKHMVTVNADRWTPICIKSRLPTGCIEDVQKTIYDLQCPTWLSSKRLRKVPGGGFNHNFCINSPSDRWCYRFHARLQHPESGRFLEVYSNHPAMRVYTANDLPDLEKVWPPDLDDEGMNANLIRESRDKIIGKDGLLYKRHGGVALIPQGYPCALNHANFPLNILHPGKVYVHKITYDFGDLNQKDIVRLNEPVSMSIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9K9</accession>
    <name>A0A232F9K9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nephrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_002284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000588">
        <property type="protein sequence ID" value="OXU27526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9K9"/>
    <dbReference type="STRING" id="543379.A0A232F9K9"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000405">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF164">
        <property type="entry name" value="MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="934"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="149"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="243"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="342"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="439"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="540"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="633"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="732"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="825"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1158"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1114"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1203" mass="132265" checksum="28AFC3CACA372A57" modified="2017-10-25" version="1" fragment="single">MGINGKRDDYDEAFLCCLHTPPQSVEIISHSRDSKIEIEQNKSLKLECIVRMAKPAATIVWYRGNVEIKGGDIHITSVPIADEKDVLKPPDHKDGKLEKYDTQGSITITSTPDDDEMVYTCEAKHPAIHIERPMRASATLSVFYKPGPPYIEGYVEGETLRRGQQVELTCKSRGGNPPAQVVWYRNGEVVHSVYTTEGHVSKNVHAFIAQASDDKARFECKVSNVMSVTPMTAHVDLSVLFAPTGVELTGPAEARAEERVTITCTTDISNPVSEIKWVVDNHRINSTSKVIPAAQGGFITTSNITFHINKVAQRAVVVCHAQNIKLSETIVGTHTINVIYPPSRLEISGYDPRTHIVAGTVLKLSCTAISGNPPATITWFKNDIQVTSTTRPRDHAVTSEMALLVNATDNKANIRCEANNSATQVPLIQSVNLNVYFLPETVRISTEPAEFRAGKTGKLICESKSSNPAAEMSWWKAGSPVTGTTNSTKNGLYGGYISSVELELELNEDMNGEEYTCQAKNPEIDRSVHDSTSLDILYKPLFETLEPNQLVGMEGEPFVISVEARANPKPITYTWTRDGLPLSSGAAGTRILARGSTLNITRLDRNDAGTYICEAMNDEGTTFYQLNLTVQYPAAIVRTSTSGAIYPQGVEAKLFCEVEGSPMGGEYITWYKESTNVGELGDRYSTYYSNKTSFLRIKHPNQRDVGEYRCNINNGISNVTSEPILFITNFKPEMANSPLTKKAAVNNGANAQLYCKAKGSPLPHFTWVFNGKTILPNLSELYSQSVLTVYHVGQSDYGKYECQAHNSVGHASESIALDVTSPPDEPSDLEAVNVTHDSVTLVWKRGFDGGLPTSHQIRWREARDDEANYRYLDVSPGNYRAVVEHLALGTYYVFSIRAKNSKGESPFLPDLLKVQTLREAPPNELIVSEINSSYIIVIIIAVSACACLLIATPIVYTAFVSKKKAQRSGPDAAENLTPDVLKERGESPMKYIYTIAATSIVFFIINVFIMLWYIVRKKNKDRINKSQTADMYAPSTVNGDTMTGELSSVSDEKSDVNFDANDYVDEGRKTAASTYLIDPTLPDYGKSGLEMQVHQQGTLNRRSNHLPSMMNMDSPPQRTTASGTLSASKSSYIGNPSPAPPSDVNFYSVEVESGRFMGYESNPSPAPASTILEGPGPGAYYPSLSPASGHHHHQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9R6</accession>
    <name>A0A232F9R6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000646">
        <property type="protein sequence ID" value="OXU27210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9R6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="200" mass="23341" checksum="5400F9B278F1DAA8" modified="2017-10-25" version="1" fragment="single">MRAPRQRDLFRFNSTISNLTVKLSELVMVTSNFGGIFIIIINLLILNAQQETTEVSTFIKTHHGLINNTCVSIIESITTKCLQEHKFIRAMGISNCNHREDIYQDTSKHQEYTLIITYDGAKCDSNKKENFMLIVNDKICKVVHYEESYKFYKKWVITPLSWSTWSVVALFILAVCYTIYSKLLRDRIIKICRMIVVRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9W1</accession>
    <name>A0A232F9W1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_002813</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="NNAY01000637">
        <property type="protein sequence ID" value="OXU27260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9W1"/>
    <dbReference type="STRING" id="543379.A0A232F9W1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="31"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="241"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU27260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="826" mass="95408" checksum="2AF588E84C8D0EC4" modified="2017-10-25" version="1">MSRKTIEDDILSNLNKFFGYKSLRPGQLTIVTQILQKNDVLICKEKGYGKSLCFQLAGLIQDGVTIIISPLLSSAEEECDKLAAFTRIKCAYLHTDNHQDQEQDLRNVLIKKNKVLEDLRNPRSSELKFLYVTIDYILNSSKLKHILIELYKENLLNAVVVDEVHCVTQWIYSFKSDYLTFGFLRDLFFNVPFLFCSGPITKQTLALIQTILHLRNPYIFNDPSVRDNLSYKVMYKGNNFPTEKLIDYVKNAYTGKTGFMYCQNKESCLALSKKLRENGVENFYYHSEISDKDKAALHAMVISGIVVVCVSGADVDISLQKVDYVVHTVIPNCLEVYFQEAGKAGKNTEYGDCIMFYSMDDCDLDLRSSVNYYMESMKLANAEKKEQLGYQLKDYRRKINEVVVYAENTSICRQVFLLKYFNDESVEIPCGICDVCIVMKDGFVIDMSHVLRKILMCAWSINRYQKSMAECDLFFTATVPNIIAALLGTVKMRHCDLWLVKEWFYGSFASWDAQVLHRFLYILISHRYLAVNHVFNENFEAFENLIITPEGQEFVKSNNELTLTFSLKDTSFTKWLNIDWIADQYKKDLDGVVLYHALHSNLQRVAEWHGPYVTHLFHTVPGTWDEFKEIKMNYMKNEKNNFDEDLFTVRQWSLNVRIKILEKAQFLTTPALTIGLNITNSMVINPPPPSVPHLILPQYDGIRAEPLSKQLTDAKNPQSREFPSSSIDLSKGNISESRSFSGMSEISAVIKLHNYSKMSKNNNYSRFDSKKPKGIVVGVKRKPYDEKPESSKITDYQKLTYESGWDRTDNDYKSFVRKKRINPVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB88</accession>
    <name>A0A232FB88_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000510">
        <property type="protein sequence ID" value="OXU27925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FB88"/>
    <dbReference type="STRING" id="543379.A0A232FB88"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="213"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="375" mass="42803" checksum="CF68FAC604D823CD" modified="2017-10-25" version="1">MMDLEQSNDASFTGSIEVVKDELIWIIRSVNPDKIRSVRGIVSQTVFVGCNGLSSTLHLQPNSTSEFLSLTVYLNPTNESLPSKFWAYIKCQLLYDKQMLASSTAVGTFSRKQNYYVFQNFVRPSDLDNRDRVVVCCFINVLDRRVNQIEYEASSPGLYSRENDTGACRAKNEFKKEKVLVPESTWTFCTRPVCGKNSSKRYSYLEIFGAESSDVTLVSQGEEFPAHRNILTSASVVFSAMFIRSAEENADNRIVINDVNPDVLYQVLLFIYTRKLSRYELVPDLLIAADKYKLEILKTLCERILFNKMNPTNVCGILLLADRYHFQGLKNWALFFISAYADQVIQTPGFQALKNSNNTDLMAEVYREIDSFLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBD1</accession>
    <name>A0A232FBD1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000545">
        <property type="protein sequence ID" value="OXU27769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBD1"/>
    <dbReference type="STRING" id="543379.A0A232FBD1"/>
    <dbReference type="OrthoDB" id="7696577at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF43">
        <property type="entry name" value="ODORANT RECEPTOR 47A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="396" mass="45838" checksum="7413AC2838C58D12" modified="2017-10-25" version="1">MDIFDSRYYKTNIFYLKLLGLWPFDDFLNKRVRRILIIIAVVSLIIPQVIRLFEEWGRDIDIVIEVIGSLIYFSGCQIKYLSFLRVEAKMKYLYNKIAEHWKSLSSKDEIKTLEEYGEIGRGLTLGYIIPINIILVIYISLPLLPLLLDVIDPQNETRPKQFPYFAEYFIDDQKYYFELTIHGWIVCILSVQIYGTFDTTYTQCVQHACGLFGIVEQRLKKATKLASSNEFSTLEEKDEKVYDKFFTKLTSSFFTTCRFVNLIEDCYSFSYFFVVTLNTAVVSLAAVDTMLNLENGNTKQMVRIGALYIGFSFHLLYNMSPGQRVIDSSTNIQNAAFHCDWFNASSKTKTLIRIIMLRSLTPCQFTAGKLIVLHLESFAFVFKNSISYVTVVGSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBH7</accession>
    <name>A0A232FBH7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000462">
        <property type="protein sequence ID" value="OXU28204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBH7"/>
    <dbReference type="STRING" id="543379.A0A232FBH7"/>
    <dbReference type="OrthoDB" id="47923at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF6">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="266" mass="29946" checksum="EC13FDB535D8986B" modified="2017-10-25" version="1" fragment="single">RLIADLNKEQEAFIAGKPGEKGEAVAPWIGAPNEDALREECLALSTDRRNFVRAPPPGVDFAWDFEAVQPMAQATLALDPNLETMRFELVPKVISEENFWRNYFYRVSLLRQSHELNAMANQSTESNPSQLASSDSVDHTQAGATKSEQEEGKSAAPTTKDESEPEVQQVKEAVSKLTVQSKVRSSCCSLPAFYIHVYSAFLNCRIGSRNSMNIYVLYSFKLRTTIALTAFNVHFHQYCLSRCIKEDWERELEAELKDYEVVPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBN9</accession>
    <name>A0A232FBN9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_014997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000489">
        <property type="protein sequence ID" value="OXU28032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBN9"/>
    <dbReference type="STRING" id="543379.A0A232FBN9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF33">
        <property type="entry name" value="CROSSVEINLESS D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012036929" description="Vitellogenin domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="833" mass="96811" checksum="00BB7912B99B95AD" modified="2017-10-25" version="1">MFFWIIVLLFTILPKNEVDLYKYTAEVKAKVYEPIRFESSSKVNANLHIQQESKESDSISYIIKLQNITVSEYNGRSKDKHLRTRTTYRPKGSEIIEKPFLVVYGEDGQDDNISSVNKVYEIHVQGKSTKLMKYEGDEIETRMPYLHKSDGLVIRTKQTIIYEKSDAKQRLSRSIFDEEPLVQDVIYDKTTTYVADGARDDITQGRHDFGKGNVTEVIELLKASYDYMNSDRKIYLDILCYVGTDASAATIRDAIRFGEITDTEAFDVLSKFPQYVLEPKEDILEAMEILLHLDEKISHDVKKAGILSFASLVYRIYKDHSDATIPERLEKYLQYFNNKLQDAVKAQDNEIILVYIMAFQNIKIGNIERFLWPILRKEVKIQNDGDRIRVATAFALFGGISSNHELVHNVYFPIFSDESEYMPLRTASFLRLMYVTQLENQTRPMEMYWQYTAQKNPLIRNLLSSNILTHANFGTTCRQTIREIYEKIVKFAELKKVNFSIPSFYWMFDALENIILDGLKYFLKEDPDIQKLITEYESKNSTNSTLVIIPFYGFQATQVYYYDTNSLEDYKEQFWQQIFNTINLTTIYYSKLKESTAGTDIGVPNYFRHHEPTLFSFKVYSYAKLEDKTVNVKLNLKFNTWADSSYDLSIYNSLADTFHQVRRSTYVDTMLPISFELSYNVETKTLQISVSETTDTDEFRTKLSTYSKVYSMLYSSNSDERQPLRSKTVSKGKNARKEFQSAFESNLTSIKYNLDIYDCETGFSPDVDDQEWLDAVNNPDRNNLFGPTFEDFLVAKQKLVEDMMSARPGICGMIKEFLPINGNLSFVVKLKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCC7</accession>
    <name>A0A232FCC7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_013888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000480">
        <property type="protein sequence ID" value="OXU28089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCC7"/>
    <dbReference type="STRING" id="543379.A0A232FCC7"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19813">
        <property type="entry name" value="Bbox1_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19798">
        <property type="entry name" value="Bbox2_BRAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20482">
        <property type="entry name" value="CC_brat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14959">
        <property type="entry name" value="NHL_brat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="11">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="674"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="721"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="102863" checksum="47B72817E0BC187E" modified="2017-10-25" version="1">MASTTLAVPANVTNSVTSVTSHSGSVKSDEIDGSESYGDKSASFSSRNQVDSLEEINYNDGDASDQNHCGICSDKLSSPRVLSCLHVFCESCIDKLHNVEDTVDHKTKSIVTCPMCQQETQVTSKGAASLPCDYVLTNILDMSAIKNTAVLCTSCKAMENAVARCSDCANFLCPNCNTAHQFMRCFENHKVIAFDDLRRSDEAIPIHKPIFCDSHPMENIKFYCYTCQVPICNECLLVEHKAPEHQYERLKDAEPRHREELVNLVNESKARIGDCDQISSQLGNALSELQAQRDQAKDLILETFQSYKAILEKCRDNALNDLEKVHSERELEIMDSFHTVEKTVEKIECACQFTNRLLEHGDTTEILSLRHTVTRQLMDLLKNMPKPNISSSIEFQTDYNNFEKTIGESFGKIYTENIPSINSPTGTVNDIPVGITTQQISHTSVGCPSSMSASSPISLPASMQSSFEGDTSFVIPAAPSPNIPAPPPVPVSSIPPASMHGLTSIQEYNLQQLASLAEKVDITGDTGVVEPSSNPSPTPSFTLADLFAGDLSSTSHAINNLQALAKLGNSLVINQDLNPSAAMNGSNIVLGRGSSPVVIDPPNLATLTGNALLNGGGFQSISSSTSPILSQTTDDVGAGDSIQNMSTNGANSTTNNFNARSSSTNPKLPPMIIRSKFGQLGPNKSQFNSPHGFCLGTDEDIIVADTNNHRIQIFEKTGIFKFQFGNPGKEEGQLWYPRKVAVMRNSGKFVVCDRGNERSRMQIFTKNGHFIKKIAIRYIDIVAGLAVTSDGHIVAVDSVSPTVFVINDAGKLLWWFDCSNHMREPSDIAISGKEFFVCDFKGHCVVVFREDGQFLRRIGCESITNFPNGIDISDAGDVLIGDSHGNRFHIAVFSRDGSLISEFECPHVKVSRCCGLKITSEGYIVTLAKNNHHVLVLNTLYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCU8</accession>
    <name>A0A232FCU8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_016742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000430">
        <property type="protein sequence ID" value="OXU28452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCU8"/>
    <dbReference type="STRING" id="543379.A0A232FCU8"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012918047" description="UDP-glycosyltransferases domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54626" checksum="6B764B7D508D62C2" modified="2017-10-25" version="1">MACLICLVLSAVLIHSAAASSLASPPQSAVVVAFEDVYELSLLANTISDLGIETTLVIPANVSDYYEHLVGVDLMTVNASLKADDSDDLKAVKLCESFISDSSIAKHVKSLQPTFIIFPGVRHDACLLPWTASVSSIPVIYARGHNQELYVFVKTGMALPVHETGLLQSFIENLNLKFYMYSIESNYVSATHKMIQKKLPNVDNSLANLYSNVQLVLWGADPILRMNSALLTQLVAEIGCHHCRGPQPLPADLQKELVEFRAGSVVVLLDKDYDVLIRAVAQKLPNDRQGLAVIWKNKHAKMHNKPNNLFIHKDVDRQDLIGYSRTRVILAHCTDSEFLESAFHGSPMICFPRNVDELRNARRASELGFAYVEKIDAMSDAVSETIKEIHESTQYRENARVVSQAIRDRSNHAMDRILYWLGYTARHNGEGKNLLVPKKVSTYNEILQSVAGFLVGVIFTTLLTVVFFISQNIFESQKKKEKKRYHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD03</accession>
    <name>A0A232FD03_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000444">
        <property type="protein sequence ID" value="OXU28338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD03"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="117" mass="13775" checksum="2A331BF1F1B26AE7" modified="2017-10-25" version="1">MKWLRSWRLEAWMTFAYSRKDCNGRFPSCCRLMHGSSNQTITFLEIRHFAANRKYRTSMLEPFTTNVVAVFYRCNSVKSPNKVTSHVSERLTSIVSCKKDGTCDWKSLVYEFEEQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FD24</accession>
    <name>A0A232FD24_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000391">
        <property type="protein sequence ID" value="OXU28704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FD24"/>
    <dbReference type="STRING" id="543379.A0A232FD24"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="1">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="98" mass="11061" checksum="B56895CACA798ECB" modified="2017-10-25" version="1">MVKSLLVGTKTVLDMAKTLRNLVAFVHLSTAFCHVDQEELCEHVYESPYNPHDVIKLVNWLDEKSLKLITSKGAVVPGWQQNNAGIRLIVHYTTRGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDE4</accession>
    <name>A0A232FDE4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000380">
        <property type="protein sequence ID" value="OXU28781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDE4"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="103" mass="12009" checksum="4F9B2CDE7CB49E2B" modified="2017-10-25" version="1">MKNMSSHEKPKKLKLQHESNDNSLITKTRTPCILIFDSAPGIIPINVGNMIVEYLYWEYKLKKNSTIKLSDFDVKCVYPEHLNNTMLMIAVFTLCHMLEVFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDJ2</accession>
    <name>A0A232FDJ2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_009149</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000365">
        <property type="protein sequence ID" value="OXU28856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDJ2"/>
    <dbReference type="STRING" id="543379.A0A232FDJ2"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="452"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="544"/>
            <end position="550"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU28856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="759" mass="86453" checksum="CCE1863BA20C0286" modified="2017-10-25" version="1">MGRKAKFDEKVEKKGPNRKGKKRQEPVFPDGLLKKEPGKLSHRQAQRAKKRLLKKEQKKDARKAKQEDKKAKNKSFNEHSFDESDKEVVNANKKRQLKNDNNVSQPKPKKLKKAEKEPKLQLFDEDDEPNLSKVDKKKKLKSKANGQEFKVVKVAPESKQKQKVNSKKQNLHTDESKIATKKNSSKNVSKNVNKKTAQVKNIMQKSKANQKTKRAKTNLELIMNPDTSDEDEDDSEEEGGLEGFEIGESNSEDDLEETDDYLVQQNDDEDDDDDEDDDEDDEDEDNGDEDEDEDEDEDAGIDNDEDSDQDSDAEAESQDSDDSDDGDDNSDEDEEDNNLLPIEKANKRLKKKQEKERKLAEAEMNESISHQQIFNFPTEEELSNPTNLKDVQQRIQDVIMVLSDFKKLRQPDRSRSEYLELLKTDLCTYFSYNSFLMEKLMQMFPLSELLEFLESSEVQRPMTIRTNTLKTRRRDLAHALINRGVNLDPIGKWTNVGLVVYSSQVPMGATPEYLAGHYILQGASSFLPVMALEPKINERILDMCAAPGGKSSHIAALMKNTGVLFSNDVNKDRIKAVIGNFHRLGITNSVICSYDGRKLPSVIKGFDRVLLDAPCTGTGVVAKDPSVKTNKDEVDIQRCCTLQRELLLAAIDSVNARSESGGIIVYSTCSILPEENEWIVDYALRKRDVKVVPTGLEFGADGFTNYRQHRFHPSLKLTKRFYPHMHNMDGFYVAKLKKFSNIIPKQDKTVDEDEEEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF52</accession>
    <name>A0A232FF52_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_006552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000332">
        <property type="protein sequence ID" value="OXU29150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF52"/>
    <dbReference type="STRING" id="543379.A0A232FF52"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="192"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU29150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="348" mass="37761" checksum="C93E7F25A14EF9C6" modified="2017-10-25" version="1">MPEHVELQHLVDGDLECQNAARKNDFSTPKCKSCPYLGLVLATLSSLFFSLCSVIVKGLVEVNPMELAAFRFVGVLLPAIPIVIYKGDDPFPKGRRLMLLLRSFVGTTGLMLSFYAFRHMPLADASVIVFSVPVFVAIFARIFLKEPCGLFNVITVCLTLIGVVLITRPPLIFGHTVVSLTDNHVETENADLWSAVAAFSATLFGANAYVLLRALKGLHFSVIMSNFGSFGLVQTLIVTWAIGALCLPRCGTDRLLVVALALFSFGGQILLTLALQMEQAGPVAIARSADIVFAFFWQVLFFNEIPNRYSVGGAILVTSSVLLTGLRKWAVSLPETSGVKKSLGFLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFC9</accession>
    <name>A0A232FFC9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000332">
        <property type="protein sequence ID" value="OXU29158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFC9"/>
    <dbReference type="OrthoDB" id="166212at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF41">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="113"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="541" mass="62882" checksum="996D6FF009915E67" modified="2017-10-25" version="1">MTDPMRRKSTVREALNEANLFLKQRVIVGKLRGRYLFRAAVRLVIEYKDWIGNGDSENIGDDVTVNVKLAQRKKSSEQEDLTVKDRSILLISPHKRSKDDVAYIEYLLKEIKAFKRYPEDVRESLASDCGYQFVPAGRTIIRQNHKARLLYYVVSGQLQISRNLEEPVTEEVKQIDAGMLKPGDMFGEIALLHQVPRTATVVSKTPVDLLLITRKMFNIYLRHFLLEEWDILRDALVNFNYFKGWTEETMRECCILSKIVNYKPNEVLLGDGKGMIHYVYFLLNGECRLVEHMLVETKRVGKHVKYKLYESQQKDRNPRQRIGRSKKLELPDDELSAIIMESASQDGSMGNITAKEQSSSPADYIKLISSKKPNTNIAIERVSVITVTLQDVINQWHEITDVVEMLMRQPSTTNLKNYPKNVKTVFMQICTFYRGACFGLGEQMKNRRVVSITPSRCLLIPRYWLTQHNRANIWERVKQFMNSVFPDNKQLLDKYVENKMWAKHKKEYAKNIVKCGRDIPNDTKLCDVPYSIRINENIIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFD6</accession>
    <name>A0A232FFD6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MMS22-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methyl methanesulfonate-sensitivity protein 22-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_005155</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MMS22 family. MMS22L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000347">
        <property type="protein sequence ID" value="OXU29027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFD6"/>
    <dbReference type="STRING" id="543379.A0A232FFD6"/>
    <dbReference type="OrthoDB" id="8193282at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042320">
        <property type="entry name" value="MMS22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029424">
        <property type="entry name" value="MMS22L_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029425">
        <property type="entry name" value="MMS22L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547:SF1">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14911">
        <property type="entry name" value="MMS22L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14910">
        <property type="entry name" value="MMS22L_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein MMS22-like N-terminal" evidence="11">
        <location>
            <begin position="138"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="MMS22-like C-terminal" evidence="12">
        <location>
            <begin position="772"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU29027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1138" mass="132044" checksum="78077AE8D925A124" modified="2017-10-25" version="1">MSKGTFNCSGKVNLHDWQLNSSSLFMQKDLHNVLHEKPPLNSVFKVFECELPGIDILMNLKHYVRCMESNLKKLCRFEKIPVLGKLPATNEEIDFFVIRKVVCEFLYNLRSYIKSIREDNFTIRDVGDESEKDFEDLLDTMQRFLGRLHCIPDSTFLYAPSNVGNKSNQPEYHLYHSHLDLRWLLTTIIYIKSNSWHESESNNEHLENIIFSALADLIYISMKIFVTIPNTDLHTRTPYSCSCVRELWLMLQILADSLFTKEKCKMFWEFLNSILDQLFPNEYRSTSKLQNINLPDCKNSEVFCIWLIYHLTLLYGYADDGVYSNKPSTRMTEKQISCSMAQVVKIMKIYINKGGKDGAREEVDDELCVIIPLVHVLSCEWWSPQVQIISLLWECFHRRLDQPFLLQTRGPWSTSSEKKTPMDILEQIKSRIKNTNHEINHESSFGLFLRLLGKFLEKHYSRSEAKVWNQIKGRIYSRFSQNKLQDYTESGIYNFISLFLTLAVTTDTVDVCSAMVNLLPSTIDWSDPSNSKKYCLIWKSKLAVLLLYNDCKYSFKDIAESYTETANAISCRKDEFSRSMMVWFIDVLRITLMQSEDFGRHEHAFLGGWIDRYLLESAPNKVGVLTSTLLKVFEKCNDLLSSNTMGSTLMLNSLWQHVASRVRQMVTNCDLSTDFYENPTKLAVAFTLEACRDPSTAKKYRHSAVSLFQHFTMSVIIKDIRITQLYLTAILQNEIALETLRKEIANFNTLCIQAWVKCNILNCEINSDKHFLKNYISHLPEIKSILDSERDINEFRNSNEPIIHFFMVISKKRTTLKAEQCSSFDATCRSYLHNLDKWALQLINEENKDTKLSFWIYRCIGTVIFCCSPVLYVKNQPSNMLRVLINKVALPPEQPAQPHLVHLAQRIFHMIILGIENLNVKADISLQTMIRELFERYLPLLITVEASNENAFKVADSLSKCFLEAKPNFVRSILDMLAANFVTICGSNSTHKHCYLVMLLLRNLIRAGKIYSIDVLDSIVSVSASSIFNCYMRVHDHHPHKQQTIDFLKDVSLNSYYKENLSLREKLNEIVWNALNKYVQTNSKVSFEFVSSISKINIELLKYIYPRIKQIVSECEKNKLPNAAALRYQEYQLLSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG04</accession>
    <name>A0A232FG04_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000285">
        <property type="protein sequence ID" value="OXU29493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG04"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="270" mass="30569" checksum="04F8D9B420CF7356" modified="2017-10-25" version="1">MYVTEADWRFSSFGLMKRPYTYTTTRKIPNAGHKSPKFIIKRAAREKNDKRRKFSSDETRGKKKTQKRDQPGSTHSKSAHSSYFSLRADRVLVPYFNLKAIVWVWIPADTNLHTVGGDDLAAKTTGQLDAQLGFTGAGGTQDHQDRRAKIESPTATRYINYALEQHLSSAPILVRKSSGIHSDARHRWLYIARECLAFCKIFSSSLSLTTFVLIILFSHAPTALARCLFHSSASISSSSSSSRFFLTMHKRHSFARSLHYFVFSFNAYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG11</accession>
    <name>A0A232FG11_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Craniofacial development protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Bucentaur</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_009180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000287">
        <property type="protein sequence ID" value="OXU29460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG11"/>
    <dbReference type="STRING" id="543379.A0A232FG11"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="283" mass="31516" checksum="A4A93F8BD8735607" modified="2017-10-25" version="1">MGDKDYDSSDSDDSDFVAPQDELSDDSIQSDYDSEGSEGSGHESSNDKKKKNTKTRKHKATKSVGRKTRSTRANKDDELSGNEKDDSTTTIDEKERADSLWASFLSDTATPSKLKSSNTSTSSKTPFCDTSTSANKTDVPKNSSTSYSADQSDTSNATKTEDSKFPITSVTVKDNSENTVTSANEKEDKPKDKPKLPILNRDIKRKGITSVLGSLNKKTKLSTLEKSKLDWNQFKEENNLKEEINTFNRGKNGYLEKQDFLQRADSRQFEIEKQLRAGKRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGE0</accession>
    <name>A0A232FGE0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_000429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000231">
        <property type="protein sequence ID" value="OXU29836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGE0"/>
    <dbReference type="STRING" id="543379.A0A232FGE0"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="10">
        <location>
            <begin position="713"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU29836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="848" mass="96107" checksum="B353E220B0088875" modified="2017-10-25" version="1">MASSEEDILEDLESMIYNFPPSVQAVIEKVLPSNDPLDQPDFNPVDYINALFPTEQSLSNIDDVINNMEQQVQTIDKEIRSVVRNQSNNSQDGKAALEEAQKSIRQLFVHIKDIKAKAEQSEETVKEITRDIKQLDFAKKNLTQSITTLNHLHMLVDGVETLKDLTKKKQYGEIIMPLQAIMEVMQYFNIYMDIPQIKELSDQVQQIHVELANQITTDFKEAFSGQNPKHFAQLTEGCLVLSVLDPKVKKELLTWFVSMQLQEYTHLFDENQDFAWLDKIDRRYAWIKKHLLDFESKFASIFPQDWEVSERIAVQFCHITREDLSKLMHKRTPEIDVKLLLQAIQKTTNFENLLSKRFLGVTLEDQNKQEKKQATGATAGAIAVATGDANVPGNPFETETTEKSQVEPEKPMASPFANLIGKCFESYLYIYIESLDRNLSELIEKFVADCKAHPPGAGAYEGNEGPSSVLSSCADLFVSYKKCMLQCTQLSSGSIMLSLAETFQKYLREYAVKILQNNLPKIGGASIGSSVSSITREFRDLSTSGFIQNFQSFLKEGESGSRFSKEEQARICCILTTAEYCLETTQQLEEKLRLKTDKIYADKINLSQEQDIFHGVISNCIQLLVQDLELACEPALNAMIKMQWSTIESVGDQSGYVSTIVSHLRQTVPSIRDQLASCRKYFTQLCVKFVSSFIPKLTQQIFKCKPLSTVGAEQLLLDVHMLKTALLDLPSTGCQIQRKAPATYTKVVIKGMTTAEMILKIVMSPTESPSGFAEQCRKLLPDLKIPEFQKILDMKGLRKTEQMLLVEEFKQRLSIDSSAELRSSVTQESPEHEAGRIKKLEKLIKKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGS5</accession>
    <name>A0A232FGS5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000243">
        <property type="protein sequence ID" value="OXU29763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="8671" checksum="A330814E9ED87B6D" modified="2017-10-25" version="1" fragment="single">GPGVTFSHKLSPRTDALLIKRRRKLGPAKTKXFPEDYRRDSKQCARSSISIAIHTQSCARANASRQSTLWPGSHRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGT3</accession>
    <name>A0A232FGT3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000216">
        <property type="protein sequence ID" value="OXU29961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGT3"/>
    <dbReference type="STRING" id="543379.A0A232FGT3"/>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="370" mass="41040" checksum="23AAF50EF15DEA16" modified="2017-10-25" version="1">MFKEPSSVASSGSRKGDEVELVSRFLAPLFTSDLESDKVASSKFTVSRCGITNGNANNYQGQQQQQSSFEGFFPQSVSEGAATIFSRKPSFDANLTPERYPSGSFDCVDGGKEASAATNLEYNGSSNGTPSHESRLLSYRLKDAETRFGSSSESDRRFFASNEGLNEEAESKQRNGSSRHYTRIKSGRQKQFDEDDELDADTRVYGKSPKFDDDFGNPEFRNRHGRFNEDTSAQYLGSSLEADRVVFNTLDGFMNESKSSSPPERKLSIGQIKRPLSQDEEVPWKSGRVLESPAEVVTPGDVGRMLNLGNALDGPRQAQANKYLSLVSLHLPVILRLSVNCPFQNVRIKCAEIIQMIKVKLVFIRMRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGX7</accession>
    <name>A0A232FGX7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_009071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000271">
        <property type="protein sequence ID" value="OXU29587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGX7"/>
    <dbReference type="STRING" id="543379.A0A232FGX7"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF32">
        <property type="entry name" value="APYRASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011822069" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="344"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU29587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60412" checksum="9F39B1983EF80211" modified="2017-10-25" version="1">MISPSQSIFVTLLLLFFAFVCLSLPFNKVVSDKFFELSIIHFSDFHARYVPVSPSGGLCHENEKCVGGIARVANIVQRLKQIRKNAIFLNAGDCFEGTLYYGIYRGNITAYFMNELPHDAMTIGNHDFDDEVSGLASFLKQLRAPVVATNIDRSQEAELRDLYTNSTVISKGGKNIGIIGAIFSGTDKISSTTGKVKFLNEVETINLEARKLKARGVNIILVLSHCGIDRDKIIASTCPDVDVIVGGHSHILLYNGKAPSNDIVYDKYPVVISQKGSDRKVLIVHASAFTKYMGDIRIVFDEDDEVAHWEGDPIYLDSSVQEDQTIVKELEPWSIEVDKIGKRVIGETKVFLNDSCYAGECNLANLITDAMVDTYSTNSSIALTTALHVKNSIPVGPILYEDLYMASPYNGTWDLIELQGKDLLQVLEDNVATSLDNSSFINLKLLHWSGLKVTYNLSNEKSKLVSAKITCLECKGKLEDIDVNKWYAIVVSDYLLTAAFETIAKKHRNRFVGLVRDPDNLADYIQKTMKAVDIKTEGRMIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHK8</accession>
    <name>A0A232FHK8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000218">
        <property type="protein sequence ID" value="OXU29948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHK8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257681" evidence="1">
        <location>
            <begin position="21"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="993" mass="112880" checksum="7E01BE9511E34546" modified="2017-10-25" version="1">MKTFTIVLILGMAYCQFGNASRLEDMKTCLVENGFTDSHADLERLQAIGDPEHVDRLKDVSREKMAGVIACMFQRRHGNKNLNEALQNLIGRDDKVTEEERKKMQETLKSCNANVTGDNIKLLSCLNIMAPPFDVLIAAFRDLDDSVGICFPRCNVTIGEMYKMQKNMEMKTKVKDLLKIVNEQKMVCFMTCIVDEEAKINRLSPPFLRVLTDRINKSENHDEDQKKEMLKTLSKCNAQVAEVKDKTYEMIKCVNIMYVVALKLSGTIDIEYSHKMKTFAIILILGFAWRVSNASKYVNMKTCSVENGFTDDETDLELIRAIGEPEHGYRLKDVSMEKMAGVMACLFQKQQGNGNLNNALESLVGRDDKATEQEKKKMLETLKICNTNAAGDNTKLLICLNIMAPPFDVLIATFRDFDESVAVCFPKCEITIGEMYKMEENKSKVKGLLEIINEQKLACFMACIVEEEDKNRKSPHFLKALTDLINKSENHDDNQKKEMLETIDKCNAQVAEVKDKTYQIIKCVDMFKPPFTDARETDFEDLIFNDLMSMCLIENGFTNSTADMERMYAIGDPEQADKLKDVPKERIVDVIVYDTVTVGQIRQMEHTMSDCYKEAGGKINNAELLKCVDITEPPFDHLFAAIRDVRQALQWCFVRCGVLISEMYTMEKNRDLPFKEYIKYIPHEKISCLMACKAEQAAVNNSNQTLQKGLADLIKRSKNVDEIEKAEMLKSLKKCSKKVYGYEDEHYELYTTSFRVKDSETCLMENGFTDTDLGNIESIGEPDLIDTIKNIPTEKIAAVVACVYQKQYADKNLHNTLKVLIDRDDKVSEDEAKKMKETLATCNTNAAGDNAKLLSCVNLVAPPFDTLIAVIRDLPESQDPCFLKCDMKIGEMYKAEQNRNKMKDLVKHVPEEKLSCIFGCKVDEFDKTKPGGKTISQRIAEKVNTSKVHDENQKKEMLETLKRCTDTVAGQPNENTLLGKCLDLFKPPFVDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHL2</accession>
    <name>A0A232FHL2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hemolymph juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000182">
        <property type="protein sequence ID" value="OXU30234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHL2"/>
    <dbReference type="STRING" id="543379.A0A232FHL2"/>
    <dbReference type="OrthoDB" id="8185598at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF14">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012669427" description="Hemolymph juvenile hormone binding protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27201" checksum="55CDB0B6FE27D216" modified="2017-10-25" version="1">MAHGTTLALVLCATLACGFAIELPDFIHVCKRNDPQIETCIKKSVEDLRPKLMTGVPEYNIPSLEPLLLKELVAAEGAGGLKITAKDVHAYGASDFVVQKLRVDVSQLRFALDILLPHLYIEGQYEIDGRVLLLPIRGNGPMTGNFTDATGSVKIQAGLFKDDQGNDHLKLSEFRMRISIRKGSLKLDNLFGGDPTLGNVVNNAINTNFDAFIKELQPLIEKALSSAFTDIGNSIVRPFTYEQLFPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIL4</accession>
    <name>A0A232FIL4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000166">
        <property type="protein sequence ID" value="OXU30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FIL4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="138" mass="15895" checksum="BA812DDDD024A546" modified="2017-10-25" version="1">MPIQKDKEVLKNNCPHTVVGTPGHISALIKGKKLSLQHLKFFILDEDVTDRRNFPTIGIYKGMTQEERFTKYQSFKDFQQRILVAINLFGRGLDIERVNIVFNYDMPENSDTYLHRVARAGRFGTKGXSLERACHTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIM7</accession>
    <name>A0A232FIM7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_014915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000172">
        <property type="protein sequence ID" value="OXU30318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIM7"/>
    <dbReference type="STRING" id="543379.A0A232FIM7"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012014276" description="Phenoloxidase-activating factor 2" evidence="8">
        <location>
            <begin position="24"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="264"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU30318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="498" mass="53156" checksum="41CB7DE9BE32E179" modified="2017-10-25" version="1">MGRFAILGIASFLLLVLLGTSYAENEQLAEDDSVVVKALPDPELTGLTASRRGSRQLFSQRGPCLTSKGAVGKCTTFKECYPYFKIPDLGALDGWVLGIYDTCSYTQSDGRLGFGICCADVPVLPPDNEAPPVDDPAAGPIIEEPDNEPQDDMKAGRLPGEGSWPPPLPTHPPHHTIPPLPTHPPGHPGAATGAPTPKPPQVPGFPTTQRPLQTTWPTKRPGGFPSGPNPVPTPAPVAPAATSTPPSFNAACGAKNGPQDDKRIVGGHPTVQGEWPWIAGLFNAGRHICGGSLIDEIHILTAAHCVAQMNSWDVARLTVRLGDYDIKTPHEVRHIEKRVKRVVRHRGFDMRTLYNDVAILTLNEPVEFSETIRPVCLPSGANLYTGKQAVVIGWGSLREGGPAPGKLQQVSIKIWSNAICKQKYGGAAPGGIVDSFLCAGEAARDSCSGDSGGPLMVNDGRWTQVGIVSWGIGCGKGQYPGVYTRVTHFLPWIYKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJI9</accession>
    <name>A0A232FJI9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Probable arginine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_012649</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000114">
        <property type="protein sequence ID" value="OXU30845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FJI9"/>
    <dbReference type="OrthoDB" id="2306477at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12304">
        <property type="entry name" value="RRM_Set1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000002">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000084">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000064">
        <property type="entry name" value="Probable arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="181"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1629"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="281"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="640"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="728"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1037"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1751"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2185"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1051"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU30845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2381" mass="264867" checksum="F41273C66C83FFF1" modified="2017-10-25" version="1">MNGMERHGHGHGHSHSHHHRHHHHHHHPSHHHSDSGTGSSSHHHHSSHSNSSQNVSHNSNSVAHQQHHHQPPQQQVVSKHNHGQPPPPQKDTSSGGSTASGPVALQKPRNYKLLVDPFLKKGATKVYRYDGLVPGDPTYPAVQVRDPRSQLTRIWTRLDKMDLPVPRFKIDANYCGDPPPLEVTFCHLNDNIDRTFLTDMVQKFGPTEELTIYYHPVTNKHLGIARVVFETTKASKACVEKLNNTSVMGKVLRVFLDPFGDECRKLYEDLTVEKKVEKKVEKKVKEEPQTPAAVIPPTTSIKNEVEQNKRGQTPLVSAEKTSTTATDERDSRHNKKSSHEKSRDSYVENSRFTSKMTPNFRGDYPTPGGTSTSSNELGFSTPSELNYPSNFSQNSTPASNYDYFYGNYHHHHHHPPPHHHTAANPAAANFIGGLPPPGVTQQQNLLNQANAGVWWPNAGAPETRGAVYPPNTSWPPPGVIPPDGALVPMTTVPGRNDLAVANSFKSTGSKKKDSDSPADSDSIHTPTKEQRRGESPSEQRKTLDLDTRIAMLLKDKAGGMAPPFLQFGSDSEDERKSAADEEMLSNPPSPFLTNDLYEACFQKAQQRNKERRRVRENSLNQIPKSAGVDEDLGSIISSSEDEALLGSYSPTTAATGSKEPEPPKDQPQPPPPPLDDDRMSLSPLSSGDEKIEEISHEPVNQHLFTYPNVAHLHHYPAGAGVAAAAAAAAAATTNHHQQVYQSHHHQQPPPHPPPQGQQQWPRPAQYPFSYTIGATAAAAAAYIPGQYGQPAPAVAAPGLHGASVAGMPPLGPGTAGQNSGYYPNFQSRLQAMANHSITKDNPQGATIQAVLNRVVNELKQILKKDFNKKMVENTAFKLFDVWWDDKKSEKGVPLAGTILSSTVNNTATPAAVATNDATAVTVTAATAPTNNAITAVATAAVAAAKEEPKNHLSQRASLLEQATTPLGLNYEGFGLGIRASMPKMPSFRRKIKVPSPVAPQDEEDSRQSAEGRGAVENIVANAEAIDSDSDLDATLAPQKSATKRQIASLPSSSSSSSSSSTTSEDESNSSSGSSSSSDSSSSSDSSDDEVADTFSKAKLARDSQDPEILAVLRSLTCKTPENGPRTPIPKIDIFESAASYDFPQIEDFEEEDEEMAYSDTTETKEIKQEEEINNANETSAKRHASEWSDRAMVTPVTGVPIKQETMPATVPHDIKNMESSAIEALISLAGQDNKPPVTRVPSPVPIKPAPVVGNIIRKLQTMSDRYINDEPILKESEKIEMFSEIPTSESEEEESLEVRRQRCQAGLQQTAEARPRSQVCRVYLEHSYSLLPSQQQELLEQQKQVPSMQQPLVLTPSEVQPAKSTVVAQNLEKSDLKNLSSSVNKERMEKKKNKHVKINNNAVLLEKSHEREKENIRIPPSSFERLVPPSSLSESLPPSHHYATPTIYKERDLMSEMEILYEFLTRGIDHEDVEYLRRSYEALLADDTQSYWLNDTHWVDHPATDIPSPAKRRKRDEVRLHVTGCARTEGYYKVDLKDKLKHKHHYAQSIQRNEDVRESTGSGGRVVGGLDSSSSLAINGPKVNSKALTGKMQALSREARSNQRRLLTAFGIDTDSDLLKFNQLKFRKKQLKFAKSGIHDWGLFAMEPIAADEMVIEYVGQMIRPIVADLRETQYEATGIGSSYLFRIDLDTIIDATKCGNLARFINHSCNEEEIEVLKKELRSLYQLVKSGDFKVNDSTESDSIVSQAELDKVKKENEKLKMRIEILKKTLEERKSKHLAVSTNMSESGHMVSIYDTLYALFEKAIIEAYPDLTDPPVVISSSNNPKFGDYQCNSALPLCKLLGSVSQGKKVSPREIADKIILKVASSPLVEKLEVAGAGFINIYLKREFGQAILANILKHGKVLSPPVVQKRRILVDFSSPNVAKEMHVGHLRSTIIGDSIARLLEFLGHDVLRINHIGDWGTQFGMLIAHLEDKFPNYTTESPPISDLQSFYKESKVRFDEDEEFKKRAYACVVKLQAHEPKYIQAWKLICDVSRKEFQSIYNRLDIKLIERGESFYHSRMKDIVKELEEKNFLEEDEGRKIMWGENREGIPLTIVKRDGGFTYDTSDMAAIKHRIVEEKAEWVIYVVDSGQATHFQIMESCARRARIVLSCHNIDFVGFGVVLGEDKKKFKTRSGDTVKLSQLLDEGLKRAEQKLMEKERDKVLTEEEFNKAKESIAYGCIKYADLCHNRNHDYVFSFDKMTEDKGNTAVYLLYALTRIRSIARTANVSREQMQAAIGKTPISLEHEKEWKLAKVLLKFPDVILKITKDLCLHTLCELCYEIACAFTEFYDNCYCVEKNQTGEIVKVNMGRILLTEVTAMMLEQCFALLGLKPVEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK37</accession>
    <name>A0A232FK37_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aprataxin and PNK-like factor PBZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_006545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000095">
        <property type="protein sequence ID" value="OXU31035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK37"/>
    <dbReference type="STRING" id="543379.A0A232FK37"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09193">
        <property type="entry name" value="PLDc_mTdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09195">
        <property type="entry name" value="PLDc_mTdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU31035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="84766" checksum="FABA1F947380AA90" modified="2017-10-25" version="1">MALLVKRSYVPIRKNATGKILSISLKWHIRTKLVIDQLDETIMLPNDVGFECPDRSQLLDQLKVLQMVLKKEREKSGSTASSSSEKVATPAKASSRKSPKKAKELENLKAKIEKHKQVALQKRESKLMEMDAKAAKSDNKSDSQKMSKNRKRASPNTSSDSNPIKKAKSNEKIDAHNSSHSSVDSQSSSSLSSSSQSSIEQVTITTPKSYIENFVASNDRKLREKIRDQAVAKMRQGGHKVTLCEPGGFALKYALSAPYHYFFNRVEKSKVTHEQQFTVSFPELLDISLGEIVNSLHINFMVEIGWLCLQYLLAAQNANMTIICGSVCDPNISLPSNITLVQVNMPTAFGCHHSKISVFKYSDDGIRIVVSTANIYSDDWENRTQGLWMSPHLPPLPDSANPSDGESPTNFKKSFREYLNAYRNPKLVEWENLIKRADCSAVNVFFVASIPGSHKGLSLNSWGHRRLAAILNEHAVLPPDAPQWTIIAQSSSIGNLGPTFDSWIESNIVFSLSREKAQGIKSNPNFHFVYPSLRNYEGSFDCNAGSCCLPYSRKSHEKQDQWKADETGRTKAMPHVKSYTRISPDLTQIPWFVLTSANLSKGAWGTTAKTGVSHYIMNYEAGVVFIPKFVINQQTFPIKTSSSPDIPVFRLPYDLPLTRKEPIDLEKIKICRNENAEYGEKDYYSKRLNLSVSTWLKLYEQQISVEYRARLRDVSILMAKEFRGDNVYISEHGSFNTNRQRGTHTQSTILCSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKH7</accession>
    <name>A0A232FKH7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000075">
        <property type="protein sequence ID" value="OXU31241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKH7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="202" mass="20876" checksum="236E0B3BC31EFC34" modified="2017-10-25" version="1">MMLRGNLAKSPNEGGRESEAEGYRAAPPSHLEHHTTGALTAGDSSQNLIEVVAGRSSGEPSGNPEPSQGGQVGKGLDLQQPPAGAAGVSDTGVAGEGSQRRKREREGAPGARDATCPSSGSVPSSLAKNLTAGFAGADVRAPGVKLRKNADSPLPANQTARKQPNVEPEIMAARMMNPLTRTIVCEGYPDEELTHQQLPLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKJ7</accession>
    <name>A0A232FKJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ferritin</fullName>
            <ecNumber evidence="15">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_014196</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomer of 12 light (L) chains and 12 heavy (H) chains; L and H chains are disulfide-linked. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="15"/>
    <dbReference type="EMBL" id="NNAY01000096">
        <property type="protein sequence ID" value="OXU31019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKJ7"/>
    <dbReference type="STRING" id="543379.A0A232FKJ7"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000017">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF43">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="4 15" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012466587" description="Ferritin" evidence="16">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="17">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU31019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="24283" checksum="DC02E72153B28BD2" modified="2017-10-25" version="1">MKLFGAFFVLLLACVGTYGDSLKCHVAPADVPQSWKDMVSPCTKILEAQVKTEIEAAMTYLAMGAHFARDSVNRPGFSKLFIESAAEEREHAIKIIEYLLMRGELASDVSKLLKFPLKPIREEWNSGVEALTDALNLESQVTRSIRDIIMTCESPKDIPFNDYHLVDYLTADFLDEQYKGQRDLAGKISTLGKMMASHGALGEFLFDKKLLKKEVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FKU3</accession>
    <name>A0A232FKU3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000071">
        <property type="protein sequence ID" value="OXU31275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FKU3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325610" description="Protein sleepless" evidence="2">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17239" checksum="1C53258CB85E83B3" modified="2017-10-25" version="1">MFASRIAVVFALCFLLSIESVLSVRQCFKCDSRDDYECASNPKQAKFVDNCSNYRVQDSPGDSDIIDPKGNRSIAEYVCKKLVWLTRNGPNKTSIRVMTRSCARRGSCHASLKMSDVLESCDECGTHLCNSSSIIKAGFYGFIISTAMLLYFGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL03</accession>
    <name>A0A232FL03_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000087">
        <property type="protein sequence ID" value="OXU31128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL03"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="296" mass="33031" checksum="353E32F07B10CD70" modified="2017-10-25" version="1">MDPYLQSLIDSRKDALSCLKLSLDNVNQILRIVASLDSEISTSVSAERKNDNDASTLPPASAIGAVIGTDRLICQAAIIPPDGSSARTTGFQGRSRCRDKVDAVAEPSRQRRAEESRDKARREPDTSPAPAKDSFTSADRIKVEPVDDVVDVDNPSIGNDSGNLVGSSITSSDDDLADKQRRNVETSCRRSTRLQPMVRLEVLDDEDLQIGCKSKRKAGRPRKPRAYDEFLTDDEYEEKNRRYAIGNRRRKTRSSRKPVKILRDETWPSRIQPMRPAKSVSTPISVEIKDEDVNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL38</accession>
    <name>A0A232FL38_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL38"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="271" mass="28278" checksum="8DD11401D069901C" modified="2017-10-25" version="1">MEPNTKNLDEGGRESEAKGYRAAPPSQLEVEHPTAKPEGKSVKGNTAYNTLTRWITRAASTSKNLNSDPAVATTAGDSSQNLTEVVAGGSSGEPAGNPEPSQGGQVGTGVDLQQPPAGSNTRTDVATENLGSTTEKGGPDARDATSPSSRSAPSSLPKNLAAGSAGGDGRAPCVKRCKDADSTPPANQTARKRPNVEPEIMAARMVDPLTRAVVCGGYPDEELTHQQLALVSEAIQTEIDKIPNKPWPEFDDSFVKMRSIVVVASNAFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLQ0</accession>
    <name>A0A232FLQ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Immunoglobulin I-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000052">
        <property type="protein sequence ID" value="OXU31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLQ0"/>
    <dbReference type="STRING" id="543379.A0A232FLQ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14851" checksum="EEA668110A72715D" modified="2017-10-25" version="1">MTPCLAGRAIDSRRYKETCKEMSMLKYVIEEKREGYKVSMRLTIKGFNENDVGSYSCISSNSLGKVEGVSRLYKITDVNRHGLVRESHRISMLAGLSDAARGSGSKNMNNTDGISNFLQNFHFLNIFIMSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLV5</accession>
    <name>A0A232FLV5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000040">
        <property type="protein sequence ID" value="OXU31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLV5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7574" checksum="A51B0A1DE0712496" modified="2017-10-25" version="1">MLPLQSVAGVISDVAFFTRSPRWNRSRASRSFVLLVVYTYACVCVRERARERCGGTSWDDSSSRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLY5</accession>
    <name>A0A232FLY5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidylpeptidase IV N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000031">
        <property type="protein sequence ID" value="OXU31766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FLY5"/>
    <dbReference type="STRING" id="543379.A0A232FLY5"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU31766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="15061" checksum="4FEA9A286314AC8F" modified="2017-10-25" version="1" fragment="single">ETIQLTPHPEKDTHPYLLLAQWTPRGHGLVMIQDYDIYYRTGPLSNIGYRVTNTSIPGILSNGLPDWLYEEEILHSAEAIWMSKDSHMLLYASFDDSLVKEMRSSWYGDSKSLYPDIRSLRYPKVLSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMA9</accession>
    <name>A0A232FMA9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_010250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000046">
        <property type="protein sequence ID" value="OXU31588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMA9"/>
    <dbReference type="STRING" id="543379.A0A232FMA9"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="117"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU31588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="393" mass="44250" checksum="1770D54F84E82A3D" modified="2017-10-25" version="1">MIVAVFESALCIPKFYYGALFGLGFCVYYLFEVVKAPLVVCAKGPFRDFLEKNVPILKCKFWPTLWCFESRAQTVFASLLRSRIWPNIQYRREILTLADGGEVALDWAEHNCCSTSPIVIILPGLTGASEAEYIKCLVCAAKNVGIKCVIFNNRGLGGIKLKTPRLYCAANCEDLAEVIEHVRRLHPNVPIGATGISMGGLILGNYLAQHGKSAVGKLKAGFAISSPWNVFEATKSIERPYLNLMLNKHLCGNLRRNVELHFTEERDRLNLDLDTVMKSTTVREFDDYFTSRHFGYKDVEDYYAQATLHDKLHRIEVPLLCLSAADDPFQPLEAIPLKEVSETEHVAMIVTSRGGHIGFLEGIWPVKEEQYIGKIFSQFFSAVFWKGQEHPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMD0</accession>
    <name>A0A232FMD0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000029">
        <property type="protein sequence ID" value="OXU31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMD0"/>
    <dbReference type="STRING" id="543379.A0A232FMD0"/>
    <dbReference type="OrthoDB" id="7550162at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="330"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="795" mass="93896" checksum="6AD8E3547200074C" modified="2017-10-25" version="1">MNAVTCIAHKSQEFHAQFIFKHLIEKGCFPKFIALNDTKIMYIELSKGHQIRFIDSFNYINQNLSDFPKTFGFQDVIEKWRFPHLFNSSENQNYLGAIPDVKFYSPEIMSNKKRDKFIAWHTRLHRTNYRFDFQEEIVEYCKNNVEILRRGCYEFRQKFIKLTTVDPFIGKGIITIAGACHKFYRKKILQRNKIGIIPTGGYRAKLKRTRESLEWLLICERDIERTIMHIGHGHEYRLPELDVLVDGFDESTDPKTVYLYFDCSRNSCPTCQPILTPKHYKTKELKENIRNFGYQLEEMWSCRFKAIKANNETFLLNHDHLYSDALNPRDSFYDSRNENTVHFYSAKENEEIRFVDVNSLYPFLNKHRKYPVGHPKVKIGHDCDEYLDKKLFITQVEGLVKCRVLPPRKLLQPVLPIHSEDKYTLKFPLCKKCADASNACFCTHEYRGDREFTGTWVSEELKKAISMGYEITAIYEIWQYEVVEGLFGEYVNTFLKCKEEARGWHTEDDTTVKRHQYVEEYWKREGIRLDPEKMVNNKGLRRIAKHCLNVLWGKFGQKVRDTTNFGNSGNELIEIATSQYRELTNVVALNDYDYYYQWRYKEKYCKPSEKTSVPIAVYTTAYGRLELYKYLEKLGERVLYCDTDSVFYVQPTNKEEIIKTGKFLGEMINELNRYGKGSYIREFVSSGPKFYSYIVVKPDKSEETITKVGSVKLNSYNNDIFSHENMKKLAQGLLSSIEYESKETYPTEKHDVISRIVRKRVVKQSSKRFHADIDKSYPLGYKLSLLSIFKEYCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FN21</accession>
    <name>A0A232FN21_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000005">
        <property type="protein sequence ID" value="OXU32136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FN21"/>
    <dbReference type="STRING" id="543379.A0A232FN21"/>
    <dbReference type="OrthoDB" id="7695999at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="15076" checksum="298AA76B1226B94D" modified="2017-10-25" version="1">MNLIEFTIWGQDLLLLIVAHYNKNLYNREKNKRDKYKKRRERKSQKLGLTVAACGSNDEISNNPMADYRRLSCPSCGRRYKYRGGLLRHIAECFSEAEKVEVLNIQHQQQQQLTAKDVRVLYKFWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNJ6</accession>
    <name>A0A232FNJ6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000015">
        <property type="protein sequence ID" value="OXU31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNJ6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12723" checksum="2CCCEDA0CD8DDF68" modified="2017-10-25" version="1">MSALWRIGHSRDEIPQEDPDNLAHDRRKDTNGGQYALTEAELERVRLTLRDNLFQAVCKLPALLDFDISEQSLRNNIKKRLNLKNRKTARKSIITANDQQIRLAYANEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEC5</accession>
    <name>A0A232EEC5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_013589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005393">
        <property type="protein sequence ID" value="OXU16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEC5"/>
    <dbReference type="STRING" id="543379.A0A232EEC5"/>
    <dbReference type="OrthoDB" id="7699767at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF29">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="298"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="478"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="565" mass="64549" checksum="C698F68EE95D9480" modified="2017-10-25" version="1">MTWKLESRYNIMKEAFIKELEDVPYYCLTVDNWTDSSNQSYIGITIHHVNNSAMTGRVLGCFPLYENHTSEYLMKSIQNIFDDFKIKKDKVTAMITDGASNIKKACIDLLGKDKHLVCIAHVVSHLLPDALNNFKELNTIIDKVKAIVTQMKRSIPASDKLKEMQLKDGKTEGTILKLKLDVPTRWTTKIEMLERYILLEPYIYNAINKCEKPLNLLTREEISIVKDILPIMEPIKTVITEISGDDYPICSLIIPIINCMKQKICSTVPTTETFMIVFWNNISNLHCYFLASDRNIEIEGYMKLQLLSKTENIFVYWQNLQVNFLVLSKLATPVLATLATSVSSERLFSKAGNTKRDRRNRLTGNRLNILLFLGNCTLEEWFKISIVKDILPIMEPIKTVITEISGDDYPICSLIIPIINCMKQKICSTVPTTEPVDPKPKPIAVNTVNTNSIWDIHDSILEQSQQSTLSFSASDTNIEIEGTENIFVYWKNIQVNFPVLSKLATCVLATLATSVSSERLFSKAGNTKRDRRNRLTGNRLNMLLFLGNCTLEEWFKLYNIHTLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFF2</accession>
    <name>A0A232EFF2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005062">
        <property type="protein sequence ID" value="OXU17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFF2"/>
    <dbReference type="STRING" id="543379.A0A232EFF2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="564" mass="63485" checksum="7A7AF6E9D72D6D50" modified="2017-10-25" version="1">MTFSANTSSYRNIFPQDKTIELNQAVYSGYRQLVQTMLTVDKLDVNFTPNGRDTYLHTAIARRDLAMVQLLVMFKANLNPLLTARDAISPLWMAMLYSYDDISEFLVRAGADINERFSLHFCGKKCNYTINGINGGKTSLLHLAVARNHEAHVKLFLDYGADINYQDTFGKESALQYAVFRKFISLATILIYRGANLESANVDGMTSLHTALIIGDVDLIKMLIQRGANVKAVDNSGKTALHFIAESNVENVEIAEQLLNMGLRINQTEFKRNLGPLHVALLTGKDKLVKLFVRHGADVTAKISNGVSPLSLANLYCSAKTMRLMIARGANVNDKIDDGGTTLHMAARRYSAEKVRVLLRCGANINSLDLRGSTPLGCLENFHSDVAKVLVKQIAIMHARGAFIALSTMEVIWANVPLMEHFNQCLAELKFIEKKPFYLRYTLRTVLDERPMKLAALTRNSDFVLGFQTIKLKLEVPNFAREICIKFMCALLLKYQLSSMEEHLNRIFYDSLPEPIIQAIAYHMNIQDTPYLVERLVRAIRQVQEKARRARRELATEETIGPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG56</accession>
    <name>A0A232EG56_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004847">
        <property type="protein sequence ID" value="OXU17345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG56"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="80" mass="8747" checksum="F6A2F235F4B47E89" modified="2017-10-25" version="1">MSRRVQCDGSRGATTECLPCKPEDLGSSPGSVTFSLHSSLVTVATSEITTIWIHIDILGIKHILLLPICYITDITIFIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGK3</accession>
    <name>A0A232EGK3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004746">
        <property type="protein sequence ID" value="OXU17477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGK3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="100" mass="11064" checksum="2B0575F9A56FF844" modified="2017-10-25" version="1">MAFQTLSKLMPDMPERCSIGTDNKRSRIISEKVGNLELGLCSQSFARTINFRDNKAASPGSSSISSLDRRRTERGVAAIIIVYVQIQKKPDTFGGLSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGX4</accession>
    <name>A0A232EGX4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004648">
        <property type="protein sequence ID" value="OXU17607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGX4"/>
    <dbReference type="STRING" id="543379.A0A232EGX4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="264" mass="29733" checksum="21C4D5C18EFC7ACD" modified="2017-10-25" version="1" fragment="single">VGLDIGGVSGTTLGYISDFLHNQLNSLKTEDMKFQRSQECADRKNCEIDVLNFEDRTALRIIVIRKRLECVAELLSHLANINIVDKKGNSALHLAVTRSTPMISLRHLVDKDTNEGQKILYILHAVGAKRCSFDMKGCSIGCKHNEIFYGVAPPTAVSRTVFDQMLYVSRMEKVATKKRKHTKGVQLLCQCAAETCIEPFRLDFWYFHWILTLGIAAGKNLKECQALYFSINDNAFVGRRLYDSEPLKNALKETLGEVTVMADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EH09</accession>
    <name>A0A232EH09_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_002666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004618">
        <property type="protein sequence ID" value="OXU17646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EH09"/>
    <dbReference type="OrthoDB" id="7701518at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU17646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="217" mass="24116" checksum="F2BA94AF32BCF5A8" modified="2017-10-25" version="1">MQTTIRSLTAKYQRVLFSNIAPPIPHSVLEDIIECLGIKRNAPITTLKASLTKDGFSHVLSSRRQTYIDANDVKNLPELIKITYEEITYYIYPSTDQLKCFACKMEGHIAKHCTNNLEETDNNNTQIPNHILPEENSKDSPLIETTINNTANVGIISEAKPTGPTTPFLEDTTATENDHHNKMPPAHATRPPGSSTSTSTEDGTNLKPPTKKNQTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHV4</accession>
    <name>A0A232EHV4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004400">
        <property type="protein sequence ID" value="OXU17949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHV4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="135" mass="15724" checksum="9FEFADAABA0DCA3F" modified="2017-10-25" version="1">MRINIDTLPQLTINGIAIRFIKLTKNLGMKLAEDLSWNSHISAICSRVHGVPNHLRFRTYYLSSSLKKQLVTAFILPHFDYPFIFRLPRDALLAPYIAKLVWFTPEKRRKYFLAVILYQILTIAKPPYLTAFFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHY7</accession>
    <name>A0A232EHY7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004377">
        <property type="protein sequence ID" value="OXU17980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHY7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="152" mass="16962" checksum="84B1D97A432FB494" modified="2017-10-25" version="1">MSARNSPESQALCSGWEVRKSKGRIGPYRVLYPGKGALKILNKIRNAKREGESIWEKIRDRLDSIDNVVLNASNIHKSVKSNLSAIMSQVEWLERGQVTLEKSKESFGLMLSKEEMLPNQQHIQKEAKALQCDVANVAAASRRGISFDAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI14</accession>
    <name>A0A232EI14_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004366">
        <property type="protein sequence ID" value="OXU17996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI14"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="10043" checksum="18F7FF1CDD32051D" modified="2017-10-25" version="1" fragment="single">ESSASAAPVIDRRFAINWAWIFLNKRKAALLTDLQAPNNQFSMRTLSRKLRDRFFSDLPTFREKLCSDFGVGRCDRDTSSRQTNLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI35</accession>
    <name>A0A232EI35_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004376">
        <property type="protein sequence ID" value="OXU17982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI35"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39930" checksum="86C8D5106163410D" modified="2017-10-25" version="1">MRTFATGDPFFVNLKGFLTSLRGNAKEVSPSNNSTGSQIEENVDTELDDTETIIQEGANVDENGVGILQHALNQSFLYAGQYAAPEETGNEEDLAIDPQLLHRTENNESENDNEGNHAAGVRMQDREINENDDNNRNAAQVAVNQNQTNMCAPVNQNRRNSIAYLQEENHHPDKCCIGCKNTCIHILKSLVELKEAIQNNPNMAIIPAPTFDLLPRLPFENVEDLDDFDERLGDPREADMADQFEKLLASKGGNTLSKIVSKAMSAFITDELCKKITWTGVKDTLKAEIMNFPSIVIKVVRKQFACKDSEAEEQIKDWLRRPSDRIAQAAKTQRNKMMRQERRLQRRGNRQNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EI64</accession>
    <name>A0A232EI64_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_005564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004314">
        <property type="protein sequence ID" value="OXU18060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EI64"/>
    <dbReference type="STRING" id="543379.A0A232EI64"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01269">
        <property type="entry name" value="PTB_TBC1D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000043">
        <property type="entry name" value="Pollux, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2750:FF:000002">
        <property type="entry name" value="TBC1 domain family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021785">
        <property type="entry name" value="DUF3350"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF16">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11830">
        <property type="entry name" value="DUF3350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="656"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1116"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="938"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1042"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU18060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1269" mass="142399" checksum="8D95CE309FE8C54C" modified="2017-10-25" version="1" fragment="single">VQELFGAMKEQSSSSRIERDRDRDLPQRSLSSAAALTSIGADISPSSSHFFEVLYVGKTKIAQSKVPESFIDDVLVKFRSHGLEKSKSTASSLLAECHQLKQQSSASNIFANIRRDSMDSNTSDLGSVENVATSPTSPLVPGTTLSGSIESVQPSAPEPVKPSENNLAPLAKKTNSMPLPEVAMRNRAASTGSVMLTRRDSSLKENEDLNRTMLFQVGRLDLRLISPDRKKVLLHKQLHDVASCVQGIKNPEHFGFICRDNSAERFVGYIFKCQSESVADDLVAAITQAFVASCDGQPIRKERQPVFSCEHCPMVWYSRLCQEVEGQSDRKTQNIIFSRLEMLPEDEQEIVVTKYKGAEAANGTGSGMTLAEQNQFLMMLLRAHCEAKQTRHVHDTAENRSEFLNQYLSVGVGSTIFMKAKRSLTNSFDHLMKRKGSKDDFGLGSQNHLNAVQKPGLQSPLSGSGPLPIVDMTPESNRPRSLRVSPEQQIAVNVASPKSPMMDIFLKVGNSPKMSPTEGEGSNRLQQSGSWRQAILNRVVTPGKDQESKEASKNATLNPSGKAQAAPVTKRSREELRELWKKAINQQLILIRMEKENARLRVRQEEATVKRIKLEYDELNSCNRQLVEVWDLLVSKESRISTKCDSQMLLQAIKQGVPRGKRGEVWQFLAEQFCMKQPPLDTRDFPNYNTPYELLLKQLTSQQHAILIDLGRTFPNHPYFSSPLGPGQLALFNLLKAYSLLDHEVGYCQGLSFVAGVLLLHMSEDLAFFLLRHLMFRRGLRKLYLPDMAALQLHLYQLSRLLHDRLPAIYNHFDKHEVSPTLYAAPWLLTLFASQFPLGFVTRVFDLLFLESSEVIFRVALALLEEHQDQLLCCDSFEEIMEYLKTKVPAVDKVTLDRVMKRVFYPDMEMAKQLNEYRVEYQVLQEEMISVKPQIENMEKLELLNKQLTQQNTHLNEQLEIAMANLHRMETTRAHHQSTVHRLESQNRSLEVTVCTLGSFIQQVIDSGTDIEIPGDVRRIVAQLSLAEKRRNNNLRSFPSRIPEDNNNKYDMKKSNSTGKESRLIKTNSMIEPPYPLKSALSQPNLGSKLEKVSSFFANSHNHIKQQRAQIAAIRSEGGSNETVSSNGGNDENDPKTVNIDIQITDTINTGLDNNVTQNDSALKIDTLANLEKSISLPRNAKIQLKSSKSAYELGSVKKIPTTKLEDTISDSLTNLSGTMHPLDTCSDVNFKYGGTTKLKSIKPIRAGGQNGQPDNNKEIQQNPQILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIZ9</accession>
    <name>A0A232EIZ9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004132">
        <property type="protein sequence ID" value="OXU18325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIZ9"/>
    <dbReference type="STRING" id="543379.A0A232EIZ9"/>
    <dbReference type="OrthoDB" id="7697359at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23935" checksum="20809662906C7B0C" modified="2017-10-25" version="1">MFSDESTFNSIGHLNRHNSHYWSAINPHGMQQIDNQHRWNINFLCCIMNGNLMGPYFFEGNVNSESYLNLIENELPILLEHVDMNTRYRMWLQQDGAPPHYARIVRNFLNDRFPNRWIGRGGPIAWPRRSLDLTPLDFYLWGYLKDTVYRERPTTANDMRMRIQNACANIPRNVLIRTVEHFQQRLQLCLQVGEATFEHSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ28</accession>
    <name>A0A232EJ28_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_000536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004138">
        <property type="protein sequence ID" value="OXU18318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ28"/>
    <dbReference type="STRING" id="543379.A0A232EJ28"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU18318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="284" mass="32425" checksum="E2BF557B3ADEBB17" modified="2017-10-25" version="1">MSCISRISLVKLLQPFACKTSVKFSTAASVDNVANASYTSEIEPIISTKKYLDEHKFYIKPRQAWIENLDTIEEKKLGLITLHPDIFGALPRVDIIHENVRWQQLYRYVSYANTKVRSEVRGGGRKPWPQKGMGRARHGSIRSPLWRKGGVIHGPRSPTPYFYMLPFYNRVLGLTSTLSVKLAQDDLHIVPELEIPSDEPSYMLELAKERKWGPSILFIDNNDIVPQNIAIATNSINHMNLMPVYGLNVYSMLKHETLVLTESAVRLIEDKLLFHLNKINVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ32</accession>
    <name>A0A232EJ32_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004100">
        <property type="protein sequence ID" value="OXU18363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ32"/>
    <dbReference type="OrthoDB" id="7697906at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38328" checksum="D78F083DF076D840" modified="2017-10-25" version="1">MGPQPYLTFEGEEKIVYWINNLRKCGFPKIVEAGKLKTPFNNNKPDLSKRKAESISKGRAIITEEIIRNWFRGLKSFLQENNALEILEDLSRIFNGDETGIQICQDQENDINKVEQIIKSIAPQLLSRGIDTDVIVEEPRKIQSSQANGQSDLITETESNPQGIQVQSNVDEISLNANNIEHSSQEYQNQSRSDDPQPDIRGTEERILEVSEHERINAALNTVDMEFVKDELDLSFFNEDNLQELVFKNNEMFNDNELELVLDDGTVQMVPIIDLTKLSAANTVVHNINSDYNLSTCIGLGTDKDKNSEQSSISTYLANASNASSKTNTRTDNKKGRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJY7</accession>
    <name>A0A232EJY7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003910">
        <property type="protein sequence ID" value="OXU18670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJY7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12962" checksum="514910016E0BE740" modified="2017-10-25" version="1">MRTSTQHHGTHCENVDTTMRRSLFNYDITYIRLYTRKQWLAPVDNGISRTFCLSFTVVRSLCQRAKADSQLNCFSKVKVTDNNRIIIGIISYRLFCDFHAQYINIVQYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK10</accession>
    <name>A0A232EK10_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003914">
        <property type="protein sequence ID" value="OXU18662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK10"/>
    <dbReference type="STRING" id="543379.A0A232EK10"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="351" mass="40597" checksum="471DB3A88743ABBC" modified="2017-10-25" version="1">MVICGGQQIIIKYFLRTPVDWSLSKRIIGTPPKIIALEYGRLDILVRLLKTEKLDERKTAYTNICGSNSLHYAISRGNYKATKILLEAGANPNSLDHFDQTPLEKACRESPEILNNHNPTERDLSPLPLRKTKCRAAIERRDRHKFTGSRRQMSSIHQNDDVLGTLINYKADWRVTCKPGENALHVAVGFGTPRALKIILERGNCHLDERNLLGATALKIAFRADAYEKMDTLLQKSDIRRTTNVENKITLKNYHPVLYKDFENACLEWQRTIETTFVREITFRDLVRKPISHLLEMSGTFAFQQQEGKFYYDRFPIYGSVIMKTTRRTSFQTEKFKNHSSKTKERNNTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKG8</accession>
    <name>A0A232EKG8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003817">
        <property type="protein sequence ID" value="OXU18811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EKG8"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17231">
        <property type="entry name" value="TGS_DRG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000016">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="62"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="370"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU18811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51852" checksum="8CAE5687D456F3D6" modified="2017-10-25" version="1">MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRSQLLEPSKKSEKGEGFDVLKSGDARVALIDFPSVRKSTLLSTLTHTESEAASYEFTTLTCIHGVIEYKGANIQLLDLPGITEGAAQRTTSHSCSKNRRFNFNDVGXFTTLTCIHGVIEYKGANIHLLDLPGITEGAAQGKGRGRQVIAVARTADLILMMLDATKQDVQRQLLEKELESVGIRLNKRKPNIYFKIKKGGGLSFNSTCIFTKLVQMILHEYKIFNDEVLFQEDCTADELIDVINANRLVQMILHEYKIFNAEVLFREDSTADELIDVINANRVYLLCLYVYNKIDQISIEEVDRIARQANTIVVSCNMKLNLDYLLETLWEYLTLIRVYTKKPGQPPDFDDVLILRRGVTVEHVCHAIHRTLAAQLKYALVWGTSTKYSPQRVGIQDIMHDEDVIQVMKKNSVLPMNTTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKI3</accession>
    <name>A0A232EKI3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003789">
        <property type="protein sequence ID" value="OXU18869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKI3"/>
    <dbReference type="STRING" id="543379.A0A232EKI3"/>
    <dbReference type="OrthoDB" id="10460776at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="571" mass="64165" checksum="AD894471A0BDAB36" modified="2017-10-25" version="1">MNTALYVLILHTFSLPLRFPHFILNTSKISTRVRMTVIKVMNLPIRITYSMLHNKGYHFLKRGIWLELNQNIERKKISSQRAKRVLKKVKDKFEVTPFVDVLPNVSCSSSTLGENLNPVVHIKKLELQGKKPVIQSSPESPSLLAPLRRKPLQLKKLEMQAKKPGQIQSSPESPSLLAPLRRRKPLHPRLKFSISPESSRGSTHDLATPQNKSPSRSPSSGSTTSDLSPPRKKSSSHTVALRSTIPTHNAPNGQPSPARSTTPAFDQPPAQPSPARSTTPAFDQPLAQPSPARSTTPAFDQPPAQPSPARSTTPAFDQPLAQPSPAPRSTTPAFDQPLAQPSPARSTTPAFDSPPAQPSPARSRTPSLRNSPPAQPSPARSRTPTLRNSPLDQPSPSRTRTPTSNSPQYVKECIEYYSKRDKPGYEEFRKRYDIINGNMIYLGEGFSIETLQWDLLQTHKPQIFLIELSVIFWGEKDLANRALDLTRGVKNIPNRSPVKLIEKEFLRLLISIYNDYLDRRGYSGEEKISFLLKTTYVIRHKIRDLRQAEIKKVHQAHAPNPRRRLRYNVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELS0</accession>
    <name>A0A232ELS0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_001543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003522">
        <property type="protein sequence ID" value="OXU19268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELS0"/>
    <dbReference type="OrthoDB" id="8185744at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="259" mass="29491" checksum="C256709B8EE101AC" modified="2017-10-25" version="1">MDSIKRADSTHSISSIVSDSSPNNDDPEIKTKTNSMLKLILEAISDTNAESSALGNEVLELLNILKFDTKSLPTDIREGLQTTSAILKSEGLPAVDETALQLCLEKKKIQSKMKEREERLLKAKYNAAFAKYNALQEKLNRIRKEIEEIEDTLQLKMSNDENTESDRILWSNRLHDYKDAIKKMEQELDTLQSKEIGLDSTLQKSSLLMNKLNDLSQLNSSLKRYGDLPPNLLQAKIMLESKTQELEEIENLIYEKMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMY6</accession>
    <name>A0A232EMY6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipid-binding serum glycoprotein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003253">
        <property type="protein sequence ID" value="OXU19729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMY6"/>
    <dbReference type="STRING" id="543379.A0A232EMY6"/>
    <dbReference type="OrthoDB" id="6412801at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF13">
        <property type="entry name" value="FI04421P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325590" description="Lipid-binding serum glycoprotein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53024" checksum="B972F25129D862CE" modified="2017-10-25" version="1">MAREALVVFASTLLLLILSCQSARSEDEAPAATSTSAQIAQGEKRLGDQIRAILKHYQQPDPIGLPGAPIPDPMDVPNMKQSFSMFTMNLNSIKVYGLSKFRIEHIRSELALMQVSVGLDIENLDIKGLYTLSSWISSSAGDFTVKLLGVKVEGLAKLEVGNDGKLHAQDIVMDLTFENIDLDFKNLGFFASLFQGVINSVGSFVFDSVKPYILQEVNTNVRGEVNKHISTLPNYFPNSISPFDMAVAEARKQVSDMGYDPFKVKDYSQSMGMFTVTSSHTWLTGLASFYRMGNITLSMENGIVYAVMDIGTQEIEGRTHWDVSVIGGVLSRAGTVSFTVEYFRVQLNLSQPLDTRKRATLEELDFELGNIQTRIHGAGTIDYLVEAGVNILPNLLRNQIMDALEGPIRRRIQDELDKVNVEKLIHEKIPDIEERAKMLQGPTLEELEDDIVLEVTPPPEPDNQEPFSESEEERGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENX3</accession>
    <name>A0A232ENX3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003050">
        <property type="protein sequence ID" value="OXU20054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENX3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="262" mass="29293" checksum="25FF00E4CBC5E07D" modified="2017-10-25" version="1">MTTSTRSVREKAAISKLQLSNVNKTNIAAVGKLILNQSQTHQYTTGREILVRPDEIMTSGAGNALGSVAQWTAAKSQETKLPPLNREQQGQNKFSRFCLSFSRHCKLPWQLYYASSWKILKAASGFSKATMRRAVALFLVLSADNALTESILTGRQAPVGCEQVHSISEWILADSARIWPGRGFNKEPLTLNYKSVHPTINENFVNIDGNESSFVIQWFLGPLNTNIVTATLSEVPGSQGKQYQRRIQEFHGKLMKYFVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP62</accession>
    <name>A0A232EP62_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_005452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003020">
        <property type="protein sequence ID" value="OXU20106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP62"/>
    <dbReference type="STRING" id="543379.A0A232EP62"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="31"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU20106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="603" mass="65969" checksum="36DDC6C3F01F87E1" modified="2017-10-25" version="1">MQLRGRCGGRDLLRRRIPIIGWLPQYSWGKLLQDALAGMTVGLTAIPQGIAYAVVAGLPPQVYNIAVLKHYSKLRVCTRFQYGLYSSFMGCFVYIFFGSTKDVTVGPTAIMGLLTQPFVLNYGDDFAVLLCFLTGCLITLMGLLRLGFLVDFISMPVICGFTNAAAIIIASSQISTLFGISGRSESFIDALKKLVEHFLEIKLWDTLLGVCSILILVLLKNLPGKRHGGNGLQKCMWLICLARNAIVVIAGMVLAYCLSLYDDGKVPFNITGNITEGLPPFQPPPFSTTHKNETYSFIDMMNVLGSSVISVPLIALLESIAIAKAFAKGKTLDSNQEMIAVGLCNLFGSFARSMPTTGSFTRTAVNNASGVKTPMGGLVTGALVLLACGLLTSTFKFIPKATLASVIIVAMYYMLEIRMFRLLWRTRKLDLIPLVITLLVCLTAGLEIGMIVGIAANLVLLLYGTARPGLLIEERAVNEIPVLLVTPQQSLSFPAAEYLREQVMSWCDTIQYTNIVAIDGRNVMAIDATIAKNLSLLHNDLELRKQKLIFWNWREDARKTLVAFDGSIDSHFRTCGNLVQLVSEEISNSAQLPIMTRSQDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPA9</accession>
    <name>A0A232EPA9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002992">
        <property type="protein sequence ID" value="OXU20157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPA9"/>
    <dbReference type="STRING" id="543379.A0A232EPA9"/>
    <dbReference type="OrthoDB" id="441971at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="220" mass="25960" checksum="3265432609F68D16" modified="2017-10-25" version="1">MDDNIIHFVSNDLNLSTGTGKLLTDIKAIYQEDLVKAGAEVREVICTIYRKRYVFSLVITNNTGDEHIIRSLTDFLRDRASIKQDYDKEVPFAMHEYNTFTGYAFELVYGRPARTPNKLSDEYELRVTYNAYIQNLTECLREMQTITRGNLIDSKYKNKQYYDKKARSLEIEEPKYGKLDKYYNGEFIVKEIRDNNNVIVESTNRKLIVKHKNKLEKFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPZ8</accession>
    <name>A0A232EPZ8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_010144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002894">
        <property type="protein sequence ID" value="OXU20376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPZ8"/>
    <dbReference type="STRING" id="543379.A0A232EPZ8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU20376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="219" mass="25148" checksum="A8681BD1110E1A91" modified="2017-10-25" version="1">MDSFHQLMTLINQHSPDDDQPDLDILKNLPLEIVLIILSKLDNDSLLNCALVSRKWLSLCKSSRSLRRKIRLHIRSKENVRSFNRSTIRSSSTSTLDASSTSFDTSRPSYRPIPPQRLPANHPIVIFDDSSIPNDTSQPSSSQSVSQQPPTRRRRSSSTKPVLKKTSHLRFHQKTLILKSTPFINKASLIKIIIFKSLHFKYHKAFITSIFHKKRKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ63</accession>
    <name>A0A232EQ63_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002838">
        <property type="protein sequence ID" value="OXU20462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ63"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU20462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="53" mass="6750" checksum="9D14BE60BCBCE63D" modified="2017-10-25" version="1">MPIKFDMHIYFWILNSGKTFILYYFNYFSYGQFLIFEKHYFAFFSINRYNQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQN1</accession>
    <name>A0A232EQN1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002735">
        <property type="protein sequence ID" value="OXU20665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQN1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="27" mass="3128" checksum="BC2587D7529F18FD" modified="2017-10-25" version="1">MVNRPLSRFLLSMPAPGLLTQQYRQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ES71</accession>
    <name>A0A232ES71_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_005182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insect beta-1,3-glucan binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002525">
        <property type="protein sequence ID" value="OXU21136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ES71"/>
    <dbReference type="STRING" id="543379.A0A232ES71"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02179">
        <property type="entry name" value="GH16_beta_GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2140">
        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031756">
        <property type="entry name" value="BGBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043030">
        <property type="entry name" value="BGBP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035806">
        <property type="entry name" value="GH16_GRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15886">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51969">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013053851" evidence="6">
        <location>
            <begin position="23"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="CBM39" evidence="8">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CBM39" evidence="8">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="306"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU21136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="582" mass="66525" checksum="62633F11D0256B9F" modified="2017-10-25" version="1">MFTLSAFRFFLFFLISAHLSNAQYVPPEALVEPLTPVGLRISIPDEPGITLVAFHVKFNQEFNGLEAGTIARDIMKPKNGRWTYEDKSTRLNENDVIYYWVHVVYNRLGYNLLEQEHTVTDFYEYQDSKPTTNAHFVVPEALVQPLTPVGIRISIPDEPGITLVAFHVKFNEAFNGLEAGTIARDIMKPNNGRWTYEDRSTKLKSNDIVYYWIHVVYNRLGYNLLDQEHRVTDFFNYKGKIQPQMDNKGGDFKPRPCVYSTTKLFDKAGFSKNPCAGQLLFKEDFRDLAQLRRSQWTIVEQYPGSPDYEFVVYRNSPENIKVENGLMITPKLLRNEFGANFVREGSLSLINCTGRFLTAECYSKARGWNILPPVTSGRVNTKNSINFEYGRVEIRAKLPRGEWIYPLLLLEPARNMPGSPLEAVQIRIASSAGNTELRLRDGSDIGGHLLWGDITGLNPQKSENHNQNRPIIYNQELWSDNFHVYELIWSPGRIVLKVDGQVYGDKSVNLPSDTPFYLTLGVAAGGRSEFPDNSVSRGFAKTWRNVEAKAMYHFYKATDIWYGTWQNGATSLSVDYVKIWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETZ5</accession>
    <name>A0A232ETZ5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002196">
        <property type="protein sequence ID" value="OXU21835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ETZ5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="107" mass="12695" checksum="6AAC99F2B8DAA5A3" modified="2017-10-25" version="1">MRRENYIHETVTDAFYRRPLFNIRIRLLSSRNWGLIIDYKTNLIRTAECALDALELLKMYEEMLNGLKAMKKIDIKLIQYPIDNKSGEKQVEPPVNLDIDPFFFNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUF6</accession>
    <name>A0A232EUF6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002130">
        <property type="protein sequence ID" value="OXU21995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUF6"/>
    <dbReference type="STRING" id="543379.A0A232EUF6"/>
    <dbReference type="OrthoDB" id="7700731at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="299" mass="33213" checksum="51B219C51E25087D" modified="2017-10-25" version="1">MDKDELQELCGRSRGRAMVTGAAGLLRRSTRMSGQLLIGVIFVCCFISVQLVLLLLVFAPGIATFARHSNCSTSRTFDNANTSVYFVKHQDKIWTSEELCSIETAAHLYPQYNIVIVNLLRDNSPIAVSPEDNVDITRRLAKKLSNVRSVDTSARKFFAKSVMSKRIQADDLRSEEIESAAKFQLIWDSPGVSLEPLLVHQLESIQPYFADKDEVDLDASVQIDADFQATSVPCQSFIGFVLDRMAKPATSFADRRALMESTLSQYCNRITGCNGVRIVKSISKKLFNVSCPIVDSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUM7</accession>
    <name>A0A232EUM7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_002562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01002109">
        <property type="protein sequence ID" value="OXU22055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUM7"/>
    <dbReference type="STRING" id="543379.A0A232EUM7"/>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF21">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="245"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU22055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="519" mass="58560" checksum="ECA5AA1C9A182766" modified="2017-10-25" version="1">MSLNLVKFFSKKKHHSPQPTDTVGEIGLPTNVSHQFHVIKNAETGQLEGLPDSWIRLLNTQITKSEQDEHPAAALQAIKFYNYSIKKKPTPQEEVFKPFVTEDVIEEESIEIDKILAKKCNANHRDSDGSTSASSTDSQVQRLPPDLPPKIKKPPKPAPRKFVERKEKTFTEVLEDLSNCQLDDYDLLPEDNNGNKPAVESTVFKQEESPVLRRKTNSSIPTLSDEEVYKELRNICQSDDPQLRFERSKEVGSGSSGRVFIATDLSNNQRVAIKDIDLEKQIKKELMLTEIKVLKEFRHPNLVNFLNSYLVDDHLWVVMELLEGGPLTDVVTETVMKEAQIAAVCREVLKAVSFLHSKGIIHRDIKSDNVLLGMDGTVKVTDFGFCANIVGDEKRQTVVGTPYWMAPEVVTRKQYGKKVDIWSLGIMAIEMIEGEPPYMKETPLRALYLIAAIGKPQIPSWETLSPKFQKFLEDCLAVEVDERASADELLAHAFLDNCAELTTLSPLIRAAQKILHKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUV1</accession>
    <name>A0A232EUV1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002087">
        <property type="protein sequence ID" value="OXU22121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUV1"/>
    <dbReference type="STRING" id="543379.A0A232EUV1"/>
    <dbReference type="OrthoDB" id="6506078at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21453">
        <property type="entry name" value="DLC-like_DNAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000002">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 12" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11777" checksum="FDBFEBFAD0B2528D" modified="2017-10-25" version="1">MTEVKKDDVVKILHSYPLCRKCDMTDEMKQEAMELCVTAAEKYADNYESVSRMIKETMDKKFGASWHTVVGEGYGFEITYQLKHLLYMYCAGNLAICIWKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EV61</accession>
    <name>A0A232EV61_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transcriptional regulator ATRX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_014750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002050">
        <property type="protein sequence ID" value="OXU22240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EV61"/>
    <dbReference type="OrthoDB" id="9900844at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="657"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1013"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="458"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1268"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU22240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1313" mass="151817" checksum="5414CB3EBAFA32FA" modified="2017-10-25" version="1">MMVILEETYKTAYIQCIIDTAGELHRIATNISSDMDMVISCAKNELNNLDDVKNTAKKVLTVFLSSEEIINTARHNFLHSYHQWLEDCLKVNAVLLENTILKENQNTKSLPSFKSIHDKYIIEIEDSYGSDIEIVNEVRYSKSRKTDNDSDENEEIASKSSGKESNNAVFINESKKKKSTSPTFIQNESIIISDDSIVSDENNLLSKKNECFNSSIDSVETYFSPSVCNSNVAVPTNTNFLSDKRLNSNCVVVLERLSEENYKYKKESLPTKNKKFIDEYEFARLINLDDLEKPRNKRCYIFSDESSTNESSNSSSPSLSNNYKVKRKKKKFKTSASISEVSSFYYSSDDNSEKRSTNKNYYAYNNDLNVDKLLIEQNEESVKQQLLRSDDSTDFELDQDDSNDNDENSRHEKKKNKTKKAVQNLNSDSPGSDDDRRAKPEWTKDKVLNFKLNDLDMNEKTKTGKNAIPMKTDSDNDNDLKPIIVKKRRNKRNPLNVSQSLNSTDKSSLNNSFSDGSDSEDCQIVRSSSQLSATSQVTGILTNSEEQVVVSNAVTPSKPAGRRNIRKVFHDEEVAEGTRRAGKDEENRLQRLAERKKQLQELLTEKNKEKDTLVLDFDIDKKIDLIKVDRGLVKFLKPHQAEGVKFMWESCFETLEQVKNSEGSGCILAHCMGLGKTFQIVTLVHTILVNRDTGVNTVMVVCPMNTILNWVEEFDMWLKHAENNKRIRVYDLTQIKKTSSRISQLKFWHDLGGVLVLSYEMFRLFTSDDKKRSLQRSQKMRSYLLNPGADFVVCDEGHLLKNEGSQIAKRMQCVRTKRRVILTGTPLQNNLSEYHCMVQFVKPNLLGNKIEFLNRFGNPIVNGQFDNSTAKDVKLMKHRAHVLHRMLEGCVQRCDYAVLTPFLPPKQEYVILLRLSELQIEMYRFFIENIARADANHCRLFKNYHEIKRLIAHPTNMQLQAKANQKNNKTNMNNKAKNLPNGDFSQAEEKYWWSRFVKDDQQFDFTQSYKLIFLYGILERCKKEGDKILLFSQCLNTLDLIEIFLKHIDSQSKQNGFTNDLFNFQDEWKRGLDYFRMDGSVNSEKRNSMCKTFNNPNNKRARLFLISTRAGGLGINLIGANRVVIFDPSWNPSNDLQSIFRIFRFGQSKPCYIYRFLSAGTMEQKIYNRQVTKLSLSLRVLDEHQIERHYRDTELAELYKLETLDDQPILNMPKDHVLADVFLKFKNYVYQFFEHDSLLENKEEEELDEDERKQAWFEYQEEKQSQLLKANQKKRVPEKISEQSTTSAENLLPPAAIADPTVDDIILPLPNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVH9</accession>
    <name>A0A232EVH9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_001009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001997">
        <property type="protein sequence ID" value="OXU22350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVH9"/>
    <dbReference type="STRING" id="543379.A0A232EVH9"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000010">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="562" mass="61883" checksum="D6942828FC9A6F7F" modified="2017-10-25" version="1">MSYGYQGPPVAPFPGQKPPTSFGLPPGTPSAPPSAPPYSQPPTSFGMPQPFSPYPTSFQSQPQPPQSSPYPNMGGQSMPLPQSSMPYPGQSFPPSHPGYGHMPTPQQQTYPPQQPPQHQPYPMQPQQPYPSHPMSQPQQPYPSQPQRQSYPSQPPHQQPYPSHPMSQPQQPYPSQQPHNPSYNSGSGLYPNLSGLERPDPTVPPMQNSGSSPYQGGGYSRGQGNRGSFSYGGSAPYSAAAPRKTPAQAKLSPTVVATPDFDPRADAEILRKAMKGFGTDEKALIQVLANRTNLQRQEIEIQFKTLYGKELVKDLKSETSGNFEKLLVAMMRPLPQYYAKELHDAMSGIGTDECVLIEVLCTMSNHEIRVIKQAYEAMYGTPLEEELRSDTSGNFERLMVSLCCANRDESFEVDPAAAANDARELLQAGELRFGTDESVFNAILVSRNAAQLRQIFAEYQNITGHDIEQAIENEFSGDVKKGLLAIVKCVKNRAGFFAEQLYKSMKGAGTNDRRLIRLVVTRSEIDMGEIKQVFQQMYGESLEDCISGDCSGHYKKCLLALIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVW8</accession>
    <name>A0A232EVW8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001940">
        <property type="protein sequence ID" value="OXU22500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVW8"/>
    <dbReference type="OrthoDB" id="7701337at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="42004" checksum="25A22E9C07044D09" modified="2017-10-25" version="1">MLSERERKDNMNVIAIKGLAFDENKETINATVLKFFRDRLNVEVLIGSNNIRTKGKVIVIKLNSAEDKETIMRNKSKLAGTKIFIEHFRSYEGRKKQEEIAAWVKEKREKGLAFKIEKDKLLVRLEVEERKNKEEENLRLAAENREINKRVEINEAIKGLAHYENKETVNATVLTFFRDGLNVEVLIGSNNIRTKGKVIVIKLNSAEDKETIMRNKSKLAGTKSFIEHFRSDEDRKMQEEIAAWVKEKRERVYKNAWNKWEEKDKLLERLEEWNQEERIEDKVDRDNVRKFIFWNVAGVFNKDRNFWSYIEQGDFISLTETWIEEKYIEKFEKKLSNEFEWSLIPAKKDHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW17</accession>
    <name>A0A232EW17_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001924">
        <property type="protein sequence ID" value="OXU22550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW17"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="123" mass="14777" checksum="21103F19529FFBD5" modified="2017-10-25" version="1">MYRHDGCLPFTTFNSTRTYYKKKNKNKKNHCVRVQETEVNVTITRLKTKITFLDNIDRSSRLIVLAKVIYFIILHDRSYLRRRLIYLLETSCLDQSEQAVIVKVELLYRHHMVKLHNYICKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW90</accession>
    <name>A0A232EW90_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL24m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L24, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_012528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001909">
        <property type="protein sequence ID" value="OXU22591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW90"/>
    <dbReference type="STRING" id="543379.A0A232EW90"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_uL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057264">
        <property type="entry name" value="Ribosomal_uL24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="249" mass="29755" checksum="3BD0080DDA1ACCCC" modified="2017-10-25" version="1">MRFDILKLIGEHSKRYANLPDRFIKRKMERIFWKTPGWPKYLPKTHQKKRFRFGLYRPWTNEFRMDNPAHTLPKYEHVQPLRDWSFFRGDRVEIMTGPDKGKQGIVKVIYQEKNWVIVEGLNTVLEMMGKEKGFPGVPIRKEMPLLVTEDVLHVDPLDLKPAKIEWRYTEEGEKVRVSMRTGRIIPIPPSHYETIDYKTPAAYIEGDKDTNKVLVEEVTFKPLLKTFEMDLMDKLNIKEDRVQKPTYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EWJ0</accession>
    <name>A0A232EWJ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001856">
        <property type="protein sequence ID" value="OXU22706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EWJ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7409" checksum="59C6F318E2D981F2" modified="2017-10-25" version="1">MPLNNDYFSTNLKGVENSVTRHFLDVGTYFCMVLNMFNKRKKVAGVCPNICFFGFSNQKMVFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX37</accession>
    <name>A0A232EX37_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_006658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001781">
        <property type="protein sequence ID" value="OXU22931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX37"/>
    <dbReference type="STRING" id="543379.A0A232EX37"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="8">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="89" mass="10812" checksum="5267259C9BFB9498" modified="2017-10-25" version="1">MDDGERMPKINVEKESHKLTNIQKEYMQRIHHQNLTRVQKWNQIRRRNRFLGATLSVFVVSIYSYTMWAIKQESFLDDFNEPEKLKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX59</accession>
    <name>A0A232EX59_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001794">
        <property type="protein sequence ID" value="OXU22900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EX59"/>
    <dbReference type="OrthoDB" id="6287635at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1874"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1961"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1780"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1806"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1827"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1877"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2048" mass="224845" checksum="72520C29D55081FD" modified="2017-10-25" version="1">MDSLLPSEIARLVLGECKLFVGGGYLQEQKCEGAAKTFLETSPLLQECHLVAQRGGKYSTKVGGLNLMDILEKYCAVNAMVQEKLSRVTDNETLRHCNDLLDQLRYLLDGSSSSRGHRFVVNISVPSQSSPSGPLRSPIISGSNRKRHHSGSERGKRISKTLSNMMDKNAQNAVTQSCDTVEATPLESLPGHKASTKQTDLENQINTNDKYLNKIDPMMPAPKIPRFDVPSSSTTNTQPVEPSLGLSSNINVHSNYKDQGTEAIPIIEPLQPVQTLSKCTSGTNTDELMNYCTAEVQTGPCDIIESESDVNDEPIENLSMLTKKLLQRTELHERIAENINKAIMPVETPLREDNVCEHPTEANLSLLNDFDTTIKSIVQATETDPVFEDFLNEIFKVGETDTSPDEDSDGKNNKISNNENYPQNTEMIGTDHNCEVMEPIKLNEQKTDGSEVPLKQRLRSSSRSQNTNIDEEDKDTNILLENQNAEAIMSIVNVVTSKRNSLASSEEFNGEFISIDPVPEIPVVHEPPPEAIVEPEVKKSEDKIKPSKSTTKKTKKPKPPKPIPEPPEVVPTLILCSEKDVESLMHQSQSYIPIAPKPDEATPPIAESAPKIYLRTVNVPRHLINPTAIELSKAANPQILQMLQQQQVGSPQKAVGDAGPIVSSATSDQIVVPIVLTDEKHRAKDGDSTTATSAVPARCVPRSSESITLYGGAGDATEMKVSPISSMPIISLDDSTIGLTAGTGLSPYFKDHIIGGDSIEADSTKKDEEMEAEQVEVQDSAKESEYPKITANTTADTEDDCPEPVVLHVEPDEEELAANALEEKPEEKQGSVKSDNVITTEIIAKRTPRTLLRSRAKNNRLSLSTPRRRNSHVRALDFNTPMKHGTARKVPQSCTRSKSVCRAGLFKSPPFTGATPNVNINLLPEPQPIVKKIRTIAPMNPIIYPQVPIATRSPAPKLQGNWAKYTGIGMILGETSTSESSPEKTPQQETAAKIPSPIPELPEESIEEVPEKKAQDLCVNNVEKPISEKKSWDSDLRRIVGSQVIEAESKSRTRKFRGASIKKKGSASKATKSDAPGDGDAKDKTQDQKTTMDDKKTEPDSKNAKNTDDDNANQPIDKINTSVEVGTETAHKTEITPPSALPVSKKPHFEALSVSKLNVENDKNVKNSTIPKNSPVNVTITRFPDMLDLETPRKTEVTIYVPPTPRLLVTPGDGLKINKSKVDLKIKDCVDTPDFPKTPCIVVTPKIVEEEDNDKKPSPYYEPEDEQPAKFKEIVTEKVVMQVQETKTVTIQKNVIELQENKSIEITEYGVIEESMNQKDQDEQTRSEDNSKEIIEETSIEEANVSANSSANSYSDSDDDSSDSDSSSSSSSSNSSTSSTSSNSSGESSPTKSFIREATEVASQVSPESPPTKSVIQEATETVAQVDPASSPIKSIIQEPAETAIQSSPELSPNKSINQETTDVTSQSFRKDFSMTESEKSSPEPLMQSFSNIGQEELDRLEAISRENSPTKVFSVTKEPSDDEVKETPAKQENMVEAVIGDTPSVTDAERALRRDSLTNLTSKISAIITTSQSDRSLATSSAATSEESCVTSTGKSGLKIKSIENVEPNDLTKKVSEMLHLEIQKNQRLAISQRKAVVNNIVIDAKLSQQLEEKRLRMLAKLNGQKNPKVTGKGKKLIATKKSAETEKFVSSTTDNRKDKTKQQIESDKLVYNSAKNVEKSKSDNVKLADKKTEMAKESRKGKSKASPKKKTAQNDQLSKTEGAKNEANLKKAEKGAMKSTAKETSVTATTITITAENVKKISKSKVDQVKRDLFSDEEINDQRTTRSQTARRTTSGGPKNSNADDGHDANAPFNNSKEELPGVLECLQLIPANKSDQESGNHDLRNETFDNCGPSNSQSNVQDISIVYDESVPIKKRKRQYSTGDLETTYSFTFPEEGITQILTLTECSELFKMTPKYGKPKATTSPKKSPTKVKKSSIKILEKPPMPTAASNARVGKLDERKKKVCKRKTTPIKEDRVVDKKTKVDPQALFKKIKVDEFLKLVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYW3</accession>
    <name>A0A232EYW3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_009232</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01001556">
        <property type="protein sequence ID" value="OXU23614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EYW3"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF217">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="13">
        <location>
            <begin position="209"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="578"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1076"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1110"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1272"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1412"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1680"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1726"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="714"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="833"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="850"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="887"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1128"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1158"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1197"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1412"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1433"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1459"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1487"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1509"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1683"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1729"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1754"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1778"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1792"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU23614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1928" mass="211718" checksum="ECB0166396C16B62" modified="2017-10-25" version="1">MTPSNLVKTAVNSKRHEQERRRLRGIDGASLVKCAATDARRRQQQQDQQPQQQESTRRRPEGNNRHHPEMAGGTSTNAAVPATAASASSTTTSTTTTTTTTSTTSSTSSTVPKTNPSQLKSAPRACTSATTTTNTTTNTTTPRATPCSNRKEELVLPQTLPPGVTQKDVELFKDTRDRANRLTLQQSASETRDEQDENLQPVMVSPGGTGTRNPAAIVFGRYEVETWYSSPFPQEYARLPKLFFCEFCLKYTKSRAVLDRHMDKCQWRHPPATEIYRCNGLSVFEIDGNVNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYAVTKNDKYGCHLIGYFSKEKHCPAQRYNVSCIMTLPQYQRQGFGRFLIEFSYLLSKVEGIPGTPEKPLSDLGRVSYHSFWKSVVLEYLDSHREAKELKIAEITKETGVSGHDIATAMQLLGFLRHVPNGPNDSGKHLAVLVDWRKVDAHMAKVRKSTRIQLDPDCLRWIPLLTQLPNAYQSPEEGDTSSEFASPALDQPPPCANKPVAAMPEKIQRVKIRKKIRGRKIGGAHRRISPIKHKTSPPQRAKLLKEKELKVGDKSSGHVADTEEDIKDETLNESKNIVTTPKTTRTGTATTPRSALNSIGSPKTPTTSNSNSNITTSTPAAPLLSSRRSVRTAMKTPSAANAATTTPAAETLTAVPATPPLRKRKHSEVTESEEKDEIVNSKKRTRESWRDKEKEKEKEKEVKKKDTKTATKEKETKEKPKSVERDSRVKESARLKEREAAAAAKQESPSSRTHRTPPKESATLNTNSPVKAKKQSKLDDILMKVSNQKSKFTPTRQAREKRASAVQNANTEEPQQNHRGSKKEAAADAVKESPSTRRGRPKVDKSAKDSTTVSAESSKSADEFVDEPKEAKASKKQLTIPDMFSSATSNTTASTTASNASQEDVVDSSNKTNSIEENLTMAAISATTENEAPSASPGEYEGGDEDDGDEEDFVPRSKMTSVIQSLDAAIENSEKNGELDEKETAVGPSEENGTSCNNTEMAEPEAPEDNAMEMEEPVNSLEKSEEALPASDQMSIDKSMGEEILANSTSCNEENIGDNMEKESMSVDKSQHLMDDCMSESRVVEPTHSPMETKMESMPSIPSDNRDQQQQQHYAPPVSHPSVIETAESQLQQQQQQLHQPVIMPQEKVLPVVTEQQHHHHETTQVHSQPEEKLHSPEESGKTTPHPENPGSVKRTPPSQPDLPSMGVYTPDSTTNSVHSLHYGQCDLDVSQLGLESPTSIASDLASQNSVERPPSALPTMPSQQSTVSVTSITGGPIQMSAAAAAQQQQQQHQQQQQQQQQQQQQQQQAAAHPVNLQAQQVQQQQQQQQQYADCSMPQHVAIQQHQQHQMQHADKNPYVSNLFIRDQIFSGMKGKIIDGYNFPMQHQQQPHTPQPLQQPRTPQSHTPQSLPTHSPQPMPQQSHTPQPLSQPHTPQPIQTHTPQPMPAQCHTPQPLTPQPQLSIAQQQQQQQTNHRNSLVHAHNQQQAQQQAQQQAQQQAQQAAHQQQQAHSHSSKRTSGSQSSHRSRSAQQGSSSSSRSHRNTPPASQTQSSSQHATLAAVSHNSHLPPQYQQTMAMSVPGMSHPHSHPSHTAHSHNMAVISQGGNYMAVSQAMAFPAQNTYVIQHRGSRSGSHTPCTTATNFYIQTAPMPHSHTPTPATLSTAPGPASGGGNTTTNHQTPNSCSLAKLQQLTNGLEMTPPTPPQAMNLTPPPPIPHTMTPPQPSRQLSTPPQVPLSYTKNYYNAVNAVPPPPGTPGPPPPSRSTSRSSASASMTPIPQSYTSESLYRQTLDPSGSCPQMQSAASRVSPNVAINTNLMAAQAAYGYRVAQPTTGYMNQAAAQLGGFMNQASQLPVGVVNVAAPYAQDPHQQNPTAVYTTHYGYINSGLMQPLNGTMRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ50</accession>
    <name>A0A232EZ50_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Glutathione synthetase</fullName>
            <shortName evidence="15">GSH-S</shortName>
            <ecNumber evidence="4 15">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_006175</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:72075"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:189406"/>
            <dbReference type="ChEBI" id="CHEBI:189750"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:72076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4 15"/>
    <dbReference type="EMBL" id="NNAY01001569">
        <property type="protein sequence ID" value="OXU23570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ50"/>
    <dbReference type="STRING" id="543379.A0A232EZ50"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="18">
        <location>
            <begin position="205"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="401"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU23570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="479" mass="53675" checksum="67B9B80CD6D788A4" modified="2017-10-25" version="1">MTSSVIQPSVDINLPESELKALVSKAKDWMIMNGASMRSKNNFSLDQVQVAPFLLLPSMYPKKEFEVVKEVQPLLNELMHKVAHDYEFLRDTLKSTIEVDSFTSKLFNIYDIVHSEGFAQNISLGLIRSDYMLHSDEGNKVKQVEINMIASSFAALAVETTKYHKFVLTELGHTDKLSNIPANNAAVGFATGLAAGWQVYNNKKAVILVVVEEITYNFSDQRKIEFKIQEISPDTKIIRRTLTELHTQAQLGPNKELFVGEFEIAVVYYRSGYELEAYPSEKEWEVRLLLERSRAIKCPSIQYHLAGTKKVQQQLAVPGVLERFYLESNQAARIREVFVGLYSLDLNEDGEKAVAMAIKDPAKYVLKPQREGGGNNVYGEEIKARLEAMGNSKERTAWILMDRIHPPLQKNYLIRAGSESVSLQDFVSELGIYGIILADKNHILMNNQAGHVLRTKPSLADEGGIVSGAGALDCPFLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ60</accession>
    <name>A0A232EZ60_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_014595</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001521">
        <property type="protein sequence ID" value="OXU23704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ60"/>
    <dbReference type="STRING" id="543379.A0A232EZ60"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="287"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU23704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="364" mass="39689" checksum="FB429355AEFE38DF" modified="2017-10-25" version="1">MREALAVRLELKESRVAVWFQNRRAKWRKKEHTKKGPGRPAHNAHPQSCSGEPIPPEELRRKERERRHKKLMKALERQQRKLAAKGITVDLSTLRAEWESRSAAASGGNSSLNGGFNLNNNHDGTSISGSGNDVNEEIDVVGGLDSCSESGSERVDSAADGSIDGESYPRVLSSSSDNNNPSEQRRNPVVVNHHQIQSQLSGPNASLHLNHQQGIHHWGLSLLERRRELVGLSTAAASNGSVRQTSIETSTTTTATTRSSSLDDEVQSSSIDLSVKGREERRRLNPFSIDSLLGNNNNNNNSNNNNRSGTPDSNQQQHGLHLHRHQQDAKDSIPSAIVAGRDFKSSAASPVSSANSLPTSPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZF6</accession>
    <name>A0A232EZF6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_003927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001541">
        <property type="protein sequence ID" value="OXU23640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZF6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU23640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="110" mass="12071" checksum="8514BDCD64E4DA23" modified="2017-10-25" version="1">MVHFSDTLPLLVDATGKLFDSKLAAMAQPARHAKAGGGNRKSAPQQGRSGSRKERGKSPSPKRKSQRSGENSGQLDQREQKWLIECFKCRGKGHIARECPLGKGNDKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZP3</accession>
    <name>A0A232EZP3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001515">
        <property type="protein sequence ID" value="OXU23740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZP3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU23740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="104" mass="11716" checksum="57246463BF029687" modified="2017-10-25" version="1">MFEELSVNFVLATSRITAMYNAIWDKKLSKYFLGDNSEDFGFSACDTLPSRTVKLVHFLPGCTRCIKNIAIMGLCISLALLITYPIGMLLIQLYCESYKTSQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F043</accession>
    <name>A0A232F043_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_010562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001413">
        <property type="protein sequence ID" value="OXU24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F043"/>
    <dbReference type="STRING" id="543379.A0A232F043"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="511"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="830" mass="95002" checksum="0AC2C512A2307460" modified="2017-10-25" version="1" fragment="single">HRFLRIFVTFFYLRKFEIYPLNFQLETSSDNLVIAAPYGGSIAITRNPKKCVKVQGSAKTIISFYSSSGNLMAKMQWSSGQLVALGWSHQEELLCIQEDGMVLIYDMFGNYQHTFSMGEEAKETKVVEAQFFPSLNGTGVAILTSANRIFLVNNVSEPKVRKFSDVPKFGGVIHSWCVVRQERDSQVVIANHDGIHLLHHSYQTPISIPFHKLFNNKVNGVSAMAVSANSRHIALYSDTGHLYLGSVDFKEKYYEYDTNMKDPLTDMAWCGSEAVVCCWDRTMMIIGCLKGGETISFSYDGPVHLVTEIDCVRVLSAFSHEIIQKVPNVVQKIFRINSTDAASYLLEASKQFQKKSHKADSYIDLVKDKLDSAVTDCINAASHEFDFQTQKLLIRAAKFGKGFSRNINPDYYVNMCKTLRVLNAIRHPKIGIPLTHIQLNMLTHQVMLDRLVARRYYYLGIQIARHLQLSEIDGESRILAHWACYKVKQTSLDKEQIAEEIADKLGYTPGVSYSDIAVRAADCGRKQLAIKLIDYEPKAQLQVPLLLKLGEEQAALKKAVESGNTDLVYTVILHLREHMPLSDFQMAIMHCPLAMTLYIKYCQNHNRETLRDIYNQYDDYYSQALWFVRESYQNSTSRDAMLQSALDNFKLARCDTNASLTDEQIKLLRYQRSLEETLHESVVGKPLHDTVKILLLNNEIKLADKLRSEYKFPDRRYWWLRIQCLAEEGLWAELEKFSKSKKSPIGYEPFIDECLKYKKETEAKKYLTRVKDELKVKYFVKLDMLLEAAQTALEQKDLAAMSYVLSRCNASDRRLQEKVSAMMASLKNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F073</accession>
    <name>A0A232F073_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_010024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001423">
        <property type="protein sequence ID" value="OXU24025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F073"/>
    <dbReference type="STRING" id="543379.A0A232F073"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="280"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU24025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="418" mass="46149" checksum="44C943E8A1D1E51F" modified="2017-10-25" version="1">MKAVILIGGPSKGTRFRPLSLDIPKPLFPIAGLPMIQHHVEACKKVACVSEVLIIGSYNAADIQPFADEMSRNNGLVIRYLQEFTPLGTAGAMYHFRDQIRVGGEDSFFVFNGDVCADFPLEELLQFHKSKKCLMTIMATEATREQSLNYGCLVLNNEGCVAHYVEKPSTFVSTLISCGVYVASNDIFQTMSDVFYSNQPQEKQTITNGYGKDSAYISLEQHIMAKLIKSEKLFALPVKNWWSQVKTAGSAIYVNRHYLALYRQHKPERLASASNSKCQIIDDVYIDPSASIHPTAVLGPNVSIGANVTIGAGVRIRETIVMENSTIQAHSIVLYSIVGKDSLVGEWARVEGTPCDPNPDKPFAKMENQPLFNIYGQLNPSATILGSSVSLASEKILLNSIILPHKELTRDFKNEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0R0</accession>
    <name>A0A232F0R0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001356">
        <property type="protein sequence ID" value="OXU24254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0R0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="7879" checksum="EF5E5E53BD11C62F" modified="2017-10-25" version="1">MHRYSYEIEAVAKNGKADGEELEDWTRWVGLLAPPGSTSRRCCWCLRCCASRERDCGELCKQDGAGRPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0Y3</accession>
    <name>A0A232F0Y3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001327">
        <property type="protein sequence ID" value="OXU24351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0Y3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="105" mass="11940" checksum="7352F1A518B18E26" modified="2017-10-25" version="1">MGEKRYQRSSEIRGEPEQLVPSSKELLQARGLPNTRGDIKLERSSRGKRENHSCGMASLWGNNRGLVSCRCKLLTSLQPPASLHLARWRKRYSNRFTTIGSLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1P1</accession>
    <name>A0A232F1P1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001328">
        <property type="protein sequence ID" value="OXU24348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1P1"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU24348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="659" mass="74837" checksum="687196AB022F54F3" modified="2017-10-25" version="1">MAANETYETSRLVPDHSLSEGPLKRSRQCTNQFWLFTFSIFAIIWISIAIHTISTGNIEKLIVPTDSEGRKCGIDLDVQDKPYLVFFDLTKCVNNRCDTTQVCQTKCPDSNFVYQSSSNDTVLPADVKNKLICQIDVNVDLIKDWSTLDYYVARGKCAKWYLKSKPIIKRCIPETPIPIEFNSTITNDQLNNATSIVLQLANFEKNLENIYHDVIATGYPILGFIGLSAVSAFLYIILLRWLAKPFVYATIIIICAFLVYLIYESSVQYSIQESSEWLYVLVLCIILLIVVVLSTIFLRKKITLACQLIKEASKAVACIWSSLFFPFVTWILHVIVVVATASVLLYLWTMTNPNYQVHVQEMVPNTCICPPTLNYTNNATCDPEIFKSECRDANGGQCVSAGCYLTSVTIPDRIYLYHTINFIAFLWLSFFVSAFEQMSLAAAFAAWYWTFNKHNVPTFTLVKSTWISLRYHIGTLAFGSLIMWISDIIRIVTKPFTSDSNVLPNQPLLCLRAFADVIMSFLQYVNRNAYIMCAIHGKNFCSSARNAFKLITRNIVRVVVITNVTDWLLRIANYFIVVITVGLTLGYYSNKEPGTINDLKVPVVLAFLGSYLITSVFFKVHRAAVDTLFICFLEDSECNDGSVEKPFYMSMRLKQLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1Z8</accession>
    <name>A0A232F1Z8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001203">
        <property type="protein sequence ID" value="OXU24755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1Z8"/>
    <dbReference type="STRING" id="543379.A0A232F1Z8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU24755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="205" mass="22583" checksum="9C3C8BF6905286B7" modified="2017-10-25" version="1">MYHVMISRGGPSIPGGGPPETAILEGAPECICDGPPIPRTGPCNPAGIPEILAGIPRPVARPTPGPVFVPGIGTLGKPSSGGGGPSTYKFRCIKRLNKNFRMWFRSNDAEDNHDKDYLNDMIYIRRYIVDKEVMHLAPVHCLQEFKVTIFSLDDVSSTPGSSWHLDIVYGSQEYFSRMNVDNNNNTANIITISMNEPKIIYHVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F319</accession>
    <name>A0A232F319_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_008648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001177">
        <property type="protein sequence ID" value="OXU24853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F319"/>
    <dbReference type="STRING" id="543379.A0A232F319"/>
    <dbReference type="OrthoDB" id="6070751at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14103">
        <property type="entry name" value="STKc_MLCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000175">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="65"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="202"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="857"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU24853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="896" mass="100720" checksum="29AEC8357CCD832B" modified="2017-10-25" version="1" fragment="single">GRELAADERTHIDSAEGVSRLRLDGITADQAGKYAVSVENALGSDCRFASVAVEGPPEPPCDPPTVKPLRRDTGASSNGVSVTWCSPAYDGGCALTGYTVECRRIGELCWRVVAENCLSLCHEAHNLHAGATYLFRVRALNVHGPGEPSPESRPFKVPFVDMDDAEDKLKVEEDQANMEDENGEYDDKEVTAEEGHLFKERYALHEELGKGRYGVVRRVVEKKSEKSFAAKIVRTVKTSDRKQVREEMKIMNLLRHPKLLRLTAAFESPKEIVMVTEYISGGELFERVVADDFTLTEKDSILFMRQICEGVRYMHKNNVVHLDLKPENVMCHTRTSHRIKLIDFGLAQILSPSQPVRVLFGTPEFIPPEIINYEPIGTESDMWSVGVICYVLLTGLSPFMGDNDAETFANIVRADYDFEDEAFDAISPDAKDFISNLLQKKKELRMSAIQCLSHSWLAQHTENMSRVALPTDKLKKFIVRRKWQKTGNALRALGRMAMLSANRRSPSLSPTSTRSLSEVARSESLDSENLDDSVRREEDESLEHSVSEDEIAKKSEQTGEMDSSKVEEESSKELNVDDVVKTEKDLNMSSKEQASEDIEKDVCEVKQEYSGDKDIEASSKSNEREYDVNLCNEDDDVTEETEKVLDVQESTDDQRKKEDSDEVSESKKTAEEESDEITVIEKEEDTAEKESLEGEESVKEGSDKSIKDNKADEVFKIIDNDSFKIEEDTTQNFCSKLKKSCDVINNESSSKTIENSVFSRGISKSHLEEPRNNGSATEVKRLNNKETGVGADFKANKDIAFDRELTRRSFRKFNTQLEANTDEDTRLDGSPSRGRFVPTGNVSRTAKLFEKLETEQTVHHHHGNNNGLATTAKDATASGKPQRSERIQRAFAFWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F385</accession>
    <name>A0A232F385_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Eukaryotic translation initiation factor 4 gamma 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_013212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD. Interacts with DAZAP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001086">
        <property type="protein sequence ID" value="OXU25191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F385"/>
    <dbReference type="STRING" id="543379.A0A232F385"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MI" evidence="16">
        <location>
            <begin position="608"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="W2" evidence="15">
        <location>
            <begin position="785"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="345"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="435"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU25191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="975" mass="110101" checksum="5D8E2A20C4696C6A" modified="2017-10-25" version="1" fragment="single">AATCFPSPSINNPISYCPIRTLPPPSPAQHHKHTIFATWRVLNHPKLKDSMPSRDDNRSLSTEQRWIPPSTIRRDALTPESRNDVIFRKVRGILNKLTPEKFAKLSNDLLNLELHSDVILKGVIFLIFEKALDEPKYSSMYAQLCKRLSEEAANYENSQKHQQQQQHGGVGLHSTGRTGLNNHLEPGKRCTDSTFTRLLLNKCRFEFENRSKANEAFERQDGELSAEDEERRQTAKRKMLGNIKFIGELGKLEIVSNSILHKCIQQLLDKRRGGSRGDPAEDIECLCQIMRTCGRILDTDKGARLMEQYFNRMNSLAKSPELPLRIRFMLRDVIELRRDRWVPRKATSTEGPMPINQIRNDNDEHSRPGGPLGGGPGGPGGPGSYGYGRNRGGPGDEPGARGMSRDLFHRMDRVSLDNFGIIPLSSPGFAMSSPFSPNGFGPGPNSTPGYNARHNQRNQPAPFYPNQNRHQNNFQAKHNQQQHNSPQNYNNNGNKDGNMRFNKSKMLIGPPEELSLRPSANSMTFKQPNINPSLPMNNGGIDLFPGRIPESPLMRPNAAALAAAATLRKPSPPLLPTKETPAIVIKQGPLDKREKARERKDKGPTKEEVMKKVNALMDEFVGHSNIPDAITAFKDLKMPERMLRWAVYSIYSNSLERNDAERNLAADLICQMRKDSVINSAQHHDGWKELVNSMAEKESAVPCIASHIAQLTARAIVDNLMQLSDLASVTENGQHYPLFLLTLQQLHKSQGKATLTQIFNESKLNLISQLPEAEKTKERLGEILEDRDLTFLYPLLRIQGDMWRQLESDPAPNSLYKWIKEKLDPSHHSDPGFINALITVLLKYITQETTFPPGTSPTVLPEKSLIEKEQALLEKYQRMLQTLLPTIESQVTAVHSLQVFCLSLNFPKGMLLRWFIALYDLSIIDEDAFMRWKEDVNDAYPGKGDALFQVNAWLTWLAEQPSEDEDDEEEEKGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3D1</accession>
    <name>A0A232F3D1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001146">
        <property type="protein sequence ID" value="OXU24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3D1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="78" mass="8674" checksum="8E65A09DB6EAC2C9" modified="2017-10-25" version="1">MRAVKLHASPIECVQEKLKMKYAYDPNNTYFPKTAIENGRINAPPQFSYTNAPEPTGPISIIKQTPGQSRITTNKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F451</accession>
    <name>A0A232F451_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001059">
        <property type="protein sequence ID" value="OXU25309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F451"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="309" mass="35532" checksum="8972641954D3D00B" modified="2017-10-25" version="1">MTITSPSAKNRIRSQKPVIYTKEYLDCSVRKLVAKLDLLKVLFNNLEVSFLSESPSEIDLDSADVVAISRKRLHLVIDFTEKLREHKAHCSMEICRAMDNVYRMLSSIKEQISQLDARVANVIIEIESIIEYANVHIRNIVLTINEKKVEDSLTQSFTNSQINSSSKSNMVDTVSDIECQIIYDSGAINRNPNLKLEKSINIEEDYNHATRNEEQENEFHNDVDYGKSPNKSVDDTCDVLDKTLGDYPQSDISSCEDEYEMDSDISEPEILEKGPNGEFPRPRIWNIRKVFKKYKVRLACIKRDIKDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F475</accession>
    <name>A0A232F475_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000993">
        <property type="protein sequence ID" value="OXU25574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F475"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="47" mass="5247" checksum="05BD7C5505C7CA81" modified="2017-10-25" version="1">MDKIFFQPYLLSIPLCTNMNASAPLSCSNRLSTLTLAFAIETATNWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4P0</accession>
    <name>A0A232F4P0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000956">
        <property type="protein sequence ID" value="OXU25741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F4P0"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU25741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14771" checksum="9B01679AF4D85D28" modified="2017-10-25" version="1" fragment="single">GYKDCFISTTLTNTLEKNDRPPKTLKLIHHCLKNSMKNAFVLTNVKNNDSFLSNYLTNSQAPSETMEKNSHLCRKDVFFNKVKQLHGYNLKTLVNSDRIMNRYDKTKVGYQRFDGIEYYVHSFTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5D5</accession>
    <name>A0A232F5D5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_011249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000999">
        <property type="protein sequence ID" value="OXU25547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5D5"/>
    <dbReference type="STRING" id="543379.A0A232F5D5"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU25547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="241" mass="27086" checksum="8BF4F8B732C4C18D" modified="2017-10-25" version="1">MVYELPESELIAQGAEARLHKGTYLGKTVLIKERFEKKYRHPDLDTRLTKERIKAEARAIVRAKTAGVGTPALYLVDFNRRSIFMQFIENATMLKTFIEQHITGRDDDTAKILMNNVTSALGQAVAKLHSKNIVHGDLTTSNILLKDAESLANAKAETDVSEQLVVIDFGLARVESTSEDAAVDLYVLERSLSSAHAQVPELFGLIYKSYQKFFKNKSHLKEVISKYEDVKARGRKRTMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5Y0</accession>
    <name>A0A232F5Y0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_010970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000928">
        <property type="protein sequence ID" value="OXU25858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5Y0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="116" mass="12561" checksum="C2748901F838E33C" modified="2017-10-25" version="1">MMWISRASGCSVRMYMCVLYKAAGELHLRRRDVQIDARVTRHNGNTPPPAAAASASSSQCLRLAARARALTTLLLSQLVSSCCCLLLLCSVCVCVLALAYARAGSFLKTLQITRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6C1</accession>
    <name>A0A232F6C1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_009774</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000808">
        <property type="protein sequence ID" value="OXU26406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6C1"/>
    <dbReference type="STRING" id="543379.A0A232F6C1"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007529">
        <property type="term" value="P:establishment of synaptic specificity at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097112">
        <property type="term" value="P:gamma-aminobutyric acid receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072579">
        <property type="term" value="P:glycine receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045515">
        <property type="entry name" value="Glp_gephyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11 13" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280179" description="MoaB/Mog domain-containing protein" evidence="14">
        <location>
            <begin position="31"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="15">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="15">
        <location>
            <begin position="406"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU26406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="643" mass="69285" checksum="BF443DA33EFB53BD" modified="2017-10-25" version="1">MSPITFGILTKIEVRFFIVVIFTLVSDSCSENKNDDRSGPLLERLVTDKESEIGRKLNAEIECSAIIPDDELFIQETLIRWSDDVGVNVILTTGGTGFSSRDVTPEATKQVINKEAPGITHAMFTESLKVTPMASLSRAVSGIRGNTLIINFPGSPKAVKECFNAVANVIPHAVDLILDVKKSIKEAHHDIQHSEVYHSCPHKKSAASLSLDNVAGRLRESPFPMISIEESQKLMKNSVVKEISTVKVNIWDALGRVLAETVFSPCDLPPFRASIKDGYAVIAKDGKGKRTVLGGLEAGHKPGSVKIVSGSCVRINTGAAVPDEATAVVQVEDTKLLEKGADGKEEKVIEILTEPKDGQDIRPIGSDIKKGSIVLKAGTKIGAVELGILAACGCSQIPVTYLPKIGVLSTGNELQDAGEAPKPGHVYDSNKITLIMMLKENGYSAVDLGIATDQEKVMIDAIEKAVEEVDLIITTGSVSMGDRDMLKPILKEIFNATIHFGRVNLKPGKPTTFATCVHNGKTKYFLCLPGNPVSAMVTANLFVFPLLNHLTKNNAKPMVVKAKVTSKYVLDPRPEFARVILEWSDDDVYPKAYSTGNQISSKLLSCKNANALLMLPGKSDSQAVLEEGAVVPAMLLGFNQHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6D3</accession>
    <name>A0A232F6D3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_016090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000895">
        <property type="protein sequence ID" value="OXU26033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F6D3"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="846"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU26033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1307" mass="149186" checksum="1AFC9AB746852F39" modified="2017-10-25" version="1">MSKDTKTILKEARELLKQKEFNTTIKICKKVLKEDKRNYNALVLMGAAMREVKELKSQVPKTLKKATDIQPDNPLAWHGLLAHYEGEPKSIEICAELIPVYNKLLQLEKDTTKFTLYLKNLSESLLTANDDKALSECIATLCKLKAKEETDVEKVKLINETIASVLTQYPKITNELDEILEQILSILIQDENSINRHDYYKRYLKLLYKSEKFDKLISEAAKMYSIFHQDIYPLEWICRAYSEYVITHDSSCKKLDIPMYYETLLDHDSESILGYFAKAVYLYQTRDLINARNILSHLVHVKPKWFHAWLLLGKIDISLYCWEDAETAALHAEKLIPEGDPQNLRHVINLLLLEALIKSSNKLKWMKAESKFEEVGIFNLSDGSVKSSILRAHLYVLLRDKRAKVLINNLKNDQNTKIEGTVLHAMDLLQERHLEEAADVLGSILETSEAWLTLGKIHWEMADYGHSLMAFLKGIRADPNNWECLVYLGRYHQEHSKDYDRSKKCYQKALQINPNSEQAGIGLSLVHRLLKNNEENLKLLTQLTNQGRGPKWALLQLGLQYLDQGNSSEAVAILRNAVKADPIDSNCWECLADAYLARGAHLSAIKSYERALKLNSESIYSMTQLSNIKLLVGEKALAKEDFLKILEKNERNVTALKGLAECCFRLGQDYAKAQLLARARENFQEAVDNATIAIKEKSTFLCNWKLLGDICYNVAALPEKYCYLTVVPELVQSDSKNFNITITLKDILLLASRCYCRALSMSKNSPLLWHDLSRCYFAQLHLDTSIDPNEIANKSLAAAKEAVKIDPSNWFHWNLLGVICMSNEIKNYALAQHSFVMAIETEPNNAVSWTNLGCLYLLLEDLYRANKAFSWAQKIDPAYINCWIGQALIAEQVSQNDAMDLFRHATQLGYHHEAAVGYTHWVIKTIMDSRAKQDPLYTYVIENMHAVTVASDGIQWYTVHYPNDPYALNAYGLLLERQKLYKPATQRFSTALKFIKDNKHKDLLSINLARILVQQERYEEAVKICLSIKEASFASHCQLAISLFKAEHFKESYEAYKTAVEWLADSDSDKAHVLCAMASMAYMSQESTAAKTLLFQAVEIKPPIISGYLALAALGMLDGDKHLTDLVLKDLKTHDNNSEYRNHIVKLMAYSYFIQNDREGASKIFLQYIHCYPDSSELWSDLGKILLTISDDSFYKCVEKALFLSENLSSEHIAKIICMSSLSKLITSSPNKGLRAVLNTVHSYPANVDSWSNLITALLPRWAKISQQHAHWLMVLASRVRNNLSCTRSMEQWLLKNEKQANDIAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6F7</accession>
    <name>A0A232F6F7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000884">
        <property type="protein sequence ID" value="OXU26070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6F7"/>
    <dbReference type="OrthoDB" id="10637330at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU26070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15564" checksum="AD90D206CEF12346" modified="2017-10-25" version="1">MCDFLPSSVHKILADVEFSLSLPILFVIGMCTIHLAVNHSMHIACNVKEIMRKRSEKSRKQRKCVKEGPGMMERIKAFASSFFSKSNKISCPEKPRKCIKSKPACKRSCGDKGDLKFDGDDDWDDEEDDDMVDLMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6W6</accession>
    <name>A0A232F6W6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="13">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-specific succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="13">A-SCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Succinyl-CoA synthetase beta-A chain</fullName>
            <shortName evidence="13">SCS-betaA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_009927</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="11">GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 19">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="13"/>
    <dbReference type="EMBL" id="NNAY01000861">
        <property type="protein sequence ID" value="OXU26169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6W6"/>
    <dbReference type="STRING" id="543379.A0A232F6W6"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03220">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034723">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 13" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="502"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="546"/>
            <end position="548"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="820"/>
            <end position="822"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU26169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="905" mass="97908" checksum="3D5A2A6AEBB0025F" modified="2017-10-25" version="1">MLKTLAKFAVKDGQIKSILAGIQSSSCSKQQRRFLNVHENQAYTLLKSMGIPTPKFGVAKTPEEAAEIARKLDSKDLVLKAQVLAGGRGKGKFIGSNVSGVVMCETPEEAKELASKMLGKYLVTKQTGEAGRICNEVMITTRMFTRKELYLSVMMERSFDGPVIIASSEGGVNIEDIAATNPEAISYTPVDIRKGLTCEQADAIARRFGVGDPRVLSEIVCNLYELFIEKDALLLEINPLVQDICGQYFALDCKCNFDDSASFRQKDLFALQDWSQKNPMEVKADKIGLNYIALDGNIGCMVNGAGLAMATMDIIKLYGGEPANFLDVGGGASVKTVTEAFKIISSDPKVESIFVNIFGGIIRCDVIAEGIIAAFQDLKLNVPVIVRLQGTNAEKGKKLIMDAKLKIIPIDDMSAAAEASVSVADICRLARNLNLDIELTPKSTQKSRATRLDSKMATMLSRTTVSLAESLSRLNGSKILACTSSLNKQPVRNLNVHEHISYSILNEAGIPTPKFGVAKTPDEAAKLATDLNTKDIVLKAQVLAGGRGKGHFKGGNVSGVKMCETPEEAKQLASQMLGKLLVTKQTGEAGRICNAVMVTQRMFPRKEYYLAVMMERAFGGPVIIASSQGGVNIEEVAATNPQAIMYEPIDINKGITKDQADRIAVKLGLENVKEYISKMIMNMYSLFVKKDALLIEVNPLAEDINGEYFALDCKCRFDDNAEFRQKDLFALRDWTQEDPKEVEAAKFELNYIALDGNIGCMVNGAGLAMATMDIIKLHGGEPANFLDVGGGATASAVKEAFKIITSDSKVHALLVNIFGGIMRCDVIAEGIIAATKELDLKIPVVVRLQGTNVDEAKALIANAGLKIVPVDDLDEAARIAVKLSTIVKLAQSANLSVNFEIPQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F7J8</accession>
    <name>A0A232F7J8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 593 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with pre-60S ribosomal particles; released from the pre-60S particle very early in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000803">
        <property type="protein sequence ID" value="OXU26429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F7J8"/>
    <dbReference type="STRING" id="543379.A0A232F7J8"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU26429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="157" mass="18590" checksum="23D93D74AAA6BEDF" modified="2017-10-25" version="1">MVYRRKKHHKENLHIKKAHRTKRRTKDLDELYRVVDCCWVKPTVFCPKIDADLKEENAIKLINQEVDFDKPGAAQNYCIHCARYFVDQKALHDHFKTKVHKRRLKALEEEPYTVEDSERAAGKGNFVQPKKRKIETIASEEDINKEAKVMKVDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9K3</accession>
    <name>A0A232F9K3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000620">
        <property type="protein sequence ID" value="OXU27355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9K3"/>
    <dbReference type="STRING" id="543379.A0A232F9K3"/>
    <dbReference type="OrthoDB" id="7696986at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="58198" checksum="119D9CB43FB66811" modified="2017-10-25" version="1">MDWVNILKTKIQCDLQPYQVVMITNRSHHDLSVEENILHQSIIREIPVKLVDIKQPDADTLFSQPEFRNPRHVVFYLAVMRKTINSNITESTLTIIDLLASLSPVHRQPKCLIIIFSDDSGSDDSFYQILKFAWTKKILDITILQVKNGMILTHIYNPFRQRITQQPFGIQTNIFPDKLKNMMGYPVNMMIWDRPPFLNLVEDKKEKIIKFKAIYYSLTELLSEKLNFTIKYPRRTYERDISTISEMQVSGLSDGTLNMSPIILPLTTFNPNWKIEIGAFLLWSKYVVVVPIISPTHILVPFRILVYTSILAVTLAISIFSIRYFKFERRYWKVNYLLQILLNMTIPKTPRNSYERIFFVCLVWLSMMYFNVLFASLHDVNLIHDGVAYDTFEEIDNSDMSIYVEPTFISQFLATNDGVMQRIRKKAIFLPLIEDCGRKLKDTGKVVCLTSKIRAQKMIRDSTYLGAASMRIAKEVFWYTPLTYSYERQSPFVEKFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9Q7</accession>
    <name>A0A232F9Q7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_000066</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000622">
        <property type="protein sequence ID" value="OXU27342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9Q7"/>
    <dbReference type="STRING" id="543379.A0A232F9Q7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000035">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012172524" description="Cytochrome P450" evidence="15">
        <location>
            <begin position="23"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU27342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="94256" checksum="ABA8F948D6A84E33" modified="2017-10-25" version="1">MIVEFLLLLLLAACIFHYYTRCGRVAKLTENIPGVRAWPIVGSLPGLMKSQDELWPIFRKMSNDYYPTYKFWTTHEVVINIRHPDDIEILLSSVQHLEKSTAYKLLHPWLKTGLLTSAGNKWQARRKILTPAFHFNVLKKYMDIIVENSERMVRSLKTKASDGPIIDLLQFSTNYTLNVICETAMGTSLHGMEEFQEKYRNAIHKMGNVLIYRIARPWFRKESTFKWTQKGQEQTAALKVLHGFSEKIISERKEYHDQTKYNYLNEFMTNDVNDQEDNEIYGIRKKRLAMLDLLIALFRNGQIDDEGIQEEVDTFIFEGHDTAAMGLSFALLLLAEHTDSQSRARDEVNEIFNKSGGKMGYSEIQQLQYLEMCIKESLRLYPSVPFISRQLNKDLQLKHYLIPSGAIMHVHIYDLHRDANFWPEPEKYDPERFSPDTIRNRHPFSYIPFSAGPRNCIGQRFAMMELKASIAHLLHHFILEPIDYAHEVPIRSDLVIRPARPIRIKFVPIKHDALLFAIHYYIRGGRIGHYVNKMPGPPAYPLIGNLLSFMVPFDKLWQVVRKMNDDYYPLYRIWSTNVAVINLYHPDDAEVLLSSTHHIEKSIIYELLHPWFGTGLLTSTGTKWQHRRKILTPAFHFNVLQKYMDIIIENGERFIDTLKAKGESVQNLLPLITNYTLNIICEAAMGTSLQGKEELQAKYRRAIHDMGNILVHRLVRPWLRWSSLFNLTPKGREQKKALKVLHGFSTDIINERKEYHEKTESKFLNNTLASDESSKDNADTEVFGGEFFYQRKYPRIARKNKIIMYVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FBY7</accession>
    <name>A0A232FBY7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000501">
        <property type="protein sequence ID" value="OXU27973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FBY7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013348280" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU27973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="88" mass="9250" checksum="08CE66E93A221866" modified="2017-10-25" version="1">MFKPILIVAFCIAVLAECKPSKDSREHHRVARSPQHMQNAMKLGGQMANEGIQAATKGMNVLSTAAQQAMSAGTQIAADVAKGATSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FC18</accession>
    <name>A0A232FC18_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000461">
        <property type="protein sequence ID" value="OXU28215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FC18"/>
    <dbReference type="OrthoDB" id="7697968at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU28215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="196" mass="22676" checksum="995CD2323CDA4435" modified="2017-10-25" version="1">MFSKVISHFFDRSKKSRKSEFFGGDRDNGKNSMEWQEDDDDDRRSVESLSWIGTNDLEKSKSDSSIIPIGDCNYRARGVQVTLGTCGAQKKLTSALRNLDISNDDDDGDDERNVSFTPVITKDCPYNQLDSNSFRYGFKTQNLTTKELVSVGPEILNFQGNLHSPEEIAMYWKKDCRMWLWKSFRRRNQSRNTMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCH1</accession>
    <name>A0A232FCH1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">P3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_001502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000467">
        <property type="protein sequence ID" value="OXU28173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCH1"/>
    <dbReference type="STRING" id="543379.A0A232FCH1"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013144678" description="P3 protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU28173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="48288" checksum="2EEDCEAC0E032244" modified="2017-10-25" version="1">MILILIGFLLLGTANAAPQITFNRTELEIHMDDVTSVPFTIEGLTSAVSGVNLTAISSDWNLVQVSAPIFDPALIQNGVYKSFLNATGIFLGNAEVSLFLSINGEAVKSDVINIIVIRKVRVVDTLFTASVAILVSILYINFGCAMDWDVCIKTIKRPIGPLIGCLCQFILMPLISYALAIILFPDSPEMQLGIFFTGISPSGGASNIWTILLGGNLNLSVTMTTLCTIAAFGLMPMWIFTLGKHIFERGNLVMPYNKIATFAIGLIVPLGLGYLIQKKLPRVSRILVRIMKPFSVLLIIFIIIFAIVTNSYLFKLFSWKIIIAGMGLPWLGFIFGLIVAFICRQPDQDIRAIAIETGIQNTGVSIFLLRFSLTQPAADLTTVVPVSCAIMTPLPLTILYIIKLVLDRRKTKLAASREKLQNPQTFVAVPAANSSTRLNQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCI6</accession>
    <name>A0A232FCI6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_016155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000420">
        <property type="protein sequence ID" value="OXU28524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCI6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="27" mass="3085" checksum="A33A969330505C38" modified="2017-10-25" version="1">MSDPTLALNDLILKIEMCTKKAEYKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCY9</accession>
    <name>A0A232FCY9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine synthase</fullName>
            <ecNumber evidence="4">2.5.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Putrescine aminopropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_002151</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000447">
        <property type="protein sequence ID" value="OXU28319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCY9"/>
    <dbReference type="STRING" id="543379.A0A232FCY9"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="12">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU28319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="288" mass="32272" checksum="D406DB592057B600" modified="2017-10-25" version="1">MNALKQGWFSEINGLWPGIAQSLEVEKILYEGQSEYQHVLVLQTKSYGKALVLDGIIQCTEKDEFSYQEMISFLPLCSHPNPKTVLIVGGGDGGVAREVAKFPGVEKIYQVEIDNKVVEVSKQFLPFMAKGFSDPKVNLHIGDGFEFMKQHNNEFDVIITDSSDPVGPAISLFQEPYFALLKKALKPNGIVCCQAGTVWSNLDQVQDTLTHCKSIFPKVAYGVSSVPTYPTGQIGYMLGSLNPETNFNEPLKTFSEDELDKMELRYYNDKIHRASFELPRFAKKSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCZ0</accession>
    <name>A0A232FCZ0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FUZ/MON1/HPS1 third Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_012859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000445">
        <property type="protein sequence ID" value="OXU28328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCZ0"/>
    <dbReference type="STRING" id="543379.A0A232FCZ0"/>
    <dbReference type="OrthoDB" id="10255234at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031085">
        <property type="term" value="C:BLOC-3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026053">
        <property type="entry name" value="HPS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761:SF1">
        <property type="entry name" value="BLOC-3 COMPLEX MEMBER HPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12761">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="2">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="3">
        <location>
            <begin position="562"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU28328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="81669" checksum="5A31C29D427C907E" modified="2017-10-25" version="1">MKGIMIFDHLNDVLFTKCNRKFANHIQKLAKLQGLVGENKDENDSQDFKPSPNIIMQLFSPIVTSQHVMASQFGNTYTSMKCQDGTNMVFDEFMGYTFVYVSNEDVELMRRTLGVCVTIIRHLCGPDVSVLKTNKQKVKMVSHLLDAWSDLRGSEQNILTEAVEQLSVNADLASATLRVLSDAADKLKAQSEFSNVHVLILVEHKFLSLYSSKNAQDLLASDILLMILLCYVAKKLRNGEYDVSEKDTKDDYVLMSRTESIKKEEEAKSHGNFGKLSIPTSEDISNLFEGSRDSSVSEGLCYFALDGLYSQLVLLGSEETGYTANAIHISELAEGINLVTIVEMTNLAISSGLYDSFFHLNVINGLQLQRDIDELRPAFDHLETAIKKTLDGIKKNRSHVSNDVDMCQRRLQMKWDFVRKKYLELLKSRDPESILQIESNMVGFVDALKELFRLTCLDQSFLKQGTDVILTVSRLVSQKLNDFSDFLKVKALKNFNIRSYPFDTALYIAIRTSVKVAILKTKYSAFTVVKISIQAISVLNVLFCVSTRTSLTINKYLEEFPGLVHFIYIDRTTHRLTAPTIDFTNSETLALTTKKIWTMVEQSRIHLQEGHMSIMWKDTTFNYAYFLWFEDSSGTPLKCKTIFNHTLKNFPVPGILCGDYYRKLAEAYFPKLSPNKIRIYELYCVHLGLATSSCVLEHSRRLAATIWEVTGLPNNPADIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDC9</accession>
    <name>A0A232FDC9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_005477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. The active form is probably a hexamer composed of 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="NNAY01000378">
        <property type="protein sequence ID" value="OXU28796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDC9"/>
    <dbReference type="STRING" id="543379.A0A232FDC9"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000011">
        <property type="entry name" value="Putative ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU28796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="346" mass="37948" checksum="2DF027C4BA8C0143" modified="2017-10-25" version="1">MITSQLIRAKSLLRASSQRSCIQKLHDKMPNIKVFSGSSHPELVLQICDRLGIEPGRVVTKRFSNLETCVEIGESVRGEDVYIVQSGCGEVNDNLMELMIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLIANMLSVSGADHIITMDLHASQIQAFFDIPVDNLYAEPAVLKWIKENISDWRNSIIVSPDAGGTKRVTSIADRLSVNFALIHKERARANEVCSMVLVGDVKNKIAILVDDMADTCGTICHAADKLLQAGATQVYAILTHGVFSGPAINRINNAAFEAVVVTNSIPQNRHIEDCSKIKVIDISIMLAEAIRRTHNGESISYLFSNVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDY1</accession>
    <name>A0A232FDY1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_006144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000418">
        <property type="protein sequence ID" value="OXU28547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDY1"/>
    <dbReference type="STRING" id="543379.A0A232FDY1"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="130"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU28547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42386" checksum="58F184222B22A701" modified="2017-10-25" version="1">MLPGIGVFGTGSVVRIFIPFLREKGFKIEAIWGRTIAEASEVASDLEIPFYTSRIDDVLLRRDVDLIFIMCSPNLHAQIAVKALGIGKHVVCDKPAGLSQSEALKMVKAAQYYPSLISIVNHSLRFLPAFIKMKREIEEGYLGGPVSIIDVRVQMGSLVRDGYDWLCDETMGGGILALVGSHVIDLISYVTNQRAVRVHAVVRTFTQTTKHINGIRQITSPDFCCFQMELNEGTLVTATLSNHLQGQLSQEVLICGPNGHLVVKSGDLHGCRGQQEEALHLDVENVQESSIADFIPRPYIKGLHKMIDALREAFQPVEDKRGWIKEPVSRAATFEDGLYVQAVIDALKRSSKRREWVKVTIMTEEPDPNPLLSAAVRATAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE16</accession>
    <name>A0A232FE16_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000351">
        <property type="protein sequence ID" value="OXU28991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE16"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU28991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="75" mass="9205" checksum="7B7A91080D9CE4F0" modified="2017-10-25" version="1">MIKQFLRIRVWSIAKIENFEFYPYQIARVRCQMRLLSGSYESQFCFHILGKFLQFRLRLALENDTPEACIRFYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE34</accession>
    <name>A0A232FE34_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000357">
        <property type="protein sequence ID" value="OXU28922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE34"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013076503" evidence="2">
        <location>
            <begin position="18"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="665" mass="75664" checksum="65253D85BDDF5CB7" modified="2017-10-25" version="1">MATKLALLLCLSTVAFAAEDETVWFEPKTWTGPGVLPEELREDVTTIDWDDTTVSRRRNMGSETSELPPTDIPSPSKWKEQTEQVLSVRSMPKQKVQAYDEKASVPLEKHPIRRYGAYPPMEAGPNWLGMLGSFGSDEETRRQAPSVVVNEEKNVDNSKDESQLNRALEVENTEAEEKQSLKALPEEKQAEVDISTWQRPNCVCVRRMTESPIQTSRRDLDGSGTRVVYQRRKSTSIKCSCSSDAMTKMLQTPHDTRKEMGLYNVIKRTIHKTRKNNYDLSGSEYSGELSDADVLEIPEEHEYDDENEYVDSDEEADIYIYRKSEPRRAPAVGSKTMKLDKNAKLGSQKVKNPRADVDAKTYDGSGEGNIYIYHRADNQPQTLRSRTTKRGLQKLKNPRVDADAEADAEIAEDELTDNNDADYDEVYVSPRRRESFTDRTLRRSDVTDQPPIDPRSIPQSKQEAFTDRSLRRSDVTDQPPIDPRSIPQSRREAVTDRSLRRSDVTDQSPTDPRLLQPSRRTEEVLEQEPAIEERSQPPSRRSDDTDAQGQISRQKPAIDLRSEPPSRRTVEIDTPDQRPPIDPRSQPPSRRADGVATAGQTLPIEGRSLPASKQSDKTVMQDELLAYNPRSLRPSRRIVIPEDNNANKTVPRPPFRRRDLRSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE50</accession>
    <name>A0A232FE50_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA non-specific endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_005471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000378">
        <property type="protein sequence ID" value="OXU28790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE50"/>
    <dbReference type="STRING" id="543379.A0A232FE50"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF17">
        <property type="entry name" value="ENDONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="80467" checksum="3508F0C4AE8F2208" modified="2017-10-25" version="1">MNSPIEYGLSSRLSLKKLKTKKSLISSDDLKPNKTKKEATDYPKNNIQKRSIYYEIYPHYHTLDDYLHDHFNSAIDQSEKISINSNTTTNGTEFCAIDIKQLSEKHALIIEYKSDIMKRNYLNVMELFINKNNLSPNYAISTISGMIAGGQDEVKWREFTDINSNGKQAYASQKQENSPFRNQLKCLNSQSNKCTYFSEDKNRKFVPAQLVHPSSFLYKVGGLTTFLYSNTNPQWPSIDKGLRTDLNIYTGTFDKLKLIDHADAYLEKSIFLNPYEKQKIKYSIPIPQYFWKIAYDPVHEQGVVFVTVNNPFIVHGPDYHLCKYSRSEQPNVLMPKGWNPNNITEGYSYICDLSDFLRSTNLNIKGLKNDNGLLYLPSIRHYISADNSNEVSLDQKDDDSEPDTDDYFDSEYCSISIDSLSVNKPLPIKNWTYKEFAHFYYPNYQGDIIITEGSVVTFMCPGDNNFKYPIYDSSRGNVNQYHKFICLEGKFELNGEEYDLNGLTCENNLSFDIEKNDTSIDGSITSYWLRFSYVDQKVNLIQIYYDNTISSTLYVQYPIRRSIRGRQELVKTLNREFDDIGCCSGLNMNDLYSPKRNFTKFSCYENICAEYQILALREGGYFTPAQLAPPTHLHFEAIANVTFTYLNTRPMWKTIFRGNWALLDEEEIMVYSGASGQFEFVSKHLLHLQGVCPQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FE51</accession>
    <name>A0A232FE51_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000342">
        <property type="protein sequence ID" value="OXU29056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FE51"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="63" mass="6979" checksum="750FF8D4CFFC45B9" modified="2017-10-25" version="1">MLTPSTIQITIFCLNQCQVPEANYVDAIGSVKTYAAQYNKGNIPKAIKLKNRIYTVNSTSVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFD5</accession>
    <name>A0A232FFD5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000287">
        <property type="protein sequence ID" value="OXU29476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFD5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="212" mass="24750" checksum="77219A23A818CDE4" modified="2017-10-25" version="1">MQTFKQLQDHGQSRDNQQHSQLRYLLQLSTPVLQSMINSNCIPTEHRVTTKRGQQEQQEHQLRHQLPLMPIAELCRSNDKGKRQKTQKQHQQSGEREREQPCPFSSMDMVEVPKYHNDSENSPREPVQQPNLQDQSRMVKFKKAGKATKKKTAIRKKLVEDQEQWLRQATQRRILQPLLITDILASMPPLPPEKDVTPGIIPILLKKSKECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFP0</accession>
    <name>A0A232FFP0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000336">
        <property type="protein sequence ID" value="OXU29117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFP0"/>
    <dbReference type="STRING" id="543379.A0A232FFP0"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="404" mass="45698" checksum="B34E8A39ED6DD2BC" modified="2017-10-25" version="1">MTTIVEVPRENLTLQDLGRRNTVPIIYTRGTHYDIGFDIGRTFGKLIRDYVERYKPLNETYLSLYETIEGRRVYDETLACVKEQYPQYVREIEGTADGSGVPFYKLFLMHLDDIVPNAAADGAQGNTQPVGCSSILCNHPGQEILGHNEDALTETMNHWYLVDAHVVEPGLQEEKFCSLSYAGFLPGYTMGYNHHGLIYSINTLSARTLRSGKTPRYFITRALLGVENFVKAQETLRNEGYGAAEGFSVNMTFLKQEGDRMFHNAEVGPVETGDTRSQLCIMTASPGENLFHCNKYMRLKVPEVEGLIIDSSIHRMAAINRHPPPKTRQEVIDILSDQTGDDFRVYQDIRPEDFVKTIATGIFDCIARTWSIYTDKPNCNEPIVVLPLRLKDDEPQCCRMKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFW3</accession>
    <name>A0A232FFW3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_000825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="NNAY01000260">
        <property type="protein sequence ID" value="OXU29656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFW3"/>
    <dbReference type="STRING" id="543379.A0A232FFW3"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012963548" description="Adenylosuccinate synthetase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="424"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="449"/>
            <end position="452"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU29656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="773" mass="86231" checksum="B5A244D13C7C4D37" modified="2017-10-25" version="1">MFQRTQILLIFVALCAEAAVSLSKITSTNKDWIFTLNHPRNIISIAPNNGYDNFAYASCDHVGQNLVTEIDCIVTVQYNIFSQAPGIRMCEVEIRSEDGYFIKDDSYALDMLDNDKAMFYLDEVPVSGTERLGDFIQKKPLILKIRTISMSNCGSTGSDIVVRLKRTSWIMPEYYVIPREGKLNVVTRSDQAPCNGSFCILTYDTLGKEIGRPTPVVPNGNSEPGVLISLRTSSGKYFTLFVRSAEKLMKAYYAEPRNDVLRPIAIEEKYPDEELLYDFDFLNGSARFLECYKNSSFIQCKLMNERSNLMTSVAFPAESEKIMKSLLLESGGFLLLTDSDDMEDVHLSKIELDGSRRKIANFERFSCVDTQRLLAGVGKVCLVSTCKRLDATGLGFKYKIKQTMRVFGQNQTKVTVVLGTQWGDEGKGRVIDMLAGEADVVCRCQGGGNAGHNIVVKGVKYRFHLLPSGIINPNCKSVIGSGVVIHLPDLFKEIEENEARGLENWQDRLIISDRAHLVFDFHQQLDQLQELEKGTQSIGTTKKGIGPTYASKIARAGIRVGELVEDYGNFSEKFIALAASCKKIFPALEIDLKEELERYKGYADRIRPYVKETVHYLHQAIKDGKKILVEGAQGALLDIDFGTYPYVTSSNCSIGGVCTGLGLPPSVIGEVVAVVKAYTTRISAGPFPAELLDATADALQNRGCEFGHIIKHKRRCGWLDLFSLKYTANKYVRFIEDYLDIPVKWIGVGADRESGHLKGIIPMMDMLIFVHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGD4</accession>
    <name>A0A232FGD4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000265">
        <property type="protein sequence ID" value="OXU29623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGD4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="72" mass="8031" checksum="F4D7FFE37E857681" modified="2017-10-25" version="1">MSPVPTREKPSVLSPAELDSSPKDQTPVDKWTPRGLIKDTSYFRGREHWDTAGLYYAPDNIGQAEIAATRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FGX4</accession>
    <name>A0A232FGX4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000250">
        <property type="protein sequence ID" value="OXU29708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FGX4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="141" mass="16431" checksum="6719A19DF5228E1D" modified="2017-10-25" version="1">MKTMILLHRVRPKTIIHFHQTRRQASISSAPSPNYLRISDNTSRPIEHSDRQLKNSSQASDKISTYARPSHAHRRRREILEKGLYYTHDVRATSLGGQSAHPVPSLFLSAFLRSNFRSVDRKSRVFDDFLISVLQQQRRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH18</accession>
    <name>A0A232FH18_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000229">
        <property type="protein sequence ID" value="OXU29853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH18"/>
    <dbReference type="OrthoDB" id="7675289at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="226" mass="25820" checksum="F527F2F488A4F4C5" modified="2017-10-25" version="1">MSSGTSTNESKLASRRVSLCIKGELKELNEVKLSIVSTNVMKTRSLGSRNLGGRNEDDYDFYYGRGYSEDPFEDEFVSNQRRFKDRASAAFEEDLADLRRKRRDMQDRMFDMTDLSAEIEKAKVTLGAADTLFQRHALRFDNEADDYDESISLASRIDRNRKIAAQEIPDPKPPVKWTKLVPVEEGCAPPPQLMARRISYGNNPYGDNNEPRGKRGYSKRKKSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FH99</accession>
    <name>A0A232FH99_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000223">
        <property type="protein sequence ID" value="OXU29900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FH99"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU29900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="97" mass="10763" checksum="1FED05FD31A1AE13" modified="2017-10-25" version="1">MELSFQRFDMLPDQLDGLRALVSRGSVPRGISSALAERGATVGTEELNTRISALETQLADNINASNRLLDANKLLLDENSILRDELQQTQQLLGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHD9</accession>
    <name>A0A232FHD9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_002826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000226">
        <property type="protein sequence ID" value="OXU29878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHD9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="137" mass="15480" checksum="52E66CA364CA36D9" modified="2017-10-25" version="1">MSQKNQASELHNDKMEEREKEDQVGRGVGDRRGRGDRWKKIGEKKVEQEKLRKGPRKGSGKESGETSGKDSDRSKGSVVEKDKGMKEGGTLNVKTGVIEQKKGVQDEVMAKKEKSERKIKEEGRRALKEAEDKKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIB6</accession>
    <name>A0A232FIB6_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000185">
        <property type="protein sequence ID" value="OXU30199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIB6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="40" mass="4530" checksum="8AE8333FC0CC621E" modified="2017-10-25" version="1" fragment="single">SVIVRRLAKITVEFSSFKESVRSFLLIRDSPKLPVAHLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIN6</accession>
    <name>A0A232FIN6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine aspartase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_014925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000172">
        <property type="protein sequence ID" value="OXU30328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIN6"/>
    <dbReference type="STRING" id="543379.A0A232FIN6"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000006">
        <property type="entry name" value="Threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38368" checksum="1B47F7E9ACC5B904" modified="2017-10-25" version="1">MNKSSAGFIAVHLGAGQHSTVLKEKYQKLSKEACEKGIESLKQSKNVLDAVVDAVIVLEDSQLTNAGYGSNLTYEGNVECDASIMDGATLHYGGVGAITGVKNPIEVAKLLCQYQTVDIGHGRVPPSFLVGSGALTWAKEMGIKSVPPENLISVKAQKVYKHYKRKVENDTIEIGQQLKRRLDTVGAVCIDQYGNVASACSSGGIILKYPGRVGQAGVWGCGVWASKGSISVGTSTSGCGEHLIKTTLARTIAESIEQTDCPTRSLHDTMHSNFLDSRFLKDLNEKYGGVLAIRYSAEDGCGDFLWSHTTNSMIIGYMNSNDKSAKSRMSILSPPDVGKKAIIEGILFKLQEPNECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FIT6</accession>
    <name>A0A232FIT6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000166">
        <property type="protein sequence ID" value="OXU30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FIT6"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7348" checksum="B1A63E21792153C9" modified="2017-10-25" version="1">MFYHMKVCTLTKAVEGACHGDSGGPLVADGIQVGIVSFGIPYARGKPDVFTRVYTFISWINEKMAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ00</accession>
    <name>A0A232FJ00_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_011974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000159">
        <property type="protein sequence ID" value="OXU30438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ00"/>
    <dbReference type="STRING" id="543379.A0A232FJ00"/>
    <dbReference type="OrthoDB" id="530923at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045363">
        <property type="entry name" value="CERK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF111">
        <property type="entry name" value="CERAMIDE KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19280">
        <property type="entry name" value="CERK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="147"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU30438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="542" mass="60415" checksum="92C3678A11410E9A" modified="2017-10-25" version="1">MQENANEGDPSYHTVLLSTFVIRKKRCRVYFHKGTLIWETERPPYTRWTLPLTDVLTATYGDDVRVSGPTGTSNEAFRDKEKESQASAPTSPSSTTPNSPTSFVLHYAAEGAKNKWSHHSVTMNHDDPRQVSSWVKTIRNYLANLSHRPRKILLFVNPFGGKKKGLHIWEKRVQPLMGIAGVEAKVIVTERAGHIRDVLLNCELDSYQAAVCVGGDGTFAELFNGLIARTARDQRIDLNDPDVLLPKPTLPVGVIPSGSTDTLAYSLHGTTDVETAVIHIVFGDSAGLDVSSVHNEKNLLRIYASIFSYGYLGDVIRDSEKFRWMGPQRYDYSGFKKIIANKGYEGEVVLLSDPGHPAACERCTKNCARCIEISHNDTADDNKLLTVRGKFFMVNGANISCACSKSPMGFSPHCHIGDGCVDVILVRHTSLINNIRMLLRLSSKDKTLYDLPFVEVYRAREFTFKASNPSSNQQQRQQSYENSTTTGPRSNLGSSALSVWNCDGEVIDASSVKIRVHRQLLKVYTRRMQPEPRPNPSCFCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ46</accession>
    <name>A0A232FJ46_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_013227</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mab-21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000123">
        <property type="protein sequence ID" value="OXU30761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ46"/>
    <dbReference type="STRING" id="543379.A0A232FJ46"/>
    <dbReference type="OrthoDB" id="6054650at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF42">
        <property type="entry name" value="CYCLIC GMP-AMP SYNTHASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="12">
        <location>
            <begin position="71"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="13">
        <location>
            <begin position="263"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="13">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU30761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="438" mass="52369" checksum="9FAF35A5931E0658" modified="2017-10-25" version="1">MYETYYDSQHSKYRDDTIFGYVSSEYLTLSEEDRKVNNEHLHAVVQEILELMKQDDLFNLMFREIKYVGSYYKGTKYGTPEEFDLNFIIYLPIDYDDIRIDTNHKNFGFVKIKLDSKATLDPEWQEYSHELDGLLTRDNYLNQKKFRSWVESVFKNTLSCYETYDGYEFFINDKLYHIKYKKSGPAFTLMISTEDEIEIDVDIVPCLEFGHMRLKNGFKPMNKELNKTWMVVAKPLPRDNPESNVLWRPCFYQYEKYILEGAVKPVIRMVKKLRDTRCWNNLASYYIETLFYHELKKHSYNEDVKERYLRSSKTWLFMHVGIFIRIQKIKSIIFFFTTNSTFSQALNQLQKALERQEIPYYWHPKFNLLGKIDEKVLKRYAVELKKIIAFIDSNLESNYMVLADAVCNGKERSASDKEKMKTRFCAKRAETDVRDIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJ52</accession>
    <name>A0A232FJ52_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_009861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000121">
        <property type="protein sequence ID" value="OXU30774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJ52"/>
    <dbReference type="STRING" id="543379.A0A232FJ52"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16475">
        <property type="entry name" value="RING-H2_RNF121-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000074">
        <property type="entry name" value="Ring finger protein 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040176">
        <property type="entry name" value="RNF121/RNF175"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407:SF0">
        <property type="entry name" value="FI05221P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13407">
        <property type="entry name" value="RNF121 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU30774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="327" mass="38600" checksum="59BCEC0F51B2CFC5" modified="2017-10-25" version="1">MDIHVMPNKVIIRRFSNNTAVDSEADLTPEERWRVEHIKMHEQHRGHESMHMEMMLILIVTVIVSEVILITWKQRHYKSYQLITLFGMWIIPLGMCIRNLWWRFIFLWLVFSCITGLIVRKTVQRPMQGTTPRLVYKWFYFIYKLSYFLGIVGYFVMLATFFGLNLVFDVKPQVWMDCGLLFLFYGLYFGVLGRDVAEICADKMAAHIGYYNPGSMPTRTLDPNVCAVCGNKLLVSEHEEGVLENTYKLSCNHVFHEFCIRGWCIVGKKQICPYCKEKVDLKKMFHNPWEKPHVLYGQLLDWLRWLVAWQPVILFLVQGINWSLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJW0</accession>
    <name>A0A232FJW0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_007819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000143">
        <property type="protein sequence ID" value="OXU30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJW0"/>
    <dbReference type="STRING" id="543379.A0A232FJW0"/>
    <dbReference type="OrthoDB" id="5808441at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="3">
        <location>
            <begin position="51"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU30607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="108" mass="11992" checksum="A6FD20FFDA54BF49" modified="2017-10-25" version="1">MRIPIKGRNSILVINAESKPTNEKCHNVCNSSGCRNEAEFLSKTINPAADPCYNFFEFACGNFVKNTDIHEDAAGIAILTMMDKELETKIINLLKKKIAPSDSKTDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FK50</accession>
    <name>A0A232FK50_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000102">
        <property type="protein sequence ID" value="OXU30963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FK50"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU30963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="161" mass="18466" checksum="92A0412A6949E8BD" modified="2017-10-25" version="1">MEEEQVVSDSNSDSDDDKFVSEGEAKKEEVLDASEFPCHGIPGSSVYVNGRCLIYRQPPMAPANMRVRYSLHEWTISYRHAVRGQFLIGTWESCYEEVWDLPEADEVCLLCNECRECTDRLRRLVGQEDLNLSTDSNFRDPRAPSARSKIEQLQMLIANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLS7</accession>
    <name>A0A232FLS7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_007204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000036">
        <property type="protein sequence ID" value="OXU31701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU31701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="365" mass="43860" checksum="6B46F7066A388EAE" modified="2017-10-25" version="1">MKKLAFTEKEKEFKEKIEEEVRKIRQEAEMAGKATKTGDETKEKEDKKDARTRSGSKYTVDLKQTTLDNRMKKLAFTEKEKEFKEKIEEEVRKIRQEALAMEKMKIEMKEREVELIERVDKVEKRMKDLEDREIDREAHWREEVDSRDGLNVEVLIGSNNIRTKGKVIVIKLNSAEDKETIMRNKSKLAGTKSFIEHFRSDEDRKMQEEIAAWVKEKREXMKIEMKEREVELIERVDKVEKRMKDLEDREIDREAHWREEVDSRDRLNVEVLIGSNNIRTKGKVIVIKLNSAEDKETIMRNKSKLAGTKSFIEHFRSDEDRKMQEEIAAWVKEKRERVYKNAWNKWEEKDKLLERLEVEERKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM59</accession>
    <name>A0A232FM59_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methuselah N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_011518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000033">
        <property type="protein sequence ID" value="OXU31752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM59"/>
    <dbReference type="STRING" id="543379.A0A232FM59"/>
    <dbReference type="OrthoDB" id="8191206at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013257651" description="Methuselah N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU31752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40779" checksum="E7DD85F80746F51B" modified="2017-10-25" version="1">MAVMARVPMLATLMLLLSLHCGLGVEVPESPNVPVTSSSDGDDITILHCCQPGYDLLSETNQTCVKSANSYYTEVYSPAKQSLVSFASTGWSTRYGTRPVCAGSSSLHFLKASKIDPFTLDEDNGNLLYELRIFVPTNQYCVGLAHALACLPNNDESFQAAATMRPRIRKCCGNNADYIDSKNSCEVSGSSSTLEDDREQLLGNNNHNGSSNNHTAGMEIISGFPVCQEQADNFTILAELRDTLLLPNASLLVNEQLVPSEEFCIERIRHNGKQGQHAKVFACSKHASKGSGPEAKDIRFTLYPVGFIISAIFLAATLATGFLLPASHHVLHWRCQTYHVACLMFGDITMAAIQLAGNSLKGDDWICPFLGMSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FM64</accession>
    <name>A0A232FM64_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_000785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000056">
        <property type="protein sequence ID" value="OXU31447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FM64"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="144" mass="16454" checksum="6944BD1803D99522" modified="2017-10-25" version="1">MKVDTTRQPPVYTLEDLESEKIDGYFHEQQLTPRTLLIALPHNSPKISVCSAIGASVSPKFKYLLPFNRSMKEESEGVVCITRNPTRATYTNNKLRNDDDGDDDDDDYRKTFSQIKCGVYDSLHTLLSEINNLDNVKDHLVFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNB6</accession>
    <name>A0A232FNB6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Magnesium transporter protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_004847</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Protein modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000009">
        <property type="protein sequence ID" value="OXU32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNB6"/>
    <dbReference type="STRING" id="543379.A0A232FNB6"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000009">
        <property type="entry name" value="Tumor suppressor candidate 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012782494" description="Magnesium transporter protein 1" evidence="14">
        <location>
            <begin position="26"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42932" checksum="94E4479C11C882AC" modified="2017-10-25" version="1">MFSMSSKMLLPFLGLLLLLLNDASCQYRTKSSQTASLSDRVQQLTDMAMKRPVMKFNTAKFKEFVKTTPRNYSVIVMFTAMAPQRQCQICRHANDEFVIVANSFRYSQSYSNKLFFALVDFDEGSEVFQMMRLNTAPVYMHFPAKGKPKAADTMDIQRVGFAAEAIAKWISERTDIQIRVFRPPSYSGTVAVVMLLILIGGFLYLRRNNLDFIYNKTIWGFGALFFTLTMVSGQMWNHIRSPPFIYKSPNGNVAYIHGSSQGQFVLETYIVMVLNGAVVLGMILMTEAASRKGDVKKRRIFTVIGLALVAIFFSLLLSIFRNKAQGYPYRYFEIIQNNDPPLQVNQKLTLDTAGTDMYYASQSHQDFCQKRLFNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNG7</accession>
    <name>A0A232FNG7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inhibitor of growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_004843</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000009">
        <property type="protein sequence ID" value="OXU32069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNG7"/>
    <dbReference type="STRING" id="543379.A0A232FNG7"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16857">
        <property type="entry name" value="ING_ING1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15584">
        <property type="entry name" value="PHD_ING1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000021">
        <property type="entry name" value="Inhibitor of growth 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028643">
        <property type="entry name" value="ING1_PHD_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF89">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU32069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="306" mass="34862" checksum="94DF3CFCA3081619" modified="2017-10-25" version="1">MLNQAVVEALYSATYIENYLDCVENLPNDLQRHLSRLRELDASCQAYLREVEQNQEVLARVDTNGSAKSRALLRIQQALIAAQEIGDEKLQIVQIVQDLIENKTRQLDMDFRNLDFGKEQETSEPARESNSNVNSNSGNNANNSERPTKRARRTRTETLVESAQAMDMIAMSENRSSNIQSSSNGNQKRANAANTGKKKKRKSRQGNQQNQHREDTPPPPEDDQAIDPDEPTYCLCDQISYGEMILCDNDLCPIEWFHFSCVSLSTKPKGRWFCPKCRGDKPNTMKPKAQFLKELALYNKEKEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNT9</accession>
    <name>A0A232FNT9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNT9"/>
    <dbReference type="STRING" id="543379.A0A232FNT9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7534" checksum="58E8EDB38E8E314C" modified="2017-10-25" version="1">MSQSDAPAIPLLKDVEKSPYEMLRYQKLDMERIGLYPNLDYKQLYNAISQLIDVIPSIHIGVQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FNY0</accession>
    <name>A0A232FNY0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000004">
        <property type="protein sequence ID" value="OXU32229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FNY0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU32229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="69" mass="7728" checksum="28B9BB923496E9B9" modified="2017-10-25" version="1" fragment="single">SNTYHKKIVTQEHVTLIKEAGSEYIGHTSPTSGHANTLPVVQFEKIEGQLPDIDKTQLSTDQNYLYQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDX7</accession>
    <name>A0A232EDX7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005798">
        <property type="protein sequence ID" value="OXU16559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDX7"/>
    <dbReference type="OrthoDB" id="7700353at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="162" mass="18520" checksum="445572CC1E639A32" modified="2017-10-25" version="1">MGKSSKFKTNPTKIISNIEKEFSAMSIYTDRSKSPESVSVGCASLTTDLKHICCTTNYKHNIQLYWIPAHVGIQGNELADQYAKQASNLTSSELVKIPYTDLKEQNKKITFANTNLQTQIQSAHKGTQYFKHYANTIRHPWFHKINLRREIITIDVDQDIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFN6</accession>
    <name>A0A232EFN6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_008200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004964">
        <property type="protein sequence ID" value="OXU17166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFN6"/>
    <dbReference type="STRING" id="543379.A0A232EFN6"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="299"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU17166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="542" mass="63868" checksum="5E94F040CE83263D" modified="2017-10-25" version="1">MYSDDYGDTDYVYDDYGQPEEHLEGYGRYSSRQMPEVVKKFLVLLRKYIKEGMIFEIQNLYENTFPKLSDQYFEKIPWPSDQQISHIVDDDHVFLTLYMELYYRHIYACMTPTLEQRVQSFYNYCELFNYILNENEPVSLELPDQWLWELIDEFVYQFQSFTQYKASVSQKTEEELEALSNNSKVWDVLCVLNVLHYLIDKSKIKSQLEVFASGGDPDSVAGQFGRRSLYKMMGYFSLVGLLRVHSLLGDYYQAIKVLENVELYKKSAYSHVPGCQISTAYYVGFAYMMMRRYTDAIRTFSGILLYVQRTKQLFTSRSYQNDQINKQTDQMYHLLAICLVLHPQCIDEGLQQALKEKKYYEKMYIMQCGGLDEFKACFLYACPKFLCLHPPNPNAIKEDYVRDAIEHQASVFMKEVVQQKMLPTIRSYLKLYTTLPLSKLATFMISNLQQTEEESEIDLKAEIAKLTIYLLCFKHKMKNIVWTKGASGLDGKFQSGSELDFYIDHDMIHIADTKVAHRYGNFFIRKILKFEDLNRKLHHIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFV2</accession>
    <name>A0A232EFV2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004927">
        <property type="protein sequence ID" value="OXU17231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFV2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8341" checksum="E838A17206AE008B" modified="2017-10-25" version="1">MRLSSRRCRRDDDDARKAQKFCNSAIFVQYGQIMHVESGLCLDASIVKIGEIMVAGTCSIKTPDQKWKFDHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG97</accession>
    <name>A0A232EG97_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_013393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptogyrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004846">
        <property type="protein sequence ID" value="OXU17348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG97"/>
    <dbReference type="STRING" id="543379.A0A232EG97"/>
    <dbReference type="OrthoDB" id="10041611at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF20">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="54"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU17348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="287" mass="31554" checksum="F68AF37C0CCAF2C1" modified="2017-10-25" version="1">MPARADGSALGQSSLLQRAFENFRFRPSVSRAKMDGGGAYGGGKAGAPFDPITFVQRPQVILRAVCLLFSIIVFGCISSKGYYPDKDGKEICVYNKDTNACNYGTGIGVIAFLASIGFLAGEYLFEQMSSVKTRKHYVLGDLGYVSCFFIELKLYAPFRFSSFSGFWAFLYFVGFCYLTNAWNSSERPPGGVGVNNAQGAIAFCFFSIFSWILKLGYCWNFQAGCAWFAFQRFKQGTEAAFAPSYEADPTGGQGYTSYPDATDAAYQEPPFAQQQQRGMGDFQAPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGR1</accession>
    <name>A0A232EGR1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004704">
        <property type="protein sequence ID" value="OXU17531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGR1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="5919" checksum="93E6803EB826D875" modified="2017-10-25" version="1">MAQKNQNQTKTDLRVETWNVCSLYRASAFKELIKETDRYNLDLVAIQKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGX8</accession>
    <name>A0A232EGX8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="NNAY01004658">
        <property type="protein sequence ID" value="OXU17593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGX8"/>
    <dbReference type="STRING" id="543379.A0A232EGX8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU17593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="140" mass="15924" checksum="34EB8778AE8E5EF8" modified="2017-10-25" version="1">MYCDITDCIVRLHIPEKLRQAAVDTVHGLLHPSGRGTMRTLKSKYSWPAIKKASLKWTKECIECQRVKKDCTALTTATAIFNNCISHYSSPLICTSDQGPQFRATIFKAFTRFLSSHKTRTSPYHPASNGIIERWHDMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHS4</accession>
    <name>A0A232EHS4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004432">
        <property type="protein sequence ID" value="OXU17906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHS4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="93" mass="10903" checksum="1B7DF7E41CB8DAC1" modified="2017-10-25" version="1">MIMNLRHCKYLDLYLGSDYDDVDDEDQNFPLLQLYKPKLYKRYKKYDLLIPPGLVKDSVQRLSINIRDNRSKRIALNVGRKGNAINGSNFLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHT5</accession>
    <name>A0A232EHT5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004421">
        <property type="protein sequence ID" value="OXU17929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHT5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="87" mass="9670" checksum="BC2146DB6A58DBA0" modified="2017-10-25" version="1" fragment="single">QGNNVARDRERASGREKIRELTLTVDGSNSLSGMLESRTSPSQASWRSRRLDGVEARMHKEASNVAVLLSQKAPLTLAHEFVILILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIJ3</accession>
    <name>A0A232EIJ3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_004319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004255">
        <property type="protein sequence ID" value="OXU18142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIJ3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="371" mass="42469" checksum="B07738B10858E99A" modified="2017-10-25" version="1">MVGVSAANAHGEELRAEESEAVRREAAAAVAVAPEALRLQVNETMEEEEEGKAVERAQNNHDARAEEAEDVPANRDSQRMANVDHLLATCTEPKAAANNILQHLMERAADESENIIEYAQHPCVKRRQQILNFLARPVEPEEMRYTRRSAEGLVTEHFFNQGNLRDLIRRGLEGFAKYPRALKQDIMRIMYVRRAQEIQHNHSDDSSCSFYKTIFPLSTSSSNSNTSVESQDYEADESDFSIQVGRVQRRIRIENSSSNNDDDDLSDYEQEDNQPSEENEEAEEDISEKDEEERSETDDDMNYQGVDEEGDKNIQTPGNRFDIFQQNSHYISKYKIEGRRIVLKIRSPPEDGSINSIVWLEIVIRNTFILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIR7</accession>
    <name>A0A232EIR7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_008168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004176">
        <property type="protein sequence ID" value="OXU18234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIR7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU18234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="229" mass="25633" checksum="77E79A69D4155D3C" modified="2017-10-25" version="1">MFVFDASSKIPSGLLAGNMFELGMYDECLVAKGISEGVEIRGRHCMYTITVTLGEGESLPFSPSISICIPDSCNGDDVISLFESFTSTNSNQLLGFGLKVTSATCLSIDQQVWDTEFIVCLFVHLTFFLGWLTAADAFAFCLFGTRSLMEPNYKYNIVYESFFTTPMNIDLQALRVQCDIPVKSLGLSESRRPALQPLKTDVTGQYQVFYLANFSYHLAEYLTLFTWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ11</accession>
    <name>A0A232EJ11_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004118">
        <property type="protein sequence ID" value="OXU18346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ11"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="23" mass="2520" checksum="A214635A681E1F8A" modified="2017-10-25" version="1">MERGKANGTNCILDRGAIKSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJ61</accession>
    <name>A0A232EJ61_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_015159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004087">
        <property type="protein sequence ID" value="OXU18393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJ61"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="102" mass="11401" checksum="F2AF55ADCCBA3D02" modified="2017-10-25" version="1">MGIKEFLPAPKPKLLPTPAVTESRGLFEGNVLLIVVVVVVNLLTLLILLFIFVLYVVHNWENRKAKPQVSMDVEETSEGSESTLFFYSKQRSKACGCAFSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJD6</accession>
    <name>A0A232EJD6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">OCEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_013055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004069">
        <property type="protein sequence ID" value="OXU18418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJD6"/>
    <dbReference type="STRING" id="543379.A0A232EJD6"/>
    <dbReference type="OrthoDB" id="6284217at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="9">
        <location>
            <begin position="464"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU18418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="583" mass="66829" checksum="09EF55F58E8D1F28" modified="2017-10-25" version="1">MRIQANDDVYETTRHRMHVAEENNKNKCTRVIKANEPIGIMPKHREPSVLTTSNQTFKSTPSQKTVLNHLPAHRSQTETQKKLTDVMRRPLKERLIHLLALRPFKRPELYDRITREGIREKEKNVIATVLKQIAFMRDNTYHLHRCVWNDVQEDWPFYTDQEKAMLKRRKPQNLTPPGSSDGGSSGSGQSPNSTHPGSPSTIAAPPSTLLGPKRPGYYQGNDGLPTKRQRISHYRKPDSVNASNVDNTRSNISSSIGSCLDKKQQRPQKFQHQPQIQSHVQQPNSYVAIKSDLISSSDSDDVNTKIVNKIIKPLDLPPTTTPSHIVHNQSNPSDYQYLQPKPQLEKHLYHDLPKDNKQSIKNIEDENSDTSLTEFETINVGNVNAPIHMSTEIITPDAQVDKEKEMDQYSESEMCLPFESSSNDKSLNNLANSTVEENFLSFSTSSCNQISRVPSESFQNTENPDYLTCYTKISSAEQRTRYKVEFYAGFKEYRKLLVQVVKIKEQFIQLEEELKNKQNTGNIEGIEAIEHQIRQEYAKRKSVYARYYYLHDKLGHIKKLVSDYDAQIDATSVSNLKTYSMFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJL9</accession>
    <name>A0A232EJL9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003977">
        <property type="protein sequence ID" value="OXU18544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJL9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="106" mass="11929" checksum="B98B7B2B4382B91D" modified="2017-10-25" version="1">MRQQQQRQLTGDESAQQWLGAAAPQGIKGASSSSSASCTRPNSNGTEQYGALFKIKLRHLDHRQKIIKLDFIVTNISTKVEESYRISAILGPIQEFSYYKKIIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJT7</accession>
    <name>A0A232EJT7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Torsin-1A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_005535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003942">
        <property type="protein sequence ID" value="OXU18616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJT7"/>
    <dbReference type="STRING" id="543379.A0A232EJT7"/>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="3">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU18616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="377" mass="43019" checksum="EA68BCEF3E5B4892" modified="2017-10-25" version="1" fragment="single">QKAFSRIKILDFGACASVGGAVDDASVLEDYMSSFKLRIRMGHYIILIILSTLCSFTHGGLFDNVISWYCDIYECCDNKRVPYNLPKLKSMISMRLQGQHIVENVVFNAINSHMKKSKKPLVMSFHGANGVGKTYVSWMIAKAFFKKGENSRFFHFYYGLQNFPNKEKVLEYQTQLKSDIEAALHSCERSMFVFDGVDQMPSQLLDALMPFIDCPNCAGKLEKNKSIFIFLTNTGSSAIEKQLLRKINDGINRENTTLQDFEKLIIDAAHNHSGGLFESLLIDSQAIDFYIPFLPLERRHVKYCIREALEEIVETPKLVTPDLVEKVFEELRFGPEPEALFSNSGCKRVALIAGRLAAMKYTKFDYFNEEDNHRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK37</accession>
    <name>A0A232EK37_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_011753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003883">
        <property type="protein sequence ID" value="OXU18719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK37"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="48" mass="5417" checksum="8161D3911554CE9C" modified="2017-10-25" version="1" fragment="single">SWLTVLAIPGDYTRRSLACTYLCGTDLSSKGSLMYALPRDRFSTLPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EKB1</accession>
    <name>A0A232EKB1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA-processing protein UTP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_005200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003819">
        <property type="protein sequence ID" value="OXU18804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EKB1"/>
    <dbReference type="STRING" id="543379.A0A232EKB1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09866">
        <property type="entry name" value="PIN_Fcf1-Utp23-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU18804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="250" mass="28544" checksum="EF93C80291028958" modified="2017-10-25" version="1">MKIQRHKKVQKNLGFFVNNYKFRQPYQILIDGTFSFAALENKFNINEQFPKYFQAEVKLLTTQCVILETEKLGPKLYGAMLIVKKFAVHKCGHEKQPVSGSKCLRSMVGSNNPSRYLVATQDRLLQDQLRKVPGAPIIYLHGKAPTLEPPSQISREFAEQIRNNTIMTDVQEETIKTMMKQSGLETENSFKPKKKRSKGGPNPLSCKKRKKKDDTNSNTSGKKVNETGKVRKRKRIKLPAHVKEVLKANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL01</accession>
    <name>A0A232EL01_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_009975</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003696">
        <property type="protein sequence ID" value="OXU18992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EL01"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003492">
        <property type="entry name" value="AGAP012735-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="955"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1527"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1599"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1639"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="300"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="846"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1165"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1441"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1707"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="2173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU18992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="2173" mass="245669" checksum="346084852D03D568" modified="2017-10-25" version="1" fragment="single">MLHDLKITRRRLSTTYKIRYTYVCEALIVAVAVTAIVKNIVYFKGILTASENIHNSMFASLIRTPLRFFDVNPAGRILNRFTKDVYSIDESLPKVGFDAIDNLFSCVAIILPILIVNWWNVLPVIIAICSYYSLWRMTVSTIVGLRKLQNNAKSPVLSHAASSLSGLLTIRSCDSQQLVSRIFDLWQDRHTSAYYLTMMFVTSFARCLELMTSFFWVAVAYGSVALKNDNVYMSDVGLTLLQLRSIGFLIQLSFRQTTNVMQEMTSTERIFQFVDLEKEDDAEIELPIKVGKEWPERGEVIFEHVYLKYSEEAEPVLKNLTFSIQPRTKVGIVGRTGAGKSSLISALFRLTNFDGTISLGGIDIKKIGLSDLRSRISIIPQDPVLFSATLRDNLDPKHEFDDASLWSALEKVEISKTFDSLDRCIEKGGRDLSVGQRQLLCLARAVVKRNKILVLDEATANIDAATDEVIQKTIKVAFEDCTVLKIAHRLNTIMDSDMVLVMDNGEVVEFDHPSVLLQKSDGYFFKMDPVLFSATLRDNLDPNHEFEDASLWSALEKVEISKTFDSRYRWIEKGGRDLCVGQRQLLCLARAVVKRNKILVLDEATANIDAATDEVIQETIRVTFEDCTVLKIAHRLNTSMDSDMVLVMDNGEVVEFDHPSVLLQNSDGYFFKMLLCLARAVVKRNKILVLDEATANIDAATDEVIQETIRVTFEDCTVLKIAHRLNTSMDSDMVLVMDNGEVVEFDHPSVLLQNSDGYFFKMPNPKIKACIISELLFWWLKDLFLYGRKHNIVENDLYDALPEDLSEPLGNELEKSWEHELDEAKAEKRKPKLWNAIIKTYRLKFLATSVILVIFSVASIMAPIVQQELLQHFFSSSTTSDTQAYLCATIMVCLIFTQTFTFNHAFVGLSHLGMKARLACTSLMYKKIMRLSCHSTIGNTSGNIMNLMSNDVSKFEYWSFFIPFLVIVPLEVLVTTYILWWFIGYAAFVGVGLMILQTLPVQATRVVVTYRLTLKGRSKMTARMDQRISTISEVISGIRAIKMFVWEEPFEKLVYHYRKLEIKVQMKLWTIIAMVCALGVFAHRLAVFISVLFYMIQYETISVITVVLVVQYMFVLRGSLIFTFSNGLRALADVNVSMKRIENFLMLNEMKSSVRRNELKSDAAIVIRHVTTSWQTDLIEKSLDDVHVNVDRDKLYVVIGSVGSGKSTLLKLILGEVNPIQGEVHVNGIVAYASQEPWLFAASVRDNILFGEIYDEERYEEVTKACSLMDDFSQLPYGDRSLVSERGSNLSGGQCARINMARAVYRDADVYLFDDPLSAVDTHVAKRLFEECIDGLLKSKTRILVTHNLHYLERADTIILLDNGKVEFVGSYSEINKIEKYALLSSDNLKRDQTVADENDKSKRSFGNINVETKLDSFKNINNNFVEDDEPKETEELLAKGYVAKSVYWRATVNAGEKVHNSMFASILRTPLRFFDVNQSGRILNRFTSDTGAMDELLPRASFDAVDNILSCTAILLPALIVSPLNVIPTVIAAFLFVKFGSIYFATSQAIKRVESNAKSPFLSHAASSLSGLLTIRSCGCQNLVTRIFNERQDRHTSAFYLVLLTSTAFSTGLELIVHSLWIFAAYSSLALKNTSSISIGHVGLALMQLRSIVFIFQWCMRQAGETINLMTNVERMFQFVDLEKEIDAEIEPPIKPKTEWPDRGEVLFDNLYLRYSDNAEPVLRNLNLKIPAGIKVGIVGRTGAGKSSLISALFRLAKIDGTLSIDGIDTKKISLSDLRSRIPIIPQEPVLFSVSVRDNLDPNHEFDDATLWSALEQVELNKTFDSLDRNIDRGGSNLSAGQRQLFCLARAIIKRNKILVMDEATANVDQATDEFIQKIIRIVFKDCTVMTIAHRLNTIIDSDRVLVMDHGQAVEFDRPDVLLQRNDGRILNRFTKDVYSIDESLPKVGFDAIDNLFSCVAIILPILIVNWWNVFPVIIAICSYYSLWRMTVSTIVGLRKFQNNNDHQFKSLSFRQTTNFMQEMTSTERIFQFVDLKKEDDAEIELPIKVGKEWPEGGEVIFEHVYLKYSAEAEPVLKNLTFSNPARMKVGIVGRTGVGKSSLFRLTNFDGTVSLGGIGIKKIGLSDLRSRIFIIPQDPVLFSATLRDNLDPNHEFEDASLWSALEKVEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EL17</accession>
    <name>A0A232EL17_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Nucleolar protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TSAR_001365</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Alberta</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003650">
        <property type="protein sequence ID" value="OXU19050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EL17"/>
    <dbReference type="STRING" id="543379.A0A232EL17"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000005">
        <property type="entry name" value="Nucleolar protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000006">
        <property type="entry name" value="Nucleolar protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="181"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="13">
        <location>
            <begin position="322"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="14">
        <location>
            <begin position="466"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="15">
        <location>
            <begin position="656"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="16">
        <location>
            <begin position="854"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="17">
        <location>
            <begin position="1010"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OXU19050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1151" mass="132063" checksum="C52F6A2F6E9E0E6B" modified="2017-10-25" version="1">MIDHKKQVVDPESPTEMDSEADEDLEERLEKQKPLVKINKKRKNSENDDPSAKKKGKVEKGLYKQPTVEELNQLRETENLFHSNLFRLQIEEILSAVKLKSKYQKLFEAWYEKFETHVKSIKGTKELSLEDNTLFNKFNVKIPMAKLPNDCVGTLKYSPPSSITVAGSYALETIVGPEASIDILIEMPENLFSKIDSKNYRYMRKKAIYLAYITSKIGKDLAETKSFIGNHSNPILKIVPTGKLGSKFVVHVHVVVQETSLPPNKFTPEKNNVKPNWFFKATDKNTDNNPPTPYYNSAILHDLTALKANTQNVKLIKEYPNIRDGIVLLKIWLKQREFCNNYETFNGHVITMYVLYLLLTKKLNTFMSSYQIVRNTWQHLANSNWCKEGISLCQDEKIAARIAEYHKHYDCVFLDFTGYYNIAANIQEDVFRWVSNQAAMSIECLNNTRVNGFQVLFMRKVPFYKAVDFVICLHNVKALENILDVNSDESDKLNYGPNKYVPIIKLISTFLKQGLGQRASFVCSFPRKLREWQTNEEIPNDLERIYIGLKLDPHHAFNIIEKGPGANLPEAEAFRKFWGHKSELRRFKDGTICEAVVWAKPNATLAQKRDISQRISKYLLEEKLKLFEKAHYFFFSNQLEEFLKLKKVKVRGFHYGPEEAALQVINTFAGLEKDLSNLTDLPLSINGLQGCSPLFRYTDVFPPLATVRKTDDKNVLDTPSHLRFVENGDVDEVPMYLAPVEVTMQLSTSGKWPDDLQALRMTKAAFHLQIAQSIRKQCKIRAQGCMHYIDVMKDGLVFRIRIANQREIGLVKQQVDEDGVTKYRDNEESLELEKNLFHLPKITGALYGLYCQQPSFGPACCLAKRWLAAQLIDDSHMPDIAVELLVASMYLNSDPYEPTTAPQVAFLRFLESFAREHWSTDPIIVNFNNEMTREEIVEIENTFGTSRETLPSLFICTPYDREASIWTRKAPTPIILKRISALAKEALRLLEVQLFSETSVCCDPLFNPPLSAYDCLIQLKESLNPRKHEATAIVKDDLPTKDLYPFKEHSKTRIPIVGFDPVAEYLSELRKNYSEHALFFHDTYGGNVVGVLLKPQAMQQKDFKVSNTSCQKFNDNQKLILNVSAMIEDFYILGKGLVEIINIQSDKLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EM18</accession>
    <name>A0A232EM18_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_007258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003449">
        <property type="protein sequence ID" value="OXU19400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EM18"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="73" mass="8954" checksum="EDC099152467B899" modified="2017-10-25" version="1">MHTYFWILNSGKQLFFIFSTIFFYDHFLIFEKHYFAFVFFNHPIVTNDSAIMHLKKNKITYFSSFGARDRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMI5</accession>
    <name>A0A232EMI5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_003801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003361">
        <property type="protein sequence ID" value="OXU19551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMI5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="201" mass="22213" checksum="567984C736E7D0C1" modified="2017-10-25" version="1">MRILCVAESNVRAGYRYRIGLPLLPPTHDPMLSQYCEDRAADEEVAAILASVSPINVAPLVMFAVYGSPQLLYPELGVAVDNESVVGKKEEEVARVWEVQDAVENAERIFAKQAEAQALTQEEEEAARVRLLRDAEAEESMEEEENEITEEEEASEEEGEEEEAHDSGVDSDADDLMDESSSASSSSDDEDVPYDSVRDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMW7</accession>
    <name>A0A232EMW7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_002499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003287">
        <property type="protein sequence ID" value="OXU19678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMW7"/>
    <dbReference type="STRING" id="543379.A0A232EMW7"/>
    <dbReference type="OrthoDB" id="7699407at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU19678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="158" mass="17387" checksum="A6EF035EB7827812" modified="2017-10-25" version="1" fragment="single">EVEQSRPSTVDAGADQQDSSTGDRSRVASHPVLVARKPQLINTRIRTPSSALFHPHIFCHSPAPPHSQSGDPDVIRQCNVQKRTPTGRIELASIGAKSESSEDTKNDRINRIAFRAPPHVPNEPEMWFSQLEHSFASAGISGEASKFSYLCSTLDPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN89</accession>
    <name>A0A232EN89_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_009200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003207">
        <property type="protein sequence ID" value="OXU19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN89"/>
    <dbReference type="STRING" id="543379.A0A232EN89"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="19188" checksum="C0DC897249547D1C" modified="2017-10-25" version="1">MALVYTRLLCRRNLDLKSFRCLYTSNPTTVCSSLPALKPATTACETHDEKNMRLKRPLSPHLTIYQLQLTSVLSVTHRGTGIVLSSYAMILGLGTLFVPGGVPCMVQAIAAWGLPSAVLYVGKAMFVYPLTYHYLNGIRHLTWDLGKFLTIKDVYRTGWTVVGLSAIAALAIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EN91</accession>
    <name>A0A232EN91_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_007492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003205">
        <property type="protein sequence ID" value="OXU19797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EN91"/>
    <dbReference type="STRING" id="543379.A0A232EN91"/>
    <dbReference type="OrthoDB" id="498368at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000005">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU19797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="613" mass="68507" checksum="3E7937782859DCA0" modified="2017-10-25" version="1">MANTTISKKRKFVGDGVFKAELNEFLTRELAEDGYSGVEVRVTPQRTEIILMATHTQSVLGEKGRRIRELTSVVQKRFNFKEHSVELYAEKVATRGLCAIAQAESLRYKLIGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGEPTNDYVNTATRHVLLRQGVLGIKVKIMLPWDPNGKNGPKKPLPDNVIVQEPKEETLYSAPASEAKVVKDLPAPPPINACNSRRLLLCFVAIPIKVEPDTSLEDAKLFEAYVQDYKKPYKNDPDEYERRFGRFQQSLRKIESLNRLRSSADSARYGLTHYSDMTEQEFLALNLRPDLSNRSEKHHQCHYHHTHSDNKRYERAVTVLPDKFDWRTKGAVTAVKSQGSCGACWAFSAVETAESMFAISNKTLRAFSVQEMIDCAGNSNFGCEGGDICSLLDWILVSKTKILPEVNYPLTRTTDACKLQKTATKIQEGICISDFTCDNYVGAEDKLLKVLATKGPVAAAVNALSWQNYLGGVIQFHCDGSFKSLNHAVQIVGYDKTATTPYYIVRNSWGPSFGDKGYLYIAIGSNLCGSYLRYGILYKKYCFHYSFIIPFAGIANQVSSVDVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENN1</accession>
    <name>A0A232ENN1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_011077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003106">
        <property type="protein sequence ID" value="OXU19964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENN1"/>
    <dbReference type="STRING" id="543379.A0A232ENN1"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="85"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU19964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="302" mass="33926" checksum="0B57F9751ED22300" modified="2017-10-25" version="1">MSEENEKEASGIMVRLAVNRIDQNLPTHQDPQVFLYSPGEEISTQPDFLRGHGTYVDEQEVLRASVAGRLERVNKLISVKPYKTRYQGEIGDVVIGRITEVQQKRWKVDCNAKLDAALLLSSVNLPGGELRRRSVEDEQAMRRYLQEGDLICAEVQSIFADGSLSLHTRVLKYGKLSQGIMLKVSPALIKRQKTHFHNLTNGACLVLGNNGYVWIGANVADTDRSEGGFTQDLSRVSQEDREVCARLRNCILSLAKSHILLSDTSVTYAYEESMKYSIHEMLIPEVQLDVALLTHQRLTISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ENU5</accession>
    <name>A0A232ENU5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003092">
        <property type="protein sequence ID" value="OXU19996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ENU5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7340" checksum="AAE46D46CAEE2FB8" modified="2017-10-25" version="1" fragment="single">MLSESSASEDNIHCFVYGFIDDSDRLLNVQGEIGRYKLVGDSQRMESKLEKLYYGLPARDQHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EP95</accession>
    <name>A0A232EP95_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein Di-Ras2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_016588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003006">
        <property type="protein sequence ID" value="OXU20136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EP95"/>
    <dbReference type="STRING" id="543379.A0A232EP95"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU20136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21833" checksum="24A32B66349F16F8" modified="2017-10-25" version="1">MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRESYVPTIEDTYRQVISCNKNICTLQITDTTGSHQFPAMQRLSISKGHAFILVYSVSSRQSFEELRPIWAVIRELKGQDISQIPIMLVGNKCDESPSRREVTQSEGEAEATNWGCGFLETSAKTNHNVNALFRDLLTLEKNRAVSLQPVQSNNAISLKEKCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EPK9</accession>
    <name>A0A232EPK9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002916">
        <property type="protein sequence ID" value="OXU20319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EPK9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="7802" checksum="88D1061DDDE2F700" modified="2017-10-25" version="1">MTGILKSLGHGTNQAALQIYSSVSLFFNYSELKNKYLVPGNVVSNYCASLESKSRLCNIQTKDKNEIKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQ49</accession>
    <name>A0A232EQ49_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-actinin, sarcomeric</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_001427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002827">
        <property type="protein sequence ID" value="OXU20484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQ49"/>
    <dbReference type="STRING" id="543379.A0A232EQ49"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000003">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000088">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000148">
        <property type="entry name" value="alpha-actinin, sarcomeric isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="128"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="796"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="837"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="721"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU20484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="942" mass="108561" checksum="1207117C46068B06" modified="2017-10-25" version="1">MRDEIGFSAFTELAYSESATFTAWCNSHLRKAGTAIESIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYHKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDGMEDTIWNLPMTIRLTVCFILFTCTLLYSDIDLINTPKPDERAIMTYVSCYYHAFQGAQQNLDSLIDMRNTAMPDERAVMTYVSSYYHCFSGAQKAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQTDNSLAGCQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYMPTEGKMVSDINKAWKGLETAEKAFEDWLLSEMMRLERLEHLAQKFKHKADAHEDWTAGKEEMLTSQHFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDSASVNARCQRICDQWDRLGTLTQRRRQALDEAERILEKIDVLHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLMDAHSAFKATLGEADKEYNSIVGLVREVESIVKQFQIPGGLENPYTTLTALDLTKKWSDVRQLVPQRDGTLAAELRKQQNNELLRRQFAEKANAVGPWIERQLDAVTAIGLGLQGTLEDQLHRLKEYEQAVYAYKAHLEELEKIHQAVQEGMIFENRYTQYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGITQEQLSEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDIDFQRILAIVDPNNSGYVQFDAFLDFMTRESTDTDTAEQVIDSFRILAGDKPYILADELRRELPPDQAEYCILRMPPYKGPNAIAGALDYRSFSTALYGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQL3</accession>
    <name>A0A232EQL3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002749">
        <property type="protein sequence ID" value="OXU20631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQL3"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="40" mass="4336" checksum="C4D9F2154060F560" modified="2017-10-25" version="1">MPPGPNTRWRSHGMEIAGSSASRCLAPWAEAARRRVCIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQN6</accession>
    <name>A0A232EQN6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 138</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_008476</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM138 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002746">
        <property type="protein sequence ID" value="OXU20637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQN6"/>
    <dbReference type="OrthoDB" id="189688at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024133">
        <property type="entry name" value="TM_138"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13306">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13306:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14935">
        <property type="entry name" value="TMEM138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU20637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="162" mass="18892" checksum="CC60F7E902FAD5EC" modified="2017-10-25" version="1">MGHLTPKKYTFTLILQYLFLLFDLGVNSFATFARSHPADLLVLFVVQDFCLIMSLTILLANFFSTYIFQAGLIQLLYAQFRMTLLICVTYIVLSISLHSWHMTIHWSAPLTHFWSVGYHSLYSVQRTIAVLYYYVSKRASLCISDPRYHEGSKWMQKQFSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EQY5</accession>
    <name>A0A232EQY5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_010092</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002710">
        <property type="protein sequence ID" value="OXU20727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EQY5"/>
    <dbReference type="STRING" id="543379.A0A232EQY5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU20727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="58028" checksum="0B9799FD4F9E499B" modified="2017-10-25" version="1">MDSTTWLLVVSAIVLCLSVYYKKKRHSFKDWGIPQPFEVPYLGSVPRNLWKNYHLSDLMKDMYNFNKEAKYVGMHTFMIPVIIITDIDLVKTVLIKEFDHFADHRELGDAVGDPLLTKNLIAINGDKWRELRQLLSPAFTSSKMKLMFELMSDCADRFAKSFSEQFLKEDDTDMKKAFTKYTNDVIATCAFGIEIDSMKNPDNEFYRYGREVTNTDGLAQLRAIYKMLFMIMFPRFAKFIGMELMREKISKFFIGVIDEAIKQRDEKGTTRPDMLQLMMDARDKNSKLDLVEMTAQAFLFFVAGFETASSNMSLMAHEIAVNPDVQEKLHAEIDEVSEKSGDKVTYEAIANMPYLDAVFQETLRLHPQLAFLSRVCSKTFELPPALPGAKPYVMKVGEEIMIPVTGIHQDPTFFEEPTKFNPERFLEKKITTTGDPKSLGFGMGPRMCIGNRFAILETKVLFFYLLRKHTLQPCSKTCLPLKYHKFKVGPIPKEGFWLRVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ER41</accession>
    <name>A0A232ER41_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_005454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002663">
        <property type="protein sequence ID" value="OXU20833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ER41"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="70" mass="7636" checksum="58C1104863E4FC52" modified="2017-10-25" version="1">MPWPGSRSAYMPSKALRLFGEYGSRLAAARDTSGTVGALRRCGTVERVADIQGLVRESLRVGYNSLILCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ERN8</accession>
    <name>A0A232ERN8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_007116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002585">
        <property type="protein sequence ID" value="OXU20987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ERN8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU20987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="469" mass="54360" checksum="21D3A52D5044745D" modified="2017-10-25" version="1">MSKRKFTQFPYTDNFEELTNYMKKKIKRMIKNEHNSKNAQLDYAVQGLTEQNETEENVSIKDVEQINKDHTIDWHKADDESTPHLEILEMNESSDWQWENNIEVSIQEDNHCNNNVILDILKNFSSKSDTKLEDQLFKSVNAHVDKSFGELFLISLKYCLSGKLPFTEIVNLMKLINIICGKKILPDTRYEMNKLCNDFDSITFHSVCSTCSAYNGEYKDFRGTITCELCGTIVDVSNPSNSCFFAIIDPSNAIRKHLKAHEDYYSYIMNERVHEKNQLNDIYDGKLYREFISTLSASDKNKYVTAVMNTDGAPEGTYFEGSMRYPYVTPLPLERTKENTIEFAKEALNIGQPVFGVKSASPLLLLTSFDIIRGFTPDYMHCVLAGVVTQLTDCILCDLPNSDIENIDQFLLNIKVPNQLCRLTRSLKDRRNWKAREWENWLLYYSVPVFNAIMKKKKEIRTIQLIKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ESS2</accession>
    <name>A0A232ESS2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retropepsins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_014800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002385">
        <property type="protein sequence ID" value="OXU21392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ESS2"/>
    <dbReference type="STRING" id="543379.A0A232ESS2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retropepsins" evidence="2">
        <location>
            <begin position="87"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU21392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="293" mass="32625" checksum="47890CE5FAB6624B" modified="2017-10-25" version="1">MIKLIDLKTKSLGSGSGDRGVSHVKIDLPTYSGAPFEQPIRFLNNFFNYIEAIGTTEHAAKYLIEQALRGTASDCTPYKKPESPLCPEIQIKIGSVPTTALLDTGSKLTCVSSEFYERYIHEFKDYPTFPLTGIKAIGFIGEKSISLKKQFRARVELQSLSIDFNFIVIPKLISPYILGIDFQDHLGAVIDLRNNSAFFVHPESSTTVECDFLLRDFRVTDRNEVNALLAVSHHDLDHDHSNVPSLNVYPVEESDTLTDAEINEKLKTIAGHSEAELLSLGGINHLFRVGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET19</accession>
    <name>A0A232ET19_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alkaline phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TSAR_009716</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Alberta</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002345">
        <property type="protein sequence ID" value="OXU21501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET19"/>
    <dbReference type="STRING" id="543379.A0A232ET19"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013325600" description="alkaline phosphatase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OXU21501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="523" mass="57512" checksum="3929DA8A079F6ABA" modified="2017-10-25" version="1">MGSLNFVFLLLLFNFASGIKEDKKHWQEVADKELRDALSYSWNTNTAKNVVLFVGDGMSPDTITASRIYRNGEDSYLAWERFPHVGLLKTYNSDKQAPDSASTATALFGGVKTNYNVHGVDANVTLNDCEASLLTANRVESIISWAQASGKSTGFVTTTRVTHATPAPLYSHGPNRKWECESTMPKEAAKCKDIARQLIENEPGKSIKVIMGGGRQMLQTHVWETETDPIDTWAGRRQDGRNLINDWITDKKGKNAAFSVVQTNEELAAVDHKKTDYLLGIFANGHIPMDFKRDKSPKGQPSLEEMTVAALKILKKSDEGYLLVVEGGLIDFAHHRGHAAQALLETVRLSDAINATLELVDSEDTLVIVTSDHTHSLAFNGNSARGANILGIADVSKIENIPYTTLSYSTGGPNNIAYQVVNNKSMRINPNESDTTEFTYSQQAAIITDEAHHGGGDVAVYALGPYAHLFHTTHEQNFVAHVVAYAAKIGPYANRSSTGNQWNMIWVGSLLGLILTINVYWHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ET45</accession>
    <name>A0A232ET45_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TSAR_001722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Alberta</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002335">
        <property type="protein sequence ID" value="OXU21523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ET45"/>
    <dbReference type="STRING" id="543379.A0A232ET45"/>
    <dbReference type="OrthoDB" id="10052888at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012285600" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OXU21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="723" mass="80120" checksum="E0E527509A8AA535" modified="2017-10-25" version="1">MASEVISVLIALVIVCVFAEPPVQIDERHLQPNHDQDDNTGNGWQDSVPGLPGRDYPNLTSIPETSFTCAGKTPGGYYADVETRCQVFHVCSTNGAKSSFLCPSGSVFNQRHFVCDWWYDFICEQAPELYALNRGLDDRLETPSTRPSLPIDPSLQFNSIAGPGGDLSLASSGYPNNIRDDANSIYEDYTSVKIADSEPAKEKFPSVAASSAPSASVQQLGDSSQATTSGIPADNYSEARRHERLSSQQQHQTRGRNHEEHRRPLTYRRRPIHGLDNVPRGFSKDHAEEEALAKGANQGAGSFVNNGLADESERNTNFPLPRENNNYVDSNNYNNRLNAADNDNQNNFNQNKAINDFNGNNNNDRFENYYQSTGSNPLVPQNSSRVNENYKYTTNNNNNNNNNANSNYYNGNNVNNDVQSNNYYNQNNFNDNNQNSNYNYYNKNNINSNEYYNPGNNNIKYDNYNRKAESVESSTVNSYSTHYDFPKDHQTQTSELSTSRPRSINSSPTEDDVDRERQREVDSADLKRKRPQPRHQQSYDNQSPAFLIREEFTPNIWRDDLSTSSTASQSPPYPPDRGYLRQGSDTSTLSRPVEVTTPVASTTVSYPKPKPQERPKFLGRRPAGGLPSGAGNGLPGANKVLIGSDAITNTPGEESAGAGDNSESGVTASGVKGNGNGVNGWGDQSSTYLPPQTYNEFGGDSQNNNWNNAGQRWNNGGNYDGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ETS3</accession>
    <name>A0A232ETS3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Multiple epidermal growth factor-like domains protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_014735</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002229">
        <property type="protein sequence ID" value="OXU21760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232ETS3"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000191">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000202">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000023">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF16">
        <property type="entry name" value="MULTIPLE EGF-LIKE-DOMAINS 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013167133" description="Multiple epidermal growth factor-like domains protein 8" evidence="17">
        <location>
            <begin position="30"/>
            <end position="3031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2880"/>
            <end position="2902"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1272"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="20">
        <location>
            <begin position="1395"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="1417"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1615"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="20">
        <location>
            <begin position="2448"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1417"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1641"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2468"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2480"/>
            <end position="2494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU21760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3031" mass="339996" checksum="EE0016CB391CEB9C" modified="2017-10-25" version="1">MGLAAIIALWIVTWSCLLRGLHLAPQTSAKQVPCDKTRKIFTESWGVISDGPKGSNYTQDSHCEWLIKANNSRQFITLSFRTMGTECSYDYVFVYDGDSFRSPLLGSFSGKTEPQQVTSSSGYMLILLYSDTNYVLDGFHAEFSVTDCPNNCTNHGKCINNTCFCENDWGGKDCSRTLCPNNCGVGGICGLKQWHWLSHSEGGMTPRAAHTAVYVAETDSLYVFGGYNLNYILSDLEIYRFSTSQWEDEYGIVLEGSSSAEYLDPVLIASELEHMGAGAHEQYGLPTSIFWKLLLSFKENSTSYLRPTDDSSSRAWWESKISEHRERDRTSQHVTKTNDTHENPDRKKHTRRIHTQSRSRHQRSADNSLHYRQRHVSSINDNPNWEERVVKSPMEENAFLQDILEPQFTTQIPLNDDATEPNLEELPKPSPRYGHAACKYTGGFVIYGGKVEDGSLSNELWYYNVNKTLWTLRAKNSPFYPPRLTRHTLTLANEYIYLFGGSTVDGEFSSSLYRIKLNLSDSTASTEKWQEVRPRGGKELDVRVVAHSTVYHQATNSLLVYGGVVASVARFSKLSDRMFVFQLDRRVWSEIHYPRAHLRDTYVPRERAFHTCNIIGNYLVVFGGYSHRHNKEEICYDNQMYLYHLGCHAWVSHDVLNTSDKDSQYPKQQGVFAHSADVRNGNTLLLVGGYHGNVNADLLAYTLPPMLAPGDGDLLEPEQFCSRHKSLFECAANPECGWCSADENCYGRTVVSNCTTNLQTTRCPGVCPALGDCHSCLIHGQPGGGWGTNSRGRSSVSNKFNLGTCTWCVQNARCHHKDDNYGVCGLRDDTPSQIPGWWGTKGTEIARVEECREMDRRPGLTFLKYKPPVNFTQPDSVTIVNATTVDFNVPSMQGAKTESALGGEMIARLVGFLRLPHNIWDSKSELLKICVSYNSATLHVSRNNDTQHMVLVANLTAETSQCIPTRTSEEPFTVSFSPGRYLLDFESKRMVTASYAHSSKMEITHNRHAENPKVFTFEYLEPYQNGSCDQYKNCLHCLTDSACGWCDINNKCLSRAVNETESCVADVEWDENSKPVREWHYLTITPSTCANCSNYISCESCVKTNICEWWTEEARCARMGRLPNAVVSLEQCPVPCRQRSNCTQCLDERGRCVWCEATQECFSFSVYTSEYQFGLCREWTDQAGLMGVTSRSSSSLTGNDQCKSCSRHNNCSNCLHSLSCGWCYSLENPILGACVQGDFNQAHVNCSQVINELQNGTLEVGEAGWAYAQCPDVDECDLGLHDCHPNALCTNTHGSYSCQCKRGFNGDGKENCTKTCYEKCVNGYCSEAPDYKCECYLGWTGPDCRTNCGCYNHSTCIAGPGICDECQNWTEGRYCDECKAGSYGNATTSLGCQKCDCNEHGDAALGTCDRQTGICFCNDNTEGDRCEMCKKGYYGDPRHGGMCYYGCMSRGMLEGEGNGKQGLGSRHSQLSLWESHLGGSPTRECLWIVSPKTGLSSDTMTPAVQSAIQFTIHDDINVSCQENSVYVYDGLPAFVSTMTSHQSQLLGVYCTESTNYPVTVEAKSGFLTVHYKQLDEVEGFNASYVVMTCNNCPANRECRGGNCLCKVGFVGINCDIELCPKNCSSARKQGICDKGYGHCVCAPGFGGRDCSISIKDNQLVFTELFNSEYLADQLDHLRKTLPRFGHTLVADRRGSLWMFGGYSLSHGPLNDIRLFDTKNSTWMPVTVESTSEASMPQGRYFHAAEIVHSRQQIYVYGGLSMKEEGVHGLSNNTLSDFWKFSLQNQRWMLITDDSPIKKEPPPLAGHTLTLYRDGGESESLILIGGFSPRYGYLDTVWEFNLETETWDTVPTVGNGPLGVYGHSTVFHSRSNSFYIFGGYTYAINRTFISNKLYALDYKTKTWSVLPPFDDESSDGTPQARFLHSAVTTDEYMVIFGGRQNPHNTTDSLIAYKYSCNLWIRLITKDMEIIGNSPPPAYAHAMTHADPESNAVYVVGGFDGGIKSHVTLIHIPEDLCNLWTDKITCRRYYGCSFCSVTTIAGDNASYCFSNEESLHRDEKCDVNVTKAHRSNGIFCNSEWMSSRKCESFKTCTDCLAEWPYYKEKQPVCKWCIDCHGKCIPADKDCDEQNKCKHWQKLVTDVNQCGERLCPASDCEKCKNCQGNCVWTRQVLKTSELGLKLTAEPVYDWNCVPEDIFNRSSIKMTSTQCEKRCSEHKDCKSCLKGTGAEGGWRECRWSTQLNECISPSYQPLYCAGGVCGLVLRSVDVEHCPEPCSVFKQCSTCLKHSHCGWCSLDSTNITGQGICTEGSLEAPPGLDHPAGGTCEMLYYQQYPQAETSITTNIPPHELDFRDNVSIPLTNIGTTTSSLKFSWHYVRCPPENECINGHHTCSPKSEKCFDLDEGTHMYNEYGRKTCVPMCTQGCVRGTCIEPDVCRCDFGYVGRNCSIQCQCNGHSNCEGPDKLNNCLECHNNTMGSQCDKCLPLYVGNPADNGQCVPCLEYCNGHTHICINENMTVPDPNSIDKMPIELLKKQLVEGPVSKAKCVNCGNNTKGDKCGECVTGYFRGTEDLRDVCRPCECHGHGFTCDPVTGEQCDCRNNTESEPSCVSGPSKGGNSGQTPCWMVQCSKCRENYAGTPTMGHQCYKTVTVDNKMCFDSKLIDECKVKPKPLNPGQTVFYMVQPRFMNVDIRIMVDVTQGALDLFLSPRDDTFVVTMNSSTGFQEASPFIFLYFFNFHDKYFKLNIVELDEKFKWRKDYDTSWFEEGQLRGRDRKVDYYPYSSYHFVPNGTESQWNPSVEYSVMERYAEGLATYITINERNTFLFVRNLTNRLVLTLPQDRHELGQTKFHIALKAIEPPLPEINGRAAYGMIFFRQDQLHIDLFVFFSVFFSCFFLFLAACVVAWKTKQAADVRRARRRHVVEMLHMAQRPFASATILYDREGAFPNQSECSPNSPQRKGRRNKIVNFHSDVRPVAVEPTDDGVAAVATVFIKLPGGLQAPVKLTLGSSLIFLTRVYPANSRAFLRRRNSHALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUB2</accession>
    <name>A0A232EUB2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_008110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002154">
        <property type="protein sequence ID" value="OXU21924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUB2"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU21924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="175" mass="20854" checksum="7C7149BD9C8129BD" modified="2017-10-25" version="1">MNLLLRYGAKFYACRIYCLAREISERRFVNLDDLRTLKIDHPQLYQIFSESKAEWQNLSQTKFMKNITYRDLMENPIDKFLLITFNSIKERRTEWEEKEKFLDEITFELIHTPILEEITVSHVYTRHGFRITIRRRVEECNAVAAVAFRQSVCLASQRVSVQARGPSLFRCTLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUI9</accession>
    <name>A0A232EUI9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002135">
        <property type="protein sequence ID" value="OXU21977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUI9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU21977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="428" mass="49268" checksum="D131F63882C50B19" modified="2017-10-25" version="1">MSTPKTSTNNTELIKLSNKIEKLTKIVDNLQKEVKSMKRNKSYRNEIQHWEINKSKTSTKSENKSKTNPFDRLKFFRENGKTSEKSVTYVDSDKKKDKDRSKGKAKNDQQLGTIKKSDRTDLPITPKKKRSHLTHLNSDDNDVRINKQSDLVCSVKDCSVQTNNDNRELSTQHKISSKNKKEKKSEQLDKEVIKLKSKSKLKSSCDGCAKSKSNSKFSQCAKGCPYLDKRQAIDKETKIENVESKLKEDKIGSNVQTLNNQDYMIDNQHNVKRFKNKKIMVNLIRDSNEESLKNIQDNENLKINCRFIEDVDLSNIRNLKQSSSDIVSSSAHAAERSKEKRNGCNKCSQNYGPKTVLKINKAILAPDPPMIFLSSKDSSKSESRRRKKSLIKKCEQFLKKRKSKQCHSDYQPRTCCSTHHDEFSETFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUW9</accession>
    <name>A0A232EUW9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01002077">
        <property type="protein sequence ID" value="OXU22141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUW9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012624342" description="Saposin B-type domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15318" checksum="2A6CDFF0B2B5FF13" modified="2017-10-25" version="1">MLYFKMSHTRVFIFFACLSLVFISLVKADEQNSGPSSEEENLTVCKVIIRLFYDVQDEQLNTFKDAVDKEIVEKHITCENHEEFCKREEGDIKNKKKSTCRIILANYLCKGPQNLSTMKVIVDKLMKLADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EUX3</accession>
    <name>A0A232EUX3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_004999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01002080">
        <property type="protein sequence ID" value="OXU22138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EUX3"/>
    <dbReference type="STRING" id="543379.A0A232EUX3"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU22138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="167" mass="18567" checksum="97CE7257A2C08108" modified="2017-10-25" version="1">MQPKRIFVTVGTTKFDELIKTVTNNDVLKELNDKGYNELVLQIGKTDIEPDCTPRCGFSHIEAFKLSPSLHEAMESADLIISHAGAGSCLEALELAKPLIVVTNDLLMNNHQLELAEQLYKNGHLYYSNCKDLAGLIKSMDLSKLKPFQGDNSKEIANVIDEIMGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVL0</accession>
    <name>A0A232EVL0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hyccin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_011945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001987">
        <property type="protein sequence ID" value="OXU22378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVL0"/>
    <dbReference type="STRING" id="543379.A0A232EVL0"/>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="456"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU22378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="64538" checksum="420F230A1AD757BC" modified="2017-10-25" version="1">MIEGIINEWLADCAELSTLELATFASTLSQDDEIVQALYLLLEERSKYSQLVETVCNQLFNFYRSRETQLQRFSLQFLPTLIYIYLNSVAHGDIKNCRTVETLLVGVYNLELVDKNGEPKAVSFRLPSLAMMSIYHEPSSLAPASLTESAVRRFEECNTKLVSWGPLKHIETLNAQNRLKVMTALLFVFNQQLGFFKKSAMEQLCKVASKLVTQGFMKPGHHQRTSYGSESSFVPRLLPRIPVSSQFLLEFLHAIYFSMYNNCWYVASQAVEDVHNRACYETYPEVMLATNAIRNSSSSGPTSAQSADGSIGISVTSSNTTATILKSMITNASFRTKKLPVNSIFYLSYCNDVNIIYDYVLNLNICINYCNNMSKFRIIKLAIFTNCLFILDDLDEMLFETGETKSDHVVDGQSTSSAQRTPVHSSTRRRAWLWKNPLHNSFDDTDIAIADRHQLPGIVAPPPSTENSRRESLCSSQSSPNRSSPKRNRGESKSKRDISQGKGKKDLSKDSTKESSGQTSDSRGSAAQRLYRVLEEQALGEAVGRLSGGSSRNKPQNQPMNLCAPGDVSPNNRYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVV5</accession>
    <name>A0A232EVV5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001954">
        <property type="protein sequence ID" value="OXU22466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVV5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="77" mass="8673" checksum="DADB3201A7BBDF72" modified="2017-10-25" version="1">MYRARHFNAGYASWCGGELESQCYQRCGGPPYTCSKGFFSNEQSCVCGNKGNSDDSDPMDVTKTDFYKLHEPSPDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVY0</accession>
    <name>A0A232EVY0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_003601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001940">
        <property type="protein sequence ID" value="OXU22497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVY0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU22497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="112" mass="13486" checksum="92451B70566A19E3" modified="2017-10-25" version="1">MREGIIRFRIEERVDLDHAPVCLIVARSNKHKGYQKKDGKKKKRKEADEKEVLSWREEDIAEFKEKTSNIEGEIKNEDSAQYTWEEIKKVIKDSVKKKKIKIKKWKLGMRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EVZ3</accession>
    <name>A0A232EVZ3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_006377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001936">
        <property type="protein sequence ID" value="OXU22507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EVZ3"/>
    <dbReference type="STRING" id="543379.A0A232EVZ3"/>
    <dbReference type="OrthoDB" id="5873264at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU22507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="144" mass="15306" checksum="DE3D4CA65334F4A1" modified="2017-10-25" version="1">MAMVAPSPSWATRDSSTVLSNICNNSVNNQTESNVSMPPTNLISPAVTEDIACLMSSGSIATSRDLLQQSATPGHQVNQSGNSQTDKSSNIECIVCGDKSSGKHYGQFTCEVYVVSPFRQYSAIYCISKFAGLDNVFVPVMAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EW40</accession>
    <name>A0A232EW40_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_000842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001927">
        <property type="protein sequence ID" value="OXU22536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EW40"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU22536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="67" mass="7881" checksum="99F9086349544B2C" modified="2017-10-25" version="1">MSSEAQEEELEDFHLAYSSEDEAHKQEKKAIKEESCDIEFEAYEYADIVIKLEQCSGHDYIDDKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EX51</accession>
    <name>A0A232EX51_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitogen-activated protein kinase kinase kinase 7</fullName>
            <ecNumber evidence="5">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">TSAR_010281</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">Alberta</strain>
            <tissue evidence="30">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001800">
        <property type="protein sequence ID" value="OXU22888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EX51"/>
    <dbReference type="STRING" id="543379.A0A232EX51"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14058">
        <property type="entry name" value="STKc_TAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000143">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000152">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="17 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="27" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="21" id="KW-0346">Stress response</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="20" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="288"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="OXU22888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="533" mass="60545" checksum="3FAED2F5A1FBEAA8" modified="2017-10-25" version="1">MANSSFMQRFVEEIDYEEIETEEIVGKGSFGVVWKGKWKGQSVAIKHINSEGEKKAFAVEVRQLSRVVHSNIVKLYGACTKNPVCLVMEYAEGGSLYNVLHSNLQLSYTAGHAISWGLQCARGVAYLHNMQPKPLIHRDLKPPNLLLISGGQTLKICDFGTACDLNTYMTNNKGSAAWMAPEVFEGSSYTEKCDVFSWGVILWETLSRRKPFDDIGGSAYRIMWAVHVGQRPSLLENCPPIIEDLIVNCWSKVPDQRPSMNEVVDIMSDLLEFFSGHLKPIDYSHTNEMNKANKSESNGSSIDSTMKSNLDSSMDYDSYNSLRFNDNNTEKNEQPNLKPVSKPNYYNILDQSKASKNVDNANSDKPSLVKVPRPLKQRIEPQPVINFDKNNSKMPPKILVNNQSFNPLIPNMPRLEFMLQNTNAENLEMVCNLIDQDLRPIMPNDSCTMSINIFKEHFLLTEEYFKVQNEISLFSHHKGKMLSNLSANNVLFQEVIEKLEDEKESLIKLYKNLKRQLEIMKLRKTNTIPVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXF0</accession>
    <name>A0A232EXF0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_014010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001729">
        <property type="protein sequence ID" value="OXU23106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXF0"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000003">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF26">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 41 MEMBER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="198"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="410"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU23106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="566" mass="60712" checksum="2B4CDA4A8A1EBE75" modified="2017-10-25" version="1">MVGFPALANESTPGVPSDSQEPVQRSGNMSPGKNDGIVLTLNGLDDKSAERTKLDLPTAESIRAEPAIVKKIAAGLKSCGATNGNPVGKEASSGKRPEMGSLSSGSSIVTICSVTNSEPDPDYPTGGGIGGGDGGEDPPIKKKKRRPLITEETWYNTGLQISVPFFIAGMGTIGAGLVLAMVKDWEVFEEVSQIFILVPALLGLKGNLDMCLASRLSTQANLGNMKGYREIIKMIIGNLALVQVQAIVAATLVAVFATAVGAIMDGKFSWEHSLLMMASSICTATSSCFILDFAMIAVIMGAHRSRMNPDNLATPLAASIGDIVSISVLSAIASALYKRLDHEIWILYSIIAVFVILLPIWICIVLKNKYTKHVLTSGWTPVISALFISGLGGLILDQAVDRLQGFVIFQPIINGIGGNLVSVQASRISTMLHQSTLIGILPPWTKTWVSPWKALFHGEPSAKTARLLISMSIPGHIAFSFAADYIRWGKSTIHIYFVLSYLTVAVLQVMLLLYVAHIMIHVMWKYKIDPDNSAIPYLTALGDLSGSLLLAAAFIFLKEINHEYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EXM8</accession>
    <name>A0A232EXM8_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001724">
        <property type="protein sequence ID" value="OXU23112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EXM8"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="56" mass="6627" checksum="BCA7A362DB5D036E" modified="2017-10-25" version="1">MKIRAKIVNHVNENWEYFEPFTVGDKSLKIIIAFVRVYSGEFQGVKIKDKYDIGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EY89</accession>
    <name>A0A232EY89_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_012842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001703">
        <property type="protein sequence ID" value="OXU23178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EY89"/>
    <dbReference type="STRING" id="543379.A0A232EY89"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU23178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="132" mass="15417" checksum="A8E78DCCA3CC8A5D" modified="2017-10-25" version="1">MAHTHTHTRFCAENNDKLIEYLYRHTRQKIKVLLNLQLLWKLCAWWIAKIMSAVPIHGMIFEILAEKLSTAKNVLCIRYNTGYVSSCMASMMGPRGTVFHIESIPDLKEKVKKTIKKTNPYLLLNKRIQLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EYI1</accession>
    <name>A0A232EYI1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001621">
        <property type="protein sequence ID" value="OXU23405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EYI1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU23405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="215" mass="24605" checksum="620FE3FCD52E850D" modified="2017-10-25" version="1">MSRSNIGNASSDLPPSYDEVCSTTERRSSSPSTSRKTKSTSKSKNNKTAAEFFPTAPPRDILENTQVPEPTRLEDTSIPINVGIDDIDSHLRTITTRNNTYQQIPQRLEPQNDARLHQRLHRNISYNGIDDGKLAKYIVYTIAGVFAVFFIIVILNNMPSSSYTNYLESEEHLKYKKEMDRLFEGNDYLSGRRDMKKDGEEFSAKLRNTTFLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ31</accession>
    <name>A0A232EZ31_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase assembly protein COX15 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_006212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001527">
        <property type="protein sequence ID" value="OXU23674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ31"/>
    <dbReference type="STRING" id="543379.A0A232EZ31"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU23674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29914" checksum="5FC9959C3ADE0F52" modified="2017-10-25" version="1">MVSWTLFGEKVPTTEVSWLDEFKNYKQFPEYQISNKNMTLEEFKRIWWMEYAHRMWGRLIGLVFIVPAVYFWFNNMLNPVTKKRILILGTLIGCQGLMGWYMVKSGLENRFDGPTDVPRVSQYRLAAHLGLAFFIYSGLLYTTLDQLMPVRSNTNNYNTSELKPTIKYNNRFRILAFSSKGLIFLTALSGAFVAGLDAGLIYNTFPKMCNKWIPDDILFMSPLYKNLTENPTTVQFNHRTLMWSRSDDTEDNHDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EZ92</accession>
    <name>A0A232EZ92_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001554">
        <property type="protein sequence ID" value="OXU23617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EZ92"/>
    <dbReference type="STRING" id="543379.A0A232EZ92"/>
    <dbReference type="OrthoDB" id="18585at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF67">
        <property type="entry name" value="RE68569P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU23617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="60272" checksum="9A11A33D7EE52D44" modified="2017-10-25" version="1">MTIGLLGLVTGCVVLVLQPYEFIFKWKATFGEGGEIYEIWRAPPVDLYLKVYLFNITNHEAYMNREETKLKFDQIGPYVYKEYLEHGNVTFNDNGTVTAVPLHPLKFMPELSNGTEEDIVVMPNIALLSIANVMKDASYITRWGLNLLIRQTDSKPLVHMTAKEFMFGYESTLVTLGNNVMPAWIKFDRLGLIDRMYDFEGDYETVYTGETDPRLTGLIEKYNGNENLPQWSGKCANVKGSSDGAKFQSYIEPNDTLRFFRKSLCRSEAMVRTGEKYVKGLYSYKYKFMDHELDNGHFNPENKCFCRQGMCLPYGLIDVTDCYYGFPIALSYPHFYDSDPSLLEAVEGLSPVQELHESYFYIQPKSGLPVDLAFRFQINMALQDISAIEHVDGFSDLVLPLLWFEIGMHELPDNLNNKFFLYLNVLPAMQEVAIYGLFLAGAISLVWSVVKILTYKPKSSGMTSQWLDAEMQRKRLNYLNERRPSLKAKEMDVYFNALLTTKEEEIEPIEPSALEELPNLKEDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0J8</accession>
    <name>A0A232F0J8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">c-SKI SMAD4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_004868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001401">
        <property type="protein sequence ID" value="OXU24100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0J8"/>
    <dbReference type="STRING" id="543379.A0A232F0J8"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF26">
        <property type="entry name" value="CORL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU24100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="190" mass="21311" checksum="EE45C2F9E2E204BB" modified="2017-10-25" version="1">MLRRLPEDFAFLVHHECTYGCKGAFVPSRYNSSRAKCIKCSICGLFFSPNKFIFHSHQTGSSDKYVQPDAANFNSWRRHMKLSGEPPDEIVHAWEDVKAMFNGGTRKRIIASASHSSSLNVMKKHIKFSNNASMPSLSAHNAIAESSIESVPNQQRVPPFTDTALPICNTNVIDYMWQHQQQVAVATAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F0T5</accession>
    <name>A0A232F0T5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_016178</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001333">
        <property type="protein sequence ID" value="OXU24325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F0T5"/>
    <dbReference type="STRING" id="543379.A0A232F0T5"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06382">
        <property type="entry name" value="PBP1_iGluR_Kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000117">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="15">
        <location>
            <begin position="449"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="16">
        <location>
            <begin position="459"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU24325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="64602" checksum="445C8BF0BD85B15A" modified="2017-10-25" version="1" fragment="single">MMSKVPEWSTGEWLTSVLLGFNSRFDLPTIKPLRAIFTEDQKDSPSELAFKYAVYKINKEKILLPNTTVVYDIQYVPKDDSFRTSKKACKQLSRSVQGIFGPADPLLGAHIQSICEALDVPHLEARVDFEPSFKEFSINLYPSQDHLNRAFRDLMSFLNWTKVAIIYEEDYEINFFIWNMELAVVIEGAFSTAVAGLFKLQDLVKSPPSPKTEMYIRQAGPGSYRQVLREIRHKEIYKLIIDTDPMYMPQFFRAILQLQMNDYRYHYMFTSFDIETFDLEDFKYNSVNMTAFRLVDTEEPSVAETLRQMERFQPVGHAILNRSGIIQAEPALVYDSVQVFAHGLAALDRSHILRPANLSCEREEPWDDGLSLYNYINSVTQSQVDELQAGLQGLTGHIEFNEGKRTNFKLDLLKLKKEELVKVGEWKLGSGVNISDVGAFYETTATNITLVVMTREEKPYVMVREDKNLTGNARFEGFCIDLLKWIAGQVGFQYAIRLVPDHMYGVYDPETKEWNGIVRELMEKRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1H8</accession>
    <name>A0A232F1H8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_003263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001262">
        <property type="protein sequence ID" value="OXU24575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F1H8"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000065">
        <property type="entry name" value="Programmed cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="99"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="195"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="449"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="532"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="815"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1352"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU24575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1428" mass="159605" checksum="A2A1CBDE05DF0B83" modified="2017-10-25" version="1">MHVCRLDVGETEVCLRSGEENKRVNFDILKKKLNYKNFPRGGKKPVIKPSNNLFSKRTKIKAKKLRSKPNKTKEEASTDDGPLVANTAQNLRLSSLHEGMVIVGRIFRVTDYHAFLSLPGQISAKLQATDISDSYTNSLKSIAKNEEISEEFKPMSDLYKEGDYVVCYVKSFNPNTKKVSVSLEPQLINQSLNPGTLVKRSKVVLSISSVEDHGYVLETGLKNFRAFLSIKDIADEETKLFVGKQIICAVKDVKTAENTYTAKVSIKTKHLDTVETNITSLDSLIPTAQFPLTVKKVLKNGLQVEFGENSIGYINQLYLQNSLDSFEKGQELVGTLLYIVPTMKFGYFSLLPQEVEQKLLAIGDVITKAKFVSKDSRGIILQLKKGVRGYVPLKRTEVQFEKIDSVFTKNSIHKCKILAYDSIARVYICSMEKKVIEKTVVNKTILQPGHVVEVKITKIKKNGYISVSSGTRNGFVPADQVSDPGSKATFKVGQNVTARVLETSVKNIFTLKKSLIESKLPILCKMEDAKADAVHDGTVSRITDAGILIRFFDGVKGFIPKKFLNNNTASAKWNMVVGQTVSTIIKDVDVRENKLILSLVKGAKAQNTKFKIGDVVEGIVTDSSAEGVQLRLKSDGEEAPTAYLPAGHMSPCYEVGKLLASKTVAGESVTAIVFSTMPTLILSTTFAPEKTYKIHDLKPEDTVMCSVKKIHKESVKVLMPLVKSSKFGTVPAASAGNIESMYENQILIGKVTRIEKDSQEISLTTQLSKVWKSVSEHDVKMMTAVDVLSSYLNKVTELSRNVYYTSKPISKLSIGQRIKGSVESVMDHGLILKLENNVKGIVRTSHFTGNVVPGQEVEGSVLWINYPHEYVELTLIRSIMNGISIKQNKLAKIPVGVQLRGEIVLITDWFVLVVLKGQGKGTLVTLPSRRHLNDIVPDLTPYQIRDKVRCFGVLNGEDADILLPICMLKSSFEIHIPRELEKPQKRKLEAQNGNEKVSVAKKSKNLNVNEEIKEEKSEGKQVKKETAEPAKPAERKKVKAQLIDGKKPNKRKRSEPVIKSAESSGDDEVSDEEVEPAAKAANTKPTQTLAIPECGFQWDNSTTGQVAQDSSSSSEDEEQTEDSSKPKKKKLTPAERREQERLKEREIREREEALASCQVPQTVDQFDRLVLSSPDSSLVWMQYMAYHLQATEIEKARAVARRALKTINFREEDERLNVWQAWLNLESRFGTAESLNEVFQEAVKTNDAQKVYTHMLTVHGDAGRQADLEKLTSAMIAKFKQNPETWISCGTALLKIGMKDKSRHIMQRALQSLPATKHVDLLVRFAQLENRLGDKERAQTLFEQVLTSYPKRTDVWSSYVDSLIKSGDIEIARKVLDRAITQGLPPKKMKVLFKKYIDFESKHGTPENVSRIQELAVKYVEEQCKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F1W1</accession>
    <name>A0A232F1W1_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_010107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001302">
        <property type="protein sequence ID" value="OXU24427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F1W1"/>
    <dbReference type="STRING" id="543379.A0A232F1W1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07567">
        <property type="entry name" value="biotinidase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012101">
        <property type="entry name" value="Biotinidase-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012986007" description="CN hydrolase domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU24427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="579" mass="64600" checksum="9098FD6BD40FF2FA" modified="2017-10-25" version="1">MLSNLFHYFVIVILAFCKYSSQASTVDSPTYTAAVVEYFPIVAGIDGKEIAEANSNNYLTIIKTASTYNVDIIVFPEFGLSSLPKDGNREKIFNATGYRNYYRDVASYVPHPEEAVVLCNASSKYAKSLQKISCAARDSKLYVVVNHQEKVDCEPNSSADCAPDGFLLYNTNIVFDREGRVVARYRKFNPFNEFGTNVTVEPEHSSFQTDFGVTFGQFICFDLLHQKPSIYFVNNPDVKDVIFSTHWFDYPPFLEATEIQAAWAYAADVNFLASGYSDAITASGGSGIYGGKMGPIVTYHPMKTSNALVIGEVLKYHHREKQVENLKKPIVYEFNHAEVPTITGIPPRVNLSQNFKDGLLLYTSELLDVEKSSVHVTTLCDRDICCDFHVETSFDKKVAAKRDAVHYKYRIVAFNGVTTYGNMSTSGLEVCALVTCAGDSLENCGDYYDDSTNVVMPTRLDSVIITRRVNLDEPVLFFPTTLLLQTYEPLGSSDFAYLTSGPSESSLMVMHLIKPQTRLATFGIYGRRFDRDGEPLTMPSKAVELNISFMALVGLLAVFVVVGCWGYPRKTMVIRNKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F250</accession>
    <name>A0A232F250_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="12">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_010639</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="12"/>
    <dbReference type="EMBL" id="NNAY01001170">
        <property type="protein sequence ID" value="OXU24896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F250"/>
    <dbReference type="STRING" id="543379.A0A232F250"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU24896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="168" mass="18822" checksum="04200EA1C1DCF0C1" modified="2017-10-25" version="1">MGISSTLRSIIIGVPVGFLFFNQVGYVARVEGVSMQPALNPDLEQEDYVFLNRWVVRDKNIRRGDIVTFKSPKFPNQKLIKRVIGLSGDVIHTIGYRKQILQVPDEQCWVEGDHTGHSMDSNTFGPIPLDIITAKATCIVWPPSRWQNLDNFVPDDRTPLNSSSALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F2S2</accession>
    <name>A0A232F2S2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_008344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001132">
        <property type="protein sequence ID" value="OXU25031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F2S2"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012759827" description="TIL domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="6">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="82" mass="9142" checksum="75288778AF5AA236" modified="2017-10-25" version="1">MSKLTVLCLLVLCISGCVITIDAASFICRKPNQEWTECGSACPRTCNQLKDRLCTQQCIRGCRCNRGYILNNNGECVLLKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F367</accession>
    <name>A0A232F367_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TSAR_002713</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Alberta</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001104">
        <property type="protein sequence ID" value="OXU25115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F367"/>
    <dbReference type="OrthoDB" id="512616at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15669">
        <property type="entry name" value="ePHD_PHF7_G2E3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15496">
        <property type="entry name" value="PHD_PHF7_G2E3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051188">
        <property type="entry name" value="PHD-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059102">
        <property type="entry name" value="PHD_PHF7/G2E3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042013">
        <property type="entry name" value="PHF7/G2E3_ePHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420:SF42">
        <property type="entry name" value="G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12420">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26054">
        <property type="entry name" value="PHD_G2E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="212"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="348"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="803"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="890"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1130"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OXU25115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1357" mass="151236" checksum="59392A036E68457C" modified="2017-10-25" version="1">MPAVARIEDDNNKNNVSSKMTNEKLDSYNRCSNPFRIPQHFKMSGLRNVPRLIRERLAHVHFGAKICCSCRHRVYAMLKERKQLKPSVRLRNSCNLDRRRSEQTKSQPQPSQQQRRSEPAVPVAAASAVKQVTMTVTASSEADKRAIESLFNEDEQDIAGSSGASCAVSNLEVESSALLVHAMSRRSRPQPQQQQQQQQLSLAEPEKEGPVKQICCFCGLTEDNEVEFGKFYQHRGIVTHYYCLLLSSNMEQKGNDDEGILGFLADDIQKEIRRGKRLVCSYCKKNGATLGCCNAKCKRIFHFPCGLKAGSLHQFFGEFRSYCINHRPKQKIDDRVKKEIENMKNILCYICYEDVAPLDSNGTLWAPCCKKNAWFHRKCVQQLAMSAGYFFKCPLCNNKREFQTAMLEYGIYIPRQDASWELVPNAFQELLYRHDHCDAAACLCPKGRTYTSSNAKWELILCRMCGSQGTHIFCGGLKWVSPVWECQECISITKKSTENIVTTDDSTTRSNDIPIQRETTLNVTIRESDEDSDSDISVGNESIPLETNLTNIPAILPEVKLRPGPRSFKMQQVQKLQSSNAYNEIVNQTNNSLNHSNTTVNNAASNSVGIATLSAVSAKVNNDVICIDSDDEAIEIVCENVTKRHRHQSELICASTSNSSNFSNRMNCVSPKVSNVLPEEIDDSPFNIIISNVTSLAPEFFASVPELTEEEEIEQVDCDLPIQVPDTPSTNGLKRSHPTDEEIEVLIVDEAPKRARLEINTTIDHNVVNSLPEKVTSVIQNDESSSSRISGQNSVEPELLSNVKDNPSKTETQALPSTGSADEASSAHDNCHRDAGTGPAILNTDGQSHEEEAATAADTQDELPDSPQSADTKCPVDRPELAIRTVLENGSSSHCSSSGGSGGSSKSRFSSGDRSGLIPDFVRLSDLKFRVCGSDVELSYRTCRIQVKMNGLQSSNSTTLNDASSAATALVSSFAGSNQHLSSEKSSKSYQLLLSDDSTDESDRIHRSLRTRSLRSFVYEDDNTLLEYPTSANDALNNAKKSLTVTEKRLTRSDWKENWDPEVSSSSNNDFDSAIISNKPARDLKDGGINNREISSKTEEHSLSQSQKEEPSNTQRLLRRSNRIVRHFRSVQQSELNDQINGDSTDSNTTTFSPSFGKSNQMASGDRTTRSSRSLKVLNGSSDVTVQQDSKKHLKNVDIDELKFTLTNKINGAHNNNDVHMDADFKVSIDLQKISNLISAKPDLFFKTKNNGVRRLRVYSVDEKLKVEFKSGETKFLTKSQSFDCLLDVANDGFSHIMGKSRSLDCLSNIDSHNLMPLTDLKDCMEIKTRRSQRRKARQFEKHECVRNGICISASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F3L7</accession>
    <name>A0A232F3L7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_015580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001049">
        <property type="protein sequence ID" value="OXU25341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F3L7"/>
    <dbReference type="STRING" id="543379.A0A232F3L7"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000891">
        <property type="entry name" value="ATP-binding cassette sub-family G member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF6">
        <property type="entry name" value="PROTEIN WHITE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="49"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU25341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="698" mass="78284" checksum="D5A9FECB32E3DE14" modified="2017-10-25" version="1">MKLEGSSSLENDGNGILLQSRRSSEVRVQIIQAKPKTITHLPKRPPVDLAFSDLTYKVREGRKSNVKTILKSVSGRLRSGELTAIMGPSGAGKSTLLNILTGYKTTGMQGSITMNGRERNLSAFRKLSCYIMQDNQLHGNLTVQEAMKVAANLKLGRNVREAEKEEVIQEILETLGLAEHRKTMTSNLSGGQKKRLSIALELVNNPPIMFFDEPTSGLDSSSCFQCISLLKTLARGGRTIICTIHQPSARLFEMFDALYTLAEGQCVYQGSTSQLVPFLSSLGLNCPSYHNPASFIIEVSCGEYGDNIKNLVNAIRNGKHDIRDGYAFPEKEVLNNSSVKNSDATSDGTSAKDKNDVNNIEDKFCESKINEKSNGGMISSYAKNDIVKQSEIALLMDDKKDNVTTSLLDSTLVTTPERYPTSELVQFWIVLKRTLLFSRRDWTLMYLRLFAHILVGFLIGALYYDIGNDATKVLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLKESFNRWYSLKSYYLAITVSDIPFQAIFCILYVTIVYFLTSQPAELSRFSMFLGTCLLISFVAQSVGLVVGAAMNVQNGVFLAPVMSVPFLLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYSFGREKLSCKQEYCHFKKPQQTLEELDMNHADFKLDVLALLLIFLVLRIAAYLFLRWKLKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F478</accession>
    <name>A0A232F478_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TSAR_016373</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Alberta</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01001064">
        <property type="protein sequence ID" value="OXU25270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F478"/>
    <dbReference type="STRING" id="543379.A0A232F478"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF337">
        <property type="entry name" value="GATA-BINDING FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="89"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="183"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OXU25270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="308" mass="33925" checksum="5DD1975B1ADC1FE2" modified="2017-10-25" version="1">MSSWRAYDSAGFQRASPYDTAMDFQFSEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKINGMNRPLIKPTKRLQMGQISEFQTATRRLGLCCTNCGTRTTTLWRRNNEGEPVCNACGLYFKLHGVNRPLAMRKDGIQTRKRKPKKTPEPNARQNPGEHDNSTSTASSPSNELKSSHHQQHQPPHQQPHQQQPQQHQLDNKSSSTNPSSSSSDRPVYLGHTSLLSSSGGSTSAAGSSSLTTVKTEPRSCDTGVIGQPYSAYYQHPHQLAAPTSEHQQANYYAAAAQEAPYHHQHHVTAAAKILASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F4D0</accession>
    <name>A0A232F4D0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">P-type phospholipid transporter</fullName>
            <ecNumber evidence="5">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">TSAR_000334</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Alberta</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 26">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="5"/>
    <dbReference type="EMBL" id="NNAY01001002">
        <property type="protein sequence ID" value="OXU25535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F4D0"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000054">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000130">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF218">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1085"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1147"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1186"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1269"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1366"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="973"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1650"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1692"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1790"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1666"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1712"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1796"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1833"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="17">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="721"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="802"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="927"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="947"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="950"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OXU25535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1901" mass="213254" checksum="DF208C54C1856F79" modified="2017-10-25" version="1">MFYKQRLYFKAVVTYSWRVSKNRSLKKGLKPVDKSTTSTPLYTIIYTIRRVRTTKYTTLSFLPRNLLEQFHRVANLYFIFIVLLNWVPAINAFGKEVAMIPVVFVLGVTALKDFFEDRRRLASDRRVNNFTCRVYARDGDRYVKTAWKDIKVGDLVHLSNNELVPADVLLLRSSDPQGFAYLDTCNLDGETNLKQRQVVKGFLDIQSSFQPAKFRSIIEVDKPSTKIYRFHGAVVHPNGARVPVSTENLLLRECLLKNTDFVEGIVVYVGHETKAMLNNGGPRYKRSRLERQMNLDVVWCVVILVVLCIVGAAGCRFWLSAYTSVGPVLFLPVIQDPSYEGMLTFWTFVIILQVMIPLSLYVTIEMAKLGQVYHISCDSELYDPETDRTAECRALNITEELGQVQYVFSDKTGTLTENKMIFRRCAVGGQDYAHTGEGENLVPCIRLKEDLLIGTCRHRLQEFLILLAICNTVVVNTHPHHDNMNSSGVIEEPQNNGAADPTRYVRLTESRSVTPAPPERTSPALPHSSTITPPNSEEIFSSVASMEITESDESSVLRSKISRPKLLNLPTMTNLSMLTKRLSPLGMRNNSSSVPERNGRSLLETPSTPAIYEAESPDELALVHAARAYNVRLTRRTAQSAIVSLPDKSSLAFEILKTLPFDSNRKCMSIVVRHPHTGEIVLYCKGADSAILSALNANEEDSTITTKVRQQLHSYARQGLRTLVMARRSLTAQEFELWTQKHAEIEACHENRERRLRESYTSLESHLTLLGATGIEDKLQAGVPEAMASLVSAGIVVWVLTGDKPETAVNIAYSACLFTPAMQLLRLQARSKSVAESLIHGHLEAIQRENAANAAAAAGESIPHELDPAERLAYRIGSPWQRQRALVVDGKTLTFILDPRSGLTGPFLDLTRACSSVLACRATPLQKAYIVRVVKEQLRMRTLAIGDGANDVSMIQTADVGIGVSGREGTQAVMAADFSIARFPMLTRLLFVHGHWCYDRLSRMILYFFYKNATFVFLIFWYQLYCGFSGTVMIDQIYLMLYNLIFTSLPPLILGVYDQIAPASLLMESPRLYERGRLASVYQPHSFWVTMADALYQSIIIFFLTEAIYHDSDVDIWEFGTTITSICIVVMLLHISVETRSWTLMHVAGMVCSVGAFFGFALIYNAVCVNCMGLLCSYWVMEVAIGRYIFWLTIIITSVLAILPRLIYRVVKSTIAPDIIQRANVAYMEKNGRFTNRRGVGSGESGLVAGWSRSTQNATIRWKASVYKLIWTDMLLFLTIYYALSGLYRLALDEDQKRVFEKVVEFCRKHTSSSPLSFVLGFYVTIVMNRWWNQYITIPWPDSIAVFVSATIHGNDERGRLMRRTIVRYVCVCLTLVLASVSPRVKKRFPTMEHYVPAGLLLENELLIFQSLNSKFPKPSKHWLPIVWASSIVTRARKEGRIRDDFAVKTLIDELNKFRGSCGGLVHYDTISIPLVYTQVVTIAVYTYFLTNVIGQQWILEEPKTVDIYFPVFTTLEMFFYMGWLKVAETLINPFGEDDDDFEVNWIVDRNLQVSYLIVDEMHHEHPELIRDQYWDEVFPTELPYTAASEPFREEHPEPSTAGIQLSAAQQELQPSSVRIDEMEKEYQQKYNDMNDDAISGIHFVASGGKLSRSGSRVSNRDRAISTGSTPSNIGGSLTRINSVTNVLKRIFSKEDRPDGNNSGAKTPGRLPNSTSSASLRAQSGPGGSMRIGVIEEVDEQMTMTSMRPENRPHVQSIFPQGPPPASAPVDVPGSSMAHNGDIFSTSAPVPALSGSADSADTTTGANAARYRGTRTQMSVPVGHGGFDSAGFSRDPNSSTRSSSNCSLDDEFSKLKIEREKQRVEKALQKLSRSQALLDVTYTHQIATTKISVGEMPSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F522</accession>
    <name>A0A232F522_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Syntaxin 6/10/61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_005831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000997">
        <property type="protein sequence ID" value="OXU25563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F522"/>
    <dbReference type="STRING" id="543379.A0A232F522"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21443">
        <property type="entry name" value="SNARE_NTD_STX6_STX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Syntaxin 6/10/61 N-terminal" evidence="4">
        <location>
            <begin position="43"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU25563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="296" mass="33564" checksum="B36D6B8281CB74FE" modified="2017-10-25" version="1">MQPALGVRHTHISRQKCKHVGRPIEPPMLLLGDHLCVVEERPREVFKALNKTRGLYARWQDLQAQQATSGPNSVVATPTLAAGLPMLTCREELEWTKKNPNKFKLDNKELTLRRNFVEQTGEEVKVMKDKLNISKVRDRDRTARQPTLDNSPAKAPTVSHGTAKYSKLENEMDSPNRQFLPKPICNQNSMRRHQEDIMSDNTGTLKTVSRQINSEYDEHQVMLDDFNNEMEVITDSKLDATMKKMAKVLHMSNGNYNNYIPAPTTSTSSTSDYTPKPSSLCSLSTTITNCFLCSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F536</accession>
    <name>A0A232F536_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_001263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000991">
        <property type="protein sequence ID" value="OXU25590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F536"/>
    <dbReference type="SMR" id="A0A232F536"/>
    <dbReference type="STRING" id="543379.A0A232F536"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="65"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU25590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="260" mass="30082" checksum="F79E4115B06776F1" modified="2017-10-25" version="1">MGYDIKWIIPKLRSTTSLWNFASSITFAAVGIFSKIIMEWLNKTTVYNKHIIERALNSRPKEVPLITVSNHHSCFDDPGIWSTLDLKYLLSRRKMRWSLAAHDICFTNVWHSYFFMLGKCVPVVRGNGVYQEAIDFCIEKLAKGDWVHVFPEGKVNMLKENLRFKWGIGRLIFESPVVPLVVPIVHLGMDQVLPNEPPYMLKTKKKVTLYYGEPIDFSEMLADLRKSNADEVEARKAITDRIQDELLRLKTATEELHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5C6</accession>
    <name>A0A232F5C6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_006866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shroom family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000968">
        <property type="protein sequence ID" value="OXU25678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5C6"/>
    <dbReference type="STRING" id="543379.A0A232F5C6"/>
    <dbReference type="OrthoDB" id="10063560at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014799">
        <property type="entry name" value="ASD2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027685">
        <property type="entry name" value="Shroom_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012:SF32">
        <property type="entry name" value="PROTEIN SHROOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08687">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51307">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASD2" evidence="6">
        <location>
            <begin position="416"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU25678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="747" mass="83495" checksum="608BDFCD8F6385D4" modified="2017-10-25" version="1">MYSITTLCFRRSANPTCLFFRVRRSQSKASYLAYRRERGAPDSEGSYKRTMSPNARLDDPVLLLKVTPHHQQSLINNNNNNNNNDVVVSPTNNNQNHNNINNNNNQYQRHPRHELAKSQSSDALQQHHNHHRLEDHFSRKSLHNVNSAESNEANNKTSRDSSQAEENGCLRRSEKRDRLSPQSVEVLNDRNRQLERERRKLAASCEPQSRLVEDFYRESAVTTIEMTSQNVEMLNRRNVAEKQRAQTAEARSPLAGSPKFVEFPSRTTPPTVTTGTTTNPFDSLTDRKVSSPTQTDQSWDRKSRSSTSSSSAPSSPTRTSPTEKSSSSSSKRASPCVSPQPGVIEGLTLIQRTEVVLRVNAPTNDVASQTEEPATLLGVTPAAEKEVERLRPEEETESLAKPRKKLQEEIECEELSRDLANQLGPDDKLLPILVPIPEHKKSTDYVVDLFRVEAALHPRPRPRLTINEESTSIDAADNESEDDKKIDSIPSTPVTPSAPDSSSSSSSSSSPLSASSVYFTTSESKARFLTRYSQDVVAEQVTTTPATPSIKPTTPDSLDLRQKKEELMIRLDKKLVVLRAEQEAVREEGEVNEALGSRVQARIAALAKPAEASKYRLHVEEVGKITSLLLGLSGRLARAENALYGMPADHPERNAQLFPSNSQKILESKRDKLMDQLEEAKILKGNIDRRSVNVSAILSKYLSDEEFADYQHFINMKAKLIVDGREIQDKVKLGEEQLAALKEAIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5P3</accession>
    <name>A0A232F5P3_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_009173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000904">
        <property type="protein sequence ID" value="OXU25995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5P3"/>
    <dbReference type="STRING" id="543379.A0A232F5P3"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011991538" description="Carboxylesterase type B domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU25995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="582" mass="65102" checksum="EDC4C20D22D1D972" modified="2017-10-25" version="1">MLLFTGLFHNIVLLSGSALSPWASVHDPNDLRVQVAKQLDCRHENDEDIAECLRAVSLEALLDVELNEIKFMPSIGPSVPVDGSHPDPGLDMERLSDAFIKVPLILGVSTAESYLDFNANDIQYGFEEDQRNRVLRTFIRNAYVYHLNEIFSAVRNEYTDWDKPVLHPINIRESTMEALSDGHTVAPLMRIAFYHARRGASTYFFHFNYQTKDSDYPQRLGSVRGEAIPYILGLPLISGGRFFPQNYSRADQGVAEAVLTFFTNFAKTGNPNEPHNIESVDYGTIKEKTRYRGLTWEKYETGTQQYLTIALKPKMKNHYRGHKMAVWLNLIPQLHQPGDDVSMRHHHFREKGDLFYAGPVRDEWYTPLPLPGTTRTSSSSTTACATTSNADEESALAAAGTQNINAIIDESKDDAELLQRLASRHYYSTTTALAITVGVGCILLVLNMLIFAGIYYQRDRDKKRAAMACASNNGQESLAMSSRSPTKPQENNPRSSQEPPPSYTTLPKSPSSIQDHMQDSCLQDQLDRNRLKTATLTRSGSGQKDHPMPPRPPQRTSSSLSTVAGSTSGSVKKRVQIQEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F5P9</accession>
    <name>A0A232F5P9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dynamin-like GTPase OPA1, mitochondrial</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">TSAR_016962</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Alberta</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="NNAY01000869">
        <property type="protein sequence ID" value="OXU26134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F5P9"/>
    <dbReference type="STRING" id="543379.A0A232F5P9"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000171">
        <property type="entry name" value="Dynamin-like 120 kDa protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045817">
        <property type="entry name" value="OPA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF67">
        <property type="entry name" value="DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19434">
        <property type="entry name" value="OPA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="302"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="913"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OXU26134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="977" mass="113331" checksum="74AA41D6A844AD07" modified="2017-10-25" version="1">MKQILCGKFGCSVLLVSKTSRYPLSIVGTRYLTSGKFRYCKPLLASPQARILVNSHRKYVMVVTKILRGALKIRYLLLGGAVGGGVTLQKKYEQWKEGLPDMSWMNGLIPNDQQWKDFRGSLMTIKDTLADKVEIDPRIKELGEAKYREYRKWFNERLDDAIKAAESRKIEDSPNNQNSNSSNREIEVITAFANQVYSDVKDEITKNTVAFALPATAEDEDRRKSQSSQQRIDAMHDEVMQIQSKYQRELERLERENKELRKQMLLRGNFKQNNRKIKKSLIDMYSDVLDELNDYDSAYSTADHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGGGEMMTRAPVKVTLSEGPYHIAQFKDSTREFDLTKESELAELRREVELRMKNSVRNGKTVSQDVIAMTVKGPGLPRMVLVDLPGIISTQTTEMAEDTRDAIRQMTQQYMSNPNAIILCIQDGSVDAERSNVTDLVSQMDPAGKRTIFVLTKVDVAEQNMTNPERLKKILSGKLFPMKALGYFAVVTGRGRQEDSIQTIKDYEEKFFRSSKLFKDGLAMSGQVTTRNLSLAVAECFWKMVRETVEQQADAFKATRFNLETEWKNNFPRLRELDRDELFEKARGEILDEIVNLSQVSPRHWEEVLMDRLWDKVSMHVFENIYLPAAQTGNPGTFNTTVDIKLRHWAEQQLPSKSVEAGWECLQQEFQKFMMQARLSPDHDNIFDNLKNAVVEEAITRHTWEDKASEMLRVIQLNTLEDRSVSDKRDWDQAVRFLETSVKEKLQATEQILKDMLGPGRKERWLYWQSQTEEQQKRNSVKSELDKILYADKKHAPTLTQDELTTVRKNLQRSGLEVDNEFIRETWHPVYRRFFLQQSLSRAYDCRKGYFLYHTGHDAEMECNDVVLFWRIQQMLKVTANALRQQIMNREARRLDKEIKEVLEDYSQDNEVKQKLLTGRRVTLAEELKRVRQIQEKLEEFIQALNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F652</accession>
    <name>A0A232F652_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_001731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000913">
        <property type="protein sequence ID" value="OXU25953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F652"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU25953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="65507" checksum="9ABFA96E014D19D0" modified="2017-10-25" version="1">MPPEGNAEFGKDRLTIGTEQKRYLITYMQTHSFFARRQIPKLSPNGHQKFKNMWKQLTLKSNEIGPAIKDEAQWIKAKGKVNAFFKIYNKTGNNKPEGEVPEQDLQIANIFGKYGTGMAVTQELGFMHIQTKKSKTVEHISKELAGFNNHYDLKSNVRPTNLQPHFLVQSMTRYYSSNTFKFMSCVNFMKTIIQEINNRGKPKDEVSWVRSNPSNENFTGPFSSVTANYKATSKEANPNYSPASITTPVFKEQPNPSNDNFTAPLSSVASNNKPTSKEANSNYLPASITVSDFTETKLNRNNKPKGEVPEQDLQIVNIFGKHGTGMAVTHELGFMHIQTKKSKTAEDISKELAGFNNHYDLQYHDVISNKENNVNAINFTTKTDNPTSNEHSNPLNENFTGPSSVTANYRATSMEANPNYSPASITTPVFNEHLTHQMTISLDLFLQLHQMTNQHQRKLIIIIRQHPLQHLILQKPNLIINYLYPFYNVYLNVHTQALNINVPTSTDVSSCEQSSKQQPSQSQKNSSQMNLDEEYFNRIMNNLSEDEISDEAITNESTSSINVQQSRGWILAQSQTCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6E7</accession>
    <name>A0A232F6E7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_004512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000806">
        <property type="protein sequence ID" value="OXU26414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232F6E7"/>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Collagen IV NC1" evidence="10">
        <location>
            <begin position="1487"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1160"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1216"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1354"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1422"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1739"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1377"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1437"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1457"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1473"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1796"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1817"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1829"/>
            <end position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU26414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1841" mass="187215" checksum="9C066608E60BD64F" modified="2017-10-25" version="1">MEVEADAASCSDYKCNCKGIKGDVGIFGITGVQGPEGEPGDTGPDGPEGPKGEKGQSGEIGLTGEKGLRGRAGPTGPRGPDGLDGCNGTDGRAGVPGYPGPHGERGPFGHPGVKGPPGDAGEGGVNTKGVKGERGTAGLDGRPGPEGLRGLPGDNGYPGETGDIGYQGARGLPGLRGDKGDDVTGLKGELGEQGDRGEKGQPNLNASHRPPNTTTRAGPQGPRGYKGEPGEHGRKGEQGNKGLPGHAGRDGLKGTKGEQGDDGPRGKQGVTGPQGPSGEKGQKGAPGYFGKQGPEGAKGEHGDQGRQGTPGRQGAAGEKGRYIPELDEIIRGSIGIQGDVGFPGEPGPPGTPGEPGKIGYIGPPGPPGPQGPAGKPGPKGSSVKGERGDDGPAGPIGYQGPIGLPGPVGPPGEKGFPGITITGPPGRDGFPGIDGQEGPLGDRGEPGAPGPKGFPGKGSPIVGPKGEAGLPGLPGMPGVPGLKGWDGPKGFKGFRGDDCGVCAPGAPGEKGELGTPGYDGFNGAPGFPGLPGPRGYKGAMGMPGAQGAPGLDGENGLHGMGGAQGPKGPAGRVILPGSHHVSPPGDKGDKGFPGIVGLRGIRGRPGEDGDFGFDGPKGEKGDYGMPGNPGRDGQPGWSGIDGLKGEPAPIPKEYLKGDRGYDGAPGPKGERGTPGAKGEVGDSSQHDIMPFKGVVGPRGLEGDDGKDGRKGERGDTGFRGLMGLSGEPGPPGFSAQGPDGVQGFPGEPGDEGPRGPAGFPGGPGIDGMPGLAGPKGDRGDIANNFYYGDLGEMGFKGEEGDMGDFGPPGFRGPPGEPGIKGFKGERGSIGYAGFPGTPGAKGPRGDSIQGWRGEPGLPGIPGRPGMIGDMGFKGLDGAPGFDGDKGVRGNVGLPGRRGPDGETGHQGFTGMDGQLGFPGAPGEDGDIGEVGDVGPKGWEGLMGEPGMNGPKGERGDYGLPGVEGPPGPPGWRGLKGDRGFMGLKGERGENSFSGPQGELGESGFVGAMGPPGPPGVDGKPGLPGTKGLSIDGFMGLKGIRGDNGYHGFNGTKGVKGEPGDFGRDGFKGEMGDVGPKGHKGYPGTHGLSGFKGERGPMGPPGVDGPKGKRGPDGDPGIMGRPGMPGDIGPTGLRGRPGPAGPKGLMGEPGFPGFGNATYGDEGDDGLDGLPGRKGERGPIGYMGAPGRKGEQGEYGMPGMEGFPGFPGQKGMVGDVGPEGPAGPPGEFPEHGEPGVPGLDGRPGLHGRPGFKGSPGDYGYDGPNGMTGEPGISYPGPKGERGDIGPQGYIGFPGAPGMEGMPGFPGPRGPKGMQGDIGYSGISNKGEFGELGLPGLDGRPGAKGQQGDEGFAGITGLPGLKGERGDDGYAGRPGLRGMDGRKGQKGERGHFIPGPRALKGFMGEPGYPGFPGERGLPGIVGEPGEDGIPGRVGETGMTGPPGNPGIDGPDGPDGPEGEAGATGRAGAQGFPGAPGLPAPPGPGPKNRGFYFARHSQSAMIPVCPRNTVKMWDGFSLLHVMGNSYAHAQDLGTPGSCLKKFSVMPFNVCNLNNVCDYANRNDYSYWLSSNEQMPMSMTPIPSREVGAYISRCSVCEAPTRLIVMHSQSMAIPECPGGWEELWAGYSFLMVRIQLSCFFRKIKLQGQSLHRKNVFQHRDAGAAGGGQPLSSPGSCLEEFRARPFIECRGQGTCNFFSTAVSYWMATIKDYEQFRKPQQQTLKTDHTSRVSRCSVCIRRRVSEESAHRGGARPPYQSNVHGGLREPTASYHPDDANNEIEGNGYYQHQRNPGQDWRRYPYGDQTQYQQPQQQQYPQRRRRPNENRRVADNLRRRGRHRKHVEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F6F6</accession>
    <name>A0A232F6F6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_016085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000895">
        <property type="protein sequence ID" value="OXU26028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F6F6"/>
    <dbReference type="OrthoDB" id="6073372at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034629">
        <property type="entry name" value="PTCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700:SF0">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="46625" checksum="44BE8394E3CE830A" modified="2017-10-25" version="1">MAMCVSSLVRNSFNLLGKSVVKQLVINVTRQLYSPNAMGLNGYLNARDYVKSQFLNVDHLFFNKMRDLMENKEDSMVFTEDLKTMLHIVEKKPEDLDLLYTMLKKYHTQNNLRFGSFVFGTVAMRAFYHLDEPDLALKAFKDPELNGFFDQIMSQQLLLDLLYNHGKYSDVRDVYDIIKTKNINGIVHPKNPFIIVMGACYQENTKDSFDYAVNLFKEVQTRGFEFPRRAITFLASLALKQGSPSIALEVASLARNVRYIDIRCIKVEAYAALKRVDEVMVYFRTTLQTDLPTRRKQSYFKDTIEKVEELVESEKLEENSELVKMLKQIKLHDYVQTGTLDEHITTTIDQIRVNNEQRQWQRPEFGNRQSQQQNRYQSNNNFNESNRFNYRKGLRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F880</accession>
    <name>A0A232F880_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_010606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000707">
        <property type="protein sequence ID" value="OXU26865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F880"/>
    <dbReference type="STRING" id="543379.A0A232F880"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="397"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU26865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1146" mass="128561" checksum="D6BB53DE3C41181D" modified="2017-10-25" version="1">MAAELDQFQQLLNTLLSTDNEVRTQAETILDNETYKNLPVESKVQLLLRFICDITVGEELRGMAAILLRRLFSSEFMDFYPKIPPEGQAQLKEQVLVAVQNEPSARIRRRICEVAAEVARNLIDEDGNNQWPEFLQFLFQCANGPVPALKESALRMFTCVPGVFGNQQPNYLDLIKQMLLLSVNDTSNYDVSYYPLNKALVTVWRLIRKCEVALSHFATKSPKNKELSDDCNLSSVQFQAVRAVCAFIMLHDKETAIQKHFAELLPSVVLVTAQSIEKQEEDSLLKGMIDLAESTPKFLRPQLEPIMEMCTKVFSNEDMEDSWRQLALEVIVTLAETAPAMVRKVGGKYITALVPLILKMMTDLEENEEWSFSDEIIEEDNDSNNVVAESALDRLACGLGGKTMLPLIVQNIPTMLSSTDWKYRHAALMAISAVGEGCHKQMEAILPQIMDGIMQYLQDPHPRVRYAACNAVGQMSTDFAPTFEKKFHDVVIPGLLLVLDDNANPRVQAHAGAALVNFSEDCAKSILMPYLDAIMGKLESILTKKFQELVEKGTKLVLEQVVTTIASVADTCEEQFVKYYDRLMPCLKYIITNATQQEHKLLRGKTIECVSLIGLAVGTEKFFGDAQAVMELLLKSHTALPEDDPQLSYMISAWARLCKVLGKHFEPYLPLVMGTVMQTAAMKPEVALLDNEDMEDVESDVDWQFVSLGEQQNFGIKTAGLEDKASACEMLVCYARELKEGFADYAEEVVRLMVPMLKFYFHDGVRTAAAESLPCLLECAKIKGPQYLEGMWNYICPDLLKAIDTEPEADVLLELLYSLAKCIETLGAGCLNPQSMTELLRILDKLLNEHFEKAVARSEKRKDEDYDDVVEEQLADEDNEDLYTLSKIADIFHALFITYKSSFFPYFDQIVGHFVKLLAPDRPWSDHQWALCVFDDVIEYGGPDCAKYQEFFLRPMIQYVADKSGEVRQAAAYGCGVLGQYGGEAFAQACAEALPRLMEVINDPESKASENLNATENAISAVTKILKYNNKAINVDEILPHWLSWLPVVEDEDEAPHVYGYLCDLIEANHPIILGPNNANLPRLISFFAEAFNKDVISSDDPVLPRILSIVRQIQSNESMFQACIAVLSSEQQLALHEALSSQSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8Q6</accession>
    <name>A0A232F8Q6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IkappaB kinase</fullName>
            <ecNumber evidence="2">2.7.11.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TSAR_007050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Alberta</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19073"/>
            <dbReference type="Rhea" id="RHEA-COMP:13698"/>
            <dbReference type="Rhea" id="RHEA-COMP:13699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.10" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000645">
        <property type="protein sequence ID" value="OXU27224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8Q6"/>
    <dbReference type="STRING" id="543379.A0A232F8Q6"/>
    <dbReference type="OrthoDB" id="267381at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008385">
        <property type="term" value="C:IkappaB kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008384">
        <property type="term" value="F:IkappaB kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF17">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OXU27224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="690" mass="80699" checksum="91A116A28ABFCFA4" modified="2017-10-25" version="1">MAQKSYGNWIYEKMLGAGGFGQVELWKEKYTNKRIAIKKCMLPKGSITDRQMERWKQEIENMKHFNHPNIVKSEQVPPEMVLNSPVLCMEFCNKGDLRKVLSNPENSCGLLQNDALTVMKDISSAVMYLHYNNITHRDLKPDNIVLHEKNGMVVYKLIDLGYAKELGSTTMTASLVGTFNYVAPELFWKQKYTCSVDYWSLGITFFEVISGHKPFQPHIQDLPKWIVYMRQNKTYEQICALEIGEKIKFYDNIIYPNDLSESILNKMVEWFRVVLQWNPRKRGKRPDSDEVVVFPMLREIFPWKTISIFFVSLYRMVQYTVYSNSTFGELQLWIEQQTRIPINRQVIADTAGLVFNRNQNYENINLSSIPQTMLYVYDHCNLVLTEEVLSDGPKIPEILDTMVCEPTAIKDHPLLKQCYTALIYIMRYEVTLFKQYTFALCTKLDMIIERSNVLNNNIKTSLPEAEGLLAEVSTSIRSIIPEITPSEIMGSMNNLFDKIQTLYNTINEIKNETDHYSRQMKEAFDTEQFLQNIDKYSKMYEEFLKMYQTFSNEEKKSPDYIADQVRVLSEVFYKIDEQKMQQLQDPTALKIIRQLVCFDEKIHYHHEVINSCIKLITSYRNTFSGLLDNVNQSVNLAPEIPILPNMNVQPMVGNNVPIYDDIEIRDNIALRAAMDQYLQDIQQNWQRMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F8V7</accession>
    <name>A0A232F8V7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_006127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000638">
        <property type="protein sequence ID" value="OXU27256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F8V7"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="66" mass="7531" checksum="150CBFCA8627EB5B" modified="2017-10-25" version="1">MAKIFAFSLHGDYWESTDAKDQPVDRKTVFSFKVSPASAENQKLILVPLLIRSMLSPGFFHTCKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F935</accession>
    <name>A0A232F935_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_008790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000686">
        <property type="protein sequence ID" value="OXU26969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F935"/>
    <dbReference type="OrthoDB" id="7700744at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU26969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="199" mass="22588" checksum="097CE8E9043D7ACD" modified="2017-10-25" version="1">MATQCGPFVSSSVYYGYVQPTAAPNNPQMLQQQQQQQQTNNYQNQQQHNGMEVDCDASQKNQFHQAMFAAAEAQEQRSRKRGFDALPQDFDYEAYVVPRFKKFREGDWLRASSDQHGLAQVYHEPLLRLSPAADCDMACQPATGNLKFQSAVQTRTSCGNGRSQELEDMLLMTHGCSSYHHYRDTRLCSQPGDSEEAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9C3</accession>
    <name>A0A232F9C3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_008600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000676">
        <property type="protein sequence ID" value="OXU27059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9C3"/>
    <dbReference type="STRING" id="543379.A0A232F9C3"/>
    <dbReference type="OrthoDB" id="5916873at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000025">
        <property type="entry name" value="Mesoderm induction early response 1, transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045787">
        <property type="entry name" value="MIER1/3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19426">
        <property type="entry name" value="MIER1_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="7">
        <location>
            <begin position="247"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="351"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="663" mass="72685" checksum="D361E7EFAC358424" modified="2017-10-25" version="1">MSRDESRRSKRCRADRDYEMGPATGIMVNDYDDERTLDEEEALEGSEDTHNELSHLQKESDMPLKDLLVMYNYRDISCQDNKEDEDEDEEDEEDEEEDDEDEDDDDPASYESDLKQFYTEIVKAEENGANVRKSSVAKSGDPARRGEAAALIPAIDAHTTSSSADPKVEDSSGVPENTSGDAQNAGSSEVSSTTDNVNSTSATAGNVGSVGGGSGSSRLLRSVSRPQSEEEEDDCDYSPDDEEEWKKTIMVGQDYQAAIPEGLCRYDDALPYENEDKMLWDPCHINEEAVEEFLEKAQLPVVKGSSLPSGSHVRDDEQALYLLLQCGYNLDEALRRRRMNVLPPTESVSLWSEEECHNFETGLRNYGKDFHLIQKNKVRTRSVGELVQFYYLWKKTERHDIFTYKARLEKKKYALHPGITDYMDRFLEEQEGVRDRSSSPNVHCLMLYGDAKRQRTNANSTSNEEPSCGGGNKSGLDSWDGATTTNASSTTTTTSASGTTTGCTNAETSPPVNASGHADPLALEHLHNSSLATPGTGQLDYAKASSSSNGAGAESSSGPIPWPTTINANVATTIPSSSSSSSSSVSSSTMAQQQPQRNHMHHHMQQQLQHQLQPLSSTNNSHNQQQPLSINPSLIGSSNSSNDEAAAAVAARSPENILPHLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9M0</accession>
    <name>A0A232F9M0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein KRI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000660">
        <property type="protein sequence ID" value="OXU27139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9M0"/>
    <dbReference type="STRING" id="543379.A0A232F9M0"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="4">
        <location>
            <begin position="494"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU27139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="841" mass="99153" checksum="CFB1353D6F239F22" modified="2017-10-25" version="1">MQKLFKNDDSDSEEKLNINTDYATNYDNWRQKEELHKLKARYGEDAETLLKSDEDSSESSEDDEGEEIPEEFEKNFYKTLACLKNKDPRIYDDKVKFFDETDLKSVEGAKKEKKEKSLFLRDYERKIIVERGGKYSDSEDEVNENEAKPRNPTYVQEQQELKESFKKVLEDQDAQEDDLLLKPKTKSKEEKQKEEEAYKEWLKGQKKDINKEQEKELKPLRDFWTDPNLDANEKFLRDYVLNNKFLDKESVDDANLDYEHVAHDSDENLSEDERNINTQEEFEHKYNFRFEEPDQEFIKRYPRTLENSLRKKDTRRAQKRAEVKARKEEEKLKKREELKELKALKRKEIEEKIEKLKEITGNDDLKLDMMDLEGDFDPDEYDKKMSQIFNEDYYAGQEEDAKPEFPDIDEELQVESTWDDYEPGAEEISQEEIPYHDAPHCEDPEFNMDADYNGQSLQEELVESTKKRKKRRRSKFAELISKEKPKFDPTLHPSYQEYYDQYYALDYEDMIGDLPCRFKYRQVVPNDYGLTVEEILMADDRELNKWCSLKKALEHKPEYKELNEVKIYKQKAANEALKKKILKSLYSAPEEETPDPLPGPSGMLPNPGTEGTNKSRKRKRKNKQNGEINAEIANDQQKGKEEKSVENGKSNAKKSKKSKRETESTSEKKDSTTETNLTEENNEPSSKKKIKLDESTEDKQTEVSKKKKKKKKTVQNDLESGKSDFEHMKATVSNEQSKSKPKAQDTVKQSDKTQNVKSSDGEKMKKKQKNKNDKKPEKGVLSKKQQRRLLFLEKNKKKNKKDNKGDSKEVDQIASLSAERLKAYGLNPKKFKNKLKYMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9T2</accession>
    <name>A0A232F9T2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000572">
        <property type="protein sequence ID" value="OXU27606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9T2"/>
    <dbReference type="STRING" id="543379.A0A232F9T2"/>
    <dbReference type="OrthoDB" id="7692121at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="319" mass="36297" checksum="8F9181A22EE08B48" modified="2017-10-25" version="1">MKCQVLPAAELSYCVKCVAVESERVFGDVVVTRRSSAAQLPAAYQRSRQNLVQQYLEGPNFLELNRRRPMRRQSAAVAEEGKRDSELKLVARSTRSKSLNLQGTWLGPDLTEHDRTLKLQILRCVIETSIERSKNANQLLELQSYPCIQRNNSAKARTPTQPLHSTQTYPAAPLPSQYSATKEIVVSSLVDQLLVDIYGPTTVSLCGSEWRTRSGSESTNSSWKSRHHQQPYLQRTRLELKSNGELRIVLGTLRDHVSHTGSLLVRQLRRREYLLSRREKLYNVITAHLQAHSSKRKSQQYTIHLCFGSHNRSNAHTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9Y5</accession>
    <name>A0A232F9Y5_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small monomeric GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TSAR_002213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Alberta</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000641">
        <property type="protein sequence ID" value="OXU27243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9Y5"/>
    <dbReference type="STRING" id="543379.A0A232F9Y5"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001686">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OXU27243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25344" checksum="5DF390638715A017" modified="2017-10-25" version="1">MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEVLNLQPLFSNAKCISRKSRVLCVNHYVQDIGTYREQIKRVKDAEEVPMVLVGNKCDLQQSWAVNMTQAREVARQYGVPFVETSAKTRMGVDDAFYTLVREIRKDKEQRGKEKRKRMKAGNSSRRKHRCCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232F9Y8</accession>
    <name>A0A232F9Y8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_012993</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000660">
        <property type="protein sequence ID" value="OXU27127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232F9Y8"/>
    <dbReference type="STRING" id="543379.A0A232F9Y8"/>
    <dbReference type="OrthoDB" id="10067827at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000027">
        <property type="entry name" value="Nescient helix-loop-helix 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF10">
        <property type="entry name" value="HELIX-LOOP-HELIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU27127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="126" mass="14503" checksum="95581C9654CA917F" modified="2017-10-25" version="1">MCFSCSEREMEREVLLPISACCNLSLQSRRRDRENMANGGHNIVSGVTSGTGSLSREERRRRRRATQKYRTAHATRERVRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYIAYLNHVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FA08</accession>
    <name>A0A232FA08_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000658">
        <property type="protein sequence ID" value="OXU27147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FA08"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU27147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="90" mass="10673" checksum="AC1A088F0AFC1494" modified="2017-10-25" version="1">MIIKHRCDIKLLAYTYTLQGDGIVVATAERLFSHAIGSLYRRRRRRRMTSNIISEYTRDRLLPLCHIVVTYIYRVLCGRLVDIPRDVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAJ7</accession>
    <name>A0A232FAJ7_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TSAR_003767</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Alberta</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="NNAY01000525">
        <property type="protein sequence ID" value="OXU27866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAJ7"/>
    <dbReference type="STRING" id="543379.A0A232FAJ7"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000009">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000002">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="14"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="325"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OXU27866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="551" mass="62209" checksum="3765FDD16C9ACA77" modified="2017-10-25" version="1">MAAQPACTRFSDNYDLKEELGKGAFSVVRRCVQKSTNLEFAAKIINTKKLSSRDFQKLEREARICRKLQHPNIVRLHDSIQEENFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVHHCHHNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDTQAWYGFAGTPGYLSPEVLKKEPYGKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKSGSYDYPTPEWDTVTPEAKNLINQMLTVNPSKRITASEALKHPWICQRERVASIVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSKYEAPGRSIITKKGDGSQVKESTDSTTTLEDDDVKEDKKGGVDRSSTVIAKEPEEAEGPRQTPGGYVQLGYDLEDDIRIVCPIKTCSQLSTNSQCSARRQEIIKMTEQLIESINTGDFEAYTKICDPHLTAFEPEALGNLVEGMEFHKFYFDNVVLGKNCKAVNTTILNPHVHLLGEDAACIAYVRLTQYMDKQGVAHTQQSEESRVWHKKDNKWQNVHFHRSAVTGPSPFSFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FAP6</accession>
    <name>A0A232FAP6_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_013718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000556">
        <property type="protein sequence ID" value="OXU27692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FAP6"/>
    <dbReference type="STRING" id="543379.A0A232FAP6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000138">
        <property type="entry name" value="Homeobox protein prophet of Pit-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF520">
        <property type="entry name" value="ALX HOMEOBOX PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU27692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="292" mass="32922" checksum="42F047C2C00E8A0A" modified="2017-10-25" version="1" fragment="single">ECVIADANLSFCCDRETRLVRRVGSVADGKKRGDWSEDRASGSMRISCGAWPATESRAVEEERRVRDSRGVFKKLKACPKTRIVGAEGAFKKLKPEPCASSSHIGHTPTTASCPTPARRRHRTTFTQEQLAELESAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPIPTCQGAMMRNIYPGASRGYQPYPHPHNSINGINRYPQMSSASYPSMTQPFSMTHSATNMSAVTGMRQESMGMSAEDEWYNKSISALRMNTAHHPNLTAPMLQYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FB74</accession>
    <name>A0A232FB74_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NHR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_003159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000548">
        <property type="protein sequence ID" value="OXU27740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FB74"/>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000001">
        <property type="entry name" value="neuralized-like protein 4 isoform X1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000014">
        <property type="entry name" value="neuralized-like protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF14">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="226"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="424"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="616"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="817"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU27740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1763" mass="193815" checksum="382558C282894949" modified="2017-10-25" version="1">MLLFHRRCGDRVSLVNGQCTAVRDVTEFNFGLVFSAEPLRNDEVFQVRIDKKIMIWSGSIEIGVTTCDPDNTNLPASATSLRHGSWIMTGSSIVYDGEPISEVYGADLSTLDEGNTLGVCRTSKGELVFYVNGSPQGIAATNIPSRVYAVINMYGNCVQVTTVQPPSGSASNCSNGEATSHQIEINNDYTMDEASSSLITNLVANLNVNLNVLPKNPSLAAIREDRLRFHERVGSLVKLSNNARTAERRRPLDEFNNGVVMTHRSLRDNELFEIRIDRLVDKWSGSIEVGVTTHSPTALEFPATMTNMRSGTTMMSGCGILTNGKGTQREYGEFNLDELREGDRVGMMRKSNGNLHYFINGLDQGVASKVPNTIWGVIDLYGMTVKVTIVDRDEREEQNLITRRNTLQLQGINEGGETEEPLDRLMFHPCCGTRADVINNGRTAHRPNAIDDFNNGVVLTSRPLRPNELFEVRLDKIVTKWAGSIEIGVTTHSPTELEFPFTMTNVRSGTWMMTGNGVMHNGTTMIDQYGQNLDRLQVGDRVGVMRKDNSTLHFYVNGSDQGAAASGVPERVYGVIDLYGQAAQATIVDNSDFCSPTTINSSLSNTTLYWYENENDLRFHHVHGKNARITNNGLTASRPRALGEFNDAIVVANRALRDGEMFEVSIDKMVDRWSGAIEAGVTAIRPDELEFPSTMTDIDHDTWMLSGSTVMRDGVALRHNYSCDLDKLAEGNRIGMMRCADASLHYYLDGVDQGTACTGLPAHVYPVIDLYGQCAQVTIVIPERRDMTLQQYLPSENSTTSQQPTSVVQALAQTEITHKFHESVGLNIQLDTGRTVATRCREYSNAVLLSETALENNEIFEISIQEVAREWSGSLRIGLISNESGSWLSSMNLVQGMTSIPADAWYLTGNQVRHKGQCLCWNYCPSLDWLRVGDKIGLKRTNEGNLKFYVNREDMGVAASNVPEMCYAVVELFGSTVAVCITSTKQQNTAISPNASLRLQDSLELLLDPMPPGIRNEAGMDTSVDTCGEGKQINEIVTTPTQLTVASIGETDWSYEFHENHGRNVQLEKKTVARRVASYNQGVVMSNKPLIKNKLFQVKIDKINERWVSGMLCGVSCVSPEKVTFPVTALGLKKHSWIICGDWISHNGTKVRSSYGANLESLRVGSTVGLLLDEDSRLHLYIDGSDQGIAASDLPSYVYAVIDLYGQCEQVSIIGPSAEAMILPLLNENEMLNNDTNNATVSAMERLALETDDVENSREKADLECHEKESGAAMLVDEMKDGSAEMSVQDEGGCSRTDDQVDEMESLTNVTAKDNDLASRNSQSSNKELKQVPASSTMSSSLQSDTNCSEHCSDAVSTSETTSNIPDNNTYADKDVIPPPLHNNNVTAVVPTGSIEDNCEGNSSDIEPTADNNDSCTNVELNNATNINIKNGSVINSTNMTNLNTAISGSNANNAINESIASNSSQNNNNATTTPSLNIRTWHSNHCAPSAPQELVLNLHRHSLSFFNQQGFQISNNCFSNNILTTAAQQTISTHASMPSTPLATSNHITPPPSKKCEYLKACVRLKKSLVLPDEFFSLDEILCYCSSCFKIDGDSVICKKGEPLAEFAIPVGWVRFPLKHNINANQIPQSTTDKWHVAFYGTRIDTVRWILDRGELLTKEQLDTDSLTTGTSTEDQNPQVVFSPNIKCASSEEFTKQYSYIDTQLNKKVNASTAFQLLVRPGSYTTSSKKDGLDSQLECIEWATKETGATVIIALLIHLDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCM4</accession>
    <name>A0A232FCM4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TSAR_008341</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Alberta</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000462">
        <property type="protein sequence ID" value="OXU28208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCM4"/>
    <dbReference type="STRING" id="543379.A0A232FCM4"/>
    <dbReference type="OrthoDB" id="8186464at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012511540" description="Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein" evidence="14">
        <location>
            <begin position="24"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1015"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1186"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="228"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="839"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OXU28208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1218" mass="139545" checksum="12E74D5E0168C382" modified="2017-10-25" version="1">MLLSTAVFLPILAVFLKLETIGSLEVADDAMYDEYKEYVLLVSDVQEHYKASSVIIVYAGDDESIHTTTLMMRLTREFSSKFVLSLSLNYTDLTQHYDHYRTRIVRPLFVVFLNSASEVRMFQKASQRFEISYPFWLVIFAKPTLRTCYEPTENYFNVAFDTEMMVKCYGDPILREWYSLKEDSITVHDLAHWDLLGRLQPKTTKSLYERRHTLAGKNLRIATVKDSPFIAAQQGPLSGLFATILEELSSTLNFSMSIAYKEDSYGIYNESTGVWTGVIGRLDRKDVDLGVAEFTMTAQRLDSVDFTQPIMLSRNHLYMRQPDGSALQWSAYFKVYTIDSWIALQGMSTLTWLVITYMRALIREKPIPPNHFSENYLSIWGIYCQQGLPEFPSASPMRIAYFTILVTAVILLAVYSACLISYLTVTSPSLPFSNLHEFAKDGTYKLIAFQQSADYDLFATSKDLVLKRMMKQMLNREYLPQTMMAGFRKACENKIAFYATEAVKTQISARIPCDLVYLESGRIDSLGMTLTKRSQYTGVINYHLQKFKDVGIMNRLRSRVYMKVTPSDNKYNPVNVRGIVTILLILGIGVVVSIIILIAEILIQRVHKGKENQKLMSTCKNQIVVTKNALITTFVLLFSIGNRALQIDPEDYVPFLSDVQEYYKSSGILFLYDDDSDYFQTLSNLGIFFKLLSDRGILSQAIRFSKIREKYDLSRNVQNLFVVFVTSRSNFDNFCLATWDHDMSYHTWLVIFADSVEAEVNEMCLNPSGNPFHLVFNSRMIVRCHNEDWIRKWYSLQENQTEVLDLAKWNRKLGISYKNKNYYESRYDLMGKTIRIATHTFMTSSTNGKMSGFLEDILQELENFMNFTVARVREEDAFGKWDKEAHRWTGLIGSLTNREVDLVVAPITINKFRLRFIDFTMPLLLSKNRIYIKQPDGARVQWSAYFKAFSISSWSFIALVLIAASLMTALIRLIVHETKVLQLSLNYLLENFIRVWGIYCQQGIPEFPSSTSLRLAYFTMLLLTLIIWAIYSASITSYLTFLSPSLPFSDTEGFVRDGSYKLIVLQNSSDQDIILSGLDPILATFQPLLKDLDELPKNPHSGFLQVCDERVGFYASEAVLKGVSGYIPCTLTYIETGQFECLALALRKRSPYITLRKLEDNGVVKKLNNWYFRKVDNAVESTHSPIGIWGVAPLLTIFATGLAMSSLVLLLECLNTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FCX9</accession>
    <name>A0A232FCX9_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubulin-specific chaperone D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_000146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000450">
        <property type="protein sequence ID" value="OXU28308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FCX9"/>
    <dbReference type="STRING" id="543379.A0A232FCX9"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034333">
        <property type="term" value="P:adherens junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="5">
        <location>
            <begin position="273"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="4">
        <location>
            <begin position="867"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OXU28308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1155" mass="131862" checksum="CC60992FBD9859AB" modified="2017-10-25" version="1">MIVNDNESESNNCGGGHSAFKEIDEINHLIQQLHLPDLPTRIMEKNQDRFCFILKQYQDQPQLLDPYLESFLSPLIKFIREKTEFDYLKHYVFKYIYIIMSVKTYKKIAIHLPHEVTDFNPVLEMLENQDINDKDNWQTRYVLLVWLSIITKIPFAMSRLETGVSTGANSEQTITQRVIDICKKYCSSKDACSPAAIFLVANFLTRFDVKERYLDDMIKWSLNHFETDHWNHRPLAVISSIIKHSCREDISPYTQLILDKITENKLNESSADLVRKFSMKIIQRIGMILLKANVTPWRYKKASKVIILNANPTDSSSIEPVAIDKEFTEAENEDHEIPPIMEDILEHLITGLQDKSIIIRWSAAKGIGRITARLPIDLADDVLGFVLNLFSSRESETAWHGGCLALAELGRRGLLLPYRLKDFIPLVIQALVFDEPRAYGPVGSIIRDAACFVCWSFARAFEPHVFEPYVKEIAPALLIVTCFDREINCRRAGSAAFQENVGRQGNFPHGIDIIAAADYFEVGVRSNAFLKISVHVAKYEGYLKPLVDHLVKRKVTHWDVAIRELAAKALHNLTELDTSYMIEEVLPTLIGFIDSIDLFVRHGAILSIAEILVALHKTLGKSIEEIVDSNDLDEIKNIVSTCRSRGQLRGLGGEVIKQACVTLIKKFALVHFHVDNQTIINDWQNLLEECLSNEVSSVRIVSAEAHTAFFTEYYFTWNQENRHAIINRYLDNLQSTSQTNRIGFAQAIGHFPEPVLKEKNEDIFKKLMKCCYIAKETTLWAESRKEAMISLRKICETLGLEHTEQWKLFVDDLYECLFNGLGEYTNDSRGDIGSWVREAAISGILSLTNLIYDAKFTSMLNENLMKNVIGGISQQAVERIDRTRAKAGTAFNSLIRSDLPNIPYHKELRTLFCINDDSGKYIDWKSESETFPLFIQMLSFPPYVQYLLKGIIFSVGGLSESLVKHSSMSLFTYLQQLDKTTLSSLCQEICNIFEACHGDDRMISASLAFLDRLFSSGCIQNILDDPDNEIPRRILTLLKKESKSINATQSQLNSVKLFCHLLQVRGPVSKGAFSQLSIYLCHKFKFVRKATASRLYESLTLYGDDMDMTEEELAVLLTQLNTIDWEKPVEELRPIRNQLCEIMKCPAPMLRQKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FDE0</accession>
    <name>A0A232FDE0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stathmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TSAR_006418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Alberta</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000441">
        <property type="protein sequence ID" value="OXU28367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FDE0"/>
    <dbReference type="STRING" id="543379.A0A232FDE0"/>
    <dbReference type="OrthoDB" id="5986631at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF1">
        <property type="entry name" value="STATHMIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OXU28367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42790" checksum="79EE262C3234C381" modified="2017-10-25" version="1">MTDLDVKEETKIIAAEGNHGFECDVCFSSIRWTFYLSCRNKLGTKNSKHLGKHPLKTHYSCNYSNFSIPSATEIRCQEKTKGGLRYEVILAEPTAPAKRAPSPTHQTSPTQPAVNIEDKLRAAEERRLSLEASKIAALNARLSKIEEVARKKDELNASFVNATRESLDIKMNNSEEKREAFITDLRSKLKEHLEGVEKTRLTIEQQTEEVRVAIDEKLKNASGKRGENIKSIVERLKEHEERVATVRQGIADRVLQLESQIQSKLDQARERRELIEREQKEKLRNHNTVRLAKVREVAGANVARDVEAIKRESDARLISAEINRQREIQRRVQAIRQHEKRVEMVRQNKAKVQTKEGQDGIMDNMPVVNETASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FER8</accession>
    <name>A0A232FER8_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_011282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000328">
        <property type="protein sequence ID" value="OXU29185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FER8"/>
    <dbReference type="STRING" id="543379.A0A232FER8"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU29185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="567" mass="63817" checksum="36304A5F7A556447" modified="2017-10-25" version="1">MEAKTYGWKFLSASDGPSNDGPSNDGSKSIVYERQGHFSSLDVIRTKGDLCDVIIDVEDKSFPAHRIILASTIKYFQELILNSSDEETKATISVKDVSAQSMESILTFAYTGAITITEENAQTLLVDADHLGLTDITEQCIKFFYTCLRPSNVSQIYSLAEARGIEPLMKKCKKFMVAHFEDVCKTDEYLNFDILLLKDIFSNHEIHADLEQLFDAAIRWITYNIHQRRFYTTELLSYARLSNLQSQVVIEYFSKIPSLVEENSEFVSEIVSLYETFEKIVYINEKKLIYVVAAEDSNNIEIYDPVIDQWDVANFVDRGENKQEFSCVVHKRKLYIIGGQSQKLGFKKTVQINDLETKTWTSVAPMHSERSLSGAVVLNDFIYVCGGRNYSGPCNVVERYSPESNEWRMMCPMNICRSTLAVVALGDAIYAIGGTFDNAPLDTVERYDPDKNWWKSLNSIMHEKREQCGAAALNGKIYVCGGYNDDGAISSVEVYNPQTNRWTKLADMNSPRSGALVIANMGKIWAIGGCGTDYNELSSVEIYDPETDTWTVTGPMSKIKGYVTGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FF50</accession>
    <name>A0A232FF50_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TSAR_014315</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Alberta</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000340">
        <property type="protein sequence ID" value="OXU29078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FF50"/>
    <dbReference type="STRING" id="543379.A0A232FF50"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003800">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000002">
        <property type="entry name" value="guanine nucleotide-binding protein G(Q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF362">
        <property type="entry name" value="G PROTEIN ALPHA O SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OXU29078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="224" mass="26440" checksum="C358B8DCE97C4DCE" modified="2017-10-25" version="1">MPSLGINFSTNEREKMSVWMCVYVYRNISKTTPSISIKLKMHLYFWILNSGETTDAKMVFDVIQRMEDTEPFSEELLLAMKRLWADVGVQDCFGRSNEYQLNDSAKYFLDDLDRLGAKEYQPTEQDILRTRVKTTGIVEVHFSFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTILDSIQNMFERHYRLSIVLKSEKELLHQFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FFS1</accession>
    <name>A0A232FFS1_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000277">
        <property type="protein sequence ID" value="OXU29552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FFS1"/>
    <dbReference type="STRING" id="543379.A0A232FFS1"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="127" mass="14327" checksum="DAEACC63BBC6F2BE" modified="2017-10-25" version="1">MFHIDYISTVDPFGDDPFAALHAPTRSDSPSPALPPKKTKLPPPRPAPPRPMQGPQLSSTSTVPGSAFVASHSDPFAEKAVSFHTDTTDSFEFADFANFDSKKFNDFNTLLFRYYERDYKIKHRYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG25</accession>
    <name>A0A232FG25_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_009375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000250">
        <property type="protein sequence ID" value="OXU29711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FG25"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU29711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="46" mass="5633" checksum="A73B17AB8304D43F" modified="2017-10-25" version="1">MSGRLEDGREQKFDERRLYLNQRRDRAPRSRARTRSLMNSQPSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FG86</accession>
    <name>A0A232FG86_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">KASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TSAR_015301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Alberta</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000242">
        <property type="protein sequence ID" value="OXU29764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FG86"/>
    <dbReference type="OrthoDB" id="6538186at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF10">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="625"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1702"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1881"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2414"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2582"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2880"/>
            <end position="3699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3731"/>
            <end position="3754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3897"/>
            <end position="3948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3976"/>
            <end position="4022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4643"/>
            <end position="4705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="5001"/>
            <end position="5358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="5558"/>
            <end position="5578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="5602"/>
            <end position="5662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="5694"/>
            <end position="5713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="369"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="2535"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="4187"/>
            <end position="4238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="5917"/>
            <end position="6012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1081"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1204"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1305"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1320"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1725"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1763"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1791"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1805"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1881"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1927"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1938"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1959"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2032"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2253"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2278"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2302"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2336"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2414"/>
            <end position="2425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2453"/>
            <end position="2469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2605"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2625"/>
            <end position="2651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2652"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2683"/>
            <end position="2692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2884"/>
            <end position="2896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2897"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2936"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2999"/>
            <end position="3026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3041"/>
            <end position="3056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3057"/>
            <end position="3068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3069"/>
            <end position="3181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3189"/>
            <end position="3244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3251"/>
            <end position="3294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3303"/>
            <end position="3360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3367"/>
            <end position="3452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3459"/>
            <end position="3692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="3731"/>
            <end position="3753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="3906"/>
            <end position="3916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="3929"/>
            <end position="3942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="3991"/>
            <end position="4002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="4679"/>
            <end position="4690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="5040"/>
            <end position="5050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="5063"/>
            <end position="5072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="5078"/>
            <end position="5089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="5139"/>
            <end position="5152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="5182"/>
            <end position="5197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="5223"/>
            <end position="5242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="5310"/>
            <end position="5354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="5604"/>
            <end position="5615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="5624"/>
            <end position="5642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="5643"/>
            <end position="5662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="5701"/>
            <end position="5712"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OXU29764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="6686" mass="760615" checksum="FFB68BD615489CD9" modified="2017-10-25" version="1" fragment="single">[encoded data, 6686 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FHP4</accession>
    <name>A0A232FHP4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_014673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000196">
        <property type="protein sequence ID" value="OXU30083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FHP4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="64" mass="7616" checksum="C80DAA097EF5E56D" modified="2017-10-25" version="1">MPLNNGYFSTNWKGLENSVTRHFFDVGTWFCMVLNMYDKKKKLRECAPTFVFFGFSNQKMAFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FI75</accession>
    <name>A0A232FI75_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TSAR_013147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Alberta</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000182">
        <property type="protein sequence ID" value="OXU30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FI75"/>
    <dbReference type="STRING" id="543379.A0A232FI75"/>
    <dbReference type="OrthoDB" id="8174700at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013008749" description="Protein takeout" evidence="4">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OXU30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29571" checksum="D3D21E2DAFEFF06A" modified="2017-10-25" version="1">MFGRLVTLLAVASLFRVDAEPSDSSAEIPSFLKICRRSDPHLNECIKRSVDSLRPYLRTGIPALHIPPCEPLGVPEIELSQAAGPVSISSAYTNIKVWGGTDFILKSVNHENNSQNRLDLDKDRIRLKLYIPHLEMLSNYNMEGKILMLPITGKGLASGNYTDIDVVVTIQGEKYQNQRTDKTHFRVNEFYCDFDVGHASIHLDNLFNGDETLADAMNLFLNDNWKLVAAEMKPALEDTVSRLFKSFSNKIYAKYPVDTLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FJC5</accession>
    <name>A0A232FJC5_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000115">
        <property type="protein sequence ID" value="OXU30831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FJC5"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU30831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="109" mass="12809" checksum="6033F4790360535E" modified="2017-10-25" version="1">MDFEVFPKFSHTEYLLLLYWSRFHKAISTFIGNTLLSDKKQAGSIELKLVCYEKCRGPTEVKWLQEFCNVHCADKLHTPRVTKQEERLDNLKRICQESCLTEEKGHLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL62</accession>
    <name>A0A232FL62_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Beta-glucuronidase</fullName>
            <ecNumber evidence="5 12">3.2.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TSAR_017008</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Alberta</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Plays an important role in the degradation of dermatan and keratan sulfates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:17633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:83411"/>
            <dbReference type="EC" id="3.2.1.31"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Inhibited by L-aspartic acid.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.31" evidence="5 12"/>
    <dbReference type="EMBL" id="NNAY01000055">
        <property type="protein sequence ID" value="OXU31484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FL62"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000027">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000628">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000029">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007538">
        <property type="entry name" value="PRK10150.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012398588" description="Beta-glucuronidase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="16">
        <location>
            <begin position="60"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="14">
        <location>
            <begin position="239"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="15">
        <location>
            <begin position="348"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="16">
        <location>
            <begin position="754"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="14">
        <location>
            <begin position="883"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="15">
        <location>
            <begin position="994"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="16">
        <location>
            <begin position="1342"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="14">
        <location>
            <begin position="1521"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="15">
        <location>
            <begin position="1629"/>
            <end position="1923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OXU31484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="1946" mass="222894" checksum="A5A5892F80DDEE56" modified="2017-10-25" version="1">MWRQFLLALAGAALVMGTEVNVKDPGMLPEADEFAISPEEPPIPPLPGMLYPRESESREIKSLDGFWDFVVPPSNDVKKGHREGWYSDSLTKAGKVMQMPVPSSYNDITTSKALRDHVGPVWYEKTFFIPASWQYKRVFLRFGSVNYLAEVWLNGELLTNHELGHLPFEVELTEKALYGQQNRITVAVDNSLLANSVPQGNVYDVGADNGTVKVQYYTFDFFNYAGIHRPVLLHTKPRVFVDDLNVTTGLINDVGIIKYSVDIAGAGEKEVPVCEVNLLDANNQYLLTTPVMGTQGTFKVSSPNLWWPRTMSSNPGYMYTLEVTVHVPNSSEPDIYRLPVGIRTLRWTNTTFLINEKPIYFRGFGRHEDSAIRGRGLDLPTVARDYELLQWVGANAYRTSHYPYSDEVLDVADRLGFLIVDECPSVNTENYTPELLKRHKQSLSELIRRDKNRPSVVLWSIANEPRTQLADTGVYFKQVAQHTKTLDPSRPITIALARSVVEDKAGQYLDIISFNRYNSWYQNSGRTDMIIKNVVNEAQNWHNKYKKPVLMSEYGGDTMPGLHELPSYIWSEEYQTEIMSKHFEAFDQLRARGFFIGEFIWNFADFRTAETYTRVGGNKKGIFTRDRQPKSAAFHVRRRYHALSAELDSNPELPNDLENYVSSYYSILNFFALFLEITGLASDDPPLTPLPGLLFPRESETREVKSLDGFWDFLAPPAMDVQRGYSHALYMQELSKAGKVTQMPVPSSYNDITTSSALRDHVGPVWYEKSFYVPVAWKDKRVFLRFGSVNYLARVWLNGYFMTNHEMGHLPFEAEITSEVIFGGKNRVTIAVDNVLLQTSVPQGKIRDVEVDNATVKVQTYTFDFFNYAGIHRPVLLHAKPKAYIDDISVNTEVINDIGVIKYKISIAGLKPNESYACDVNLVDVDNKRVVKGLFAGNEGVLKVVSPNLWWPRSMDENPGYMYTLEVVLSVTNSTERDVYRLPIGIRSLEWTYNSLLINGKPIYFRGFGRHEDSAIRGRGLDLPTVARDHELLAWIEANSYRTSHYPYSEEVLDVADRMGFLVIDECPSVDTENYNELLLERHKISLSELIRRDKNRPSVIMWSVANEPKTGNYEASWYFKQVTQHTRYLDKTRPITMALATSPNEDYAGKYLDIISFNRYNGWYSNPGKIDMITRKVVAEAQTWHNKYKKPVIMAEYGADTMIGLHELPEYIWSEEYQMEVMSRHFEAFDQLRAQGFFIGEFIWNFADFRTAQTYTRVGGNRKGVFTRDRQPKMVAHHVRRRYRSLSIELDNAKVANGKKKSMFGKYFGSYSSGDLTKVEPTTTKLPGLLYPRESESREVKSLDGFWDFVIPPADDVQKGHRELWHTDTLSKFDNVIQMPVPSSYNDITTSSALRDHIGPVWYEKSFFIPSSWKSEKVFLRFGSVNYLAQVWLNGDLLTNHEIGHLPFEAEITTFIVFGAKNRVTVAVDNSLLKTTVPQGKIISMESDNGPVKVQTYSFDFFNYAGIHRPVILHTKPKIYIDDITITTELAGDVGIINYMIEIAGLEETDLPICHVNLIDANNQFATDGPHIGIQGIIEIKSPKLWWPRSMNENPGYLYTFEVAVTTSNSPKIDIYRLPIGIRNIEWTTSSFLINNKPVYFRGFGRHEDSPIRGRGLDLVTVARDHELLKWIGANAYRTSHYPYSDEVLDMADKLGFLIIDECPSVDTESYSSTLLKKHKRSLSELIRRDKNRPSVVMWSIANEPRTQHRNASSYFKQIVQHTKSLDSTRPVTIAIAVSSSEDKVGQYLDVISFNRYNAWYSNPGRLDMITKRIVTEAQAWHNKYKKPVLMSEYGADTMQGLHELPEYIWSEEYQTQLISKHFKAFDLLRAEGFFIGEFIWNFADFRTAQTYTRVGGNKKGVFTRDRQPKMVAHHIRKRYHALGAEQDESKLPNDLENYISSHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FL63</accession>
    <name>A0A232FL63_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_012152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000073">
        <property type="protein sequence ID" value="OXU31250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FL63"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU31250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="101" mass="11314" checksum="22A734C28C56A80E" modified="2017-10-25" version="1">MAFIRSNRSSISNSSSKRSLQTVQEKVCCLIDNAPTLLMMLEHVSWAMEAIQSLPPLSPFAAMQQLYNTYASPRSSRKDEDEDHSSSHPAEIALERTEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FLG2</accession>
    <name>A0A232FLG2_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein diaphanous</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TSAR_002091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Alberta</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. Diaphanous subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000066">
        <property type="protein sequence ID" value="OXU31350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232FLG2"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.40">
        <property type="entry name" value="Formin, diaphanous GTPase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044933">
        <property type="entry name" value="DIA_GBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010465">
        <property type="entry name" value="Drf_DAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06345">
        <property type="entry name" value="Drf_DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="7">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="8">
        <location>
            <begin position="559"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="6">
        <location>
            <begin position="979"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OXU31350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1383" mass="156936" checksum="4067E042FC529DAF" modified="2017-10-25" version="1">MPRPHSGDDFNEVEQQRCMIERMDEETTNDKFEELLANMNLSEEKKEPLRQQSERKKKEMLILHYKGSIQDSRNKFDKPADYIQYLSQPDLSINKIHTCIESLRIALTNNPLSWVQEFGTKGLKQVLVILNECYRNSFIHFNSDSRYERIQYECIRCLKAIMNNTVGIKEILAHHEALTIVARSLEPNKPSVMCEAVKLLGAVCLISSDSHKKVLDAITMNGEFNGRDRFLPIVQGLMNKQNENLRVVCLQLINSIISSAEELDFRLHLRNEIMRAGLADILETLEGEDESEDLVRHLKIFNDYKDEDYEEFVQRFDHVRLELDDVNDCFEVVKNMVMDTVAEPYFLSILQHLLFIRDDALIRPAYYKLIEECVSQIVLHRSGCDPDFSATKRFQIDVQPLIETLVEKSKAEDEHRLSEMSQKLEEAIARKQEAEAKLQHAENVIRELEKGTGRSASSLPKSNNCPPPPPMPGMGGGPPPPPPPPMMGNFGGAPPPPPMPGMGGPRPPPPPPMMGGGPGGGPPPPPMPGGMGPPPPPMMGGPRLPMANAVQVLPHGLKPKKKWEVEGPLKRANWKAILPHKMTEKSFWVKVQEDKLASPEILNGLAQKFSSKPAHKKMDDVVDKSAPSKKVKDLKVLDGKSAQNILILINGTLKHMSYDEVKTCLLRCEGPVIHDNILQGLIQYLPPPDQLTKLLNYKDQYDDLTEAEQFCVKVSQIKRLLPRLRSLSFMLKYDELVQDVKPDIVAGTAACEEVMSSKKFAKILELILLLGNYMNSGSKNGQAFGFEISFLTKLTSTKDIENKQTLLHYLVDTIERKFPDCLNFFEELGHVDKASRVSLENIQRTLRQMDANIRNLEQDLNNAKIPQSDQDNFAKVMTPFAKKARESYEIMQNMFKNMDGLYNEISEFFAFDKQKYTIEEFFGDIKRFKDDFMQAQKEIIKLREADEKQRRAREAREKAEAERAARAERKRALVDMNAHETQEGVMDSLMEALQTGSAFSRPDQRRKRQTRAAGGKSRLGPRTKNYVMLASRLKFANKAWKFKPTLKQANINGPNIESHDTTRTDSNNESFNDFGKEFDSIISGIKGLIDNDNNVSLLGYSTVSDKIKLYSNMGDNKKVIQIFKCKGHRRVPKHSSLSKKAVSASRPKIIVGKRPKRNAFVRQAIIRRRRKVVKRTKSRRLGKYLGSPPNANVTLPTFTKSMISPNTRKIIKPSMSCNDLPTVVNEASVALLLSKFTNEQQNPKEIDENDNTLDVSLERSYDKCKEPPIDDTMTEANNSNFLEKKTLKLKRFFTFRGQKLLSESFRSIKSNDGKKDPSQVINVINAISPQTEIYKRSVNWKIWKGTKNTAERRAQLNRSRSRTGLVGTGLLGRELSTELLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232FMJ4</accession>
    <name>A0A232FMJ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01000014">
        <property type="protein sequence ID" value="OXU31961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232FMJ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU31961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="147" mass="17297" checksum="DD3D639AB651775B" modified="2017-10-25" version="1">MAIKNNDQRLELLGIINSMVKSENSQDFDSYLADFNEKAHTDVKNYFDLNWLPIKTEWWELHRNLEMSYKDIQLVLKVDTNIKYAYNKVLIQLQYYPYITIRNVTNTTIECTVMQVTKTEDIIHVTPASCTCFDRINGKKEEHLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EDS4</accession>
    <name>A0A232EDS4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005936">
        <property type="protein sequence ID" value="OXU16516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EDS4"/>
    <dbReference type="STRING" id="543379.A0A232EDS4"/>
    <dbReference type="OrthoDB" id="7536850at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU16516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22976" checksum="F25170D4C295F8A8" modified="2017-10-25" version="1">MAEYWHRTKKKKLRISIAKLEQVIDQFASYDTRIVLGDFNAKIGREEMFRPTIGKESLHEASNDIGIRGINFAAAKDLIIKTTCLKHKDIHKASLTSPDGATQNQIDHFLIERRRHTNVLDVRAHRGADSDSDHFLVVAKLRAKLVANQNSKQTNKVESFEIEKLRDRTERIRYQIKINNRFQALEEANTSPKGNDEPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EEI3</accession>
    <name>A0A232EEI3_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_014502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01005320">
        <property type="protein sequence ID" value="OXU16757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EEI3"/>
    <dbReference type="OrthoDB" id="8194670at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013280167" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU16757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="136" mass="15364" checksum="0DD15F18B3AE6395" modified="2017-10-25" version="1">MRLFAFAHVLGIVLLIHNSATKTNEERFWDYVDVLKDCAKENGISIESYAYASKKNNTDGIYEKSKCVEACMFKSHKIMRPDGTIDMEKAIEHLLTGNPGEKRDLMKKNIEACEIPNGDNECEVAHTMVKCALGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EFR7</accession>
    <name>A0A232EFR7_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004950">
        <property type="protein sequence ID" value="OXU17196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EFR7"/>
    <dbReference type="STRING" id="543379.A0A232EFR7"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="892" mass="99405" checksum="A9C476219C447304" modified="2017-10-25" version="1" fragment="single">GRSAEPPTGDESKPSIRNSFLQSLERKLEKFRSTDDASKPQQQACKPPGQTILSRLRKNAYKGSRSDSVLSSSDAATSKIPTKKVQAELKKPSPEKSTTLGFKRSPSKDKDKETTPPKRVSPESKKPAMERLSKTLKKSPEKLLKGKTDKTEKPADLKKDASTGKLSEKKKSPEKSFLKAKSPEKSFMKAKSPEKIVIDNKQIEDMNGQVEEMGVAKLKKKLATSPDNGSSLKSDKSDGVKKVKKVVKAKELSDKDKDKDGEENTKKKRIVRVVRKVVKKSSDSSDSKSEDKEKPTKTVVVKKSVVAKKDKSSETPAATTTIRRKSPEDQTPVQSEQAMETAKTADTGEKSVNENAEMMEKDKDFNEIHKAQVCQVDNGVALPKQPEIKPSREKLKLDFSKIPQHNFRNVTPPRRESPKSENAKSEIGDACKLVQRSQSDDVSGKLSEALPKLTHRATFMGNKIVVDKPLMAKDIADLKTEANVEGAKISESENRLDESASISNEIGKENCNVDLNSLNSPQEIEKNNTEETNEMKMSNSSSKDPISTEDLMSPTEDTESFDSWSICSADINHTRGDLHSPTSPTYSMYMRGNNPNAESVIDRIRRKSFYSRFNDRKRKASLNAPPPGVNMSSSMTLPRKFSFNSPRDSNKEQPSKAKTNNYTLPNRKNAEKCYSMYNEEVPTFRKSPIERDRYSDGGSASSYSNDLKSPGETYGHISSPYDPLRKYLSPTFDSSATRRKYHSTEFSTDNDVGSYRNSSLTDSILEPSTSRNISSLPRRYGSSLSGFEPKTVEYYEELLAPNHTDYLGGRRASPLPHENYSKYENGYHNGSIDLPQFSTDKWKSHAEKSTKTDPSDGIQIEDRARKMSLCISEPDDMSSSSLDQRATTSTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EG40</accession>
    <name>A0A232EG40_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uracil phosphoribosyltransferase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TSAR_006170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Alberta</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004866">
        <property type="protein sequence ID" value="OXU17325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EG40"/>
    <dbReference type="STRING" id="543379.A0A232EG40"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000026">
        <property type="entry name" value="Uracil phosphoribosyltransferase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OXU17325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="259" mass="28613" checksum="23E896F32B51C82A" modified="2017-10-25" version="1">MAGLCSQVMILESVVENGGSSDDSSKMGSADAATKKLLPENGCAVQPQNDISEEEYGQNLKILPTNDQVKELQTILRDKTTTRSDFKFYADRLIRLVIEESLNQLPFSKCVITTPTGAKYKGLKYQKGNCGVSIVRSGEAMEQGLRDCCRSIRIGKILVESDVDTHEARVVYAKFPDDIAERKILLMYPIMSTGNTVIKAIAVLKEHNVPEENIILSNLFCTPFAAKTLVTAFPKMKILTSEIHSVAPNHFGQKYFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGN2</accession>
    <name>A0A232EGN2_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_009400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004734">
        <property type="protein sequence ID" value="OXU17498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="543379.A0A232EGN2"/>
    <dbReference type="OrthoDB" id="8194903at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="469" mass="53854" checksum="D2EFF9CE47407E77" modified="2017-10-25" version="1">MIHEFPYFLWRQCMVLVGLWVAKKEPDMTVFLQPXCVKTDKVYISKVHFFIEIDPVQQLQRLFEDPIVINAVEERFYRNKIYKEYSKNPNLLGNPYNFSYTFNTDGCKSSDSSKVTICPIYMMIHEFPYFLRRECMVLVGLWVAKKEPDMTVFLQPFVDKANDLSTRGFKWKYNSEDVVSCLFPLGYCVDSPCRASMLNMKRFNGFYGCTYCEHPTESVDGVRKYPMLNDLPVLRTDNSINQKMIMAANENGKSDVTGVLGPSPLMYLKHFDLAKGMCMVLVGLWVAKKEPDMTVFLQPFVDKANDLSTRGFQWKYNSEDVVSCLFPLGCCVNSPCRASMLNMKRFNGFYGCAYCEHPTESVDGVRKYPMFNDPPVLRTDNSIKQKLIIAANENGKSDVTGVLGPSPLMYLKHFDLAKGSFFIEIDPVQQLQIVVEDPIVINALEDIFDGKIYKEYSKNPNLLGNPYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EGS0</accession>
    <name>A0A232EGS0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_005580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004695">
        <property type="protein sequence ID" value="OXU17541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EGS0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU17541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="94" mass="10064" checksum="B6B2AE15417E6C0B" modified="2017-10-25" version="1">MSLPQQPSLSTAGQTSQKKVSTVSTKKSNASELTGHGTVSLTGNQQEHVSPVNSAITPCSTGLRTSQARLFLRHRAYRQMGPQGIQARSNKDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EHE4</accession>
    <name>A0A232EHE4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_013342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004516">
        <property type="protein sequence ID" value="OXU17789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EHE4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU17789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="92" mass="10722" checksum="F3B303248A5C2650" modified="2017-10-25" version="1">MFSSLKGHCRNSSTTLMKHNFYKIAPRVQWGNPITCCDGDEAFVSYWRPMSLLYIVYWPIPDVQTSPQDFEKFNCQYLASKLTYSKRPGAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EIQ0</accession>
    <name>A0A232EIQ0_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_010199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01004218">
        <property type="protein sequence ID" value="OXU18188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EIQ0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="46" mass="5494" checksum="72FB76101B2E469A" modified="2017-10-25" version="1">MIISDYINKWRSSTTKASLRSRQSFGARDTIYFYIGVRIFHYTTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EJQ9</accession>
    <name>A0A232EJQ9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_015875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003952">
        <property type="protein sequence ID" value="OXU18599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EJQ9"/>
    <dbReference type="STRING" id="543379.A0A232EJQ9"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU18599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="184" mass="21614" checksum="2EB26AC162B726ED" modified="2017-10-25" version="1">MALTLRSQLIKENKLKQIKIIDYFLELREDNIAYDVNKTVEESQILRKYVLPSVEEIRRVALHIQGVRNESLAALKESYSDNDYRLLSESDIERITLDNLNTKYNITEESDPDLFKKLTTTSQETVSKYVRYSMRGKKGRLALRDSYLKIINKCTNLNYMYFITIKLNIVSIINTNLQHKEHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EK29</accession>
    <name>A0A232EK29_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_011277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003914">
        <property type="protein sequence ID" value="OXU18661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EK29"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24664">
        <property type="entry name" value="Monjiviricetes_fusion"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU18661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="516" mass="59438" checksum="D7CB588F768A2D75" modified="2017-10-25" version="1">MNEEAFVTEYVKLLKGDKSMQVLQYNCALWRNKTDIVWQRISKLMRILSGSMGRPRYQRRNLDLSSSSSWVQKGIDKLTINKKGDDVYCEAINTGRENILRAFMSHGVNPVTKKCLYNHAINKKANQLIPLLKTKGIRPTDLVAALQLAIREGSLEGIRELYTNKPMGRPLGFLHEAVKESKLWVFSLKEPAELEIVRGHDRDHLTVNAMGTLKLQLGCKAIESKKCPLIYMFPRLIALRNENVTYERMNYVQSVWKLESETIILQELKTEQERKKAKLLMISIGAATAIGVMFGLVITILCMKNIVKKEPELNITYQYIQLLQVNEFAKTHLMQCSIKVSRTITYYGMHSHSTRKCEKRNAIRSTFKQYMGTDGLKFGTASVALIGIIIIACLIKILIDTVLHSDAIYSVYRFSIHLIGSIWNSETANHRNLNLTLNYLKRKFRNRRSTVLSTITSKGNRMTKISINRIIEQYKKNFNDMSYEEILKKRVDITCAKLNEQETAKKFNKRLQTLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232ELD9</accession>
    <name>A0A232ELD9_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_002758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003573">
        <property type="protein sequence ID" value="OXU19170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232ELD9"/>
    <dbReference type="OrthoDB" id="6591467at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="130" mass="14454" checksum="394CE7B2C09AF883" modified="2017-10-25" version="1" fragment="single">VGATEPPTTAASNSTGVIYRAVRLLFASTVTRQDHARNGGIKFCCENVFILLCLSAQMMAYDPEDKSLKDILLPKGHFEAFYLKGDEDNVARPPHLHGSFHKHKNPALINAPNSAAYGFRFDGKRRFNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMF0</accession>
    <name>A0A232EMF0_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TSAR_006285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Alberta</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003397">
        <property type="protein sequence ID" value="OXU19482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMF0"/>
    <dbReference type="STRING" id="543379.A0A232EMF0"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OXU19482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="312" mass="35825" checksum="616D6AAABEEA6F95" modified="2017-10-25" version="1">MTSHQQQPKNLCLLQWNCLSLRQRKTELFDLSKDYDVILLCETWLNPLHNFSLQGFVIARNDEPVGRGGGTAICIRNSHPLPNGDLNCHNTTWSSSFSCNLGDHLFCTFVEHDLLVVNDGSPTYLNRRNPTNPLCLDLTLVSPHLYNICSWSVLEDKYLSDHYPIASFLGIPPPDSSFRSHRPNYRRIFPENWNDFRESLSNFSFDNLPADTSAAAKYEALTSSILLSVNNYIPPTRSSNKRPKSPKPPWWNEECSLAESARKRALKNFRRDPNLYSELLSNTHTLDLFCKLFTHSEFQIAIYKCLEKPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMJ4</accession>
    <name>A0A232EMJ4_9HYME</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TSAR_001803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Alberta</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003344">
        <property type="protein sequence ID" value="OXU19583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMJ4"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OXU19583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000215335"/>
        </source>
    </evidence>
    <sequence length="192" mass="21814" checksum="55AA4E3F2E6B17F9" modified="2017-10-25" version="1">MVEVVRHRLQQNYWRTFYDKHQQLYVLYEDLEDDQYFTTDYFSAIEDEYLNAKMQMTSRMVALIGVTPAAPVNNTRGASPAFSTTASSLPKLTLPSLQICQRTHEADTTNQCIRSLPSLGRSVVTWDDWLVQSIVFNLDPDTSEDSEVSLEGVSTFPIYSMLLSFLENRIKSSDTAHCSDTGNQPRPKATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-10-25" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A232EMQ4</accession>
    <name>A0A232EMQ4_9HYME</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TSAR_013349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trichomalopsis sarcophagae</name>
        <dbReference type="NCBI Taxonomy" id="543379"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Proctotrupomorpha</taxon>
            <taxon>Chalcidoidea</taxon>
            <taxon>Pteromalidae</taxon>
            <taxon>Pteromalinae</taxon>
            <taxon>Trichomalopsis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2017" name="Curr. Biol." volume="27" first="2007" last="2013">
            <title>The Evolution of Venom by Co-option of Single-Copy Genes.</title>
            <authorList>
                <person name="Martinson E.O."/>
                <person name="Mrinalini"/>
                <person name="Kelkar Y.D."/>
                <person name="Chang C.H."/>
                <person name="Werren J.H."/>
            </authorList>
            <dbReference type="PubMed" id="28648823"/>
            <dbReference type="DOI" id="10.1016/j.cub.2017.05.032"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Alberta</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NNAY01003342">
        <property type="protein sequence ID" value="OXU19592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A232EMQ4"/>
    <dbReference type="STRING" id="543379.A0A232EMQ4"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000215335">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13351">
        <property type="entry name" value="PH-GRAM1_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13354">
        <property type="entry name" value="PH-GRAM2_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000013">
        <property type="entry name" value="Putative TBC1 domain family member 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000049">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036014">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036017">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666:SF1">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <p
[file cut: first 33554432 bytes kept]
[document cut: first 30777454 of 33501869 characters kept]
